Guide to the Human Genome
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Search of human proteins with 34452684

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34452684 ring finger protein, LIM domain interacting [Homo
sapiens]
         (624 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34452686 ring finger protein, LIM domain interacting [Homo sa...  1230   0.0  
gi|34452684 ring finger protein, LIM domain interacting [Homo sa...  1230   0.0  
gi|5174653 ring finger protein 6 [Homo sapiens]                       427   e-119
gi|34305295 ring finger protein 6 [Homo sapiens]                      427   e-119
gi|34305293 ring finger protein 6 [Homo sapiens]                      427   e-119
gi|34577087 ring finger protein 13 [Homo sapiens]                      79   1e-14
gi|6005864 ring finger protein 13 [Homo sapiens]                       79   1e-14
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    79   2e-14
gi|14149702 ring finger protein 167 [Homo sapiens]                     77   4e-14
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        74   4e-13
gi|37577185 ring finger protein 38 isoform 2 [Homo sapiens]            74   5e-13
gi|37577181 ring finger protein 38 isoform 2 [Homo sapiens]            74   5e-13
gi|37577179 ring finger protein 38 isoform 3 [Homo sapiens]            74   5e-13
gi|37577177 ring finger protein 38 isoform 2 [Homo sapiens]            74   5e-13
gi|37577175 ring finger protein 38 isoform 1 [Homo sapiens]            74   5e-13
gi|7662486 ring finger protein 44 [Homo sapiens]                       73   9e-13
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]         72   2e-12
gi|161016767 mucin 21 [Homo sapiens]                                   65   1e-10
gi|57864582 hornerin [Homo sapiens]                                    65   2e-10
gi|33356174 pinin, desmosome associated protein [Homo sapiens]         65   2e-10
gi|150170725 zinc and ring finger 4 [Homo sapiens]                     64   3e-10
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]           64   4e-10
gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]           64   4e-10
gi|60097902 filaggrin [Homo sapiens]                                   63   9e-10
gi|29788758 ring finger protein 130 [Homo sapiens]                     63   9e-10
gi|150378447 zinc and ring finger 3 [Homo sapiens]                     62   1e-09
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     61   3e-09
gi|37595553 ring finger protein 111 [Homo sapiens]                     61   3e-09
gi|58331204 ring finger protein 150 [Homo sapiens]                     61   4e-09
gi|56711322 ring finger protein 43 [Homo sapiens]                      60   5e-09

>gi|34452686 ring finger protein, LIM domain interacting [Homo
           sapiens]
          Length = 624

 Score = 1230 bits (3182), Expect = 0.0
 Identities = 624/624 (100%), Positives = 624/624 (100%)

Query: 1   MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEST 60
           MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEST
Sbjct: 1   MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEST 60

Query: 61  EEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQ 120
           EEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQ
Sbjct: 61  EEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQ 120

Query: 121 SWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPR 180
           SWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPR
Sbjct: 121 SWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPR 180

Query: 181 SESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPR 240
           SESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPR
Sbjct: 181 SESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPR 240

Query: 241 RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS 300
           RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS
Sbjct: 241 RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS 300

Query: 301 SDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESER 360
           SDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESER
Sbjct: 301 SDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESER 360

Query: 361 GGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFM 420
           GGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFM
Sbjct: 361 GGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFM 420

Query: 421 YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSS 480
           YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSS
Sbjct: 421 YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSS 480

Query: 481 SGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNED 540
           SGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNED
Sbjct: 481 SGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNED 540

Query: 541 DDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600
           DDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRW
Sbjct: 541 DDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600

Query: 601 LSENSTCPICRRAVLASGNRESVV 624
           LSENSTCPICRRAVLASGNRESVV
Sbjct: 601 LSENSTCPICRRAVLASGNRESVV 624


>gi|34452684 ring finger protein, LIM domain interacting [Homo
           sapiens]
          Length = 624

 Score = 1230 bits (3182), Expect = 0.0
 Identities = 624/624 (100%), Positives = 624/624 (100%)

Query: 1   MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEST 60
           MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEST
Sbjct: 1   MENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGEST 60

Query: 61  EEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQ 120
           EEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQ
Sbjct: 61  EEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQ 120

Query: 121 SWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPR 180
           SWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPR
Sbjct: 121 SWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPR 180

Query: 181 SESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPR 240
           SESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPR
Sbjct: 181 SESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPR 240

Query: 241 RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS 300
           RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS
Sbjct: 241 RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS 300

Query: 301 SDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESER 360
           SDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESER
Sbjct: 301 SDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESER 360

Query: 361 GGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFM 420
           GGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFM
Sbjct: 361 GGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFM 420

Query: 421 YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSS 480
           YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSS
Sbjct: 421 YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSS 480

Query: 481 SGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNED 540
           SGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNED
Sbjct: 481 SGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNED 540

Query: 541 DDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600
           DDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRW
Sbjct: 541 DDDQPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600

Query: 601 LSENSTCPICRRAVLASGNRESVV 624
           LSENSTCPICRRAVLASGNRESVV
Sbjct: 601 LSENSTCPICRRAVLASGNRESVV 624


>gi|5174653 ring finger protein 6 [Homo sapiens]
          Length = 685

 Score =  427 bits (1097), Expect = e-119
 Identities = 286/704 (40%), Positives = 372/704 (52%), Gaps = 112/704 (15%)

Query: 1   MENSDSNDKGSGDQSAAQ--------RRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNL 52
           M  S S   G  +++  Q        RR Q +RL REEA+YQF+N L++EDYRLMRD+NL
Sbjct: 1   MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNL 60

Query: 53  LGTPGESTEEELLRRLQQIKEG----PPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQT 108
           LGTPGE T EEL +RL  +KE     P  ++    R  +   + S+ DS+++WLN+ R+T
Sbjct: 61  LGTPGEITSEELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRT 120

Query: 109 GNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVN----------------------RN 146
           GN TRSGQ GNQ+WRAVSRTNPN+G+FRFSLEI+VN                      R+
Sbjct: 121 GNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRD 180

Query: 147 NGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTS--------------------- 185
           + +   +    P ARR+  +   N +      PR+   S                     
Sbjct: 181 HTANRQQRSTSPVARRTRSQTSVNFNGSSSNIPRTRLASRGQNPAEGSFSTLGRLRNGIG 240

Query: 186 ----------ARPSRSERNSTEALTEVPPTRGQRRARSRSPDH--------RRTRARAE- 226
                     +R + S   +    +E+    GQR   +   ++        R T  R E 
Sbjct: 241 GAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEP 300

Query: 227 ---RSRSPLHPMSEIPRRS---HHSISSQTFEHPLVNETEGSSRTRHHVTL-RQQISGPE 279
              RS S     S I R+S   +H+  SQ    P+   T  S R R    +  +Q    E
Sbjct: 301 IRLRSTSNSRSRSPIQRQSGTVYHN--SQRESRPVQQTTRRSVRRRGRTRVFLEQDRERE 358

Query: 280 LLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSI 339
                    S +R  S+        +S  ST   +R PTI LDLQVRR+RPGE R RDSI
Sbjct: 359 RRGTAYTPFSNSRLVSRITVEEGEESSRSSTAV-RRHPTITLDLQVRRIRPGENRDRDSI 417

Query: 340 ASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTS 399
           A+RTRSR     NTVT ES  GGFRRT SR ER+G+RTYVSTI +P+RRI    L E +S
Sbjct: 418 ANRTRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSS 477

Query: 400 VAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSS 459
           VA++++LRQIMTGFGELS  M +DS+SE       RN +                  S  
Sbjct: 478 VALRSILRQIMTGFGELSSLMEADSESE-----LQRNGQHLPDMH------------SEL 520

Query: 460 SSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRH-RAPV 518
           S+  + ++ S     SS    + G+S+E       G NE +     +   R GR  R P 
Sbjct: 521 SNLGTDNNRSQHREGSSQDRQAQGDSTE-----MHGENETTQPHTRNSDSRGGRQLRNPN 575

Query: 519 TFDESGSLPFLSLAQFFLLNE-DDDDQPRGLTKEQIDNLAMRSFGEN----DALKTCSVC 573
              E+G+LP L LA FFLLNE DDDD+ RGLTKEQIDNL+ R +  N    +  K CSVC
Sbjct: 576 NLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVC 635

Query: 574 ITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLAS 617
           I++Y  GNKLR+LPC HE+H+HCIDRWLSEN TCPICR+ VL S
Sbjct: 636 ISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGS 679


>gi|34305295 ring finger protein 6 [Homo sapiens]
          Length = 685

 Score =  427 bits (1097), Expect = e-119
 Identities = 286/704 (40%), Positives = 372/704 (52%), Gaps = 112/704 (15%)

Query: 1   MENSDSNDKGSGDQSAAQ--------RRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNL 52
           M  S S   G  +++  Q        RR Q +RL REEA+YQF+N L++EDYRLMRD+NL
Sbjct: 1   MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNL 60

Query: 53  LGTPGESTEEELLRRLQQIKEG----PPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQT 108
           LGTPGE T EEL +RL  +KE     P  ++    R  +   + S+ DS+++WLN+ R+T
Sbjct: 61  LGTPGEITSEELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRT 120

Query: 109 GNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVN----------------------RN 146
           GN TRSGQ GNQ+WRAVSRTNPN+G+FRFSLEI+VN                      R+
Sbjct: 121 GNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRD 180

Query: 147 NGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTS--------------------- 185
           + +   +    P ARR+  +   N +      PR+   S                     
Sbjct: 181 HTANRQQRSTSPVARRTRSQTSVNFNGSSSNIPRTRLASRGQNPAEGSFSTLGRLRNGIG 240

Query: 186 ----------ARPSRSERNSTEALTEVPPTRGQRRARSRSPDH--------RRTRARAE- 226
                     +R + S   +    +E+    GQR   +   ++        R T  R E 
Sbjct: 241 GAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEP 300

Query: 227 ---RSRSPLHPMSEIPRRS---HHSISSQTFEHPLVNETEGSSRTRHHVTL-RQQISGPE 279
              RS S     S I R+S   +H+  SQ    P+   T  S R R    +  +Q    E
Sbjct: 301 IRLRSTSNSRSRSPIQRQSGTVYHN--SQRESRPVQQTTRRSVRRRGRTRVFLEQDRERE 358

Query: 280 LLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSI 339
                    S +R  S+        +S  ST   +R PTI LDLQVRR+RPGE R RDSI
Sbjct: 359 RRGTAYTPFSNSRLVSRITVEEGEESSRSSTAV-RRHPTITLDLQVRRIRPGENRDRDSI 417

Query: 340 ASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTS 399
           A+RTRSR     NTVT ES  GGFRRT SR ER+G+RTYVSTI +P+RRI    L E +S
Sbjct: 418 ANRTRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSS 477

Query: 400 VAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSS 459
           VA++++LRQIMTGFGELS  M +DS+SE       RN +                  S  
Sbjct: 478 VALRSILRQIMTGFGELSSLMEADSESE-----LQRNGQHLPDMH------------SEL 520

Query: 460 SSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRH-RAPV 518
           S+  + ++ S     SS    + G+S+E       G NE +     +   R GR  R P 
Sbjct: 521 SNLGTDNNRSQHREGSSQDRQAQGDSTE-----MHGENETTQPHTRNSDSRGGRQLRNPN 575

Query: 519 TFDESGSLPFLSLAQFFLLNE-DDDDQPRGLTKEQIDNLAMRSFGEN----DALKTCSVC 573
              E+G+LP L LA FFLLNE DDDD+ RGLTKEQIDNL+ R +  N    +  K CSVC
Sbjct: 576 NLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVC 635

Query: 574 ITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLAS 617
           I++Y  GNKLR+LPC HE+H+HCIDRWLSEN TCPICR+ VL S
Sbjct: 636 ISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGS 679


>gi|34305293 ring finger protein 6 [Homo sapiens]
          Length = 685

 Score =  427 bits (1097), Expect = e-119
 Identities = 286/704 (40%), Positives = 372/704 (52%), Gaps = 112/704 (15%)

Query: 1   MENSDSNDKGSGDQSAAQ--------RRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNL 52
           M  S S   G  +++  Q        RR Q +RL REEA+YQF+N L++EDYRLMRD+NL
Sbjct: 1   MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNL 60

Query: 53  LGTPGESTEEELLRRLQQIKEG----PPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQT 108
           LGTPGE T EEL +RL  +KE     P  ++    R  +   + S+ DS+++WLN+ R+T
Sbjct: 61  LGTPGEITSEELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRT 120

Query: 109 GNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVN----------------------RN 146
           GN TRSGQ GNQ+WRAVSRTNPN+G+FRFSLEI+VN                      R+
Sbjct: 121 GNATRSGQNGNQTWRAVSRTNPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRD 180

Query: 147 NGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTS--------------------- 185
           + +   +    P ARR+  +   N +      PR+   S                     
Sbjct: 181 HTANRQQRSTSPVARRTRSQTSVNFNGSSSNIPRTRLASRGQNPAEGSFSTLGRLRNGIG 240

Query: 186 ----------ARPSRSERNSTEALTEVPPTRGQRRARSRSPDH--------RRTRARAE- 226
                     +R + S   +    +E+    GQR   +   ++        R T  R E 
Sbjct: 241 GAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHVWENGARSNVTVRNTNQRLEP 300

Query: 227 ---RSRSPLHPMSEIPRRS---HHSISSQTFEHPLVNETEGSSRTRHHVTL-RQQISGPE 279
              RS S     S I R+S   +H+  SQ    P+   T  S R R    +  +Q    E
Sbjct: 301 IRLRSTSNSRSRSPIQRQSGTVYHN--SQRESRPVQQTTRRSVRRRGRTRVFLEQDRERE 358

Query: 280 LLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSI 339
                    S +R  S+        +S  ST   +R PTI LDLQVRR+RPGE R RDSI
Sbjct: 359 RRGTAYTPFSNSRLVSRITVEEGEESSRSSTAV-RRHPTITLDLQVRRIRPGENRDRDSI 417

Query: 340 ASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTS 399
           A+RTRSR     NTVT ES  GGFRRT SR ER+G+RTYVSTI +P+RRI    L E +S
Sbjct: 418 ANRTRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSS 477

Query: 400 VAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSS 459
           VA++++LRQIMTGFGELS  M +DS+SE       RN +                  S  
Sbjct: 478 VALRSILRQIMTGFGELSSLMEADSESE-----LQRNGQHLPDMH------------SEL 520

Query: 460 SSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRH-RAPV 518
           S+  + ++ S     SS    + G+S+E       G NE +     +   R GR  R P 
Sbjct: 521 SNLGTDNNRSQHREGSSQDRQAQGDSTE-----MHGENETTQPHTRNSDSRGGRQLRNPN 575

Query: 519 TFDESGSLPFLSLAQFFLLNE-DDDDQPRGLTKEQIDNLAMRSFGEN----DALKTCSVC 573
              E+G+LP L LA FFLLNE DDDD+ RGLTKEQIDNL+ R +  N    +  K CSVC
Sbjct: 576 NLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGKICSVC 635

Query: 574 ITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLAS 617
           I++Y  GNKLR+LPC HE+H+HCIDRWLSEN TCPICR+ VL S
Sbjct: 636 ISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGS 679


>gi|34577087 ring finger protein 13 [Homo sapiens]
          Length = 381

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 36/94 (38%), Positives = 56/94 (59%), Gaps = 5/94 (5%)

Query: 529 LSLAQFFLLNEDDDDQPRG----LTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLR 584
           L L   F++ +   D+ R     L K+Q+  L +  F + D    C++C+ EY +G+KLR
Sbjct: 195 LILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLR 254

Query: 585 KLPCSHEYHVHCIDRWLSE-NSTCPICRRAVLAS 617
            LPCSH YH  C+D WL++   TCP+C++ V+ S
Sbjct: 255 ILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPS 288


>gi|6005864 ring finger protein 13 [Homo sapiens]
          Length = 381

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 36/94 (38%), Positives = 56/94 (59%), Gaps = 5/94 (5%)

Query: 529 LSLAQFFLLNEDDDDQPRG----LTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLR 584
           L L   F++ +   D+ R     L K+Q+  L +  F + D    C++C+ EY +G+KLR
Sbjct: 195 LILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLR 254

Query: 585 KLPCSHEYHVHCIDRWLSE-NSTCPICRRAVLAS 617
            LPCSH YH  C+D WL++   TCP+C++ V+ S
Sbjct: 255 ILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPS 288


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 109/511 (21%), Positives = 194/511 (37%), Gaps = 32/511 (6%)

Query: 2    ENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTE 61
            E+SDS+D    D S +   S  +  D + +     N+    D     D++       S++
Sbjct: 700  ESSDSSDSSDSDSSDSSDSSNSNSSDSDSS-----NSSDSSDSSNSSDSSDSSDSSNSSD 754

Query: 62   EELLRRLQQIKEGPPPQNSDENRGGDSSD--DVSNGDSIIDWLNSVRQTGNTTRSGQRGN 119
                             +SD +   DSSD  D SN     D  NS   + +++ S    N
Sbjct: 755  SS--------DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS-SDSSDSSNSSDSSN 805

Query: 120  QSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPS----ARRSSGENVENNSQRQ 175
             S  + S  + +S     S   N + ++ S NS + ++ S       S   N  ++S   
Sbjct: 806  SSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSS 865

Query: 176  VENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPM 235
              +  S+S+++  S    +S E+      +     + S S D   +   ++ S S     
Sbjct: 866  DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNS--SDS 923

Query: 236  SEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNAS 295
            SE    S +S SS +      +++  SS +          +  +        +S + N+S
Sbjct: 924  SESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSS 983

Query: 296  QGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVT 355
              + SSD++ S +S+ S     +                   S +S + + S + N++ +
Sbjct: 984  DSSDSSDSSDSSDSSDSSNSSDS----------SDSSDSSDSSNSSDSSNSSDSSNSSDS 1033

Query: 356  YESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGE 415
             +S         S S  +   +  S          ++  S+++  +  +           
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS 1093

Query: 416  LSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSS 475
                  SDS      S S+ + + ++S +    S    SS SS SS+SS SS SS SS S
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDS 1153

Query: 476  SPSSSSGGESSETSSDLFEGSNEGSSSSGSS 506
            S SS S   S  + S     S++ S+SS SS
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1184



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 113/523 (21%), Positives = 190/523 (36%), Gaps = 10/523 (1%)

Query: 3    NSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTEE 62
            +SDS+D    D S +   S  D  D + +     ++    +     D++      +S++ 
Sbjct: 560  SSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDS 619

Query: 63   ELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSW 122
               +      E     +SD +   DSSD  S+  S     +    + N++ S    + S 
Sbjct: 620  SDSKSDSSKSES---DSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSD 676

Query: 123  RAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSE 182
             + S  + NS D   S + + N +  S +S++ +  S+  S   N  N+S     N    
Sbjct: 677  SSSSSDSSNSSDSSDSSD-SSNSSESSDSSDSSDSDSSDSSDSSN-SNSSDSDSSNSSDS 734

Query: 183  STSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRS 242
            S S+  S S  +S  + +            S S D   +   ++ S S     S+    S
Sbjct: 735  SDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNS-----SDSNDSS 789

Query: 243  HHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSD 302
            + S SS +      + +  SS +          S     S     +S + ++S  + SSD
Sbjct: 790  NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSD 849

Query: 303  TAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGG 362
             + S  S  S     +   D              DS  S   S S   +N+   +S    
Sbjct: 850  GSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSS 909

Query: 363  FRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYS 422
                 S S  +   +  S          ++  S+++  +  +            +    S
Sbjct: 910  NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969

Query: 423  DSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSG 482
            DS+S  +   SN +     S S        SS+ S SS SS SS SS+SS SS+ S SS 
Sbjct: 970  DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSN 1029

Query: 483  GESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGS 525
               S  SSD  + S+   SS  S  +       +  + D S S
Sbjct: 1030 SSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1072



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 100/456 (21%), Positives = 178/456 (39%), Gaps = 77/456 (16%)

Query: 73  EGPPPQNSDENRGGDSSDDVSNGDSIIDW---LNSVRQTGNTTRSGQRGNQSWRAVSRTN 129
           +G  P +SDE+ G D ++  S+ +S        NS     N   S  +G +   + S ++
Sbjct: 461 QGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSD 520

Query: 130 PNSGDFRFSLEINVNRNNGSQNSE-------------------NENEPSARRSSGENVEN 170
            N+ D       N N NNG+ +++                   + +  S+  S  ++ ++
Sbjct: 521 TNNSDS------NGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDS 574

Query: 171 NSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRS 230
           NS    ++  S+S+ +  S S  +S  + +            S S D +   +++E   S
Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634

Query: 231 PLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASG 290
                S+    S  S SS + ++   +++  SS +          S     S    ++S 
Sbjct: 635 DSDSKSD----SSDSNSSDSSDNSDSSDSSNSSNSSD--------SSDSSDSSDSSSSSD 682

Query: 291 TRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTP 350
           + N+S  + SSD++ S ES+ S     +   D              DS +S +   S + 
Sbjct: 683 SSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS----DSSNSNSSDSDSSNSSDSSDSS 738

Query: 351 NNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIM 410
           N++ + +S         S S  +                 N+  S  +S +  +      
Sbjct: 739 NSSDSSDSSDSSNSSDSSDSSDSS----------------NSSDSSDSSDSSDS------ 776

Query: 411 TGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSS 470
                      SDS +    + S+ + + ++S +    S    SS SS SS S SS+SS 
Sbjct: 777 -----------SDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSD 825

Query: 471 SSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSS 506
           SS+SS  S SS    S  SSD  +GS+  SS+   S
Sbjct: 826 SSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 98/450 (21%), Positives = 184/450 (40%), Gaps = 20/450 (4%)

Query: 73  EGPPPQNSDENRGGDS---SDDVSNGDSIIDWLNSVRQTGNTTRSGQ-RGNQSWRAVSRT 128
           EGP  ++   N+ G S   SD  S+G    D+ +   Q  +   S +  GN    + S  
Sbjct: 424 EGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDN 483

Query: 129 NPNS-GDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSAR 187
           N +S GD  ++ + + +  NGS +   E++ S   S   N ++N      N  ++ + + 
Sbjct: 484 NSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSG 543

Query: 188 PSRSERNSTEALTEVPPTRGQRRARSRSPD-HRRTRARAERSRSPLHPMSEIPRRSHHSI 246
             +S+ + +++      +     + S S D +  + + +  S S     S+    S+ S 
Sbjct: 544 KGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSD 603

Query: 247 SSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAAS 306
           SS + +    +++  SS ++   + + +    +  S+   + S + ++S  + SSD++ S
Sbjct: 604 SSDSSDSSDSSDSSDSSDSKSD-SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNS 662

Query: 307 GESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRT 366
             S+ S     +   D              DS  S   S S   +++   +S        
Sbjct: 663 SNSSDSSDSSDS--SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSN 720

Query: 367 FSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDS 426
            + S+     +  S+         ++  S  +S +  +      +   + S    SDS  
Sbjct: 721 SNSSDSDSSNSSDSS---------DSSNSSDSSDSSDSSNSSDSSDSSDSS--NSSDSSD 769

Query: 427 EPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESS 486
               S S+ +   ++S      S    SS SS SS+SS SS SS SS S  S+SS   +S
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829

Query: 487 ETSSDLFEGSNEGSSSSGSSGARREGRHRA 516
             SSD    S+   SS  S G+  +  +R+
Sbjct: 830 SDSSDSSNSSDSSDSSDSSDGSDSDSSNRS 859



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 102/506 (20%), Positives = 188/506 (37%), Gaps = 28/506 (5%)

Query: 3    NSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTEE 62
            ++ S+   S D S +   S  D  +  ++     N+    D     D++      + ++ 
Sbjct: 798  SNSSDSSNSSDSSDSSDSSDSDSSNSSDSS----NSSDSSDSSNSSDSSDSSDSSDGSDS 853

Query: 63   ELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSW 122
            +   R           +SD +   DSSD   + +S     +S     + + S    N S 
Sbjct: 854  DSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSS- 912

Query: 123  RAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSE 182
               S  + NS D   S   + N N+   ++ +++  S+  S+  +  N+S     +  S+
Sbjct: 913  --DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970

Query: 183  STSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSP-LHPMSEIPRR 241
            S S+  S S  +S  + +            S S D   +   ++ S S      S+    
Sbjct: 971  SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030

Query: 242  SHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSS 301
            S  S SS + +    +++  SS + +           +  S     +S + ++S+ + SS
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD--SSDSSDSSDSSDSSESSDSS 1088

Query: 302  DTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERG 361
            D++ S +S+ S     +                   S +S +   S + N++ + +S   
Sbjct: 1089 DSSNSSDSSDSSDSSDS----------------SDSSDSSDSSDSSDSSNSSDSSDSSDS 1132

Query: 362  GFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMY 421
                  S S  +   +  S          ++  S+++  +  +                 
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1192

Query: 422  SDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
            SDS      S S+ + + ++S      S   SS  S SS S+ SS SS SS SS  S+SS
Sbjct: 1193 SDSSDSSDSSDSSDSSDSSDSSDSSDSSD--SSDSSDSSDSNESSDSSDSSDSSDSSNSS 1250

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSG 507
                S  SSD    SN+ S S   SG
Sbjct: 1251 DSSDSSDSSDSTSDSNDESDSQSKSG 1276



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 37/119 (31%), Positives = 54/119 (45%), Gaps = 15/119 (12%)

Query: 422 SDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSS---------------SSSSS 466
           ++SDS   G+  N + ++++S  G+  S    SS SS+SS               SS S 
Sbjct: 522 NNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSD 581

Query: 467 SSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGS 525
           SS S SS SS S SS   +S  SSD  + S+   SS  S       +  +  +  +S S
Sbjct: 582 SSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 90/474 (18%), Positives = 175/474 (36%), Gaps = 16/474 (3%)

Query: 2    ENSDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTE 61
            ++SDS+D   G  S +  RS               N+    D     D+N      +S++
Sbjct: 840  DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSD---SSDSNESSNSSDSSD 896

Query: 62   EELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQS 121
                             +SD +   DSS+  ++ D+     ++   + N++ S    + S
Sbjct: 897  SSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDN-----SNSSDSSNSSDSSDSSDSS 951

Query: 122  WRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRS 181
              + S  + +S +   S + N + ++ S NS + ++ S    S ++ ++++     +   
Sbjct: 952  NSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1011

Query: 182  ESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERS-RSPLHPMSEIPR 240
             S S+  S S  +S  + +            S S D   +   +  S  S     S+   
Sbjct: 1012 SSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1071

Query: 241  RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS 300
             S  S SS + E    +++  SS +             +  S     +S + N+S  + S
Sbjct: 1072 SSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSD--SSDSSDSSDSSNSSDSSDS 1129

Query: 301  SDTAASGE-STGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESE 359
            SD++ S + S  S     +   D              DS  S   S S   +++      
Sbjct: 1130 SDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1189

Query: 360  RGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYF 419
                  + S        +  S+         ++  S  +S + ++      +   + S  
Sbjct: 1190 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNS 1249

Query: 420  MYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSS 473
              S   S+ + S S+ N E ++S+S    SG G+++GS S S S  S S+ S+S
Sbjct: 1250 SDSSDSSDSSDSTSDSNDE-SDSQSK---SGNGNNNGSDSDSDSEGSDSNHSTS 1299



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 7/103 (6%)

Query: 423 DSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSG 482
           D DS+ T   +N +       +G G +G   +  S S    S SS S SS SS+ S SS 
Sbjct: 512 DDDSDSTSDTNNSDS------NGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSD 565

Query: 483 GESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGS 525
              S+ SSD    S+  SS S SS +       +  + D S S
Sbjct: 566 SSDSD-SSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 21/90 (23%)

Query: 436 NMERAESRSGRGGSGGGSSSGSSS--------------------SSSSSSSSSSSSSSSS 475
           N+E    +S  G   G S++GS S                    +SS  S+ +  ++S S
Sbjct: 422 NIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSES 481

Query: 476 SPSSSSGGESSETSSDLFEGSNEGSSSSGS 505
             +SSS G++S  S +  +  N GS S G+
Sbjct: 482 DNNSSSRGDASYNSDESKDNGN-GSDSKGA 510


>gi|14149702 ring finger protein 167 [Homo sapiens]
          Length = 350

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 31/72 (43%), Positives = 46/72 (63%), Gaps = 1/72 (1%)

Query: 544 QPRGLTKEQIDNLAMRSFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSE 603
           Q   LTKEQ+  +    + + D    C++C+ EY +G+KLR LPC+H YH  C+D WL++
Sbjct: 204 QRNRLTKEQLKQIPTHDYQKGDQYDVCAICLDEYEDGDKLRVLPCAHAYHSRCVDPWLTQ 263

Query: 604 -NSTCPICRRAV 614
              TCPIC++ V
Sbjct: 264 TRKTCPICKQPV 275


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 95/335 (28%), Positives = 141/335 (42%), Gaps = 61/335 (18%)

Query: 210  RARSRSPDHRRTRAR--AERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRH 267
            RARSR+P    +++R  +ER+ SP   M + P +S    +      P+   +  S ++R 
Sbjct: 2404 RARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPV--PSAFSDQSRC 2461

Query: 268  HVTLRQQISGPELLSRGLFA----ASGTRNA-----SQGAGSSDTAASGESTGSGQRPPT 318
             +     ++G + LS G  A    ++G  N      + G   SD      STG+ Q  P+
Sbjct: 2462 LIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQ--PS 2519

Query: 319  IVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTY 378
             +  LQ  + R      R S +S + S S + +++ +  S   G   + S      V+  
Sbjct: 2520 ALAALQPAKER------RSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPE 2573

Query: 379  VSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNME 438
            V+  R+P           + + A +  +R+                  EPT +       
Sbjct: 2574 VALKRVP-----------SPTPAPKEAVRE--------------GRPPEPTPA------- 2601

Query: 439  RAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEG--- 495
                R  R  S   SSS SSSSSSSSSSSSSSSSSSSS SSSS   SS + S    G   
Sbjct: 2602 ---KRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQA 2658

Query: 496  -SNEGSSSSGSSGARREGRHRAPV-TFDESGSLPF 528
                 S      G RR    R P+ +  +S SL +
Sbjct: 2659 LPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSY 2693



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 130/482 (26%), Positives = 176/482 (36%), Gaps = 53/482 (10%)

Query: 72  KEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGN-QSWRAVSRTNP 130
           K  P P +  E     +S + S+G +  D  +S   +    RS      +  R+ SRT  
Sbjct: 442 KPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPT 501

Query: 131 NSGDFRFSLEINVNRNNGSQNSENENEPSARRSS------GENVENNSQRQVENPRSEST 184
             G  R S      R+  +Q       P  R  S      G +   N+QR     R  S 
Sbjct: 502 KRGHSR-SRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQR-----RGRSR 555

Query: 185 SARPSRSERNST----EALTEVPPTRGQ--------RRARSRSPDHRRTRARAERSRSPL 232
           SAR  RS   S      + +  P  RG+        RR+RSR+P  RR+R+R    R   
Sbjct: 556 SARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRS 615

Query: 233 HPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTR 292
              +   RRS           P+   +   S  R     R +       SR       +R
Sbjct: 616 RSRTPARRRSR-------TRSPVRRRSRSRSPARRSGRSRSRTPARRGRSR-------SR 661

Query: 293 NASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTP-- 350
             ++   S     +  S  S  R P      + R  R G  R R S+  R RS S+TP  
Sbjct: 662 TPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSR-SLVRRGRSHSRTPQR 720

Query: 351 NNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTM-LRQI 409
                  SER    RT  R  R+     +   RI  RR  +  LS   S A   + LR+ 
Sbjct: 721 RGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRR--SRSLSSPRSKAKSRLSLRRS 778

Query: 410 MTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSS 469
           ++G    S      S + P  S S  +  +A+SR+    S   SSS      S + S  S
Sbjct: 779 LSG---SSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRS-RSSSSPPPKQKSKTPSRQS 834

Query: 470 SSSSSSSPSSSSG---GESSETSSDLFEGS-NEGSSSSGSSGARREGRHRAPVTFDESGS 525
            SSSS  P   SG    + S TS    E S      S   S    E + R P     SGS
Sbjct: 835 HSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGS 894

Query: 526 LP 527
            P
Sbjct: 895 SP 896



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 77/297 (25%), Positives = 113/297 (38%), Gaps = 57/297 (19%)

Query: 111  TTRSGQRGNQSWRAVSRTNPNSGDFRFSLEIN----VNRNNGSQNSENENE----PSARR 162
            T R G R +   +  SRT P     R S E+     ++R + S +S  E      P  RR
Sbjct: 1667 TARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRR 1726

Query: 163  SSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTR 222
            S   +    +++   + R  S S+   R++  S    +  P  RG +R+RSRS       
Sbjct: 1727 SPSVSSPEPAEKSRSSRRRRSASS--PRTKTTSRRGRSPSPKPRGLQRSRSRS------- 1777

Query: 223  ARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLS 282
             R E++R+         RR   S SSQ+      +     SR+R  VT R++        
Sbjct: 1778 -RREKTRT--------TRRRDRSGSSQS-----TSRRRQRSRSRSRVTRRRR-------- 1815

Query: 283  RGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVR-----------RVRPG 331
                  SG  + S     S   +S    G  + PPT     + R           R  P 
Sbjct: 1816 ----GGSGYHSRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPA 1871

Query: 332  EYRQ---RDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIP 385
             +R+   R  + SR RSRS+T   +      R    R  SRS  + V    S  R P
Sbjct: 1872 THRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTP 1928



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 106/424 (25%), Positives = 154/424 (36%), Gaps = 87/424 (20%)

Query: 102  LNSVRQTGNTTRSGQRGNQSWRAVSRT----NPNSGDFRFSLEINVNRNNGSQN-SENEN 156
            LN+   T    RSG   +   + V+RT       SG    S E++V  +   Q  SE+++
Sbjct: 1505 LNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGS---SQELDVKPSASPQERSESDS 1561

Query: 157  EPSARRSSGENVENNSQRQVENPRSESTSA-RPSRSERNSTEALTEVPPTRGQRRARSRS 215
             P ++  +   +   S R   +P  +S S   P RS   S+  + + P  R   RA+S S
Sbjct: 1562 SPDSKAKTRTPLRQRS-RSGSSPEVDSKSRLSPRRSRSGSSPEVKDKP--RAAPRAQSGS 1618

Query: 216  PDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQI 275
                  +A A R+         +PRRS    SS+    P     EGSS T          
Sbjct: 1619 DSSPEPKAPAPRA---------LPRRSRSGSSSKG-RGP---SPEGSSSTE--------- 1656

Query: 276  SGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQ 335
            S PE   +   A  G+R++ +    S T     S+ S             R+ R    R+
Sbjct: 1657 SSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPE--------LTRKARLS--RR 1706

Query: 336  RDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLS 395
              S +S   +RS+TP       S         SRS R              RR  ++  +
Sbjct: 1707 SRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRR-------------RRSASSPRT 1753

Query: 396  ETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSS 455
            +TTS   ++                          S   R ++R+ SRS R  +      
Sbjct: 1754 KTTSRRGRSP-------------------------SPKPRGLQRSRSRSRREKTRTTRRR 1788

Query: 456  GSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHR 515
              S SS S+S     S S S  +    G S   S      S     SS +S  RR GR R
Sbjct: 1789 DRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSR-----SPARQESSRTSSRRRRGRSR 1843

Query: 516  APVT 519
             P T
Sbjct: 1844 TPPT 1847



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 84/386 (21%), Positives = 135/386 (34%), Gaps = 34/386 (8%)

Query: 141  INVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPR---------SESTSARPSRS 191
            ++  R+    + E +++P A   +    +++ + +   PR         S S    PS  
Sbjct: 1591 LSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPE 1650

Query: 192  ERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTF 251
              +STE+  E PP     R  SRS    +T++R    R       E+ R++  S  S++ 
Sbjct: 1651 GSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSA 1710

Query: 252  EHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTG 311
                 +  E  SRT         +S PE   +    +S  R ++    +  T+  G S  
Sbjct: 1711 S----SSPETRSRTPPRHRRSPSVSSPEPAEKS--RSSRRRRSASSPRTKTTSRRGRSPS 1764

Query: 312  SGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSE 371
               R       LQ  R R    R+  +  +R R RS +  +T +   +R   R   +R  
Sbjct: 1765 PKPR------GLQRSRSRS---RREKTRTTRRRDRSGSSQST-SRRRQRSRSRSRVTRRR 1814

Query: 372  RAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGS 431
            R G   +    R P R+  +   S       +T            S   +  S S  + +
Sbjct: 1815 RGGSGYH---SRSPARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPA 1871

Query: 432  VSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSD 491
               R+  R    S R      S      S S +S +   S S +SP S     S      
Sbjct: 1872 THRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPP-- 1929

Query: 492  LFEGSNEGSSSSGSSGARREGRHRAP 517
                     S S +   RR  R R P
Sbjct: 1930 ----VTRRRSRSRTPTTRRRSRSRTP 1951



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 81/366 (22%), Positives = 134/366 (36%), Gaps = 55/366 (15%)

Query: 157 EPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSP 216
           E S+ RS     +   +++    RSES+S R  R + +  +       ++ +R+ RS +P
Sbjct: 176 ESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESK-KRKHRSPTP 234

Query: 217 DHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEG-SSRTRHHVTLRQQI 275
             +R     +R RS     +   RR+H S S+ +      + +   S+  + H T     
Sbjct: 235 KSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTT----- 289

Query: 276 SGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQ 335
               L  R    ASG R      G  D   S   T S QRP +     + +   P E + 
Sbjct: 290 ---ALAGRSPSPASGRR------GEGDAPFSEPGTTSTQRPSSPETATK-QPSSPYEDKD 339

Query: 336 RDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLS 395
           +D         S +P  + T          T   +ER G            + +  T LS
Sbjct: 340 KDKKEKSATRPSPSPERSSTGPEPPA---PTPLLAERHGGSP---------QPLATTPLS 387

Query: 396 ETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSS 455
           +                       +   S++ PT    +R+  ++  +  +  S   S  
Sbjct: 388 QEP---------------------VNPPSEASPT---RDRSPPKSPEKLPQSSSSESSPP 423

Query: 456 GSSSSSSSSSSSSSSSSSSSSPSSSSGGE--SSETSSDLFEGSNEGSSSSGSSGARREGR 513
               +  S  +SSS  S   +P+  S  E  SS TS +   G  +   S   + +RR GR
Sbjct: 424 SPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGR 483

Query: 514 HRAPVT 519
            R+P T
Sbjct: 484 SRSPAT 489



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 83/382 (21%), Positives = 123/382 (32%), Gaps = 39/382 (10%)

Query: 150  QNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQR 209
            ++ E  N P    S G  +E  +   +    +   S+              E  P+   +
Sbjct: 1313 EHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMK 1372

Query: 210  RARSRSPDHRRTRARAERSRSPLHP--MSEIPRRSHHSISSQTFEHPLVNETEGSSRTRH 267
               +RS  H         S S L P  + +    S+ SISS   +   V  T    R+  
Sbjct: 1373 EQSTRSSGH---------SSSELSPDAVEKAGMSSNQSISSPVLD--AVPRTPSRERSSS 1421

Query: 268  HVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQV-- 325
              +   +   P   SR   + S           S  + SG S G    P T         
Sbjct: 1422 ASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECD 1481

Query: 326  RRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIP 385
                P    Q     SR+ S  +  N  +T + ER G   +  +   A         R P
Sbjct: 1482 SSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVA---------RTP 1532

Query: 386  IRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSG 445
            + +   +G S+   V      ++             S+SDS P      R   R  SRSG
Sbjct: 1533 LGQRSRSGSSQELDVKPSASPQE------------RSESDSSPDSKAKTRTPLRQRSRSG 1580

Query: 446  RGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGS 505
                    S  S   S S SS        ++P + SG +SS         +    S SGS
Sbjct: 1581 SSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGS 1640

Query: 506  SGARREGRHRAPVTFDESGSLP 527
            S    +GR  +P     + S P
Sbjct: 1641 SS---KGRGPSPEGSSSTESSP 1659



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 63/220 (28%), Positives = 88/220 (40%), Gaps = 21/220 (9%)

Query: 298  AGSSDTAASGES--TGSGQRPPTIVLDLQVRRVRPGEYRQ---RDSIASRTRSRSQTPNN 352
            AGS   AA   +  T +   P     +L   RV    Y +   R S     R+RS+TP +
Sbjct: 2353 AGSRTAAALAPASLTSARMAPALSGANLTSPRVPLSAYERVSGRTSPPLLDRARSRTPPS 2412

Query: 353  TVTYESERGGFRRTFSRSERAGVRTYVSTI-------RIPIRRILNTG----LSETTSVA 401
              +    R    R  S S R G     S +       R P+    +      +++TT VA
Sbjct: 2413 APS--QSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVA 2470

Query: 402  IQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSS 461
                L          S   ++   S P   V + ++    + +G       ++   +   
Sbjct: 2471 GSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAALQPAKER 2530

Query: 462  SSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSS 501
             SSSSSSSSSSSSSS SSSS   SS  SS      +EGSS
Sbjct: 2531 RSSSSSSSSSSSSSSSSSSSSSSSSSGSS---SSDSEGSS 2567



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 65/245 (26%), Positives = 93/245 (37%), Gaps = 35/245 (14%)

Query: 123  RAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSE 182
            R+ SRT+P S   R     +V R    + S +   P +RR S       ++R     RS 
Sbjct: 1887 RSRSRTSPVSRR-RSRSRTSVTR----RRSRSRASPVSRRRSRSRTPPVTRR-----RSR 1936

Query: 183  STSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARA-------ERSRSPLHPM 235
            S +    R  R+ T  +T       +RR+RSR+P   R R+R+        RSRS   P 
Sbjct: 1937 SRTPTTRRRSRSRTPPVT-------RRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSP- 1988

Query: 236  SEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNAS 295
              + RR   S +S        + T   +R R        I         L     +R+ S
Sbjct: 1989 --VTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRS 2046

Query: 296  QGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVT 355
              A    + +    T  G+R  T        R  P   R+  S +S  RSRS TP  T  
Sbjct: 2047 PLAIRRRSRSRTPRTARGKRSLT--------RSPPAIRRRSASGSSSDRSRSATPPATRN 2098

Query: 356  YESER 360
            +   R
Sbjct: 2099 HSGSR 2103



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 44/178 (24%), Positives = 67/178 (37%), Gaps = 28/178 (15%)

Query: 69   QQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRT 128
            + ++EG PP+ +   R   SS   S+  S     +S   + +++ S    + S  + S +
Sbjct: 2588 EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647

Query: 129  NPNSGDFRFSLEINVNRNNGSQ-----NSENENEPSARRSSGENVENNS---QRQVENPR 180
            +P+                G Q      S  +  P  RRS       +S    R +    
Sbjct: 2648 SPSPA------------KPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSP 2695

Query: 181  SESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTR-------ARAERSRSP 231
             E     P  S R+   + +E    RGQ R  SRSP H+R R        R   SRSP
Sbjct: 2696 VERRRPSPQPSPRDQQSSSSERGSRRGQ-RGDSRSPSHKRRRETPSPRPMRHRSSRSP 2752



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 31/132 (23%), Positives = 53/132 (40%), Gaps = 3/132 (2%)

Query: 145  RNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPP 204
            R++ S +S + +  S+  SS  +  ++S     +  S S+S+ PS ++           P
Sbjct: 2606 RSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASP 2665

Query: 205  TR---GQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEG 261
             +   G+RR+RS        R     S SP+      P+ S     S + E        G
Sbjct: 2666 KKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRG 2725

Query: 262  SSRTRHHVTLRQ 273
             SR+  H   R+
Sbjct: 2726 DSRSPSHKRRRE 2737



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 24/73 (32%), Positives = 32/73 (43%)

Query: 457  SSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRA 516
            S+ SS  SSS  S  +   +  SS+   SS     +    +   SSS SS   ++G  R 
Sbjct: 1375 STRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRT 1434

Query: 517  PVTFDESGSLPFL 529
            P     SGS P L
Sbjct: 1435 PSRRSRSGSSPGL 1447



 Score = 29.6 bits (65), Expect = 8.7
 Identities = 25/102 (24%), Positives = 42/102 (41%), Gaps = 1/102 (0%)

Query: 428 PTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSE 487
           P     +++ +R  SRS         +  S+S+ S+SSS +S S S S+ + +     + 
Sbjct: 234 PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAG 293

Query: 488 TSSDLFEG-SNEGSSSSGSSGARREGRHRAPVTFDESGSLPF 528
            S     G   EG +     G     R  +P T  +  S P+
Sbjct: 294 RSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPY 335


>gi|37577185 ring finger protein 38 isoform 2 [Homo sapiens]
          Length = 432

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 32/71 (45%), Positives = 42/71 (59%), Gaps = 3/71 (4%)

Query: 544 QPRGLTKEQIDNLAMRSFGENDALKT---CSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600
           +PRGLTK  I+ L    F  N+       C VC+ ++     LR LPC+HE+H  C+D+W
Sbjct: 351 KPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKW 410

Query: 601 LSENSTCPICR 611
           L  N TCPICR
Sbjct: 411 LKANRTCPICR 421


>gi|37577181 ring finger protein 38 isoform 2 [Homo sapiens]
          Length = 432

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 32/71 (45%), Positives = 42/71 (59%), Gaps = 3/71 (4%)

Query: 544 QPRGLTKEQIDNLAMRSFGENDALKT---CSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600
           +PRGLTK  I+ L    F  N+       C VC+ ++     LR LPC+HE+H  C+D+W
Sbjct: 351 KPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKW 410

Query: 601 LSENSTCPICR 611
           L  N TCPICR
Sbjct: 411 LKANRTCPICR 421


>gi|37577179 ring finger protein 38 isoform 3 [Homo sapiens]
          Length = 465

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 32/71 (45%), Positives = 42/71 (59%), Gaps = 3/71 (4%)

Query: 544 QPRGLTKEQIDNLAMRSFGENDALKT---CSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600
           +PRGLTK  I+ L    F  N+       C VC+ ++     LR LPC+HE+H  C+D+W
Sbjct: 384 KPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKW 443

Query: 601 LSENSTCPICR 611
           L  N TCPICR
Sbjct: 444 LKANRTCPICR 454


>gi|37577177 ring finger protein 38 isoform 2 [Homo sapiens]
          Length = 432

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 32/71 (45%), Positives = 42/71 (59%), Gaps = 3/71 (4%)

Query: 544 QPRGLTKEQIDNLAMRSFGENDALKT---CSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600
           +PRGLTK  I+ L    F  N+       C VC+ ++     LR LPC+HE+H  C+D+W
Sbjct: 351 KPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKW 410

Query: 601 LSENSTCPICR 611
           L  N TCPICR
Sbjct: 411 LKANRTCPICR 421


>gi|37577175 ring finger protein 38 isoform 1 [Homo sapiens]
          Length = 515

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 32/71 (45%), Positives = 42/71 (59%), Gaps = 3/71 (4%)

Query: 544 QPRGLTKEQIDNLAMRSFGENDALKT---CSVCITEYTEGNKLRKLPCSHEYHVHCIDRW 600
           +PRGLTK  I+ L    F  N+       C VC+ ++     LR LPC+HE+H  C+D+W
Sbjct: 434 KPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKW 493

Query: 601 LSENSTCPICR 611
           L  N TCPICR
Sbjct: 494 LKANRTCPICR 504


>gi|7662486 ring finger protein 44 [Homo sapiens]
          Length = 432

 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 32/73 (43%), Positives = 42/73 (57%), Gaps = 3/73 (4%)

Query: 542 DDQPRGLTKEQIDNLAMRSFGENDALKT---CSVCITEYTEGNKLRKLPCSHEYHVHCID 598
           D +PRGLTK  I+ L    F  +        C VC +++     LR LPC+HE+H  C+D
Sbjct: 349 DAKPRGLTKADIEQLPSYRFNPDSHQSEQTLCVVCFSDFEARQLLRVLPCNHEFHTKCVD 408

Query: 599 RWLSENSTCPICR 611
           +WL  N TCPICR
Sbjct: 409 KWLKANRTCPICR 421


>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
          Length = 2968

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 45/84 (53%), Positives = 50/84 (59%)

Query: 423  DSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSG 482
            D + +       RN   A SR+    S   SSS SSSSSSSSSSSSSSSSSSSS SSSS 
Sbjct: 2588 DKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2647

Query: 483  GESSETSSDLFEGSNEGSSSSGSS 506
              SS +SS     S+  SSSS SS
Sbjct: 2648 SSSSSSSSSSSSSSSSSSSSSSSS 2671



 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 52/122 (42%), Positives = 61/122 (50%), Gaps = 16/122 (13%)

Query: 422  SDSDSEPTGSVSNRNMERAESRSGRGGSGGG----------------SSSGSSSSSSSSS 465
            S S S  + S S    E    ++G GG G G                SSS SSSSSSSSS
Sbjct: 2568 SSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSS 2627

Query: 466  SSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGS 525
            SSSSSSSSSSS SSSS   SS +SS     S+  SSSS SS +       +  + DE+  
Sbjct: 2628 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAP 2687

Query: 526  LP 527
             P
Sbjct: 2688 AP 2689



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 40/86 (46%), Positives = 52/86 (60%)

Query: 422  SDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
            S + S  + S S+ +   + S S    S   SSS SSSSSSSSSSSSSSSSSSSS SSSS
Sbjct: 2607 SRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2666

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSG 507
               SS T  D    S++ ++ + ++G
Sbjct: 2667 SSSSSTTDEDSSCSSDDEAAPAPTAG 2692



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 40/87 (45%), Positives = 49/87 (56%)

Query: 426  SEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGES 485
            S    S ++ +   + S S    S   SSS SSSSSSSSSSSSSSSSSSSS SSSS   S
Sbjct: 2606 SSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2665

Query: 486  SETSSDLFEGSNEGSSSSGSSGARREG 512
            S +SS   +  +  SS   ++ A   G
Sbjct: 2666 SSSSSSTTDEDSSCSSDDEAAPAPTAG 2692



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 35/87 (40%), Positives = 49/87 (56%)

Query: 422  SDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
            S S S  + S S+ +    E    + G GG  + G + S++SS ++S +SSSSSS SSSS
Sbjct: 2565 SGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSS 2624

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSGA 508
               SS +SS     S+  SSSS SS +
Sbjct: 2625 SSSSSSSSSSSSSSSSSSSSSSSSSSS 2651



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 38/124 (30%), Positives = 56/124 (45%)

Query: 422  SDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
            S   S  + S S+   E      G     GG  +G  + S++SS ++S +SSSSS SSSS
Sbjct: 2564 SSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSS 2623

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGSLPFLSLAQFFLLNEDD 541
               SS +SS     S+  SSSS SS +       +  +   S S    +  +    + DD
Sbjct: 2624 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDD 2683

Query: 542  DDQP 545
            +  P
Sbjct: 2684 EAAP 2687



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 34/94 (36%), Positives = 48/94 (51%)

Query: 422  SDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
            S S S  + S S+ +   + S S    S   SSS SSSSSSSSSSSSSSSSSSS+    S
Sbjct: 2618 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDS 2677

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSGARREGRHR 515
               S + ++          ++  +   ++ G+ R
Sbjct: 2678 SCSSDDEAAPAPTAGPSAQAALPTKATKQAGKAR 2711



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 36/109 (33%), Positives = 50/109 (45%), Gaps = 21/109 (19%)

Query: 421  YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSS------------- 467
            + DS +  +   +    + AE       S  GSSS SSSSSSS S +             
Sbjct: 2535 FEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGG 2594

Query: 468  --------SSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGA 508
                    S++SS ++SP+SSS   SS +SS     S+  SSSS SS +
Sbjct: 2595 CGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 32/86 (37%), Positives = 43/86 (50%)

Query: 423  DSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSG 482
            D   EP   ++  +    +S         G+    SSSSSSS SSSSSSSSSSS S + G
Sbjct: 2524 DLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSSSSSSSSGSETEG 2583

Query: 483  GESSETSSDLFEGSNEGSSSSGSSGA 508
             E  + + D   G+   + S+ SS A
Sbjct: 2584 EEEGDKNGDGGCGTGGRNCSAASSRA 2609



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 25/67 (37%), Positives = 35/67 (52%)

Query: 459  SSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPV 518
            +  S SSSSSSS SSSSS SSSS G  +E   +  +  + G  + G + +    R  +P 
Sbjct: 2554 AEESESSSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAASSRAASPA 2613

Query: 519  TFDESGS 525
            +   S S
Sbjct: 2614 SSSSSSS 2620



 Score = 30.0 bits (66), Expect = 6.7
 Identities = 15/38 (39%), Positives = 21/38 (55%)

Query: 480  SSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAP 517
            S+   S +TS D  EG + G++ S   GA+  GR R P
Sbjct: 2299 SAKRRSRKTSKDTGEGKDGGTAGSEEPGAKARGRGRKP 2336


>gi|161016767 mucin 21 [Homo sapiens]
          Length = 566

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 105/451 (23%), Positives = 169/451 (37%), Gaps = 50/451 (11%)

Query: 102 LNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSEN-----EN 156
           L +   +  T+ S   G+    + + T  NSG    S  ++    +GS  + N      N
Sbjct: 18  LEAATNSNETSTSANTGSSVISSGASTATNSGSSVTSSGVSTATISGSSVTSNGVSIVTN 77

Query: 157 EPSARRSSGENVENNSQRQVENP------RSESTSARPSRSERNSTEALTEVPPTRGQRR 210
                 SSG +   NS+    +        SES++     S   ++E+ T   P+ G   
Sbjct: 78  SEFHTTSSGISTATNSEFSTVSSGISIATNSESSTTSSGASTATNSESST---PSSGAST 134

Query: 211 ARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVT 270
           A +       + A    +       SE    ++   S+ +        +E S+ +    T
Sbjct: 135 ATNSDSSTTSSGASTATNSDSSTTSSEASTATNSESSTTSSGASTATNSESSTVSSRAST 194

Query: 271 LRQQISGPELLSRGLFAASGTRNASQGAGS-----SDTAASGESTGSGQRPPTIVLDLQV 325
                S            S +R  S GAG+     S T +SG ST +     T       
Sbjct: 195 ATNSESSTTSSGASTATNSESRTTSNGAGTATNSESSTTSSGASTATNSESST------- 247

Query: 326 RRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSER--AGVRTYV---- 379
                G     +S +S T S + T  N+ +     G    T S S    +G  T      
Sbjct: 248 --PSSGAGTATNSESSTTSSGAGTATNSESSTVSSGISTVTNSESSTPSSGANTATNSES 305

Query: 380 STIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMER 439
           ST         N+  S T+S A      +  T     S    S+S +  +G+ +  N   
Sbjct: 306 STTSSGANTATNSDSSTTSSGASTATNSESSTTSSGASTATNSESSTTSSGASTATNSGS 365

Query: 440 AESRSGRGGS--------GGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSG------GES 485
           + + SG   +          G+S+ ++S SS++SS +S++++S S + SSG       ES
Sbjct: 366 STTSSGTSTATNSESSTVSSGASTATTSESSTTSSGASTATNSESSTVSSGASTATNSES 425

Query: 486 SETSSDLFEGSNEGSS--SSGSSGARREGRH 514
           S TSS     +N GSS  S+GS  A   G H
Sbjct: 426 STTSSGANTATNSGSSVTSAGSGTAALTGMH 456



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 85/404 (21%), Positives = 151/404 (37%), Gaps = 40/404 (9%)

Query: 92  VSNGDSIIDWLNSVRQT----GNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNN 147
           VS+G SI    NS   T     +T  + +    S  A + TN +S           N ++
Sbjct: 98  VSSGISIAT--NSESSTTSSGASTATNSESSTPSSGASTATNSDSSTTSSGASTATNSDS 155

Query: 148 GSQNSENE---NEPSARRSSGENVENNSQRQVENPR-SESTSARPSRSERNSTEALTEVP 203
            + +SE     N  S+  SSG +   NS+    + R S +T++  S +   ++ A     
Sbjct: 156 STTSSEASTATNSESSTTSSGASTATNSESSTVSSRASTATNSESSTTSSGASTATNSES 215

Query: 204 PTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSS 263
            T       + + +   T + A  + +     SE    S  + ++   E    +   G++
Sbjct: 216 RTTSNGAGTATNSESSTTSSGASTATN-----SESSTPSSGAGTATNSESSTTSSGAGTA 270

Query: 264 RTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDL 323
                 T+   IS     S     +SG   A+     S T +SG +T +     T     
Sbjct: 271 TNSESSTVSSGIS-TVTNSESSTPSSGANTATNS--ESSTTSSGANTATNSDSST----- 322

Query: 324 QVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIR 383
                  G     +S +S T S + T  N+ +  +  G    T S S      T  +T  
Sbjct: 323 ----TSSGASTATNSESSTTSSGASTATNSESSTTSSGASTATNSGSSTTSSGTSTAT-- 376

Query: 384 IPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESR 443
                  N+  S  +S A      +  T     S    S+S +  +G+ +  N E + + 
Sbjct: 377 -------NSESSTVSSGASTATTSESSTTSSGASTATNSESSTVSSGASTATNSESSTTS 429

Query: 444 SGRGGSGGGSSS----GSSSSSSSSSSSSSSSSSSSSPSSSSGG 483
           SG   +    SS    GS +++ +   ++S S+S++   +  GG
Sbjct: 430 SGANTATNSGSSVTSAGSGTAALTGMHTTSHSASTAVSEAKPGG 473


>gi|57864582 hornerin [Homo sapiens]
          Length = 2850

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 114/455 (25%), Positives = 169/455 (37%), Gaps = 36/455 (7%)

Query: 73   EGPPPQNSDENRGGDSSDDVSNGDSIIDWLNS--VRQTGNTTRSGQRGNQSWRAVSRTNP 130
            + P P       G   S   S   S   W +S    ++G++  SG    +S     R+  
Sbjct: 1475 QSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRES-----RSGQ 1529

Query: 131  NSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSR 190
            +SG  +       +  +G   S +    S  +    + +++S  Q  +  S+S+      
Sbjct: 1530 SSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQG 1589

Query: 191  SERNSTEALTEVPPTRGQRRARSR-SPDHRRTRARAERSRSPLHPMSEIPRRS----HHS 245
            S    +       P  GQR + SR SP + R  + + RS S     S +   S    H S
Sbjct: 1590 SGSGQS-------PGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHES 1642

Query: 246  ISSQTFEHPLVNETEG-SSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTA 304
             S Q+  +       G SS    H +   Q S  E    G  + S +R    G+GS  ++
Sbjct: 1643 SSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSRSSSRYGQHGSGSRQSS 1700

Query: 305  ASG-ESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGF 363
              G + +GSGQ P          R R G      S   +  S S   ++   YES R G 
Sbjct: 1701 GHGRQGSGSGQSPS---------RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYES-RSGH 1750

Query: 364  RRTFSRSER-AGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYS 422
               F + E  +G  +  S          + G   +TS    T   Q  +  G+ S     
Sbjct: 1751 SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTF-DQEGSSTGQSSSHGQH 1809

Query: 423  DSDSEPTGSVSNRNMERAESRS-GRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
             S S  + S   +     +S S GR GSG G SS      S S  SSSS    S    SS
Sbjct: 1810 GSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSS 1869

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSGARREGRHRA 516
            G    E+SS    G  +  S SG S +  +   R+
Sbjct: 1870 GFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRS 1904



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 93/414 (22%), Positives = 153/414 (36%), Gaps = 71/414 (17%)

Query: 108 TGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGEN 167
           +G+++  GQ G+ S  + SR +  SG  + S        +G  +  +++   +  SS + 
Sbjct: 316 SGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQG 375

Query: 168 VENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARS-RSPDHRRTRARAE 226
              ++  Q  +     +S+R S S     E+ +     RGQ  + S +SP H +  + + 
Sbjct: 376 QHGSTSGQASSSGQHGSSSRQS-SSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSG 434

Query: 227 RSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLF 286
           +S S     +   R S           P V+ +  SS   HH +  +  SG         
Sbjct: 435 QSPSSGQHGTGFGRSSSSG--------PYVSGSGYSSGFGHHESSSEHSSG--------- 477

Query: 287 AASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSR 346
                     G+GS      G S+G GQ                  +  R   +SR   +
Sbjct: 478 ------YTQHGSGS------GHSSGHGQ------------------HGSRSGQSSRGERQ 507

Query: 347 SQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTML 406
             +  ++ +Y     G R++   S                     +G S + S       
Sbjct: 508 GSSAGSSSSYGQHGSGSRQSLGHSRHGS----------------GSGQSPSPSRGRHESG 551

Query: 407 RQIMTGFGELSYFMYSDSDSEP--TGSVSNRNMERAESRSGRGGSGG--GSSSGSSSSSS 462
            +  + +G   Y     S   P  +GS  +  +   ESRSG+    G  GSSSG SS+  
Sbjct: 552 SRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHG 611

Query: 463 SSSSSSSSSSSSSSPSSSSGGESS--ETSSDLFEGSNEGSSSSGSSGARREGRH 514
              S+S  SSS     ++SG  SS  +  S   + S  G   SGS  +   GRH
Sbjct: 612 QHGSTSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRH 665



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 110/455 (24%), Positives = 165/455 (36%), Gaps = 36/455 (7%)

Query: 73   EGPPPQNSDENRGGDSSDDVSNGDSIIDWLNS--VRQTGNTTRSGQRGNQSWRAVSRTNP 130
            + P P       G   S       S   W +S    ++G+   SG    +S     R+  
Sbjct: 1005 QSPSPSRGRHGSGSGQSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRES-----RSGQ 1059

Query: 131  NSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSR 190
            +SG  +       +  +G   S +    S  +    + +++S  Q  +  S+S+      
Sbjct: 1060 SSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQG 1119

Query: 191  SERNSTEALTEVPPTRGQRRARSR-SPDHRRTRARAERSRSPLHPMSEIPRRS----HHS 245
            S    +       P  GQR + SR SP + R  + + RS S     S +   S    H S
Sbjct: 1120 SGSGQS-------PGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHES 1172

Query: 246  ISSQTFEHPLVNETEG-SSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTA 304
             S Q+  +       G SS    H +   Q S  E    G  + S +     G+GS  ++
Sbjct: 1173 SSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSGSSSHYGQHGSGSRQSS 1230

Query: 305  ASG-ESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGF 363
              G + +GSG  P          R R G      S   +  S S   ++   YES R G 
Sbjct: 1231 GHGRQGSGSGHSPS---------RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYES-RSGH 1280

Query: 364  RRTFSRSER-AGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYS 422
               F + E  +G  +  S          + G   +TS    T   Q  +  G+ S + + 
Sbjct: 1281 SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTF-DQEGSSTGQSSSYGHR 1339

Query: 423  DSDSEPTGSVSNRNMERAESRS-GRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
             S S  +           +S S GR GSG G SS      S S  SSSS    S    SS
Sbjct: 1340 GSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSS 1399

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSGARREGRHRA 516
            G    E+SS    G  +  S SG S +  +   R+
Sbjct: 1400 GFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRS 1434



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 111/455 (24%), Positives = 165/455 (36%), Gaps = 36/455 (7%)

Query: 73   EGPPPQNSDENRGGDSSDDVSNGDSIIDWLNS--VRQTGNTTRSGQRGNQSWRAVSRTNP 130
            + P P       G   S       S   W +S    ++G+   SG    +S     R+  
Sbjct: 1945 QSPSPSRGRHGSGSGQSSSYGPYGSGSGWSSSRGPYESGSGHSSGLGHRES-----RSGQ 1999

Query: 131  NSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSR 190
            +SG  +       +  +G   S +    S  +    + +++S  Q  +  S+S+      
Sbjct: 2000 SSGYGQHGSSSGHSSTHGQHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQG 2059

Query: 191  SERNSTEALTEVPPTRGQRRARSR-SPDHRRTRARAERSRSPLHPMSEIPRRS----HHS 245
            S    +       P  GQR + SR SP + R  + + RS S       +   S    H S
Sbjct: 2060 SGSGQS-------PGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGPGLGESSGFGHHES 2112

Query: 246  ISSQTFEHPLVNETEG-SSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTA 304
             S Q+  +       G SS    H +   Q S  E    G  + S +R    G+GS  ++
Sbjct: 2113 SSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSGSSSRYGQHGSGSRQSS 2170

Query: 305  ASG-ESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGF 363
              G + +GSG  P          R R G      S   +  S S   ++   YES R G 
Sbjct: 2171 GHGRQGSGSGHSPS---------RGRHGSGSGHSSSHGQHGSGSGRSSSRGPYES-RSGH 2220

Query: 364  RRTFSRSER-AGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYS 422
               F + E  +G  +  S          + G   +TS    T   Q  +  G+ S     
Sbjct: 2221 SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTF-DQEGSSTGQSSSHGQH 2279

Query: 423  DSDSEPTGSVSNRNMERAESRS-GRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSS 481
             S S  + S   +     +S S GR GSG G SS      S S  SSSS    S    SS
Sbjct: 2280 GSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSS 2339

Query: 482  GGESSETSSDLFEGSNEGSSSSGSSGARREGRHRA 516
            G    E+SS    G  +  S SG S +  +   R+
Sbjct: 2340 GFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRS 2374



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 113/436 (25%), Positives = 160/436 (36%), Gaps = 49/436 (11%)

Query: 108  TGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGEN 167
            +G  +  GQ  + S +  S+    SG   FS +      +G  +S  +++ S+ +SS   
Sbjct: 811  SGQASGFGQHESGSGQGYSQHGSASG--HFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYG 868

Query: 168  VENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARS-RSPDHRRTRARAE 226
                        + ES S   S   R+ + +     P  GQR + S +SP + R  + + 
Sbjct: 869  ------------QHESASHHASGRGRHGSGSGQS--PGHGQRGSGSGQSPSYGRHGSGSG 914

Query: 227  RSRSPLHPMSEIPRRS---HHSISSQTFEHPLVNETEG-SSRTRHHVTLRQQISGPELLS 282
            RS S     S   + S   H S S Q+  +       G SS    H +   Q S  E   
Sbjct: 915  RSSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSE--Q 972

Query: 283  RGLFAASGTRNASQGAGSSDTAASGE-STGSGQRPPTIVLDLQVRRVRPGEYRQRDSIAS 341
             G  + S +     G+GS  +   G+  +GSGQ P          R R G    + S   
Sbjct: 973  HGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-------SRGRHGSGSGQSSSYG 1025

Query: 342  RTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVA 401
              RS S   ++   YES  G       R  R+G  +         +   ++G S T    
Sbjct: 1026 PYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYG------QHGSSSGHSSTHGQH 1079

Query: 402  IQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSS 461
              T  +    G    S    S      +GS  +    R  S SG+    G   SGS  S 
Sbjct: 1080 GSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQSP 1139

Query: 462  SSSSSSSSSSSSSSSPSSSSG-GESS----------ETSSDLFEGSNEGSSSS-GSSGAR 509
            S     S S  SSSS    SG GESS          ++SS    GS  G SS  G  G+R
Sbjct: 1140 SYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSR 1199

Query: 510  REGRHRAPVTFDESGS 525
                 R       SGS
Sbjct: 1200 SGQSSRGERHGSSSGS 1215



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 114/508 (22%), Positives = 194/508 (38%), Gaps = 73/508 (14%)

Query: 18  QRRSQMDRLDREEAFYQFVNNLSEEDYRLMRDNNLLGTPGESTEEELLRRLQQIKEGPPP 77
           Q  ++ +   R+E+ +   +  + E+    R  N+ G+    TE  + RRL   ++    
Sbjct: 112 QEETEKEENKRQESSFSHSSWSAGENDSYSR--NVRGSLKPGTES-ISRRLSFQRDFSGQ 168

Query: 78  QNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRF 137
            NS    G  SS    N DS             ++  GQ G+ S ++ +     SG  + 
Sbjct: 169 HNSYS--GQSSSYGEQNSDS-----------HQSSGRGQCGSGSGQSPNYGQHGSGSGQS 215

Query: 138 SLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVEN-PRSESTSARPSRSERNST 196
           S        +G  +  ++++ S+ +SSG +   +         +  S S + SR ER+ +
Sbjct: 216 SSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRS 275

Query: 197 EALTEVPPTRGQRRARSR-SPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPL 255
            + +    + GQ  + SR S  H R  + + +S S +          H S S  +  H  
Sbjct: 276 SSGSS--SSYGQHGSGSRQSLGHGRQGSGSRQSPSHVR---------HGSGSGHSSSHGQ 324

Query: 256 VNETEGSSRTR-HHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDT-----AASGES 309
                  S +R H+ +   Q SG      G   +SG      G+G S +     + SG++
Sbjct: 325 HGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQA 384

Query: 310 TGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFS- 368
           + SGQ   +          +   Y Q +S +  +  R Q  +++ + +S   G R + S 
Sbjct: 385 SSSGQHGSS--------SRQSSSYGQHESASRHSSGRGQ--HSSGSGQSPGHGQRGSGSG 434

Query: 369 RSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEP 428
           +S  +G                 TG   ++S          ++G G  S F + +S SE 
Sbjct: 435 QSPSSGQH--------------GTGFGRSSSSG------PYVSGSGYSSGFGHHESSSEH 474

Query: 429 TGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSET 488
           +   +          SG G S G    GS S  SS      SS+ SSS     G  S ++
Sbjct: 475 SSGYTQHG-------SGSGHSSGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQS 527

Query: 489 SSDLFEGSNEGSSSSGSSGARREGRHRA 516
                 GS  G S S S G    G  ++
Sbjct: 528 LGHSRHGSGSGQSPSPSRGRHESGSRQS 555



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 111/450 (24%), Positives = 163/450 (36%), Gaps = 55/450 (12%)

Query: 73   EGPPPQNSDENRGGDSSDDVSNGDSIIDWLNS--VRQTGNTTRSGQRGNQSWRAVSRTNP 130
            + P P       G   S   S   S   W +S    ++G+   SG    +S     R+  
Sbjct: 2415 QSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRES-----RSGQ 2469

Query: 131  NSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSR 190
            +SG  +       +  +G   S +    S  +    + +++S  Q  +  S+S+      
Sbjct: 2470 SSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQG 2529

Query: 191  SERNSTEALTEVPPTRGQRRARSR-SPDHRRTRARAERSRSPLHPMSEIPRRS----HHS 245
            S    +       P  GQR + SR SP + R  + + RS S     S +   S    H S
Sbjct: 2530 SGSGQS-------PGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHES 2582

Query: 246  ISSQTFEHPLVNETEG-SSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTA 304
             S Q+  +       G SS    H +   Q S  E    G  + S +     G+GS  ++
Sbjct: 2583 SSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE--RHGSSSGSSSHYGQHGSGSRQSS 2640

Query: 305  ASG-ESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGF 363
              G + +GSGQ P          R R G      S   +  S S   ++   YES R G 
Sbjct: 2641 GHGRQGSGSGQSPS---------RGRHGSGLGHSSSHGQHGSGSGRSSSRGPYES-RLGH 2690

Query: 364  RRTFSRSER-AGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYS 422
               F + E  +G  +  S          + G   +TS              G+ S F   
Sbjct: 2691 SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTS--------------GQSSTFDQE 2736

Query: 423  DSDSEPTGSVSNRNMERAESRS-GRGGSGGGSS-----SGSSSSSSSSSSSSSSSSSSSS 476
             S +  + S  +R    ++S   GR G+G G S      GS S  SSS     S S  SS
Sbjct: 2737 GSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSLSHGRHGSGSGQSSSYGQHGSGSGQSS 2796

Query: 477  PSSSSG-GESSETSSDLFEGSNEGSSSSGS 505
              S  G G   +  S    GSN    SSGS
Sbjct: 2797 GYSQHGSGSGQDGYSYCKGGSNHDGGSSGS 2826



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 104/420 (24%), Positives = 157/420 (37%), Gaps = 52/420 (12%)

Query: 108  TGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGEN 167
            +G +   G+ G+ S  + S     SG    S        +G  +    +E S+ +SSG  
Sbjct: 2296 SGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYT 2355

Query: 168  VENN-SQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSR-SPDHRRTRARA 225
               + S       +  S S + SR ER+ + + +    + GQ  + SR S  H +  + +
Sbjct: 2356 QHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSS--SSYGQHGSGSRQSLGHGQHGSGS 2413

Query: 226  ERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGL 285
             +S SP        R  H S S Q+  +       G S +R          GP     G 
Sbjct: 2414 GQSPSP-------SRGRHGSGSGQSSSYSPYGSGSGWSSSR----------GPYESGSGH 2456

Query: 286  FAASGTRNASQGAGSS---DTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASR 342
             +  G R +  G  S      ++SG S+  GQ   T          +     Q  + + +
Sbjct: 2457 SSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGST--------SGQSSSCGQHGASSGQ 2508

Query: 343  TRSRSQTPNNTVTYESERGGFRRTFSRSERA---GVRTYVSTIRIPIRRILNTGLSETTS 399
            + S  Q  + +    S+  G+ R  S S ++   G R   S  + P      +G   ++S
Sbjct: 2509 SSSHGQHGSGS----SQSSGYGRQGSGSGQSPGHGQRGSGSR-QSPSYGRHGSGSGRSSS 2563

Query: 400  VAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRS-GRGGSGGGSSS--- 455
                    Q  +G GE S F + +S S  + S S        S   G+ GS  G SS   
Sbjct: 2564 SG------QHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGE 2617

Query: 456  --GSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGR 513
              GSSS SSS      S S  SS     G  S ++ S    GS  G SSS        GR
Sbjct: 2618 RHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSPSRGRHGSGLGHSSSHGQHGSGSGR 2677



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 93/432 (21%), Positives = 154/432 (35%), Gaps = 42/432 (9%)

Query: 107  QTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGE 166
            ++G ++R  + G+ S  +       SG  + S        +G Q S + + PS  R    
Sbjct: 1199 RSGQSSRGERHGSSSGSSSHYGQHGSGSRQSS-------GHGRQGSGSGHSPSRGRHGSG 1251

Query: 167  NVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAE 226
               ++S  Q  +    S+S  P  S    +    +     G   A S+            
Sbjct: 1252 LGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQG 1311

Query: 227  RSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQIS-GPELLSRGL 285
            +  S     S   +    +  S ++ H     ++ S   RH     Q  S G      G 
Sbjct: 1312 QHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGH 1371

Query: 286  FAASGTRNASQGAGSSDT---AASGESTGSGQRPPTIVLDLQVRRVRPG--------EYR 334
             ++ G   +  G  SS     + SG+S+G G    +        +   G        ++ 
Sbjct: 1372 SSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHG 1431

Query: 335  QRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGL 394
             R   +SR      +  ++ +Y     G R++    +         +   P R    +G 
Sbjct: 1432 SRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPS---PSRGRHGSGS 1488

Query: 395  SETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGG--G 452
             +++S +           +G  S +  S    E +GS  +  +   ESRSG+    G  G
Sbjct: 1489 GQSSSYS----------PYGSGSGWSSSRGPYE-SGSSHSSGLGHRESRSGQSSGYGQHG 1537

Query: 453  SSSGSSSSSSSSSSSSSSSSS------SSSPSSSSGGESSETS-SDLFEGSNEGSSSSGS 505
            SSSG SS+     S+S  SSS      SS  SSS G   S +S S  +     GS  S  
Sbjct: 1538 SSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPG 1597

Query: 506  SGARREGRHRAP 517
             G R  G  ++P
Sbjct: 1598 HGQRGSGSRQSP 1609



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 105/456 (23%), Positives = 162/456 (35%), Gaps = 68/456 (14%)

Query: 83  NRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEIN 142
           +R G SS     G S           G+++  GQ G+ S +++  +   SG  +      
Sbjct: 496 SRSGQSSRGERQGSS----------AGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSR 545

Query: 143 VNRNNGSQNSEN---ENEPSARRSSGENVENNSQRQVENPRSESTSARPSR-SERNSTEA 198
               +GS+ S +       S R SS    E+ S         ES S + S   +  S+  
Sbjct: 546 GRHESGSRQSSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSG 605

Query: 199 LTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNE 258
            +      G    +S S       +    S              H S SSQ+  +     
Sbjct: 606 HSSTHGQHGSTSGQSSSCGQHGATSGQSSSHG-----------QHGSGSSQSSRYGQQGS 654

Query: 259 TEGSS--RTRHHVTLRQQIS-GPELLSRGLFAASGTRNA--SQGAGSSDTAASGESTGSG 313
             G S  R RH        S G      G  +++G   +   Q +G    + SG+S+G  
Sbjct: 655 GSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYS 714

Query: 314 QRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERA 373
           Q           R+     +  R   +SR+     +   + +Y     G  ++ S   R 
Sbjct: 715 QHGSGSSHSSGYRK-----HGSRSGQSSRSEQHGSSSGLSSSYGQHGSGSHQS-SGHGRQ 768

Query: 374 GVRTYVSTIRIPIRRILNTGLSET-----TSVAIQTMLRQIMTGFGELSYFMYSDSDSEP 428
           G  +  S  R+  R   ++G S +     +  +  +      +G G+ S F         
Sbjct: 769 GSGSGHSPSRV--RHGSSSGHSSSHGQHGSGTSCSSSCGHYESGSGQASGF--------- 817

Query: 429 TGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESS-- 486
                     + ES SG+G S  GS+SG  SS     S+S  SSSS    SSSG  SS  
Sbjct: 818 ---------GQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSSSSGQHDSSSGQSSSYG 868

Query: 487 --ETSSDLFEGSNEGSSSSGSS---GARREGRHRAP 517
             E++S    G     S SG S   G R  G  ++P
Sbjct: 869 QHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSP 904



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 101/445 (22%), Positives = 155/445 (34%), Gaps = 43/445 (9%)

Query: 108  TGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARR--SSG 165
            +G+++  GQ G+ S R+ SR    S     S+       +G  ++ +++   +    S G
Sbjct: 2192 SGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQG 2251

Query: 166  ENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARS-RSPDHRRTRAR 224
            ++   + Q    +    ST    S  +  S  + +    + GQ+ + S +SP   R  + 
Sbjct: 2252 QHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSS---SYGQQGSGSGQSPSRGRHGSG 2308

Query: 225  AERSRSPLHP------MSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGP 278
            +  S S           S   R    S  S  F H   +  + S  T+H        S  
Sbjct: 2309 SGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYE 2368

Query: 279  ELLSRGLFAASGTRNASQGAGSSDTAASG----ESTGSGQRPPTIVLDLQVRRVRPGEYR 334
            +  SR   ++ G R+ S    SS     G    +S G GQ            R R G   
Sbjct: 2369 QHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGS 2428

Query: 335  QRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGL 394
             + S  S   S S   ++   YES  G       R  R+G  +               G 
Sbjct: 2429 GQSSSYSPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQ 2488

Query: 395  SETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTG-----SVSNRNMERAE-------- 441
              +TS    +  +   +     S+  +    S+ +G     S S ++    +        
Sbjct: 2489 HGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQS 2548

Query: 442  -------------SRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSG-GESSE 487
                         S SG+ GSG G SSG     SSS  SSS S   S    SSG G+   
Sbjct: 2549 PSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGS 2608

Query: 488  TSSDLFEGSNEGSSSSGSSGARREG 512
             S     G   GSSS  SS   + G
Sbjct: 2609 RSGQSSRGERHGSSSGSSSHYGQHG 2633



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 45/192 (23%), Positives = 80/192 (41%), Gaps = 18/192 (9%)

Query: 327 RVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTI--RI 384
           ++R   ++ ++      +  ++   ++ ++ S   G   ++SR+ R  ++    +I  R+
Sbjct: 100 KLRDDTHQHQEEQEETEKEENKRQESSFSHSSWSAGENDSYSRNVRGSLKPGTESISRRL 159

Query: 385 PIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRS 444
             +R  +    +  S + Q+      + +GE +   +  S     GS S ++    +  S
Sbjct: 160 SFQRDFS---GQHNSYSGQS------SSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGS 210

Query: 445 GRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSG 504
           G G S    + GS S  SS  S   SSS  SS  S  G  S  +S     GS  G SS G
Sbjct: 211 GSGQSSSNDTHGSGSGQSSGFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRG 270

Query: 505 SSGARREGRHRA 516
                   RHR+
Sbjct: 271 E-------RHRS 275



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 70/292 (23%), Positives = 108/292 (36%), Gaps = 40/292 (13%)

Query: 243 HHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSD 302
           H+S S Q+  +   N     S  R         S P     G  +   + N + G+GS  
Sbjct: 169 HNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQS-PNYGQHGSGSGQSSSNDTHGSGSGQ 227

Query: 303 TA-------ASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVT 355
           ++       +SG+S+G  Q                G++  R   +SR      +  ++ +
Sbjct: 228 SSGFSQHKSSSGQSSGYSQHGSG-----SGHSSGYGQHGSRSGQSSRGERHRSSSGSSSS 282

Query: 356 YESERGGFRRTFSRSER-AGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFG 414
           Y     G R++     + +G R   S +R        +G   ++S              G
Sbjct: 283 YGQHGSGSRQSLGHGRQGSGSRQSPSHVRH------GSGSGHSSSHGQH----------G 326

Query: 415 ELSYFMYSDSDSEPTGSVSNRNMERAESRSGRG------GSGGGSSSGSSSSSSSSSSSS 468
             S + YS    E +GS       + ES SG+       GSG G SS      S+S  +S
Sbjct: 327 SGSSYSYSRGHYE-SGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSSQGQHGSTSGQAS 385

Query: 469 SSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSS---GARREGRHRAP 517
           SS    SS   SS     E++S    G  + SS SG S   G R  G  ++P
Sbjct: 386 SSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSGQSPGHGQRGSGSGQSP 437



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 115/493 (23%), Positives = 174/493 (35%), Gaps = 66/493 (13%)

Query: 74   GPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQ----TGNTTRSGQRGNQSWRAVSRTN 129
            G  P       G   S       S   W +S  +    +G ++  G   + SW++   T 
Sbjct: 1357 GQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGFGHHESSSWQSSGCTQ 1416

Query: 130  PNSGD-FRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSAR- 187
              SG     S E + +R+  S   E     S   SS     + S++ + + +  S S + 
Sbjct: 1417 HGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQS 1476

Query: 188  --PSRSERNST--EALTEVPPTRGQRRARSRSP-----------DHRRTRARAERSRSPL 232
              PSR    S   ++ +  P   G   + SR P            HR +R+  + S    
Sbjct: 1477 PSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGPYESGSSHSSGLGHRESRS-GQSSGYGQ 1535

Query: 233  HPMSE---IPRRSHHSISSQTFEHPLVNETEGSSRTR-HHVTLRQQISG----------- 277
            H  S         H S S Q+        + G S +   H +   Q SG           
Sbjct: 1536 HGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQS 1595

Query: 278  PELLSRGLFAASGTRNASQGAGSSDTAASG-------ESTGSGQRPPTIVLDLQVRRVRP 330
            P    RG  +         G+GS  +++SG       ES+G G    +        +   
Sbjct: 1596 PGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGS 1655

Query: 331  GE-----YRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIP 385
            G      Y Q  S + ++ SR +   ++ +  S R G   + SR      R    + + P
Sbjct: 1656 GSGHSSGYGQHGSRSGQS-SRGERHGSS-SRSSSRYGQHGSGSRQSSGHGRQGSGSGQSP 1713

Query: 386  IRRILNTGLSETTSVAIQTMLRQIMTGFGELS----YFMYSDSDSEPTGSVSNRNMERAE 441
             R    +GL  ++S        Q  +G G  S    Y   S   S      S      A 
Sbjct: 1714 SRGRHGSGLGHSSSHG------QHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAY 1767

Query: 442  SRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSS 501
            S+ G  GSG   S G   S+S  SS+     SS+  SSS G   S +S    + S+ G  
Sbjct: 1768 SQHG-SGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSS----QSSSYGQQ 1822

Query: 502  SSGSSGARREGRH 514
             SGS  +   GRH
Sbjct: 1823 GSGSGQSPSRGRH 1835



 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 95/414 (22%), Positives = 143/414 (34%), Gaps = 72/414 (17%)

Query: 108 TGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGEN 167
           +G ++  GQ G  S ++ S     SG  + S         G Q S +   PS  R   + 
Sbjct: 617 SGQSSSCGQHGATSGQSSSHGQHGSGSSQSS-------RYGQQGSGSGQSPSRGRHGSDF 669

Query: 168 VENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAER 227
             ++S  Q  +    S+S  P  S    +          G +    +S  + +  + +  
Sbjct: 670 GHSSSYGQHGSGSGWSSSNGPHGSVSGQSSGF-------GHKSGSGQSSGYSQHGSGSSH 722

Query: 228 SRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFA 287
           S            R H S S Q            SSR+  H +           S GL +
Sbjct: 723 SSG---------YRKHGSRSGQ------------SSRSEQHGS-----------SSGLSS 750

Query: 288 ASGTRNASQGAGSSDTAASG-ESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSR 346
           + G      G+GS  ++  G + +GSG  P          RVR G      S   +  S 
Sbjct: 751 SYG----QHGSGSHQSSGHGRQGSGSGHSPS---------RVRHGSSSGHSSSHGQHGSG 797

Query: 347 SQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTML 406
           +   ++   YES  G     F + E    + Y S          + G   +TS    +  
Sbjct: 798 TSCSSSCGHYESGSGQ-ASGFGQHESGSGQGY-SQHGSASGHFSSQGRHGSTSGQSSSSG 855

Query: 407 RQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSS-------SGSSS 459
           +   +     SY  +  +    +G   + +        G+ GSG G S       SGS  
Sbjct: 856 QHDSSSGQSSSYGQHESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGR 915

Query: 460 SSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGR 513
           SSSS    S S  SS     SS G+SS  +     GS  G SSS      R G+
Sbjct: 916 SSSSGRHGSGSGQSSGFGHKSSSGQSSGYTQ---HGSGSGHSSSYEQHGSRSGQ 966



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 102/426 (23%), Positives = 157/426 (36%), Gaps = 60/426 (14%)

Query: 115  GQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNN---GSQNSENENEPSARRSSGENVENN 171
            G R  QS R     + +    R+    + +R +   G Q S + + PS  R    +  ++
Sbjct: 2137 GSRSGQSSRGERHGSSSGSSSRYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGSGHSS 2196

Query: 172  SQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSP 231
            S  Q  +    S+S  P  S    +          GQ  + S       + A ++     
Sbjct: 2197 SHGQHGSGSGRSSSRGPYESRSGHSSVF-------GQHESGSG-----HSSAYSQHGSGS 2244

Query: 232  LHPMSEIPRRSHHSISSQ--TFEHPLVNETEGSSRTRH------HVTLRQQISGP-ELLS 282
             H  S+     H S S Q  TF+    +  + SS  +H        +  QQ SG  +  S
Sbjct: 2245 GHFCSQ---GQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGSGQSPS 2301

Query: 283  RGLFAASGTRNAS---QGAGSSDTAASGE-STGSGQRPPTIVLDLQVRRVRPGEYRQRDS 338
            RG   +    ++S    G+GS  +++SG   +GSGQ                G +     
Sbjct: 2302 RGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSSGF------------GHHESSSW 2349

Query: 339  IASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIR----IPIRRILNTGL 394
             +S          ++ +YE + G      SR ER G  +  S+         R+ L  G 
Sbjct: 2350 QSSGYTQHGSGSGHSSSYE-QHGSRSGQSSRGERHGSSSGSSSSYGQHGSGSRQSLGHGQ 2408

Query: 395  SETTSVAIQTMLR-QIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGS 453
              + S    +  R +  +G G+ S +        P GS S  +  R    SG G S G  
Sbjct: 2409 HGSGSGQSPSPSRGRHGSGSGQSSSY-------SPYGSGSGWSSSRGPYESGSGHSSGLG 2461

Query: 454  SSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSS----GSSGAR 509
               S S  SS      SSS  SS     G  S ++SS    G++ G SSS    GS  ++
Sbjct: 2462 HRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQ 2521

Query: 510  REGRHR 515
              G  R
Sbjct: 2522 SSGYGR 2527



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 102/430 (23%), Positives = 149/430 (34%), Gaps = 49/430 (11%)

Query: 108  TGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGEN 167
            +G +   GQRG+ S ++ S     SG  R S         G  +    +E S+ +SS  +
Sbjct: 1122 SGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYS 1181

Query: 168  VENNSQRQVEN-PRSESTSARPSRSERNSTEALTEVPPTRGQRRARSR-SPDHRRTRARA 225
               +         +  S S + SR ER+ + + +      GQ  + SR S  H R  + +
Sbjct: 1182 QHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSS--SHYGQHGSGSRQSSGHGRQGSGS 1239

Query: 226  ERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGL 285
              S S         R  H S    +  H       G S +R          GP     G 
Sbjct: 1240 GHSPS---------RGRHGSGLGHSSSHGQHGSGSGRSSSR----------GPYESRSGH 1280

Query: 286  FAASGTRNASQG---AGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASR 342
             +  G   +  G   A S   + SG     GQ   T          +   + Q  S   +
Sbjct: 1281 SSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGST--------SGQSSTFDQEGSSTGQ 1332

Query: 343  TRS---RSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTS 399
            + S   R    + +  Y     G  ++ SR        + S+          +G   ++S
Sbjct: 1333 SSSYGHRGSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQH-----GSGSGWSSS 1387

Query: 400  VAIQTMLRQIMTGFG--ELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGG--GSSS 455
                       +GFG  E S +  S      +GS  + + E+  SRSG+   G   GSSS
Sbjct: 1388 SGRHGSGSGQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSS 1447

Query: 456  GSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHR 515
            GSSSS     S S  S       S SG   S +      GS + SS S           R
Sbjct: 1448 GSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSR 1507

Query: 516  APVTFDESGS 525
             P    ESGS
Sbjct: 1508 GPY---ESGS 1514



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 100/438 (22%), Positives = 150/438 (34%), Gaps = 48/438 (10%)

Query: 107  QTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSS-- 164
            ++G+++  GQ  + S  + + +   SG   F  +      +G  ++ ++   S  +SS  
Sbjct: 1747 RSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSH 1806

Query: 165  GENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRAR 224
            G++   +SQ      +   +   PSR    S    +      G     S S     + + 
Sbjct: 1807 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGS- 1865

Query: 225  AERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRG 284
                        +     HH  SS          T+  S + H  +  Q  S     SRG
Sbjct: 1866 -----------GQSSGFGHHESSSWQSS----GYTQHGSGSGHSSSYEQHGSRSGQSSRG 1910

Query: 285  LFAASGTRNASQ----GAGSSDTAASGE-STGSGQRPPTIVLDLQVRRVRPGEYRQRDSI 339
                S + ++S     G+GS  +   G+  +GSGQ P          R R G    + S 
Sbjct: 1911 EQHGSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSP-------SRGRHGSGSGQSSS 1963

Query: 340  ASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTS 399
                 S S   ++   YES  G       R  R+G  +         +   ++G S T  
Sbjct: 1964 YGPYGSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYG------QHGSSSGHSSTHG 2017

Query: 400  VAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSS 459
                   +    G    S    S      +GS  +    R  S SG+    G   SGS  
Sbjct: 2018 QHGSASGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGSGSGQSPGHGQRGSGSRQ 2077

Query: 460  SSSSSSSSSSSSSSSSSPSSSSG-GESS----------ETSSDLFEGSNEGSSSS-GSSG 507
            S S     S S  SSSS     G GESS          ++SS    GS  G SS  G  G
Sbjct: 2078 SPSYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHG 2137

Query: 508  ARREGRHRAPVTFDESGS 525
            +R     R       SGS
Sbjct: 2138 SRSGQSSRGERHGSSSGS 2155



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 109/505 (21%), Positives = 168/505 (33%), Gaps = 76/505 (15%)

Query: 54   GTPGESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQ----TG 109
            G  G  + +      Q    G  P       G   S       S   W +S  +    +G
Sbjct: 2277 GQHGSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSG 2336

Query: 110  NTTRSGQRGNQSWRAVSRTNPNSGD-FRFSLEINVNRNNGSQNSENENEPSARRSSGENV 168
             ++  G   + SW++   T   SG     S E + +R+  S   E     S   SS    
Sbjct: 2337 QSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYGQH 2396

Query: 169  ENNSQRQVENPRSESTSAR---PSRSERNST--EALTEVPPTRGQRRARSRSPDHRRTRA 223
             + S++ + + +  S S +   PSR    S   ++ +  P   G   + SR P      +
Sbjct: 2397 GSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWSSSRGP----YES 2452

Query: 224  RAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSR 283
             +  S    H  S   + S +     +  H   +   GS+  +     +   S  +  S 
Sbjct: 2453 GSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSCGQHGASSGQSSSH 2512

Query: 284  GLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRT 343
            G   +  ++++  G   S    SG+S G GQR           R  P  Y +  S + R+
Sbjct: 2513 GQHGSGSSQSSGYGRQGS---GSGQSPGHGQRGSG-------SRQSPS-YGRHGSGSGRS 2561

Query: 344  RSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQ 403
             S  Q  +       E  GF    S S ++   +   +          +G S        
Sbjct: 2562 SSSGQHGSGL----GESSGFGHHESSSGQSSSYSQHGS---------GSGHS-------- 2600

Query: 404  TMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAE------SRSGRGGSGGGS---- 453
                   +G+G+        S  E  GS S  +    +        SG G  G GS    
Sbjct: 2601 -------SGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGQSP 2653

Query: 454  SSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSS---------SSG 504
            S G   S    SSS     S S  SSS G   S        G +E  S          SG
Sbjct: 2654 SRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYSQHGSG 2713

Query: 505  SSGARREGRHRA----PVTFDESGS 525
            S     +G+H +      TFD+ GS
Sbjct: 2714 SGHFCSQGQHGSTSGQSSTFDQEGS 2738



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 101/432 (23%), Positives = 157/432 (36%), Gaps = 53/432 (12%)

Query: 107  QTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGE 166
            ++G ++RS Q G+ S  + S     SG  R SL    +  +GS + ++ +    R  SG 
Sbjct: 963  RSGQSSRSEQHGSSSGSSSSYGQHGSGS-RQSLG---HGQHGSGSGQSPSPSRGRHGSGS 1018

Query: 167  NVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSR---SPDHRRTRA 223
              +++S     +    S+S  P  S    +  L       GQ     +   S  H  T  
Sbjct: 1019 G-QSSSYGPYRSGSGWSSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHG 1077

Query: 224  R-----AERSRSPLHPMSEIPRRSHH---SISSQTFEHPLVNETEGSSRTRHHVTLRQQI 275
            +      + S    H  S     SH    S SSQ+  +    +  GS ++  H    Q+ 
Sbjct: 1078 QHGSTSGQSSSCGQHGASSGQSSSHGQHGSGSSQSSGYG--RQGSGSGQSPGH---GQRG 1132

Query: 276  SGP-ELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPG--- 331
            SG  +  S G   +   R++S G   S     GES+G G    +        +   G   
Sbjct: 1133 SGSRQSPSYGRHGSGSGRSSSSGQHGSGL---GESSGFGHHESSSGQSSSYSQHGSGSGH 1189

Query: 332  -----EYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPI 386
                 ++  R   +SR      +  ++  Y     G R++     +        +   P 
Sbjct: 1190 SSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGS-----GSGHSPS 1244

Query: 387  RRILNTGLSETTSVAIQTMLRQIMTGFGELS----YFMYSDSDSEPTGSVSNRNMERAES 442
            R    +GL  ++S        Q  +G G  S    Y   S   S      S      A S
Sbjct: 1245 RGRHGSGLGHSSSHG------QHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYS 1298

Query: 443  RSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSS 502
            + G  GSG   S G   S+S  SS+     SS+  SSS G   S +S    + S  G   
Sbjct: 1299 QHG-SGSGHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSYGHRGSGSS----QSSGYGRHG 1353

Query: 503  SGSSGARREGRH 514
            +GS  +   GRH
Sbjct: 1354 AGSGQSPSRGRH 1365


>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
          Length = 717

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 43/100 (43%), Positives = 56/100 (56%), Gaps = 6/100 (6%)

Query: 425 DSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSS------SSSSPS 478
           +S+      +R+  RA +++ +  S   SSS SSSSS+SSSS SSSSS      SSSS S
Sbjct: 551 ESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSS 610

Query: 479 SSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPV 518
           SS+ G SS  SS     S+E  S S   G  R+ +HR  V
Sbjct: 611 SSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSV 650



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 43/93 (46%), Positives = 53/93 (56%), Gaps = 3/93 (3%)

Query: 427 EPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESS 486
           EP  +V   +  + ++RS   G     +S S S SSSSSSSSSSS+SSSS SSSS G SS
Sbjct: 543 EPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSS 602

Query: 487 ETSSDLFEGSNEGSS---SSGSSGARREGRHRA 516
             SS     S  GSS   SS S+ +  E R R+
Sbjct: 603 SRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRS 635



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 33/94 (35%), Positives = 39/94 (41%), Gaps = 4/94 (4%)

Query: 422 SDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSS-SSSSSSSSSSSSSSSSSPSSS 480
           S S S  T S S  +     S S    S   S+SGSSS  SSSS+SSSS S S S     
Sbjct: 581 SSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGH 640

Query: 481 SGGESSETSSDLFEGSNEG---SSSSGSSGARRE 511
           +       S D       G   S  S   G+ R+
Sbjct: 641 NRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRD 674



 Score = 37.7 bits (86), Expect = 0.032
 Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 25/134 (18%)

Query: 112 TRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENN 171
           TRS  RG    RA ++T+              +R+  S +S + +  ++  S   +   +
Sbjct: 558 TRSRSRG----RARNKTSK-------------SRSRSSSSSSSSSSSTSSSSGSSSSSGS 600

Query: 172 SQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSP 231
           S  +  +  S STS   SR   +ST + +E   +R + R  +R   HRR+  R  R  S 
Sbjct: 601 SSSRSSSSSSSSTSGSSSRDSSSSTSSSSE-SRSRSRGRGHNRDRKHRRSVDRKRRDTSG 659

Query: 232 LHPMSEIPRRSHHS 245
           L        RSH S
Sbjct: 660 L-------ERSHKS 666



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 47/176 (26%), Positives = 73/176 (41%), Gaps = 17/176 (9%)

Query: 199 LTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNE 258
           LT  P ++ + + RSRS    R +    RSRS           S  S SS T      + 
Sbjct: 546 LTVHPESKSKTKTRSRSRGRARNKTSKSRSRS---------SSSSSSSSSSTSSSSGSSS 596

Query: 259 TEGSSRTRHHVTLRQQISGPEL--LSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRP 316
           + GSS +R   +     SG      S    ++S +R+ S+G G +       S    +R 
Sbjct: 597 SSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSV-DRKRR 655

Query: 317 PTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSER 372
            T  L+   +  + G    RD+  S+ ++       +++ ES R G R   SRSER
Sbjct: 656 DTSGLERSHKSSKGGS--SRDTKGSKDKNSRSDRKRSIS-ESSRSGKRS--SRSER 706



 Score = 30.0 bits (66), Expect = 6.7
 Identities = 32/145 (22%), Positives = 61/145 (42%), Gaps = 4/145 (2%)

Query: 78  QNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRF 137
           ++S  +    SS   S+G S     +S R + +++ S   G+ S  + S T+ +S     
Sbjct: 576 RSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSS-SSTSGSSSRDSSSSTSSSSESRSR 634

Query: 138 SLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTE 197
           S     NR+   + S +      R +SG    + S +   +  ++ +  + SRS+R  + 
Sbjct: 635 SRGRGHNRDRKHRRSVDRKR---RDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSI 691

Query: 198 ALTEVPPTRGQRRARSRSPDHRRTR 222
           + +     R  R  R R  D +  R
Sbjct: 692 SESSRSGKRSSRSERDRKSDRKDKR 716


>gi|150170725 zinc and ring finger 4 [Homo sapiens]
          Length = 429

 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 24/50 (48%), Positives = 37/50 (74%), Gaps = 2/50 (4%)

Query: 570 CSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSE--NSTCPICRRAVLAS 617
           C++C+ EY EG++L+ LPCSH YH  CID W S+    +CP+C+++V A+
Sbjct: 309 CAICLDEYEEGDQLKILPCSHTYHCKCIDPWFSQAPRRSCPVCKQSVAAT 358


>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
          Length = 2426

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 78/331 (23%), Positives = 133/331 (40%), Gaps = 37/331 (11%)

Query: 72   KEGPPPQNSDENRGGDSS--DDVSNGDSIIDWLNSVRQTGNTTRSGQRG----------- 118
            KE PPP        G S+  +D++  D +   L    +   + R+G  G           
Sbjct: 1706 KEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDR 1765

Query: 119  --------NQSWRAVSRTNPNSGDFRFSLEI---------NVNRNNGSQNSENENEPSAR 161
                    +   RA   ++    D+   +++         N NR+ G +  + ++   +R
Sbjct: 1766 SAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSR 1825

Query: 162  RSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDH-RR 220
                ++ E+ S+++    RS +   R S+S+ + ++  +     R +R +RSRS    RR
Sbjct: 1826 SKRSKSSEHKSRKRTSESRSRARK-RSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRR 1884

Query: 221  TRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPEL 280
            + ++ +R RSP H      R+   S S    +         S R+R H   R++ S   +
Sbjct: 1885 SVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRS-RSV 1943

Query: 281  LSRGLFAASGTRNASQGAGSSDTAASGESTGSGQ-RPPTIVLDLQVRRVRPGEYRQRDSI 339
              R  F+ S +R +   +  S T +    T S + R P+       RR R    R+R   
Sbjct: 1944 GRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRS 2003

Query: 340  ASRTRSRSQTPNNTVTYESERGGFRRTFSRS 370
              R RS S +P   V     R   RR FSRS
Sbjct: 2004 VVRRRSFSISP---VRLRRSRTPLRRRFSRS 2031



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 6/126 (4%)

Query: 112  TRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENN 171
            +R+  R ++S     R    S   R S  I+ +R + + +  +       R+        
Sbjct: 1922 SRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTP 1981

Query: 172  SQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQR------RARSRSPDHRRTRARA 225
            S+R     R   T +R  RS          + P R +R      R  SRSP  R+    +
Sbjct: 1982 SRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSS 2041

Query: 226  ERSRSP 231
            ER RSP
Sbjct: 2042 ERGRSP 2047


>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
          Length = 2303

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 78/331 (23%), Positives = 133/331 (40%), Gaps = 37/331 (11%)

Query: 72   KEGPPPQNSDENRGGDSS--DDVSNGDSIIDWLNSVRQTGNTTRSGQRG----------- 118
            KE PPP        G S+  +D++  D +   L    +   + R+G  G           
Sbjct: 1706 KEVPPPPKETLPDSGFSANIEDINEADLVRPLLPKDMERLTSLRAGIEGPLLASDVGRDR 1765

Query: 119  --------NQSWRAVSRTNPNSGDFRFSLEI---------NVNRNNGSQNSENENEPSAR 161
                    +   RA   ++    D+   +++         N NR+ G +  + ++   +R
Sbjct: 1766 SAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSR 1825

Query: 162  RSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDH-RR 220
                ++ E+ S+++    RS +   R S+S+ + ++  +     R +R +RSRS    RR
Sbjct: 1826 SKRSKSSEHKSRKRTSESRSRARK-RSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRR 1884

Query: 221  TRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPEL 280
            + ++ +R RSP H      R+   S S    +         S R+R H   R++ S   +
Sbjct: 1885 SVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRS-RSV 1943

Query: 281  LSRGLFAASGTRNASQGAGSSDTAASGESTGSGQ-RPPTIVLDLQVRRVRPGEYRQRDSI 339
              R  F+ S +R +   +  S T +    T S + R P+       RR R    R+R   
Sbjct: 1944 GRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRSRTPSRRRRSRS 2003

Query: 340  ASRTRSRSQTPNNTVTYESERGGFRRTFSRS 370
              R RS S +P   V     R   RR FSRS
Sbjct: 2004 VVRRRSFSISP---VRLRRSRTPLRRRFSRS 2031



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 31/126 (24%), Positives = 48/126 (38%), Gaps = 6/126 (4%)

Query: 112  TRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENN 171
            +R+  R ++S     R    S   R S  I+ +R + + +  +       R+        
Sbjct: 1922 SRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRRSRTPSRRSRTPSRRSRTPSRRSRTP 1981

Query: 172  SQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQR------RARSRSPDHRRTRARA 225
            S+R     R   T +R  RS          + P R +R      R  SRSP  R+    +
Sbjct: 1982 SRRSRTPSRRSRTPSRRRRSRSVVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRSS 2041

Query: 226  ERSRSP 231
            ER RSP
Sbjct: 2042 ERGRSP 2047


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 104/445 (23%), Positives = 164/445 (36%), Gaps = 57/445 (12%)

Query: 110  NTTRSGQ----RGNQSWRAVSRTNPNSGDFR------------FSLEINVNRNNGSQNSE 153
            +TT  G+    RG    R+ SRT  N    R             S   +++R++ +   +
Sbjct: 873  HTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQ 932

Query: 154  NENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARS 213
            +E   ++RR  G +V  +S  +  +  SE  S   SR+ R S +  +      G R  RS
Sbjct: 933  SEGSRTSRRQ-GSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQSR----HGSRHPRS 987

Query: 214  RSPDHRRTRARAERSRSPLHPMSEIPR-----RSHHSISSQTFEHPLVNETEGSSRTRHH 268
               D       A+ SR    P +E         SH    S   E       + +  +RH 
Sbjct: 988  HHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHS 1047

Query: 269  VTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRV 328
               R+Q S   +   G + +SG++ AS   G S+ + +   +G GQ  P      +  R 
Sbjct: 1048 GIPRRQASSA-VRDSGHWGSSGSQ-ASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARD 1105

Query: 329  RPG--------------EYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAG 374
              G               + Q +S   RTR+ +     +  +E  R   R + S+  +  
Sbjct: 1106 WSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGS-HHEQARDSSRHSASQEGQDT 1164

Query: 375  VRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTG--FGELSYFMYSDSDSEPTGSV 432
            +R +  +     RR    G     SV      R   +G      +    SD+    +GS 
Sbjct: 1165 IRAHPGS-----RRGGRQGSHHEQSVD-----RSGHSGSHHSHTTSQGRSDASHGQSGSR 1214

Query: 433  SNRNMERAESRSGRGG--SGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSS 490
            S     R + +SG G   SG      +S + SS  S      SS S +S   G S    S
Sbjct: 1215 SASRQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDS 1274

Query: 491  DLFEGSNEGSSSSGSSGARREGRHR 515
            D    S++    SGS+     G  R
Sbjct: 1275 DSERHSDDSERLSGSASRNHHGSSR 1299



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 113/488 (23%), Positives = 178/488 (36%), Gaps = 74/488 (15%)

Query: 93   SNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGD---------FRFSLEINV 143
            S+G S     ++  Q  +    GQ G++S    +R    SGD            S   ++
Sbjct: 3132 SSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADI 3191

Query: 144  NRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVP 203
            +R++ +   ++E    +RR  G +V  +S  +  +  SE  S   SR+ R S +  +   
Sbjct: 3192 SRHSQAVQGQSEGSRRSRRQ-GSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSR-- 3248

Query: 204  PTRGQRRARSRSPD-----HRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNE 258
               G R  RS   D     H   R+R   +R            SH    S   E      
Sbjct: 3249 --HGSRHPRSHHEDRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRH 3306

Query: 259  TEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPT 318
             + +  +RH    R Q S     SR  + +SG++ AS   G S+ + +   +G GQ  P 
Sbjct: 3307 QQSADSSRHSGIPRGQASSAVRDSRH-WGSSGSQ-ASDSEGHSEESDTQSVSGHGQAGPH 3364

Query: 319  IVLDLQVRRVRPG--------------EYRQRDSIASRTR-------------------- 344
                 +  R R G               + Q +S   RTR                    
Sbjct: 3365 QQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRH 3424

Query: 345  SRSQTPNNTVTYE---SERGG----FRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSET 397
            S SQ   +T+      S RG     + ++  RS  +G  ++ S      R   + G S +
Sbjct: 3425 SASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSG--SHHSHTTSQGRSDASRGQSGS 3482

Query: 398  TSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGS 457
             S + QT   +     G+ S   +S      T + S+R+     S+SG+G S G  +S  
Sbjct: 3483 RSASRQTRNDEQS---GDGSRHSWSHHHEASTQADSSRH-----SQSGQGQSAGPRTS-- 3532

Query: 458  SSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAP 517
             +  SS S  S S   S      SG  S        E S +GS    S    R G   + 
Sbjct: 3533 RNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAGHGHSA 3592

Query: 518  VTFDESGS 525
             +  +SG+
Sbjct: 3593 ESSRQSGT 3600



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 114/484 (23%), Positives = 173/484 (35%), Gaps = 79/484 (16%)

Query: 58   ESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVS-NGDSIIDWLNSVRQTGNTTRSGQ 116
            +S+     +  Q    G P  +    +G      V  +G S     ++  Q  +    GQ
Sbjct: 2124 DSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHHSHTTSQGRSDASRGQ 2183

Query: 117  RGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQV 176
             G++S    +     SGD         +R++GS + E  +   + R S      +S  + 
Sbjct: 2184 SGSRSASRKTYDKEQSGDG--------SRHSGSHHHEASSWADSSRHSLVGQGQSSGPRT 2235

Query: 177  ENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMS 236
              PR  S S + S SE +S ++         +RR+ S S +H  +     R  S  HP S
Sbjct: 2236 SRPRGSSVS-QDSDSEGHSEDS---------ERRSGSASRNHHGSAQEQSRDGSR-HPRS 2284

Query: 237  EIPRRSHHSISS----QTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTR 292
                R+ H  S+    Q+  H   N + G + + H     +  +G    S    +A  +R
Sbjct: 2285 HHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQA--RSSAGERHGSHHQQSADSSR 2342

Query: 293  NASQGAGSSDTAA--SGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQT- 349
            ++  G G + +A   SG    SG +                E    DS      +  Q  
Sbjct: 2343 HSGIGHGQASSAVRDSGHRGSSGSQ------------ASDSEGHSEDSDTQSVSAHGQAG 2390

Query: 350  PNNTVTYESERGGFRRTFSRSERAGVRTY-VSTIRIPIRRILNTGLSETTSVAIQTMLRQ 408
            P+     ES RG   R+  RS R+G   Y VST          TG S             
Sbjct: 2391 PHQQSHQESTRG---RSAGRSGRSGSFLYQVSTHEQSESAHGRTGTS------------- 2434

Query: 409  IMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGS--------SSS 460
              TG  + S+   +   S  + S      E  ++  G  GS  G   GS        S  
Sbjct: 2435 --TGGRQGSHHKQARDSSRHSTS-----QEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGH 2487

Query: 461  SSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTF 520
            S S  S ++S   S +    SG  S+   +   E S +GS  SGS        H A    
Sbjct: 2488 SGSHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSR------HHEASSRA 2541

Query: 521  DESG 524
            D SG
Sbjct: 2542 DSSG 2545



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 106/459 (23%), Positives = 161/459 (35%), Gaps = 82/459 (17%)

Query: 80   SDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSL 139
            SD +RG   S   S            RQT N  +SG     SW         S     S 
Sbjct: 3473 SDASRGQSGSRSAS------------RQTRNDEQSGDGSRHSW---------SHHHEAST 3511

Query: 140  EINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEAL 199
            + + +R++ S   ++   P   R+ G +V  +S  Q  +  SE  S   SR+ R S +  
Sbjct: 3512 QADSSRHSQSGQGQSAG-PRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQ 3570

Query: 200  TEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNET 259
            +      G R   S   D       AE SR            +HH+ +S   +    +E 
Sbjct: 3571 SR----DGSRHPTSHHEDRAGHGHSAESSRQS---------GTHHAENSSGGQAASSHEQ 3617

Query: 260  EGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAA--SGESTGSGQRPP 317
              SS    H +  QQ            +A  +R++  G G + +A   SG    SG +  
Sbjct: 3618 ARSSAGERHGSHHQQ------------SADSSRHSGIGHGQASSAVRDSGHRGSSGSQ-- 3663

Query: 318  TIVLDLQVRRVRPGEYRQRDSIASRTRSRSQT-PNNTVTYESERGGFRRTFSRSERAG-- 374
                          E    DS      +  Q  P+     ES RG   R+  RS R+G  
Sbjct: 3664 ----------ASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRG---RSAGRSGRSGSF 3710

Query: 375  ---VRTYVSTIRIPIRRILNTGLSE-TTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTG 430
               V T+  +     R   +TG  + +     +   R   +  G+ +   +  S     G
Sbjct: 3711 LYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRR---G 3767

Query: 431  SVSNRNMERAESRSGRGGS--------GGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSG 482
                   E++  RSG  GS        G   +S   S S S+S  + +   S   S  SG
Sbjct: 3768 GRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSG 3827

Query: 483  GESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFD 521
                E S+      +  S    S+G+RR  R  + V+ D
Sbjct: 3828 SRHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQD 3866



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 114/536 (21%), Positives = 197/536 (36%), Gaps = 68/536 (12%)

Query: 4   SDSNDKGSGDQSAAQRRSQMDRLDREEAFYQFVNNLSEEDYRLM---RDNNLLGTPGEST 60
           SD   +GS    A+      +  D +         L ++ ++     R     G  G S 
Sbjct: 410 SDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSL 469

Query: 61  EEELLRRLQQIKEGPPPQNSDENRGG--DSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRG 118
            +           G    ++   +G   + + D S   +  +  +++R    ++R G++G
Sbjct: 470 YQVSTHEQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQG 529

Query: 119 NQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSAR----RSSGENVENNSQR 174
           +   ++V+R+  +SG    S   +  R++ S         S +      SG+   ++  R
Sbjct: 530 SHHEQSVNRSG-HSGSHH-SHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSR 587

Query: 175 QVENPRSESTSARPS----------RSERNSTEALTEVPPTRG-----QRRARSRSPDHR 219
             E   S++ S+R S          R+ RN   ++++   ++G     +R + S S +H 
Sbjct: 588 HHE-ASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHH 646

Query: 220 RTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTR---HHVTLRQQIS 276
            +     R  S  HP S    R+ H  S+ +        T+ SS  +    H   R    
Sbjct: 647 GSAQEQSRDGSR-HPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAG 705

Query: 277 GPELLSRGLFAASGTRNASQGAGSSDTAA--SGESTGSGQRPPTIVLDLQVRRVRPGEYR 334
                   L +A  +R++  G G + +A   SG    SG +                E  
Sbjct: 706 ERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQ------------ATDSEGH 753

Query: 335 QRDSIASRTRSRSQTPNNTVTY-ESERGGFRRTFSRSERAGVRTY-VSTIRIPIRRILNT 392
             DS         Q  ++  ++ ES R    R+  RS R+G   Y VST +        T
Sbjct: 754 SEDSDTQSVSGHGQAGHHQQSHQESARD---RSGERSRRSGSFLYQVSTHKQSESSHGWT 810

Query: 393 GLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAE---SRSGRGGS 449
           G S               TG  + S+   +  +S  + S   ++  R     SR GR GS
Sbjct: 811 GPS---------------TGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGSSRRGRQGS 855

Query: 450 GGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGS 505
               S   S  S S  S ++S   S +    SG  S+  ++   E S +GS  SGS
Sbjct: 856 HHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGS 911



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 115/518 (22%), Positives = 186/518 (35%), Gaps = 65/518 (12%)

Query: 58   ESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDV-SNGDSIIDWLNSVRQTGNTTRSGQ 116
            +S+     +  Q    G P  +    +G      V S+G S     ++  Q  +    GQ
Sbjct: 1799 DSSRHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQ 1858

Query: 117  RGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQV 176
             G++S    +R    SGD             GS++S + +  ++ R+         Q Q 
Sbjct: 1859 SGSRSVSRQTRNEKQSGD-------------GSRHSGSRHHEASSRADSSRHSQVGQGQS 1905

Query: 177  ENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMS 236
              PR+ S +   S S+ + ++  +E      +R + S S +H  +     R  S  HP S
Sbjct: 1906 SGPRT-SRNQGSSVSQDSDSQGHSE----DSERWSGSASRNHLGSAWEQSRDGSR-HPGS 1959

Query: 237  EIPRRSHHSISSQTFEHPLVNETEGSSRTR---HHVTLRQQISGPELLSRGLFAASGTRN 293
                R+ H  S+ +        TE SSR +    H   R            L +A  +R+
Sbjct: 1960 HHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRH 2019

Query: 294  ASQGAGSSDTAA--SGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQT-P 350
            +  G G + +A   SG    SG +                E    DS      ++ +  P
Sbjct: 2020 SGIGHGQASSAVRDSGHRGYSGSQ------------ASDSEGHSEDSDTQSVSAQGKAGP 2067

Query: 351  NNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIM 410
            +     ES RG   ++   S R+G   Y         ++     SE+T            
Sbjct: 2068 HQQSHKESARG---QSGESSGRSGSFLY---------QVSTHEQSESTHGQSAPS----- 2110

Query: 411  TGFGELSYFMYSDSDSEPTGSVSNRNMERAE---SRSGRGGSGGGSSSGSSSSSSSSSSS 467
            TG  + S++  +   S  + S   ++  R     SR GR GS    S   S  S S  S 
Sbjct: 2111 TGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHHSH 2170

Query: 468  SSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGS-----SGARREGRHRAPVTFDE 522
            ++S   S +    SG  S+   +   E S +GS  SGS     S      RH        
Sbjct: 2171 TTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQS 2230

Query: 523  SGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLAMRS 560
            SG  P  S  +   +++D D +      E+    A R+
Sbjct: 2231 SG--PRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRN 2266



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 125/566 (22%), Positives = 207/566 (36%), Gaps = 80/566 (14%)

Query: 1   MENSDSNDKGSGDQSAAQRRSQM-DRLDREEAFYQFVNNLSEEDYRLMRDNNLL----GT 55
           +E  + N++G  D     R +Q   +      +Y   +   +    L+ +N +      +
Sbjct: 204 LEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSS 263

Query: 56  PGESTEEELLRRLQQIKEGPPPQNSDENRGGD--SSDDVSNGDSIIDWLNSVRQTGNTTR 113
            G+S+ +    R +   + P  ++    R G   S D  S G S     +S R +G+ +R
Sbjct: 264 DGKSSSQVNRSRHENTSQVPLQESRTRKRRGSRVSQDRDSEGHSE----DSERHSGSASR 319

Query: 114 S--GQRGNQSWRAVSRTNPNSGDFRFSL--EINVNRNNGSQNSENENE------------ 157
           +  G    QS R  SR   +  + R S     + +R +G++++E  +             
Sbjct: 320 NHHGSAWEQS-RDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQARS 378

Query: 158 -PSARRSSGENVENNSQRQVENPRSESTSARPSRSERNST-------EALTEVPPTR--- 206
            P  R  SG     +S R     R +++SA   R  R S+       E  +E   T+   
Sbjct: 379 SPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVS 438

Query: 207 GQRRARSRSPDHR-----RTRARAERSRSPLHPMS--EIPRRSHHSISSQTFEHPLVNET 259
           G  +A  R   H+     R+  R+ RS S L+ +S  E P  +H    + T      +  
Sbjct: 439 GHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSAHGRTGTSTGGRQGSHHE 498

Query: 260 EGSSRTRHHVTLRQQ--ISGPELLSRG-----LFAASGTRNASQGAGSSDTAASGESTGS 312
           +    +RH  +   Q  I G    SRG         S  R+   G+  S T + G S  S
Sbjct: 499 QARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDAS 558

Query: 313 GQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSER 372
             +  +     Q R         R S +    + SQ  ++     S+ G  + +  R+ R
Sbjct: 559 HGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSR---HSQVGQGQSSGPRTSR 615

Query: 373 AGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSV 432
                             N G S +     Q          G  S   +  S  E +   
Sbjct: 616 ------------------NQGSSVSQDSDSQGHSEDSERWSGSASR-NHHGSAQEQSRDG 656

Query: 433 SNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDL 492
           S       E R+G G S    SS  S +  + +SSS  ++SS   + SS GE   +   L
Sbjct: 657 SRHPRSHHEDRAGHGHSA--DSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQL 714

Query: 493 FEGSNEGSSSSG---SSGARREGRHR 515
               +   S +G   +S A R+  HR
Sbjct: 715 QSADSSRHSGTGHGQASSAVRDSGHR 740



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 101/487 (20%), Positives = 175/487 (35%), Gaps = 80/487 (16%)

Query: 58  ESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVS-NGDSIIDWLNSVRQTGNTTRSGQ 116
           +S+     +  Q    G P  +    +G      V+ +G S     ++  Q  +    GQ
Sbjct: 502 DSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGHSGSHHSHTTSQGRSDASHGQ 561

Query: 117 RGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENE----------------PSA 160
            G++S    +R    SGD          R++GS++ E  ++                P  
Sbjct: 562 SGSRSASRQTRNEEQSGDG--------TRHSGSRHHEASSQADSSRHSQVGQGQSSGPRT 613

Query: 161 RRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPD--- 217
            R+ G +V  +S  Q  +  SE  S   SR+   S +  +      G R  RS   D   
Sbjct: 614 SRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQEQSR----DGSRHPRSHHEDRAG 669

Query: 218 --HRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFE-HPLVNETEGSSRTRHHVTLRQQ 274
             H    +R   +R   +  S     SH    S   E H   ++ + +  +RH  T   Q
Sbjct: 670 HGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQ 729

Query: 275 ISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYR 334
            S   +   G   +SG++ A+   G S+ + +   +G GQ         +  R R GE  
Sbjct: 730 ASSA-VRDSGHRGSSGSQ-ATDSEGHSEDSDTQSVSGHGQAGHHQQSHQESARDRSGERS 787

Query: 335 QRDS-----IASRTRSRSQT----PNNTVT----YESERGGFRRTFSRSERAGVRTYVST 381
           +R       +++  +S S      P+  V     +E  R   R + S+  +  +R +  +
Sbjct: 788 RRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTIRGHPGS 847

Query: 382 IRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAE 441
            R   +                             S+   S   S  +GS  +    +  
Sbjct: 848 SRRGRQG----------------------------SHHEQSVDRSGHSGSHHSHTTSQGR 879

Query: 442 SRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSS 501
           S + RG SG  S+S ++ +   S   S  S S    +SS    S  + +   +G +EGS 
Sbjct: 880 SDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAG--QGQSEGSR 937

Query: 502 SSGSSGA 508
           +S   G+
Sbjct: 938 TSRRQGS 944



 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 103/466 (22%), Positives = 167/466 (35%), Gaps = 99/466 (21%)

Query: 69   QQIKEGPPPQNSDENRGGDSSDDVS-NGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSR 127
            Q    G P  +    +G      V  +G S     ++  Q  +    GQ G +S    +R
Sbjct: 1486 QDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTR 1545

Query: 128  TNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSAR 187
                SGD         +R++GS++    +EPS R  S         R  +  + ES  ++
Sbjct: 1546 NEEQSGDG--------SRHSGSRH----HEPSTRAGSS--------RHSQVGQGESAGSK 1585

Query: 188  PSRSERNST--EALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHS 245
             SR + +S   +  +E      +RR+ S S +H  + AR +      +P S    R+ H 
Sbjct: 1586 TSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGS-AREQSRHGSRNPRSHQEDRASHG 1644

Query: 246  ISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAA 305
             S+++         E SS  +   +  Q  S P           G R+ S+   S+D   
Sbjct: 1645 HSAESSRQSGTRHAETSSGGQAASSQEQARSSP-----------GERHGSRHQQSAD--- 1690

Query: 306  SGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQ-TPNNTVTYESERGGFR 364
            S   +G+G+R  + V+     R   G      S AS +   S+ +   +V+   + G  +
Sbjct: 1691 SSTDSGTGRRQDSSVVGDSGNRGSSG------SQASDSEGHSEESDTQSVSAHGQAGPHQ 1744

Query: 365  RTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDS 424
            ++   S R                    G S   S    + L Q+ T             
Sbjct: 1745 QSHQESTR--------------------GQSGERSGRSGSFLYQVSTH------------ 1772

Query: 425  DSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSS-----PSS 479
                         E++ES  GR G   G    S    +  SS  S+S          P S
Sbjct: 1773 -------------EQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGS 1819

Query: 480  SSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGS 525
            S GG         +E S + S  SGS  +    + R+ V+  +SGS
Sbjct: 1820 SRGGRQGSH----YEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGS 1861



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 87/415 (20%), Positives = 154/415 (37%), Gaps = 55/415 (13%)

Query: 114  SGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQ 173
            SG RG       S+ + N G    S   +V+ +  + + +  ++ SAR  SGE       
Sbjct: 2682 SGHRGYSG----SQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGET------ 2731

Query: 174  RQVENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPL- 232
                +  S S   + S  E++ +      P TRG++ +R          + ++  +  + 
Sbjct: 2732 ----SGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQDGQDTIR 2787

Query: 233  -HPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGT 291
             HP S    R       Q + H    ++ G S + H  T  Q   G    SRG    SG+
Sbjct: 2788 GHPGSSRGGR-------QGYHHEHSVDSSGHSGSHHSHTTSQ---GRSDASRG---QSGS 2834

Query: 292  RNASQGAGSSDTAASGES-TGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTP 350
            R+AS+   + + +  G   +GS     +   D+     R  +  Q  S  SR   RS+  
Sbjct: 2835 RSASRTTRNEEQSGDGSRHSGSRHHEASTHADIS----RHSQAVQGQSEGSR---RSRRQ 2887

Query: 351  NNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIR---------RILNTGLSETTSVA 401
             ++V+ +S+  G      R   +  R +  + +  +R         +    G   +   +
Sbjct: 2888 GSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSS 2947

Query: 402  IQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSS--- 458
             Q+  R   T  G  +   +  + S       + + + A+S S   G G G +S +    
Sbjct: 2948 RQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADS-SRHSGIGHGQASSAVRDS 3006

Query: 459  -----SSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGA 508
                 S S +S +   S  S +   S+ G   S   S           +SG SG+
Sbjct: 3007 GHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGS 3061



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 117/522 (22%), Positives = 187/522 (35%), Gaps = 74/522 (14%)

Query: 58   ESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVS-NGDSIIDWLNSVRQTGNTTRSGQ 116
            +S+     +  Q    G P  +S   +G      V  +G S     ++  Q  +    G 
Sbjct: 2448 DSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDASHGH 2507

Query: 117  RGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQV 176
             G++S    +R +  SGD             GS++S + +  ++ R+         Q Q 
Sbjct: 2508 SGSRSASRQTRNDEQSGD-------------GSRHSGSRHHEASSRADSSGHSQVGQGQS 2554

Query: 177  ENPRSE----STSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPL 232
            E PR+     S+ ++ S S+ +S ++         +R + S S +H  +     R  S  
Sbjct: 2555 EGPRTSRNWGSSFSQDSDSQGHSEDS---------ERWSGSASRNHHGSAQEQLRDGSR- 2604

Query: 233  HPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQIS--GPELLSRGLFAASG 290
            HP S    R+ H  S+ +        T+ SS  +   +  Q  S  G    S    +A  
Sbjct: 2605 HPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADS 2664

Query: 291  TRNASQGAGSSDTAA--SGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQ 348
            +R++  G G + +A   SG    SG +                E    DS      +  Q
Sbjct: 2665 SRHSGIGHGQASSAVRDSGHRGYSGSQ------------ASDNEGHSEDSDTQSVSAHGQ 2712

Query: 349  TPNNTVTY-ESERGGFRRTFSRSERAGVRTY-VSTIRIPIRRILNTGLSETTSVAIQTML 406
              ++  ++ ES RG   R+   S  +G   Y VST          TG S           
Sbjct: 2713 AGSHQQSHQESARG---RSGETSGHSGSFLYQVSTHEQSESSHGWTGPS----------- 2758

Query: 407  RQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGG---GSSSGSSSSSSS 463
                T   + S    +   S  + S   ++  R    S RGG  G     S  SS  S S
Sbjct: 2759 ----TRGRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGS 2814

Query: 464  SSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGS-----SGARREGRHRAPV 518
              S ++S   S +    SG  S+  ++   E S +GS  SGS     S      RH   V
Sbjct: 2815 HHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAV 2874

Query: 519  TFDESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLAMRS 560
                 GS    S  Q   +++D D +      E+    A R+
Sbjct: 2875 QGQSEGSR--RSRRQGSSVSQDSDSEGHSEDSERWSGSASRN 2914



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 95/435 (21%), Positives = 157/435 (36%), Gaps = 48/435 (11%)

Query: 93   SNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGD---------FRFSLEINV 143
            S+G S     ++  Q  +    GQ G++S    +R    SGD            S   ++
Sbjct: 2808 SSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADI 2867

Query: 144  NRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTEALTEVP 203
            +R++ +   ++E    +RR  G +V  +S  +  +  SE  S   SR+   S +      
Sbjct: 2868 SRHSQAVQGQSEGSRRSRRQ-GSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLR-- 2924

Query: 204  PTRGQRRARSRSPD-----HRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNE 258
               G R  RS   D     H    +R   +R            SH    S   E    + 
Sbjct: 2925 --DGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHH 2982

Query: 259  TEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPT 318
             + +  +RH      Q S   +   G    SG++ AS   G S+ + +   +  GQ    
Sbjct: 2983 QQSADSSRHSGIGHGQASSA-VRDSGHRGYSGSQ-ASDNEGHSEDSDTQSVSAHGQAGSH 3040

Query: 319  IVLDLQVRRVRPGEYRQRDS-----IASRTRSRSQTPNNTVTYESERGGFRRTFSRSERA 373
                 +  R R GE           +++  +S S   ++  T  S RG   R  SR E+A
Sbjct: 3041 QQSHQESARGRSGETSGHSGSFLYQVSTHEQSES---SHGWTGPSTRG---RQGSRHEQA 3094

Query: 374  GVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVS 433
               +  S  +            + T        R    G+    +  +S   S  +GS  
Sbjct: 3095 QDSSRHSASQY----------GQDTIRGHPGSSRGGRQGY----HHEHSVDSSGHSGSHH 3140

Query: 434  NRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLF 493
            +    +  S + RG SG  S+S ++ +   S  SS  S S    +S+    S    S   
Sbjct: 3141 SHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRH--SQAV 3198

Query: 494  EGSNEGSSSSGSSGA 508
            +G +EGS  S   G+
Sbjct: 3199 QGQSEGSRRSRRQGS 3213



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 106/490 (21%), Positives = 171/490 (34%), Gaps = 81/490 (16%)

Query: 77   PQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGD-- 134
            P+ S       S D  S G S     +S R++G+ +R+     Q        +P S    
Sbjct: 2233 PRTSRPRGSSVSQDSDSEGHSE----DSERRSGSASRNHHGSAQEQSRDGSRHPRSHHED 2288

Query: 135  -FRFSLEINVNRNNGSQNSENEN-------EPSARRSSGENVENNSQRQVENPRSE---- 182
                      +R +G+ ++EN +          AR S+GE   ++ Q+  ++ R      
Sbjct: 2289 RAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGH 2348

Query: 183  --------------STSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHR---RTRARA 225
                          S+ ++ S SE +S ++ T+     GQ     +S       R+  R+
Sbjct: 2349 GQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRS 2408

Query: 226  ERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGL 285
             RS S L+ +S     +H    S    H     + G  +  HH   R             
Sbjct: 2409 GRSGSFLYQVS-----THEQSESA---HGRTGTSTGGRQGSHHKQARDS----------- 2449

Query: 286  FAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYR-----QRDSIA 340
                 +R+++   G  DT      + SG R  +    L  R    G +      Q  S A
Sbjct: 2450 -----SRHSTSQEGQ-DTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDA 2503

Query: 341  SRTRSRSQTPNNTVTYESERG-GFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTS 399
            S   S S++ +     + + G G R + SR   A  R   S         +  G SE   
Sbjct: 2504 SHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSG-----HSQVGQGQSEGPR 2558

Query: 400  VAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSS 459
             +     R   + F + S       DSE     ++RN   +     R GS    S     
Sbjct: 2559 TS-----RNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDR 2613

Query: 460  SSSSSSSSSSSSSSSSSPSSSSGGE--SSETSSDLFEGSNEGSSSSGSSGARRE---GRH 514
            +    S+ SS  S +    +SSGG+  SS   +    G   GS    S+ + R    G  
Sbjct: 2614 AGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHG 2673

Query: 515  RAPVTFDESG 524
            +A     +SG
Sbjct: 2674 QASSAVRDSG 2683



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 111/498 (22%), Positives = 176/498 (35%), Gaps = 62/498 (12%)

Query: 81   DENRGGDSSDDVSNGDSIIDWLNSVR--QTGNTTRSGQRGNQ-SWRAVSRTNPNS--GDF 135
            D+  G  S    S       W +S R  Q G    SG R ++    +VS+ + +    D 
Sbjct: 1223 DKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDD 1282

Query: 136  RFSLEINVNRNNGSQNSENENEPSA--------RRSSGENVENNSQRQVENPRSES---- 183
               L  + +RN+   + E   + S         R S G + +++ Q    +  S S    
Sbjct: 1283 SERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQA 1342

Query: 184  ----TSARPSRSERNSTEALTEVPPTR----GQRRARS--RSPDHRR------TRARAER 227
                  AR S  ER+ +        +R    G R+A S  R   HR       T +    
Sbjct: 1343 VSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHS 1402

Query: 228  SRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRT-RHHVTLRQQI------SGPEL 280
              S    +S   +   H  S +        E+ G SR+  + V+  +Q       + P  
Sbjct: 1403 EDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQVSSHEQSESTHGQTAPST 1462

Query: 281  LSRGLFAASGTRNASQGAGSSD---TAASGESTGSGQRPPTIVLDLQVRRVRPGEYR--- 334
              R        RN+S+ + S D   T      +  G R  +       R    G +    
Sbjct: 1463 GGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSVDRSGHSGYHHSHT 1522

Query: 335  --QRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNT 392
              Q  S AS  +S  ++ +     E + G        S  +G R +  + R    R    
Sbjct: 1523 TPQGRSDASHGQSGPRSASRQTRNEEQSG------DGSRHSGSRHHEPSTRAGSSRHSQV 1576

Query: 393  GLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGG 452
            G  E  S   +T  RQ  +   +     +S+ DSE     ++RN   +     R GS   
Sbjct: 1577 GQGE--SAGSKTSRRQGSSVSQDRDSEGHSE-DSERRSESASRNHYGSAREQSRHGSRNP 1633

Query: 453  SSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGE--SSETSSDLFEGSNEGS---SSSGSSG 507
             S     +S   S+ SS  S +    +SSGG+  SS+  +    G   GS    S+ SS 
Sbjct: 1634 RSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSST 1693

Query: 508  ARREGRHRAPVTFDESGS 525
                GR +      +SG+
Sbjct: 1694 DSGTGRRQDSSVVGDSGN 1711



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 96/460 (20%), Positives = 166/460 (36%), Gaps = 64/460 (13%)

Query: 78   QNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRF 137
            ++   N      D  S+G S      S RQ+G        G Q+  +  +   + G+   
Sbjct: 1627 RHGSRNPRSHQEDRASHGHSA----ESSRQSGTRHAETSSGGQAASSQEQARSSPGE--- 1679

Query: 138  SLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARPSRSERNSTE 197
                     +GS++ ++ +  +    SG     +S    ++    S+ ++ S SE +S E
Sbjct: 1680 --------RHGSRHQQSADSST---DSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEE 1728

Query: 198  ALTEVPPTRGQRRARSRSPDHR---RTRARAERSRSPLHPMS--EIPRRSHHSISSQTFE 252
            + T+     GQ     +S       ++  R+ RS S L+ +S  E    +H      T  
Sbjct: 1729 SDTQSVSAHGQAGPHQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTGPSTGG 1788

Query: 253  HPLVNETEGSSRTRHHVTLRQQ--ISGPELLSRGLFAASGTRNASQGAGSSDTAASGEST 310
                   +    +RH  +   Q  I G    SRG           QG+    +  S   +
Sbjct: 1789 RQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRG---------GRQGSHYEQSVDSSGHS 1839

Query: 311  GSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERG-GFRRTFSR 369
            GS     T                Q  S  SR +S S++ +     E + G G R + SR
Sbjct: 1840 GSHHSHTT---------------SQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSR 1884

Query: 370  SERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPT 429
               A  R   S          ++ + +  S   +T   Q  +   +     +S+     +
Sbjct: 1885 HHEASSRADSSR---------HSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWS 1935

Query: 430  GSVSNRNMERAESRSGRGGSGGGS-----SSGSSSSSSSSSSSSSSSSSSSSPSSSSGGE 484
            GS S  ++  A  +S  G    GS     +    S+ SS  S +  + SSS   ++S  E
Sbjct: 1936 GSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHE 1995

Query: 485  SSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESG 524
             + +S+    GS+    S+ SS     G  +A     +SG
Sbjct: 1996 QARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSG 2035



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 107/486 (22%), Positives = 179/486 (36%), Gaps = 67/486 (13%)

Query: 73   EGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTT-----RSGQRGNQSWRAVSR 127
            EGP    +  +     SD   + +    W  S  +  + +     R G R  +S +    
Sbjct: 2555 EGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRA 2614

Query: 128  TNPNSGDF-RFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSES--- 183
             + +S D  R S   +   ++G Q + +  +  AR S+GE   ++ Q+  ++ R      
Sbjct: 2615 GHGHSADSSRQSGTRHTQTSSGGQAASSHEQ--ARSSAGERHGSHHQQSADSSRHSGIGH 2672

Query: 184  ---------------TSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERS 228
                           + ++ S +E +S ++ T+     GQ  A S    H+ + AR    
Sbjct: 2673 GQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQ--AGSHQQSHQES-ARGRSG 2729

Query: 229  RSPLHPMSEIPRRSHH--SISSQTFEHPLVNETEGSSRTRHHVTLRQQIS--GPELLSRG 284
             +  H  S + + S H  S SS  +  P     +GS   +   + R   S  G + + RG
Sbjct: 2730 ETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQDGQDTI-RG 2788

Query: 285  LFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTR 344
               +S  R   QG     +  S   +GS     T                Q  S ASR +
Sbjct: 2789 HPGSS--RGGRQGYHHEHSVDSSGHSGSHHSHTT---------------SQGRSDASRGQ 2831

Query: 345  SRSQTPNNTVTYESERG-GFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQ 403
            S S++ + T   E + G G R + SR   A     +S     ++     G SE +  +  
Sbjct: 2832 SGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQ-----GQSEGSRRS-- 2884

Query: 404  TMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSS 463
               R+  +   + S       DSE     ++RN   +     R GS    S     +   
Sbjct: 2885 ---RRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHG 2941

Query: 464  SSSSSSSSSSSSSPSSSSGGE--SSETSSDLFEGSNEGSSSSGSSGARRE---GRHRAPV 518
             S+ SS  S +    +SSGG+  SS   +    G   GS    S+ + R    G  +A  
Sbjct: 2942 HSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASS 3001

Query: 519  TFDESG 524
               +SG
Sbjct: 3002 AVRDSG 3007



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 108/513 (21%), Positives = 179/513 (34%), Gaps = 90/513 (17%)

Query: 59   STEEELLRRLQQIK---EGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQT--GNTTR 113
            ST  ++ R  Q ++   EG        +     SD   + +    W  S  +   G+   
Sbjct: 3186 STHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQE 3245

Query: 114  SGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENEN-------EPSARRSSGE 166
              + G++  R+        G        + +R +G++++E  +          AR S GE
Sbjct: 3246 QSRHGSRHPRSHHEDRAGHGH-----SADRSRQSGTRHAETSSGGQAASSHEQARSSPGE 3300

Query: 167  NVENNSQRQVEN------PRSESTSA------------RPSRSERNSTEALTEVPPTRGQ 208
               +  Q+  ++      PR +++SA            + S SE +S E+ T+     GQ
Sbjct: 3301 RHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQ 3360

Query: 209  RRARSRSPDHR---RTRARAERSRSPLHPMS--EIPRRSHHSISSQTFEHPLVNETEGSS 263
                 +S       R+  R+ RS S L+ +S  E    +H    + T      +  +   
Sbjct: 3361 AGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARD 3420

Query: 264  RTRHHVTLRQQ--ISG-PELLSRGL----FAASGTRNASQGAGSSDTAASGESTGSGQRP 316
             +RH  +   Q  I G P    RG     +  S  R+   G+  S T + G S  S    
Sbjct: 3421 SSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGHSGSHHSHTTSQGRSDAS---- 3476

Query: 317  PTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVR 376
                               R    SR+ SR QT N+    E    G R ++S    A  +
Sbjct: 3477 -------------------RGQSGSRSASR-QTRND----EQSGDGSRHSWSHHHEASTQ 3512

Query: 377  TYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRN 436
               S       R   +G  ++         R   +   + S       DSE     ++RN
Sbjct: 3513 ADSS-------RHSQSGQGQSAGPRTS---RNQGSSVSQDSDSQGHSEDSERWSGSASRN 3562

Query: 437  MERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGE--SSETSSDLFE 494
               +     R GS   +S     +    S+ SS  S +    +SSGG+  SS   +    
Sbjct: 3563 HRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSA 3622

Query: 495  GSNEGSSSSGSSGARRE---GRHRAPVTFDESG 524
            G   GS    S+ + R    G  +A     +SG
Sbjct: 3623 GERHGSHHQQSADSSRHSGIGHGQASSAVRDSG 3655



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 101/470 (21%), Positives = 153/470 (32%), Gaps = 112/470 (23%)

Query: 78  QNSDEN-RGGDSSDDVS--------NGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRT 128
           +N  EN R GD+   +S        N + + D+ N+ R T    +SG             
Sbjct: 185 KNKTENTRLGDNRKRLSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATY-------- 236

Query: 129 NPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTSARP 188
                   ++++        S   EN+    +R S G+     S  QV   R E+TS  P
Sbjct: 237 --------YTIQDEAYDTTDSLLEENKIYERSRSSDGK-----SSSQVNRSRHENTSQVP 283

Query: 189 SRSERNSTEALTEVPPTR--------GQRRARSRSPDHRRTRARAERSRSPLHPMSEIPR 240
            +  R      + V   R         +R + S S +H  +     R  S  HP S    
Sbjct: 284 LQESRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAWEQSRDGSR-HPRSHDED 342

Query: 241 RSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS 300
           R+ H  S+ +         E SSR +   +  Q  S P           G R+ S    S
Sbjct: 343 RASHGHSADSSRQSGTRHAETSSRGQTASSHEQARSSP-----------GERHGSGHQQS 391

Query: 301 SDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESER 360
           +D++    +TG GQ    +           G      S AS +   S+  +        +
Sbjct: 392 ADSSRHS-ATGRGQASSAVS--------DRGHRGSSGSQASDSEGHSENSDTQSVSGHGK 442

Query: 361 GGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFM 420
            G R+   +S +   R                G S   S    + L Q+ T         
Sbjct: 443 AGLRQ---QSHQESTR----------------GRSGERSGRSGSSLYQVSTH-------- 475

Query: 421 YSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSS---- 476
                            E+ +S  GR G+  G   GS    +  SS  S+S         
Sbjct: 476 -----------------EQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRG 518

Query: 477 -PSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRAPVTFDESGS 525
            P SS GG          E S   S  SGS  +    + R+  +  +SGS
Sbjct: 519 HPGSSRGGRQGSHH----EQSVNRSGHSGSHHSHTTSQGRSDASHGQSGS 564



 Score = 37.0 bits (84), Expect = 0.054
 Identities = 104/482 (21%), Positives = 166/482 (34%), Gaps = 72/482 (14%)

Query: 57   GESTEEELLRRLQQIKEGPP-PQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSG 115
            G ++   L    +Q ++G   P +  E+R G      S+  S        R T +++R G
Sbjct: 1936 GSASRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQS------GTRHTESSSR-G 1988

Query: 116  QRGNQSWRAVSRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQ 175
            Q  +   +A S      G        + +R++G  + +     SA R SG    + SQ  
Sbjct: 1989 QAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQAS---SAVRDSGHRGYSGSQ-- 2043

Query: 176  VENPRSESTSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPM 235
                     S     SE + T++++       Q +A      H+ + AR +   S     
Sbjct: 2044 --------ASDSEGHSEDSDTQSVS------AQGKAGPHQQSHKES-ARGQSGESSGRSG 2088

Query: 236  SEIPRRSHHSISSQTFEH--PLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASG--- 290
            S + + S H  S  T     P     +GS     H    Q  S       G     G   
Sbjct: 2089 SFLYQVSTHEQSESTHGQSAPSTGGRQGS-----HYDQAQDSSRHSASQEGQDTIRGHPG 2143

Query: 291  -TRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQT 349
             +R   QG+    +      +GS     T                Q  S ASR +S S++
Sbjct: 2144 PSRGGRQGSHQEQSVDRSGHSGSHHSHTT---------------SQGRSDASRGQSGSRS 2188

Query: 350  PNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSE--TTSVAIQTMLR 407
             +   TY+ E+ G     S S      ++  + R     ++  G S    TS    + + 
Sbjct: 2189 ASRK-TYDKEQSGDGSRHSGSHHHEASSWADSSR---HSLVGQGQSSGPRTSRPRGSSVS 2244

Query: 408  QIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSS 467
            Q     G          DSE     ++RN   +     R GS    S     +    S+ 
Sbjct: 2245 QDSDSEGH-------SEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAE 2297

Query: 468  SSSSSSSSSPSSSSGGE--SSETSSDLFEGSNEGSSSSGSSGARRE---GRHRAPVTFDE 522
            SS  S +    +SSGG+  SS   +    G   GS    S+ + R    G  +A     +
Sbjct: 2298 SSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRD 2357

Query: 523  SG 524
            SG
Sbjct: 2358 SG 2359



 Score = 32.0 bits (71), Expect = 1.8
 Identities = 96/496 (19%), Positives = 165/496 (33%), Gaps = 59/496 (11%)

Query: 74   GPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSG 133
            GP    +  +     SD   + +    W  S  +    +   Q  + S    S     +G
Sbjct: 3528 GPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAG 3587

Query: 134  DFRFSLEINVNRNNGSQNSENEN-------EPSARRSSGENVENNSQRQVENPRSE---- 182
                +     +R +G+ ++EN +          AR S+GE   ++ Q+  ++ R      
Sbjct: 3588 HGHSA---ESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGH 3644

Query: 183  --------------STSARPSRSERNSTEALTEVPPTRGQRRARSRSPDHR---RTRARA 225
                          S+ ++ S SE +S ++ T+     GQ     +S       R+  R+
Sbjct: 3645 GQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRS 3704

Query: 226  ERSRSPLHPMS--EIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQ--ISGPELL 281
             RS S L+ +S  E    +H      T         +    +RH  +   Q  I G    
Sbjct: 3705 GRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGS 3764

Query: 282  SRG-----LFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQR 336
             RG         S  R+   G+  S T + G S  S  +  +     + R         R
Sbjct: 3765 RRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSR 3824

Query: 337  DSIASRTRSRSQTPNN--TVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGL 394
             S +    + +Q  ++  + + + E  G RR  SR + + V     +   P     +   
Sbjct: 3825 HSGSRHHEASTQADSSRHSQSGQGESAGSRR--SRRQGSSVSQDSDSEAYPED---SERR 3879

Query: 395  SETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSS 454
            SE+ S       R+             S   S   GS         +S   +  S     
Sbjct: 3880 SESASRNHHGSSRE------------QSRDGSRHPGSSHRDTASHVQSSPVQSDSSTAKE 3927

Query: 455  SGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRH 514
             G  SS S  S+  S   S  SP SSS        ++  +G +      GS G+      
Sbjct: 3928 HGHFSSLSQDSAYHSGIQSRGSPHSSSSYHYQSEGTERQKGQSGLVWRHGSYGSADYDYG 3987

Query: 515  RAPVTFDESGSLPFLS 530
             +     + GS+ + S
Sbjct: 3988 ESGFRHSQHGSVSYNS 4003


>gi|29788758 ring finger protein 130 [Homo sapiens]
          Length = 419

 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 34/100 (34%), Positives = 50/100 (50%), Gaps = 7/100 (7%)

Query: 523 SGSLPFLSLAQFFLLNEDDDDQPR--GLTKEQIDNLAMRSFGENDA-----LKTCSVCIT 575
           S  L F  + +    N  D +Q R     K+ I  L  R+  + D         C+VCI 
Sbjct: 210 SAWLIFYFIQKIRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIE 269

Query: 576 EYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVL 615
            Y + + +R LPC H +H  C+D WLSE+ TCP+C+  +L
Sbjct: 270 SYKQNDVVRILPCKHVFHKSCVDPWLSEHCTCPMCKLNIL 309


>gi|150378447 zinc and ring finger 3 [Homo sapiens]
          Length = 836

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 21/55 (38%), Positives = 35/55 (63%)

Query: 570 CSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGNRESVV 624
           C++C+ +Y +G +LR +PC+H +H  C+D WL ++ TCP CR  ++      S V
Sbjct: 193 CAICLEKYIDGEELRVIPCTHRFHRKCVDPWLLQHHTCPHCRHNIIEQKGNPSAV 247


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 103/458 (22%), Positives = 177/458 (38%), Gaps = 59/458 (12%)

Query: 66  RRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAV 125
           RR  + K GPP +           +++S+  S  D  + +RQ G  T +     +    V
Sbjct: 89  RRSGRDKYGPPTRTEYRL----IVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGV 144

Query: 126 SRTNPNSGDFRFSLEINVNRNNGSQNSENENEPSARRSSGENVENNSQRQVENPRSESTS 185
                 S   R   +++    NG +    E++P +RR    +   +  R     RS S  
Sbjct: 145 IEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRS----RSRSRH 200

Query: 186 ARPSRSERNSTEALTEVPPTRGQR----RARSRSPDHRRTRARAERSRSPLHPMSEIPRR 241
           +R SRS   S+++      +R +     R++SRS    R+R++ E+SRSP    S    R
Sbjct: 201 SRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSR--SR 258

Query: 242 SHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQG---A 298
           SH               + G SR++      ++I   + + +   + S +R+ S+    +
Sbjct: 259 SH---------------SAGKSRSKSKDQAEEKIQNNDNVGKPK-SRSPSRHKSKSKSRS 302

Query: 299 GSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYES 358
            S +     E  GS  R  +     Q + +R    R R    SR+RSRS++ +     + 
Sbjct: 303 RSQERRVEEEKRGSVSRGRS-----QEKSLRQSRSRSRSKGGSRSRSRSRSKS-----KD 352

Query: 359 ERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSY 418
           +R G +R+   S         S  R    R    G    +        ++  T       
Sbjct: 353 KRKGRKRSREESRSR------SRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTD------ 400

Query: 419 FMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPS 478
                    P+ SVS +  E A+S S +    G S +  ++  + S S S+S S  + PS
Sbjct: 401 ---RSQSRSPSRSVS-KEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPS 456

Query: 479 SSSGGESSETSSDLFEGSNEGSSSSGSSGARREGRHRA 516
            S     S + +     S   S+S   S +R     R+
Sbjct: 457 ESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 78/333 (23%), Positives = 132/333 (39%), Gaps = 33/333 (9%)

Query: 56  PGESTEEELLRRLQQIKEGPPPQNSDENRGGDSSDDVSNGDSIIDWLNSVRQTGNTTRSG 115
           PG        R     +     ++S ++R    S   S+  S      S  ++G+ +RS 
Sbjct: 177 PGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKS-----RSRSRSGSRSRSK 231

Query: 116 QRGNQSWRAVSRTNPNSGDFRFSLEINVNRNN--GSQNSENENEPSARRSSGENVENNSQ 173
            R     R+ S+   +      S E + +R++  G   S+++++   +  + +NV     
Sbjct: 232 SRSRSQSRSRSKKEKSRSP---SKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKS 288

Query: 174 RQVENPRSESTSARPSRSERNSTEALTEVPPTRGQR------RARSRSPDHRRTRARAE- 226
           R     +S+S S   S+  R   E    V   R Q       R+RSRS    R+R+R+  
Sbjct: 289 RSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRS 348

Query: 227 --------RSRSPLHPMSEIPRRSHHSISSQTFEHPLVNETEGSSRTRHHVTLRQQISGP 278
                   R RS     S    RS  S  S+       ++   S + +   T R Q   P
Sbjct: 349 KSKDKRKGRKRSREESRSRSRSRS-KSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSP 407

Query: 279 -ELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPTIVLDLQVRRVRPGEYRQRD 337
              +S+    A    +  +G G S+ A + + T S  R      + + +   P E R R 
Sbjct: 408 SRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRS-----NSKSKPNLPSESRSRS 462

Query: 338 SIASRTRSRSQTPNNTVTYESERGGFRRTFSRS 370
             AS+TRSRS++ + + +    R    R+ SRS
Sbjct: 463 KSASKTRSRSKSRSRSASRSPSRSR-SRSHSRS 494



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/333 (23%), Positives = 121/333 (36%), Gaps = 53/333 (15%)

Query: 199 LTEVPPTRGQRRARSRSPDHRRTRARAERSRSPLHPMSEIPRRSHHSISSQTFEHPLVNE 258
           L E  P   +RR+ SRS  H R+R+R+  SR          +    S SS++      + 
Sbjct: 172 LVEDKPGSRRRRSYSRSRSHSRSRSRSRHSR----------KSRSRSGSSKSSHSKSRSR 221

Query: 259 TEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGSSDTAASGESTGSGQRPPT 318
           +   SR+R     R Q       SR       +R+ S+    S + ++G+S    +    
Sbjct: 222 SRSGSRSRSKSRSRSQ-------SRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAE 274

Query: 319 IVLDLQVRRVRPGEYRQRDSIASRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTY 378
             +       +P + R      S+++SRS++    V  E +RG   R   RS+   +R  
Sbjct: 275 EKIQNNDNVGKP-KSRSPSRHKSKSKSRSRSQERRVE-EEKRGSVSR--GRSQEKSLRQS 330

Query: 379 VSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYSDSDSEPTGSVSNRNME 438
            S  R       + G S + S +                    S S  +  G   +R   
Sbjct: 331 RSRSR-------SKGGSRSRSRS-------------------RSKSKDKRKGRKRSREES 364

Query: 439 RAESRSG----RGGSGGGSSSGSSSSSSSSSSSSSSSSSSSSPSSSSGGESSETSSDLFE 494
           R+ SRS     R    G      + SS       +  S S SPS S   E     S+   
Sbjct: 365 RSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSE--S 422

Query: 495 GSNEGSSSSGSSGARREGRHRAPVTFDESGSLP 527
              EG   S ++G  +E R R+        +LP
Sbjct: 423 SQREGRGESENAGTNQETRSRSRSNSKSKPNLP 455


>gi|37595553 ring finger protein 111 [Homo sapiens]
          Length = 986

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 25/60 (41%), Positives = 36/60 (60%)

Query: 563 ENDALKTCSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVLASGNRES 622
           E D  + C++C++   EG  +R+LPC H +H  C+D+WL  N  CPICR  + A    ES
Sbjct: 927 EEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES 986



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 85/393 (21%), Positives = 152/393 (38%), Gaps = 91/393 (23%)

Query: 144 NRNNGSQNSENENEPSARRSSGEN--VENNSQRQVE--------NPRSESTSARPSRSER 193
           + +N S  S+  + PS+    G++  V ++  ++V         N +S S SAR  +  R
Sbjct: 127 DEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSARSHKWPR 186

Query: 194 NSTEALTEV----PPTRGQ-------RRARSRSPDHRRTRARAERSRSPLHPMSEIPRRS 242
             TE+++ +    P   G        R+   ++   +RT+ + ER          + RR 
Sbjct: 187 TETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRK 246

Query: 243 HHSI--SSQTFEHPLVNETEGSSRTRHHVTLRQQISGPELLSRGLFAASGTRNASQGAGS 300
           +  +  SS + E+ L +E+  SS T     L    S            +   N +  +GS
Sbjct: 247 YALLPSSSSSSENDLSSESSSSSSTEGEEDLFVSAS-----------ENHQNNPAVPSGS 295

Query: 301 SDT------AASGESTGSGQRPPTIVLDLQVRRVRPGE-YRQRDSIASRTRSRSQTPNNT 353
            D       A+S     + +       D +V  V  GE YR R ++     SRS     +
Sbjct: 296 IDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLG---HSRSHWSQGS 352

Query: 354 VTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGF 413
            ++ S          R +    R+ +ST+  P+R+      +E   + +           
Sbjct: 353 SSHAS----------RPQEPRNRSRISTVIQPLRQ----NAAEVVDLTVD---------- 388

Query: 414 GELSYFMYSDSDSEPTGSVSNRNMERAESRSGRGGSGGGSSSGSSSSSSSSSSSSSSSSS 473
                      + EPT  V      R ES++          + +S ++S+ S+S  +S +
Sbjct: 389 -----------EDEPT--VVPTTSARMESQA----------TSASINNSNPSTSEQASDT 425

Query: 474 SSSPSSSSGGESSETSSDLFEGSNEGSSSSGSS 506
           +S+ +SS     SETS+ L   S  G+S    S
Sbjct: 426 ASAVTSSQPSTVSETSATLTSNSTTGTSIGDDS 458


>gi|58331204 ring finger protein 150 [Homo sapiens]
          Length = 438

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 32/97 (32%), Positives = 49/97 (50%), Gaps = 7/97 (7%)

Query: 526 LPFLSLAQFFLLNEDDDDQPR--GLTKEQIDNLAMRSFGENDA-----LKTCSVCITEYT 578
           L F  + +F   N  D +Q R     K+ I  L +R+  + D         C+VCI  Y 
Sbjct: 227 LVFYYIQRFRYANARDRNQRRLGDAAKKAISKLQIRTIKKGDKETESDFDNCAVCIEGYK 286

Query: 579 EGNKLRKLPCSHEYHVHCIDRWLSENSTCPICRRAVL 615
             + +R LPC H +H  C+D WL ++ TCP+C+  +L
Sbjct: 287 PNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNIL 323


>gi|56711322 ring finger protein 43 [Homo sapiens]
          Length = 783

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 19/41 (46%), Positives = 32/41 (78%)

Query: 570 CSVCITEYTEGNKLRKLPCSHEYHVHCIDRWLSENSTCPIC 610
           C++C+ E++EG +LR + C HE+H +C+D WL ++ TCP+C
Sbjct: 272 CAICLEEFSEGQELRVISCLHEFHRNCVDPWLHQHRTCPLC 312


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.123    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,930,366
Number of Sequences: 37866
Number of extensions: 1242595
Number of successful extensions: 37895
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 783
Number of HSP's successfully gapped in prelim test: 562
Number of HSP's that attempted gapping in prelim test: 15137
Number of HSP's gapped (non-prelim): 11217
length of query: 624
length of database: 18,247,518
effective HSP length: 108
effective length of query: 516
effective length of database: 14,157,990
effective search space: 7305522840
effective search space used: 7305522840
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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