Search of human proteins with 34878693

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34878693 NLR family, pyrin domain containing 3 isoform a
[Homo sapiens]
         (1036 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho...  2106   0.0  
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom...  2106   0.0  
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho...  1923   0.0  
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...  1816   0.0  
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...  1622   0.0  
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...   916   0.0  
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]     624   e-178
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]     540   e-153
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]      524   e-148
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]       492   e-139
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...   485   e-137
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo...   463   e-130
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom...   463   e-130
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom...   463   e-130
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]   463   e-130
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom...   461   e-129
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom...   461   e-129
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof...   446   e-125
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof...   438   e-122
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]      435   e-121
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso...   433   e-121
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]      405   e-113
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]    382   e-106
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]     356   6e-98
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]          225   1e-58
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]          225   1e-58
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]          225   1e-58
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]          225   1e-58
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]          225   1e-58
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]          225   1e-58

>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score = 2106 bits (5456), Expect = 0.0
 Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)

Query: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
            MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60

Query: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
            FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120

Query: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
            LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180

Query: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
            QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240

Query: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
            LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300

Query: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
            MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360

Query: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
            LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420

Query: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
            GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480

Query: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
            KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540

Query: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
            EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600

Query: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
            SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660

Query: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
            MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
Sbjct: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720

Query: 721  VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
            VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
Sbjct: 721  VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780

Query: 781  GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840
            GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
Sbjct: 781  GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840

Query: 841  SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900
            SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
Sbjct: 841  SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900

Query: 901  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960
            CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
Sbjct: 901  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960

Query: 961  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020
            LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
Sbjct: 961  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020

Query: 1021 LQEEKPELTVVFEPSW 1036
            LQEEKPELTVVFEPSW
Sbjct: 1021 LQEEKPELTVVFEPSW 1036


>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score = 2106 bits (5456), Expect = 0.0
 Identities = 1036/1036 (100%), Positives = 1036/1036 (100%)

Query: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
            MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60

Query: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
            FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120

Query: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
            LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180

Query: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
            QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240

Query: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
            LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300

Query: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
            MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360

Query: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
            LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420

Query: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
            GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480

Query: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
            KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540

Query: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
            EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600

Query: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
            SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660

Query: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
            MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
Sbjct: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720

Query: 721  VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
            VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC
Sbjct: 721  VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780

Query: 781  GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840
            GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
Sbjct: 781  GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840

Query: 841  SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900
            SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
Sbjct: 841  SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900

Query: 901  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960
            CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
Sbjct: 901  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960

Query: 961  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020
            LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
Sbjct: 961  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020

Query: 1021 LQEEKPELTVVFEPSW 1036
            LQEEKPELTVVFEPSW
Sbjct: 1021 LQEEKPELTVVFEPSW 1036


>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
            sapiens]
          Length = 979

 Score = 1923 bits (4981), Expect = 0.0
 Identities = 967/1036 (93%), Positives = 969/1036 (93%), Gaps = 57/1036 (5%)

Query: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
            MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60

Query: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
            FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120

Query: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
            LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180

Query: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
            QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240

Query: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
            LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300

Query: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
            MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360

Query: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
            LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420

Query: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
            GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480

Query: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
            KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540

Query: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
            EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600

Query: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
            SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660

Query: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
            MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGR                     
Sbjct: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGR--------------------- 699

Query: 721  VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
               HL    C     VL +S                          H  C+     LGRC
Sbjct: 700  ---HLDMVQC-----VLPSSS-------------------------HAACSHG---LGRC 723

Query: 781  GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840
            GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT
Sbjct: 724  GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 783

Query: 841  SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900
            SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC
Sbjct: 784  SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 843

Query: 901  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960
            CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
Sbjct: 844  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 903

Query: 961  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020
            LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
Sbjct: 904  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 963

Query: 1021 LQEEKPELTVVFEPSW 1036
            LQEEKPELTVVFEPSW
Sbjct: 964  LQEEKPELTVVFEPSW 979


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
            sapiens]
          Length = 979

 Score = 1816 bits (4705), Expect = 0.0
 Identities = 913/1036 (88%), Positives = 937/1036 (90%), Gaps = 57/1036 (5%)

Query: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
            MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1    MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60

Query: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
            FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61   FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120

Query: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
            LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121  LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180

Query: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
            QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181  QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240

Query: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
            LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241  LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300

Query: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
            MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301  MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360

Query: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
            LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361  LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420

Query: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
            GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421  GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480

Query: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
            KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540

Query: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
            EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600

Query: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
            SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660

Query: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
            MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSS     SH  
Sbjct: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSS-----SHAA 715

Query: 721  VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
             +  L +S                                                    
Sbjct: 716  CSHGLVNSH--------------------------------------------------- 724

Query: 781  GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840
             L+   C  +  VLS++Q L ELDLSDN+LGD G+R+LC  L+H  CN+++LWL  C L+
Sbjct: 725  -LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLS 783

Query: 841  SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900
              CC D++ VLS++  L  L + +NALGD G+ +LC   K+  CNL+KL LVNSGLTSVC
Sbjct: 784  HECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVC 843

Query: 901  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 960
            CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD
Sbjct: 844  CSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWD 903

Query: 961  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 1020
            LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET
Sbjct: 904  LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALET 963

Query: 1021 LQEEKPELTVVFEPSW 1036
            LQEEKPELTVVFEPSW
Sbjct: 964  LQEEKPELTVVFEPSW 979


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
           sapiens]
          Length = 922

 Score = 1622 bits (4201), Expect = 0.0
 Identities = 811/918 (88%), Positives = 840/918 (91%)

Query: 1   MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60
           MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID
Sbjct: 1   MKMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMID 60

Query: 61  FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120
           FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL
Sbjct: 61  FNGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGL 120

Query: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180
           LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ
Sbjct: 121 LEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQ 180

Query: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240
           QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM
Sbjct: 181 QEREQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMM 240

Query: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300
           LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL
Sbjct: 241 LDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFL 300

Query: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360
           MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH
Sbjct: 301 MDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQH 360

Query: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420
           LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT
Sbjct: 361 LLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCT 420

Query: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480
           GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ
Sbjct: 421 GLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQ 480

Query: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
           KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK
Sbjct: 481 KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540

Query: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
           EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI
Sbjct: 541 EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600

Query: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
           SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR
Sbjct: 601 SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660

Query: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720
           MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL
Sbjct: 661 MDHMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGL 720

Query: 721 VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
               L+   C  +  VLS++Q L ELDLSDN+LGD G+R+LC  L+H  CN+++LWL   
Sbjct: 721 GRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNS 780

Query: 781 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLT 840
           GL+  CC  +S VLS+NQ L  L L  N LGD GI+LLC GL H  C L+ L L +C LT
Sbjct: 781 GLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLT 840

Query: 841 SACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVC 900
           S CC DL+++L++S SL +L +G N LGD GV + CE  K   C LQ LGL         
Sbjct: 841 SHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYET 900

Query: 901 CSALSSVLSTNQNLTHLY 918
            SAL ++      LT ++
Sbjct: 901 KSALETLQEEKPELTVVF 918



 Score =  347 bits (891), Expect = 3e-95
 Identities = 170/200 (85%), Positives = 181/200 (90%)

Query: 837  CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 896
            C L+  CC D++ VLS++  L  L + +NALGD G+ +LC   K+  CNL+KL LVNSGL
Sbjct: 723  CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782

Query: 897  TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 956
            TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH
Sbjct: 783  TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842

Query: 957  CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 1016
            CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS
Sbjct: 843  CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 902

Query: 1017 ALETLQEEKPELTVVFEPSW 1036
            ALETLQEEKPELTVVFEPSW
Sbjct: 903  ALETLQEEKPELTVVFEPSW 922



 Score =  100 bits (249), Expect = 7e-21
 Identities = 57/116 (49%), Positives = 70/116 (60%)

Query: 890  GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 949
            GL   GL+  CC  +S VLS+NQ L  L L  N LGD GI+LLC GL H  C L+ L L 
Sbjct: 719  GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLV 778

Query: 950  NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 1005
            N  LTS CC  LS++L+++Q+L  L L  N LGD G+ + CE L    C LQ L L
Sbjct: 779  NSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 834



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 30/85 (35%), Positives = 45/85 (52%)

Query: 948  LDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
            L  C L+  CC+D+S +L+S+Q L +L L +N LGD G+ + C  LK   C L+ L L  
Sbjct: 720  LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779

Query: 1008 MYFNYETKSALETLQEEKPELTVVF 1032
                    SAL ++      LT ++
Sbjct: 780  SGLTSVCCSALSSVLSTNQNLTHLY 804


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
            sapiens]
          Length = 1061

 Score =  916 bits (2368), Expect = 0.0
 Identities = 504/1072 (47%), Positives = 682/1072 (63%), Gaps = 72/1072 (6%)

Query: 8    CKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKA 67
            C+L+ YLE+LE V+LKKFK++L     + G   +P G  EKA  +++A L+I   G E+A
Sbjct: 11   CRLSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEA 69

Query: 68   WAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
            W +A+  F  INR+DL+E+ +R+      D  R + P       S+  +   LLE    +
Sbjct: 70   WRLALSTFERINRKDLWERGQRE------DLVRDTPPG---GPSSLGNQSTCLLE----V 116

Query: 128  SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
            S+   +KD ++ YR YVR +F+ +EDRNARLGE V+L+ RYTRL L+KEH +  + +Q+L
Sbjct: 117  SLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQL 176

Query: 188  LAIGK--TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWAS 245
            L  G+   +T     SPIK+E LF+PD+E  EP  TVV QGAAGIGK++LA K+MLDWA 
Sbjct: 177  LDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWAD 236

Query: 246  GTLYQDRFDYLFYIHCREVSL-VTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGF 304
            G L+Q RFDYLFYI+CRE++   T+ S+ DLI SC P+P+ P+ +++R P R+LF++DGF
Sbjct: 237  GKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGF 296

Query: 305  DELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDH 364
            DEL+ +F +  GP C  W++    ++LL+SLIRKKLLPE SLLITTRP ALEKL  LL+H
Sbjct: 297  DELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEH 356

Query: 365  PRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQ 424
            PRHVEILGFSEA+RKEYF+KYF +  QA   F+ +++NE LFTMCF+PLVCW+VCT L+Q
Sbjct: 357  PRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQ 416

Query: 425  QMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILF 484
            Q+E G  L QTS+TTTAVY+ +L SL+QP+ G+       +  GLCSLAADG+WNQKILF
Sbjct: 417  QLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILF 476

Query: 485  EESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRT 544
            EE DLR HGL   DVSAFL MN+FQK+++CE++YSFIH++FQEFFAAMYY+L+E + G  
Sbjct: 477  EEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG 536

Query: 545  NVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQI 604
                     P +DVT LL  Y   E+ +L    RFLFGL+N+E  S+LEK L  K+S  I
Sbjct: 537  ---------PDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHI 587

Query: 605  RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEI-NLSTRMDH 663
            +++LL+WI+ KA++    +Q   LE F CLYE+QEE+F+Q+A+ +F  I + N++++M+H
Sbjct: 588  KMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEH 647

Query: 664  MVSSFCIENCHRVESLSL-GFLHNMPKEEEEEEKEGRHLDMVQ----------------- 705
            MVSSFC++ C   + L L G  ++   E+      G H  +VQ                 
Sbjct: 648  MVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAA 707

Query: 706  --CVLPS------SSHAACSHG-------------------LVNSHLTSSFCRGLFSVLS 738
              C  P+        +A  S G                   L    ++SS C  L + L 
Sbjct: 708  ALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALI 767

Query: 739  TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
             +++LT +DLS N +G PGM +LCE L+HP C ++ + L +C L    C +++ VL +N 
Sbjct: 768  ANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNP 827

Query: 799  KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
             LVELDL+ NAL D G+RLLC GL+H +C L+ LWL  C LT+A C +LAS LS + SL 
Sbjct: 828  HLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLR 887

Query: 859  RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLY 918
             L +  N LGD GV +LCE  ++P C LQ L L    L S  C  LS VL  N NL  L 
Sbjct: 888  ELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELD 947

Query: 919  LRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGN 978
            L  N LGD G+ LL EGL HP C+LQ L LD+C LT+  C +L   L  +Q+L  L L N
Sbjct: 948  LSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTN 1007

Query: 979  NDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
            N LGD GV + C+ L    C L+ L L  M  N  T S L  L+  KP L +
Sbjct: 1008 NALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score =  624 bits (1609), Expect = e-178
 Identities = 385/1039 (37%), Positives = 572/1039 (55%), Gaps = 103/1039 (9%)

Query: 10   LARYLEDLEDVDLKKFKMHL-EDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
            L  YLE+L   +L  FK+ L E   P+ G  P    + +KA   DLA LM  +   EKAW
Sbjct: 15   LLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPGEKAW 72

Query: 69   AMAVWIFAAINRRDLYEKAKRDEPKW-----GSDNARVSNPTVICQEDSIEEEWMGLLEY 123
            ++++ IF  +N +DL E+AK +E  W     G D+A+        QED  +E  +G    
Sbjct: 73   SVSLKIFGKMNLKDLCERAK-EEINWSAQTIGPDDAKAGE----TQED--QEAVLG---- 121

Query: 124  LSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQER 183
                           +YR  ++ +F    D+ +  G+                H    E+
Sbjct: 122  ------------DGTEYRNRIKEKFCITWDKKSLAGKPEDF------------HHGIAEK 157

Query: 184  EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDW 243
            +++LL                 E LFD D +       VV QGAAG+GKT L RK MLDW
Sbjct: 158  DRKLL-----------------EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDW 200

Query: 244  ASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDG 303
            A G+LYQ RF Y+FY++ RE++ + +RS   LI    P    PI +I+ +PS +LF++D 
Sbjct: 201  AEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDS 260

Query: 304  FDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLD 363
            FDEL  AF+E    LC DW +      L+SSL+RK +LPEASLL+TTR    ++L+ LL 
Sbjct: 261  FDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLK 320

Query: 364  HPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLK 423
            +  +VE+LG SE  R+EY +++F D+  A   FS ++ NE+LF+MC +PLVCW  CT LK
Sbjct: 321  NHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK 380

Query: 424  QQMESGKSLAQTSKTTTAVYVFFLSSLLQP-RGGSQEHGLCAHLWGLCSLAADGIWNQKI 482
            QQME G  +  T +TTTA++  ++SSL  P  GGS      A L  LC +AA GIW    
Sbjct: 381  QQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTY 440

Query: 483  LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG 542
            +F   +LR  GL ++DVS+F+  N+ QK+ + E  Y F H+  QEFFAAM+Y+L+   E 
Sbjct: 441  VFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEA 500

Query: 543  RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
                 G+    P  D+  LL++   ++  +L  +  FLFGL+N++R   LE+  +CK+S 
Sbjct: 501  -----GNPSCQPFEDLKSLLQS-TSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554

Query: 603  QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
            +I+ +LL+ +EV   +     Q   LELF+CLYE Q++ F+ +AM  FPK+ IN+  ++ 
Sbjct: 555  KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614

Query: 663  HMVSSFCIENCHRVESLSLG---------FLHNMPKEEEEEEK----------------E 697
             +VSSFC+++C  + ++ L             ++P    + ++                 
Sbjct: 615  LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674

Query: 698  GRHLDMVQCVLPSSSHAACSHGLVNSH-----LTSSF------CRGLFSVLSTSQSLTEL 746
             R LD+    L  S+     H L + +     L   F      C+ + + L  +++L  L
Sbjct: 675  LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734

Query: 747  DLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLS 806
            DL  + +GD G++ LCE L+HP C ++ L L  C L+  CC +IS  L  +Q L+ L+LS
Sbjct: 735  DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794

Query: 807  DNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENA 866
             N L D G++LLC  L+H  C L++L L SC LT A C+ L+  L ++  LT L + +N 
Sbjct: 795  TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854

Query: 867  LGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGD 926
            LGD GV ++ +  ++ QC L+ L L     TS+    LS+ L  N++LTHL L  N L D
Sbjct: 855  LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914

Query: 927  KGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGV 986
             G+KLLC+   HP C LQ LEL  C LT+ CC DL++++ ++ +LR L LGNNDL D GV
Sbjct: 915  NGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGV 974

Query: 987  MMFCEVLKQQSCLLQNLGL 1005
             + C+ L+  +C +Q LGL
Sbjct: 975  KILCDALRYPNCNIQRLGL 993



 Score =  240 bits (613), Expect = 4e-63
 Identities = 143/366 (39%), Positives = 205/366 (56%), Gaps = 21/366 (5%)

Query: 677  ESLSLGFLHNMPKEEEEEEKEGRHLDM---------VQCVLPSSSHAAC---SHGLVNSH 724
            + +S   +HN         K   HLD+         V+ +  +  H  C   +  L + +
Sbjct: 719  QDISTSLIHN---------KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCN 769

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            LT   C  + + L  SQSL  L+LS N+L D G+++LCE L+HP C + RL L  CGL+ 
Sbjct: 770  LTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829

Query: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
              C  +SL L SN++L  L L+DN LGD G++L+   L+H  C LK L L  C  TS   
Sbjct: 830  AGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSS 889

Query: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
            + L++ L  + SLT L +G N L D+GV +LC+  ++P CNLQ L L+   LT+ CC  L
Sbjct: 890  EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949

Query: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
            +SV+  N NL  L L  N L D G+K+LC+ L +P+C +Q L L+ C LTS CC DLS+ 
Sbjct: 950  ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009

Query: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEE 1024
            L  ++ L K++L  N LG  G++   +VLK   C LQ LGL +  F+ E +  LE +   
Sbjct: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069

Query: 1025 KPELTV 1030
             P L +
Sbjct: 1070 NPHLII 1075



 Score =  147 bits (370), Expect = 7e-35
 Identities = 91/244 (37%), Positives = 130/244 (53%), Gaps = 1/244 (0%)

Query: 786  CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 845
            C  D+  VL +N+ L ELDL  + L    + +L   L+H  C L+KL L        C Q
Sbjct: 661  CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGC-Q 719

Query: 846  DLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALS 905
            D+++ L  + +L  L +  + +GD+GV  LCE  K+P+C LQ L L +  LT  CC  +S
Sbjct: 720  DISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNIS 779

Query: 906  SVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLL 965
            + L  +Q+L  L L  N L D G++LLCE L HP C L+ L L++C LT   C  LS  L
Sbjct: 780  NALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839

Query: 966  TSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEK 1025
             S++ L  L L +N LGD GV +  + L+   C L++L L   +F   +   L T     
Sbjct: 840  ISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHN 899

Query: 1026 PELT 1029
              LT
Sbjct: 900  KSLT 903


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score =  540 bits (1391), Expect = e-153
 Identities = 350/1053 (33%), Positives = 537/1053 (50%), Gaps = 119/1053 (11%)

Query: 13   YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
            YLE+L+  + +KFK HL+    Q     +P  + +KA   +LA L+I    E++AW + +
Sbjct: 14   YLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITL 73

Query: 73   WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
             IF  ++R+DL  K  R+                                          
Sbjct: 74   RIFQKMDRKDLCMKVMRE------------------------------------------ 91

Query: 133  KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
            +  Y K Y+ + + +F       +RL  S S+    T + L  E   +QE          
Sbjct: 92   RTGYTKTYQAHAKQKF-------SRLWSSKSV----TEIHLYFEEEVKQEE--------- 131

Query: 193  TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
               C+       ++ LF P +   +P  TV+ QG  GIGKT L  K+M+ W+   +++DR
Sbjct: 132  ---CDH------LDRLFAPKEAGKQP-RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDR 181

Query: 253  FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
            F Y FY  CRE+  +   SL DLI    PDP  PI +IV +P R+LF++D F+ELQG  +
Sbjct: 182  FLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLN 241

Query: 313  EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
            E    LC D  +     +LLSSL+RKK+LPEASLLI  +PV  ++L+  +      +  G
Sbjct: 242  EPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRG 301

Query: 373  FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
            F+E+ R  YF  +F D  +A  AF+L++E+E LF++C IPL+CWI+CT LKQ+M+ GK L
Sbjct: 302  FNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDL 361

Query: 433  AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH-LWGLCSLAADGIWNQKILFEESDLRN 491
            A T ++TT+VY  F+ +L  P G         H L  LCSLAA+G+W     F E DLR 
Sbjct: 362  ALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRR 421

Query: 492  HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
            +G+  AD+ A L   +  K  + E  Y F+H+  QEF AA++YLL+           S L
Sbjct: 422  NGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLK-----------SHL 470

Query: 552  KLPSRDV----TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
              P   V     +L+ N+ K  + + IF+  FL GL+N++    L+     ++SQ+I+ +
Sbjct: 471  DHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQ 530

Query: 608  LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
            + + ++   +    Q Q   L +FYCL+EMQ+  FV++A++   +   ++   +D +VS+
Sbjct: 531  IHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSA 590

Query: 668  FCIENCHRVESLSLGFLHNMPKEEEEEEKEG-------------------RHLDMVQCVL 708
            +C++ C  +  L     +   KE+E                         R L +    L
Sbjct: 591  YCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTL 650

Query: 709  PSSSHAACSHGL-----------VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPG 757
              S+     + L           +N+   S     LF VL     L  L  +   L    
Sbjct: 651  SESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDD 710

Query: 758  MRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 817
            +R LC+ L +P  N++ L L  C LS   C  ++ +L++N+KL  L++S N L D G+ L
Sbjct: 711  IRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPL 769

Query: 818  LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 877
            LC  L      L  L L  C L+  CC+ ++ +L  + S+  L +  N L D G+  LCE
Sbjct: 770  LCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCE 829

Query: 878  KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 937
              K+P C L  L LV   +T+  C  L+S L +NQNL  L +  N +GD G++LLC  L 
Sbjct: 830  ALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALT 889

Query: 938  HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 997
            H DC+L++L L+ C LTS CC DL+++LT S++L++L+L  N L   GV++ CE L+   
Sbjct: 890  HTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPE 949

Query: 998  CLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
            C LQ LGL +  F+ ET++ L   +E  P LT+
Sbjct: 950  CALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982


>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
          Length = 991

 Score =  524 bits (1350), Expect = e-148
 Identities = 340/1055 (32%), Positives = 544/1055 (51%), Gaps = 123/1055 (11%)

Query: 13   YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
            YL++L   +  KFK  L+    +    P+P  + +KA   D+A L+      ++AW + +
Sbjct: 14   YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73

Query: 73   WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
             +F  INR+DL+ KA+ +                                          
Sbjct: 74   NLFLQINRKDLWTKAQEE------------------------------------------ 91

Query: 133  KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
             ++    YRK+++  FQ I ++   L               + EH  ++  + E   +  
Sbjct: 92   MRNKLNPYRKHMKETFQLIWEKETCLH--------------VPEHFYKETMKNEYKELND 137

Query: 193  TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
              T  +                     HTVV +G  GIGKT L RK+MLDWA G L++DR
Sbjct: 138  AYTAAARR-------------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDR 178

Query: 253  FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
            F ++F+++  E++ + + SL +L+    P+ +  I  I  +P RILF+MDGF++L+  F+
Sbjct: 179  FTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLK--FN 236

Query: 313  EHI-GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL 371
              +   L  DW++ +   I+LSSL++KK+LPE+SLLI    +A++K   +L HP+ +++L
Sbjct: 237  LQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296

Query: 372  GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKS 431
            GFSE+++K YF  +F ++++A   F+ +++N  LF +C  P  CW+VCT +KQ++E G+ 
Sbjct: 297  GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356

Query: 432  LAQTSKTTTAVYVFFLSSLLQPRGGSQEHG---LCAHLWGLCSLAADGIWNQKILFEESD 488
            L   S+ TT +Y  FL+++   + GSQ        A L  LC+LAA+GIW    +F   D
Sbjct: 357  LEINSQNTTYLYASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGD 414

Query: 489  LRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPG 548
            LR +GL +++   ++ M L Q+  DC   ++F+H+  QEF AAM+YLL+  K+      G
Sbjct: 415  LRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIG 471

Query: 549  SRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLEL 608
            S        +T L+       +  L  V  F+FG+  +E  S LE      +S+ ++ E+
Sbjct: 472  S--------ITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEI 523

Query: 609  LKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSF 668
             + +E  ++ +  +   +  ELF  L+E QE++FV + M++F ++ I +      +++SF
Sbjct: 524  TQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASF 583

Query: 669  CIENCHRVESLSLGFLHNMPKEE------EEE-------------EKEGRHLDMVQCVLP 709
            C+++C  + +L +   +  P +        E+              K  + LDM    L 
Sbjct: 584  CLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLD 643

Query: 710  SSSHAACSHGL------VNSHLTSSFCRG----LFSVLSTSQSLTELDLSDNSLGDPGMR 759
              S A     L      +   + +S   G    LF  +  +  L  L L   SL    +R
Sbjct: 644  DPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIR 703

Query: 760  VLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 819
             LCETL+HP C I  L LG+C +S E C DI+ VL+ N KL  L L +N L D G+ LLC
Sbjct: 704  HLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLC 763

Query: 820  VGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKA 879
              LKH  C L++L L+ CCLTS  C  ++ VL  S SL+ L +G NAL D+GVA LC   
Sbjct: 764  EALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAAL 823

Query: 880  KNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP 939
            K+P C++++L L+   LTS  C  +++VL  N  L  L L  N +GD G++ LC  L HP
Sbjct: 824  KHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHP 883

Query: 940  DCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
             CKL+ L L  C +T  CC D++  L + ++LR L+L    L    V++ CE L    C 
Sbjct: 884  HCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCA 943

Query: 1000 LQNLGLSEMYFNYETKSALETLQEEKPELTVVFEP 1034
            LQ LGL +  F+ ET+  L +++E+ P LT+   P
Sbjct: 944  LQMLGLHKSGFDEETQKILMSVEEKIPHLTISHGP 978


>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
          Length = 1062

 Score =  492 bits (1266), Expect = e-139
 Identities = 351/1068 (32%), Positives = 530/1068 (49%), Gaps = 82/1068 (7%)

Query: 10   LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
            L   LE L   +L KFK  +  +        +P  + +KAD   L  ++           
Sbjct: 11   LQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEM 70

Query: 70   MAVWIFAAINRRDLYEKAKRD--EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRI 127
             ++ +F  ++R DL E+AK +  E    S N R      I +++               +
Sbjct: 71   ASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKER------------PPL 118

Query: 128  SICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQEL 187
             + +M + ++ + + +  ++   I      LG+ V   K+  +    +     + RE   
Sbjct: 119  DVDEMLERFKTEAQAFTETKGNVI-----CLGKEVFKGKKPDKDNRCRYILKTKFREMWK 173

Query: 188  LAIGKTKTCESPVSPIKMELLFDPDDEHSEPV-HTVVFQGAAGIGKTILARKMMLDWASG 246
               G +K  +      KM + F        P  +TVV  G AG+GKT LA+K+MLDWA  
Sbjct: 174  SWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAED 233

Query: 247  TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
             L   +F Y FY+ CRE+S +   S  +L+    P+    I  I+ +  +ILF++DGFDE
Sbjct: 234  NLIH-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDE 292

Query: 307  LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
            L  A    I  +C DW+K +   +LL SL+ + +LP+A+LL+TTRP AL  L+ L + P 
Sbjct: 293  LGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPI 352

Query: 367  HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
            ++ + GF E  R+ YF ++F DE QA  AF L++ N  LF +   P VCWIVCT LK QM
Sbjct: 353  YIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQM 412

Query: 427  ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
            E G+    T  T T +++ FL S   P+G      L   L  L  LAA G+W Q  +   
Sbjct: 413  EKGEDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQTSVLHR 467

Query: 487  SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKE----G 542
             DL   G+Q++D+  FL  ++ +++   +  YSFIH++FQ+F  A++Y LE+E+E    G
Sbjct: 468  EDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDG 527

Query: 543  RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
             T   G        DV  LL    +     LI    + FGL N++R   LE    C++S 
Sbjct: 528  HTWDIG--------DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSP 579

Query: 603  QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
             I+ ELL+  ++  K     +   Q EL  CLYE QEE+ V+  M  F +I ++L+  +D
Sbjct: 580  DIKQELLR-CDISCKGGHSTVTDLQ-ELLGCLYESQEEELVKEVMAQFKEISLHLNA-VD 636

Query: 663  HMVSSFCIENCHRVESLSLGFL-HNMPKE--------EEEEEKEGRHL------------ 701
             + SSFC+++C  ++ +SL  +  N+P+         E E  ++ +H+            
Sbjct: 637  VVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFG 696

Query: 702  ---DMVQCVLPSSSHAACSHGLVNSHLTSSFC----------------RGLFSVLSTSQS 742
               D++   +  S  +A    ++   + S  C                R L   L   ++
Sbjct: 697  SNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKT 756

Query: 743  LTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVE 802
            +T L L  N   D     LCE L+HP CN+R L L  C  + +   D+SL L  NQ L  
Sbjct: 757  VTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTC 815

Query: 803  LDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYV 862
            ++LSDN L D G +LL   L+H  C L++L L +C LT A C+DLA+VL  S  LT L +
Sbjct: 816  VNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCL 875

Query: 863  GENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGN 922
             +N +G++GV  LCE  + P+C LQ L L N  +TS  C  L+ +L    +L  L L  N
Sbjct: 876  AKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLN 935

Query: 923  TLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLG 982
             +G KG+K LCE L  P C L+ L L  C++    C DL + L+ +QSL  L LG N LG
Sbjct: 936  HIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLG 995

Query: 983  DLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
              GV M  E L   S  L+ L L    FN E    LE ++E+ P+L +
Sbjct: 996  SSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 34/128 (26%), Positives = 58/128 (45%), Gaps = 2/128 (1%)

Query: 904  LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 963
            L S+  +N++L  L +  + L    +++LCE +    C LQ +   N +  +    +L  
Sbjct: 691  LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLCL 749

Query: 964  LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 1023
             L   +++  L+L  ND  D+   + CEVL+   C L+ LGL       +  + L    E
Sbjct: 750  ALRGHKTVTYLTLQGNDQDDMFPAL-CEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808

Query: 1024 EKPELTVV 1031
                LT V
Sbjct: 809  VNQSLTCV 816


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
            sapiens]
          Length = 1043

 Score =  485 bits (1249), Expect = e-137
 Identities = 330/1043 (31%), Positives = 524/1043 (50%), Gaps = 115/1043 (11%)

Query: 10   LARYLEDLEDVDLKKFKMHLEDYP-------PQKGCIPLPRGQTEKADHVDLATLMIDFN 62
            L  YL  L+   L++FK+ LE          PQ     +P      AD ++L+ L+ +  
Sbjct: 17   LLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEHF 76

Query: 63   GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVI--------------- 107
             + +AW + + IF  +N   L EK  R E K       + +PT                 
Sbjct: 77   PKGQAWKVVLGIFQTMNLTSLCEKV-RAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135

Query: 108  -CQE------DSIEEEW-----MGLLEYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRN 155
             CQ+      D +EEE       G  +          + D+R+KYR+ +++         
Sbjct: 136  GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAEL------- 188

Query: 156  ARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGKTKTCESPVSPIKMELLFDPDDEH 215
                +++S  K +  +R    + S+ E E+                   ++ L DP+   
Sbjct: 189  LETWDNISWPKDHVYIR----NTSKDEHEE-------------------LQRLLDPNRTR 225

Query: 216  SEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRSLGDL 275
            ++   T+V  G AG+GKT LA + ML WA+G L+Q RF Y+FY+ C ++  + + +  +L
Sbjct: 226  AQ-AQTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAEL 284

Query: 276  IMSCCPDPNPPIHKIVRKPSRILFLMDGFDEL------QGAFDEHIGPLCTDWQKAERGD 329
            I    PD + PI + + +P ++LF++DGF+E+        + D+  G  CTDW +     
Sbjct: 285  ISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDD--GSPCTDWYQELPVT 342

Query: 330  ILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDE 389
             +L SL++K+L+P A+LLIT +   +  L+  L +P  V+I GF+    + YF ++F D 
Sbjct: 343  KILHSLLKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDS 402

Query: 390  AQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSS 449
            ++       +++NE LF  C  P+VCW VC+ LKQ       L   ++TTT++Y +F S+
Sbjct: 403  SEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSN 462

Query: 450  LLQPRGGSQEHGLCAHLW-----GLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLR 504
            L      + E  L    W      LCSLA +G+W+    F + D    GL+   + +   
Sbjct: 463  LFS----TAEVDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYE 518

Query: 505  MNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLLEN 564
             N+ QK  DC    +F H++FQEFFAAM ++LEE +E     P    K   +++ +LL++
Sbjct: 519  FNILQKINDCGGCTTFTHLSFQEFFAAMSFVLEEPRE----FPPHSTK--PQEMKMLLQH 572

Query: 565  YGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQIQ 624
                ++ Y   VV F FGL+N+     LE  L CKIS ++  ELLKW E   KA+   +Q
Sbjct: 573  VLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQ 632

Query: 625  PSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLGFL 684
               L LF+CL+E QEEDF ++ +    ++++N+    +   SSFC+++C R+  L L   
Sbjct: 633  FHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVS 692

Query: 685  HNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLT 744
             ++ + + E             +L +S   +        H  +S C    S L T+++L 
Sbjct: 693  SHILERDLE-------------ILETSKFDS------RMHAWNSIC----STLVTNENLH 729

Query: 745  ELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELD 804
            ELDLS++ L    ++ LC  L++P C +++L   +         D+ + L  N KL  L+
Sbjct: 730  ELDLSNSKLHASSVKGLCLALKNPRCKVQKLTC-KSVTPEWVLQDLIIALQGNSKLTHLN 788

Query: 805  LSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGE 864
             S N LG   + L+   L+H  CNLK L L  C L++A CQDLA  L++   +TRL +G 
Sbjct: 789  FSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGF 847

Query: 865  NALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTL 924
            N L D G+ +LC    +P+C L++L L    L +  C  LS  L  N++LTHL L  N+L
Sbjct: 848  NRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSL 907

Query: 925  GDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDL 984
             D+G+K LCE L  PD  LQ L L  C+ T   C +L+  L+ + +++ L LG NDL D 
Sbjct: 908  RDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDD 967

Query: 985  GVMMFCEVLKQQSCLLQNLGLSE 1007
            GV + CE LK     L  LGL++
Sbjct: 968  GVKLLCEALKPHRA-LHTLGLAK 989



 Score =  124 bits (311), Expect = 5e-28
 Identities = 84/224 (37%), Positives = 116/224 (51%), Gaps = 2/224 (0%)

Query: 790  ISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLAS 849
            I   L +N+ L ELDLS++ L    ++ LC+ LK+  C ++KL   S        QDL  
Sbjct: 718  ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQDLII 776

Query: 850  VLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLS 909
             L  +  LT L    N LG + V ++ +  ++  CNL+ L L    L++  C  L+  L+
Sbjct: 777  ALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLT 835

Query: 910  TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 969
            + Q++T L L  N L D GIKLLC  L HP C L+ LEL  C L +  C  LS  L  ++
Sbjct: 836  SIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNR 895

Query: 970  SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYE 1013
            SL  L+L  N L D GV   CE L +    LQ+L LS   F  E
Sbjct: 896  SLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 11/102 (10%)

Query: 674  HRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGL 733
            H V+ L LG        E + + +G  L    C       A  + GL   +LT++ C+ L
Sbjct: 952  HNVKILDLG--------ENDLQDDGVKL---LCEALKPHRALHTLGLAKCNLTTACCQHL 1000

Query: 734  FSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRL 775
            FSVLS+S+SL  L+L  N L   G+++LC+ L+   C +++L
Sbjct: 1001 FSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042


>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 1429

 Score =  463 bits (1192), Expect = e-130
 Identities = 284/699 (40%), Positives = 395/699 (56%), Gaps = 50/699 (7%)

Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370

Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430

Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490

Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550

Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604

Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657

Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710

Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758

Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805

Query: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865

Query: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925

Query: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
            L + +N L D GV +LCE  ++P C L +LGL  + L+
Sbjct: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964



 Score =  148 bits (374), Expect = 2e-35
 Identities = 81/192 (42%), Positives = 114/192 (59%)

Query: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LGL +   + E +  L
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 1019 ETLQEEKPELTV 1030
              L++EKP+L +
Sbjct: 972  RALEQEKPQLLI 983



 Score =  136 bits (342), Expect = 1e-31
 Identities = 76/172 (44%), Positives = 101/172 (58%)

Query: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862

Query: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922

Query: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
           +L  L L+ N L D G++LLCEGL HP CKL  L LD   L+     +L  L
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67

Query: 69 AMAVWIFAAINRRDLYEKAK 88
           +A+  +  +  R L  +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87


>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
           sapiens]
          Length = 1375

 Score =  463 bits (1192), Expect = e-130
 Identities = 284/699 (40%), Positives = 395/699 (56%), Gaps = 50/699 (7%)

Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370

Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430

Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490

Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550

Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604

Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657

Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710

Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758

Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805

Query: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865

Query: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925

Query: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
            L + +N L D GV +LCE  ++P C L +LGL  + L+
Sbjct: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964



 Score =  148 bits (374), Expect = 2e-35
 Identities = 81/192 (42%), Positives = 114/192 (59%)

Query: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LGL +   + E +  L
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 1019 ETLQEEKPELTV 1030
              L++EKP+L +
Sbjct: 972  RALEQEKPQLLI 983



 Score =  136 bits (342), Expect = 1e-31
 Identities = 76/172 (44%), Positives = 101/172 (58%)

Query: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862

Query: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922

Query: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
           +L  L L+ N L D G++LLCEGL HP CKL  L LD   L+     +L  L
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67

Query: 69 AMAVWIFAAINRRDLYEKAK 88
           +A+  +  +  R L  +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87


>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 1473

 Score =  463 bits (1192), Expect = e-130
 Identities = 284/699 (40%), Positives = 395/699 (56%), Gaps = 50/699 (7%)

Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370

Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430

Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490

Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550

Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604

Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657

Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710

Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758

Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805

Query: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865

Query: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925

Query: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLT 897
            L + +N L D GV +LCE  ++P C L +LGL  + L+
Sbjct: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLS 964



 Score =  148 bits (374), Expect = 2e-35
 Identities = 81/192 (42%), Positives = 114/192 (59%)

Query: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 1018
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LGL +   + E +  L
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 1019 ETLQEEKPELTV 1030
              L++EKP+L +
Sbjct: 972  RALEQEKPQLLI 983



 Score =  136 bits (342), Expect = 1e-31
 Identities = 76/172 (44%), Positives = 101/172 (58%)

Query: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862

Query: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922

Query: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
           +L  L L+ N L D G++LLCEGL HP CKL  L LD   L+     +L  L
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67

Query: 69 AMAVWIFAAINRRDLYEKAK 88
           +A+  +  +  R L  +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score =  463 bits (1192), Expect = e-130
 Identities = 316/1045 (30%), Positives = 519/1045 (49%), Gaps = 65/1045 (6%)

Query: 14   LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
            L +L+  + + FK  L+    +     +P+ + E A+   LA L+ ++ G   AWA ++ 
Sbjct: 69   LYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWATSIS 128

Query: 74   IFAAINRRDLYEKAKRD-------EPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSR 126
            IF  +N R L EKA+ D       +P+    +   S   V     +++++     E   +
Sbjct: 129  IFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAETKEQ 188

Query: 127  ISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQE 186
                 M+++         +   Q +E   A   E+             K H   +  E+E
Sbjct: 189  EISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDY-KSHVMTKFAEEE 247

Query: 187  LLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASG 246
             +      T         +   FD D     P  TVV  G +GIGK+ LAR+++L WA G
Sbjct: 248  DVRRSFENTAADWPEMQTLAGAFDSDRWGFRP-RTVVLHGKSGIGKSALARRIVLCWAQG 306

Query: 247  TLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDE 306
             LYQ  F Y+F++  RE+    + S+ + I    PD   P+ +I+ +P R+LF++DGFD+
Sbjct: 307  GLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDD 366

Query: 307  LQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPR 366
            L G+   +   LC DW + +    L+ SL+RK LLPE+ L++T R V  EKL+  +  PR
Sbjct: 367  L-GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPR 425

Query: 367  HVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQM 426
            ++ + G S  +R     +    E Q       I  N  L   C +P V  ++C  L+ Q 
Sbjct: 426  YLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQD 485

Query: 427  ESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH------LWGLCSLAADGIWNQ 480
              G+S+A  ++T T ++  F+   L PRG  +    C +      L   C +A +G+WN+
Sbjct: 486  VVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRR---CLNLEERVVLKRFCRMAVEGVWNR 542

Query: 481  KILFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEK 540
            K +F+  DL   GL ++++ A   MN+   +  CE++Y+F H++ Q+F AA+YY+LE  +
Sbjct: 543  KSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEGLE 602

Query: 541  EGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKI 600
                  P   L +     ++ L+  G     + +++ RFLFGLV+++    LE  L C +
Sbjct: 603  IEPALCP---LYVEKTKRSMELKQAGFHI--HSLWMKRFLFGLVSEDVRRPLEVLLGCPV 657

Query: 601  SQQIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTR 660
               ++ +LL W+ +  +          L+ F+CL+E Q+++FV+ A++ F ++ + ++  
Sbjct: 658  PLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQN 717

Query: 661  MDHMVSSFCIENCHRVESLSLGFLHNMPKEEE-----------------EEEKE------ 697
            +D + SSFC+++C  +  + +      P++E                  EE+ E      
Sbjct: 718  LDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSML 777

Query: 698  GRHLDMVQCVLPSS--------------SHAACSHGLV---NSHLTSSFCRGLFSVLSTS 740
            G H  + Q  L SS               H  C    +   N+ +T    + L+ ++  +
Sbjct: 778  GTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPG-VQHLWRIVMAN 836

Query: 741  QSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKL 800
            ++L  L+L    L +  +R+ CE L+HP C +  L L  CGL+H C   IS +L+++  L
Sbjct: 837  RNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSL 896

Query: 801  VELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRL 860
              L L+ N + D G+  L   L+   C L+KL L  C +T+  CQ LAS L ++ SLT L
Sbjct: 897  KSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHL 956

Query: 861  YVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLR 920
             +  N+LG+ GV +LC   + P C+LQ+L L    L +  C  L+  L  N  LTHL L 
Sbjct: 957  CLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLS 1016

Query: 921  GNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNND 980
             N + D G+KLLCE +  P C LQ LEL  C+LT+ CC  LS +++ S+ L+ L L +N 
Sbjct: 1017 MNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNA 1076

Query: 981  LGDLGVMMFCEVLKQQSCLLQNLGL 1005
            LGD GV   CE LKQ++ +L  LGL
Sbjct: 1077 LGDGGVAALCEGLKQKNSVLARLGL 1101



 Score =  196 bits (497), Expect = 1e-49
 Identities = 127/361 (35%), Positives = 189/361 (52%), Gaps = 12/361 (3%)

Query: 676  VESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTSSFCRGLFS 735
            + SL+LG  H    +EE+       L   +C+L S     C        LT +    +  
Sbjct: 839  LRSLNLGGTH---LKEEDVRMACEALKHPKCLLESLRLDCCG-------LTHACYLKISQ 888

Query: 736  VLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLS 795
            +L+TS SL  L L+ N + D G+  L + L+   C +++L L  CG++   C  ++  L 
Sbjct: 889  ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948

Query: 796  SNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSH 855
            SN+ L  L LS+N+LG+ G+ LLC  ++   C+L++L L  C L +A C  LA  L  + 
Sbjct: 949  SNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNS 1008

Query: 856  SLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLT 915
             LT L +  N + D+GV +LCE  + P C+LQ L LV   LT+ CC +LS V+S +++L 
Sbjct: 1009 WLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLK 1068

Query: 916  HLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLS 975
             L L  N LGD G+  LCEGL   +  L  L L  C LTS CC  LS  L+ ++ L  L+
Sbjct: 1069 SLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLN 1128

Query: 976  LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEPS 1035
            L  N+    G+M  C      +  LQ +GL +  +  + +  LE +Q  KP   VV + S
Sbjct: 1129 LVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPR--VVIDGS 1186

Query: 1036 W 1036
            W
Sbjct: 1187 W 1187



 Score =  129 bits (325), Expect = 1e-29
 Identities = 77/242 (31%), Positives = 127/242 (52%), Gaps = 1/242 (0%)

Query: 770  CNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNL 829
            C +  LW+    L  E   D   +L ++  L +LDL  + L +  ++ LC  L+H  C +
Sbjct: 753  CPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKI 812

Query: 830  KKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKL 889
            + L   +  +T    Q L  ++  + +L  L +G   L +  V + CE  K+P+C L+ L
Sbjct: 813  QTLMFRNAQITPGV-QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESL 871

Query: 890  GLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELD 949
             L   GLT  C   +S +L+T+ +L  L L GN + D+G+  L + L    C LQ L L+
Sbjct: 872  RLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILE 931

Query: 950  NCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMY 1009
            +C +T+  C  L++ L S++SL  L L NN LG+ GV + C  ++   C LQ L L++ +
Sbjct: 932  DCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCH 991

Query: 1010 FN 1011
             +
Sbjct: 992  LD 993


>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
           sapiens]
          Length = 1399

 Score =  461 bits (1187), Expect = e-129
 Identities = 282/692 (40%), Positives = 391/692 (56%), Gaps = 50/692 (7%)

Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370

Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430

Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490

Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550

Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604

Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657

Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710

Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758

Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805

Query: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865

Query: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925

Query: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLG 890
            L + +N L D GV +LCE  ++P C L +LG
Sbjct: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957



 Score =  133 bits (334), Expect = 1e-30
 Identities = 78/186 (41%), Positives = 108/186 (58%), Gaps = 1/186 (0%)

Query: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862

Query: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922

Query: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972
           +L  L L+ N L D G++LLCEGL HP CKL  L   +  +T     D   +  S+ SL+
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLK 981

Query: 973 KLSLGN 978
           +  LG+
Sbjct: 982 RQRLGS 987



 Score =  132 bits (331), Expect = 2e-30
 Identities = 73/166 (43%), Positives = 99/166 (59%)

Query: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LG
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 896  LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955
            +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 956  HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015
              C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 1016 SALETLQEEKPEL 1028
              L ++    P L
Sbjct: 912  QDLASVLSASPSL 924



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67

Query: 69 AMAVWIFAAINRRDLYEKAK 88
           +A+  +  +  R L  +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87


>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
           sapiens]
          Length = 1443

 Score =  461 bits (1187), Expect = e-129
 Identities = 282/692 (40%), Positives = 391/692 (56%), Gaps = 50/692 (7%)

Query: 203 IKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCR 262
           I++  LF P  +  EP   V+ QGAAGIGK+ LAR++   W  G LY DRF ++FY  CR
Sbjct: 312 IEIRDLFGPGLDTQEP-RIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCR 370

Query: 263 EVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDW 322
           E++     SL +LI         PI +I+ +P R+LF++DG DE      E    LC  W
Sbjct: 371 ELAQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHW 430

Query: 323 QKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYF 382
            + +  D LL SL+ K +LPEAS LIT R  AL+ L   L+  R VE+LGFSE+ RKEYF
Sbjct: 431 SQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYF 490

Query: 383 FKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAV 442
           ++YF+DE QA  AF L++ N+ L+ +C +P V W+ CT L QQM+  + L  TSKTTT +
Sbjct: 491 YRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTL 550

Query: 443 YVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAF 502
            + +L+  LQ +       L   L  LCSLAA+GIW +K LF   DLR HGL  A +S F
Sbjct: 551 CLHYLAQALQAQP------LGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTF 604

Query: 503 LRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTVLL 562
           L+M + Q E      YSFIH+ FQEFFAAM Y+LE+EK GR       +     D+   L
Sbjct: 605 LKMGILQ-EHPIPLSYSFIHLCFQEFFAAMSYVLEDEK-GRGKHSNCII-----DLEKTL 657

Query: 563 ENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKKLQ 622
           E YG     +     RFL GL++ E    +E    C++SQ     L++W+     + +L 
Sbjct: 658 EAYG-IHGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVP----SLQLL 710

Query: 623 IQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRVESLSLG 682
           +QP  LE  +CLYE + + F+ + M +F ++ + + T M+ +V +FCI            
Sbjct: 711 LQPHSLESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCI------------ 758

Query: 683 FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH----LTSSFCRGLFSVLS 738
                        K  RH+  +Q +      +  S  +V       +T ++ + LFSVL 
Sbjct: 759 -------------KFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLK 805

Query: 739 TSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQ 798
            +++L ELDLS NSL    ++ LC+TL+ P C +  L L  CGL+ E C D++  L +NQ
Sbjct: 806 VTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ 865

Query: 799 KLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLT 858
            L ELDLS N L D G + LC  L+   C L++L LVSC LTS CCQDLASVLS S SL 
Sbjct: 866 TLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLK 925

Query: 859 RLYVGENALGDSGVAILCEKAKNPQCNLQKLG 890
            L + +N L D GV +LCE  ++P C L +LG
Sbjct: 926 ELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957



 Score =  133 bits (334), Expect = 1e-30
 Identities = 78/186 (41%), Positives = 108/186 (58%), Gaps = 1/186 (0%)

Query: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852
           VL   + L ELDLS N+L    ++ LC  L+   C L+ L L  C LT+  C+DLA  L 
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862

Query: 853 TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912
            + +LT L +  N L D+G   LC++ + P C LQ+L LV+ GLTS CC  L+SVLS + 
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922

Query: 913 NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972
           +L  L L+ N L D G++LLCEGL HP CKL  L   +  +T     D   +  S+ SL+
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDTGEMSNSTSSLK 981

Query: 973 KLSLGN 978
           +  LG+
Sbjct: 982 RQRLGS 987



 Score =  132 bits (331), Expect = 2e-30
 Identities = 73/166 (43%), Positives = 99/166 (59%)

Query: 839  LTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTS 898
            +T A  Q L SVL  + +L  L +  N+L  S V  LC+  + P+C L+ L L   GLT+
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 899  VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 958
              C  L+  L  NQ LT L L  N L D G K LC+ L  P CKLQ L+L +C LTS CC
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 959  WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
             DL+++L++S SL++L L  N+L D+GV + CE L+  +C L  LG
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 48/133 (36%), Positives = 65/133 (48%)

Query: 896  LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 955
            +T      L SVL   +NL  L L GN+L    +K LC+ L  P C L+ L L  C LT+
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 956  HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 1015
              C DL+  L ++Q+L +L L  N L D G    C+ L+Q SC LQ L L       +  
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 1016 SALETLQEEKPEL 1028
              L ++    P L
Sbjct: 912  QDLASVLSASPSL 924



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 9  KLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
          +LA YLE L+  +LK+F++ L +    +        Q EK   +++A+ ++   GE++AW
Sbjct: 8  RLACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAW 67

Query: 69 AMAVWIFAAINRRDLYEKAK 88
           +A+  +  +  R L  +A+
Sbjct: 68 DLALHTWEQMGLRSLCAQAQ 87


>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
            [Homo sapiens]
          Length = 1009

 Score =  446 bits (1148), Expect = e-125
 Identities = 338/1043 (32%), Positives = 506/1043 (48%), Gaps = 82/1043 (7%)

Query: 10   LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
            L   LE L + +LK FK  L  +P +      P  + E+AD   LA ++++ + E     
Sbjct: 10   LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69

Query: 70   MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
              V I   +N  +L + AK +  + G             Q   I+   +G  E  S ++ 
Sbjct: 70   ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116

Query: 130  CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
               K+ +R    K                 +S+     + +  +   H     R Q  + 
Sbjct: 117  PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159

Query: 190  IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
                    +P +P K+              +TVV  G AG+GKT LA+K MLDW    L 
Sbjct: 160  F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200

Query: 250  QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
                 Y FY+ C+E+S +   S  +LI    P+    I  I+ +  RILF++DG DEL+ 
Sbjct: 201  SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260

Query: 310  AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
                 I  +C DW+K +   +LL SL+++K+LP A+LL+TTRP AL  LQ L   P +V 
Sbjct: 261  PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320

Query: 370  ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
            + GF E  R+ YF ++F DE QA  AF L++ N  LF +   P VCWIVCT LK QME G
Sbjct: 321  VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380

Query: 430  KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
            +    T  T T +++ FL S   P+G      L   L  L  LAA G+W Q  +F   DL
Sbjct: 381  EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435

Query: 490  RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
               G+Q++D+  FL  ++ +++   +  YSFIH++FQ+F  A++Y LE+E EG     G 
Sbjct: 436  ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493

Query: 550  RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
               +   DV  LL    + +   LI V  FLFGL N++R   LE    C++S  I+ ELL
Sbjct: 494  AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551

Query: 610  KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
            +  +    A K        E+  CLYE QEE+  +  +  F +I I+L+   + M  SF 
Sbjct: 552  Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610

Query: 670  IENCHRVESLSLG-----FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH 724
            +++C  ++ LSL      FL N    E + E E  + ++    +  S  +  S  ++  H
Sbjct: 611  LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDH 670

Query: 725  LTSSFC----------------RGLFSVLSTSQSLTELDLSDNSLGDPGMR-VLCETLQH 767
            +T S C                R         ++LT L L+ +   +  M  +LC+ L++
Sbjct: 671  VTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 730

Query: 768  PGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLC 827
              CN++ L LG    + E   +   VL +NQ L  L LS N L D G  LL   +     
Sbjct: 731  HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 790

Query: 828  NLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQ 887
             L+ L L +C LT A C+DLA+VL  S  LT L + +N +GD+GV  LCE    P C LQ
Sbjct: 791  FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 850

Query: 888  KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLE 947
             L L    +T + C  LS  L    +LT+L L  N +  +G+ +LC+ L +P+C L+ L 
Sbjct: 851  TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLR 909

Query: 948  LDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
            L +C+L    C  L + L S+Q L  L LG N L   G++    VL+Q++  L+ L L  
Sbjct: 910  LWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKT 969

Query: 1008 MYFNYETKSALETLQEEKPELTV 1030
               N E K  LE ++E+ P+LT+
Sbjct: 970  YETNLEIKKLLEEVKEKNPKLTI 992


>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform 2
            [Homo sapiens]
          Length = 980

 Score =  438 bits (1126), Expect = e-122
 Identities = 328/1028 (31%), Positives = 501/1028 (48%), Gaps = 81/1028 (7%)

Query: 10   LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
            L   LE L + +LK FK  L  +P +      P  + E+AD   LA ++++ + E     
Sbjct: 10   LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69

Query: 70   MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
              V I   +N  +L + AK +  + G             Q   I+   +G  E  S ++ 
Sbjct: 70   ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116

Query: 130  CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
               K+ +R    K                 +S+     + +  +   H     R Q  + 
Sbjct: 117  PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159

Query: 190  IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
                    +P +P K+              +TVV  G AG+GKT LA+K MLDW    L 
Sbjct: 160  F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200

Query: 250  QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
                 Y FY+ C+E+S +   S  +LI    P+    I  I+ +  RILF++DG DEL+ 
Sbjct: 201  SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260

Query: 310  AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
                 I  +C DW+K +   +LL SL+++K+LP A+LL+TTRP AL  LQ L   P +V 
Sbjct: 261  PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320

Query: 370  ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
            + GF E  R+ YF ++F DE QA  AF L++ N  LF +   P VCWIVCT LK QME G
Sbjct: 321  VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380

Query: 430  KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
            +    T  T T +++ FL S   P+G      L   L  L  LAA G+W Q  +F   DL
Sbjct: 381  EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435

Query: 490  RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
               G+Q++D+  FL  ++ +++   +  YSFIH++FQ+F  A++Y LE+E EG     G 
Sbjct: 436  ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493

Query: 550  RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
               +   DV  LL    + +   LI V  FLFGL N++R   LE    C++S  I+ ELL
Sbjct: 494  AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551

Query: 610  KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
            +  +    A K        E+  CLYE QEE+  +  +  F +I I+L+   + M  SF 
Sbjct: 552  Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610

Query: 670  IENCHRVESLSLG-----FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH 724
            +++C  ++ LSL      FL N    E + E E       +C   +  + A    L +  
Sbjct: 611  LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE-------RCTYLTIPNWA-RQDLRSLR 662

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            L + FC    S+ S++ +L  L++  + L D  +R+LC+ +    C+++++ +    ++ 
Sbjct: 663  LWTDFC----SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIK--NVTP 716

Query: 785  ECCF-DISLVLSSNQKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVSCCLTSA 842
            +  + D  L     + L  L L+ +   +  + L LC  L++  CNL+ L L   C T  
Sbjct: 717  DTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPE 776

Query: 843  CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCS 902
               +   VL  + SL  L +  N L D G  +L +    P+  LQ L L N  LT   C 
Sbjct: 777  QWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCK 836

Query: 903  ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS 962
             L++VL  ++ LTHL L  N +GD G+K LCEGL +PDCKLQ L L  C++T   C  LS
Sbjct: 837  DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 896

Query: 963  TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQ 1022
              L  + SL  L L  N +   G+ + C+ L+  +C L++L L     N E K  LE ++
Sbjct: 897  EALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVK 955

Query: 1023 EEKPELTV 1030
            E+ P+LT+
Sbjct: 956  EKNPKLTI 963


>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
          Length = 1048

 Score =  435 bits (1118), Expect = e-121
 Identities = 317/1028 (30%), Positives = 496/1028 (48%), Gaps = 107/1028 (10%)

Query: 13   YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
            Y+ ++   +L++FK  L       G +P+   Q E A   ++  L+I+     +AW +  
Sbjct: 44   YMRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTS 102

Query: 73   WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
             IFA +N   +    +R+       NA +  PT+  ++ ++ E         +++++ + 
Sbjct: 103  NIFAIMNCDKMCVVVRREI------NAIL--PTLEPEDLNVGE---------TQVNLEEG 145

Query: 133  KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
            +    ++Y+  V  +F  I D     G     N+R    + +  H               
Sbjct: 146  ESGKIRRYKSNVMEKFFPIWDITTWPG-----NQRDFFYQGVHRHEEY------------ 188

Query: 193  TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
                        +  L  P         TV  QGA GIGKTILA+K+M +WA    Y  +
Sbjct: 189  ------------LPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHK 236

Query: 253  FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
                FY HC+EV+  T +S  +LI    P     + KI+ KP ++L L+DGF+EL     
Sbjct: 237  RWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLI 296

Query: 313  EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
            + +  L  DW++   G +LLSSL+ K +LPEA+LLI  R  + +  + LL  P  V + G
Sbjct: 297  DRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPG 356

Query: 373  FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
            F+  ++ +YF  YF    +     S   EN +LF+MC +P+VCW+VC+GLKQQME G +L
Sbjct: 357  FNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNL 416

Query: 433  AQTSKTTTAVYVFFLSSLLQPRGGSQEHGL-CAHLWGLCSLAADGIWNQKILFEESDLRN 491
             Q+    T+V+V ++SSL   R  +    +  A L GLC LAAD +W++K +  + DL  
Sbjct: 417  TQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEE 476

Query: 492  HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
              L +  V+AFL M++ ++    E  Y F  +TFQEFFAA++Y+L             RL
Sbjct: 477  AKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVL---------CFPQRL 527

Query: 552  K----LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
            K    L   ++  L+ +  +  K YL  +  FLFG +N+   S +E+   CK+S   + +
Sbjct: 528  KNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRK 586

Query: 608  LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
            LLK I +  K           +LFYCL+E++EE FV +A++ + K+ + +    +  VS+
Sbjct: 587  LLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSA 646

Query: 668  FCIENC---HRVE-SLSLGFLH------NMPKEEEEEEKEGRH----------------- 700
            FC++ C   H VE +++L F++      +     E  E  G H                 
Sbjct: 647  FCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLE 706

Query: 701  -LDMVQCVL---------PSSSHAACS-HGLVNSHLTSSFC-RGLFSVLSTSQSLTELDL 748
             L M   VL          +  H  C    L+   + S+   + L  VL+ +Q L  L++
Sbjct: 707  VLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEI 766

Query: 749  SDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDN 808
                +    +++LC  L+ P C ++ L L  C  +     D+   L  N  L  L L  N
Sbjct: 767  QHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKN 826

Query: 809  ALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALG 868
            +L + G   L V        L++L + +C LT   C+ LAS L  S  LT L + ENAL 
Sbjct: 827  SLENCGAYYLSV------AQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALK 880

Query: 869  DSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKG 928
            D G   +     + +C LQ+L L    LT  CC  + S L  N+ L  L L  N+L D G
Sbjct: 881  DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940

Query: 929  IKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMM 988
            + LLCE L +PDC LQ+LEL+NC  TS CC  ++++L  +Q LR L L  N +G  G++ 
Sbjct: 941  VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILT 1000

Query: 989  FCEVLKQQ 996
             CE    Q
Sbjct: 1001 LCEAFSSQ 1008


>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
            3 [Homo sapiens]
          Length = 1037

 Score =  433 bits (1114), Expect = e-121
 Identities = 342/1071 (31%), Positives = 510/1071 (47%), Gaps = 110/1071 (10%)

Query: 10   LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
            L   LE L + +LK FK  L  +P +      P  + E+AD   LA ++++ + E     
Sbjct: 10   LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69

Query: 70   MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
              V I   +N  +L + AK +  + G             Q   I+   +G  E  S ++ 
Sbjct: 70   ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116

Query: 130  CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
               K+ +R    K                 +S+     + +  +   H     R Q  + 
Sbjct: 117  PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159

Query: 190  IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
                    +P +P K+              +TVV  G AG+GKT LA+K MLDW    L 
Sbjct: 160  F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200

Query: 250  QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
                 Y FY+ C+E+S +   S  +LI    P+    I  I+ +  RILF++DG DEL+ 
Sbjct: 201  SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260

Query: 310  AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
                 I  +C DW+K +   +LL SL+++K+LP A+LL+TTRP AL  LQ L   P +V 
Sbjct: 261  PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320

Query: 370  ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
            + GF E  R+ YF ++F DE QA  AF L++ N  LF +   P VCWIVCT LK QME G
Sbjct: 321  VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380

Query: 430  KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
            +    T  T T +++ FL S   P+G      L   L  L  LAA G+W Q  +F   DL
Sbjct: 381  EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435

Query: 490  RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
               G+Q++D+  FL  ++ +++   +  YSFIH++FQ+F  A++Y LE+E EG     G 
Sbjct: 436  ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493

Query: 550  RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
               +   DV  LL    + +   LI V  FLFGL N++R   LE    C++S  I+ ELL
Sbjct: 494  AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551

Query: 610  KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
            +  +    A K        E+  CLYE QEE+  +  +  F +I I+L+   + M  SF 
Sbjct: 552  Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610

Query: 670  IENCHRVESLSLG-----FLHN-MPKEEEEEEKEGRHLDMVQ---------------CVL 708
            +++C  ++ LSL      FL N M  E + E +   +L +                 C L
Sbjct: 611  LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670

Query: 709  PSSSH------------AACSHGLVNSHLTSSFC----------------RGLFSVLSTS 740
             SS+             +  S  ++  H+T S C                R         
Sbjct: 671  FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730

Query: 741  QSLTELDLSDNSLGDPGMR-VLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
            ++LT L L+ +   +  M  +LC+ L++  CN++ L LG    + E   +   VL +NQ 
Sbjct: 731  KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790

Query: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
            L  L LS N L D G  LL   +      L+ L L +C LT A C+DLA+VL  S  LT 
Sbjct: 791  LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850

Query: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
            L + +N +GD+GV  LCE    P C LQ L L    +T + C  LS  L    +LT+L L
Sbjct: 851  LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910

Query: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
              N +  +G+ +LC+ L +P+C L+ L L +C+L    C  L + L S+Q L  L LG N
Sbjct: 911  SINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQN 969

Query: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
             L   G++    VL+Q++  L+ L L     N E K  LE ++E+ P+LT+
Sbjct: 970  HLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020


>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
          Length = 892

 Score =  405 bits (1042), Expect = e-113
 Identities = 295/902 (32%), Positives = 449/902 (49%), Gaps = 104/902 (11%)

Query: 2   KMASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61
           ++A  R  L   LE+L    LK+F+  L D  P    IP   G+ E+AD VDLA  +  F
Sbjct: 14  RLAVARELLLAALEELSQEQLKRFRHKLRDVGPDGRSIPW--GRLERADAVDLAEQLAQF 71

Query: 62  NGEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLL 121
            G E A  +A       + RD+  +                      QE  ++   +G  
Sbjct: 72  YGPEPALEVARKTLKRADARDVAAQ---------------------LQERRLQRLGLGSG 110

Query: 122 EYLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQ 181
             LS         +Y+KKYR++V      +++RNAR   SV + KR+T+L +  E  + +
Sbjct: 111 TLLS-------VSEYKKKYREHVLQLHARVKERNAR---SVKITKRFTKLLIAPESAAPE 160

Query: 182 ER--EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKM 239
           E     E    G+ +  ++         LF  D+E   P+ TVV QG AGIGKT+ A+K+
Sbjct: 161 EALGPAEEPEPGRARRSDTHT----FNRLFRRDEEGRRPL-TVVLQGPAGIGKTMAAKKI 215

Query: 240 MLDWASGTLYQDRFDYLFYIHCRE-VSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRIL 298
           + DWA+G LYQ + D+ F++ C E +     RSL DLI+  CPD   P+ +++ +P R+L
Sbjct: 216 LYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPDRGAPVPQMLAQPQRLL 275

Query: 299 FLMDGFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKL 358
           F++DG DEL         P CTD  +A  G  +L  L+ K LLP A LL+TTR  A  +L
Sbjct: 276 FILDGADELPALGGPEAAP-CTDPFEAASGARVLGGLLSKALLPTALLLVTTRAAAPGRL 334

Query: 359 QHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIV 418
           Q  L  P+  E+ GFS+  +K+YF+K+F DE +A  A+  ++ENE LF +CF+P VCWIV
Sbjct: 335 QGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENETLFALCFVPFVCWIV 394

Query: 419 CTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIW 478
           CT L+QQ+E G+ L++TSKTTT+VY+ F++S+L     +    L   L  LC LA +G+ 
Sbjct: 395 CTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRLQGDLRNLCRLAREGVL 454

Query: 479 NQKILFEESDLRNHGLQKADV-SAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLE 537
            ++  F E +L    L+ + V + FL        ++ E  Y FI  +FQEF AA+ YLLE
Sbjct: 455 GRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFIDQSFQEFLAALSYLLE 514

Query: 538 EEKEGRTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLS 597
           +    RT   G         V  LL    +    +L+   RFLFGL++ ER   +E+   
Sbjct: 515 DGGVPRTAAGG---------VGTLLRGDAQ-PHSHLVLTTRFLFGLLSAERMRDIERHFG 564

Query: 598 CKISQQIRLELLKWI------------EVKAKAKKLQ--IQPSQ----------LELFYC 633
           C +S++++ E L+W+            EV   AK L+   +P +          LEL YC
Sbjct: 565 CMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYC 624

Query: 634 LYEMQEEDFVQRAMDYFPKIEIN--LSTRMDHMVSSFCIENCHRVESLSLGFLHNMPKEE 691
           LYE QE+ FV++A+  FP++ +      RMD  V S+C+  C   ++L L     +  +E
Sbjct: 625 LYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQE 684

Query: 692 EEEEKEGRHLD-----------------------MVQCVLPSSSHAACSHGLVNSHLTSS 728
           ++++  G+ L                        + Q +     H + S  L +  L  +
Sbjct: 685 KKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLS-SLTLSHCKLPDA 743

Query: 729 FCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCF 788
            CR L   L  + +LTEL L  N L + G+R+L E L  P C ++ + +          +
Sbjct: 744 VCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQY 803

Query: 789 DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLA 848
            + + L  +  L  LDLS   L    +  LC  L+H  C L+ L L S  L+    Q+L 
Sbjct: 804 LVGM-LRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQ 862

Query: 849 SV 850
           +V
Sbjct: 863 AV 864



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 46/156 (29%), Positives = 73/156 (46%), Gaps = 1/156 (0%)

Query: 875  LCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 934
            L +   +P C+L  L L +  L    C  LS  L     LT L L  N L + G+++L E
Sbjct: 719  LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778

Query: 935  GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 994
            GL  P C++Q + +   +      + L  +L  S +L  L L    L    V   C VL+
Sbjct: 779  GLAWPQCRVQTVRVQLPDPQRGLQY-LVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837

Query: 995  QQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 1030
             Q C LQ L L+ +  + ++   L+ ++  KP+L +
Sbjct: 838  HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 47/150 (31%), Positives = 67/150 (44%), Gaps = 9/150 (6%)

Query: 826 LCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCN 885
           LC+L  L L  C L  A C+DL+  L  + +LT L +  N L ++G+ +L E    PQC 
Sbjct: 727 LCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCR 786

Query: 886 LQ----KLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 941
           +Q    +L     GL       L  +L  +  LT L L G  L    +  LC  L H  C
Sbjct: 787 VQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGC 841

Query: 942 KLQVLELDNCNLTSHCCWDLSTLLTSSQSL 971
            LQ L L +  L+     +L  +  +   L
Sbjct: 842 GLQTLSLASVELSEQSLQELQAVKRAKPDL 871



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 25/69 (36%), Positives = 34/69 (49%)

Query: 733 LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISL 792
           L  +L  S +LT LDLS   L  P +  LC  LQH GC ++ L L    LS +   ++  
Sbjct: 804 LVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQA 863

Query: 793 VLSSNQKLV 801
           V  +   LV
Sbjct: 864 VKRAKPDLV 872


>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
          Length = 1033

 Score =  382 bits (982), Expect = e-106
 Identities = 267/870 (30%), Positives = 414/870 (47%), Gaps = 61/870 (7%)

Query: 205  MELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREV 264
            ++L +D    +S     V   G    GKTI+    +L W  G ++Q+   Y+ ++   E+
Sbjct: 132  LQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEI 191

Query: 265  SLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTDWQK 324
            + +T  SL +LI    PD   PI  I+  P ++LF+++  D ++   + +   LC++  +
Sbjct: 192  NQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQ 251

Query: 325  AERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFK 384
                 +LL SL+++K+ P    LI++RP     ++  L        L  S  KR+ YF  
Sbjct: 252  KVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNS 311

Query: 385  YFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYV 444
            +F D  +A AA  L+ E+E+L  +C + ++CWI CT LK+QM+ G+      +T T ++ 
Sbjct: 312  FFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHA 371

Query: 445  FFLSSLLQPRGG---SQEH-GLCAHLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVS 500
             FL+  L    G   +Q H GL   L  LC LAA G++   + F   DLR  G  +ADVS
Sbjct: 372  HFLADALTSEAGLTANQYHLGL---LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVS 428

Query: 501  AFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRLKLPSRDVTV 560
                 N+       +  Y FIH+  QEF  A+ +L+         VP   +   SR+   
Sbjct: 429  VLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMA--------VPNYLIPSGSREYKE 480

Query: 561  LLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKWIEVKAKAKK 620
              E Y  F +     V  F+FGL+N  R   LE     ++     ++  KW  V    K 
Sbjct: 481  KREQYSDFNQ-----VFTFIFGLLNANRRKILETSFGYQLPM---VDSFKWYSV-GYMKH 531

Query: 621  LQIQPSQL----ELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIENCHRV 676
            L   P +L     LFYCLYE +EE+FV+  +D   ++ + L +  D MVS +C++ C  +
Sbjct: 532  LDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCCHL 591

Query: 677  ESLSLGFLHNMPKEEE----------------------EEEKEGRHLDMVQCVLPSSSHA 714
             +L L        +E                          +  R L +    L   S  
Sbjct: 592  RTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISER 651

Query: 715  ACSHGLVNSHL-----------TSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCE 763
              S  L +S             T+S    L   L+ ++SLT L ++  S+      +L +
Sbjct: 652  ILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHD 711

Query: 764  TLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLK 823
             L  P C I  L L +C L    C +I+ +L S   L +L LS N L   G+ +LC  L 
Sbjct: 712  ILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALL 771

Query: 824  HLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQ 883
            H  C L  L LV CCLT  CC  L  VL  S +L +L +  N L + GV  +      P 
Sbjct: 772  HPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPT 831

Query: 884  CNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKL 943
            C L++L L     +S  C  ++ V++TN+ L  L +  N + D G++LLC GL HP+C L
Sbjct: 832  CQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCML 891

Query: 944  QVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNL 1003
              + L+ C LTS CC  L+++LT++++L +L+L  N LG+ GV    E L    C+L+ +
Sbjct: 892  VNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVV 951

Query: 1004 GLSEMYFNYETKSALETLQEEKPELTVVFE 1033
            GL     N +T+  L T++E KP L  + E
Sbjct: 952  GLPLTGLNTQTQQLLMTVKERKPSLIFLSE 981



 Score =  163 bits (412), Expect = 9e-40
 Identities = 104/300 (34%), Positives = 154/300 (51%), Gaps = 6/300 (2%)

Query: 720  LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
            L+   L +S C  + S+L +  SL +L LS N L   GM +LC+ L HP C +  L L  
Sbjct: 725  LMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVF 784

Query: 780  CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 839
            C L+  CC  +  VL  +  L +LDL  N L ++G+  +   L    C L++L L  C  
Sbjct: 785  CCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFF 844

Query: 840  TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 899
            +S  CQ +A V++T+  L  L +G N + D+G+ +LC   ++P C L  +GL    LTS 
Sbjct: 845  SSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSA 904

Query: 900  CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 959
            CC +L+SVL+TN+ L  L L  N LG+ G+  L E L+ PDC L+V+ L    L +    
Sbjct: 905  CCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQ 964

Query: 960  DLSTLLTSSQSLRKLS--LGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 1017
             L T+     SL  LS      +  ++GV        Q   ++ N  L  M+F +   SA
Sbjct: 965  LLMTVKERKPSLIFLSETWSLKEGREIGV----TPASQPGSIIPNSNLDYMFFKFPRMSA 1020


>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
          Length = 655

 Score =  356 bits (914), Expect = 6e-98
 Identities = 236/639 (36%), Positives = 347/639 (54%), Gaps = 86/639 (13%)

Query: 14  LEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAVW 73
           L DLE+ D KK K +L D    +G  PL RG+ E    VDLA L+I   GE++A  + + 
Sbjct: 17  LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76

Query: 74  IFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRIS-ICKM 132
               +N                                        LLE + ++S IC  
Sbjct: 77  GLKVMN----------------------------------------LLELVDQLSHICL- 95

Query: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
             DYR+ YR++VR    C+E+      +   +N RY ++ L+ +  S+     E LA   
Sbjct: 96  -HDYREVYREHVR----CLEE-----WQEAGVNGRYNQVLLVAKPSSESP---ESLACPF 142

Query: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
               E  +  + +E LFD  ++ S     VV QG+AG GKT LARKM+LDWA+GTLY  R
Sbjct: 143 P---EQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGR 199

Query: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
           FDY+FY+ C+EV L+ +  L  L+  CC D   P+ +I+R+P R+LF++DGFDELQ  F+
Sbjct: 200 FDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFE 259

Query: 313 EHIGPLCTDWQKAERG----DILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHV 368
           E +          +RG    + LL  LIR+  LP  SLLITTRP+AL  L+ LL   RHV
Sbjct: 260 EKL---------KKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHV 310

Query: 369 EILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMES 428
            ILGFSE +R  YF  YF+DE QA  AF ++Q+N++L+  C +P +CW+VC+ L+ QME 
Sbjct: 311 HILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMER 370

Query: 429 GKSLAQTSKTTTAVYVFFLSSLLQP--RGGSQEHGLCAHLWGLCSLAADGIWNQKILFEE 486
           GK + +T + +T +++ ++S+ L P   GG  E      L  LCSLAA+GI +Q+ LFEE
Sbjct: 371 GKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEE 430

Query: 487 SDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNV 546
           ++LR H L    ++AFL  N +Q  +  +KFYSF H++FQ+FF AM YL++E++      
Sbjct: 431 AELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQ------ 484

Query: 547 PGSRL-KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIR 605
             SRL K   R+V  LLE   +     +   ++FL  +  ++  S LE K   +IS  + 
Sbjct: 485 --SRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542

Query: 606 LELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQ 644
            +L  + E     K         +L + LYE + ++ V+
Sbjct: 543 QDLKHFKEQMESMK----HNRTWDLEFSLYEAKIKNLVK 577


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  225 bits (574), Expect = 1e-58
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193

Query: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253

Query: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313

Query: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373

Query: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433

Query: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score =  211 bits (537), Expect = 3e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132

Query: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192

Query: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252

Query: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312

Query: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372

Query: 1001 QNLGLSE 1007
            + L L++
Sbjct: 373  RVLWLAD 379



 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325



 Score =  182 bits (462), Expect = 1e-45
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57

Query: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117

Query: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
             LGD+G+   C  L   S  L+ L + E
Sbjct: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
            L L     +  +   L ++   KP   ELTV
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  225 bits (574), Expect = 1e-58
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193

Query: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253

Query: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313

Query: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373

Query: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433

Query: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score =  211 bits (537), Expect = 3e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132

Query: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192

Query: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252

Query: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312

Query: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372

Query: 1001 QNLGLSE 1007
            + L L++
Sbjct: 373  RVLWLAD 379



 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325



 Score =  182 bits (462), Expect = 1e-45
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57

Query: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117

Query: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
             LGD+G+   C  L   S  L+ L + E
Sbjct: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
            L L     +  +   L ++   KP   ELTV
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  225 bits (574), Expect = 1e-58
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193

Query: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253

Query: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313

Query: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373

Query: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433

Query: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score =  211 bits (537), Expect = 3e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132

Query: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192

Query: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252

Query: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312

Query: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372

Query: 1001 QNLGLSE 1007
            + L L++
Sbjct: 373  RVLWLAD 379



 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325



 Score =  182 bits (462), Expect = 1e-45
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57

Query: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117

Query: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
             LGD+G+   C  L   S  L+ L + E
Sbjct: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
            L L     +  +   L ++   KP   ELTV
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  225 bits (574), Expect = 1e-58
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193

Query: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253

Query: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313

Query: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373

Query: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433

Query: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score =  211 bits (537), Expect = 3e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132

Query: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192

Query: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252

Query: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312

Query: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372

Query: 1001 QNLGLSE 1007
            + L L++
Sbjct: 373  RVLWLAD 379



 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325



 Score =  182 bits (462), Expect = 1e-45
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57

Query: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117

Query: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
             LGD+G+   C  L   S  L+ L + E
Sbjct: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
            L L     +  +   L ++   KP   ELTV
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177


>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  225 bits (574), Expect = 1e-58
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193

Query: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253

Query: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313

Query: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373

Query: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433

Query: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score =  211 bits (537), Expect = 3e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132

Query: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192

Query: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252

Query: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312

Query: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372

Query: 1001 QNLGLSE 1007
            + L L++
Sbjct: 373  RVLWLAD 379



 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325



 Score =  182 bits (462), Expect = 1e-45
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57

Query: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117

Query: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
             LGD+G+   C  L   S  L+ L + E
Sbjct: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
            L L     +  +   L ++   KP   ELTV
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177


>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  225 bits (574), Expect = 1e-58
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193

Query: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253

Query: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313

Query: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373

Query: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433

Query: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score =  211 bits (537), Expect = 3e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132

Query: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192

Query: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252

Query: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312

Query: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372

Query: 1001 QNLGLSE 1007
            + L L++
Sbjct: 373  RVLWLAD 379



 Score =  208 bits (529), Expect = 2e-53
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99

Query: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159

Query: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219

Query: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279

Query: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325



 Score =  182 bits (462), Expect = 1e-45
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57

Query: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117

Query: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
             LGD+G+   C  L   S  L+ L + E
Sbjct: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265



 Score = 94.0 bits (232), Expect = 7e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86

Query: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146

Query: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
            L L     +  +   L ++   KP   ELTV
Sbjct: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,867,432
Number of Sequences: 37866
Number of extensions: 1801818
Number of successful extensions: 5894
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 5149
Number of HSP's gapped (non-prelim): 323
length of query: 1036
length of database: 18,247,518
effective HSP length: 112
effective length of query: 924
effective length of database: 14,006,526
effective search space: 12942030024
effective search space used: 12942030024
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.