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Search of human proteins with 38176300
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38176300 nestin [Homo sapiens]
(1621 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38176300 nestin [Homo sapiens] 3210 0.0
gi|112382239 desmuslin isoform B [Homo sapiens] 135 4e-31
gi|112382237 desmuslin isoform A [Homo sapiens] 135 4e-31
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 128 4e-29
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 128 4e-29
gi|62414289 vimentin [Homo sapiens] 126 2e-28
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 120 1e-26
gi|21264345 peripherin [Homo sapiens] 120 1e-26
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 115 3e-25
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 114 8e-25
gi|14249342 internexin neuronal intermediate filament protein, a... 112 3e-24
gi|55749932 desmin [Homo sapiens] 108 3e-23
gi|21735548 centrosomal protein 2 [Homo sapiens] 102 3e-21
gi|148746195 trichohyalin [Homo sapiens] 100 9e-21
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 96 2e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 96 2e-19
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 96 4e-19
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 94 1e-18
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 92 5e-18
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 91 9e-18
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 91 1e-17
gi|71061468 centromere protein E [Homo sapiens] 90 2e-17
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 89 3e-17
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 89 3e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 89 3e-17
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 89 5e-17
gi|119220598 apolipoprotein B48 receptor [Homo sapiens] 89 5e-17
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 88 6e-17
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 87 1e-16
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 86 3e-16
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 3210 bits (8322), Expect = 0.0
Identities = 1621/1621 (100%), Positives = 1621/1621 (100%)
Query: 1 MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDEL 60
MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDEL
Sbjct: 1 MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDEL 60
Query: 61 AALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEK 120
AALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEK
Sbjct: 61 AALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEK 120
Query: 121 CARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELAR 180
CARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELAR
Sbjct: 121 CARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELAR 180
Query: 181 RLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRA 240
RLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRA
Sbjct: 181 RLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRA 240
Query: 241 ALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVA 300
ALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVA
Sbjct: 241 ALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVA 300
Query: 301 TYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPL 360
TYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPL
Sbjct: 301 TYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPL 360
Query: 361 PATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGG 420
PATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGG
Sbjct: 361 PATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGG 420
Query: 421 RKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAK 480
RKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAK
Sbjct: 421 RKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAK 480
Query: 481 DGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVP 540
DGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVP
Sbjct: 481 DGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVP 540
Query: 541 LEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDV 600
LEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDV
Sbjct: 541 LEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDV 600
Query: 601 EVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSL 660
EVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSL
Sbjct: 601 EVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSL 660
Query: 661 QENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQE 720
QENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQE
Sbjct: 661 QENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQE 720
Query: 721 PLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPP 780
PLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPP
Sbjct: 721 PLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPP 780
Query: 781 EKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETL 840
EKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETL
Sbjct: 781 EKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETL 840
Query: 841 KSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNL 900
KSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNL
Sbjct: 841 KSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNL 900
Query: 901 ENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQE 960
ENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQE
Sbjct: 901 ENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQE 960
Query: 961 LAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPK 1020
LAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPK
Sbjct: 961 LAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPK 1020
Query: 1021 EQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASP 1080
EQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASP
Sbjct: 1021 EQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASP 1080
Query: 1081 EVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGP 1140
EVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGP
Sbjct: 1081 EVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGP 1140
Query: 1141 RKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAP 1200
RKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAP
Sbjct: 1141 RKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAP 1200
Query: 1201 SPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVE 1260
SPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVE
Sbjct: 1201 SPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVE 1260
Query: 1261 SEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQR 1320
SEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQR
Sbjct: 1261 SEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQR 1320
Query: 1321 PPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLP 1380
PPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLP
Sbjct: 1321 PPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLP 1380
Query: 1381 GVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPG 1440
GVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPG
Sbjct: 1381 GVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPG 1440
Query: 1441 SSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEE 1500
SSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEE
Sbjct: 1441 SSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEE 1500
Query: 1501 ESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQS 1560
ESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQS
Sbjct: 1501 ESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQS 1560
Query: 1561 EEVGQGMPLVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQREGDRESWSSGE 1620
EEVGQGMPLVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQREGDRESWSSGE
Sbjct: 1561 EEVGQGMPLVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQREGDRESWSSGE 1620
Query: 1621 D 1621
D
Sbjct: 1621 D 1621
>gi|112382239 desmuslin isoform B [Homo sapiens]
Length = 1253
Score = 135 bits (339), Expect = 4e-31
Identities = 106/312 (33%), Positives = 152/312 (48%), Gaps = 6/312 (1%)
Query: 6 GEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSAD-TSWRAHADDELAALR 64
G E ++ ELN RL Y+ RV+ LE +N LL EL G R + +A +E +LR
Sbjct: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLR 68
Query: 65 ALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARA 124
+D+ AE RD L EL + + R AR R E+ +R ++ ARA
Sbjct: 69 QQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARA 128
Query: 125 WLSSQVAELERELEALRVAHEEERVGLNAQAACAP-RCPAPPRGPPAPAPEVEEL----A 179
L + + L+ E L AHE + L A+AA A GP AP P + E+ A
Sbjct: 129 ALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYA 188
Query: 180 RRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERR 239
+ E+WR V+ Y++ V +E +L + +E +A + R E + L+ E GL + R
Sbjct: 189 LLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLR 248
Query: 240 AALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEV 299
A LE L +E E+ Q ++ LE EK L +A L Q L +K LSLEV
Sbjct: 249 ARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEV 308
Query: 300 ATYRTLLEAENS 311
ATYR LLE E++
Sbjct: 309 ATYRALLEGESN 320
>gi|112382237 desmuslin isoform A [Homo sapiens]
Length = 1565
Score = 135 bits (339), Expect = 4e-31
Identities = 106/312 (33%), Positives = 152/312 (48%), Gaps = 6/312 (1%)
Query: 6 GEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSAD-TSWRAHADDELAALR 64
G E ++ ELN RL Y+ RV+ LE +N LL EL G R + +A +E +LR
Sbjct: 9 GPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARCAEEARSLR 68
Query: 65 ALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARA 124
+D+ AE RD L EL + + R AR R E+ +R ++ ARA
Sbjct: 69 QQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQRELQEALGARA 128
Query: 125 WLSSQVAELERELEALRVAHEEERVGLNAQAACAP-RCPAPPRGPPAPAPEVEEL----A 179
L + + L+ E L AHE + L A+AA A GP AP P + E+ A
Sbjct: 129 ALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRLREVHDSYA 188
Query: 180 RRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERR 239
+ E+WR V+ Y++ V +E +L + +E +A + R E + L+ E GL + R
Sbjct: 189 LLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRREALGLEQLR 248
Query: 240 AALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEV 299
A LE L +E E+ Q ++ LE EK L +A L Q L +K LSLEV
Sbjct: 249 ARLEDALLRMREEYGIQAEERQRVIDCLEDEKATLTLAMADWLRDYQDLLQVKTGLSLEV 308
Query: 300 ATYRTLLEAENS 311
ATYR LLE E++
Sbjct: 309 ATYRALLEGESN 320
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 128 bits (322), Expect = 4e-29
Identities = 95/313 (30%), Positives = 150/313 (47%), Gaps = 5/313 (1%)
Query: 8 ESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALV 67
E +M ELN R +Y+ +V+ LE+QN+ L+AEL LRA+ T EL LR +
Sbjct: 69 ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEP-TKLADVYQAELRELRLRL 127
Query: 68 DQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLS 127
DQ EV RDNLA++L V + Q R +A R+ + AR L
Sbjct: 128 DQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLE 187
Query: 128 SQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRL----G 183
++ LE E+ LR HEEE L Q A P ++E+ +
Sbjct: 188 RKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMAS 247
Query: 184 EAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALE 243
A Y+ + A + + + E L +A A + R +LQ L + L +LE
Sbjct: 248 SNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLE 307
Query: 244 QRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYR 303
+++ + + +R +Q A+ LE+E Q L+ ++A+ L+ Q L ++K++L +E+ATYR
Sbjct: 308 RQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYR 367
Query: 304 TLLEAENSRLQTP 316
LLE E +R+ P
Sbjct: 368 KLLEGEENRITIP 380
Score = 52.4 bits (124), Expect = 4e-06
Identities = 65/270 (24%), Positives = 108/270 (40%), Gaps = 17/270 (6%)
Query: 698 EPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLE------TENHKSLRSLEEQD 751
E +R LE +NK L + + L + Q+ +R L T N L +
Sbjct: 85 EKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNL 144
Query: 752 QETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQE--FLKS 809
+ L T+ ++ Q E + ++ D L LD E R +E+ +E FL+
Sbjct: 145 AQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLE--RKIESLEEEIRFLRK 202
Query: 810 LKEESVEAVKS--LETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEI 867
+ EE V ++ ++ L A + LK TQ +++ A +
Sbjct: 203 IHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHE-AEEWYRSKF 261
Query: 868 QEPLESVEVNQETFRLLEEENQESLRSLGAW--NLENLRSPEEVDKESQRNLEEEENLGK 925
+ ++ N E R + E + R L + +LE+LR E + R EE
Sbjct: 262 ADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREA 321
Query: 926 GEYQESLRSLEEEGQEL--PQSADVQRWED 953
YQE+L LEEEGQ L + +Q ++D
Sbjct: 322 ASYQEALARLEEEGQSLKDEMARHLQEYQD 351
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 128 bits (322), Expect = 4e-29
Identities = 95/313 (30%), Positives = 150/313 (47%), Gaps = 5/313 (1%)
Query: 8 ESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALV 67
E +M ELN R +Y+ +V+ LE+QN+ L+AEL LRA+ T EL LR +
Sbjct: 69 ERAEMMELNDRFASYIEKVRFLEQQNKALAAELNQLRAKEP-TKLADVYQAELRELRLRL 127
Query: 68 DQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLS 127
DQ EV RDNLA++L V + Q R +A R+ + AR L
Sbjct: 128 DQLTANSARLEVERDNLAQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLE 187
Query: 128 SQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRL----G 183
++ LE E+ LR HEEE L Q A P ++E+ +
Sbjct: 188 RKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMAS 247
Query: 184 EAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALE 243
A Y+ + A + + + E L +A A + R +LQ L + L +LE
Sbjct: 248 SNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLE 307
Query: 244 QRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYR 303
+++ + + +R +Q A+ LE+E Q L+ ++A+ L+ Q L ++K++L +E+ATYR
Sbjct: 308 RQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLLNVKLALDIEIATYR 367
Query: 304 TLLEAENSRLQTP 316
LLE E +R+ P
Sbjct: 368 KLLEGEENRITIP 380
Score = 52.4 bits (124), Expect = 4e-06
Identities = 65/270 (24%), Positives = 108/270 (40%), Gaps = 17/270 (6%)
Query: 698 EPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLE------TENHKSLRSLEEQD 751
E +R LE +NK L + + L + Q+ +R L T N L +
Sbjct: 85 EKVRFLEQQNKALAAELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEVERDNL 144
Query: 752 QETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQE--FLKS 809
+ L T+ ++ Q E + ++ D L LD E R +E+ +E FL+
Sbjct: 145 AQDLATVRQKLQDETNLRLEAENNLAAYRQEADEATLARLDLE--RKIESLEEEIRFLRK 202
Query: 810 LKEESVEAVKS--LETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEI 867
+ EE V ++ ++ L A + LK TQ +++ A +
Sbjct: 203 IHEEEVRELQEQLARQQVHVELDVAKPDLTAALKEIRTQYEAMASSNMHE-AEEWYRSKF 261
Query: 868 QEPLESVEVNQETFRLLEEENQESLRSLGAW--NLENLRSPEEVDKESQRNLEEEENLGK 925
+ ++ N E R + E + R L + +LE+LR E + R EE
Sbjct: 262 ADLTDAAARNAELLRQAKHEANDYRRQLQSLTCDLESLRGTNESLERQMREQEERHVREA 321
Query: 926 GEYQESLRSLEEEGQEL--PQSADVQRWED 953
YQE+L LEEEGQ L + +Q ++D
Sbjct: 322 ASYQEALARLEEEGQSLKDEMARHLQEYQD 351
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 126 bits (316), Expect = 2e-28
Identities = 94/319 (29%), Positives = 150/319 (47%), Gaps = 17/319 (5%)
Query: 8 ESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALV 67
E ++ ELN R Y+ +V+ LE+QN++L AEL L+ Q + ++E+ LR V
Sbjct: 103 EKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLY-EEEMRELRRQV 161
Query: 68 DQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLS 127
DQ +K EV RDNLAE++ + + Q+ L RE + R+ V+ AR L
Sbjct: 162 DQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLE 221
Query: 128 SQVAELERELEALRVAHEEERVGLNAQA----------ACAPRCPAPPRGPPAPAPEVEE 177
+V L+ E+ L+ HEEE L AQ P A R V
Sbjct: 222 RKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAA 281
Query: 178 LARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLE 237
+ E W Y+ + A + + + + L +A Q + E R ++Q L E L
Sbjct: 282 KNLQEAEEW------YKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKG 335
Query: 238 RRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSL 297
+LE+++ + +Q + L+ E Q ++ ++A+ L Q L ++KM+L +
Sbjct: 336 TNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDI 395
Query: 298 EVATYRTLLEAENSRLQTP 316
E+ATYR LLE E SR+ P
Sbjct: 396 EIATYRKLLEGEESRISLP 414
Score = 45.8 bits (107), Expect = 3e-04
Identities = 71/319 (22%), Positives = 129/319 (40%), Gaps = 44/319 (13%)
Query: 698 EPLRSLEDENKEAFRSLEKENQEPLKTL----EEEDQSIVRPLETENHKSLRSLEEQDQ- 752
+ +R LE +NK LE+ + L EEE + + R ++ + R E+D
Sbjct: 119 DKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNL 178
Query: 753 -ETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQE--FLKS 809
E + L ++ Q+ E + + VD L LD E R +E+ +E FLK
Sbjct: 179 AEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLE--RKVESLQEEIAFLKK 236
Query: 810 LKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQE 869
L EE ++ L+ +I E + + P+ A L ++ Q + K +QE
Sbjct: 237 LHEEEIQ---ELQAQIQEQHVQIDVD----VSKPDLTAAL---RDVRQQYESVAAKNLQE 286
Query: 870 P-----------LESVEVNQETFRLLEEENQESLRSLGAWNLE--NLRSPEEVDKESQRN 916
E+ N + R ++E+ E R + + E L+ E + R
Sbjct: 287 AEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMRE 346
Query: 917 LEEEENLGKGEYQESLRSLEEEGQELPQ--SADVQRWEDTVEKDQELAQESPPGMAGVEN 974
+EE + YQ+++ L++E Q + + + ++ ++D + L E +E
Sbjct: 347 MEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEG 406
Query: 975 EDE---------AELNLRE 984
E+ + LNLRE
Sbjct: 407 EESRISLPLPNFSSLNLRE 425
Score = 36.6 bits (83), Expect = 0.20
Identities = 60/263 (22%), Positives = 104/263 (39%), Gaps = 48/263 (18%)
Query: 516 VSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQEC 575
V SLQ+EI + L+ +EIQ+ Q ++++ ++ ++ S L + ++
Sbjct: 224 VESLQEEIAFLKKLHEEEIQELQAQIQEQHVQI---DVDVSKPDLTAALRDVRQQYESVA 280
Query: 576 PRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKE---- 631
++L+E E KS D+ +A+ Q K E + +QSL E
Sbjct: 281 AKNLQEAEEWYKS-------KFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDAL 333
Query: 632 ---NQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEA 688
N+ L + + E F Q+ + LQ+ ++++ EE
Sbjct: 334 KGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNM-----------------KEEM 376
Query: 689 LRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLR--- 745
R L +E Q+ L +L+ E K LE E+ I PL + +LR
Sbjct: 377 ARHL-REYQDLL--------NVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETN 427
Query: 746 --SLEEQDQETLRTLEKETQQRR 766
SL D + RTL +T + R
Sbjct: 428 LDSLPLVDTHSKRTLLIKTVETR 450
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 120 bits (300), Expect = 1e-26
Identities = 210/1002 (20%), Positives = 393/1002 (39%), Gaps = 132/1002 (13%)
Query: 2 EGCM------GEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAH 55
EGCM E Q+ LN R Y+ +V+ LE N L E LR Q A S
Sbjct: 85 EGCMVAVATSRSEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGE 144
Query: 56 A-DDELAALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRR 114
+ E+ +R V + + + +++L E++ V R RE R
Sbjct: 145 LYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALAR 204
Query: 115 AVEAEKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPE 174
+ + AR L + L+ E LR H+EE L Q + A + A +
Sbjct: 205 FAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALK 264
Query: 175 VE------ELARRL-GEAWRGAVRG---YQERVAHMETSLGQARERLGRAVQGAREGRLE 224
+ E+ +L G A + ++ ++ R+ + + + + A + E R +
Sbjct: 265 CDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQ 324
Query: 225 LQQLQAERGGLLERRAALEQR---LEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQV 281
LQ E L + +LE++ LE R Q + + +Q A++ L+ E + + ++A
Sbjct: 325 LQARTTELEALKSTKDSLERQRSELEDRHQADIAS---YQEAIQQLDAELRNTKWEMAAQ 381
Query: 282 LEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEG 341
L Q L ++KM+L +E+A YR LLE E R+ G G
Sbjct: 382 LREYQDLLNVKMALDIEIAAYRKLLEGEECRI---GFG---------------------- 416
Query: 342 RRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAV 401
P+ P SLP LP +K++E ++ ++ V
Sbjct: 417 -------PI--PFSLPEGLPKIPSVSTHIKVKSEEKIKV------------VEKSEKETV 455
Query: 402 DAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPE 461
E + ++ ++ T+ K+A E G EE GG+ +EA G+
Sbjct: 456 IVEEQTEETQVTEEVTEEEEKEAKEE--------------EGKEEEGGEEEEAEGGEEET 501
Query: 462 DHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQ 521
SP+ EAK ++ + + + + E ++ + K S ++
Sbjct: 502 KSPPAEEAASPEK---EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAK--SPAKE 556
Query: 522 EIWEEEDLNRKEIQDSQVPLE-KETLKSLGEEIQESLKTLENQSHETLERENQECPRSLE 580
E + E ++++ P E K K+ +E+ E +S E + +E +S
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616
Query: 581 EDLETLKSLEKENKELLKDVEVVRPLEKEAVG--QLKPTGKEDTQTLQSLQKENQELMKS 638
E +K K E+ + P ++EA + K KE+ ++ + + + KS
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKS 676
Query: 639 LEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQE 698
E ++ S ++E +S + +E +SP E+A P+ +E +
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP----EKAKSPVKEEAKT 732
Query: 699 PLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTL 758
P ++ +EA + ++ E KTL+ + P + E E+ + ++
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 759 EKETQQRRRSLGEQDQMTLRPPEK--VDLEPLKSLDQEIARPLENENQEFLKSLKEESVE 816
K ++ + L E + PEK E +KS +E +P E + +E K +EE
Sbjct: 793 VKSPEKAKSPLKED----AKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAP 848
Query: 817 AVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLES-VE 875
A T E K + +E ++P+ +AP EE + A +++P ES VE
Sbjct: 849 A-----TPKTEEKKDSKKE-----EAPKKEAPKPKVEEKKEPA-------VEKPKESKVE 891
Query: 876 VNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSL 935
+E E E+++ + + +P +V+ + +E+ + K E ++
Sbjct: 892 AKKE-----EAEDKKKVPT------PEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940
Query: 936 EEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDE 977
+ E ++A ++ DT E+ + +E P A + +D+
Sbjct: 941 PSKPAEKKEAAPEKK--DTKEEKAKKPEEKPKTEAKAKEDDK 980
Score = 89.4 bits (220), Expect = 3e-17
Identities = 174/870 (20%), Positives = 326/870 (37%), Gaps = 88/870 (10%)
Query: 566 ETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRP-LEKEAVG--QLKPTGKEDT 622
E ERE +E ++ L E + LL+D+ VR L+ EA + + +
Sbjct: 144 ELYEREVREMRGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALA 203
Query: 623 QTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPE 682
+ Q + +L K + E + +QE V L ++ A + + Q R
Sbjct: 204 RFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDAL 263
Query: 683 VGD-EEALRPLTKENQEPLRSLEDENKEAFR-------SLEKENQEPLKTLEEEDQSIVR 734
D ALR + + + +++E FR K N + +++ +EE R
Sbjct: 264 KCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRR 323
Query: 735 PLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQE 794
L+ RT E E + + E+ + L + D+ + Q+
Sbjct: 324 QLQA-----------------RTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQ 366
Query: 795 IARPLENENQEFLKSLKE--ESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTP 852
+ L N E L+E + + +L+ EI K E P P P
Sbjct: 367 LDAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGP---IPFSLP 423
Query: 853 EEINQ--GAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVD 910
E + + ++ + +E ++ VE +++ ++EE+ +E+ + E + EE
Sbjct: 424 EGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEG 483
Query: 911 KESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMA 970
KE + EEEE G E +S + E E + V+ + + + +E A
Sbjct: 484 KEEEGG-EEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542
Query: 971 GVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGAS 1030
V++ ++A+ +E+ + + E+ E + EV P + +SP +E + E S
Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAKS 600
Query: 1031 VKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQA-------SPEVM 1083
+ +++ + +P + + E P E +P ++A SPE
Sbjct: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP--EKAKSPTKEEAKSPEKAKSPEKE 658
Query: 1084 LGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKD 1143
P +S AE + + E+ P EE K ++ K
Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
Query: 1144 LEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAE--EAFPAETLGHTGSDAPS 1201
E+A E ++ P K++ P + E + +A++P A+ + E +A S
Sbjct: 719 PEKAKSPVKEEAKTPEKAKSPVK--EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776
Query: 1202 PWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGV------------ 1249
P E+A+ V + SP +P+ EDA P+ + +E V
Sbjct: 777 PADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVK 836
Query: 1250 -------QGRAEALGKVE----SEQEELGSGEIP------------EGPQEEGEESREES 1286
+ +A A K E S++EE E P E P+E E+++E
Sbjct: 837 EPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE 896
Query: 1287 EEDELGETLPD-STPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAP 1345
ED+ P+ P ++ P+ + T + P KE PA E
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDAKPK-EKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKK 955
Query: 1346 PSEKEEGEEGEEECGRDSDLSEEFEDLGTE 1375
+++E+ ++ EE+ ++ E+ + L E
Sbjct: 956 DTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 120 bits (300), Expect = 1e-26
Identities = 101/352 (28%), Positives = 161/352 (45%), Gaps = 28/352 (7%)
Query: 8 ESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADD----ELAAL 63
E ++ ELN R ++ +V+ LE+QN L EL R Q A AD EL L
Sbjct: 97 EKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEP-----ARADQLCQQELREL 151
Query: 64 RALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCAR 123
R ++ RE+ +V RD LAE+L + R ++ RE + R+ V+ +R
Sbjct: 152 RRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSR 211
Query: 124 AWLSSQVAELERELEALRVAHEEE----RVGLNAQ--------AACAPRCPAPPRGPPAP 171
L ++ L E+E L+ HEEE +V + +Q A P A R A
Sbjct: 212 LELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQ 271
Query: 172 APEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAE 231
+ + E W Y+ + A + + + E L +A Q E R ++Q L E
Sbjct: 272 YESIAAKNLQEAEEW------YKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCE 325
Query: 232 RGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHL 291
GL AL ++L ++ +Q LE+E + L+ ++A+ L Q+L ++
Sbjct: 326 VDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNV 385
Query: 292 KMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRR 343
KM+L +E+ATYR LLE E SR+ P S SL+ + E++ P+ R+
Sbjct: 386 KMALDIEIATYRKLLEGEESRISVP-VHSFASLNIKTTVPEVEPPQDSHSRK 436
Score = 54.3 bits (129), Expect = 9e-07
Identities = 80/298 (26%), Positives = 125/298 (41%), Gaps = 35/298 (11%)
Query: 671 EKENQEPL--RSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEK-ENQEPLKT--- 724
E NQE L RS E + + L E +R LE +N L + QEP +
Sbjct: 84 EALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQL 143
Query: 725 LEEEDQSIVRPLETENHKSLRSLEEQD--QETLRTLEKETQQRRRSLGEQDQMTLRPPEK 782
++E + + R LE + R E+D E L L++ ++ R + + + +
Sbjct: 144 CQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKD 203
Query: 783 VDLEPLKSLDQEIARPLEN--ENQEFLKSLKEESVEAVK-SLETEILESLKSAGQENLET 839
VD L L E+ R +E+ + EFLK L EE + ++ S+E++ ++ Q +E
Sbjct: 204 VDDATLSRL--ELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQ------QVEVEA 255
Query: 840 LKSPETQAPLWTPEEINQGAMNPLEKEIQEPLE-----------SVEVNQETFRLLEEEN 888
PE A L +I + K +QE E + N E R ++E
Sbjct: 256 TVKPELTAAL---RDIRAQYESIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEM 312
Query: 889 QESLRSLGAWNLE--NLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQ 944
ES R + + E LR E R LEE+ L G YQ LEEE ++L +
Sbjct: 313 NESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKE 370
Score = 34.3 bits (77), Expect = 1.0
Identities = 80/356 (22%), Positives = 144/356 (40%), Gaps = 55/356 (15%)
Query: 504 LVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQ 563
L ++ A+ G++ + QE + L ++E+++ L +E L+ LG E +
Sbjct: 118 LEQQNAALRGELSQARGQEPARADQLCQQELRE----LRRE-LELLGRE----------R 162
Query: 564 SHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQ 623
+ER+ L EDL LK +E +D E L ++ V D
Sbjct: 163 DRVQVERDG------LAEDLAALKQRLEEETRKREDAEHNLVLFRKDV---------DDA 207
Query: 624 TLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEV 683
TL L EL + +E ++ F ++E + LQ ++ES + E + ++ PE+
Sbjct: 208 TLSRL-----ELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVK-PEL 261
Query: 684 GDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKS 743
ALR + + + S+ +N + K L + +R + E ++S
Sbjct: 262 --TAALRDIRAQYE----SIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNES 315
Query: 744 LRSLEEQDQET--LRTLEKETQQRRRSLGEQDQMTLRPPEKVDL---EPLKSLDQEIARP 798
R ++ E LR + ++ R L EQ + + E L+ L +E+AR
Sbjct: 316 RRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARH 375
Query: 799 LENENQEFLKSLKEESVE------AVKSLETEILESLKSAGQENLETLKSPETQAP 848
L E QE L +E ++ E+ I + S N++T PE + P
Sbjct: 376 L-REYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLNIKT-TVPEVEPP 429
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 115 bits (289), Expect = 3e-25
Identities = 175/786 (22%), Positives = 315/786 (40%), Gaps = 51/786 (6%)
Query: 8 ESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHA-DDELAALRAL 66
E Q+ LN R Y+ +V LE+QN+ + AE+ LR + A + A D E+ LRA
Sbjct: 101 EKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQEIRELRAT 160
Query: 67 VDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWL 126
++ EK ++ D+L E++ + R ++ R+ T + R+ +E + L
Sbjct: 161 LEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIEEASLVKVEL 220
Query: 127 SSQVAELERELEALRVAHEEERVGLNAQAACA----PRCPAPPRGPPAPAPEVE-ELARR 181
+V L+ E+ LR HEEE L AQ + R E+ +L
Sbjct: 221 DKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDISTALKEIRSQLESH 280
Query: 182 LGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAA 241
+ A ++ R A + + Q +E + A + E R +LQ E + + +
Sbjct: 281 SDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIELESVRGTKES 340
Query: 242 LEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVAT 301
LE++L + +Q ++ LE E +G + ++A+ L Q L ++KM+L +E+A
Sbjct: 341 LERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAA 400
Query: 302 YRTLLEAENSRLQTPGGGSKTSLSFQDPKL----ELQFPR--TPEGRRLGSLLPVLSPTS 355
YR LLE E +R T G L P + ++Q P+ P+ + + + +
Sbjct: 401 YRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEET 460
Query: 356 LPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLL 415
+ +E + A + A+ P+A V A+ A +
Sbjct: 461 KVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEV 520
Query: 416 QTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHS 475
+ + G K+ E E A E GG +E S+ + + +
Sbjct: 521 KEEEGEKEEEEGQEEEEEEDEGAK--SDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578
Query: 476 SLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQ 535
EAK+ + + + E E VEK + V S +E + +
Sbjct: 579 EAEAKEEKKVEEKSEEVATKE-ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEE 637
Query: 536 DSQVPLEKETLKSLGEE------IQESLKTLENQSHETLERENQECPRSLEED----LET 585
+ P+ K ++ G+ ++E K+ ++S E+ P+S E+ E
Sbjct: 638 KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS-PVEEKAKSPVPKSPVEEAKSKAEV 696
Query: 586 LKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQ-----ELMKSLE 640
K +KE +E K+V+ EK + KP + + +S KE + KS++
Sbjct: 697 GKGEQKEEEE--KEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVK 754
Query: 641 GNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPL 700
+LE E +E LQ+ E EK E S E G ++ + KE +
Sbjct: 755 VHLE------KETKEEGKPLQQEKEK----EKAGGEG-GSEEEGSDKGAKGSRKE--DIA 801
Query: 701 RSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETL--RTL 758
+ E E KE +E+E +E EEE + L+ + ++ +++ + +T+
Sbjct: 802 VNGEVEGKE---EVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTV 858
Query: 759 EKETQQ 764
EK T +
Sbjct: 859 EKITSE 864
Score = 72.8 bits (177), Expect = 3e-12
Identities = 174/820 (21%), Positives = 318/820 (38%), Gaps = 134/820 (16%)
Query: 599 DVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVS 658
D ++ R EKE + L + + L+++N+E+ E ++ + +L
Sbjct: 93 DYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEI----EAEIQALRQKQASHAQLGD 148
Query: 659 SLQENLESLTA-LEKENQEPLRSPEVGD--EEALRPLTKENQEPLRSLEDENKEAFRSLE 715
+ + + L A LE N E + D EE + L + +E R L D+ + A R+L
Sbjct: 149 AYDQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEAR-LRDDTEAAIRALR 207
Query: 716 KENQEPLKTLEEEDQSI------VRPLETENHKSLRSLEEQDQETLRTLEKET------- 762
K+ +E E D+ + V L + + + + L Q Q + T+E++
Sbjct: 208 KDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVERKDYLKTDIS 267
Query: 763 ---QQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVK 819
++ R L + E E K ++ E +N+E ++S KEE E +
Sbjct: 268 TALKEIRSQLESHSDQNMHQAE----EWFKCRYAKLTEAAE-QNKEAIRSAKEEIAEYRR 322
Query: 820 SLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQE 879
L+++ +E LE+++ T E + + ++ +E+ L S Q+
Sbjct: 323 QLQSKSIE---------LESVRG--------TKESLER-QLSDIEERHNHDLSSY---QD 361
Query: 880 TFRLLEEE----NQESLRSLGAW-NLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRS 934
T + LE E E R L + +L N++ +++ + R L E E + S+
Sbjct: 362 TIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITG 421
Query: 935 -LEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEE 993
L + S+ +Q+ VE + Q E + E E + E+
Sbjct: 422 PLYTHRPPITISSKIQK--PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEE----ALTA 475
Query: 994 VVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGL 1053
+ E+ ++ EE E E PE +E+ + + VK A +++ EG+ ++
Sbjct: 476 ITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEE------ 529
Query: 1054 QAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGH 1113
E E E+D DQA E E +E G+
Sbjct: 530 ------EEGQEEEEEEDEGAKSDQA--------EEGGSEKEGSSEKEEGE---------- 565
Query: 1114 LTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFS-ELPGKSRDPWEPPREGR 1172
E E E E EAK + +E +++ L + E P K++ P P
Sbjct: 566 -QEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSP-VPKSPVE 623
Query: 1173 EESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLV---SPSP-TYTPI 1228
E+ ++ P+ P E G +P P E+ + VP V SP + +P+
Sbjct: 624 EKGKSPVPKS-----PVEEKG----KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 674
Query: 1229 LEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEESREES-- 1286
E A P P++ + S +AE +GK E ++EE E+ E P+EE E +EE
Sbjct: 675 EEKAKSPVPKSPVEEAKS-----KAE-VGKGEQKEEE--EKEVKEAPKEEKVEKKEEKPK 726
Query: 1287 ------------EEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPP----QGETGKE 1330
+E+ + E + + + +L T P +++ +G + +E
Sbjct: 727 DVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 786
Query: 1331 GWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFE 1370
G D S + + + EG+E E+ ++ E E
Sbjct: 787 GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826
Score = 67.0 bits (162), Expect = 1e-10
Identities = 134/572 (23%), Positives = 242/572 (42%), Gaps = 54/572 (9%)
Query: 543 KETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEV 602
KE ++S EEI E + L+++S E + SLE L ++ E+ N +L +
Sbjct: 307 KEAIRSAKEEIAEYRRQLQSKSIELESVRGTK--ESLERQLSDIE--ERHNHDLSSYQDT 362
Query: 603 VRPLEKEAVGQLKPTGKE--DTQTL----QSLQKENQELMKSLEGNLETF-LFPGTENQE 655
++ LE E G + + Q L +L E K LEG F F G+
Sbjct: 363 IQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGP 422
Query: 656 LV---------SSLQE---NLESLTALEKENQEPLRSPEVGDE--EALRPLTKENQEPLR 701
L S +Q+ L K +E + +V DE E LT +E
Sbjct: 423 LYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAV 482
Query: 702 SLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKE 761
S+++E KEA E++ +EP + EEE + P++ + E+++E + E+E
Sbjct: 483 SMKEEKKEA---AEEKEEEP-EAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEE 538
Query: 762 TQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSL 821
+ +S DQ EK + +QE E ++ +E+ VE KS
Sbjct: 539 EDEGAKS----DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE-KSE 593
Query: 822 ETEILESLKS-AGQENLETLKSPETQAPLWTPEEINQGAM--NPLEKEIQEPLESVEVNQ 878
E E L + A E E KSP ++P+ EE + + +P+E++ + P+ V +
Sbjct: 594 EVATKEELVADAKVEKPEKAKSPVPKSPV---EEKGKSPVPKSPVEEKGKSPVPKSPVEE 650
Query: 879 E-TFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEE 937
+ + + +E +S + + ++ V K + + +GKGE +E E+
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKE---EEEK 707
Query: 938 EGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAE-LNLREQDGFTGKEEVVE 996
E +E P+ V++ E+ + E + P V+ E AE + + + ++E E
Sbjct: 708 EVKEAPKEEKVEKKEEKPKDVPEKKKAESP----VKEEAVAEVVTITKSVKVHLEKETKE 763
Query: 997 QGELNATEEVWIPGEGHPESPEPKEQRGL----VEGASVKGGAEGLQDPEGQSQQVGAPG 1052
+G+ E+ G S E +G E +V G EG ++ E ++++ G+ G
Sbjct: 764 EGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGS-G 822
Query: 1053 LQAPQGLPEAIEPLVEDDVAPGGDQASPEVML 1084
+ +G+ L D GGD++ +V++
Sbjct: 823 REEEKGVVTNGLDLSPADEKKGGDKSEEKVVV 854
Score = 50.8 bits (120), Expect = 1e-05
Identities = 179/855 (20%), Positives = 300/855 (35%), Gaps = 165/855 (19%)
Query: 792 DQEIARPLENENQEFLKSLKEESVEAVKSLETEILE--------SLKSAGQENLETLKSP 843
D +++R E E + L +E V LE + E K A L
Sbjct: 93 DYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAYDQ 152
Query: 844 ETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENL 903
E + T E +N ++ Q L+S + ++ RL E +E+ L
Sbjct: 153 EIRELRATLEMVNH-------EKAQVQLDSDHLEEDIHRLKERFEEEA----------RL 195
Query: 904 RSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQS---------ADVQRWEDT 954
R E + R EE +L K E + ++SL++E L + A +Q T
Sbjct: 196 RDDTEAAIRALRKDIEEASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHIT 255
Query: 955 VEKDQELAQESPPGMAGVEN--EDEAELNLRE-QDGFTGKEEVVEQGELNATEEVWIPGE 1011
VE+ L + + + + E ++ N+ + ++ F + + + E + E
Sbjct: 256 VERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKE 315
Query: 1012 GHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIE------- 1064
E + + +E SV+G E L+ ++ L + Q + +E
Sbjct: 316 EIAEYRRQLQSKS-IELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTK 374
Query: 1065 -----------PLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGH 1113
L+ +A + A+ +L E + AG+ GP P
Sbjct: 375 WEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLY----THRPPI 430
Query: 1114 LTREEVMEPPLE-----------EESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSR 1162
++ +P +E EE +E +V E + ++EEA TE + K
Sbjct: 431 TISSKIQKPKVEAPKLKVQHKFVEEIIEETKV---EDEKSEMEEALTAITEELAVSMK-- 485
Query: 1163 DPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPS 1222
E +E EE E E EAEE+ SP
Sbjct: 486 ---EEKKEAAEEKEEEP-----------------------------EAEEEEVAAKKSPV 513
Query: 1223 PTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGE-- 1280
P +++ G + + EG +E +G A++ E E+ GS E EG QEEGE
Sbjct: 514 KATAPEVKEEEGEKEEEEGQEEEEEEDEG-AKSDQAEEGGSEKEGSSEKEEGEQEEGETE 572
Query: 1281 --------ESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGW 1332
E++EE + +E E + L + P + P P+ ++G
Sbjct: 573 AEAEGEEAEAKEEKKVEEKSEEVATKEEL-----VADAKVEKPEKAKSPVPKSPVEEKGK 627
Query: 1333 DPAVLASEGLEAPPSEKEEG---EEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEP 1389
P ++P EK + + EE G+ E+ G V + P
Sbjct: 628 SPVP------KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSP 681
Query: 1390 LGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQAL 1449
+ + P A + G EEE E E +EE E + P +A
Sbjct: 682 VPKSPV----EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK--PKDVPEKKKAE 735
Query: 1450 SSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLER 1509
S + E +++ SV K LE E+++ +P E+E + E
Sbjct: 736 SPVKEEAVAEVVTITKSV--------------KVHLEKETKEEGKPLQQEKEKEKAGGE- 780
Query: 1510 EDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQGMPL 1569
G E S G + I VNG+ +EGK + G + EE G +
Sbjct: 781 ----GGSEEEGSDKGAKGSRKEDIAVNGE---VEGKEEVEQETKEKGSGREEEKG----V 829
Query: 1570 VSEGDRGSPFQEEEG 1584
V+ G SP E++G
Sbjct: 830 VTNGLDLSPADEKKG 844
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 114 bits (285), Expect = 8e-25
Identities = 90/322 (27%), Positives = 156/322 (48%), Gaps = 5/322 (1%)
Query: 7 EESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTS-WRAHADDELAALRA 65
+E Q+ +LN R +++ RV LE+QN++L AEL LR + ++ S +RA + E+ LR
Sbjct: 89 QEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRL 148
Query: 66 LVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAW 125
+ EK A + R+ L E L + R ++ L+RE + R+ + ARA
Sbjct: 149 AAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAE 208
Query: 126 LSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEA 185
L ++ L E+ L+ HEEE L AQ A P + ++++ + +
Sbjct: 209 LEKRIDSLMDEISFLKKVHEEEIAELQAQIQYAQISVEMDVTKPDLSAALKDIRAQYEKL 268
Query: 186 WRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQR 245
++ +E T L ++ + AV+ A++ E ++L + +E + +
Sbjct: 269 AAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEA 328
Query: 246 LEGRWQE----RLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVAT 301
LE + QE + Q + LE E + +S++A+ L+ Q L ++KM+L +E+A
Sbjct: 329 LEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAA 388
Query: 302 YRTLLEAENSRLQTPGGGSKTS 323
YR LLE E +RL GS TS
Sbjct: 389 YRKLLEGEETRLSFTSVGSITS 410
Score = 56.6 bits (135), Expect = 2e-07
Identities = 93/441 (21%), Positives = 171/441 (38%), Gaps = 60/441 (13%)
Query: 526 EEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQ-SHETLEREN-----QECPRSL 579
E+++ + EK+ L+ E ++E+L+ L+ + E L RE+ E +
Sbjct: 140 EQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGA 199
Query: 580 EEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSL 639
+E LEK L+ ++ ++ + +E + +L Q + Q S+
Sbjct: 200 DEAALARAELEKRIDSLMDEISFLKKVHEEEIAEL--------------QAQIQYAQISV 245
Query: 640 EGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEP 699
E ++ + + ++ E L A +N E L +N +
Sbjct: 246 EMDVTK-----PDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRF---TVLTESAAKNTDA 297
Query: 700 LRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQD-------Q 752
+R+ +DE E+ R L+ KTLE E R + K L+ LE++ Q
Sbjct: 298 VRAAKDEVSESRRLLKA------KTLEIE---ACRGMNEALEKQLQELEDKQNADISAMQ 348
Query: 753 ETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLK-SLDQEIA--RPLENENQEFLKS 809
+T+ LE E + + +M E DL +K +LD EIA R L + L
Sbjct: 349 DTINKLENELRTTK------SEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSF 402
Query: 810 LKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQE 869
S+ + S +++ G + L S + +T + + E++E
Sbjct: 403 TSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEE------QIEVEE 456
Query: 870 PLESVEVNQETFRLLEE-ENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEY 928
+E+ + + E E +E + E EE KE +EEE G+GE
Sbjct: 457 TIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEE 516
Query: 929 QESLRSLEEEGQELPQSADVQ 949
E + EEE +++ + + Q
Sbjct: 517 GEETKEAEEEEKKVEGAGEEQ 537
Score = 53.5 bits (127), Expect = 2e-06
Identities = 122/548 (22%), Positives = 196/548 (35%), Gaps = 90/548 (16%)
Query: 647 LFPGTENQEL--VSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKEN---QEPLR 701
L P EN +L V+++ +L+S+ EK + L E + L ++N + L
Sbjct: 64 LMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELL 123
Query: 702 SLEDENKEA--FRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLE 759
L ++ E FR+L ++ L+ E+ T ++L+ E +ETLR L+
Sbjct: 124 VLRQKHSEPSRFRALYEQEIRDLRLAAED--------ATNEKQALQGEREGLEETLRNLQ 175
Query: 760 KETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVK 819
++ S + + + + D L + E + FLK + EE + ++
Sbjct: 176 ARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQ 235
Query: 820 --------SLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPL 871
S+E ++ + SA +++ + EE + L
Sbjct: 236 AQIQYAQISVEMDVTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLT------- 288
Query: 872 ESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQES 931
ES N + R ++E ES R L A LE E+ R + E ++
Sbjct: 289 ESAAKNTDAVRAAKDEVSESRRLLKAKTLEI---------EACRGMNEA-------LEKQ 332
Query: 932 LRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGK 991
L+ LE++ Q+AD+ +DT+ K + + + MA E + LN++
Sbjct: 333 LQELEDK-----QNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDI--- 384
Query: 992 EEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAP 1051
E+ +L EE + Q V G S GG LQ P
Sbjct: 385 -EIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYGG---LQTSSYLMSTRSFP 440
Query: 1052 GLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDP 1111
E IE VE+ + E A E A P G+ D
Sbjct: 441 SYYTSHVQEEQIE--VEETI---------------EAAKAEEAKDEPPSEGEAEEEEKDK 483
Query: 1112 GHLTREEVMEPP--LEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPR 1169
EE E +EES EAK EE GG G E E K + E
Sbjct: 484 EEAEEEEAAEEEEAAKEESEEAKE-----------EEEGGEGEEGEET--KEAEEEEKKV 530
Query: 1170 EGREESEA 1177
EG E +A
Sbjct: 531 EGAGEEQA 538
Score = 52.4 bits (124), Expect = 4e-06
Identities = 103/488 (21%), Positives = 189/488 (38%), Gaps = 79/488 (16%)
Query: 599 DVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQ----ELMKSLEGNLETFLFPGTENQ 654
D++ +R EK + L + + L+++N+ EL+ + + E F Q
Sbjct: 82 DLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQ 141
Query: 655 ELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSL 714
E + L+ E T ++ L+ G EE LR L +E + S ED +
Sbjct: 142 E-IRDLRLAAEDAT----NEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEAR 196
Query: 715 EKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQ 774
+ ++ L E E + + L E + L++ +E + L+ + Q + S+ E D
Sbjct: 197 KGADEAALARAELEKR--IDSLMDE----ISFLKKVHEEEIAELQAQIQYAQISV-EMD- 248
Query: 775 MTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKS----LKE---ESVEAVKSLETEILE 827
+P L+ +++ +++A +E+ KS L E ++ +AV++ + E+ E
Sbjct: 249 -VTKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSE 307
Query: 828 SLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLES----VEVNQETFRL 883
S + + LE E +G LEK++QE + + Q+T
Sbjct: 308 SRRLLKAKTLEI--------------EACRGMNEALEKQLQELEDKQNADISAMQDTINK 353
Query: 884 LEEENQESLRSLGAW-----NLENLRSPEEVDKESQRNLEEEEN---------------- 922
LE E + + + + +L N++ +++ + R L E E
Sbjct: 354 LENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYS 413
Query: 923 -------------LGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGM 969
L Y S RS Q ++ E E A++ PP
Sbjct: 414 QSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPS- 472
Query: 970 AGVENEDEAELNLREQDGFTGKEEVV-EQGELNATEEVWIPGEGHPESPEPKEQRGLVEG 1028
G E+E + E++ +EE E+ E EE GE E+ E +E+ VEG
Sbjct: 473 EGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEG 532
Query: 1029 ASVKGGAE 1036
A + A+
Sbjct: 533 AGEEQAAK 540
Score = 33.9 bits (76), Expect = 1.3
Identities = 29/107 (27%), Positives = 44/107 (41%), Gaps = 22/107 (20%)
Query: 1259 VESEQEELGSGEIP-EGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTG 1317
+E+ + E E P EG EE E+ +EE+EE+E E + +
Sbjct: 458 IEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAE--------------EEEAAKEESE 503
Query: 1318 EQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSD 1364
E + +G G+EG E EA EK+ GEE+ + D
Sbjct: 504 EAKEEEEGGEGEEG-------EETKEAEEEEKKVEGAGEEQAAKKKD 543
Score = 32.3 bits (72), Expect = 3.8
Identities = 20/46 (43%), Positives = 26/46 (56%), Gaps = 2/46 (4%)
Query: 1250 QGRAEALGKVESEQEELGSGEIPEGPQEEGEESREESE--EDELGE 1293
+G AE K + E EE + E E +EE EE++EE E E E GE
Sbjct: 473 EGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGEEGE 518
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 112 bits (280), Expect = 3e-24
Identities = 88/319 (27%), Positives = 147/319 (46%), Gaps = 10/319 (3%)
Query: 8 ESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHA-DDELAALRAL 66
E Q+ LN R ++ +V LE QN L AEL LR + A+ S EL LRA
Sbjct: 94 EKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQ 153
Query: 67 VDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWL 126
+++ + A + RD LAEE++ + RC++ RE + +R V+ AR L
Sbjct: 154 LEEASSARSQALLERDGLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDL 213
Query: 127 SSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAW 186
+V L EL +R H+EE L A + + A A P++ R + +
Sbjct: 214 EKKVESLLDELAFVRQVHDEEVAELLATLQASSQAAAEVDVTVAK-PDLTSALREIRAQY 272
Query: 187 --------RGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLER 238
+ A Y+ + A++ ++ E + + + E R +LQ E GL
Sbjct: 273 ESLAAKNLQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGA 332
Query: 239 RAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLE 298
+LE+++ + +Q ++ LE + + +S++A+ L Q L ++KM+L +E
Sbjct: 333 NESLERQILELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIE 392
Query: 299 VATYRTLLEAENSRLQTPG 317
+A YR LLE E +R T G
Sbjct: 393 IAAYRKLLEGEETRFSTSG 411
Score = 33.9 bits (76), Expect = 1.3
Identities = 58/265 (21%), Positives = 100/265 (37%), Gaps = 34/265 (12%)
Query: 698 EPLRSLEDENKEA---FRSLEKENQEPLKT---LEEEDQSIVRPLETENHKSLRSLEEQD 751
E + LE +N+ +L + + EP + + E + + LE + ++L E+D
Sbjct: 110 EKVHQLETQNRALEAELAALRQRHAEPSRVGELFQRELRDLRAQLEEASSARSQALLERD 169
Query: 752 --QETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKS 809
E ++ L ++ R ++ VD L LD E + F++
Sbjct: 170 GLAEEVQRLRARCEEESRGREGAERALKAQQRDVDGATLARLDLEKKVESLLDELAFVRQ 229
Query: 810 LKEESVEAVKSLETEILESLKSAGQENLE---TLKSPETQAPLWTPEEINQGAMNPLEKE 866
+ +E V E+L +L+++ Q E T+ P+ + L EI + K
Sbjct: 230 VHDEEV-------AELLATLQASSQAAAEVDVTVAKPDLTSAL---REIRAQYESLAAKN 279
Query: 867 IQEPLE-----------SVEVNQETFRLLEEENQESLRSLGAWNLE--NLRSPEEVDKES 913
+Q E + E R EE E R L A +E LR E +
Sbjct: 280 LQSAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQ 339
Query: 914 QRNLEEEENLGKGEYQESLRSLEEE 938
LEE + YQ+S+ LE +
Sbjct: 340 ILELEERHSAEVAGYQDSIGQLEND 364
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 108 bits (271), Expect = 3e-23
Identities = 86/319 (26%), Positives = 145/319 (45%), Gaps = 17/319 (5%)
Query: 8 ESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALV 67
E ++ ELN R Y+ +V+ LE+QN L+AE+ L+ + + ++EL LR V
Sbjct: 108 EKVELQELNDRFANYIEKVRFLEQQNAALAAEVNRLKGREPTRVAELY-EEELRELRRQV 166
Query: 68 DQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLS 127
+ ++ +V RDNL ++L+ + + Q+ +E +A R V+A AR L
Sbjct: 167 EVLTNQRARVDVERDNLLDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLE 226
Query: 128 SQVAELERELEALRVAHEEERVGLNAQAA----------CAPRCPAPPRGPPAPAPEVEE 177
++ L E+ L+ HEEE L AQ P A R A +
Sbjct: 227 RRIESLNEEIAFLKKVHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAA 286
Query: 178 LARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLE 237
E W Y+ +V+ + + + + L +A Q E R ++Q E L
Sbjct: 287 KNISEAEEW------YKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKG 340
Query: 238 RRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSL 297
+L +++ +Q + LE+E + L+ ++A+ L Q L ++KM+L +
Sbjct: 341 TNDSLMRQMRELEDRFASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDV 400
Query: 298 EVATYRTLLEAENSRLQTP 316
E+ATYR LLE E SR+ P
Sbjct: 401 EIATYRKLLEGEESRINLP 419
Score = 43.9 bits (102), Expect = 0.001
Identities = 61/299 (20%), Positives = 129/299 (43%), Gaps = 18/299 (6%)
Query: 698 EPLRSLEDENKEAFRSLEK-ENQEPLKTLE---EEDQSIVRPLETENHKSLRSLEEQDQ- 752
E +R LE +N + + + +EP + E EE + + R +E ++ R E+D
Sbjct: 124 EKVRFLEQQNAALAAEVNRLKGREPTRVAELYEEELRELRRQVEVLTNQRARVDVERDNL 183
Query: 753 -ETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQE--FLKS 809
+ L+ L+ + Q+ + E + VD L +D E R +E+ N+E FLK
Sbjct: 184 LDDLQRLKAKLQEEIQLKEEAENNLAAFRADVDAATLARIDLE--RRIESLNEEIAFLKK 241
Query: 810 LKEESVEAVKS--LETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEI 867
+ EE + +++ E ++ + + + L+ Q + I++ A + ++
Sbjct: 242 VHEEEIRELQAQLQEQQVQVEMDMSKPDLTAALRDIRAQYETIAAKNISE-AEEWYKSKV 300
Query: 868 QEPLESVEVNQETFRLLEEENQESLRSLGAW--NLENLRSPEEVDKESQRNLEEEENLGK 925
+ ++ N + R ++E E + ++ ++ L+ + R LE+
Sbjct: 301 SDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDRFASEA 360
Query: 926 GEYQESLRSLEEEGQEL--PQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNL 982
YQ+++ LEEE + L + ++ ++D + L E +E E E+ +NL
Sbjct: 361 SGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGE-ESRINL 418
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 102 bits (254), Expect = 3e-21
Identities = 287/1283 (22%), Positives = 515/1283 (40%), Gaps = 217/1283 (16%)
Query: 25 RVKALEEQNELLSAELGGLRAQSADTSWRAHADDEL-AALRALVDQRWREKHAAEVARDN 83
+++ + + E++ E+ L+ + DT R+ A+ E AA R L K A E +
Sbjct: 793 QIQTVTQAKEVIQGEVRCLKLE-LDTE-RSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
Query: 84 LAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVA 143
+E+ + + ++ R + +E+A+ ++E EK L ++ E + E+EA++
Sbjct: 851 HEKEVNQLREKWEKERSWHQ---QELAKALESLEREKME---LEMRLKEQQTEMEAIQAQ 904
Query: 144 HEEERVGLNAQAACAPRCPAPPRG---------PPAPAPEVEELARRLGEAWRGAVRGYQ 194
EEER + A C + + + RL + + Q
Sbjct: 905 REEERTQAES-ALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ 963
Query: 195 ERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEG------ 248
E ++T L +A+ L A AR+ R +L LQ E LL+ + L++++E
Sbjct: 964 ETTGILQTQLQEAQRELKEA---ARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
Query: 249 -----------RWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSL 297
QE+LR T+++ + LE+EK L ++E Q+L L+ + S+
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL---TLSLMEKEQRLLVLQEADSI 1077
Query: 298 EVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLP 357
+ L A +Q G K LS Q +L Q + E L +L
Sbjct: 1078 R----QQELSALRQDMQEAQGEQK-ELSAQ-MELLRQEVKEKEADFLAQEAQLLEELEAS 1131
Query: 358 SPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPL-SLLQ 416
L + A LQ R + S + P A+ +AQ A L S LQ
Sbjct: 1132 HITEQQLRASLWAQEAKAAQLQLRLRSTES-QLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
Query: 417 TQGGRKQAPEPLRAEARVAIPASVLPGPEEPGG----QRQEASTGQSPEDHASLAPPLSP 472
G P + + P+ P++ G +R T S E AS L
Sbjct: 1191 QALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ 1250
Query: 473 D--------------HSSLEAK--DGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVV 516
D LE + D E+ S+V + + + + Q+ E+++ EGK
Sbjct: 1251 DLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQ-DLQRQLSQNQEEKSKWEGK-Q 1308
Query: 517 SSLQQEIWE--------EEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETL 568
+SL+ E+ E + L R E+Q + E+E L++ E + ++ L+ E
Sbjct: 1309 NSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEA- 1367
Query: 569 ERENQECPRSLEEDLETLKS-LEKENKELLKDVEVVRPLEKEAVGQLK-PTGK---EDTQ 623
R LEEDL T +S L+ +N+E+ + E + L+++ G+LK GK E+
Sbjct: 1368 -RAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQ--GELKVAQGKALQENLA 1424
Query: 624 TLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQE-PLRSPE 682
L E +E +++L G ++ E Q + L SL L+K NQE L+ +
Sbjct: 1425 LLTQTLAEREEEVETLRGQIQEL-----EKQREMQKAALELLSLD-LKKRNQEVDLQQEQ 1478
Query: 683 VGDEEALRPLTKENQEPLRSLEDE---NKEAFRSLEKEN-------QEPLKTLEEEDQSI 732
+ + E R + + ++ E + +E R LEK+ + L LE++DQ I
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538
Query: 733 ------VRPLE-------------TENHKSLR-------------------------SLE 748
V+ L+ ENH + LE
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLE 1598
Query: 749 EQDQE------TLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENE 802
E+ QE + LE + R L E+DQ E++ E L+ + + + LE
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI--EELQRQKEHLTQDLERR 1656
Query: 803 NQE-FLKSLKEESVEAVKSLETEILE--------SLKSAGQENLETLKSPETQAPLWT-P 852
+QE L+ + + +E ++ +T+ILE SL+ G+E + + +A P
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716
Query: 853 EEINQGAMNPL-------EKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRS 905
+ +G++ + EKE++ E + QE LE++ Q R +G +L +
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
Query: 906 PEEVD------KESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQ 959
+E+ +E++ E +E + + E+ R+L + QEL +Q+ + + +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEA---LQQEQQQAQGQE 1833
Query: 960 ELAQESPPGMAGVENEDEAELNLREQDG----------FTGKEEVVEQGELNATEEVWIP 1009
E +E + G ++A + L+E+ G +E VE + A EEV
Sbjct: 1834 ERVKEKADALQGA--LEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVL-- 1889
Query: 1010 GEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPL--- 1066
G+ ES E +++ L+ A + AE Q+ E +++ + LQA L E + L
Sbjct: 1890 GDLRAESRE--QEKALL--ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945
Query: 1067 -VEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLE 1125
E + ++A+ + A+G++ A + G HL + + LE
Sbjct: 1946 RAESQSSRHQEEAARARAEALQEALGKAHAALQ----------GKEQHLLEQAELSRSLE 1995
Query: 1126 EESLEAK-RVQGLEGPRKDLEEA 1147
+ + + + + LEEA
Sbjct: 1996 ASTATLQASLDACQAHSRQLEEA 2018
Score = 80.9 bits (198), Expect = 9e-15
Identities = 229/1070 (21%), Positives = 431/1070 (40%), Gaps = 119/1070 (11%)
Query: 25 RVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAEVARD-N 83
R+ L+E + + EL LR + EL+A L+ Q +EK A +A++
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGE---QKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 84 LAEELEGVAGRCQQLRL---ARERTTEEVARNRRAVEAEKCA---------RAWLSSQVA 131
L EELE QQLR A+E ++ R+ E++ A +A +Q+A
Sbjct: 1124 LLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLA 1183
Query: 132 ELERELEALRVAHEEERVGLNAQAACAPRC-----------PAPPRGPPAPAPEVEELAR 180
L L+ + E R L+ AP RGP A E +A
Sbjct: 1184 SLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVAS 1243
Query: 181 RLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRA 240
L + + + Q R + + + ERL + ELQ LQ + E ++
Sbjct: 1244 ALHKLHQDLWKTQQTRDV-LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Query: 241 ALEQR---LEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSL 297
E + LE E Q + E ++ Q + + ++ L L
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQA 1362
Query: 298 EVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLP 357
V R A L+ ++++L ++ ++E + R + G L V +L
Sbjct: 1363 AVVEARAQASAAGI-LEEDLRTARSALKLKNEEVESERERAQALQEQGEL-KVAQGKALQ 1420
Query: 358 SPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQT 417
L A L + + E L+ + L ++D + R Q+ L Q
Sbjct: 1421 ENL-ALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479
Query: 418 QGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSL 477
Q K +P +V ++ QR++ + +D + L L
Sbjct: 1480 QELEKCR------SVLEHLPMAVQEREQKLTVQREQIR--ELEKDRETQRNVLEHQLLEL 1531
Query: 478 EAKDG--ESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQ 535
E KD ES +V + + + L +E + + L +E+ + + R +
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALT 1591
Query: 536 DSQVPLEKETLKSLGEEIQ-ESLKTLENQSHET-LERENQECPRSLEEDLETLKSLEKEN 593
+ LE+ + +E+Q +S + + +SH T L RE QE + ++ E ++ L+++
Sbjct: 1592 HLTLDLEERS-----QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK 1646
Query: 594 KELLKDVEV-----------VRPLEKEAVGQ--------------LKPTGKEDT---QTL 625
+ L +D+E ++ LE + Q L+ G+E T Q +
Sbjct: 1647 EHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLM 1706
Query: 626 QSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRS--PEV 683
Q +E + K+ G+LE + ++ V QE++ L L+ + ++ L+ +V
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766
Query: 684 GD---------------EEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEE 728
G+ ++ L+ ++ + +SL+ + EA R+L + +QE L+ L++E
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQE-LEALQQE 1825
Query: 729 DQSIVRPLETENHKS--LRSLEEQDQETLRTLEKETQQRR---RSLGEQDQMTLRPPEKV 783
Q E K+ L+ EQ TL+ E Q + R L E+ + R + +
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
Query: 784 D--LEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILES---LKSAGQENLE 838
+ L L++ +E + L Q+ + +E VE ++L+ L++ LK QE LE
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVET-RALQDSWLQAQAVLKERDQE-LE 1943
Query: 839 TLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAW 898
L++ E+Q+ EE + L++ + + +++ ++ LLE+ E RSL A
Sbjct: 1944 ALRA-ESQSSRHQ-EEAARARAEALQEALGKAHAALQGKEQ--HLLEQA--ELSRSLEA- 1996
Query: 899 NLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKD 958
+ L++ + + R LEE + +GE Q+ +E+ Q+L Q+ + E +++
Sbjct: 1997 STATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE 2056
Query: 959 QELAQESPPGMAGVENEDEAELNL---REQDGFTGKEEVVEQGELNATEE 1005
+E E EN + + NL RE++ G + V + +L ++
Sbjct: 2057 REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106
Score = 78.6 bits (192), Expect = 5e-14
Identities = 112/493 (22%), Positives = 213/493 (43%), Gaps = 47/493 (9%)
Query: 507 KETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHE 566
KE +++ ++ + + +++L + + Q ++E +K + +Q +L+ Q+H
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALE----QAHM 1852
Query: 567 TLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQ 626
TL+ + E L++ E + LE+E L + V+ LE E +G L+ +E + L
Sbjct: 1853 TLKERHGE----LQDHKEQARRLEEE---LAVEGRRVQALE-EVLGDLRAESREQEKALL 1904
Query: 627 SLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDE 686
+LQ++ E + E + Q ++ + LE+L A E ++
Sbjct: 1905 ALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA-ESQSSRHQEEAARARA 1963
Query: 687 EALRPLTKENQEPLRSLED---ENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKS 743
EAL+ + L+ E E E RSLE L+ + Q+ R LE ++
Sbjct: 1964 EALQEALGKAHAALQGKEQHLLEQAELSRSLEASTAT-LQASLDACQAHSRQLE----EA 2018
Query: 744 LRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENEN 803
LR E + Q+ +++ QQ +++L ++D+ E+ L KSL Q + + E
Sbjct: 2019 LRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLE-KSLAQRVQENMIQEK 2077
Query: 804 QEFLKSLKEESV----EAVKSL-------ETEILESLKSAGQENLETLKSPETQAPLWTP 852
Q + +EE + ++V+ L E EILE ++ + NLE L +P+
Sbjct: 2078 QNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPM--- 2134
Query: 853 EEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLG---AWNLENLRSPEEV 909
E ++ LE +Q LE ++ E E +E + L A ++ S +EV
Sbjct: 2135 -EEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEV 2193
Query: 910 DKESQRNL---EEEENLGKGEYQESLRSLEEEGQELPQSADV----QRWEDTVEKDQELA 962
Q ++ + E+ + E + + R+LE+E P + R E V+ +
Sbjct: 2194 AMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSG 2253
Query: 963 QESPPGMAGVENE 975
E+ P G+E +
Sbjct: 2254 VEAEPSPDGMEKQ 2266
Score = 69.7 bits (169), Expect = 2e-11
Identities = 239/1039 (23%), Positives = 406/1039 (39%), Gaps = 171/1039 (16%)
Query: 19 LEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAE 78
LE L R + E L AE S++ + + E+A LRA A +
Sbjct: 554 LEGELLRQEQTEVTAALARAEQSIAELSSSENTLKT----EVADLRAA---------AVK 600
Query: 79 VARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELE 138
++ N A L+ V G QQL E +R +EA + AR L +AE E+ E
Sbjct: 601 LSALNEALALDKV-GLNQQLLQLEEENQSVCSR----MEAAEQARNALQVDLAEAEKRRE 655
Query: 139 ALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEV-EELARRLGEAWRGAVRGYQERV 197
AL E+ L AQ A A + E EE+ ++L E+ R QE
Sbjct: 656 ALW----EKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES-----RHQQEAA 706
Query: 198 AHMETSLGQARER----LGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQER 253
L Q +R L RAVQ E+ L+ +AALE RL+ ++R
Sbjct: 707 TTQLEQLHQEAKRQEEVLARAVQ--------------EKEALVREKAALEVRLQAVERDR 752
Query: 254 LRATEKFQLAVEALEQEKQGL-----QSQIAQVLEGR-----QQLAHLKMSLSLEVATYR 303
E+ Q A E + L Q+ + +V +G+ Q + K + EV +
Sbjct: 753 QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLK 812
Query: 304 TLLEAENSRLQTPGGGSKTSL--SFQDPKLELQFPRTPEGRRLGSLLPVLS------PTS 355
L+ E S+ + + L + Q+ K L+ + + + L
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQE 872
Query: 356 LPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLL 415
L L + + ++ +E Q + + QA S ++ + +SLL
Sbjct: 873 LAKALESLEREKMELEMRLKE-QQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLL 931
Query: 416 QT-------QGGRKQAPEPLRAEARV-AIPASVLPGPEEPGGQRQEASTGQSPEDHASLA 467
+T Q E LR + +V + G + Q + ++ H
Sbjct: 932 ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDL 991
Query: 468 PPLSPDHSSL--EAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWE 525
L + SSL + D + + S + + Q LVE+E +Q+++ E
Sbjct: 992 AALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQ--RLVEQE----------VQEKLRE 1039
Query: 526 EEDLNR--KEIQDSQVPLEKETLKSLGEE----IQESLKTLENQSHETLERENQEC---P 576
++ NR KE++ + L TL + +E + + ++ Q L ++ QE
Sbjct: 1040 TQEYNRIQKELEREKASL---TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQ 1096
Query: 577 RSLEEDLETLKS--LEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQE 634
+ L +E L+ EKE L ++ +++ LE + + + Q ++ Q Q
Sbjct: 1097 KELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQL--QL 1154
Query: 635 LMKSLEGNLETFLF---PGTENQ------ELVSSLQENLESLTALEKE-----NQEPLRS 680
++S E LE PG + Q L S+LQ+ L S+ E + P
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVW 1214
Query: 681 PEVGDEEALRPLTKENQEPLRSLEDENKEAFRS-LEKENQEPLKTLEEED--QSIVRPLE 737
D+ R L K PL L + EA S L K +Q+ KT + D + V+ LE
Sbjct: 1215 GLEPDQNGARSLFKRG--PL--LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLE 1270
Query: 738 -----TENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDL-EPLKSL 791
TE KS E QD + R L + +++ + G+Q+ + E ++L E + SL
Sbjct: 1271 ERLTDTEAEKSQVHTELQDLQ--RQLSQNQEEKSKWEGKQNSL---ESELMELHETMASL 1325
Query: 792 DQ-----EIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAG-----QENLET-- 839
E+ R +E L++ KE V+ L+ ++E+ A +E+L T
Sbjct: 1326 QSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTAR 1385
Query: 840 ----LKSPETQAPLWTPEEI-NQGAMNPLE-KEIQEPL-----------ESVEVNQETFR 882
LK+ E ++ + + QG + + K +QE L E VE + +
Sbjct: 1386 SALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQ 1445
Query: 883 LLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQEL 942
LE++ + +L +L+ + +EVD + ++ E E + + L L QE
Sbjct: 1446 ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELE------KCRSVLEHLPMAVQER 1499
Query: 943 PQSADVQRWE-DTVEKDQE 960
Q VQR + +EKD+E
Sbjct: 1500 EQKLTVQREQIRELEKDRE 1518
Score = 67.8 bits (164), Expect = 8e-11
Identities = 189/877 (21%), Positives = 340/877 (38%), Gaps = 121/877 (13%)
Query: 9 SFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVD 68
+ ++ E + ++E +K LE Q E L L + S EL A + +
Sbjct: 1559 ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERS------QELQAQSSQIH 1612
Query: 69 QRWREKHAAEVARD--NLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWL 126
E H+ +AR+ +E++ + ++L+ +E T+++ R + + +K L
Sbjct: 1613 DL--ESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670
Query: 127 SSQVAE----LERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPP-APAPEVEELARR 181
Q LE +LE ++++ E L Q +GP A +E +
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 182 LG------EAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGL 235
L E + + QE +E L ++G + E+ LQ +
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790
Query: 236 LERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSL 295
E+ EQ L+ + E RA + +EAL+QE+Q Q Q +V E L
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG----- 1845
Query: 296 SLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTS 355
+LE A L+ + LQ ++ L+ EGRR+ +L VL
Sbjct: 1846 ALEQA--HMTLKERHGELQ----------DHKEQARRLEEELAVEGRRVQALEEVL---- 1889
Query: 356 LPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLL 415
L A A L Q+ Q A + E+ + S L
Sbjct: 1890 --GDLRAESREQEKALLALQQ------------------QCAEQAQEHEVETRALQDSWL 1929
Query: 416 QTQG---GRKQAPEPLRAEARVA-----IPASVLPGPEEPGGQRQEASTGQSPE--DHAS 465
Q Q R Q E LRAE++ + + +E G+ A G+ + A
Sbjct: 1930 QAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAE 1989
Query: 466 LAPPLSPDHSSLEAK-DGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIW 524
L+ L ++L+A D SR EG+I + + + V LQQ +
Sbjct: 1990 LSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEI----QDQDLRYQEDVQQLQQALA 2045
Query: 525 EEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLE 584
+ ++ R + Q+ + LE KSL + +QE++ ++ + + ERE +E R L + +
Sbjct: 2046 QRDEELRHQ-QEREQLLE----KSLAQRVQENM--IQEKQNLGQEREEEEI-RGLHQSVR 2097
Query: 585 TLK-SLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQ------SLQKENQELMK 637
L+ +L ++ +E+L+ E + EA+ T + Q+L+ LQ+E + L
Sbjct: 2098 ELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA 2157
Query: 638 SLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQ 697
+L + + Q+L SL + S+++L++ L+ E
Sbjct: 2158 ALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAM------------FLQASVLERD 2205
Query: 698 EPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRT 757
+ L+DE + R+LEKE L + L + + ++ E E +
Sbjct: 2206 SEQQRLQDELELTRRALEKER------LHSPGATSTAELGSRGEQGVQLGEVSGVEAEPS 2259
Query: 758 LE-KETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVE 816
+ E Q R+ L Q R ++D L+ + ++ LE +E + LK E++
Sbjct: 2260 PDGMEKQSWRQRLEHLQQAVAR--LEIDRSRLQRHNVQLRSTLEQVERE-RRKLKREAMR 2316
Query: 817 AVKSLETEILESLKSA-------GQENLETLKSPETQ 846
A ++ EI ++ S+ GQ+N + E Q
Sbjct: 2317 AAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQ 2353
Score = 65.9 bits (159), Expect = 3e-10
Identities = 215/1015 (21%), Positives = 381/1015 (37%), Gaps = 121/1015 (11%)
Query: 27 KALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAEVARDNLAE 86
KAL ++ + L+ E L Q+ D L+ VD +E+ + AR+ L +
Sbjct: 431 KALRQRLQKLTGERDTLAGQTVD-------------LQGEVDSLSKERELLQKAREELRQ 477
Query: 87 ELEGVAGRCQQLRLA--------------RERTTEE----VARNRRAVEAEKCARAWLSS 128
+LE + +LR +E EE V R E A S
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSE 537
Query: 129 QVAELERELEALRVAH------EEERVGLNAQAACAPRCPAP-PRGPPAPAPEVEEL--- 178
++EL EAL +H +E+ + A A A + A EV +L
Sbjct: 538 SLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA 597
Query: 179 ---ARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGL 235
L EA G +++ +E R+ A Q +++L + + R L
Sbjct: 598 AVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREAL 657
Query: 236 LERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSL 295
E+ LE +L Q+ A + Q + +++EK+ +Q ++++ ++ L
Sbjct: 658 WEKNTHLEAQL----QKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQL 713
Query: 296 SLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRR-LGSLLPVLSPT 354
E +L K +L + LE++ R+ L L LS
Sbjct: 714 HQEAKRQEEVLARAVQ--------EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA 765
Query: 355 S--LPSPL-PATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAP 411
L S L A + V K Q +Q +T T A + E+R
Sbjct: 766 KELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQA-----------KEVIQGEVRCLK-- 812
Query: 412 LSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLS 471
L+ R QA + A AR A Q + + Q H L
Sbjct: 813 ---LELDTERSQAEQERDAAARQLAQAE----------QEGKTALEQQKAAHEKEVNQLR 859
Query: 472 PDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNR 531
+ + + S+ R + E ++ L E++T +E ++Q + EE
Sbjct: 860 EKWEKERSWHQQELAKALESLEREKMELEM-RLKEQQTEME-----AIQAQREEERTQAE 913
Query: 532 KEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEK 591
+ Q+ EKE + SL E + ++ K L + S + LER Q+ ++ ET L+
Sbjct: 914 SALCQMQLETEKERV-SLLETLLQTQKELADASQQ-LERLRQDMKVQKLKEQETTGILQT 971
Query: 592 ENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGT 651
+ +E ++++ ++ + L+ Q LQK+ ++L L ++
Sbjct: 972 QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQ 1031
Query: 652 ENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAF 711
E QE + QE LE+E + L + E+ L L + + S+ + A
Sbjct: 1032 EVQEKLRETQEYNRIQKELERE-KASLTLSLMEKEQRLLVLQEAD-----SIRQQELSAL 1085
Query: 712 RSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGE 771
R +E Q K L + ++R E + E Q E L QQ R SL
Sbjct: 1086 RQDMQEAQGEQKELSAQ-MELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWA 1144
Query: 772 QD------QMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEI 825
Q+ Q+ LR E LE L + Q + L S ++++ +V E+
Sbjct: 1145 QEAKAAQLQLRLRSTES-QLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPEL 1203
Query: 826 LESLKSAG-----QENLETLKSPETQAPLWT--PEEINQGAMNPLEKEIQEPLESVEVNQ 878
SA + + +S + PL T E A++ L +++ + ++ +V +
Sbjct: 1204 SGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLR 1263
Query: 879 ETFRLLEEE--NQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLE 936
+ + LEE + E+ +S L++L+ ++E + E ++N + E E L
Sbjct: 1264 DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELME-LHETM 1322
Query: 937 EEGQELPQSADVQRWEDTVEKDQELAQESPPGM-AGVENEDEAELNLREQDGFTG 990
Q + A++QR E + ++EL Q + + A VE+ A + R Q G
Sbjct: 1323 ASLQSRLRRAELQRME--AQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAG 1375
Score = 65.1 bits (157), Expect = 5e-10
Identities = 218/1062 (20%), Positives = 408/1062 (38%), Gaps = 151/1062 (14%)
Query: 81 RDNLAEELEGVAGRCQQLRLARE---RTTEEVARNRRAVEAEKCARAWLSSQV-AELERE 136
RD LA + + G L RE + EE+ + +E E AW +V EL+ +
Sbjct: 444 RDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQE----AWRLRRVNVELQLQ 499
Query: 137 LEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGA-VRGYQE 195
++ + EE++ L+ R G A E L EA + + G
Sbjct: 500 GDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELL 559
Query: 196 RVAHMETSLGQARERLGRAVQGAREGRL--ELQQLQAERGGLLERRAALEQRLEGRWQER 253
R E + AR A + E L E+ L+A L AL G Q+
Sbjct: 560 RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL 619
Query: 254 LRATEKFQLA---VEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAEN 310
L+ E+ Q +EA EQ + LQ +A+ + R+ L T LEA+
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKN-----------THLEAQL 668
Query: 311 SRLQTPGGGSKTSL-SFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVP 369
+ + G + L Q+ K E+Q LS + T +
Sbjct: 669 QKAEEAGAELQADLRDIQEEKEEIQ--------------KKLSESRHQQEAATTQLEQLH 714
Query: 370 AFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLR 429
K QE + AR + A + A R + LQ K+ E
Sbjct: 715 QEAKRQEEVLARA-VQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSL 773
Query: 430 AEAR-----VAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGES 484
EA+ + + L + Q +E G+ L D +A+
Sbjct: 774 FEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVR------CLKLELDTERSQAEQERD 827
Query: 485 GGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKE 544
+R + + E EG+ +E++ A K V+ L+++ +E +++E+ + LE+E
Sbjct: 828 AAAR--QLAQAEQEGKT--ALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883
Query: 545 ----------------TLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKS 588
+++ EE + ++ Q E+E +L + + L
Sbjct: 884 KMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELAD 943
Query: 589 LEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLF 648
++ + L +D++V + E+E G L+ +E + L+ +++++ + +L+
Sbjct: 944 ASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQ-------- 995
Query: 649 PGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENK 708
+E S LQ+ ++ L+K+ E L+S V +++ R + +E QE LR ++ N+
Sbjct: 996 -----EESSSLLQDKMD----LQKQ-VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNR 1045
Query: 709 EAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRS 768
+ LE+E +L E++Q ++ E + S+ +Q+ LR +E Q ++
Sbjct: 1046 -IQKELEREKASLTLSLMEKEQRLLVLQEAD------SIRQQELSALRQDMQEAQGEQKE 1098
Query: 769 LGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENEN---QEFLKSLKEESVEA------VK 819
L Q ++ LR K + + ++ LE + Q+ SL + +A ++
Sbjct: 1099 LSAQMEL-LRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLR 1157
Query: 820 SLETEI------------------LESLKSAGQENLETL--KSPE-----TQAP-LWTPE 853
S E+++ L SL SA Q+ L ++ PE AP +W E
Sbjct: 1158 STESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE 1217
Query: 854 EINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKES 913
GA + ++ S E L ++ W + R +V ++
Sbjct: 1218 PDQNGARSLFKRGPLLTALSAEAVASALHKLHQD---------LWKTQQTR---DVLRDQ 1265
Query: 914 QRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQ-RWEDTVEKDQELAQESPPGMAGV 972
+ LEE + E + L++ ++L Q+ + + +WE + E MA +
Sbjct: 1266 VQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASL 1325
Query: 973 ENE-DEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLV-EGAS 1030
++ AEL E G+ E+++ + N T +V E+ G++ E
Sbjct: 1326 QSRLRRAELQRMEAQ---GERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382
Query: 1031 VKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVA 1072
A L++ E +S++ A LQ L A +++++A
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLA 1424
Score = 48.5 bits (114), Expect = 5e-05
Identities = 101/509 (19%), Positives = 206/509 (40%), Gaps = 65/509 (12%)
Query: 506 EKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEK---ETLKSLGEEIQESLKTLEN 562
+K+ K++ +L++ + E + N E+ + + L + E SL + I++ + +
Sbjct: 296 QKQNEDYEKMIKALRETV-EILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVE 354
Query: 563 QSHETLERENQECPRSLEEDLETLKSLEKENKE-LLKDVEVVRPLEKEAVGQLKPTGKED 621
+ + E SLE D + ++ + L V V ++AV L+
Sbjct: 355 EGDNIAQGSGHE--NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGC 412
Query: 622 TQTLQSLQKEN----------QELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALE 671
+ + LQ+++ ++ ++ L G +T + Q V SL + E L+
Sbjct: 413 QEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE---LLQ 469
Query: 672 KENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEED-- 729
K +E + EV ++EA R L + N E L+ + A E++ +E + E +
Sbjct: 470 KAREELRQQLEVLEQEAWR-LRRVNVE----LQLQGDSAQGQKEEQQEELHLAVRERERL 524
Query: 730 QSIVRPLETENHKSLRSL------------------EEQDQETLRTLEKETQQRRRSLGE 771
Q ++ LE + +SL L +EQ + T E S E
Sbjct: 525 QEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSE 584
Query: 772 QDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKS 831
T + L +L++ +A NQ+ L+ L+EE+ +E E ++
Sbjct: 585 NTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ-LEEENQSVCSRMEAA--EQARN 641
Query: 832 AGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQES 891
A Q +L ++ + + LW LE ++Q+ E+ Q R ++EE +E
Sbjct: 642 ALQVDLA--EAEKRREALWEKN-------THLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 892 LRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRW 951
+ L + + ++++ Q +EE L R+++E+ + + A ++
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEEVLA--------RAVQEKEALVREKAALEVR 744
Query: 952 EDTVEKDQELAQESPPGMAGVENEDEAEL 980
VE+D++ E G++ + E+ L
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSL 773
Score = 38.5 bits (88), Expect = 0.053
Identities = 87/345 (25%), Positives = 135/345 (39%), Gaps = 80/345 (23%)
Query: 5 MGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADD---ELA 61
M E+S ++ L RL+ L R++A Q E + + WR A D LA
Sbjct: 2134 MEEQSLKLDSLEPRLQRELERLQAALRQTE------------AREIEWREKAQDLALSLA 2181
Query: 62 ALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKC 121
+A V EVA A LE + ++R +E+ RRA+E E+
Sbjct: 2182 QTKASVSS------LQEVAMFLQASVLERDS--------EQQRLQDELELTRRALEKERL 2227
Query: 122 ARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARR 181
+S R + +++ E G+ A+ P+P+ E
Sbjct: 2228 HSPGATSTAELGSRGEQGVQLG---EVSGVEAE----------------PSPDGME---- 2264
Query: 182 LGEAWRGAVRGYQERVAHMETSLGQARERLGR--------AVQGAREGR-LELQQLQAER 232
++WR + Q+ VA +E R RL R Q RE R L+ + ++A +
Sbjct: 2265 -KQSWRQRLEHLQQAVARLEID----RSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQ 2319
Query: 233 GGLLE---RRAALEQRLEGRWQERLRATEKFQLAVEA------LEQEKQGLQSQIAQVLE 283
G LE A+ + +GR Q+ A +L E L E++ Q I + +
Sbjct: 2320 AGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQ 2379
Query: 284 GRQQLAHLKMSLS-----LEVATYRTLLEAENSRLQTPGGGSKTS 323
++LA L SLS + A T+LEAE RL S TS
Sbjct: 2380 TSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTS 2424
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 100 bits (250), Expect = 9e-21
Identities = 127/546 (23%), Positives = 231/546 (42%), Gaps = 52/546 (9%)
Query: 506 EKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSH 565
EKE V+ ++++ EEE ++E+Q+ + L K + L E QE + +
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Query: 566 ETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTL 625
E R QE R +++ + +E +E ++ ++ R E+ QL+ +E+ +
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE- 361
Query: 626 QSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKE---NQEPLRSPE 682
Q L++E +E + + E L Q+L Q E E++ Q+ R +
Sbjct: 362 QQLRREQEEERREQQLRREQQL---RREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 418
Query: 683 VGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEED--------QSIVR 734
+ E+ LR +E + + ++ ++ + ++E ++ LK EE + Q + R
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Query: 735 PLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQE 794
E E + LEE+++ + +E Q RR ++Q R E+ L+ +Q+
Sbjct: 479 DQEEERRERWLKLEEEERREQQE-RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ 537
Query: 795 IARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENL--ETLKSPETQAPLWTP 852
+ R E ++ LK +E K LE E E QE + LK E +
Sbjct: 538 LRREQEERREQLLKREEE------KRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 853 EEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKE 912
E + L++E E LE E ++ RL EE +E R + L EE ++
Sbjct: 592 REQEERLEQRLKREEVERLEQEERREQ--RLKREEPEEERR-------QQLLKSEEQEER 642
Query: 913 SQRNLEEEENLGKGEYQESLRSLEEEGQELPQ-----SADVQRWEDTVEKDQELAQES-- 965
Q+ L E+ E +E EEE + L Q + +R ++ E++QE A+E
Sbjct: 643 RQQQLRREQQ----ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 966 ---PPGMAGVENEDEAELNL-----REQDGFTGKEEVVEQGELNATEEVWIPGEGHPESP 1017
P +E+E +A + R+Q+G ++E E+ +E W E
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 1018 EPKEQR 1023
+ +EQR
Sbjct: 759 QEEEQR 764
Score = 79.3 bits (194), Expect = 3e-14
Identities = 225/1030 (21%), Positives = 383/1030 (37%), Gaps = 124/1030 (12%)
Query: 7 EESFQMWELNRRLEAYLARVKALEEQNEL-----LSAELGGLRAQSADTSWRAHADDELA 61
E+ + E R E L R + L + +L L E R Q + + +L
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 62 ALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKC 121
R ++R +KH E L E E ++ L RE TE + RR + ++
Sbjct: 427 --REQEEERHEQKHEQERREQRLKREQEE-----RRDWLKREEETERHEQERRKQQLKRD 479
Query: 122 ARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARR 181
E ER L++ EE R + R R E EE R
Sbjct: 480 Q---------EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE---R 527
Query: 182 LGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAA 241
L + R + +E+ E L + E+ R Q RE RL+ +Q + R LL+R
Sbjct: 528 LQQRLRSEQQLRREQEERREQLLKREEEK--RLEQERREQRLKREQ-EERRDQLLKREEE 584
Query: 242 L-EQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVA 300
+QRL+ +ERL K + VE LEQE++ Q + E ++ LK E
Sbjct: 585 RRQQRLKREQEERLEQRLKRE-EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643
Query: 301 TYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPL 360
+ E + R Q + ++ +LE + R E R L
Sbjct: 644 QQQLRREQQERREQ------RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE-- 695
Query: 361 PATLETPVPAFLKNQEF-LQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQG 419
+++ +P + E AR + S P Q + + R +++ L + +
Sbjct: 696 --RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 420 GRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHS-SLE 478
+Q E E R + Q Q + S PPL L
Sbjct: 754 AHRQQQEE---EQR-----------RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLR 799
Query: 479 AKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQ 538
A++ + R F E E + E+E + Q + EEE L R+E + Q
Sbjct: 800 AEERQQREQR-FLPEEEEKEQRRRQRREREKEL---------QFLEEEEQLQRRE-RAQQ 848
Query: 539 VPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLK 598
+ E++ L+ E + + + + LE E + +L + L KE + L +
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 599 DVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVS 658
+ E ++ E+E K Q + +E ++L QE
Sbjct: 909 EEEELQREERE---------KRRRQEQERQYREEEQL-----------------QQEEEQ 942
Query: 659 SLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKEN 718
L+E E E+E Q EE L +EP + E ++ +R E+
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLL-----GEEPEKRRRQEREKKYREEEELQ 997
Query: 719 QEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLR--TLEKETQQRRRSLGEQDQMT 776
QE + L EE + R ++ L++++++ LR ++ Q+R R E++++
Sbjct: 998 QEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQ 1057
Query: 777 LRPPEKVDLEPLKSLDQEIARPL--ENENQEFLKSLKEESVEAVKSLETEILESLKSAGQ 834
+ + E QE+ R E E Q+ + L E E + E E + +
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE-----RQCRE 1112
Query: 835 ENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRS 894
E E L+ E Q EE + LE++ + E EV QE +LL EE ++ R
Sbjct: 1113 E--EELQQEEEQL---LREEREKRRRQELERQYR---EEEEVQQEEEQLLREEPEKRRRQ 1164
Query: 895 LGAWNLE-NLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWED 953
LE R EE+ +E ++ L EE+ + E + R E +EL + QR+ D
Sbjct: 1165 ----ELERQYREEEELQQEEEQLLREEQEKRRQERERQYR----EEEELQRQKRKQRYRD 1216
Query: 954 TVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGH 1013
++ +L + P +++ RE + F E+ + + + + GE
Sbjct: 1217 E-DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 1014 PESPEPKEQR 1023
E + +R
Sbjct: 1276 ERDREQERRR 1285
Score = 77.4 bits (189), Expect = 1e-13
Identities = 233/1082 (21%), Positives = 392/1082 (36%), Gaps = 133/1082 (12%)
Query: 1 MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELL--SAELGGLRAQSADTSWRAHADD 58
+E + E + E R E L R + EE+ + L S E R Q + +
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 59 ELAALRA--LVDQRWREKHAAEVARDNLAEE-------------------LEGVAGRCQQ 97
L ++QR + +H E LAEE LE A Q
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 98 LRLARERTTE--------EVARNRRAVEAE--KCARAWLSSQVAELERELEALRVAHEEE 147
+R R E E R RR E + + RA Q E R+ A E+
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 148 RVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQA 207
G +A P R A + E R L E R Q R E +
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQRE-QRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 208 RERLGRAVQGAREGRLELQQLQAERGGLLE---RRAALEQRLEGRWQERLRATEKFQ--- 261
E+L R R QQLQ E GL E RR + EQR + +W+ +L K +
Sbjct: 837 EEQLQR--------RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Query: 262 -LAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGS 320
A AL+++ + Q + + E Q+ K + YR E +LQ
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR-----EEEQLQQ----E 939
Query: 321 KTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQA 380
+ L ++ + + R + R+ L P + + + +E Q
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999
Query: 381 RTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPE---PLRAEARVAIP 437
L Q + Q LL+ + +++ E R E +
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 438 ASVLPGPEEPGGQRQEASTG-------QSPEDHASLAPPLSPDHSSLE--AKDGESGGSR 488
L G E +RQE Q E+ P E ++ E
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE 1119
Query: 489 VFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEE------EDLNRKEIQDSQVPLE 542
+ R E E + +E++ E +V +Q + EE ++L R+ ++ ++ E
Sbjct: 1120 EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE 1179
Query: 543 KETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLK-SLEKENKELLKDVE 601
+E L +E + + + + E L+R+ ++ E+ LK E E + ++D +
Sbjct: 1180 EEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Query: 602 V-VRPLEKEAVGQLKPTGKEDTQTLQSLQK---ENQELMKSLEGNL---------ETFLF 648
V + E E QL+ + D Q+ Q LQ E QE + E E
Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299
Query: 649 PGTENQELVSSLQENLESLTALEKENQEPLRSPEVG----DEEALRPLTKENQEPLRSLE 704
E +E +++ E L +E +E R E +EE L L + ++PLR E
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQL--LQEREEQPLRRQE 1357
Query: 705 DENKEAFRSLEKENQEPLKTLEEEDQSIVRP------LETENHKSLRSLEEQ-DQETLRT 757
+ K FR E +QE + EE+Q + R L+ E + E+Q Q+ R
Sbjct: 1358 RDRK--FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 758 LEKETQQ-----RRRSLGEQDQMTLRPP-EKVDLEPLKSLDQEIARPLENENQEFLKSLK 811
+E QQ R R E++Q R E+ LE + L QE R E Q L+ +
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ-LLQERE 1474
Query: 812 EESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPL 871
E+ + + + E + QE + E ++ E++ E
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS-------------QEPERKFLEEE 1521
Query: 872 ESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGE---- 927
+ + Q + L+EE Q + G ++ R + ++E R EE+ L + E
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQD-RDRKFREEEQLRQEREEQQLSRQERDRK 1580
Query: 928 ---YQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLRE 984
++ +R E+E + + ++R E + QE ++ ++ +E +L+ +E
Sbjct: 1581 FRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE 1640
Query: 985 QD 986
+D
Sbjct: 1641 RD 1642
Score = 69.3 bits (168), Expect = 3e-11
Identities = 117/510 (22%), Positives = 215/510 (42%), Gaps = 84/510 (16%)
Query: 520 QQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPR-- 577
+++ EEE+L ++E Q + EK + L + +E + Q E L RE E R
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEV--QQEEEQLLREEPEKRRRQ 1164
Query: 578 SLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMK 637
LE + L++E ++LL++ + R E+E + +E+ Q + Q+ E +
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERER----QYREEEELQRQKRKQRYRDEDQR 1220
Query: 638 SLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEA---LRPLTK 694
S +L+ P EN ++++N E E L ++ D ++ L+ L
Sbjct: 1221 S---DLKWQWEPEKEN-----AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 695 ENQEPLRSLE-------------------DENKEAFRSLEKENQEPLKTLEEEDQSIVRP 735
E QE R E +E KEA R ++++QE + L EE + R
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR-DRKSQEEKQLLREEREEKRRR 1331
Query: 736 LETEN--HKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQ 793
ET+ + + L+E++++ LR E++ + R L Q+Q K L++
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ------------GRKFLEE 1379
Query: 794 EIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPE 853
E + L + +E K LKEE + E ++ + +E + L E E
Sbjct: 1380 E--QRLRRQERE-RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF--RE 1434
Query: 854 EINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKE- 912
E Q E++ E E ++ QE R EE Q L R +++ ++
Sbjct: 1435 EEQQVRRQERERKFLE--EEQQLRQERHRKFREEEQ----------LLQEREEQQLHRQE 1482
Query: 913 -SQRNLEEEENLGKGE-----YQESLRSLEEEGQELPQSADV---QRWEDTVEKDQELAQ 963
++ LEEE+ L + E ++ LRS E E + L + + QR ++++Q+L +
Sbjct: 1483 RDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRR 1542
Query: 964 ESPPGMAGVENEDEAELNLREQDGFTGKEE 993
+ G + + + RE++ + E
Sbjct: 1543 QE----RGQQRRQDRDRKFREEEQLRQERE 1568
Score = 59.3 bits (142), Expect = 3e-08
Identities = 132/620 (21%), Positives = 246/620 (39%), Gaps = 73/620 (11%)
Query: 512 EGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERE 571
E K ++ EE+ L R+E ++ + +ET + EE ++ L+ E Q ER+
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKR--RRQETDRKFREE-EQLLQEREEQPLRRQERD 1359
Query: 572 ---------NQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTG---- 618
+QE R E+ + L+ E+E K LK+ + +R E+E QL+
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERK-FLKEEQQLRCQEREQ--QLRQDRDRKF 1416
Query: 619 KEDTQTLQSLQKENQ--ELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQE 676
+E+ Q L +++ + E + + F E Q ++ E L++ ++
Sbjct: 1417 REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQ 1476
Query: 677 PLRSPE-----VGDEEALRPLTKEN---QEPLRSLEDENKEAFRSLEKENQEPLKTLEEE 728
L E + +E+ LR ++ ++ LRS E E K + Q+ + +E
Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQE 1536
Query: 729 DQSIVRPLETENHKSLRSLEEQDQETLRTLEKE----TQQRRRSLGEQDQMTLRPPEKVD 784
+Q + R + + R + +++E LR +E Q+R R ++Q R ++
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 785 L----------EPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQ 834
E + L QE R E+++ L+ +E+ + + + E + Q
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKF-REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 835 ENLETLKSPETQAPLWTPEEINQGAMNPL-----EKEIQEPLESVEVNQETFRLLEEENQ 889
E + L+ + + + +G L +++ +E + + + + L+EE Q
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 890 ESLRSLGAWNLENLRSPEEVDKESQRNLE------EEENL---------------GKGEY 928
+ L E + +E ++E R E EEE L K
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 929 QESLRSLEEEGQELPQSADVQ-RWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDG 987
+E LR EE Q Q +D + R E+ + +++E Q P G +E +L L EQ+
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 988 FTGKE--EVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQS 1045
+E E AT+E E E +++R E + Q E +
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRH 1895
Query: 1046 QQVGAPGLQAPQGLPEAIEP 1065
+QVG Q +G +EP
Sbjct: 1896 RQVGEIKSQEGKGHGRLLEP 1915
Score = 41.6 bits (96), Expect = 0.006
Identities = 64/274 (23%), Positives = 102/274 (37%), Gaps = 25/274 (9%)
Query: 25 RVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAEVARDNL 84
R K E++ EL E + + + R D+EL R Q W+E+
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQR----QEWQEREERRAEE--- 190
Query: 85 AEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAH 144
E+L+ G + E EE R R +E + R Q RE +
Sbjct: 191 -EQLQSCKGHETE-----EFPDEEQLRRRELLELRRKGREEKQQQ----RRERQDRVFQE 240
Query: 145 EEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSL 204
EEE+ + P E++E +L + R +R ++
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEE------ 294
Query: 205 GQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAV 264
Q ++RL R Q R+ E ++ Q ER ERR E+R E + + + QL
Sbjct: 295 -QQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRR 353
Query: 265 EALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLE 298
E E+E++ Q + Q E R+Q + L E
Sbjct: 354 EQ-EEERREQQLRREQEEERREQQLRREQQLRRE 386
Score = 35.8 bits (81), Expect = 0.35
Identities = 58/264 (21%), Positives = 110/264 (41%), Gaps = 19/264 (7%)
Query: 57 DDELAALRALVDQRWREKHAAEVAR----DNLAEELEGVAGRCQQ--LRLARERTTEEVA 110
D+E R L++ R + + + R D + +E E R ++ LR E+ EE
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 111 RNRRAVEAEKCARAWLSSQVAELER-ELEALRVAHEEERVGLNAQAACAPRCPAPPRGPP 169
+ +R ++ E+ Q+ +LER EL R E+++ L + + R
Sbjct: 266 QRQRELQEEE-------EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318
Query: 170 APAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQ 229
E +E + E +R QE + Q ER + ++ +E QQL+
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 230 AERGGLLERRAALEQRL----EGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGR 285
E+ E++ EQ+L + R +++LR ++ + + L +E+Q + Q + E +
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLR-REQQLRREQQLRREQEEERHEQK 437
Query: 286 QQLAHLKMSLSLEVATYRTLLEAE 309
+ + L E R L+ E
Sbjct: 438 HEQERREQRLKREQEERRDWLKRE 461
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 96.3 bits (238), Expect = 2e-19
Identities = 124/494 (25%), Positives = 231/494 (46%), Gaps = 85/494 (17%)
Query: 504 LVEKETAIEGKVVSSLQQEI---WEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKT- 559
L+E+ +E S+ + + WE E ++R L + KSLG E+ E +
Sbjct: 408 LMEENMTLEMAQKQSMDESLHLGWELEQISRTS------ELSEAPQKSLGHEVNELTSSR 461
Query: 560 -----LENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQL 614
+ENQS E + S+E + + +EKEN+ L K VE+ LE E V
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI---LENEIV--- 515
Query: 615 KPTGKEDTQTLQSLQKENQELMK---SLEGNLETFLFPGTENQELVSSLQENLESLTALE 671
++ Q+LQ+ Q +++LMK LE +ET +++ E+L +
Sbjct: 516 -----QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 672 KENQEPLRSPEVGDEE----ALRPLTKENQEPLRSLEDENKEAFRSLE--KENQEPLKTL 725
++ + V D E L KE L +E E ++ + LE KE E + L
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 726 EEEDQSIVRPLETENH-------------KSLRSLEEQDQETLRTLEKETQQRRRSLGEQ 772
E E + LE EN + + +LE+++ E LE+E ++ +++L
Sbjct: 631 ENE----LHHLEKENELLQKKITNLKITCEKIEALEQENSE----LERENRKLKKTLDSF 682
Query: 773 DQMTLRPPEKVDLEPLKSLDQEIARPLENENQEF---LKSLKEESVE-AVKSLETEILES 828
+T + L+SL++E ++ L+ EN E ++SLK S++ A LE + LES
Sbjct: 683 KNLTFQ---------LESLEKENSQ-LDEENLELRRNVESLKCASMKMAQLQLENKELES 732
Query: 829 LKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLES----VEVNQETFRLL 884
K ++ LE LK+ + E++ ++ + +Q+ LE+ ++ + + L
Sbjct: 733 EKEQLKKGLELLKASFKKTERL---EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 885 EEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQ 944
E ENQ ++L + + R E+++KE+ ++LE+E + + ++ + LE+E + L Q
Sbjct: 790 EMENQTLQKNLEELKISSKRL-EQLEKEN-KSLEQETS----QLEKDKKQLEKENKRLRQ 843
Query: 945 SADVQRWEDTVEKD 958
A+++ + T+E++
Sbjct: 844 QAEIK--DTTLEEN 855
Score = 79.3 bits (194), Expect = 3e-14
Identities = 119/481 (24%), Positives = 205/481 (42%), Gaps = 94/481 (19%)
Query: 533 EIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKE 592
E+QD + +E +TL+ EE++ S K LE LE+EN+ + + + K LEKE
Sbjct: 785 ELQDLE--MENQTLQKNLEELKISSKRLEQ-----LEKENKSLEQETSQLEKDKKQLEKE 837
Query: 593 NKELLKDVEV-----------VRPLEKEAVGQLKPTG--KEDTQTLQSLQKENQELMKSL 639
NK L + E+ + LEKE K G KE L+ L+KEN+EL+K
Sbjct: 838 NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897
Query: 640 EGNLETFLFPGTENQELVS------SLQENLESLT-ALEK---ENQEPLRSPEVGDEEAL 689
+++T + T ++LVS + +LE LT LEK + L + D+
Sbjct: 898 TIDIKTLV---TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRY 954
Query: 690 RPLTKENQEPLRSLEDENKEAFRSLE--------------------KENQEPLKTLEEED 729
+ L + + L+ + +E +LE K+N E LK ++E+
Sbjct: 955 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Query: 730 QSIVR--PLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEP 787
+ + P+ E++K R +E +E L+ ++ + E++ TL+ ++
Sbjct: 1015 RMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV------ERNNATLQAEKQALKTQ 1068
Query: 788 LKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQA 847
LK L+ + N Q + +L+ ++V + T L++ + Q TL S T
Sbjct: 1069 LKQLETQ-----NNNLQAQILALQRQTVSLQEQNTT--LQTQNAKLQVENSTLNSQSTSL 1121
Query: 848 PLWTPEEINQGAMNPLEK-EIQEPLESVEVNQETFRLL------EEENQESLRSLGAWNL 900
+NQ A +++ ++ ESV +E + L + E E L A
Sbjct: 1122 -------MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY 1174
Query: 901 ENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEE-GQELPQSADVQRWEDTVEKDQ 959
E+L S K + +NLE E R LE+ Q L Q ++ E ++ +Q
Sbjct: 1175 ESLISKHGTLKSAHKNLEVEH-----------RDLEDRYNQLLKQKGQLEDLEKMLKVEQ 1223
Query: 960 E 960
E
Sbjct: 1224 E 1224
Score = 60.8 bits (146), Expect = 1e-08
Identities = 118/519 (22%), Positives = 212/519 (40%), Gaps = 112/519 (21%)
Query: 544 ETLKSLGEEIQESLKTLENQSHETLERENQ--ECPRSLEEDLETLKSLEKENKELLKDVE 601
E+ + L E+ ++ + E E+ Q +C + LE+ LK L++EN LL D
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 602 VVRPLEKEAVGQLKPTGKED-------------------TQTLQSLQKENQELMKS---L 639
R E + + D ++ L+++NQ L+++ L
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 640 EGNLETFLFPGT------------ENQELVSSL--------------QENLESLTALEKE 673
E LE GT EN +L + L +E +E LE
Sbjct: 364 EDQLE-----GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 674 NQEPL-RSPEVGDE-EALRPLTKENQEPLRSLEDENKEAFRS----LEKENQEPLKTLE- 726
++ + S +G E E + ++ ++ P +SL E E S LE ENQ KT+E
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 727 --------EEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLR 778
E + S + +E EN + + +E + E ++ EK++ Q ++L +D M +
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ--EKQSLQNCQNL-SKDLMKEK 535
Query: 779 PPEKVDLEPLKSLDQEIARPLENENQEF------LKSLKEESVEA-VKSLETE---ILES 828
+ +E L+ + + LE EN+ L+ + S EA VK +E E + ES
Sbjct: 536 AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 829 LKSAGQ-------ENLETLKSPETQAPLWTPEEINQGAMNPLEKE---IQEPLESVEVNQ 878
+K E + K E E + ++ LEKE +Q+ + ++++
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 879 ETFRLLEEENQESLRSLGAWNLENLRSPEEVDK-----------ESQRNLEEEENLGKGE 927
E LE+EN E R EN + + +D E + + +EENL
Sbjct: 656 EKIEALEQENSELER-------ENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR 708
Query: 928 YQESLRSLEEEGQELP-QSADVQRWEDTVEKDQELAQES 965
ESL+ + +L ++ +++ ++ ++K EL + S
Sbjct: 709 NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
Score = 46.6 bits (109), Expect = 2e-04
Identities = 125/615 (20%), Positives = 233/615 (37%), Gaps = 108/615 (17%)
Query: 195 ERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERL 254
E++ H +G +ERL Q + R +L LE +LE ++ L
Sbjct: 926 EKLTHELEKIGLNKERLLHDEQSTDDSRYKL----------------LESKLESTLKKSL 969
Query: 255 RATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQ 314
E+ A+EA +E Q+ RQ+L +K + Y L + ++
Sbjct: 970 EIKEEKIAALEARLEESTNYNQQL------RQELKTVKKN-------YEALKQRQDEERM 1016
Query: 315 TPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKN 374
S +S +D K E + T LL V ATL+ A
Sbjct: 1017 VQ---SSPPISGEDNKWERESQETTR-----ELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
Query: 375 QEFLQARTPTLASTPIPPTPQAPS-PAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEAR 433
+ L+ + L + + Q S + ++ Q+A L + + Q+ + A+
Sbjct: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV-ENSTLNSQSTSLMNQNAQ 1127
Query: 434 VAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSIC 493
+ I S L E S + ED SL L DH LE +
Sbjct: 1128 LLIQQSSLENENE--------SVIKEREDLKSLYDSLIKDHEKLE-------------LL 1166
Query: 494 RGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGE-- 551
+ L+ K G + S+ + E DL E + +Q+ +K L+ L +
Sbjct: 1167 HERQASEYESLISKH----GTLKSAHKNLEVEHRDL---EDRYNQLLKQKGQLEDLEKML 1219
Query: 552 EIQESLKTLENQSHETLERENQE-CPRS---------LEEDLETLKSLEKENKELLKDVE 601
++++ LEN++HET+ E ++ C + L ++ E L++ K K LL + +
Sbjct: 1220 KVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK 1279
Query: 602 VVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQ-ELMKSLEGNLETFLFPGTENQELVSSL 660
+ + + +LK ++ + S + NQ EL+ L+GNLE EN+ L+ +
Sbjct: 1280 LEQTRLEAEFSKLKEQYQQ--LDITSTKLNNQCELLSQLKGNLE------EENRHLLDQI 1331
Query: 661 Q-----------ENLESLTALEKENQEPL-------RSPEVGDEEALRPLTKENQEPLRS 702
Q +N+ES E ++ + R E +E+ + + P R
Sbjct: 1332 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRR 1391
Query: 703 LEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKET 762
+ R L K ++ + E + + P +++ + L QD + ++ +
Sbjct: 1392 RGNWITLKMRKLIKSKKDINR--ERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNS 1449
Query: 763 QQRRRSLGEQDQMTL 777
+ ++LG + T+
Sbjct: 1450 LEDGQTLGTKKSSTM 1464
Score = 39.3 bits (90), Expect = 0.031
Identities = 66/315 (20%), Positives = 137/315 (43%), Gaps = 27/315 (8%)
Query: 19 LEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAE 78
+E Y ARV+ L+E N++L L Q T R+ D+L L Q + H E
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS---DKLHELEKENLQLKAKLHDME 395
Query: 79 VARDNLAEELEGVAGRCQQLRLARERT----------TEEVARNRRAVEAEKCA-----R 123
+ RD +++E + L +A++++ E+++R EA + +
Sbjct: 396 MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455
Query: 124 AWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLG 183
SS++ +LE E ++L EE R +++ A + + + +VE L +
Sbjct: 456 ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
Query: 184 EAWRGAVRGYQERVAHMETSLGQARERLGRAVQGARE-GRLELQQLQAERGGLLERRAAL 242
+ + + ++ L + + +L + ++ RE +++ L+ E L + ++L
Sbjct: 516 QEKQSL-----QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 243 EQRLEGRWQERLRATEK-FQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKM--SLSLEV 299
QR + + R++ EK ++ E++++ L + + +++L H K + E+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 300 ATYRTLLEAENSRLQ 314
LE EN LQ
Sbjct: 631 ENELHHLEKENELLQ 645
Score = 36.6 bits (83), Expect = 0.20
Identities = 59/286 (20%), Positives = 116/286 (40%), Gaps = 39/286 (13%)
Query: 25 RVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAEVARDN- 83
++K LE++NE L+ + LR +S ++ E ++ ++N
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISA---------------------EARVKDIEKENK 590
Query: 84 -LAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRV 142
L E ++ + + ++ + + +E+ + EK RA ELE EL L
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYK-----EKGERA------EELENELHHLEK 639
Query: 143 AHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMET 202
+E + + + A + E +L + L ++++ +Q E
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL-DSFKNLT--FQLESLEKEN 696
Query: 203 S-LGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQ 261
S L + L R V+ + +++ QLQ E L + L++ LE + + TE+ +
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE-LLKASFKKTERLE 755
Query: 262 LAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLE 307
++ + L+ E Q LQ + + QQL L +E T + LE
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 96.3 bits (238), Expect = 2e-19
Identities = 124/494 (25%), Positives = 231/494 (46%), Gaps = 85/494 (17%)
Query: 504 LVEKETAIEGKVVSSLQQEI---WEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKT- 559
L+E+ +E S+ + + WE E ++R L + KSLG E+ E +
Sbjct: 408 LMEENMTLEMAQKQSMDESLHLGWELEQISRTS------ELSEAPQKSLGHEVNELTSSR 461
Query: 560 -----LENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQL 614
+ENQS E + S+E + + +EKEN+ L K VE+ LE E V
Sbjct: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEI---LENEIV--- 515
Query: 615 KPTGKEDTQTLQSLQKENQELMK---SLEGNLETFLFPGTENQELVSSLQENLESLTALE 671
++ Q+LQ+ Q +++LMK LE +ET +++ E+L +
Sbjct: 516 -----QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 672 KENQEPLRSPEVGDEE----ALRPLTKENQEPLRSLEDENKEAFRSLE--KENQEPLKTL 725
++ + V D E L KE L +E E ++ + LE KE E + L
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 726 EEEDQSIVRPLETENH-------------KSLRSLEEQDQETLRTLEKETQQRRRSLGEQ 772
E E + LE EN + + +LE+++ E LE+E ++ +++L
Sbjct: 631 ENE----LHHLEKENELLQKKITNLKITCEKIEALEQENSE----LERENRKLKKTLDSF 682
Query: 773 DQMTLRPPEKVDLEPLKSLDQEIARPLENENQEF---LKSLKEESVE-AVKSLETEILES 828
+T + L+SL++E ++ L+ EN E ++SLK S++ A LE + LES
Sbjct: 683 KNLTFQ---------LESLEKENSQ-LDEENLELRRNVESLKCASMKMAQLQLENKELES 732
Query: 829 LKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLES----VEVNQETFRLL 884
K ++ LE LK+ + E++ ++ + +Q+ LE+ ++ + + L
Sbjct: 733 EKEQLKKGLELLKASFKKTERL---EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 885 EEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQ 944
E ENQ ++L + + R E+++KE+ ++LE+E + + ++ + LE+E + L Q
Sbjct: 790 EMENQTLQKNLEELKISSKRL-EQLEKEN-KSLEQETS----QLEKDKKQLEKENKRLRQ 843
Query: 945 SADVQRWEDTVEKD 958
A+++ + T+E++
Sbjct: 844 QAEIK--DTTLEEN 855
Score = 81.6 bits (200), Expect = 6e-15
Identities = 121/480 (25%), Positives = 207/480 (43%), Gaps = 93/480 (19%)
Query: 533 EIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKE 592
E+QD + +E +TL+ EE++ S K LE LE+EN+ + + + K LEKE
Sbjct: 785 ELQDLE--MENQTLQKNLEELKISSKRLEQ-----LEKENKSLEQETSQLEKDKKQLEKE 837
Query: 593 NKELLKDVEV-----------VRPLEKEAVGQLKPTG--KEDTQTLQSLQKENQELMKSL 639
NK L + E+ + LEKE K G KE L+ L+KEN+EL+K
Sbjct: 838 NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRA 897
Query: 640 EGNLETFLFPGTENQELVS------SLQENLESLT-ALEK--ENQEPLRSPEVGDEEALR 690
+++T + T ++LVS + +LE LT LEK N+E L E ++ +
Sbjct: 898 TIDIKTLV---TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYK 954
Query: 691 PLTKENQEPLRSLEDENKEAFRSLE--------------------KENQEPLKTLEEEDQ 730
L + + L+ + +E +LE K+N E LK ++E++
Sbjct: 955 LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014
Query: 731 SIVR--PLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPL 788
+ P+ E++K R +E +E L+ ++ + E++ TL+ ++ L
Sbjct: 1015 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV------ERNNATLQAEKQALKTQL 1068
Query: 789 KSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAP 848
K L+ + N Q + +L+ ++V + T L++ + Q TL S T
Sbjct: 1069 KQLETQ-----NNNLQAQILALQRQTVSLQEQNTT--LQTQNAKLQVENSTLNSQSTSL- 1120
Query: 849 LWTPEEINQGAMNPLEK-EIQEPLESVEVNQETFRLL------EEENQESLRSLGAWNLE 901
+NQ A +++ ++ ESV +E + L + E E L A E
Sbjct: 1121 ------MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174
Query: 902 NLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEE-GQELPQSADVQRWEDTVEKDQE 960
+L S K + +NLE E R LE+ Q L Q ++ E ++ +QE
Sbjct: 1175 SLISKHGTLKSAHKNLEVEH-----------RDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1223
Score = 60.8 bits (146), Expect = 1e-08
Identities = 118/519 (22%), Positives = 212/519 (40%), Gaps = 112/519 (21%)
Query: 544 ETLKSLGEEIQESLKTLENQSHETLERENQ--ECPRSLEEDLETLKSLEKENKELLKDVE 601
E+ + L E+ ++ + E E+ Q +C + LE+ LK L++EN LL D
Sbjct: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDAR 303
Query: 602 VVRPLEKEAVGQLKPTGKED-------------------TQTLQSLQKENQELMKS---L 639
R E + + D ++ L+++NQ L+++ L
Sbjct: 304 SARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 640 EGNLETFLFPGT------------ENQELVSSL--------------QENLESLTALEKE 673
E LE GT EN +L + L +E +E LE
Sbjct: 364 EDQLE-----GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 674 NQEPL-RSPEVGDE-EALRPLTKENQEPLRSLEDENKEAFRS----LEKENQEPLKTLE- 726
++ + S +G E E + ++ ++ P +SL E E S LE ENQ KT+E
Sbjct: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
Query: 727 --------EEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLR 778
E + S + +E EN + + +E + E ++ EK++ Q ++L +D M +
Sbjct: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ--EKQSLQNCQNL-SKDLMKEK 535
Query: 779 PPEKVDLEPLKSLDQEIARPLENENQEF------LKSLKEESVEA-VKSLETE---ILES 828
+ +E L+ + + LE EN+ L+ + S EA VK +E E + ES
Sbjct: 536 AQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES 595
Query: 829 LKSAGQ-------ENLETLKSPETQAPLWTPEEINQGAMNPLEKE---IQEPLESVEVNQ 878
+K E + K E E + ++ LEKE +Q+ + ++++
Sbjct: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC 655
Query: 879 ETFRLLEEENQESLRSLGAWNLENLRSPEEVDK-----------ESQRNLEEEENLGKGE 927
E LE+EN E R EN + + +D E + + +EENL
Sbjct: 656 EKIEALEQENSELER-------ENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR 708
Query: 928 YQESLRSLEEEGQELP-QSADVQRWEDTVEKDQELAQES 965
ESL+ + +L ++ +++ ++ ++K EL + S
Sbjct: 709 NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
Score = 45.4 bits (106), Expect = 4e-04
Identities = 129/634 (20%), Positives = 244/634 (38%), Gaps = 104/634 (16%)
Query: 237 ERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLS 296
+R LE +LE ++ L E+ A+EA +E Q+ RQ+L +K +
Sbjct: 951 DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL------RQELKTVKKN-- 1002
Query: 297 LEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSL 356
Y L + ++ S +S +D K E + T LL V
Sbjct: 1003 -----YEALKQRQDEERMVQ---SSPPISGEDNKWERESQETTR-----ELLKVKDRLIE 1049
Query: 357 PSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPS-PAVDAEIRAQDAPLSLL 415
ATL+ A + L+ + L + + Q S + ++ Q+A L +
Sbjct: 1050 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV- 1108
Query: 416 QTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHS 475
+ Q+ + A++ I S L E S + ED SL L DH
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQQSSLENENE--------SVIKEREDLKSLYDSLIKDHE 1160
Query: 476 SLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQ 535
LE + + L+ K G + S+ + E DL E +
Sbjct: 1161 KLE-------------LLHERQASEYESLISKH----GTLKSAHKNLEVEHRDL---EDR 1200
Query: 536 DSQVPLEKETLKSLGE--EIQESLKTLENQSHETLERENQE-CPRS---------LEEDL 583
+Q+ +K L+ L + ++++ LEN++HET+ E ++ C + L ++
Sbjct: 1201 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
Query: 584 ETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQ-ELMKSLEGN 642
E L++ K K LL + ++ + + +LK ++ + S + NQ EL+ L+GN
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ--LDITSTKLNNQCELLSQLKGN 1318
Query: 643 LETFLFPGTENQELVSSLQ-----------ENLESLTALEKENQEPL-------RSPEVG 684
LE EN+ L+ +Q +N+ES E ++ + R E
Sbjct: 1319 LE------EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL 1372
Query: 685 DEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSL 744
+E+ + + P R + R L K ++ + E + + P +++ +
Sbjct: 1373 EEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR--ERQKSLTLTPTRSDSSEGF 1430
Query: 745 RSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQ 804
L QD + ++ + + ++LG +K + LK L RP +++
Sbjct: 1431 LQLPHQDSQDSSSVGSNSLEDGQTLG---------TKKSSMVALKRLPFLRNRP---KDK 1478
Query: 805 EFLKSLKEESVEAVKSLETEILESLKSAGQENLE 838
+ +K+ S+ +++ +L + ENLE
Sbjct: 1479 DKMKACYRRSMSMNDLVQSMVLAGQWTGSTENLE 1512
Score = 39.3 bits (90), Expect = 0.031
Identities = 66/315 (20%), Positives = 137/315 (43%), Gaps = 27/315 (8%)
Query: 19 LEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAE 78
+E Y ARV+ L+E N++L L Q T R+ D+L L Q + H E
Sbjct: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS---DKLHELEKENLQLKAKLHDME 395
Query: 79 VARDNLAEELEGVAGRCQQLRLARERT----------TEEVARNRRAVEAEKCA-----R 123
+ RD +++E + L +A++++ E+++R EA + +
Sbjct: 396 MERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN 455
Query: 124 AWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLG 183
SS++ +LE E ++L EE R +++ A + + + +VE L +
Sbjct: 456 ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
Query: 184 EAWRGAVRGYQERVAHMETSLGQARERLGRAVQGARE-GRLELQQLQAERGGLLERRAAL 242
+ + + ++ L + + +L + ++ RE +++ L+ E L + ++L
Sbjct: 516 QEKQSL-----QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSL 570
Query: 243 EQRLEGRWQERLRATEK-FQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKM--SLSLEV 299
QR + + R++ EK ++ E++++ L + + +++L H K + E+
Sbjct: 571 RQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
Query: 300 ATYRTLLEAENSRLQ 314
LE EN LQ
Sbjct: 631 ENELHHLEKENELLQ 645
Score = 36.6 bits (83), Expect = 0.20
Identities = 59/286 (20%), Positives = 116/286 (40%), Gaps = 39/286 (13%)
Query: 25 RVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWREKHAAEVARDN- 83
++K LE++NE L+ + LR +S ++ E ++ ++N
Sbjct: 552 QIKILEQENEHLNQTVSSLRQRSQISA---------------------EARVKDIEKENK 590
Query: 84 -LAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRV 142
L E ++ + + ++ + + +E+ + EK RA ELE EL L
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYK-----EKGERA------EELENELHHLEK 639
Query: 143 AHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMET 202
+E + + + A + E +L + L ++++ +Q E
Sbjct: 640 ENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL-DSFKNLT--FQLESLEKEN 696
Query: 203 S-LGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQ 261
S L + L R V+ + +++ QLQ E L + L++ LE + + TE+ +
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLE-LLKASFKKTERLE 755
Query: 262 LAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLE 307
++ + L+ E Q LQ + + QQL L +E T + LE
Sbjct: 756 VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 95.5 bits (236), Expect = 4e-19
Identities = 153/652 (23%), Positives = 279/652 (42%), Gaps = 106/652 (16%)
Query: 352 SPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPT-PQAPSPAVDAEIRAQDA 410
S L S LE + L ++E Q+ +LA+ PP P+ +AE +D+
Sbjct: 455 SQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDS 514
Query: 411 PLSL-LQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQS----PEDHAS 465
SL LQ R+QAP P PA+ G E+ Q +E GQ PE+ +
Sbjct: 515 AASLSLQLSLQREQAPSP---------PAACEKGKEQHS-QAEELGPGQEEAEDPEEKVA 564
Query: 466 LAP--PLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEI 523
++P P+SP+ S E S L E A+ +V+ Q+ +
Sbjct: 565 VSPTPPVSPEVRSTEPVAPPEQLSEA-------------ALKAMEEAV-AQVLEQDQRHL 610
Query: 524 WEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDL 583
E + +++++ E+E + L ++ ++SL +L + + +E E R EE+
Sbjct: 611 LESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA---RMREEES 667
Query: 584 ETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNL 643
+ L L + + + E E+EA +LQ L++E + K+ +L
Sbjct: 668 QRLSWLRAQVQSSTQADEDQIRAEQEA-------------SLQKLREELESQQKAERASL 714
Query: 644 ETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSL 703
E +N++++ L+E +E A EK Q L + + E+AL+ L ++ L
Sbjct: 715 EQ------KNRQMLEQLKEEIE---ASEKSEQAALNAAK---EKALQQLREQ-------L 755
Query: 704 EDENKEAFRSLEKENQEPLK----TLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLE 759
E E KEA +LEKE+ L+ +LE + + +V L+ + ++ + E Q Q+ L +E
Sbjct: 756 EGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE 815
Query: 760 KETQQRRRSLG----EQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESV 815
Q+ + E + ++V+ E + LD+ ++ E+Q+ + +E+
Sbjct: 816 HRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDK-----MKEEHQQVMAKAREQYE 870
Query: 816 EAVKSLETEI-------LESLKSAGQENLETLKSPETQ--APLWTPEEINQGAMNPLE-- 864
+ E+ LE L+ A + LET++ + + L + + LE
Sbjct: 871 AEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELD 930
Query: 865 -----KEIQEPLESVEVNQETFR-----LLEEENQESLRSLGAWNLENLRSPEEVDKESQ 914
K+++ L +EV +ET R LL+ + Q +L+S A + EE KE
Sbjct: 931 LETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEA--TATHQQLEEAQKEHT 988
Query: 915 RNLEEEENLGKGEYQESLRSLEEEGQE---LPQSADVQRWEDTVEKDQELAQ 963
L+ + L + + R L+ E Q QS +Q+ ++E + + Q
Sbjct: 989 HLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ 1040
Score = 74.7 bits (182), Expect = 7e-13
Identities = 138/646 (21%), Positives = 264/646 (40%), Gaps = 68/646 (10%)
Query: 391 PPTPQAPS-PAVDAEIRAQDAPLSLLQTQGGRKQAPEPL---RAEARVAIPASVLPGPEE 446
PPTP PS P D+ + + A Q G R PE ++E ++ V P +
Sbjct: 278 PPTPCKPSSPGADSSLSS--AVGKGRQGSGARPGLPEKEENEKSEPKICRNL-VTPKADP 334
Query: 447 PGGQRQEASTGQSPEDHASLAPPLS--------PDHSSLEAKDGESGGSRVFSICRGEGE 498
G + +AS ++PED S P + ++G S S+ I E
Sbjct: 335 TGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE 394
Query: 499 GQIWGLVEKET----AIEGKVVSSLQQEIWEEEDLNRK---EIQDSQVPL---EKETLKS 548
Q+ + + ++ S + + + + + L+ + +Q PL +K+ +S
Sbjct: 395 PQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQS 454
Query: 549 LGEEIQ-ESLKTLENQSHETLEREN--QECPRSLEEDLETLKSLE-----KENKELLKDV 600
+E+Q + K LE + L E Q PRSL + E + E KE +EL +D
Sbjct: 455 SQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDS 514
Query: 601 EVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSL 660
L+ + P+ + + + +EL E E ++ +
Sbjct: 515 AASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQE-----------EAEDPEEKV 563
Query: 661 QENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQE 720
+ + E + EP+ PE E AL+ + + + LE + + S +++ Q+
Sbjct: 564 AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAM---EEAVAQVLEQDQRHLLESKQEKMQQ 620
Query: 721 PLKTLEEEDQSIVRPLETENHKSLRSLEEQ-----DQETLRTLEKETQQ------RRRSL 769
+ L +E++ + L + +SL SL E+ ++E R E+E+Q+ + +S
Sbjct: 621 LREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSS 680
Query: 770 GEQDQMTLRPPEKVDL----EPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEI 825
+ D+ +R ++ L E L+S + LE +N++ L+ LKEE +EA + E
Sbjct: 681 TQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEE-IEASEKSEQAA 739
Query: 826 LESLKSAGQENLETLKSPETQAPLWTPEEINQGAM----NPLEKEIQEPLESVEVN-QET 880
L + K + L E + + T E+ + + + LE + +E + S++ QE
Sbjct: 740 LNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEA 799
Query: 881 FRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQ 940
+ E + Q+ L + + + E L E+ +GE++ L ++EE Q
Sbjct: 800 QQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQ 859
Query: 941 ELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQD 986
++ A Q + ++ EL + ++ E EL Q+
Sbjct: 860 QVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQE 905
Score = 60.1 bits (144), Expect = 2e-08
Identities = 103/481 (21%), Positives = 193/481 (40%), Gaps = 84/481 (17%)
Query: 561 ENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKE 620
EN+ E N P++ E K+ EKE E D +EA KE
Sbjct: 315 ENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAA-------KE 367
Query: 621 DTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLR- 679
+ +L++ + + + LE + + +L S+ + +S L+ + +
Sbjct: 368 PKKKASALEEGSSDASQELE------ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISE 421
Query: 680 --------SPEVGD--EEALRPLTKENQEPLRSLEDE-NKEAFRSLEKENQEPLKTLEEE 728
SP +G +A +PL E+++ +S +DE + + LE+ PL EE
Sbjct: 422 HLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPH-EER 480
Query: 729 DQSIVRPLET--------ENHKSLRSLEEQDQETLRTLE--------------------K 760
QS R L T E + EE +++ +L K
Sbjct: 481 AQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGK 540
Query: 761 ETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEI-----ARPLENENQEFLKSLKEESV 815
E + LG + P EKV + P + E+ P E ++ LK+++E
Sbjct: 541 EQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVA 600
Query: 816 EAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVE 875
+ ++ + +LES + Q+ E L E + L ++ Q +++ L + +Q+ +E
Sbjct: 601 QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQ-SLSSLRERLQKAIE--- 656
Query: 876 VNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSL 935
+E R+ EEE+Q +W ++S + D E Q E+E +L K LR
Sbjct: 657 --EEEARMREEESQRL-----SWLRAQVQSSTQAD-EDQIRAEQEASLQK------LRE- 701
Query: 936 EEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVV 995
E E Q+ + A ++ +K++++ ++ + E ++A LN ++ E +
Sbjct: 702 ELESQQKAERASLE------QKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQL 755
Query: 996 E 996
E
Sbjct: 756 E 756
Score = 57.0 bits (136), Expect = 1e-07
Identities = 110/487 (22%), Positives = 179/487 (36%), Gaps = 95/487 (19%)
Query: 866 EIQEPLESVEVNQETFRLLEE--ENQESLRSLGAWNLENLRSPEEVDKESQRNLEEE-EN 922
E+ P + ++ + T LL E++ +L LG N EE D +S + E N
Sbjct: 181 ELMLPSQGLKTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRN 240
Query: 923 L--------GKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVEN 974
L G EY+ESLR+ + E + DV D SP + + +
Sbjct: 241 LHLDIGALGGDFEYEESLRTSQPE-----EKKDVSLDSDAAGPPTPCKPSSPGADSSLSS 295
Query: 975 EDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGG 1034
V +G + +P + E EPK R LV + G
Sbjct: 296 -------------------AVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTG 336
Query: 1035 AEGLQDPEGQSQQ----VGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGS---E 1087
+E + E ++ + G G + + E + + G AS E+ + E
Sbjct: 337 SEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKA--SALEEGSSDASQELEISEHMKE 394
Query: 1088 PAMGESAAGAEPGPGQGVG-GLGD--PGHLTREEVMEPPLEEESLEAKRVQGLE------ 1138
P + +S A ++P G+ G HL +V+ P L +A++ G+E
Sbjct: 395 PQLSDSIA-SDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQ 453
Query: 1139 GPRKDLEEAGGLGTE---FSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHT 1195
+ +L+ G E LP + R P EE + P G E AE LG
Sbjct: 454 SSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGED 513
Query: 1196 GS------------DAPSPWPL----------------GSEEAEEDVPPVLVSPSPTYTP 1227
+ APSP G EEAE+ V VSP+P P
Sbjct: 514 SAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP---P 570
Query: 1228 ILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEESRE--- 1284
+ + +P A Q + ++ EA+ +V + + + E QE+ ++ RE
Sbjct: 571 VSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQR----HLLESKQEKMQQLREKLC 626
Query: 1285 ESEEDEL 1291
+ EE+E+
Sbjct: 627 QEEEEEI 633
Score = 41.2 bits (95), Expect = 0.008
Identities = 146/643 (22%), Positives = 229/643 (35%), Gaps = 119/643 (18%)
Query: 810 LKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQE 869
L+E+ E E EILE + G ++ +K PE +W E G + PL E +
Sbjct: 14 LEEDYDETYIPSEQEILEFAREIG---IDPIKEPEL---MWLARE---GIVAPLPGE-WK 63
Query: 870 PLESVEVNQETFRLLEEENQ------ESLRSLGAWNLENLRSPEEVDKESQRNLEEEENL 923
P + + + F ++ E RSL L + + K+ ++ E+++
Sbjct: 64 PCQDITGDIYYFNFANGQSMWDHPCDEHYRSLVIQERAKLSTSGAIKKKKKKK-EKKDKK 122
Query: 924 GKGEYQESLR---SLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAEL 980
+ + SL SL L A ++ DT +Q G + EL
Sbjct: 123 DRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPPSALRGSQSVSLGSSVESGRQLGEL 182
Query: 981 NLREQDGFTGKEEVVEQGELNATEE----VWIPGEGHPESPEPKEQRGLVEGASVKGGAE 1036
L Q K +G L + E + + G G + E +E+ + SV +E
Sbjct: 183 MLPSQGL---KTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEEES---DNQSVHSSSE 236
Query: 1037 GLQDPEGQSQQVGAPG--LQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESA 1094
L++ +GA G + + L + +P + DV+ D A P +S+
Sbjct: 237 PLRNLH---LDIGALGGDFEYEESLRTS-QPEEKKDVSLDSDAAGPPTPCKPSSPGADSS 292
Query: 1095 AGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEF 1154
+ G G+ G PG +EE E E K + L P+ D G+E
Sbjct: 293 LSSAVGKGRQGSG-ARPGLPEKEE-------NEKSEPKICRNLVTPKAD-----PTGSE- 338
Query: 1155 SELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDV 1214
P K+ SE EAP +A + + P EE D
Sbjct: 339 ---PAKA-------------SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDA 382
Query: 1215 PPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGR-AEALGKVESEQEELGSGEIPE 1273
L P L D+ P++ + +G + R +E L V+ LG G +
Sbjct: 383 SQELEISEHMKEPQLSDSIASDPKSFHGLD--FGFRSRISEHLLDVDVLSPVLG-GACRQ 439
Query: 1274 GPQEEGEESREESE--EDELGETLPD------STPLGFYLRSPTSPRWDPTGEQRPPPQG 1325
Q G E +++S+ +DEL S PL R+ + PR T E+ PPQG
Sbjct: 440 AQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEE--PPQG 497
Query: 1326 ETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGE 1385
G+ W A EE G DS S +
Sbjct: 498 PEGQPEWKEA---------------------EELGEDSAASLSLQ--------------- 521
Query: 1386 VAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEE 1428
++ Q P PAA ++ E A+E G+E ED EE
Sbjct: 522 LSLQREQAPS---PPAACEKGKEQHSQAEELGPGQEEAEDPEE 561
Score = 39.3 bits (90), Expect = 0.031
Identities = 63/261 (24%), Positives = 100/261 (38%), Gaps = 30/261 (11%)
Query: 86 EELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHE 145
+E+EG R +L +E + +A+ R EAE+ R + + L ELE L+ AHE
Sbjct: 841 QEVEGEHER--RLDKMKEEHQQVMAKAREQYEAEE--RKQRAELLGHLTGELERLQRAHE 896
Query: 146 EERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLG 205
E + + +E+L RR R R Q+ +ET
Sbjct: 897 RELETVRQEQH----------------KRLEDLRRR----HREQERKLQDLELDLETRAK 936
Query: 206 QARERLGRAVQGAREGRLELQQL---QAERGGLLERRAALEQRLEGRWQER---LRATEK 259
+ RL R E QQL Q + E A Q+LE +E L++ ++
Sbjct: 937 DVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQ 996
Query: 260 FQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGG 319
+ ++ L+ K L+SQ+ + QQL SL E + LL
Sbjct: 997 LREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPH 1056
Query: 320 SKTSLSFQDPKLELQFPRTPE 340
+ L +D + L +T E
Sbjct: 1057 FEPDLHIEDLRKSLGTNQTKE 1077
Score = 36.2 bits (82), Expect = 0.27
Identities = 81/337 (24%), Positives = 134/337 (39%), Gaps = 50/337 (14%)
Query: 7 EESFQMWELNRRLEAYLARV-----KALEEQNELLSAE----LGGLRAQSADTSW----- 52
EE ++ L+++ E L+ + KA+EE+ + E L LRAQ ++
Sbjct: 628 EEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQ 687
Query: 53 -RAHADDELAALRALVDQRWREKHAAEVAR-----DNLAEELEGVAGRCQQ-LRLARERT 105
RA + L LR ++ + + + A+ + + L EE+E Q L A+E+
Sbjct: 688 IRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKA 747
Query: 106 TEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPP 165
+++ R + E ++ AELER +L H E L +
Sbjct: 748 LQQL-REQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKI---------- 796
Query: 166 RGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRL-- 223
A E +L + LG+ V VA E L + V+G E RL
Sbjct: 797 --QEAQQKEEAQLQKCLGQV-EHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDK 853
Query: 224 ---ELQQLQAERGGLLE-----RRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQ 275
E QQ+ A+ E +RA L L G ERL+ + +L EQ K+ L+
Sbjct: 854 MKEEHQQVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERELETVRQEQHKR-LE 911
Query: 276 SQIAQVLEGRQQLAHLKMSL---SLEVATYRTLLEAE 309
+ E ++L L++ L + +V LLE +
Sbjct: 912 DLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQ 948
Score = 32.0 bits (71), Expect = 5.0
Identities = 46/199 (23%), Positives = 73/199 (36%), Gaps = 24/199 (12%)
Query: 1279 GEESREESEEDELGETLPDSTP-----------LGFYLRSPTSPRWDPTGEQRPPPQGET 1327
GEE+ EE EE+ +++ S+ LG S R E++
Sbjct: 215 GEETNEEDEEESDNQSVHSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSD 274
Query: 1328 GKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVA 1387
P +S G ++ S +G + G L E+ E+ +E + A
Sbjct: 275 AAGPPTPCKPSSPGADSSLSSAVG--KGRQGSGARPGLPEKEENEKSEPKICRNLVTPKA 332
Query: 1388 EPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREP--GAGRWGPGSSVGS 1445
+P G P + E + D ++GEEG +E +EP A GSS S
Sbjct: 333 DPTGSEPA---------KASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDAS 383
Query: 1446 LQALSSSQRGEFLESDSVS 1464
+ S E SDS++
Sbjct: 384 QELEISEHMKEPQLSDSIA 402
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 93.6 bits (231), Expect = 1e-18
Identities = 250/1052 (23%), Positives = 403/1052 (38%), Gaps = 200/1052 (19%)
Query: 100 LARERTTEEVARNRRAVEAEKCARAWLSSQ--VAELERELEALRVAHEEERVGLNAQAAC 157
LA + + R E E+ A L SQ V LE E+ LR +E L+ QA
Sbjct: 256 LALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLR----QEAQALSGQAKR 311
Query: 158 APRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQG 217
A EL R EA +R R+ ++ L + RERL Q
Sbjct: 312 A------------------ELYREEAEA----LRERAGRLPRLQEELRRCRERL----QA 345
Query: 218 AREGRLELQQLQAERGGLLERRAALEQRLEGRWQE--RLRATEKFQLA------------ 263
A + +L++ + G L +A LE++LE + RL T++ L
Sbjct: 346 AEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAEL 405
Query: 264 ------VEALEQEKQGLQSQIAQVLE------GRQQLAHLKMSLSLEV----ATYRTLLE 307
V+ L +E L+ ++ + LE G LA SL EV A LE
Sbjct: 406 DSLRHQVDQLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLE 465
Query: 308 AENSRL-------QTPGGGSKTSLSF-----------QDPKLELQFPRTPEG-----RRL 344
EN L Q GG L + P+ + F +P+G R
Sbjct: 466 RENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDG 525
Query: 345 GSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPP----TPQAPSPA 400
G L+P +L S L A+ E P QE A +P A+ P +PQ
Sbjct: 526 GPQALDLAPPALDSVLEASAECPQAPDSDPQE---AESPLQAAAMDPQASDWSPQESGSP 582
Query: 401 VDAEIRAQDA--------PLSLLQTQG-GRK-QAPEPLRAEARVAIPASVLPGPEEPGGQ 450
V+ + + A P S+ QG G K QAP+ L E G E P G+
Sbjct: 583 VETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETE---------GREAPQGE 633
Query: 451 RQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETA 510
+ G E P P LE ++G + G + G+ E + E +
Sbjct: 634 LVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQG---LDLATGQAEAR-----EHDQR 685
Query: 511 IEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLER 570
+EG V Q+ ++ + E+Q + P+ E+L S G QE+L+ Q L R
Sbjct: 686 LEGTVRDPAWQKPQQKSE-GALEVQVWEGPIPGESLAS-GVAEQEALREEVAQ----LRR 739
Query: 571 ENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQK 630
+ + LE L++ E L K++ R E EA + + E + ++++
Sbjct: 740 KAEALGDELEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEA 799
Query: 631 ENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALR 690
QEL + + E + LV E+L A +E ++ R + LR
Sbjct: 800 AGQELESASQ-----------EREALV-------EALAAAGRERRQWER-----EGSRLR 836
Query: 691 PLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLE-----TENHKSLR 745
++ +E ++ LE E ++ E+E +E E ++++VR E + L
Sbjct: 837 AQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRELE 896
Query: 746 SLEEQDQETLRTLEKETQ-QRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQ 804
+ QE LR EKE+Q QR + L ++ + L+ E L L R L+ E +
Sbjct: 897 QAALERQEFLR--EKESQHQRYQGLEQRLEAELQAAATSKEEALMELK---TRALQLEEE 951
Query: 805 EFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLE 864
F + K E +++E+ +N+ ++ + A L + QG + LE
Sbjct: 952 LFQLRQGPAGLGPKKRAEPQLVET------QNVRLIEVERSNAMLVAEKAALQGQLQHLE 1005
Query: 865 KEI--------QEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRN 916
++ + L+S + + RL E++ ++ + L EV +E R
Sbjct: 1006 GQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQG------QELHRKLEVLEEEVRA 1059
Query: 917 LEEEENLGKGEYQESLRSLEEEGQ-ELPQSADVQ----RWEDTVE--KDQELAQESPPG- 968
+ + +G+ Q LR + Q + Q A+++ R D + ELA G
Sbjct: 1060 ARQSQEETRGQQQALLRDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGR 1119
Query: 969 -------MAGVENEDEAELNLRE---QDGF--TGKEEVVEQGELNATEEVWIPGEGHPES 1016
A VE ++ A L RE QDG G EE + + + + E E
Sbjct: 1120 HEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRER 1179
Query: 1017 PEPKEQRGLVEGASVKGGAEGLQDPEGQSQQV 1048
E + +RG + G + E Q E QSQQ+
Sbjct: 1180 GELQGERGELRGRLARLELERAQ-LEMQSQQL 1210
Score = 65.9 bits (159), Expect = 3e-10
Identities = 158/653 (24%), Positives = 246/653 (37%), Gaps = 79/653 (12%)
Query: 49 DTSWRAHADDELAALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEE 108
D +W+ AL V W E +AE+ E + QLR E +E
Sbjct: 692 DPAWQKPQQKSEGALEVQV---WEGPIPGESLASGVAEQ-EALREEVAQLRRKAEALGDE 747
Query: 109 VARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGP 168
+ R +EA+ A LS ++A+ R A AH E QA A +
Sbjct: 748 LEAQARKLEAQNTEAARLSKELAQARR---AEAEAHREAEAQAWEQARLREAVEAAGQEL 804
Query: 169 PAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERL------GRA-VQGAREG 221
+ + E E L L A R R ++ + + A ER+ GR ++ A
Sbjct: 805 ESASQEREALVEALAAAGRER-RQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERE 863
Query: 222 RLELQQLQAERGGLLERRAALEQRLEGRWQERLRAT---EKFQLAVEALEQEKQGLQSQI 278
R E + LQAE + R L RLE +E +A ++F E+ Q QGL+ ++
Sbjct: 864 RREKEALQAELEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRL 923
Query: 279 AQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRT 338
L Q A K +E+ T LE E +L+ G + +E Q R
Sbjct: 924 EAEL---QAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRL 980
Query: 339 PEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPS 398
E R ++L V +L L LE + + LQ R L S
Sbjct: 981 IEVERSNAML-VAEKAALQGQL-QHLEGQLGS-------LQGRAQELL---------LQS 1022
Query: 399 PAVDAEIRAQDAPLSLLQTQGGR-KQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTG 457
A S+L+ QG + E L E R A + EE GQ+Q
Sbjct: 1023 QRAQEHSSRLQAEKSVLEIQGQELHRKLEVLEEEVRAARQSQ-----EETRGQQQALL-- 1075
Query: 458 QSPEDHASLAPPLSPDHSSLEA----KDGESGGSRVFSICRGEGEGQIWGLVEKETAIEG 513
DH +LA + LE R + E +G+ L + ++E
Sbjct: 1076 ---RDHKALAQLQRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEA 1132
Query: 514 KVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQ 573
+ V+ L E E L + + + E L+S + Q L L + E +
Sbjct: 1133 QEVALLA----ERERLMQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGE 1188
Query: 574 ECPRSLEEDLETLKSLEKENKELLK-----DVEVVR-PLEKEAVGQLKPTGKEDTQTL-- 625
R +LE + LE ++++L + D+ R + E + QL+ +E+ + L
Sbjct: 1189 LRGRLARLELERAQ-LEMQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLA 1247
Query: 626 --QSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQE 676
Q+L +EN+EL LE +LE+ L +E L+ L AL +E Q+
Sbjct: 1248 EVQALSRENREL---LERSLES-------RDHLHREQREYLDQLNALRREKQK 1290
Score = 55.5 bits (132), Expect = 4e-07
Identities = 181/767 (23%), Positives = 289/767 (37%), Gaps = 133/767 (17%)
Query: 703 LEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKET 762
++ E A + + + + L D + P E E RSL + R +
Sbjct: 167 VQSELAAAIQEVTQPGAGVVLALSGPDPGELAPAELEMLS--RSLMGTLSKLARERDLGA 224
Query: 763 QQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEF--LKSLKEESVEAVKS 820
Q+ L E++ + LRP E P + +A L N + L+ EE E +
Sbjct: 225 QRLAELLLEREPLCLRP-EAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLD 283
Query: 821 LETEI--LESLKSAGQENLETLKSPETQAPLWTPE----EINQGAMNPLEKEIQEPLESV 874
+ E+ LE+ ++ + L +A L+ E G + L++E++ E +
Sbjct: 284 SQAEVQGLEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERL 343
Query: 875 EVNQETFRLLEEENQ-----ESLRSLGAWNLENLRSPEEVDKESQR-NLEEEENLGKGEY 928
+ + LEEE E+ ++L LE R E+QR NL LG E
Sbjct: 344 QAAEAYKSQLEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLG--EA 401
Query: 929 QESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQ--ESPPGMAGVENEDEAELNLREQ- 985
L SL + +L E+ VE + EL + E PPG G A +L+++
Sbjct: 402 HAELDSLRHQVDQLA--------EENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEV 453
Query: 986 -DGFTGKEEVVEQG--ELNATEEVWI--PGEGHPESPEPKEQ------------------ 1022
+ G+ +E+ EL +V PG HP P+E
Sbjct: 454 REAEAGRLRTLERENRELRGLLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDH 513
Query: 1023 --RGLVEGAS-----------------VKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAI 1063
+GLV+ A ++ AE Q P+ Q+ +P LQA P+A
Sbjct: 514 SPQGLVQKARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESP-LQAAAMDPQAS 572
Query: 1064 EPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEP-GPG------QGVGGLGDPGHLTR 1116
+ ++ +P Q SPE G ++ A+ A P GPG Q +GG + +
Sbjct: 573 DWSPQESGSPVETQESPE-KAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQ 631
Query: 1117 EEVMEPP--LEEESLEAK---------RVQGLEGPRKDLEEAGGLGT---EFSELPGKSR 1162
E++ L +E E K +++ EGP + L+ A G L G R
Sbjct: 632 GELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVR 691
Query: 1163 DP-WEPPREGREES-EAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVS 1220
DP W+ P++ E + E + G P E+L + +EA + L
Sbjct: 692 DPAWQKPQQKSEGALEVQVWEGP---IPGESLASG---------VAEQEALREEVAQLRR 739
Query: 1221 PSPTYTPILEDAPGPQPQAEGSQEASWGVQ----GRAEALGKVESEQEELGSGEIPEGPQ 1276
+ LE A + +A+ ++ A + RAEA E+E + + E +
Sbjct: 740 KAEALGDELE-AQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLREAVE 798
Query: 1277 EEGEESREESEEDE-LGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPA 1335
G+E S+E E L E L + +W+ G R Q E +E
Sbjct: 799 AAGQELESASQEREALVEALAAA--------GRERRQWEREG-SRLRAQSEAAEERMQ-- 847
Query: 1336 VLASEG---LEAPPSEKEEGE----EGEEECGRDSDLSEEFEDLGTE 1375
VL SEG LE E+ E E E E+ R +L E L E
Sbjct: 848 VLESEGRQHLEEAERERREKEALQAELEKAVVRGKELGARLEHLQRE 894
Score = 49.3 bits (116), Expect = 3e-05
Identities = 95/341 (27%), Positives = 142/341 (41%), Gaps = 56/341 (16%)
Query: 15 LNRRLEAYLARVKALEEQNEL--------LSAELGGLRAQSADTSWRAHADDELAA---L 63
L +RLEA L +E+ + L EL LR A + A+ +L +
Sbjct: 919 LEQRLEAELQAAATSKEEALMELKTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNV 978
Query: 64 RALVDQRWR-----EKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEA 118
R + +R EK A + +L +L + GR Q+L L +R E +R ++A
Sbjct: 979 RLIEVERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSR----LQA 1034
Query: 119 EKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEEL 178
EK L Q EL R+LE L EE R +Q + A R A A +L
Sbjct: 1035 EKSV---LEIQGQELHRKLEVL---EEEVRAARQSQEETRGQQQALLRDHKALA----QL 1084
Query: 179 ARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQ-GAREGRLELQQ--LQAERGGL 235
RR G + +++ A+M RE GR Q A+ +E Q+ L AER L
Sbjct: 1085 QRRQEAELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERL 1144
Query: 236 LE---RRAALEQRLEGRWQERLRA--------TEKFQLAVE---------ALEQEKQGLQ 275
++ R+ LE+ L E RA E+ +L E LE E+ L+
Sbjct: 1145 MQDGHRQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLE 1204
Query: 276 SQIAQVLEGRQQ--LAHLKMSLSLEVAT-YRTLLEAENSRL 313
Q Q+ E QQ L+ +++ E+ T R+ E EN +L
Sbjct: 1205 MQSQQLRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQL 1245
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 91.7 bits (226), Expect = 5e-18
Identities = 180/776 (23%), Positives = 298/776 (38%), Gaps = 139/776 (17%)
Query: 674 NQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIV 733
++ L+ + +++ ++P +EP L++ KEA E +N +++L E +
Sbjct: 451 SERNLQESVLSEQDLMQP-----EEPDYLLDEMTKEA----EIDNSSTVESLGETTDIL- 500
Query: 734 RPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGE--QDQMTLRPPEKVDLEPLKSL 791
N + SL ++++L+ + Q++++++GE QD + + E + +
Sbjct: 501 ------NMTHIMSLNS-NEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEM 553
Query: 792 DQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWT 851
+ A ++ +Q + ++EA E EI E + A ++ E +A
Sbjct: 554 KEGKACK-QHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEEN 612
Query: 852 PEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDK 911
+ ++ G E + + EV++ + + E ++ G E S E +
Sbjct: 613 VK-VHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA-EDGPEGRGDGTCEEGSSGAEHWQ 670
Query: 912 ESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRW-----EDTVEKDQELAQESP 966
+ +R E++ G+GE +E G+ + A+ + W E+ +K++E +
Sbjct: 671 DEEREKGEKDK-GRGE-------MERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKE 722
Query: 967 PGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLV 1026
E +E E++G +EE E E + GE E E K++
Sbjct: 723 RNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERA- 781
Query: 1027 EGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGS 1086
G KG EG Q EG+ ++ G ++ GG+ EV
Sbjct: 782 -GKEEKGEEEGDQG-EGEEEETEGRG----------------EEKEEGGEVEGGEV---- 819
Query: 1087 EPAMGESAAGAEPGPGQGVGGLGDPGHLT-REEVMEPPLEEESLEAK-RVQGLEGPRKDL 1144
E GE E G G+ G G+ EE E EEE E + +G EG +
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE 879
Query: 1145 EEAG-GLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPW 1203
EE G G G E E G+ E EG EE E E G EE +
Sbjct: 880 EEEGEGEGEEEGEGEGEEE---EGEGEGEEEGEGE---GEEEEGEGK------------- 920
Query: 1204 PLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQ 1263
G EE EE + G + + EG E G +G E G+ E E+
Sbjct: 921 --GEEEGEEG-----------------EGEGEEEEGEGEGEDGEG-EGEEEE-GEWEGEE 959
Query: 1264 EELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPP 1323
EE G GE E + EGEE E EE+E GE + + GE+
Sbjct: 960 EE-GEGEGEEEGEGEGEEGEGEGEEEE-GEGEGE----------------EEEGEEEGEE 1001
Query: 1324 QGETGKEGWDPAVLASEGLEAPPSEKEEGE-EGEEECGRDSDLSEEFEDLGTEAPFLPGV 1382
+GE +EG EG E EEGE EGEEE G + E E G E
Sbjct: 1002 EGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRR---- 1057
Query: 1383 PGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWG 1438
E E + +G+ +EE ++GEE ++ + G+ ++G
Sbjct: 1058 NREEEE---------------EEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYG 1098
Score = 89.7 bits (221), Expect = 2e-17
Identities = 147/623 (23%), Positives = 234/623 (37%), Gaps = 70/623 (11%)
Query: 530 NRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLE----RENQECPRSLEEDLET 585
N K ++ S V +K+ +++GE Q++ T + S E E +E + C + + + +
Sbjct: 511 NEKSLKLSPVQKQKKQ-QTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGI-- 567
Query: 586 LKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLET 645
+ E D EV P EKE K G E+ + + N+E +K G
Sbjct: 568 FMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEV-----EANEENVKVHGGR--- 619
Query: 646 FLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLED 705
+E L ++L + + + + E G E +E +D
Sbjct: 620 --------KEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQD 671
Query: 706 ENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQR 765
E +E + E + +E + E E K E++ +E + +KE Q
Sbjct: 672 EERE-----KGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQE 726
Query: 766 RRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEI 825
GE++ E D+E E E +E + E VE + E
Sbjct: 727 MEEGGEEEHGEGEEEEG---------DREEEEEKEGEGKE---EGEGEEVEGEREKEEGE 774
Query: 826 LESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLE 885
+ + AG+E + + + EE +G EKE +E EV + E
Sbjct: 775 RKKEERAGKEEKGEEEGDQGEGE----EEETEGRGE--EKEEGGEVEGGEVEEGKGEREE 828
Query: 886 EENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQS 945
EE + G E E +E + EEEE GKGE + EEEG+E
Sbjct: 829 EEEE------GEGEEE-----EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE 877
Query: 946 ADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEE 1005
+ + E E++ E E G E E+E E E++G EE E+GE EE
Sbjct: 878 GEEEEGEGEGEEEGEGEGEEEEGEG--EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEE 935
Query: 1006 VWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEP 1065
GEG E +E+ G EG +G EG ++ EG+ ++ G + +G E E
Sbjct: 936 EG-EGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG-EEEEGEGEGEEE 993
Query: 1066 LVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLE 1125
E++ G+ G E GE E G+G G EE E E
Sbjct: 994 EGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEG---------EEEEGEEEGE 1044
Query: 1126 EESLEAKRVQGLEGPRKDLEEAG 1148
E E + + ++ EE G
Sbjct: 1045 EREKEGEGEENRRNREEEEEEEG 1067
Score = 87.4 bits (215), Expect = 1e-16
Identities = 169/742 (22%), Positives = 261/742 (35%), Gaps = 135/742 (18%)
Query: 843 PETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAW---- 898
P + P + + + ++ E+++ +P E + E + E +N ++ SLG
Sbjct: 443 PNSVFPRCSERNLQESVLS--EQDLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDIL 500
Query: 899 ---NLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTV 955
++ +L S E+ K S ++++ Q++ + ++ E + ++++ +
Sbjct: 501 NMTHIMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACK 560
Query: 956 EK-DQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHP 1014
+ Q + P +++E E+ ++ K +E+ E+ A EE G
Sbjct: 561 QHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRK 620
Query: 1015 ESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPG 1074
E E L + A V EG+++ VG ED
Sbjct: 621 EKTEILSD-DLTDKAEVS---------EGKAKSVGE----------------AEDGPEGR 654
Query: 1075 GDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGH----LTREEVMEPPLEEESLE 1130
GD E G+E E E G+G + PG L +E + EE +
Sbjct: 655 GDGTCEEGSSGAEHWQDEEREKGEKDKGRGE--MERPGEGEKELAEKEEWKKRDGEEQEQ 712
Query: 1131 AKRVQGLEGPRKDLEEAGGLGT--EFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFP 1188
+R QG + R E GG E E G + E EG+EE E E G E
Sbjct: 713 KEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGERE--- 769
Query: 1189 AETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWG 1248
EE E E+ G + + E + G
Sbjct: 770 ------------------KEEGERKK---------------EERAGKEEKGEEEGDQGEG 796
Query: 1249 VQGRAEALGKVESEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSP 1308
+ E G+ + E E+ GE+ EG E EE E E+E GE + G
Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEE---GEGEEEE 853
Query: 1309 TSPRWDPTGEQ-RPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGE---EGEEECGRDSD 1364
+ + GE+ +GE G+ + EG E E EE E EGEEE G
Sbjct: 854 GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE-GEGEG 912
Query: 1365 LSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEE 1424
EE E G E GE E G+ DGE +G +E E E EE
Sbjct: 913 EEEEGEGKGEEEGEEGEGEGEEEEGEGE-----------GEDGEGEGEEEEGEWEGEEEE 961
Query: 1425 DQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTA 1484
+ EG E G G G G GE E + G +
Sbjct: 962 GEGEGEEEGEGEGEEGEGEGE----EEEGEGEGEEEE-----------------GEEEGE 1000
Query: 1485 LETESQDSAEPSGSEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIG-VNGQGPNLE 1543
E E ++ E G EEE E +V G +E G E G G + G G+ E
Sbjct: 1001 EEGEGEEEGEGEGEEEE--------EGEVEGEVE---GEEGEGEGEEEEGEEEGEEREKE 1049
Query: 1544 GKSQHVNGGVMNGLEQSEEVGQ 1565
G+ + N E+ EE G+
Sbjct: 1050 GEGEE---NRRNREEEEEEEGK 1068
Score = 77.0 bits (188), Expect = 1e-13
Identities = 170/692 (24%), Positives = 248/692 (35%), Gaps = 154/692 (22%)
Query: 900 LENLRSPEEVDKESQ-RNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKD 958
L+ + E+D S +L E ++ + SL S E+ + P VQ+ +K
Sbjct: 475 LDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSP----VQK-----QKK 525
Query: 959 QELAQESPPGMAGVENEDEAELN-LREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESP 1017
Q+ E A EN+D E + E ++ V QG I E
Sbjct: 526 QQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVE 585
Query: 1018 EPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQ 1077
P+E+ G + KG Q+ E + V G G E E ++ DD+ D+
Sbjct: 586 IPEEKEGAEDS---KGNGIEEQEVEANEENVKVHG-----GRKEKTE-ILSDDLT---DK 633
Query: 1078 ASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGL 1137
A EV G ++GE+ G E G G G G G E +EE + ++ +G
Sbjct: 634 A--EVSEGKAKSVGEAEDGPE-GRGDGTCEEGSSG-------AEHWQDEEREKGEKDKG- 682
Query: 1138 EGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGS 1197
R ++E G E +E ++ W+ R+G E+ + E +G ++
Sbjct: 683 ---RGEMERPGEGEKELAE-----KEEWKK-RDGEEQEQKEREQGHQKE----------- 722
Query: 1198 DAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALG 1257
++E EE G + EG +E +G E
Sbjct: 723 --------RNQEMEEG--------------------GEEEHGEGEEE-----EGDREEEE 749
Query: 1258 KVESEQEELGSGEIPEGPQE--EGEESREE-SEEDELGETLPDSTPLGFYLRSPTSPRWD 1314
+ E E +E G GE EG +E EGE +EE + ++E GE D G T R +
Sbjct: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQ---GEGEEEETEGRGE 806
Query: 1315 PTGEQRPPPQGET--GKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDL 1372
E GE GK + EG E +EE EGEEE G E E
Sbjct: 807 EKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866
Query: 1373 GTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREP 1432
G E GE E G+ + +GE +G + E GEE EE + EG E
Sbjct: 867 GEEE-------GEEGEGEGE-----------EEEGEGEGEEEGEGEGEE-EEGEGEGEEE 907
Query: 1433 GAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDS 1492
G G G + GE E + E E +D
Sbjct: 908 GEGEGEEEEGEGKGEEEGEEGEGEGEEEEG-----------------------EGEGEDG 944
Query: 1493 AEPSGSEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGG 1552
E G EEE + E E + G E+ G G+G EG+ + G
Sbjct: 945 -EGEGEEEEGEWEGEEEEGEGEG--------EEEG--------EGEGEEGEGEGEEEEGE 987
Query: 1553 VMNGLEQSEEVGQGMPLVSEGDRGSPFQEEEG 1584
E+ EE G+ E G +EEEG
Sbjct: 988 GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019
Score = 65.1 bits (157), Expect = 5e-10
Identities = 97/394 (24%), Positives = 142/394 (36%), Gaps = 77/394 (19%)
Query: 1250 QGRAEALGKVESEQEELGSGEIPEGP---QEEGEESREESEEDELGETLPDSTPLGFYLR 1306
+G+A+++G+ E E G G EG + +E RE+ E+D+
Sbjct: 638 EGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDK---------------- 681
Query: 1307 SPTSPRWDPTGEQRPPPQGE---TGKEGWDPAVLASEGLEAPPSEKEEG----------E 1353
GE P +GE KE W +G E E+E+G E
Sbjct: 682 --------GRGEMERPGEGEKELAEKEEWKKR----DGEEQEQKEREQGHQKERNQEMEE 729
Query: 1354 EGEEECGR------DSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDG 1407
GEEE G D + EE E G E V GE + G+ + + A + G
Sbjct: 730 GGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKE--ERAGKEEKG 787
Query: 1408 ESDGFADEEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSV 1467
E +G D+ E EE E + E +E G G G + + GE E +
Sbjct: 788 EEEG--DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEE 845
Query: 1468 PWDDSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLEIPSGMEDAG 1527
+ + E E ++ E E E + E E++ G G E+ G
Sbjct: 846 EGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEG-----EGEEEEG 900
Query: 1528 PGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQGMPLVSEGDRGSPFQEEEGSAL 1587
G G+G EG+ + G E EE G+G EG+ G E EG
Sbjct: 901 EGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEG-----EGEDG----EGEGEEE 951
Query: 1588 KTSWAGAPVHLGQGQFLKFTQREGDRESWSSGED 1621
+ W G G+G EG+ E GE+
Sbjct: 952 EGEWEGEEEE-GEG--------EGEEEGEGEGEE 976
Score = 45.1 bits (105), Expect = 6e-04
Identities = 119/577 (20%), Positives = 216/577 (37%), Gaps = 46/577 (7%)
Query: 450 QRQEASTGQSPEDHASLAPPLSPDHSSL-EAKDGESGGSRVFSICRGEGEGQIWGLVEKE 508
Q+++ + G+ +D A S ++ + E K+G++ V G+ +
Sbjct: 523 QKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQ-----------GIFMTQ 571
Query: 509 TAIEGKVVSSLQQEIWEE----EDLNRKEIQDSQVPLEKETLKS----------LGEEIQ 554
A + S + EI EE ED I++ +V +E +K L +++
Sbjct: 572 PATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT 631
Query: 555 ESLKTLENQSHETLERENQECPR---SLEEDLETLKSLEKENKELLKDVEVVRPLEKEAV 611
+ + E ++ E E+ R + EE + + E +E + + +E+
Sbjct: 632 DKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGE 691
Query: 612 GQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQE-NLESLTAL 670
G+ + KE+ + ++E +E + + + G E + +E + E
Sbjct: 692 GEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK 751
Query: 671 EKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQ 730
E E +E EV E ++ +E E +E + +E + + E+E+
Sbjct: 752 EGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEG 811
Query: 731 SIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKS 790
V E E K R EE+++E E+ + GE+++ + E+ + +
Sbjct: 812 GEVEGGEVEEGKGER--EEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEE 869
Query: 791 LDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPET--QAP 848
+E E E E + E + E E E + G+E K E +
Sbjct: 870 EGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGE 929
Query: 849 LWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEE 908
EE +G E E +E E +E EE E G E EE
Sbjct: 930 GEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEG----EGEGEEEE 985
Query: 909 VDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPG 968
+ E + EEE +GE +E EE +E +V+ E E ++E +E
Sbjct: 986 GEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEE--- 1042
Query: 969 MAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEE 1005
G E E E E E++ +EE E+G+ T E
Sbjct: 1043 --GEEREKEGE---GEENRRNREEEEEEEGKYQETGE 1074
Score = 42.7 bits (99), Expect = 0.003
Identities = 79/333 (23%), Positives = 132/333 (39%), Gaps = 15/333 (4%)
Query: 445 EEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGL 504
EE G+R++ + E+ A + E ++ E+ G RGE E + G
Sbjct: 762 EEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG-------RGE-EKEEGGE 813
Query: 505 VEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQS 564
VE EGK ++E E E+ E ++ + E+E + GEE E + E
Sbjct: 814 VEGGEVEEGKGEREEEEEEGEGEE-EEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGE 872
Query: 565 HETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQT 624
E E +E EE+ E + E+E + ++ E+E G+ + G+E
Sbjct: 873 EGEGEGEEEEGEGEGEEEGEG-EGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGE 931
Query: 625 LQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENL----ESLTALEKENQEPLRS 680
+ + E + EG E + G E + +E E E+E E
Sbjct: 932 GEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGE 991
Query: 681 PEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEE-EDQSIVRPLETE 739
E G+EE E + E+E E +E E E EE E++ R E E
Sbjct: 992 EEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGE 1051
Query: 740 NHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQ 772
++ R+ EE+++E + E ++ R GE+
Sbjct: 1052 GEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
Score = 35.0 bits (79), Expect = 0.59
Identities = 91/400 (22%), Positives = 148/400 (37%), Gaps = 53/400 (13%)
Query: 446 EPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQ-IWGL 504
E GG+ + G+ E+ D E K+GE + EGEG+ + G
Sbjct: 728 EEGGEEEH---GEGEEEEG--------DREEEEEKEGEG---------KEEGEGEEVEGE 767
Query: 505 VEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQS 564
EKE K + ++E EEE Q E+E + GEE +E + +
Sbjct: 768 REKEEGERKKEERAGKEEKGEEEG--------DQGEGEEEETEGRGEEKEEGGEVEGGEV 819
Query: 565 HETL-ERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQ 623
E ERE +E EE+ E E +E + E E+E G+ + G+E
Sbjct: 820 EEGKGEREEEEEEGEGEEE-------EGEGEEEEGEGE-----EEEGEGKGEEEGEEGEG 867
Query: 624 TLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEV 683
+ + E + + EG E G E E E +E + + E
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEE---EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEE 924
Query: 684 GDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKS 743
G+E +E + E E +E E E +E EEE + E E +
Sbjct: 925 GEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEE 984
Query: 744 LRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPE--------KVDLEPLKSLDQEI 795
E +++E E+E + GE ++ E + + E + ++
Sbjct: 985 EGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGE 1044
Query: 796 ARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQE 835
R E E +E ++ +EE E K ET E+ + G+E
Sbjct: 1045 EREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 90.9 bits (224), Expect = 9e-18
Identities = 268/1197 (22%), Positives = 465/1197 (38%), Gaps = 258/1197 (21%)
Query: 5 MGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRA------------QSADTSW 52
+GEES ++ R+L+A L K ++N+ L EL R +S ++
Sbjct: 1471 IGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQ 1530
Query: 53 RAHADDELAALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARN 112
D L L L ++R +K E+ R L E + ++ C+ L+LA E TE+ +
Sbjct: 1531 NKEKDTVLGRLALLQEER--DKLITEMDRSLL--ENQSLSSSCESLKLALEGLTEDKEKL 1586
Query: 113 RRAVEAEKCARAWLSSQVAELEREL----------------EALRVAHEEERVGLNAQAA 156
+ +E+ K ++ S++ E +EL EA R+ H E V Q
Sbjct: 1587 VKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL 1646
Query: 157 CAP--RCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRA 214
A + E E+ + E R + Q+++ +E + +RL
Sbjct: 1647 YGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE----EENDRLRAE 1702
Query: 215 VQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGL 274
V A + E + LL A++++ LE + ++ E L ++ Q L
Sbjct: 1703 VHPAGDTAKECMET------LLSSNASMKEELE-----------RVKMEYETLSKKFQSL 1745
Query: 275 QSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQ 334
S+ + E Q L H Q G SK + K + Q
Sbjct: 1746 MSEKDSLSEEVQDLKH-----------------------QIEGNVSKQANLEATEKHDNQ 1782
Query: 335 FPRTPEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTP 394
T EG + +P + Q+ L T S +P
Sbjct: 1783 TNVTEEGTQ-----------------------SIPGETEEQDSLSMSTRPTCSESVPSAK 1819
Query: 395 QAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPAS---------VLPGPE 445
A +PAV + + D + LQ K+ L E + S +L
Sbjct: 1820 SA-NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQIS 1878
Query: 446 EPGGQR---QEAST-----GQSPEDHASLAPPLSPDHSSLEAKD----------GESGGS 487
G+ QE T Q ++ S L ++ E KD E GS
Sbjct: 1879 TKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK--ETAEEEKDDLEERLMNQLAELNGS 1936
Query: 488 RVFSICRGEGEGQIWG-LVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETL 546
+ + C+ + QI L+E E K VS L++E ++++ + +E E
Sbjct: 1937 -IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEE--------KQQLVKEKTKVESEIR 1987
Query: 547 KSLGEEIQESLKTLENQSH----ETLERENQECPRSLEEDL-----------ETLKSLEK 591
K E+IQ + K N+SH + L +E Q+ + L++D T+K+LE
Sbjct: 1988 KEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF 2047
Query: 592 ENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGT 651
E KD+E+ + +AV K E L E + L NL
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNL-------- 2099
Query: 652 ENQELVSSLQENLESLTALEKENQEPL-RSPEVGDEEALRPLTKENQEPLRS-------L 703
+L LQ N ES+ + K+ E L R E +E+ L+ K QE L + L
Sbjct: 2100 ---KLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKE-KKNMQEKLDALRREKVHL 2155
Query: 704 EDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEK--- 760
E+ E +L K+++E ++ L+E S V L KS+ SL++ + +K
Sbjct: 2156 EETIGEIQVTLNKKDKE-VQQLQENLDSTVTQLAAFT-KSMSSLQDDRDRVIDEAKKWER 2213
Query: 761 ------ETQQRRRSLGEQD---------QMTLRPPE-KVDLEPLK--------------S 790
++++ L E + QM++ E K+++ L+
Sbjct: 2214 KFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQ 2273
Query: 791 LDQEIARPLENENQEFLKSLKE------ESVEAVKSLETEILESLKSAGQENLETL-KSP 843
L Q++ L+ EN+E L L+E S + LE+E L+SLK + +L K
Sbjct: 2274 LQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESE-LKSLKDQLTDLSNSLEKCK 2332
Query: 844 ETQAPLWTPEEINQGAMNPLEKEIQ------EPLES-VEVNQE-TFRLLEEEN--QESLR 893
E + L +G + E +IQ E LE+ ++ ++E T RL EE N ++ +
Sbjct: 2333 EQKGNL-------EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKII 2385
Query: 894 SLGAWNLENLR-SPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWE 952
SL + E ++ + E+ ++ + ++E ENL E +E++ EE + + ++ +
Sbjct: 2386 SLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETL 2445
Query: 953 DTVEKD--QELAQ--ESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELN-ATEEVW 1007
T++K+ Q+ AQ M+ ++N ++D G + +E+ L+ E+
Sbjct: 2446 KTIKKENIQQKAQLDSFVKSMSSLQN---------DRDRIVGDYQQLEERHLSIILEKDQ 2496
Query: 1008 IPGEGHPESPEPKEQ-RGL------VEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQ 1057
+ E E+ + KE+ RGL + + K AE +Q E +Q + Q Q
Sbjct: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQ 2553
Score = 71.6 bits (174), Expect = 6e-12
Identities = 226/1068 (21%), Positives = 408/1068 (38%), Gaps = 168/1068 (15%)
Query: 14 ELNRRLEAYLARVKALEEQNELLSAELGGLRAQS-ADTSWRAHADDELAALRALVDQRWR 72
+LN A A+ + +EE NE+ S S A + E L+ +QR R
Sbjct: 934 QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993
Query: 73 EKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAE 132
+ AA + R L + + + L+ ++ R VE +K + + V
Sbjct: 994 KLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTS 1053
Query: 133 LERELEA-LRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVR 191
+E+E L+ E+ V E++ + + L E A
Sbjct: 1054 KCQEIEIYLKQTISEKEV------------------------ELQHIRKDLEEKL-AAEE 1088
Query: 192 GYQERVAHMETSLGQARERLGRAVQGAREGRLELQQL--------QAERGGLLERRAALE 243
+Q V M +L ++ E + +Q+L + L++ +
Sbjct: 1089 QFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVIS 1148
Query: 244 QRLEG---RWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQL--------AHLK 292
G W+ L EK + ALE+EK+ LQ ++ + L R+ + HL+
Sbjct: 1149 PPCTGSSEHWKPELE--EK----ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLR 1202
Query: 293 MSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLS 352
L + Y L E + + + ++ Q +L++Q + +G+ LP
Sbjct: 1203 EELKQQKDDYNRLQEQFDEQSK-----ENENIGDQLRQLQIQVRESIDGK-----LPSTD 1252
Query: 353 PTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPL 412
S P E P F ++ P L S P PS + DA +
Sbjct: 1253 QQESCSSTPGLEE---PLFKATEQ--HHTQPVLESN---LCPDWPSHSEDASALQGGTSV 1304
Query: 413 SLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPE-DHASLAPPLS 471
+ ++ Q +A E + E +V+ S L E Q QE Q E + +
Sbjct: 1305 AQIKAQLKEIEA-EKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 472 PDHSSLEAKDGESGGSRVFSI------------------CRGEGEGQIWG-LVEKETAIE 512
H+ + ES ++ + + E + G L EKE A+
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAAL- 1422
Query: 513 GKVVSSLQQEIWEEEDLNR--KEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLER 570
+ +Q EI E+EDL + + Q E +K L E+ E + E E+ R
Sbjct: 1423 ----TKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEES--R 1476
Query: 571 ENQECPRSLEEDLETLKSLEKENKELLKDVEVVR-PLEK------EAVGQLKPTGKE-DT 622
Q+ R L+ L + K KENK L +++ + R +E+ + Q+ KE DT
Sbjct: 1477 AKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536
Query: 623 --QTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQ----- 675
L LQ+E +L+ ++ +L ENQ L SS + +L L ++ +
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSL-------LENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 676 -EPLRSPEVGD----EEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQ 730
E L+S ++ + +E + L KE + L+S E+ + EA R Q ++ + +E Q
Sbjct: 1590 IESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERI-----QHVVEAVRQEKQ 1644
Query: 731 SI---VRPLETENHKSLRSLEEQDQ------ETLRTLEKETQQRRRSLGEQD---QMTLR 778
+ +R E ++ + L+E +Q E +R K QQ+ L E++ + +
Sbjct: 1645 ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVH 1704
Query: 779 P---PEKVDLEPLKSLDQEIARPLENENQEF-LKSLKEESVEAVKSLETEILESLKS--- 831
P K +E L S + + LE E+ S K +S+ + K +E ++ LK
Sbjct: 1705 PAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIE 1764
Query: 832 ---AGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEEN 888
+ Q NLE + + Q + EE Q E++ + + E+ + N
Sbjct: 1765 GNVSKQANLEATEKHDNQTNV--TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSAN 1822
Query: 889 QESLRSLGAWN-LENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEE--GQELPQS 945
+ + + + N + KE LEEE+ K E+ ++L + + Q +
Sbjct: 1823 PAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNK-EFSQTLENEKNTLLSQISTKD 1881
Query: 946 ADVQRWEDTVEK--------DQELAQESPPGMAGVENEDEAELNLREQ 985
+++ ++ V K +EL++ + E +D+ E L Q
Sbjct: 1882 GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQ 1929
Score = 68.6 bits (166), Expect = 5e-11
Identities = 109/517 (21%), Positives = 213/517 (41%), Gaps = 56/517 (10%)
Query: 519 LQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRS 578
L E EE L++ + ++ +E E +K +E +E + TL+ Q + + +
Sbjct: 122 LPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTE 181
Query: 579 LEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKS 638
+EE +K +E +E + ++ QL T E Q Q + +E ++
Sbjct: 182 MEE-FVMMKQQLQEKEEFISTLQ----------AQLSQTQAE--QAAQQVVREKDARFET 228
Query: 639 LEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPL-RSPEVGD--EEALRPLTKE 695
E L ++ + +Q+ L L +E++E L +V D ++ L +
Sbjct: 229 QVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQR 288
Query: 696 NQ---EPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIV------RPLETENHKSLRS 746
NQ + L+ +E E+ ++E E +E LE+ + + L+ E H L
Sbjct: 289 NQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
Query: 747 LEE--QDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQ 804
E+ Q Q L + +Q+ ++ E+ + +K E + D L+++N
Sbjct: 349 FEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACD-----ALKDQNS 403
Query: 805 EFLKSLKEESVEA---VKSLETEILESLKSAGQ-ENLETLKSPETQAPLWTPEEINQGAM 860
+ L+ E++V++ ++ LE ++ + K Q N L+ ET + P+ N+G
Sbjct: 404 KLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ 463
Query: 861 NPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEE 920
E+ I + R++E EN++ L + LE L++ E LE +
Sbjct: 464 AVTEENIASLQK---------RVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQ 514
Query: 921 ENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVE-----KDQELAQESPPGMAGVENE 975
G+ + + S S+ + + SA+ + +D +E K +EL+ E
Sbjct: 515 NRTGEADREVSEISIVDIANKRSSSAE-ESGQDVLENTFSQKHKELSVLLLEMKEAQEEI 573
Query: 976 DEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEG 1012
+L L+ + EV++Q E+ E GEG
Sbjct: 574 AFLKLQLQGKRAEEADHEVLDQKEMKQME-----GEG 605
Score = 62.0 bits (149), Expect = 5e-09
Identities = 121/531 (22%), Positives = 214/531 (40%), Gaps = 71/531 (13%)
Query: 505 VEKETAIEGKVVSSLQQEIWEEED-----LNRKE--IQDSQVPLEKETLKSLGEEIQESL 557
+E + ++ S L +EI +E L+ KE IQ + L ++ K + E E+L
Sbjct: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKE--LENL 2416
Query: 558 KTLENQSHETLERENQECPRSLEEDLETLKSLEKEN-------KELLKDVEVVRPLEKEA 610
+ E + + LE EN++ + +ETLK+++KEN +K + ++
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
Query: 611 VGQLKPTGK-------EDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSL--- 660
VG + + E Q +Q EN +L + + G +EN +L + L
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQY 2536
Query: 661 QENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKE---AFRSLEKE 717
+E+L + ++ Q+ L ++ + L + +E L+ E+ N++ +F +L++E
Sbjct: 2537 REDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEE 2596
Query: 718 NQEPLKTLEEEDQSI------VRPLETEN-----HKSLRSLEEQDQETLRTLEKETQQRR 766
Q+ K +E SI V L+ E H L+ ++E++ L L +Q+R
Sbjct: 2597 KQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK-VKEEEVHRLSALFSSSQKRI 2655
Query: 767 RSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEA-VKSLETEI 825
L E+ L + +E A+ + + K LK +A + ETE
Sbjct: 2656 AELEEE---------------LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETET 2700
Query: 826 LESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLE 885
E + E L E + + T E N+G L +IQ S+ Q +
Sbjct: 2701 AEERVA---ELARDLVEMEQKLLMVTKE--NKG----LTAQIQSFGRSMSSLQNSRDHAN 2751
Query: 886 EENQESLRSLGA--WNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQE-L 942
EE E R A L L+ +++E L E + SL LE+ Q+ L
Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
Query: 943 PQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEE 993
+ + +E Q MA ++NE + N E + F EE
Sbjct: 2812 SKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN--ELEKFRKSEE 2860
Score = 58.2 bits (139), Expect = 7e-08
Identities = 96/421 (22%), Positives = 166/421 (39%), Gaps = 69/421 (16%)
Query: 533 EIQDSQVPLEKETLKSLGEEIQESLKTLENQSH---------ETLERENQECPRSLEEDL 583
E+++ V ++KE K +GE + K L++ H ET E E R L E
Sbjct: 2657 ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEME 2716
Query: 584 ETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNL 643
+ L + KENK L ++ ++ L+ + + L L+++ +K L
Sbjct: 2717 QKLLMVTKENKGLTAQIQSFG----RSMSSLQNSRDHANEELDELKRKYDASLKELAQLK 2772
Query: 644 ETFLFPGTENQELVS-------SLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKEN 696
E L E L+S S +EN SL+ LEK NQ+ L E + + N
Sbjct: 2773 EQGLL-NRERDALLSETAFSMNSTEEN--SLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN 2829
Query: 697 Q-----EPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQD 751
Q + + SL++E + LEK + Q P E ++ K S + D
Sbjct: 2830 QVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQND 2889
Query: 752 QETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFL---- 807
++ L K QQ+ + + ++T P K L+ + + E QE L
Sbjct: 2890 RDRLLKELKNLQQQYLQINQ--EITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQH 2947
Query: 808 ----------------KSLKEESVEAVKSLETE------ILESLKSAG------------ 833
+ +KE+ + A+ + + ++ L+S+
Sbjct: 2948 ELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQR 3007
Query: 834 QENLETLKSPETQAPLWTPEEINQGAMNPLEKEI-QEPLESVEVNQETFRLLEEENQESL 892
Q + ET SP+ L E+ + +N KEI Q+ L ++N +LLEE+N S+
Sbjct: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSI 3067
Query: 893 R 893
+
Sbjct: 3068 Q 3068
Score = 54.7 bits (130), Expect = 7e-07
Identities = 215/1094 (19%), Positives = 397/1094 (36%), Gaps = 182/1094 (16%)
Query: 7 EESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSA--DTSWRAHADDELAALR 64
EE M + + E +++ ++A Q + A +R + A +T R H +DEL L
Sbjct: 183 EEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLH-EDELLQLV 241
Query: 65 ALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARA 124
D + V + L E E + GR Q + L ++ T RN+
Sbjct: 242 TQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQI---------- 291
Query: 125 WLSSQVAELERELEALR----VAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELAR 180
LS Q+ ++E E LR EE ++ L + E
Sbjct: 292 -LSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFE 350
Query: 181 RLGEAWRGAVRGY----QERVAHME--TSLGQARERLGRAVQGAREG-RLELQQLQAERG 233
+ G+A Y Q+ A ME TS + ++ G+ +Q A + + + +L ++
Sbjct: 351 QAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKN 410
Query: 234 GLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKM 293
+ A Q+LE + Q++ + +F L L+Q + Q+ V Q +
Sbjct: 411 EQAVQSAQTIQQLEDQLQQKSKEISQF-LNRLPLQQHETASQTSFPDVYNEGTQAVTEEN 469
Query: 294 SLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSP 353
SL+ + ++E EN + G +S+ ++ K E +L S + +L
Sbjct: 470 IASLQ----KRVVELENEK----GALLLSSIELEELKAE--------NEKLSSQITLLEA 513
Query: 354 TSLPSPLPATLETPVPAFLKNQEFLQARTP---TLASTPIPPTPQAPSPAVDAEIRAQDA 410
+ + + N+ A L +T + ++ + ++
Sbjct: 514 QNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEI 573
Query: 411 PLSLLQTQGGRKQAPE----------PLRAEARVAIPASV-----------LPGPEE--P 447
LQ QG R + + + E I V +P E P
Sbjct: 574 AFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLP 633
Query: 448 GGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVE- 506
++++AST E + + +S + + +E K + G + S G+ L
Sbjct: 634 AVEKEQAST----EHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERL 689
Query: 507 KETAIEGKVVSSLQQEIWEEE-DLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSH 565
K +E ++ QEI+E+ D KEI + L + I+E K +N S
Sbjct: 690 KSQILELELNFHKAQEIYEKNLDEKAKEISN------------LNQLIEEFKKNADNNSS 737
Query: 566 E-TLERENQECPRSLEEDLETLKSLEKENKEL---LKDVEVVRPLEKEA----------- 610
T E ++ S ++L + L + K+L L + E R L+ E+
Sbjct: 738 AFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQ 797
Query: 611 VGQLKPTGKEDTQTLQSLQKENQE----------LMKSLEGNL---ETFLFPGTENQELV 657
+ L K ++ LQ E + L++SL+ L E+ + G E +
Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857
Query: 658 SSLQENLE---SLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSL 714
SS E L S LE + L + D E L+ +E + + + E L
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 715 EKEN----------QEPLKTLEEEDQSIVRPLETENHKSLRSLEEQD------------- 751
+E +E L L +++ +E +N S + D
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 752 QETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLK 811
Q L+KE +QR+R L + L K L Q ++R LE E L +LK
Sbjct: 978 QHEFDLLKKENEQRKRKL------------QAALINRKELLQRVSR-LEEE----LANLK 1020
Query: 812 EESVEAVKSLETEILESLKSAGQENLE------TLKSPETQAPLWTPEEINQGAMNPLEK 865
+ES + + ETE E +EN E T K E + L + + + K
Sbjct: 1021 DESKKEIPLSETERGE--VEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRK 1078
Query: 866 EIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGK 925
+++E L + E Q + + + Q+ + E + + K N + +
Sbjct: 1079 DLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138
Query: 926 GEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQ 985
+E++ P + + W+ +E+ + +E E E +L + Q
Sbjct: 1139 ALVKETVVI------SPPCTGSSEHWKPELEEK----------ILALEKEKE-QLQKKLQ 1181
Query: 986 DGFTGKEEVVEQGE 999
+ T ++ ++++ +
Sbjct: 1182 EALTSRKAILKKAQ 1195
Score = 35.8 bits (81), Expect = 0.35
Identities = 27/101 (26%), Positives = 48/101 (47%), Gaps = 3/101 (2%)
Query: 198 AHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRAT 257
A ++ L Q RE L + + + +L ++Q ++ LE + A +LE + +E A
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYA---KLEEKLKESEEAN 2583
Query: 258 EKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLE 298
E + + AL++EKQ L +I + QL +L E
Sbjct: 2584 EDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEE 2624
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 90.5 bits (223), Expect = 1e-17
Identities = 284/1291 (21%), Positives = 499/1291 (38%), Gaps = 207/1291 (16%)
Query: 30 EEQNELLSAELGGLRAQSADTSWRAHADD--ELAALRALVDQRWREK----HAAEVAR-- 81
E + L +L LR ++ D + +AH D E+ LR+ + REK H+ +VA+
Sbjct: 560 ESERRALEEQLQRLRDKT-DGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQ 618
Query: 82 -DNLAEELEGVAGRCQQLRLARERTTEEV-------ARNRRAVEAEKCARAWLSSQVAEL 133
+ L +E E + ++LR R+R EE AR RR +E L + + L
Sbjct: 619 AEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVL 678
Query: 134 ERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVE-ELARRLGEAWRGAVRG 192
+EL +R A R L A + A A VE EL+ A +++
Sbjct: 679 AKELVEVREALS--RATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736
Query: 193 YQERVAHMETSLGQARERLGRAVQGAREGRLELQ--QLQAERGGLLERRAALEQRLEGRW 250
+++ + SL Q + L R V E + LQ Q QAE+ + R ++RLE
Sbjct: 737 SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREE--QERLEELR 794
Query: 251 QERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAEN 310
E+ A + + ++ EQ ++ L+ Q+ + R QL LS +++ LE
Sbjct: 795 LEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQAR 854
Query: 311 SRLQTP------GGGSKTSLSFQDPKLELQFPRTP-EGRRL---------------GSLL 348
Q K +L+ + L +Q EGR L GSL
Sbjct: 855 REAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF 914
Query: 349 PVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQ 408
V + LE A L +E L L I +A ++D E+ AQ
Sbjct: 915 EVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA---SLDKELMAQ 971
Query: 409 DAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAP 468
L+Q + ++A LR E R A + E +EA+ + + A L
Sbjct: 972 ----KLVQAE---REAQASLR-EQRAAHEEDLQRLQRE-----KEAAWRELEAERAQLQS 1018
Query: 469 PLSPDHSSLEAK---DGESGGSRVFSICRGEGEGQIWGLVEKE----------TAIEGKV 515
L + L A+ + E + ++ + EG + EK+ TA+ K+
Sbjct: 1019 QLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKL 1078
Query: 516 VS--------SLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQES-------LKTL 560
+ SL+ E + + +R+E S V L+ L + +E+ ++ L
Sbjct: 1079 MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
Query: 561 ENQSHETLERENQECPRSLEEDLETLKSLEK----------ENKELLKDVEVVRPLEKEA 610
+ Q+ + L ++ C R EE L+ LE E + L++ + R ++++
Sbjct: 1139 QEQARD-LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQE 1197
Query: 611 VGQLKPTGKEDTQTLQSLQKENQEL---MKSLEGNLETFLFPGTENQELVSSLQENLESL 667
G+L+ + E + ++L++ N+EL +K E + + ++ ++ L+E ++
Sbjct: 1198 AGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAV 1257
Query: 668 TALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSL------------- 714
E + L+ E EA R L +E + ++ L+ EN R L
Sbjct: 1258 GKEAGELRTGLQEVERSRLEARREL-QELRRQMKMLDSENTRLGRELAELQGRLALGERA 1316
Query: 715 EKENQEPLKTLEE---EDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGE 771
EKE++ L + + ++ + + E + R L+EQ+ E RT E RR LG
Sbjct: 1317 EKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGE-FRTRE------RRLLGS 1369
Query: 772 QDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEES-----------VEAVKS 820
++ R EK L+ + L+ ++ + L+ E VE +
Sbjct: 1370 LEE--ARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR 1427
Query: 821 LETEILESLKSAGQENLETLKSPETQAPLWTP---------EEINQGAMNPLEKEIQEPL 871
L L+SA + L ++P + AP P E +G +P E
Sbjct: 1428 AAEAQLGGLRSALRRGLGLGRAP-SPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGS 1486
Query: 872 ESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPE--------------------EVDK 911
+ T + + E++R L+ LRS + E ++
Sbjct: 1487 QPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAER 1546
Query: 912 ESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAG 971
+S + + E +E+ RS+ +G+ A++ E++V + + + + +A
Sbjct: 1547 DSATSRARQLQKAVAESEEARRSV--DGRLSGVQAELALQEESVRRSERERRATLDQVAT 1604
Query: 972 VENEDEA-ELNLREQDGFTGKEEVVE---QGELNATEEVWIPGEGHPESPEPKEQRGLVE 1027
+E +A E LR K + E +G+ +EV E E QR +E
Sbjct: 1605 LERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLE--LQRRSLE 1662
Query: 1028 GASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVED-DVAPGGDQASPEVMLG- 1085
G ++ GL D E Q+ QA Q ++++ V D +V G Q + E + G
Sbjct: 1663 G-ELQRSRLGLSDREAQA--------QALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA 1713
Query: 1086 ------SEPAMGESAAGAEPGPGQGVGGLGDPG----HLTREEVM---EPPLEEESLEAK 1132
SE A+ + G Q L HL + + + +E L+A
Sbjct: 1714 LAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAA 1773
Query: 1133 RVQGLEGPRKDLEEAGGLGTEFSELPGKSRD 1163
R Q L RK ++ LG + L G+ D
Sbjct: 1774 R-QALSEARK---QSSSLGEQVQTLRGEVAD 1800
Score = 87.4 bits (215), Expect = 1e-16
Identities = 212/963 (22%), Positives = 386/963 (40%), Gaps = 138/963 (14%)
Query: 36 LSAELGGLRAQSADTSWRAHADDEL--------------AALRALVDQRWREKHAAEVAR 81
L++EL LRAQ + + AHA + + LR + R + E AR
Sbjct: 1113 LTSELRDLRAQREEAA-AAHAQEVRRLQEQARDLGKQRDSCLREAEELR-TQLRLLEDAR 1170
Query: 82 DNLAEELEGVAGRCQQLRLARERTTEEVARNRRAV-------EAEKCARAWLSSQVAELE 134
D L EL + ++ + RE +E RR++ EA + + L S V + E
Sbjct: 1171 DGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAE 1230
Query: 135 RELEALRVAHE--EERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRG 192
E +L++A+E E+++ L +A A E EL L E R +
Sbjct: 1231 SERISLKLANEDKEQKLALLEEARTAV------------GKEAGELRTGLQEVERSRLEA 1278
Query: 193 YQE--RVAHMETSLGQARERLGRAVQGAREGRLEL-----QQLQAERGGLLERRAALEQR 245
+E + L RLGR + +GRL L ++ + E GL +R E
Sbjct: 1279 RRELQELRRQMKMLDSENTRLGREL-AELQGRLALGERAEKESRRETLGLRQRLLKGEAS 1337
Query: 246 LEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVL-EGRQQLAHLK-MSLSLEVATYR 303
LE QE A K Q ++ L + + +QQL H + + L LE A
Sbjct: 1338 LEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAE 1397
Query: 304 TLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPAT 363
AE + G L + ++E+Q R +LG L L
Sbjct: 1398 A---AELGLRLSAAEGRAQGLEAELARVEVQ--RRAAEAQLGGLRSAL------------ 1440
Query: 364 LETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQ 423
+ R P+ A P+P +P +PA + ++P +L + G +
Sbjct: 1441 ----------RRGLGLGRAPSPAPRPVPGSPARDAPA-EGSGEGLNSPSTLECSPGSQPP 1489
Query: 424 APEPLRAEARVAIPASVLPGPEEPGGQRQE-----ASTGQSPEDHASLAPPLSPDHSSLE 478
+P P + PAS PE G +E S + ++ + L+ + +E
Sbjct: 1490 SPGPATS------PASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEME 1543
Query: 479 AKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEI-WEEEDLNRKEIQD- 536
A + +S SR + + E + E +++G++ S +Q E+ +EE + R E +
Sbjct: 1544 A-ERDSATSRARQLQKAVAESE-----EARRSVDGRL-SGVQAELALQEESVRRSERERR 1596
Query: 537 ---SQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKS----L 589
QV + +L++ E++ S + + + E + R L+E L+ +S L
Sbjct: 1597 ATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDK--RRLKEVLDASESRTVKL 1654
Query: 590 EKENKELLKDVEVVRP--LEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFL 647
E + + L +++ R ++EA Q ++ +LQ +++ +L+ +E
Sbjct: 1655 ELQRRSLEGELQRSRLGLSDREAQAQAL---QDRVDSLQRQVADSEVKAGTLQLTVERLN 1711
Query: 648 FPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLT--KENQEPLRSLED 705
+ +E +L++ + LT ++ L S + + LT + +++ L+ D
Sbjct: 1712 GALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLD 1771
Query: 706 ENKEAFRSLEKENQ---EPLKTLEEEDQSI-VRPLETENH-----KSLRSLEEQDQETLR 756
++A K++ E ++TL E + ++ +E E + LR +E + L
Sbjct: 1772 AARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALN 1831
Query: 757 TLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVE 816
T++K Q RR L Q+++ LE K + A LE + ++L + E
Sbjct: 1832 TVQK-LQDERRLL--QERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVERE 1888
Query: 817 AVKSLETEILESLKSAGQENLET---LKSPETQAPLWTPEE---INQGAMNPLEKEIQEP 870
++S E + S + + T L+ E Q + E + + + +P + E+
Sbjct: 1889 KLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ 1948
Query: 871 LESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQE 930
+ +E+ QE E LRS A L + E ++ R LEE+ + KG+ Q+
Sbjct: 1949 QQQLELQQEV---------ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQ 1999
Query: 931 SLR 933
LR
Sbjct: 2000 ELR 2002
Score = 85.9 bits (211), Expect = 3e-16
Identities = 251/1098 (22%), Positives = 407/1098 (37%), Gaps = 221/1098 (20%)
Query: 15 LNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAH-ADDELAALRALVDQRWRE 73
L L+ + + L ++ E L A LR Q A + A +R +++ R+
Sbjct: 608 LAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQ 667
Query: 74 KHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAEL 133
E R LA+EL V + L R+ E A A+ + R L + +L
Sbjct: 668 LEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKL 727
Query: 134 ERE----------LEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLG 183
E L AL + ++++ LN A + +G A + +AR
Sbjct: 728 RAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVARE-- 785
Query: 184 EAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQ----LQAERGGLLERR 239
QER+ + AR+ L +++ A + + L+Q L+ ER L E+
Sbjct: 786 ---------EQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQL 836
Query: 240 AALEQRLEGRWQERLRATEKFQLAVEALE---QEKQGLQSQIAQVLEGRQQLAHLKMSLS 296
A L ++L GR QE +A + Q VEALE +EK+ L ++ A L + L
Sbjct: 837 AQLSRQLSGREQELEQARREAQRQVEALERAAREKEAL----------AKEHAGLAVQLV 886
Query: 297 LEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSL 356
RTL E T L + LE GSL V +
Sbjct: 887 AAEREGRTLSE------------EATRLRLEKEALE------------GSLFEVQRQLAQ 922
Query: 357 PSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQ 416
LE A L +E L L I +A ++D E+ AQ L+Q
Sbjct: 923 LEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKA---SLDKELMAQ----KLVQ 975
Query: 417 TQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSS 476
+ ++A LR E R A + E +EA+ + + A L L +
Sbjct: 976 AE---REAQASLR-EQRAAHEEDLQRLQRE-----KEAAWRELEAERAQLQSQLQREQEE 1026
Query: 477 LEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQD 536
L A+ +E E + +++LQQE +E L E +
Sbjct: 1027 LLAR------------------------LEAEKEELSEEIAALQQE--RDEGLLLAESEK 1060
Query: 537 SQVPLEKETLK-SLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKE 595
Q KE+ K +L E++ + +L S E +ER+ ++ E+D T+ +L E ++
Sbjct: 1061 QQALSLKESEKTALSEKLMGTRHSLATISLE-MERQKRDAQSRQEQDRSTVNALTSELRD 1119
Query: 596 LLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQE 655
L R +EA Q ++ LQ++ ++L K + L E +E
Sbjct: 1120 L-------RAQREEAAA-------AHAQEVRRLQEQARDLGKQRDSCLR-------EAEE 1158
Query: 656 LVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLE 715
L + L+ ++ L +E E R +E+QE E E RSL
Sbjct: 1159 LRTQLRLLEDARDGLRRELLEAQRK------------LRESQEGREVQRQEAGELRRSLG 1206
Query: 716 K--ENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQD 773
+ + +E L+ EE +S V+ E+E SL+ E ++ L LE+ + GE
Sbjct: 1207 EGAKEREALRRSNEELRSAVKKAESE-RISLKLANEDKEQKLALLEEARTAVGKEAGEL- 1264
Query: 774 QMTLRPPEKVDLEPLKSLDQEIARP---LENENQEFLKSLKEESVEAVKSLETEILESLK 830
+ L+ E+ LE + L QE+ R L++EN + L E L+ + +
Sbjct: 1265 RTGLQEVERSRLEARREL-QELRRQMKMLDSENTRLGRELAE--------LQGRLALGER 1315
Query: 831 SAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQE 890
+ + ETL + + ++ + +E+Q ++ + FR E
Sbjct: 1316 AEKESRRETLGLRQRLLK-------GEASLEVMRQELQVAQRKLQEQEGEFRTRER---- 1364
Query: 891 SLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQE-SLRSLEEEGQELPQSADVQ 949
R LG +LE R E+ + R LE + + E E LR EG+ A++
Sbjct: 1365 --RLLG--SLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELA 1420
Query: 950 RWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIP 1009
R VE + A EA+L G + +G
Sbjct: 1421 R----VEVQRRAA--------------EAQLG--------GLRSALRRG----------L 1444
Query: 1010 GEGHPESPEPKEQRGL-VEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVE 1068
G G SP P+ G A +G EGL P S +PG Q P P
Sbjct: 1445 GLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSP---STLECSPGSQPPSPGPA------- 1494
Query: 1069 DDVAPGGDQASPEVMLGS 1086
+P PE + G+
Sbjct: 1495 --TSPASPDLDPEAVRGA 1510
Score = 53.9 bits (128), Expect = 1e-06
Identities = 106/521 (20%), Positives = 224/521 (42%), Gaps = 60/521 (11%)
Query: 498 EGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESL 557
E + +EK+ ++ ++ L+ ++ E+DL ++++Q L+K L + E+ ++
Sbjct: 350 ESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSD---LDKADLSARVTELGLAV 406
Query: 558 KTLENQSHETLERENQECPRSLEEDLETLK-----SLEKENKELLKDV--EVVRPLEKEA 610
K LE Q+ E ++ N++ LE LE+L+ +LE E+ E L+ ++ + + ++
Sbjct: 407 KRLEKQNLEK-DQVNKDLTEKLEA-LESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDS 464
Query: 611 VGQLKPTGKEDTQ-----TLQSL--QKENQELMKSLEG---NLETFLFPGTENQELVSSL 660
++ +G E T +L+ L Q+ +S G + P + ++ +
Sbjct: 465 ESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALI 524
Query: 661 -------QENLESLTALEKENQEPLRS--PEVGDEEALRPLTKENQEPLRSLEDENKEAF 711
Q ++ + + +Q+ L + ++ D E+ R +E + LR D +A
Sbjct: 525 HSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAH 584
Query: 712 RSLEKENQ---EPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRS 768
++E Q + L E ++ L+ ++ Q++E L+ ++E +++R
Sbjct: 585 EDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEEL--RQEREKLQAAQEELRRQRDR 642
Query: 769 LGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKE-ESVEAVKSLETEILE 827
L E+ + ++ +V E +S Q LE + K L E + +L+ ++L+
Sbjct: 643 LEEEQEDAVQDGARVRRELERSHRQ--LEQLEGKRSVLAKELVEVREALSRATLQRDMLQ 700
Query: 828 SLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETF------ 881
+ K+ E L ++ + E++ + E +Q+ L + E+
Sbjct: 701 AEKAEVAEALTKAEAGRVEL------ELSMTKLRAEEASLQDSLSKLSALNESLAQDKLD 754
Query: 882 --RLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEE---EENLGKGEYQESLRSLE 936
RL+ + +E G V +E Q LEE E+ + + + SLR E
Sbjct: 755 LNRLVAQLEEEKSALQG--RQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAE 812
Query: 937 EEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDE 977
+ + L Q R E + + ++LAQ S ++G E E E
Sbjct: 813 QAQEALEQQLPTLRHERS-QLQEQLAQLSRQ-LSGREQELE 851
Score = 53.1 bits (126), Expect = 2e-06
Identities = 166/788 (21%), Positives = 304/788 (38%), Gaps = 118/788 (14%)
Query: 14 ELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQRWRE 73
E R L+ ++K L+ +N L EL L+ + A RA + L L + +
Sbjct: 1277 EARRELQELRRQMKMLDSENTRLGRELAELQGRLA-LGERAEKESRRETL-GLRQRLLKG 1334
Query: 74 KHAAEVARDNLA------EELEG--------VAGRCQQLRLARERTTEEVARNRRAVEAE 119
+ + EV R L +E EG + G ++ R ++ + +EA
Sbjct: 1335 EASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAA 1394
Query: 120 KCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAP---------------RCPAP 164
+ A L +++ E + L E RV + +AA A R P+P
Sbjct: 1395 RAEAAELGLRLSAAEGRAQGLEA--ELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSP 1452
Query: 165 PRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLG------------ 212
P +P + A GE + +E S G G
Sbjct: 1453 APRPVPGSPARDAPAEGSGEGLNSP--------STLECSPGSQPPSPGPATSPASPDLDP 1504
Query: 213 RAVQGA-REGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEK---FQLAVEALE 268
AV+GA RE EL+ Q ER L + +AL ++L ER AT + Q AV E
Sbjct: 1505 EAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESE 1564
Query: 269 QEKQ-------GLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSK 321
+ ++ G+Q+++A E ++ + + +VAT L+A S L+
Sbjct: 1565 EARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQATESELRA-SQEKI 1623
Query: 322 TSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPLPA-TLETPVPAFLKNQEFLQA 380
+ + + KLE + RRL +L ++ L +LE + +A
Sbjct: 1624 SKMKANETKLE------GDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREA 1677
Query: 381 RTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEP---LRAEARVAIP 437
+ L D+E++A L++ + G + E LR + R
Sbjct: 1678 QAQALQDR----VDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTE 1733
Query: 438 ASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSP-DHSSLEAKDGESGGSRVFSICRGE 496
A + AS + + + L L+ +H ++ + S R
Sbjct: 1734 ALA----------QSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEAR-- 1781
Query: 497 GEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQES 556
K+++ G+ V +L+ E+ + E L R E + Q+ +E L+ E +
Sbjct: 1782 ----------KQSSSLGEQVQTLRGEVADLE-LQRVEAE-GQLQQLREVLRQRQEGEAAA 1829
Query: 557 LKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKP 616
L T++ E R QE SL+ L LE E +E+ + LEK+ V +
Sbjct: 1830 LNTVQKLQDE--RRLLQERLGSLQR---ALAQLEAEKREVERSA---LRLEKDRVALRRT 1881
Query: 617 TGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQ-ENLESLTALEKENQ 675
K + + L+S E+ + + +G L+ L G E + + Q + LE+ + +++
Sbjct: 1882 LDKVEREKLRS--HEDTVRLSAEKGRLDRTL-TGAELELAEAQRQIQQLEAQVVVLEQSH 1938
Query: 676 EPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRP 735
P + ++ L ++ E LRS + + + + E+ +++ ++ LEE+ ++
Sbjct: 1939 SPAQLEVDAQQQQLE--LQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQ 1996
Query: 736 LETENHKS 743
L+ E +S
Sbjct: 1997 LQQELRRS 2004
Score = 45.1 bits (105), Expect = 6e-04
Identities = 114/507 (22%), Positives = 199/507 (39%), Gaps = 91/507 (17%)
Query: 551 EEIQESLKT-LENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKE 609
+E++ +L+T ++ L +E R L +D + + SL +E+ V R L +
Sbjct: 9 QEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQ-ITSLPALIREI-----VTRNLSQP 62
Query: 610 AVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELV---SSLQENLES 666
L P + +L SLQ+ENQ L + L + E EL +++ E LE
Sbjct: 63 ESPVLLPA--TEMASLLSLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQ 120
Query: 667 LTALEK---ENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLE--KENQEP 721
LE E QEP R L +++ E R L++E R L+ +E Q+
Sbjct: 121 ALRLEPGELETQEP------------RGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQR 168
Query: 722 LKTL----------------EEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQR 765
L E E Q + R E E + + QD E+ +E QQR
Sbjct: 169 QAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESALIRLEEEQQR 228
Query: 766 RRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKE-ESVEAVKSLETE 824
SL + + M + L+ S +Q ++ + ++ + KE E EA E E
Sbjct: 229 SASLAQVNAML-----REQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEE 283
Query: 825 ILESLKSAGQENLETL-------KSPETQAPLWTPEEINQ--GAMNPLEKEIQEP----- 870
+ S L L + ++ ++T ++ Q G + + +QE
Sbjct: 284 SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLS 343
Query: 871 -----LES-VEVNQETFRLLEEENQESLRS--LGAWNLENLRSPEEVDKE---------- 912
ES E E LL+ + +E LR L +L + ++DK
Sbjct: 344 TGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELG 403
Query: 913 ------SQRNLEEEE-NLGKGEYQESLRSLEEEGQELPQSADVQRWEDTV-EKDQELAQE 964
++NLE+++ N E E+L SL + Q ++ D + + T+ + Q + +
Sbjct: 404 LAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSD 463
Query: 965 SPPGMAGVENEDEAELNLREQDGFTGK 991
S G+ +E A+ + G +G+
Sbjct: 464 SESGVQLSGSERTADASNGSLRGLSGQ 490
Score = 41.6 bits (96), Expect = 0.006
Identities = 70/309 (22%), Positives = 125/309 (40%), Gaps = 74/309 (23%)
Query: 15 LNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSW-RAHADDELAALRALVDQRWRE 73
L RL+A + +Q+ L ++ LR + AD R A+ +L LR ++ R+
Sbjct: 1766 LQERLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL----RQ 1821
Query: 74 KHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAEL 133
+ E A N ++L+ + RL +ER + R +EAE
Sbjct: 1822 RQEGEAAALNTVQKLQ------DERRLLQERLGS-LQRALAQLEAE-------------- 1860
Query: 134 ERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGY 193
+RE+E + E++RV L R L + R +R +
Sbjct: 1861 KREVERSALRLEKDRVALR---------------------------RTLDKVEREKLRSH 1893
Query: 194 QERVAHMETSLGQARERLGRAVQGAR----EGRLELQQLQAERGGLLERRAALEQRLEGR 249
++ V L + RL R + GA E + ++QQL+A+ L + + + ++ +
Sbjct: 1894 EDTV-----RLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQ 1948
Query: 250 WQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLE--VATYRTLLE 307
Q QL ++ + + Q+Q + LE R++ AH + LE V+T + L+
Sbjct: 1949 QQ---------QLELQQEVERLRSAQAQTERTLEARER-AHRQRVRGLEEQVSTLKGQLQ 1998
Query: 308 AENSRLQTP 316
E R P
Sbjct: 1999 QELRRSSAP 2007
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 90.1 bits (222), Expect = 2e-17
Identities = 204/972 (20%), Positives = 407/972 (41%), Gaps = 134/972 (13%)
Query: 58 DELAALRALVDQRWRE--KHAAEVAR--DNLAEELEGVAGRCQQLRLARER---TTEEVA 110
DEL + +V Q K E++R D LAE E + + QQL+ +++ EE++
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151
Query: 111 RNRRAVEAEKCARAWLSSQVAELER-ELEALRVAHEEERVGLNAQAACAPRCPAPPRGPP 169
++ + + + L ++ LE E E L +A + ++ R
Sbjct: 1152 EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKER--------- 1202
Query: 170 APAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQ 229
+V + ++ E R +RGY + +E + Q +E L A +E + + +L
Sbjct: 1203 ----KVLKELQKSFETERDHLRGY---IREIEATGLQTKEELKIAHIHLKEHQETIDEL- 1254
Query: 230 AERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQS--QIAQVLEGRQQ 287
R + E+ A + Q+ ++ K Q + L +E++ L + ++++ E +
Sbjct: 1255 --RRSVSEKTAQIINT-----QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE 1307
Query: 288 LAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSL 347
L L + + +T +E E RL FQ+ + E++ T E L ++
Sbjct: 1308 LELLTEQSTTKDSTTLARIEMERLRLNE---------KFQESQEEIK-SLTKERDNLKTI 1357
Query: 348 LPVLSPT--SLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEI 405
L L + TL + K ++ L + +T I + P A +
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417
Query: 406 RAQDAPLSLLQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHAS 465
R + + +L +++ + +++ A+ L + + + + + H
Sbjct: 1418 RIE---IEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLE 1474
Query: 466 LAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWE 525
L H L+ ++ RV E E +I + ++ AI K+ + +Q+ +
Sbjct: 1475 TEEELKVAHCCLKEQEETINELRVNL---SEKETEISTIQKQLEAINDKLQNKIQEIYEK 1531
Query: 526 EEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLET 585
EE N K+I + Q + + LK E + L++ + LE N+ L+E E
Sbjct: 1532 EEQFNIKQISEVQEKVNE--LKQFKEHRKAKDSALQSIESKMLELTNR-----LQESQEE 1584
Query: 586 LKSLEKENKELLKDVEVVRPLE--------KEAVGQLKPTGKEDTQTLQ-SLQKENQELM 636
++ + KE KE +K V+ +E KE V ++K + +++ Q L+ + E QE M
Sbjct: 1585 IQIMIKE-KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKM 1643
Query: 637 KSLEGNLETFLFPG-------TENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEAL 689
+E E F TEN L L ENLE + ++ KE ++ LRS E
Sbjct: 1644 CEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE-RDDLRSVE------- 1695
Query: 690 RPLTKENQEPLRSLEDENKEAFR---SLEKENQEPLKT----LEEEDQSIVRPLETENHK 742
E L+ D+ KE R + + E QE LK L+E ++I
Sbjct: 1696 --------ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETI---------D 1738
Query: 743 SLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENE 802
LR + + + ++K+ + +L QD L+ E++ + + +Q+ E
Sbjct: 1739 KLRGIVSEKTNEISNMQKDLEHSNDALKAQD---LKIQEELRIAHMHLKEQQ-------E 1788
Query: 803 NQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNP 862
+ L+ + E + + +++ + LE+ + QE ++ LK+ E Q + +++N+
Sbjct: 1789 TIDKLRGIVSEKTDKLSNMQKD-LENSNAKLQEKIQELKANEHQL-ITLKKDVNE--TQK 1844
Query: 863 LEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEEN 922
E+++ + ++ T LE EN + L NLE ++S + ++++ R +EE
Sbjct: 1845 KVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHE-NLEEMKSVMK-ERDNLRRVEETLK 1902
Query: 923 LGKGEYQESLRSLEEEGQELPQSADVQRW-----EDTVEKDQELAQESPPGMAGVE---- 973
L + + +ESL+ + E+ Q R ++TV+K +E E ++ ++
Sbjct: 1903 LERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD 1962
Query: 974 -NEDEAELNLRE 984
++DE + ++E
Sbjct: 1963 KSKDELQKKIQE 1974
Score = 63.5 bits (153), Expect = 2e-09
Identities = 81/366 (22%), Positives = 165/366 (45%), Gaps = 49/366 (13%)
Query: 503 GLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPL---------EKETLKSLGEEI 553
G+V ++T +S++Q+++ D + + Q L ++ET+ L +
Sbjct: 1742 GIVSEKT----NEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIV 1797
Query: 554 QESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQ 613
E L N + LE N + L+E ++ LK+ E + L KDV + E + Q
Sbjct: 1798 SEKTDKLSNMQKD-LENSNAK----LQEKIQELKANEHQLITLKKDVNETQKKVSE-MEQ 1851
Query: 614 LKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQEL----------VSSLQEN 663
LK K+ + TL L+ EN L + L NLE E L L+E+
Sbjct: 1852 LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES 1911
Query: 664 LESLTALEKENQEPLRSPEV---GDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQE 720
L+ A + E Q+ L++ + +E + L ++ E + D K+ +S + E Q+
Sbjct: 1912 LQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKS-KDELQK 1970
Query: 721 PLKTLEEEDQSIVRPLETEN--HKSLRSLEEQDQE------TLRTLEKETQQRRRSLGEQ 772
++ L++++ ++R E N HK + +E+ ++ +++++ + Q + L E
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 773 -DQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKS 831
+++ + E+ +L +K L+ E +F+ +L+E ++ + + + L S
Sbjct: 2031 LEEIRIVAKERDELRRIK-------ESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS 2083
Query: 832 AGQENL 837
GQ++L
Sbjct: 2084 DGQQHL 2089
Score = 62.4 bits (150), Expect = 3e-09
Identities = 111/488 (22%), Positives = 216/488 (44%), Gaps = 64/488 (13%)
Query: 511 IEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHE---- 566
+EGK+ + LQ+E+ +E + N E +V L E LKSL E++ K ++++S E
Sbjct: 718 LEGKI-TDLQKELNKEVEEN--EALREEVILLSE-LKSLPSEVERLRKEIQDKSEELHII 773
Query: 567 TLEREN----------------QECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEA 610
T E++ +E ++ ++DL T +S K + ++ + + ++
Sbjct: 774 TSEKDKLFSEVVHKESRVQGLLEEIGKT-KDDLATTQSNYKSTDQEFQNFKTLHMDFEQK 832
Query: 611 VGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFL-FPGTENQELVSSLQENLESLTA 669
+ + Q + +L KE Q+ SL G L+T L + E QE +QE L +
Sbjct: 833 YKMVLEENERMNQEIVNLSKEAQKFDSSL-GALKTELSYKTQELQEKTREVQERLNEMEQ 891
Query: 670 LEK--ENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEE 727
L++ EN++ ++ + ++ E +++L E K+ + L++ Q L+
Sbjct: 892 LKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE-KDDLKQLQESLQIERDQLKS 950
Query: 728 EDQSIVRPLETENHKSLRSLEE---QDQETLRTLE-KETQQRRRSLGEQDQMTLRPPEKV 783
+ V + + + LR+ E Q QET+ TL+ K +++ R+L M E
Sbjct: 951 DIHDTVN-MNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNL----HMEENTGETK 1005
Query: 784 DLEPLKSLDQEIARPLENENQEFLKS--LKEESVEAVKSLETEILESLKSAGQENLETLK 841
D K + + + LE +N + L + E +E + + + I E K+ Q+ LE++
Sbjct: 1006 DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQE--KNELQQMLESVI 1063
Query: 842 SPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLE 901
+ + Q L+ +++E +E NQE RLL +E ++ +
Sbjct: 1064 AEKEQ----------------LKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNH 1107
Query: 902 NLRSPEEVDKESQRNLEEEENLGK-----GEYQESLRSLEEEGQELPQSADVQRWEDTVE 956
++ E+ + R E EE L + E Q+ L +++EE E+ + +
Sbjct: 1108 AIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNEL 1167
Query: 957 KDQELAQE 964
K++EL E
Sbjct: 1168 KNKELTLE 1175
Score = 62.0 bits (149), Expect = 5e-09
Identities = 131/587 (22%), Positives = 257/587 (43%), Gaps = 97/587 (16%)
Query: 544 ETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVV 603
E K + ++++ L++ N+ + + + P+ L +LE + KEL K+VE
Sbjct: 677 EAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN 736
Query: 604 RPLEKEAV--GQLKPTGKEDTQTLQSLQKENQEL-------------MKSLEGNLETFLF 648
L +E + +LK E + + +Q +++EL + E ++ L
Sbjct: 737 EALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE 796
Query: 649 PGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENK 708
+ ++ +++ Q N +S T E +N + L + E+ + + +EN+ + + + +K
Sbjct: 797 EIGKTKDDLATTQSNYKS-TDQEFQNFKTL---HMDFEQKYKMVLEENERMNQEIVNLSK 852
Query: 709 EAFR------SLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKE- 761
EA + +L+ E + L+E+ + + L E + LE +D TL+T+E+E
Sbjct: 853 EAQKFDSSLGALKTELSYKTQELQEKTREVQERL-NEMEQLKEQLENRD-STLQTVEREK 910
Query: 762 ---TQQRRRSLGEQDQMT--------LRPPEKVDLEPLKS-----------LDQEIARPL 799
T++ +++L E +T L+ +++ + LKS +++ L
Sbjct: 911 TLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNAL 970
Query: 800 EN--ENQEFLKSLKEESVEAV--------KSLETEILESLKSAGQENLETLKSPETQ--- 846
E+ ++QE + +LK + E V + ET+ K G + + L++ TQ
Sbjct: 971 ESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLT 1030
Query: 847 APLWTPEEINQG----AMNPLEKEIQEPLESVEVNQETFRL-LEE------ENQESLRSL 895
A + E I Q ++ + E+Q+ LESV +E + L+E ENQE LR L
Sbjct: 1031 ADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLL 1090
Query: 896 GAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTV 955
G + L+ +E+ + + + ++E GE + L E ++L + + +
Sbjct: 1091 G----DELKKQQEIVAQEKNHAIKKE----GELSRTCDRLAEVEEKLKEKS-----QQLQ 1137
Query: 956 EKDQEL--AQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGH 1013
EK Q+L QE M NE E NL+ + KE +E E E E +
Sbjct: 1138 EKQQQLLNVQEEMSEMQKKINEIE---NLKNE--LKNKELTLEHMETERLELAQKLNENY 1192
Query: 1014 PESPEPKEQRGLVEGASVKGGAEGLQDP-EGQSQQVGAPGLQAPQGL 1059
E ++R +++ ++ E +D G +++ A GLQ + L
Sbjct: 1193 EEVKSITKERKVLK--ELQKSFETERDHLRGYIREIEATGLQTKEEL 1237
Score = 51.6 bits (122), Expect = 6e-06
Identities = 85/432 (19%), Positives = 181/432 (41%), Gaps = 67/432 (15%)
Query: 527 EDLNRKEIQ-DSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLET 585
E LNR + + ++ +KE S+ + SL L+ + E L NQ C ++
Sbjct: 2115 ECLNRLSLDLEKEIEFQKEL--SMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKK 2172
Query: 586 LKSL--------EKENKELLK-DVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELM 636
LK + E++++ + K +++ + +EK+ +K + + S + + +L
Sbjct: 2173 LKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLN 2232
Query: 637 KSLEGNLETFL-------FPG--TENQELVSSLQENLESL--------------TALEKE 673
++++ ++E L FP TE Q+++S+ +E + L ++KE
Sbjct: 2233 QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292
Query: 674 NQE-------------PLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQE 720
N + + EE ++KE ++ L+SL+++N++ F+ N +
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFK-----NYQ 2347
Query: 721 PLKTLEEEDQSIVRPLETENHKSLRSLEEQ-DQETLRTLEKETQQRRRSLGEQDQMTLRP 779
LKT + + + + S Q E +R LE + + S ++ ++
Sbjct: 2348 TLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKM 2407
Query: 780 PEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLET 839
+++++ +I L+ + E K L E++ E ++ L+ ++ K +E +E
Sbjct: 2408 QKELEVT------NDIIAKLQAKVHESNKCL-EKTKETIQVLQDKVALGAKPY-KEEIED 2459
Query: 840 LKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWN 899
LK + L + + EKEI +VE +E RLL E + S ++
Sbjct: 2460 LKMKLVKIDLEKMKNAKE-----FEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSV 2514
Query: 900 LENLRSPEEVDK 911
+ P+ +K
Sbjct: 2515 ISEHTDPQPSNK 2526
Score = 50.4 bits (119), Expect = 1e-05
Identities = 75/309 (24%), Positives = 140/309 (45%), Gaps = 28/309 (9%)
Query: 651 TENQELVSSLQE--NLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENK 708
TE +E+ L+E +L+ ALE++ ++ + + L+ L K + + LE+E
Sbjct: 519 TEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELS 578
Query: 709 EAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRS 768
L ++ + K E D + ++ + SL S+E+ Q + ET +
Sbjct: 579 SKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETV----A 634
Query: 769 LGEQDQMTLRPPEKVDL-EPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILE 827
L + + E ++L E +K L + +EN+ Q L + +EA K ++ ++ +
Sbjct: 635 LDAKRESAFLRSENLELKEKMKEL-ATTYKQMENDIQ-----LYQSQLEAKKKMQVDLEK 688
Query: 828 SLKSAGQE--NLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLE 885
L+SA E L +L + L E+ +G + L+KE+ + +E E +E LL
Sbjct: 689 ELQSAFNEITKLTSLIDGKVPKDLLCNLEL-EGKITDLQKELNKEVEENEALREEVILLS 747
Query: 886 EENQESLRSLGAWNLENLRSPEEVDKESQRNL---EEEENLGKGEYQESLRS--LEEEGQ 940
E L+SL + +E LR E DK + ++ E+++ + ++ES LEE G+
Sbjct: 748 E-----LKSLPS-EVERLRK-EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800
Query: 941 ELPQSADVQ 949
A Q
Sbjct: 801 TKDDLATTQ 809
Score = 32.0 bits (71), Expect = 5.0
Identities = 32/118 (27%), Positives = 53/118 (44%), Gaps = 4/118 (3%)
Query: 201 ETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKF 260
++SLG + L Q +E E+Q+ E L E+ + L+ +E+ TEK
Sbjct: 858 DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKL 917
Query: 261 QLAVE---ALEQEKQGL-QSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQ 314
Q +E L QEK L Q Q + +E Q + + ++++ + T L A S Q
Sbjct: 918 QQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ 975
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 89.4 bits (220), Expect = 3e-17
Identities = 130/522 (24%), Positives = 226/522 (43%), Gaps = 58/522 (11%)
Query: 476 SLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQ 535
SLE E + S+ + E EG++ GL+++ E K+ + + EE L K+ +
Sbjct: 854 SLEITLKEKHQKELLSL-KNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNE 912
Query: 536 DSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKE 595
+ V EKE + L E + L +EN H + E +E +S E LE LK L EN E
Sbjct: 913 FALVKHEKEAVICLQNEKDQKLLEMENIMH-SQNCEIKELKQSREIVLEDLKKLHVENDE 971
Query: 596 LLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQE 655
L+ + LQSL+ Q +K LE L+ QE
Sbjct: 972 KLQLLRA---------------------ELQSLE---QSHLKELEDTLQV-----RHIQE 1002
Query: 656 LVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENK-----EA 710
+ ++ SL L+KENQ+ + + E ++ K+ QE + D + E
Sbjct: 1003 FEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEV 1062
Query: 711 FRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLG 770
+L++ + +K L EE ++ + ++L+SL EQ+ E LRT + Q+ +
Sbjct: 1063 ELALKEAETDEIKILLEESRA-------QQKETLKSLLEQETENLRTEISKLNQKIQDNN 1115
Query: 771 EQDQMTLRPPEK-VDLEPLKSLDQEIARPLENEN-----QEFLKSLKEESVEAVKSLETE 824
E Q+ L + +E + + + I+R E N + SL ++ E K+L+ +
Sbjct: 1116 ENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQ 1175
Query: 825 ILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLL 884
I+E L+S L L+ + + + EE + + LEK+ Q+ + S E ++E +L+
Sbjct: 1176 IIE-LQSKLDSELSALERQKDE-KITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE--QLI 1231
Query: 885 EEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEEN-LGKGEYQESLR----SLEEEG 939
++ N E ++ E E V+KE ++ EN + K +S R SL E
Sbjct: 1232 QKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAEL 1291
Query: 940 QELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELN 981
QE Q + E E+++ +E + E + N
Sbjct: 1292 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFN 1333
Score = 73.9 bits (180), Expect = 1e-12
Identities = 97/443 (21%), Positives = 193/443 (43%), Gaps = 60/443 (13%)
Query: 516 VSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQ-------ESLKTLENQSHETL 568
+ L E E+ L R E+Q LE+ LK L + +Q E + T S E L
Sbjct: 962 LKKLHVENDEKLQLLRAELQS----LEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEEL 1017
Query: 569 ERENQECPRSLEED-LETLKSLEKENKEL-------------------LKDVEV--VRPL 606
++ENQ+ ++E E ++ EK+ +EL LK+ E ++ L
Sbjct: 1018 KKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKIL 1077
Query: 607 EKEAVGQLKPTGKEDT-QTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLE 665
+E+ Q K T K Q ++L+ E +L + ++ N E + E + L++ ++
Sbjct: 1078 LEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCI 1137
Query: 666 SLTALEKENQEPLRSPEVGDEEALR----PLTKENQEPLRSLEDENKEAFRSLEKENQEP 721
S E + + E+ +L + K +E + L+ + +LE++ E
Sbjct: 1138 SELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEK 1197
Query: 722 LKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPE 781
+ EE+ ++I++ LE + K + S E+ ++ ++ L E + ++ ++ ++ E
Sbjct: 1198 ITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVE 1257
Query: 782 KVDLEPLKSLDQEIARPLENEN---------QEFLKSLKEESVEAVKSLETEILESLKSA 832
K LE +K L+ +IA+ ++ E + L+EE + ++ LE + E K+
Sbjct: 1258 KELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQ--EKRKNE 1315
Query: 833 GQENLETLKSPETQA---PLWTPEEI-NQGAMNPLEKEIQEPLESVEVNQETFRLLEEEN 888
+N+ T E Q + T E++ + +N L +++ ++ E +++ L E+
Sbjct: 1316 EMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR 1375
Query: 889 QESLRSLGAWNLENLRSPEEVDK 911
L E + EEV K
Sbjct: 1376 ARLLE-------EKKKLEEEVSK 1391
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 89.4 bits (220), Expect = 3e-17
Identities = 130/522 (24%), Positives = 226/522 (43%), Gaps = 58/522 (11%)
Query: 476 SLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQ 535
SLE E + S+ + E EG++ GL+++ E K+ + + EE L K+ +
Sbjct: 854 SLEITLKEKHQKELLSL-KNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNE 912
Query: 536 DSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKE 595
+ V EKE + L E + L +EN H + E +E +S E LE LK L EN E
Sbjct: 913 FALVKHEKEAVICLQNEKDQKLLEMENIMH-SQNCEIKELKQSREIVLEDLKKLHVENDE 971
Query: 596 LLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQE 655
L+ + LQSL+ Q +K LE L+ QE
Sbjct: 972 KLQLLRA---------------------ELQSLE---QSHLKELEDTLQV-----RHIQE 1002
Query: 656 LVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENK-----EA 710
+ ++ SL L+KENQ+ + + E ++ K+ QE + D + E
Sbjct: 1003 FEKVMTDHRVSLEELKKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEV 1062
Query: 711 FRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLG 770
+L++ + +K L EE ++ + ++L+SL EQ+ E LRT + Q+ +
Sbjct: 1063 ELALKEAETDEIKILLEESRA-------QQKETLKSLLEQETENLRTEISKLNQKIQDNN 1115
Query: 771 EQDQMTLRPPEK-VDLEPLKSLDQEIARPLENEN-----QEFLKSLKEESVEAVKSLETE 824
E Q+ L + +E + + + I+R E N + SL ++ E K+L+ +
Sbjct: 1116 ENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQ 1175
Query: 825 ILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLL 884
I+E L+S L L+ + + + EE + + LEK+ Q+ + S E ++E +L+
Sbjct: 1176 IIE-LQSKLDSELSALERQKDE-KITQQEEKYEAIIQNLEKDRQKLVSSQEQDRE--QLI 1231
Query: 885 EEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEEN-LGKGEYQESLR----SLEEEG 939
++ N E ++ E E V+KE ++ EN + K +S R SL E
Sbjct: 1232 QKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGDSSSLVAEL 1291
Query: 940 QELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELN 981
QE Q + E E+++ +E + E + N
Sbjct: 1292 QEKLQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFN 1333
Score = 73.9 bits (180), Expect = 1e-12
Identities = 97/443 (21%), Positives = 193/443 (43%), Gaps = 60/443 (13%)
Query: 516 VSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQ-------ESLKTLENQSHETL 568
+ L E E+ L R E+Q LE+ LK L + +Q E + T S E L
Sbjct: 962 LKKLHVENDEKLQLLRAELQS----LEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEEL 1017
Query: 569 ERENQECPRSLEED-LETLKSLEKENKEL-------------------LKDVEV--VRPL 606
++ENQ+ ++E E ++ EK+ +EL LK+ E ++ L
Sbjct: 1018 KKENQQIINQIQESHAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKIL 1077
Query: 607 EKEAVGQLKPTGKEDT-QTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLE 665
+E+ Q K T K Q ++L+ E +L + ++ N E + E + L++ ++
Sbjct: 1078 LEESRAQQKETLKSLLEQETENLRTEISKLNQKIQDNNENYQVGLAELRTLMTIEKDQCI 1137
Query: 666 SLTALEKENQEPLRSPEVGDEEALR----PLTKENQEPLRSLEDENKEAFRSLEKENQEP 721
S E + + E+ +L + K +E + L+ + +LE++ E
Sbjct: 1138 SELISRHEEESNILKAELNKVTSLHNQAFEIEKNLKEQIIELQSKLDSELSALERQKDEK 1197
Query: 722 LKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPE 781
+ EE+ ++I++ LE + K + S E+ ++ ++ L E + ++ ++ ++ E
Sbjct: 1198 ITQQEEKYEAIIQNLEKDRQKLVSSQEQDREQLIQKLNCEKDEAIQTALKEFKLEREVVE 1257
Query: 782 KVDLEPLKSLDQEIARPLENEN---------QEFLKSLKEESVEAVKSLETEILESLKSA 832
K LE +K L+ +IA+ ++ E + L+EE + ++ LE + E K+
Sbjct: 1258 KELLEKVKHLENQIAKSPAIDSTRGDSSSLVAELQEKLQEEKAKFLEQLEEQ--EKRKNE 1315
Query: 833 GQENLETLKSPETQA---PLWTPEEI-NQGAMNPLEKEIQEPLESVEVNQETFRLLEEEN 888
+N+ T E Q + T E++ + +N L +++ ++ E +++ L E+
Sbjct: 1316 EMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKLKSTMQQQERDKDLIESLSEDR 1375
Query: 889 QESLRSLGAWNLENLRSPEEVDK 911
L E + EEV K
Sbjct: 1376 ARLLE-------EKKKLEEEVSK 1391
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 89.4 bits (220), Expect = 3e-17
Identities = 125/570 (21%), Positives = 253/570 (44%), Gaps = 63/570 (11%)
Query: 498 EGQIWGLVEKETAIEGKVVSSLQQEIWEEED-LNRKEIQDSQVPLEKETLKSLGEE--IQ 554
E ++W EK+ + + + ++ +WE+++ L KE + + E ++ + EE +Q
Sbjct: 375 EERLWEQ-EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQ 433
Query: 555 ESLKTLENQSHETLEREN-QECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQ 613
E K +Q + E E +E + + E+ ET++ E+E K ++ + EKE Q
Sbjct: 434 EQEKKTRDQEEKMQEEERIREREKKMREEEETMR--EQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 614 LKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKE 673
P KE + +Q++ +++ + E + G QE QE + E
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG---QEKKMWRQEKMREQEDQMWE 548
Query: 674 NQEPLRSPEV---GDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQ 730
+E +R E EE + T+E ++ E++ +E R E+E K + EE++
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRERE-----KKMREEEE 603
Query: 731 SIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKS 790
++R E + + ++EQ +E + E++ Q++ + EQ++ EK+ +
Sbjct: 604 -MMREQEEKMQEQEEKMQEQ-EEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ---- 657
Query: 791 LDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLW 850
+ L + ++ + K + E ++ E +I E QE +E K+ E + W
Sbjct: 658 ------QRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE------QEKMEK-KTQEQEKKTW 704
Query: 851 TPEEI-NQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNL-ENLRSPEE 908
E++ + +M EK+++E E + +E + EE+ QE + W E + EE
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEM--WEQEEKMWEQEE 762
Query: 909 VDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPG 968
E QR E++E L + E + + E+ +++ + R ++ + QE
Sbjct: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE------EK 816
Query: 969 MAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEG 1028
M G E E +++ G+EE + E E++W E E + +E++ +
Sbjct: 817 MRGQE-----EKMWGQEEKMWGQEEKMWGQE----EKMWGQEEKMEEKMQGQEEKMREQE 867
Query: 1029 ASVKGGAEGLQDPE----GQSQQ---VGAP 1051
++G E +++ E GQ ++ VG+P
Sbjct: 868 EKMRGQEEKMREQEEKMRGQEEKIYCVGSP 897
Score = 79.0 bits (193), Expect = 4e-14
Identities = 159/777 (20%), Positives = 304/777 (39%), Gaps = 106/777 (13%)
Query: 521 QEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLE 580
+E+ +E D E+ + + E LK E+QE L E++ E ++ +E R LE
Sbjct: 200 EELTKERDALSLELYRNTIT--NEELKKKNAELQEKLPLAESEKSE-IQLNVKELKRKLE 256
Query: 581 EDLETLKSLEKEN--KELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKS 638
L ++ +E+ + E +R EK+ Q + +++ E ++
Sbjct: 257 RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE------------ERLRE 304
Query: 639 LEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQE 698
EG + E +E + ++ L EKE +E + E+ +++ LR ++ QE
Sbjct: 305 QEGKMR-------EQEEKMWRQEKRLREQ---EKELRE--QEKELREQKELREQEEQMQE 352
Query: 699 PLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTL 758
+ ++ ++ EK ++ + E+E Q +R E + + EQD+ R
Sbjct: 353 QEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ--MREQEQKMRDQEERMWEQDE---RLR 407
Query: 759 EKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAV 818
EKE + R + + +R +K+ + K+ DQE E +E K ++EE E +
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEE-ETM 466
Query: 819 KSLETEIL---ESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVE 875
+ E ++ E++ ++ + + PE + LW E+ M E++I E E +
Sbjct: 467 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK-----MQEQEEKIWEQEEKIR 521
Query: 876 VNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNL-EEEENLGKGEYQESLRS 934
+E + QE W E +R E+ E + + ++E+ + E + ++
Sbjct: 522 DQEEMW------GQEK----KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571
Query: 935 LEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEV 994
E+E + Q ++ E E+++++ +E E E E ++EQ+ E++
Sbjct: 572 QEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE-----EKM 626
Query: 995 VEQGE--LNATEEVWIPGEGHPESPEPK-EQRGLVEGASVKGGAEGLQDPEGQSQQVGAP 1051
EQ E E++W E E E EQ+ L E E +Q+ E +Q
Sbjct: 627 WEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKI 686
Query: 1052 GLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDP 1111
Q E +E ++ DQ + E +M E + +
Sbjct: 687 WEQ------EKMEKKTQEQEKKTWDQEK----MREEESMREREK-----------KMREE 725
Query: 1112 GHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREG 1171
+ RE+ + +EE ++ + + E K E+ + E LP + WE +
Sbjct: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKM-WEQQRLPEQKEKLWEHEKMQ 784
Query: 1172 REE---SEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPI 1228
+E + E R EE G EE +
Sbjct: 785 EQEKIWEQEEKMRDQEEKM-----------------RGQEEKMRGQEEKMRGQEEKMWGQ 827
Query: 1229 LEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEESREE 1285
E G + + G +E WG + + E K++ ++E++ E QEE +EE
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEE--KMQGQEEKMREQEEKMRGQEEKMREQEE 882
Score = 57.4 bits (137), Expect = 1e-07
Identities = 82/398 (20%), Positives = 164/398 (41%), Gaps = 61/398 (15%)
Query: 496 EGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQE 555
E E Q+W EK + +Q++W++E+ K+ Q+ EK+T E+++E
Sbjct: 541 EQEDQMWEQEEK--------MRDQEQKMWDQEERMEKKTQEQ----EKKTWDQ-EEKMRE 587
Query: 556 SLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLK 615
+ E E RE +E R EE ++ + +E +E + + E ++E + + +
Sbjct: 588 EERMRE---REKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644
Query: 616 PTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQ 675
E + + Q+ ++ K E + QE + +E + +EK+ Q
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLWE-------HEKMQEQEKMQEQEEKIWEQEKMEKKTQ 697
Query: 676 EPLRSPEVGDEEALRPLTKENQEPLRSLED---ENKEAFRSLEKENQEPLKTLEEEDQSI 732
E + + D+E +R +E +R E E +E R E++ QE + ++E+++ +
Sbjct: 698 E--QEKKTWDQEKMR-----EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEM 750
Query: 733 VRPLET--ENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKS 790
E E + + + ++ + E E Q + + EQ++ EK+ + K
Sbjct: 751 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKM 810
Query: 791 LDQEIARPLENENQEFLKSLKEESVEAVKSLETEIL-ESLKSAGQENLETLKSPETQAPL 849
QE E ++ E ++ + K GQE K + +
Sbjct: 811 RGQE---------------------EKMRGQEEKMWGQEEKMWGQEE----KMWGQEEKM 845
Query: 850 WTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEE 887
W EE + M E++++E E + +E R EE+
Sbjct: 846 WGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEK 883
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 88.6 bits (218), Expect = 5e-17
Identities = 256/1122 (22%), Positives = 399/1122 (35%), Gaps = 178/1122 (15%)
Query: 525 EEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLE 584
E+E E Q + LE+ ++ EE+Q +T E E L+ E + E+ +
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGEGLQEEAVQL-----EETK 1326
Query: 585 TLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLE 644
T + L++E +L + E ++E QL+ + + LQ + +E+ + EG L+
Sbjct: 1327 TEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386
Query: 645 -TFLFPGTENQELVSSL----QENLESLTALEKENQE--PLRSPEVGDEEA-LRPL---- 692
L G + + L QE E+ + K +QE P++ E G A P
Sbjct: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
Query: 693 TKENQEPLRSLEDENKEAFRSLEKENQE------PLKTLEEEDQSIVRPLETENHKSLRS 746
T+E EP L + + A E P T+ ++ + +P + +S
Sbjct: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSV 1506
Query: 747 ----------------LEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKS 790
L++ ++ L L + R G QD L +
Sbjct: 1507 ACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLD-------QMAAE 1559
Query: 791 LDQEIARPLENENQEFLKSLKEESVEAV-----KSLETEILESLKSA-----GQENLETL 840
L Q++A+ L++ + L+ L+ + V ++L E+L + G NL
Sbjct: 1560 LQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAF 1619
Query: 841 KSPETQ-APLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWN 899
PL E L ++ E E E + ++ + S ++
Sbjct: 1620 SERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGAT 1679
Query: 900 LENLRSPEEVDKESQRNLEEEENLGKGEYQE-----------SLRSLEEE----GQELPQ 944
++ ++ + QR E + GE E S R+++ G L Q
Sbjct: 1680 RGPIKEAFDLQQILQRKRGEHTD---GEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQ 1736
Query: 945 SADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATE 1004
V ED E Q L ++ P + E + A+ E++G T E EL E
Sbjct: 1737 GPGVDEGEDG-EGSQRLNRDKDPKLGEAEGDAMAQ----EREGKTHNSETSAGSELGEAE 1791
Query: 1005 EVWIPGEGHPESPEPKEQ-RGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEA- 1062
+ GEG E E Q G + + A G QDP GQS GA G++AP+ EA
Sbjct: 1792 Q---EGEGISERGETGGQGSGHEDNLQGEAAAGGDQDP-GQSD--GAEGIEAPEAEGEAQ 1845
Query: 1063 -----IE-PLVEDDVAPGGDQASPEVMLGSEP-AMGESAAGAEPGPGQGVGGLGDP---G 1112
+E P E D +A PE P A GE+ +E P G
Sbjct: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
Query: 1113 HLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSR------DPWE 1166
E E E ES+EA +G + P + EA E G+++ + E
Sbjct: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
Query: 1167 PPREGREESE------------------------AEAPRGAEEAFPAETLGHTGSDAPSP 1202
E + ESE EAP E AE SD
Sbjct: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA 2025
Query: 1203 WPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGS------QEASWGVQGRAEAL 1256
P E ++V P + P+ + E QEA +E +
Sbjct: 2026 QPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDV 2085
Query: 1257 GKVESEQEELGSGEIPEGPQEEGEESREESEE--DELGETLPDS----TPLGFYLRSPTS 1310
E+E E E E P+ EGE + E E + GE P+S P P S
Sbjct: 2086 DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPES 2145
Query: 1311 P---RWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSE 1367
D GE +P +G +E + A EG+EAP +E E E E +++
Sbjct: 2146 EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEA 2205
Query: 1368 EFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEE------ 1421
+ E G EAP E E P+ + P A +GE+ ++ E GE+
Sbjct: 2206 QPELEGVEAP-------EAEEEAQPEPEGVETPEA---EGEAQPESEGETQGEKKGSPQV 2255
Query: 1422 --GEEDQEEGRE-------------PGAGRWGPGSSVGSLQALSSSQR---GEFLESDSV 1463
G+ EE E P G P GS SSS+ G + DS
Sbjct: 2256 SLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSE 2315
Query: 1464 SVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEEESDPV 1505
+ V D A + A ++ E S SE+E P+
Sbjct: 2316 NDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPL 2357
Score = 84.0 bits (206), Expect = 1e-15
Identities = 151/580 (26%), Positives = 224/580 (38%), Gaps = 72/580 (12%)
Query: 1070 DVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPG-HLTREEVMEPPLEEES 1128
+VAPG P + A G G GPG G G+ L R++ +P L E
Sbjct: 1707 EVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDK--DPKLGEAE 1764
Query: 1129 LEAKRVQGLEGPRKDLEEAGG--LGTEFSELPGKS-RDPWEPPREGREES-EAEAPRGAE 1184
+A Q EG + E + G LG E G S R G E++ + EA G +
Sbjct: 1765 GDA-MAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGD 1823
Query: 1185 EAFPAETLGHTGSDAP------SPWPLGSE--EAEEDVPPVLVSPSP----TYTPILEDA 1232
+ P ++ G G +AP P G E EAE D P P E
Sbjct: 1824 QD-PGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE 1882
Query: 1233 PGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGE----------ES 1282
P+ + + EA W VQ +E E+E+E E E + EGE +
Sbjct: 1883 AQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQE 1942
Query: 1283 REESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGET-GKEGWDPAVLASEG 1341
EE+ ++ G+T P+S + P E + E +E A SE
Sbjct: 1943 AEEAAQEAEGQTQPESEVIE---SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESED 1999
Query: 1342 LEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPA 1401
+EAP +E E +E EEE +SD G EA P GE A+ + Q A
Sbjct: 2000 VEAPEAEGEM-QEAEEEAQPESD--------GVEAQ--PKSEGEEAQEVEGETQKTEGDA 2048
Query: 1402 AWDRDGESDGFADEEESGEEGEEDQEEGR----------EPGAGRWGPGS-SVGSLQALS 1450
+ DG A+EE EGE + EG + G P S V + +A
Sbjct: 2049 QPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEG 2108
Query: 1451 SSQRGEFLES-DSVSVSVPWDDSLRG--AVAGAPKTALETESQDS---AEPSGSEEESDP 1504
+Q+ E +E+ ++ + P + + A A + E+QD+ A+P E+
Sbjct: 2109 EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE 2168
Query: 1505 VSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVG 1564
E + ++ G +E P +A P ++ I + P EG++Q GV ++EE
Sbjct: 2169 AEEEAQPELEG-VEAPEAEGEAQPESEGI----EAPEAEGEAQPELEGV--EAPEAEEEA 2221
Query: 1565 QGMP--LVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQ 1602
Q P + + G E EG V LG GQ
Sbjct: 2222 QPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQ 2261
Score = 62.0 bits (149), Expect = 5e-09
Identities = 122/530 (23%), Positives = 187/530 (35%), Gaps = 117/530 (22%)
Query: 1118 EVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEA 1177
EV + + VQG EG GLG S+ PG D E + +
Sbjct: 1707 EVAPGKTHTDPTSTRTVQGAEG---------GLGPGLSQGPGV--DEGEDGEGSQRLNRD 1755
Query: 1178 EAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQP 1237
+ P+ E A G S GSE E + ++ G
Sbjct: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE----------------QEGEGISE 1799
Query: 1238 QAEGSQEASW---GVQGRAEALGKVESEQEELGSG-EIPEG-----PQEEGEESRE---E 1285
+ E + S +QG A A G + Q + G E PE P+ EG E+ E +
Sbjct: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
Query: 1286 SEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASEGLEAP 1345
++E E GE P+S + + P +GE E D +E P
Sbjct: 1860 AQEAE-GEAQPESEDV-----------------EAPEAEGEAQPESEDVETPEAEWEVQP 1901
Query: 1346 PSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDR 1405
SE E E E+E +++ E E G + P G + AE AA +
Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE-----------EAAQEA 1950
Query: 1406 DGESDGFADEEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGE-FLESDSVS 1464
+G++ ++ ES E EE Q E + V +L+ +Q E + +S
Sbjct: 1951 EGQTQPESEVIESQEAEEEAQPESED-----------VEALEVEVETQEAEGEAQPESED 1999
Query: 1465 VSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSL-EREDKVPGPLEIPSGM 1523
V P G + E+++ A+P E+ P S E +V G + G
Sbjct: 2000 VEAP---EAEGEM---------QEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEG- 2046
Query: 1524 EDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNG----------LEQSEEVGQGMPLVSEG 1573
DA P +D + + P E ++Q G V ++ E G+ P
Sbjct: 2047 -DAQPESDGV----EAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQP----E 2097
Query: 1574 DRGSPFQEEEGSALKTSWAGAPVHLGQGQ----FLKFTQREGDRESWSSG 1619
G E EG A K AP G+ Q ++ + EG+ + S G
Sbjct: 2098 SEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEG 2147
Score = 53.5 bits (127), Expect = 2e-06
Identities = 98/434 (22%), Positives = 162/434 (37%), Gaps = 61/434 (14%)
Query: 423 QAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLS----PDHSSLE 478
+APE AE + + PE G QEA PE AP P+ +E
Sbjct: 1836 EAPE---AEGEAQPESEGVEAPEAEG-DAQEAEGEAQPESEDVEAPEAEGEAQPESEDVE 1891
Query: 479 AKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQ 538
+ E + E EG EKE E + V +L+ E +E + E Q+++
Sbjct: 1892 TPEAEWE-------VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
Query: 539 VPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLK 598
E + + Q + +E+Q E + E +LE ++ET + E E + +
Sbjct: 1945 -----EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET-QEAEGEAQPESE 1998
Query: 599 DVEVVRPLEKEAVGQLKPTGKE---DTQTLQSLQKENQELMKSLEGNLETFLFPGTENQE 655
DVE EA G+++ +E ++ +++ K E + +EG E Q+
Sbjct: 1999 DVEA-----PEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEG----------ETQK 2043
Query: 656 LVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLE 715
Q + + A E E + EV + E E ++ + E E
Sbjct: 2044 TEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEG------EAHPESEDVDAQEAEGEAQPE 2097
Query: 716 KENQE-PLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQ 774
E E P E + + ETE S + E E E Q + QD
Sbjct: 2098 SEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEA----EGEAQPESEGVEAQDA 2153
Query: 775 MTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAG- 833
PE +E A+ E E Q L+ ++ E E+E +E+ ++ G
Sbjct: 2154 EGEAQPESEGIE---------AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGE 2204
Query: 834 -QENLETLKSPETQ 846
Q LE +++PE +
Sbjct: 2205 AQPELEGVEAPEAE 2218
Score = 50.4 bits (119), Expect = 1e-05
Identities = 173/769 (22%), Positives = 269/769 (34%), Gaps = 179/769 (23%)
Query: 934 SLEEEGQELPQSADVQRWED-TVEKDQELAQE---------SPPGMAGVENEDEAELNLR 983
+L +G ELP QR + T E +L + + A NEDEAE +
Sbjct: 1222 TLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSE 1281
Query: 984 EQDGFTGKEE-----VVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKG----- 1033
EQ + E+ V E+ +L T+E GEG E E+ EG +G
Sbjct: 1282 EQRASSNLEQLAENTVQEEVQLEETKE-GTEGEGLQEEAVQLEETKTEEGLQEEGVQLEE 1340
Query: 1034 ----GAEGLQDPEGQSQQV---GAPGLQ-----------APQG--LPEAIEP-LVEDDVA 1072
EG Q+ E Q +++ G GLQ P+G EA+E L E+ +
Sbjct: 1341 TKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLP 1400
Query: 1073 PGGDQASPEVMLGSEP--------------AMGESAAGAEPGPGQGVGGLGDPGHLTREE 1118
G E+ S P G ++A AEP P +G EE
Sbjct: 1401 EEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGT-----------EE 1449
Query: 1119 VMEPP--LEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESE 1176
EPP L E A Q LE+ G + + G+ +P + E S
Sbjct: 1450 PTEPPSHLSETDPSASERQSGSQLEPGLEKPPG-----ATMMGQEHTQAQPTQGAAERSS 1504
Query: 1177 AEAPRGA---------------EEAFPAETLGHTGSDAPSPWPLG--------SEEAEED 1213
+ A A E+AF A L ++ + W L + E ++D
Sbjct: 1505 SVACSAALDCDPIWVSVLLKKTEKAFLAH-LASAVAELRARWGLQDNDLLDQMAAELQQD 1563
Query: 1214 VPPVLVSPSPTYTPILEDAPG----PQPQAEGSQEASWGVQGRAEALGKVES----EQEE 1265
V L + L+ G P+ + E Q R L + + +
Sbjct: 1564 VAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERT 1623
Query: 1266 LGSGEIPEGPQEE-------GEESREESEEDELGETLPDSTPLGFYLR---SPTSPRWDP 1315
LG G + ++E G + EE+E +E P +R SP SP+
Sbjct: 1624 LGLGPLSFTLEDEPALSTALGSQLGEEAEGEEF-------CPCEACVRKKVSPMSPK-AT 1675
Query: 1316 TGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGR-DSDLSEEFEDLGT 1374
G R P KE +D + L+ E +GE E G+ +D + G
Sbjct: 1676 MGATRGPI-----KEAFD----LQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGA 1726
Query: 1375 EAPFLPGV---PGEVAEPLGQVPQLLL------------DPAAWDRDG------------ 1407
E PG+ PG G+ Q L D A +R+G
Sbjct: 1727 EGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSE 1786
Query: 1408 ------ESDGFADEEESGEE--GEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFL- 1458
E +G ++ E+G + G ED +G G PG S G+ + GE
Sbjct: 1787 LGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQP 1846
Query: 1459 ESDSVSVSVPWDDSLRGAVAGAPKT--ALETESQDSAEPSGSEEESDPVSLEREDKVPGP 1516
ES+ V D+ P++ E++ A+P + E+ E + + G
Sbjct: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG- 1905
Query: 1517 LEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQ 1565
E P ++A P + + + EG+ + + G +++EE Q
Sbjct: 1906 AEAPEAEKEAQPETESV----EALETEGEDEPESEGA--EAQEAEEAAQ 1948
Score = 45.8 bits (107), Expect = 3e-04
Identities = 152/660 (23%), Positives = 239/660 (36%), Gaps = 132/660 (20%)
Query: 915 RNLEEEENLGKG---EYQESLRSLEEEGQELPQS---ADVQRWEDTVEKDQ-----ELAQ 963
R L EE+ L G + QE + LP+S A V+ W D + ++ ELA
Sbjct: 920 RGLSEEKTLRSGGGPQGQEEASGVSPSS--LPRSSPEAVVREWLDNIPEEPILMTYELAD 977
Query: 964 ESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHP-ESPEPKEQ 1022
E+ G E + + G E + G+ + EG P + PEP
Sbjct: 978 ETTGAAGGGLRGPEVDPG--DDHSLEGLGEPAQAGQQSL--------EGDPGQDPEP--- 1024
Query: 1023 RGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEV 1082
EGA + G Q EG Q GA AP+G+ EA D AP G + S
Sbjct: 1025 ----EGALLGSSDTGPQSGEGVPQ--GA----APEGVSEAPAEAGADREAPAGCRVSLRA 1074
Query: 1083 MLGSEPAMGE---SAAGAEPGPGQGVGGLGDP----------GHLTREEVMEPPLEEESL 1129
+ G A + + G++ G V + P +T ++ E+
Sbjct: 1075 LPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGS 1134
Query: 1130 EAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPA 1189
A +V+ + PR + EL S+D W G + E + G E +
Sbjct: 1135 PASKVRFKDSPR------------YQELLSISKDLW----PGCDVGEDQLDSGLWELTWS 1178
Query: 1190 ETLGHTGSDAPSP--WPLGSE----------EAEEDVPPVLVSPSPTYTPILEDAPGPQP 1237
+ L GS A + P S E VP + T L Q
Sbjct: 1179 QALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQR 1238
Query: 1238 QAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEESREESEEDELGE-TLP 1296
+ E+ ++ + + + + + EE R S ++L E T+
Sbjct: 1239 PDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQ 1298
Query: 1297 DSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGK--EGWDPAVLASEGLEAPPSEKEEGEE 1354
+ L T + G Q Q E K EG L EG++ +++ EGE
Sbjct: 1299 EEVQL-----EETKEGTEGEGLQEEAVQLEETKTEEG-----LQEEGVQLEETKETEGEG 1348
Query: 1355 GEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFAD 1414
+EE ++ L EE E+ G E GV Q+ ++ P +G G A
Sbjct: 1349 QQEE---EAQL-EEIEETGGEGLQEEGV---------QLEEVKEGP-----EGGLQGEAL 1390
Query: 1415 EEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLR 1474
EE EEG ++ GS G + +SS G+ + D V +++ R
Sbjct: 1391 EEGLKEEGLPEE-------------GSVHGQELSEASSPDGKGSQEDD---PVQEEEAGR 1434
Query: 1475 GAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIG 1534
+ + P A TE + EP E+DP + ER+ ++ G+E PGA ++G
Sbjct: 1435 ASASAEPCPAEGTE--EPTEPPSHLSETDPSASERQ----SGSQLEPGLEKP-PGATMMG 1487
Score = 37.7 bits (86), Expect = 0.091
Identities = 86/344 (25%), Positives = 129/344 (37%), Gaps = 67/344 (19%)
Query: 1148 GGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGS 1207
G L T+ +ELP K+ + + P ES + + FP + A +
Sbjct: 1221 GTLVTQGTELPLKTSN--QRPDSRTYESPGDLENQQQCCFPTFLNARACACATN-----E 1273
Query: 1208 EEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEE-- 1265
+EAE D S + + E+ + Q E ++E + G + EA+ E++ EE
Sbjct: 1274 DEAERDSEEQRASSN--LEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331
Query: 1266 ------LGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQ 1319
L + EG ++ EE++ E E+ GE L + G L P G
Sbjct: 1332 QEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEE---GVQLEEVKE---GPEGGL 1385
Query: 1320 RPPPQGETGKEGWDPAVLASEGL--------EAPPSEKEEGEEG---EEECGRDSDLSEE 1368
QGE +EG L EG + P K E+ EEE GR S +E
Sbjct: 1386 ----QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEP 1441
Query: 1369 FEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEE 1428
GTE P P P ++ E+D A E +SG + E E
Sbjct: 1442 CPAEGTEEPTEP--PSHLS--------------------ETDPSASERQSGSQLEPGLE- 1478
Query: 1429 GREPGAGRWG-----PGSSVGSLQALSSSQRGEFLESDSVSVSV 1467
+ PGA G + G+ + SS L+ D + VSV
Sbjct: 1479 -KPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSV 1521
>gi|119220598 apolipoprotein B48 receptor [Homo sapiens]
Length = 1088
Score = 88.6 bits (218), Expect = 5e-17
Identities = 181/742 (24%), Positives = 269/742 (36%), Gaps = 139/742 (18%)
Query: 926 GEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMA-GVENEDEAELNLRE 984
G+ QE S E QE+ + ++ WE E+++ A+E PGMA G E+E
Sbjct: 154 GQAQERQESHE---QEVNREERLRSWEQEEEEEEVRARE--PGMARGAESEWTWHGETEG 208
Query: 985 QDGFTGK---------EEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGA 1035
+ G G E+ V + + TEE G G E +VE A A
Sbjct: 209 KAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVV------VVEKACESTRA 262
Query: 1036 EGLQDPEGQSQQVGAPGLQAPQGLP--EAIEPLVEDDVA---PGGDQASPEVMLGSEPAM 1090
G P + + G G + + P E +++ + A GG++A E G E A
Sbjct: 263 WGTWGPGAEPEDWGILGREEARTTPGREEARAILDGEEARTISGGEEA--ETASGGEEAE 320
Query: 1091 ----GESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEE 1146
GE A A G G+ G+ G + E E EA G E + +
Sbjct: 321 TASGGEEAGTASGGEEAGIASGGEAGTASGGE--EAGTASGGDEAWTTSGKE----EADL 374
Query: 1147 AGGLGTEFSELPGK-----SRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPS 1201
G TE+ +PG+ + W EG EE EAE FP +
Sbjct: 375 LGVRQTEYGAVPGERLLEATGKVWVLEEEGDEEREAEV-----SPFPKQ----------- 418
Query: 1202 PWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVES 1261
P LG+E EE ++ +A G QEA +G+ + GK
Sbjct: 419 PQVLGTERTEEAA----------------ESQTAGREAVGGQEAGESFEGQVDLRGKEAE 462
Query: 1262 EQEELGSGEIPEGPQE--EGEESREE--SEEDELGETLPDSTPLGFYLRSPTS---PRWD 1314
+++LG +E + EE++EE S D + E D G T P +
Sbjct: 463 MRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEE 522
Query: 1315 PTGEQRPPPQGETG-------------KEGWDPAVLASEGLEAPPSEKEEGEEGEEECGR 1361
TGE+ Q G +G P ++ G + P + EE E GE E
Sbjct: 523 LTGEESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMG--GAQTPTKQPEEREAGEVELMG 580
Query: 1362 DSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWD----RDGESDGFADEEE 1417
LS+E ++ EA P G V + P AW+ +D E ++
Sbjct: 581 VLALSKEEQERSLEAG--PRHAGSVKPEASEA-----FPGAWENRTRKDMERGNTQEDAA 633
Query: 1418 SGEEGEEDQEEGREPGAGRWGPGSSVGSL--------QALSSSQRGEFLESDSVSVSVPW 1469
GE+ EE++ G + A G L + L++ G E SVS
Sbjct: 634 DGEQREEEETAGGQTLAAE-AEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQ 692
Query: 1470 D-DSLRGAVAG---------APKTALETESQDSAEPSGSEEESDPVSL-EREDKVPGPL- 1517
+ D GA AG A +T E D G ++ V L +RED G +
Sbjct: 693 ELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSVA 752
Query: 1518 ------EIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQGMPLVS 1571
++ + AG G + GV GQG + + K + G G E E +
Sbjct: 753 AGIMGGDVVPHISAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTG 812
Query: 1572 EGDRGSPFQEEEGSALKTSWAG 1593
G + F+ EG W G
Sbjct: 813 RGSQVEAFESREGG----PWGG 830
Score = 60.8 bits (146), Expect = 1e-08
Identities = 166/717 (23%), Positives = 240/717 (33%), Gaps = 144/717 (20%)
Query: 959 QELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPE 1018
+E AQE G+ G +NE L G + E G +A E+ W G+G +
Sbjct: 60 EEEAQEDLEGLRGSQNEGAGRLR------GPGDDRRHEVGS-SAVEQTWGWGDGSSHGSQ 112
Query: 1019 PKEQ-RGLVEGASV----------------KGGAEGLQDPEGQSQQVGAPGLQAPQGLPE 1061
+ Q G E A K G+ QD GQ+Q+ + E
Sbjct: 113 AERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQE-RQESHEQEVNREE 171
Query: 1062 AIEPLVEDDVAPGGDQASPEVMLGSEP-------------AMGESAAGAEPGPGQGV--- 1105
+ +++ P + G+E A+G AAG QGV
Sbjct: 172 RLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKAGAVGPKAAGDNREMEQGVREA 231
Query: 1106 --GGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSEL-PGKSR 1162
G +PG + E + E++ E+ R G GP + E+ G LG E + PG+
Sbjct: 232 DAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGR-- 289
Query: 1163 DPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPS 1222
E R + EA G EEA A G EEAE
Sbjct: 290 ---EEARAILDGEEARTISGGEEAETAS---------------GGEEAET---------- 321
Query: 1223 PTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEES 1282
A G +EA G E G + SG G G+E+
Sbjct: 322 ----------------ASGGEEA--GTASGGEEAGIASGGEAGTASGGEEAGTASGGDEA 363
Query: 1283 REES---EEDELG--ETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVL 1337
S E D LG +T + P G L T W E + E P VL
Sbjct: 364 WTTSGKEEADLLGVRQTEYGAVP-GERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVL 422
Query: 1338 ASEGLEAPPSEKEEGEE--GEEECGRDSD--------LSEEFEDLGTEAPFLPGVPGEVA 1387
+E E + G E G +E G + +E +DLG A A
Sbjct: 423 GTERTEEAAESQTAGREAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQA 482
Query: 1388 EPLGQVPQLLLDPAA-WDRDGESDGFADEEESGEEGEEDQEEGREPGAGR---------W 1437
E + DP A DGE++G AD E + E E++ G E A + W
Sbjct: 483 EEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEW 542
Query: 1438 GPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSG 1497
G G +++ Q E + P ++ G V AL E Q+ + +G
Sbjct: 543 G-----GLTHSVTKGQGPELMGGAQTPTKQP-EEREAGEVELMGVLALSKEEQERSLEAG 596
Query: 1498 SEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGL 1557
+ V E + PG E + D+ N Q +G+ +
Sbjct: 597 -PRHAGSVKPEASEAFPGAWENRT-------RKDMERGNTQEDAADGEQRE--------- 639
Query: 1558 EQSEEVGQGMPLVSEGDRGSPFQ---EEEGSALKTSWAGAPVHLGQGQFLKFTQREG 1611
E+ GQ + +EGDR S E G L T AG G+ + + +G
Sbjct: 640 EEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDG 696
Score = 45.8 bits (107), Expect = 3e-04
Identities = 113/480 (23%), Positives = 164/480 (34%), Gaps = 98/480 (20%)
Query: 846 QAPLWTPEEINQGAMN-----PLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAW-- 898
Q P PEE G + L KE QE S+E ++ E E+ GAW
Sbjct: 562 QTPTKQPEEREAGEVELMGVLALSKEEQE--RSLEAGPRHAGSVKPEASEAFP--GAWEN 617
Query: 899 ----NLENLRSPEEVDKESQRNLEEEENLG--------KGEYQESLRSLEEEGQELPQSA 946
++E + E+ QR EEEE G +G+ + L + E G E +
Sbjct: 618 RTRKDMERGNTQEDAADGEQR--EEEETAGGQTLAAEAEGDRESELSEVPEAGGEGLTTQ 675
Query: 947 DV----QRWEDTVEKDQEL-----AQESPPGMAGVENEDEAELNLREQD----------- 986
D + E +V ++QEL A P G E E E D
Sbjct: 676 DAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAEADRTSRRGWRLQA 735
Query: 987 ---GFTGKEEV----VEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQ 1039
G +E+ V G + I G E+ E L +G K E
Sbjct: 736 VAVGLPDREDAQTGSVAAGIMGGDVVPHISAAGAGEALEGV----LGQGWDSKEKEEAAA 791
Query: 1040 DPEGQSQQVGAPGLQAPQ--GLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGA 1097
Q+ G G + G +E + P G + E G+E + G AG+
Sbjct: 792 GEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGGRVEAEESAGAEDSCGLDPAGS 851
Query: 1098 EPGPGQGVGGLGDPGHLTREEVMEPPLEEESL---EAKRVQGLEGPRKD----------L 1144
+ +G+G + + G L + + LEEE++ E ++ + EG D L
Sbjct: 852 QTARAEGMGAMVEAGGLLEKWTL---LEEEAVGWQEREQREDSEGRCGDYHPEGEAPRLL 908
Query: 1145 EEAGGLGTEFSELPGKSRDPWEPPR-EGREESEAE------APRGAEEAFPAETLGHTGS 1197
+ G + T K +P G+EE AP EA AE +G
Sbjct: 909 DAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSARG 968
Query: 1198 DAPSPW---PLGSEEAEEDVPPVLV-----------SPSPTYTPI---LEDAPGPQPQAE 1240
A + W PL + VP V PS TP E+ P P P E
Sbjct: 969 GAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSRPSFRRTPAWEQQEEPPAPNPPEE 1028
Score = 35.4 bits (80), Expect = 0.45
Identities = 28/80 (35%), Positives = 34/80 (42%), Gaps = 10/80 (12%)
Query: 174 EVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERG 233
+VE R G W G V E S G A + G G++ R E E G
Sbjct: 816 QVEAFESREGGPWGGRVEA--------EESAG-AEDSCGLDPAGSQTARAEGMGAMVEAG 866
Query: 234 GLLERRAALEQRLEGRWQER 253
GLLE+ LE+ G WQER
Sbjct: 867 GLLEKWTLLEEEAVG-WQER 885
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 88.2 bits (217), Expect = 6e-17
Identities = 131/611 (21%), Positives = 255/611 (41%), Gaps = 90/611 (14%)
Query: 517 SSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECP 576
++LQ+E+W +E+ E+++ + + K+ K +E E L+ E + E E+ ++
Sbjct: 230 NTLQEEMWRQEE----ELREQEKKIRKQEEKMWRQE--ERLREQEGKMREQEEKMRRQEK 283
Query: 577 RSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELM 636
R E++ E L+ EKE +E K E ++++ +E + +E +E M
Sbjct: 284 RLREQEKE-LREQEKELREQKKLREQEEQMQEQ---------EEKMWEQEEKMREQEEKM 333
Query: 637 KSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPE--------VGDEEA 688
E L E ++ + +E + +E +E +R E + +EE
Sbjct: 334 WRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEER 393
Query: 689 LRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLE 748
+R E ++ +R E+ +E ++K+ + + E+E Q P + E ++
Sbjct: 394 IR----EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ 449
Query: 749 EQDQETLRTLEKETQQ-----------RRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIAR 797
EQ+++ EK Q R+ + EQ+ EK+ + K DQE
Sbjct: 450 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 509
Query: 798 PLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEI-- 855
E E L+ +E E K + E ++ E K+ E + W EE
Sbjct: 510 W---EQDERLREKEERMREQKKMWQQE---------EKMREEKKTQEQEKKTWDQEEKMR 557
Query: 856 NQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQR 915
+ M EK+++E E + +E + EE+ +E + W E E++ ++ ++
Sbjct: 558 EEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKM--WEQE-----EKMQEQEEK 610
Query: 916 NLEEEENLGKGEYQESLRSLEE---EGQELPQSADVQRW--EDTVEKDQELAQESPPGMA 970
E+EE + + E ++ ++ EE E +E Q + + W E+ + + +E +E M
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQ 670
Query: 971 GVENEDEAELNLREQ-DGFTGKEEVVEQGE---LNATEEVWIPGEGHPESPEPKEQRGLV 1026
G E + +REQ + G+EE + + E E++W G E +E++
Sbjct: 671 GQEEK------MREQEEKMQGQEEKMREQEEKMRGQEEKMW----GQEEKMWGQEEK--- 717
Query: 1027 EGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGS 1086
G E +++ E +++ + + LPE E E + P +
Sbjct: 718 -----MWGQEEMREKE---ERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSV 769
Query: 1087 EPAMGESAAGA 1097
EPA GE+ G+
Sbjct: 770 EPAGGEAGEGS 780
Score = 79.7 bits (195), Expect = 2e-14
Identities = 115/524 (21%), Positives = 227/524 (43%), Gaps = 64/524 (12%)
Query: 506 EKETAIEGKVVSSLQQEIWEEEDLNRKEI-----QDSQVPLEKETLKSLGEEIQESLKTL 560
E+E + K + ++++W +E+ R++ Q+ ++ +++ L+ +E++E K L
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKEL 299
Query: 561 ---------ENQSHETLER--ENQECPRSLEEDL-ETLKSLEKENKELLKDVEVVRPLEK 608
E Q E E+ E +E R EE + + L ++ K++ + + +R E+
Sbjct: 300 REQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 359
Query: 609 EAVGQ-LKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQ---ELVSSLQENL 664
Q + KE+ Q E +E M+ E E E + E +Q+
Sbjct: 360 RMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 665 ESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDE--NKEAFRSLEKENQEPL 722
E++ E++ + R PE ++ + +E +E + E++ ++E EK+
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 479
Query: 723 KTLEEEDQ-----SIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTL 777
K E+EDQ +R E + + EQD+ R EKE + R + Q + +
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE---RLREKEERMREQKKMWQQEEKM 536
Query: 778 RPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENL 837
R +K + K+ DQE E +E K ++EE E++ + QE
Sbjct: 537 REEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE---------EMMREQEEKMQEQE 587
Query: 838 ETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGA 897
E ++ E + +W EE M E+++ E E + +E ++ E+E
Sbjct: 588 EKMR--EQEEKMWEQEE----KMQEQEEKMWEQEEKMWEQEEEDKMQEQEEM-------M 634
Query: 898 WNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEK 957
W E E++ ++ ++ E+EE + E +E +R EE+ Q Q ++ E+ ++
Sbjct: 635 WEQE-----EKMQEQEEKMWEQEEKM--REQEEKMREQEEKMQ--GQEEKMREQEEKMQG 685
Query: 958 DQELAQESPPGMAGVENE--DEAELNLREQDGFTGKEEVVEQGE 999
+E +E M G E + + E +++ G+EE+ E+ E
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEE 729
Score = 69.7 bits (169), Expect = 2e-11
Identities = 143/671 (21%), Positives = 264/671 (39%), Gaps = 87/671 (12%)
Query: 528 DLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSL------EE 581
D +K+I + P ET S G E K +Q E L RE + ++ +
Sbjct: 46 DTKKKKINNGTNP---ETTTSEGCHSPEDEKKASHQHQEALRREIEAQDHTIRILTCQKT 102
Query: 582 DLETLKSLEKENKELLKDVEVVRPLE---------------KEAVGQLKPTGKEDTQTLQ 626
+LET ++ +D + + + A+ + K+ + ++
Sbjct: 103 ELETALYYSQDAARKFEDGNLGESKDLAGRLHHSWHFAGELQRALSAVSTWHKKADRYIE 162
Query: 627 SLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQE-PLRSPEVGD 685
L KE L L N T N+EL E E L E E E L E+
Sbjct: 163 ELTKERDALSLELYRNTIT-------NEELKKKNAELQEKLRLAESEKSEIQLNVKELKR 215
Query: 686 E----EALRPLTKEN--QEPLRSLEDENKEAFRSLEKENQEPLKTLEE--EDQSIVRPLE 737
+ + L P + N QE + E+E +E + + K+ ++ + E E + +R E
Sbjct: 216 KLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQE 275
Query: 738 TENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIAR 797
+ + + L EQ++E LR EKE +++++ L EQ++ EK+ + K +QE
Sbjct: 276 EKMRRQEKRLREQEKE-LREQEKELREQKK-LREQEEQMQEQEEKMWEQEEKMREQE--E 331
Query: 798 PLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQ 857
+ + + + K+ + K + E E + + E + Q +W EE Q
Sbjct: 332 KMWRQEERLWEQEKQMREQEQKMRDQE--ERMWEQDERLREKEERMREQEKMWEQEEKMQ 389
Query: 858 GAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNLE-----NLRSPEEVDK- 911
E+ I+E + + +ET R EE+ Q+ ++ W E R PE+ +K
Sbjct: 390 E-----EERIREREKKMREEEETMREQEEKMQKQEENM--WEQEEKEWQQQRLPEQKEKL 442
Query: 912 -ESQRNLEEEENLGKGEYQESLRSLEEE--------GQELPQSADVQRWEDTV---EKDQ 959
E ++ E+EE + E +E +R EE QE + + Q WE +++Q
Sbjct: 443 WEQEKMQEQEEKI--WEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 500
Query: 960 ELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEE--VWIPGE--GHPE 1015
++ + E E E +REQ +EE + + + +E W E E
Sbjct: 501 KMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEE 560
Query: 1016 SPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGG 1075
+E++ E ++ E +Q+ E + ++ + + + E E + E +
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE-EKMW 619
Query: 1076 DQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQ 1135
+Q + M E M E + + +EE M E+ + +++Q
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQE---------QEEKMWEQEEKMREQEEKMREQEEKMQ 670
Query: 1136 GLEGPRKDLEE 1146
G E ++ EE
Sbjct: 671 GQEEKMREQEE 681
Score = 44.3 bits (103), Expect = 0.001
Identities = 49/233 (21%), Positives = 109/233 (46%), Gaps = 28/233 (12%)
Query: 506 EKETAIEGKVVSSLQQEIWEEEDLNRKE----IQDSQVPLEKETLKSLGEEIQESLKTLE 561
++E E K +++ W++E+ R+E ++ ++ E+E ++ E++QE + +
Sbjct: 532 QEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMR 591
Query: 562 NQSHETLEREN--QECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGK 619
Q + E+E QE + E E K E+E ++ +++ E + ++E + + +
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEE--KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMW 649
Query: 620 EDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLR 679
E + ++ +++ +E + ++G E E +E + +E + +E +E +R
Sbjct: 650 EQEEKMREQEEKMREQEEKMQGQEEKM----REQEEKMQGQEEKM-------REQEEKMR 698
Query: 680 SPEV---GDEEALRPLTKE--NQEPLRSLEDENKEAFRSLEKENQEPLKTLEE 727
E G EE + ++ QE +R E +E R +++ QE L EE
Sbjct: 699 GQEEKMWGQEEKMWGQEEKMWGQEEMR----EKEERIRDQKEKMQERLPEHEE 747
Score = 36.6 bits (83), Expect = 0.20
Identities = 46/221 (20%), Positives = 99/221 (44%), Gaps = 10/221 (4%)
Query: 506 EKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSH 565
EK+ E +++ ++++ E+E+ R+ Q+ ++ ++E ++ E++ E + + Q
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMRE--QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 566 ETLERENQECPRSLEEDLETLKSLEKENKELLKD-VEVVRPLEKEAVGQLKP--TGKEDT 622
E +E +E EE ++ + E +E +++ E +R E++ GQ + +E
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683
Query: 623 QTLQSLQKENQELMKSLEGNL---ETFLFPGTENQELVSSLQENLESLTALEKENQEPLR 679
Q + +E +E M+ E + E ++ E ++E E + +++ QE L
Sbjct: 684 QGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLP 743
Query: 680 SPEVGDEEALRPLTKE--NQEPLRSLEDENKEAFRSLEKEN 718
E E P +K N S+E EA ++N
Sbjct: 744 EHEERCSEPCLPPSKVLCNMSHTGSVEPAGGEAGEGSPQDN 784
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 87.4 bits (215), Expect = 1e-16
Identities = 227/1067 (21%), Positives = 395/1067 (37%), Gaps = 168/1067 (15%)
Query: 7 EESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHAD-DELAALRA 65
E+ Q+ + +R++ LA + + + L EL LR ++ + R H + L+
Sbjct: 246 EKDAQIAMMQQRIDR-LALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKT 304
Query: 66 LVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAW 125
Q R+ + +L+ +L A QQL+ A TEE + K + W
Sbjct: 305 EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHS---------KATQEW 355
Query: 126 LSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEA 185
L Q A+LE+EL A A + ++ E
Sbjct: 356 LEKQ-AQLEKELSA--------------------------------ALQDKKCLEEKNEI 382
Query: 186 WRGAVRGYQERVAHMETSLGQAR-ERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQ 244
+G + +E ++ ++ + Q + E LG +Q L+ L+ E L L+
Sbjct: 383 LQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQ--------LETLKQEAATLAANNTQLQA 434
Query: 245 RLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRT 304
R+E ER + K E+EKQ L S I + L+ K L +
Sbjct: 435 RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494
Query: 305 LLEAENSRLQTPGGGSKTSLSFQDPKLE-LQFPRTPEGRRLGSLLPVLSPTSLPSPLPAT 363
L A+ + L + ++ QD +L L+ + +L L S L
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQAS--QGLRHQ 552
Query: 364 LETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAV--DAEIRAQDAPLSLLQTQGGR 421
+E + + ++ L+ +T Q + A +A +R +DA L L+
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 422 KQAP-EPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAK 480
K A E L+ + +VA A QR++A + E+ + + +A+
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 481 DGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVP 540
V+ L+ ++ E+ +K + +V
Sbjct: 673 -----------------------------------VAELELQLRSEQ---QKATEKERVA 694
Query: 541 LEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDV 600
EK+ L+ + ++ESLK + +LE E + +LEE + L+ E + L++
Sbjct: 695 QEKDQLQEQLQALKESLKVTKG----SLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
Query: 601 EVVR-PLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSS 659
+ R LE+E G+ K Q ++ Q E + L + L E T E
Sbjct: 751 KRERKELEEERAGR-KGLEARLQQLGEAHQAETEVLRREL---AEAMAAQHTAESECEQL 806
Query: 660 LQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQ 719
++E E QE + + E+ + KE E R E KE +E ++
Sbjct: 807 VKEVAAWRERYEDSQQEEAQYGAMFQEQLM--TLKEECEKARQELQEAKEKVAGIESHSE 864
Query: 720 EPL----KTLEEEDQSIVRPLETENHKSLRSLEEQD-----QETLRTLEKETQQRR---R 767
+ L E ++ R L+ K +R+ + D QE + KE + R
Sbjct: 865 LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 768 SLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEF------LKSLKEESVEAVKSL 821
GEQ + R K EP ++ D++ E + ++F L++++ E+ + L
Sbjct: 925 KAGEQQETASRELVK---EPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNEL 981
Query: 822 E---TEILES----LKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESV 874
E ++ES + GQ+ E + + + + + A LE +Q L
Sbjct: 982 ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
Query: 875 EVNQETFR------LLEEENQE----SLRSLGA---WNLENLRSPEEVDKESQRNLEEEE 921
V T + L E+E ++ LR L A LE LR + KE E+E
Sbjct: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
Query: 922 NLGKGEYQESLRSLEEEGQELPQ-SADVQRWEDTVEKDQELAQESPPGMAGVENEDEAEL 980
G G E+ E G +L A+V + E +K QE A +E EAE
Sbjct: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD-------SLERSLEAER 1154
Query: 981 NLREQDGFTGKEEVVE--QGELNATEEVWIPGEGHPESPEPKEQRGL 1025
R + ++ +E QG+L + GH +S QR L
Sbjct: 1155 ASRAE-----RDSALETLQGQLEEKAQEL----GHSQSALASAQREL 1192
Score = 77.4 bits (189), Expect = 1e-13
Identities = 256/1161 (22%), Positives = 434/1161 (37%), Gaps = 240/1161 (20%)
Query: 99 RLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRVAHEEERVGLNAQAACA 158
R R+ E+A NR+ + + +Q+A +++ ++ L + +E++
Sbjct: 227 RSNRDELELELAENRKLLTEK-------DAQIAMMQQRIDRLALLNEKQAAS-------- 271
Query: 159 PRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGA 218
P P+ + E L RL E + + + + M+ + Q E G
Sbjct: 272 ---PLEPKELEELRDKNESLTMRLHETLKQC-QDLKTEKSQMDRKINQLSEENGDLSFKL 327
Query: 219 REGRLELQQLQAERGGLLERRAALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQI 278
RE LQQLQ L E + Q W E+ EK + A Q+K+ L+ +
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQE----WLEKQAQLEK---ELSAALQDKKCLEEK- 379
Query: 279 AQVLEGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRT 338
++L+G+ + LE S+LQ P
Sbjct: 380 NEILQGKL-----------------SQLEEHLSQLQDN-------------------PPQ 403
Query: 339 PEGRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPS 398
+G LG +L + TL+ N LQAR L
Sbjct: 404 EKGEVLGDVLQL-----------ETLKQEAATLAANNTQLQARVEML------------- 439
Query: 399 PAVDAEIRAQDAPLSLLQTQGG---RKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEAS 455
+ E Q+A LL +G KQ L + + +I S L +E Q +A
Sbjct: 440 ---ETERGQQEA--KLLAERGHFEEEKQQLSSLITDLQSSI--SNLSQAKEELEQASQAH 492
Query: 456 TGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKV 515
+ ASL L+ +++++ +D E + GL ++ + ++
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQE-----------------LAGLKQQAKEKQAQL 535
Query: 516 VSSLQQEIWEEEDLNRKEIQ-DSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQE 574
+LQQ+ + L + Q S + +++ LK + E+ QE+ + Q T E +
Sbjct: 536 AQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK-QEATRQDHAQQLATAAEEREA 594
Query: 575 CPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQT-LQSLQKENQ 633
R + L+ L++LEKE L+ ++ + EA ++ QT + Q+E
Sbjct: 595 SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA--------RDSAQTSVTQAQREKA 646
Query: 634 ELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLT 693
EL + +E E T QE + + E L E Q+ V E+
Sbjct: 647 ELSRKVE---ELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEK------ 697
Query: 694 KENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQE 753
+ QE L++L++ K SLE+E + LEE+ + I +E RSL EQ +
Sbjct: 698 DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCI-----SELKAETRSLVEQHKR 752
Query: 754 TLRTLEKE------TQQRRRSLGEQDQMTLRPPEKVDLEPL----------KSLDQEIAR 797
+ LE+E + R + LGE Q + E + + L +E+A
Sbjct: 753 ERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAA 812
Query: 798 PLENEN-------------QEFLKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPE 844
E QE L +LKEE +A + L+ E E K AG E+ L+
Sbjct: 813 WRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ-EAKE--KVAGIESHSELQISR 869
Query: 845 TQAPLWTPEEINQGAMNPL----EKEI--QEPLESVEVNQETFRLLEEE---NQESLRSL 895
Q L E++ L EKE+ Q+ + + QE +E + +R
Sbjct: 870 QQNEL---AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926
Query: 896 G----AWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQR- 950
G + E ++ P LEE++ Q +L+++E E +++ + R
Sbjct: 927 GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 951 --WEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWI 1008
E ++ +E Q+ + A+ +L + + E+ Q LN
Sbjct: 987 ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN------- 1039
Query: 1009 PGEGHPESPEPKEQRGLVEGASVKGG-AEGLQDPEGQSQQVG-APGLQAPQ-----GLPE 1061
EQR VE A+++ A L + EG+ Q++ GL+A Q L +
Sbjct: 1040 ------------EQR--VEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQ 1085
Query: 1062 AIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEP-GP-----GQGVGGLGDPGHLT 1115
++ L E + AS A E+A EP GP V L
Sbjct: 1086 TVKQLKEQLAKKEKEHAS------GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
Query: 1116 REEV--MEPPLE-EESLEAKRVQGLEGPRKDLEE-AGGLGTEFSELPGKSRD------PW 1165
+E+ +E LE E + A+R LE + LEE A LG S L R+
Sbjct: 1140 QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV 1199
Query: 1166 EPPREGREESEAEAPRGAEEA 1186
+ + +E +A+ RG +EA
Sbjct: 1200 QDHSKAEDEWKAQVARGRQEA 1220
Score = 66.2 bits (160), Expect = 2e-10
Identities = 167/800 (20%), Positives = 294/800 (36%), Gaps = 128/800 (16%)
Query: 3 GCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGL-RAQSADTSWRAHADDELA 61
G E + + +LEA A V LE+Q + + L R+ A+ + RA D L
Sbjct: 1106 GAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
Query: 62 ALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKC 121
L+ ++++ +E ++ A + EL + Q A + +VAR R+ E +
Sbjct: 1166 TLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNS 1225
Query: 122 ARAWLSSQVAELERE-LEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELAR 180
+ L +V+ L R+ LE + E +R+ + A + + ++L
Sbjct: 1226 LISSLEEEVSILNRQVLEKEGESKELKRLVM------------------AESEKSQKLEE 1267
Query: 181 RLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRA 240
RL + R A ++L RE + + A + R+ + L+ E ER
Sbjct: 1268 RL-RLLQAETASNSARAAERSSAL---REEVQSLREEAEKQRVASENLRQELTSQAERAE 1323
Query: 241 ALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVA 300
L Q L+ WQE+ E+ A+ L+ E Q+ ++++L + HL L E A
Sbjct: 1324 ELGQELKA-WQEKFFQKEQ---ALSTLQLEHTSTQALVSELLPAK----HLCQQLQAEQA 1375
Query: 301 TYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPL 360
E + + GG + L L Q R LG L+P+ +
Sbjct: 1376 AAEKRHREELEQSKQAAGGLRAEL------LRAQ-------RELGELIPLRQKVAEQERT 1422
Query: 361 PATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGG 420
L ++ + L+ LA + A + Q + L Q +
Sbjct: 1423 AQQLRAEKASYAEQLSMLKKAHGLLAE-------ENRGLGERANLGRQFLEVELDQAREK 1475
Query: 421 RKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPED-----HASLAPPLSPDHS 475
Q +RA+A + A V QR+ ST + E + L
Sbjct: 1476 YVQELAAVRADAETRL-AEV---------QREAQSTARELEVMTAKYEGAKVKVLEERQR 1525
Query: 476 SLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQ 535
E + + + + E Q+ L +K + S Q +++ L + Q
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQVEELSKK-------LADSDQASKVQQQKLKAVQAQ 1578
Query: 536 DSQVPLEKETLKSLGEEIQESLKTLENQS-------------HETLERENQECPRSLEED 582
+ E + L++ E+Q L E + ++ +++NQE L+E
Sbjct: 1579 GGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQE----LQEQ 1634
Query: 583 LETLKSLEKENKELLKDVE-------------------------VVRPLEKE---AVGQL 614
L +L+ L+KENKEL + E VR LE + A QL
Sbjct: 1635 LRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694
Query: 615 KPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQEL--VSSLQENLESLTALEK 672
+ GK T +L+ + L+ ++++ E L S L T++
Sbjct: 1695 RDLGKFQVAT-DALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPG 1753
Query: 673 ENQEPLRS---PEVGDEEAL--RPLTKENQEPLRSLEDENKEAF-RSLEKENQEPLKTLE 726
E P+ P+V E+L P+ +Q PL S D + F S K +T +
Sbjct: 1754 EPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQ 1813
Query: 727 EEDQSIVRPLETENHKSLRS 746
+ ++ + L+ E S S
Sbjct: 1814 IINITMTKKLDVEEPDSANS 1833
Score = 64.7 bits (156), Expect = 7e-10
Identities = 228/1041 (21%), Positives = 382/1041 (36%), Gaps = 153/1041 (14%)
Query: 25 RVKALEEQNELLSAELGGLRAQSADT-SWRAHADDELAA-LRALVDQRWREKHAAEVARD 82
+++AL+E ++ L + ++AD + EL A R+LV+Q RE+ E R
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 83 NLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAELERELEALRV 142
+G+ R QQL A + TE + RR + A+ S+ +L +E+ A R
Sbjct: 763 GR----KGLEARLQQLGEAHQAETEVL---RRELAEAMAAQHTAESECEQLVKEVAAWRE 815
Query: 143 AHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWR--GAVRGYQE-RVAH 199
+E+ + A + E E+ + L EA + + E +++
Sbjct: 816 RYEDSQQEEAQYGAMFQEQLMTLK------EECEKARQELQEAKEKVAGIESHSELQISR 869
Query: 200 METSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRAALEQRL------------- 246
+ L + L RA+Q +E + Q+L + L E+ AA + +
Sbjct: 870 QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQ 929
Query: 247 ------------------EGRWQERLRATE--KFQLAVEALEQEKQGLQSQI----AQVL 282
+ W E + + Q A++A+E+E + + +++ A ++
Sbjct: 930 QETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALM 989
Query: 283 EGRQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLE--LQFPRTPE 340
E + Q + EVA L E R Q K + + + +L+ L R
Sbjct: 990 ESQGQQQEERGQQEREVAR----LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEF 1045
Query: 341 GRRLGSLLPVLSPTSLPSPLPATLETPVPAFLKNQEFLQARTPTL--------------- 385
+L L+ A L A +K E L+ L
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105
Query: 386 -ASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGGRKQAPEPLRA-EARVAIPASVLPG 443
A + + P ++A +RA+ + L Q Q ++QA R+ EA A A
Sbjct: 1106 GAQSEAAGRTEPTGPKLEA-LRAEVSKLEQ-QCQKQQEQADSLERSLEAERASRAERDSA 1163
Query: 444 PEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAKDGESGGSRV----FSICRGEGEG 499
E GQ +E A L S+L + E R S E +
Sbjct: 1164 LETLQGQLEEK------------AQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKA 1211
Query: 500 QIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKT 559
Q+ +E + ++SSL++E+ LNR+ ++ E + LK L E +
Sbjct: 1212 QV-ARGRQEAERKNSLISSLEEEV---SILNRQVLEKEG---ESKELKRLVMAESEKSQK 1264
Query: 560 LENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGK 619
LE E L E + E +L +E + L ++ E R + E + Q +
Sbjct: 1265 LE----ERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQR-VASENLRQELTSQA 1319
Query: 620 EDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSL-------QENLESLTALEK 672
E + L K QE E L T T Q LVS L Q+ A EK
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 673 ENQEPLRSPEVGDEEALRPLTKENQE-----PLRSLEDENKEAFRSLEKENQEPLKTLEE 727
++E L + L + +E PLR E + + L E K
Sbjct: 1380 RHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAE-----KASYA 1434
Query: 728 EDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEP 787
E S+++ + R L E+ + LE E Q R Q+ +R + L
Sbjct: 1435 EQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKY-VQELAAVRADAETRLAE 1493
Query: 788 LKSLDQEIARPLE--------------NENQEFLKSLKE-----ESVEAVKSLETEILES 828
++ Q AR LE E Q F + ++ E +E + +T+ +E
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEE 1553
Query: 829 L--KSAGQENLETLKSPETQAPLWTPEEINQGA--MNPLEKEIQEPLESVEVNQETFRLL 884
L K A + ++ + +A E Q A + E+Q L E E ++L
Sbjct: 1554 LSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQ 1613
Query: 885 EEENQESLRSLGAWNLE---NLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQE 941
E+ + + N E LRS E++ KE++ E E LG Q L++ E E
Sbjct: 1614 MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTC 1673
Query: 942 LPQSADVQRWEDTV-EKDQEL 961
+A V+ E V DQ+L
Sbjct: 1674 RHLTAQVRSLEAQVAHADQQL 1694
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 85.9 bits (211), Expect = 3e-16
Identities = 121/538 (22%), Positives = 241/538 (44%), Gaps = 92/538 (17%)
Query: 506 EKETAIEGKVVSSLQQEIWEEEDLNRKEIQDS--------QVPLEKETLKSLGEEIQESL 557
EK+ K +SL+ ++ + ++L ++E + Q+ EK +L+ EE +E+
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359
Query: 558 KTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVV-RPLEKEAVG--QL 614
K LE Q L+ + + + +++DL T++SLE+ K+LLKD E + + LE++A+ +L
Sbjct: 1360 KNLEKQVL-ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 615 KPTGKEDTQTLQSLQKE---NQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALE 671
+ T Q L L + +++ +LE + F E + + + E + A
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 672 KENQEPLRSPEVGDEEAL---RPLTKENQEPLRSLED-------------ENKEAFRSLE 715
+E + S EEAL ++N++ +ED E +++ R+LE
Sbjct: 1479 REKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 716 KENQEPLKTLEEEDQSI-------------VRPLETENHKSLRSLEEQDQETLRTLEKET 762
++ +E LEE + + ++ ++ + + L++ +EQ++E R L K+
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 763 QQRRRSL-GEQDQMTLRPPEKVDLE-PLKSLDQEI-------------ARPLENENQEFL 807
++ L E+ Q L K +E LK L+ +I R L+ + +++
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 808 KSLKE-------------ESVEAVKSLETEILE----------SLKSAGQEN----LETL 840
+ L+E ES + +KSLE EIL+ + + A QE E
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT 1718
Query: 841 KSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFR----LLEEENQE-SLRSL 895
S ++ L + + + LE+E++E ++E+ + FR ++ N E +
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERS 1778
Query: 896 GAWNLENLRSP-EEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWE 952
A +N R E +KE + L+E E K +++ ++ +LE + +L + + + E
Sbjct: 1779 AAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Score = 79.3 bits (194), Expect = 3e-14
Identities = 129/579 (22%), Positives = 265/579 (45%), Gaps = 77/579 (13%)
Query: 526 EEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLET 585
EE L+ +E ++ LEK T ++ ++++E + LE+Q+ + ++ + + +E+ +
Sbjct: 956 EEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK-----KLMEDRIAE 1010
Query: 586 LKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLET 645
S E +E K++ +R ++ + L+ K++ +T Q L+K + L+G
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK----RKLDGET-- 1064
Query: 646 FLFPGTENQELVSSLQENLESL-TALEKENQEPLRSPEVGDEEALR-----PLTKENQEP 699
T+ Q+ ++ LQ ++ L L K+ +E + GD+E L + +E Q
Sbjct: 1065 -----TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 700 LRSLEDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLE-----TENHKSLRSLEEQD-QE 753
+ L+ E+ E+ ++ + ++ + L EE +++ LE T + LR+ EQ+ E
Sbjct: 1120 IAELQ-EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 754 TLRTLEKETQQRRRSLGEQDQMTLRPPEKV--DLEPLKSLDQEIAR---PLENENQEF-- 806
+ LE+ET+ + + Q E++ LE K + + LE +N+E
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELAC 1238
Query: 807 ----LKSLKEESVEAVKSLETEILESLKSAGQENLETLKSPETQAPLWTPEEINQGAMNP 862
L+ +K ES K L+ ++ E + + ++ E + L + +
Sbjct: 1239 EVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298
Query: 863 LEK---EIQEPLESVEVN-QETFRLLEEENQESLR-SLGAWNLE----NLRSPEEVDKES 913
EK + + S+E Q+T LL+EE ++ L S LE +L+ +E ++E+
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 914 QRNLEEEENLGKGEYQE----------SLRSLEEEGQELPQSADV--QRWE------DTV 955
++NLE++ + + + ++ SLEE ++L + A+ QR E D +
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 956 EKDQ-ELAQESPPGMAGVENEDEAELNL-REQDGFTGKEEVVEQGELNA--TEEVWIPGE 1011
EK + L QE ++++ + NL ++Q F + + E+ ++A EE
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF--DQLLAEEKSISARYAEE---RDR 1473
Query: 1012 GHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQQVGA 1050
E+ E KE + L +++ E ++ E Q++Q+ A
Sbjct: 1474 AEAEARE-KETKALSLARALEEALEAKEEFERQNKQLRA 1511
Score = 73.2 bits (178), Expect = 2e-12
Identities = 118/601 (19%), Positives = 264/601 (43%), Gaps = 83/601 (13%)
Query: 498 EGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVPLEKETLKSLGEEIQESL 557
+G+ L ++ ++ ++ Q +EE+L + L K + E+Q +
Sbjct: 1061 DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQI 1120
Query: 558 KTLEN--QSHETLERENQECPRSLEEDLETLKSLEKENKELLKDVEVVRPLEKEAVGQLK 615
L+ +S + + ++ R L E+LE LK+ ++ + + +R ++ V +LK
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK 1180
Query: 616 PTGKEDTQT----LQSLQKENQELMKSLEGNLETFLFPGTENQELVSSLQENLESLTALE 671
+E+T+ +Q +++ + ++ L LE + + ++L++N + L
Sbjct: 1181 KALEEETKNHEAQIQDMRQRHATALEELSEQLE-------QAKRFKANLEKNKQGLETDN 1233
Query: 672 KE---NQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQEPLKTLEEE 728
KE + L+ + E + L + QE + + ++ L E E L+ E
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR-----LRVELAEKASKLQNE 1288
Query: 729 DQSIVRPLETENHKSLR------SLEEQDQETLRTLEKETQQ------RRRSLGEQDQMT 776
++ LE K ++ SLE Q Q+T L++ET+Q R R L E+++ +
Sbjct: 1289 LDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQL-EEEKNS 1347
Query: 777 LRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEE--SVEAVKSLETEILESLKSAGQ 834
L+ ++ + E K+L++++ L+++ + K + ++ ++E+++ + ++L+ ++ Q
Sbjct: 1348 LQEQQEEEEEARKNLEKQVL-ALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 835 ---------ENLETLKSPETQA--PLWTPEEINQGAMNPLEKE--------IQEPLESVE 875
+ LE K+ Q L + + + LEK+ +E S
Sbjct: 1407 RLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISAR 1466
Query: 876 VNQETFRLLEEENQESLRSLGAWNL--ENLRSPEEVDKESQR-------NLEEEENLGKG 926
+E R E ++ ++L E L + EE ++++++ + ++++GK
Sbjct: 1467 YAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKN 1526
Query: 927 --EYQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLRE 984
E ++S R+LE++ +E+ ++ ED ++ ++ M ++ + E +L R+
Sbjct: 1527 VHELEKSKRALEQQVEEM--RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRD 1584
Query: 985 QDGFTGKEEVVEQ-GELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEG 1043
+ K +++Q EL A E + ++QR L AS K L+D E
Sbjct: 1585 EQNEEKKRLLIKQVRELEA------------ELEDERKQRALAV-ASKKKMEIDLKDLEA 1631
Query: 1044 Q 1044
Q
Sbjct: 1632 Q 1632
Score = 48.1 bits (113), Expect = 7e-05
Identities = 169/874 (19%), Positives = 341/874 (39%), Gaps = 102/874 (11%)
Query: 11 QMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDELAALRALVDQR 70
Q+ EL E+ A E+Q LS EL L+ + DT A EL R
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR------ 1172
Query: 71 WREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQV 130
E+ AE+ + L EE + + Q +R EE++ +E K +A L
Sbjct: 1173 --EQEVAELKKA-LEEETKNHEAQIQDMRQRHATALEELSEQ---LEQAKRFKANLEKNK 1226
Query: 131 AELERE----------LEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELAR 180
LE + L+ ++ E +R L+AQ V+EL
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ--------------------VQELHA 1266
Query: 181 RLGEAWRGAVRGYQERVAHMETSLGQARERLGRA----VQGAREGRLELQQLQAERGGLL 236
++ E R V E+ + ++ L L A ++ A++ QLQ + L
Sbjct: 1267 KVSEGDRLRVE-LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 237 ERRAALEQRLEGRWQERLRATEKFQLAV-EALEQEKQGLQSQIAQVLEGRQQLAHLKMSL 295
E E R + R+R E+ + ++ E E+E++ ++ QVL + QLA K +
Sbjct: 1326 E-----ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 296 SLEVATYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTS 355
++ T +L EA+ L+ S ++ L + R L +
Sbjct: 1381 DDDLGTIESLEEAKKKLLK---DAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 356 LPSPLPATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSL- 414
+ + LE F + L A ++++ +A + A + E +A +L
Sbjct: 1438 HQRQVASNLEKKQKKF----DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493
Query: 415 --LQTQGGRKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSP 472
L+ + ++ + LRA+ + + G ++ + + Q E+ + L
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 473 DHSSLEAKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQ-EIWEEEDLNR 531
+ + E D + + + E + E+ + ++ +++ E E++ +
Sbjct: 1554 ELQATE--DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 532 KEIQDSQVPLEKETLKSLGEEIQESLKTLEN--QSHETLERENQECPRSLEEDLETLKSL 589
+ + + + LK L +I+ + K + + L+ + ++ R LEE + +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 590 EKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNL---ETF 646
++KE K ++ LE E + QL+ + + ++E EL + +
Sbjct: 1672 FAQSKESEKK---LKSLEAEIL-QLQEELASSERARRHAEQERDELADEITNSASGKSAL 1727
Query: 647 LFPGTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDE 706
L + ++ L+E LE E+ N E L + L E RS +
Sbjct: 1728 LDEKRRLEARIAQLEEELEE----EQSNMELLNDRFRKTTLQVDTLNAELAAE-RSAAQK 1782
Query: 707 NKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRR 766
+ A + LE++N+E L+E + ++ +++ ++ +LE + + LE++ +Q
Sbjct: 1783 SDNARQQLERQNKELKAKLQELEGAV----KSKFKATISALEAK----IGQLEEQLEQEA 1834
Query: 767 RSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQ--EFLKSLKEESVEAVKSLETE 824
+ +++ R +K+ +EI +E+E + + K E++ +K L+ +
Sbjct: 1835 KERAAANKLVRRTEKKL---------KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQ 1885
Query: 825 ILESLKSAGQENLETLKSPETQAPLWTPEEINQG 858
+ E+ + A + N K Q L E N+G
Sbjct: 1886 LEEAEEEATRANASRRK---LQRELDDATEANEG 1916
Score = 40.8 bits (94), Expect = 0.011
Identities = 61/325 (18%), Positives = 128/325 (39%), Gaps = 16/325 (4%)
Query: 14 ELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHA-DDELAALRALVDQRWR 72
E+ ++L A++K + + E A + AQS ++ + + + E+ L+ + R
Sbjct: 1642 EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 73 EKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEKCARAWLSSQVAE 132
+ AE RD LA+E+ A L + R +A+ +E E+ L+ + +
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761
Query: 133 LERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELARRLGEAWRGAVRG 192
+++ L ER AQ + R + A +++EL + ++ +
Sbjct: 1762 TTLQVDTLNAELAAERSA--AQKSDNARQQLERQNKELKA-KLQELEGAVKSKFKATISA 1818
Query: 193 YQERVAHMETSLGQARERLGRAVQGAREGRLELQ----QLQAERGGLLERRAALEQRLEG 248
+ ++ +E L Q + A + R +L+ Q++ ER + + +E +
Sbjct: 1819 LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME-KANA 1877
Query: 249 RWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVATYRTLLEA 308
R ++ R E+ + ++ LQ ++ E + LS EV+T + L
Sbjct: 1878 RMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANE-------GLSREVSTLKNRLRR 1930
Query: 309 ENSRLQTPGGGSKTSLSFQDPKLEL 333
+ + L + LEL
Sbjct: 1931 GGPISFSSSRSGRRQLHLEGASLEL 1955
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.127 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 75,647,183
Number of Sequences: 37866
Number of extensions: 4702620
Number of successful extensions: 43534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 324
Number of HSP's successfully gapped in prelim test: 2170
Number of HSP's that attempted gapping in prelim test: 20877
Number of HSP's gapped (non-prelim): 15424
length of query: 1621
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1505
effective length of database: 13,855,062
effective search space: 20851868310
effective search space used: 20851868310
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.