Search of human proteins with 38327522

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
         (319 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]             635   0.0  
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]          258   6e-69
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]    233   1e-61
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]         173   2e-43
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  108   8e-24
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   100   2e-21
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           99   4e-21
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    99   4e-21
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        98   9e-21
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         98   9e-21
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         98   9e-21
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         98   9e-21
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         98   9e-21
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    97   2e-20
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...    96   3e-20
gi|55742857 ankyrin repeat domain 6 [Homo sapiens]                     96   6e-20
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...    89   4e-18
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         89   5e-18
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [...    88   1e-17
gi|34304381 inversin isoform a [Homo sapiens]                          87   3e-17
gi|34304379 inversin isoform b [Homo sapiens]                          87   3e-17
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    87   3e-17
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...    86   4e-17
gi|118150656 ankyrin repeat domain 7 [Homo sapiens]                    86   6e-17
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1...    85   7e-17
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        85   1e-16
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         85   1e-16
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         85   1e-16
gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens]              84   1e-16
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    84   1e-16

>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
          Length = 319

 Score =  635 bits (1639), Expect = 0.0
 Identities = 319/319 (100%), Positives = 319/319 (100%)

Query: 1   MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQW 60
           MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQW
Sbjct: 1   MMVLKVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQW 60

Query: 61  KSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVD 120
           KSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVD
Sbjct: 61  KSEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVD 120

Query: 121 VPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIE 180
           VPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIE
Sbjct: 121 VPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIE 180

Query: 181 FRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIA 240
           FRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIA
Sbjct: 181 FRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIA 240

Query: 241 CEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK 300
           CEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK
Sbjct: 241 CEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK 300

Query: 301 AIFDSLRENSYKTSRIATF 319
           AIFDSLRENSYKTSRIATF
Sbjct: 301 AIFDSLRENSYKTSRIATF 319


>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
          Length = 360

 Score =  258 bits (658), Expect = 6e-69
 Identities = 125/237 (52%), Positives = 175/237 (73%), Gaps = 3/237 (1%)

Query: 67  EAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKE---PEPEIITEPVDVPT 123
           +  ++K  L+ R ++ ++  ++ +I+L+K++K +K           PEPE IT PVD  T
Sbjct: 92  QERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEET 151

Query: 124 FLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD 183
           FLKAA+E K+ V+EKFL+D  + D CD+++RTALHRA LEGH+ I+EKL++ GA ++F+D
Sbjct: 152 FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211

Query: 184 MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
            L+ TA+HWA RGG+L+V+KLL + GA  + RDKLLST LHVAVRTG  E  EH ++   
Sbjct: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL 271

Query: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTK 300
           ++NA+DREGDT LHDAVRLNRYK+I+LL+++GAD+  KN AGKTP DLV  WQ  T+
Sbjct: 272 EINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTR 328


>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
          Length = 305

 Score =  233 bits (595), Expect = 1e-61
 Identities = 134/305 (43%), Positives = 188/305 (61%), Gaps = 36/305 (11%)

Query: 5   KVEELVTGKKNGNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEK 64
           +VE  V G  +G  + G + P D+R G  EA                           EK
Sbjct: 14  RVEGKVLGFGHGVPDPGAW-PSDWRRGPQEAVAR------------------------EK 48

Query: 65  QREAELKKKKLEQ----RSKLENLEDLEIIIQLKKRKKYRKTKVPVVK-----EPEPEII 115
            +  E KKKKLE+    R  L+NL DLE ++Q  +RKK  + +VP  K     +P+ +  
Sbjct: 49  LKLEEEKKKKLERFNSTRFNLDNLADLENLVQ--RRKKRLRHRVPPRKPEPLVKPQSQAQ 106

Query: 116 TEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEA 175
            EPV +  FLKAA EN+  +++K+L+D  +P+  D+  RTALH ACL+GH  +V KL+ A
Sbjct: 107 VEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVA 166

Query: 176 GAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECA 235
           GA ++ RD+L+ T + WA RGG+L +LK LLN+GA+++ARDK+ ST LHVAVRT H +C 
Sbjct: 167 GATVDARDLLDRTPVFWACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCL 226

Query: 236 EHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295
           EHLI C A LNA+D+EGDT LH+AVR   YK ++LL++YGA+L ++N A  TP+ L   W
Sbjct: 227 EHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDW 286

Query: 296 QNGTK 300
           Q G +
Sbjct: 287 QRGIR 291


>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
          Length = 327

 Score =  173 bits (438), Expect = 2e-43
 Identities = 90/199 (45%), Positives = 134/199 (67%), Gaps = 4/199 (2%)

Query: 67  EAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKE---PEPEIITEPVDVPT 123
           +  ++K  L+ R ++ ++  ++ +I+L+K++K +K           PEPE IT PVD  T
Sbjct: 92  QERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAASHEPPPEPEEITGPVDEET 151

Query: 124 FLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD 183
           FLKAA+E K+ V+EKFL+D  + D CD+++RTALHRA LEGH+ I+EKL++ GA ++F+D
Sbjct: 152 FLKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQD 211

Query: 184 MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
            L+ TA+HWA RGG+L+V+KLL + GA  + RDK   TALH AVR   Y+  + L+   A
Sbjct: 212 RLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKEGDTALHDAVRLNRYKIIKLLLLHGA 271

Query: 244 DLNAKDREGDTPLHDAVRL 262
           D+  K+  G TP  D V+L
Sbjct: 272 DMMTKNLAGKTPT-DLVQL 289


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  108 bits (269), Expect = 8e-24
 Identities = 65/176 (36%), Positives = 91/176 (51%), Gaps = 4/176 (2%)

Query: 120 DVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQI 179
           D P  ++A     +  V   LS K N +V D+ +RT LH A   G + I++ L+ +GA +
Sbjct: 8   DQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANV 67

Query: 180 EFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLI 239
             +D L  T +H A+   N  VL LLL   A ++ARDKL  T LHVA      +CAE L 
Sbjct: 68  NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127

Query: 240 ACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295
              + LN  DR G + LH AV     + + LL+  GA LN+ +   + P    LHW
Sbjct: 128 PLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQP----LHW 179



 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 54/160 (33%), Positives = 87/160 (54%), Gaps = 1/160 (0%)

Query: 133 LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHW 192
           L  V   L+   + +VCD+ +R  LH A   GHL +++ L+  GA +  +D      +H 
Sbjct: 153 LETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHT 212

Query: 193 ASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREG 252
           A+  G ++V+K LL  GA+I   +   +TALH+A   G    A  L+   A++N  + +G
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272

Query: 253 DTPLH-DAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            TPLH  AV  N    + LL+  GAD+N ++  GK+P+ +
Sbjct: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHM 312



 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 52/152 (34%), Positives = 81/152 (53%)

Query: 147 DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLL 206
           +V D   R+ALH A   GHL  V  L+  GA +   D  E   +HWA+  G+L+VLKLL+
Sbjct: 134 NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLV 193

Query: 207 NKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYK 266
            +GA +  +D+     LH A  +G  E  ++L+   A+++  +  G+T LH A  L +  
Sbjct: 194 ARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDA 253

Query: 267 MIRLLIMYGADLNIKNCAGKTPMDLVLHWQNG 298
           +   L+  GA++N  N  G TP+ +     NG
Sbjct: 254 VAIELVNAGANVNQPNDKGFTPLHVAAVSTNG 285



 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 52/177 (29%), Positives = 83/177 (46%)

Query: 126 KAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDML 185
           +AA      V+   L+   + +  D+  +T LH A         E L    + +   D  
Sbjct: 80  RAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRS 139

Query: 186 ESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADL 245
             +A+H A   G+L+ + LLLNKGA ++  DK     LH A   GH E  + L+A  ADL
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199

Query: 246 NAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAI 302
             KDR+G   LH A    + ++++ L+  GA+++  N  G T + +  +      AI
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAI 256



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 39/97 (40%), Positives = 54/97 (55%)

Query: 170 EKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRT 229
           E ++ AG  I   D L  T +H A+ GGN++ L LLL+ GA +  RDK   T LH A   
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466

Query: 230 GHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYK 266
           G Y+CA  L+   A +N  D +G +PLH A   + Y+
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYR 503



 Score = 73.6 bits (179), Expect = 2e-13
 Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 18/181 (9%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA+  +    +  + + +  D  D++  T LH A   GH  ++  LM  GA    R + +
Sbjct: 313 AAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHD 372

Query: 187 STAIHWASRGGNLDVLKLLLNKGA------------------KISARDKLLSTALHVAVR 228
              +H A   G  D  + LL+ G                    I+  D L  T LH A  
Sbjct: 373 MFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAAS 432

Query: 229 TGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTP 288
            G+ EC   L++  ADL  +D+ G TPLH A     Y+    L+  GA +N  +C G +P
Sbjct: 433 GGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSP 492

Query: 289 M 289
           +
Sbjct: 493 L 493



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 50/168 (29%), Positives = 84/168 (50%), Gaps = 1/168 (0%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA   ++ VV+  L      D  + +  TALH AC  G  A+  +L+ AGA +   +   
Sbjct: 213 AAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272

Query: 187 STAIHWASRGGNLDV-LKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADL 245
            T +H A+   N  + L+LL+N GA ++ + K   + LH+A   G +  ++ LI   +++
Sbjct: 273 FTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEI 332

Query: 246 NAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVL 293
           +  D+ G+TPLH A R     +I  L+  GAD   +      P+ L +
Sbjct: 333 DCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV 380



 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 48/196 (24%), Positives = 88/196 (44%), Gaps = 21/196 (10%)

Query: 115 ITEPVD---VPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEK 171
           + +P D    P  + A   N    +E  +++  + +   +  ++ LH A + G     + 
Sbjct: 265 VNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQI 324

Query: 172 LMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGH 231
           L++ G++I+  D   +T +H A+R G+  ++  L+  GA  + R       LH+AV  G 
Sbjct: 325 LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGF 384

Query: 232 YECA------------------EHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM 273
            +C                   EH+++   D+N  D  G T LH A      + + LL+ 
Sbjct: 385 SDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLS 444

Query: 274 YGADLNIKNCAGKTPM 289
            GADL  ++  G+TP+
Sbjct: 445 SGADLRRRDKFGRTPL 460



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 43/143 (30%), Positives = 72/143 (50%), Gaps = 4/143 (2%)

Query: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
           D   RT LH A    +++ +  L++  A++   D    TA+  A+  G    ++ LL +G
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914

Query: 210 -AKISARDKLLSTALHVAVRTGHYECAEHLIACEADL---NAKDREGDTPLHDAVRLNRY 265
            A ++  D+  +TALH+A   GH +CA  ++A   DL   NA +     PLH A R    
Sbjct: 915 KADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLA 974

Query: 266 KMIRLLIMYGADLNIKNCAGKTP 288
            +++ L+ +GA +   +  G TP
Sbjct: 975 SVVQALLSHGATVLAVDEEGHTP 997



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 49/166 (29%), Positives = 81/166 (48%), Gaps = 10/166 (6%)

Query: 148 VCDEYK-RTALHRACLEGHLAIVEKLMEAGAQIEFRDMLES----TAIHWASRGGNLDVL 202
           +C ++K RT +H A   GH A++  L++A    +  D        + +HWAS  G+ D L
Sbjct: 748 LCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCL 807

Query: 203 KLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD--LNAKDREGDTPLHDAV 260
           +LLL   +  S  +    T LH AV        E L+       +N++D +G TPLH A 
Sbjct: 808 ELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAA 866

Query: 261 RLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
             +    +R+L+ + A++N  +  G+T   L+   +NG  A  + L
Sbjct: 867 FADNVSGLRMLLQHQAEVNATDHTGRTA--LMTAAENGQTAAVEFL 910



 Score = 58.5 bits (140), Expect = 7e-09
 Identities = 42/156 (26%), Positives = 70/156 (44%), Gaps = 8/156 (5%)

Query: 142 DKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDV 201
           D N PD      RT LH A   G++  +  L+ +GA +  RD    T +H+A+  G+   
Sbjct: 415 DINTPD---NLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQC 471

Query: 202 LKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVR 261
              L+  GA ++  D    + LH A  +  Y  AE         ++ D E D PL ++ R
Sbjct: 472 AVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE-----PHTPSSHDAEEDEPLKESRR 526

Query: 262 LNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              +  +  L+  GAD ++++  G T +     + N
Sbjct: 527 KEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGN 562



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 48/164 (29%), Positives = 75/164 (45%), Gaps = 6/164 (3%)

Query: 136 VEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQI--EFRDMLESTAIHWA 193
           +E  L +  +P + D    TA+H A   G+   +E L+E       +    +  + +H A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592

Query: 194 SRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGD 253
           +  G+ + LK L      +  RD    TAL +A   G  EC E L A  A    K+R+  
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652

Query: 254 -TPLHDAVRLNRYKMIRLLIMYG--ADL-NIKNCAGKTPMDLVL 293
            TPLH A        + LLI  G  AD+ ++ +  G+TP+ L +
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAI 696



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 4/151 (2%)

Query: 145 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLES-TAIHWASRGGNLDVLK 203
           N DV D   RTAL  A   G    VE L   GA    ++     T +H A+  G+ D L 
Sbjct: 610 NLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLH 669

Query: 204 LLLNKGAKISARDKLLS---TALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAV 260
           LL++ G +    D + +   T L +A+  GH +C   L+   +  +A D  G T LH   
Sbjct: 670 LLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGA 729

Query: 261 RLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
                  +  L+ + A +  ++  G+TP+ L
Sbjct: 730 VTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 760



 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 38/130 (29%), Positives = 57/130 (43%), Gaps = 4/130 (3%)

Query: 147 DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLL 206
           DV D Y +T L  A + GH+  V  L+E G+  +  D+   TA+H  +  G  D L  LL
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741

Query: 207 NKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN----AKDREGDTPLHDAVRL 262
           +  A +  RD    T +H+A   GH      L+      +      D  G +P+H A   
Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYT 801

Query: 263 NRYKMIRLLI 272
                + LL+
Sbjct: 802 GHEDCLELLL 811



 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 35/101 (34%), Positives = 49/101 (48%), Gaps = 7/101 (6%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPD--VCDEYKRTALHRACLEGH----LAIVEKLMEAG 176
           T L  A EN      +FL  +   D  V DE K TALH AC +GH    L I+ +  + G
Sbjct: 893 TALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLG 952

Query: 177 AQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDK 217
             I   +      +H A+R G   V++ LL+ GA + A D+
Sbjct: 953 L-INATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDE 992


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  100 bits (249), Expect = 2e-21
 Identities = 58/163 (35%), Positives = 89/163 (54%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA    +   E  +   +N +V D   RTALH A   GH  +V+ L+  GA I   D  +
Sbjct: 114 AAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD 173

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
             AIHWA+  G+++V+KLL++ GA+++ +DK   T LH A  +G     ++L+    D+N
Sbjct: 174 RRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMN 233

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
             +  G+TPLH A    +  ++  LI  GA +N KN  G TP+
Sbjct: 234 EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276



 Score = 88.6 bits (218), Expect = 7e-18
 Identities = 51/160 (31%), Positives = 83/160 (51%)

Query: 120 DVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQI 179
           D P+ ++A        V   +  K + +  D  KRT LH A   G   I+E L+ +GA++
Sbjct: 8   DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67

Query: 180 EFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLI 239
             +D    T +H A    + + +++LL   A ++ARDK   T LH+A      +CAE L+
Sbjct: 68  NAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV 127

Query: 240 ACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
              +++N  DR G T LH A      +M++LL+  GA++N
Sbjct: 128 PLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 51/171 (29%), Positives = 87/171 (50%), Gaps = 2/171 (1%)

Query: 136 VEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASR 195
           V+  L    + +  D+  +T LH A     +   E L+   + +   D    TA+H A+ 
Sbjct: 90  VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149

Query: 196 GGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTP 255
            G+ +++KLLL++GA I+A DK    A+H A   GH E  + L++  A++  KD++  TP
Sbjct: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209

Query: 256 LHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           LH A       +++ L+  G D+N  N  G TP+ +  +  NG   + + L
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACY--NGQDVVVNEL 258



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 53/171 (30%), Positives = 77/171 (45%), Gaps = 23/171 (13%)

Query: 157 LHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARD 216
           LH A L G      KL+ +G  I+  D    T +H A+ GGNL+ L LLLN GA  + +D
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435

Query: 217 KLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNR------------ 264
           K   + LH A    +Y+C   L+   A +N  D  G TPLH A   +             
Sbjct: 436 KFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRND 495

Query: 265 ----------YKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDS 305
                     Y  +     YG  L ++  A +TP+D+++   +GT  + DS
Sbjct: 496 ANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLME-TSGTDMLSDS 545



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 62/210 (29%), Positives = 91/210 (43%), Gaps = 40/210 (19%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           + L      V   L+   N D  D++ RTALHR  + GH   V+ L++ GA+   RD   
Sbjct: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRG 719

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISAR----DKLLSTALHVAVRTGHYECAEHLIACE 242
            T IH ++  G++ VL  LL   A + A     D    TALH A   GH  C E L+  E
Sbjct: 720 RTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQE 779

Query: 243 ----------------------------------ADLNAKDREGDTPLHDAVRLNRYKMI 268
                                             + +NA D +G TPLH A   +  + +
Sbjct: 780 VFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECL 839

Query: 269 RLLIMYGADLNIKNCAGKTPMDLVLHWQNG 298
           +LL+ + A +N  +  GKTP  L++  +NG
Sbjct: 840 QLLLSHNAQVNSVDSTGKTP--LMMAAENG 867



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 56/175 (32%), Positives = 87/175 (49%), Gaps = 10/175 (5%)

Query: 123 TFLKAALENKLPVVEKFLSD----KNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           T L AA  + +  V K+L D     N P+    Y  T LH AC  G   +V +L++ GA 
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGVDMNEPNA---YGNTPLHVACYNGQDVVVNELIDCGAI 264

Query: 179 IEFRDMLESTAIHWA--SRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAE 236
           +  ++    T +H+A  S  G L  L+LL+  GA ++ + K   T LH+    G +  ++
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGAL-CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323

Query: 237 HLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            +I   A ++ +D+ G+TPLH A R     +I  LI  GAD   +   G  P+ L
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378



 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 56/223 (25%), Positives = 99/223 (44%), Gaps = 36/223 (16%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA      +V+  LS   N +  D+  R A+H A   GH+ +V+ L+  GA++  +D   
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTG---------------- 230
            T +H A+  G + V+K LL+ G  ++  +   +T LHVA   G                
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266

Query: 231 ----------HYE--------CAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLI 272
                     H+         C E L+   AD+N K ++G TPLH      R+   + +I
Sbjct: 267 QKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII 326

Query: 273 MYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYKTSR 315
             GA ++ ++  G TP+ +   +  G + + ++L  +   T++
Sbjct: 327 QSGAVIDCEDKNGNTPLHIAARY--GHELLINTLITSGADTAK 367



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 47/143 (32%), Positives = 67/143 (46%)

Query: 147 DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLL 206
           D  D+   T LH A   GH  ++  L+ +GA    R +     +H A+  G  D  + LL
Sbjct: 333 DCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLL 392

Query: 207 NKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYK 266
           + G  I   D    T LH A   G+ EC   L+   AD N KD+ G +PLH A     Y+
Sbjct: 393 SSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQ 452

Query: 267 MIRLLIMYGADLNIKNCAGKTPM 289
            +  L+  GA +N  +  G TP+
Sbjct: 453 CLFALVGSGASVNDLDERGCTPL 475



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 56/201 (27%), Positives = 82/201 (40%), Gaps = 39/201 (19%)

Query: 147 DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD-MLESTAIHWASRGGNLDVLKLL 205
           DV +   RT L  A  +GH+  V+ L+  GA I  +D +L+ T IH A+  G+ + L+LL
Sbjct: 577 DVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636

Query: 206 ------------------------------------LNKGAKISARDKLLSTALHVAVRT 229
                                               LNKGA + A+DK   TALH    T
Sbjct: 637 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT 696

Query: 230 GHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           GH EC + L+   A    +D  G TP+H +       ++  L+   A ++          
Sbjct: 697 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG 756

Query: 290 DLVLHW--QNGTKAIFDSLRE 308
              LHW   NG +   + L E
Sbjct: 757 YTALHWACYNGHETCVELLLE 777



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 40/134 (29%), Positives = 72/134 (53%)

Query: 156 ALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISAR 215
           +L +A   G    V  L+     + F+D  + T +H A+  G+ ++++LL+  GA+++A+
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 216 DKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
           D    T LH AV +   E  + L+   AD+NA+D+   TPLH A      K    L+   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 276 ADLNIKNCAGKTPM 289
           +++N+ + AG+T +
Sbjct: 131 SNVNVSDRAGRTAL 144



 Score = 68.9 bits (167), Expect = 6e-12
 Identities = 40/136 (29%), Positives = 70/136 (51%)

Query: 154 RTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKIS 213
           +T LH   L G  +  + ++++GA I+  D   +T +H A+R G+  ++  L+  GA  +
Sbjct: 307 KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366

Query: 214 ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM 273
            R       LH+A  +G  +C   L++   D++  D  G T LH A      + + LL+ 
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426

Query: 274 YGADLNIKNCAGKTPM 289
            GAD N K+  G++P+
Sbjct: 427 TGADFNKKDKFGRSPL 442



 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 50/211 (23%), Positives = 86/211 (40%), Gaps = 46/211 (21%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL        K LS   + D  D++ RT LH A   G+L  +  L+  GA    +D   
Sbjct: 379 AALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTG-HYECAEHLIACEADL 245
            + +H+A+   N   L  L+  GA ++  D+   T LH A  +    +C E+L+  +A+ 
Sbjct: 439 RSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANP 498

Query: 246 NAKDREGD---------------------------------------------TPLHDAV 260
             +D++G                                              +PLH A 
Sbjct: 499 GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAA 558

Query: 261 RLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
               ++ + +L+    DL+++N +G+TP+DL
Sbjct: 559 YHGHHQALEVLVQSLLDLDVRNSSGRTPLDL 589



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 51/164 (31%), Positives = 76/164 (46%), Gaps = 10/164 (6%)

Query: 145 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTA---IHWASRGGNLDV 201
           NP   D +  TALH AC  GH   VE L+E     E     E  A   +H A    N   
Sbjct: 748 NPATADNHGYTALHWACYNGHETCVELLLEQ----EVFQKTEGNAFSPLHCAVINDNEGA 803

Query: 202 LKLLLNK-GAKI-SARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDA 259
            ++L++  GA I +A D    T LH A  T H EC + L++  A +N+ D  G TPL  A
Sbjct: 804 AEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMA 863

Query: 260 VRLNRYKMIRLLI-MYGADLNIKNCAGKTPMDLVLHWQNGTKAI 302
               +   + +L+    A+L +++ +  T + L     + T A+
Sbjct: 864 AENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSAL 907



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 41/137 (29%), Positives = 70/137 (51%), Gaps = 4/137 (2%)

Query: 157 LHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARD 216
           LH A   GH   +E L+++   ++ R+    T +  A+  G+++ + +L+N+GA I  +D
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613

Query: 217 KLLS-TALHVAVRTGHYECAEHLIACEADLNA---KDREGDTPLHDAVRLNRYKMIRLLI 272
            +L  T +H A   GH EC   LI      NA   +D  G TPL  +V       +  L+
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLL 673

Query: 273 MYGADLNIKNCAGKTPM 289
             GA+++ K+  G+T +
Sbjct: 674 NKGANVDAKDKWGRTAL 690



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 40/143 (27%), Positives = 69/143 (48%), Gaps = 4/143 (2%)

Query: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
           D   RT LH A    H+  ++ L+   AQ+   D    T +  A+  G  + +++L++  
Sbjct: 820 DSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSA 879

Query: 210 -AKISARDKLLSTALHVAVRTGHYECAEHLIACEAD---LNAKDREGDTPLHDAVRLNRY 265
            A+++ +D   +TALH+A   GH   A  ++    D   +NA +    TPLH A R    
Sbjct: 880 SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLT 939

Query: 266 KMIRLLIMYGADLNIKNCAGKTP 288
            +++ L+  GA +   +  G TP
Sbjct: 940 MVVQELLGKGASVLAVDENGYTP 962



 Score = 56.2 bits (134), Expect = 4e-08
 Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 4/134 (2%)

Query: 143 KNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVL 202
           +N  D+ D   +T L  + L GH   V  L+  GA ++ +D    TA+H  +  G+ + +
Sbjct: 643 QNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECV 702

Query: 203 KLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAK----DREGDTPLHD 258
             LL  GAK   RD    T +H++   GH      L+   A ++A     D  G T LH 
Sbjct: 703 DALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHW 762

Query: 259 AVRLNRYKMIRLLI 272
           A        + LL+
Sbjct: 763 ACYNGHETCVELLL 776



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 33/111 (29%), Positives = 58/111 (52%)

Query: 181 FRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIA 240
           F  + +  ++  A   G+ D ++ L+ K   ++ +D    T LH A   G  E  E LI 
Sbjct: 3   FLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLIL 62

Query: 241 CEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
             A +NAKD +  TPLH AV     + +++L+ + AD+N ++   +TP+ +
Sbjct: 63  SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHI 113



 Score = 48.5 bits (114), Expect = 8e-06
 Identities = 40/133 (30%), Positives = 60/133 (45%), Gaps = 4/133 (3%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLME-AGAQIEFRDML 185
           AA  + +  ++  LS     +  D   +T L  A   G    VE L+  A A++  +D  
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNS 889

Query: 186 ESTAIHWASRGGNLDVLKLLLNKGAK---ISARDKLLSTALHVAVRTGHYECAEHLIACE 242
           ++TA+H A   G+     L+L K      I+A +  L T LHVA R G     + L+   
Sbjct: 890 KNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKG 949

Query: 243 ADLNAKDREGDTP 255
           A + A D  G TP
Sbjct: 950 ASVLAVDENGYTP 962



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 37/146 (25%), Positives = 62/146 (42%), Gaps = 13/146 (8%)

Query: 150 DEYKRTALHRACL-EGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGN---------- 198
           DE   T LH A   +     +E L+   A    RD     A+H+++  G+          
Sbjct: 468 DERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASE 527

Query: 199 --LDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPL 256
             LDVL           + ++   + LH+A   GH++  E L+    DL+ ++  G TPL
Sbjct: 528 TPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPL 587

Query: 257 HDAVRLNRYKMIRLLIMYGADLNIKN 282
             A      + + +LI  GA + +K+
Sbjct: 588 DLAAFKGHVECVDVLINQGASILVKD 613


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 99.4 bits (246), Expect = 4e-21
 Identities = 72/255 (28%), Positives = 126/255 (49%), Gaps = 5/255 (1%)

Query: 40  EKQEDLKTLLAHPVTLGE--QQWKSEKQREAELKK-KKLEQRSKLENLEDLEIIIQLKKR 96
           +K+  ++  L HP    +  QQ  S K     ++K KK   R K +    L  + Q   R
Sbjct: 261 KKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSR 320

Query: 97  KKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTA 156
               ++ + V +  +     +   +   + A  ++ +P ++  L   +N DV    K   
Sbjct: 321 SFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGT 380

Query: 157 --LHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
             L  A   G++ I++ L++ G++I+ +D   S A++WA+R G++D LK L      +  
Sbjct: 381 PPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDV 440

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
           +DK    ALHVA R GH + A+ L +  ++ N +D+E +TPLH A     Y + + L   
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500

Query: 275 GADLNIKNCAGKTPM 289
           G ++NIKN  G+TP+
Sbjct: 501 GCNVNIKNREGETPL 515



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 51/165 (30%), Positives = 85/165 (51%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA      V +   S  +NP++ D+ + T LH A   G+ ++ + L EAG  +  ++   
Sbjct: 452 AARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREG 511

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +  AS  G  D+++ L   GA ++A DK    ALH+AVR    E  + L++    ++
Sbjct: 512 ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVD 571

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            +DR G+TPLH A +     ++  L     +L+I N  G+TP+ L
Sbjct: 572 YQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHL 616



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 50/153 (32%), Positives = 78/153 (50%), Gaps = 1/153 (0%)

Query: 138 KFLSDKNNP-DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRG 196
           KFLS+   P DV D+    ALH A   GH  + + L   G+    +D  E T +H A+  
Sbjct: 429 KFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488

Query: 197 GNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPL 256
           G   V K L   G  ++ +++   T L  A   G+++  E L    ADLNA D++G   L
Sbjct: 489 GYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIAL 548

Query: 257 HDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           H AVR  + ++I+ L+  G  ++ ++  G TP+
Sbjct: 549 HLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPL 581



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 1/169 (0%)

Query: 145 NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKL 204
           N ++ +    T L  A   G+  IVE L E GA +   D     A+H A R   ++V+K 
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKT 562

Query: 205 LLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNR 264
           LL++G  +  +D+  +T LHVA + G+      L     +L+  ++ G TPLH A     
Sbjct: 563 LLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGI 622

Query: 265 YKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKA-IFDSLRENSYK 312
             ++R L + GA +      GKT  DL    Q+   A +   LR+++++
Sbjct: 623 LDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 33/148 (22%), Positives = 65/148 (43%), Gaps = 1/148 (0%)

Query: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDM 184
           L A+      +VE       + + CD+    ALH A     + +++ L+  G  ++++D 
Sbjct: 516 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDR 575

Query: 185 LESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD 244
             +T +H A + GN+ ++  L      +   +K   T LH+A   G  +   +L    A 
Sbjct: 576 HGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGAS 635

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLI 272
           + A   +G T   D  R  +++ +  L+
Sbjct: 636 VEALTTDGKT-AEDLARSEQHEHVAGLL 662



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 36/121 (29%), Positives = 54/121 (44%), Gaps = 4/121 (3%)

Query: 132 KLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIH 191
           ++ V++  LS     D  D +  T LH AC +G++ IV  L EA   ++  +    T +H
Sbjct: 556 QMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLH 615

Query: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
            A+  G LDV++ L   GA + A    L+T    A      E  EH+    A L      
Sbjct: 616 LAANNGILDVVRYLCLMGASVEA----LTTDGKTAEDLARSEQHEHVAGLLARLRKDTHR 671

Query: 252 G 252
           G
Sbjct: 672 G 672


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 99.4 bits (246), Expect = 4e-21
 Identities = 57/163 (34%), Positives = 88/163 (53%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA    +   E  +   ++ +V D   RTALH A L GH+ +V  L+  GA I   D  +
Sbjct: 89  AAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKD 148

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
             A+HWA+  G+LDV+ LL+N GA+++ +DK   T LH A   G     +HL+    +++
Sbjct: 149 RRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID 208

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
             +  G+T LH A    +  ++  LI YGA++N  N  G TP+
Sbjct: 209 EINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPL 251



 Score = 90.9 bits (224), Expect = 1e-18
 Identities = 57/166 (34%), Positives = 88/166 (53%), Gaps = 1/166 (0%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL   + +V   L+   N +  D+  R ALH A   GHL +V  L+  GA++  +D   
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG 181

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+  G ++V+K LLN G +I   +   +TALH+A   G       LI   A++N
Sbjct: 182 YTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVN 241

Query: 247 AKDREGDTPLHDAVRLNRYKM-IRLLIMYGADLNIKNCAGKTPMDL 291
             +  G TPLH A       + + LL+  GAD+NI++  GK+P+ +
Sbjct: 242 QPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 49/146 (33%), Positives = 76/146 (52%), Gaps = 4/146 (2%)

Query: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
           D  KRT LH A   G   I+E L+ +GA++  +D +  T +H A    + + +++L+   
Sbjct: 13  DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72

Query: 210 AKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIR 269
           A ++ARDK   T LHVA      +CAE +I   + +N  DR G T LH A      +M+ 
Sbjct: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132

Query: 270 LLIMYGADLNIKNCAGKTPMDLVLHW 295
           LL+  GA++N  +   +      LHW
Sbjct: 133 LLLAKGANINAFDKKDRR----ALHW 154



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 53/177 (29%), Positives = 89/177 (50%), Gaps = 5/177 (2%)

Query: 130 ENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTA 189
           E  + V+ K  +D N     D+  +T LH A     +   E ++   + +   D    TA
Sbjct: 62  EEAVQVLIKHSADVN---ARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118

Query: 190 IHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKD 249
           +H A+  G+++++ LLL KGA I+A DK    ALH A   GH +    LI   A++  KD
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKD 178

Query: 250 REGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           ++G TPLH A    +  +++ L+  G +++  N  G T + +  +  NG  A+ + L
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACY--NGQDAVVNEL 233



 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 53/164 (32%), Positives = 74/164 (45%), Gaps = 12/164 (7%)

Query: 153 KRTALHRACLEGHLAIVEKLMEAGAQ---IEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
           KRT LH + + GH   +  L+E       ++ +D    T +  A   G++D + LLL K 
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668

Query: 210 AKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIR 269
           A +   D L  TALH  + TGH EC + L+  E  +  KD  G TPLH A        + 
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLS 728

Query: 270 LLIMYG---ADLNIKNCAGKTPMDLVLHW--QNGTKAIFDSLRE 308
            L+       D   K+  G TP    LHW   NG +   + L E
Sbjct: 729 ELLQMALSEEDCCFKDNQGYTP----LHWACYNGNENCIEVLLE 768



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 40/111 (36%), Positives = 56/111 (50%)

Query: 149 CDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNK 208
           C  +    LH A L  H     KL+ +G +I+  D    T +H A+ GGN++ +KLL + 
Sbjct: 343 CGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSS 402

Query: 209 GAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDA 259
           GA    +DK   T LH A    H+ C E L+   A++N  D  G T LH A
Sbjct: 403 GADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 52/174 (29%), Positives = 79/174 (45%), Gaps = 9/174 (5%)

Query: 147 DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLL 206
           D  D+   T LH A   GH  ++  L  +GA      +     +H A+   + D  + LL
Sbjct: 308 DCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLL 367

Query: 207 NKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYK 266
           + G +I   DK   T LH A   G+ EC + L +  AD + KD+ G TPLH A     + 
Sbjct: 368 SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFH 427

Query: 267 MIRLLIMYGADLNIKNCAGKTPMDLVLHW-----QNGTKAIFDSLRENSYKTSR 315
            I  L+  GA++N  +  G+T     LH+      +  K I  +  +NS +  R
Sbjct: 428 CIETLVTTGANVNETDDWGRT----ALHYAAASDMDRNKTILGNAHDNSEELER 477



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 50/153 (32%), Positives = 80/153 (52%), Gaps = 3/153 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA   ++ VV+  L+     D  + Y  TALH AC  G  A+V +L++ GA +   +   
Sbjct: 188 AASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNG 247

Query: 187 STAIHWA--SRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD 244
            T +H+A  S  G L  L+LL+N GA ++ + K   + LH+    G +  ++ LI    +
Sbjct: 248 FTPLHFAAASTHGAL-CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGE 306

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLIMYGAD 277
           ++  D++G+TPLH A R     +I  L   GAD
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 40/140 (28%), Positives = 70/140 (50%), Gaps = 4/140 (2%)

Query: 154 RTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKIS 213
           ++ LH A   GH   +E L+++   ++ RD    TA+  A+  G+ + ++ L+N GA I 
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF 602

Query: 214 ARDKLLS-TALHVAVRTGHYECAEHLIACEAD---LNAKDREGDTPLHDAVRLNRYKMIR 269
            +D +   T LH +V  GH  C   L+    +   ++ KD +G TPL  AV       + 
Sbjct: 603 VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662

Query: 270 LLIMYGADLNIKNCAGKTPM 289
           LL+   A+++  +  G T +
Sbjct: 663 LLLEKEANVDTVDILGCTAL 682



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 41/129 (31%), Positives = 59/129 (45%), Gaps = 3/129 (2%)

Query: 147 DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLL 206
           DV D   +T L  A   GH+  V  L+E  A ++  D+L  TA+H     G+ + +++LL
Sbjct: 639 DVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLL 698

Query: 207 NKGAKISARDKLLSTALHVAVRTGHYECAEHLI---ACEADLNAKDREGDTPLHDAVRLN 263
            +   I  +D    T LH A   GH      L+     E D   KD +G TPLH A    
Sbjct: 699 EQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNG 758

Query: 264 RYKMIRLLI 272
               I +L+
Sbjct: 759 NENCIEVLL 767



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 56/242 (23%), Positives = 92/242 (38%), Gaps = 47/242 (19%)

Query: 106 VVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGH 165
           +   PE   + +       + A     +  V   L  + N D  D    TALHR  + GH
Sbjct: 631 IADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGH 690

Query: 166 LAIVEKLMEAGAQIE------------------------------------FRDMLESTA 189
              V+ L+E    I                                     F+D    T 
Sbjct: 691 EECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTP 750

Query: 190 IHWASRGGNLDVLKLLLNKGAKISARDKLLS---TALHVAVRTGHYECAEHLIAC--EAD 244
           +HWA   GN + +++LL +        K +    T LH A+   H  CA  L+     + 
Sbjct: 751 LHWACYNGNENCIEVLLEQ----KCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSI 806

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFD 304
           ++ +D +G TPL  A   +  + ++LL+ + A +N  + +GKT   L++  +NG     D
Sbjct: 807 VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTA--LMMAAENGQAGAVD 864

Query: 305 SL 306
            L
Sbjct: 865 IL 866



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 41/174 (23%), Positives = 69/174 (39%), Gaps = 28/174 (16%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL        K LS     D  D++ RT LH A   G++  ++ L  +GA    +D   
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYE------------- 233
            T +H+A+   +   ++ L+  GA ++  D    TALH A  +                 
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSE 473

Query: 234 ---------------CAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLI 272
                          C E L+  +A+ + +D+EG   +H A      + + LL+
Sbjct: 474 ELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 48/175 (27%), Positives = 72/175 (41%), Gaps = 36/175 (20%)

Query: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRG---------GNLD 200
           D+  RT LH A    H   +E L+  GA +   D    TA+H+A+           GN  
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAH 469

Query: 201 -------------------VLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIAC 241
                               L+ LL   A  S RDK    ++H A   GH +C E L+  
Sbjct: 470 DNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL-- 527

Query: 242 EADLNAKDREGD-----TPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
               N+   E D     +PLH A     ++ + +L+    DL+I++  G+T +DL
Sbjct: 528 -ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 35/99 (35%), Positives = 51/99 (51%), Gaps = 4/99 (4%)

Query: 204 LLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLN 263
           +L++K   ++  D    T LHVA   G  E  E LI   A +NAKD    TPLH AV   
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 264 RYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAI 302
             + +++LI + AD+N ++   +TP    LH     KA+
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTP----LHVAAANKAV 95



 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 46/180 (25%), Positives = 69/180 (38%), Gaps = 38/180 (21%)

Query: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIE---FRDMLESTAIHWASRGGNLDVLKLLL 206
           D   RT LH A   GH   + +L++     E   F+D    T +HWA   GN + +++LL
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767

Query: 207 NK----------------------------------GAKISARDKLLSTALHVAVRTGHY 232
            +                                   + +S RD    T L  A    H 
Sbjct: 768 EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHV 827

Query: 233 ECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG-ADLNIKNCAGKTPMDL 291
           EC + L+   A +NA D  G T L  A    +   + +L+    ADL +K+    TP+ L
Sbjct: 828 ECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 42/139 (30%), Positives = 66/139 (47%), Gaps = 6/139 (4%)

Query: 155 TALHRACLEGHLAIVEKLMEA--GAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKI 212
           T LH A +  H      L+ A   + +  RD    T +  A+   +++ L+LLL   A +
Sbjct: 781 TPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840

Query: 213 SARDKLLSTALHVAVRTGHYECAEHLI-ACEADLNAKDREGDTPLHDAVRLNRYKMIRLL 271
           +A D    TAL +A   G     + L+ + +ADL  KD++ +TPLH A      K   L+
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLI 900

Query: 272 IMYGAD---LNIKNCAGKT 287
           +    D   +N KN A +T
Sbjct: 901 LDKIQDESLINEKNNALQT 919



 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 1/87 (1%)

Query: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
           D+  RT L  A    H+  ++ L+   A +   D    TA+  A+  G    + +L+N  
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSA 870

Query: 210 -AKISARDKLLSTALHVAVRTGHYECA 235
            A ++ +DK L+T LH+A   GH +CA
Sbjct: 871 QADLTVKDKDLNTPLHLACSKGHEKCA 897


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 51/137 (37%), Positives = 82/137 (59%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH AC + H+ ++E L++ GA I+       T +H AS  G+L ++K LL +GA  + 
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
            +  + T LH+A R GH E A++L+  +A +NAK ++  TPLH A R+    M++LL+  
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 525

Query: 275 GADLNIKNCAGKTPMDL 291
            A+ N+   AG TP+ +
Sbjct: 526 NANPNLATTAGHTPLHI 542



 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 56/176 (31%), Positives = 89/176 (50%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           V +P    AA  +        L +  NPDV  +   T LH A    +L + + L+  GA 
Sbjct: 205 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 264

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + F      T +H ASR GN+ +++LLL++GA+I  + K   T LH A R GH   +E L
Sbjct: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294
           +   A + AK + G +P+H A + +    +RLL+ Y A+++       TP+ +  H
Sbjct: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 380



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 61/228 (26%), Positives = 115/228 (50%), Gaps = 9/228 (3%)

Query: 100 RKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHR 159
           R   V +  +P P+++++    P  + A  EN L V +  L+   + +   +   T LH 
Sbjct: 220 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHI 278

Query: 160 ACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLL 219
           A   G++ +V  L++ GAQIE +   E T +H A+R G++ + ++LL+ GA I A+ K  
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338

Query: 220 STALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
            + +H+A +  H +C   L+  +A+++    +  TPLH A     +++ ++L+  GA  N
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398

Query: 280 IKNCAGKTPMDL--------VLHWQNGTKAIFDSLRENSYKTSRIATF 319
            +   G TP+ +        V+     T A  D++ E+      +A+F
Sbjct: 399 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 446



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 51/171 (29%), Positives = 84/171 (49%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A+    LP+V+  L    +P+V +    T LH A   GH  + + L++  A++  +   +
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +++KLLL   A  +       T LH+A R GH E    L+  EA   
Sbjct: 504 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 563

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              ++G TPLH A +  + ++  LL+   A  N     G TP+ + +H  N
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 614



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/163 (33%), Positives = 77/163 (47%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A  +N + V+E  L    + D   E   T LH A   GHL IV+ L++ GA     ++  
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +V K LL   AK++A+ K   T LH A R GH    + L+   A+ N
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
                G TPLH A R    + +  L+   A        G TP+
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 2/221 (0%)

Query: 73  KKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVP-VVKEPEPEIITEPVDVPTFLKAALE- 130
           K L QR    N+ ++++   L    +   T+V   + + + ++  +  D  T L  A   
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513

Query: 131 NKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI 190
               +V+  L +  NP++      T LH A  EGH+  V  L+E  A          T +
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 573

Query: 191 HWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDR 250
           H A++ G + V +LLL + A  +A  K   T LHVAV   + +  + L+      ++   
Sbjct: 574 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 633

Query: 251 EGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            G TPLH A + N+ ++ R L+ YG   N ++  G TP+ L
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 674



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 47/163 (28%), Positives = 79/163 (48%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ V    L    + +       T LH A  EGH  +V  L+   A     +   
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H  ++ G++ V  +L+  G  + A  ++  T LHVA   G+ +  + L+  +AD+N
Sbjct: 702 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 761

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           AK + G +PLH A +     ++ LL+  GA  N  +  G TP+
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 51/192 (26%), Positives = 88/192 (45%), Gaps = 2/192 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A   N L +V+  L    +P        T LH A  +  + +   L++ G       +  
Sbjct: 609 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 668

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++ G+ +++ LLL+K A  +  +K   T LH+  + GH   A+ LI     ++
Sbjct: 669 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 728

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           A  R G TPLH A      K+++ L+ + AD+N K   G +P+      Q G   I   L
Sbjct: 729 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA--QQGHTDIVTLL 786

Query: 307 RENSYKTSRIAT 318
            +N    + +++
Sbjct: 787 LKNGASPNEVSS 798



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 57/212 (26%), Positives = 98/212 (46%), Gaps = 15/212 (7%)

Query: 65  QREAELKK-KKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVPVVKEPEPEIITEPVDVPT 123
           Q   +LKK K +E ++  E  E  E   + + R + RK K                   +
Sbjct: 3   QAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAAT--------------S 48

Query: 124 FLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD 183
           FL+AA    L      L +  + + C++     LH A  EGH+ +V +L+     +E   
Sbjct: 49  FLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 108

Query: 184 MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
              +TA+H A+  G  +V++ L+N GA ++A+ +   T L++A +  H E  + L+   A
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168

Query: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
           + N    +G TPL  A++     ++  LI YG
Sbjct: 169 NQNVATEDGFTPLAVALQQGHENVVAHLINYG 200



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 1/180 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNP-DVCDEYKRTALHRACLEGHLAIVEK 171
           +I T+  D  T L  A  N    + + L D   P     +   + +H A    HL  V  
Sbjct: 297 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 356

Query: 172 LMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGH 231
           L++  A+I+   +   T +H A+  G+  V K+LL+KGAK ++R     T LH+A +  H
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 416

Query: 232 YECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
               E L+   A ++A    G TPLH A  +    +++ L+  GA  N+ N   +TP+ +
Sbjct: 417 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 43/136 (31%), Positives = 69/136 (50%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E    +V   LS + N ++ ++   T LH    EGH+ + + L++ G  ++    + 
Sbjct: 675 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H AS  GN+ ++K LL   A ++A+ KL  + LH A + GH +    L+   A  N
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794

Query: 247 AKDREGDTPLHDAVRL 262
               +G TPL  A RL
Sbjct: 795 EVSSDGTTPLAIAKRL 810



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/139 (28%), Positives = 71/139 (51%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T+  RA   G+L      +  G  I   +      +H AS+ G++ ++  LL+K   +  
Sbjct: 47  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K  +TALH+A   G  E    L+   A++NA+ ++G TPL+ A + N  ++++ L+  
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166

Query: 275 GADLNIKNCAGKTPMDLVL 293
           GA+ N+    G TP+ + L
Sbjct: 167 GANQNVATEDGFTPLAVAL 185



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 4/165 (2%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL  +  VV + ++   N +   +   T L+ A  E HL +V+ L+E GA         
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +  A + G+ +V+  L+N G K     K+   ALH+A R      A  L+  + + +
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPD 233

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
              + G TPLH A       + +LL+  GA +N     G TP+ +
Sbjct: 234 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 32/103 (31%), Positives = 55/103 (53%)

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
           +T+   A+R GNLD     L  G  I+  ++     LH+A + GH +    L+  E  L 
Sbjct: 46  ATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILE 105

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
              ++G+T LH A    + +++R L+ YGA++N ++  G TP+
Sbjct: 106 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 148



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 29/111 (26%), Positives = 52/111 (46%)

Query: 128 ALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLES 187
           A E  +PV +  +      D       T LH A   G++ +V+ L++  A +  +  L  
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768

Query: 188 TAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + +H A++ G+ D++ LLL  GA  +      +T L +A R G+    + L
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 51/137 (37%), Positives = 82/137 (59%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH AC + H+ ++E L++ GA I+       T +H AS  G+L ++K LL +GA  + 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
            +  + T LH+A R GH E A++L+  +A +NAK ++  TPLH A R+    M++LL+  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 275 GADLNIKNCAGKTPMDL 291
            A+ N+   AG TP+ +
Sbjct: 493 NANPNLATTAGHTPLHI 509



 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 56/176 (31%), Positives = 89/176 (50%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           V +P    AA  +        L +  NPDV  +   T LH A    +L + + L+  GA 
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + F      T +H ASR GN+ +++LLL++GA+I  + K   T LH A R GH   +E L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294
           +   A + AK + G +P+H A + +    +RLL+ Y A+++       TP+ +  H
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 61/228 (26%), Positives = 115/228 (50%), Gaps = 9/228 (3%)

Query: 100 RKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHR 159
           R   V +  +P P+++++    P  + A  EN L V +  L+   + +   +   T LH 
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHI 245

Query: 160 ACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLL 219
           A   G++ +V  L++ GAQIE +   E T +H A+R G++ + ++LL+ GA I A+ K  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 220 STALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
            + +H+A +  H +C   L+  +A+++    +  TPLH A     +++ ++L+  GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 280 IKNCAGKTPMDL--------VLHWQNGTKAIFDSLRENSYKTSRIATF 319
            +   G TP+ +        V+     T A  D++ E+      +A+F
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 413



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 51/171 (29%), Positives = 84/171 (49%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A+    LP+V+  L    +P+V +    T LH A   GH  + + L++  A++  +   +
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +++KLLL   A  +       T LH+A R GH E    L+  EA   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              ++G TPLH A +  + ++  LL+   A  N     G TP+ + +H  N
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/163 (33%), Positives = 77/163 (47%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A  +N + V+E  L    + D   E   T LH A   GHL IV+ L++ GA     ++  
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +V K LL   AK++A+ K   T LH A R GH    + L+   A+ N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
                G TPLH A R    + +  L+   A        G TP+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 2/221 (0%)

Query: 73  KKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVP-VVKEPEPEIITEPVDVPTFLKAALE- 130
           K L QR    N+ ++++   L    +   T+V   + + + ++  +  D  T L  A   
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 131 NKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI 190
               +V+  L +  NP++      T LH A  EGH+  V  L+E  A          T +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 191 HWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDR 250
           H A++ G + V +LLL + A  +A  K   T LHVAV   + +  + L+      ++   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 251 EGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            G TPLH A + N+ ++ R L+ YG   N ++  G TP+ L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 47/163 (28%), Positives = 79/163 (48%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ V    L    + +       T LH A  EGH  +V  L+   A     +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H  ++ G++ V  +L+  G  + A  ++  T LHVA   G+ +  + L+  +AD+N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           AK + G +PLH A +     ++ LL+  GA  N  +  G TP+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 51/192 (26%), Positives = 88/192 (45%), Gaps = 2/192 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A   N L +V+  L    +P        T LH A  +  + +   L++ G       +  
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++ G+ +++ LLL+K A  +  +K   T LH+  + GH   A+ LI     ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           A  R G TPLH A      K+++ L+ + AD+N K   G +P+      Q G   I   L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA--QQGHTDIVTLL 753

Query: 307 RENSYKTSRIAT 318
            +N    + +++
Sbjct: 754 LKNGASPNEVSS 765



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 1/180 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNP-DVCDEYKRTALHRACLEGHLAIVEK 171
           +I T+  D  T L  A  N    + + L D   P     +   + +H A    HL  V  
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 172 LMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGH 231
           L++  A+I+   +   T +H A+  G+  V K+LL+KGAK ++R     T LH+A +  H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 232 YECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
               E L+   A ++A    G TPLH A  +    +++ L+  GA  N+ N   +TP+ +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 44/153 (28%), Positives = 78/153 (50%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFR 182
           +FL+AA    L      L +  + + C++     LH A  EGH+ +V +L+     +E  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 183 DMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
               +TA+H A+  G  +V++ L+N GA ++A+ +   T L++A +  H E  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 243 ADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
           A+ N    +G TPL  A++     ++  LI YG
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 43/136 (31%), Positives = 69/136 (50%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E    +V   LS + N ++ ++   T LH    EGH+ + + L++ G  ++    + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H AS  GN+ ++K LL   A ++A+ KL  + LH A + GH +    L+   A  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 247 AKDREGDTPLHDAVRL 262
               +G TPL  A RL
Sbjct: 762 EVSSDGTTPLAIAKRL 777



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/139 (28%), Positives = 71/139 (51%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T+  RA   G+L      +  G  I   +      +H AS+ G++ ++  LL+K   +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K  +TALH+A   G  E    L+   A++NA+ ++G TPL+ A + N  ++++ L+  
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 275 GADLNIKNCAGKTPMDLVL 293
           GA+ N+    G TP+ + L
Sbjct: 134 GANQNVATEDGFTPLAVAL 152



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 4/165 (2%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL  +  VV + ++   N +   +   T L+ A  E HL +V+ L+E GA         
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +  A + G+ +V+  L+N G K     K+   ALH+A R      A  L+  + + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
              + G TPLH A       + +LL+  GA +N     G TP+ +
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 34/111 (30%), Positives = 59/111 (53%)

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + FR+   +T+   A+R GNLD     L  G  I+  ++     LH+A + GH +    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           +  E  L    ++G+T LH A    + +++R L+ YGA++N ++  G TP+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 29/111 (26%), Positives = 52/111 (46%)

Query: 128 ALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLES 187
           A E  +PV +  +      D       T LH A   G++ +V+ L++  A +  +  L  
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 188 TAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + +H A++ G+ D++ LLL  GA  +      +T L +A R G+    + L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 51/137 (37%), Positives = 82/137 (59%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH AC + H+ ++E L++ GA I+       T +H AS  G+L ++K LL +GA  + 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
            +  + T LH+A R GH E A++L+  +A +NAK ++  TPLH A R+    M++LL+  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 275 GADLNIKNCAGKTPMDL 291
            A+ N+   AG TP+ +
Sbjct: 493 NANPNLATTAGHTPLHI 509



 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 56/176 (31%), Positives = 89/176 (50%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           V +P    AA  +        L +  NPDV  +   T LH A    +L + + L+  GA 
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + F      T +H ASR GN+ +++LLL++GA+I  + K   T LH A R GH   +E L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294
           +   A + AK + G +P+H A + +    +RLL+ Y A+++       TP+ +  H
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 61/228 (26%), Positives = 115/228 (50%), Gaps = 9/228 (3%)

Query: 100 RKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHR 159
           R   V +  +P P+++++    P  + A  EN L V +  L+   + +   +   T LH 
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHI 245

Query: 160 ACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLL 219
           A   G++ +V  L++ GAQIE +   E T +H A+R G++ + ++LL+ GA I A+ K  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 220 STALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
            + +H+A +  H +C   L+  +A+++    +  TPLH A     +++ ++L+  GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 280 IKNCAGKTPMDL--------VLHWQNGTKAIFDSLRENSYKTSRIATF 319
            +   G TP+ +        V+     T A  D++ E+      +A+F
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 413



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 51/171 (29%), Positives = 84/171 (49%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A+    LP+V+  L    +P+V +    T LH A   GH  + + L++  A++  +   +
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +++KLLL   A  +       T LH+A R GH E    L+  EA   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              ++G TPLH A +  + ++  LL+   A  N     G TP+ + +H  N
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/163 (33%), Positives = 77/163 (47%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A  +N + V+E  L    + D   E   T LH A   GHL IV+ L++ GA     ++  
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +V K LL   AK++A+ K   T LH A R GH    + L+   A+ N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
                G TPLH A R    + +  L+   A        G TP+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 2/221 (0%)

Query: 73  KKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVP-VVKEPEPEIITEPVDVPTFLKAALE- 130
           K L QR    N+ ++++   L    +   T+V   + + + ++  +  D  T L  A   
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 131 NKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI 190
               +V+  L +  NP++      T LH A  EGH+  V  L+E  A          T +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 191 HWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDR 250
           H A++ G + V +LLL + A  +A  K   T LHVAV   + +  + L+      ++   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 251 EGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            G TPLH A + N+ ++ R L+ YG   N ++  G TP+ L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 47/163 (28%), Positives = 79/163 (48%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ V    L    + +       T LH A  EGH  +V  L+   A     +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H  ++ G++ V  +L+  G  + A  ++  T LHVA   G+ +  + L+  +AD+N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           AK + G +PLH A +     ++ LL+  GA  N  +  G TP+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 51/192 (26%), Positives = 88/192 (45%), Gaps = 2/192 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A   N L +V+  L    +P        T LH A  +  + +   L++ G       +  
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++ G+ +++ LLL+K A  +  +K   T LH+  + GH   A+ LI     ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           A  R G TPLH A      K+++ L+ + AD+N K   G +P+      Q G   I   L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA--QQGHTDIVTLL 753

Query: 307 RENSYKTSRIAT 318
            +N    + +++
Sbjct: 754 LKNGASPNEVSS 765



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 1/180 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNP-DVCDEYKRTALHRACLEGHLAIVEK 171
           +I T+  D  T L  A  N    + + L D   P     +   + +H A    HL  V  
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 172 LMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGH 231
           L++  A+I+   +   T +H A+  G+  V K+LL+KGAK ++R     T LH+A +  H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 232 YECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
               E L+   A ++A    G TPLH A  +    +++ L+  GA  N+ N   +TP+ +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 44/153 (28%), Positives = 78/153 (50%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFR 182
           +FL+AA    L      L +  + + C++     LH A  EGH+ +V +L+     +E  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 183 DMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
               +TA+H A+  G  +V++ L+N GA ++A+ +   T L++A +  H E  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 243 ADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
           A+ N    +G TPL  A++     ++  LI YG
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 43/136 (31%), Positives = 69/136 (50%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E    +V   LS + N ++ ++   T LH    EGH+ + + L++ G  ++    + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H AS  GN+ ++K LL   A ++A+ KL  + LH A + GH +    L+   A  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 247 AKDREGDTPLHDAVRL 262
               +G TPL  A RL
Sbjct: 762 EVSSDGTTPLAIAKRL 777



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/139 (28%), Positives = 71/139 (51%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T+  RA   G+L      +  G  I   +      +H AS+ G++ ++  LL+K   +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K  +TALH+A   G  E    L+   A++NA+ ++G TPL+ A + N  ++++ L+  
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 275 GADLNIKNCAGKTPMDLVL 293
           GA+ N+    G TP+ + L
Sbjct: 134 GANQNVATEDGFTPLAVAL 152



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 4/165 (2%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL  +  VV + ++   N +   +   T L+ A  E HL +V+ L+E GA         
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +  A + G+ +V+  L+N G K     K+   ALH+A R      A  L+  + + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
              + G TPLH A       + +LL+  GA +N     G TP+ +
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 34/111 (30%), Positives = 59/111 (53%)

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + FR+   +T+   A+R GNLD     L  G  I+  ++     LH+A + GH +    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           +  E  L    ++G+T LH A    + +++R L+ YGA++N ++  G TP+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 29/111 (26%), Positives = 52/111 (46%)

Query: 128 ALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLES 187
           A E  +PV +  +      D       T LH A   G++ +V+ L++  A +  +  L  
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 188 TAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + +H A++ G+ D++ LLL  GA  +      +T L +A R G+    + L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 51/137 (37%), Positives = 82/137 (59%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH AC + H+ ++E L++ GA I+       T +H AS  G+L ++K LL +GA  + 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
            +  + T LH+A R GH E A++L+  +A +NAK ++  TPLH A R+    M++LL+  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 275 GADLNIKNCAGKTPMDL 291
            A+ N+   AG TP+ +
Sbjct: 493 NANPNLATTAGHTPLHI 509



 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 56/176 (31%), Positives = 89/176 (50%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           V +P    AA  +        L +  NPDV  +   T LH A    +L + + L+  GA 
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + F      T +H ASR GN+ +++LLL++GA+I  + K   T LH A R GH   +E L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294
           +   A + AK + G +P+H A + +    +RLL+ Y A+++       TP+ +  H
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 61/228 (26%), Positives = 115/228 (50%), Gaps = 9/228 (3%)

Query: 100 RKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHR 159
           R   V +  +P P+++++    P  + A  EN L V +  L+   + +   +   T LH 
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHI 245

Query: 160 ACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLL 219
           A   G++ +V  L++ GAQIE +   E T +H A+R G++ + ++LL+ GA I A+ K  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 220 STALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
            + +H+A +  H +C   L+  +A+++    +  TPLH A     +++ ++L+  GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 280 IKNCAGKTPMDL--------VLHWQNGTKAIFDSLRENSYKTSRIATF 319
            +   G TP+ +        V+     T A  D++ E+      +A+F
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 413



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 51/171 (29%), Positives = 84/171 (49%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A+    LP+V+  L    +P+V +    T LH A   GH  + + L++  A++  +   +
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +++KLLL   A  +       T LH+A R GH E    L+  EA   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              ++G TPLH A +  + ++  LL+   A  N     G TP+ + +H  N
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/163 (33%), Positives = 77/163 (47%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A  +N + V+E  L    + D   E   T LH A   GHL IV+ L++ GA     ++  
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +V K LL   AK++A+ K   T LH A R GH    + L+   A+ N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
                G TPLH A R    + +  L+   A        G TP+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 2/221 (0%)

Query: 73  KKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVP-VVKEPEPEIITEPVDVPTFLKAALE- 130
           K L QR    N+ ++++   L    +   T+V   + + + ++  +  D  T L  A   
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 131 NKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI 190
               +V+  L +  NP++      T LH A  EGH+  V  L+E  A          T +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 191 HWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDR 250
           H A++ G + V +LLL + A  +A  K   T LHVAV   + +  + L+      ++   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 251 EGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            G TPLH A + N+ ++ R L+ YG   N ++  G TP+ L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 47/163 (28%), Positives = 79/163 (48%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ V    L    + +       T LH A  EGH  +V  L+   A     +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H  ++ G++ V  +L+  G  + A  ++  T LHVA   G+ +  + L+  +AD+N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           AK + G +PLH A +     ++ LL+  GA  N  +  G TP+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 51/192 (26%), Positives = 88/192 (45%), Gaps = 2/192 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A   N L +V+  L    +P        T LH A  +  + +   L++ G       +  
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++ G+ +++ LLL+K A  +  +K   T LH+  + GH   A+ LI     ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           A  R G TPLH A      K+++ L+ + AD+N K   G +P+      Q G   I   L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA--QQGHTDIVTLL 753

Query: 307 RENSYKTSRIAT 318
            +N    + +++
Sbjct: 754 LKNGASPNEVSS 765



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 1/180 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNP-DVCDEYKRTALHRACLEGHLAIVEK 171
           +I T+  D  T L  A  N    + + L D   P     +   + +H A    HL  V  
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 172 LMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGH 231
           L++  A+I+   +   T +H A+  G+  V K+LL+KGAK ++R     T LH+A +  H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 232 YECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
               E L+   A ++A    G TPLH A  +    +++ L+  GA  N+ N   +TP+ +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 44/153 (28%), Positives = 78/153 (50%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFR 182
           +FL+AA    L      L +  + + C++     LH A  EGH+ +V +L+     +E  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 183 DMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
               +TA+H A+  G  +V++ L+N GA ++A+ +   T L++A +  H E  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 243 ADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
           A+ N    +G TPL  A++     ++  LI YG
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 43/136 (31%), Positives = 69/136 (50%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E    +V   LS + N ++ ++   T LH    EGH+ + + L++ G  ++    + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H AS  GN+ ++K LL   A ++A+ KL  + LH A + GH +    L+   A  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 247 AKDREGDTPLHDAVRL 262
               +G TPL  A RL
Sbjct: 762 EVSSDGTTPLAIAKRL 777



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/139 (28%), Positives = 71/139 (51%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T+  RA   G+L      +  G  I   +      +H AS+ G++ ++  LL+K   +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K  +TALH+A   G  E    L+   A++NA+ ++G TPL+ A + N  ++++ L+  
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 275 GADLNIKNCAGKTPMDLVL 293
           GA+ N+    G TP+ + L
Sbjct: 134 GANQNVATEDGFTPLAVAL 152



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 4/165 (2%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL  +  VV + ++   N +   +   T L+ A  E HL +V+ L+E GA         
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +  A + G+ +V+  L+N G K     K+   ALH+A R      A  L+  + + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
              + G TPLH A       + +LL+  GA +N     G TP+ +
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 34/111 (30%), Positives = 59/111 (53%)

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + FR+   +T+   A+R GNLD     L  G  I+  ++     LH+A + GH +    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           +  E  L    ++G+T LH A    + +++R L+ YGA++N ++  G TP+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 29/111 (26%), Positives = 52/111 (46%)

Query: 128 ALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLES 187
           A E  +PV +  +      D       T LH A   G++ +V+ L++  A +  +  L  
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 188 TAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + +H A++ G+ D++ LLL  GA  +      +T L +A R G+    + L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 51/137 (37%), Positives = 82/137 (59%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH AC + H+ ++E L++ GA I+       T +H AS  G+L ++K LL +GA  + 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
            +  + T LH+A R GH E A++L+  +A +NAK ++  TPLH A R+    M++LL+  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 275 GADLNIKNCAGKTPMDL 291
            A+ N+   AG TP+ +
Sbjct: 493 NANPNLATTAGHTPLHI 509



 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 56/176 (31%), Positives = 89/176 (50%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           V +P    AA  +        L +  NPDV  +   T LH A    +L + + L+  GA 
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + F      T +H ASR GN+ +++LLL++GA+I  + K   T LH A R GH   +E L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294
           +   A + AK + G +P+H A + +    +RLL+ Y A+++       TP+ +  H
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAH 347



 Score = 90.1 bits (222), Expect = 2e-18
 Identities = 61/228 (26%), Positives = 115/228 (50%), Gaps = 9/228 (3%)

Query: 100 RKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHR 159
           R   V +  +P P+++++    P  + A  EN L V +  L+   + +   +   T LH 
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHI 245

Query: 160 ACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLL 219
           A   G++ +V  L++ GAQIE +   E T +H A+R G++ + ++LL+ GA I A+ K  
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 220 STALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
            + +H+A +  H +C   L+  +A+++    +  TPLH A     +++ ++L+  GA  N
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 280 IKNCAGKTPMDL--------VLHWQNGTKAIFDSLRENSYKTSRIATF 319
            +   G TP+ +        V+     T A  D++ E+      +A+F
Sbjct: 366 SRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASF 413



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 51/171 (29%), Positives = 84/171 (49%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A+    LP+V+  L    +P+V +    T LH A   GH  + + L++  A++  +   +
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +++KLLL   A  +       T LH+A R GH E    L+  EA   
Sbjct: 471 QTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQA 530

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              ++G TPLH A +  + ++  LL+   A  N     G TP+ + +H  N
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581



 Score = 82.4 bits (202), Expect = 5e-16
 Identities = 54/163 (33%), Positives = 77/163 (47%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A  +N + V+E  L    + D   E   T LH A   GHL IV+ L++ GA     ++  
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A+R G+ +V K LL   AK++A+ K   T LH A R GH    + L+   A+ N
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
                G TPLH A R    + +  L+   A        G TP+
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 61/221 (27%), Positives = 102/221 (46%), Gaps = 2/221 (0%)

Query: 73  KKLEQRSKLENLEDLEIIIQLKKRKKYRKTKVP-VVKEPEPEIITEPVDVPTFLKAALE- 130
           K L QR    N+ ++++   L    +   T+V   + + + ++  +  D  T L  A   
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480

Query: 131 NKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI 190
               +V+  L +  NP++      T LH A  EGH+  V  L+E  A          T +
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPL 540

Query: 191 HWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDR 250
           H A++ G + V +LLL + A  +A  K   T LHVAV   + +  + L+      ++   
Sbjct: 541 HVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW 600

Query: 251 EGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            G TPLH A + N+ ++ R L+ YG   N ++  G TP+ L
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 47/163 (28%), Positives = 79/163 (48%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ V    L    + +       T LH A  EGH  +V  L+   A     +   
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H  ++ G++ V  +L+  G  + A  ++  T LHVA   G+ +  + L+  +AD+N
Sbjct: 669 LTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVN 728

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           AK + G +PLH A +     ++ LL+  GA  N  +  G TP+
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 51/192 (26%), Positives = 88/192 (45%), Gaps = 2/192 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A   N L +V+  L    +P        T LH A  +  + +   L++ G       +  
Sbjct: 576 AVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQG 635

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++ G+ +++ LLL+K A  +  +K   T LH+  + GH   A+ LI     ++
Sbjct: 636 VTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD 695

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           A  R G TPLH A      K+++ L+ + AD+N K   G +P+      Q G   I   L
Sbjct: 696 ATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA--QQGHTDIVTLL 753

Query: 307 RENSYKTSRIAT 318
            +N    + +++
Sbjct: 754 LKNGASPNEVSS 765



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 53/180 (29%), Positives = 86/180 (47%), Gaps = 1/180 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNP-DVCDEYKRTALHRACLEGHLAIVEK 171
           +I T+  D  T L  A  N    + + L D   P     +   + +H A    HL  V  
Sbjct: 264 QIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 172 LMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGH 231
           L++  A+I+   +   T +H A+  G+  V K+LL+KGAK ++R     T LH+A +  H
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNH 383

Query: 232 YECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
               E L+   A ++A    G TPLH A  +    +++ L+  GA  N+ N   +TP+ +
Sbjct: 384 VRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 44/153 (28%), Positives = 78/153 (50%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFR 182
           +FL+AA    L      L +  + + C++     LH A  EGH+ +V +L+     +E  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 183 DMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
               +TA+H A+  G  +V++ L+N GA ++A+ +   T L++A +  H E  + L+   
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 243 ADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
           A+ N    +G TPL  A++     ++  LI YG
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 43/136 (31%), Positives = 69/136 (50%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E    +V   LS + N ++ ++   T LH    EGH+ + + L++ G  ++    + 
Sbjct: 642 AAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H AS  GN+ ++K LL   A ++A+ KL  + LH A + GH +    L+   A  N
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761

Query: 247 AKDREGDTPLHDAVRL 262
               +G TPL  A RL
Sbjct: 762 EVSSDGTTPLAIAKRL 777



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 40/139 (28%), Positives = 71/139 (51%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T+  RA   G+L      +  G  I   +      +H AS+ G++ ++  LL+K   +  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K  +TALH+A   G  E    L+   A++NA+ ++G TPL+ A + N  ++++ L+  
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 275 GADLNIKNCAGKTPMDLVL 293
           GA+ N+    G TP+ + L
Sbjct: 134 GANQNVATEDGFTPLAVAL 152



 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 47/165 (28%), Positives = 76/165 (46%), Gaps = 4/165 (2%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL  +  VV + ++   N +   +   T L+ A  E HL +V+ L+E GA         
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +  A + G+ +V+  L+N G K     K+   ALH+A R      A  L+  + + +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPD 200

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
              + G TPLH A       + +LL+  GA +N     G TP+ +
Sbjct: 201 VLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 34/111 (30%), Positives = 59/111 (53%)

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + FR+   +T+   A+R GNLD     L  G  I+  ++     LH+A + GH +    L
Sbjct: 5   VGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 64

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           +  E  L    ++G+T LH A    + +++R L+ YGA++N ++  G TP+
Sbjct: 65  LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 115



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 29/111 (26%), Positives = 52/111 (46%)

Query: 128 ALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLES 187
           A E  +PV +  +      D       T LH A   G++ +V+ L++  A +  +  L  
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 188 TAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           + +H A++ G+ D++ LLL  GA  +      +T L +A R G+    + L
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score = 96.7 bits (239), Expect = 2e-20
 Identities = 56/155 (36%), Positives = 84/155 (54%)

Query: 137 EKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRG 196
           E  L+DK+     D+  RTALH AC  GH  IVE L++ G  +  +D    + +H A+  
Sbjct: 24  ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83

Query: 197 GNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPL 256
           G  +++K LL KGA+++A ++   T LH A     +E A  L+   A+ +AKD    T +
Sbjct: 84  GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143

Query: 257 HDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           H A      KMI +L+ Y A  NI++  G TP+ L
Sbjct: 144 HRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178



 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 33/100 (33%), Positives = 52/100 (52%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N+  +    L    NPD  D Y+ TA+HRA  +G+L ++  L+   A    +D   
Sbjct: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVA 226
           +T +H A     ++  KLL+++GA I   +K   T L VA
Sbjct: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212



 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 39/133 (29%), Positives = 66/133 (49%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA   +  +V+  L      +  ++   T LH A  +    I   L+E GA  + +D  E
Sbjct: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
           +TA+H A+  GNL ++ +LL   A  + +D   +T LH+A      E A+ L++  A + 
Sbjct: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199

Query: 247 AKDREGDTPLHDA 259
            +++E  TPL  A
Sbjct: 200 IENKEEKTPLQVA 212



 Score = 31.6 bits (70), Expect = 0.98
 Identities = 21/80 (26%), Positives = 37/80 (46%)

Query: 126 KAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDML 185
           +AA +  L ++   L  K + ++ D    T LH AC E  +   + L+  GA I   +  
Sbjct: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204

Query: 186 ESTAIHWASRGGNLDVLKLL 205
           E T +  A  G  L + +++
Sbjct: 205 EKTPLQVAKGGLGLILKRMV 224


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
           isoform 1 [Homo sapiens]
          Length = 1298

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 77/266 (28%), Positives = 118/266 (44%), Gaps = 51/266 (19%)

Query: 75  LEQRSKLENLEDLEIIIQLKKRKKYR----------------KTKVPVVKEPEPEIITEP 118
           L Q    E LE   I +  +K KK R                K  + +V   +P    E 
Sbjct: 711 LSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEH 770

Query: 119 VDVPTFLKAALE-NKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGA 177
            +  + L AA E   + +    +    N D C E +RT L  A    HL  V+ L++AGA
Sbjct: 771 QNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGA 830

Query: 178 QIEFRDMLESTAIH----------------------------------WASRGGNLDVLK 203
            ++ +D   ST +H                                  WA+   ++D++K
Sbjct: 831 LVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVK 890

Query: 204 LLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLN 263
           LLL+KG+ I+ RD   +  LH A  +G  + AE L+A + DL+A +  GD+PLH A R N
Sbjct: 891 LLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAAREN 950

Query: 264 RYKMIRLLIMYGADLNIKNCAGKTPM 289
           RY  + L +   +D+ +KN  G+TP+
Sbjct: 951 RYDCVVLFLSRDSDVTLKNKEGETPL 976



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 54/172 (31%), Positives = 94/172 (54%), Gaps = 7/172 (4%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEY--KRTALHRACLEGHLAIVEKLMEAGAQIEFRDM 184
           +A + +L  V   L D  +P+   E+  KR+ LH A   GH+ I   L++AGA I+    
Sbjct: 745 SARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSE 804

Query: 185 LESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIA-CEA 243
            + T +  A+   +L+ +K L+  GA +  +D   ST LH+A + GHYE  ++L++  + 
Sbjct: 805 DQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQM 864

Query: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295
           D+N +D  G TP+  A       +++LL+  G+D+NI++       ++ LHW
Sbjct: 865 DVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRD----NEENICLHW 912



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 40/134 (29%), Positives = 70/134 (52%), Gaps = 1/134 (0%)

Query: 127 AALENKLPVVEKFLSDKNNPDVC-DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDML 185
           AA +    VV+  LS+      C D+   T +  A    H+ +V+ L+  G+ I  RD  
Sbjct: 846 AAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNE 905

Query: 186 ESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADL 245
           E+  +HWA+  G +D+ ++LL     + A +    + LH+A R   Y+C    ++ ++D+
Sbjct: 906 ENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDV 965

Query: 246 NAKDREGDTPLHDA 259
             K++EG+TPL  A
Sbjct: 966 TLKNKEGETPLQCA 979


>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
          Length = 722

 Score = 95.5 bits (236), Expect = 6e-20
 Identities = 59/163 (36%), Positives = 90/163 (55%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +  LPVV+  L    + DV D+  +TALHRA + G+  I+  L+  G  ++ +D   
Sbjct: 49  AANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCALDRQDKDG 108

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
           +TA+H AS  G     KLL+  GA + A++K  +TALH+A +  H +    L+   +  +
Sbjct: 109 NTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRAD 168

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
            K+  GDT LH A R N   +IRLL+     ++ KN AG T +
Sbjct: 169 LKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTAL 211



 Score = 88.2 bits (217), Expect = 9e-18
 Identities = 47/147 (31%), Positives = 90/147 (61%)

Query: 151 EYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGA 210
           ++ RT LH A  +GHL +V+ L++AG  ++ +D  + TA+H A+  GN +++  L+++G 
Sbjct: 40  KHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGC 99

Query: 211 KISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRL 270
            +  +DK  +TALH A   G  + A+ L+   A++ AK++ G+T LH A + +  +  R+
Sbjct: 100 ALDRQDKDGNTALHEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRV 159

Query: 271 LIMYGADLNIKNCAGKTPMDLVLHWQN 297
           L++ G+  ++KN AG T + +   + +
Sbjct: 160 LLLAGSRADLKNNAGDTCLHVAARYNH 186



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 37/117 (31%), Positives = 59/117 (50%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           TALH AC   H      L+ AG++ + ++    T +H A+R  +L +++LLL     +  
Sbjct: 143 TALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHE 202

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLL 271
           +++   TALHVA    H + A+ L+   AD    +  G TPL  A   N  ++  LL
Sbjct: 203 KNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNPEVALLL 259



 Score = 31.6 bits (70), Expect = 0.98
 Identities = 22/71 (30%), Positives = 35/71 (49%), Gaps = 1/71 (1%)

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
           LS  L VA   G  E    LI   A + A  + G TPLH A       ++++L+  G DL
Sbjct: 10  LSERLLVAAYKGQTENVVQLINKGARV-AVTKHGRTPLHLAANKGHLPVVQILLKAGCDL 68

Query: 279 NIKNCAGKTPM 289
           ++++   +T +
Sbjct: 69  DVQDDGDQTAL 79


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 62/206 (30%), Positives = 108/206 (52%), Gaps = 8/206 (3%)

Query: 100 RKTKVPV---VKEPEPEIITEPVDV---PTFLKAALENKLPVVEKFLSDKNNPDVCDEYK 153
           +K  VPV   + E   ++  + VD      F +AA   +L  ++  +    + +V D+  
Sbjct: 133 QKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEG 192

Query: 154 RTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKIS 213
            TALH A   GH+A++++L++ G  +E ++    TA+H A+ G + D ++LLL  G+ ++
Sbjct: 193 NTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVN 252

Query: 214 ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM 273
           A  +   + LH A  +G  + +  LI      N  D +G +PLH AVR N   ++RLLI 
Sbjct: 253 ALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLIN 312

Query: 274 YGADLNIKNCAGKTPMDLVLH--WQN 297
             +D+N  +   +TP+ L     WQ+
Sbjct: 313 SDSDVNAVDNRQQTPLHLAAEHAWQD 338



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 56/209 (26%), Positives = 85/209 (40%), Gaps = 45/209 (21%)

Query: 126 KAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLME----------A 175
           +AA +N +  +++ +  + N    +   R ALH A   GH   V  L+E           
Sbjct: 21  EAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAV 80

Query: 176 GAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGH---- 231
           GA  E R      A+  ++  G+L +L++L+N GAKI    K   T LH A + GH    
Sbjct: 81  GALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVL 140

Query: 232 -----------------------YECAEH--------LIACEADLNAKDREGDTPLHDAV 260
                                  +  AEH        L+    D N KD+EG+T LH A 
Sbjct: 141 AFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAA 200

Query: 261 RLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
                 +++ L+  G DL  +N  G T +
Sbjct: 201 GRGHMAVLQRLVDIGLDLEEQNAEGLTAL 229



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 35/118 (29%), Positives = 59/118 (50%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           + LH A L G   +   L+ AG      D   ++ +H A R     +++LL+N  + ++A
Sbjct: 260 SCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNA 319

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLI 272
            D    T LH+A      + A+ L+    DLN +D++G T L  AVR N   ++ ++I
Sbjct: 320 VDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 32/116 (27%), Positives = 51/116 (43%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL     V    +      +V D    + LH A      A+V  L+ + + +   D  +
Sbjct: 265 AALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQ 324

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
            T +H A+     D+  +LL  G  ++ RDK   TAL VAVR+ H    + +I  +
Sbjct: 325 QTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKAD 380



 Score = 32.7 bits (73), Expect = 0.44
 Identities = 18/63 (28%), Positives = 32/63 (50%)

Query: 190 IHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKD 249
           +H A+R  N+  ++ L+ +     AR+ +   ALH A   GH +    L+  EA ++ +D
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 250 REG 252
             G
Sbjct: 79  AVG 81


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 89.0 bits (219), Expect = 5e-18
 Identities = 51/176 (28%), Positives = 90/176 (51%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA    + +V + +    +P+  +    TALH A   G   +V  L++ GAQ+E +   +
Sbjct: 440 AAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDD 499

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H ++R G  D+++ LL +GA  +A      T LH++ R GH + A  L+   A L+
Sbjct: 500 QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS 559

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAI 302
              ++G TPLH A +  + ++  LL+   A  +    +G TP+ +  H+ N   A+
Sbjct: 560 ITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVAL 615



 Score = 88.2 bits (217), Expect = 9e-18
 Identities = 58/191 (30%), Positives = 92/191 (48%), Gaps = 1/191 (0%)

Query: 99  YRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALH 158
           Y+  KV + K+  P         P  + A  +N++ V+E  L    +     E   T +H
Sbjct: 380 YKVAKVLLDKKANPNAKALNGFTPLHI-ACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
            A   GH+ IV +LM  GA     ++   TA+H A+R G  +V++ L+  GA++ A+ K 
Sbjct: 439 VAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD 498

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
             T LH++ R G  +  + L+   A  NA    G TPLH + R     +   L+ +GA L
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASL 558

Query: 279 NIKNCAGKTPM 289
           +I    G TP+
Sbjct: 559 SITTKKGFTPL 569



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 48/135 (35%), Positives = 74/135 (54%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH     GH  +VE L++  A I  +     + +H A++G +L+ ++LLL     +  
Sbjct: 303 TPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD 362

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
                 TALHVA   GHY+ A+ L+  +A+ NAK   G TPLH A + NR K++ LL+ +
Sbjct: 363 VTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKH 422

Query: 275 GADLNIKNCAGKTPM 289
           GA +     +G TP+
Sbjct: 423 GASIQAVTESGLTPI 437



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 49/157 (31%), Positives = 83/157 (52%)

Query: 135 VVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWAS 194
           V +  L  K NP+       T LH AC +  + ++E L++ GA I+       T IH A+
Sbjct: 382 VAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAA 441

Query: 195 RGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDT 254
             G+++++  L++ GA  +  +    TALH+A R+G  E   +L+   A + AK ++  T
Sbjct: 442 FMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQT 501

Query: 255 PLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           PLH + RL +  +++ L+  GA  N    +G TP+ L
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHL 538



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 49/161 (30%), Positives = 85/161 (52%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           V +P    AA ++        L + NN DV  +   T LH A   G++ +   L+   A 
Sbjct: 201 VRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAA 260

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           ++F    + T +H AS+ GN +++KLLL++GAKI A+ +   T LH   R+GH +  E L
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
           +   A + +K + G +PLH A + +    ++LL+ +   ++
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD 361



 Score = 78.6 bits (192), Expect = 7e-15
 Identities = 60/250 (24%), Positives = 115/250 (46%), Gaps = 39/250 (15%)

Query: 79  SKLENLEDLEIIIQLK--KRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVV 136
           S+L+   DLEI  + +  K++K+RK      K+ +           ++L+AA    L   
Sbjct: 6   SQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANA--------SYLRAARAGHLEKA 57

Query: 137 EKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRG 196
             ++ +  + ++C++    ALH A  EGH+ +V +L++  A ++      +TA+H AS  
Sbjct: 58  LDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLA 117

Query: 197 GNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTP- 255
           G  +V+K+L+  GA ++A+ +   T L++A +  H E  + L+   A  +    +G TP 
Sbjct: 118 GQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL 177

Query: 256 ----------------------------LHDAVRLNRYKMIRLLIMYGADLNIKNCAGKT 287
                                       LH A R +  K   LL+    + ++++ +G T
Sbjct: 178 AVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFT 237

Query: 288 PMDLVLHWQN 297
           P+ +  H+ N
Sbjct: 238 PLHIAAHYGN 247



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 49/192 (25%), Positives = 92/192 (47%), Gaps = 2/192 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ +    L    + +        ++H A  EGH+ +V  L+   A +   +   
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++   ++V ++L+N+GA + A+ K+  T LHV    G+ +    L+   A +N
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           AK + G TPLH A +     +I +L+   A  N     G T + +    + G  ++ D+L
Sbjct: 758 AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR--RLGYISVVDTL 815

Query: 307 RENSYKTSRIAT 318
           +  + +T    T
Sbjct: 816 KIVTEETMTTTT 827



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 51/158 (32%), Positives = 75/158 (47%), Gaps = 1/158 (0%)

Query: 122 PTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEF 181
           P  + A L  K  +V++ L    +P+       T LH +  EGH  +   L++ GA +  
Sbjct: 502 PLHISARL-GKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560

Query: 182 RDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIAC 241
                 T +H A++ G L+V  LLL K A   A  K   T LHVA    + + A  L+  
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620

Query: 242 EADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
            A  +A  + G TPLH A + N+  +   L+ YGAD N
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN 658



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 48/154 (31%), Positives = 79/154 (51%), Gaps = 2/154 (1%)

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
           RA   GHL      ++ G  I   +     A+H AS+ G+++V+  LL + A + A  K 
Sbjct: 47  RAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKK 106

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
            +TALH+A   G  E  + L+   A++NA+ + G TPL+ A + N  ++++ L+  GA  
Sbjct: 107 GNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQ 166

Query: 279 NIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYK 312
           ++    G TP+ + L  Q G   +   L EN  K
Sbjct: 167 SLATEDGFTPLAVAL--QQGHDQVVSLLLENDTK 198



 Score = 73.2 bits (178), Expect = 3e-13
 Identities = 57/216 (26%), Positives = 97/216 (44%), Gaps = 6/216 (2%)

Query: 98  KYRKTKVP---VVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKR 154
           KY K +V    + K   P+   +    P  + A  +N+  V    L    +P    +   
Sbjct: 574 KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQ-KVALLLLDQGASPHAAAKNGY 632

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH A  +  + I   L+E GA           ++H A++ G++D++ LLL + A ++ 
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
            +K   T LH+A +      AE L+   A ++A+ + G TPLH        K++  L+ +
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752

Query: 275 GADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENS 310
            A +N K   G TP+      Q G   I + L +N+
Sbjct: 753 SAKVNAKTKNGYTPLHQAA--QQGHTHIINVLLQNN 786



 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 51/165 (30%), Positives = 77/165 (46%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA   +  VV   + D    +   +  +T LH +   G   IV++L++ GA         
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H ++R G+ DV   LL+ GA +S   K   T LHVA + G  E A  L+   A  +
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           A  + G TPLH A   +  K+  LL+  GA  +     G TP+ +
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHI 637



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 45/145 (31%), Positives = 72/145 (49%), Gaps = 1/145 (0%)

Query: 147 DVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLL 206
           DV ++Y  TALH A   GH  + + L++  A    + +   T +H A +   + V++LLL
Sbjct: 362 DVTNDYL-TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL 420

Query: 207 NKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYK 266
             GA I A  +   T +HVA   GH      L+   A  N  +  G+T LH A R  + +
Sbjct: 421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480

Query: 267 MIRLLIMYGADLNIKNCAGKTPMDL 291
           ++R L+  GA +  K    +TP+ +
Sbjct: 481 VVRYLVQDGAQVEAKAKDDQTPLHI 505



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 55/194 (28%), Positives = 87/194 (44%), Gaps = 29/194 (14%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLME------------ 174
           AA EN L VV+  L +  +  +  E   T L  A  +GH  +V  L+E            
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPAL 206

Query: 175 ----------AGAQIEFRDM---LES----TAIHWASRGGNLDVLKLLLNKGAKISARDK 217
                     A A +   D    +ES    T +H A+  GN++V  LLLN+ A +    +
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266

Query: 218 LLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGAD 277
              T LHVA + G+    + L+   A ++AK R+G TPLH   R    +++ +L+   A 
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326

Query: 278 LNIKNCAGKTPMDL 291
           +  K   G +P+ +
Sbjct: 327 ILSKTKNGLSPLHM 340


>gi|148596917 fibronectin type III and ankyrin repeat domains 1
           [Homo sapiens]
          Length = 345

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 56/181 (30%), Positives = 98/181 (54%), Gaps = 8/181 (4%)

Query: 119 VDVPT------FLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKL 172
           VDVP        + AA +    +V+  +S+  + ++ +   + +L  AC  GHL +V+ L
Sbjct: 137 VDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYL 196

Query: 173 MEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARD--KLLSTALHVAVRTG 230
              GA  + RD+   TA+HWA+ GG+  V++ ++  G ++   D     +  + V+  +G
Sbjct: 197 RRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVDTGSGWTPLMRVSAVSG 256

Query: 231 HYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMD 290
           +   A  LI   A++N KDR G TPL  AV  N  ++++LL+  GAD ++KN  GK  ++
Sbjct: 257 NQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDKGADASVKNEFGKGVLE 316

Query: 291 L 291
           +
Sbjct: 317 M 317



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 31/135 (22%), Positives = 68/135 (50%), Gaps = 2/135 (1%)

Query: 157 LHRACLEGHLAIVEKLMEAG-AQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISAR 215
           LHRA       ++ ++++ G  +++  +    TA+  A++ G   ++K+L++ G  ++ +
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173

Query: 216 DKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYG 275
           +     +L +A   GH +  ++L    A   A+D  G T LH A       +I  +I  G
Sbjct: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDG 233

Query: 276 ADLNIKNC-AGKTPM 289
            ++++ +  +G TP+
Sbjct: 234 CEVDVVDTGSGWTPL 248



 Score = 32.0 bits (71), Expect = 0.75
 Identities = 19/83 (22%), Positives = 41/83 (49%), Gaps = 1/83 (1%)

Query: 213 SARDKLLSTALHVAVRTGHYECAEHLI-ACEADLNAKDREGDTPLHDAVRLNRYKMIRLL 271
           + R+ + S  LH AV     +    ++      ++  ++ G T L  A +    +++++L
Sbjct: 104 TTREPISSEHLHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKIL 163

Query: 272 IMYGADLNIKNCAGKTPMDLVLH 294
           +  G D+N+KN +GK  + L  +
Sbjct: 164 VSNGTDVNLKNGSGKDSLMLACY 186


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 54/169 (31%), Positives = 82/169 (48%), Gaps = 2/169 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL   +  V+  L +    D  D  K T L RAC  GH  +++ L++ GA+++  D   
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            + +HWA+ GGN DV ++L+      + +D    T L  A   G+  C   L+   AD N
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN--IKNCAGKTPMDLVL 293
            +D+EG T LH +        I+LL+ + A  N    N    TP+D  L
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 59/202 (29%), Positives = 104/202 (51%), Gaps = 6/202 (2%)

Query: 96  RKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDV--CDEYK 153
           +  + +T    +K P  +  ++     +F+ AA +    V+   LS K++ D+   D+Y 
Sbjct: 298 QSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYG 357

Query: 154 RTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKIS 213
            TALH A L GH++ V+ L+E  AQ++  D+++ T +  A   G+ DV++ L+  GA++ 
Sbjct: 358 GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD 417

Query: 214 ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM 273
             D+   + LH A   G+ +  + LI  + + N +D  G TPL  A        + +L+ 
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477

Query: 274 YGADLNIKNCAGKTPMDLVLHW 295
             AD NI++  G+T     LHW
Sbjct: 478 NNADPNIQDKEGRT----ALHW 495



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 53/172 (30%), Positives = 85/172 (49%), Gaps = 12/172 (6%)

Query: 126 KAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDML 185
           K AL+ +L V    L DK      D++ RT L    L   L   + L++AGA +   D  
Sbjct: 27  KGALQ-RLIVGNSALKDKE-----DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 186 ESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA-- 243
           + TA+H A++ GN   +KLLL + A    +D    T LH+  R    +C   L+   A  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295
           +++ +D+   T LH +   N  + ++LLI + +++ I +  GK P    LHW
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP----LHW 188



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 49/172 (28%), Positives = 77/172 (44%), Gaps = 7/172 (4%)

Query: 127 AALENKLPVVEKFLS-DKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDML 185
           AAL     +V   L  +K+     D    T LH A        V+  ++  +  +  D+ 
Sbjct: 262 AALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE 321

Query: 186 ESTAIHWASRGGNLDVLK--LLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
             T+  WA+  G+ DVL+  L L     I+  DK   TALH A  +GH    + L+   A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381

Query: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295
            ++A D    TPL  A  +    +I+ LI  GA +++ +  G +    +LHW
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS----LLHW 429



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 16/139 (11%)

Query: 166 LAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHV 225
           LA++ K M  G +++ +D  + TA+HW++   N + +KLL+   + I   D      LH 
Sbjct: 130 LALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHW 188

Query: 226 AVRTGHYE-CAEHLIAC-------EADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY-GA 276
           A    H +  A H + C       E+ LN +D EG TPLH AV      ++ +L  Y   
Sbjct: 189 A--ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 246

Query: 277 DLNIKNCAGKTPMDLVLHW 295
           ++   +   +TP    LHW
Sbjct: 247 NITSYDNLFRTP----LHW 261



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 40/165 (24%), Positives = 78/165 (47%), Gaps = 15/165 (9%)

Query: 133 LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHW 192
           L ++ KF++     D  D+ K+TALH +    +   V+ L++  + I   D+     +HW
Sbjct: 130 LALLLKFMAP-GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHW 188

Query: 193 ASRGGN---LDVLKLLLNKG---AKISARDKLLSTALHVAVRTGHYECAEHLIACEA-DL 245
           A+   +   +  ++ +L+     + ++ +D    T LH AV  G+    + L + E+ ++
Sbjct: 189 AANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNI 248

Query: 246 NAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMD 290
            + D    TPLH A  L   +++ LL+        +N +G  P D
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLE-------RNKSGTIPSD 286


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 54/169 (31%), Positives = 82/169 (48%), Gaps = 2/169 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AAL   +  V+  L +    D  D  K T L RAC  GH  +++ L++ GA+++  D   
Sbjct: 364 AALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            + +HWA+ GGN DV ++L+      + +D    T L  A   G+  C   L+   AD N
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN--IKNCAGKTPMDLVL 293
            +D+EG T LH +        I+LL+ + A  N    N    TP+D  L
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532



 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 59/202 (29%), Positives = 104/202 (51%), Gaps = 6/202 (2%)

Query: 96  RKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDV--CDEYK 153
           +  + +T    +K P  +  ++     +F+ AA +    V+   LS K++ D+   D+Y 
Sbjct: 298 QSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYG 357

Query: 154 RTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKIS 213
            TALH A L GH++ V+ L+E  AQ++  D+++ T +  A   G+ DV++ L+  GA++ 
Sbjct: 358 GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVD 417

Query: 214 ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM 273
             D+   + LH A   G+ +  + LI  + + N +D  G TPL  A        + +L+ 
Sbjct: 418 LVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLME 477

Query: 274 YGADLNIKNCAGKTPMDLVLHW 295
             AD NI++  G+T     LHW
Sbjct: 478 NNADPNIQDKEGRT----ALHW 495



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 53/172 (30%), Positives = 85/172 (49%), Gaps = 12/172 (6%)

Query: 126 KAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDML 185
           K AL+ +L V    L DK      D++ RT L    L   L   + L++AGA +   D  
Sbjct: 27  KGALQ-RLIVGNSALKDKE-----DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHS 80

Query: 186 ESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA-- 243
           + TA+H A++ GN   +KLLL + A    +D    T LH+  R    +C   L+   A  
Sbjct: 81  QRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPG 140

Query: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295
           +++ +D+   T LH +   N  + ++LLI + +++ I +  GK P    LHW
Sbjct: 141 EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIP----LHW 188



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 49/172 (28%), Positives = 77/172 (44%), Gaps = 7/172 (4%)

Query: 127 AALENKLPVVEKFLS-DKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDML 185
           AAL     +V   L  +K+     D    T LH A        V+  ++  +  +  D+ 
Sbjct: 262 AALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLE 321

Query: 186 ESTAIHWASRGGNLDVLK--LLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
             T+  WA+  G+ DVL+  L L     I+  DK   TALH A  +GH    + L+   A
Sbjct: 322 GRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNA 381

Query: 244 DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHW 295
            ++A D    TPL  A  +    +I+ LI  GA +++ +  G +    +LHW
Sbjct: 382 QVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHS----LLHW 429



 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 16/139 (11%)

Query: 166 LAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHV 225
           LA++ K M  G +++ +D  + TA+HW++   N + +KLL+   + I   D      LH 
Sbjct: 130 LALLLKFMAPG-EVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHW 188

Query: 226 AVRTGHYE-CAEHLIAC-------EADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY-GA 276
           A    H +  A H + C       E+ LN +D EG TPLH AV      ++ +L  Y   
Sbjct: 189 A--ANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESC 246

Query: 277 DLNIKNCAGKTPMDLVLHW 295
           ++   +   +TP    LHW
Sbjct: 247 NITSYDNLFRTP----LHW 261



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 40/165 (24%), Positives = 78/165 (47%), Gaps = 15/165 (9%)

Query: 133 LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHW 192
           L ++ KF++     D  D+ K+TALH +    +   V+ L++  + I   D+     +HW
Sbjct: 130 LALLLKFMAP-GEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHW 188

Query: 193 ASRGGN---LDVLKLLLNKG---AKISARDKLLSTALHVAVRTGHYECAEHLIACEA-DL 245
           A+   +   +  ++ +L+     + ++ +D    T LH AV  G+    + L + E+ ++
Sbjct: 189 AANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNI 248

Query: 246 NAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMD 290
            + D    TPLH A  L   +++ LL+        +N +G  P D
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLE-------RNKSGTIPSD 286


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 53/163 (32%), Positives = 89/163 (54%), Gaps = 1/163 (0%)

Query: 122  PTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEF 181
            PT    ALEN+L + E FL +  N +  D   RTALH +C +GH+ +V+ L+   A +  
Sbjct: 948  PTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007

Query: 182  RDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIAC 241
             D  + +A+  A+  G++ V++LL+  GA +       +TAL +A + GH +  + L+  
Sbjct: 1008 ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEH 1067

Query: 242  EADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCA 284
             AD N  D+ G T +  A +    ++I+LL  YGA  ++  C+
Sbjct: 1068 GADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS-SLNGCS 1109



 Score = 82.0 bits (201), Expect = 6e-16
 Identities = 54/153 (35%), Positives = 75/153 (49%)

Query: 124  FLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD 183
            F+ A+ E     V+  L +K+N D      R AL  A LEGH  IVE L   GA +  +D
Sbjct: 884  FILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKD 943

Query: 184  MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
                  ++  +    L + +  L  GA + A D    TALHV+   GH E  + LIA  A
Sbjct: 944  ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHA 1003

Query: 244  DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGA 276
            D+NA D E  + L  A      K+++LLI +GA
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGA 1036



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 50/165 (30%), Positives = 82/165 (49%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA    L VV   +S   + ++ D +  T L  A  +GH  +V  L+  GA I   D   
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            TA+  A+ GG+ +V+  LL  G K+   D    TAL  A   GH +   +L+   A++N
Sbjct: 612 WTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
             D EG T L  A  +   +++  L+ +GA++N ++  G+T + +
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716



 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 49/165 (29%), Positives = 79/165 (47%)

Query: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDM 184
           L AA E  + VV+  L    + D  D   RT L  A   GH ++V  L+  GA ++  D 
Sbjct: 753 LVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS 812

Query: 185 LESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD 244
              T +  AS  GN++V++ LL++G   + RD    T LH+A   GH    E LI   A 
Sbjct: 813 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
            N  D +G  P   A +   Y  +++L+   ++++ +   G+  +
Sbjct: 873 TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNAL 917



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 61/203 (30%), Positives = 85/203 (41%), Gaps = 8/203 (3%)

Query: 113 EIITEPVDVPTFLKAAL------ENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHL 166
           E+  E VD  T L  A       +    VV   +      D CD+   T L  A  EGH+
Sbjct: 702 EVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHV 761

Query: 167 AIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVA 226
            +V+ L+E GA ++  D    T +  A+  G+  V+  LL  GA + + D    T L +A
Sbjct: 762 DVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIA 821

Query: 227 VRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGK 286
              G+ E    L+    D N +D  G TPLH A       +   LI  GA  N  +  G+
Sbjct: 822 SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGR 881

Query: 287 TPMDLVLHWQNGTKAIFDSLREN 309
            P   +L  Q G       L EN
Sbjct: 882 IP--FILASQEGHYDCVQILLEN 902



 Score = 65.1 bits (157), Expect = 8e-11
 Identities = 53/168 (31%), Positives = 81/168 (48%), Gaps = 5/168 (2%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA      VV   L      D  D   RTAL  A   GH  IV  L++ GA++   D   
Sbjct: 618 AAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEG 677

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVA-----VRTGHYECAEHLIAC 241
            TA+  A+  G+ ++++ LL+ GA+++  D    TAL VA        GH      LI  
Sbjct: 678 RTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDR 737

Query: 242 EADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
            A+++  D++G TPL  A       ++ LL+  GAD++  +  G+TP+
Sbjct: 738 GAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPL 785



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 45/176 (25%), Positives = 79/176 (44%), Gaps = 1/176 (0%)

Query: 127  AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
            AA E    + E  +      +  D   R     A  EGH   V+ L+E  + I+ R    
Sbjct: 854  AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDG 913

Query: 187  STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
              A+  A+  G+ D+++LL + GA ++ +D      L++         AE+ +   A++ 
Sbjct: 914  RNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVE 973

Query: 247  AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAI 302
            A D EG T LH +      +M+++LI Y AD+N  +   ++ +     WQ   K +
Sbjct: 974  ASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA-WQGHVKVV 1028



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 46/165 (27%), Positives = 76/165 (46%), Gaps = 1/165 (0%)

Query: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDM 184
           ++ ALE +   +   L +  + + CD   RT L  A   G L +V  L+  GA +E  D 
Sbjct: 518 VRQALERE-DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDA 576

Query: 185 LESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD 244
              T +  A+R G+  V+  L+  GA I+  D+   TAL  A   GH E    L+     
Sbjct: 577 HGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVK 636

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
           ++  D +  T L  A       ++  L+ +GA++N  +  G+T +
Sbjct: 637 VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 3/103 (2%)

Query: 200 DVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDA 259
           +VL+LL+  GA +++ D   S  +  A+     +    L+   A +N  D  G T L +A
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALE--REDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 260 VRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAI 302
                  ++ LL+  GADL I++  G TP+ L    Q  TK +
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR-QGHTKVV 594


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score = 85.9 bits (211), Expect = 4e-17
 Identities = 48/158 (30%), Positives = 84/158 (53%)

Query: 136 VEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASR 195
           V++ L    N ++ D+   TAL  A  EGH  IV+ L++AG  +   D    T +  A R
Sbjct: 219 VKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVR 278

Query: 196 GGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTP 255
           GG++++++ LL K A I  R +   TAL+ AV  G+      ++ C  D     ++G+TP
Sbjct: 279 GGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETP 338

Query: 256 LHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVL 293
           L  A ++   +++ LL+  GA ++  +  G TP+ + +
Sbjct: 339 LIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAI 376



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 62/218 (28%), Positives = 104/218 (47%), Gaps = 34/218 (15%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +  L +V++ + +  N ++ D    TAL  A  EGH+ IVE+L++ G  +E RDM  
Sbjct: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104

Query: 187 STAIHWA-------------SRG--------------------GNLDVLKLLLNKGAKIS 213
            TA+ WA             S G                    G+ D++ LLL  GAK++
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVN 164

Query: 214 ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM 273
             DK  +T L  A R GH EC +HL+A  AD++ +     T L  AV+    + ++ ++ 
Sbjct: 165 CSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK 224

Query: 274 YGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSY 311
              ++N+ +  G T + ++   +  T+ + D L   +Y
Sbjct: 225 RNPNVNLTDKDGNTAL-MIASKEGHTEIVQDLLDAGTY 261



 Score = 78.6 bits (192), Expect = 7e-15
 Identities = 54/185 (29%), Positives = 87/185 (47%)

Query: 115 ITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLME 174
           +T    V   + AA      +V   L +    +  D+Y  T L  A  +GHL  V+ L+ 
Sbjct: 132 VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191

Query: 175 AGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYEC 234
            GA ++       TA+  A +GG    +K +L +   ++  DK  +TAL +A + GH E 
Sbjct: 192 MGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEI 251

Query: 235 AEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLH 294
            + L+     +N  DR GDT L  AVR    +++R L+   AD++I+    KT +   + 
Sbjct: 252 VQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVE 311

Query: 295 WQNGT 299
             N T
Sbjct: 312 KGNAT 316



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 49/161 (30%), Positives = 83/161 (51%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           A  + +  VVE  LS   NP V   Y    +  A   GH  IV  L++ GA++   D   
Sbjct: 111 ACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYG 170

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
           +T + WA+R G+L+ +K LL  GA +        TAL VAV+ G+ +  + ++    ++N
Sbjct: 171 TTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVN 230

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKT 287
             D++G+T L  A +    ++++ L+  G  +NI + +G T
Sbjct: 231 LTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDT 271



 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 44/163 (26%), Positives = 79/163 (48%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +  L  V+  L+   + D       TAL  A   G+   V+++++    +   D   
Sbjct: 177 AARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG 236

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
           +TA+  AS+ G+ ++++ LL+ G  ++  D+   T L  AVR GH E    L+   AD++
Sbjct: 237 NTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADID 296

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
            + ++  T L+ AV      M+R ++    D  I    G+TP+
Sbjct: 297 IRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339


>gi|118150656 ankyrin repeat domain 7 [Homo sapiens]
          Length = 254

 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 65/209 (31%), Positives = 102/209 (48%), Gaps = 11/209 (5%)

Query: 120 DVPTFLKAALENKLPVVEKFLSDKN-NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQ 178
           D+    +AA    L  ++++L  K  + ++ D+  RT LH AC  GH  +V  L+E   +
Sbjct: 25  DLKKLHRAASVGDLKKLKEYLQIKKYDVNMQDKKYRTPLHLACANGHTDVVLFLIEQQCK 84

Query: 179 IEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHL 238
           I  RD    + +  A +  N D   +LLN GA    RD   +T LH AV        E L
Sbjct: 85  INVRDSENKSPLIKAVQCQNEDCATILLNFGADPDLRDIRYNTVLHYAVCGQSLSLVEKL 144

Query: 239 IACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN----------IKNCAGKTP 288
           +  EADL AK+++G TPL  AV  N  KM++ L+  GAD+N          I   +G+ P
Sbjct: 145 LEYEADLEAKNKDGYTPLLVAVINNNPKMVKFLLEKGADVNASDNYQRTALILAVSGEPP 204

Query: 289 MDLVLHWQNGTKAIFDSLRENSYKTSRIA 317
             + L  Q G +  ++ + ++  +   I+
Sbjct: 205 CLVKLLLQQGVELCYEGIVDSQLRNMFIS 233


>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
           [Homo sapiens]
          Length = 1849

 Score = 85.1 bits (209), Expect = 7e-17
 Identities = 75/282 (26%), Positives = 131/282 (46%), Gaps = 23/282 (8%)

Query: 17  NGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLE 76
           NG  G+FL E+    EY   V     E + +L        E ++K    ++A L +K+L 
Sbjct: 109 NGRDGKFLDEERLLREYPQPVG----EGVPSL--------EFRYKKRVYKQASLDEKQLA 156

Query: 77  QRSKLENLEDLEIIIQLKKRKKYRKTKV----PVVKEPEPEIITEPVDVPTFLKAALENK 132
           +     NL+     IQ +  +K  K       P   +PE        + P  L A L++ 
Sbjct: 157 KLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETG------ETPLTLAAQLDDS 210

Query: 133 LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI-H 191
           + V++   +   + D   +   TALH+A    +   ++ L+E GA  +++D    T + H
Sbjct: 211 VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270

Query: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
            A  GG+    +LLL++ A +  +D+     +H A R GH +  EHL+   AD++A++  
Sbjct: 271 TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNAS 330

Query: 252 GDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVL 293
           G+T LH     N+    R+L+  G +  +KN   +TP  + +
Sbjct: 331 GNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVAI 372



 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 24/89 (26%), Positives = 45/89 (50%)

Query: 150 DEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
           DE     +H+AC  GH+  +E L+  GA +  ++   +TA+H  +        ++LL +G
Sbjct: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354

Query: 210 AKISARDKLLSTALHVAVRTGHYECAEHL 238
                ++    T   VA+  G++E AE++
Sbjct: 355 GNKELKNYNSQTPFQVAIIAGNFELAEYI 383


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 50/135 (37%), Positives = 73/135 (54%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH A   GH  +VE L+E GA +  R     + +H A++G +++ +K LL   A +  
Sbjct: 280 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 339

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
                 TALHVA   GHY   + L+   A+ NA+   G TPLH A + NR K++ LL+ Y
Sbjct: 340 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 399

Query: 275 GADLNIKNCAGKTPM 289
           GA +     +G TP+
Sbjct: 400 GASIQAITESGLTPI 414



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 58/191 (30%), Positives = 93/191 (48%), Gaps = 1/191 (0%)

Query: 99  YRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALH 158
           YR TK+ + K   P         P  + A  +N++ V+E  +    +     E   T +H
Sbjct: 357 YRVTKLLLDKRANPNARALNGFTPLHI-ACKKNRIKVMELLVKYGASIQAITESGLTPIH 415

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
            A   GHL IV  L++ GA  +  ++   TA+H A+R G ++V++ LL  GA + AR + 
Sbjct: 416 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE 475

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
             T LH+A R G  E  + L+   A  +A    G TPLH + R  +  +  +L+  GA  
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 535

Query: 279 NIKNCAGKTPM 289
           ++    G TP+
Sbjct: 536 SLATKKGFTPL 546



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 54/160 (33%), Positives = 79/160 (49%)

Query: 132 KLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIH 191
           K  +V+  L    +PD       T LH +  EG + +   L+EAGA          T +H
Sbjct: 488 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 547

Query: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
            A++ G+LDV KLLL + A   +  K   T LHVA    + + A  L+   A  +A  + 
Sbjct: 548 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 607

Query: 252 GDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           G TPLH A + N+ ++   L+ YGA+ NI    G TP+ L
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL 647



 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 1/190 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKL 172
           + ITE    P  + AA    L +V   L +  +PDV +    TALH A   G + +V  L
Sbjct: 404 QAITESGLTPIHV-AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462

Query: 173 MEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHY 232
           +  GA ++ R   E T +H ASR G  ++++LLL   A   A      T LH++ R G  
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 522

Query: 233 ECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLV 292
           + A  L+   A  +   ++G TPLH A +     + +LL+   A  +     G TP+ + 
Sbjct: 523 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582

Query: 293 LHWQNGTKAI 302
            H+ N   A+
Sbjct: 583 AHYDNQKVAL 592



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 54/157 (34%), Positives = 83/157 (52%), Gaps = 1/157 (0%)

Query: 136 VEKFLSDKN-NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWAS 194
           V K L DK  NP+       T LH AC +  + ++E L++ GA I+       T IH A+
Sbjct: 359 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 418

Query: 195 RGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDT 254
             G+L+++ LLL  GA     +    TALH+A R G  E    L+   A ++A+ RE  T
Sbjct: 419 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 478

Query: 255 PLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           PLH A RL + ++++LL+ + A  +     G TP+ +
Sbjct: 479 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 515



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 43/150 (28%), Positives = 85/150 (56%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFR 182
           +FL+AA    L  V ++L    + + C++    ALH A  EGH+ +V++L+  G+ ++  
Sbjct: 13  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72

Query: 183 DMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
               +TA+H AS  G  +V+K+L+ +GA I+A+ +   T L++A +  H +  ++L+   
Sbjct: 73  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132

Query: 243 ADLNAKDREGDTPLHDAVRLNRYKMIRLLI 272
           A+ +    +G TPL  A++    + + +L+
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILL 162



 Score = 78.6 bits (192), Expect = 7e-15
 Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 2/181 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ +    L+     ++  +   T LH A  EGH  +V  L++ GA I       
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T++H A++   ++V  +L   GA   A  KL  T L VA   G+ +    L+   A++N
Sbjct: 675 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 734

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           AK + G TPLH A +     +I +L+ +GA  N     G T   L +  + G  ++ D+L
Sbjct: 735 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA--LAIAKRLGYISVVDTL 792

Query: 307 R 307
           +
Sbjct: 793 K 793



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 50/169 (29%), Positives = 86/169 (50%), Gaps = 8/169 (4%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDV--------CDEYKRTALHRACLEGHLAIVE 170
           V +P    AA ++        L + +N DV          E   T LH A   G++ +  
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229

Query: 171 KLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTG 230
            L+  GA ++F      T +H AS+ GN +++KLLL++G +I A+ +   T LH A R+G
Sbjct: 230 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 289

Query: 231 HYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
           H +  E L+   A L A+ + G +PLH A + +  + ++ L+ + A ++
Sbjct: 290 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 46/135 (34%), Positives = 67/135 (49%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH A  +  + I   L+  GA+         T +H AS+ G+ D++ LLL+KGA I  
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 669

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K   T+LH+A +      A+ L    AD +A  + G TPL  A      KM+  L+  
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729

Query: 275 GADLNIKNCAGKTPM 289
           GA++N K   G TP+
Sbjct: 730 GANVNAKTKNGYTPL 744



 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 45/154 (29%), Positives = 80/154 (51%), Gaps = 2/154 (1%)

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
           RA   G+L  V + ++ G  I   +     A+H A++ G++ +++ LL +G+ + +  K 
Sbjct: 16  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
            +TALH+A   G  E  + L+   A++NA+ + G TPL+ A + N   +++ L+  GA+ 
Sbjct: 76  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 135

Query: 279 NIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYK 312
           +     G TP+ + L  Q G       L EN  K
Sbjct: 136 STATEDGFTPLAVAL--QQGHNQAVAILLENDTK 167



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 41/135 (30%), Positives = 68/135 (50%)

Query: 157 LHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARD 216
           LH A    H+  V+ L++  A ++   +   TA+H A+  G+  V KLLL+K A  +AR 
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374

Query: 217 KLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGA 276
               T LH+A +    +  E L+   A + A    G TP+H A  +    ++ LL+  GA
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434

Query: 277 DLNIKNCAGKTPMDL 291
             ++ N  G+T + +
Sbjct: 435 SPDVTNIRGETALHM 449



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 55/202 (27%), Positives = 86/202 (42%), Gaps = 37/202 (18%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEA----------- 175
           AA EN + VV+  L +  N     E   T L  A  +GH   V  L+E            
Sbjct: 116 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 175

Query: 176 --------------------GAQIEFRDMLESTA------IHWASRGGNLDVLKLLLNKG 209
                                A ++ + M+  T       +H A+  GN++V  LLLN+G
Sbjct: 176 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 235

Query: 210 AKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIR 269
           A +    +   T LHVA + G+    + L+     ++AK R+G TPLH A R    +++ 
Sbjct: 236 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 295

Query: 270 LLIMYGADLNIKNCAGKTPMDL 291
           LL+  GA L  +   G +P+ +
Sbjct: 296 LLLERGAPLLARTKNGLSPLHM 317



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 48/167 (28%), Positives = 80/167 (47%), Gaps = 11/167 (6%)

Query: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDM 184
           +K  L++K PV           DV  +Y  TALH A   GH  + + L++  A    R +
Sbjct: 327 VKHLLQHKAPV----------DDVTLDYL-TALHVAAHCGHYRVTKLLLDKRANPNARAL 375

Query: 185 LESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD 244
              T +H A +   + V++LL+  GA I A  +   T +HVA   GH      L+   A 
Sbjct: 376 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 435

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            +  +  G+T LH A R  + +++R L+  GA ++ +    +TP+ +
Sbjct: 436 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 482



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 45/171 (26%), Positives = 76/171 (44%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA    L V +  L  +   D   +   T LH A    +  +   L+E GA         
Sbjct: 549 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 608

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++   + +   LLN GA+ +   K   T LH+A + GH +    L+   A+++
Sbjct: 609 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 668

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              + G T LH A + ++  +  +L  +GAD +     G TP+ +  H+ N
Sbjct: 669 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 719



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 37/200 (18%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E  + +V++ L   ++ D   +   TALH A L G   +V+ L++ GA I  +    
Sbjct: 50  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYEC------------ 234
            T ++ A++  ++DV+K LL  GA  S   +   T L VA++ GH +             
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169

Query: 235 ----AEHLIACEAD---------------------LNAKDREGDTPLHDAVRLNRYKMIR 269
               A H+ A + D                     +N     G TPLH A       +  
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229

Query: 270 LLIMYGADLNIKNCAGKTPM 289
           LL+  GA ++     G TP+
Sbjct: 230 LLLNRGAAVDFTARNGITPL 249


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 50/135 (37%), Positives = 73/135 (54%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH A   GH  +VE L+E GA +  R     + +H A++G +++ +K LL   A +  
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
                 TALHVA   GHY   + L+   A+ NA+   G TPLH A + NR K++ LL+ Y
Sbjct: 361 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 275 GADLNIKNCAGKTPM 289
           GA +     +G TP+
Sbjct: 421 GASIQAITESGLTPI 435



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 58/191 (30%), Positives = 93/191 (48%), Gaps = 1/191 (0%)

Query: 99  YRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALH 158
           YR TK+ + K   P         P  + A  +N++ V+E  +    +     E   T +H
Sbjct: 378 YRVTKLLLDKRANPNARALNGFTPLHI-ACKKNRIKVMELLVKYGASIQAITESGLTPIH 436

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
            A   GHL IV  L++ GA  +  ++   TA+H A+R G ++V++ LL  GA + AR + 
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE 496

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
             T LH+A R G  E  + L+   A  +A    G TPLH + R  +  +  +L+  GA  
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556

Query: 279 NIKNCAGKTPM 289
           ++    G TP+
Sbjct: 557 SLATKKGFTPL 567



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 54/160 (33%), Positives = 79/160 (49%)

Query: 132 KLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIH 191
           K  +V+  L    +PD       T LH +  EG + +   L+EAGA          T +H
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568

Query: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
            A++ G+LDV KLLL + A   +  K   T LHVA    + + A  L+   A  +A  + 
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628

Query: 252 GDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           G TPLH A + N+ ++   L+ YGA+ NI    G TP+ L
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL 668



 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 1/190 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKL 172
           + ITE    P  + AA    L +V   L +  +PDV +    TALH A   G + +V  L
Sbjct: 425 QAITESGLTPIHV-AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 173 MEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHY 232
           +  GA ++ R   E T +H ASR G  ++++LLL   A   A      T LH++ R G  
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 233 ECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLV 292
           + A  L+   A  +   ++G TPLH A +     + +LL+   A  +     G TP+ + 
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603

Query: 293 LHWQNGTKAI 302
            H+ N   A+
Sbjct: 604 AHYDNQKVAL 613



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 54/157 (34%), Positives = 83/157 (52%), Gaps = 1/157 (0%)

Query: 136 VEKFLSDKN-NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWAS 194
           V K L DK  NP+       T LH AC +  + ++E L++ GA I+       T IH A+
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439

Query: 195 RGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDT 254
             G+L+++ LLL  GA     +    TALH+A R G  E    L+   A ++A+ RE  T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499

Query: 255 PLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           PLH A RL + ++++LL+ + A  +     G TP+ +
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 536



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 43/150 (28%), Positives = 85/150 (56%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFR 182
           +FL+AA    L  V ++L    + + C++    ALH A  EGH+ +V++L+  G+ ++  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 183 DMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
               +TA+H AS  G  +V+K+L+ +GA I+A+ +   T L++A +  H +  ++L+   
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 243 ADLNAKDREGDTPLHDAVRLNRYKMIRLLI 272
           A+ +    +G TPL  A++    + + +L+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 78.6 bits (192), Expect = 7e-15
 Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 2/181 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ +    L+     ++  +   T LH A  EGH  +V  L++ GA I       
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T++H A++   ++V  +L   GA   A  KL  T L VA   G+ +    L+   A++N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           AK + G TPLH A +     +I +L+ +GA  N     G T   L +  + G  ++ D+L
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA--LAIAKRLGYISVVDTL 813

Query: 307 R 307
           +
Sbjct: 814 K 814



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 50/169 (29%), Positives = 86/169 (50%), Gaps = 8/169 (4%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDV--------CDEYKRTALHRACLEGHLAIVE 170
           V +P    AA ++        L + +N DV          E   T LH A   G++ +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 171 KLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTG 230
            L+  GA ++F      T +H AS+ GN +++KLLL++G +I A+ +   T LH A R+G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310

Query: 231 HYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
           H +  E L+   A L A+ + G +PLH A + +  + ++ L+ + A ++
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 46/135 (34%), Positives = 67/135 (49%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH A  +  + I   L+  GA+         T +H AS+ G+ D++ LLL+KGA I  
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K   T+LH+A +      A+ L    AD +A  + G TPL  A      KM+  L+  
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 275 GADLNIKNCAGKTPM 289
           GA++N K   G TP+
Sbjct: 751 GANVNAKTKNGYTPL 765



 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 45/154 (29%), Positives = 80/154 (51%), Gaps = 2/154 (1%)

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
           RA   G+L  V + ++ G  I   +     A+H A++ G++ +++ LL +G+ + +  K 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
            +TALH+A   G  E  + L+   A++NA+ + G TPL+ A + N   +++ L+  GA+ 
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 279 NIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYK 312
           +     G TP+ + L  Q G       L EN  K
Sbjct: 157 STATEDGFTPLAVAL--QQGHNQAVAILLENDTK 188



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 41/135 (30%), Positives = 68/135 (50%)

Query: 157 LHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARD 216
           LH A    H+  V+ L++  A ++   +   TA+H A+  G+  V KLLL+K A  +AR 
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395

Query: 217 KLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGA 276
               T LH+A +    +  E L+   A + A    G TP+H A  +    ++ LL+  GA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455

Query: 277 DLNIKNCAGKTPMDL 291
             ++ N  G+T + +
Sbjct: 456 SPDVTNIRGETALHM 470



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 55/202 (27%), Positives = 86/202 (42%), Gaps = 37/202 (18%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEA----------- 175
           AA EN + VV+  L +  N     E   T L  A  +GH   V  L+E            
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196

Query: 176 --------------------GAQIEFRDMLESTA------IHWASRGGNLDVLKLLLNKG 209
                                A ++ + M+  T       +H A+  GN++V  LLLN+G
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 210 AKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIR 269
           A +    +   T LHVA + G+    + L+     ++AK R+G TPLH A R    +++ 
Sbjct: 257 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 316

Query: 270 LLIMYGADLNIKNCAGKTPMDL 291
           LL+  GA L  +   G +P+ +
Sbjct: 317 LLLERGAPLLARTKNGLSPLHM 338



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 48/167 (28%), Positives = 80/167 (47%), Gaps = 11/167 (6%)

Query: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDM 184
           +K  L++K PV           DV  +Y  TALH A   GH  + + L++  A    R +
Sbjct: 348 VKHLLQHKAPV----------DDVTLDYL-TALHVAAHCGHYRVTKLLLDKRANPNARAL 396

Query: 185 LESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD 244
              T +H A +   + V++LL+  GA I A  +   T +HVA   GH      L+   A 
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            +  +  G+T LH A R  + +++R L+  GA ++ +    +TP+ +
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 45/171 (26%), Positives = 76/171 (44%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA    L V +  L  +   D   +   T LH A    +  +   L+E GA         
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++   + +   LLN GA+ +   K   T LH+A + GH +    L+   A+++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              + G T LH A + ++  +  +L  +GAD +     G TP+ +  H+ N
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 37/200 (18%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E  + +V++ L   ++ D   +   TALH A L G   +V+ L++ GA I  +    
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYEC------------ 234
            T ++ A++  ++DV+K LL  GA  S   +   T L VA++ GH +             
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 235 ----AEHLIACEAD---------------------LNAKDREGDTPLHDAVRLNRYKMIR 269
               A H+ A + D                     +N     G TPLH A       +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 270 LLIMYGADLNIKNCAGKTPM 289
           LL+  GA ++     G TP+
Sbjct: 251 LLLNRGAAVDFTARNGITPL 270


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 50/135 (37%), Positives = 73/135 (54%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH A   GH  +VE L+E GA +  R     + +H A++G +++ +K LL   A +  
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDD 360

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
                 TALHVA   GHY   + L+   A+ NA+   G TPLH A + NR K++ LL+ Y
Sbjct: 361 VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKY 420

Query: 275 GADLNIKNCAGKTPM 289
           GA +     +G TP+
Sbjct: 421 GASIQAITESGLTPI 435



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 58/191 (30%), Positives = 93/191 (48%), Gaps = 1/191 (0%)

Query: 99  YRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALH 158
           YR TK+ + K   P         P  + A  +N++ V+E  +    +     E   T +H
Sbjct: 378 YRVTKLLLDKRANPNARALNGFTPLHI-ACKKNRIKVMELLVKYGASIQAITESGLTPIH 436

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
            A   GHL IV  L++ GA  +  ++   TA+H A+R G ++V++ LL  GA + AR + 
Sbjct: 437 VAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARARE 496

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
             T LH+A R G  E  + L+   A  +A    G TPLH + R  +  +  +L+  GA  
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAH 556

Query: 279 NIKNCAGKTPM 289
           ++    G TP+
Sbjct: 557 SLATKKGFTPL 567



 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 54/160 (33%), Positives = 79/160 (49%)

Query: 132 KLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIH 191
           K  +V+  L    +PD       T LH +  EG + +   L+EAGA          T +H
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568

Query: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
            A++ G+LDV KLLL + A   +  K   T LHVA    + + A  L+   A  +A  + 
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628

Query: 252 GDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           G TPLH A + N+ ++   L+ YGA+ NI    G TP+ L
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL 668



 Score = 81.6 bits (200), Expect = 8e-16
 Identities = 58/190 (30%), Positives = 90/190 (47%), Gaps = 1/190 (0%)

Query: 113 EIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKL 172
           + ITE    P  + AA    L +V   L +  +PDV +    TALH A   G + +V  L
Sbjct: 425 QAITESGLTPIHV-AAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483

Query: 173 MEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHY 232
           +  GA ++ R   E T +H ASR G  ++++LLL   A   A      T LH++ R G  
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQV 543

Query: 233 ECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLV 292
           + A  L+   A  +   ++G TPLH A +     + +LL+   A  +     G TP+ + 
Sbjct: 544 DVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603

Query: 293 LHWQNGTKAI 302
            H+ N   A+
Sbjct: 604 AHYDNQKVAL 613



 Score = 80.1 bits (196), Expect = 2e-15
 Identities = 54/157 (34%), Positives = 83/157 (52%), Gaps = 1/157 (0%)

Query: 136 VEKFLSDKN-NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWAS 194
           V K L DK  NP+       T LH AC +  + ++E L++ GA I+       T IH A+
Sbjct: 380 VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAA 439

Query: 195 RGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDT 254
             G+L+++ LLL  GA     +    TALH+A R G  E    L+   A ++A+ RE  T
Sbjct: 440 FMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQT 499

Query: 255 PLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           PLH A RL + ++++LL+ + A  +     G TP+ +
Sbjct: 500 PLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI 536



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 43/150 (28%), Positives = 85/150 (56%)

Query: 123 TFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFR 182
           +FL+AA    L  V ++L    + + C++    ALH A  EGH+ +V++L+  G+ ++  
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 183 DMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACE 242
               +TA+H AS  G  +V+K+L+ +GA I+A+ +   T L++A +  H +  ++L+   
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153

Query: 243 ADLNAKDREGDTPLHDAVRLNRYKMIRLLI 272
           A+ +    +G TPL  A++    + + +L+
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 78.6 bits (192), Expect = 7e-15
 Identities = 53/181 (29%), Positives = 88/181 (48%), Gaps = 2/181 (1%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA +N++ +    L+     ++  +   T LH A  EGH  +V  L++ GA I       
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T++H A++   ++V  +L   GA   A  KL  T L VA   G+ +    L+   A++N
Sbjct: 696 LTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQNGTKAIFDSL 306
           AK + G TPLH A +     +I +L+ +GA  N     G T   L +  + G  ++ D+L
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTA--LAIAKRLGYISVVDTL 813

Query: 307 R 307
           +
Sbjct: 814 K 814



 Score = 72.8 bits (177), Expect = 4e-13
 Identities = 50/169 (29%), Positives = 86/169 (50%), Gaps = 8/169 (4%)

Query: 119 VDVPTFLKAALENKLPVVEKFLSDKNNPDV--------CDEYKRTALHRACLEGHLAIVE 170
           V +P    AA ++        L + +N DV          E   T LH A   G++ +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 171 KLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTG 230
            L+  GA ++F      T +H AS+ GN +++KLLL++G +I A+ +   T LH A R+G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310

Query: 231 HYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLN 279
           H +  E L+   A L A+ + G +PLH A + +  + ++ L+ + A ++
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359



 Score = 72.4 bits (176), Expect = 5e-13
 Identities = 46/135 (34%), Positives = 67/135 (49%)

Query: 155 TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           T LH A  +  + I   L+  GA+         T +H AS+ G+ D++ LLL+KGA I  
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHM 690

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
             K   T+LH+A +      A+ L    AD +A  + G TPL  A      KM+  L+  
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750

Query: 275 GADLNIKNCAGKTPM 289
           GA++N K   G TP+
Sbjct: 751 GANVNAKTKNGYTPL 765



 Score = 68.2 bits (165), Expect = 9e-12
 Identities = 45/154 (29%), Positives = 80/154 (51%), Gaps = 2/154 (1%)

Query: 159 RACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKL 218
           RA   G+L  V + ++ G  I   +     A+H A++ G++ +++ LL +G+ + +  K 
Sbjct: 37  RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96

Query: 219 LSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADL 278
            +TALH+A   G  E  + L+   A++NA+ + G TPL+ A + N   +++ L+  GA+ 
Sbjct: 97  GNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQ 156

Query: 279 NIKNCAGKTPMDLVLHWQNGTKAIFDSLRENSYK 312
           +     G TP+ + L  Q G       L EN  K
Sbjct: 157 STATEDGFTPLAVAL--QQGHNQAVAILLENDTK 188



 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 41/135 (30%), Positives = 68/135 (50%)

Query: 157 LHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARD 216
           LH A    H+  V+ L++  A ++   +   TA+H A+  G+  V KLLL+K A  +AR 
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395

Query: 217 KLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGA 276
               T LH+A +    +  E L+   A + A    G TP+H A  +    ++ LL+  GA
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455

Query: 277 DLNIKNCAGKTPMDL 291
             ++ N  G+T + +
Sbjct: 456 SPDVTNIRGETALHM 470



 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 55/202 (27%), Positives = 86/202 (42%), Gaps = 37/202 (18%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEA----------- 175
           AA EN + VV+  L +  N     E   T L  A  +GH   V  L+E            
Sbjct: 137 AAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPAL 196

Query: 176 --------------------GAQIEFRDMLESTA------IHWASRGGNLDVLKLLLNKG 209
                                A ++ + M+  T       +H A+  GN++V  LLLN+G
Sbjct: 197 HIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRG 256

Query: 210 AKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIR 269
           A +    +   T LHVA + G+    + L+     ++AK R+G TPLH A R    +++ 
Sbjct: 257 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 316

Query: 270 LLIMYGADLNIKNCAGKTPMDL 291
           LL+  GA L  +   G +P+ +
Sbjct: 317 LLLERGAPLLARTKNGLSPLHM 338



 Score = 62.8 bits (151), Expect = 4e-10
 Identities = 48/167 (28%), Positives = 80/167 (47%), Gaps = 11/167 (6%)

Query: 125 LKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDM 184
           +K  L++K PV           DV  +Y  TALH A   GH  + + L++  A    R +
Sbjct: 348 VKHLLQHKAPV----------DDVTLDYL-TALHVAAHCGHYRVTKLLLDKRANPNARAL 396

Query: 185 LESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEAD 244
              T +H A +   + V++LL+  GA I A  +   T +HVA   GH      L+   A 
Sbjct: 397 NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456

Query: 245 LNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
            +  +  G+T LH A R  + +++R L+  GA ++ +    +TP+ +
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 45/171 (26%), Positives = 76/171 (44%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA    L V +  L  +   D   +   T LH A    +  +   L+E GA         
Sbjct: 570 AAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNG 629

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLN 246
            T +H A++   + +   LLN GA+ +   K   T LH+A + GH +    L+   A+++
Sbjct: 630 YTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH 689

Query: 247 AKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDLVLHWQN 297
              + G T LH A + ++  +  +L  +GAD +     G TP+ +  H+ N
Sbjct: 690 MSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGN 740



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 52/200 (26%), Positives = 83/200 (41%), Gaps = 37/200 (18%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA E  + +V++ L   ++ D   +   TALH A L G   +V+ L++ GA I  +    
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYEC------------ 234
            T ++ A++  ++DV+K LL  GA  S   +   T L VA++ GH +             
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 235 ----AEHLIACEAD---------------------LNAKDREGDTPLHDAVRLNRYKMIR 269
               A H+ A + D                     +N     G TPLH A       +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 270 LLIMYGADLNIKNCAGKTPM 289
           LL+  GA ++     G TP+
Sbjct: 251 LLLNRGAAVDFTARNGITPL 270


>gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens]
          Length = 385

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 75/280 (26%), Positives = 130/280 (46%), Gaps = 23/280 (8%)

Query: 17  NGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLE 76
           NG  G+FL E+    EY   V     E + +L        E ++K    ++A L +K+L 
Sbjct: 109 NGRDGKFLDEERLLREYPQPVG----EGVPSL--------EFRYKKRVYKQASLDEKQLA 156

Query: 77  QRSKLENLEDLEIIIQLKKRKKYRKTKV----PVVKEPEPEIITEPVDVPTFLKAALENK 132
           +     NL+     IQ +  +K  K       P   +PE        + P  L A L++ 
Sbjct: 157 KLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETG------ETPLTLAAQLDDS 210

Query: 133 LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI-H 191
           + V++   +   + D   +   TALH+A    +   ++ L+E GA  +++D    T + H
Sbjct: 211 VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270

Query: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
            A  GG+    +LLL++ A +  +D+     +H A R GH +  EHL+   AD++A++  
Sbjct: 271 TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNAS 330

Query: 252 GDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
           G+T LH     N+    R+L+  G +  +KN   +TP  +
Sbjct: 331 GNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 84.3 bits (207), Expect = 1e-16
 Identities = 56/139 (40%), Positives = 78/139 (56%), Gaps = 3/139 (2%)

Query: 156 ALHRACLEGHLAIVEKLMEAGAQIEFRDML--ESTAIHWASRGGNLDVLKLLLNKGAKIS 213
           AL  A  +G LA V+KL      +  RD     ST +H A+   NL+V + LL  GA ++
Sbjct: 648 ALLDAAKKGCLARVKKLSSPD-NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 214 ARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIM 273
           A+DK     LH A   GH + A  LI   A +NA D+   TPLH+A +  R ++  LL+ 
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766

Query: 274 YGADLNIKNCAGKTPMDLV 292
           +GAD  +KN  G+TP+DLV
Sbjct: 767 HGADPTLKNQEGQTPLDLV 785



 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 57/153 (37%), Positives = 83/153 (54%), Gaps = 6/153 (3%)

Query: 157 LHRACLEGHLAIVEKLMEAGAQIEFRDM--LESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           L  A   G +  V+KL    + +  RD+   +ST +H+A+    + V++ LL  GA + A
Sbjct: 496 LLEAAKAGDVETVKKLCTVQS-VNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHA 554

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
           +DK     LH A   GHYE AE L+   A +N  D    TPLH+A    +Y++ +LL+ +
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614

Query: 275 GADLNIKNCAGKTPMDLVLHWQNGTKAIFDSLR 307
           GAD   KN  G TP+DLV   ++G   I D LR
Sbjct: 615 GADPTKKNRDGNTPLDLV---KDGDTDIQDLLR 644



 Score = 79.3 bits (194), Expect = 4e-15
 Identities = 50/142 (35%), Positives = 73/142 (51%), Gaps = 1/142 (0%)

Query: 151 EYKRTALHRACLEGHLA-IVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKG 209
           EYK+  L  +   G+   ++  L          D  +ST +H A+    + +++LLL  G
Sbjct: 175 EYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHG 234

Query: 210 AKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIR 269
           A + A+DK     LH A   GHYE  E L+   A +NA D    TPLH+A   NR ++  
Sbjct: 235 ADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCS 294

Query: 270 LLIMYGADLNIKNCAGKTPMDL 291
           LL+ YGAD  + NC  K+ +DL
Sbjct: 295 LLLSYGADPTLLNCHNKSAIDL 316



 Score = 75.1 bits (183), Expect = 8e-14
 Identities = 48/137 (35%), Positives = 73/137 (53%), Gaps = 3/137 (2%)

Query: 157 LHRACLEGHLAIVEKLMEAGAQIEFRDML--ESTAIHWASRGGNLDVLKLLLNKGAKISA 214
           L  AC  G +  V++L+    ++  RD    +ST +H+A+  G  DV++ LL  GA + A
Sbjct: 28  LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86

Query: 215 RDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKMIRLLIMY 274
           RD      LH A   GH E    L+   AD NA+D    TPLH+A    +  +  +L+ +
Sbjct: 87  RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146

Query: 275 GADLNIKNCAGKTPMDL 291
           GA+  I+N  G+T +DL
Sbjct: 147 GAEPTIRNTDGRTALDL 163



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 56/176 (31%), Positives = 82/176 (46%), Gaps = 21/176 (11%)

Query: 135 VVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWAS 194
           VVE  L +  N    D+     LH AC  GH  +V  L+  GA    RD    T +H A+
Sbjct: 73  VVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAA 132

Query: 195 RGGNLDVLKLLLNKGAKISARDKLLSTALHV------AVRTGHYECAEHLIACEA----- 243
             G +DV  +LL  GA+ + R+    TAL +      AV TG Y+  E L +  +     
Sbjct: 133 IKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEK 192

Query: 244 ----------DLNAKDREGDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPM 289
                     + +A D    TPLH A   NR K+++LL+ +GAD++ K+     P+
Sbjct: 193 MMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPL 248



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 45/144 (31%), Positives = 67/144 (46%), Gaps = 3/144 (2%)

Query: 151 EYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGG---NLDVLKLLLN 207
           E+K  +L +A  E  +  ++K +              TA+H A+         + +LLL 
Sbjct: 329 EFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLR 388

Query: 208 KGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYKM 267
           KGA I+ + K   T LHVA    H +  E ++  EA +NA D  G T LH A      + 
Sbjct: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448

Query: 268 IRLLIMYGADLNIKNCAGKTPMDL 291
            RLL+ YG D NI +  G T + +
Sbjct: 449 CRLLLSYGCDPNIISLQGFTALQM 472



 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 52/164 (31%), Positives = 81/164 (49%), Gaps = 3/164 (1%)

Query: 95  KRKKYRKTKVPVVKEPEPEIITEPVDVPTFLKAALENKLPVVEKFLSDKNNPDVCDEYKR 154
           K+ +   T + +VK+ + +I          L AA +  L  V+K LS  +N +  D   R
Sbjct: 620 KKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKK-LSSPDNVNCRDTQGR 678

Query: 155 --TALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKI 212
             T LH A    +L + E L++ GA +  +D      +H A+  G++DV  LL+   A +
Sbjct: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738

Query: 213 SARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPL 256
           +A DK   T LH A + G  +    L+A  AD   K++EG TPL
Sbjct: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPL 782



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 41/133 (30%), Positives = 68/133 (51%), Gaps = 1/133 (0%)

Query: 125 LKAALENKLPVVEKFLSDKN-NPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRD 183
           L+AA    +  V+K  + ++ N    +  + T LH A     +++VE L++ GA +  +D
Sbjct: 497 LEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKD 556

Query: 184 MLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEA 243
                 +H A   G+ +V +LL+  GA ++  D    T LH A   G YE  + L+   A
Sbjct: 557 KGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGA 616

Query: 244 DLNAKDREGDTPL 256
           D   K+R+G+TPL
Sbjct: 617 DPTKKNRDGNTPL 629



 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 48/187 (25%), Positives = 80/187 (42%), Gaps = 24/187 (12%)

Query: 127 AALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLE 186
           AA  N++ +V+  L    +    D+     LH AC  GH  + E L++ GA +   D+ +
Sbjct: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277

Query: 187 STAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTG-----HYECAEHLI-- 239
            T +H A+    ++V  LLL+ GA  +  +    +A+ +A          YE   H +  
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337

Query: 240 -ACEADLN-------------AKDREGDTPLHDAVRL---NRYKMIRLLIMYGADLNIKN 282
            A EAD+                 +  +T LH A       R ++  LL+  GA++N K 
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397

Query: 283 CAGKTPM 289
               TP+
Sbjct: 398 KEFLTPL 404


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,816,159
Number of Sequences: 37866
Number of extensions: 522005
Number of successful extensions: 6432
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 387
Number of HSP's successfully gapped in prelim test: 176
Number of HSP's that attempted gapping in prelim test: 2914
Number of HSP's gapped (non-prelim): 2340
length of query: 319
length of database: 18,247,518
effective HSP length: 102
effective length of query: 217
effective length of database: 14,385,186
effective search space: 3121585362
effective search space used: 3121585362
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.