Guide to the Human Genome
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Search of human proteins with 38455388

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38455388 frizzled-related protein [Homo sapiens]
         (325 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38455388 frizzled-related protein [Homo sapiens]                   674   0.0  
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]      316   2e-86
gi|27894385 frizzled 5 precursor [Homo sapiens]                       140   1e-33
gi|13994190 frizzled 8 [Homo sapiens]                                 132   5e-31
gi|4503833 frizzled 7 [Homo sapiens]                                  130   2e-30
gi|4503827 frizzled 2 [Homo sapiens]                                  125   7e-29
gi|4503825 frizzled 1 [Homo sapiens]                                  124   1e-28
gi|4503835 frizzled 9 [Homo sapiens]                                  107   2e-23
gi|6005762 frizzled 10 [Homo sapiens]                                 105   7e-23
gi|22547161 frizzled 4 [Homo sapiens]                                 104   1e-22
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]        96   4e-20
gi|8393378 frizzled 3 [Homo sapiens]                                   95   1e-19
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]         91   2e-18
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...    91   2e-18
gi|29244926 corin [Homo sapiens]                                       90   2e-18
gi|34734079 frizzled 6 [Homo sapiens]                                  86   3e-17
gi|93204871 netrin 4 [Homo sapiens]                                    71   1e-12
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                63   3e-10
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    62   5e-10
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      60   2e-09
gi|13899255 membrane frizzled-related protein [Homo sapiens]           60   3e-09
gi|5032099 smoothened [Homo sapiens]                                   41   0.002
gi|28212222 WFIKKN2 protein [Homo sapiens]                             38   0.011
gi|148613884 netrin 1 [Homo sapiens]                                   32   0.77 
gi|239047498 slingshot 1 isoform 3 [Homo sapiens]                      31   1.3  
gi|239047441 slingshot 1 isoform 2 [Homo sapiens]                      31   1.3  
gi|38348368 hypothetical protein LOC374872 [Homo sapiens]              31   1.7  
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]         30   2.2  
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]         30   2.2  
gi|239753948 PREDICTED: hypothetical protein [Homo sapiens]            29   5.0  

>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score =  674 bits (1738), Expect = 0.0
 Identities = 325/325 (100%), Positives = 325/325 (100%)

Query: 1   MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHS 60
           MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHS
Sbjct: 1   MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHS 60

Query: 61  TQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE 120
           TQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE
Sbjct: 61  TQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE 120

Query: 121 PILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKC 180
           PILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKC
Sbjct: 121 PILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKC 180

Query: 181 KPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTS 240
           KPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTS
Sbjct: 181 KPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTS 240

Query: 241 SGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSK 300
           SGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSK
Sbjct: 241 SGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSK 300

Query: 301 SDSSNSDSTQSQKSGRNSNPRQARN 325
           SDSSNSDSTQSQKSGRNSNPRQARN
Sbjct: 301 SDSSNSDSTQSQKSGRNSNPRQARN 325


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score =  316 bits (809), Expect = 2e-86
 Identities = 161/317 (50%), Positives = 212/317 (66%), Gaps = 25/317 (7%)

Query: 16  LLALAALCLLR--VPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFE 73
           L  L ALCL      G R A CE VRIP+C+ +PWN+T+MPNHLHHSTQ NAILAIEQ+E
Sbjct: 3   LSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYE 62

Query: 74  GLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPEN 133
            L+  +CS  L FFLCAMYAPICT++F H+PIKPCKSVC+RAR  CEP++  Y HSWPE+
Sbjct: 63  ELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPES 122

Query: 134 LACEELPVYDRGVCISPEAIVTADGADFPMDSS---------------NGNCRGASSERC 178
           LAC+ELPVYDRGVCISPEAIVT    D P D                 + +C+  S +RC
Sbjct: 123 LACDELPVYDRGVCISPEAIVT----DLPEDVKWIDITPDMMVQERPLDVDCKRLSPDRC 178

Query: 179 KCKPIRATQKTYFRNNYNYVIRAKVKEI-KTKCHDVTAVVEVKEILKSSLVNIPRDTVNL 237
           KCK ++ T  TY   NY+YVI AK+K + ++ C++VT VV+VKEI KSS   IPR  V L
Sbjct: 179 KCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSS-SPIPRTQVPL 237

Query: 238 YTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLG 297
            T+S C CP +  +++ +IM Y  E RSR++L+E  + EKW+D+L K+  +W+ +L+   
Sbjct: 238 ITNSSCQCPHILPHQDVLIMCY--EWRSRMMLLENCLVEKWRDQLSKRSIQWEERLQEQR 295

Query: 298 LSKSDSSNSDSTQSQKS 314
            +  D   +    S+ +
Sbjct: 296 RTVQDKKKTAGRTSRSN 312


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  140 bits (354), Expect = 1e-33
 Identities = 73/191 (38%), Positives = 106/191 (55%), Gaps = 22/191 (11%)

Query: 6   PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANA 65
           P  +LLL A L+  AA        ++A  C+ + +P+C+ + +N+T MPN  +H TQ  A
Sbjct: 10  PSLLLLLLAQLVGRAAAA------SKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEA 63

Query: 66  ILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIK 125
            L + QF  L+   CSPDL FFLC+MY PIC  D+ H+P+ PC+SVCERA+ GC P++ +
Sbjct: 64  GLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDY-HKPLPPCRSVCERAKAGCSPLMRQ 122

Query: 126 YRHSWPENLACEELPVYDRG---VCI--SPEAIVTADGADFP----------MDSSNGNC 170
           Y  +WPE ++C+ LPV  R    +C+  +     TA    FP            +S G C
Sbjct: 123 YGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGEC 182

Query: 171 RGASSERCKCK 181
                  CKC+
Sbjct: 183 PAGGPFVCKCR 193


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  132 bits (331), Expect = 5e-31
 Identities = 66/138 (47%), Positives = 88/138 (63%), Gaps = 7/138 (5%)

Query: 8   GMLLLRAGLLALAALCLLRVPGARAA-----ACEPVRIPLCKSLPWNMTKMPNHLHHSTQ 62
           G LL    LLA  AL L R  GA AA     AC+ + +PLCK + +N T MPN  +H TQ
Sbjct: 4   GYLLEVTSLLAALAL-LQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQ 62

Query: 63  ANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPI 122
             A L + QF  L+   CSPDL FFLC+MY PIC  D++ +P+ PC+SVCERA+ GC P+
Sbjct: 63  DEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYK-KPLPPCRSVCERAKAGCAPL 121

Query: 123 LIKYRHSWPENLACEELP 140
           + +Y  +WP+ + C+ LP
Sbjct: 122 MRQYGFAWPDRMRCDRLP 139


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  130 bits (327), Expect = 2e-30
 Identities = 60/129 (46%), Positives = 84/129 (65%), Gaps = 6/129 (4%)

Query: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94
           C+P+ IPLC  + +N T +PN L H+ Q +A L + QF  L+   CSP+L FFLC+MYAP
Sbjct: 49  CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 108

Query: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-VCISPEAI 153
           +CT+    + I PC+S+CERARQGCE ++ K+   WPE L CE  PV+  G +C+     
Sbjct: 109 VCTV--LDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQN-- 164

Query: 154 VTADGADFP 162
            T+DG+  P
Sbjct: 165 -TSDGSGGP 172


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  125 bits (313), Expect = 7e-29
 Identities = 54/106 (50%), Positives = 72/106 (67%), Gaps = 2/106 (1%)

Query: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94
           C+P+ IPLC  + +N T MPN L H+ Q +A L + QF  L+   CSP+L FFLC+MYAP
Sbjct: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98

Query: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140
           +CT+    + I PC+S+CERARQGCE ++ K+   WPE L CE  P
Sbjct: 99  VCTV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFP 142


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  124 bits (310), Expect = 1e-28
 Identities = 54/115 (46%), Positives = 78/115 (67%), Gaps = 3/115 (2%)

Query: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94
           C+P+ IPLC  + +N T MPN L H+ Q +A L + QF  L+   CS +L FFLC+MYAP
Sbjct: 116 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAELKFFLCSMYAP 175

Query: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-VCI 148
           +CT+    + + PC+S+CERARQGCE ++ K+   WP+ L CE+ PV+  G +C+
Sbjct: 176 VCTV--LEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGAGELCV 228


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  107 bits (266), Expect = 2e-23
 Identities = 57/152 (37%), Positives = 84/152 (55%), Gaps = 3/152 (1%)

Query: 11  LLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIE 70
           LL AG  AL         G  AA C+ V IP+C+ + +N+T+MPN L H++Q  A   + 
Sbjct: 15  LLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELA 74

Query: 71  QFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSW 130
           +F  L+   C   L FFLC++YAP+CT D    PI  C+ +CE+AR  C PI+ ++   W
Sbjct: 75  EFAPLVQYGCHSHLRFFLCSLYAPMCT-DQVSTPIPACRPMCEQARLRCAPIMEQFNFGW 133

Query: 131 PENLACEELPVYD--RGVCISPEAIVTADGAD 160
           P++L C  LP  +    +C+      TA  A+
Sbjct: 134 PDSLDCARLPTRNDPHALCMEAPENATAGPAE 165


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  105 bits (261), Expect = 7e-23
 Identities = 44/106 (41%), Positives = 68/106 (64%), Gaps = 1/106 (0%)

Query: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94
           C+P+ IP+CK + +NMT+MPN + H  Q  A + + +F  L+   C   L FFLC++YAP
Sbjct: 34  CQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAP 93

Query: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140
           +CT +    PI  C+ +CE+AR  C PI+ ++   WP++L C +LP
Sbjct: 94  MCT-EQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLP 138


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  104 bits (259), Expect = 1e-22
 Identities = 56/142 (39%), Positives = 83/142 (58%), Gaps = 5/142 (3%)

Query: 2   VCGSPGGMLLLRAGLLALAALCLLRVPG---ARAAACEPVRIPLCKSLPWNMTKMPNHLH 58
           V G+PGG+ L   GLL    L L    G        C+P+RI +C++L +N+TKMPN + 
Sbjct: 10  VPGAPGGVGL-SLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVG 68

Query: 59  HSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQG 118
           H  Q +A L +  F  L+   CS  L FFLC++Y P+CT +  + PI PC  +C   ++ 
Sbjct: 69  HELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCT-EKINIPIGPCGGMCLSVKRR 127

Query: 119 CEPILIKYRHSWPENLACEELP 140
           CEP+L ++  +WPE+L C + P
Sbjct: 128 CEPVLKEFGFAWPESLNCSKFP 149


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 70/265 (26%), Positives = 124/265 (46%), Gaps = 43/265 (16%)

Query: 37  PVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPIC 96
           P  +PLC ++ +   ++PN L H + A        +  LL   C  D   FLC+++AP+C
Sbjct: 57  PADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVC 116

Query: 97  TIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPE----- 151
                  PI PC+S+CE  R GC P++  Y   WPE L C + P+ D  +CI+ +     
Sbjct: 117 L----DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPL-DNDLCIAVQFGHLP 171

Query: 152 ---AIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKT 208
                VT   A   M+ S     G   + C               + ++V++ ++KEIK 
Sbjct: 172 ATAPPVTKICAQCEMEHS---ADGLMEQMC---------------SSDFVVKMRIKEIKI 213

Query: 209 KCHD--VTAVVEVKEILKSSLV---NIPRDTVNLYTSSGCLCPPL-NVNEEYIIMGYEDE 262
           +  D  +    + K++LK   +   +  R  +++   +GC CP L ++   +++MG + +
Sbjct: 214 ENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVD 273

Query: 263 ERSRLLLVEGSIAEKWKDRLGKKVK 287
            +  L+ V      +W D+  K++K
Sbjct: 274 GQLLLMAV-----YRW-DKKNKEMK 292


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 44/117 (37%), Positives = 68/117 (58%), Gaps = 2/117 (1%)

Query: 27  VPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLF 86
           + G    +CEP+ + +C+ LP+N T MPN L+H  Q  A LA+E F  ++   CS D   
Sbjct: 20  IGGHSLFSCEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRP 79

Query: 87  FLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYD 143
           FLCA+YAPIC +++    + PC+ +C+RA   C  ++  +   WPE++ C   P  D
Sbjct: 80  FLCALYAPIC-MEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCD 134


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 68/263 (25%), Positives = 120/263 (45%), Gaps = 25/263 (9%)

Query: 37  PVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPIC 96
           P  + LC ++ +    +PN L H T A        +  LL  +C      FLC+++AP+C
Sbjct: 62  PADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC 121

Query: 97  TIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTA 156
                  PI PC+ +CE  R  CEP++  +   WPE L C++ P  D  VCI   A+   
Sbjct: 122 L----DRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGD--VCI---AMTPP 172

Query: 157 DGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAV 216
           +  +         C    +E      +++           + +R K+KE+K +  D   V
Sbjct: 173 NATEASKPQGTTVCPPCDNE------LKSEAIIEHLCASEFALRMKIKEVKKENGDKKIV 226

Query: 217 VEVKEILKSSLV---NIPRDTVNLYTSSGCLCPPL-NVNEEYIIMGYEDEERSRLLLVEG 272
            + K+ LK   +   ++ +  + L   + C C  L N++  ++IMG   + +S+ LL   
Sbjct: 227 PKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMG--RKVKSQYLL--- 281

Query: 273 SIAEKWKDRLGKKVKRWDMKLRH 295
           +   KW D+  K+ K +  K+++
Sbjct: 282 TAIHKW-DKKNKEFKNFMKKMKN 303


>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 73/269 (27%), Positives = 124/269 (46%), Gaps = 28/269 (10%)

Query: 6   PGGMLLL----RAGLLALAALCLLRVP--GARAAACEPV--RIPLCKSLPWNMTKMPNHL 57
           PG +LLL       L +   L L   P    + + C+P+   + LC  + +   ++PN L
Sbjct: 5   PGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLL 64

Query: 58  HHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQ 117
            H T    +     +  L+   C PD   FLC+++AP+C +D   E I+PC S+C + + 
Sbjct: 65  GHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVC-LDDLDETIQPCHSLCVQVKD 123

Query: 118 GCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSER 177
            C P++  +   WP+ L C+  P  D  +CI    + ++D      + +   C     E 
Sbjct: 124 RCAPVMSAFGFPWPDMLECDRFP-QDNDLCI---PLASSDHLLPATEEAPKVC-----EA 174

Query: 178 CKCK--PIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKE--ILKSSLV---NI 230
           CK K        +T  +N  ++ ++ KVKEI     D   ++E K   I K + V   ++
Sbjct: 175 CKNKNDDDNDIMETLCKN--DFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDL 232

Query: 231 PRDTVNLYTSSGCLCPPLN-VNEEYIIMG 258
            +  + L  S  C C  +N +N  Y++MG
Sbjct: 233 KKSVLWLKDSLQCTCEEMNDINAPYLVMG 261


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 44/124 (35%), Positives = 68/124 (54%), Gaps = 5/124 (4%)

Query: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQ--FEGLLGTHCSPDLLFFLCAMY 92
           CEP+ + LC +LP+N T  PN+  H TQ  A ++ E   F  L+ T+C   L+FF C + 
Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514

Query: 93  APICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPV--YDRGVCISP 150
            P C ++   E I PC+++CE +++ CE +L      WPE+  C + P    D   C+ P
Sbjct: 515 VPKCDVN-TGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMP 573

Query: 151 EAIV 154
           +  V
Sbjct: 574 DEYV 577



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 35/125 (28%), Positives = 55/125 (44%), Gaps = 7/125 (5%)

Query: 33  AACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMY 92
           +AC  +    C+ LP++ T  P  L           ++ F  L    C   ++ F C + 
Sbjct: 137 SACMNITHSQCQMLPYHATLTPL-LSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLA 195

Query: 93  APICTIDFQHEP-IKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG-----V 146
            P C ID      + PC+S CE A++GCE +L    +SWP+ L C +            +
Sbjct: 196 FPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRI 255

Query: 147 CISPE 151
           C SP+
Sbjct: 256 CFSPQ 260


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 45/134 (33%), Positives = 67/134 (50%), Gaps = 4/134 (2%)

Query: 16  LLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGL 75
           LL    L LLR  G     CEP+ +P C  + +NMT  PN + H  Q+ A + +E F  L
Sbjct: 7   LLTCIFLPLLR--GHSLFTCEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPL 64

Query: 76  LGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLA 135
               CSP++  FLC  + P C    Q   + PC+ +CE+    C+ ++  +   WPE L 
Sbjct: 65  ANLECSPNIETFLCKAFVPTCI--EQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELE 122

Query: 136 CEELPVYDRGVCIS 149
           C+ L   D  V ++
Sbjct: 123 CDRLQYCDETVPVT 136


>gi|93204871 netrin 4 [Homo sapiens]
          Length = 628

 Score = 70.9 bits (172), Expect = 1e-12
 Identities = 40/117 (34%), Positives = 61/117 (52%), Gaps = 5/117 (4%)

Query: 175 SERCKCKP-IRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRD 233
           S +C+CK       K +    Y+YV++ K+     K   V   V++K++LKS+ + I R 
Sbjct: 503 SGKCECKEQTLGNAKAFCGMKYSYVLKIKILSAHDKGTHVEVNVKIKKVLKSTKLKIFRG 562

Query: 234 TVNLY----TSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKV 286
              LY    T  GC CP LN   EY++ G+ED    +L++   S  + WK  LG+KV
Sbjct: 563 KRTLYPESWTDRGCTCPILNPGLEYLVAGHEDIRTGKLIVNMKSFVQHWKPSLGRKV 619


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 36/130 (27%), Positives = 56/130 (43%), Gaps = 8/130 (6%)

Query: 26  RVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHST-----QANAILAIEQFEGLLGTHC 80
           R P A +A C  +++  C    +N T  PN L H +      ++  + +     LL   C
Sbjct: 34  RPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQC 93

Query: 81  SPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140
           +PDL    CA+ AP C   +     +PC+ +CE  R+ C+P       +WP  L C    
Sbjct: 94  NPDLRLLGCAVLAPRCEGGWVR---RPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYF 150

Query: 141 VYDRGVCISP 150
             +   C  P
Sbjct: 151 TREDEGCYDP 160


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 40/123 (32%), Positives = 53/123 (43%), Gaps = 7/123 (5%)

Query: 28  PGARAAACEPV--RIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLL 85
           P A A  C P+   +P+C  L  +   +PNHLHH +          + GLL THC P L 
Sbjct: 327 PEAPAGRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLA 386

Query: 86  FFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRG 145
           +F C +  P C       P  PC   CE  +  C   L   R      +AC  LP  + G
Sbjct: 387 WFFCLLLVPPCGSVPPPAP-PPCCQFCEALQDACWSRLGGGRLP----VACASLPTQEDG 441

Query: 146 VCI 148
            C+
Sbjct: 442 YCV 444


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 41/150 (27%), Positives = 61/150 (40%), Gaps = 8/150 (5%)

Query: 6   PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHST---- 61
           P   LLL   L+  AA          AA C  +++  C    +N T  PN L H +    
Sbjct: 3   PPPPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVV 62

Query: 62  -QANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCE 120
             ++  + +     LL   C+PDL    CA+ AP C   +     +PC+ +CE  R+ C+
Sbjct: 63  EASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVR---RPCRHICEGLREVCQ 119

Query: 121 PILIKYRHSWPENLACEELPVYDRGVCISP 150
           P       +WP  L C      +   C  P
Sbjct: 120 PAFDAIDMAWPYFLDCHRYFTREDEGCYDP 149


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 37/119 (31%), Positives = 51/119 (42%), Gaps = 6/119 (5%)

Query: 34  ACEPVRIPLCKSLPWNMTKMPN-HLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMY 92
           ACEPV++ +C  L +N T  PN  +   TQ   +  +  ++ L    C       LC + 
Sbjct: 465 ACEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLL 524

Query: 93  APICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP-VYDRGVCISP 150
            P CT       + PC+SVC+ A   C+  L      WP N  C  LP   D   C  P
Sbjct: 525 VPRCTP--LGSVLPPCRSVCQEAEHQCQSGLALLGTPWPFN--CNRLPEAADLEACAQP 579


>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 31/109 (28%), Positives = 47/109 (43%), Gaps = 8/109 (7%)

Query: 31  RAAACEPVRIPLC--KSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGT-HCSPDLLFF 87
           RAA CEP+R  +C    LP+  T         +Q  A   +  + GL     C   +   
Sbjct: 66  RAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPL 125

Query: 88  LCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLAC 136
           LCA+Y P C  D       P +++C+  R  C   +++    WP+ L C
Sbjct: 126 LCAVYMPKCEND---RVELPSRTLCQATRGPC--AIVERERGWPDFLRC 169


>gi|28212222 WFIKKN2 protein [Homo sapiens]
          Length = 576

 Score = 38.1 bits (87), Expect = 0.011
 Identities = 28/95 (29%), Positives = 48/95 (50%), Gaps = 10/95 (10%)

Query: 175 SERCK-CKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNI--- 230
           ++RC+ CKP +    ++ R+++  VI  +V E+  +     A+V V E+LK   + +   
Sbjct: 442 NQRCRACKPRQKLVTSFCRSDF--VILGRVSELTEEPDSGRALVTVDEVLKDEKMGLKFL 499

Query: 231 ---PRDTVNLYTSSGCLCPPLNVNE-EYIIMGYED 261
              P +   L+    C CP + V+E   IIMG  D
Sbjct: 500 GQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGEVD 534


>gi|148613884 netrin 1 [Homo sapiens]
          Length = 604

 Score = 32.0 bits (71), Expect = 0.77
 Identities = 15/81 (18%), Positives = 42/81 (51%), Gaps = 5/81 (6%)

Query: 217 VEVKEILKSSLVNIPRDTVNLYTSS---GCLCPPLNVNEEYIIMGYEDE--ERSRLLLVE 271
           V +  + K     I R   +L+  S    C CP +   ++Y+++G  ++  ++S ++  +
Sbjct: 515 VNIISVYKQGTSRIRRGDQSLWIRSRDIACKCPKIKPLKKYLLLGNAEDSPDQSGIVADK 574

Query: 272 GSIAEKWKDRLGKKVKRWDMK 292
            S+  +W+D   ++++++  +
Sbjct: 575 SSLVIQWRDTWARRLRKFQQR 595


>gi|239047498 slingshot 1 isoform 3 [Homo sapiens]
          Length = 703

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 14/47 (29%), Positives = 23/47 (48%), Gaps = 7/47 (14%)

Query: 48  WNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94
           W+   +P+H +  T A+ +       G  GT     L+FF C ++AP
Sbjct: 651 WHTPSLPSHSNWPTSASVV-------GTTGTRHHTQLIFFYCLLWAP 690


>gi|239047441 slingshot 1 isoform 2 [Homo sapiens]
          Length = 692

 Score = 31.2 bits (69), Expect = 1.3
 Identities = 14/47 (29%), Positives = 23/47 (48%), Gaps = 7/47 (14%)

Query: 48  WNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94
           W+   +P+H +  T A+ +       G  GT     L+FF C ++AP
Sbjct: 640 WHTPSLPSHSNWPTSASVV-------GTTGTRHHTQLIFFYCLLWAP 679


>gi|38348368 hypothetical protein LOC374872 [Homo sapiens]
          Length = 473

 Score = 30.8 bits (68), Expect = 1.7
 Identities = 34/126 (26%), Positives = 51/126 (40%), Gaps = 11/126 (8%)

Query: 12  LRAGLLALAALCLLRVPGARAAACEPVRIPLCK-------SLPWNMTKMPNHLHHSTQAN 64
           +RA LL   A C LR PG+ +   EP+  PL K       SLP   T  P+ +       
Sbjct: 30  IRAHLLPSKA-CRLRTPGSLSTNPEPLPPPLPKKILTRTQSLPTRRTLHPSSIQVQPPRR 88

Query: 65  AIL---AIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEP 121
             L   ++++ +  +G  C P  L F  A      ++   H P     ++  R  QG   
Sbjct: 89  PFLGSHSVDKSQAAVGPACLPAELTFGPADAPLGLSLRDLHSPEAVHTALAARQLQGLRT 148

Query: 122 ILIKYR 127
           I  + R
Sbjct: 149 IYARLR 154


>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
          Length = 413

 Score = 30.4 bits (67), Expect = 2.2
 Identities = 35/128 (27%), Positives = 48/128 (37%), Gaps = 14/128 (10%)

Query: 6   PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIP--LCKSLPWNMTKMPNHLHHSTQA 63
           PG   LL   +L L  L LL  PG+ A A  P  +   L   L WN          +   
Sbjct: 13  PGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHL 72

Query: 64  NAILAIEQFEGLLGTH------CSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQ 117
           +A+ A     G+L  +      C+P     L   Y        QH+ I PC+  C    +
Sbjct: 73  DALAA----GGVLLDNYYTQPLCTPSRSQLLTGRYQ--IRTGLQHQIIWPCQPSCVPLDE 126

Query: 118 GCEPILIK 125
              P L+K
Sbjct: 127 KLLPQLLK 134


>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
          Length = 533

 Score = 30.4 bits (67), Expect = 2.2
 Identities = 35/128 (27%), Positives = 48/128 (37%), Gaps = 14/128 (10%)

Query: 6   PGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIP--LCKSLPWNMTKMPNHLHHSTQA 63
           PG   LL   +L L  L LL  PG+ A A  P  +   L   L WN          +   
Sbjct: 13  PGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHL 72

Query: 64  NAILAIEQFEGLLGTH------CSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQ 117
           +A+ A     G+L  +      C+P     L   Y        QH+ I PC+  C    +
Sbjct: 73  DALAA----GGVLLDNYYTQPLCTPSRSQLLTGRYQ--IRTGLQHQIIWPCQPSCVPLDE 126

Query: 118 GCEPILIK 125
              P L+K
Sbjct: 127 KLLPQLLK 134


>gi|239753948 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 131

 Score = 29.3 bits (64), Expect = 5.0
 Identities = 14/22 (63%), Positives = 16/22 (72%)

Query: 16 LLALAALCLLRVPGARAAACEP 37
          L A+ A+C  RVPGARAAA  P
Sbjct: 70 LPAIRAVCGARVPGARAAAAPP 91


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,107,816
Number of Sequences: 37866
Number of extensions: 581374
Number of successful extensions: 1438
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1385
Number of HSP's gapped (non-prelim): 39
length of query: 325
length of database: 18,247,518
effective HSP length: 102
effective length of query: 223
effective length of database: 14,385,186
effective search space: 3207896478
effective search space used: 3207896478
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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