BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|38455388 frizzled-related protein [Homo sapiens] (325 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|38455388 frizzled-related protein [Homo sapiens] 674 0.0 gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] 316 2e-86 gi|27894385 frizzled 5 precursor [Homo sapiens] 140 1e-33 gi|13994190 frizzled 8 [Homo sapiens] 132 5e-31 gi|4503833 frizzled 7 [Homo sapiens] 130 2e-30 gi|4503827 frizzled 2 [Homo sapiens] 125 7e-29 gi|4503825 frizzled 1 [Homo sapiens] 124 1e-28 gi|4503835 frizzled 9 [Homo sapiens] 107 2e-23 gi|6005762 frizzled 10 [Homo sapiens] 105 7e-23 gi|22547161 frizzled 4 [Homo sapiens] 104 1e-22 gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] 96 4e-20 gi|8393378 frizzled 3 [Homo sapiens] 95 1e-19 gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] 91 2e-18 gi|48475052 secreted frizzled-related protein 2 precursor [Homo ... 91 2e-18 gi|29244926 corin [Homo sapiens] 90 2e-18 gi|34734079 frizzled 6 [Homo sapiens] 86 3e-17 gi|93204871 netrin 4 [Homo sapiens] 71 1e-12 gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] 63 3e-10 gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho... 62 5e-10 gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] 60 2e-09 gi|13899255 membrane frizzled-related protein [Homo sapiens] 60 3e-09 gi|5032099 smoothened [Homo sapiens] 41 0.002 gi|28212222 WFIKKN2 protein [Homo sapiens] 38 0.011 gi|148613884 netrin 1 [Homo sapiens] 32 0.77 gi|239047498 slingshot 1 isoform 3 [Homo sapiens] 31 1.3 gi|239047441 slingshot 1 isoform 2 [Homo sapiens] 31 1.3 gi|38348368 hypothetical protein LOC374872 [Homo sapiens] 31 1.7 gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 30 2.2 gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 30 2.2 gi|239753948 PREDICTED: hypothetical protein [Homo sapiens] 29 5.0 >gi|38455388 frizzled-related protein [Homo sapiens] Length = 325 Score = 674 bits (1738), Expect = 0.0 Identities = 325/325 (100%), Positives = 325/325 (100%) Query: 1 MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHS 60 MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHS Sbjct: 1 MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHS 60 Query: 61 TQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE 120 TQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE Sbjct: 61 TQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE 120 Query: 121 PILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKC 180 PILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKC Sbjct: 121 PILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKC 180 Query: 181 KPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTS 240 KPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTS Sbjct: 181 KPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTS 240 Query: 241 SGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSK 300 SGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSK Sbjct: 241 SGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSK 300 Query: 301 SDSSNSDSTQSQKSGRNSNPRQARN 325 SDSSNSDSTQSQKSGRNSNPRQARN Sbjct: 301 SDSSNSDSTQSQKSGRNSNPRQARN 325 >gi|170784838 secreted frizzled-related protein 4 [Homo sapiens] Length = 346 Score = 316 bits (809), Expect = 2e-86 Identities = 161/317 (50%), Positives = 212/317 (66%), Gaps = 25/317 (7%) Query: 16 LLALAALCLLR--VPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFE 73 L L ALCL G R A CE VRIP+C+ +PWN+T+MPNHLHHSTQ NAILAIEQ+E Sbjct: 3 LSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYE 62 Query: 74 GLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPEN 133 L+ +CS L FFLCAMYAPICT++F H+PIKPCKSVC+RAR CEP++ Y HSWPE+ Sbjct: 63 ELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPES 122 Query: 134 LACEELPVYDRGVCISPEAIVTADGADFPMDSS---------------NGNCRGASSERC 178 LAC+ELPVYDRGVCISPEAIVT D P D + +C+ S +RC Sbjct: 123 LACDELPVYDRGVCISPEAIVT----DLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRC 178 Query: 179 KCKPIRATQKTYFRNNYNYVIRAKVKEI-KTKCHDVTAVVEVKEILKSSLVNIPRDTVNL 237 KCK ++ T TY NY+YVI AK+K + ++ C++VT VV+VKEI KSS IPR V L Sbjct: 179 KCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSS-SPIPRTQVPL 237 Query: 238 YTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLG 297 T+S C CP + +++ +IM Y E RSR++L+E + EKW+D+L K+ +W+ +L+ Sbjct: 238 ITNSSCQCPHILPHQDVLIMCY--EWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQR 295 Query: 298 LSKSDSSNSDSTQSQKS 314 + D + S+ + Sbjct: 296 RTVQDKKKTAGRTSRSN 312 >gi|27894385 frizzled 5 precursor [Homo sapiens] Length = 585 Score = 140 bits (354), Expect = 1e-33 Identities = 73/191 (38%), Positives = 106/191 (55%), Gaps = 22/191 (11%) Query: 6 PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANA 65 P +LLL A L+ AA ++A C+ + +P+C+ + +N+T MPN +H TQ A Sbjct: 10 PSLLLLLLAQLVGRAAAA------SKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEA 63 Query: 66 ILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIK 125 L + QF L+ CSPDL FFLC+MY PIC D+ H+P+ PC+SVCERA+ GC P++ + Sbjct: 64 GLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDY-HKPLPPCRSVCERAKAGCSPLMRQ 122 Query: 126 YRHSWPENLACEELPVYDRG---VCI--SPEAIVTADGADFP----------MDSSNGNC 170 Y +WPE ++C+ LPV R +C+ + TA FP +S G C Sbjct: 123 YGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGEC 182 Query: 171 RGASSERCKCK 181 CKC+ Sbjct: 183 PAGGPFVCKCR 193 >gi|13994190 frizzled 8 [Homo sapiens] Length = 694 Score = 132 bits (331), Expect = 5e-31 Identities = 66/138 (47%), Positives = 88/138 (63%), Gaps = 7/138 (5%) Query: 8 GMLLLRAGLLALAALCLLRVPGARAA-----ACEPVRIPLCKSLPWNMTKMPNHLHHSTQ 62 G LL LLA AL L R GA AA AC+ + +PLCK + +N T MPN +H TQ Sbjct: 4 GYLLEVTSLLAALAL-LQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQ 62 Query: 63 ANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPI 122 A L + QF L+ CSPDL FFLC+MY PIC D++ +P+ PC+SVCERA+ GC P+ Sbjct: 63 DEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYK-KPLPPCRSVCERAKAGCAPL 121 Query: 123 LIKYRHSWPENLACEELP 140 + +Y +WP+ + C+ LP Sbjct: 122 MRQYGFAWPDRMRCDRLP 139 >gi|4503833 frizzled 7 [Homo sapiens] Length = 574 Score = 130 bits (327), Expect = 2e-30 Identities = 60/129 (46%), Positives = 84/129 (65%), Gaps = 6/129 (4%) Query: 35 CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94 C+P+ IPLC + +N T +PN L H+ Q +A L + QF L+ CSP+L FFLC+MYAP Sbjct: 49 CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108 Query: 95 ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-VCISPEAI 153 +CT+ + I PC+S+CERARQGCE ++ K+ WPE L CE PV+ G +C+ Sbjct: 109 VCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQN-- 164 Query: 154 VTADGADFP 162 T+DG+ P Sbjct: 165 -TSDGSGGP 172 >gi|4503827 frizzled 2 [Homo sapiens] Length = 565 Score = 125 bits (313), Expect = 7e-29 Identities = 54/106 (50%), Positives = 72/106 (67%), Gaps = 2/106 (1%) Query: 35 CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94 C+P+ IPLC + +N T MPN L H+ Q +A L + QF L+ CSP+L FFLC+MYAP Sbjct: 39 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98 Query: 95 ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140 +CT+ + I PC+S+CERARQGCE ++ K+ WPE L CE P Sbjct: 99 VCTV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFP 142 >gi|4503825 frizzled 1 [Homo sapiens] Length = 647 Score = 124 bits (310), Expect = 1e-28 Identities = 54/115 (46%), Positives = 78/115 (67%), Gaps = 3/115 (2%) Query: 35 CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94 C+P+ IPLC + +N T MPN L H+ Q +A L + QF L+ CS +L FFLC+MYAP Sbjct: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175 Query: 95 ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-VCI 148 +CT+ + + PC+S+CERARQGCE ++ K+ WP+ L CE+ PV+ G +C+ Sbjct: 176 VCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCV 228 >gi|4503835 frizzled 9 [Homo sapiens] Length = 591 Score = 107 bits (266), Expect = 2e-23 Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 3/152 (1%) Query: 11 LLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIE 70 LL AG AL G AA C+ V IP+C+ + +N+T+MPN L H++Q A + Sbjct: 15 LLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELA 74 Query: 71 QFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSW 130 +F L+ C L FFLC++YAP+CT D PI C+ +CE+AR C PI+ ++ W Sbjct: 75 EFAPLVQYGCHSHLRFFLCSLYAPMCT-DQVSTPIPACRPMCEQARLRCAPIMEQFNFGW 133 Query: 131 PENLACEELPVYD--RGVCISPEAIVTADGAD 160 P++L C LP + +C+ TA A+ Sbjct: 134 PDSLDCARLPTRNDPHALCMEAPENATAGPAE 165 >gi|6005762 frizzled 10 [Homo sapiens] Length = 581 Score = 105 bits (261), Expect = 7e-23 Identities = 44/106 (41%), Positives = 68/106 (64%), Gaps = 1/106 (0%) Query: 35 CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94 C+P+ IP+CK + +NMT+MPN + H Q A + + +F L+ C L FFLC++YAP Sbjct: 34 CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93 Query: 95 ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140 +CT + PI C+ +CE+AR C PI+ ++ WP++L C +LP Sbjct: 94 MCT-EQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLP 138 >gi|22547161 frizzled 4 [Homo sapiens] Length = 537 Score = 104 bits (259), Expect = 1e-22 Identities = 56/142 (39%), Positives = 83/142 (58%), Gaps = 5/142 (3%) Query: 2 VCGSPGGMLLLRAGLLALAALCLLRVPG---ARAAACEPVRIPLCKSLPWNMTKMPNHLH 58 V G+PGG+ L GLL L L G C+P+RI +C++L +N+TKMPN + Sbjct: 10 VPGAPGGVGL-SLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVG 68 Query: 59 HSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQG 118 H Q +A L + F L+ CS L FFLC++Y P+CT + + PI PC +C ++ Sbjct: 69 HELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT-EKINIPIGPCGGMCLSVKRR 127 Query: 119 CEPILIKYRHSWPENLACEELP 140 CEP+L ++ +WPE+L C + P Sbjct: 128 CEPVLKEFGFAWPESLNCSKFP 149 >gi|188528609 secreted frizzled-related protein 5 [Homo sapiens] Length = 317 Score = 95.9 bits (237), Expect = 4e-20 Identities = 70/265 (26%), Positives = 124/265 (46%), Gaps = 43/265 (16%) Query: 37 PVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPIC 96 P +PLC ++ + ++PN L H + A + LL C D FLC+++AP+C Sbjct: 57 PADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC 116 Query: 97 TIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPE----- 151 PI PC+S+CE R GC P++ Y WPE L C + P+ D +CI+ + Sbjct: 117 L----DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPL-DNDLCIAVQFGHLP 171 Query: 152 ---AIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKT 208 VT A M+ S G + C + ++V++ ++KEIK Sbjct: 172 ATAPPVTKICAQCEMEHS---ADGLMEQMC---------------SSDFVVKMRIKEIKI 213 Query: 209 KCHD--VTAVVEVKEILKSSLV---NIPRDTVNLYTSSGCLCPPL-NVNEEYIIMGYEDE 262 + D + + K++LK + + R +++ +GC CP L ++ +++MG + + Sbjct: 214 ENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVD 273 Query: 263 ERSRLLLVEGSIAEKWKDRLGKKVK 287 + L+ V +W D+ K++K Sbjct: 274 GQLLLMAV-----YRW-DKKNKEMK 292 >gi|8393378 frizzled 3 [Homo sapiens] Length = 666 Score = 94.7 bits (234), Expect = 1e-19 Identities = 44/117 (37%), Positives = 68/117 (58%), Gaps = 2/117 (1%) Query: 27 VPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLF 86 + G +CEP+ + +C+ LP+N T MPN L+H Q A LA+E F ++ CS D Sbjct: 20 IGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRP 79 Query: 87 FLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYD 143 FLCA+YAPIC +++ + PC+ +C+RA C ++ + WPE++ C P D Sbjct: 80 FLCALYAPIC-MEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCD 134 >gi|56117838 secreted frizzled-related protein 1 [Homo sapiens] Length = 314 Score = 90.5 bits (223), Expect = 2e-18 Identities = 68/263 (25%), Positives = 120/263 (45%), Gaps = 25/263 (9%) Query: 37 PVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPIC 96 P + LC ++ + +PN L H T A + LL +C FLC+++AP+C Sbjct: 62 PADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC 121 Query: 97 TIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTA 156 PI PC+ +CE R CEP++ + WPE L C++ P D VCI A+ Sbjct: 122 L----DRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGD--VCI---AMTPP 172 Query: 157 DGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAV 216 + + C +E +++ + +R K+KE+K + D V Sbjct: 173 NATEASKPQGTTVCPPCDNE------LKSEAIIEHLCASEFALRMKIKEVKKENGDKKIV 226 Query: 217 VEVKEILKSSLV---NIPRDTVNLYTSSGCLCPPL-NVNEEYIIMGYEDEERSRLLLVEG 272 + K+ LK + ++ + + L + C C L N++ ++IMG + +S+ LL Sbjct: 227 PKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMG--RKVKSQYLL--- 281 Query: 273 SIAEKWKDRLGKKVKRWDMKLRH 295 + KW D+ K+ K + K+++ Sbjct: 282 TAIHKW-DKKNKEFKNFMKKMKN 303 >gi|48475052 secreted frizzled-related protein 2 precursor [Homo sapiens] Length = 295 Score = 90.5 bits (223), Expect = 2e-18 Identities = 73/269 (27%), Positives = 124/269 (46%), Gaps = 28/269 (10%) Query: 6 PGGMLLL----RAGLLALAALCLLRVP--GARAAACEPV--RIPLCKSLPWNMTKMPNHL 57 PG +LLL L + L L P + + C+P+ + LC + + ++PN L Sbjct: 5 PGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLL 64 Query: 58 HHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQ 117 H T + + L+ C PD FLC+++AP+C +D E I+PC S+C + + Sbjct: 65 GHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVC-LDDLDETIQPCHSLCVQVKD 123 Query: 118 GCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSER 177 C P++ + WP+ L C+ P D +CI + ++D + + C E Sbjct: 124 RCAPVMSAFGFPWPDMLECDRFP-QDNDLCI---PLASSDHLLPATEEAPKVC-----EA 174 Query: 178 CKCK--PIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKE--ILKSSLV---NI 230 CK K +T +N ++ ++ KVKEI D ++E K I K + V ++ Sbjct: 175 CKNKNDDDNDIMETLCKN--DFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDL 232 Query: 231 PRDTVNLYTSSGCLCPPLN-VNEEYIIMG 258 + + L S C C +N +N Y++MG Sbjct: 233 KKSVLWLKDSLQCTCEEMNDINAPYLVMG 261 >gi|29244926 corin [Homo sapiens] Length = 1042 Score = 90.1 bits (222), Expect = 2e-18 Identities = 44/124 (35%), Positives = 68/124 (54%), Gaps = 5/124 (4%) Query: 35 CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQ--FEGLLGTHCSPDLLFFLCAMY 92 CEP+ + LC +LP+N T PN+ H TQ A ++ E F L+ T+C L+FF C + Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514 Query: 93 APICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPV--YDRGVCISP 150 P C ++ E I PC+++CE +++ CE +L WPE+ C + P D C+ P Sbjct: 515 VPKCDVN-TGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMP 573 Query: 151 EAIV 154 + V Sbjct: 574 DEYV 577 Score = 55.5 bits (132), Expect = 6e-08 Identities = 35/125 (28%), Positives = 55/125 (44%), Gaps = 7/125 (5%) Query: 33 AACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMY 92 +AC + C+ LP++ T P L ++ F L C ++ F C + Sbjct: 137 SACMNITHSQCQMLPYHATLTPL-LSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLA 195 Query: 93 APICTIDFQHEP-IKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-----V 146 P C ID + PC+S CE A++GCE +L +SWP+ L C + + Sbjct: 196 FPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRI 255 Query: 147 CISPE 151 C SP+ Sbjct: 256 CFSPQ 260 >gi|34734079 frizzled 6 [Homo sapiens] Length = 706 Score = 86.3 bits (212), Expect = 3e-17 Identities = 45/134 (33%), Positives = 67/134 (50%), Gaps = 4/134 (2%) Query: 16 LLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGL 75 LL L LLR G CEP+ +P C + +NMT PN + H Q+ A + +E F L Sbjct: 7 LLTCIFLPLLR--GHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPL 64 Query: 76 LGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLA 135 CSP++ FLC + P C Q + PC+ +CE+ C+ ++ + WPE L Sbjct: 65 ANLECSPNIETFLCKAFVPTCI--EQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELE 122 Query: 136 CEELPVYDRGVCIS 149 C+ L D V ++ Sbjct: 123 CDRLQYCDETVPVT 136 >gi|93204871 netrin 4 [Homo sapiens] Length = 628 Score = 70.9 bits (172), Expect = 1e-12 Identities = 40/117 (34%), Positives = 61/117 (52%), Gaps = 5/117 (4%) Query: 175 SERCKCKP-IRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRD 233 S +C+CK K + Y+YV++ K+ K V V++K++LKS+ + I R Sbjct: 503 SGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRG 562 Query: 234 TVNLY----TSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKV 286 LY T GC CP LN EY++ G+ED +L++ S + WK LG+KV Sbjct: 563 KRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKV 619 >gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens] Length = 652 Score = 63.2 bits (152), Expect = 3e-10 Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 8/130 (6%) Query: 26 RVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHST-----QANAILAIEQFEGLLGTHC 80 R P A +A C +++ C +N T PN L H + ++ + + LL C Sbjct: 34 RPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQC 93 Query: 81 SPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140 +PDL CA+ AP C + +PC+ +CE R+ C+P +WP L C Sbjct: 94 NPDLRLLGCAVLAPRCEGGWVR---RPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYF 150 Query: 141 VYDRGVCISP 150 + C P Sbjct: 151 TREDEGCYDP 160 >gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo sapiens] Length = 1751 Score = 62.4 bits (150), Expect = 5e-10 Identities = 40/123 (32%), Positives = 53/123 (43%), Gaps = 7/123 (5%) Query: 28 PGARAAACEPV--RIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLL 85 P A A C P+ +P+C L + +PNHLHH + + GLL THC P L Sbjct: 327 PEAPAGRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLA 386 Query: 86 FFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG 145 +F C + P C P PC CE + C L R +AC LP + G Sbjct: 387 WFFCLLLVPPCGSVPPPAP-PPCCQFCEALQDACWSRLGGGRLP----VACASLPTQEDG 441 Query: 146 VCI 148 C+ Sbjct: 442 YCV 444 >gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens] Length = 641 Score = 60.5 bits (145), Expect = 2e-09 Identities = 41/150 (27%), Positives = 61/150 (40%), Gaps = 8/150 (5%) Query: 6 PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHST---- 61 P LLL L+ AA AA C +++ C +N T PN L H + Sbjct: 3 PPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVV 62 Query: 62 -QANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE 120 ++ + + LL C+PDL CA+ AP C + +PC+ +CE R+ C+ Sbjct: 63 EASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVR---RPCRHICEGLREVCQ 119 Query: 121 PILIKYRHSWPENLACEELPVYDRGVCISP 150 P +WP L C + C P Sbjct: 120 PAFDAIDMAWPYFLDCHRYFTREDEGCYDP 149 >gi|13899255 membrane frizzled-related protein [Homo sapiens] Length = 579 Score = 60.1 bits (144), Expect = 3e-09 Identities = 37/119 (31%), Positives = 51/119 (42%), Gaps = 6/119 (5%) Query: 34 ACEPVRIPLCKSLPWNMTKMPN-HLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMY 92 ACEPV++ +C L +N T PN + TQ + + ++ L C LC + Sbjct: 465 ACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLL 524 Query: 93 APICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP-VYDRGVCISP 150 P CT + PC+SVC+ A C+ L WP N C LP D C P Sbjct: 525 VPRCTP--LGSVLPPCRSVCQEAEHQCQSGLALLGTPWPFN--CNRLPEAADLEACAQP 579 >gi|5032099 smoothened [Homo sapiens] Length = 787 Score = 40.8 bits (94), Expect = 0.002 Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 8/109 (7%) Query: 31 RAAACEPVRIPLC--KSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGT-HCSPDLLFF 87 RAA CEP+R +C LP+ T +Q A + + GL C + Sbjct: 66 RAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPL 125 Query: 88 LCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLAC 136 LCA+Y P C D P +++C+ R C +++ WP+ L C Sbjct: 126 LCAVYMPKCEND---RVELPSRTLCQATRGPC--AIVERERGWPDFLRC 169 >gi|28212222 WFIKKN2 protein [Homo sapiens] Length = 576 Score = 38.1 bits (87), Expect = 0.011 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 10/95 (10%) Query: 175 SERCK-CKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNI--- 230 ++RC+ CKP + ++ R+++ VI +V E+ + A+V V E+LK + + Sbjct: 442 NQRCRACKPRQKLVTSFCRSDF--VILGRVSELTEEPDSGRALVTVDEVLKDEKMGLKFL 499 Query: 231 ---PRDTVNLYTSSGCLCPPLNVNE-EYIIMGYED 261 P + L+ C CP + V+E IIMG D Sbjct: 500 GQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVD 534 >gi|148613884 netrin 1 [Homo sapiens] Length = 604 Score = 32.0 bits (71), Expect = 0.77 Identities = 15/81 (18%), Positives = 42/81 (51%), Gaps = 5/81 (6%) Query: 217 VEVKEILKSSLVNIPRDTVNLYTSS---GCLCPPLNVNEEYIIMGYEDE--ERSRLLLVE 271 V + + K I R +L+ S C CP + ++Y+++G ++ ++S ++ + Sbjct: 515 VNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADK 574 Query: 272 GSIAEKWKDRLGKKVKRWDMK 292 S+ +W+D ++++++ + Sbjct: 575 SSLVIQWRDTWARRLRKFQQR 595 >gi|239047498 slingshot 1 isoform 3 [Homo sapiens] Length = 703 Score = 31.2 bits (69), Expect = 1.3 Identities = 14/47 (29%), Positives = 23/47 (48%), Gaps = 7/47 (14%) Query: 48 WNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94 W+ +P+H + T A+ + G GT L+FF C ++AP Sbjct: 651 WHTPSLPSHSNWPTSASVV-------GTTGTRHHTQLIFFYCLLWAP 690 >gi|239047441 slingshot 1 isoform 2 [Homo sapiens] Length = 692 Score = 31.2 bits (69), Expect = 1.3 Identities = 14/47 (29%), Positives = 23/47 (48%), Gaps = 7/47 (14%) Query: 48 WNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94 W+ +P+H + T A+ + G GT L+FF C ++AP Sbjct: 640 WHTPSLPSHSNWPTSASVV-------GTTGTRHHTQLIFFYCLLWAP 679 >gi|38348368 hypothetical protein LOC374872 [Homo sapiens] Length = 473 Score = 30.8 bits (68), Expect = 1.7 Identities = 34/126 (26%), Positives = 51/126 (40%), Gaps = 11/126 (8%) Query: 12 LRAGLLALAALCLLRVPGARAAACEPVRIPLCK-------SLPWNMTKMPNHLHHSTQAN 64 +RA LL A C LR PG+ + EP+ PL K SLP T P+ + Sbjct: 30 IRAHLLPSKA-CRLRTPGSLSTNPEPLPPPLPKKILTRTQSLPTRRTLHPSSIQVQPPRR 88 Query: 65 AIL---AIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEP 121 L ++++ + +G C P L F A ++ H P ++ R QG Sbjct: 89 PFLGSHSVDKSQAAVGPACLPAELTFGPADAPLGLSLRDLHSPEAVHTALAARQLQGLRT 148 Query: 122 ILIKYR 127 I + R Sbjct: 149 IYARLR 154 >gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] Length = 413 Score = 30.4 bits (67), Expect = 2.2 Identities = 35/128 (27%), Positives = 48/128 (37%), Gaps = 14/128 (10%) Query: 6 PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIP--LCKSLPWNMTKMPNHLHHSTQA 63 PG LL +L L L LL PG+ A A P + L L WN + Sbjct: 13 PGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHL 72 Query: 64 NAILAIEQFEGLLGTH------CSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQ 117 +A+ A G+L + C+P L Y QH+ I PC+ C + Sbjct: 73 DALAA----GGVLLDNYYTQPLCTPSRSQLLTGRYQ--IRTGLQHQIIWPCQPSCVPLDE 126 Query: 118 GCEPILIK 125 P L+K Sbjct: 127 KLLPQLLK 134 >gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] Length = 533 Score = 30.4 bits (67), Expect = 2.2 Identities = 35/128 (27%), Positives = 48/128 (37%), Gaps = 14/128 (10%) Query: 6 PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIP--LCKSLPWNMTKMPNHLHHSTQA 63 PG LL +L L L LL PG+ A A P + L L WN + Sbjct: 13 PGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHL 72 Query: 64 NAILAIEQFEGLLGTH------CSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQ 117 +A+ A G+L + C+P L Y QH+ I PC+ C + Sbjct: 73 DALAA----GGVLLDNYYTQPLCTPSRSQLLTGRYQ--IRTGLQHQIIWPCQPSCVPLDE 126 Query: 118 GCEPILIK 125 P L+K Sbjct: 127 KLLPQLLK 134 >gi|239753948 PREDICTED: hypothetical protein [Homo sapiens] Length = 131 Score = 29.3 bits (64), Expect = 5.0 Identities = 14/22 (63%), Positives = 16/22 (72%) Query: 16 LLALAALCLLRVPGARAAACEP 37 L A+ A+C RVPGARAAA P Sbjct: 70 LPAIRAVCGARVPGARAAAAPP 91 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.135 0.421 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,107,816 Number of Sequences: 37866 Number of extensions: 581374 Number of successful extensions: 1438 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 24 Number of HSP's successfully gapped in prelim test: 12 Number of HSP's that attempted gapping in prelim test: 1385 Number of HSP's gapped (non-prelim): 39 length of query: 325 length of database: 18,247,518 effective HSP length: 102 effective length of query: 223 effective length of database: 14,385,186 effective search space: 3207896478 effective search space used: 3207896478 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.