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Search of human proteins with 33667040
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33667040 NLR family, pyrin domain containing 8 [Homo
sapiens]
(1048 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 2153 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 620 e-177
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 499 e-141
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 477 e-134
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 465 e-131
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 463 e-130
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 460 e-129
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 441 e-123
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 436 e-122
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 435 e-121
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 435 e-121
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 427 e-119
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 417 e-116
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 399 e-110
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 397 e-110
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 362 1e-99
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 348 2e-95
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 281 2e-75
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 281 2e-75
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 281 2e-75
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 281 2e-75
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 281 2e-75
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 212 1e-54
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 181 4e-45
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 161 3e-39
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 161 3e-39
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 161 3e-39
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 161 3e-39
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 161 3e-39
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 161 3e-39
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 2153 bits (5578), Expect = 0.0
Identities = 1048/1048 (100%), Positives = 1048/1048 (100%)
Query: 1 MSDVNPPSDTPIPFSSSSTHSSHIPPWTFSCYPGSPCENGVMLYMRNVSHEELQRFKQLL 60
MSDVNPPSDTPIPFSSSSTHSSHIPPWTFSCYPGSPCENGVMLYMRNVSHEELQRFKQLL
Sbjct: 1 MSDVNPPSDTPIPFSSSSTHSSHIPPWTFSCYPGSPCENGVMLYMRNVSHEELQRFKQLL 60
Query: 61 LTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRRE 120
LTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRRE
Sbjct: 61 LTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRRE 120
Query: 121 INAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQ 180
INAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQ
Sbjct: 121 INAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQ 180
Query: 181 GVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCA 240
GVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCA
Sbjct: 181 GVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCA 240
Query: 241 FYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLE 300
FYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLE
Sbjct: 241 FYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLE 300
Query: 301 DLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTM 360
DLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTM
Sbjct: 301 DLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTM 360
Query: 361 EKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSC 420
EKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSC
Sbjct: 361 EKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSC 420
Query: 421 PNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLD 480
PNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLD
Sbjct: 421 PNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLD 480
Query: 481 QTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQR 540
QTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQR
Sbjct: 481 QTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQR 540
Query: 541 LIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPP 600
LIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPP
Sbjct: 541 LIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPP 600
Query: 601 SPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVEL 660
SPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVEL
Sbjct: 601 SPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVEL 660
Query: 661 TVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFL 720
TVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFL
Sbjct: 661 TVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFL 720
Query: 721 KALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLC 780
KALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLC
Sbjct: 721 KALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLC 780
Query: 781 RVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ 840
RVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ
Sbjct: 781 RVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ 840
Query: 841 LERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQR 900
LERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQR
Sbjct: 841 LERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQR 900
Query: 901 LVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
LVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL
Sbjct: 901 LVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
Query: 961 ENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVIFCIPA 1020
ENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVIFCIPA
Sbjct: 961 ENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVIFCIPA 1020
Query: 1021 WTRITSFSPTPHPPDFTGKSDCLSQINP 1048
WTRITSFSPTPHPPDFTGKSDCLSQINP
Sbjct: 1021 WTRITSFSPTPHPPDFTGKSDCLSQINP 1048
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 620 bits (1600), Expect = e-177
Identities = 361/971 (37%), Positives = 540/971 (55%), Gaps = 10/971 (1%)
Query: 40 GVMLYMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
G++LY+ ++ EEL FK L + W++V+ A ++ +L+ + +PG +AW
Sbjct: 14 GLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWS 73
Query: 100 VTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVME 159
V+ IF MN +C + EIN T+ P+D GETQ + +E G Y++ + E
Sbjct: 74 VSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQED-QEAVLGDGTEYRNRIKE 132
Query: 160 KFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTIL 219
KF WD + G DF + + + L L G QP+ V +QGA G+GKT L
Sbjct: 133 KFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTL 192
Query: 220 AKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPD 279
+K M +WA Y + FY + +E+NQ ++SF++LI + WP ++ + +IM +P
Sbjct: 193 VRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPS 252
Query: 280 QLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSW 339
LL ++D F+EL + L EDW Q+ P S L+SSLL K MLPEA+LL+ R T+
Sbjct: 253 SLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTS 312
Query: 340 QTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVC 399
+ K LLK V L G + + +Y +F +V S N +LFSMC+VP+VC
Sbjct: 313 KRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVC 372
Query: 400 WMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAA 459
W C+ LKQQME+G ++T +C T++F YISSLF +QAQL LC +AA
Sbjct: 373 WAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAA 432
Query: 460 DSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFY 519
+W +V +E+L L Q+ V++F+ +I+++ A E+ YVFT + QEFFAA+FY
Sbjct: 433 KGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFY 492
Query: 520 VLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKV 579
+L N +++ L+ S +L+ M FLFG LNE +E++F CK+
Sbjct: 493 MLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKM 552
Query: 580 SFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNN 639
S K KLL+ + +L D G +LF+CL+E +++AF+SQA+ + KV + I
Sbjct: 553 SLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEK 612
Query: 640 KEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVF 699
+ VS+FCLK C+ L + L+VT+ F K+ +S P + + + + WQDLCSV
Sbjct: 613 IHLLVSSFCLKHCRCLRTIRLSVTVVFEK--KILKTSLP-TNTWDGDRITHCWQDLCSVL 669
Query: 700 ATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQ 759
TN+ L L + +S L + L LRHP CKLQKLLL+ + QD+ L N+
Sbjct: 670 HTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNK 729
Query: 760 HLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLK 819
+L +L+++ ++ VK LC L+ P C+LQ LRLE C T ++ N L + L
Sbjct: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
Query: 820 TLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLS 873
L L N+L + G L A LERLS+E+C LT+ CE L+ L +K LTHL
Sbjct: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
Query: 874 LAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSF 933
LA+N L D G K + +AL H +C L+ LVLR+C T + + ++L NK+L LDL
Sbjct: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
Query: 934 NSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAI 993
N L+D+GV LLC+ ++P C LQ LEL C+ T+ CC +AS++ N +LR LDL N +
Sbjct: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
Query: 994 GVYGILTLCEA 1004
G+ LC+A
Sbjct: 970 QDDGVKILCDA 980
Score = 97.1 bits (240), Expect = 8e-20
Identities = 59/154 (38%), Positives = 87/154 (56%), Gaps = 3/154 (1%)
Query: 857 ESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF-NCCQD 915
+ L S L ++ L L L + L + + L H C LQ+L+L+ +TF + CQD
Sbjct: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKF--ITFPDGCQD 720
Query: 916 MISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMAS 975
+ ++L NK L LDL + + D+GV LCEALK+P+C LQ L LE+C T CC +++
Sbjct: 721 ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISN 780
Query: 976 MLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQK 1009
L ++Q L L+LS N + G+ LCEA K
Sbjct: 781 ALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPK 814
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 499 bits (1286), Expect = e-141
Identities = 308/974 (31%), Positives = 507/974 (52%), Gaps = 52/974 (5%)
Query: 40 GVMLYMRNVSHEELQRFKQLLLTELSTGTM-PITWDQVETASWAEVVHLLIERFPGRRAW 98
G++ Y++ + EE +FK+LL L + PI W +++ AS +V LL + +PG++AW
Sbjct: 10 GLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAW 69
Query: 99 DVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVM 158
+VT N+F +N + + E+ K+ Y+ ++
Sbjct: 70 EVTLNLFLQINRKDLWTKAQEEMR-------------------------NKLNPYRKHMK 104
Query: 159 EKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTI 218
E F IW+ T F+ + + + L + TV ++G GIGKT
Sbjct: 105 ETFQLIWEKETCLHVPEHFYKETMKNEYKELN----DAYTAAARRHTVVLEGPDGIGKTT 160
Query: 219 LAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKP 278
L +KVM +WA + + F+ + E+N + S EL+ + WP S + + I S+P
Sbjct: 161 LLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQP 220
Query: 279 DQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTS 338
+++L ++DGFE+L L DLS+DWRQ+ P ++LSSLL K MLPE++LLI + +
Sbjct: 221 ERILFIMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLA 279
Query: 339 WQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVV 398
Q +L+ P L+ L GF+ EK YF +FG + +V +F +N LF +C P
Sbjct: 280 MQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFT 339
Query: 399 CWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLA 458
CW+VC+ +KQ++ERG +L + N T ++ +++++F +++F K+++A+L+ LC LA
Sbjct: 340 CWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALA 399
Query: 459 ADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALF 518
A+ +W +V DL L ++ ++GM +L+R D + F + QEF AA+F
Sbjct: 400 AEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMF 456
Query: 519 YVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCK 578
Y+L P+ N + S + R AS ++ L+ +G+F+FG E S +E SF
Sbjct: 457 YLLKRPKDDPNPAIGSITQLVR--ASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFP 514
Query: 579 VSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGN 638
+S K+++ + + L +C+ +LF L E +E+ FV++ +N + +V + IGN
Sbjct: 515 LSKDLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGN 574
Query: 639 NKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSV 698
+ + +++FCLK CQ+L + + V N++ S + N +W++LCS+
Sbjct: 575 IEHLVIASFCLKHCQHLTTLRMCVE----NIFPDDSGC-----ISDYNEKLVYWRELCSM 625
Query: 699 FATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGN 758
F TN ++L M N+ L P L L AL P CKL+KL+ V + +L + N
Sbjct: 626 FITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGH-DSELFKAVLHN 684
Query: 759 QHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHL 818
HL+ L + + ++ LC L+ P C+++ L L C + + D+ + L N L
Sbjct: 685 PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKL 744
Query: 819 KTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHL 872
K L L +N L + C A S LERL + C LT ++C+S++ L SK L+ L
Sbjct: 745 KHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLL 804
Query: 873 SLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLS 932
L NAL+D G + AL H C ++ L L C LT + C+D+ + L N LK+L L
Sbjct: 805 DLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLG 864
Query: 933 FNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNA 992
N + D GV LC AL++P C L+ L L+ C T CC +A+ L + LR L+L A
Sbjct: 865 HNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIA 924
Query: 993 IGVYGILTLCEAFS 1006
+ ++ LCEA S
Sbjct: 925 LDADAVVVLCEALS 938
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 477 bits (1227), Expect = e-134
Identities = 312/973 (32%), Positives = 495/973 (50%), Gaps = 46/973 (4%)
Query: 40 GVMLYMRNVSHEELQRFKQ-LLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAW 98
G+M Y+ + EE ++FK+ L L I W +V+ AS E+ +LLI+ + ++AW
Sbjct: 10 GLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAW 69
Query: 99 DVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVM 158
++T IF M+ +C+ V RE +G + Y+++
Sbjct: 70 NITLRIFQKMDRKDLCMKVMRE-------------------------RTGYTKTYQAHAK 104
Query: 159 EKFFPIWDITTWPGNQRDFFYQGVHRHE-EYLPCLLLPKRPQGRQPKTVAIQGAPGIGKT 217
+KF +W + +F + V + E ++L L PK G+QP+TV IQG GIGKT
Sbjct: 105 QKFSRLWSSKSVTEIHL-YFEEEVKQEECDHLDRLFAPKEA-GKQPRTVIIQGPQGIGKT 162
Query: 218 ILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSK 277
L K+M W+ NK + + FYF C+E+ + S ++LI ++WP +++I+S+
Sbjct: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
Query: 278 PDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFT 337
P++LL ++D FEEL L + DL D +K P VLLSSLL K MLPEA+LLI I+
Sbjct: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
Query: 338 SWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPV 397
+ + + + GFN +++ YF +F + + + E+ LFS+C++P+
Sbjct: 283 CPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPL 342
Query: 398 VCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHL 457
+CW++C+ LKQ+M++G +L +C + TSV+ ++ +LF Q QL+ LC L
Sbjct: 343 LCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSL 402
Query: 458 AADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAAL 517
AA+ MW + ++DL + + A LG IL + E YVF V QEF AAL
Sbjct: 403 AAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAAL 462
Query: 518 FYVLCFPQRLKNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQ 576
FY+L L + H + L+A+ + +++ +G FL G LN+ ++ F
Sbjct: 463 FYLL--KSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFG 520
Query: 577 CKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRI 636
++S K+++ + + L + P +FYCL E+++ AFV QA+N + I
Sbjct: 521 FQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHI 580
Query: 637 GNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLC 696
+N ++ VSA+CLK C L ++ +V F + SS+S W +C
Sbjct: 581 IDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLIC---------WHHIC 631
Query: 697 SVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLT 756
SV T+ L L + +S L LRHP C+LQKL + V+ + + L VL
Sbjct: 632 SVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLF 691
Query: 757 GNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNG 816
L+YL ++ ++ LC L P ++ L L +C +P L L N
Sbjct: 692 YQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNK 751
Query: 817 HLKTLILRKNSLEN-----CGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
L L + N L+ C A L L + C+L++ CE ++ L ++K + +
Sbjct: 752 KLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRY 811
Query: 872 LSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDL 931
L L+ N LKDEG K + AL H C L L L KC +T C+D+ SAL N+ LK L +
Sbjct: 812 LDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQI 871
Query: 932 SFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKN 991
N + D GV LLC AL + DC L+IL LE C TS CC+ +AS+L ++ L+ L+L+ N
Sbjct: 872 GCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLN 931
Query: 992 AIGVYGILTLCEA 1004
+ G++ LCEA
Sbjct: 932 TLDHTGVVVLCEA 944
Score = 139 bits (351), Expect = 1e-32
Identities = 92/270 (34%), Positives = 141/270 (52%), Gaps = 6/270 (2%)
Query: 751 LIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPR---IWTD 807
+ VLT + HLR L++Q + C LR P CRLQ L + + + + ++
Sbjct: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEV 689
Query: 808 L--GNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQ 865
L +L+ T + R + C A ++ L++ NC+L+ + CE LA L
Sbjct: 690 LFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTN 749
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
+K LT+L+++ N L D G + AL L L+L C L+ CC+ + L +NK+
Sbjct: 750 NKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKS 808
Query: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRH 985
++ LDLS N LKD+G+ LCEALK+PDC L L L C T+ C+ +AS L NQ+L+
Sbjct: 809 VRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKI 868
Query: 986 LDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
L + N IG G+ LC A + R E++
Sbjct: 869 LQIGCNEIGDVGVQLLCRALTHTDCRLEIL 898
Score = 38.1 bits (87), Expect = 0.044
Identities = 22/60 (36%), Positives = 32/60 (53%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
+DL SV + L+ L +T + L + L ALRHP+C LQ L LR+ + Q L+
Sbjct: 911 KDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALL 970
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 465 bits (1197), Expect = e-131
Identities = 335/1061 (31%), Positives = 497/1061 (46%), Gaps = 113/1061 (10%)
Query: 33 PGSPCENGVMLYMRNVSHEELQRFKQLLLTE-------LSTGTMP-ITWDQVETASWAEV 84
P G++ Y+ + +L+ FK L + G P I W + A +
Sbjct: 9 PNGGTNQGLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNL 68
Query: 85 VHLLIERFPGRRAWDVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLE- 143
LL E FP +AW V IF MN +C VR E+ + T E +D TQ +LE
Sbjct: 69 SFLLDEHFPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQD----PTQEDLEM 124
Query: 144 ------------------------EGESGKI----------------------RRYKSNV 157
E E+G + R+Y+ N+
Sbjct: 125 LEAAAGNMQTQGCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENM 184
Query: 158 MEKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKT 217
+ WD +WP + HEE L LL P R + Q +T+ + G G+GKT
Sbjct: 185 KAELLETWDNISWPKDHVYIRNTSKDEHEE-LQRLLDPNRTRA-QAQTIVLVGRAGVGKT 242
Query: 218 ILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSK 277
LA + M WA + + FY C ++ + +F+ELI WP + + MS+
Sbjct: 243 TLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQ 302
Query: 278 PDQLLLLLDGFEEL--TSTLIDRLEDLSE--DWRQKLPGSVLLSSLLSKTMLPEATLLIM 333
P++LL ++DGFEE+ + + + L+D S DW Q+LP + +L SLL K ++P ATLLI
Sbjct: 303 PEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLIT 362
Query: 334 IRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMC 393
I+ + K L P V + GF + YF +F + E +++L +N LF C
Sbjct: 363 IKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSC 422
Query: 394 RVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEG 453
P+VCW VCS LKQ R +L TS++ + S+LF T + + Q
Sbjct: 423 SAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRA 482
Query: 454 LCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEF 513
LC LA + +W + KED E L+ + + +IL++I FT ++FQEF
Sbjct: 483 LCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEF 542
Query: 514 FAALFYVL----------CFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFL 563
FAA+ +VL PQ +K +L HV + + ++Y + + LF FG L
Sbjct: 543 FAAMSFVLEEPREFPPHSTKPQEMK--MLLQHVLLDK--------EAYWTPVVLFFFGLL 592
Query: 564 NEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVS 623
N+ A +E + CK+S +LLK L K + S + +LF+CLHE +EE F
Sbjct: 593 NKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTK 652
Query: 624 QALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVT-------LNFMNVWKLSSSS 676
+ L +V L I ++E+Q S+FCLK C+ L+++ L+V+ L + K S
Sbjct: 653 KMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRM 712
Query: 677 HPGSEAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQK 736
H W +CS TN+ L L ++NS L +K L AL++P+CK+QK
Sbjct: 713 HA-------------WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
Query: 737 LLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLE 796
L + V + QDLI L GN L +L ++ V L+ + LR C L+ L LE
Sbjct: 760 LTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKL-GMTVPLILKALRHSACNLKYLCLE 818
Query: 797 DCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCN 850
C + DL L H+ L L N L++ G L A LERL + C
Sbjct: 819 KCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQ 878
Query: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
L C+ L+ L Q++ LTHL+L++N+L+DEG K + AL LQ L L C T
Sbjct: 879 LAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTR 938
Query: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
C ++ +AL N +K LDL N L+DDGV LLCEALK P L L L C T+ CC
Sbjct: 939 EGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACC 997
Query: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKR 1011
Q + S+L ++ L +L+L N + G+ LC+A R
Sbjct: 998 QHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCR 1038
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 463 bits (1191), Expect = e-130
Identities = 336/1018 (33%), Positives = 509/1018 (50%), Gaps = 65/1018 (6%)
Query: 44 YMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103
Y+ + EL++FK L T G I W +E A E+ LLI F AW + +
Sbjct: 16 YLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRLALS 75
Query: 104 IFAIMNCDKMCVVVRRE-----------------------INAILPTLEPEDL--NVGET 138
F +N + +RE ++ + P +P++ +
Sbjct: 76 TFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRR 135
Query: 139 QVNLEEGESGKI-------RRYK--------SNVMEKFFPIWDITTWPGNQRDFFYQGVH 183
+ L E + ++ RY SN M+ + D T G+ R +Q
Sbjct: 136 KFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLD--TGRGHARTVGHQASP 193
Query: 184 RHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYF 243
E L P + P+TV +QGA GIGK++LA KVM +WA K + + FY
Sbjct: 194 IKIE---TLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYI 250
Query: 244 HCQEVNQT-TDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDL 302
+C+E+NQ+ T+ S +LI WP + +++ P++LL ++DGF+EL + D
Sbjct: 251 NCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPW 310
Query: 303 SEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEK 362
W +K P +LL+SL+ K +LPE +LLI R T+ + LL+ P V + GF+ E+
Sbjct: 311 CLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAER 370
Query: 363 IKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPN 422
+YF YF + E+ QV ++ +N LF+MC VP+VCW+VC+ L+QQ+E G L Q+
Sbjct: 371 KEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRT 430
Query: 423 ATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQT 482
T+V++ Y+ SL + R GLC LAAD +W++K + ++DL + LD
Sbjct: 431 TTAVYMLYLLSLMQPK-PGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGE 489
Query: 483 GVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLI 542
V+AFL M+I ++ E +Y F ++FQEFFAA++Y+L + ++ RL+
Sbjct: 490 DVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAG----PDQDVTRLL 545
Query: 543 ASPRGS-KSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPS 601
S +S+L+ FLFG LNE S +E+S KVS K LL+ I + D +
Sbjct: 546 TEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGST 605
Query: 602 PGSGVPQLFYCLHEIREEAFVSQALNDYHKVVL-RIGNNKEVQVSAFCLKRC---QYLHE 657
G + F CL+EI+EE F+ QAL+ + +V+ I + E VS+FCLKRC Q LH
Sbjct: 606 LQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHL 665
Query: 658 VELTVTLNFMNVWKLSSSSHP-GSEAPESNG-LHRWWQDLCSVFATNDKLEVLTMTNSVL 715
T + + + + S+ +H + PE L + + L + TN L L++ + L
Sbjct: 666 YGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNAL 725
Query: 716 GPPFLKALAAALRHPQCKLQKLLLRRVN-STMLNQDLIGVLTGNQHLRYLEIQHVEVESK 774
G +K L LRHP CKLQ L L+R S+ +DL L N++L +++ V
Sbjct: 726 GSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFP 785
Query: 775 AVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAY 834
+ LLC LR P+CRLQ ++L C ++ + L N HL L L N+LE+ G
Sbjct: 786 GMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLR 845
Query: 835 YL------SVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIW 888
L V +L L ++ C LT C+ LAS L ++ L L L+ N L D G +
Sbjct: 846 LLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLC 905
Query: 889 NALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEAL 948
L H C LQ L L C L C+ + L N L+ LDLSFN L D G+ LL E L
Sbjct: 906 EGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGL 965
Query: 949 KNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006
++P C LQ L L++C T+ C+ + L NQ L L L+ NA+G G+ LC+ S
Sbjct: 966 QHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLS 1023
Score = 110 bits (274), Expect = 9e-24
Identities = 80/223 (35%), Positives = 110/223 (49%), Gaps = 7/223 (3%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQD-L 751
Q++ SV TN L L +T + L L+ L LRHP C+L+ L L+ T D L
Sbjct: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
Query: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
L+ NQ LR L++ E+ V LLC LR P C+LQ LRL C L
Sbjct: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
Query: 812 LQGNGHLKTLILRKNSLENCGAYYLS------VAQLERLSIENCNLTQLTCESLASCLRQ 865
LQ N +L+ L L N L + G + L+ +L++L +++C LT CE+L L
Sbjct: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDL 908
++ LT L L NAL D G + + L H C L+ L L DL
Sbjct: 997 NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDL 1039
Score = 76.6 bits (187), Expect = 1e-13
Identities = 38/102 (37%), Positives = 61/102 (59%)
Query: 914 QDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAM 973
+ + +ALC N L L L N+L GV LLC+ L++P+C LQ L L+ C +S C+ +
Sbjct: 703 EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
Query: 974 ASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
++ L N++L +DLS N +G G++ LCE + R ++I
Sbjct: 763 SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 460 bits (1183), Expect = e-129
Identities = 308/978 (31%), Positives = 496/978 (50%), Gaps = 33/978 (3%)
Query: 45 MRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103
+ ++ +EL+ FK LL L W +VE A ++ +L+ + T N
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
Query: 104 IFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFP 163
I MN ++C + + E+ E ++ +G+ + + E + G+ ++ N MEK
Sbjct: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWR-NSMEKQSL 132
Query: 164 IWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKV 223
+W T W G+ +F R++ ++P L P+ P+ P TV + G G+GKT LAKK
Sbjct: 133 VWKNTFWQGDIDNFHDDVTLRNQRFIP-FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
Query: 224 MFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLL 283
M +W R+ AFY C+E+++ SF+ELI + WP QD + I+++ ++L
Sbjct: 192 MLDWTDCNLSPTLRY-AFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
Query: 284 LLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCK 343
++DG +EL ++D+ DW +K P VLL SLL + MLP A LL+ R + + +
Sbjct: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
Query: 344 PLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVC 403
L + P V + GF ++ YF +FG ++ + N LF + P VCW+VC
Sbjct: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
Query: 404 SGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMW 463
+ LK QME+G + +C T +F+R++ S FP A+ + L L LAA +W
Sbjct: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LRGALRTLSLLAAQGLW 424
Query: 464 HRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCF 523
+ V +EDLE + ++ + FL ILR+ + Y F ++FQ+F ALFY L
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 524 PQ-RLKNFHVLSHVNIQRLIASPRGSKS-YLSHMGLFLFGFLNEACASAVEQSFQCKVSF 581
+ ++ H ++Q+L++ K+ L +G FLFG NE A +E +F C++S
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
Query: 582 GNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKE 641
K++LL+ LH + P + + ++ CL+E +EE + + ++ + + N E
Sbjct: 545 DIKQELLQCKAHLH-ANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
Query: 642 VQVSAFCLKRCQYLHEVELTVTL-----NFMN------VWKLSSSSHPGSEAPESNGLHR 690
V +F LK CQ L ++ L V N+M+ + + + P + L R
Sbjct: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSL-R 662
Query: 691 WWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQD 750
W D CS+F++N L+ L + S L ++ L + C LQK+ ++ V +D
Sbjct: 663 LWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD 722
Query: 751 LIGVLTGNQHLRYLEIQ-HVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLG 809
G + L +L + H+E E + +LC +LR+ +C LQ LRL ATP W +
Sbjct: 723 FCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
Query: 810 NNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLASCL 863
L+ N LK L L N L + GA L L+ LS+ENC LT+ +C+ LA+ L
Sbjct: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
Query: 864 RQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKN 923
SK LTHL LA+N + D G K + L + C LQ LVL++C +T C+ + AL +
Sbjct: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
Query: 924 KTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
+L +LDLS N + G+ +LC+AL+NP+C L+ L L +C CQ + S L NQ L
Sbjct: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
Query: 984 RHLDLSKNAIGVYGILTL 1001
LDL +N + GI+ L
Sbjct: 962 ETLDLGQNHLWKSGIIKL 979
Score = 87.8 bits (216), Expect = 5e-17
Identities = 72/234 (30%), Positives = 108/234 (46%), Gaps = 14/234 (5%)
Query: 780 CRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLEN------CGA 833
C L P Q LR + R+WTD + N +LK L ++++ L + C
Sbjct: 645 CTYLTIPNWARQDLR------SLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDH 698
Query: 834 YYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAK-HIWNALP 892
S L+++ I+N K LTHL+LA + + + + L
Sbjct: 699 VTRSTCHLQKVEIKNVT-PDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLR 757
Query: 893 HLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPD 952
+ +C LQ L L T + L N++LK L LS N L D+G +LL + + P
Sbjct: 758 NHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPK 817
Query: 953 CTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006
LQ+L LENC T C+ +A++L ++ L HL L+KN IG G+ LCE S
Sbjct: 818 HFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLS 871
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 441 bits (1133), Expect = e-123
Identities = 301/972 (30%), Positives = 486/972 (50%), Gaps = 49/972 (5%)
Query: 45 MRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103
+ ++ +EL+ FK LL L W +VE A ++ +L+ + T N
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
Query: 104 IFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFP 163
I MN ++C + + E+ E ++ +G+ + + E + G+ ++ N MEK
Sbjct: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWR-NSMEKQSL 132
Query: 164 IWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKV 223
+W T W G+ +F R++ ++P L P+ P+ P TV + G G+GKT LAKK
Sbjct: 133 VWKNTFWQGDIDNFHDDVTLRNQRFIP-FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
Query: 224 MFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLL 283
M +W R+ AFY C+E+++ SF+ELI + WP QD + I+++ ++L
Sbjct: 192 MLDWTDCNLSPTLRY-AFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
Query: 284 LLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCK 343
++DG +EL ++D+ DW +K P VLL SLL + MLP A LL+ R + + +
Sbjct: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
Query: 344 PLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVC 403
L + P V + GF ++ YF +FG ++ + N LF + P VCW+VC
Sbjct: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
Query: 404 SGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMW 463
+ LK QME+G + +C T +F+R++ S FP A+ + L L LAA +W
Sbjct: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LRGALRTLSLLAAQGLW 424
Query: 464 HRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCF 523
+ V +EDLE + ++ + FL ILR+ + Y F ++FQ+F ALFY L
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 524 PQ-RLKNFHVLSHVNIQRLIASPRGSKS-YLSHMGLFLFGFLNEACASAVEQSFQCKVSF 581
+ ++ H ++Q+L++ K+ L +G FLFG NE A +E +F C++S
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
Query: 582 GNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKE 641
K++LL+ LH + P + + ++ CL+E +EE + + ++ + + N E
Sbjct: 545 DIKQELLQCKAHLH-ANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
Query: 642 VQVSAFCLKRCQYLHEVELTVTL-----NFMNVWKLSSSSHPGSEAPESNGLHRWWQDLC 696
V +F LK CQ L ++ L V N+M+ ++L
Sbjct: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLENYMD-FELDIEFE------------------- 643
Query: 697 SVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLT 756
++N L+ L + S L ++ L + C LQK+ ++ V +D
Sbjct: 644 ---SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI 700
Query: 757 GNQHLRYLEIQ-HVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGN 815
G + L +L + H+E E + +LC +LR+ +C LQ LRL ATP W + L+ N
Sbjct: 701 GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKAN 760
Query: 816 GHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLASCLRQSKML 869
LK L L N L + GA L L+ LS+ENC LT+ +C+ LA+ L SK L
Sbjct: 761 QSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL 820
Query: 870 THLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
THL LA+N + D G K + L + C LQ LVL++C +T C+ + AL + +L +L
Sbjct: 821 THLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNL 880
Query: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
DLS N + G+ +LC+AL+NP+C L+ L L +C CQ + S L NQ L LDL
Sbjct: 881 DLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLG 939
Query: 990 KNAIGVYGILTL 1001
+N + GI+ L
Sbjct: 940 QNHLWKSGIIKL 951
Score = 77.8 bits (190), Expect = 5e-14
Identities = 62/199 (31%), Positives = 95/199 (47%), Gaps = 8/199 (4%)
Query: 815 NGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKM 868
N +LK L ++++ L + C S L+++ I+N K
Sbjct: 646 NSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVT-PDTAYRDFCLAFIGKKT 704
Query: 869 LTHLSLAENALKDEGAK-HIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
LTHL+LA + + + + L + +C LQ L L T + L N++LK
Sbjct: 705 LTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLK 764
Query: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
L LS N L D+G +LL + + P LQ+L LENC T C+ +A++L ++ L HL
Sbjct: 765 HLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLC 824
Query: 988 LSKNAIGVYGILTLCEAFS 1006
L+KN IG G+ LCE S
Sbjct: 825 LAKNPIGDTGVKFLCEGLS 843
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 436 bits (1122), Expect = e-122
Identities = 293/938 (31%), Positives = 477/938 (50%), Gaps = 33/938 (3%)
Query: 45 MRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103
+ ++ +EL+ FK LL L W +VE A ++ +L+ + T N
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
Query: 104 IFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFP 163
I MN ++C + + E+ E ++ +G+ + + E + G+ ++ N MEK
Sbjct: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWR-NSMEKQSL 132
Query: 164 IWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKV 223
+W T W G+ +F R++ ++P L P+ P+ P TV + G G+GKT LAKK
Sbjct: 133 VWKNTFWQGDIDNFHDDVTLRNQRFIP-FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
Query: 224 MFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLL 283
M +W R+ AFY C+E+++ SF+ELI + WP QD + I+++ ++L
Sbjct: 192 MLDWTDCNLSPTLRY-AFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
Query: 284 LLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCK 343
++DG +EL ++D+ DW +K P VLL SLL + MLP A LL+ R + + +
Sbjct: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
Query: 344 PLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVC 403
L + P V + GF ++ YF +FG ++ + N LF + P VCW+VC
Sbjct: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
Query: 404 SGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMW 463
+ LK QME+G + +C T +F+R++ S FP A+ + L L LAA +W
Sbjct: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LRGALRTLSLLAAQGLW 424
Query: 464 HRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCF 523
+ V +EDLE + ++ + FL ILR+ + Y F ++FQ+F ALFY L
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 524 PQ-RLKNFHVLSHVNIQRLIASPRGSKS-YLSHMGLFLFGFLNEACASAVEQSFQCKVSF 581
+ ++ H ++Q+L++ K+ L +G FLFG NE A +E +F C++S
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
Query: 582 GNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKE 641
K++LL+ LH + P + + ++ CL+E +EE + + ++ + + N E
Sbjct: 545 DIKQELLQCKAHLH-ANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
Query: 642 VQVSAFCLKRCQYLHEVELTVTL-----NFMN------VWKLSSSSHPGSEAPESNGLHR 690
V +F LK CQ L ++ L V N+M+ + + + P + L R
Sbjct: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSL-R 662
Query: 691 WWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQD 750
W D CS+F++N L+ L + S L ++ L + C LQK+ ++ V +D
Sbjct: 663 LWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD 722
Query: 751 LIGVLTGNQHLRYLEIQ-HVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLG 809
G + L +L + H+E E + +LC +LR+ +C LQ LRL ATP W +
Sbjct: 723 FCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
Query: 810 NNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLASCL 863
L+ N LK L L N L + GA L L+ LS+ENC LT+ +C+ LA+ L
Sbjct: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
Query: 864 RQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKN 923
SK LTHL LA+N + D G K + L + C LQ LVL++C +T C+ + AL +
Sbjct: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
Query: 924 KTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELE 961
+L +LDLS N + G+ +LC+AL+NP+C L+ L L+
Sbjct: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 435 bits (1118), Expect = e-121
Identities = 317/1028 (30%), Positives = 497/1028 (48%), Gaps = 107/1028 (10%)
Query: 44 YMRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTS 102
Y+ ++ +L++FK L G +P+ Q E A ++ L+I+ +AW +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 103 NIFAIMNCDKMCVVVRREI------NAIL--PTLEPEDLNVGE---------TQVNLEEG 145
IFA +N + +R+ NA + PT+ ++ ++ E +++++ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 146 ESGKIRRYKSNVMEKFFPIWDITTWPG-----NQRDFFYQGVHRHEEY------------ 188
+ ++Y+ V +F I D G N+R + + H
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 189 ------------LPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHK 236
+ L P TV QGA GIGKTILA+K+M +WA Y +
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 237 RWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLI 296
FY HC+EV+ T +S +LI P + KI+ KP ++L L+DGF+EL
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 297 DRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPG 356
+ + L DW++ G +LLSSL+ K +LPEA+LLI R + + + LL P V + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 357 FNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNL 416
F+ ++ +YF YF + S EN +LF+MC +P+VCW+VC+GLKQQME G +L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 417 TQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEE 476
Q+ T+V+V ++SSL R + + A L GLC LAAD +W++K + + DL
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC-AHLWGLCSLAADGIWNQKILFEESDLRN 491
Query: 477 AKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQ---------RL 527
L + V+AFL M++ ++ E Y F +TFQEFFAA++Y+L + RL
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 528 KNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRK 586
K L ++ L+ + + K YL + FLFG +N+ S +E+ CK+S + +
Sbjct: 552 K----LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
Query: 587 LLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSA 646
LLK I + K +LFYCL+E++EE FV +A++ + K+ + + + VS+
Sbjct: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
Query: 647 FCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLE 706
FC++ C H VE +++L F++ + E E G H
Sbjct: 668 FCIENC---HRVE-SLSLGFLH------NMPKEEEEEEKEGRH----------------- 700
Query: 707 VLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEI 766
L M VL + H C L+ + S+ + L VL+ +Q L L++
Sbjct: 701 -LDMVQCVL---------PSSSHAACS-HGLVNSHLTSSFC-RGLFSVLSTSQSLTELDL 748
Query: 767 QHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKN 826
+ +++LC L+ P C ++ L L C + D+ L N L L L N
Sbjct: 749 SDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDN 808
Query: 827 SLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALK 880
+L + G L V L++L + +C LT C+ LAS L S LT L + ENAL
Sbjct: 809 ALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALG 868
Query: 881 DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940
D G + + +C LQ+L L LT CC + S L N+ L L L N+L D G
Sbjct: 869 DSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKG 928
Query: 941 VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILT 1000
+ LLCE L +PDC LQ+LEL+NC TS CC ++++L +Q LR L L N +G G++
Sbjct: 929 IKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMM 988
Query: 1001 LCEAFSSQ 1008
CE Q
Sbjct: 989 FCEVLKQQ 996
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 435 bits (1118), Expect = e-121
Identities = 317/1028 (30%), Positives = 497/1028 (48%), Gaps = 107/1028 (10%)
Query: 44 YMRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTS 102
Y+ ++ +L++FK L G +P+ Q E A ++ L+I+ +AW +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 103 NIFAIMNCDKMCVVVRREI------NAIL--PTLEPEDLNVGE---------TQVNLEEG 145
IFA +N + +R+ NA + PT+ ++ ++ E +++++ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 146 ESGKIRRYKSNVMEKFFPIWDITTWPG-----NQRDFFYQGVHRHEEY------------ 188
+ ++Y+ V +F I D G N+R + + H
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 189 ------------LPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHK 236
+ L P TV QGA GIGKTILA+K+M +WA Y +
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 237 RWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLI 296
FY HC+EV+ T +S +LI P + KI+ KP ++L L+DGF+EL
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 297 DRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPG 356
+ + L DW++ G +LLSSL+ K +LPEA+LLI R + + + LL P V + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 357 FNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNL 416
F+ ++ +YF YF + S EN +LF+MC +P+VCW+VC+GLKQQME G +L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 417 TQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEE 476
Q+ T+V+V ++SSL R + + A L GLC LAAD +W++K + + DL
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC-AHLWGLCSLAADGIWNQKILFEESDLRN 491
Query: 477 AKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQ---------RL 527
L + V+AFL M++ ++ E Y F +TFQEFFAA++Y+L + RL
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 528 KNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRK 586
K L ++ L+ + + K YL + FLFG +N+ S +E+ CK+S + +
Sbjct: 552 K----LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
Query: 587 LLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSA 646
LLK I + K +LFYCL+E++EE FV +A++ + K+ + + + VS+
Sbjct: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
Query: 647 FCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLE 706
FC++ C H VE +++L F++ + E E G H
Sbjct: 668 FCIENC---HRVE-SLSLGFLH------NMPKEEEEEEKEGRH----------------- 700
Query: 707 VLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEI 766
L M VL + H C L+ + S+ + L VL+ +Q L L++
Sbjct: 701 -LDMVQCVL---------PSSSHAACS-HGLVNSHLTSSFC-RGLFSVLSTSQSLTELDL 748
Query: 767 QHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKN 826
+ +++LC L+ P C ++ L L C + D+ L N L L L N
Sbjct: 749 SDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDN 808
Query: 827 SLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALK 880
+L + G L V L++L + +C LT C+ LAS L S LT L + ENAL
Sbjct: 809 ALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALG 868
Query: 881 DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940
D G + + +C LQ+L L LT CC + S L N+ L L L N+L D G
Sbjct: 869 DSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKG 928
Query: 941 VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILT 1000
+ LLCE L +PDC LQ+LEL+NC TS CC ++++L +Q LR L L N +G G++
Sbjct: 929 IKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMM 988
Query: 1001 LCEAFSSQ 1008
CE Q
Sbjct: 989 FCEVLKQQ 996
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 427 bits (1098), Expect = e-119
Identities = 279/872 (31%), Positives = 447/872 (51%), Gaps = 34/872 (3%)
Query: 149 KIRRYKSNVMEKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAI 208
K R + + KF +W +WPG+ ++ R++ +P P+ G TV +
Sbjct: 156 KDNRCRYILKTKFREMWK--SWPGDSKEVQVMA-ERYKMLIP-FSNPRVLPGPFSYTVVL 211
Query: 209 QGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQ 268
G G+GKT LA+K+M +WA + HK AFY C+E+++ SF+EL+ + WP Q
Sbjct: 212 YGPAGLGKTTLAQKLMLDWAEDNLI-HKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQ 270
Query: 269 DLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEA 328
D + I+++ ++L ++DGF+EL + +ED+ DW +K P VLL SLL++ MLP+A
Sbjct: 271 DDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKA 330
Query: 329 TLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTI 388
LL+ R + + + L + P + + GF ++ YF +FG ++ + N
Sbjct: 331 ALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAA 390
Query: 389 LFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQ 448
LF + P VCW+VC+ LK QME+G + +C T +F+R++ S FP A+ +
Sbjct: 391 LFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LR 444
Query: 449 AQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLV 508
L L LAA +W + VL +EDLE + ++ + FL ILR+ + Y F +
Sbjct: 445 GALRTLSLLAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHL 504
Query: 509 TFQEFFAALFYVL-CFPQRLKNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEA 566
+FQ+F ALFY L + ++ H ++Q+L++ R L G + FG NE
Sbjct: 505 SFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQKLLSGVERLRNPDLIQAGYYSFGLANEK 564
Query: 567 CASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPG-----SGVPQLFYCLHEIREEAF 621
A +E +F C++S K++LL +CD G + + +L CL+E +EE
Sbjct: 565 RAKELEATFGCRMSPDIKQELL-------RCDISCKGGHSTVTDLQELLGCLYESQEEEL 617
Query: 622 VSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTL-NFMNVWKLSSSSHPGS 680
V + + + ++ L + N +V S+FC+K C+ L ++ L V N S S
Sbjct: 618 VKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSLQVIKENLPENVTASESDAEVE 676
Query: 681 EAPESNGLHRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLR 740
+ + + +W DLCS+F +N L L + +S L ++ L + C LQ+++ +
Sbjct: 677 RSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFK 736
Query: 741 RVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLA 800
++ +++L L G++ + YL +Q + + LC VLR P C L+ L L C A
Sbjct: 737 NISPADAHRNLCLALRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSA 795
Query: 801 TPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQL 854
T + W DL L+ N L + L N L + GA L L+RLS+ENC+LT+
Sbjct: 796 TTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEA 855
Query: 855 TCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQ 914
C+ LA+ L S+ LTHL LA+N + + G K + L + C LQ LVL CD+T + C
Sbjct: 856 NCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCC 915
Query: 915 DMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMA 974
D+ L + +L LDL N + G+ LCEAL+ P C L+ L L C C+ +
Sbjct: 916 DLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLC 975
Query: 975 SMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006
S L NQ L LDL +N +G G+ L E +
Sbjct: 976 SALSCNQSLVTLDLGQNPLGSSGVKMLFETLT 1007
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 417 bits (1072), Expect = e-116
Identities = 279/908 (30%), Positives = 453/908 (49%), Gaps = 39/908 (4%)
Query: 120 EINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFPIWDITTWPGNQRDFFY 179
E I +E E ET+ E+G G YKS+VM KF D+ +R F
Sbjct: 205 EEQEISQAMEQEGATAAETE---EQGHGGDTWDYKSHVMTKFAEEEDV------RRSFEN 255
Query: 180 QGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWC 239
E G +P+TV + G GIGK+ LA++++ WA+ Y
Sbjct: 256 TAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSY 315
Query: 240 AFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRL 299
F+ +E+ + + S +E I ++WP SQ V++IMS+P++LL ++DGF++L S L +
Sbjct: 316 VFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDT 375
Query: 300 EDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNT 359
+ L +DW +K P L+ SLL K +LPE+ L++ +R + K + P + + G +
Sbjct: 376 K-LCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISG 434
Query: 360 MEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGN----- 414
++I + Q L M N L C+VP V ++C L+ Q G
Sbjct: 435 EQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPF 494
Query: 415 NLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDL 474
N T + +A VF + R N ++ L+ C +A + +W+RK V +DL
Sbjct: 495 NQTLTGLHAAFVFHQLTPRGVVRRCLNLEERV---VLKRFCRMAVEGVWNRKSVFDGDDL 551
Query: 475 EEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLS 534
L ++ + A M+IL + E++Y F ++ Q+F AAL+YVL + L+ L
Sbjct: 552 MVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVL---EGLEIEPALC 608
Query: 535 HVNIQRLIASPR----GSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKV 590
+ +++ S G + M FLFG ++E +E C V G K+KLL
Sbjct: 609 PLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHW 668
Query: 591 IPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLK 650
+ LL + + F+CL E +++ FV ALN + +V L I N ++ S+FCL+
Sbjct: 669 VSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQ 728
Query: 651 RCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAP----ESNGLHRWWQDLCSVFATNDKLE 706
C YL ++ + V ++ S+ P + + W+D CS+ T+ L
Sbjct: 729 HCPYLRKIRVDVK----GIFPRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLR 784
Query: 707 VLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEI 766
L + +S+L +K L A LRHP CK+Q L+ R T Q L ++ N++LR L +
Sbjct: 785 QLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNL 844
Query: 767 QHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKN 826
++ + V++ C L+ P+C L+ LRL+ C T + + L + LK+L L N
Sbjct: 845 GGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGN 904
Query: 827 SLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALK 880
+ + G LS A L++L +E+C +T C+SLAS L ++ LTHL L+ N+L
Sbjct: 905 KVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLG 964
Query: 881 DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940
+EG + ++ C LQRL+L +C L C + AL N L L LS N ++D+G
Sbjct: 965 NEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNG 1024
Query: 941 VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILT 1000
V LLCE ++ P C LQ LEL C T+ CC++++ ++ +++HL+ LDL+ NA+G G+
Sbjct: 1025 VKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAA 1084
Query: 1001 LCEAFSSQ 1008
LCE +
Sbjct: 1085 LCEGLKQK 1092
Score = 131 bits (329), Expect = 4e-30
Identities = 91/279 (32%), Positives = 132/279 (47%), Gaps = 7/279 (2%)
Query: 689 HRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN 748
H + + + T+ L+ L++ + + + L+ ALR QC LQKL+L T
Sbjct: 880 HACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATG 939
Query: 749 -QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTD 807
Q L L N+ L +L + + + ++ V LLCR +R P C LQ L L C
Sbjct: 940 CQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGF 999
Query: 808 LGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLAS 861
L L GN L L L N +E+ G L L+ L + C+LT CESL+
Sbjct: 1000 LALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSC 1059
Query: 862 CLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALC 921
+ +S+ L L L +NAL D G + L L RL L+ C LT +CC+ + AL
Sbjct: 1060 VISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALS 1119
Query: 922 KNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
N+ L SL+L N+ G++ LC A P LQI+ L
Sbjct: 1120 CNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGL 1158
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 399 bits (1024), Expect = e-110
Identities = 300/1003 (29%), Positives = 479/1003 (47%), Gaps = 107/1003 (10%)
Query: 44 YMRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTS 102
Y+ ++ +L++FK L G +P+ Q E A ++ L+I+ +AW +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 103 NIFAIMNCDKMCVVVRREI------NAIL--PTLEPEDLNVGE---------TQVNLEEG 145
IFA +N + +R+ NA + PT+ ++ ++ E +++++ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 146 ESGKIRRYKSNVMEKFFPIWDITTWPG-----NQRDFFYQGVHRHEEY------------ 188
+ ++Y+ V +F I D G N+R + + H
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 189 ------------LPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHK 236
+ L P TV QGA GIGKTILA+K+M +WA Y +
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 237 RWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLI 296
FY HC+EV+ T +S +LI P + KI+ KP ++L L+DGF+EL
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 297 DRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPG 356
+ + L DW++ G +LLSSL+ K +LPEA+LLI R + + + LL P V + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 357 FNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNL 416
F+ ++ +YF YF + S EN +LF+MC +P+VCW+VC+GLKQQME G +L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 417 TQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEE 476
Q+ T+V+V ++SSL R + + A L GLC LAAD +W++K + + DL
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC-AHLWGLCSLAADGIWNQKILFEESDLRN 491
Query: 477 AKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQ---------RL 527
L + V+AFL M++ ++ E Y F +TFQEFFAA++Y+L + RL
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 528 KNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRK 586
K L ++ L+ + + K YL + FLFG +N+ S +E+ CK+S + +
Sbjct: 552 K----LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
Query: 587 LLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSA 646
LLK I + K +LFYCL+E++EE FV +A++ + K+ + + + VS+
Sbjct: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
Query: 647 FCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLE 706
FC++ C H VE +++L F++ + E E G H
Sbjct: 668 FCIENC---HRVE-SLSLGFLH------NMPKEEEEEEKEGRH----------------- 700
Query: 707 VLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEI 766
L M VL + H C L+ + S+ + L VL+ +Q L L++
Sbjct: 701 -LDMVQCVL---------PSSSHAACS-HGLVNSHLTSSFC-RGLFSVLSTSQSLTELDL 748
Query: 767 QHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKN 826
+ +++LC L+ P C ++ L L C + D+ L N L L L N
Sbjct: 749 SDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDN 808
Query: 827 SLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALK 880
+L + G L V L++L + N LT + C +L+S L ++ LTHL L N L
Sbjct: 809 ALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLG 868
Query: 881 DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940
D+G K + L H C LQ L L C+LT +CC D+ + L +++L+ L L N L D G
Sbjct: 869 DKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLG 928
Query: 941 VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
V++ CE LK C LQ L L F A+ ++ + L
Sbjct: 929 VMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPEL 971
Score = 127 bits (320), Expect = 4e-29
Identities = 78/219 (35%), Positives = 115/219 (52%), Gaps = 11/219 (5%)
Query: 792 CLRLEDCLATPRIWT--DLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIENC 849
C L L+T + T DL +N G+ ++ L +L++ G + RL + C
Sbjct: 730 CRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLC---ETLQHPGC------NIRRLWLGRC 780
Query: 850 NLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLT 909
L+ C ++ L ++ L L L++NAL D G + + L HL C L++L L LT
Sbjct: 781 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLT 840
Query: 910 FNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSIC 969
CC + S L N+ L L L N+L D G+ LLCE L +PDC LQ+LEL+NC TS C
Sbjct: 841 SVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 900
Query: 970 CQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQ 1008
C ++++L +Q LR L L N +G G++ CE Q
Sbjct: 901 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQ 939
Score = 122 bits (305), Expect = 2e-27
Identities = 68/156 (43%), Positives = 91/156 (58%)
Query: 848 NCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCD 907
N +LT C L S L S+ LT L L++N+L D G + + L H C ++RL L +C
Sbjct: 722 NSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCG 781
Query: 908 LTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTS 967
L+ CC D+ L N+ L LDLS N+L D G+ LLC LK+ C L+ L L N TS
Sbjct: 782 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTS 841
Query: 968 ICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
+CC A++S+L NQ+L HL L N +G GI LCE
Sbjct: 842 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 877
Score = 36.6 bits (83), Expect = 0.13
Identities = 19/44 (43%), Positives = 26/44 (59%)
Query: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
L N TS C+ + S+L +Q L LDLS N++G G+ LCE
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCE 763
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 397 bits (1021), Expect = e-110
Identities = 302/1003 (30%), Positives = 478/1003 (47%), Gaps = 107/1003 (10%)
Query: 44 YMRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTS 102
Y+ ++ +L++FK L G +P+ Q E A ++ L+I+ +AW +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 103 NIFAIMNCDKMCVVVRREI------NAIL--PTLEPEDLNVGE---------TQVNLEEG 145
IFA +N + +R+ NA + PT+ ++ ++ E +++++ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 146 ESGKIRRYKSNVMEKFFPIWDITTWPG-----NQRDFFYQGVHRHEEY------------ 188
+ ++Y+ V +F I D G N+R + + H
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 189 ------------LPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHK 236
+ L P TV QGA GIGKTILA+K+M +WA Y +
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 237 RWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLI 296
FY HC+EV+ T +S +LI P + KI+ KP ++L L+DGF+EL
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 297 DRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPG 356
+ + L DW++ G +LLSSL+ K +LPEA+LLI R + + + LL P V + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 357 FNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNL 416
F+ ++ +YF YF + S EN +LF+MC +P+VCW+VC+GLKQQME G +L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 417 TQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEE 476
Q+ T+V+V ++SSL R + + A L GLC LAAD +W++K + + DL
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC-AHLWGLCSLAADGIWNQKILFEESDLRN 491
Query: 477 AKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQ---------RL 527
L + V+AFL M++ ++ E Y F +TFQEFFAA++Y+L + RL
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 528 KNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRK 586
K L ++ L+ + + K YL + FLFG +N+ S +E+ CK+S + +
Sbjct: 552 K----LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
Query: 587 LLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSA 646
LLK I + K +LFYCL+E++EE FV +A++ + K+ + + + VS+
Sbjct: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
Query: 647 FCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVFATNDKLE 706
FC++ C H VE +++L F++ + E E G H
Sbjct: 668 FCIENC---HRVE-SLSLGFLH------NMPKEEEEEEKEGRH----------------- 700
Query: 707 VLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEI 766
L M VL P A + +C L S D+ VL+ NQ L L++
Sbjct: 701 -LDMVQCVL--PSSSHAACSHGLGRCGL---------SHECCFDISLVLSSNQKLVELDL 748
Query: 767 QHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKN 826
+ ++LLC L+ C L+ L L C T DL + L + L L + +N
Sbjct: 749 SDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGEN 808
Query: 827 SLENCGAYYLSV------AQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALK 880
+L + G L L++L + N LT + C +L+S L ++ LTHL L N L
Sbjct: 809 ALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLG 868
Query: 881 DEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDG 940
D+G K + L H C LQ L L C+LT +CC D+ + L +++L+ L L N L D G
Sbjct: 869 DKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLG 928
Query: 941 VILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
V++ CE LK C LQ L L F A+ ++ + L
Sbjct: 929 VMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPEL 971
Score = 135 bits (340), Expect = 2e-31
Identities = 81/208 (38%), Positives = 109/208 (52%), Gaps = 6/208 (2%)
Query: 807 DLGNNLQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLA 860
D+ L N L L L N+L + G L V L++L + +C LT C+ LA
Sbjct: 732 DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLA 791
Query: 861 SCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISAL 920
S L S LT L + ENAL D G + + +C LQ+L L LT CC + S L
Sbjct: 792 SVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVL 851
Query: 921 CKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKN 980
N+ L L L N+L D G+ LLCE L +PDC LQ+LEL+NC TS CC ++++L +
Sbjct: 852 STNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSS 911
Query: 981 QHLRHLDLSKNAIGVYGILTLCEAFSSQ 1008
Q LR L L N +G G++ CE Q
Sbjct: 912 QSLRKLSLGNNDLGDLGVMMFCEVLKQQ 939
Score = 124 bits (312), Expect = 4e-28
Identities = 67/155 (43%), Positives = 90/155 (58%)
Query: 849 CNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDL 908
C L+ C ++ L ++ L L L++NAL D G + + L HL C L++L L C L
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
Query: 909 TFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSI 968
T CCQD+ S L + +L L + N+L D GV +LCE KNP C LQ L L N TS+
Sbjct: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
Query: 969 CCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
CC A++S+L NQ+L HL L N +G GI LCE
Sbjct: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 877
Score = 83.6 bits (205), Expect = 9e-16
Identities = 44/101 (43%), Positives = 60/101 (59%)
Query: 903 LRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELEN 962
L +C L+ CC D+ L N+ L LDLS N+L D G+ LLC LK+ C L+ L L +
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 963 CLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
C TS CCQ +AS+L + L L + +NA+G G+ LCE
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 362 bits (928), Expect = 1e-99
Identities = 270/893 (30%), Positives = 435/893 (48%), Gaps = 93/893 (10%)
Query: 44 YMRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTS 102
Y+ ++ +L++FK L G +P+ Q E A ++ L+I+ +AW +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 103 NIFAIMNCDKMCVVVRREI------NAIL--PTLEPEDLNVGE---------TQVNLEEG 145
IFA +N + +R+ NA + PT+ ++ ++ E +++++ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 146 ESGKIRRYKSNVMEKFFPIWDITTWPG-----NQRDFFYQGVHRHEEY------------ 188
+ ++Y+ V +F I D G N+R + + H
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 189 ------------LPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHK 236
+ L P TV QGA GIGKTILA+K+M +WA Y +
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 237 RWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLI 296
FY HC+EV+ T +S +LI P + KI+ KP ++L L+DGF+EL
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 297 DRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPG 356
+ + L DW++ G +LLSSL+ K +LPEA+LLI R + + + LL P V + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 357 FNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNL 416
F+ ++ +YF YF + S EN +LF+MC +P+VCW+VC+GLKQQME G +L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 417 TQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEE 476
Q+ T+V+V ++SSL R + + A L GLC LAAD +W++K + + DL
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGL-CAHLWGLCSLAADGIWNQKILFEESDLRN 491
Query: 477 AKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVL---------CFPQRL 527
L + V+AFL M++ ++ E Y F +TFQEFFAA++Y+L RL
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 528 KNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKVSFGNKRK 586
K L ++ L+ + + K YL + FLFG +N+ S +E+ CK+S + +
Sbjct: 552 K----LPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
Query: 587 LLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKEVQVSA 646
LLK I + K +LFYCL+E++EE FV +A++ + K+ + + + VS+
Sbjct: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
Query: 647 FCLKRCQYLHEVELTVTLNF---------------MNVWKLSSSSHPGSEAPESNGL--- 688
FC++ C + + L N M L SSSH A S+GL
Sbjct: 668 FCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSH----AACSHGLGRC 723
Query: 689 ---HRWWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNST 745
H D+ V ++N KL L ++++ LG ++ L L+H C L+KL L VNS
Sbjct: 724 GLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL--VNSG 781
Query: 746 MLN---QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATP 802
+ + L VL+ NQ+L +L ++ + K +KLLC L P C+LQ L L++C T
Sbjct: 782 LTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTS 841
Query: 803 RIWTDLGNNLQGNGHLKTLILRKNSLENCGA-YYLSVAQLERLSIENCNLTQL 854
DL L + L+ L L N L + G + V + + ++N L+++
Sbjct: 842 HCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEM 894
Score = 122 bits (306), Expect = 2e-27
Identities = 64/160 (40%), Positives = 90/160 (56%)
Query: 849 CNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDL 908
C L+ C ++ L ++ L L L++NAL D G + + L HL C L++L L L
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782
Query: 909 TFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSI 968
T CC + S L N+ L L L N+L D G+ LLCE L +PDC LQ+LEL+NC TS
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842
Query: 969 CCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQ 1008
CC ++++L +Q LR L L N +G G++ CE Q
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQ 882
Score = 99.4 bits (246), Expect = 2e-20
Identities = 64/183 (34%), Positives = 91/183 (49%), Gaps = 6/183 (3%)
Query: 807 DLGNNLQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLA 860
D+ L N L L L N+L + G L V L++L + N LT + C +L+
Sbjct: 732 DISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALS 791
Query: 861 SCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISAL 920
S L ++ LTHL L N L D+G K + L H C LQ L L C+LT +CC D+ + L
Sbjct: 792 SVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLL 851
Query: 921 CKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKN 980
+++L+ L L N L D GV++ CE LK C LQ L L F A+ ++ +
Sbjct: 852 TSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEK 911
Query: 981 QHL 983
L
Sbjct: 912 PEL 914
Score = 87.0 bits (214), Expect = 8e-17
Identities = 47/101 (46%), Positives = 61/101 (60%)
Query: 903 LRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELEN 962
L +C L+ CC D+ L N+ L LDLS N+L D G+ LLC LK+ C L+ L L N
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 963 CLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
TS+CC A++S+L NQ+L HL L N +G GI LCE
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 820
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 348 bits (892), Expect = 2e-95
Identities = 265/974 (27%), Positives = 441/974 (45%), Gaps = 48/974 (4%)
Query: 41 VMLYMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDV 100
++ Y+ N+S +E Q FK+ L ++ +P + ++ E+ ++L + G+ W++
Sbjct: 11 LLWYLENLSDKEFQSFKKYLARKILDFKLP-QFPLIQMTK-EELANVLPISYEGQYIWNM 68
Query: 101 TSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEK 160
+IF++M + +C R+I +G N E K+ + K
Sbjct: 69 LFSIFSMMRKEDLC----RKI-------------IGRRNRNQEA--------CKAVMRRK 103
Query: 161 FFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQ-GRQPKTVAIQGAPGIGKTIL 219
F W+ T+ G F++ V Y+ L V + G GKTI+
Sbjct: 104 FMLQWESHTF-GKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIV 162
Query: 220 AKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPD 279
+ W + + + + + E+NQ T+ S +ELI + WP Q ++ I+S P
Sbjct: 163 INLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPK 222
Query: 280 QLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSW 339
+LL +L+ + + L L + QK+P VLL SLL + M P LI R T
Sbjct: 223 KLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRG 282
Query: 340 QTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVC 399
K LK T + ++ YF +F + L E+ IL +CRV ++C
Sbjct: 283 NNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILC 342
Query: 400 WMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAA 459
W+ C+ LK+QM++G + C T + +++ + A + + H L+ LC LAA
Sbjct: 343 WITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAA 402
Query: 460 DSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFY 519
++ EDL + V+ +IL +D Y F + QEF A+ +
Sbjct: 403 GGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAF 462
Query: 520 VLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKV 579
++ P N+ + S R R S + + F+FG LN +E SF ++
Sbjct: 463 LMAVP----NYLIPSG---SREYKEKREQYSDFNQVFTFIFGLLNANRRKILETSFGYQL 515
Query: 580 SFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNN 639
+ K V + H P + LFYCL+E REE FV ++ +V + + ++
Sbjct: 516 PMVDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSD 575
Query: 640 KEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVF 699
K++ VS +CL C +L ++L+V F N L + A + L +W+++CS+F
Sbjct: 576 KDMMVSLYCLDYCCHLRTLKLSVQRIFQNKEPLIRPT-----ASQMKSL-VYWREICSLF 629
Query: 700 ATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQ 759
T + L L + ++ L + L+ AL H CKL+ L L V++ +DL+ L N+
Sbjct: 630 YTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNR 689
Query: 760 HLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLK 819
L YL I + LL +L P C++ L L C ++ + L G L+
Sbjct: 690 SLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLR 749
Query: 820 TLILRKNSLENCGAYYLSVAQLE------RLSIENCNLTQLTCESLASCLRQSKMLTHLS 873
L L N L + G L A L L + C LT+ C +L L S L L
Sbjct: 750 KLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLD 809
Query: 874 LAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSF 933
L N LK+ G H+ L C L+ L L C + + CQ + + N+ L+SL++
Sbjct: 810 LCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGS 869
Query: 934 NSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAI 993
N ++D G+ LLC L++P+C L + LE C+ TS CC+++AS+L N+ L L+L +N +
Sbjct: 870 NKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHL 929
Query: 994 GVYGILTLCEAFSS 1007
G G+ L E+ S
Sbjct: 930 GNDGVAKLLESLIS 943
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 281 bits (720), Expect = 2e-75
Identities = 202/686 (29%), Positives = 335/686 (48%), Gaps = 51/686 (7%)
Query: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260
++P+ V +QGA GIGK+ LA++V W R + Y + FYF C+E+ Q+ S +ELI
Sbjct: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
Query: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320
+ + + +I+S+P++LL +LDG +E L + +L W Q P LL SLL
Sbjct: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
Query: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380
KT+LPEA+ LI R T+ Q P L+ V + GF+ + +YF YF + +
Sbjct: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
Query: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440
N L+++C VP V W+ C+ L QQM+R LT + T++ + Y+ A+
Sbjct: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
Query: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500
+ QL LC LAA+ +W +K + +DL + LD ++ FL M IL +
Sbjct: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
Query: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555
+H Y F + FQEFFAA+ YVL ++ + H +++++ + + + +
Sbjct: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
Query: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615
FL G L++ +E F C++S G R L++ +P L P + +CL+E
Sbjct: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
Query: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675
R + F++Q + + ++ + + + E+ V FC+K +++ +++L +
Sbjct: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
Query: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728
H + +P L RW WQ L SV L+ L ++ + L +K+L LR
Sbjct: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
Query: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787
P+C L+ L L T + +DL L NQ L L++ + K LC+ LR P
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQL 841
C+LQ L+L C T DL + L + LK L L++N+L++ G L +L
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Query: 842 ERLSIENCNLTQLTCESLASCLRQSK 867
RL ++ L+ + L + L Q K
Sbjct: 954 IRLGLDQTTLSDEMRQELRA-LEQEK 978
Score = 111 bits (277), Expect = 4e-24
Identities = 72/189 (38%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 801 TPRIWTDLGNNLQGNGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQL 854
T W L + L+ +LK L L NSL + C LE L + C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 855 TCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQ 914
C+ LA LR ++ LT L L+ N L D GAKH+ L C LQRL L C LT +CCQ
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 915 DMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMA 974
D+ S L + +LK LDL N+L D GV LLCE L++P C L L L+ + Q +
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
Query: 975 SMLRKNQHL 983
++ ++ L
Sbjct: 973 ALEQEKPQL 981
Score = 108 bits (269), Expect = 3e-23
Identities = 61/153 (39%), Positives = 84/153 (54%)
Query: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
+T + L S L+ ++ L L L+ N+L K + L RC L+ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
C+D+ L N+TL LDLSFN L D G LC+ L+ P C LQ L+L +C TS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Q +AS+L + L+ LDL +N + G+ LCE
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 821 LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
L+L+ +SLE+ Y + +A E + + C T + C++ S+ +
Sbjct: 709 LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
Query: 872 LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
L L E G +H W+ P ++ R +T Q + S L + LK L
Sbjct: 767 LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
Query: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
DLS NSL V LC+ L+ P C L+ L L C T+ C+ +A LR NQ L LDLS
Sbjct: 814 DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
Query: 990 KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017
N + G LC+ S + +R +++ C
Sbjct: 874 FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Score = 33.9 bits (76), Expect = 0.82
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 44 YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Y+ + EEL+ F+ LL + S+G P Q E S EV L+ ++ +RAWD
Sbjct: 12 YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 100 VTSNIFAIMNCDKMC 114
+ + + M +C
Sbjct: 69 LALHTWEQMGLRSLC 83
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 281 bits (720), Expect = 2e-75
Identities = 202/686 (29%), Positives = 335/686 (48%), Gaps = 51/686 (7%)
Query: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260
++P+ V +QGA GIGK+ LA++V W R + Y + FYF C+E+ Q+ S +ELI
Sbjct: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
Query: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320
+ + + +I+S+P++LL +LDG +E L + +L W Q P LL SLL
Sbjct: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
Query: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380
KT+LPEA+ LI R T+ Q P L+ V + GF+ + +YF YF + +
Sbjct: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
Query: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440
N L+++C VP V W+ C+ L QQM+R LT + T++ + Y+ A+
Sbjct: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
Query: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500
+ QL LC LAA+ +W +K + +DL + LD ++ FL M IL +
Sbjct: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
Query: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555
+H Y F + FQEFFAA+ YVL ++ + H +++++ + + + +
Sbjct: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
Query: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615
FL G L++ +E F C++S G R L++ +P L P + +CL+E
Sbjct: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
Query: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675
R + F++Q + + ++ + + + E+ V FC+K +++ +++L +
Sbjct: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
Query: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728
H + +P L RW WQ L SV L+ L ++ + L +K+L LR
Sbjct: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
Query: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787
P+C L+ L L T + +DL L NQ L L++ + K LC+ LR P
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQL 841
C+LQ L+L C T DL + L + LK L L++N+L++ G L +L
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Query: 842 ERLSIENCNLTQLTCESLASCLRQSK 867
RL ++ L+ + L + L Q K
Sbjct: 954 IRLGLDQTTLSDEMRQELRA-LEQEK 978
Score = 111 bits (277), Expect = 4e-24
Identities = 72/189 (38%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 801 TPRIWTDLGNNLQGNGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQL 854
T W L + L+ +LK L L NSL + C LE L + C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 855 TCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQ 914
C+ LA LR ++ LT L L+ N L D GAKH+ L C LQRL L C LT +CCQ
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 915 DMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMA 974
D+ S L + +LK LDL N+L D GV LLCE L++P C L L L+ + Q +
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
Query: 975 SMLRKNQHL 983
++ ++ L
Sbjct: 973 ALEQEKPQL 981
Score = 108 bits (269), Expect = 3e-23
Identities = 61/153 (39%), Positives = 84/153 (54%)
Query: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
+T + L S L+ ++ L L L+ N+L K + L RC L+ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
C+D+ L N+TL LDLSFN L D G LC+ L+ P C LQ L+L +C TS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Q +AS+L + L+ LDL +N + G+ LCE
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 821 LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
L+L+ +SLE+ Y + +A E + + C T + C++ S+ +
Sbjct: 709 LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
Query: 872 LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
L L E G +H W+ P ++ R +T Q + S L + LK L
Sbjct: 767 LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
Query: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
DLS NSL V LC+ L+ P C L+ L L C T+ C+ +A LR NQ L LDLS
Sbjct: 814 DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
Query: 990 KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017
N + G LC+ S + +R +++ C
Sbjct: 874 FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Score = 33.9 bits (76), Expect = 0.82
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 44 YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Y+ + EEL+ F+ LL + S+G P Q E S EV L+ ++ +RAWD
Sbjct: 12 YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 100 VTSNIFAIMNCDKMC 114
+ + + M +C
Sbjct: 69 LALHTWEQMGLRSLC 83
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 281 bits (720), Expect = 2e-75
Identities = 202/686 (29%), Positives = 335/686 (48%), Gaps = 51/686 (7%)
Query: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260
++P+ V +QGA GIGK+ LA++V W R + Y + FYF C+E+ Q+ S +ELI
Sbjct: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
Query: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320
+ + + +I+S+P++LL +LDG +E L + +L W Q P LL SLL
Sbjct: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
Query: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380
KT+LPEA+ LI R T+ Q P L+ V + GF+ + +YF YF + +
Sbjct: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
Query: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440
N L+++C VP V W+ C+ L QQM+R LT + T++ + Y+ A+
Sbjct: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
Query: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500
+ QL LC LAA+ +W +K + +DL + LD ++ FL M IL +
Sbjct: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
Query: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555
+H Y F + FQEFFAA+ YVL ++ + H +++++ + + + +
Sbjct: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
Query: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615
FL G L++ +E F C++S G R L++ +P L P + +CL+E
Sbjct: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
Query: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675
R + F++Q + + ++ + + + E+ V FC+K +++ +++L +
Sbjct: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
Query: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728
H + +P L RW WQ L SV L+ L ++ + L +K+L LR
Sbjct: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
Query: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787
P+C L+ L L T + +DL L NQ L L++ + K LC+ LR P
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQL 841
C+LQ L+L C T DL + L + LK L L++N+L++ G L +L
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Query: 842 ERLSIENCNLTQLTCESLASCLRQSK 867
RL ++ L+ + L + L Q K
Sbjct: 954 IRLGLDQTTLSDEMRQELRA-LEQEK 978
Score = 111 bits (277), Expect = 4e-24
Identities = 72/189 (38%), Positives = 96/189 (50%), Gaps = 6/189 (3%)
Query: 801 TPRIWTDLGNNLQGNGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQL 854
T W L + L+ +LK L L NSL + C LE L + C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 855 TCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQ 914
C+ LA LR ++ LT L L+ N L D GAKH+ L C LQRL L C LT +CCQ
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 915 DMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMA 974
D+ S L + +LK LDL N+L D GV LLCE L++P C L L L+ + Q +
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
Query: 975 SMLRKNQHL 983
++ ++ L
Sbjct: 973 ALEQEKPQL 981
Score = 108 bits (269), Expect = 3e-23
Identities = 61/153 (39%), Positives = 84/153 (54%)
Query: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
+T + L S L+ ++ L L L+ N+L K + L RC L+ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
C+D+ L N+TL LDLSFN L D G LC+ L+ P C LQ L+L +C TS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Q +AS+L + L+ LDL +N + G+ LCE
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 821 LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
L+L+ +SLE+ Y + +A E + + C T + C++ S+ +
Sbjct: 709 LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
Query: 872 LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
L L E G +H W+ P ++ R +T Q + S L + LK L
Sbjct: 767 LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
Query: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
DLS NSL V LC+ L+ P C L+ L L C T+ C+ +A LR NQ L LDLS
Sbjct: 814 DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
Query: 990 KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017
N + G LC+ S + +R +++ C
Sbjct: 874 FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Score = 33.9 bits (76), Expect = 0.82
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 44 YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Y+ + EEL+ F+ LL + S+G P Q E S EV L+ ++ +RAWD
Sbjct: 12 YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 100 VTSNIFAIMNCDKMC 114
+ + + M +C
Sbjct: 69 LALHTWEQMGLRSLC 83
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 281 bits (719), Expect = 2e-75
Identities = 199/667 (29%), Positives = 327/667 (49%), Gaps = 48/667 (7%)
Query: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260
++P+ V +QGA GIGK+ LA++V W R + Y + FYF C+E+ Q+ S +ELI
Sbjct: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
Query: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320
+ + + +I+S+P++LL +LDG +E L + +L W Q P LL SLL
Sbjct: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
Query: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380
KT+LPEA+ LI R T+ Q P L+ V + GF+ + +YF YF + +
Sbjct: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
Query: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440
N L+++C VP V W+ C+ L QQM+R LT + T++ + Y+ A+
Sbjct: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
Query: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500
+ QL LC LAA+ +W +K + +DL + LD ++ FL M IL +
Sbjct: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
Query: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555
+H Y F + FQEFFAA+ YVL ++ + H +++++ + + + +
Sbjct: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
Query: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615
FL G L++ +E F C++S G R L++ +P L P + +CL+E
Sbjct: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
Query: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675
R + F++Q + + ++ + + + E+ V FC+K +++ +++L +
Sbjct: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
Query: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728
H + +P L RW WQ L SV L+ L ++ + L +K+L LR
Sbjct: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
Query: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787
P+C L+ L L T + +DL L NQ L L++ + K LC+ LR P
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIE 847
C+LQ L+L C T DL + L + LK L L++N+L++ G L E L
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL----CEGLRHP 949
Query: 848 NCNLTQL 854
C L +L
Sbjct: 950 ACKLIRL 956
Score = 109 bits (273), Expect = 1e-23
Identities = 68/161 (42%), Positives = 85/161 (52%), Gaps = 6/161 (3%)
Query: 801 TPRIWTDLGNNLQGNGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQL 854
T W L + L+ +LK L L NSL + C LE L + C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 855 TCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQ 914
C+ LA LR ++ LT L L+ N L D GAKH+ L C LQRL L C LT +CCQ
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 915 DMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTL 955
D+ S L + +LK LDL N+L D GV LLCE L++P C L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 108 bits (269), Expect = 3e-23
Identities = 61/153 (39%), Positives = 84/153 (54%)
Query: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
+T + L S L+ ++ L L L+ N+L K + L RC L+ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
C+D+ L N+TL LDLSFN L D G LC+ L+ P C LQ L+L +C TS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Q +AS+L + L+ LDL +N + G+ LCE
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 88.2 bits (217), Expect = 4e-17
Identities = 59/159 (37%), Positives = 78/159 (49%), Gaps = 6/159 (3%)
Query: 749 QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
Q L VL ++L+ L++ + AVK LC+ LR PRC L+ LRL C T DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYLSV------AQLERLSIENCNLTQLTCESLASC 862
L+ N L L L N L + GA +L +L+RL + +C LT C+ LAS
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRL 901
L S L L L +N L D G + + L H C L RL
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 821 LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
L+L+ +SLE+ Y + +A E + + C T + C++ S+ +
Sbjct: 709 LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
Query: 872 LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
L L E G +H W+ P ++ R +T Q + S L + LK L
Sbjct: 767 LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
Query: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
DLS NSL V LC+ L+ P C L+ L L C T+ C+ +A LR NQ L LDLS
Sbjct: 814 DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
Query: 990 KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017
N + G LC+ S + +R +++ C
Sbjct: 874 FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Score = 33.9 bits (76), Expect = 0.82
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 44 YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Y+ + EEL+ F+ LL + S+G P Q E S EV L+ ++ +RAWD
Sbjct: 12 YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 100 VTSNIFAIMNCDKMC 114
+ + + M +C
Sbjct: 69 LALHTWEQMGLRSLC 83
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 281 bits (719), Expect = 2e-75
Identities = 199/667 (29%), Positives = 327/667 (49%), Gaps = 48/667 (7%)
Query: 201 RQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELI 260
++P+ V +QGA GIGK+ LA++V W R + Y + FYF C+E+ Q+ S +ELI
Sbjct: 325 QEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELI 384
Query: 261 EQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLL 320
+ + + +I+S+P++LL +LDG +E L + +L W Q P LL SLL
Sbjct: 385 GKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLL 444
Query: 321 SKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVL 380
KT+LPEA+ LI R T+ Q P L+ V + GF+ + +YF YF + +
Sbjct: 445 GKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAF 504
Query: 381 SFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAE 440
N L+++C VP V W+ C+ L QQM+R LT + T++ + Y+ A+
Sbjct: 505 RLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYL-------AQ 557
Query: 441 NFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEE 500
+ QL LC LAA+ +W +K + +DL + LD ++ FL M IL +
Sbjct: 558 ALQAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGIL------Q 611
Query: 501 DH-----YVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHM 555
+H Y F + FQEFFAA+ YVL ++ + H +++++ + + + +
Sbjct: 612 EHPIPLSYSFIHLCFQEFFAAMSYVL-EDEKGRGKHSNCIIDLEKTLEAYGIHGLFGAST 670
Query: 556 GLFLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHE 615
FL G L++ +E F C++S G R L++ +P L P + +CL+E
Sbjct: 671 TRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHS----LESLHCLYE 724
Query: 616 IREEAFVSQALNDYHKVVLRIGNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSS 675
R + F++Q + + ++ + + + E+ V FC+K +++ +++L +
Sbjct: 725 TRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL-----------IEGR 773
Query: 676 SHPGSEAPESNGLHRW-------WQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALR 728
H + +P L RW WQ L SV L+ L ++ + L +K+L LR
Sbjct: 774 QHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLR 833
Query: 729 HPQCKLQKLLLRRVNSTMLN-QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPR 787
P+C L+ L L T + +DL L NQ L L++ + K LC+ LR P
Sbjct: 834 RPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPS 893
Query: 788 CRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYLSVAQLERLSIE 847
C+LQ L+L C T DL + L + LK L L++N+L++ G L E L
Sbjct: 894 CKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLL----CEGLRHP 949
Query: 848 NCNLTQL 854
C L +L
Sbjct: 950 ACKLIRL 956
Score = 109 bits (273), Expect = 1e-23
Identities = 68/161 (42%), Positives = 85/161 (52%), Gaps = 6/161 (3%)
Query: 801 TPRIWTDLGNNLQGNGHLKTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQL 854
T W L + L+ +LK L L NSL + C LE L + C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 855 TCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQ 914
C+ LA LR ++ LT L L+ N L D GAKH+ L C LQRL L C LT +CCQ
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 915 DMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTL 955
D+ S L + +LK LDL N+L D GV LLCE L++P C L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 108 bits (269), Expect = 3e-23
Identities = 61/153 (39%), Positives = 84/153 (54%)
Query: 851 LTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF 910
+T + L S L+ ++ L L L+ N+L K + L RC L+ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 911 NCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICC 970
C+D+ L N+TL LDLSFN L D G LC+ L+ P C LQ L+L +C TS CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 971 QAMASMLRKNQHLRHLDLSKNAIGVYGILTLCE 1003
Q +AS+L + L+ LDL +N + G+ LCE
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCE 944
Score = 88.2 bits (217), Expect = 4e-17
Identities = 59/159 (37%), Positives = 78/159 (49%), Gaps = 6/159 (3%)
Query: 749 QDLIGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
Q L VL ++L+ L++ + AVK LC+ LR PRC L+ LRL C T DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYLSV------AQLERLSIENCNLTQLTCESLASC 862
L+ N L L L N L + GA +L +L+RL + +C LT C+ LAS
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRL 901
L S L L L +N L D G + + L H C L RL
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 69.7 bits (169), Expect = 1e-11
Identities = 62/211 (29%), Positives = 95/211 (45%), Gaps = 29/211 (13%)
Query: 821 LILRKNSLENCGAYYLS---------VAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
L+L+ +SLE+ Y + +A E + + C T + C++ S+ +
Sbjct: 709 LLLQPHSLESLHCLYETRNKTFLTQVMAHFEEMGM--CVETDMELLVCTFCIKFSRHVKK 766
Query: 872 LSLAENALKDEGAKH--IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSL 929
L L E G +H W+ P ++ R +T Q + S L + LK L
Sbjct: 767 LQLIE------GRQHRSTWS-------PTMVVLFRWVPVTDAYWQILFSVLKVTRNLKEL 813
Query: 930 DLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLS 989
DLS NSL V LC+ L+ P C L+ L L C T+ C+ +A LR NQ L LDLS
Sbjct: 814 DLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLS 873
Query: 990 KNAIGVYGILTLCEAF---SSQKKREEVIFC 1017
N + G LC+ S + +R +++ C
Sbjct: 874 FNVLTDAGAKHLCQRLRQPSCKLQRLQLVSC 904
Score = 33.9 bits (76), Expect = 0.82
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 7/75 (9%)
Query: 44 YMRNVSHEELQRFKQLLLTEL----STGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Y+ + EEL+ F+ LL + S+G P Q E S EV L+ ++ +RAWD
Sbjct: 12 YLEFLKKEELKEFQLLLANKAHSRSSSGETPA---QPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 100 VTSNIFAIMNCDKMC 114
+ + + M +C
Sbjct: 69 LALHTWEQMGLRSLC 83
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 212 bits (540), Expect = 1e-54
Identities = 185/678 (27%), Positives = 307/678 (45%), Gaps = 89/678 (13%)
Query: 193 LLPKRPQGRQPKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEV-NQT 251
L + +GR+P TV +QG GIGKT+ AKK++++WA K Y + AF+ C E+ +
Sbjct: 185 LFRRDEEGRRPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERP 244
Query: 252 TDQSFSELIEQKWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLP 311
+S ++LI + P V +++++P +LL +LDG +EL + ++ + +
Sbjct: 245 GTRSLADLILDQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPF-EAAS 303
Query: 312 GSVLLSSLLSKTMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFG 371
G+ +L LLSK +LP A LL+ R + + L P + GF+ +K KYF +F
Sbjct: 304 GARVLGGLLSKALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFR 363
Query: 372 HTEEGDQVLSFAMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYI 431
++ F EN LF++C VP VCW+VC+ L+QQ+E G +L+++ TSV++ +I
Sbjct: 364 DERRAERAYRFVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFI 423
Query: 432 SSLFPTRAENFSRKIHQAQLEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGV-TAFLGM 490
+S+ + ++ Q L LC LA + + R+ +++LE+ +L + V T FL
Sbjct: 424 TSVLSSAPVADGPRL-QGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSK 482
Query: 491 SILRRIAGEEDHYVFTLVTFQEFFAALFYVLCFPQRLKNFHVLSHVNIQRLIASP----- 545
L + E Y F +FQEF AAL Y +L + R A
Sbjct: 483 KELPGVLETEVTYQFIDQSFQEFLAALSY------------LLEDGGVPRTAAGGVGTLL 530
Query: 546 RGSKSYLSHMGL---FLFGFLNEACASAVEQSFQCKVSFGNKRKLLKVIP---------- 592
RG SH+ L FLFG L+ +E+ F C VS K++ L+ +
Sbjct: 531 RGDAQPHSHLVLTTRFLFGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVA 590
Query: 593 ---------LLHKCDPPSPGSGVP-----QLFYCLHEIREEAFVSQALNDYHKVVLRIGN 638
L +P G +L YCL+E +E+AFV QAL + ++ L+
Sbjct: 591 PEVTEGAKGLEDTEEPEEEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVR 650
Query: 639 --NKEVQVSAFCLKRC---QYLHEVELTVTLNFMNVWKL-----------SSSSHPGSEA 682
+V V ++C++ C Q L + + K SSS ++
Sbjct: 651 FCRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQ 710
Query: 683 PESNGLHRWWQ-------------------------DLCSVFATNDKLEVLTMTNSVLGP 717
++ LH +Q DL L L + ++ L
Sbjct: 711 LPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSE 770
Query: 718 PFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQHLRYLEIQHVEVESKAVK 777
L+ L+ L PQC++Q + ++ + Q L+G+L + L L++ ++ + V
Sbjct: 771 AGLRMLSEGLAWPQCRVQTVRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVT 830
Query: 778 LLCRVLRSPRCRLQCLRL 795
LC VL+ C LQ L L
Sbjct: 831 YLCAVLQHQGCGLQTLSL 848
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/146 (26%), Positives = 65/146 (44%), Gaps = 1/146 (0%)
Query: 838 VAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCP 897
+ L L++ +C L C L+ LR + LT L L N L + G + + L +C
Sbjct: 727 LCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCR 786
Query: 898 LQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQI 957
+Q + ++ D Q ++ L ++ L +LDLS L V LC L++ C LQ
Sbjct: 787 VQTVRVQLPDPQRGL-QYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQT 845
Query: 958 LELENCLFTSICCQAMASMLRKNQHL 983
L L + + Q + ++ R L
Sbjct: 846 LSLASVELSEQSLQELQAVKRAKPDL 871
Score = 45.8 bits (107), Expect = 2e-04
Identities = 35/122 (28%), Positives = 52/122 (42%), Gaps = 1/122 (0%)
Query: 887 IWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCE 946
++ A+ C L L L C L C+D+ AL L L L N L + G+ +L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 947 ALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFS 1006
L P C +Q + ++ Q + MLR++ L LDLS + + LC
Sbjct: 779 GLAWPQCRVQTVRVQ-LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 1007 SQ 1008
Q
Sbjct: 838 HQ 839
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 181 bits (458), Expect = 4e-45
Identities = 101/320 (31%), Positives = 175/320 (54%), Gaps = 6/320 (1%)
Query: 203 PKTVAIQGAPGIGKTILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQ 262
P V +QG+ G GKT LA+K++ +WA Y + FY C+EV + +L+
Sbjct: 166 PSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFW 225
Query: 263 KWPGSQDLVSKIMSKPDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSK 322
+Q V++I+ +P++LL +LDGF+EL ++L+ R P LL L+ +
Sbjct: 226 CCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRR 280
Query: 323 TMLPEATLLIMIRFTSWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSF 382
LP +LLI R + + +PLLK V + GF+ E+ +YF YF ++ D+
Sbjct: 281 HTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDI 340
Query: 383 AMENTILFSMCRVPVVCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENF 442
+N IL+ C+VP +CW+VCS L+ QMERG + ++ N+T +F+ Y+S+ P +
Sbjct: 341 VQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGG 400
Query: 443 SRKIHQAQ-LEGLCHLAADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEED 501
++ + + L LC LAA+ + H++++ + +L + LD + AFL + + +
Sbjct: 401 CSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKK 460
Query: 502 HYVFTLVTFQEFFAALFYVL 521
Y F ++FQ+FF A+ Y++
Sbjct: 461 FYSFRHISFQDFFHAMSYLV 480
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 161 bits (408), Expect = 3e-39
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)
Query: 695 LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753
L S T L+ L +++++LG L+ L L PQC+L+KL L + + + + L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 754 VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813
VL + L + + ++ V++LC+ L+ C+L+ L+LE C T DL +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 814 GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867
L+ L L N L E C ++L L I C +T C L LR +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 868 MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
L LSLA N L DEGA+ + L C L+ L ++ C T CC S L +N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
L +S N L+D GV LC+ L P L++L L +C + C ++A+ L N LR LD
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 988 LSKNAIGVYGILTLCEA 1004
LS N +G GIL L E+
Sbjct: 405 LSNNCLGDAGILQLVES 421
Score = 149 bits (375), Expect = 2e-35
Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
+D+ S N L L + ++ LG + + L+ P CK+QKL L+ + L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
Query: 753 GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
GVL+ L+ L + + ++LLC L P+CRL+ L+LE C + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862
+ L+ K L + N + G L S QLE L +E+C +T C L
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922
+ L L+L N L D G + L H L+ L + +C +T C D+ L
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 923 NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982
++LK L L+ N L D+G LLCE L P C L+ L +++C FT+ CC +S+L +N+
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 983 LRHLDLSKNAIGVYGILTLCE 1003
L L +S N + G+ LC+
Sbjct: 343 LLELQISNNRLEDAGVRELCQ 363
Score = 118 bits (295), Expect = 3e-26
Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)
Query: 791 QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844
Q +RL+DC T D+ + L+ N L L LR N L + G + + ++++L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 845 SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904
S++NC LT C L+S LR L L L++N L D G + + L +C L++L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 905 KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964
C L+ C+ + S L K L +S N + + GV +LC+ LK+ C L+ L+LE+C
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 965 FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002
TS C+ + ++ LR L L N +G G+ LC
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
Score = 118 bits (295), Expect = 3e-26
Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
+ L SV + LT++N+ + ++ L L+ C+L+ L L T N +DL
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
G++ LR L + ++ + LC L P RL+ L + +C T + DL
Sbjct: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
Query: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
L+ LK L L N L + GA L QLE L +++C+ T C +S L Q
Sbjct: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
++ L L ++ N L+D G + + L L+ L L CD++ + C + + L N +
Sbjct: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
Query: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 107 bits (266), Expect = 8e-23
Identities = 60/176 (34%), Positives = 92/176 (52%)
Query: 840 QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899
Q + + +++C LT+ C+ ++S LR + L L+L N L D G + L C +Q
Sbjct: 29 QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
Query: 900 RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959
+L L+ C LT C + S L TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 89 KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
LE C ++ C+ +AS+LR + L +S N I G+ LC+ + E +
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
Score = 74.3 bits (181), Expect = 6e-13
Identities = 47/126 (37%), Positives = 62/126 (49%)
Query: 888 WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947
W L L Q + L C LT C+D+ SAL N L L+L N L D GV + +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 948 LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007
L+ P C +Q L L+NC T C ++S LR L+ L LS N +G G+ LCE
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 1008 QKKREE 1013
+ R E
Sbjct: 140 PQCRLE 145
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 161 bits (408), Expect = 3e-39
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)
Query: 695 LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753
L S T L+ L +++++LG L+ L L PQC+L+KL L + + + + L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 754 VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813
VL + L + + ++ V++LC+ L+ C+L+ L+LE C T DL +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 814 GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867
L+ L L N L E C ++L L I C +T C L LR +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 868 MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
L LSLA N L DEGA+ + L C L+ L ++ C T CC S L +N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
L +S N L+D GV LC+ L P L++L L +C + C ++A+ L N LR LD
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 988 LSKNAIGVYGILTLCEA 1004
LS N +G GIL L E+
Sbjct: 405 LSNNCLGDAGILQLVES 421
Score = 149 bits (375), Expect = 2e-35
Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
+D+ S N L L + ++ LG + + L+ P CK+QKL L+ + L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
Query: 753 GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
GVL+ L+ L + + ++LLC L P+CRL+ L+LE C + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862
+ L+ K L + N + G L S QLE L +E+C +T C L
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922
+ L L+L N L D G + L H L+ L + +C +T C D+ L
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 923 NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982
++LK L L+ N L D+G LLCE L P C L+ L +++C FT+ CC +S+L +N+
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 983 LRHLDLSKNAIGVYGILTLCE 1003
L L +S N + G+ LC+
Sbjct: 343 LLELQISNNRLEDAGVRELCQ 363
Score = 118 bits (295), Expect = 3e-26
Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)
Query: 791 QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844
Q +RL+DC T D+ + L+ N L L LR N L + G + + ++++L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 845 SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904
S++NC LT C L+S LR L L L++N L D G + + L +C L++L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 905 KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964
C L+ C+ + S L K L +S N + + GV +LC+ LK+ C L+ L+LE+C
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 965 FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002
TS C+ + ++ LR L L N +G G+ LC
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
Score = 118 bits (295), Expect = 3e-26
Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
+ L SV + LT++N+ + ++ L L+ C+L+ L L T N +DL
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
G++ LR L + ++ + LC L P RL+ L + +C T + DL
Sbjct: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
Query: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
L+ LK L L N L + GA L QLE L +++C+ T C +S L Q
Sbjct: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
++ L L ++ N L+D G + + L L+ L L CD++ + C + + L N +
Sbjct: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
Query: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 107 bits (266), Expect = 8e-23
Identities = 60/176 (34%), Positives = 92/176 (52%)
Query: 840 QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899
Q + + +++C LT+ C+ ++S LR + L L+L N L D G + L C +Q
Sbjct: 29 QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
Query: 900 RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959
+L L+ C LT C + S L TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 89 KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
LE C ++ C+ +AS+LR + L +S N I G+ LC+ + E +
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
Score = 74.3 bits (181), Expect = 6e-13
Identities = 47/126 (37%), Positives = 62/126 (49%)
Query: 888 WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947
W L L Q + L C LT C+D+ SAL N L L+L N L D GV + +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 948 LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007
L+ P C +Q L L+NC T C ++S LR L+ L LS N +G G+ LCE
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 1008 QKKREE 1013
+ R E
Sbjct: 140 PQCRLE 145
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 161 bits (408), Expect = 3e-39
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)
Query: 695 LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753
L S T L+ L +++++LG L+ L L PQC+L+KL L + + + + L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 754 VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813
VL + L + + ++ V++LC+ L+ C+L+ L+LE C T DL +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 814 GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867
L+ L L N L E C ++L L I C +T C L LR +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 868 MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
L LSLA N L DEGA+ + L C L+ L ++ C T CC S L +N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
L +S N L+D GV LC+ L P L++L L +C + C ++A+ L N LR LD
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 988 LSKNAIGVYGILTLCEA 1004
LS N +G GIL L E+
Sbjct: 405 LSNNCLGDAGILQLVES 421
Score = 149 bits (375), Expect = 2e-35
Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
+D+ S N L L + ++ LG + + L+ P CK+QKL L+ + L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
Query: 753 GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
GVL+ L+ L + + ++LLC L P+CRL+ L+LE C + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862
+ L+ K L + N + G L S QLE L +E+C +T C L
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922
+ L L+L N L D G + L H L+ L + +C +T C D+ L
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 923 NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982
++LK L L+ N L D+G LLCE L P C L+ L +++C FT+ CC +S+L +N+
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 983 LRHLDLSKNAIGVYGILTLCE 1003
L L +S N + G+ LC+
Sbjct: 343 LLELQISNNRLEDAGVRELCQ 363
Score = 118 bits (295), Expect = 3e-26
Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)
Query: 791 QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844
Q +RL+DC T D+ + L+ N L L LR N L + G + + ++++L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 845 SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904
S++NC LT C L+S LR L L L++N L D G + + L +C L++L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 905 KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964
C L+ C+ + S L K L +S N + + GV +LC+ LK+ C L+ L+LE+C
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 965 FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002
TS C+ + ++ LR L L N +G G+ LC
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
Score = 118 bits (295), Expect = 3e-26
Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
+ L SV + LT++N+ + ++ L L+ C+L+ L L T N +DL
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
G++ LR L + ++ + LC L P RL+ L + +C T + DL
Sbjct: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
Query: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
L+ LK L L N L + GA L QLE L +++C+ T C +S L Q
Sbjct: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
++ L L ++ N L+D G + + L L+ L L CD++ + C + + L N +
Sbjct: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
Query: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 107 bits (266), Expect = 8e-23
Identities = 60/176 (34%), Positives = 92/176 (52%)
Query: 840 QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899
Q + + +++C LT+ C+ ++S LR + L L+L N L D G + L C +Q
Sbjct: 29 QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
Query: 900 RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959
+L L+ C LT C + S L TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 89 KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
LE C ++ C+ +AS+LR + L +S N I G+ LC+ + E +
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
Score = 74.3 bits (181), Expect = 6e-13
Identities = 47/126 (37%), Positives = 62/126 (49%)
Query: 888 WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947
W L L Q + L C LT C+D+ SAL N L L+L N L D GV + +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 948 LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007
L+ P C +Q L L+NC T C ++S LR L+ L LS N +G G+ LCE
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 1008 QKKREE 1013
+ R E
Sbjct: 140 PQCRLE 145
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 161 bits (408), Expect = 3e-39
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)
Query: 695 LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753
L S T L+ L +++++LG L+ L L PQC+L+KL L + + + + L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 754 VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813
VL + L + + ++ V++LC+ L+ C+L+ L+LE C T DL +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 814 GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867
L+ L L N L E C ++L L I C +T C L LR +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 868 MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
L LSLA N L DEGA+ + L C L+ L ++ C T CC S L +N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
L +S N L+D GV LC+ L P L++L L +C + C ++A+ L N LR LD
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 988 LSKNAIGVYGILTLCEA 1004
LS N +G GIL L E+
Sbjct: 405 LSNNCLGDAGILQLVES 421
Score = 149 bits (375), Expect = 2e-35
Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
+D+ S N L L + ++ LG + + L+ P CK+QKL L+ + L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
Query: 753 GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
GVL+ L+ L + + ++LLC L P+CRL+ L+LE C + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862
+ L+ K L + N + G L S QLE L +E+C +T C L
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922
+ L L+L N L D G + L H L+ L + +C +T C D+ L
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 923 NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982
++LK L L+ N L D+G LLCE L P C L+ L +++C FT+ CC +S+L +N+
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 983 LRHLDLSKNAIGVYGILTLCE 1003
L L +S N + G+ LC+
Sbjct: 343 LLELQISNNRLEDAGVRELCQ 363
Score = 118 bits (295), Expect = 3e-26
Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)
Query: 791 QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844
Q +RL+DC T D+ + L+ N L L LR N L + G + + ++++L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 845 SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904
S++NC LT C L+S LR L L L++N L D G + + L +C L++L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 905 KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964
C L+ C+ + S L K L +S N + + GV +LC+ LK+ C L+ L+LE+C
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 965 FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002
TS C+ + ++ LR L L N +G G+ LC
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
Score = 118 bits (295), Expect = 3e-26
Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
+ L SV + LT++N+ + ++ L L+ C+L+ L L T N +DL
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
G++ LR L + ++ + LC L P RL+ L + +C T + DL
Sbjct: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
Query: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
L+ LK L L N L + GA L QLE L +++C+ T C +S L Q
Sbjct: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
++ L L ++ N L+D G + + L L+ L L CD++ + C + + L N +
Sbjct: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
Query: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 107 bits (266), Expect = 8e-23
Identities = 60/176 (34%), Positives = 92/176 (52%)
Query: 840 QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899
Q + + +++C LT+ C+ ++S LR + L L+L N L D G + L C +Q
Sbjct: 29 QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
Query: 900 RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959
+L L+ C LT C + S L TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 89 KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
LE C ++ C+ +AS+LR + L +S N I G+ LC+ + E +
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
Score = 74.3 bits (181), Expect = 6e-13
Identities = 47/126 (37%), Positives = 62/126 (49%)
Query: 888 WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947
W L L Q + L C LT C+D+ SAL N L L+L N L D GV + +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 948 LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007
L+ P C +Q L L+NC T C ++S LR L+ L LS N +G G+ LCE
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 1008 QKKREE 1013
+ R E
Sbjct: 140 PQCRLE 145
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 161 bits (408), Expect = 3e-39
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)
Query: 695 LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753
L S T L+ L +++++LG L+ L L PQC+L+KL L + + + + L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 754 VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813
VL + L + + ++ V++LC+ L+ C+L+ L+LE C T DL +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 814 GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867
L+ L L N L E C ++L L I C +T C L LR +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 868 MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
L LSLA N L DEGA+ + L C L+ L ++ C T CC S L +N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
L +S N L+D GV LC+ L P L++L L +C + C ++A+ L N LR LD
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 988 LSKNAIGVYGILTLCEA 1004
LS N +G GIL L E+
Sbjct: 405 LSNNCLGDAGILQLVES 421
Score = 149 bits (375), Expect = 2e-35
Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
+D+ S N L L + ++ LG + + L+ P CK+QKL L+ + L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
Query: 753 GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
GVL+ L+ L + + ++LLC L P+CRL+ L+LE C + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862
+ L+ K L + N + G L S QLE L +E+C +T C L
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922
+ L L+L N L D G + L H L+ L + +C +T C D+ L
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 923 NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982
++LK L L+ N L D+G LLCE L P C L+ L +++C FT+ CC +S+L +N+
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 983 LRHLDLSKNAIGVYGILTLCE 1003
L L +S N + G+ LC+
Sbjct: 343 LLELQISNNRLEDAGVRELCQ 363
Score = 118 bits (295), Expect = 3e-26
Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)
Query: 791 QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844
Q +RL+DC T D+ + L+ N L L LR N L + G + + ++++L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 845 SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904
S++NC LT C L+S LR L L L++N L D G + + L +C L++L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 905 KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964
C L+ C+ + S L K L +S N + + GV +LC+ LK+ C L+ L+LE+C
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 965 FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002
TS C+ + ++ LR L L N +G G+ LC
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
Score = 118 bits (295), Expect = 3e-26
Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
+ L SV + LT++N+ + ++ L L+ C+L+ L L T N +DL
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
G++ LR L + ++ + LC L P RL+ L + +C T + DL
Sbjct: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
Query: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
L+ LK L L N L + GA L QLE L +++C+ T C +S L Q
Sbjct: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
++ L L ++ N L+D G + + L L+ L L CD++ + C + + L N +
Sbjct: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
Query: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 107 bits (266), Expect = 8e-23
Identities = 60/176 (34%), Positives = 92/176 (52%)
Query: 840 QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899
Q + + +++C LT+ C+ ++S LR + L L+L N L D G + L C +Q
Sbjct: 29 QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
Query: 900 RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959
+L L+ C LT C + S L TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 89 KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
LE C ++ C+ +AS+LR + L +S N I G+ LC+ + E +
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
Score = 74.3 bits (181), Expect = 6e-13
Identities = 47/126 (37%), Positives = 62/126 (49%)
Query: 888 WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947
W L L Q + L C LT C+D+ SAL N L L+L N L D GV + +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 948 LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007
L+ P C +Q L L+NC T C ++S LR L+ L LS N +G G+ LCE
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 1008 QKKREE 1013
+ R E
Sbjct: 140 PQCRLE 145
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 161 bits (408), Expect = 3e-39
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)
Query: 695 LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753
L S T L+ L +++++LG L+ L L PQC+L+KL L + + + + L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 754 VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813
VL + L + + ++ V++LC+ L+ C+L+ L+LE C T DL +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 814 GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867
L+ L L N L E C ++L L I C +T C L LR +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 868 MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
L LSLA N L DEGA+ + L C L+ L ++ C T CC S L +N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
L +S N L+D GV LC+ L P L++L L +C + C ++A+ L N LR LD
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 988 LSKNAIGVYGILTLCEA 1004
LS N +G GIL L E+
Sbjct: 405 LSNNCLGDAGILQLVES 421
Score = 149 bits (375), Expect = 2e-35
Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
+D+ S N L L + ++ LG + + L+ P CK+QKL L+ + L
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
Query: 753 GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
GVL+ L+ L + + ++LLC L P+CRL+ L+LE C + L
Sbjct: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
Query: 809 GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862
+ L+ K L + N + G L S QLE L +E+C +T C L
Sbjct: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
Query: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922
+ L L+L N L D G + L H L+ L + +C +T C D+ L
Sbjct: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
Query: 923 NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982
++LK L L+ N L D+G LLCE L P C L+ L +++C FT+ CC +S+L +N+
Sbjct: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
Query: 983 LRHLDLSKNAIGVYGILTLCE 1003
L L +S N + G+ LC+
Sbjct: 343 LLELQISNNRLEDAGVRELCQ 363
Score = 118 bits (295), Expect = 3e-26
Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)
Query: 791 QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844
Q +RL+DC T D+ + L+ N L L LR N L + G + + ++++L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 845 SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904
S++NC LT C L+S LR L L L++N L D G + + L +C L++L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
Query: 905 KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964
C L+ C+ + S L K L +S N + + GV +LC+ LK+ C L+ L+LE+C
Sbjct: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
Query: 965 FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002
TS C+ + ++ LR L L N +G G+ LC
Sbjct: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
Score = 118 bits (295), Expect = 3e-26
Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)
Query: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
+ L SV + LT++N+ + ++ L L+ C+L+ L L T N +DL
Sbjct: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
Query: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
G++ LR L + ++ + LC L P RL+ L + +C T + DL
Sbjct: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
Query: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
L+ LK L L N L + GA L QLE L +++C+ T C +S L Q
Sbjct: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
Query: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
++ L L ++ N L+D G + + L L+ L L CD++ + C + + L N +
Sbjct: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
Query: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 107 bits (266), Expect = 8e-23
Identities = 60/176 (34%), Positives = 92/176 (52%)
Query: 840 QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899
Q + + +++C LT+ C+ ++S LR + L L+L N L D G + L C +Q
Sbjct: 29 QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
Query: 900 RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959
+L L+ C LT C + S L TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 89 KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
LE C ++ C+ +AS+LR + L +S N I G+ LC+ + E +
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
Score = 74.3 bits (181), Expect = 6e-13
Identities = 47/126 (37%), Positives = 62/126 (49%)
Query: 888 WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947
W L L Q + L C LT C+D+ SAL N L L+L N L D GV + +
Sbjct: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
Query: 948 LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007
L+ P C +Q L L+NC T C ++S LR L+ L LS N +G G+ LCE
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 1008 QKKREE 1013
+ R E
Sbjct: 140 PQCRLE 145
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,319,142
Number of Sequences: 37866
Number of extensions: 1901953
Number of successful extensions: 5797
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 59
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 4861
Number of HSP's gapped (non-prelim): 385
length of query: 1048
length of database: 18,247,518
effective HSP length: 113
effective length of query: 935
effective length of database: 13,968,660
effective search space: 13060697100
effective search space used: 13060697100
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.