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Search of human proteins with 33624896
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33624896 ADAM metallopeptidase with thrombospondin type 1
motif, 9 preproprotein [Homo sapiens]
(1935 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 4169 0.0
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 2070 0.0
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 733 0.0
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 667 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 650 0.0
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 632 e-180
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 596 e-170
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 575 e-163
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 567 e-161
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 556 e-158
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 551 e-156
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 550 e-156
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 546 e-154
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 476 e-133
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 469 e-131
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 441 e-123
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 440 e-123
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 435 e-121
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 435 e-121
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 389 e-107
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 388 e-107
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 362 3e-99
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 315 3e-85
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 295 2e-79
gi|145309328 papilin [Homo sapiens] 281 4e-75
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 280 7e-75
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 253 1e-66
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 231 5e-60
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 196 2e-49
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 196 2e-49
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 4169 bits (10811), Expect = 0.0
Identities = 1935/1935 (100%), Positives = 1935/1935 (100%)
Query: 1 MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALG 60
MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALG
Sbjct: 1 MQFVSWATLLTLLVRDLAEMGSPDAAAAVRKDRLHPRQVKLLETLSEYEIVSPIRVNALG 60
Query: 61 EPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFI 120
EPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFI
Sbjct: 61 EPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFI 120
Query: 121 APLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD 180
APLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD
Sbjct: 121 APLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHD 180
Query: 181 GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTR 240
GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTR
Sbjct: 181 GDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTR 240
Query: 241 ARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVV 300
ARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVV
Sbjct: 241 ARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVV 300
Query: 301 ADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNA 360
ADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNA
Sbjct: 301 ADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNA 360
Query: 361 QTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSI 420
QTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSI
Sbjct: 361 QTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSI 420
Query: 421 SEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSR 480
SEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSR
Sbjct: 421 SEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSR 480
Query: 481 KYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRR 540
KYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRR
Sbjct: 481 KYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRR 540
Query: 541 LWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTC 600
LWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTC
Sbjct: 541 LWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTC 600
Query: 601 SRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGK 660
SRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGK
Sbjct: 601 SRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGK 660
Query: 661 HFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICV 720
HFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICV
Sbjct: 661 HFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICV 720
Query: 721 QGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNID 780
QGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNID
Sbjct: 721 QGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNID 780
Query: 781 VRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERIN 840
VRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERIN
Sbjct: 781 VRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERIN 840
Query: 841 STDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKR 900
STDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKR
Sbjct: 841 STDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKR 900
Query: 901 KLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDI 960
KLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDI
Sbjct: 901 KLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDI 960
Query: 961 YCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRR 1020
YCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRR
Sbjct: 961 YCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRR 1020
Query: 1021 RAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQ 1080
RAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQ
Sbjct: 1021 RAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQ 1080
Query: 1081 FGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYM 1140
FGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYM
Sbjct: 1081 FGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYM 1140
Query: 1141 SVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK 1200
SVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK
Sbjct: 1141 SVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK 1200
Query: 1201 GTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRAT 1260
GTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRAT
Sbjct: 1201 GTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRAT 1260
Query: 1261 RQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSAS 1320
RQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSAS
Sbjct: 1261 RQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSAS 1320
Query: 1321 PSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACES 1380
PSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACES
Sbjct: 1321 PSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACES 1380
Query: 1381 GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP
Sbjct: 1381 GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
Query: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK
Sbjct: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR 1560
WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR
Sbjct: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR 1560
Query: 1561 AEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGE 1620
AEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGE
Sbjct: 1561 AEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGE 1620
Query: 1621 WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSAT 1680
WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSAT
Sbjct: 1621 WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSAT 1680
Query: 1681 WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCK 1740
WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCK
Sbjct: 1681 WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCK 1740
Query: 1741 EVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNP 1800
EVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNP
Sbjct: 1741 EVKRLKGASEDGEYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNP 1800
Query: 1801 TECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATA 1860
TECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATA
Sbjct: 1801 TECPYNGSRRDDCQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATA 1860
Query: 1861 GDCYSAAKCPQGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCG 1920
GDCYSAAKCPQGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCG
Sbjct: 1861 GDCYSAAKCPQGRFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCG 1920
Query: 1921 KCTPSSGTGLEVRVL 1935
KCTPSSGTGLEVRVL
Sbjct: 1921 KCTPSSGTGLEVRVL 1935
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 2070 bits (5364), Expect = 0.0
Identities = 969/1923 (50%), Positives = 1300/1923 (67%), Gaps = 61/1923 (3%)
Query: 35 HPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSST 94
HPRQ L+ TL+ YE+V P RVN GE FP + HF R +RS + A +P P
Sbjct: 27 HPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHHFSRQKRS-SEALEPMPF--------- 76
Query: 95 SSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEE-EAELKHCFYK 153
+ HYR +A+GQ F NLTA+A F+A +T LGTP + + S+ ++L+HCFY+
Sbjct: 77 --RTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTP--ERGAWESDAGPSDLRHCFYR 132
Query: 154 GYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQ 213
G VN+ ++ AV+SLC G+ GTF+ +G+YF+EP+ D E E+ NKPH+IYR+
Sbjct: 133 GQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNN 192
Query: 214 REPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKT 273
T ++ C SE + + + T + N+ D+ + E + +K
Sbjct: 193 SFLQTLKY-CSVSESQIKETSLPFHTYS-------NMNEDLNVMK-----ERVLGHTSKN 239
Query: 274 DNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSI 333
+++R H R KR +SYPR++E++V AD ++VS HG NLQ+YILTLMSIVA+IYKDPSI
Sbjct: 240 VPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSI 299
Query: 334 GNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLTR 390
GNLI+IV+V L++IH E++GP I+F+ TTLKNFC WQ ++N +H HDTAVL+TR
Sbjct: 300 GNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITR 359
Query: 391 QDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKC 450
+DIC + +KC+ LGL+ LGTICDP +SC I+E+ GL +AFTIAHELGH + HDDN +C
Sbjct: 360 EDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRC 419
Query: 451 KEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQL 510
KE V + HVMAP L+F+ +PW WS CSRKY+TEFLDTGYGECLL++P+ Y LP +L
Sbjct: 420 KEMKV-TKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSEL 478
Query: 511 PGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGK 570
PG Y+ NKQCEL FGPGSQ+CP++ C LWC + +HKGC TQH P ADGT+C PG
Sbjct: 479 PGSRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGM 538
Query: 571 HCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGR 630
HC++G CV KE + +G WG W P+ +CSRTCGGGI++A R CNRPEP+NGG YCVGR
Sbjct: 539 HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGR 598
Query: 631 RMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFC 690
RMKF+SCNT+ C K +DFR++QC+ F+GKH +I+G+ NVRW+P+YSGI KDRCKL+C
Sbjct: 599 RMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYC 658
Query: 691 RVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNS 750
+VAG +Y L+D V DGTPCG +T+DICVQG C AGCDHVLNS A+ DKCGVCGGDNS
Sbjct: 659 QVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNS 718
Query: 751 SCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGN 810
SCKT+ G FN+ HYGYN VV+IPAGATN+D+RQ+S+SG+ DD+YLALS ++G FL NGN
Sbjct: 719 SCKTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQ-PDDSYLALSDAEGNFLFNGN 777
Query: 811 FVVTMAKREIRI--GNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSF 868
F+++ +K+EI + V+EYSGS AVERINST+R E+EL+LQVL VG LYNPDV YSF
Sbjct: 778 FLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSF 837
Query: 869 NIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHIT 928
NIP+E++ F W+ +GPW+ C+K CQG ++R + C +SD VSD+ CD LP P +T
Sbjct: 838 NIPLEERSDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVT 897
Query: 929 EPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN 988
+ C TDC+LRWHV +SECS+QCG GYRTLDI+C KYS +G+T +VDD +C KP
Sbjct: 898 QSCNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPT 957
Query: 989 REKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRC 1048
+E C G C W YS W++CS+SC GG + R + C+N L D++C +VT + C
Sbjct: 958 QELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENC 1017
Query: 1049 SEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
+EF CP W + +WSECLVTCGKG K RQVWCQ D L+D C+ TKP S+ C+ C
Sbjct: 1018 NEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
Query: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
ASWQ GPWG C+ TCG GYQ+R VKC+ +V++D +C+ A+RP+D Q C L C
Sbjct: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
Query: 1169 PAAPETRRSTYSAPR-TQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPR 1227
T + QWR GSWTPCS +CG+GT+ RYVSCRD +ADES CA LPR
Sbjct: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPR 1197
Query: 1228 PVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETD 1287
P +C TPCG+W+A DWS CS +CG G+ TRQV+C+NY ID + CD + P +
Sbjct: 1198 PAEIWDC-FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNY-HQPIDENYCDPEVRPLME 1255
Query: 1288 QDCSMSPCP---QRTPDSGLAQHPFQN---------EDYRPRSASPSRTHVLGGNQWRTG 1335
Q+CS++ CP P S + + + ED + PS + GNQWRTG
Sbjct: 1256 QECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPS----VRGNQWRTG 1311
Query: 1336 PWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECT 1395
PWG+CSS+C+GG Q R VVCQDENG +A+ C KP E + C GPCPQW YGNWGEC+
Sbjct: 1312 PWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECS 1371
Query: 1396 KLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSV 1455
+ CGGGI++RLV+CQ NG+ D +CEI++KPP QC+ HACP D +W PW+SCS
Sbjct: 1372 QTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSA 1431
Query: 1456 SCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGR 1515
SCG+G K R V+C+ + LE C + KP H+ CR RCP WKA +W++CSV+CG
Sbjct: 1432 SCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGS 1491
Query: 1516 GVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEG 1574
GVQQR V C++ G ++ E C+ TRP S+R C C + C+ +C
Sbjct: 1492 GVQQRDVYCRLKGVGQVVEEM-CDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERK 1550
Query: 1575 SRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQ 1634
++++ C D+ +V+ + S + ++C PC Y+ +T + S+C+ CG Y+Q
Sbjct: 1551 DSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQ 1610
Query: 1635 RLVSCSEIYTGKENYEYSYQTTI--NCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVS 1692
R+ C+EI + K++ + + + CP V+ C + C ATW+VG W CSV+
Sbjct: 1611 RITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQC-INSCLHLATWKVGKWSKCSVT 1669
Query: 1693 CGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLKGASEDG 1752
CG+G+M+R V+C+T S LC LKP +K C +C+ CKE++ +DG
Sbjct: 1670 CGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKC-YANDCKSFTTCKEIQVKNHIRKDG 1728
Query: 1753 EYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDD 1812
+Y+L I+G+++KI+CA M+ ++PKEY+TLV G+ ENFSEVYG RL NP +CP+NGSRR+D
Sbjct: 1729 DYYLNIKGRIIKIYCADMYLENPKEYLTLVQGE-ENFSEVYGFRLKNPYQCPFNGSRRED 1787
Query: 1813 CQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQG 1872
C+C + AAG++ F KIRIDLTSMQI TTDL F++T G+ VPFATAGDCYSA +CPQG
Sbjct: 1788 CECDNGHLAAGYTVFSKIRIDLTSMQIKTTDLLFSKTIFGNAVPFATAGDCYSAFRCPQG 1847
Query: 1873 RFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEV 1932
+FSINL GTG+ ++ +A+W++QG+Y I++S DGTR GKCGGYCGKC P TGL +
Sbjct: 1848 QFSINLSGTGMKISSTAKWLTQGSYTSVSIRRSEDGTRFFGKCGGYCGKCLPHMTTGLPI 1907
Query: 1933 RVL 1935
+V+
Sbjct: 1908 QVI 1910
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15 preproprotein [Homo
sapiens]
Length = 950
Score = 733 bits (1893), Expect = 0.0
Identities = 400/965 (41%), Positives = 538/965 (55%), Gaps = 80/965 (8%)
Query: 100 YRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTN 159
++++AF + F +LT +A F+AP F+ LG P T S+ L+ CFY G VN
Sbjct: 55 FQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSD----LRRCFYSGDVNAE 110
Query: 160 SEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTG 219
+ A +SLC G+ G F +Y I PL + + H++ RR P
Sbjct: 111 PDSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGGPSGDP 170
Query: 220 RHACDTSEHKNR---HSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNT 276
C + N + D K R +GE +
Sbjct: 171 TSRCGVASGWNPAILRALDPYKPRRAGFGE-----------------------------S 201
Query: 277 REKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNL 336
R +R R KRF+S PR+VE LVVAD MV +HG +L+HY+LTL++ A +Y+ PSI N
Sbjct: 202 RSRRRSGRAKRFVSIPRYVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNP 261
Query: 337 INIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHH---DTAVLLTRQDI 393
INIV+V ++++ + GP ++ NA TL+NFC WQ N H DTA+L TRQD+
Sbjct: 262 INIVVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDL 321
Query: 394 CRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEE 453
C A CDTLG+A++GT+CDP RSCS+ ED GL +AFT AHELGHVFNMPHD+ C+E
Sbjct: 322 CGA-TTCDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEV 380
Query: 454 -GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPG 512
G H+M+PTL WS CS IT+FLD+G+G+CLL++P S+P LP LPG
Sbjct: 381 FGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQP-SKPISLPEDLPG 439
Query: 513 ILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHC 572
Y +++QCEL FG GS+ CPYM C +LWC C+T+H PWADGT C GK C
Sbjct: 440 ASYTLSQQCELAFGVGSKPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLC 499
Query: 573 KYGFCVPKE-MDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRR 631
G CV + ++ DGSW W P+G CSRTCGGG++ A R+C P P NGGKYC G R
Sbjct: 500 LKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVR 559
Query: 632 MKFKSCNTEPCLKQK--RDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLF 689
+K++SCN EPC + FR+EQC F+G + + N L V WVPKYSG+ +D+CKL
Sbjct: 560 VKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLI 619
Query: 690 CRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDN 749
CR G +Y L +V+DGT C D+ +CVQG C +AGCD L SK R DKCGVCGGDN
Sbjct: 620 CRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDN 679
Query: 750 SSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNG 809
SCK V G F +GYN VV IPAGA++ID+RQ + G DDNYLAL +S+G++LLNG
Sbjct: 680 KSCKKVTGLFTKPMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNG 739
Query: 810 NFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFN 869
+FVV+ +R++ + +++ YSG+ TAVE + ++ I + L ++VLSVGK+ P VRYSF
Sbjct: 740 HFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFY 799
Query: 870 IPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITE 929
+P E + + +SH K +G S+Q+ D DR P
Sbjct: 800 LPKEPREDK---SSH------PKDPRGPSVLHNSVLSLSNQVEQPD---DRPPA------ 841
Query: 930 PCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNR 989
RW S CSA CG G + + C G + C + +P
Sbjct: 842 --------RWVAGSWGPCSASCGSGLQKRAVDCR------GSAGQRTVPACDAAHRPVET 887
Query: 990 EKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCT-HQEKVTIQRC 1048
+ C C T W SAW+ CSKSC G QRR CV +L +C H++ + C
Sbjct: 888 QACGEPCPT--WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
Query: 1049 SEFPC 1053
PC
Sbjct: 946 VLRPC 950
Score = 89.0 bits (219), Expect = 4e-17
Identities = 42/114 (36%), Positives = 57/114 (50%), Gaps = 2/114 (1%)
Query: 1182 PRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQ 1241
P +W GSW PCSA+CG G + R V CR G AC RPV + C PC
Sbjct: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQ-RTVPACDAAHRPVETQACG-EPCPT 896
Query: 1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPC 1295
W+ WS CS +CG+G R + CV + ++ R +C+ P+ C + PC
Sbjct: 897 WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 82.0 bits (201), Expect = 5e-15
Identities = 39/113 (34%), Positives = 60/113 (53%), Gaps = 4/113 (3%)
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTW 1559
+W AG+W CS SCG G+Q+R V C+ G+ C+ RP + C P CP TW
Sbjct: 842 RWVAGSWGPCSASCGSGLQKRAVDCR-GSAGQRTVPACDAAHRPVETQACGEP-CP--TW 897
Query: 1560 RAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W C+K+CG G + R + CV + +C++ ++P + + C L+PC
Sbjct: 898 ELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 81.6 bits (200), Expect = 7e-15
Identities = 36/121 (29%), Positives = 61/121 (50%), Gaps = 2/121 (1%)
Query: 1045 IQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQ 1104
+++ + P +W +G W C +CG G + R V C+ + CD +P Q C
Sbjct: 832 VEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG 891
Query: 1105 QPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPS 1164
+P C +W+ W CS +CG+G+Q R++KC +G ++ + CN +P + C L
Sbjct: 892 EP-CPTWELSAWSPCSKSCGRGFQRRSLKC-VGHGGRLLARDQCNLHRKPQELDFCVLRP 949
Query: 1165 C 1165
C
Sbjct: 950 C 950
Score = 77.4 bits (189), Expect = 1e-13
Identities = 51/164 (31%), Positives = 70/164 (42%), Gaps = 18/164 (10%)
Query: 1282 YIP-ETDQDCSMSPCPQRTP----DSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGP 1336
Y+P E +D S P R P +S L+ N+ +P P+R W G
Sbjct: 799 YLPKEPREDKSSHPKDPRGPSVLHNSVLS---LSNQVEQPDDRPPAR--------WVAGS 847
Query: 1337 WGACSSTCAGGSQRRVVVCQDENGY-TANDCVERIKPDEQRACESGPCPQWAYGNWGECT 1395
WG CS++C G Q+R V C+ G T C +P E +AC PCP W W C+
Sbjct: 848 WGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGE-PCPTWELSAWSPCS 906
Query: 1396 KLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
K CG G + R + C G C + KP + + C C
Sbjct: 907 KSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 75.1 bits (183), Expect = 6e-13
Identities = 38/107 (35%), Positives = 51/107 (47%), Gaps = 2/107 (1%)
Query: 1443 AAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWK 1502
A W G W CS SCG G ++R V C G C +P + C G CP W+
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQAC-GEPCPTWE 898
Query: 1503 AGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDC 1549
AWS CS SCGRG Q+R + C ++ +CN + +P+ C
Sbjct: 899 LSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
Score = 62.4 bits (150), Expect = 4e-09
Identities = 30/85 (35%), Positives = 44/85 (51%), Gaps = 3/85 (3%)
Query: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEY 1614
P W A W C+ +CG G + R V C A CD + RPV+ ++C +PC
Sbjct: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQACG-EPCP- 895
Query: 1615 VWITGEWSECSVTCGKGYKQRLVSC 1639
W WS CS +CG+G+++R + C
Sbjct: 896 TWELSAWSPCSKSCGRGFQRRSLKC 920
Score = 61.2 bits (147), Expect = 9e-09
Identities = 33/114 (28%), Positives = 47/114 (41%), Gaps = 13/114 (11%)
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675
W+ G W CS +CG G ++R V C +T C P C
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDC--------RGSAGQRTVPACDAAHRPVETQACGEPC 894
Query: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQ--PSHLCHTDLKPEERKTC 1727
P TW + W CS SCG G +RS++C+ + + C+ KP+E C
Sbjct: 895 P---TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFC 945
Score = 42.7 bits (99), Expect = 0.003
Identities = 19/50 (38%), Positives = 27/50 (54%), Gaps = 1/50 (2%)
Query: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPS-HLCHTDLKPEERKTC 1727
A W G+WG CS SCG G+ +R+V C + Q + C +P E + C
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQAC 890
Score = 36.6 bits (83), Expect = 0.24
Identities = 20/65 (30%), Positives = 29/65 (44%), Gaps = 1/65 (1%)
Query: 1325 HVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
H + G+ + P+G CS TC GG Q C + E ++ + R+C PCP
Sbjct: 513 HRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRV-KYRSCNLEPCP 571
Query: 1385 QWAYG 1389
A G
Sbjct: 572 SSASG 576
Score = 35.0 bits (79), Expect = 0.71
Identities = 33/132 (25%), Positives = 50/132 (37%), Gaps = 19/132 (14%)
Query: 1366 CVERIKPDEQRACESGPCPQWA-YGNWGECTKLCGGGIRTRLVVCQR---SNGERFPDLS 1421
CVER ++ R S WA + +G C++ CGGG++ C +NG ++
Sbjct: 504 CVERHNLNKHRVDGS-----WAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKY---- 554
Query: 1422 CEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRN----VYCMAKDGSHLE 1477
CE CN CP A+ + C G H V + K
Sbjct: 555 CE--GVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSP 612
Query: 1478 SDYCKHLAKPHG 1489
D CK + + +G
Sbjct: 613 RDKCKLICRANG 624
Score = 34.7 bits (78), Expect = 0.93
Identities = 19/62 (30%), Positives = 28/62 (45%), Gaps = 3/62 (4%)
Query: 999 GGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWK 1057
G W ++ + CS++C GG Q R C N + K +V + C+ PCP
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNP--TPANGGKYCEGVRVKYRSCNLEPCPSSA 574
Query: 1058 SG 1059
SG
Sbjct: 575 SG 576
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 667 bits (1721), Expect = 0.0
Identities = 354/888 (39%), Positives = 509/888 (57%), Gaps = 49/888 (5%)
Query: 101 RLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNS 160
RL AF QQ L ++ F+AP FT+ +G ++T E +L HCFY G VN +
Sbjct: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPL---PETDLAHCFYSGTVNGDP 133
Query: 161 EHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQ-------EDEEEQNKPHIIYRRSAPQ 213
A +SLC G+ G F YFI+PL + E+ E + H++ R
Sbjct: 134 SSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRN---- 189
Query: 214 REPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKT 273
R+ G C + + R + +A E G+ A G T
Sbjct: 190 RQGDVGG-TCGVVDDEPRPTG-----KAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPT 243
Query: 274 DNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSI 333
++ KRF+S R+VE ++VAD M +HG L+HY+LTL S+ A +YK PSI
Sbjct: 244 GTGSIRK-----KRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSI 298
Query: 334 GNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPG---GIHHDTAVLLTR 390
N +++V+V ++VIH+EQ GP ++ NA TL+NFC WQ N P H+DTA+L TR
Sbjct: 299 RNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTR 358
Query: 391 QDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKC 450
QD+C + CDTLG+A++GT+CDP RSCS+ ED GL AFT AHELGHVFNMPHDD +C
Sbjct: 359 QDLCGSQT-CDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQC 417
Query: 451 KE-EGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQ 509
GV H+MA L+ + WS CS IT FLD G+GECL+++P++ P LP
Sbjct: 418 ASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQN-PIQLPGD 476
Query: 510 LPGILYNVNKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWADGTECEP 568
LPG Y+ N+QC+ FG S+ CP C LWC +G C+T+H PWADGT C
Sbjct: 477 LPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGE 536
Query: 569 GKHCKYGFCVPK----EMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGG 624
GK C G CV K D P GSWG W P+G CSRTCGGG++ +REC+ P PKNGG
Sbjct: 537 GKWCINGKCVNKTDRKHFDTPF-HGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGG 595
Query: 625 KYCVGRRMKFKSCNTEPCLKQK-RDFRDEQC-AHFDGKHFNINGLLPNVRWVPKYSGILM 682
KYC G+R++++SCN E C + FR+EQC AH + + G P V W+PKY+G+
Sbjct: 596 KYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASF-GSGPAVEWIPKYAGVSP 654
Query: 683 KDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKC 742
KDRCKL C+ G ++ L+ +V+DGTPC D+ +CVQG C +AGCD +++SK + DKC
Sbjct: 655 KDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKC 714
Query: 743 GVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSK 802
GVCGG+ S+CK ++G+ + GY+ ++ IP GATNI+V+Q + G ++ ++LA+ ++
Sbjct: 715 GVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD 774
Query: 803 GEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNP 862
G ++LNG++ ++ +++I V+ YSGS A+ERI S +++ L +QVL+VG P
Sbjct: 775 GTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRP 834
Query: 863 DVRYSFNIPIEDK-----PQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQR 917
++Y++ + + + P W W CSK C+ +R+LV R+ + S+
Sbjct: 835 KIKYTYFVKKKKESFNAIPTFSAWVIE-EWGECSKSCELGWQRRLVECRDINGQPASE-- 891
Query: 918 CDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKY 965
C + +P T PC +W + S CS CG GY+ + C +
Sbjct: 892 CAKEVKPAS-TRPCADHPCPQWQLGEWSSCSKTCGKGYKKRSLKCLSH 938
Score = 96.7 bits (239), Expect = 2e-19
Identities = 41/97 (42%), Positives = 53/97 (54%)
Query: 1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNW 1391
W WG CS +C G QRR+V C+D NG A++C + +KP R C PCPQW G W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
Query: 1392 GECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP 1428
C+K CG G + R + C +G SC+ L KP
Sbjct: 918 SSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 86.7 bits (213), Expect = 2e-16
Identities = 45/119 (37%), Positives = 62/119 (52%), Gaps = 7/119 (5%)
Query: 1178 TYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVT 1237
T+SA W W CS +C G + R V CRD NG A E CA +P + C+
Sbjct: 854 TFSA----WVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKPASTRPCADH 907
Query: 1238 PCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD-CSMSPC 1295
PC QW+ +WSSCS TCG+G R + C+++ V+ CD P+ D C+M+ C
Sbjct: 908 PCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 84.0 bits (206), Expect = 1e-15
Identities = 44/112 (39%), Positives = 58/112 (51%), Gaps = 5/112 (4%)
Query: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQR-CSEFPCPQWKSG 1059
W W ECSKSC+ G QRR C + S+C + K R C++ PCPQW+ G
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPCADHPCPQWQLG 915
Query: 1060 DWSECLVTCGKGHKHRQVWCQFGEDR-LNDRMCDPETKPTS-MQTCQQPECA 1109
+WS C TCGKG+K R + C + L+ CDP KP + C EC+
Sbjct: 916 EWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAECS 967
Score = 74.7 bits (182), Expect = 8e-13
Identities = 37/105 (35%), Positives = 58/105 (55%), Gaps = 11/105 (10%)
Query: 1604 RESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQ 1663
+ES + P W+ EW ECS +C G+++RLV C +I G+ E + + +
Sbjct: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDI-NGQPASECAKE-------VK 897
Query: 1664 PPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNE 1708
P S PC CP W++G W SCS +CG G +RS++CL+++
Sbjct: 898 PASTRPCADHPCP---QWQLGEWSSCSKTCGKGYKKRSLKCLSHD 939
Score = 74.3 bits (181), Expect = 1e-12
Identities = 35/108 (32%), Positives = 52/108 (48%), Gaps = 2/108 (1%)
Query: 1437 HACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGG 1496
+A P +AW W CS SC G ++R V C +G + C KP R C
Sbjct: 850 NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADH 907
Query: 1497 RCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPE 1544
CP+W+ G WS CS +CG+G ++R + C + C+P +P+
Sbjct: 908 PCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPK 955
Score = 72.8 bits (177), Expect = 3e-12
Identities = 35/81 (43%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWIT 1618
W EEW EC+K+C G + R V C D N + C +P C+ PC W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPCADHPCPQ-WQL 914
Query: 1619 GEWSECSVTCGKGYKQRLVSC 1639
GEWS CS TCGKGYK+R + C
Sbjct: 915 GEWSSCSKTCGKGYKKRSLKC 935
Score = 72.4 bits (176), Expect = 4e-12
Identities = 37/123 (30%), Positives = 57/123 (46%), Gaps = 21/123 (17%)
Query: 1106 PECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
P ++W WG+CS +C G+Q R V+C ++ ++C +P T+ C +
Sbjct: 853 PTFSAWVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECAKEVKPASTRPC---AD 906
Query: 1166 HPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATL 1225
HP P QW+ G W+ CS TCGKG + R + C +G V +C L
Sbjct: 907 HPCP---------------QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPL 951
Query: 1226 PRP 1228
+P
Sbjct: 952 KKP 954
Score = 70.5 bits (171), Expect = 2e-11
Identities = 36/111 (32%), Positives = 51/111 (45%), Gaps = 3/111 (2%)
Query: 1056 WKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGP 1115
W +W EC +C G + R V C+ + C E KP S + C C WQ G
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASE-CAKEVKPASTRPCADHPCPQWQLGE 916
Query: 1116 WGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQD-CELPSC 1165
W CS TCG+GY+ R++KC + V+ C+ +P D C + C
Sbjct: 917 WSSCSKTCGKGYKKRSLKC-LSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 69.3 bits (168), Expect = 3e-11
Identities = 37/113 (32%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR 1560
W W +CS SC G Q+R V C+ + A +EC +P S R C CP W+
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPA--SECAKEVKPASTRPCADHPCP--QWQ 913
Query: 1561 AEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVD-RESCSLQPC 1612
EW C+KTCG+G + R + C+ + + CD K+P + C++ C
Sbjct: 914 LGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 50.4 bits (119), Expect = 2e-05
Identities = 32/131 (24%), Positives = 48/131 (36%), Gaps = 37/131 (28%)
Query: 1231 KEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD 1289
KE + P W +W CS +C G R V C + + SEC ++ P + +
Sbjct: 846 KESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRP 903
Query: 1290 CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQ 1349
C+ PCP QW+ G W +CS TC G +
Sbjct: 904 CADHPCP----------------------------------QWQLGEWSSCSKTCGKGYK 929
Query: 1350 RRVVVCQDENG 1360
+R + C +G
Sbjct: 930 KRSLKCLSHDG 940
Score = 46.2 bits (108), Expect = 3e-04
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
P + W + WG CS SC +G +R V+C QP+ C ++KP + C
Sbjct: 853 PTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPC 904
Score = 43.1 bits (100), Expect = 0.003
Identities = 35/140 (25%), Positives = 56/140 (40%), Gaps = 34/140 (24%)
Query: 1340 CSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQ-------------- 1385
CS+ G+ V+VCQ ++ A+ E + C +G C
Sbjct: 506 CSTLWCTGTSGGVLVCQTKHFPWADGT----SCGEGKWCINGKCVNKTDRKHFDTPFHGS 561
Query: 1386 WA-YGNWGECTKLCGGGIRTRLVVCQR---------SNGERFPDLSCEILDKPPD----- 1430
W +G WG+C++ CGGG++ + C G+R SC + D P +
Sbjct: 562 WGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTF 621
Query: 1431 -REQCNTHACPHDAAWSTGP 1449
EQC H A++ +GP
Sbjct: 622 REEQCEAHNEFSKASFGSGP 641
Score = 37.7 bits (86), Expect = 0.11
Identities = 19/48 (39%), Positives = 26/48 (54%), Gaps = 2/48 (4%)
Query: 885 GPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPC 931
G W +CSK C +G +KR L C D +S + CD L +P H + C
Sbjct: 915 GEWSSCSKTCGKGYKKRSLKCL-SHDGGVLSHESCDPLKKPKHFIDFC 961
Score = 35.8 bits (81), Expect = 0.42
Identities = 42/158 (26%), Positives = 53/158 (33%), Gaps = 45/158 (28%)
Query: 985 KPSNREKCSGECNTGGWRYSAWTEC-------SKSC-DGGTQRRRAICVNTRNDVLDDSK 1036
KP N + G+ G Y A +C SK C D + C T VL
Sbjct: 466 KPQNPIQLPGDLP--GTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVL---- 519
Query: 1037 CTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETK 1096
+ + FP W G +CG+G WC G+ C +T
Sbjct: 520 --------VCQTKHFP---WADG------TSCGEGK-----WCINGK-------CVNKTD 550
Query: 1097 PTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKC 1134
T W GPWG CS TCG G Q +C
Sbjct: 551 RKHFDTPFHGSWGMW--GPWGDCSRTCGGGVQYTMREC 586
Score = 32.7 bits (73), Expect = 3.5
Identities = 39/172 (22%), Positives = 56/172 (32%), Gaps = 49/172 (28%)
Query: 1430 DREQCNTHACPHDAAWSTG-------------PWSSCSVSCGRGHKQRNVYCMAK-DGSH 1475
D + C A W TG PW+ SCG G N C+ K D H
Sbjct: 495 DSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWAD-GTSCGEGKWCINGKCVNKTDRKH 553
Query: 1476 LESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARET 1535
++ + G W G W CS +CG GVQ
Sbjct: 554 FDTPF--------------HGSWGMW--GPWGDCSRTCGGGVQY-------------TMR 584
Query: 1536 ECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNK 1587
EC+ + C+G R +R+ ++C G +R+ C N+
Sbjct: 585 ECDNPVPKNGGKYCEGKR---VRYRSCNLEDCPD--NNGKTFREEQCEAHNE 631
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 650 bits (1676), Expect = 0.0
Identities = 410/1126 (36%), Positives = 578/1126 (51%), Gaps = 118/1126 (10%)
Query: 38 QVKLLETLSEYEIVSPIRVNALGEPFPTNVH---FKRTRRSINSATDPWPAFASSSSSST 94
Q + L L Y++ PIRV+ G V R RRS++ DP A
Sbjct: 32 QEEFLTYLEHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPI-DPQQAV-------- 82
Query: 95 SSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKG 154
S+ ++LSA+G+ F NLT N F++ FTV G G + L +C Y G
Sbjct: 83 -SKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDF------LDNCHYTG 135
Query: 155 YVNTNSEHTAV-ISLCSGMLGTFRSHDGDYFIEPLQSM--DEQEDEEEQNKPHIIYRRSA 211
Y+ T V +S C G+ G + D +YFIEPL++ D + E PH+IY++SA
Sbjct: 136 YLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSA 195
Query: 212 PQREPSTGRHACDTSEHKNRHSKDKKKTRARK--WGERINLAGDVAALNSGLATEAFSAY 269
Q+ RH D S H TR+ K W LN +T ++S
Sbjct: 196 LQQ-----RHLYDHS-----HCGVSDFTRSGKPWW------------LND-TSTVSYSLP 232
Query: 270 GNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIY 328
N T H R KR +S RFVE LVVAD MV YHG ++++HYIL++M+IVA +Y
Sbjct: 233 INNT------HIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLY 286
Query: 329 KDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSP----------G 378
+D S+GN++NI++ LIV+ +Q I+ +A +L +FC+WQ S S G
Sbjct: 287 RDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENG 346
Query: 379 GIHHDTAVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELG 437
HHD AVL+TR DIC +K C TLGLA + +C+P RSCSI+ED GL +AFTIAHE+G
Sbjct: 347 IAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIG 406
Query: 438 HVFNMPHDD-NNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLL 496
H F M HD N C +G ++ + +MA + TNP+ WS CSR YIT FLD+G G CL
Sbjct: 407 HNFGMNHDGIGNSCGTKGHEAAK-LMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLD 465
Query: 497 NEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQ 556
NEP R + P PG +Y+ ++QC +G S+ C Y CR LWC + + C T
Sbjct: 466 NEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSN---RCVTN 522
Query: 557 HTPWADGTECEPGK----HCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAI 612
P A+GT C+ G C G CVP DG WG WS +G CSRTCGGG+ +++
Sbjct: 523 SIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSL 582
Query: 613 RECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFD-----GKHFNINGL 667
R C+ P P GGKYC+G R +++SCNT+PC RDFR++QCA FD GK++N
Sbjct: 583 RHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYN---- 638
Query: 668 LPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQA 727
W P Y+G +K C L C G Y + VIDGT C D+ DIC+ G C+
Sbjct: 639 -----WKP-YTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECKHV 691
Query: 728 GCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN--TVHYGYNTVVRIPAGATNIDVRQHS 785
GCD++L S AR D+C VCGGD S+C + G FN GY VV+IP G+ +I+VR+ +
Sbjct: 692 GCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVREVA 751
Query: 786 FSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRI 845
S NY+AL S ++ +NG + + R+ + Y E + +
Sbjct: 752 MS-----KNYIALKSEGDDYYINGAWTIDW-PRKFDVAGTAFHYKRPTDEPESLEALGPT 805
Query: 846 EQELLLQVLSVGKLYNPDVRYSFNIPIE-----DKPQQFYWNSHGPWQACSKPCQ-GERK 899
+ L++ VL + N +RY FN+PI D F WN H PW CS C G ++
Sbjct: 806 SENLIVMVLL--QEQNLGIRYKFNVPITRTGSGDNEVGFTWN-HQPWSECSATCAGGVQR 862
Query: 900 RKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTL 958
+++VC R D V + CD +P C T+ C W + ECS C G RT
Sbjct: 863 QEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTR 922
Query: 959 DIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQ 1018
+ C + + E +D C +H +P +E C+ + W W+EC+ C G +
Sbjct: 923 AVLCIRKIG-PSEEETLDYSGCLTH-RPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFK 980
Query: 1019 RRRAICVNT-RNDVLDDSKCTHQEKVTIQ-RCS--EFPCPQWKSGDWSECLVTCGKGHKH 1074
R +C ++ + ++C + K ++ RCS P P+W +GDW +C CG G +
Sbjct: 981 HRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQM 1040
Query: 1075 RQVWC-QFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQC 1119
R V C + +D C +P SMQ C+ +C S +C
Sbjct: 1041 RTVQCLSYTGQASSD--CLETVRPPSMQQCES-KCDSTPISNTEEC 1083
Score = 167 bits (424), Expect = 7e-41
Identities = 105/278 (37%), Positives = 134/278 (48%), Gaps = 39/278 (14%)
Query: 1329 GNQWRTGPWGACSSTCAGGSQRRVVVCQ--DENGYTAND-CVERIKPDE-QRACESGPCP 1384
G W PW CS+TCAGG QR+ VVC+ D+N N+ C KP E QRAC + PCP
Sbjct: 841 GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCP 900
Query: 1385 -QWAYGNWGECTKLCGGGIRTRLVVCQRSNG---ERFPDLSCEILDKPPDREQCNTHACP 1440
+W G+W EC+K C GG+RTR V+C R G E D S + +P ++E CN +CP
Sbjct: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCP 960
Query: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSH-LESDYCKHLAKPHGHRKCRGGRC- 1498
W WS C+ CG G K R V C + D S + C +KP +C GRC
Sbjct: 961 --PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
Query: 1499 -PKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQG------ 1551
P+W G W QCS CG G Q R V C T + + ++C RP S + C+
Sbjct: 1019 PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS--SDCLETVRPPSMQQCESKCDSTP 1076
Query: 1552 -------------PRCPL-----YTWRAEEWQECTKTC 1571
CPL + RA Q C KTC
Sbjct: 1077 ISNTEECKDVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
Score = 150 bits (380), Expect = 9e-36
Identities = 83/249 (33%), Positives = 124/249 (49%), Gaps = 14/249 (5%)
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQ-IGTHKIARETECNPYTRP-ESERDCQGPRCPLYT 1558
W WS+CS +C GVQ++ V C+ + + I + C+P ++P E++R C CP
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPP-E 902
Query: 1559 WRAEEWQECTKTCGEGSRYRKVVCV---DDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
W +W EC+KTC G R R V+C+ ++ E ++ RPV++E C+ Q C
Sbjct: 903 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQ 962
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP-GTQPPSVHPCYLRD 1674
W+ +WSEC+ CG G+K R+V C K CP ++PP C L
Sbjct: 963 WVALDWSECTPKCGPGFKHRIVLCKSSDLSKT------FPAAQCPEESKPPVRIRCSLGR 1016
Query: 1675 CPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCE 1734
CP W G+WG CS CG+G R+VQCL+ Q S C ++P + C + +
Sbjct: 1017 CP-PPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDST 1075
Query: 1735 LPQNCKEVK 1743
N +E K
Sbjct: 1076 PISNTEECK 1084
Score = 142 bits (359), Expect = 2e-33
Identities = 92/291 (31%), Positives = 121/291 (41%), Gaps = 56/291 (19%)
Query: 1110 SWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPP 1169
+W PW +CS TC G Q + V C S+V +N C+ ++P + Q +C+ P
Sbjct: 843 TWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQR----ACNTEP 898
Query: 1170 AAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADE----SACATL 1225
PE W G W CS TC G R R V C + G +E S C T
Sbjct: 899 CPPE------------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLT- 945
Query: 1226 PRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCVNYS-DHVIDRSECDQDYI 1283
RPV KE C+ C QW ALDWS C+ CG G R V+C + ++C ++
Sbjct: 946 HRPVEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESK 1005
Query: 1284 PETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSST 1343
P CS+ CP PR W TG WG CS+
Sbjct: 1006 PPVRIRCSLGRCPP------------------PR--------------WVTGDWGQCSAQ 1033
Query: 1344 CAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGEC 1394
C G Q R V C G ++DC+E ++P + CES C N EC
Sbjct: 1034 CGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCES-KCDSTPISNTEEC 1083
Score = 141 bits (356), Expect = 5e-33
Identities = 82/233 (35%), Positives = 108/233 (46%), Gaps = 17/233 (7%)
Query: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP-SNREKCSGECN 997
W+ SECSA C G + ++ C RLD + V + +C KP N+ C+ E
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVC---KRLDDNSI-VQNNYCDPDSKPPENQRACNTEPC 899
Query: 998 TGGWRYSAWTECSKSCDGGTQRRRAICVN----TRNDVLDDSKCTHQEKVTIQRCSEFPC 1053
W W ECSK+CDGG + R +C+ + + LD S C V + C+ C
Sbjct: 900 PPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSC 959
Query: 1054 P-QWKSGDWSECLVTCGKGHKHRQVWCQFGE--DRLNDRMCDPETKPTSMQTCQQPECAS 1110
P QW + DWSEC CG G KHR V C+ + C E+KP C C
Sbjct: 960 PPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPP 1019
Query: 1111 --WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCE 1161
W G WGQCS CG G Q+R V+C+ T + +DC RP Q CE
Sbjct: 1020 PRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQA---SSDCLETVRPPSMQQCE 1069
Score = 120 bits (301), Expect = 1e-26
Identities = 76/253 (30%), Positives = 107/253 (42%), Gaps = 30/253 (11%)
Query: 993 SGECNTG-GWRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQEKVTIQR--C 1048
SG+ G W + W+ECS +C GG QR+ +C N ++ ++ C K + C
Sbjct: 835 SGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRAC 894
Query: 1049 SEFPCP-QWKSGDWSECLVTCGKGHKHRQVWC--QFG---EDRLNDRMCDPETKPTSMQT 1102
+ PCP +W GDW EC TC G + R V C + G E+ L+ C +P +
Sbjct: 895 NTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH-RPVEKEP 953
Query: 1103 CQQPECA-SWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCE 1161
C C W A W +C+ CG G++ R V C C ++P C
Sbjct: 954 CNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCS 1013
Query: 1162 LPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESA 1221
L C PP +W G W CSA CG G +MR V C G + S
Sbjct: 1014 LGRCPPP----------------RWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQAS--SD 1055
Query: 1222 CATLPRPVAKEEC 1234
C RP + ++C
Sbjct: 1056 CLETVRPPSMQQC 1068
Score = 101 bits (252), Expect = 6e-21
Identities = 58/177 (32%), Positives = 82/177 (46%), Gaps = 12/177 (6%)
Query: 1557 YTWRAEEWQECTKTCGEGSRYRKVVC--VDDNKNEVHGARCDV-SKRPVDRESCSLQPCE 1613
+TW + W EC+ TC G + ++VVC +DDN + V CD SK P ++ +C+ +PC
Sbjct: 842 FTWNHQPWSECSATCAGGVQRQEVVCKRLDDN-SIVQNNYCDPDSKPPENQRACNTEPCP 900
Query: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
W G+W ECS TC G + R V C E Y C +P PC +
Sbjct: 901 PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYS---GCLTHRPVEKEPCNNQ 957
Query: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNE---DQPSHLCHTDLKPEERKTC 1727
CP W +W C+ CG G R V C +++ P+ C + KP R C
Sbjct: 958 SCP--PQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRC 1012
Score = 56.2 bits (134), Expect = 3e-07
Identities = 35/135 (25%), Positives = 57/135 (42%), Gaps = 13/135 (9%)
Query: 1601 PVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP 1660
P+ R + W WSECS TC G +++ V C + + Q P
Sbjct: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRL-----DDNSIVQNNYCDP 883
Query: 1661 GTQPP-SVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL-----TNEDQPSHL 1714
++PP + C CP W +G+W CS +C G+ R+V C+ + E+ +
Sbjct: 884 DSKPPENQRACNTEPCP--PEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYS 941
Query: 1715 CHTDLKPEERKTCRN 1729
+P E++ C N
Sbjct: 942 GCLTHRPVEKEPCNN 956
Score = 38.9 bits (89), Expect = 0.049
Identities = 52/219 (23%), Positives = 75/219 (34%), Gaps = 49/219 (22%)
Query: 1248 SSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQH 1307
+SC T G A + + + S C +DYI D C P
Sbjct: 418 NSCG-TKGHEAAKLMAAHITANTNPFSWSACSRDYITSF-LDSGRGTCLDNEPPK----- 470
Query: 1308 PFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCV 1367
D+ + +P + V ++ +GA S C G R + C ++ N CV
Sbjct: 471 ----RDFLYPAVAPGQ--VYDADEQCRFQYGATSRQCKYGEVCRELWCLSKS----NRCV 520
Query: 1368 ERIKPD-----------EQRACESGPC------PQWAYGNWG------ECTKLCGGGIRT 1404
P E+ C G C PQ G WG EC++ CGGG+ +
Sbjct: 521 TNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCGGGVSS 580
Query: 1405 RLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACP 1440
L C S G ++ L + CNT CP
Sbjct: 581 SLRHCDSPAPSGGGKY------CLGERKRYRSCNTDPCP 613
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 632 bits (1629), Expect = e-180
Identities = 348/872 (39%), Positives = 501/872 (57%), Gaps = 88/872 (10%)
Query: 102 LSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSE 161
LSAFG+ F+ L + F+AP F + LG G + E L+ CF+ G VN E
Sbjct: 57 LSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRA-----TGGERGLRGCFFSGTVNGEPE 111
Query: 162 HTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRS---------AP 212
A +SLC G+ G+F ++ I+P Q +PH + R P
Sbjct: 112 SLAAVSLCRGLSGSFLLDGEEFTIQP------QGAGGSLAQPHRLQRWGPAGARPLPRGP 165
Query: 213 QREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNK 272
+ E TG + + H +D ++ + E A+E G
Sbjct: 166 EWEVETGE---GQRQERGDHQEDSEEESQEEEAEG--------------ASEPPPPLGAT 208
Query: 273 TDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPS 332
+ RTKRF+S RFVE L+VAD M +++G +LQ++ILTLMS+ A IYK PS
Sbjct: 209 S----------RTKRFVSEARFVETLLVADASMAAFYGADLQNHILTLMSVAARIYKHPS 258
Query: 333 IGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLT 389
I N IN+++V ++++ +E+ GP +S N TL+NFC WQ N P H +DTA+LLT
Sbjct: 259 IKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLT 318
Query: 390 RQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNK 449
RQ+ C CDTLG+A++GTICDP +SCS+ ED GL A T+AHELGHV +MPHDD+
Sbjct: 319 RQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKP 378
Query: 450 CKEE-GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPV 508
C G HVMAP WS CS Y+TE LD G+G+CLL+ P + PLP
Sbjct: 379 CTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAPAAA-LPLPT 437
Query: 509 QLPG--ILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQH--TPWA 561
LPG LY +++QC IFGP + CP C +LWC+ +G C T++ PWA
Sbjct: 438 GLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHT-DGAEPLCHTKNGSLPWA 496
Query: 562 DGTECEPGKHCKYGFCVPKE---MDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
DGT C PG C G C+P+E PV DG W W P+G CSRTCGGG++ + REC P
Sbjct: 497 DGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDP 556
Query: 619 EPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHF-NINGLLPNVRWVPKY 677
EP+NGG+YC+GRR K++SC+TE C + FR++QC ++ ++ +++G L ++WVPKY
Sbjct: 557 EPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNL--LQWVPKY 614
Query: 678 SGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKA 737
+G+ +DRCKLFCR G + + +VIDGT CG +T ICV+G C +AGCDHV++S
Sbjct: 615 AGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPR 674
Query: 738 RRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLA 797
+ DKCGVCGG +SC+ V+G+ +YGYN +V IPAGATNIDV+Q S G +D NYLA
Sbjct: 675 KLDKCGVCGGKGNSCRKVSGSLTPTNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLA 734
Query: 798 LSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSV- 856
L ++ G++LLNGN ++ +++I + +++YSGS +ER+ S + + L +Q+L+V
Sbjct: 735 LKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVP 794
Query: 857 GKLYNPDVRYSFNIP------IEDKPQQFYWN----------SHGPWQACSKPC-QGERK 899
G+++ P V+Y+F +P ++ ++ N G W CS C G ++
Sbjct: 795 GEVFPPKVKYTFFVPNDVDFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQR 854
Query: 900 RKLVCTRESDQLTVSDQRCDRLPQPGHITEPC 931
R + C S Q + + C++ +P +PC
Sbjct: 855 RTVECRDPSGQASAT---CNKALKP-EDAKPC 882
Score = 62.4 bits (150), Expect = 4e-09
Identities = 25/54 (46%), Positives = 33/54 (61%)
Query: 1331 QWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
QW G W CSSTC G QRR V C+D +G + C + +KP++ + CES CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 52.4 bits (124), Expect = 4e-06
Identities = 21/51 (41%), Positives = 30/51 (58%)
Query: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRN 1729
A W +G+W CS +CG G +R+V+C Q S C+ LKPE+ K C +
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCES 884
Score = 48.9 bits (115), Expect = 5e-05
Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 1385 QWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
QW G+W EC+ CG G + R V C+ +G+ +C KP D + C + CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLCP 888
Score = 48.5 bits (114), Expect = 6e-05
Identities = 21/57 (36%), Positives = 32/57 (56%), Gaps = 2/57 (3%)
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPL 1556
+W G WS+CS +CG G Q+R V C+ + + + CN +PE + C+ CPL
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS--ATCNKALKPEDAKPCESQLCPL 889
Score = 48.1 bits (113), Expect = 8e-05
Identities = 23/57 (40%), Positives = 28/57 (49%), Gaps = 3/57 (5%)
Query: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
A W G W +CS TCG G+Q R V+C S CN A +P D + CE C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVEC---RDPSGQASATCNKALKPEDAKPCESQLC 887
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/80 (33%), Positives = 37/80 (46%), Gaps = 2/80 (2%)
Query: 1029 NDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLND 1088
NDV D S + +E+ T QW GDWSEC TCG G + R V C+ + +
Sbjct: 810 NDV-DFSMQSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS- 867
Query: 1089 RMCDPETKPTSMQTCQQPEC 1108
C+ KP + C+ C
Sbjct: 868 ATCNKALKPEDAKPCESQLC 887
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/63 (34%), Positives = 32/63 (50%), Gaps = 10/63 (15%)
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINC-PGTQPPSVHPCYLRD 1674
W+ G+WSECS TCG G+++R V C + S Q + C +P PC +
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECR---------DPSGQASATCNKALKPEDAKPCESQL 886
Query: 1675 CPV 1677
CP+
Sbjct: 887 CPL 889
Score = 46.2 bits (108), Expect = 3e-04
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 2/57 (3%)
Query: 1443 AAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCP 1499
A W G WS CS +CG G ++R V C +D S S C KP + C CP
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVEC--RDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 45.8 bits (107), Expect = 4e-04
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 2/55 (3%)
Query: 1185 QWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPC 1239
QW G W+ CS+TCG G + R V CRD +G + + C +P + C C
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQAS--ATCNKALKPEDAKPCESQLC 887
Score = 41.6 bits (96), Expect = 0.008
Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W +W EC+ TCG G + R V C D + A C+ + +P D + C Q C
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLC 887
Score = 41.2 bits (95), Expect = 0.010
Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 1241 QWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCP 1296
QW DWS CS TCG G R V C + S + C++ PE + C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLCP 888
Score = 40.8 bits (94), Expect = 0.013
Identities = 65/240 (27%), Positives = 89/240 (37%), Gaps = 45/240 (18%)
Query: 1449 PWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQ 1508
PW+ CG GH + +GS L + + KP GG P W G W +
Sbjct: 494 PWAD-GTPCGPGH-------LCSEGSCLPEEEVER-PKPVAD----GGWAP-W--GPWGE 537
Query: 1509 CSVSCGRGVQQRHVGCQI------GTHKIARET--------ECNPYTRPESERDCQGPRC 1554
CS +CG GVQ H C+ G + + R EC P + E+ C+
Sbjct: 538 CSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNA 597
Query: 1555 PLYT-WRAEEWQECTKTCGEGSRYR-KVVCVDDNKNE--------VHGARCDVSKRPV-D 1603
YT Q K G R R K+ C ++E + G C +
Sbjct: 598 YNYTDMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICV 657
Query: 1604 RESCSLQPCEYVWIT-GEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGT 1662
R C C++V + + +C V GKG R VS S T NY Y+ TI T
Sbjct: 658 RGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTPT---NYGYNDIVTIPAGAT 714
Score = 40.8 bits (94), Expect = 0.013
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 16/79 (20%)
Query: 1367 VERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVC---QRSNGERFPDLSCE 1423
VER KP + G P +G WGEC++ CGGG++ C + NG R+
Sbjct: 518 VERPKP----VADGGWAP---WGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY------ 564
Query: 1424 ILDKPPDREQCNTHACPHD 1442
L + + C+T CP D
Sbjct: 565 CLGRRAKYQSCHTEECPPD 583
Score = 36.2 bits (82), Expect = 0.32
Identities = 23/67 (34%), Positives = 27/67 (40%), Gaps = 14/67 (20%)
Query: 1068 CGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGY 1127
CG GH C G C PE + + A W GPWG+CS TCG G
Sbjct: 501 CGPGHL-----CSEGS-------CLPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGV 546
Query: 1128 QLRAVKC 1134
Q +C
Sbjct: 547 QFSHREC 553
Score = 35.4 bits (80), Expect = 0.54
Identities = 27/98 (27%), Positives = 39/98 (39%), Gaps = 21/98 (21%)
Query: 1335 GPWGACSSTCAGGSQRRVVVCQD---ENGYTANDCVERIKPDEQRACESGPCPQWAYGNW 1391
GPWG CS TC GG Q C+D +NG C+ R + ++C + CP
Sbjct: 533 GPWGECSRTCGGGVQFSHRECKDPEPQNG--GRYCLGR--RAKYQSCHTEECPP------ 582
Query: 1392 GECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPP 1429
G R C++ N + D+ +L P
Sbjct: 583 --------DGKSFREQQCEKYNAYNYTDMDGNLLQWVP 612
Score = 32.0 bits (71), Expect = 6.0
Identities = 24/85 (28%), Positives = 31/85 (36%), Gaps = 20/85 (23%)
Query: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPS-----------HLCHTDLKPEERKTC 1727
A W G WG CS +CG GV +C E Q CHT+ P + K+
Sbjct: 530 APW--GPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSF 587
Query: 1728 RNVYNCELPQNCKEVKRLKGASEDG 1752
R Q C++ DG
Sbjct: 588 RE-------QQCEKYNAYNYTDMDG 605
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 596 bits (1537), Expect = e-170
Identities = 387/1201 (32%), Positives = 591/1201 (49%), Gaps = 127/1201 (10%)
Query: 47 EYEIVSPIRVNALGEPFPTNV-HFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAF 105
+Y V+P+ V++ G ++ H R +RS +A S HYR SAF
Sbjct: 60 DYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNAR---------------SSLHYRFSAF 104
Query: 106 GQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAV 165
GQ+ L +A ++ F V +LG G ++T ++ E++ CFY+G++ +S +
Sbjct: 105 GQELHLELKPSA-ILSSHFIVQVLGKDGASET-----QKPEVQQCFYQGFIRNDSSSSVA 158
Query: 166 ISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQ---NKPHIIYRRSAPQR------EP 216
+S C+G+ G R+ ++ I PL + QE + PH++Y+R+A ++ P
Sbjct: 159 VSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYP 218
Query: 217 STGRHACDTSEHKNRHSKDKKKT-----RARKW---GERINLAGDVAALNSGLATEAFSA 268
+GR+ S H+ ++T R +K G R A ++ L + + +
Sbjct: 219 GSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGS 278
Query: 269 YGNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGE-NLQHYILTLMSIVASI 327
G R +R+ ++++ L+ VE LVVAD +MV HG+ N+ YILT+M++V+ +
Sbjct: 279 SG------RPRRSAGKSQKGLN----VETLVVADKKMVEKHGKGNVTTYILTVMNMVSGL 328
Query: 328 YKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVL 387
+KD +IG+ IN+V+V+LI++ E G I+ +A +L +FCQWQ + G HD A+L
Sbjct: 329 FKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAIL 388
Query: 388 LTRQDICR-AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD- 445
LT DIC ++ CDTLG A + +C YRSC+I+ED+GL AFTIAHE GH F M HD
Sbjct: 389 LTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 448
Query: 446 DNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEP-ESRPY 504
+ N C+ K+ ++M+PTL + WS CSR+Y+ +FL T CL++EP ++ Y
Sbjct: 449 EGNPCR----KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQY 504
Query: 505 PLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWA 561
P +LPG +Y+ + QC+ FG +++C C+ LWC+ V H+ C T+ P A
Sbjct: 505 KYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVG--HR-CETKFMPAA 561
Query: 562 DGTECEPGKHCKYGFCVP-KEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEP 620
+GT C C+ G CV E+ G W +WS + CSRTCGGG+K R CN P+P
Sbjct: 562 EGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKP 621
Query: 621 KNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGI 680
+ GG +C G ++ CN PC + DFR +QCA ++ K F G +W P Y+ +
Sbjct: 622 QYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFR--GWF--YQWKP-YTKV 676
Query: 681 LMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRD 740
+DRCKL+C+ ++ + +V DGTPC + ND+C+ G+C GCDH L SKA D
Sbjct: 677 EEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSD 736
Query: 741 KCGVCGGDNSSCKTVAGTFNTVHYG--YNTVVRIPAGATNIDVRQHSFSGETDDDNYLAL 798
CGVC GDNS+CK G + H Y VV IPAGA +I++++ S +YLA+
Sbjct: 737 ACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVS-----SSYLAV 791
Query: 799 SSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGK 858
S ++ L G + + E EY S ER+ + + L+ ++L GK
Sbjct: 792 RSLSQKYYLTGGWSIDW-PGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGK 850
Query: 859 LYNPDVRYSFNI-------PIEDKPQQFYWNSHGPWQACSKPCQGER-KRKLVCTRESDQ 910
NP + + + + P K + W+ CS C G K +C R+ +
Sbjct: 851 --NPGIAWKYALPKVMNGTPPATKRPAYTWSI--VQSECSVSCGGGYINVKAICLRDQN- 905
Query: 911 LTVSDQRCDRLPQPGHITEP--CGT-DCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSR 967
V+ C +P +TEP C C W S CS C G ++ I C +
Sbjct: 906 TQVNSSFCSAKTKP--VTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKP 963
Query: 968 LDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNT 1027
K E V C P+ + C+ W W++CSK+C G ++R +C +
Sbjct: 964 FQ-KEEAVLHSLCPV-STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
Query: 1028 RNDVLDDSKCTH------QEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWC-- 1079
+ L +S+CT QE + RC + QW + WSEC TCG G + R++ C
Sbjct: 1022 AAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSE 1081
Query: 1080 ---QFGEDRLNDRMCDPETKPT--SMQTCQQPEC---------ASWQAGPWGQCSVTCGQ 1125
Q +R C KP +TC + C A W + PW QC+VTCG
Sbjct: 1082 KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGG 1141
Query: 1126 GYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQ 1185
G Q R+V C+ + C +P + C C APE R
Sbjct: 1142 GVQTRSVHCV----QQGRPSSSCLLHQKPPVLRACNTNFC----PAPEKREDPSCVDFFN 1193
Query: 1186 W 1186
W
Sbjct: 1194 W 1194
Score = 150 bits (380), Expect = 9e-36
Identities = 105/340 (30%), Positives = 143/340 (42%), Gaps = 61/340 (17%)
Query: 1062 SECLVTCGKGHKHRQVWCQFGED-RLNDRMCDPETKP-TSMQTCQQPEC-ASWQAGPWGQ 1118
SEC V+CG G+ + + C ++ ++N C +TKP T + C C A W G W
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
Query: 1119 CSVTCGQGYQLRAVKCIIGTYMS---VVDDNDCNAATRPTDTQDCELPSCHPPPAAPETR 1175
CS C G Q R ++C+ V + C +T PT Q C +C P
Sbjct: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST-PTQVQACNSHACPP-------- 993
Query: 1176 RSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECS 1235
QW G W+ CS TCG+G R R + C+ ES C +LPRP +E C
Sbjct: 994 ---------QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCV 1044
Query: 1236 VTPCG-----QWKALDWSSCSVTCGQGRATRQVMC--VNYSDHVIDRSE--CDQDYIPET 1286
+ C QW A WS CS TCG G R++ C + +I E C P
Sbjct: 1045 LGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
Query: 1287 D--QDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTC 1344
D + C+ CP HP N ++ G W + PW C+ TC
Sbjct: 1105 DLEETCNRRACP---------AHPVYN--------------MVAG--WYSLPWQQCTVTC 1139
Query: 1345 AGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
GG Q R V C + G ++ C+ KP RAC + CP
Sbjct: 1140 GGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRACNTNFCP 1178
Score = 150 bits (378), Expect = 2e-35
Identities = 95/306 (31%), Positives = 133/306 (43%), Gaps = 26/306 (8%)
Query: 1451 SSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRK-CRGGRCPK-WKAGAWSQ 1508
S CSVSCG G+ C+ + + S +C KP K C CP W G WS
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
Query: 1509 CSVSCGRGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEW 1564
CS +C G Q R + C + + C P + P + C CP W W
Sbjct: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNSHACP-PQWSLGPW 1000
Query: 1565 QECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC----EYVWITGE 1620
+C+KTCG G R R+++C + ++C RP +E C L C W+
Sbjct: 1001 SQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASS 1060
Query: 1621 WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSV---HPCYLRDCP- 1676
WSECS TCG G ++R + CSE G + ++ C + P++ C R CP
Sbjct: 1061 WSECSATCGLGVRKREMKCSE--KGFQGKLITFPER-RCRNIKKPNLDLEETCNRRACPA 1117
Query: 1677 -----VSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVY 1731
+ A W W C+V+CG GV RSV C+ + +PS C KP + C N
Sbjct: 1118 HPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRAC-NTN 1175
Query: 1732 NCELPQ 1737
C P+
Sbjct: 1176 FCPAPE 1181
Score = 148 bits (373), Expect = 6e-35
Identities = 92/306 (30%), Positives = 132/306 (43%), Gaps = 33/306 (10%)
Query: 1393 ECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQ-CNTHACPHDAAWSTGPWS 1451
EC+ CGGG +C R + C KP + CN +CP A W G WS
Sbjct: 884 ECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP--AYWMPGEWS 941
Query: 1452 SCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHL---AKPHGHRKCRGGRCP-KWKAGAWS 1507
+CS +C G + R + C+ K E L + P + C CP +W G WS
Sbjct: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWS 1001
Query: 1508 QCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYT---WRAEEW 1564
QCS +CGRGV++R + C+ + E++C RPE + C RCP + W A W
Sbjct: 1002 QCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSW 1061
Query: 1565 QECTKTCGEGSRYRKVVCVDDNKN----EVHGARCDVSKRP-------VDRESCSLQPCE 1613
EC+ TCG G R R++ C + RC K+P +R +C P
Sbjct: 1062 SECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVY 1121
Query: 1614 YV---WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
+ W + W +C+VTCG G + R V C + G+ + +PP + C
Sbjct: 1122 NMVAGWYSLPWQQCTVTCGGGVQTRSVHC--VQQGRPSSSCLLH-------QKPPVLRAC 1172
Query: 1671 YLRDCP 1676
CP
Sbjct: 1173 NTNFCP 1178
Score = 147 bits (370), Expect = 1e-34
Identities = 94/342 (27%), Positives = 137/342 (40%), Gaps = 61/342 (17%)
Query: 1238 PCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD-CSMSPCP 1296
P W + S CSV+CG G + +C+ + ++ S C P T+ C+ CP
Sbjct: 874 PAYTWSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
Query: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ 1356
W G W CS CAGG Q R + C
Sbjct: 933 A---------------------------------YWMPGEWSTCSKACAGGQQSRKIQCV 959
Query: 1357 DENGYTANDCVERI-----KPDEQRACESGPCP-QWAYGNWGECTKLCGGGIRTRLVVCQ 1410
+ + + V P + +AC S CP QW+ G W +C+K CG G+R R ++C+
Sbjct: 960 QKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCK 1019
Query: 1411 RSNGERFPDLSCEILDKPPDREQCNTHACPHDA--AWSTGPWSSCSVSCGRGHKQRNVYC 1468
S E P+ C L +P +E C CP ++ W WS CS +CG G ++R + C
Sbjct: 1020 GSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKC 1079
Query: 1469 MAKDGS----HLESDYCKHLAKPH--GHRKCRGGRCPK---------WKAGAWSQCSVSC 1513
K C+++ KP+ C CP W + W QC+V+C
Sbjct: 1080 SEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTC 1139
Query: 1514 GRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
G GVQ R V C + + C + +P R C CP
Sbjct: 1140 GGGVQTRSVHC---VQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
Score = 116 bits (291), Expect = 2e-25
Identities = 76/242 (31%), Positives = 111/242 (45%), Gaps = 23/242 (9%)
Query: 1507 SQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESE-RDCQGPRCPLYTWRAEEWQ 1565
S+CSVSCG G C + + C+ T+P +E + C CP Y W EW
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAY-WMPGEWS 941
Query: 1566 ECTKTCGEGSRYRKVVCVD----DNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEW 1621
C+K C G + RK+ CV + V + C VS P ++C+ C W G W
Sbjct: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST-PTQVQACNSHACPPQWSLGPW 1000
Query: 1622 SECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSAT- 1680
S+CS TCG+G ++R + C + E S T++ P Q C L CP ++
Sbjct: 1001 SQCSKTCGRGVRKRELLCKG--SAAETLPESQCTSLPRPELQ----EGCVLGRCPKNSRL 1054
Query: 1681 -WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVY--NCELPQ 1737
W +W CS +CG+GV +R ++C Q + PE R CRN+ N +L +
Sbjct: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITF----PERR--CRNIKKPNLDLEE 1108
Query: 1738 NC 1739
C
Sbjct: 1109 TC 1110
Score = 49.7 bits (117), Expect = 3e-05
Identities = 30/94 (31%), Positives = 38/94 (40%), Gaps = 12/94 (12%)
Query: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHP--CY 1671
Y W + SECSV+CG GY C + N + C P P C
Sbjct: 876 YTWSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSF-------CSAKTKPVTEPKICN 927
Query: 1672 LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL 1705
CP A W G W +CS +C G R +QC+
Sbjct: 928 AFSCP--AYWMPGEWSTCSKACAGGQQSRKIQCV 959
Score = 37.4 bits (85), Expect = 0.14
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 1551 GPRCPLYTWRA-EEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
GPR W A +W EC++TCG G ++++ C ++ K + G C S R + C++
Sbjct: 584 GPRPIHGQWSAWSKWSECSRTCGGGVKFQERHC-NNPKPQYGGLFCPGSSRIY--QLCNI 640
Query: 1610 QPC 1612
PC
Sbjct: 641 NPC 643
Score = 33.5 bits (75), Expect = 2.1
Identities = 14/29 (48%), Positives = 19/29 (65%), Gaps = 4/29 (13%)
Query: 1379 ESGPCP---QW-AYGNWGECTKLCGGGIR 1403
E GP P QW A+ W EC++ CGGG++
Sbjct: 582 ELGPRPIHGQWSAWSKWSECSRTCGGGVK 610
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 575 bits (1481), Expect = e-163
Identities = 375/1099 (34%), Positives = 536/1099 (48%), Gaps = 105/1099 (9%)
Query: 38 QVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQ 97
Q + L +L YEI P RV+ G + R +R AT S+
Sbjct: 29 QDEFLSSLESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGAT-------------AESR 75
Query: 98 AHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVN 157
Y++++ FL NLT ++ +A +V G+ + + A HC Y G++
Sbjct: 76 LFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGL------AWQRAARPHCLYAGHLQ 129
Query: 158 --TNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQRE 215
++ H A IS C G+ G + + +Y IEPL + E++ PH++Y+RS+ R
Sbjct: 130 GQASTSHVA-ISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSS-LRH 187
Query: 216 PSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDN 275
P AC +D+K + R W R L GN+T+
Sbjct: 188 PHLDT-ACGV--------RDEKPWKGRPWWLRT------------LKPPPARPLGNETE- 225
Query: 276 TREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGE-NLQHYILTLMSIVASIYKDPSIG 334
R KR +S R+VE LVVAD MV+YHG +++ Y+L +M+IVA +++D S+G
Sbjct: 226 ----RGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLG 281
Query: 335 NLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQ--------HSKNSP--GGIHHDT 384
+ +NI++ LI++ +Q I+ +A +L +FC+WQ H P G +HDT
Sbjct: 282 STVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDT 341
Query: 385 AVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMP 443
AVL+TR DIC +K C TLGLA +G +C+ RSCS++ED GL+TAFTIAHE+GH F M
Sbjct: 342 AVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMN 401
Query: 444 HDD-NNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR 502
HD N C G + P +MA + TNP++WS CSR YIT FLD+G G CL N P +
Sbjct: 402 HDGVGNSCGARG-QDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ 460
Query: 503 PYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWAD 562
+ P PG Y+ ++QC G S+ C Y C LWC + + C T P A+
Sbjct: 461 DFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSN---RCITNSIPAAE 517
Query: 563 GTECEPGK----HCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
GT C+ C CVP DG+WG W+P+G CSRTCGGG+ ++ R C+ P
Sbjct: 518 GTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
Query: 619 EPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYS 678
P GGKYC+G R + +SCNT+ C +DFR+ QC+ FD F +W Y
Sbjct: 578 RPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFDSIPFRGK----FYKW-KTYR 632
Query: 679 GILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKAR 738
G +K C L C G Y + V+DGTPC DT DICV G C+ GCD VL S R
Sbjct: 633 GGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLR 691
Query: 739 RDKCGVCGGDNSSCKTVAGTFNTVH--YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYL 796
DKC VCGGD S+C+T+ G F+ GY VV IP G+ +I ++ + S ++L
Sbjct: 692 EDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLS-----LSHL 746
Query: 797 ALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSV 856
AL + LL G T + + + V+ + + I L++ VL+
Sbjct: 747 ALKGDQESLLLEG-LPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLAR 805
Query: 857 GKLYNPDVRYSFNIPI-EDKPQQFYWNSHGPWQACSKPCQGERKRKLV-CTRESDQLTVS 914
+L P +RY FN PI D + W+ + PW CS C G + + V C + D V+
Sbjct: 806 TEL--PALRYRFNAPIARDSLPPYSWH-YAPWTKCSAQCAGGSQVQAVECRNQLDSSAVA 862
Query: 915 DQRC---DRLP--QPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLD 969
C +LP Q TEPC D W V + S CS C G R+ + C + R+
Sbjct: 863 PHYCSAHSKLPKRQRACNTEPCPPD----WVVGNWSLCSRSCDAGVRSRSVVCQR--RVS 916
Query: 970 GKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNT-R 1028
EK D P+P E C G W W+EC+ SC G + R +C +
Sbjct: 917 AAEEKALDDSACPQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADH 976
Query: 1029 NDVLDDSKCTHQEK-VTIQRCSEFPCP--QWKSGDWSECLVTCGKGHKHRQVWCQFGEDR 1085
L + C+ K RC+ CP +W +G+W EC CG G + R V C +
Sbjct: 977 RATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQ 1036
Query: 1086 LNDRMCDPETKPTSMQTCQ 1104
+ C +P + Q C+
Sbjct: 1037 ASHE-CTEALRPPTTQQCE 1054
Score = 168 bits (426), Expect = 4e-41
Identities = 188/696 (27%), Positives = 253/696 (36%), Gaps = 158/696 (22%)
Query: 1006 WTECSKS-----CDGGTQRRRAICVNTRNDVLD--------------DSKCTHQEKVTIQ 1046
W+ CS+ D G +C+N R D D +C Q V +
Sbjct: 433 WSSCSRDYITSFLDSGL----GLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSR 488
Query: 1047 RCS--EFPCPQWKSGDWSECLV--------TCGKGHKHRQVWCQFGEDRLNDRMCDP-ET 1095
+C E W + C+ T + H + WC R+C P +
Sbjct: 489 QCKYGEVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCY-------KRVCVPFGS 541
Query: 1096 KPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKC------IIGTYM--SVVDDND 1147
+P + P W PWG CS TCG G + C I G Y
Sbjct: 542 RPEGVDGAWGP----WT--PWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRS 595
Query: 1148 CNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYV 1207
CN P +QD C + P R + +T +R G CS TC Y
Sbjct: 596 CNTDDCPPGSQDFREVQCSEFDSIPF--RGKFYKWKT-YRGGGVKACSLTCLAEGFNFYT 652
Query: 1208 SCRDENGSVADESACATLPRPVAKE-ECSVTPCGQWKALDW--SSCSVTCGQGRATRQVM 1264
+ +V D + C + EC C + D C V G G A +
Sbjct: 653 ---ERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIE 709
Query: 1265 CVNYSDHVIDRSECDQDYIPETD-----QDCSMS---------------------PCPQR 1298
V +S D +IP+ QD ++S P P R
Sbjct: 710 GV-FSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHR 768
Query: 1299 TPDSG----LAQHPFQNEDY-----------------------RPRSASPSRTHVLGGNQ 1331
P +G L Q P Q + R R +P L
Sbjct: 769 LPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPPYS 828
Query: 1332 WRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIK-PDEQRACESGPCP-QW 1386
W PW CS+ CAGGSQ + V C+ D + + C K P QRAC + PCP W
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPDW 888
Query: 1387 AYGNWGECTKLCGGGIRTRLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACPHDA 1443
GNW C++ C G+R+R VVCQR + E+ D S +PP E C+ CP +
Sbjct: 889 VVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPE- 947
Query: 1444 AWSTGPWSSCSVSCGRGHKQRNVYCMAKD-GSHLESDYCKHLAKPHGHRKCRGGRCP--K 1500
W+ WS C+ SCG G + R V C + D + L +C AKP +C RCP +
Sbjct: 948 -WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPPAR 1006
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQ---------- 1550
W AG W +CS CG G +QR V C +H EC RP + + C+
Sbjct: 1007 WVAGEWGECSAQCGVGQRQRSVRCT--SHTGQASHECTEALRPPTTQQCEAKCDSPTPGD 1064
Query: 1551 GPR----------CPL-----YTWRAEEWQECTKTC 1571
GP CPL + RA Q C KTC
Sbjct: 1065 GPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
Score = 150 bits (379), Expect = 1e-35
Identities = 84/241 (34%), Positives = 114/241 (47%), Gaps = 17/241 (7%)
Query: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPK-PSNREKCSGECN 997
WH A ++CSAQC G + + C ++LD V +CS+H K P + C+ E
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECR--NQLDSSA--VAPHYCSAHSKLPKRQRACNTEPC 884
Query: 998 TGGWRYSAWTECSKSCDGGTQRRRAICVN----TRNDVLDDSKCTHQEKVTIQRCSEFPC 1053
W W+ CS+SCD G + R +C LDDS C ++ C C
Sbjct: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTC 944
Query: 1054 P-QWKSGDWSECLVTCGKGHKHRQVWCQFGEDR--LNDRMCDPETKPTSMQTCQQPEC-- 1108
P +W + DWSEC +CG G +HR V C+ + R L C P KP + C C
Sbjct: 945 PPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP 1004
Query: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
A W AG WG+CS CG G + R+V+C T + ++C A RP TQ CE P
Sbjct: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---SHECTEALRPPTTQQCEAKCDSPT 1061
Query: 1169 P 1169
P
Sbjct: 1062 P 1062
Score = 135 bits (339), Expect = 5e-31
Identities = 79/256 (30%), Positives = 120/256 (46%), Gaps = 20/256 (7%)
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGC--QIGTHKIARETECNPYTR-PESERDCQGPRCPLY 1557
W W++CS C G Q + V C Q+ + +A C+ +++ P+ +R C CP
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHY-CSAHSKLPKRQRACNTEPCPP- 886
Query: 1558 TWRAEEWQECTKTCGEGSRYRKVVCVDD----NKNEVHGARCDVSKRPVDRESCSLQPCE 1613
W W C+++C G R R VVC + + + C + PV E+C C
Sbjct: 887 DWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPV-LEACHGPTCP 945
Query: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
W +WSEC+ +CG G + R+V C ++ + P +PP+ C LR
Sbjct: 946 PEWAALDWSECTPSCGPGLRHRVVLCKSA-----DHRATLPPAHCSPAAKPPATMRCNLR 1000
Query: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
CP A W G WG CS CGVG QRSV+C ++ Q SH C L+P + C +
Sbjct: 1001 RCP-PARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAKCDS 1059
Query: 1734 ----ELPQNCKEVKRL 1745
+ P+ CK+V ++
Sbjct: 1060 PTPGDGPEECKDVNKV 1075
Score = 94.4 bits (233), Expect = 1e-18
Identities = 55/185 (29%), Positives = 82/185 (44%), Gaps = 13/185 (7%)
Query: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVCVDD-NKNEVHGARCDV-SKRPVDRESCSLQPC 1612
P Y+W W +C+ C GS+ + V C + + + V C SK P + +C+ +PC
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 1613 EYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
W+ G WS CS +C G + R V C + E CP +PP + C+
Sbjct: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSA---CPQPRPPVLEACHG 941
Query: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQ----PSHLCHTDLKPEERKTCR 1728
CP W +W C+ SCG G+ R V C + + + P+H C KP C
Sbjct: 942 PTCP--PEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAH-CSPAAKPPATMRC- 997
Query: 1729 NVYNC 1733
N+ C
Sbjct: 998 NLRRC 1002
Score = 32.3 bits (72), Expect = 4.6
Identities = 17/64 (26%), Positives = 24/64 (37%), Gaps = 3/64 (4%)
Query: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPS---HLCHTDLKPEERKTCRN 1729
RD +W W CS C G ++V+C D + H C K +R+ N
Sbjct: 821 RDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACN 880
Query: 1730 VYNC 1733
C
Sbjct: 881 TEPC 884
Score = 31.6 bits (70), Expect = 7.9
Identities = 47/187 (25%), Positives = 68/187 (36%), Gaps = 42/187 (22%)
Query: 1450 WSSCS-------VSCGRG-------HKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRG 1495
WSSCS + G G +Q VY G ++D R+C+
Sbjct: 433 WSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQCRFQHGVKSRQCKY 492
Query: 1496 GR-CPK-WKAGAWSQC---SVSCGRGVQQRHVGCQIGTHKIAR----ETECNPY-TRPES 1545
G C + W ++C S+ G CQ TH I + + C P+ +RPE
Sbjct: 493 GEVCSELWCLSKSNRCITNSIPAAEGTL-----CQ--THTIDKGWCYKRVCVPFGSRPEG 545
Query: 1546 ERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRE 1605
GP P W +C++TCG G C D + + G C +R
Sbjct: 546 VDGAWGPWTP--------WGDCSRTCGGGVSSSSRHC-DSPRPTIGGKYCLGERR--RHR 594
Query: 1606 SCSLQPC 1612
SC+ C
Sbjct: 595 SCNTDDC 601
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 567 bits (1461), Expect = e-161
Identities = 363/1147 (31%), Positives = 559/1147 (48%), Gaps = 105/1147 (9%)
Query: 47 EYEIVSPIRVNALGEPFPTNV-HFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAF 105
EY++VS V+ G+ + H +R RR++ S H RL
Sbjct: 59 EYDLVSAYEVDHRGDYVSHEIMHHQRRRRAV--------------PVSEVESLHLRLKGS 104
Query: 106 GQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAV 165
F +L ++ +AP F V LG G + E+ CFY+G + ++ +
Sbjct: 105 RHDFHMDLRTSSSLVAPGFIVQTLGKTGTKSVQTLPPED----FCFYQGSLRSHRNSSVA 160
Query: 166 ISLCSGMLGTFRSHDGDYFIEPLQSMDEQE---DEEEQNKPHIIYRRSAPQREPSTGRHA 222
+S C G+ G R+ + DYF+ PL S + + + H++Y+RS P
Sbjct: 161 LSTCQGLSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVL 220
Query: 223 CDTSE----HKNRHSKDKKKTRARKW---GERINLAGDVAALNSGLATEAFSAYGNKTDN 275
+ H+ HS D + +K G R + + + + +
Sbjct: 221 VTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSC------ 274
Query: 276 TREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIG 334
R KR+ R+ R + VE LVV D +M+ HG EN+ Y+LT++++V++++KD +IG
Sbjct: 275 LRHKRSLLRSHR--NEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIG 332
Query: 335 NLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVLLTRQDIC 394
INI IV LI++ +EQ G IS +A TL +FCQWQ G HD A+LLT DIC
Sbjct: 333 GNINIAIVGLILLEDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDIC 392
Query: 395 R-AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKE 452
++ CDTLG A + +C YRSC+I+ED+GL AFTIAHE GH F M HD + N CK
Sbjct: 393 SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCK- 451
Query: 453 EGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPES-RPYPLPVQLP 511
KS ++M+PTL + WS CSR+Y+ +FL T CL ++P+ + Y P +LP
Sbjct: 452 ---KSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLP 508
Query: 512 GILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWADGTECEP 568
G LY+ N QC+ FG +++C + C+ LWC+ + + C T+ P A+GT C
Sbjct: 509 GELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHRIG---RKCETKFMPAAEGTICGH 565
Query: 569 GKHCKYGFCVPKEMDVPV-TDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYC 627
C+ G CV + P T G W WS + CSRTCGGG+ R C P+P +GGK+C
Sbjct: 566 DMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFC 625
Query: 628 VGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCK 687
G K CN++ C + DFR QCA + + F + +W P Y+ + +D CK
Sbjct: 626 EGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGR----HYKWKP-YTQVEDQDLCK 680
Query: 688 LFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGG 747
L+C G ++ L ++V DGTPC +D+ ++C+ G+C + GCD+VL S A D CGVC G
Sbjct: 681 LYCIAEGFDFFFSLSNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNG 740
Query: 748 DNSSCKTVAGTFNTVHY--GYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEF 805
+NS+C G + H+ Y +V IP+GA +I + + + S +Y+++ ++ +
Sbjct: 741 NNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVS-----TSYISVRNALRRY 795
Query: 806 LLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVR 865
LNG++ V R + +Y S E + +T + L++++L G+ NP V
Sbjct: 796 YLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR--NPGVA 852
Query: 866 YSFNIPIEDKPQQFYWNSHGPW----QACSKPCQGERKRKLVCTRESDQLTVSDQRCDRL 921
+ +++P +Q W CS C G + + V+ C+
Sbjct: 853 WEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPK 912
Query: 922 PQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFC 980
+P PC C W V + S CS CG G ++ + C + R+ +E V C
Sbjct: 913 TRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTR--RVHYDSEPVPASLC 970
Query: 981 SSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNT----RNDVLDDSK 1036
P PS+R+ C+ + W W ECS +C G ++R C +T R +L D+
Sbjct: 971 -PQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAV 1029
Query: 1037 CTHQ------EKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQ----FGEDR- 1085
CT + E +QRC + QW WS+C VTC +G + R + C G+ R
Sbjct: 1030 CTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRE 1089
Query: 1086 LNDRMCDPETKPT-------SMQTCQQ--------PECASWQAGPWGQCSVTCGQGYQLR 1130
L + C KP+ + C + P SW A PW QC+ +CG G Q R
Sbjct: 1090 LASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTR 1149
Query: 1131 AVKCIIG 1137
+V+C+ G
Sbjct: 1150 SVQCLAG 1156
Score = 156 bits (394), Expect = 2e-37
Identities = 99/317 (31%), Positives = 134/317 (42%), Gaps = 29/317 (9%)
Query: 1451 SSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKP-HGHRKCRGGRCP-KWKAGAWSQ 1508
S CSVSCG G C + +C +P G C+ CP W G WS
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
Query: 1509 CSVSCGRGVQQRHVGCQIGTHKIARETECN--PYTRPESERDCQGPRCPLYTWRAEEWQE 1566
CS +CG G Q R V C H + + P P S + C CP W A W E
Sbjct: 939 CSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP-AWSAGPWAE 997
Query: 1567 CTKTCGEGSRYRKVVCVDDNKNE----VHGARCDVSKRPVDRESCSLQPC----EYVWIT 1618
C+ TCG+G R R V C N + + A C +P E+C LQ C + W+
Sbjct: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
Query: 1619 GEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP----------GTQPPSVH 1668
WS+CSVTC +G ++R + C+E Y + E + + + P P H
Sbjct: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRH 1117
Query: 1669 PCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCR 1728
P + P +W W C+ SCG GV RSVQCL +P+ C KP C
Sbjct: 1118 PPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAG-GRPASGCLLHQKPSASLAC- 1175
Query: 1729 NVYNCELPQN----CKE 1741
N + C + + CK+
Sbjct: 1176 NTHFCPIAEKKDAFCKD 1192
Score = 150 bits (379), Expect = 1e-35
Identities = 96/306 (31%), Positives = 139/306 (45%), Gaps = 39/306 (12%)
Query: 1340 CSSTCAGGSQRRVVVCQDENGYTAND--CVERIKPDEQRA-CESGPCP-QWAYGNWGECT 1395
CS +C GG C + + N C + +P C+ CP W+ GNW C+
Sbjct: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACS 940
Query: 1396 KLCGGGIRTRLVVCQRS---NGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSS 1452
+ CGGG ++R V C R + E P C P R+ CN+ +CP AWS GPW+
Sbjct: 941 RTCGGGAQSRPVQCTRRVHYDSEPVPASLCP-QPAPSSRQACNSQSCP--PAWSAGPWAE 997
Query: 1453 CSVSCGRGHKQRNVYCMAKDGSH----LESDYCKHLAKPHGHRKCRGGRCPK-----WKA 1503
CS +CG+G ++R V C + + S L C KP H C RC K W
Sbjct: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
Query: 1504 GAWSQCSVSCGRGVQQRHVGCQ----IGTHKIARETECNPYTRP--ESERDCQGPRCPLY 1557
AWSQCSV+C RG Q+R + C G ++ +C+ +P E ER C CP +
Sbjct: 1058 SAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRH 1117
Query: 1558 -----------TWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRES 1606
+W A W +CT +CG G + R V C+ + + C + ++P +
Sbjct: 1118 PPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLA 1174
Query: 1607 CSLQPC 1612
C+ C
Sbjct: 1175 CNTHFC 1180
Score = 149 bits (377), Expect = 2e-35
Identities = 106/343 (30%), Positives = 148/343 (43%), Gaps = 60/343 (17%)
Query: 1062 SECLVTCGKGHKHRQVWCQFG-EDRLNDRMCDPETKP-TSMQTCQQPECA-SWQAGPWGQ 1118
SEC V+CG G + C + ++N C+P+T+P T + C+ C SW G W
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
Query: 1119 CSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRS- 1177
CS TCG G Q R V+C TR +P+ P AP +R++
Sbjct: 939 CSRTCGGGAQSRPVQC-----------------TRRVHYDSEPVPASLCPQPAPSSRQAC 981
Query: 1178 -TYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGS----VADESACATLPRPVAKE 1232
+ S P W G W CS TCGKG R R V+C+ N S + ++ C + P+P E
Sbjct: 982 NSQSCPPA-WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHE 1040
Query: 1233 ECSVTPCG-----QWKALDWSSCSVTCGQGRATRQVMC----VNYSDHVIDRSECDQDYI 1283
C + C QW WS CSVTC +G R + C V+ + +C
Sbjct: 1041 ACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPK 1100
Query: 1284 P--ETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACS 1341
P E ++ C+ PCP+ P + +A PSR W PW C+
Sbjct: 1101 PSLELERACAPLPCPRHPPFA---------------AAGPSR------GSWFASPWSQCT 1139
Query: 1342 STCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
++C GG Q R V C G A+ C+ KP AC + CP
Sbjct: 1140 ASCGGGVQTRSVQCL-AGGRPASGCLLHQKPSASLACNTHFCP 1181
Score = 129 bits (325), Expect = 2e-29
Identities = 94/352 (26%), Positives = 136/352 (38%), Gaps = 79/352 (22%)
Query: 1118 QCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRP-TDTQDCELPSCHPPPAAPETRR 1176
+CSV+CG G C V + + CN TRP T C++ +C P
Sbjct: 880 ECSVSCGGGQMTVREGCYRDLKFQV-NMSFCNPKTRPVTGLVPCKVSACPP--------- 929
Query: 1177 STYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--RDENGSVADESACATLPRPVAKEEC 1234
W G+W+ CS TCG G + R V C R S ++ P P +++ C
Sbjct: 930 --------SWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQAC 981
Query: 1235 SVTPCGQ-WKALDWSSCSVTCGQGRATRQVMCVNYSD----HVIDRSECDQDYIPETDQD 1289
+ C W A W+ CS TCG+G R V C + + ++ + C + P +
Sbjct: 982 NSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEA 1041
Query: 1290 CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQ 1349
C + C ++P+ QW W CS TC G+Q
Sbjct: 1042 CLLQRC------------------HKPKKL-----------QWLVSAWSQCSVTCERGTQ 1072
Query: 1350 RRVVVCQDE------NGYTANDCVERIKP--DEQRACESGPCPQ-------------WAY 1388
+R + C ++ + C KP + +RAC PCP+ W
Sbjct: 1073 KRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFA 1132
Query: 1389 GNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
W +CT CGGG++TR V C P C + KP CNTH CP
Sbjct: 1133 SPWSQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLACNTHFCP 1181
Score = 104 bits (259), Expect = 1e-21
Identities = 67/214 (31%), Positives = 93/214 (43%), Gaps = 21/214 (9%)
Query: 1540 YTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSK 1599
Y+ P + Q P P YTW A EC+ +CG G + C D K +V+ + C+
Sbjct: 855 YSMPRLGTEKQPPAQPSYTW-AIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKT 913
Query: 1600 RPV-DRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTIN 1658
RPV C + C W G WS CS TCG G + R V C T + +Y+
Sbjct: 914 RPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQC----TRRVHYDSEPVPASL 969
Query: 1659 CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQ------PS 1712
CP P S C + CP W G W CS +CG G +R+V C + P
Sbjct: 970 CPQPAPSSRQACNSQSCP--PAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPD 1027
Query: 1713 HLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLK 1746
+C ++ KP + C L Q C + K+L+
Sbjct: 1028 AVCTSEPKPRMHEAC-------LLQRCHKPKKLQ 1054
Score = 38.9 bits (89), Expect = 0.049
Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 13/72 (18%)
Query: 1379 ESGPCP---QWA-YGNWGECTKLCGGGIRTRLVVC---QRSNGERFPDLSCEILDKPPDR 1431
+ GP P W+ + +W C++ CGGG+ R +C + S+G +F + S L
Sbjct: 579 DEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL------ 632
Query: 1432 EQCNTHACPHDA 1443
+ CN+ CP D+
Sbjct: 633 KLCNSQKCPRDS 644
Score = 33.5 bits (75), Expect = 2.1
Identities = 22/88 (25%), Positives = 40/88 (45%), Gaps = 6/88 (6%)
Query: 1550 QGPRCPLYTWRA-EEWQECTKTCGEGSRYRKVVCVDDNKNEVHGAR-CDVSKRPVDRESC 1607
+GP+ W W C++TCG G +R +C N HG + C+ S R + + C
Sbjct: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCT--NPKPSHGGKFCEGSTRTL--KLC 635
Query: 1608 SLQPCEYVWITGEWSECSVTCGKGYKQR 1635
+ Q C + ++C+ + ++ R
Sbjct: 636 NSQKCPRDSVDFRAAQCAEHNSRRFRGR 663
Score = 33.5 bits (75), Expect = 2.1
Identities = 28/111 (25%), Positives = 44/111 (39%), Gaps = 19/111 (17%)
Query: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
H + WS+ WS CS +CG G R+ C SH +C+ + C +CP+
Sbjct: 588 HWSDWSS--WSPCSRTCGGGVSHRSRLCTNPKPSH-GGKFCE--GSTRTLKLCNSQKCPR 642
Query: 1501 WKAG-AWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQ 1550
+QC+ R + RH + PYT+ E + C+
Sbjct: 643 DSVDFRAAQCAEHNSRRFRGRHY-------------KWKPYTQVEDQDLCK 680
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 556 bits (1433), Expect = e-158
Identities = 274/601 (45%), Positives = 378/601 (62%), Gaps = 17/601 (2%)
Query: 283 RRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLINIVIV 342
RR KRF S RFVE LVVAD++M ++HG L+ Y+LT+M+ A +K PSI N +++V+
Sbjct: 208 RRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVT 267
Query: 343 NLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGI---HHDTAVLLTRQDICRAHDK 399
L+++ + ++GP + +A TL++FC WQ N+P H DTA+L TRQD+C
Sbjct: 268 RLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGV-ST 326
Query: 400 CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEEG--VKS 457
CDTLG+A++GT+CDP RSC+I ED GL +AFT AHELGHVFNM HD++ C + +
Sbjct: 327 CDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLST 386
Query: 458 PQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNV 517
+HVMAP + WS CS ++IT+FLD GYG CLL++PE+ P LPV PG Y+
Sbjct: 387 SRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEA-PLHLPVTFPGKDYDA 445
Query: 518 NKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGF 576
++QC+L FGP S+ CP + C LWC+ H C+T+H+PWADGT C P + C G
Sbjct: 446 DRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGR 505
Query: 577 CVP----KEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRM 632
C+ ++ ++P G WG W P+G CSRTCGGG++ + R+C RP P+NGGKYC GRR
Sbjct: 506 CLHMDQLQDFNIPQA-GGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRT 564
Query: 633 KFKSCNTEPC-LKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCR 691
+F+SCNTE C FR+EQCA ++ + + WVP+Y+G+ +D+CKL C+
Sbjct: 565 RFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQ 624
Query: 692 VAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSS 751
YY L RV+DGTPC D++ +CVQG C AGCD ++ SK + DKC VCGGD S
Sbjct: 625 AQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSG 684
Query: 752 CKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNF 811
C +G+F YGYN VV IPAGAT+I VRQ G YLAL G + LNG +
Sbjct: 685 CSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHR--SIYLALKLPDGSYALNGEY 742
Query: 812 VVTMAKREIRIGNAV-VEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNI 870
+ + ++ + AV + YSG+ A E ++ + Q L LQVL G + +RYSF +
Sbjct: 743 TLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFV 802
Query: 871 P 871
P
Sbjct: 803 P 803
Score = 40.4 bits (93), Expect = 0.017
Identities = 50/195 (25%), Positives = 73/195 (37%), Gaps = 44/195 (22%)
Query: 1191 WTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSC 1250
W+PCSA R+++ +NG L +P A VT G+ D C
Sbjct: 404 WSPCSA--------RFITDFLDNGY-----GHCLLDKPEAPLHLPVTFPGKDYDAD-RQC 449
Query: 1251 SVTCG-QGRATRQV----MCVNYSDHVIDRSECDQDYIPETDQDCSMSPC-PQRTPDSGL 1304
+T G R Q+ + S H+ + C + P D +PC P + G
Sbjct: 450 QLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADG----TPCGPAQACMGGR 505
Query: 1305 AQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTAN 1364
H Q +D+ A G W GPWG CS TC GG Q +++
Sbjct: 506 CLHMDQLQDFNIPQAG-------GWGPW--GPWGDCSRTCGGGVQ-----------FSSR 545
Query: 1365 DCVERIKPDEQRACE 1379
DC + + + CE
Sbjct: 546 DCTRPVPRNGGKYCE 560
Score = 37.0 bits (84), Expect = 0.19
Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 9/60 (15%)
Query: 1388 YGNWGECTKLCGGGIRTRLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACPHDAA 1444
+G WG+C++ CGGG++ C R NG ++ CE + CNT CP +A
Sbjct: 526 WGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKY----CE--GRRTRFRSCNTEDCPTGSA 579
Score = 35.0 bits (79), Expect = 0.71
Identities = 15/36 (41%), Positives = 18/36 (50%), Gaps = 1/36 (2%)
Query: 1100 MQTCQQPECASWQA-GPWGQCSVTCGQGYQLRAVKC 1134
+Q P+ W GPWG CS TCG G Q + C
Sbjct: 512 LQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDC 547
Score = 34.7 bits (78), Expect = 0.93
Identities = 36/150 (24%), Positives = 54/150 (36%), Gaps = 38/150 (25%)
Query: 976 DDGFCSSHPKPSNREKCSGECNTGGW---RYSAW---TEC--SKSCDGGTQRRRAICVNT 1027
D C P P CSG N ++S W T C +++C GG
Sbjct: 456 DSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGG----------- 504
Query: 1028 RNDVLDDSKCTHQEKVTIQRCSEFPCPQ---WKS-GDWSECLVTCGKGHKHRQVWCQFGE 1083
+C H +++ +F PQ W G W +C TCG G + C
Sbjct: 505 --------RCLHMDQL-----QDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPV 551
Query: 1084 DRLNDRMCDPETKPTSMQTCQQPECASWQA 1113
R + C E + T ++C +C + A
Sbjct: 552 PRNGGKYC--EGRRTRFRSCNTEDCPTGSA 579
Score = 33.9 bits (76), Expect = 1.6
Identities = 67/290 (23%), Positives = 91/290 (31%), Gaps = 77/290 (26%)
Query: 1419 DLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLES 1478
D C+ L PD C P A W CS GH + C K +
Sbjct: 446 DRQCQ-LTFGPDSRHCPQLPPPCAALW-------CS-----GHLNGHAMCQTKHSPWADG 492
Query: 1479 DYCKHLAKPHGHRKCRGGRC-----------PK---WKA-GAWSQCSVSCGRGVQ----- 1518
C + C GGRC P+ W G W CS +CG GVQ
Sbjct: 493 TPCGPA------QACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRD 546
Query: 1519 -----QRHVG-----------------CQIGTHKIARETECNPYT-RPESERDCQGPR-- 1553
R+ G C G+ RE +C Y R + + GP
Sbjct: 547 CTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDW 606
Query: 1554 CPLYTWRAEEWQECTKTC-GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRES-CSLQP 1611
P YT A + +C TC + Y V+ V G C V + C
Sbjct: 607 VPRYTGVAPQ-DQCKLTCQAQALGYYYVL----EPRVVDGTPCSPDSSSVCVQGRCIHAG 661
Query: 1612 CE-YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP 1660
C+ + ++ +C V G G CS+ + Y Y + P
Sbjct: 662 CDRIIGSKKKFDKCMVCGGDG-----SGCSKQSGSFRKFRYGYNNVVTIP 706
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 551 bits (1419), Expect = e-156
Identities = 310/795 (38%), Positives = 420/795 (52%), Gaps = 60/795 (7%)
Query: 149 HCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQ----NKPH 204
HCFY+G V+ + AV LC G+ G F Y ++PL E+E+ +
Sbjct: 129 HCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSAR 188
Query: 205 I--IYRRSAPQREPSTGRHACDTS-------EHKNRHSKDKKKTRARKWGERINLAGDVA 255
I +Y R E R +C+T EH HS N +G A
Sbjct: 189 ILHVYTREGFSFEALPPRASCETPASTPEAHEHAPAHS---------------NPSGRAA 233
Query: 256 ALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQH 315
+ L A S G T RR +R +S R VE+L+VAD M +G LQH
Sbjct: 234 LASQLLDQSALSPAGGSGPQT----WWRRRRRSISRARQVELLLVADASMARLYGRGLQH 289
Query: 316 YILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKN 375
Y+LTL SI +Y SI N I + +V ++V+ ++ +S NA TTLKNFC+WQH N
Sbjct: 290 YLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHN 349
Query: 376 SPGGIH---HDTAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTI 432
G H +D A+L TR+D+C H CDTLG+A++GTIC P RSC++ ED GL AFT+
Sbjct: 350 QLGDDHEEHYDAAILFTREDLC-GHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTV 408
Query: 433 AHELGHVFNMPHDDNNKCKEE-GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGY 491
AHE+GH+ + HDD+ C+E G + +M+ L WSKC+ ITEFLD G+
Sbjct: 409 AHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGH 468
Query: 492 GECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHK 551
G CLL+ P + P +LPG Y+ +QC L FGP VCP M C RLWC V
Sbjct: 469 GNCLLDLPRKQILG-PEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQM 527
Query: 552 GCRTQHTPWADGTECEPGKHCKYGFCVPKEMDV---PVTDGSWGSWSPFGTCSRTCGGGI 608
C T+ P +GT C G+ C G CV K + G+WGSW +G CSR+CGGG+
Sbjct: 528 VCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGV 587
Query: 609 KTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLL 668
+ A R CN P P+N G+YC G+R ++SC+ PC + FR EQC +G + G+
Sbjct: 588 QFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQSDAKGVK 647
Query: 669 PNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAG 728
V WVPKY+G+L D CKL CR G Y +V DGT C +N +CV+G C + G
Sbjct: 648 TFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRGKCVRTG 707
Query: 729 CDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSG 788
CD ++ SK + DKCGVCGGDNSSC + GTFN GY VVRIP GAT+I VRQ
Sbjct: 708 CDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKD 767
Query: 789 ETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINST--DRIE 846
+T YLAL GE+L+NG ++++ ++ I I V+ YSG + ++ +
Sbjct: 768 QTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATK 827
Query: 847 QELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSH----------------GPWQAC 890
+ L++Q+L+ DVRYSF +P + P+ SH GPW AC
Sbjct: 828 EILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLAC 887
Query: 891 SKPCQ-GERKRKLVC 904
S+ C G R + C
Sbjct: 888 SRTCDTGWHTRTVQC 902
Score = 50.4 bits (119), Expect = 2e-05
Identities = 87/371 (23%), Positives = 128/371 (34%), Gaps = 53/371 (14%)
Query: 1056 WKS-GDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECA-SWQA 1113
W S G W +C +CG G + C R N R C K ++C C + ++
Sbjct: 570 WGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG--KRAIYRSCSLMPCPPNGKS 627
Query: 1114 GPWGQCSVTCGQGYQLRAVKCIIG---TYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
QC G + VK + Y V+ + C R T + S P
Sbjct: 628 FRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFS---PKV 684
Query: 1171 APETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVA 1230
T YS T C G ++++Y C G D S+C +
Sbjct: 685 TDGTECRLYSNSVCVRGKCVRTGCDGIIG--SKLQYDKCGVCGG---DNSSCTKIVGTFN 739
Query: 1231 KEECSVT-----PCG-------QWKALDWSSCSVTCGQGRATRQVMC-----VNYSDHVI 1273
K+ T P G Q+KA D + + + + + ++ S+ +I
Sbjct: 740 KKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETII 799
Query: 1274 DRSECDQDYIPETDQD-----CSMSPCPQRTPDSGLAQHPFQNEDYR-----PRSASPSR 1323
D + +Y + +D S + LA P + D R P+ ++P
Sbjct: 800 DINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKV 859
Query: 1324 THVL--GGN---------QWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKP 1372
V G N QW TGPW ACS TC G R V CQD N A C +P
Sbjct: 860 NSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRP 919
Query: 1373 DEQRACESGPC 1383
+ C C
Sbjct: 920 SAFKQCLLKKC 930
Score = 41.6 bits (96), Expect = 0.008
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 2/56 (3%)
Query: 1499 PKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRC 1554
P+W G W CS +C G R V CQ G K+A+ C RP + + C +C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAK--GCPLSQRPSAFKQCLLKKC 930
Score = 40.8 bits (94), Expect = 0.013
Identities = 20/56 (35%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 1384 PQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
PQW G W C++ C G TR V CQ +G R C + +P +QC C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQ--DGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 40.4 bits (93), Expect = 0.017
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 1054 PQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
PQW +G W C TC G R V CQ G +L + C +P++ + C +C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKL-AKGCPLSQRPSAFKQCLLKKC 930
Score = 40.4 bits (93), Expect = 0.017
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 2/54 (3%)
Query: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W W C++TC G R V C D N+ G C +S+RP + C L+ C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG--CPLSQRPSAFKQCLLKKC 930
Score = 39.7 bits (91), Expect = 0.029
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 16/83 (19%)
Query: 1366 CVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQ----RSN-----GER 1416
CV++ K G W G+WG+C++ CGGG++ C R+N G+R
Sbjct: 553 CVDKTKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKR 610
Query: 1417 FPDLSCEILDKPPD-----REQC 1434
SC ++ PP+ EQC
Sbjct: 611 AIYRSCSLMPCPPNGKSFRHEQC 633
Score = 39.7 bits (91), Expect = 0.029
Identities = 18/54 (33%), Positives = 27/54 (50%), Gaps = 2/54 (3%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
W TGPW +CS +C G R V C +DG+ + C +P ++C +C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 38.1 bits (87), Expect = 0.084
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 10/61 (16%)
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSV-HPCYLRD 1674
W+TG W CS TC G+ R V C + + + CP +Q PS C L+
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQ---------DGNRKLAKGCPLSQRPSAFKQCLLKK 929
Query: 1675 C 1675
C
Sbjct: 930 C 930
Score = 37.7 bits (86), Expect = 0.11
Identities = 47/188 (25%), Positives = 58/188 (30%), Gaps = 50/188 (26%)
Query: 1091 CDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNA 1150
C +TK T SW G WGQCS +CG G Q
Sbjct: 553 CVDKTKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFA-------------------- 590
Query: 1151 ATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210
+ C P AP + R +R S PC G R+ C
Sbjct: 591 ------YRHCNNP-------APRNNGRYCTGKRAIYRSCSLMPCPP---NGKSFRHEQCE 634
Query: 1211 DENGSVADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSD 1270
+NG +D T V K V P C +TC RA V +S
Sbjct: 635 AKNGYQSDAKGVKTFVEWVPK-YAGVLPA--------DVCKLTC---RAKGTGYYVVFSP 682
Query: 1271 HVIDRSEC 1278
V D +EC
Sbjct: 683 KVTDGTEC 690
Score = 36.2 bits (82), Expect = 0.32
Identities = 23/64 (35%), Positives = 30/64 (46%), Gaps = 8/64 (12%)
Query: 993 SGECNTGGWRYSAWTECSKSCDGGTQRRRAICVN--TRNDVLDDSKCTHQEKVTIQRCSE 1050
S N G W +W +CS+SC GG Q C N RN + CT + + + CS
Sbjct: 565 SSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRN---NGRYCTGKRAI-YRSCSL 618
Query: 1051 FPCP 1054
PCP
Sbjct: 619 MPCP 622
Score = 34.7 bits (78), Expect = 0.93
Identities = 22/77 (28%), Positives = 34/77 (44%), Gaps = 5/77 (6%)
Query: 1165 CHPPPAAPETRRSTYS-APRTQW-RFGSWTPCSATCGKGTRMRYVSCRDENGSVADESAC 1222
C +T++ YS + W +GSW CS +CG G + Y C N + +
Sbjct: 548 CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHC--NNPAPRNNGRY 605
Query: 1223 ATLPRPVAKEECSVTPC 1239
T R + + CS+ PC
Sbjct: 606 CTGKRAIYR-SCSLMPC 621
Score = 33.1 bits (74), Expect = 2.7
Identities = 15/47 (31%), Positives = 21/47 (44%)
Query: 1681 WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
W G W +CS +C G R+VQC + + C +P K C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQC 925
Score = 32.3 bits (72), Expect = 4.6
Identities = 17/49 (34%), Positives = 26/49 (53%), Gaps = 3/49 (6%)
Query: 1564 WQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W +C+++CG G ++ C +N + R KR + R SCSL PC
Sbjct: 576 WGQCSRSCGGGVQFAYRHC--NNPAPRNNGRYCTGKRAIYR-SCSLMPC 621
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 550 bits (1418), Expect = e-156
Identities = 355/1050 (33%), Positives = 517/1050 (49%), Gaps = 107/1050 (10%)
Query: 36 PRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTS 95
P + E + +IV P+RV+A G + + R+ S PAF
Sbjct: 31 PAPGRATEGRAALDIVHPVRVDAGGSFLSYELWPRALRKRDVSVRRDAPAF--------- 81
Query: 96 SQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGY 155
Y L G++ FNLTAN +AP F G+ + + A C G
Sbjct: 82 ----YELQYRGRELRFNLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPA----CHLLGE 133
Query: 156 VNTNSEH--TAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAP- 212
V A IS C G+ G F+ + DYFIEPL S + + PH++Y+R AP
Sbjct: 134 VQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPARPGHAQ---PHVVYKRQAPE 190
Query: 213 ---QREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAY 269
QR S+ C + S+ ++ + ++W
Sbjct: 191 RLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQW------------------------- 225
Query: 270 GNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGE-NLQHYILTLMSIVASIY 328
R R R +R +S ++VE LVVAD +MV YHG+ ++ Y+LT+M++VA ++
Sbjct: 226 -------RRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIMNMVAGLF 278
Query: 329 KDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGG---IHHDTA 385
DPSIGN I+I IV L+++ +E++ I+ +A TLK+FC+WQ S N G +HHDTA
Sbjct: 279 HDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQKSINMKGDAHPLHHDTA 338
Query: 386 VLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPH 444
+LLTR+D+C A ++ C+TLGL+ + +C P+RSCSI+ED+GL AFT+AHELGH F + H
Sbjct: 339 ILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHELGHSFGIQH 398
Query: 445 DDN-NKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRP 503
D + N C+ G K P +M+P L + P WS+CSR+YIT FLD G+G CL + P
Sbjct: 399 DGSGNDCEPVG-KRP-FIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDDPPAKDI 456
Query: 504 YPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWAD 562
P PG+LY+V+ QC L +G S C M C LWC+ V C ++ D
Sbjct: 457 IDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCS----VGTTCHSKLDAAVD 512
Query: 563 GTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKN 622
GT C K C G CVP DG W WS + CSR+CG G+++A R+C +P PK
Sbjct: 513 GTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMGVQSAERQCTQPTPKY 572
Query: 623 GGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILM 682
G+YCVG R +F+ CN + C + FR QC+HFD + G L WVP + +
Sbjct: 573 KGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLY--KGQLHT--WVPVVNDV-- 626
Query: 683 KDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQ--DTNDICVQGLCRQAGCDHVLNSKARRD 740
+ C+L CR A +LRD V+DGTPC Q + D+C+ G+C+ GCD ++S A D
Sbjct: 627 -NPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEIDSGAMED 685
Query: 741 KCGVCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALS 799
+CGVC G+ S+C TV+GTF GY V IPAGA I +++ + N+LAL
Sbjct: 686 RCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQE-----VAEAANFLALR 740
Query: 800 SSKGE-FLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGK 858
S E + LNG + + + ++ Y+ E + S ++ + +Q+L +
Sbjct: 741 SEDPEKYFLNGGWTIQW-NGDYQVAGTTFTYA-RRGNWENLTSPGPTKEPVWIQLLF--Q 796
Query: 859 LYNPDVRYSFNIPIED------KPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLT 912
NP V Y + I E P F W+ +GPW C+ C +R+ V E
Sbjct: 797 ESNPGVHYEYTIHREAGGHDEVPPPVFSWH-YGPWTKCTVTCGRGVQRQNVYCLERQAGP 855
Query: 913 VSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGL-GYRTLDIYCAKYSRLDG 970
V ++ CD L +P C C RW CS+ CG G + C + LD
Sbjct: 856 VDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLD- 914
Query: 971 KTEKVDDGFCSSHPKPSNREKCSGECN-TGGWRYSAWTECSKSCDGGTQRRRAICVNTRN 1029
+ ++ C P+P C+ W W++CS +C GTQRR +C N
Sbjct: 915 EQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG 974
Query: 1030 DVLDDSKCTHQEKVTIQRCSEFPCPQWKSG 1059
D++ Q+ + CS P +W G
Sbjct: 975 VPCDEA----QQPASEVTCS-LPLCRWPLG 999
Score = 141 bits (356), Expect = 5e-33
Identities = 81/247 (32%), Positives = 102/247 (41%), Gaps = 30/247 (12%)
Query: 1056 WKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGP 1115
W++G+WSEC TCG G R V C G D C P +P + C CA+W +G
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDE----DCAPAGRPQPARRCHLRPCATWHSGN 1470
Query: 1116 WGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETR 1175
W +CS +CG G +R V+C VD D RP C P PA P
Sbjct: 1471 WSKCSRSCGGGSSVRDVQC--------VDTRDLRPL-RPFH--------CQPGPAKPPAH 1513
Query: 1176 RSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECS 1235
R + P W SW CS CG G + R V+C + C RP C+
Sbjct: 1514 RPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTC-------PEPGLCEEALRPNTTRPCN 1566
Query: 1236 VTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHV--IDRSECDQDYIPETDQDCSMS 1293
PC QW W CS CG G R V CVN + D +C + PE+ + C
Sbjct: 1567 THPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTE 1626
Query: 1294 PCPQRTP 1300
C P
Sbjct: 1627 DCEPVEP 1633
Score = 140 bits (354), Expect = 9e-33
Identities = 83/240 (34%), Positives = 111/240 (46%), Gaps = 31/240 (12%)
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWR 1560
W+AG WS+CS +CG G R V C G R+ +C P RP+ R C C TW
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSG-----RDEDCAPAGRPQPARRCHLRPCA--TWH 1467
Query: 1561 AEEWQECTKTCGEGSRYRKVVCVDDNK-NEVHGARCDVSK-RPVDRESCSLQPCEYVWIT 1618
+ W +C+++CG GS R V CVD + C +P C QPC W T
Sbjct: 1468 SGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-LSWYT 1526
Query: 1619 GEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVS 1678
W ECS CG G +QRLV+C E +E + T+P + HPC
Sbjct: 1527 SSWRECSEACGGGEQQRLVTCPEPGLCEE--------ALRPNTTRPCNTHPC-------- 1570
Query: 1679 ATWRVGNWGSCSVSCGVGVMQRSVQCLTNE----DQPSHLCHTDLKPEERKTCRNVYNCE 1734
W VG WG CS CG GV +R V+C+ + ++ S C + PE + C +CE
Sbjct: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC-GTEDCE 1629
Score = 139 bits (350), Expect = 3e-32
Identities = 88/275 (32%), Positives = 114/275 (41%), Gaps = 52/275 (18%)
Query: 1168 PPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPR 1227
PPA P R+ W+ G+W+ CS TCG G R V C S + CA R
Sbjct: 1403 PPADPLVVRNA------GWQAGNWSECSTTCGLGAVWRPVRC-----SSGRDEDCAPAGR 1451
Query: 1228 PVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETD 1287
P C + PC W + +WS CS +CG G + R V CV+ +D P
Sbjct: 1452 PQPARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVD-----------TRDLRPLRP 1500
Query: 1288 QDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGG 1347
C P P + P +RP A P + W T W CS C GG
Sbjct: 1501 FHCQ--PGPAKPPA------------HRPCGAQPCLS-------WYTSSWRECSEACGGG 1539
Query: 1348 SQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLV 1407
Q+R+V C + C E ++P+ R C + PC QW G WG+C+ CGGG++ RLV
Sbjct: 1540 EQQRLVTCPEPGL-----CEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLV 1594
Query: 1408 VC---QRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
C Q E D C P C T C
Sbjct: 1595 KCVNTQTGLPEEDSD-QCGHEAWPESSRPCGTEDC 1628
Score = 134 bits (338), Expect = 7e-31
Identities = 79/238 (33%), Positives = 100/238 (42%), Gaps = 17/238 (7%)
Query: 1321 PSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACES 1380
P+ V+ W+ G W CS+TC G+ R V C DC +P R C
Sbjct: 1404 PADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRD---EDCAPAGRPQPARRCHL 1460
Query: 1381 GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILD-KPPDREQCNTHA 1438
PC W GNW +C++ CGGG R V C + R C+ KPP C
Sbjct: 1461 RPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQP 1520
Query: 1439 CPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
C +W T W CS +CG G +QR V C E C+ +P+ R C C
Sbjct: 1521 C---LSWYTSSWRECSEACGGGEQQRLVTCP-------EPGLCEEALRPNTTRPCNTHPC 1570
Query: 1499 PKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARE--TECNPYTRPESERDCQGPRC 1554
+W G W QCS CG GVQ+R V C + E +C PES R C C
Sbjct: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 127 bits (320), Expect = 8e-29
Identities = 83/281 (29%), Positives = 101/281 (35%), Gaps = 71/281 (25%)
Query: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
A WQAG W +CS TCG G R V+C G D DC A RP + C L C
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGR------DEDCAPAGRPQPARRCHLRPC--- 1463
Query: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENG-SVADESACATLP- 1226
W G+W+ CS +CG G+ +R V C D C P
Sbjct: 1464 ---------------ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPA 1508
Query: 1227 RPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPET 1286
+P A C PC W W CS CG G R V C + C++ P T
Sbjct: 1509 KPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCP-------EPGLCEEALRPNT 1561
Query: 1287 DQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAG 1346
+ C+ PC QW GPWG CS C G
Sbjct: 1562 TRPCNTHPC----------------------------------TQWVVGPWGQCSGPCGG 1587
Query: 1347 GSQRRVVVC-QDENGYTAND---CVERIKPDEQRACESGPC 1383
G QRR+V C + G D C P+ R C + C
Sbjct: 1588 GVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 124 bits (312), Expect = 7e-28
Identities = 63/179 (35%), Positives = 94/179 (52%), Gaps = 14/179 (7%)
Query: 1444 AWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHG-HRKCRGGRCP-KW 1501
+W GPW+ C+V+CGRG +++NVYC+ + ++ ++C L +P RKC CP +W
Sbjct: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
Query: 1502 KAGAWSQCSVSCG-RGVQQRHVGC----QIGTHKIARETECNPYTRPESERDC-QGPRCP 1555
AG W CS SCG G+ +R V C + C RP +E C + CP
Sbjct: 884 WAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCP 943
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEY 1614
TW W +C+ TCGEG++ R V+C +D G CD +++P +CSL C +
Sbjct: 944 A-TWAVGNWSQCSVTCGEGTQRRNVLCTNDT-----GVPCDEAQQPASEVTCSLPLCRW 996
Score = 124 bits (311), Expect = 9e-28
Identities = 78/248 (31%), Positives = 105/248 (42%), Gaps = 29/248 (11%)
Query: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCS-GECN 997
W + SECS CGLG + C+ G+ E C+ +P +C C
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSS-----GRDED-----CAPAGRPQPARRCHLRPCA 1464
Query: 998 TGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQE----KVTIQR-CSEFP 1052
T W W++CS+SC GG+ R CV+TR+ L + H + K R C P
Sbjct: 1465 T--WHSGNWSKCSRSCGGGSSVRDVQCVDTRD--LRPLRPFHCQPGPAKPPAHRPCGAQP 1520
Query: 1053 CPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQ 1112
C W + W EC CG G + R V C +C+ +P + + C C W
Sbjct: 1521 CLSWYTSSWRECSEACGGGEQQRLVTCP------EPGLCEEALRPNTTRPCNTHPCTQWV 1574
Query: 1113 AGPWGQCSVTCGQGYQLRAVKCI-IGTYMSVVDDNDCNAATRPTDTQDCELPSCHP--PP 1169
GPWGQCS CG G Q R VKC+ T + D + C P ++ C C P PP
Sbjct: 1575 VGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDCEPVEPP 1634
Query: 1170 AAPETRRS 1177
R S
Sbjct: 1635 RCERDRLS 1642
Score = 116 bits (290), Expect = 2e-25
Identities = 73/245 (29%), Positives = 93/245 (37%), Gaps = 35/245 (14%)
Query: 1000 GWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQWKSG 1059
GW+ W+ECS +C G R C + R D+ +RC PC W SG
Sbjct: 1414 GWQAGNWSECSTTCGLGAVWRPVRCSSGR----DEDCAPAGRPQPARRCHLRPCATWHSG 1469
Query: 1060 DWSECLVTCGKGHKHRQVWCQFGED--RLNDRMCDP-ETKPTSMQTCQQPECASWQAGPW 1116
+WS+C +CG G R V C D L C P KP + + C C SW W
Sbjct: 1470 NWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSW 1529
Query: 1117 GQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRR 1176
+CS CG G Q R V C + C A RP T+ C C
Sbjct: 1530 RECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNTHPC----------- 1570
Query: 1177 STYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESA--CATLPRPVAKEEC 1234
TQW G W CS CG G + R V C + + +E + C P + C
Sbjct: 1571 -------TQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC 1623
Query: 1235 SVTPC 1239
C
Sbjct: 1624 GTEDC 1628
Score = 115 bits (287), Expect = 5e-25
Identities = 63/175 (36%), Positives = 83/175 (47%), Gaps = 8/175 (4%)
Query: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRE-SCSLQPCE 1613
P+++W W +CT TCG G + + V C++ V CD RP D++ CS QPC
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 1614 YVWITGEWSECSVTCGKG-YKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
W GEW CS +CG G +R V C E + P +PP+ PC
Sbjct: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLP--RPPTETPCN- 937
Query: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
R P ATW VGNW CSV+CG G +R+V C + P C +P TC
Sbjct: 938 RHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP---CDEAQQPASEVTC 989
Score = 113 bits (282), Expect = 2e-24
Identities = 67/181 (37%), Positives = 87/181 (48%), Gaps = 15/181 (8%)
Query: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDRE-QCNTHACP 1440
P W YG W +CT CG G++ + V C + C+ L +P D++ +C+ CP
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 1441 HDAAWSTGPWSSCSVSCGRGH-KQRNVYCMAKDG----SHLESDYCKHLAKPHGHRKC-R 1494
A W G W CS SCG G +R V C+ G S LE C+HL +P C R
Sbjct: 881 --ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNR 938
Query: 1495 GGRCP-KWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPR 1553
CP W G WSQCSV+CG G Q+R+V C T C+ +P SE C P
Sbjct: 939 HVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDT-----GVPCDEAQQPASEVTCSLPL 993
Query: 1554 C 1554
C
Sbjct: 994 C 994
Score = 112 bits (280), Expect = 4e-24
Identities = 66/182 (36%), Positives = 85/182 (46%), Gaps = 16/182 (8%)
Query: 1332 WRTGPWGACSSTCAGGSQRRVVVCQDENGYTAND--CVERIKPDEQ-RACESGPCP-QWA 1387
W GPW C+ TC G QR+ V C + ++ C +PD+Q R C PCP +W
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
Query: 1388 YGNWGECTKLCG-GGIRTRLVVCQRSNG----ERFPDLSCEILDKPPDREQCNTHACPHD 1442
G W C+ CG GG+ R V+C RS G +CE L +PP CN H P
Sbjct: 885 AGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHV-PCP 943
Query: 1443 AAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWK 1502
A W+ G WS CSV+CG G ++RNV C G C +P C C +W
Sbjct: 944 ATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP-----CDEAQQPASEVTCSLPLC-RWP 997
Query: 1503 AG 1504
G
Sbjct: 998 LG 999
Score = 107 bits (266), Expect = 1e-22
Identities = 75/231 (32%), Positives = 101/231 (43%), Gaps = 37/231 (16%)
Query: 1106 PECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
P SW GPW +C+VTCG+G Q + V C + VD+ C+ RP D Q
Sbjct: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYC-LERQAGPVDEEHCDPLGRPDDQQ------- 871
Query: 1166 HPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRDENG----SVADES 1220
R+ + +W G W CS++CG G R V C G S +
Sbjct: 872 ---------RKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPP 922
Query: 1221 ACATLPRPVAKEECS-VTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSEC 1278
AC LPRP + C+ PC W +WS CSVTCG+G R V+C N + C
Sbjct: 923 ACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG-----VPC 977
Query: 1279 DQDYIPETDQDCSMSPC--PQRT-----PDSGLAQHPFQNE-DYRPRSASP 1321
D+ P ++ CS+ C P T SG + H NE D+ P +P
Sbjct: 978 DEAQQPASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHHLAP 1028
Score = 102 bits (254), Expect = 4e-21
Identities = 64/214 (29%), Positives = 92/214 (42%), Gaps = 35/214 (16%)
Query: 1182 PRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKE-ECSVTPC- 1239
P W +G WT C+ TCG+G + + V C + DE C L RP ++ +CS PC
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 1240 GQWKALDWSSCSVTCGQGRATRQ-VMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQR 1298
+W A +W CS +CG G +R+ V+C+ + +Q P +
Sbjct: 881 ARWWAGEWQLCSSSCGPGGLSRRAVLCIRS--------------VGLDEQSALEPPACEH 926
Query: 1299 TPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDE 1358
P RP + +P HV W G W CS TC G+QRR V+C ++
Sbjct: 927 LP--------------RPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTND 972
Query: 1359 NGYTANDCVERIKPDEQRACESGPCPQWAYGNWG 1392
G C E +P + C S P +W G G
Sbjct: 973 TGV---PCDEAQQPASEVTC-SLPLCRWPLGTLG 1002
Score = 101 bits (251), Expect = 8e-21
Identities = 65/195 (33%), Positives = 93/195 (47%), Gaps = 28/195 (14%)
Query: 1052 PCPQWKSGDWSECLVTCGKGHKHRQVWC---QFGEDRLNDRMCDPETKPTSMQT-CQQPE 1107
P W G W++C VTCG+G + + V+C Q G +++ CDP +P Q C +
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGP--VDEEHCDPLGRPDDQQRKCSEQP 878
Query: 1108 C-ASWQAGPWGQCSVTCGQG-YQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
C A W AG W CS +CG G RAV CI + D +A P P+C
Sbjct: 879 CPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGL------DEQSALEP--------PAC 924
Query: 1166 HPPPAAP-ETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACAT 1224
P P ET + + W G+W+ CS TCG+GT+ R V C ++ G DE+
Sbjct: 925 EHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEA---- 980
Query: 1225 LPRPVAKEECSVTPC 1239
+P ++ CS+ C
Sbjct: 981 -QQPASEVTCSLPLC 994
Score = 91.7 bits (226), Expect = 6e-18
Identities = 58/212 (27%), Positives = 80/212 (37%), Gaps = 48/212 (22%)
Query: 1238 PCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQ-DCSMSPCP 1296
P W W+ C+VTCG+G + V C+ +D CD P+ Q CS PCP
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCA-GGSQRRVVVC 1355
R W G W CSS+C GG RR V+C
Sbjct: 881 AR---------------------------------WWAGEWQLCSSSCGPGGLSRRAVLC 907
Query: 1356 ------QDENGYTANDCVERIKPDEQRACESG-PCP-QWAYGNWGECTKLCGGGIRTRLV 1407
+++ C +P + C PCP WA GNW +C+ CG G + R V
Sbjct: 908 IRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNV 967
Query: 1408 VCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
+C G + C+ +P C+ C
Sbjct: 968 LCTNDTG-----VPCDEAQQPASEVTCSLPLC 994
Score = 74.7 bits (182), Expect = 8e-13
Identities = 48/163 (29%), Positives = 65/163 (39%), Gaps = 17/163 (10%)
Query: 881 WNSHGPWQACSKPCQGERK-RKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRW 939
W+S G W CS+ C G R + C D + C P PCG L W
Sbjct: 1466 WHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSW 1524
Query: 940 HVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTG 999
+ +S ECS CG G + + C + G C +P+ C+ T
Sbjct: 1525 YTSSWRECSEACGGGEQQRLVTCP------------EPGLCEEALRPNTTRPCNTHPCT- 1571
Query: 1000 GWRYSAWTECSKSCDGGTQRRRAICVNTRNDV--LDDSKCTHQ 1040
W W +CS C GG QRR CVNT+ + D +C H+
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHE 1614
Score = 57.4 bits (137), Expect = 1e-07
Identities = 32/96 (33%), Positives = 48/96 (50%), Gaps = 8/96 (8%)
Query: 1611 PCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
P + W G W++C+VTCG+G +++ V C E G + E+ + G C
Sbjct: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEH-----CDPLGRPDDQQRKC 874
Query: 1671 YLRDCPVSATWRVGNWGSCSVSCGV-GVMQRSVQCL 1705
+ CP A W G W CS SCG G+ +R+V C+
Sbjct: 875 SEQPCP--ARWWAGEWQLCSSSCGPGGLSRRAVLCI 908
Score = 45.8 bits (107), Expect = 4e-04
Identities = 25/75 (33%), Positives = 34/75 (45%), Gaps = 22/75 (29%)
Query: 1660 PGTQP---------PSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNED- 1709
P TQP P P +R+ A W+ GNW CS +CG+G + R V+C + D
Sbjct: 1389 PETQPLAPSLAEAGPPADPLVVRN----AGWQAGNWSECSTTCGLGAVWRPVRCSSGRDE 1444
Query: 1710 --------QPSHLCH 1716
QP+ CH
Sbjct: 1445 DCAPAGRPQPARRCH 1459
Score = 38.9 bits (89), Expect = 0.049
Identities = 21/71 (29%), Positives = 30/71 (42%), Gaps = 11/71 (15%)
Query: 1648 NYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN 1707
+YEY+ PP V +W G W C+V+CG GV +++V CL
Sbjct: 803 HYEYTIHREAGGHDEVPPPVF-----------SWHYGPWTKCTVTCGRGVQRQNVYCLER 851
Query: 1708 EDQPSHLCHTD 1718
+ P H D
Sbjct: 852 QAGPVDEEHCD 862
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 546 bits (1406), Expect = e-154
Identities = 351/1036 (33%), Positives = 523/1036 (50%), Gaps = 104/1036 (10%)
Query: 37 RQVKLLETLSEYEIVSPIRVNALGEPFPTNVHF----KRTRRSINSATDPWPAFASSSSS 92
RQ ++ L EY +V P+RV+A G +H+ R +R ++ + D W
Sbjct: 41 RQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSED-W--------- 90
Query: 93 STSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFY 152
+YR+S + FNLT N GF++ + + ++ K + A L H
Sbjct: 91 -----VYYRISHEEKDLFFNLTVNQGFLSNSYIMEKR-YGNLSHVKMMASS-APLCHLSG 143
Query: 153 KGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAP 212
TA +S C G+ G F+ GD+FIEP++ E PHI+YRR
Sbjct: 144 TVLQQGTRVGTAALSACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYH---PHIVYRR--- 197
Query: 213 QREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNK 272
Q+ P T C + N K++ KW ER NL
Sbjct: 198 QKVPETKEPTCGLKDSVN--ISQKQELWREKW-ERHNLP--------------------- 233
Query: 273 TDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDP 331
+ ++R +S R+VE LVVAD +M+ YHG EN++ YILT+M++V ++ +P
Sbjct: 234 --------SRSLSRRSISKERWVETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNP 285
Query: 332 SIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHS---KNSPGGIHHDTAVLL 388
SIGN I+IV+V LI++ E+ G I +A+ TL +FC+WQ S K+ +HHD AVLL
Sbjct: 286 SIGNAIHIVVVRLILLEEEEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLL 345
Query: 389 TRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDN 447
TR+DIC ++ C+TLGL+ L +C P+RSC+I+EDSGL AFTIAHELGH F + HD
Sbjct: 346 TRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGK 405
Query: 448 -NKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPL 506
N C+ G + P ++M+ L + P WSKCS +YIT FLD G+G CL + P+ +
Sbjct: 406 ENDCEPVG-RHP-YIMSRQLQYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKS 463
Query: 507 PVQLPGILYNVNKQCELIFGPGSQVCPYMMQ-CRRLWCNNVNGVHKGCRTQHTPWADGTE 565
V PG++Y+V+ QC+L +GP + C + C+ LWC+ V CR++ ADGT+
Sbjct: 464 KVIAPGVIYDVHHQCQLQYGPNATFCQEVENVCQTLWCS----VKGFCRSKLDAAADGTQ 519
Query: 566 CEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGK 625
C K C G C+ G WG WSP+ CSRTCG G+++A R CN PEPK GGK
Sbjct: 520 CGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGK 579
Query: 626 YCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDR 685
YC G R +++ CN PC + FR QC+ FD + N L W P ++
Sbjct: 580 YCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDTVPYK-NEL---YHWFPIFN---PAHP 632
Query: 686 CKLFCRVAGNTAYYQLRDRVIDGTPC--GQDTNDICVQGLCRQAGCDHVLNSKARRDKCG 743
C+L+CR ++ D VIDGTPC G ++ ++C+ G+C+ GCD+ ++S A D+CG
Sbjct: 633 CELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCG 692
Query: 744 VCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSK 802
VC GD SSC+TV F GY + IP GA +I V + +G N+LA+ S
Sbjct: 693 VCLGDGSSCQTVRKMFKQKEGSGYVDIGLIPKGARDIRVMEIEGAG-----NFLAIRSED 747
Query: 803 GE-FLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYN 861
E + LNG F++ ++ V +Y + +E++ +T + + +Q+L ++ N
Sbjct: 748 PEKYYLNGGFIIQW-NGNYKLAGTVFQYD-RKGDLEKLMATGPTNESVWIQLLF--QVTN 803
Query: 862 PDVRYSFNIPIE----DKPQQFYWNSHGPWQACSKPC-QGERKRKLVCTRESDQLTVSDQ 916
P ++Y + I + D QQ Y+ +G W CS C G R++ C ++ + V
Sbjct: 804 PGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGM-VKAT 862
Query: 917 RCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEK 974
CD QP + C C RW CSA CG G + + C + D +
Sbjct: 863 FCDPETQPNGRQKKCHEKACPPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALP 922
Query: 975 VDDGFCSSHPKPSNREKCSGE-CNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLD 1033
D C KP C+ + W W+ECS SC GG + R C ++ D
Sbjct: 923 PTD--CQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCD 980
Query: 1034 DSKCTHQEKVT-IQRC 1048
++ + + +Q+C
Sbjct: 981 VTRKPNSRALCGLQQC 996
Score = 136 bits (342), Expect = 2e-31
Identities = 80/264 (30%), Positives = 103/264 (39%), Gaps = 51/264 (19%)
Query: 1186 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWKAL 1245
W G+W+ CS TCG G R V C S +S CA + RP + C + PC WK
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVEC-----STQMDSDCAAIQRPDPAKRCHLRPCAGWKVG 1371
Query: 1246 DWSSCSVTCGQGRATRQVMCVNYSDHVIDRS-ECD--QDYIPETDQDCSMSPCPQRTPDS 1302
+WS CS C G R++ CV+ DH R C P C+ PC
Sbjct: 1372 NWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC------- 1424
Query: 1303 GLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYT 1362
W+ PW CS +C GG Q R V C
Sbjct: 1425 ---------------------------EAWQVEPWSQCSRSCGGGVQERGVFC------P 1451
Query: 1363 ANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLS- 1421
C +P +C C WA GNW C+ CGGG + R V C S G + D
Sbjct: 1452 GGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQ 1511
Query: 1422 --CEILDKPPDREQCNTHACPHDA 1443
C+ +PP+ ++CN AC A
Sbjct: 1512 CLCDHKPRPPEFKKCNQQACKKSA 1535
Score = 133 bits (335), Expect = 1e-30
Identities = 74/233 (31%), Positives = 95/233 (40%), Gaps = 20/233 (8%)
Query: 1328 GGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWA 1387
G W G W CS+TC G+ R V C + +DC +PD + C PC W
Sbjct: 1313 GSAHWIVGNWSECSTTCGLGAYWRRVECSTQMD---SDCAAIQRPDPAKRCHLRPCAGWK 1369
Query: 1388 YGNWGECTKLCGGGIRTRLVVCQRSNGER-FPDLSCEILD--KPPDREQCNTHACPHDAA 1444
GNW +C++ C GG + R + C S R C+ L PP CN C A
Sbjct: 1370 VGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC---EA 1426
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAG 1504
W PWS CS SCG G ++R V+C C +P C C W G
Sbjct: 1427 WQVEPWSQCSRSCGGGVQERGVFC--------PGGLCDWTKRPTSTMSCNEHLCCHWATG 1478
Query: 1505 AWSQCSVSCGRGVQQRHVGCQIGTHKIARETE---CNPYTRPESERDCQGPRC 1554
W CS SCG G Q+R V C + + C+ RP + C C
Sbjct: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 131 bits (330), Expect = 6e-30
Identities = 77/234 (32%), Positives = 102/234 (43%), Gaps = 24/234 (10%)
Query: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAW 1445
W GNW EC+ CG G R V C D C + +P ++C+ C A W
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQM-----DSDCAAIQRPDPAKRCHLRPC---AGW 1368
Query: 1446 STGPWSSCSVSCGRGHKQRNVYCM-AKDGSHLESDYCKHLA--KPHGHRKCRGGRCPKWK 1502
G WS CS +C G K R + C+ ++D +L +C+ LA P C C W+
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQ 1428
Query: 1503 AGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAE 1562
WSQCS SCG GVQ+R V C G C+ RP S C C W
Sbjct: 1429 VEPWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLC--CHWATG 1478
Query: 1563 EWQECTKTCGEGSRYRKVVCVDDNKNEVHG---ARCDVSKRPVDRESCSLQPCE 1613
W C+ +CG G + R V CV N+ CD RP + + C+ Q C+
Sbjct: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK 1532
Score = 129 bits (324), Expect = 3e-29
Identities = 76/267 (28%), Positives = 104/267 (38%), Gaps = 58/267 (21%)
Query: 1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
W +WS CS TCG G R+V C D S+C P+ + C + PC
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMD-----SDCAAIQRPDPAKRCHLRPCAG---- 1367
Query: 1302 SGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVC---QDE 1358
W+ G W CS C+GG + R + C +D
Sbjct: 1368 ------------------------------WKVGNWSKCSRNCSGGFKIREIQCVDSRDH 1397
Query: 1359 NGYTANDC--VERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
C + I P +C PC W W +C++ CGGG++ R V C
Sbjct: 1398 RNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFC------- 1450
Query: 1417 FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHL 1476
P C+ +P CN H C H W+TG W CS SCG G ++R V C+ +G+
Sbjct: 1451 -PGGLCDWTKRPTSTMSCNEHLCCH---WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKT 1506
Query: 1477 ESD---YCKHLAKPHGHRKCRGGRCPK 1500
E C H +P +KC C K
Sbjct: 1507 EDQDQCLCDHKPRPPEFKKCNQQACKK 1533
Score = 125 bits (313), Expect = 5e-28
Identities = 91/334 (27%), Positives = 130/334 (38%), Gaps = 59/334 (17%)
Query: 972 TEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV 1031
T + +GF + SN ++ + + W W+ECS +C G RR C +
Sbjct: 1291 TSLITEGFLLN---ASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVEC----STQ 1343
Query: 1032 LDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMC 1091
+D Q +RC PC WK G+WS+C C G K R++ C D N R
Sbjct: 1344 MDSDCAAIQRPDPAKRCHLRPCAGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPF 1403
Query: 1092 DPE----TKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDND 1147
+ P +C C +WQ PW QCS +CG G Q R V C G
Sbjct: 1404 HCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL--------- 1454
Query: 1148 CNAATRPTDTQDC-ELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRY 1206
C+ RPT T C E CH W G+W CS +CG G + R
Sbjct: 1455 CDWTKRPTSTMSCNEHLCCH-------------------WATGNWDLCSTSCGGGFQKRT 1495
Query: 1207 VSCRDENGSVA---DESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQV 1263
V C G+ D+ C PRP ++C+ C + S + C T+
Sbjct: 1496 VQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACKK-------SADLLC-----TKDK 1543
Query: 1264 MCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQ 1297
+ ++ + +C +P +C S CPQ
Sbjct: 1544 LSASFCQTLKAMKKCS---VPTVRAECCFS-CPQ 1573
Score = 123 bits (308), Expect = 2e-27
Identities = 70/233 (30%), Positives = 109/233 (46%), Gaps = 24/233 (10%)
Query: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNT 998
W V + SECS CGLG A + R++ T+ D C++ +P ++C
Sbjct: 1317 WIVGNWSECSTTCGLG--------AYWRRVECSTQMDSD--CAAIQRPDPAKRCHLR-PC 1365
Query: 999 GGWRYSAWTECSKSCDGGTQRRRAICVNTRNDV-LDDSKCTHQEKVT---IQRCSEFPCP 1054
GW+ W++CS++C GG + R CV++R+ L C + C+ PC
Sbjct: 1366 AGWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCE 1425
Query: 1055 QWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAG 1114
W+ WS+C +CG G + R V+C G +CD +PTS +C + C W G
Sbjct: 1426 AWQVEPWSQCSRSCGGGVQERGVFCPGG-------LCDWTKRPTSTMSCNEHLCCHWATG 1478
Query: 1115 PWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDND--CNAATRPTDTQDCELPSC 1165
W CS +CG G+Q R V+C+ D + C+ RP + + C +C
Sbjct: 1479 NWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 118 bits (296), Expect = 5e-26
Identities = 80/265 (30%), Positives = 116/265 (43%), Gaps = 43/265 (16%)
Query: 1472 DGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKI 1531
+G L + K L HG W G WS+CS +CG G R V C
Sbjct: 1296 EGFLLNASNYKQLTNGHGSAH--------WIVGNWSECSTTCGLGAYWRRVECST----- 1342
Query: 1532 ARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVD--DNKNE 1589
+++C RP+ + C C W+ W +C++ C G + R++ CVD D++N
Sbjct: 1343 QMDSDCAAIQRPDPAKRCHLRPCA--GWKVGNWSKCSRNCSGGFKIREIQCVDSRDHRN- 1399
Query: 1590 VHGARCD--VSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKE 1647
+ C P SC+ +PCE W WS+CS +CG G ++R V C G
Sbjct: 1400 LRPFHCQFLAGIPPPLSMSCNPEPCE-AWQVEPWSQCSRSCGGGVQERGVFCPG---GLC 1455
Query: 1648 NYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN 1707
++ +T++C + H C W GNW CS SCG G +R+VQC+ +
Sbjct: 1456 DWTKRPTSTMSC------NEHLC--------CHWATGNWDLCSTSCGGGFQKRTVQCVPS 1501
Query: 1708 -----EDQPSHLCHTDLKPEERKTC 1727
EDQ LC +P E K C
Sbjct: 1502 EGNKTEDQDQCLCDHKPRPPEFKKC 1526
Score = 114 bits (284), Expect = 1e-24
Identities = 68/200 (34%), Positives = 88/200 (44%), Gaps = 12/200 (6%)
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRES-CSLQPCEY 1614
+Y W+ W EC+ TCG G R + C+ + V CD +P R+ C + C
Sbjct: 825 MYFWQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Query: 1615 VWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
W GEW CS TCG G K+R V C + E +C P R
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQA----LPPTDCQHLLKPKTLLSCNR 940
Query: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
D + W VGNW CSVSCG GV RSV C N D+P C KP R C + C
Sbjct: 941 DILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEP---CDVTRKPNSRALC-GLQQC 996
Query: 1734 ELPQNCKEVKRLKGASEDGE 1753
P + + +K KG +G+
Sbjct: 997 --PSSRRVLKPNKGTISNGK 1014
Score = 110 bits (276), Expect = 1e-23
Identities = 55/174 (31%), Positives = 85/174 (48%), Gaps = 11/174 (6%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHG-HRKCRGGRC-PKWK 1502
W G W+ CSV+CG G +++ +C+ K +++ +C +P+G +KC C P+W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 1503 AGAWSQCSVSCG-RGVQQRHVGC---QIGTHKIARETECNPYTRPESERDCQGPRCPLYT 1558
AG W CS +CG G ++R V C + + T+C +P++ C
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSD 947
Query: 1559 WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W W EC+ +CG G R R V C + H CDV+++P R C LQ C
Sbjct: 948 WTVGNWSECSVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQC 996
Score = 108 bits (269), Expect = 7e-23
Identities = 64/177 (36%), Positives = 83/177 (46%), Gaps = 14/177 (7%)
Query: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQ-CNTHACPHDAA 1444
W YG+W EC+ CG GIR + C + C+ +P R++ C+ ACP
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACP--PR 885
Query: 1445 WSTGPWSSCSVSCG-RGHKQRNVYC---MAKDGSHLESDYCKHLAKPHGHRKC-RGGRCP 1499
W G W +CS +CG G K+R V C M D L C+HL KP C R CP
Sbjct: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCP 945
Query: 1500 K-WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
W G WS+CSVSCG GV+ R V C + C+ +P S C +CP
Sbjct: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAKN-----HDEPCDVTRKPNSRALCGLQQCP 997
Score = 101 bits (251), Expect = 8e-21
Identities = 61/208 (29%), Positives = 82/208 (39%), Gaps = 47/208 (22%)
Query: 1242 WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD-CSMSPCPQRTP 1300
W+ W+ CSVTCG G + C+ ++ + CD + P Q C CP R
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPR-- 885
Query: 1301 DSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAG-GSQRRVVVC---- 1355
W G W ACS+TC G ++R V+C
Sbjct: 886 -------------------------------WWAGEWEACSATCGPHGEKKRTVLCIQTM 914
Query: 1356 -QDENGYTANDCVERIKPDEQRACESGP-CPQ-WAYGNWGECTKLCGGGIRTRLVVCQRS 1412
DE DC +KP +C CP W GNW EC+ CGGG+R R V C ++
Sbjct: 915 VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKN 974
Query: 1413 NGERFPDLSCEILDKPPDREQCNTHACP 1440
+ E C++ KP R C CP
Sbjct: 975 HDE-----PCDVTRKPNSRALCGLQQCP 997
Score = 98.6 bits (244), Expect = 5e-20
Identities = 62/192 (32%), Positives = 86/192 (44%), Gaps = 31/192 (16%)
Query: 1056 WKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLNDRMCDPETKPTSMQT-CQQPECAS-WQ 1112
W+ G W+EC VTCG G + + C + G + CDPET+P Q C + C W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 1113 AGPWGQCSVTCG-QGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELP----SCHP 1167
AG W CS TCG G + R V CI ++V D A PTD Q P SC+
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCI----QTMVSDEQ---ALPPTDCQHLLKPKTLLSCNR 940
Query: 1168 PPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPR 1227
P + W G+W+ CS +CG G R+R V+C + + C +
Sbjct: 941 DILCP-----------SDWTVGNWSECSVSCGGGVRIRSVTCAKNH-----DEPCDVTRK 984
Query: 1228 PVAKEECSVTPC 1239
P ++ C + C
Sbjct: 985 PNSRALCGLQQC 996
Score = 95.5 bits (236), Expect = 4e-19
Identities = 58/186 (31%), Positives = 86/186 (46%), Gaps = 22/186 (11%)
Query: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVT--IQRCSEFPCP-QWK 1057
W+Y WTECS +C G +R+ A C+ ++ + C + + ++C E CP +W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 1058 SGDWSECLVTCG-KGHKHRQVWC----QFGEDRLNDRMCDPETKPTSMQTCQQP-ECAS- 1110
+G+W C TCG G K R V C E L C KP ++ +C + C S
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSD 947
Query: 1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
W G W +CSV+CG G ++R+V C + D C+ +P C L C
Sbjct: 948 WTVGNWSECSVSCGGGVRIRSVTC------AKNHDEPCDVTRKPNSRALCGLQQC----- 996
Query: 1171 APETRR 1176
P +RR
Sbjct: 997 -PSSRR 1001
Score = 83.2 bits (204), Expect = 2e-15
Identities = 54/202 (26%), Positives = 80/202 (39%), Gaps = 35/202 (17%)
Query: 1186 WRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKE-ECSVTPC-GQWK 1243
W++G WT CS TCG G R + C + + + C +P ++ +C C +W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 1244 ALDWSSCSVTCG-QGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDS 1302
A +W +CS TCG G R V+C I D+ +P TD
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLC-------IQTMVSDEQALPPTD--------------- 925
Query: 1303 GLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYT 1362
QH +P++ +L + W G W CS +C GG + R V C +
Sbjct: 926 --CQHLL-----KPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHD-- 976
Query: 1363 ANDCVERIKPDEQRACESGPCP 1384
C KP+ + C CP
Sbjct: 977 -EPCDVTRKPNSRALCGLQQCP 997
Score = 66.2 bits (160), Expect = 3e-10
Identities = 48/182 (26%), Positives = 73/182 (40%), Gaps = 22/182 (12%)
Query: 885 GPWQACSKPCQGERK-RKLVCTRESDQLTVSDQRCDRLPQ-PGHITEPCGTDCDLRWHVA 942
G W CS+ C G K R++ C D + C L P ++ C + W V
Sbjct: 1371 GNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVE 1430
Query: 943 SRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWR 1002
S+CS CG G + ++C G C +P++ C+ E W
Sbjct: 1431 PWSQCSRSCGGGVQERGVFC-------------PGGLCDWTKRPTSTMSCN-EHLCCHWA 1476
Query: 1003 YSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSK---CTHQEK-VTIQRCSEFPCPQWKS 1058
W CS SC GG Q+R CV + + +D C H+ + ++C++ C KS
Sbjct: 1477 TGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQACK--KS 1534
Query: 1059 GD 1060
D
Sbjct: 1535 AD 1536
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 476 bits (1224), Expect = e-133
Identities = 335/1052 (31%), Positives = 498/1052 (47%), Gaps = 117/1052 (11%)
Query: 46 SEYEIVSPIRVNALGEPFPTNVHFKRTR---RSINSATDPWPAFASSSSSSTSSQAHYRL 102
+E + P+R +A G V +R R+ +A P+F + S Y +
Sbjct: 54 AERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNV 113
Query: 103 SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEH 162
+ FG+ L NA +AP T+ G G + E L C Y G V +E
Sbjct: 114 TVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV------EPLLGSCLYVGDVAGLAEA 167
Query: 163 TAV-ISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRH 221
++V +S C G+ G R + ++FIEPL+ E EQ + H++YRR P P G
Sbjct: 168 SSVALSNCDGLAGLIRMEEEEFFIEPLEK-GLAAQEAEQGRVHVVYRRP-PTSPPLGGPQ 225
Query: 222 ACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRT 281
A DT S D + +R G + N +
Sbjct: 226 ALDTGA-----SLDSLDSLSRALG-------------------VLEEHANSS-------- 253
Query: 282 HRRTKRFLSYPRF-VEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLINI 339
RR +R + + +EVL+ D+ +V +HG E++Q Y+LTLM+IV IY D S+G IN+
Sbjct: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
Query: 340 VIVNLIVIHNEQDGPSISF-NAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLTRQDICR 395
V+V +I++ + I N +L+N C+W + + P H HD A+ LTRQD
Sbjct: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
Query: 396 AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEG 454
G A + +C P RSC+++ + G S+AF +AHE GHV M HD N+C +E
Sbjct: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEV 429
Query: 455 VKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGIL 514
+MAP + + + WS+CS++ ++ +L + +CLL++P + +P QLPG+
Sbjct: 430 RLGS--IMAPLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQLPGLH 485
Query: 515 YNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKH 571
Y++N+QC FG G +C C++LWC++ + + C+T+ P DGT C PGKH
Sbjct: 486 YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKH 544
Query: 572 CKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRR 631
C G C+ D+ DGSWG+WSPFG+CSRTCG G+K R+C+ P P NGG+ C G
Sbjct: 545 CFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLA 604
Query: 632 MKFKSCNTEPCLKQKRDFRDEQC-------AHFDGKHFNINGLLPNVRWVPKYSGILMKD 684
F+ C+ + C DFR+EQC H D +H W+P + K+
Sbjct: 605 YDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQH----------HWLP-HEHRDAKE 653
Query: 685 RCKLFCRVAGNTAYYQLRDRVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCG 743
RC L+C ++ V DGT C +D +CV+G CR+ GCD V+ S + DKCG
Sbjct: 654 RCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCG 713
Query: 744 VCGGDNSSCKTVAGTF--NTVHYGYNTVVRIPAGATNIDVRQHSFSGETD-DDNYLALSS 800
VCGGDNS CK V GTF + +GY + IPAGA +H E D ++LA+ +
Sbjct: 714 VCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGA------RHLLIQEVDATSHHLAVKN 767
Query: 801 -SKGEFLLN-GNFVVTMAKREIRIGNAVVEYS-GSETAVERINSTDRIEQELLLQVLSVG 857
G+F+LN N V +K I +G VE+ E E + + + + + V+ VG
Sbjct: 768 LETGKFILNEENDVDASSKTFIAMG---VEWEYRDEDGRETLQTMGPLHGTITVLVIPVG 824
Query: 858 ----------KLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPC-QGERKRKLVCTR 906
++ + N +E+ + W + W CSKPC G + K C R
Sbjct: 825 DTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEW-ALKKWSPCSKPCGGGSQFTKYGCRR 883
Query: 907 ESDQLTVSDQRCDRLPQPGHITEPCG-TDCDLR-WHVASRSECSAQCG-LGYRTLDIYCA 963
D V C L +P I C +C W CS CG G + + C
Sbjct: 884 RLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCI 943
Query: 964 KYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAI 1023
+ D T V C+ +P +R CS E G WR W++CS +C GTQ R +
Sbjct: 944 QPLH-DNTTRSVHAKHCND-ARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVL 1001
Query: 1024 CVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQ 1055
C T +D C + T + C PCP+
Sbjct: 1002 C-RTADDSF--GICQEERPETARTCRLGPCPR 1030
Score = 108 bits (269), Expect = 7e-23
Identities = 65/177 (36%), Positives = 88/177 (49%), Gaps = 11/177 (6%)
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVD--DNKNEVHGARCDVSKRPVDRESCSLQPCE 1613
+Y W ++W C+K CG GS++ K C D+K G +SK R +C+ Q C
Sbjct: 855 VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
Query: 1614 Y-VWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCY 1671
VW+TGEW CS TCG+ G + R V C I +N S +C +P S C
Sbjct: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRC--IQPLHDNTTRSVHAK-HCNDARPESRRACS 971
Query: 1672 LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCR 1728
CP WR G W CSV+CG G +R V C T +D +C + +PE +TCR
Sbjct: 972 RELCP--GRWRAGPWSQCSVTCGNGTQERPVLCRTADDS-FGICQEE-RPETARTCR 1024
Score = 104 bits (260), Expect = 7e-22
Identities = 60/184 (32%), Positives = 84/184 (45%), Gaps = 18/184 (9%)
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGT-HKIARETECNPYTRPES-ERDCQGPRCPLY 1557
+W WS CS CG G Q GC+ HK+ C ++P++ R C C
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
Query: 1558 TWRAEEWQECTKTCGE-GSRYRKVVCV----DDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W EW+ C++TCG G + R V C+ D+ VH C+ RP R +CS + C
Sbjct: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELC 975
Query: 1613 EYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
W G WS+CSVTCG G ++R V C T +++ C +P + C L
Sbjct: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCR---TADDSFGI-------CQEERPETARTCRL 1025
Query: 1673 RDCP 1676
CP
Sbjct: 1026 GPCP 1029
Score = 98.6 bits (244), Expect = 5e-20
Identities = 64/214 (29%), Positives = 89/214 (41%), Gaps = 53/214 (24%)
Query: 1185 QWRFGSWTPCSATCGKGTRMRYVSCRDE-NGSVADESACATLPRPVA-KEECSVTPCGQ- 1241
+W W+PCS CG G++ CR + + CA L +P A + C+ C Q
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
Query: 1242 -WKALDWSSCSVTCGQ-GRATRQVMCV----NYSDHVIDRSECDQDYIPETDQDCSMSPC 1295
W +W CS TCG+ G R V C+ + + + C+ D PE+ + CS C
Sbjct: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELC 975
Query: 1296 PQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVC 1355
P R WR GPW CS TC G+Q R V+C
Sbjct: 976 PGR---------------------------------WRAGPWSQCSVTCGNGTQERPVLC 1002
Query: 1356 QDENGYTAND----CVERIKPDEQRACESGPCPQ 1385
+ TA+D C E +P+ R C GPCP+
Sbjct: 1003 R-----TADDSFGICQEE-RPETARTCRLGPCPR 1030
Score = 97.1 bits (240), Expect = 2e-19
Identities = 62/179 (34%), Positives = 80/179 (44%), Gaps = 19/179 (10%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAK-DGSHLESDYCKHLAKPHGHRK-CRGGRC--PK 1500
W+ WS CS CG G + C + D + +C L+KP R+ C C P
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 1501 WKAGAWSQCSVSCGR-GVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
W G W CS +CGR G+Q R V C T + CN RPES R C CP
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND-ARPESRRACSRELCP 976
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVC--VDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
WRA W +C+ TCG G++ R V+C DD+ +RP +C L PC
Sbjct: 977 -GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQ------EERPETARTCRLGPC 1028
Score = 92.4 bits (228), Expect = 4e-18
Identities = 60/180 (33%), Positives = 76/180 (42%), Gaps = 16/180 (8%)
Query: 1331 QWRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIKPDE-QRACESGPC--P 1384
+W W CS C GGSQ C+ D C KP +RAC C P
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
Query: 1385 QWAYGNWGECTKLCGG-GIRTRLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACP 1440
W G W C++ CG G++ R V C + N R +P R C+ CP
Sbjct: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP 976
Query: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
W GPWS CSV+CG G ++R V C D S C+ +P R CR G CP+
Sbjct: 977 --GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF---GICQE-ERPETARTCRLGPCPR 1030
Score = 90.9 bits (224), Expect = 1e-17
Identities = 66/218 (30%), Positives = 90/218 (41%), Gaps = 25/218 (11%)
Query: 1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
W W CS CG G Q C +V C A ++P + +C+P
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRR----ACNPQEC 913
Query: 1171 APETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRD---ENGSVADESACATLP 1226
+ W G W PCS TCG+ G ++R V C +N + + +
Sbjct: 914 SQPV-----------WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA 962
Query: 1227 RPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPE 1285
RP ++ CS C G+W+A WS CSVTCG G R V+C D C Q+ PE
Sbjct: 963 RPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF---GIC-QEERPE 1018
Query: 1286 TDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSR 1323
T + C + PCP+ D + Q RP SP R
Sbjct: 1019 TARTCRLGPCPRNISDPSKKSYVVQWLS-RPDPDSPIR 1055
Score = 88.2 bits (217), Expect = 7e-17
Identities = 63/197 (31%), Positives = 90/197 (45%), Gaps = 37/197 (18%)
Query: 1055 QWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRM-----CDPETKPTSM-QTCQQPEC 1108
+W WS C CG G + + C+ RL+ +M C +KP ++ + C EC
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCR---RRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
Query: 1109 AS--WQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
+ W G W CS TCG+ G Q+R+V+CI + DN TR + C
Sbjct: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCI-----QPLHDN----TTRSVHAKHCN---- 960
Query: 1166 HPPPAAPETRRS-TYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR--DENGSVADESAC 1222
A PE+RR+ + +WR G W+ CS TCG GT+ R V CR D++ + E
Sbjct: 961 ---DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-- 1015
Query: 1223 ATLPRPVAKEECSVTPC 1239
RP C + PC
Sbjct: 1016 ----RPETARTCRLGPC 1028
Score = 83.2 bits (204), Expect = 2e-15
Identities = 58/182 (31%), Positives = 79/182 (43%), Gaps = 28/182 (15%)
Query: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQ--------EKVTIQRCSEFP 1052
W W+ CSK C GG+Q + C D K H+ K + C+
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRL-----DHKMVHRGFCAALSKPKAIRRACNPQE 912
Query: 1053 C--PQWKSGDWSECLVTCGK-GHKHRQVWC-QFGEDR----LNDRMCDPETKPTSMQTCQ 1104
C P W +G+W C TCG+ G + R V C Q D ++ + C+ + +P S + C
Sbjct: 913 CSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACS 971
Query: 1105 QPECAS-WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELP 1163
+ C W+AGPW QCSVTCG G Q R V C + D RP + C L
Sbjct: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVLC-----RTADDSFGICQEERPETARTCRLG 1026
Query: 1164 SC 1165
C
Sbjct: 1027 PC 1028
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 469 bits (1206), Expect = e-131
Identities = 341/1104 (30%), Positives = 518/1104 (46%), Gaps = 171/1104 (15%)
Query: 47 EYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFG 106
EYE+V+P+ N G + +RS SS Q + ++AFG
Sbjct: 41 EYELVTPVSTNLEGRYLSHTLSASHKKRSARDV------------SSNPEQLFFNITAFG 88
Query: 107 QQFLFNLTANAGFIAPLFTVTLLGT---------------PGVNQTKFYSEEEAELKHCF 151
+ F L N +AP V T PG + E + +C
Sbjct: 89 KDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQT-NCA 147
Query: 152 YKGYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSA 211
Y G + + IS C G+ G +S + +YFIEPL+ + E EE+ + H++Y+RSA
Sbjct: 148 YVGDIVDIPGTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQME--EEKGRIHVVYKRSA 205
Query: 212 PQREPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGN 271
++ P D S K+ H ++ D+ L+ + + YGN
Sbjct: 206 VEQAP------IDMS--KDFHYRES----------------DLEGLD-----DLGTVYGN 236
Query: 272 KTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKD 330
E RR Y +EVL+ D+ +V +HG E++Q+Y+LTLM+IV IY D
Sbjct: 237 IHQQLNETMRRRRHAGENDYN--IEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHD 294
Query: 331 PSIGNLINIVIVNLIVIHNEQDGPSISF----NAQTTLKNFCQW---QHSKNSPGGIHHD 383
S+G IN+V+V +I++ + SIS N +L+N C+W Q + HHD
Sbjct: 295 ESLGVHINVVLVRMIMLGYAK---SISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHD 351
Query: 384 TAVLLTRQDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMP 443
A+ LTRQD A + G A + +C P RSC+++ + G S+AF +AHE GHV M
Sbjct: 352 HAIFLTRQDFGPAGMQ----GYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGME 407
Query: 444 HD-DNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESR 502
HD N+C +E VMAP + + + WS+CS + + ++ + +CLL++P
Sbjct: 408 HDGQGNRCGDETAMGS--VMAPLVQAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDH 463
Query: 503 PYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTP 559
+P +LPGI Y++++QC FG G ++C C++LWC++ + + C+T+ P
Sbjct: 464 DWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGP 522
Query: 560 WADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPE 619
DGTEC GK C G C+ K + DG+WGSW+ FG+CSRTCG G++ R+CN P
Sbjct: 523 PLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPM 582
Query: 620 PKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSG 679
P NGG+ C G +++ CNTE C K DFR +QC + HF + W+P Y
Sbjct: 583 PINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQCQQRNS-HFEYQNTKHH--WLP-YEH 638
Query: 680 ILMKDRCKLFC--RVAGNTAYYQLRDRVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSK 736
K RC L+C + G+ AY ++ V DGT C +D ICV+G C + GCD + S
Sbjct: 639 PDPKKRCHLYCQSKETGDVAY--MKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSN 696
Query: 737 ARRDKCGVCGGDNSSCKTVAGTFNTV--HYGYNTVVRIPAGATNIDVRQHSFSGETDDDN 794
DKCGVCGGDNS C+TV GTF GY + IP GA ++ +++ S +
Sbjct: 697 KVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEAS-----PH 751
Query: 795 YLALSS-SKGEFLLNGNFVVTMAKREIRIGNAVVEYSGS-ETAVERINSTDRIEQELLLQ 852
LA+ + + G ++LNG ++ I +G VE+ + E +E +++ + +++
Sbjct: 752 ILAIKNQATGHYILNGKGEEAKSRTFIDLG---VEWDYNIEDDIESLHTDGPLHDPVIVL 808
Query: 853 VLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLT 912
++ + Y + I + P T
Sbjct: 809 IIPQENDTRSSLTYKYIIHEDSVP-----------------------------------T 833
Query: 913 VSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKT 972
++ I E T W + S S+CS CG G++ C + S
Sbjct: 834 INSNNV--------IQEELDT---FEWALKSWSQCSKPCGGGFQYTKYGCRRKS----DN 878
Query: 973 EKVDDGFCSSHPKPSN-REKCS-GECNTGGWRYSAWTECSKSC-DGGTQRRRAICVNT-- 1027
+ V FC ++ KP R C+ EC W W C+K+C G Q R C+
Sbjct: 879 KMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLL 938
Query: 1028 --RNDVLDDSKCTHQEKVTIQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQVWCQFGED 1084
N + C + + C+ PCP QWK+G WSEC VTCG+G + RQV C+ G+
Sbjct: 939 DGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDH 998
Query: 1085 RLNDRMCDPETKPTSMQTCQQPEC 1108
CD E KP S++ CQ P C
Sbjct: 999 ------CDGE-KPESVRACQLPPC 1015
Score = 116 bits (290), Expect = 2e-25
Identities = 67/183 (36%), Positives = 86/183 (46%), Gaps = 22/183 (12%)
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGT-HKIARETECNPYTRPES-ERDCQGPRCPLY 1557
+W +WSQCS CG G Q GC+ + +K+ + C +P+ R C C
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 1558 TWRAEEWQECTKTCGE-GSRYRKVVCV----DDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W AEEW+ CTKTCG G + R V C+ D VH C + RP R C+ PC
Sbjct: 908 LWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC-MGDRPESRRPCNRVPC 966
Query: 1613 EYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
W TG WSECSVTCG+G + R V C + +C G +P SV C L
Sbjct: 967 PAQWKTGPWSECSVTCGEGTEVRQVLC--------------RAGDHCDGEKPESVRACQL 1012
Query: 1673 RDC 1675
C
Sbjct: 1013 PPC 1015
Score = 107 bits (266), Expect = 1e-22
Identities = 61/178 (34%), Positives = 88/178 (49%), Gaps = 19/178 (10%)
Query: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNE-VHGARCDVSKRPVD-RESCSLQPCEY 1614
+ W + W +C+K CG G +Y K C + N+ VH + C+ +K+P R C++Q C +
Sbjct: 847 FEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTH 906
Query: 1615 -VWITGEWSECSVTCGK-GYKQRLVSCSE-IYTGKENYEYSYQTTINCPGTQPPSVHPCY 1671
+W+ EW C+ TCG GY+ R V C + + G +S C G +P S PC
Sbjct: 907 PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKY----CMGDRPESRRPCN 962
Query: 1672 LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTD-LKPEERKTCR 1728
CP A W+ G W CSV+CG G R V C + H D KPE + C+
Sbjct: 963 RVPCP--AQWKTGPWSECSVTCGEGTEVRQVLCRAGD-------HCDGEKPESVRACQ 1011
Score = 95.9 bits (237), Expect = 3e-19
Identities = 61/203 (30%), Positives = 95/203 (46%), Gaps = 28/203 (13%)
Query: 982 SHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVN-TRNDVLDDSKCTHQ 1040
S P ++ E +T W +W++CSK C GG Q + C + N ++ S C
Sbjct: 830 SVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEAN 889
Query: 1041 EK-------VTIQRCSEFPCPQWKSGDWSECLVTCGK-GHKHRQVWCQF----GEDR-LN 1087
+K IQ C+ P W + +W C TCG G++ R V C G +R ++
Sbjct: 890 KKPKPIRRMCNIQECTH---PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVH 946
Query: 1088 DRMCDPETKPTSMQTCQQPEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDN 1146
+ C + +P S + C + C A W+ GPW +CSVTCG+G ++R V C G +
Sbjct: 947 SKYCMGD-RPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHCD----- 1000
Query: 1147 DCNAATRPTDTQDCELPSCHPPP 1169
+P + C+LP C+ P
Sbjct: 1001 ----GEKPESVRACQLPPCNDEP 1019
Score = 93.2 bits (230), Expect = 2e-18
Identities = 60/177 (33%), Positives = 78/177 (44%), Gaps = 19/177 (10%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAK-DGSHLESDYCKHLAKPHGHRK-CRGGRC--PK 1500
W+ WS CS CG G + C K D + +C+ KP R+ C C P
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 1501 WKAGAWSQCSVSCG-RGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
W A W C+ +CG G Q R V C GT++ C RPES R C CP
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMG-DRPESRRPCNRVPCP 967
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W+ W EC+ TCGEG+ R+V+C G CD ++P +C L PC
Sbjct: 968 A-QWKTGPWSECSVTCGEGTEVRQVLC-------RAGDHCD-GEKPESVRACQLPPC 1015
Score = 92.0 bits (227), Expect = 5e-18
Identities = 126/488 (25%), Positives = 168/488 (34%), Gaps = 112/488 (22%)
Query: 1104 QQPECASWQAGPW---GQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC---NAATRPTDT 1157
QQ + +W G W G CS TCG G + R +C M + DC N + +T
Sbjct: 547 QQKQDGNW--GSWTKFGSCSRTCGTGVRFRTRQC--NNPMPINGGQDCPGVNFEYQLCNT 602
Query: 1158 QDCE---------------------------LPSCHPPPA--------APETRRSTYSAP 1182
++C+ LP HP P + ET Y
Sbjct: 603 EECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQ 662
Query: 1183 RTQWRFGSWTPCS-----ATCGKGTRMRYVSCRDENGSV----------ADESACATL-- 1225
T CS + C +G ++ V C E GS D S C T+
Sbjct: 663 LVH----DGTHCSYKDPYSICVRGECVK-VGCDKEIGSNKVEDKCGVCGGDNSHCRTVKG 717
Query: 1226 -----PRPVAKEECSVTPCGQWKAL---DWSSCSVTCGQGRATRQVMCVNYSDHVIDRSE 1277
PR + + P G L D +S + + +AT + + R+
Sbjct: 718 TFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTF 777
Query: 1278 CDQ----DYIPETDQDCSMSPCPQRTP------------DSGLAQHPFQNEDYRPRSASP 1321
D DY E D + + P P S L +ED P S
Sbjct: 778 IDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSN 837
Query: 1322 SRTHV-LGGNQWRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIKPDE-QR 1376
+ L +W W CS C GG Q C+ D + C KP +R
Sbjct: 838 NVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRR 897
Query: 1377 ACESGPC--PQWAYGNWGECTKLCGG-GIRTRLVVCQR---SNGERFPDLSCEILDKPPD 1430
C C P W W CTK CG G + R V C + R + D+P
Sbjct: 898 MCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPES 957
Query: 1431 REQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGH 1490
R CN CP A W TGPWS CSV+CG G + R V C A G H + + KP
Sbjct: 958 RRPCNRVPCP--AQWKTGPWSECSVTCGEGTEVRQVLCRA--GDHCDGE------KPESV 1007
Query: 1491 RKCRGGRC 1498
R C+ C
Sbjct: 1008 RACQLPPC 1015
Score = 35.0 bits (79), Expect = 0.71
Identities = 28/98 (28%), Positives = 41/98 (41%), Gaps = 16/98 (16%)
Query: 1623 ECSVTCGKGYK-----QRLVSCSEIYTGKENYEYSYQTTINCP--GTQPPSVHPCYLRDC 1675
+C G GYK + C +++ + Y +T P GT+ + CY C
Sbjct: 481 QCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHC 540
Query: 1676 P---VSATWRVGNWGS------CSVSCGVGVMQRSVQC 1704
+ + GNWGS CS +CG GV R+ QC
Sbjct: 541 MWKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQC 578
Score = 34.7 bits (78), Expect = 0.93
Identities = 19/54 (35%), Positives = 24/54 (44%)
Query: 596 PFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDF 649
P+ CS TCG G + C + +G K R + CN EPCL K F
Sbjct: 974 PWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESVRACQLPPCNDEPCLGDKSIF 1027
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 441 bits (1133), Expect = e-123
Identities = 335/1111 (30%), Positives = 490/1111 (44%), Gaps = 157/1111 (14%)
Query: 43 ETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRL 102
+ ++ E+V P RV P RR T P A+ + L
Sbjct: 30 DAAADVEVVLPWRVRPDDVHLPPLPAAPGPRRRRRPRTPP----AAPRARPGERALLLHL 85
Query: 103 SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEH 162
AFG+ L + F++ F V G AEL CFY G V +
Sbjct: 86 PAFGRDLYLQLRRDLRFLSRGFEVEEAGAARRRG------RPAEL--CFYSGRVLGHPGS 137
Query: 163 TAVISLCS---GMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTG 219
+S C G++G + I+PL + E H+I R+ + PS
Sbjct: 138 LVSLSACGAAGGLVGLIQLGQEQVLIQPLNNSQGPFSGRE----HLIRRKWSLTPSPSA- 192
Query: 220 RHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREK 279
E + +KKK +G + + RE+
Sbjct: 193 --EAQRPEQLCKVLTEKKKP----------------------------TWGRPSRDWRER 222
Query: 280 RTHRRTKRFLSYPRFVEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLIN 338
R R L+ VE LVVAD MV YHG E Q +ILT+M++V ++++ S+G IN
Sbjct: 223 RNAIR----LTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKIN 278
Query: 339 IVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNS----------PGGIHH----DT 384
I + L+++ SI + + +L++FC WQ+ + PGG D
Sbjct: 279 IQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDA 338
Query: 385 AVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMP 443
AV +TR D C D+ CDT+G+A LG +C R C ++ED+GL+ AFTIAHELGH M
Sbjct: 339 AVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMN 398
Query: 444 HDDNNKCKEEGVKSPQHVMAPTLNFYTNP--WMWSKCSRKYITEFLDTGYGECLL-NEPE 500
HDD++ H+M+ NP WS CSR + FL + CLL +P
Sbjct: 399 HDDDHS----SCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPR 454
Query: 501 SR-PYPLPVQLPGILYNVNKQCELIFGPGSQVCPYM--MQCRRLWCNNVNGVHKGCRTQH 557
S+ LP +LPG+ Y+ N+QC+++FG + C M + C LWC V G C+T+
Sbjct: 455 SQHTVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHLMCAGLWCL-VEG-DTSCKTKL 512
Query: 558 TPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNR 617
P DGTEC K C+ G CV K DG W W + CSRTCG G + R+C+
Sbjct: 513 DPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDN 572
Query: 618 PEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKY 677
P P GG +C G ++ C PC K FRD+QC D GLL
Sbjct: 573 PPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLL--------- 623
Query: 678 SGILMKDR-CKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSK 736
+ +++ D+ C+L+C G + + DRV+DGTPCG D+CV G C++ GCD ++ S
Sbjct: 624 TAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSA 683
Query: 737 ARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYL 796
A+ D+CGVC GD +C V G F+ + T ++ S G + D +
Sbjct: 684 AKEDRCGVCSGDGKTCHLVKGDFS---HARGTALK------------DSGKGSINSDWKI 728
Query: 797 ALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSV 856
L GEF + G V R +R G E+I++ + L L VL
Sbjct: 729 ELP---GEFQIAGTTV-----RYVRRG-----------LWEKISAKGPTKLPLHLMVLL- 768
Query: 857 GKLYNPD--VRYSFNIPIE---------DKPQQ--FYWNSHGPWQACSKPCQGERKRKLV 903
++ D + Y + +P+ +KPQ F W +H W+ CS C G +R +V
Sbjct: 769 --FHDQDYGIHYEYTVPVNRTAENQSEPEKPQDSLFIW-THSGWEGCSVQCGGGERRTIV 825
Query: 904 -CTRESDQLT--VSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTLD 959
CTR ++ T V+D C + +P C C RW S CSA C G++ +
Sbjct: 826 SCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHRE 885
Query: 960 IYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQR 1019
+ C Y +G +C P+P+ + C G+ W S W++CS SC G +
Sbjct: 886 VTCV-YQLQNGTHVATRPLYCPG-PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWK 943
Query: 1020 RRAICVNTRNDVLDDSKCTHQEKVTIQR-CSEFP-CPQWKSGDWSECLVTCGKGHKHRQV 1077
R C N++ KC + + C ++ C +WK+GDWS C TCGKG + R V
Sbjct: 944 RTVACTNSQG------KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVV 997
Query: 1078 WCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
C + C +KP + C Q C
Sbjct: 998 QCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 149 bits (375), Expect = 3e-35
Identities = 85/241 (35%), Positives = 113/241 (46%), Gaps = 26/241 (10%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYC---MAKDGSHLESDYCKHLAKPHGH-RKCRGGRCP- 1499
W+ W CSV CG G ++ V C + K + + C ++P R+C C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
+W AG WS CS +C +G Q R V C Q GTH R C P RP + + C+G C
Sbjct: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC-PGPRPAAVQSCEGQDC- 921
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
L W A EW +C+ +CG+G R V C + +CD S RP E+C Y
Sbjct: 922 LSIWEASEWSQCSASCGKGVWKRTVACTNSQ------GKCDASTRPRAEEACEDYSGCYE 975
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPG-TQPPSVHPCYLRD 1674
W TG+WS CS TCGKG + R+V C TG+ E CP ++P CY
Sbjct: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSE--------CPALSKPAPYRQCYQEV 1027
Query: 1675 C 1675
C
Sbjct: 1028 C 1028
Score = 140 bits (352), Expect = 2e-32
Identities = 78/236 (33%), Positives = 111/236 (47%), Gaps = 20/236 (8%)
Query: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFP---DLSCEILDKP-PDREQCNTHACPH 1441
W + W C+ CGGG R +V C R + D C +P P +CN H C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC-- 861
Query: 1442 DAAWSTGPWSSCSVSCGRGHKQRNVYCM--AKDGSHLESD--YCKHLAKPHGHRKCRGGR 1497
+ W GPWS CS +C +G + R V C+ ++G+H+ + YC +P + C G
Sbjct: 862 QSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG-PRPAAVQSCEGQD 920
Query: 1498 CPK-WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPL 1556
C W+A WSQCS SCG+GV +R V C K C+ TRP +E C+
Sbjct: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK------CDASTRPRAEEACE-DYSGC 973
Query: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Y W+ +W C+ TCG+G + R V C+ HG+ C +P C + C
Sbjct: 974 YEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR-HGSECPALSKPAPYRQCYQEVC 1028
Score = 133 bits (335), Expect = 1e-30
Identities = 88/280 (31%), Positives = 119/280 (42%), Gaps = 62/280 (22%)
Query: 1111 WQAGPWGQCSVTCGQGYQLRAVKC--IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
W W CSV CG G + V C I+ ++V+D+DC A+RP
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPE------------- 850
Query: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--RDENGS-VADESACATL 1225
P+ RR +++W G W+PCSATC KG + R V+C + +NG+ VA
Sbjct: 851 ---PQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPG 907
Query: 1226 PRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
PRP A + C C W+A +WS CS +CG+G R V C N + +CD P
Sbjct: 908 PRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTN------SQGKCDASTRP 961
Query: 1285 ETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTC 1344
++ C EDY G +W+TG W CSSTC
Sbjct: 962 RAEEAC---------------------EDYS------------GCYEWKTGDWSTCSSTC 988
Query: 1345 AGGSQRRVVVCQDE-NGYTANDCVERIKPDEQRACESGPC 1383
G Q RVV C + G ++C KP R C C
Sbjct: 989 GKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 120 bits (300), Expect = 2e-26
Identities = 115/463 (24%), Positives = 172/463 (37%), Gaps = 70/463 (15%)
Query: 1318 SASPSRTHVLGG-NQWRTGPWGACSSTCAGGSQRRVVVCQDEN-GYTANDCVERIKPDEQ 1375
S +P HV G + W G W CS TC G++ R C + G C E
Sbjct: 534 SKTPIPEHVDGDWSPW--GAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASV--EH 589
Query: 1376 RACESGPCPQW----------AYGNWGECTKLCGGGIRTRLVV----CQRSNGERFPDLS 1421
CE+ PCP+ A+ K G+ T +VV C+ +
Sbjct: 590 AVCENLPCPKGLPSFRDQQCQAHDRLSPKKK----GLLTAVVVDDKPCELYCSPLGKESP 645
Query: 1422 CEILDKPPDREQCN---THACPHDAAWSTG---------PWSSCSVSCGRGHKQRNVYCM 1469
+ D+ D C T C H G C V G G + + +
Sbjct: 646 LLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCSGDG---KTCHLV 702
Query: 1470 AKDGSHLESDYCKHLAKPH----------GHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQ 1519
D SH K K G + G + G W + S +
Sbjct: 703 KGDFSHARGTALKDSGKGSINSDWKIELPGEFQIAGTTVRYVRRGLWEKISAKGPTKLPL 762
Query: 1520 RHVGCQIGTHKIARETECNPYTRP-----ESERDCQGPRCPLYTWRAEEWQECTKTCGEG 1574
+ E YT P E++ + + P+ L+ W W+ C+ CG G
Sbjct: 763 HLMVLLFHDQDYGIHYE---YTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGG 819
Query: 1575 SRYRKVVC---VDDNKNEVHGARCDVSKRPVDR-ESCSLQPCEYVWITGEWSECSVTCGK 1630
R V C V+ V+ + C + RP + C+L PC+ W+ G WS CS TC K
Sbjct: 820 ERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEK 879
Query: 1631 GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCS 1690
G++ R V+C +Y +N + + CPG +P +V C +DC + W W CS
Sbjct: 880 GFQHREVTC--VYQ-LQNGTHVATRPLYCPGPRPAAVQSCEGQDC--LSIWEASEWSQCS 934
Query: 1691 VSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
SCG GV +R+V C ++ + C +P + C + C
Sbjct: 935 ASCGKGVWKRTVACTNSQGK----CDASTRPRAEEACEDYSGC 973
Score = 118 bits (295), Expect = 6e-26
Identities = 76/264 (28%), Positives = 113/264 (42%), Gaps = 29/264 (10%)
Query: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFC--SSHPKPSNREKCSGEC 996
W + CS QCG G R + C + ++ T V+D C +S P+P R +C+
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRI--VNKTTTLVNDSDCPQASRPEPQVR-RCNLHP 860
Query: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICV----NTRNDVLDDSKCTHQEKVTIQRCSEFP 1052
W W+ CS +C+ G Q R CV N + C +Q C
Sbjct: 861 CQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQD 920
Query: 1053 CPQ-WKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPE-CAS 1110
C W++ +WS+C +CGKG R V C + + CD T+P + + C+ C
Sbjct: 921 CLSIWEASEWSQCSASCGKGVWKRTVACTNSQGK-----CDASTRPRAEEACEDYSGCYE 975
Query: 1111 WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHP 1167
W+ G W CS TCG+G Q R V+C + G + S +C A ++P + C C+
Sbjct: 976 WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGS-----ECPALSKPAPYRQCYQEVCND 1030
Query: 1168 -----PPAAPETRRSTYSAPRTQW 1186
+P TY R QW
Sbjct: 1031 RINANTITSPRLAALTYKCTRDQW 1054
Score = 117 bits (294), Expect = 8e-26
Identities = 69/212 (32%), Positives = 101/212 (47%), Gaps = 22/212 (10%)
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHK---IARETECNPYTRPESE-RDCQGPRCPL 1556
W W CSV CG G ++ V C +K + +++C +RPE + R C C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDV---SKRPVDRESCSLQPCE 1613
W A W C+ TC +G ++R+V CV +N H A + RP +SC Q C
Sbjct: 864 -RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL 922
Query: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
+W EWS+CS +CGKG +R V+C+ GK + T+P + C
Sbjct: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQ-GKCD-----------ASTRPRAEEAC--E 968
Query: 1674 DCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL 1705
D W+ G+W +CS +CG G+ R VQC+
Sbjct: 969 DYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCM 1000
Score = 110 bits (275), Expect = 1e-23
Identities = 81/295 (27%), Positives = 111/295 (37%), Gaps = 52/295 (17%)
Query: 1186 WRFGSWTPCSATCGKGTRMRYVSCR---DENGSVADESACATLPRPVAK-EECSVTPC-G 1240
W W CS CG G R VSC ++ ++ ++S C RP + C++ PC
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQS 863
Query: 1241 QWKALDWSSCSVTCGQGRATRQVMCV---NYSDHVIDRSECDQDYIPETDQDCSMSPCPQ 1297
+W A WS CS TC +G R+V CV HV R P Q C C
Sbjct: 864 RWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL- 922
Query: 1298 RTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQD 1357
+ W W CS++C G +R V C +
Sbjct: 923 --------------------------------SIWEASEWSQCSASCGKGVWKRTVACTN 950
Query: 1358 ENGYTANDCVERIKPDEQRACES-GPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
G C +P + ACE C +W G+W C+ CG G+++R+V C R
Sbjct: 951 SQG----KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR 1006
Query: 1417 FPDLSCEILDKPPDREQCNTHACPH--DAAWSTGP-WSSCSVSCGRGHKQRNVYC 1468
C L KP QC C +A T P ++ + C R Q VYC
Sbjct: 1007 HGS-ECPALSKPAPYRQCYQEVCNDRINANTITSPRLAALTYKCTR--DQWTVYC 1058
Score = 42.0 bits (97), Expect = 0.006
Identities = 85/370 (22%), Positives = 125/370 (33%), Gaps = 66/370 (17%)
Query: 1419 DLSCEI-LDKPPDREQCN-------------THACPH-DAAWST-GPWSSCSVSCGRGHK 1462
D SC+ LD P D +C T H D WS G WS CS +CG G +
Sbjct: 505 DTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGAR 564
Query: 1463 QRNVYC----MAKDGSH-----LESDYCKHLAKPHGHRKCRGGRC-------PKWKAGAW 1506
R C G+H +E C++L P G R +C PK K
Sbjct: 565 FRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKKGLLT 624
Query: 1507 S------QCSVSCGRGVQQRHVGCQIGTHKIARETECNPY-TRPESERDCQGPRCPLYTW 1559
+ C + C ++ + + ++ T C PY T CQ C
Sbjct: 625 AVVVDDKPCELYCSPLGKESPL---LVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIG 681
Query: 1560 RAEEWQEC------TKTC----GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
A + C KTC G+ S R D K ++ D +
Sbjct: 682 SAAKEDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINS---DWKIELPGEFQIAG 738
Query: 1610 QPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHP 1669
YV G W + S KG + + + ++Y Y+ T+ T P
Sbjct: 739 TTVRYV-RRGLWEKIS---AKGPTKLPLHLMVLLFHDQDYGIHYEYTVPVNRTAENQSEP 794
Query: 1670 CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHL-----CHTDLKPEER 1724
+D W W CSV CG G + V C ++ + L C +PE +
Sbjct: 795 EKPQDS--LFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQ 852
Query: 1725 KTCRNVYNCE 1734
N++ C+
Sbjct: 853 VRRCNLHPCQ 862
Score = 36.6 bits (83), Expect = 0.24
Identities = 40/154 (25%), Positives = 57/154 (37%), Gaps = 27/154 (17%)
Query: 1461 HKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWS--QCSVSCGRGVQ 1518
H N C G + + +C+++ H C AG W + SC +
Sbjct: 469 HYSANEQCQILFG--MNATFCRNME----HLMC---------AGLWCLVEGDTSCKTKLD 513
Query: 1519 QRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYR 1578
G + G K R EC T D G P W A W C++TCG G+R+R
Sbjct: 514 PPLDGTECGADKWCRAGECVSKTPIPEHVD--GDWSP---WGA--WSMCSRTCGTGARFR 566
Query: 1579 KVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
+ C D+ G C + V+ C PC
Sbjct: 567 QRKC-DNPPPGPGGTHCPGAS--VEHAVCENLPC 597
Score = 34.3 bits (77), Expect = 1.2
Identities = 16/50 (32%), Positives = 23/50 (46%), Gaps = 9/50 (18%)
Query: 1188 FGSWTPCSATCGKGTRMRYVSCRDE---------NGSVADESACATLPRP 1228
+G+W+ CS TCG G R R C + G+ + + C LP P
Sbjct: 549 WGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP 598
Score = 32.7 bits (73), Expect = 3.5
Identities = 22/73 (30%), Positives = 26/73 (35%), Gaps = 15/73 (20%)
Query: 1077 VWCQFGEDRLNDRMCDPETKPTSM---QTCQQPECAS-----------WQA-GPWGQCSV 1121
+WC D DP T + C+ EC S W G W CS
Sbjct: 498 LWCLVEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSR 557
Query: 1122 TCGQGYQLRAVKC 1134
TCG G + R KC
Sbjct: 558 TCGTGARFRQRKC 570
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 440 bits (1132), Expect = e-123
Identities = 313/1050 (29%), Positives = 483/1050 (46%), Gaps = 116/1050 (11%)
Query: 101 RLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKH---CFYKGYVN 157
R+ AF + L + F+AP F V PG T S + CFY G V
Sbjct: 168 RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL 227
Query: 158 TNSEHTAVISLCSG-MLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREP 216
+ A S C G ++G + ++ FIEPL + PH +YR+ E
Sbjct: 228 RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLN-----DTMAITGHPHRVYRQKRSMEEK 282
Query: 217 STGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNT 276
T + A + H DK + R+RK E +
Sbjct: 283 VTEKSALHS--HYCGIISDKGRPRSRKIAE----------------------------SG 312
Query: 277 REKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENL-QHYILTLMSIVASIYKDPSIGN 335
R KR + + + +E +VVAD MVSYHG + + +ILT++++V ++++ S+
Sbjct: 313 RGKRYSYKLPQEYN----IETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSV 368
Query: 336 LINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHH------------- 382
+N+ ++ LI++H I + + L++FC+WQH + H
Sbjct: 369 QVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTS 428
Query: 383 -DTAVLLTRQDICRAHDK-CDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVF 440
D A+L+TR+D C D+ CDT+G+A L +C R C I+ED+GL+ AFTIAHE+GH
Sbjct: 429 VDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNM 488
Query: 441 NMPHDDNNKCKEEG--VKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLN- 497
+ HD+++ +G + S + + L + WS+CS++ + FL + CLL
Sbjct: 489 GINHDNDHPSCADGLHIMSGEWIKGQNLGDVS----WSRCSKEDLERFLRSKASNCLLQT 544
Query: 498 EPES-RPYPLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ--CRRLWCNNVNGVHKGCR 554
P+S +P +LPG+ Y ++QC+++FGP + C M C LWC V G K CR
Sbjct: 545 NPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCK-VEG-EKECR 602
Query: 555 TQHTPWADGTECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRE 614
T+ P DGT+C+ GK CK G C + G W WSP CSRTC GI + R+
Sbjct: 603 TKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERK 659
Query: 615 CNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWV 674
C P + + C G R +++ C PC FRD QC + + + +L
Sbjct: 660 C--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHIL------ 711
Query: 675 PKYSGILMKDR-CKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVL 733
++ +L +++ C LFC G L ++V+DGT CG DIC G C++ GCD +L
Sbjct: 712 -QWQAVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLL 770
Query: 734 NSKARRDKCGVCGGDNSSCKTVAGTFN-TVHYGYNTVVRIPAGATNIDVRQHSFSGETDD 792
S AR D CGVC G+ SCK + G FN T GY V+ IPAGA I V + E
Sbjct: 771 GSLAREDHCGVCNGNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKVVE-----EKPA 825
Query: 793 DNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQ 852
+YLAL + G+ +N ++ + + + V Y E+I++ L L
Sbjct: 826 HSYLALRDA-GKQSINSDWKIEHS-GAFNLAGTTVHYV-RRGLWEKISAKGPTTAPLHLL 882
Query: 853 VLSVGKLYNPDVRYSFNIPIEDKPQQ---------FYWNSHGPWQACSKPC-QGERKRKL 902
VL + + N + Y + IP + P+ F W +H W+ C C GERK +
Sbjct: 883 VL-LFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMW-THTSWEDCDATCGGGERKTTV 940
Query: 903 VCTR--ESDQLTVSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTLD 959
CT+ + V +++C L +P C C RW + + CS CG G ++
Sbjct: 941 SCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQ 1000
Query: 960 IYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQR 1019
+ C + +G + + C PKP++ ++C G+ W W+ECS C G +
Sbjct: 1001 VACTQ-QLSNGTLIRARERDCIG-PKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRH 1058
Query: 1020 RRAICVNTRNDVLDDSKCTHQEKVTIQRCSEF-PCPQWKSGDWSECLVTCGKGHKHRQVW 1078
R C N R + ++ E C ++ C W+ GDWS+C +TCGKG + R +
Sbjct: 1059 RTVRCTNPRKKCVLSTRPREAED-----CEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQ 1113
Query: 1079 CQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
C + C KP + + C C
Sbjct: 1114 CMHKITGRHGNECFSSEKPAAYRPCHLQPC 1143
Score = 156 bits (395), Expect = 2e-37
Identities = 85/241 (35%), Positives = 126/241 (52%), Gaps = 26/241 (10%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYC---MAKDGSHLESDYCKHLAKPHGH-RKCRGGRCP- 1499
W+ W C +CG G ++ V C M+K+ S ++++ CK+L KP RKC C
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
+W W+ CS +CG+G+Q R V C GT ARE +C +P S + C+G C
Sbjct: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDC- 1036
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
+ W A W EC+ CG+G R+R V C + K +C +S RP + E C YV
Sbjct: 1037 MTVWEAGVWSECSVKCGKGIRHRTVRCTNPRK------KCVLSTRPREAEDCEDYSKCYV 1090
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVH-PCYLRD 1674
W G+WS+CS+TCGKG + R++ C TG+ E C ++ P+ + PC+L+
Sbjct: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE--------CFSSEKPAAYRPCHLQP 1142
Query: 1675 C 1675
C
Sbjct: 1143 C 1143
Score = 142 bits (358), Expect = 3e-33
Identities = 145/583 (24%), Positives = 221/583 (37%), Gaps = 77/583 (13%)
Query: 1077 VWCQFGEDRLNDRMCDPETKPTSMQT---CQQPECASWQAGP---------WGQCSVTCG 1124
+WC+ ++ DP T C+ EC S + P W CS TC
Sbjct: 591 LWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSPCSRTCS 650
Query: 1125 QGYQLRAVKCIIGTYMSVVDDN--DCNAATRPTDTQDCELPSCHPPPAAPETR------- 1175
G R KC +D DCN + + CE P C P P R
Sbjct: 651 AGISSRERKC------PGLDSEARDCNGPRK--QYRICENPPC--PAGLPGFRDWQCQAY 700
Query: 1176 --RSTYSAPRTQWR--FGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPV-A 1230
R++ QW+ PC+ C + + + ++ V D ++C + A
Sbjct: 701 SVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSEK---VMDGTSCGYQGLDICA 757
Query: 1231 KEECSVTPC----GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPET 1286
C C G D C V G G++ + + +H + IP
Sbjct: 758 NGRCQKVGCDGLLGSLARED--HCGVCNGNGKSCKIIK--GDFNHTRGAGYVEVLVIPAG 813
Query: 1287 DQDCSMSPCPQRTPDSGLAQHPFQ----NEDYRPRSASPSRTHVLGGNQWRTGPWGACSS 1342
+ + ++ S LA N D++ + + R G W S+
Sbjct: 814 ARRIKV--VEEKPAHSYLALRDAGKQSINSDWKIEHSGAFNLAGTTVHYVRRGLWEKISA 871
Query: 1343 TCAGGSQRRVVVC--QDENGYTANDCVERIKPDEQRACESGPCP--QWAYGNWGECTKLC 1398
+ ++V QD+N + P + P P W + +W +C C
Sbjct: 872 KGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATC 931
Query: 1399 GGGIRTRLVVCQR---SNGERFPDLSCEILDKP-PDREQCNTHACPHDAAWSTGPWSSCS 1454
GGG R V C + N + C+ L KP P +CN C W W+ CS
Sbjct: 932 GGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC--QTRWMMTEWTPCS 989
Query: 1455 VSCGRGHKQRNVYC--MAKDGSHLESDYCKHLA-KPHGHRKCRGGRC-PKWKAGAWSQCS 1510
+CG+G + R V C +G+ + + + KP ++C G C W+AG WS+CS
Sbjct: 990 RTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECS 1049
Query: 1511 VSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQG-PRCPLYTWRAEEWQECTK 1569
V CG+G++ R V C K C TRP DC+ +C Y WR +W +C+
Sbjct: 1050 VKCGKGIRHRTVRCTNPRKK------CVLSTRPREAEDCEDYSKC--YVWRMGDWSKCSI 1101
Query: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
TCG+G + R + C+ HG C S++P C LQPC
Sbjct: 1102 TCGKGMQSRVIQCMHKITGR-HGNECFSSEKPAAYRPCHLQPC 1143
Score = 121 bits (304), Expect = 6e-27
Identities = 71/236 (30%), Positives = 100/236 (42%), Gaps = 25/236 (10%)
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHK---IARETECNPYTRPESE-RDCQGPRCPL 1556
W +W C +CG G ++ V C K I +C T+PE + R C C
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
Query: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV---HGARCDVSKRPVDRESCSLQPCE 1613
W EW C++TCG+G + R+V C N R + +P + C Q C
Sbjct: 979 -RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
Query: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP-GTQPPSVHPCYL 1672
VW G WSECSV CGKG + R V C+ C T+P C
Sbjct: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTN-------------PRKKCVLSTRPREAEDC-- 1082
Query: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN-EDQPSHLCHTDLKPEERKTC 1727
D WR+G+W CS++CG G+ R +QC+ + + C + KP + C
Sbjct: 1083 EDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPC 1138
Score = 115 bits (289), Expect = 3e-25
Identities = 74/259 (28%), Positives = 106/259 (40%), Gaps = 39/259 (15%)
Query: 1052 PCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDR----LNDRMCDPETKPT-SMQTCQQP 1106
P W W +C TCG G + V C + +++ C TKP ++ C +
Sbjct: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQ 974
Query: 1107 ECAS-WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCNAATRPTDTQDCEL 1162
C + W W CS TCG+G Q R V C + + + DC +P Q CE
Sbjct: 975 PCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDC-IGPKPASAQRCEG 1033
Query: 1163 PSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESAC 1222
C T W G W+ CS CGKG R R V C + C
Sbjct: 1034 QDC-----------------MTVWEAGVWSECSVKCGKGIRHRTVRCTN------PRKKC 1070
Query: 1223 ATLPRPVAKEEC-SVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDR--SECD 1279
RP E+C + C W+ DWS CS+TCG+G +R + C++ + R +EC
Sbjct: 1071 VLSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMH---KITGRHGNECF 1127
Query: 1280 QDYIPETDQDCSMSPCPQR 1298
P + C + PC ++
Sbjct: 1128 SSEKPAAYRPCHLQPCNEK 1146
Score = 113 bits (283), Expect = 2e-24
Identities = 61/183 (33%), Positives = 87/183 (47%), Gaps = 13/183 (7%)
Query: 1555 PLYTWRAEEWQECTKTCGEGSRYRKVVC---VDDNKNEVHGARCDVSKRPVDR-ESCSLQ 1610
PL+ W W++C TCG G R V C + N + V +C +P + C+ Q
Sbjct: 915 PLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQ 974
Query: 1611 PCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
PC+ W+ EW+ CS TCGKG + R V+C++ + N +C G +P S C
Sbjct: 975 PCQTRWMMTEWTPCSRTCGKGMQSRQVACTQQLS---NGTLIRARERDCIGPKPASAQRC 1031
Query: 1671 YLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNV 1730
+DC W G W CSV CG G+ R+V+C TN P C +P E + C +
Sbjct: 1032 EGQDC--MTVWEAGVWSECSVKCGKGIRHRTVRC-TN---PRKKCVLSTRPREAEDCEDY 1085
Query: 1731 YNC 1733
C
Sbjct: 1086 SKC 1088
Score = 38.9 bits (89), Expect = 0.049
Identities = 51/207 (24%), Positives = 77/207 (37%), Gaps = 49/207 (23%)
Query: 1146 NDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAP-RTQWRFGSWTPCSATCGKGTRM 1204
++C T P +PS P TY+A + Q FG P ++ C + M
Sbjct: 538 SNCLLQTNPQSVNSVMVPSKLPG--------MTYTADEQCQILFG---PLASFCQE---M 583
Query: 1205 RYVSCRDENGSVADESACAT-LPRPVAKEECSVTP-----------------CGQWKALD 1246
++V C V E C T L P+ +C + G+W
Sbjct: 584 QHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSL-- 641
Query: 1247 WSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQ 1306
WS CS TC G ++R+ C D + + Y + C PCP P
Sbjct: 642 WSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQY-----RICENPPCPAGLP----GF 692
Query: 1307 HPFQNEDYRPRSASPSRTHVLGGNQWR 1333
+Q + Y R++SP H+L QW+
Sbjct: 693 RDWQCQAYSVRTSSPK--HIL---QWQ 714
Score = 34.7 bits (78), Expect = 0.93
Identities = 29/106 (27%), Positives = 36/106 (33%), Gaps = 23/106 (21%)
Query: 1137 GTYMSVVDDNDCNAATRPT-DTQDCELPS------CHPPPAAPETRRSTYSAPRTQWRFG 1189
G + V + +C P D DC+L C +APE +S
Sbjct: 590 GLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSL-------- 641
Query: 1190 SWTPCSATCGKGTRMRYVSC-------RDENGSVADESACATLPRP 1228
W+PCS TC G R C RD NG C P P
Sbjct: 642 -WSPCSRTCSAGISSRERKCPGLDSEARDCNGPRKQYRICENPPCP 686
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 435 bits (1119), Expect = e-121
Identities = 321/1070 (30%), Positives = 480/1070 (44%), Gaps = 141/1070 (13%)
Query: 68 HFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVT 127
H + R ++ WP S ++ ++ FG++ L N + P +V
Sbjct: 82 HLRVARSPLHPGGTLWPGRVGRHS------LYFNVTVFGKELHLRLRPNRRLVVPGSSVE 135
Query: 128 LLGTPGVNQTKFYSEEEAEL------KHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDG 181
+ E+ EL + C Y G V IS C G+ G R+
Sbjct: 136 ------------WQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDST 183
Query: 182 DYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRA 241
D+FIEPL+ Q+++E + H++YRR A Q+E
Sbjct: 184 DFFIEPLER--GQQEKEASGRTHVVYRREAVQQE-------------------------- 215
Query: 242 RKWGERINLAGDV--AALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLV 299
W E GD+ A G G++ +T KR H + + +EVL+
Sbjct: 216 --WAEP---DGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYS-----IEVLL 265
Query: 300 VADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISF 358
V D+ +V +HG E++Q+Y+LTLM+IV IY D S+G INI +V LI++ Q I
Sbjct: 266 VVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIER 325
Query: 359 -NAQTTLKNFCQWQHSKNSPG---GIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDP 414
N +L+ C+W HS+ HHD V LTRQD + G A + +C P
Sbjct: 326 GNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPS-------GYAPVTGMCHP 378
Query: 415 YRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAPTLNFYTNPW 473
RSC+++ + G S+AF IAHE GHV M HD N C +E S VMAP + + +
Sbjct: 379 LRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADE--TSLGSVMAPLVQAAFHRF 436
Query: 474 MWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCP 533
WS+CS+ ++ +L + +CLL++P +P P +LPGI Y++++QC FG G Q C
Sbjct: 437 HWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCL 494
Query: 534 YMMQ---CRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPV-TDG 589
C++LWC++ + + C+T+ P DGTEC PGK C G C+ K + DG
Sbjct: 495 AFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDG 553
Query: 590 SWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDF 649
W SW+ FG+CSR+CGGG+++ R CN P P GG+ C+G +++ CN+E C DF
Sbjct: 554 GWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDF 613
Query: 650 RDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGT 709
R +QCA + + + N WVP Y +C+L C+ A + V DGT
Sbjct: 614 RAQQCAKRNSYYVHQNA---KHSWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGT 669
Query: 710 PCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN--TVHYGY 766
C +D +C +G C GCD + S DKCGVCGGDNS C+TV GT + G
Sbjct: 670 RCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGA 729
Query: 767 NTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAV 826
+V+IPAGA +I + + E + + G F+LN ++ +G
Sbjct: 730 LKLVQIPAGARHIQIE----ALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMG--- 782
Query: 827 VEYSGS-ETAVERINSTDRIEQELLLQVL---SVGKLYNPDVRY-----------SFNIP 871
+E+ + E A E + ++ + + + + L G + +Y S N+
Sbjct: 783 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 842
Query: 872 IEDKPQQFYWNSHGPWQACSKPCQGE-RKRKLVCTRESDQLTVSDQRCDRLPQPGHITEP 930
+E+ + W + W CSK C G + K C R D V CD +P I
Sbjct: 843 LEEM-DTYEW-ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRR 900
Query: 931 CGT-DCDLR-WHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPS 987
C C W CS CG LG +T I C L T KV + +P
Sbjct: 901 CNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQC--LLPLSNGTHKVMPAKACAGDRPE 958
Query: 988 NREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQR 1047
R C WR AW++CS +C G Q+R+ +C N + C T+Q
Sbjct: 959 ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEGDRPDTVQV 1015
Query: 1048 CSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKP 1097
CS L CG H++ V E + P+++P
Sbjct: 1016 CS---------------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEP 1050
Score = 108 bits (270), Expect = 5e-23
Identities = 62/175 (35%), Positives = 82/175 (46%), Gaps = 11/175 (6%)
Query: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNE-VHGARCDVSKRPVD-RESCSLQPCEY 1614
Y W + W C+K CG G ++ K C + V CD KRP R C+ PC
Sbjct: 849 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 908
Query: 1615 -VWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
VW+T EW CS +CGK G + R + C N + C G +P + PC
Sbjct: 909 PVWVTEEWGACSRSCGKLGVQTRGIQC---LLPLSNGTHKVMPAKACAGDRPEARRPCLR 965
Query: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
CP A WR+G W CS +CG G+ QR V C TN + H C D +P+ + C
Sbjct: 966 VPCP--AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH-CEGD-RPDTVQVC 1016
Score = 99.0 bits (245), Expect = 4e-20
Identities = 57/182 (31%), Positives = 83/182 (45%), Gaps = 16/182 (8%)
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGT-HKIARETECNPYTRPES-ERDCQGPRCPLY 1557
+W +W+ CS +CG G+Q GC+ H + + C+ RP+ R C C
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 1558 TWRAEEWQECTKTCGE-GSRYRKVVCVDDNKNEVHG---ARCDVSKRPVDRESCSLQPCE 1613
W EEW C+++CG+ G + R + C+ N H A+ RP R C PC
Sbjct: 910 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCP 969
Query: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
W G WS+CS TCG+G +QR V C + + +C G +P +V C L
Sbjct: 970 AQWRLGAWSQCSATCGEGIQQRQVVC----------RTNANSLGHCEGDRPDTVQVCSLP 1019
Query: 1674 DC 1675
C
Sbjct: 1020 AC 1021
Score = 97.8 bits (242), Expect = 9e-20
Identities = 62/177 (35%), Positives = 83/177 (46%), Gaps = 15/177 (8%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHL-ESDYCKHLAKPHG-HRKCRGGRC--PK 1500
W+ W+ CS +CG G + C + H+ + C H +P R+C C P
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 910
Query: 1501 WKAGAWSQCSVSCGR-GVQQRHVGCQI----GTHKIARETECNPYTRPESERDCQGPRCP 1555
W W CS SCG+ GVQ R + C + GTHK+ C RPE+ R C CP
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCP 969
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
WR W +C+ TCGEG + R+VVC N N + C+ RP + CSL C
Sbjct: 970 A-QWRLGAWSQCSATCGEGIQQRQVVC-RTNANSL--GHCE-GDRPDTVQVCSLPAC 1021
Score = 93.6 bits (231), Expect = 2e-18
Identities = 61/205 (29%), Positives = 89/205 (43%), Gaps = 18/205 (8%)
Query: 995 ECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQE--KVTIQRCSEF 1051
E +T W +W CSK+C GG Q + C R + ++ C H++ K +RC++
Sbjct: 845 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 904
Query: 1052 PC--PQWKSGDWSECLVTCGK-GHKHRQVWCQF----GEDRLNDRMCDPETKPTSMQTCQ 1104
PC P W + +W C +CGK G + R + C G ++ +P + + C
Sbjct: 905 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 964
Query: 1105 QPEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELP 1163
+ C A W+ G W QCS TCG+G Q R V C + D RP Q C LP
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD-----RPDTVQVCSLP 1019
Query: 1164 SCHPPPAAPETRRSTY--SAPRTQW 1186
+C R + P QW
Sbjct: 1020 ACGGNHQNSTVRADVWELGTPEGQW 1044
Score = 89.0 bits (219), Expect = 4e-17
Identities = 73/236 (30%), Positives = 98/236 (41%), Gaps = 20/236 (8%)
Query: 1260 TRQVMCVNYSDHVIDRSEC--DQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPR 1317
T M + + D V D E +PE ++ P + P S LA +ED P
Sbjct: 777 TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPT-EGGPRSSLAYKYVIHEDLLPL 835
Query: 1318 SASPS-RTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIKPD 1373
S + + +W W CS C GG Q C+ D + + C + +P
Sbjct: 836 IGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPK 895
Query: 1374 E-QRACESGPC--PQWAYGNWGECTKLCGG-GIRTRLVVC--QRSNGER--FPDLSCEIL 1425
+R C PC P W WG C++ CG G++TR + C SNG P +C
Sbjct: 896 PIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG- 954
Query: 1426 DKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGS--HLESD 1479
D+P R C CP A W G WS CS +CG G +QR V C S H E D
Sbjct: 955 DRPEARRPCLRVPCP--AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD 1008
Score = 87.4 bits (215), Expect = 1e-16
Identities = 59/196 (30%), Positives = 87/196 (44%), Gaps = 33/196 (16%)
Query: 1055 QWKSGDWSECLVTCGKGHKHRQVWCQFGEDR--LNDRMCDPETKPTSMQT-CQQPECAS- 1110
+W W+ C CG G + + C+ D + +CD + +P ++ C Q C+
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 1111 -WQAGPWGQCSVTCGQ-GYQLRAVKCII----GTYMSVVDDNDCNAATRPTDTQDCELPS 1164
W WG CS +CG+ G Q R ++C++ GT+ V+ C A RP + C
Sbjct: 910 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTH-KVMPAKAC-AGDRPEARRPCLRVP 967
Query: 1165 CHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACAT 1224
C PA QWR G+W+ CSATCG+G + R V CR S+
Sbjct: 968 C---PA--------------QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG--- 1007
Query: 1225 LPRPVAKEECSVTPCG 1240
RP + CS+ CG
Sbjct: 1008 -DRPDTVQVCSLPACG 1022
Score = 86.3 bits (212), Expect = 3e-16
Identities = 60/208 (28%), Positives = 80/208 (38%), Gaps = 45/208 (21%)
Query: 1185 QWRFGSWTPCSATCGKGTRMRYVSCRDENGS-VADESACATLPRPVA-KEECSVTPCGQ- 1241
+W SW PCS CG G + CR + C RP + C+ PC Q
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 1242 -WKALDWSSCSVTCGQ-GRATRQVMCV----NYSDHVIDRSECDQDYIPETDQDCSMSPC 1295
W +W +CS +CG+ G TR + C+ N + V+ C D PE + C PC
Sbjct: 910 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDR-PEARRPCLRVPC 968
Query: 1296 PQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVC 1355
P QWR G W CS+TC G Q+R VVC
Sbjct: 969 PA---------------------------------QWRLGAWSQCSATCGEGIQQRQVVC 995
Query: 1356 QDENGYTANDCVERIKPDEQRACESGPC 1383
+ N + C E +PD + C C
Sbjct: 996 R-TNANSLGHC-EGDRPDTVQVCSLPAC 1021
Score = 80.1 bits (196), Expect = 2e-14
Identities = 60/199 (30%), Positives = 81/199 (40%), Gaps = 28/199 (14%)
Query: 1104 QQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQD-CEL 1162
++ + W W CS CG G Q C +V + C+ RP + C
Sbjct: 844 EEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQ 903
Query: 1163 PSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRD--ENGS--VA 1217
C P W W CS +CGK G + R + C NG+ V
Sbjct: 904 HPCSQPV----------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVM 947
Query: 1218 DESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRS 1276
ACA RP A+ C PC QW+ WS CS TCG+G RQV+C ++ +
Sbjct: 948 PAKACAG-DRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---G 1003
Query: 1277 ECDQDYIPETDQDCSMSPC 1295
C+ D P+T Q CS+ C
Sbjct: 1004 HCEGDR-PDTVQVCSLPAC 1021
Score = 34.3 bits (77), Expect = 1.2
Identities = 30/108 (27%), Positives = 42/108 (38%), Gaps = 19/108 (17%)
Query: 1623 ECSVTCGKGYKQRLV-----SCSEIYTGKENYEYSYQTTINCP--GTQPPSVHPCYLRDC 1675
+C G GY+ L C +++ + Y +T P GT+ C+ C
Sbjct: 481 QCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC 540
Query: 1676 ----PVSATWRVGNW------GSCSVSCGVGVMQRSVQCLTNEDQPSH 1713
P + G W GSCS SCG GV RS C N P++
Sbjct: 541 IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSC--NNPSPAY 586
Score = 32.7 bits (73), Expect = 3.5
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 1371 KPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPD 1430
K EQ + G W +G C++ CGGG+R+R C + + C L +
Sbjct: 543 KSPEQTYGQDGGWSSWT--KFGSCSRSCGGGVRSRSRSCNNPS-PAYGGRLC--LGPMFE 597
Query: 1431 REQCNTHACP 1440
+ CN+ CP
Sbjct: 598 YQVCNSEECP 607
Score = 32.3 bits (72), Expect = 4.6
Identities = 36/145 (24%), Positives = 50/145 (34%), Gaps = 40/145 (27%)
Query: 1461 HKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKA--------GAWSQ---- 1508
H +C K G L+ C + C G C WK+ G WS
Sbjct: 509 HPDNPYFCKTKKGPPLDGTECAP------GKWCFKGHCI-WKSPEQTYGQDGGWSSWTKF 561
Query: 1509 --CSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQE 1566
CS SCG GV+ +R CN + R C G P++ ++ +E
Sbjct: 562 GSCSRSCGGGVR-------------SRSRSCNNPSPAYGGRLCLG---PMFEYQVCNSEE 605
Query: 1567 CTKTCGEGSRYRKVVCVDDNKNEVH 1591
C T + +R C N VH
Sbjct: 606 CPGTYED---FRAQQCAKRNSYYVH 627
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 435 bits (1119), Expect = e-121
Identities = 321/1070 (30%), Positives = 479/1070 (44%), Gaps = 138/1070 (12%)
Query: 68 HFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVT 127
H + R ++ WP S ++ ++ FG++ L N + P +V
Sbjct: 82 HLRVARSPLHPGGTLWPGRVGRHS------LYFNVTVFGKELHLRLRPNRRLVVPGSSVE 135
Query: 128 LLGTPGVNQTKFYSEEEAEL------KHCFYKGYVNTNSEHTAVISLCSGMLGTFRSHDG 181
+ E+ EL + C Y G V IS C G+ G R+
Sbjct: 136 ------------WQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDST 183
Query: 182 DYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRHACDTSEHKNRHSKDKKKTRA 241
D+FIEPL+ Q+++E + H++YRR A Q+E
Sbjct: 184 DFFIEPLER--GQQEKEASGRTHVVYRREAVQQE-------------------------- 215
Query: 242 RKWGERINLAGDV--AALNSGLATEAFSAYGNKTDNTREKRTHRRTKRFLSYPRFVEVLV 299
W E GD+ A G G++ +T KR H + + +EVL+
Sbjct: 216 --WAEP---DGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYS-----IEVLL 265
Query: 300 VADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLINIVIVNLIVIHNEQDGPSISF 358
V D+ +V +HG E++Q+Y+LTLM+IV IY D S+G INI +V LI++ Q I
Sbjct: 266 VVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIER 325
Query: 359 -NAQTTLKNFCQWQHSKNSPG---GIHHDTAVLLTRQDICRAHDKCDTLGLAELGTICDP 414
N +L+ C+W HS+ HHD V LTRQD G A + +C P
Sbjct: 326 GNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF----GPSGMQGYAPVTGMCHP 381
Query: 415 YRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEGVKSPQHVMAPTLNFYTNPW 473
RSC+++ + G S+AF IAHE GHV M HD N C +E S VMAP + + +
Sbjct: 382 LRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADE--TSLGSVMAPLVQAAFHRF 439
Query: 474 MWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGILYNVNKQCELIFGPGSQVCP 533
WS+CS+ ++ +L + +CLL++P +P P +LPGI Y++++QC FG G Q C
Sbjct: 440 HWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYSMDEQCRFDFGSGYQTCL 497
Query: 534 YMMQ---CRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKHCKYGFCVPKEMDVPV-TDG 589
C++LWC++ + + C+T+ P DGTEC PGK C G C+ K + DG
Sbjct: 498 AFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDG 556
Query: 590 SWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDF 649
W SW+ FG+CSR+CGGG+++ R CN P P GG+ C+G +++ CN+E C DF
Sbjct: 557 GWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDF 616
Query: 650 RDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGT 709
R +QCA + + + N WVP Y +C+L C+ A + V DGT
Sbjct: 617 RAQQCAKRNSYYVHQNA---KHSWVP-YEPDDDAQKCELICQSADTGDVVFMNQVVHDGT 672
Query: 710 PCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN--TVHYGY 766
C +D +C +G C GCD + S DKCGVCGGDNS C+TV GT + G
Sbjct: 673 RCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGA 732
Query: 767 NTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAV 826
+V+IPAGA +I + + E + + G F+LN ++ +G
Sbjct: 733 LKLVQIPAGARHIQIE----ALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMG--- 785
Query: 827 VEYSGS-ETAVERINSTDRIEQELLLQVL---SVGKLYNPDVRY-----------SFNIP 871
+E+ + E A E + ++ + + + + L G + +Y S N+
Sbjct: 786 LEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVL 845
Query: 872 IEDKPQQFYWNSHGPWQACSKPCQGE-RKRKLVCTRESDQLTVSDQRCDRLPQPGHITEP 930
+E+ + W + W CSK C G + K C R D V CD +P I
Sbjct: 846 LEEM-DTYEW-ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRR 903
Query: 931 CGT-DCDLR-WHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPS 987
C C W CS CG LG +T I C L T KV + +P
Sbjct: 904 CNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQC--LLPLSNGTHKVMPAKACAGDRPE 961
Query: 988 NREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQR 1047
R C WR AW++CS +C G Q+R+ +C N + C T+Q
Sbjct: 962 ARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEGDRPDTVQV 1018
Query: 1048 CSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKP 1097
CS L CG H++ V E + P+++P
Sbjct: 1019 CS---------------LPACGGNHQNSTVRADVWELGTPEGQWVPQSEP 1053
Score = 108 bits (270), Expect = 5e-23
Identities = 62/175 (35%), Positives = 82/175 (46%), Gaps = 11/175 (6%)
Query: 1557 YTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNE-VHGARCDVSKRPVD-RESCSLQPCEY 1614
Y W + W C+K CG G ++ K C + V CD KRP R C+ PC
Sbjct: 852 YEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQ 911
Query: 1615 -VWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
VW+T EW CS +CGK G + R + C N + C G +P + PC
Sbjct: 912 PVWVTEEWGACSRSCGKLGVQTRGIQC---LLPLSNGTHKVMPAKACAGDRPEARRPCLR 968
Query: 1673 RDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
CP A WR+G W CS +CG G+ QR V C TN + H C D +P+ + C
Sbjct: 969 VPCP--AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH-CEGD-RPDTVQVC 1019
Score = 99.0 bits (245), Expect = 4e-20
Identities = 57/182 (31%), Positives = 83/182 (45%), Gaps = 16/182 (8%)
Query: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGT-HKIARETECNPYTRPES-ERDCQGPRCPLY 1557
+W +W+ CS +CG G+Q GC+ H + + C+ RP+ R C C
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 1558 TWRAEEWQECTKTCGE-GSRYRKVVCVDDNKNEVHG---ARCDVSKRPVDRESCSLQPCE 1613
W EEW C+++CG+ G + R + C+ N H A+ RP R C PC
Sbjct: 913 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCP 972
Query: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLR 1673
W G WS+CS TCG+G +QR V C + + +C G +P +V C L
Sbjct: 973 AQWRLGAWSQCSATCGEGIQQRQVVC----------RTNANSLGHCEGDRPDTVQVCSLP 1022
Query: 1674 DC 1675
C
Sbjct: 1023 AC 1024
Score = 97.8 bits (242), Expect = 9e-20
Identities = 62/177 (35%), Positives = 83/177 (46%), Gaps = 15/177 (8%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHL-ESDYCKHLAKPHG-HRKCRGGRC--PK 1500
W+ W+ CS +CG G + C + H+ + C H +P R+C C P
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
Query: 1501 WKAGAWSQCSVSCGR-GVQQRHVGCQI----GTHKIARETECNPYTRPESERDCQGPRCP 1555
W W CS SCG+ GVQ R + C + GTHK+ C RPE+ R C CP
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCP 972
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
WR W +C+ TCGEG + R+VVC N N + C+ RP + CSL C
Sbjct: 973 A-QWRLGAWSQCSATCGEGIQQRQVVC-RTNANSL--GHCE-GDRPDTVQVCSLPAC 1024
Score = 93.6 bits (231), Expect = 2e-18
Identities = 61/205 (29%), Positives = 89/205 (43%), Gaps = 18/205 (8%)
Query: 995 ECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTHQE--KVTIQRCSEF 1051
E +T W +W CSK+C GG Q + C R + ++ C H++ K +RC++
Sbjct: 848 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
Query: 1052 PC--PQWKSGDWSECLVTCGK-GHKHRQVWCQF----GEDRLNDRMCDPETKPTSMQTCQ 1104
PC P W + +W C +CGK G + R + C G ++ +P + + C
Sbjct: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
Query: 1105 QPEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELP 1163
+ C A W+ G W QCS TCG+G Q R V C + D RP Q C LP
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD-----RPDTVQVCSLP 1022
Query: 1164 SCHPPPAAPETRRSTY--SAPRTQW 1186
+C R + P QW
Sbjct: 1023 ACGGNHQNSTVRADVWELGTPEGQW 1047
Score = 89.0 bits (219), Expect = 4e-17
Identities = 73/236 (30%), Positives = 98/236 (41%), Gaps = 20/236 (8%)
Query: 1260 TRQVMCVNYSDHVIDRSEC--DQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPR 1317
T M + + D V D E +PE ++ P + P S LA +ED P
Sbjct: 780 TFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPT-EGGPRSSLAYKYVIHEDLLPL 838
Query: 1318 SASPS-RTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIKPD 1373
S + + +W W CS C GG Q C+ D + + C + +P
Sbjct: 839 IGSNNVLLEEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPK 898
Query: 1374 E-QRACESGPC--PQWAYGNWGECTKLCGG-GIRTRLVVC--QRSNGER--FPDLSCEIL 1425
+R C PC P W WG C++ CG G++TR + C SNG P +C
Sbjct: 899 PIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG- 957
Query: 1426 DKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGS--HLESD 1479
D+P R C CP A W G WS CS +CG G +QR V C S H E D
Sbjct: 958 DRPEARRPCLRVPCP--AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGD 1011
Score = 87.4 bits (215), Expect = 1e-16
Identities = 59/196 (30%), Positives = 87/196 (44%), Gaps = 33/196 (16%)
Query: 1055 QWKSGDWSECLVTCGKGHKHRQVWCQFGEDR--LNDRMCDPETKPTSMQT-CQQPECAS- 1110
+W W+ C CG G + + C+ D + +CD + +P ++ C Q C+
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 1111 -WQAGPWGQCSVTCGQ-GYQLRAVKCII----GTYMSVVDDNDCNAATRPTDTQDCELPS 1164
W WG CS +CG+ G Q R ++C++ GT+ V+ C A RP + C
Sbjct: 913 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTH-KVMPAKAC-AGDRPEARRPCLRVP 970
Query: 1165 CHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACAT 1224
C PA QWR G+W+ CSATCG+G + R V CR S+
Sbjct: 971 C---PA--------------QWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEG--- 1010
Query: 1225 LPRPVAKEECSVTPCG 1240
RP + CS+ CG
Sbjct: 1011 -DRPDTVQVCSLPACG 1025
Score = 86.3 bits (212), Expect = 3e-16
Identities = 60/208 (28%), Positives = 80/208 (38%), Gaps = 45/208 (21%)
Query: 1185 QWRFGSWTPCSATCGKGTRMRYVSCRDENGS-VADESACATLPRPVA-KEECSVTPCGQ- 1241
+W SW PCS CG G + CR + C RP + C+ PC Q
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 1242 -WKALDWSSCSVTCGQ-GRATRQVMCV----NYSDHVIDRSECDQDYIPETDQDCSMSPC 1295
W +W +CS +CG+ G TR + C+ N + V+ C D PE + C PC
Sbjct: 913 VWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDR-PEARRPCLRVPC 971
Query: 1296 PQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVC 1355
P QWR G W CS+TC G Q+R VVC
Sbjct: 972 PA---------------------------------QWRLGAWSQCSATCGEGIQQRQVVC 998
Query: 1356 QDENGYTANDCVERIKPDEQRACESGPC 1383
+ N + C E +PD + C C
Sbjct: 999 R-TNANSLGHC-EGDRPDTVQVCSLPAC 1024
Score = 80.1 bits (196), Expect = 2e-14
Identities = 60/199 (30%), Positives = 81/199 (40%), Gaps = 28/199 (14%)
Query: 1104 QQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQD-CEL 1162
++ + W W CS CG G Q C +V + C+ RP + C
Sbjct: 847 EEMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQ 906
Query: 1163 PSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRD--ENGS--VA 1217
C P W W CS +CGK G + R + C NG+ V
Sbjct: 907 HPCSQPV----------------WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVM 950
Query: 1218 DESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRS 1276
ACA RP A+ C PC QW+ WS CS TCG+G RQV+C ++ +
Sbjct: 951 PAKACAG-DRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL---G 1006
Query: 1277 ECDQDYIPETDQDCSMSPC 1295
C+ D P+T Q CS+ C
Sbjct: 1007 HCEGDR-PDTVQVCSLPAC 1024
Score = 34.3 bits (77), Expect = 1.2
Identities = 30/108 (27%), Positives = 42/108 (38%), Gaps = 19/108 (17%)
Query: 1623 ECSVTCGKGYKQRLV-----SCSEIYTGKENYEYSYQTTINCP--GTQPPSVHPCYLRDC 1675
+C G GY+ L C +++ + Y +T P GT+ C+ C
Sbjct: 484 QCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC 543
Query: 1676 ----PVSATWRVGNW------GSCSVSCGVGVMQRSVQCLTNEDQPSH 1713
P + G W GSCS SCG GV RS C N P++
Sbjct: 544 IWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSC--NNPSPAY 589
Score = 32.7 bits (73), Expect = 3.5
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 1371 KPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPD 1430
K EQ + G W +G C++ CGGG+R+R C + + C L +
Sbjct: 546 KSPEQTYGQDGGWSSWT--KFGSCSRSCGGGVRSRSRSCNNPS-PAYGGRLC--LGPMFE 600
Query: 1431 REQCNTHACP 1440
+ CN+ CP
Sbjct: 601 YQVCNSEECP 610
Score = 32.3 bits (72), Expect = 4.6
Identities = 36/145 (24%), Positives = 50/145 (34%), Gaps = 40/145 (27%)
Query: 1461 HKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKA--------GAWSQ---- 1508
H +C K G L+ C + C G C WK+ G WS
Sbjct: 512 HPDNPYFCKTKKGPPLDGTECAP------GKWCFKGHCI-WKSPEQTYGQDGGWSSWTKF 564
Query: 1509 --CSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQE 1566
CS SCG GV+ +R CN + R C G P++ ++ +E
Sbjct: 565 GSCSRSCGGGVR-------------SRSRSCNNPSPAYGGRLCLG---PMFEYQVCNSEE 608
Query: 1567 CTKTCGEGSRYRKVVCVDDNKNEVH 1591
C T + +R C N VH
Sbjct: 609 CPGTYED---FRAQQCAKRNSYYVH 630
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 389 bits (999), Expect = e-107
Identities = 309/1134 (27%), Positives = 461/1134 (40%), Gaps = 137/1134 (12%)
Query: 279 KRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLIN 338
+R +R +R +E+LV + H E+ + Y+LT ++I A + +DPS+G
Sbjct: 66 QRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFR 125
Query: 339 IVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKN-----SPGGIHHDTAVLLTRQDI 393
+ +V ++++ + P+I+ N ++L + C W + N PG H D + +TR D+
Sbjct: 126 VHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPG--HADLVLYITRFDL 183
Query: 394 CRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEE 453
G+ +LG C P SC I+ED+G TIAHE+GH F + HD
Sbjct: 184 ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDG---APGS 240
Query: 454 GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRP----YPLPVQ 509
G HVMA WS CSR+ + L G C+ + P +P +P Q
Sbjct: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 300
Query: 510 LPGILYNVNKQCELIFGPGSQVCPYMMQ----CRRLWCNNVNGVHKGCRTQHTPWADGTE 565
PG+ Y+ N+QC + FGP + C + + C+ L C+ C P DGTE
Sbjct: 301 -PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTE 359
Query: 566 CEPGKHCKYGFC--VPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNG 623
C K C G C + + + G W SW P CSR+CGGG+ T R+CN P P G
Sbjct: 360 CGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 419
Query: 624 GKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSG 679
G+ CVG ++ + CNT+ C K + +F +QCA DG+ + G W VP G
Sbjct: 420 GRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG 479
Query: 680 ILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTNDICVQGLCRQAGCDHVL 733
+ C+ CR G + + D +DGT C T +CV G CR GCD +
Sbjct: 480 DAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRM 536
Query: 734 NSKARRDKCGVCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQH----SFSG 788
+S+ D+C VCGGDNS+C G+F Y T + + T++ + H +
Sbjct: 537 DSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLA 596
Query: 789 ETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQE 848
Y+ G+ ++ N + R+ V +E I ++++
Sbjct: 597 VRIGGRYVV----AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQED 652
Query: 849 LLLQVL-----SVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQ-----GER 898
+QV G L PD+ +++ + KP+Q + W A PC G R
Sbjct: 653 ADIQVYRRYGEEYGNLTRPDITFTY---FQPKPRQAW-----VWAAVRGPCSVSCGAGLR 704
Query: 899 KRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRT 957
C ++ + V +C QP E C + C W V CSA CG G R
Sbjct: 705 WVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRE 764
Query: 958 LDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGT 1017
+ C + KT + E C+ + W S + C+ + G
Sbjct: 765 RPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGL 824
Query: 1018 QRRRAICV----NTRNDVLDDSKCTHQEKVTIQRCSEFPCPQ-WKSGD------------ 1060
CV V + ++ + C CP W D
Sbjct: 825 ALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPW 884
Query: 1061 ------------WS----ECLVTCGKGHKHRQVWCQFGEDR--LNDRMCDPETKPTS-MQ 1101
W+ C V+CG+G + C R + + +C +KP S +
Sbjct: 885 GSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRRE 944
Query: 1102 TCQQPEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIG----TYMSVVDDNDCNAATRPTD 1156
CQ C A WQ CSV+CG+G R + C ++ D C RP
Sbjct: 945 VCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP 1003
Query: 1157 TQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--RDENG 1214
+ C L C P +W+ S PCSA+CG GT R V+C D+
Sbjct: 1004 QEACSLEPCPP-----------------RWKVMSLGPCSASCGLGTARRSVACVQLDQGQ 1046
Query: 1215 SV-ADESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCVN-YSDH 1271
V DE+ACA L RP A C + C +W W CSV+CG G R+ C+ +
Sbjct: 1047 DVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA 1106
Query: 1272 VIDRSECDQDYIPETDQDCSMSPC-PQRTPDSGLAQHPFQNEDYRPRSASPSRT 1324
+ C P T + C PC Q TP L H +A+P RT
Sbjct: 1107 PVPADFCQHLPKPVTVRGCWAGPCVGQGTP--SLVPH--------EEAAAPGRT 1150
Score = 162 bits (409), Expect = 4e-39
Identities = 147/509 (28%), Positives = 206/509 (40%), Gaps = 64/509 (12%)
Query: 1076 QVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPW----GQCSVTCGQGYQLRA 1131
QV+ ++GE+ N T+P T QP+ QA W G CSV+CG G +
Sbjct: 656 QVYRRYGEEYGN------LTRPDITFTYFQPKPR--QAWVWAAVRGPCSVSCGAGLRWVN 707
Query: 1132 VKCIIGTYMSVVDDNDCNAATRPTDTQD-CELPSCHPPPAAPETRRSTYSAPRTQWRFGS 1190
C+ +V+ C + +P + C L C P W G
Sbjct: 708 YSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-----------------YWAVGD 750
Query: 1191 WTPCSATCGKGTRMRYVSCRDENGSVADE---SAC-ATLPRP-VAKEECSVTPC-GQWKA 1244
+ PCSA+CG G R R V C + GS+ + C A +P VA E C+ PC +W+
Sbjct: 751 FGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEV 810
Query: 1245 LDWSSCSVTCGQGRATRQVMCVNYSDHV---IDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
+ SSC+ G G A CV +D + + D + C CP P
Sbjct: 811 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP---PG 867
Query: 1302 SGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDEN-- 1359
G E P RT + W T G+CS +C G +C D
Sbjct: 868 WGHLDATSAGEK-APSPWGSIRTGAQAAHVW-TPAAGSCSVSCGRGLMELRFLCMDSALR 925
Query: 1360 -GYTANDCVERIKPDEQR-ACESGPCP-QWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
C KP +R C++ PCP +W Y C+ CG G+ R++ C R++GE
Sbjct: 926 VPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGED 984
Query: 1417 -----FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAK 1471
D C+ L +P +E C+ CP W CS SCG G +R+V C+
Sbjct: 985 DGEEILLDTQCQGLPRPEPQEACSLEPCP--PRWKVMSLGPCSASCGLGTARRSVACVQL 1042
Query: 1472 D-GSHLESDY--CKHLAKPHGHRKCRGGRCP-KWKAGAWSQCSVSCGRGVQQRHVGCQIG 1527
D G +E D C L +P C C +W G W +CSVSCG G+Q+R C +G
Sbjct: 1043 DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC-LG 1101
Query: 1528 THKIARETE--CNPYTRPESERDCQGPRC 1554
A C +P + R C C
Sbjct: 1102 PQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 156 bits (394), Expect = 2e-37
Identities = 128/450 (28%), Positives = 180/450 (40%), Gaps = 77/450 (17%)
Query: 1338 GACSSTCAGGSQRRVVVCQDENGYTANDCVERIK-------PDEQRACESGPCPQ-WAYG 1389
G CS +C G + C D+ + VE ++ P AC PCP WA G
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQ---ARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG 749
Query: 1390 NWGECTKLCGGGIRTRLVVCQRSNG---ERFPDLSCEILDKPPD--REQCNTHACPHDAA 1444
++G C+ CGGG+R R V C + G + P C + P E CN CP A
Sbjct: 750 DFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP--AR 807
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCM-AKDG------------------------------ 1473
W SSC+ + G G N C+ DG
Sbjct: 808 WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG 867
Query: 1474 -SHLESDYCKHLA-KPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKI 1531
HL++ A P G + W A S CSVSCGRG+ + C ++
Sbjct: 868 WGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRV 926
Query: 1532 ARETE-CNPYTRPESERD-CQGPRCPLYTWRAEEWQ----ECTKTCGEGSRYRKVVCV-- 1583
+ E C ++P S R+ CQ CP WQ C+ +CG G R + C
Sbjct: 927 PVQEELCGLASKPGSRREVCQAVPCPA------RWQYKLAACSVSCGRGVVRRILYCARA 980
Query: 1584 ---DDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCS 1640
DD + + +C RP +E+CSL+PC W CS +CG G +R V+C
Sbjct: 981 HGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACV 1040
Query: 1641 EIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQR 1700
++ G+ + +P + PC + DC + W VG W CSVSCG G+ +R
Sbjct: 1041 QLDQGQ---DVEVDEAACAALVRPEASVPCLIADC--TYRWHVGTWMECSVSCGDGIQRR 1095
Query: 1701 SVQCLTNEDQ---PSHLCHTDLKPEERKTC 1727
CL + Q P+ C KP + C
Sbjct: 1096 RDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1125
Score = 93.2 bits (230), Expect = 2e-18
Identities = 75/271 (27%), Positives = 102/271 (37%), Gaps = 29/271 (10%)
Query: 939 WHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP-SNREKCSGECN 997
W A+ S CS CG G L C V + C KP S RE C
Sbjct: 897 WTPAAGS-CSVSCGRGLMELRFLCMD----SALRVPVQEELCGLASKPGSRREVCQAVPC 951
Query: 998 TGGWRYSAWTECSKSCDGGTQRRRAICVNTRND-----VLDDSKCTHQEKVTIQR-CSEF 1051
W+Y CS SC G RR C + +L D++C + Q CS
Sbjct: 952 PARWQYKL-AACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 1010
Query: 1052 PCP-QWKSGDWSECLVTCGKGHKHRQVWC---QFGED-RLNDRMCDPETKPTSMQTCQQP 1106
PCP +WK C +CG G R V C G+D +++ C +P + C
Sbjct: 1011 PCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIA 1070
Query: 1107 ECA-SWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
+C W G W +CSV+CG G Q R C+ + V + C +P + C C
Sbjct: 1071 DCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Query: 1166 ----------HPPPAAPETRRSTYSAPRTQW 1186
H AAP +T + +W
Sbjct: 1131 VGQGTPSLVPHEEAAAPGRTTATPAGASLEW 1161
Score = 72.4 bits (176), Expect = 4e-12
Identities = 72/259 (27%), Positives = 101/259 (38%), Gaps = 41/259 (15%)
Query: 1509 CSVSCGRGVQQRHVGCQIGTHKIARET-ECNPYTRPESERD-CQGPRCPLYTWRAEEWQE 1566
CSVSCG G++ + C K ET +C +P + + C CP Y W ++
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPY-WAVGDFGP 753
Query: 1567 CTKTCGEGSRYRKVVCVDDNKN---EVHGARC--DVSKRPVDRESCSLQPCEYVWITGEW 1621
C+ +CG G R R V CV+ + + ARC + V E+C+ QPC W E
Sbjct: 754 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 813
Query: 1622 SECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCP----- 1676
S C+ G G +C G + E + P+ PC CP
Sbjct: 814 SSCTSAGGAGLALENETC---VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 870
Query: 1677 ---------VSATW---RVGN-----W----GSCSVSCGVGVMQRSVQCLTNE---DQPS 1712
+ W R G W GSCSVSCG G+M+ C+ +
Sbjct: 871 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 930
Query: 1713 HLCHTDLKP-EERKTCRNV 1730
LC KP R+ C+ V
Sbjct: 931 ELCGLASKPGSRREVCQAV 949
Score = 32.0 bits (71), Expect = 6.0
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 6/55 (10%)
Query: 1388 YGNWGE---CTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
+ +WG C++ CGGG+ TR C F +C D E CNT AC
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPR-PAFGGRACVGADL--QAEMCNTQAC 438
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 388 bits (997), Expect = e-107
Identities = 300/1104 (27%), Positives = 450/1104 (40%), Gaps = 126/1104 (11%)
Query: 279 KRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLIN 338
+R +R +R +E+LV + H E+ + Y+LT ++I A + +DPS+G
Sbjct: 66 QRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFR 125
Query: 339 IVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKN-----SPGGIHHDTAVLLTRQDI 393
+ +V ++++ + P+I+ N ++L + C W + N PG H D + +TR D+
Sbjct: 126 VHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPG--HADLVLYITRFDL 183
Query: 394 CRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEE 453
G+ +LG C P SC I+ED+G TIAHE+GH F + HD
Sbjct: 184 ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDG---APGS 240
Query: 454 GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRP----YPLPVQ 509
G HVMA WS CSR+ + L G C+ + P +P +P Q
Sbjct: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ 300
Query: 510 LPGILYNVNKQCELIFGPGSQVCPYMMQ----CRRLWCNNVNGVHKGCRTQHTPWADGTE 565
PG+ Y+ N+QC + FGP + C + + C+ L C+ C P DGTE
Sbjct: 301 -PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTE 359
Query: 566 CEPGKHCKYGFC--VPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNG 623
C K C G C + + + G W SW P CSR+CGGG+ T R+CN P P G
Sbjct: 360 CGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 419
Query: 624 GKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSG 679
G+ CVG ++ + CNT+ C K + +F +QCA DG+ + G W VP G
Sbjct: 420 GRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQG 479
Query: 680 ILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTNDICVQGLCRQAGCDHVL 733
+ C+ CR G + + D +DGT C T +CV G CR GCD +
Sbjct: 480 DAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRM 536
Query: 734 NSKARRDKCGVCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQH----SFSG 788
+S+ D+C VCGGDNS+C G+F Y T + + T++ + H +
Sbjct: 537 DSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLA 596
Query: 789 ETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQE 848
Y+ G+ ++ N + R+ V +E I ++++
Sbjct: 597 VRIGGRYVV----AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQED 652
Query: 849 LLLQVL-----SVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQ-----GER 898
+QV G L PD+ +++ + KP+Q + W A PC G R
Sbjct: 653 ADIQVYRRYGEEYGNLTRPDITFTY---FQPKPRQAW-----VWAAVRGPCSVSCGAGLR 704
Query: 899 KRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRT 957
C ++ + V +C QP E C + C W V CSA CG G R
Sbjct: 705 WVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRE 764
Query: 958 LDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGT 1017
+ C + KT + E C+ + W S + C+ + G
Sbjct: 765 RPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGL 824
Query: 1018 QRRRAICV----NTRNDVLDDSKCTHQEKVTIQRCSEFPCPQ-WKSGD------------ 1060
CV V + ++ + C CP W D
Sbjct: 825 ALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPW 884
Query: 1061 ------------WS----ECLVTCGKGHKHRQVWCQFGEDR--LNDRMCDPETKPTS-MQ 1101
W+ C V+CG+G + C R + + +C +KP S +
Sbjct: 885 GSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRRE 944
Query: 1102 TCQQPEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIG----TYMSVVDDNDCNAATRPTD 1156
CQ C A WQ CSV+CG+G R + C ++ D C RP
Sbjct: 945 VCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP 1003
Query: 1157 TQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--RDENG 1214
+ C L C P +W+ S PCSA+CG GT R V+C D+
Sbjct: 1004 QEACSLEPCPP-----------------RWKVMSLGPCSASCGLGTARRSVACVQLDQGQ 1046
Query: 1215 SV-ADESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCVN-YSDH 1271
V DE+ACA L RP A C + C +W W CSV+CG G R+ C+ +
Sbjct: 1047 DVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA 1106
Query: 1272 VIDRSECDQDYIPETDQDCSMSPC 1295
+ C P T + C PC
Sbjct: 1107 PVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 162 bits (409), Expect = 4e-39
Identities = 147/509 (28%), Positives = 206/509 (40%), Gaps = 64/509 (12%)
Query: 1076 QVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPW----GQCSVTCGQGYQLRA 1131
QV+ ++GE+ N T+P T QP+ QA W G CSV+CG G +
Sbjct: 656 QVYRRYGEEYGN------LTRPDITFTYFQPKPR--QAWVWAAVRGPCSVSCGAGLRWVN 707
Query: 1132 VKCIIGTYMSVVDDNDCNAATRPTDTQD-CELPSCHPPPAAPETRRSTYSAPRTQWRFGS 1190
C+ +V+ C + +P + C L C P W G
Sbjct: 708 YSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-----------------YWAVGD 750
Query: 1191 WTPCSATCGKGTRMRYVSCRDENGSVADE---SAC-ATLPRP-VAKEECSVTPC-GQWKA 1244
+ PCSA+CG G R R V C + GS+ + C A +P VA E C+ PC +W+
Sbjct: 751 FGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEV 810
Query: 1245 LDWSSCSVTCGQGRATRQVMCVNYSDHV---IDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
+ SSC+ G G A CV +D + + D + C CP P
Sbjct: 811 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP---PG 867
Query: 1302 SGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDEN-- 1359
G E P RT + W T G+CS +C G +C D
Sbjct: 868 WGHLDATSAGEK-APSPWGSIRTGAQAAHVW-TPAAGSCSVSCGRGLMELRFLCMDSALR 925
Query: 1360 -GYTANDCVERIKPDEQR-ACESGPCP-QWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
C KP +R C++ PCP +W Y C+ CG G+ R++ C R++GE
Sbjct: 926 VPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGED 984
Query: 1417 -----FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAK 1471
D C+ L +P +E C+ CP W CS SCG G +R+V C+
Sbjct: 985 DGEEILLDTQCQGLPRPEPQEACSLEPCP--PRWKVMSLGPCSASCGLGTARRSVACVQL 1042
Query: 1472 D-GSHLESDY--CKHLAKPHGHRKCRGGRCP-KWKAGAWSQCSVSCGRGVQQRHVGCQIG 1527
D G +E D C L +P C C +W G W +CSVSCG G+Q+R C +G
Sbjct: 1043 DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC-LG 1101
Query: 1528 THKIARETE--CNPYTRPESERDCQGPRC 1554
A C +P + R C C
Sbjct: 1102 PQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 156 bits (394), Expect = 2e-37
Identities = 128/450 (28%), Positives = 180/450 (40%), Gaps = 77/450 (17%)
Query: 1338 GACSSTCAGGSQRRVVVCQDENGYTANDCVERIK-------PDEQRACESGPCPQ-WAYG 1389
G CS +C G + C D+ + VE ++ P AC PCP WA G
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQ---ARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG 749
Query: 1390 NWGECTKLCGGGIRTRLVVCQRSNG---ERFPDLSCEILDKPPD--REQCNTHACPHDAA 1444
++G C+ CGGG+R R V C + G + P C + P E CN CP A
Sbjct: 750 DFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP--AR 807
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCM-AKDG------------------------------ 1473
W SSC+ + G G N C+ DG
Sbjct: 808 WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG 867
Query: 1474 -SHLESDYCKHLA-KPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKI 1531
HL++ A P G + W A S CSVSCGRG+ + C ++
Sbjct: 868 WGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRV 926
Query: 1532 ARETE-CNPYTRPESERD-CQGPRCPLYTWRAEEWQ----ECTKTCGEGSRYRKVVCV-- 1583
+ E C ++P S R+ CQ CP WQ C+ +CG G R + C
Sbjct: 927 PVQEELCGLASKPGSRREVCQAVPCPA------RWQYKLAACSVSCGRGVVRRILYCARA 980
Query: 1584 ---DDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCS 1640
DD + + +C RP +E+CSL+PC W CS +CG G +R V+C
Sbjct: 981 HGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACV 1040
Query: 1641 EIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQR 1700
++ G+ + +P + PC + DC + W VG W CSVSCG G+ +R
Sbjct: 1041 QLDQGQ---DVEVDEAACAALVRPEASVPCLIADC--TYRWHVGTWMECSVSCGDGIQRR 1095
Query: 1701 SVQCLTNEDQ---PSHLCHTDLKPEERKTC 1727
CL + Q P+ C KP + C
Sbjct: 1096 RDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1125
Score = 130 bits (327), Expect = 1e-29
Identities = 128/537 (23%), Positives = 194/537 (36%), Gaps = 95/537 (17%)
Query: 964 KYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWT-ECSKSCDGGTQRRRA 1022
+Y G + D F PKP W ++A CS SC G +
Sbjct: 660 RYGEEYGNLTRPDITFTYFQPKPRQ-----------AWVWAAVRGPCSVSCGAGLRWVNY 708
Query: 1023 ICVN-TRNDVLDDSKC--THQEKVTIQRCSEFPCPQ-WKSGDWSECLVTCGKGHKHRQVW 1078
C++ R ++++ +C + Q + C PCP W GD+ C +CG G + R V
Sbjct: 709 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVR 768
Query: 1079 CQFGEDRLNDRM------CDPETKPTSMQTCQQPEC-ASWQAGPWGQCSVTCGQGYQLRA 1131
C + L + + +++TC C A W+ C+ G G L
Sbjct: 769 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALEN 828
Query: 1132 VKCIIGT--YMSVVDDNDCNAATRPTDTQDCELPSCHP------PPAAPETRRSTYSAPR 1183
C+ G + V + + + + C SC P +A E S + + R
Sbjct: 829 ETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIR 888
Query: 1184 TQWRFGS-WTP----CSATCGKGTRMRYVSCRDENGSV-ADESACATLPRPVAKEE-CSV 1236
T + WTP CS +CG+G C D V E C +P ++ E C
Sbjct: 889 TGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQA 948
Query: 1237 TPCGQWKALDWSSCSVTCGQGRATRQVMCV-----NYSDHVIDRSECDQDYIPETDQDCS 1291
PC ++CSV+CG+G R + C + + ++ ++C PE + CS
Sbjct: 949 VPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACS 1008
Query: 1292 MSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRR 1351
+ PCP R W+ G CS++C G+ RR
Sbjct: 1009 LEPCPPR---------------------------------WKVMSLGPCSASCGLGTARR 1035
Query: 1352 VVVC-QDENGYTAN----DCVERIKPDEQRACESGPCP-QWAYGNWGECTKLCGGGIRTR 1405
V C Q + G C ++P+ C C +W G W EC+ CG GI+ R
Sbjct: 1036 SVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRR 1095
Query: 1406 LVVCQRSNGER-FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGH 1461
C + P C+ L KP C C A CGR H
Sbjct: 1096 RDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGA------------CGRQH 1140
Score = 72.4 bits (176), Expect = 4e-12
Identities = 72/259 (27%), Positives = 101/259 (38%), Gaps = 41/259 (15%)
Query: 1509 CSVSCGRGVQQRHVGCQIGTHKIARET-ECNPYTRPESERD-CQGPRCPLYTWRAEEWQE 1566
CSVSCG G++ + C K ET +C +P + + C CP Y W ++
Sbjct: 695 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPY-WAVGDFGP 753
Query: 1567 CTKTCGEGSRYRKVVCVDDNKN---EVHGARC--DVSKRPVDRESCSLQPCEYVWITGEW 1621
C+ +CG G R R V CV+ + + ARC + V E+C+ QPC W E
Sbjct: 754 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 813
Query: 1622 SECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCP----- 1676
S C+ G G +C G + E + P+ PC CP
Sbjct: 814 SSCTSAGGAGLALENETC---VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 870
Query: 1677 ---------VSATW---RVGN-----W----GSCSVSCGVGVMQRSVQCLTNE---DQPS 1712
+ W R G W GSCSVSCG G+M+ C+ +
Sbjct: 871 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 930
Query: 1713 HLCHTDLKP-EERKTCRNV 1730
LC KP R+ C+ V
Sbjct: 931 ELCGLASKPGSRREVCQAV 949
Score = 32.0 bits (71), Expect = 6.0
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 6/55 (10%)
Query: 1388 YGNWGE---CTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
+ +WG C++ CGGG+ TR C F +C D E CNT AC
Sbjct: 387 WSSWGPRSPCSRSCGGGVVTRRRQCNNPR-PAFGGRACVGADL--QAEMCNTQAC 438
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 362 bits (928), Expect = 3e-99
Identities = 291/1100 (26%), Positives = 436/1100 (39%), Gaps = 149/1100 (13%)
Query: 279 KRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSIGNLIN 338
+R +R +R +E+LV + H E+ + Y+LT ++I A + +DPS+G
Sbjct: 66 QRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFR 125
Query: 339 IVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKN-----SPGGIHHDTAVLLTRQDI 393
+ +V ++++ + P+I+ N ++L + C W + N PG H D + +TR D+
Sbjct: 126 VHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPG--HADLVLYITRFDL 183
Query: 394 CRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKCKEE 453
G+ +LG C P SC I+ED+G TIAHE+GH F + HD
Sbjct: 184 ELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDG---APGS 240
Query: 454 GVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGI 513
G HVMA WS CSR+ + L
Sbjct: 241 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLL-------------------------- 274
Query: 514 LYNVNKQCELIFGPGSQVCPYMMQ----CRRLWCNNVNGVHKGCRTQHTPWADGTECEPG 569
+ N+QC + FGP + C + + C+ L C+ C P DGTEC
Sbjct: 275 --SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVE 332
Query: 570 KHCKYGFC--VPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYC 627
K C G C + + + G W SW P CSR+CGGG+ T R+CN P P GG+ C
Sbjct: 333 KWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRAC 392
Query: 628 VGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNIN-GLLPNVRW---VPKYSGILMK 683
VG ++ + CNT+ C K + +F +QCA DG+ + G W VP G +
Sbjct: 393 VGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL- 451
Query: 684 DRCKLFCRVAGNTAYYQLRDRVIDGTPC------GQDTNDICVQGLCRQAGCDHVLNSKA 737
C+ CR G + + D +DGT C T +CV G CR GCD ++S+
Sbjct: 452 --CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ 509
Query: 738 RRDKCGVCGGDNSSCKTVAGTFNTVH-YGYNTVVRIPAGATNIDVRQH----SFSGETDD 792
D+C VCGGDNS+C G+F Y T + + T++ + H +
Sbjct: 510 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG 569
Query: 793 DNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQ 852
Y+ G+ ++ N + R+ V +E I ++++ +Q
Sbjct: 570 GRYVV----AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQ 625
Query: 853 VL-----SVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQ-----GERKRKL 902
V G L PD+ +++ + KP+Q + W A PC G R
Sbjct: 626 VYRRYGEEYGNLTRPDITFTY---FQPKPRQAW-----VWAAVRGPCSVSCGAGLRWVNY 677
Query: 903 VCTRESDQLTVSDQRCDRLPQPGHITEPCGTD-CDLRWHVASRSECSAQCGLGYRTLDIY 961
C ++ + V +C QP E C + C W V CSA CG G R +
Sbjct: 678 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVR 737
Query: 962 CAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRR 1021
C + KT + E C+ + W S + C+ + G
Sbjct: 738 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALEN 797
Query: 1022 AICV----NTRNDVLDDSKCTHQEKVTIQRCSEFPCPQ-WKSGD---------------- 1060
CV V + ++ + C CP W D
Sbjct: 798 ETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIR 857
Query: 1061 --------WS----ECLVTCGKGHKHRQVWCQFGEDR--LNDRMCDPETKPTS-MQTCQQ 1105
W+ C V+CG+G + C R + + +C +KP S + CQ
Sbjct: 858 TGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQA 917
Query: 1106 PEC-ASWQAGPWGQCSVTCGQGYQLRAVKCIIG----TYMSVVDDNDCNAATRPTDTQDC 1160
C A WQ CSV+CG+G R + C ++ D C RP + C
Sbjct: 918 VPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEAC 976
Query: 1161 ELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--RDENGSV-A 1217
L C P +W+ S PCSA+CG GT R V+C D+ V
Sbjct: 977 SLEPCPP-----------------RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEV 1019
Query: 1218 DESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCVN-YSDHVIDR 1275
DE+ACA L RP A C + C +W W CSV+CG G R+ C+ + +
Sbjct: 1020 DEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPA 1079
Query: 1276 SECDQDYIPETDQDCSMSPC 1295
C P T + C PC
Sbjct: 1080 DFCQHLPKPVTVRGCWAGPC 1099
Score = 162 bits (409), Expect = 4e-39
Identities = 147/509 (28%), Positives = 206/509 (40%), Gaps = 64/509 (12%)
Query: 1076 QVWCQFGEDRLNDRMCDPETKPTSMQTCQQPECASWQAGPW----GQCSVTCGQGYQLRA 1131
QV+ ++GE+ N T+P T QP+ QA W G CSV+CG G +
Sbjct: 625 QVYRRYGEEYGN------LTRPDITFTYFQPKPR--QAWVWAAVRGPCSVSCGAGLRWVN 676
Query: 1132 VKCIIGTYMSVVDDNDCNAATRPTDTQD-CELPSCHPPPAAPETRRSTYSAPRTQWRFGS 1190
C+ +V+ C + +P + C L C P W G
Sbjct: 677 YSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPP-----------------YWAVGD 719
Query: 1191 WTPCSATCGKGTRMRYVSCRDENGSVADE---SAC-ATLPRP-VAKEECSVTPC-GQWKA 1244
+ PCSA+CG G R R V C + GS+ + C A +P VA E C+ PC +W+
Sbjct: 720 FGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEV 779
Query: 1245 LDWSSCSVTCGQGRATRQVMCVNYSDHV---IDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
+ SSC+ G G A CV +D + + D + C CP P
Sbjct: 780 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCP---PG 836
Query: 1302 SGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDEN-- 1359
G E P RT + W T G+CS +C G +C D
Sbjct: 837 WGHLDATSAGEK-APSPWGSIRTGAQAAHVW-TPAAGSCSVSCGRGLMELRFLCMDSALR 894
Query: 1360 -GYTANDCVERIKPDEQR-ACESGPCP-QWAYGNWGECTKLCGGGIRTRLVVCQRSNGER 1416
C KP +R C++ PCP +W Y C+ CG G+ R++ C R++GE
Sbjct: 895 VPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLAACSVSCGRGVVRRILYCARAHGED 953
Query: 1417 -----FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAK 1471
D C+ L +P +E C+ CP W CS SCG G +R+V C+
Sbjct: 954 DGEEILLDTQCQGLPRPEPQEACSLEPCP--PRWKVMSLGPCSASCGLGTARRSVACVQL 1011
Query: 1472 D-GSHLESDY--CKHLAKPHGHRKCRGGRCP-KWKAGAWSQCSVSCGRGVQQRHVGCQIG 1527
D G +E D C L +P C C +W G W +CSVSCG G+Q+R C +G
Sbjct: 1012 DQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC-LG 1070
Query: 1528 THKIARETE--CNPYTRPESERDCQGPRC 1554
A C +P + R C C
Sbjct: 1071 PQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 156 bits (394), Expect = 2e-37
Identities = 128/450 (28%), Positives = 180/450 (40%), Gaps = 77/450 (17%)
Query: 1338 GACSSTCAGGSQRRVVVCQDENGYTANDCVERIK-------PDEQRACESGPCPQ-WAYG 1389
G CS +C G + C D+ + VE ++ P AC PCP WA G
Sbjct: 662 GPCSVSCGAGLRWVNYSCLDQ---ARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG 718
Query: 1390 NWGECTKLCGGGIRTRLVVCQRSNG---ERFPDLSCEILDKPPD--REQCNTHACPHDAA 1444
++G C+ CGGG+R R V C + G + P C + P E CN CP A
Sbjct: 719 DFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCP--AR 776
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCM-AKDG------------------------------ 1473
W SSC+ + G G N C+ DG
Sbjct: 777 WEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPG 836
Query: 1474 -SHLESDYCKHLA-KPHGHRKCRGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKI 1531
HL++ A P G + W A S CSVSCGRG+ + C ++
Sbjct: 837 WGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGS-CSVSCGRGLMELRFLCMDSALRV 895
Query: 1532 ARETE-CNPYTRPESERD-CQGPRCPLYTWRAEEWQ----ECTKTCGEGSRYRKVVCV-- 1583
+ E C ++P S R+ CQ CP WQ C+ +CG G R + C
Sbjct: 896 PVQEELCGLASKPGSRREVCQAVPCPA------RWQYKLAACSVSCGRGVVRRILYCARA 949
Query: 1584 ---DDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCS 1640
DD + + +C RP +E+CSL+PC W CS +CG G +R V+C
Sbjct: 950 HGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACV 1009
Query: 1641 EIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQR 1700
++ G+ + +P + PC + DC + W VG W CSVSCG G+ +R
Sbjct: 1010 QLDQGQ---DVEVDEAACAALVRPEASVPCLIADC--TYRWHVGTWMECSVSCGDGIQRR 1064
Query: 1701 SVQCLTNEDQ---PSHLCHTDLKPEERKTC 1727
CL + Q P+ C KP + C
Sbjct: 1065 RDTCLGPQAQAPVPADFCQHLPKPVTVRGC 1094
Score = 130 bits (327), Expect = 1e-29
Identities = 128/537 (23%), Positives = 194/537 (36%), Gaps = 95/537 (17%)
Query: 964 KYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWT-ECSKSCDGGTQRRRA 1022
+Y G + D F PKP W ++A CS SC G +
Sbjct: 629 RYGEEYGNLTRPDITFTYFQPKPRQ-----------AWVWAAVRGPCSVSCGAGLRWVNY 677
Query: 1023 ICVN-TRNDVLDDSKC--THQEKVTIQRCSEFPCPQ-WKSGDWSECLVTCGKGHKHRQVW 1078
C++ R ++++ +C + Q + C PCP W GD+ C +CG G + R V
Sbjct: 678 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVR 737
Query: 1079 CQFGEDRLNDRM------CDPETKPTSMQTCQQPEC-ASWQAGPWGQCSVTCGQGYQLRA 1131
C + L + + +++TC C A W+ C+ G G L
Sbjct: 738 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALEN 797
Query: 1132 VKCIIGT--YMSVVDDNDCNAATRPTDTQDCELPSCHP------PPAAPETRRSTYSAPR 1183
C+ G + V + + + + C SC P +A E S + + R
Sbjct: 798 ETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIR 857
Query: 1184 TQWRFGS-WTP----CSATCGKGTRMRYVSCRDENGSV-ADESACATLPRPVAKEE-CSV 1236
T + WTP CS +CG+G C D V E C +P ++ E C
Sbjct: 858 TGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQA 917
Query: 1237 TPCGQWKALDWSSCSVTCGQGRATRQVMCV-----NYSDHVIDRSECDQDYIPETDQDCS 1291
PC ++CSV+CG+G R + C + + ++ ++C PE + CS
Sbjct: 918 VPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACS 977
Query: 1292 MSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRR 1351
+ PCP R W+ G CS++C G+ RR
Sbjct: 978 LEPCPPR---------------------------------WKVMSLGPCSASCGLGTARR 1004
Query: 1352 VVVC-QDENGYTAN----DCVERIKPDEQRACESGPCP-QWAYGNWGECTKLCGGGIRTR 1405
V C Q + G C ++P+ C C +W G W EC+ CG GI+ R
Sbjct: 1005 SVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRR 1064
Query: 1406 LVVCQRSNGER-FPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSVSCGRGH 1461
C + P C+ L KP C C A CGR H
Sbjct: 1065 RDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGA------------CGRQH 1109
Score = 72.4 bits (176), Expect = 4e-12
Identities = 72/259 (27%), Positives = 101/259 (38%), Gaps = 41/259 (15%)
Query: 1509 CSVSCGRGVQQRHVGCQIGTHKIARET-ECNPYTRPESERD-CQGPRCPLYTWRAEEWQE 1566
CSVSCG G++ + C K ET +C +P + + C CP Y W ++
Sbjct: 664 CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPY-WAVGDFGP 722
Query: 1567 CTKTCGEGSRYRKVVCVDDNKN---EVHGARC--DVSKRPVDRESCSLQPCEYVWITGEW 1621
C+ +CG G R R V CV+ + + ARC + V E+C+ QPC W E
Sbjct: 723 CSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEP 782
Query: 1622 SECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCP----- 1676
S C+ G G +C G + E + P+ PC CP
Sbjct: 783 SSCTSAGGAGLALENETC---VPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 839
Query: 1677 ---------VSATW---RVGN-----W----GSCSVSCGVGVMQRSVQCLTNE---DQPS 1712
+ W R G W GSCSVSCG G+M+ C+ +
Sbjct: 840 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 899
Query: 1713 HLCHTDLKP-EERKTCRNV 1730
LC KP R+ C+ V
Sbjct: 900 ELCGLASKPGSRREVCQAV 918
Score = 32.0 bits (71), Expect = 6.0
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 6/55 (10%)
Query: 1388 YGNWGE---CTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHAC 1439
+ +WG C++ CGGG+ TR C F +C D E CNT AC
Sbjct: 356 WSSWGPRSPCSRSCGGGVVTRRRQCNNPR-PAFGGRACVGADL--QAEMCNTQAC 407
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 315 bits (807), Expect = 3e-85
Identities = 236/807 (29%), Positives = 337/807 (41%), Gaps = 130/807 (16%)
Query: 627 CVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRC 686
C+G ++K CNT C + R R+ QCA ++ K F + W P ++ + +C
Sbjct: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPF----MGRFYEWEP-FAEVKGNRKC 345
Query: 687 KLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCG 746
+L C+ G Y + ++VIDGTPC Q+ ICV G C+ GCD L S DKCGVCG
Sbjct: 346 ELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCG 405
Query: 747 GDNSSCKTVAGTFN--TVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGE 804
GDN+ C+ V+G F GY+ VV IP GAT I++ + S +NYLAL S G
Sbjct: 406 GDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKS-----NNYLALRSRSGR 460
Query: 805 FLLNGNFVVTMAKREIRIGNAVVEYSG----SETAVERINSTDRIEQELLLQVLSVGKLY 860
++NGN+ + + G + Y S TA E + + +L V + +
Sbjct: 461 SIINGNWAIDRPGK-YEGGGTMFTYKRPNEISSTAGESFLAEGPTNE--ILDVYMIHQQP 517
Query: 861 NPDVRYSFNIPIED--KPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRC 918
NP V Y + I + PQ P + +P G+ + E +Q ++++
Sbjct: 518 NPGVHYEYVIMGTNAISPQV------PPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKE 571
Query: 919 D-RLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDD 977
D R P T +R D + D
Sbjct: 572 DLRGEAPEMFTSESAQTFPVR----------------------------HPDRFSPHRPD 603
Query: 978 GFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVN-TRNDVLDDSK 1036
P+P R + W+ TECS +C G+Q CV+ + ++ +S
Sbjct: 604 NLVPPAPQPPRRSR------DHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESY 657
Query: 1037 CTHQEKVTIQR--CSEFPCPQ-WKSGDWSECLVTCGKGHKHRQVWC-QFGEDR---LNDR 1089
C K T + C+ FPCP W G+WSEC TCG G +HRQV C Q +R +
Sbjct: 658 CDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPY 717
Query: 1090 MCDPETKPTSMQTCQQPECASWQAGP-WGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC 1148
C KP + TCQ C+ WQ W CSV CG G + R VKC+ VVDD +C
Sbjct: 718 RCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCV-SNIGDVVDDEEC 776
Query: 1149 NAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTP-CSATCGKGTRMRYV 1207
N RP D ++C++ C W W+ CSA CG G R R V
Sbjct: 777 NMKLRPNDIENCDMGPC-----------------AKSWFLTEWSERCSAECGAGVRTRSV 819
Query: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPCG---QWKALDWSSCSVTCGQGRATRQVM 1264
C + S C RP C PC +W A WS CS+ CG G R+V+
Sbjct: 820 VCMTNHVSSLPLEGCGN-NRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVI 878
Query: 1265 CVNYSD---HVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASP 1321
CV + V+D SEC P + Q C + PC
Sbjct: 879 CVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPC-------------------------- 912
Query: 1322 SRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESG 1381
G +W + W CS +C GG + R V C ++ +N C ++KP+E+ +C
Sbjct: 913 -------GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQ 965
Query: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVV 1408
C N + C ++ RL V
Sbjct: 966 DCVPEVDENCKDKYYNCNVVVQARLCV 992
Score = 208 bits (529), Expect = 5e-53
Identities = 127/368 (34%), Positives = 174/368 (47%), Gaps = 23/368 (6%)
Query: 1386 WAYGNWGECTKLCGGGIRTRLVVC-QRSNGERFPDLSCEILDKP-PDREQCNTHACPHDA 1443
W EC+ CG G + + C RS E P+ C+ KP P+ E CN CP A
Sbjct: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCP--A 678
Query: 1444 AWSTGPWSSCSVSCGRGHKQRNVYCM---AKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
W G WS CS +CG G + R V C A ++ C+HL KP C+ C +
Sbjct: 679 FWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSE 738
Query: 1501 WKAGA-WSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTW 1559
W+ W+ CSV CG G + R V C + + ECN RP +C C +W
Sbjct: 739 WQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAK-SW 797
Query: 1560 RAEEWQE-CTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC--EYVW 1616
EW E C+ CG G R R VVC+ ++ + + C + RP + C PC + W
Sbjct: 798 FLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTGKVEW 856
Query: 1617 ITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQ-PPSVHPCYLRDC 1675
G WS+CS+ CG G +QR V C K + C + PPS C+L+ C
Sbjct: 857 FAGSWSQCSIECGSGTQQREVICVR----KNADTFEVLDPSECSFLEKPPSQQSCHLKPC 912
Query: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNC-- 1733
A W W CS SC G R V+CL+++ S+LC LKPEER++C N +C
Sbjct: 913 --GAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESC-NPQDCVP 969
Query: 1734 ELPQNCKE 1741
E+ +NCK+
Sbjct: 970 EVDENCKD 977
Score = 188 bits (477), Expect = 5e-47
Identities = 118/416 (28%), Positives = 173/416 (41%), Gaps = 69/416 (16%)
Query: 1097 PTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTD 1156
P + Q ++ +W+ +CS TCG+G Q +C+ + ++ C+++ +PT
Sbjct: 607 PPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTP 666
Query: 1157 TQD-CELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRD---E 1212
++ C + C PA W G W+ CS TCG G + R V CR
Sbjct: 667 EEEPCNIFPC---PAF--------------WDIGEWSECSKTCGLGMQHRQVLCRQVYAN 709
Query: 1213 NGSVADESACATLPRPVAKEECSVTPCGQWKA-LDWSSCSVTCGQGRATRQVMCVNYSDH 1271
C L +P C + C +W+ DW+SCSV CG G+ TR V CV+
Sbjct: 710 RSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD 769
Query: 1272 VIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQ 1331
V+D EC+ P ++C M PC +
Sbjct: 770 VVDDEECNMKLRPNDIENCDMGPCAK---------------------------------S 796
Query: 1332 WRTGPWGA-CSSTCAGGSQRRVVVCQDEN--GYTANDCVERIKPDEQRACESGPCP---Q 1385
W W CS+ C G + R VVC + C +P E C++GPC +
Sbjct: 797 WFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN-RPAEATPCDNGPCTGKVE 855
Query: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDL---SCEILDKPPDREQCNTHACPHD 1442
W G+W +C+ CG G + R V+C R N + F L C L+KPP ++ C H P
Sbjct: 856 WFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSC--HLKPCG 913
Query: 1443 AAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
A W + WS CS SC G + R V C++ D + S+ C KP C C
Sbjct: 914 AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMT--LSNLCDPQLKPEERESCNPQDC 967
Score = 40.4 bits (93), Expect = 0.017
Identities = 13/27 (48%), Positives = 17/27 (62%)
Query: 589 GSWGSWSPFGTCSRTCGGGIKTAIREC 615
G WG+W P+ CSR+C GG+ R C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 295 bits (756), Expect = 2e-79
Identities = 245/915 (26%), Positives = 370/915 (40%), Gaps = 172/915 (18%)
Query: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKR 647
DG+W +W + CSRTCGGG ++R C G+ C G+ +++K+C+ C
Sbjct: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
Query: 648 DFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVID 707
DFR +QC+ ++ + + W+P+Y+ C L C G +L +V+D
Sbjct: 129 DFRAQQCSAYNDVQYQGH----YYEWLPRYNDPAAP--CALKCHAQGQNLVVELAPKVLD 182
Query: 708 GTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYG-- 765
GT C D+ D+C+ G+C+ GCD L S A+ D CGVC GD S+C+ V G + H
Sbjct: 183 GTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKS-HVSPE 241
Query: 766 --YNTVVRIPAGATNIDVR----QHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKRE 819
V+ +P G+ ++ + H F L SKGE N V
Sbjct: 242 KREENVIAVPLGSRSVRITVKGPAHLFIESK------TLQGSKGEHSFNSPGVFL----- 290
Query: 820 IRIGNAVVEYS-GSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQ 878
+ N VE+ GSE T +I L+ + RY+ +D Q
Sbjct: 291 --VENTTVEFQRGSE------RQTFKIPGPLMADFIF-------KTRYT---AAKDSVVQ 332
Query: 879 FYWN---SHGPWQACSKPCQ-----GERKRKLVCTRESDQLTVSDQRCDRLPQ---PGHI 927
F++ SH Q PC G + C + V D C P+ P
Sbjct: 333 FFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPK 392
Query: 928 TEPCGTD-CDL-----------------RWHVASRSECSAQCGLGYRTLDIYCAKYSRLD 969
+ C D C RW + CS CG G + C + S +
Sbjct: 393 LKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEES-MH 451
Query: 970 GKTEKVDDGFCSSHPKPSNREKCS-GECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTR 1028
G+ +V++ C PKP + C+ +C W W++C+ +C G + R +C+N R
Sbjct: 452 GEILQVEEWKCMYAPKPKVMQTCNLFDCPK--WIAMEWSQCTVTCGRGLRYRVVLCINHR 509
Query: 1029 NDVLDDSKCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLND 1088
+ + C Q K+ I+ P P +K + S + + W + ++
Sbjct: 510 GEHV--GGCNPQLKLHIKEECVIPIPCYKPKEKSPV--------EAKLPWLKQAQELEET 559
Query: 1089 RMCDPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKC-IIGTYMSV---VD 1144
R+ E PT + PE PW CS TCG G Q+R VKC ++ T+ +
Sbjct: 560 RIATEE--PTFI-----PE-------PWSACSTTCGPGVQVREVKCRVLLTFTQTETELP 605
Query: 1145 DNDCNAATRPTDTQDCELPSCHPPPAA-------PETRRSTYSAPRTQWRFGSWTPCSAT 1197
+ +C PT+ + C L +C PA+ PE +TY W + +TPC+AT
Sbjct: 606 EEECEGPKLPTE-RPCLLEACDESPASRELDIPLPEDSETTY-----DWEYAGFTPCTAT 659
Query: 1198 CGKGTRMRYVSC-RDENGSVADESACATLPRPVA-KEECSVTPC-GQWKALDWSSCSVTC 1254
C G + C + ++S C + RP A + C+ PC +W W CS TC
Sbjct: 660 CVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATC 719
Query: 1255 GQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDY 1314
G G TR V C++ + EC +D P Q C+ CP
Sbjct: 720 GVGIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDCPP----------------- 761
Query: 1315 RPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQD--ENGYTAN---DCVER 1369
W W CS TC GG+Q R V C+ +G N + +
Sbjct: 762 ----------------GWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQG 805
Query: 1370 IKPDEQRACESGPC-PQWAYGNWGECTKLCGGGIRTRLVVCQR--SNGERFP--DLSCEI 1424
K ++C C P A G+W +C+ CG GI+ R VCQR + G R P ++ C
Sbjct: 806 PKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRD 865
Query: 1425 LDKPPDREQCNTHAC 1439
L P C C
Sbjct: 866 LPGLPLVRSCQMPEC 880
Score = 225 bits (574), Expect = 3e-58
Identities = 152/526 (28%), Positives = 228/526 (43%), Gaps = 64/526 (12%)
Query: 1105 QPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-----NAATRPTDTQD 1159
QP W+ + C+VTCG GYQL + +C+ VV D+ C N +P ++
Sbjct: 337 QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPK-LKE 395
Query: 1160 CELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEN--GSV- 1216
C + C E + P +W WT CS +CG G + R C +E+ G +
Sbjct: 396 CSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEIL 455
Query: 1217 -ADESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNY-SDHVID 1274
+E C P+P + C++ C +W A++WS C+VTCG+G R V+C+N+ +HV
Sbjct: 456 QVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV-- 513
Query: 1275 RSECDQDYIPETDQDCSMS-PC---PQRTP-DSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
C+ ++C + PC +++P ++ L E R A+ T +
Sbjct: 514 -GGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFI--- 569
Query: 1330 NQWRTGPWGACSSTCAGGSQRRVVVC-------QDENGYTANDCVERIKPDEQ----RAC 1378
PW ACS+TC G Q R V C Q E +C P E+ AC
Sbjct: 570 ----PEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEAC 625
Query: 1379 ESGPCPQ---------------WAYGNWGECTKLCGGGIRTRLVVCQR-SNGERFPDLSC 1422
+ P + W Y + CT C GG + + VC + D C
Sbjct: 626 DESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLC 685
Query: 1423 EILDKPPDREQ-CNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYC 1481
+++ +PP Q CNT CP W G W CS +CG G + R+VYC+ + + C
Sbjct: 686 DMVHRPPAMSQACNTEPCP--PRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEEC 743
Query: 1482 KHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVSCGRGVQQRHVGCQ----IGTHKIARETE 1536
+ KPH + C CP W W QCS +CG G Q R V C+ G+ +
Sbjct: 744 RD-EKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDEL 802
Query: 1537 CNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVC 1582
C + S + C CP + +W +C+ +CG G + RK VC
Sbjct: 803 CQG-PKASSHKSCARTDCPPHL-AVGDWSKCSVSCGVGIQRRKQVC 846
Score = 202 bits (514), Expect = 3e-51
Identities = 151/570 (26%), Positives = 228/570 (40%), Gaps = 94/570 (16%)
Query: 1241 QWKALDWSSCSVTCGQGRATRQVMCVNYS-DHVIDRSECDQDYIPETDQ------DCSMS 1293
QW+ D+ C+VTCG G CV+ V+ C Y PE + +CSM
Sbjct: 342 QWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCH--YYPENVKPKPKLKECSMD 399
Query: 1294 PCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVV 1353
PCP + D P+ + PR W PW ACS +C GG QRR
Sbjct: 400 PCP--SSDGFKEIMPYDHFQPLPR--------------WEHNPWTACSVSCGGGIQRRSF 443
Query: 1354 VCQDENGYTAN------DCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLV 1407
VC +E+ + C+ KP + C CP+W W +CT CG G+R R+V
Sbjct: 444 VCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVV 503
Query: 1408 VCQRSNGERF----PDLSCEILD---------KPPDR--------------EQCNTHACP 1440
+C GE P L I + KP ++ E T
Sbjct: 504 LCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIAT 563
Query: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYC-----MAKDGSHLESDYCKHLAKPHGHRKCRG 1495
+ + PWS+CS +CG G + R V C + + L + C+ P R C
Sbjct: 564 EEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPT-ERPCLL 622
Query: 1496 GRCPK--------------------WKAGAWSQCSVSCGRGVQQRHVGC-QIGTHKIARE 1534
C + W+ ++ C+ +C G Q+ C I T + +
Sbjct: 623 EACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVND 682
Query: 1535 TECNPYTRPES-ERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGA 1593
+ C+ RP + + C CP W W C+ TCG G + R V C+ +
Sbjct: 683 SLCDMVHRPPAMSQACNTEPCPP-RWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPE 741
Query: 1594 RCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSY 1653
C ++P ++C+ C W EW +CS TCG G + R V+C ++ T S
Sbjct: 742 ECR-DEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSD 800
Query: 1654 QTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSH 1713
+ C G + S C DCP VG+W CSVSCGVG+ +R C +
Sbjct: 801 EL---CQGPKASSHKSCARTDCPPHLA--VGDWSKCSVSCGVGIQRRKQVCQRLAAKGRR 855
Query: 1714 LCHTDLKPEERKTCRNVYNCELPQNCKEVK 1743
+ +++ + V +C++P+ C ++K
Sbjct: 856 IPLSEMMCRDLPGLPLVRSCQMPE-CSKIK 884
Score = 197 bits (500), Expect = 1e-49
Identities = 161/582 (27%), Positives = 226/582 (38%), Gaps = 118/582 (20%)
Query: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTR-NDVLDDSKCTH-----QEKVTIQRCSEFPCP 1054
WR + + C+ +C GG Q A CV+ R V+ D C + + K ++ CS PCP
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 1055 ------------------QWKSGDWSECLVTCGKGHKHRQVWC----QFGED-RLNDRMC 1091
+W+ W+ C V+CG G + R C GE ++ + C
Sbjct: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
Query: 1092 DPETKPTSMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAA 1151
KP MQTC +C W A W QC+VTCG+G + R V CI V CN
Sbjct: 463 MYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV---GGCNPQ 519
Query: 1152 TRPTDTQDCELP-SCHPP-------------PAAPETRRSTYSAPRTQWRFGSWTPCSAT 1197
+ ++C +P C+ P A E + + + W+ CS T
Sbjct: 520 LKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTT 579
Query: 1198 CGKGTRMRYVSCR-------DENGSVADESACATLP--RPVAKEECSVTPCGQ------- 1241
CG G ++R V CR E +E LP RP E C +P +
Sbjct: 580 CGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLP 639
Query: 1242 --------WKALDWSSCSVTCGQGRATRQVMCVN-YSDHVIDRSECDQDYIPET-DQDCS 1291
W+ ++ C+ TC G +C++ + ++ S CD + P Q C+
Sbjct: 640 EDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACN 699
Query: 1292 MSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRR 1351
PCP R W G WG CS+TC G Q R
Sbjct: 700 TEPCPPR---------------------------------WHVGSWGPCSATCGVGIQTR 726
Query: 1352 VVVC--QDENGYTANDCVERIKPDEQRACESGPCPQ-WAYGNWGECTKLCGGGIRTRLVV 1408
V C E +C + KP +AC CP W W +C++ CGGG + R V
Sbjct: 727 DVYCLHPGETPAPPEECRDE-KPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVT 785
Query: 1409 C-QRSNGERFPDLSCEILDKP--PDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRN 1465
C Q F +LS E+ P + C CP A G WS CSVSCG G ++R
Sbjct: 786 CRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLA--VGDWSKCSVSCGVGIQRRK 843
Query: 1466 VYC--MAKDGSH--LESDYCKHLAKPHGHRKCRGGRCPKWKA 1503
C +A G L C+ L R C+ C K K+
Sbjct: 844 QVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKS 885
Score = 133 bits (334), Expect = 2e-30
Identities = 78/253 (30%), Positives = 119/253 (47%), Gaps = 18/253 (7%)
Query: 869 NIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKL-VCTRESDQLTVSDQRCDRLPQPGHI 927
+IP+ + + Y + + C+ C G + + VC Q TV+D CD + +P +
Sbjct: 635 DIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAM 694
Query: 928 TEPCGTD-CDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP 986
++ C T+ C RWHV S CSA CG+G +T D+YC E+ D KP
Sbjct: 695 SQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD------EKP 748
Query: 987 SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRND----VLDDSKCTHQEK 1042
+ C+ GW W +CS++C GGTQ RR C D L D C +
Sbjct: 749 HALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKA 808
Query: 1043 VTIQRCSEFPCPQWKS-GDWSECLVTCGKGHKHRQVWCQFGEDR-----LNDRMCDPETK 1096
+ + C+ CP + GDWS+C V+CG G + R+ CQ + L++ MC
Sbjct: 809 SSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPG 868
Query: 1097 PTSMQTCQQPECA 1109
+++CQ PEC+
Sbjct: 869 LPLVRSCQMPECS 881
Score = 132 bits (331), Expect = 4e-30
Identities = 94/312 (30%), Positives = 127/312 (40%), Gaps = 31/312 (9%)
Query: 1349 QRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGG-GIRTRLV 1407
+ R+V Q Y R ++ P W GNW C+ CG G R +
Sbjct: 1391 ESRIVFLQGHKKYILQATNTRTNSNDPTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRP 1450
Query: 1408 VCQRSNGERFPDLSCEILDKP-PDREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNV 1466
C +NG+ + C+ L KP E CN CP A W T WS CSVSCG G+ R V
Sbjct: 1451 QCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCP--ARWFTSVWSQCSVSCGEGYHSRQV 1508
Query: 1467 YCMAKDGSH----LESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSC-GRGV--QQ 1519
C + + C +P G + C G C +W+ G ++C C GR V QQ
Sbjct: 1509 TCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPG--NRCPGRCMGRAVRMQQ 1566
Query: 1520 RHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRK 1579
RH CQ + ++ C+ RP R+C C + W W+ CT CG G + RK
Sbjct: 1567 RHTACQHN----SSDSNCDDRKRPTLRRNCTSGACDV-CWHTGPWKPCTAACGRGFQSRK 1621
Query: 1580 VVCVDDNK-NEVHGARCDVSKRPVDRESCSLQPCE--------YVWITGEWSECSVTCGK 1630
V C+ V C K+P+ C C+ Y + CS+
Sbjct: 1622 VDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSL---D 1678
Query: 1631 GYKQRLV-SCSE 1641
YKQR SC E
Sbjct: 1679 RYKQRCCQSCQE 1690
Score = 126 bits (316), Expect = 2e-28
Identities = 80/264 (30%), Positives = 109/264 (41%), Gaps = 37/264 (14%)
Query: 1440 PHDAAWSTGPWSSCSVSCGR-GHKQRNVYCMAKDGSHLESDYCKHLAKP-HGHRKCRGGR 1497
P + W G WS CS +CG G + + C+ +G + C HL KP G C
Sbjct: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
Query: 1498 CP-KWKAGAWSQCSVSCGRGVQQRHVGCQI----GTHKIARETECNPYTRPESERDCQGP 1552
CP +W WSQCSVSCG G R V C+ GT ++ C P RP + C G
Sbjct: 1483 CPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGH 1542
Query: 1553 RCPLYTWRAEEWQECTKTC-GEGSRY--RKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
C + E C C G R R C ++ + + CD KRP R +C+
Sbjct: 1543 PCVQW----EPGNRCPGRCMGRAVRMQQRHTACQHNSSD----SNCDDRKRPTLRRNCTS 1594
Query: 1610 QPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHP 1669
C+ W TG W C+ CG+G++ R V C I+ +P +
Sbjct: 1595 GACDVCWHTGPWKPCTAACGRGFQSRKVDC-----------------IHTRSCKPVAKRH 1637
Query: 1670 CYLRDCPVSATWRVGNWGSCSVSC 1693
C + P+S WR SC C
Sbjct: 1638 CVQKKKPIS--WRHCLGPSCDRDC 1659
Score = 107 bits (266), Expect = 1e-22
Identities = 73/246 (29%), Positives = 109/246 (44%), Gaps = 20/246 (8%)
Query: 873 EDKPQQFYWNSHGPWQACSKPC--QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEP 930
E PQ+ +W G W CS C G R ++ C + Q VS+ CD L +P EP
Sbjct: 1420 EPPPQEPFWEP-GNWSHCSATCGHLGARIQRPQCVMANGQ-EVSEALCDHLQKPLAGFEP 1477
Query: 931 CG-TDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNR 989
C DC RW + S+CS CG GY + + C K ++ +G + V C+ +P R
Sbjct: 1478 CNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTC-KRTKANGTVQVVSPRACAPKDRPLGR 1536
Query: 990 EKCSGECNTGGWRYSAWTECSKSCDGGT---QRRRAICVNTRNDVLDDSKCTHQEKVTIQ 1046
+ C G ++ C C G Q+R C + + DS C +++ T++
Sbjct: 1537 KPCFGHPCV---QWEPGNRCPGRCMGRAVRMQQRHTACQHNSS----DSNCDDRKRPTLR 1589
Query: 1047 R-CSEFPCPQ-WKSGDWSECLVTCGKGHKHRQVWCQFGED--RLNDRMCDPETKPTSMQT 1102
R C+ C W +G W C CG+G + R+V C + R C + KP S +
Sbjct: 1590 RNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRH 1649
Query: 1103 CQQPEC 1108
C P C
Sbjct: 1650 CLGPSC 1655
Score = 99.8 bits (247), Expect = 2e-20
Identities = 69/238 (28%), Positives = 98/238 (41%), Gaps = 21/238 (8%)
Query: 939 WHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKP-SNREKCSGEC 996
W + S CSA CG LG R C ++V + C KP + E C+
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVM-----ANGQEVSEALCDHLQKPLAGFEPCNIRD 1482
Query: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICVNTRND----VLDDSKCTHQEKVTIQR-CSEF 1051
W S W++CS SC G R+ C T+ + V+ C +++ ++ C
Sbjct: 1483 CPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGH 1542
Query: 1052 PCPQWKSGDWSECLVTC-GKGHK--HRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
PC QW+ G+ C C G+ + R CQ +D CD +PT + C C
Sbjct: 1543 PCVQWEPGN--RCPGRCMGRAVRMQQRHTACQHNS---SDSNCDDRKRPTLRRNCTSGAC 1597
Query: 1109 -ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
W GPW C+ CG+G+Q R V CI V C +P + C PSC
Sbjct: 1598 DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 99.4 bits (246), Expect = 3e-20
Identities = 73/251 (29%), Positives = 99/251 (39%), Gaps = 42/251 (16%)
Query: 1163 PSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRDENGSVADESA 1221
P+ PPP P W G+W+ CSATCG G R++ C NG E+
Sbjct: 1417 PTGEPPPQEPF------------WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEAL 1464
Query: 1222 CATLPRPVAK-EECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMC----VNYSDHVIDR 1275
C L +P+A E C++ C +W WS CSV+CG+G +RQV C N + V+
Sbjct: 1465 CDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSP 1524
Query: 1276 SECDQDYIPETDQDCSMSPCPQRTPDS-----------------GLAQHPFQNEDYRPRS 1318
C P + C PC Q P + QH + + R
Sbjct: 1525 RACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRK 1584
Query: 1319 ASPSRTHVLGGN---QWRTGPWGACSSTCAGGSQRRVVVC---QDENGYTANDCVERIKP 1372
R + G W TGPW C++ C G Q R V C + CV++ KP
Sbjct: 1585 RPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKP 1644
Query: 1373 DEQRACESGPC 1383
R C C
Sbjct: 1645 ISWRHCLGPSC 1655
Score = 97.8 bits (242), Expect = 9e-20
Identities = 68/262 (25%), Positives = 107/262 (40%), Gaps = 51/262 (19%)
Query: 1001 WRYSAWTECSKSCDG-GTQRRRAICVNTRNDVLDDSKCTHQEK--VTIQRCSEFPCP-QW 1056
W W+ CS +C G + +R CV + ++ C H +K + C+ CP +W
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
Query: 1057 KSGDWSECLVTCGKGHKHRQVWCQFGEDR-----LNDRMCDPETKPTSMQTCQQPECASW 1111
+ WS+C V+CG+G+ RQV C+ + ++ R C P+ +P + C C W
Sbjct: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQW 1547
Query: 1112 QAGPWGQCSVTC---GQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
+ G +C C Q R C + D++C+ RPT ++C +C
Sbjct: 1548 EPG--NRCPGRCMGRAVRMQQRHTACQHNS-----SDSNCDDRKRPTLRRNCTSGACD-- 1598
Query: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRP 1228
W G W PC+A CG+G + R V C +C +P
Sbjct: 1599 ---------------VCWHTGPWKPCTAACGRGFQSRKVDC-------IHTRSC----KP 1632
Query: 1229 VAKEECSVTPCGQWKALDWSSC 1250
VAK C + K + W C
Sbjct: 1633 VAKRHC----VQKKKPISWRHC 1650
Score = 97.4 bits (241), Expect = 1e-19
Identities = 75/238 (31%), Positives = 100/238 (42%), Gaps = 25/238 (10%)
Query: 1332 WRTGPWGACSSTCAG-GSQRRVVVCQDENGYTAND--CVERIKPDEQ-RACESGPCP-QW 1386
W G W CS+TC G++ + C NG ++ C KP C CP +W
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
Query: 1387 AYGNWGECTKLCGGGIRTRLVVCQR--SNG--ERFPDLSCEILDKPPDREQCNTHACPHD 1442
W +C+ CG G +R V C+R +NG + +C D+P R+ C H C
Sbjct: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC--- 1544
Query: 1443 AAWSTGPWSSCSVSC-GRG--HKQRNVYCMAKDGSHLESD-YCKHLAKPHGHRKCRGGRC 1498
W P + C C GR +QR+ C H SD C +P R C G C
Sbjct: 1545 VQWE--PGNRCPGRCMGRAVRMQQRHTAC-----QHNSSDSNCDDRKRPTLRRNCTSGAC 1597
Query: 1499 PK-WKAGAWSQCSVSCGRGVQQRHVGC-QIGTHKIARETECNPYTRPESERDCQGPRC 1554
W G W C+ +CGRG Q R V C + K + C +P S R C GP C
Sbjct: 1598 DVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 82.0 bits (201), Expect = 5e-15
Identities = 55/201 (27%), Positives = 75/201 (37%), Gaps = 57/201 (28%)
Query: 1559 WRAEEWQECTKTCGE-GSRYRKVVCVDDNKNEVHGARCDVSKRPVDR-ESCSLQPCEYVW 1616
W W C+ TCG G+R ++ CV N EV A CD ++P+ E C+++ C W
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
Query: 1617 ITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP------GTQPPSVHPC 1670
T WS+CSV+CG+GY R V+C K N + C G +P HPC
Sbjct: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRT---KANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Query: 1671 YL-------------------------------------------RDCPVSAT---WRVG 1684
R+C A W G
Sbjct: 1545 VQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCWHTG 1604
Query: 1685 NWGSCSVSCGVGVMQRSVQCL 1705
W C+ +CG G R V C+
Sbjct: 1605 PWKPCTAACGRGFQSRKVDCI 1625
Score = 69.3 bits (168), Expect = 3e-11
Identities = 92/411 (22%), Positives = 145/411 (35%), Gaps = 75/411 (18%)
Query: 1387 AYGNWGECTKLCGGGIRTRLVVC---QRSNGERFPDLSCEILDKPPDREQCNTHACP--- 1440
A+G+W +C++ CGGG L C + G+ +C D PPD E C
Sbjct: 80 AWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYN 139
Query: 1441 ------HDAAWS---TGPWSSCSVSCGRGHKQRNVYCMAK--DGSHLESDYCKHLAKPHG 1489
H W P + C++ C + V K DG+ +D
Sbjct: 140 DVQYQGHYYEWLPRYNDPAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGI- 198
Query: 1490 HRKCRGGRCPKWKAGAWSQ--CSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESER 1547
C+ C + + C V G G R V Q +H + E N P R
Sbjct: 199 ---CQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREENVIAVPLGSR 255
Query: 1548 DCQ-GPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV--HGARCDVSKRP--- 1601
+ + P + + + + +K GE S V + +N G+ K P
Sbjct: 256 SVRITVKGPAHLFIESKTLQGSK--GEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPL 313
Query: 1602 -----------VDRESCS----LQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGK 1646
++S QP + W ++ C+VTCG GY+ C +I +
Sbjct: 314 MADFIFKTRYTAAKDSVVQFFFYQPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKR 373
Query: 1647 ---ENYEYSYQTTINCPGTQPPSVHPCYLRDCPVS---------------ATWRVGNWGS 1688
++Y + Y + P + C + CP S W W +
Sbjct: 374 VVPDHYCHYYPENVK----PKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTA 429
Query: 1689 CSVSCGVGVMQRSVQCLTNEDQPSHL------CHTDLKPEERKTCRNVYNC 1733
CSVSCG G+ +RS C+ L C KP+ +TC N+++C
Sbjct: 430 CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTC-NLFDC 479
Score = 59.7 bits (143), Expect = 3e-08
Identities = 38/97 (39%), Positives = 43/97 (44%), Gaps = 12/97 (12%)
Query: 1611 PCEYVWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPP--SV 1667
P E W G WS CS TCG G + + C + G+E E C Q P
Sbjct: 1423 PQEPFWEPGNWSHCSATCGHLGARIQRPQCV-MANGQEVSEAL------CDHLQKPLAGF 1475
Query: 1668 HPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQC 1704
PC +RDCP A W W CSVSCG G R V C
Sbjct: 1476 EPCNIRDCP--ARWFTSVWSQCSVSCGEGYHSRQVTC 1510
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/136 (22%), Positives = 45/136 (33%), Gaps = 25/136 (18%)
Query: 886 PWQACSKPCQGE----RKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHV 941
P C C G ++R C S SD CD +P CD+ WH
Sbjct: 1549 PGNRCPGRCMGRAVRMQQRHTACQHNS-----SDSNCDDRKRPTLRRNCTSGACDVCWHT 1603
Query: 942 ASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGW 1001
C+A CG G+++ + C + C KP + C + W
Sbjct: 1604 GPWKPCTAACGRGFQSRKVDC------------IHTRSC----KPVAKRHCVQKKKPISW 1647
Query: 1002 RYSAWTECSKSCDGGT 1017
R+ C + C T
Sbjct: 1648 RHCLGPSCDRDCTDTT 1663
Score = 35.4 bits (80), Expect = 0.54
Identities = 20/69 (28%), Positives = 30/69 (43%), Gaps = 9/69 (13%)
Query: 987 SNREKCSGECNTGGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTI 1045
++R S E G W + W++CS++C GG C+ RN C Q +
Sbjct: 64 TSRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRN-------CEGQ-NIRY 115
Query: 1046 QRCSEFPCP 1054
+ CS CP
Sbjct: 116 KTCSNHDCP 124
Score = 32.7 bits (73), Expect = 3.5
Identities = 26/94 (27%), Positives = 38/94 (40%), Gaps = 14/94 (14%)
Query: 1523 GCQIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRA-EEWQECTKTCGEGSRYRKVV 1581
G Q T++ +T N TR + ++D W A +W +C++TCG G+ Y
Sbjct: 52 GEQFLTYRYDDQTSRN--TRSDEDKDGN--------WDAWGDWSDCSRTCGGGASYSLRR 101
Query: 1582 CVDDNKNEVHGAR---CDVSKRPVDRESCSLQPC 1612
C+ E R C P D E Q C
Sbjct: 102 CLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQC 135
Score = 31.6 bits (70), Expect = 7.9
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 11/73 (15%)
Query: 580 KEMDVPVTDGS-----WGSWSPFGTCSRTCGGGIKTAIRECNRPEPKN--GGKYC--VGR 630
+E+D+P+ + S W ++ F C+ TC GG + AI C + + C V R
Sbjct: 632 RELDIPLPEDSETTYDW-EYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHR 690
Query: 631 RMKF-KSCNTEPC 642
++CNTEPC
Sbjct: 691 PPAMSQACNTEPC 703
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 281 bits (719), Expect = 4e-75
Identities = 181/603 (30%), Positives = 267/603 (44%), Gaps = 132/603 (21%)
Query: 590 SWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKRDF 649
+WG WS + CSRTCGGG+ R C + ++GG CVG +SC TE C RDF
Sbjct: 28 TWGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESCPDGARDF 86
Query: 650 RDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGT 709
R EQCA FDG F RW+P YS ++C+L C G YY+ R+ V+DGT
Sbjct: 87 RAEQCAEFDGAEFQGR----RYRWLPYYSA---PNKCELNCIPKGENFYYKHREAVVDGT 139
Query: 710 PCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFNTVHYGYNTV 769
PC D+CV G CR GCDH L+S + DKC CGGD ++C VAGTF+
Sbjct: 140 PCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA-------- 191
Query: 770 VRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREIRIGNAVVEY 829
+D A+ + +GE+ LNG++ + A R + + ++ Y
Sbjct: 192 ----------------------NDLSRAVKNVRGEYYLNGHWTIEAA-RALPAASTILHY 228
Query: 830 S-GSE--TAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGP 886
G+E A ER+++ + L+++++S NP V Y +++P+
Sbjct: 229 ERGAEGDLAPERLHARGPTSEPLVIELISQEP--NPGVHYEYHLPL-------------- 272
Query: 887 WQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSE 946
R P PG W S S+
Sbjct: 273 ---------------------------------RRPSPG-----------FSWSHGSWSD 288
Query: 947 CSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCS-GEC-NTGGWRYS 1004
CSA+CG G+++ ++C +D E D C P+P++R C+ C T W+
Sbjct: 289 CSAECGGGHQSRLVFCT----IDH--EAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAG 342
Query: 1005 AWTECSKSCDGGTQRRRAICVNTR----NDVLDDSKCT--HQEKVTIQRCSEFPCPQWKS 1058
W CS SC GG+Q R C+++ + +++++C + IQ C+ C W
Sbjct: 343 PWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSP 402
Query: 1059 GDWSECLVTCGKGHKHRQVWCQFGE--DRLNDRMCDPETKPTSMQTCQQPEC-----ASW 1111
W EC V+CG G + R V C+ GE L+ C E +P + C +C +W
Sbjct: 403 EPWGECSVSCGVGVRKRSVTCR-GERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAW 461
Query: 1112 QAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAA--TRPTDTQDCELPSCHPPP 1169
G WG CS +C G + R V C IG + C + ++P D + C CH P
Sbjct: 462 HVGTWGLCSKSCSSGTRRRQVICAIG------PPSHCGSLQHSKPVDVEPCNTQPCHLPQ 515
Query: 1170 AAP 1172
P
Sbjct: 516 EVP 518
Score = 178 bits (451), Expect = 5e-44
Identities = 86/235 (36%), Positives = 121/235 (51%), Gaps = 12/235 (5%)
Query: 1386 WAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAW 1445
W++G+W +C+ CGGG ++RLV C + E +PD C+ +P DR CN H CP W
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
Query: 1446 STGPWSSCSVSCGRGHKQRNVYCMAKDGSHL----ESDYCKHL-AKPHGHRKCRGGRCPK 1500
GPW+ CS SCG G + R+VYC++ DG+ + E C L KP + C RC
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYT-- 1558
W W +CSVSCG GV++R V C+ + C+ RP C CPL +
Sbjct: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQ 459
Query: 1559 -WRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
W W C+K+C G+R R+V+C + + +PVD E C+ QPC
Sbjct: 460 AWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQ---HSKPVDVEPCNTQPC 511
Score = 147 bits (372), Expect = 8e-35
Identities = 138/539 (25%), Positives = 199/539 (36%), Gaps = 101/539 (18%)
Query: 984 PKP-SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEK 1042
P P S+ K + +T G +S W+ CS++C GG R C + R D S C +
Sbjct: 13 PAPGSSAPKVRRQSDTWG-PWSQWSPCSRTCGGGVSFRERPCYSQRRD--GGSSCVGPAR 69
Query: 1043 VTIQRCSEFPCPQWKSGDWSE-CLVTCG---KGHKHRQVWCQFGEDRLNDRMCDPETKPT 1098
+ + C CP +E C G +G ++R W + C+ P
Sbjct: 70 -SHRSCRTESCPDGARDFRAEQCAEFDGAEFQGRRYR--WLPYYS---APNKCELNCIPK 123
Query: 1099 SMQTCQQPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQ 1158
+ A P C G + C+ G+ V D++ +++ +
Sbjct: 124 GENFYYKHREAVVDGTP-------CEPG---KRDVCVDGSCRVVGCDHELDSSKQEDKCL 173
Query: 1159 DC--ELPSCHPPPA---APETRRSTYSAPRTQWRFGSWT--PCSATCGKGTRMRYVSCRD 1211
C + +C+P A + R+ + + G WT A T + Y R
Sbjct: 174 RCGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLNGHWTIEAARALPAASTILHYE--RG 231
Query: 1212 ENGSVADESACATLP--RPVAKEECS-----------------VTPCGQWKALDWSSCSV 1252
G +A E A P P+ E S +P W WS CS
Sbjct: 232 AEGDLAPERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSA 291
Query: 1253 TCGQGRATRQVMCV----NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHP 1308
CG G +R V C Y DH+ C + P + C++ PCP+
Sbjct: 292 ECGGGHQSRLVFCTIDHEAYPDHM-----CQRQPRPADRRSCNLHPCPET---------- 336
Query: 1309 FQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVE 1368
+W+ GPW CS++C GGSQ R V C +G + VE
Sbjct: 337 ---------------------KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVE 375
Query: 1369 RI-------KPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLS 1421
KP +AC C W+ WGEC+ CG G+R R V C+ G +
Sbjct: 376 EAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAA 435
Query: 1422 CEILDKPPDREQCNTHACP--HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLES 1478
C + D+PP E C CP D AW G W CS SC G ++R V C SH S
Sbjct: 436 CSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGS 494
Score = 141 bits (356), Expect = 5e-33
Identities = 155/602 (25%), Positives = 223/602 (37%), Gaps = 142/602 (23%)
Query: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQR-CSEFPCPQ---W 1056
W + +W++CS C GG Q R C ++ D C Q + +R C+ PCP+ W
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCT-IDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
Query: 1057 KSGDWSECLVTCGKGHKHRQVWCQFGEDR-LNDRMCDPET-----KPTSMQTCQQPECAS 1110
K+G W+ C +CG G + R V+C + + + + + E KP ++Q C CA+
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
Query: 1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPA 1170
W PWG+CSV+CG G + R+V C G S++ C+ RP T+ C C P
Sbjct: 400 WSPEPWGECSVSCGVGVRKRSVTC-RGERGSLLHTAACSLEDRPPLTEPCVHEDC--PLL 456
Query: 1171 APETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATL--PRP 1228
+ + W G+W CS +C GTR R V C ++ S C +L +P
Sbjct: 457 SDQA-----------WHVGTWGLCSKSCSSGTRRRQVIC-----AIGPPSHCGSLQHSKP 500
Query: 1229 VAKEECSVTPC-----------------GQWKAL--DWSSCSVTCGQGRATRQVMCVNYS 1269
V E C+ PC W L S S + GQ A ++
Sbjct: 501 VDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQESPASDSRGQWWAAQEHPSAR-G 559
Query: 1270 DHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
DH +R + P DQ +S P L Q P+Q RS S G
Sbjct: 560 DHRGERGD------PRGDQGTHLSAL---GPAPSLQQPPYQQP---LRSGS-------GP 600
Query: 1330 NQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYG 1389
+ R P G C +G+TA+ + P Q C PC Q YG
Sbjct: 601 HDCRHSPHGCC-----------------PDGHTAS-----LGPQWQ-GCPGAPCQQSRYG 637
Query: 1390 ------------NWGECTKLCG----GGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQ 1433
+ CTK G GG+ V + P ++P +
Sbjct: 638 CCPDRVSVAEGPHHAGCTKSYGGDSTGGMPRSRAVASTVHNTHQPQAQ---QNEPSECRG 694
Query: 1434 CNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKC 1493
C + A + GP G G C+ + SH Y P H
Sbjct: 695 SQFGCCYDNVATAAGP-------LGEG-------CVGQP-SHA---YPVRCLLPSAH--- 733
Query: 1494 RGGRCPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPR 1553
G C W A + SV G+ + + GC + A E EC + GPR
Sbjct: 734 --GSCADWAARWYFVASV--GQCNRFWYGGCHGNANNFASEQEC----MSSCQGSLHGPR 785
Query: 1554 CP 1555
P
Sbjct: 786 RP 787
Score = 139 bits (351), Expect = 2e-32
Identities = 90/249 (36%), Positives = 117/249 (46%), Gaps = 26/249 (10%)
Query: 1501 WKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP-LYTW 1559
W G+WS CS CG G Q R V C I H+ + C RP R C CP W
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTID-HEAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
Query: 1560 RAEEWQECTKTCGEGSRYRKVVCVDDN----KNEVHGARC-DVSKRPVDRESCSLQPCEY 1614
+A W C+ +CG GS+ R V C+ + + V A C + +P ++C+LQ C
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA- 398
Query: 1615 VWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCP-GTQPPSVHPCYLR 1673
W W ECSV+CG G ++R V+C G+ S T C +PP PC
Sbjct: 399 AWSPEPWGECSVSCGVGVRKRSVTCR----GERG---SLLHTAACSLEDRPPLTEPCVHE 451
Query: 1674 DCPVSA--TWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSH---LCHTDLKPEERKTCR 1728
DCP+ + W VG WG CS SC G +R V C PSH L H+ KP + + C
Sbjct: 452 DCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIG--PPSHCGSLQHS--KPVDVEPC- 506
Query: 1729 NVYNCELPQ 1737
N C LPQ
Sbjct: 507 NTQPCHLPQ 515
Score = 106 bits (265), Expect = 2e-22
Identities = 65/196 (33%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 1536 ECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARC 1595
E NP E + P P ++W W +C+ CG G + R V C D++ C
Sbjct: 259 EPNPGVHYEYHLPLRRPS-PGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHE-AYPDHMC 316
Query: 1596 DVSKRPVDRESCSLQPCEYV--WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSY 1653
RP DR SC+L PC W G W+ CS +CG G + R V C
Sbjct: 317 QRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEE 376
Query: 1654 QTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSH 1713
PG +PP++ C L+ C A W WG CSVSCGVGV +RSV C H
Sbjct: 377 AECAGLPG-KPPAIQACNLQRC---AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLH 432
Query: 1714 --LCHTDLKPEERKTC 1727
C + +P + C
Sbjct: 433 TAACSLEDRPPLTEPC 448
Score = 53.1 bits (126), Expect = 3e-06
Identities = 77/336 (22%), Positives = 124/336 (36%), Gaps = 81/336 (24%)
Query: 1445 WSTGPWSSCSVSCGRG--HKQRNVYCMAKDG---------SHLESDYCKHLAKPHGHRKC 1493
WS WS CS +CG G ++R Y +DG SH C+ + P G R
Sbjct: 32 WSQ--WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSHRS---CRTESCPDGARDF 86
Query: 1494 RGGRCPKWKA--------------GAWSQCSVSC---GRGVQQRHVGCQIGTHKIARETE 1536
R +C ++ A ++C ++C G +H + T
Sbjct: 87 RAEQCAEFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKH------REAVVDGTP 140
Query: 1537 CNPYTRPES-ERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARC 1595
C P R + C+ C +++ +C + G+G+ V D N++ A
Sbjct: 141 CEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFD-ANDLSRAVK 199
Query: 1596 DVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIY---TGKENYEYS 1652
+V EY ++ G W+ + + L + S I G E
Sbjct: 200 NVRG-------------EY-YLNGHWTIEAA-------RALPAASTILHYERGAEGDLAP 238
Query: 1653 YQTTINCPGTQP-----------PSVHPCY---LRDCPVSATWRVGNWGSCSVSCGVGVM 1698
+ P ++P P VH Y LR +W G+W CS CG G
Sbjct: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQ 298
Query: 1699 QRSVQC-LTNEDQPSHLCHTDLKPEERKTCRNVYNC 1733
R V C + +E P H+C +P +R++C N++ C
Sbjct: 299 SRLVFCTIDHEAYPDHMCQRQPRPADRRSC-NLHPC 333
Score = 38.5 bits (88), Expect = 0.064
Identities = 28/85 (32%), Positives = 35/85 (41%), Gaps = 7/85 (8%)
Query: 565 ECEPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGG 624
E PG H Y + +P P S GSWS CS CGGG ++ + C
Sbjct: 259 EPNPGVH--YEYHLPLRRPSPGFSWSHGSWSD---CSAECGGGHQSRLVFCTIDHEAYPD 313
Query: 625 KYCVG--RRMKFKSCNTEPCLKQKR 647
C R +SCN PC + KR
Sbjct: 314 HMCQRQPRPADRRSCNLHPCPETKR 338
Score = 34.7 bits (78), Expect = 0.93
Identities = 19/68 (27%), Positives = 34/68 (50%), Gaps = 6/68 (8%)
Query: 577 CVPKEMDVPVTDGSW--GSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKF 634
CV ++ + ++D +W G+W G CS++C G + C P + G + +
Sbjct: 448 CVHEDCPL-LSDQAWHVGTW---GLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDV 503
Query: 635 KSCNTEPC 642
+ CNT+PC
Sbjct: 504 EPCNTQPC 511
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 280 bits (717), Expect = 7e-75
Identities = 218/718 (30%), Positives = 311/718 (43%), Gaps = 93/718 (12%)
Query: 627 CVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRC 686
C G + ++C+ PC ++ D R QCA F+ + F G L +W P ++ + RC
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFM--GQL--YQWEP-FTEVQGSQRC 418
Query: 687 KLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCG 746
+L CR G Y + ++V DGT C DICV G C GCD +L S R D CGVCG
Sbjct: 419 ELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
Query: 747 GDNSSCKTVAG--TFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGE 804
GD+S+C+ V+G T GY ++ IPAGA + + Q S NYLAL G
Sbjct: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSS-----NYLALRGPGGR 533
Query: 805 FLLNGNFVVTMAKREIRIGNAVVEYSG---SETAVERINSTDRIEQELLLQVLSVGKLYN 861
++NGN+ V R G V Y+ E E +++ Q + V + + N
Sbjct: 534 SIINGNWAVD-PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPV--DVYMIFQEEN 590
Query: 862 PDVRYSFNI----PIEDKP---------QQFYWNSHGPWQACSKPCQ--GERKRKLVCTR 906
P V Y + I PI + P Q P +P + G +R++
Sbjct: 591 PGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQV---- 646
Query: 907 ESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYS 966
R ++P P H P G+ W S CSA CG G C S
Sbjct: 647 ----------RIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASCGKGVWRPIFLCI--S 693
Query: 967 RLDGKTEKVDDGFCSSHPKP-SNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAIC- 1024
R G E++D+ C++ +P ++ E C G W WT CS+SC GTQ R+ C
Sbjct: 694 RESG--EELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCR 751
Query: 1025 --VNTRNDVLDDSKCTHQEKVTI-QRCSEFPCPQWKSGD-WSECLVTCGKGHKHRQVWCQ 1080
+ +C H + I Q C C W+ G WS+C V CG+G + RQV C
Sbjct: 752 QEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCV 811
Query: 1081 FGE-DRLNDRMC-DPETKPTSMQTCQQPEC-ASWQAGPW-GQCSVTCGQGYQLRAVKCI- 1135
D ++++ C +P S + C C +W W +CS CG G Q R+V C+
Sbjct: 812 GNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLG 871
Query: 1136 ----IGTYMSVV---DDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRT-QWR 1187
+G C +RP D + C L C RT +W
Sbjct: 872 SGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCE----------------RTWRWY 915
Query: 1188 FGSWTPCSATCGKGTRMRYVSCRDENG---SVADESACATLPRPVAKEECSVTPC-GQWK 1243
G W CS+ CG GT+ R + C + G +V S C+ LPRP A + C C +W
Sbjct: 916 TGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWF 975
Query: 1244 ALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPD 1301
+ WS CS +C G TR+V C++ + + R C P + C+ PC QR D
Sbjct: 976 STPWSPCSRSCQGGTQTREVQCLSTNQTLSTR--CPPQLRPSRKRPCNSQPCSQRPDD 1031
Score = 198 bits (503), Expect = 5e-50
Identities = 124/391 (31%), Positives = 172/391 (43%), Gaps = 30/391 (7%)
Query: 1372 PDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVC-QRSNGERFPDLSCEILDKPP- 1429
P R P W C+ CG G+ + +C R +GE + SC +PP
Sbjct: 654 PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA 713
Query: 1430 DREQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAK---DGSHLESDYCKHLAK 1486
E C+ CP W G W+SCS SCG G + R + C + GS + + C HL +
Sbjct: 714 SPEPCHGTPCP--PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
Query: 1487 PHGHRKCRGGRCPKWKAGA-WSQCSVSCGRGVQQRHVGCQIGTHKIARETEC-NPYTRPE 1544
P+ + C+ C W+ G+ WSQCSV CGRG + R V C E EC + +P
Sbjct: 772 PNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
Query: 1545 SERDCQGPRCPLYTWRAEEWQ-ECTKTCGEGSRYRKVVCVDDNK---------NEVHGAR 1594
S C C W +W +C+ CG G + R VVC+ G
Sbjct: 832 SREACDMGPCTT-AWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQS 890
Query: 1595 CDVSKRPVDRESCSLQPCE--YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYS 1652
C RP D +CSL PCE + W TG W ECS CG G ++R + C K E++
Sbjct: 891 CPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIIC----VSKLGTEFN 946
Query: 1653 YQTTINCPGT-QPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQP 1711
+ NC +PP++ PC + C W W CS SC G R VQCL+
Sbjct: 947 VTSPSNCSHLPRPPALQPCQGQAC--QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL 1004
Query: 1712 SHLCHTDLKPEERKTCRNVYNCELPQN-CKE 1741
S C L+P ++ C + + P + CK+
Sbjct: 1005 STRCPPQLRPSRKRPCNSQPCSQRPDDQCKD 1035
Score = 195 bits (496), Expect = 3e-49
Identities = 127/413 (30%), Positives = 172/413 (41%), Gaps = 61/413 (14%)
Query: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGT-RMRYVSCRDENGSVADESACATL 1225
P AP R+ +P W+ + CSA+CGKG R ++ E+G DE +CA
Sbjct: 649 PQMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAG 708
Query: 1226 PRPVAKEE-CSVTPCGQ-WKALDWSSCSVTCGQGRATRQVMC---VNYSDHVIDRSECDQ 1280
RP A E C TPC W+A +W+SCS +CG G RQ+ C + C
Sbjct: 709 ARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGH 768
Query: 1281 DYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTG-PWGA 1339
P Q C + C W G PW
Sbjct: 769 LPRPNITQSCQLRLC----------------------------------GHWEVGSPWSQ 794
Query: 1340 CSSTCAGGSQRRVVVCQDENG--YTANDCVERI-KPDEQRACESGPCPQ-WAYGNWG-EC 1394
CS C G + R V C NG + +C +P + AC+ GPC W + +W +C
Sbjct: 795 CSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKC 854
Query: 1395 TKLCGGGIRTRLVVCQRSNGERFPDL---------SCEILDKPPDREQCNTHACPHDAAW 1445
+ CG GI+ R VVC S P SC +PPD C+ C W
Sbjct: 855 SAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRW 914
Query: 1446 STGPWSSCSVSCGRGHKQRNVYCMAKDGSHL---ESDYCKHLAKPHGHRKCRGGRC-PKW 1501
TGPW CS CG G ++R++ C++K G+ C HL +P + C+G C +W
Sbjct: 915 YTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRW 974
Query: 1502 KAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRC 1554
+ WS CS SC G Q R V C + T++ T C P RP +R C C
Sbjct: 975 FSTPWSPCSRSCQGGTQTREVQC-LSTNQ-TLSTRCPPQLRPSRKRPCNSQPC 1025
Score = 178 bits (452), Expect = 4e-44
Identities = 120/432 (27%), Positives = 182/432 (42%), Gaps = 73/432 (16%)
Query: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRN-DVLDDSKCTHQEK--VTIQRCSEFPCPQ-W 1056
W+ + CS SC G R +C++ + + LD+ C + + + C PCP W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 1057 KSGDWSECLVTCGKGHKHRQVWCQF----GEDRLNDRMCDPETKPTSMQTCQQPECASWQ 1112
++G+W+ C +CG G +HRQ+ C+ G + C +P Q+CQ C W+
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 1113 AG-PWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-NAATRPTDTQDCELPSCHPPPA 1170
G PW QCSV CG+G + R V+C+ G V + +C + +P + C++ C
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCV-GNNGDEVSEQECASGPPQPPSREACDMGPC----- 841
Query: 1171 APETRRSTYSAPRTQWRFGSWTP-CSATCGKGTRMRYVSC----------RDENGSVADE 1219
T W W+ CSA CG G + R V C + E G+ +
Sbjct: 842 ------------TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
Query: 1220 SACATLPRPVAKEECSVTPCGQ---WKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRS 1276
S C T RP CS+ PC + W W CS CG G R ++CV S
Sbjct: 890 S-CPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICV---------S 939
Query: 1277 ECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGP 1336
+ ++ + +CS P P A P Q + + R W + P
Sbjct: 940 KLGTEFNVTSPSNCSHLPRPP-------ALQPCQGQACQDR--------------WFSTP 978
Query: 1337 WGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECTK 1396
W CS +C GG+Q R V C N + C +++P +R C S PC Q + +
Sbjct: 979 WSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQCKDSSP 1038
Query: 1397 LCGGGIRTRLVV 1408
C ++ RL V
Sbjct: 1039 HCPLVVQARLCV 1050
Score = 35.8 bits (81), Expect = 0.42
Identities = 12/31 (38%), Positives = 18/31 (58%)
Query: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRP 618
+G WG W + +CS+ CG G++ R C P
Sbjct: 44 EGVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 31.6 bits (70), Expect = 7.9
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 7/53 (13%)
Query: 1506 WSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDC-----QGPR 1553
W+ CS CG GVQ+R CQ+ T ++ P RP + QGPR
Sbjct: 53 WASCSQPCGVGVQRRSRTCQLPTVQLHPSLPLPP--RPPRHPEALLPRGQGPR 103
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 253 bits (647), Expect = 1e-66
Identities = 223/870 (25%), Positives = 342/870 (39%), Gaps = 187/870 (21%)
Query: 588 DGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCLKQKR 647
DG W +W P+ CSRTCGGG ++R C K C GR +++++C+ C +
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCL------SSKSCEGRNIRYRTCSNVDCPPEAG 86
Query: 648 DFRDEQC-AHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVI 706
DFR +QC AH D KH W+P + + C L C+ G T +L +V+
Sbjct: 87 DFRAQQCSAHNDVKHHG-----QFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVL 139
Query: 707 DGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTFN---TVH 763
DGT C ++ D+C+ GLC+ GCDH L S + D CGVC GD S+C+ V G + +
Sbjct: 140 DGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSAT 199
Query: 764 YGYNTVVRIPAGATNIDVRQHSFSGETDDDNYL---ALSSSKGEFLLN--GNFVVTMAKR 818
+TVV IP G+ +I + + D YL L +KGE L+ G F+V
Sbjct: 200 KSDDTVVAIPYGSRHIRLVL-----KGPDHLYLETKTLQGTKGENSLSSTGTFLV----- 249
Query: 819 EIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQ 878
N+ V++ E + + + ++++ + G + V++ F PI +
Sbjct: 250 ----DNSSVDFQKFPDK-EILRMAGPLTADFIVKIRNSGSA-DSTVQFIFYQPIIHR--- 300
Query: 879 FYWNSHGPWQACSKPC-QGERKRKLVCTRESDQLTVSDQRCDRLPQ---PGHITEPCGTD 934
W + CS C G + C V+DQ C P+ P + C D
Sbjct: 301 --WR-ETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
Query: 935 -------------CDL-----RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVD 976
DL RW + CS+ CG G ++ + C + + G V+
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVE-EDIQGHVTSVE 416
Query: 977 DGFCSSHPKPSNREKCS-GECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDS 1035
+ C PK + C+ +C W W+ C+ +C G + R +C++ R +
Sbjct: 417 EWKCMYTPKMPIAQPCNIFDCPK--WLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTG 472
Query: 1036 KCTHQEKVTIQRCSEFPCPQWKSGD---------------------------------WS 1062
C+ + K I+ P P +K + WS
Sbjct: 473 GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWS 532
Query: 1063 ECLVTCGKGHKHRQVWCQ----FGEDRLNDRMCDPE-TKPTSMQTCQQPECA-------- 1109
C VTCG G + R V CQ F + + + + E KP S + C C+
Sbjct: 533 ACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNP 592
Query: 1110 -----------------SWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAAT 1152
W+ + +CS +CG G Q V C+ ++N C +
Sbjct: 593 DETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSR 652
Query: 1153 RPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSC--- 1209
RP L SC+ P +W G W+PCS TCG G + R V C
Sbjct: 653 RPPQL----LKSCNLDPCP------------ARWEIGKWSPCSLTCGVGLQTRDVFCSHL 696
Query: 1210 --RDENGSVADESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCV 1266
R+ N +V P+P + C+ C W W CS TCG G R+V+C
Sbjct: 697 LSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLC- 755
Query: 1267 NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHV 1326
+ D S + +PET S C Q +D P
Sbjct: 756 --KQRMADGSFLE---LPETFCSASKPACQQAC-----------KKDDCP---------- 789
Query: 1327 LGGNQWRTGPWGACSSTCAGGSQRRVVVCQ 1356
++W W CS++C G+Q R +C+
Sbjct: 790 ---SEWLLSDWTECSTSCGEGTQTRSAICR 816
Score = 229 bits (583), Expect = 3e-59
Identities = 157/534 (29%), Positives = 238/534 (44%), Gaps = 69/534 (12%)
Query: 1105 QPECASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDC-----NAATRPTDTQD 1159
QP W+ + CS TCG GYQL + +C VV D C N +P Q+
Sbjct: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPK-LQE 353
Query: 1160 CELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEN--GSVA 1217
C L C + P +W WT CS++CG G + R VSC +E+ G V
Sbjct: 354 CNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVT 413
Query: 1218 --DESACATLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDR 1275
+E C P+ + C++ C +W A +WS C+VTCGQG R V+C+++ +
Sbjct: 414 SVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHT 471
Query: 1276 SECDQDYIPETDQDCSMSPCPQRTPDSGL---AQHPFQNEDYRPRSASPSRTHVLGGNQW 1332
C P ++C + P P P L A+ P+ ++ V +
Sbjct: 472 GGCSPKTKPHIKEEC-IVPTPCYKPKEKLPVEAKLPW----FKQAQELEEGAAVSEEPSF 526
Query: 1333 RTGPWGACSSTCAGGSQRRVVVCQDENGYTAN------DCVERIKPDEQRACESGPCP-- 1384
W AC+ TC G+Q R+V CQ ++ + D E KP QRAC +GPC
Sbjct: 527 IPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGE 586
Query: 1385 -----------------------QWAYGNWGECTKLCGGGIRTRLVVC-QRSNGERFPDL 1420
W Y + +C++ CGGG++ +V C + E +
Sbjct: 587 IPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEEN 646
Query: 1421 SCEILDKPPD-REQCNTHACPHDAAWSTGPWSSCSVSCGRGHKQRNVYC---MAKDGSH- 1475
C +PP + CN CP A W G WS CS++CG G + R+V+C ++++ +
Sbjct: 647 LCVTSRRPPQLLKSCNLDPCP--ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET 704
Query: 1476 --LESDYCKHLAKPHGHRKCRGGRC-PKWKAGAWSQCSVSCGRGVQQRHVGCQ----IGT 1528
L + C+ KP + C C P W W CS +CG GVQ+R V C+ G+
Sbjct: 705 VILADELCRQ-PKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGS 763
Query: 1529 HKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVC 1582
ET C+ ++P ++ C+ CP W +W EC+ +CGEG++ R +C
Sbjct: 764 FLELPETFCSA-SKPACQQACKKDDCP-SEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 200 bits (509), Expect = 1e-50
Identities = 152/559 (27%), Positives = 221/559 (39%), Gaps = 126/559 (22%)
Query: 938 RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECN 997
RW CSA CG GY+ C Y + V D +C +P+ + ECN
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAEC--YDLRSNRV--VADQYCHYYPENIKPKPKLQECN 355
Query: 998 TGG---------------------WRYSAWTECSKSCDGGTQRRRAICVNTRNDV----- 1031
W + WT CS SC GG Q R CV D+
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVE--EDIQGHVT 413
Query: 1032 -LDDSKCTHQEKVTI-QRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDR 1089
+++ KC + K+ I Q C+ F CP+W + +WS C VTCG+G ++R V C ++
Sbjct: 414 SVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLC-IDHRGMHTG 472
Query: 1090 MCDPETKPTSMQTCQQP--------------------------------ECASWQAGPWG 1117
C P+TKP + C P E S+ W
Sbjct: 473 GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWS 532
Query: 1118 QCSVTCGQGYQLRAVKC--IIGTYMSVVD--DNDCNAATRPTDTQDCELPSCHP--PPAA 1171
C+VTCG G Q+R V+C ++ SV D ++C +P + C C P
Sbjct: 533 ACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGP-KPASQRACYAGPCSGEIPEFN 591
Query: 1172 PETRRSTYSAPRT-----QWRFGSWTPCSATCGKGTRMRYVSCRD-ENGSVADESACATL 1225
P+ + + W + +T CS +CG G + VSC + + A+E+ C T
Sbjct: 592 PDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTS 651
Query: 1226 PRPVAK-EECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNY-----SDHVIDRSEC 1278
RP + C++ PC +W+ WS CS+TCG G TR V C + ++ VI E
Sbjct: 652 RRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADEL 711
Query: 1279 DQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWG 1338
+ P T Q C+ CP W W
Sbjct: 712 CRQPKPSTVQACNRFNCPPA---------------------------------WYPAQWQ 738
Query: 1339 ACSSTCAGGSQRRVVVCQDENGYTA-----NDCVERIKPDEQRACESGPCP-QWAYGNWG 1392
CS TC GG Q+R V+C+ + KP Q+AC+ CP +W +W
Sbjct: 739 PCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWT 798
Query: 1393 ECTKLCGGGIRTRLVVCQR 1411
EC+ CG G +TR +C++
Sbjct: 799 ECSTSCGEGTQTRSAICRK 817
Score = 194 bits (492), Expect = 9e-49
Identities = 202/840 (24%), Positives = 291/840 (34%), Gaps = 168/840 (20%)
Query: 987 SNREKCSGECNTGGW-RYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTI 1045
S+R S E G W + W+ECS++C GG C++ SK +
Sbjct: 22 SSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLS--------SKSCEGRNIRY 73
Query: 1046 QRCSEFPCPQWKSGDWSECLVTCGKGHKHR---QVWCQFGEDRLNDRMCDPETKPTSMQT 1102
+ CS CP ++GD+ + KH W D N + K T++
Sbjct: 74 RTCSNVDCPP-EAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVV 132
Query: 1103 CQQPE--------------CASWQAGPWG------------QCSVTCGQGYQLRAVKCII 1136
P+ C S G C V G G R V+
Sbjct: 133 ELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQY 192
Query: 1137 GTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRR-------------STYSAPR 1183
+ +S +D A P ++ L P ET+ T+
Sbjct: 193 KSQLSATKSDDTVVAI-PYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDN 251
Query: 1184 TQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECSVTPCGQWK 1243
+ F + G + N AD + +P+ +W+
Sbjct: 252 SSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIH---------RWR 302
Query: 1244 ALDWSSCSVTCGQGRATRQVMCVNY-SDHVIDRSECDQDYIPETD------QDCSMSPCP 1296
D+ CS TCG G C + S+ V+ C Y PE Q+C++ PCP
Sbjct: 303 ETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCH--YYPENIKPKPKLQECNLDPCP 360
Query: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ 1356
D P+ PR W PW ACSS+C GG Q R V C
Sbjct: 361 --ASDGYKQIMPYDLYHPLPR--------------WEATPWTACSSSCGGGIQSRAVSCV 404
Query: 1357 DEN--GYTAN----DCVERIKPDEQRACESGPCPQWAYGNWGECTKLCGGGIRTRLVVCQ 1410
+E+ G+ + C+ K + C CP+W W CT CG G+R R+V+C
Sbjct: 405 EEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCI 464
Query: 1411 RSNGERFPDLSCEILDKPPDREQC-----------------------NTHACPHDAAWST 1447
G C KP +E+C AA S
Sbjct: 465 DHRGMHTG--GCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSE 522
Query: 1448 GP------WSSCSVSCGRGHKQRNVYCM-----AKDGSHLESDYCKHLAKPHGHRKCRGG 1496
P WS+C+V+CG G + R V C ++ + L D C+ KP R C G
Sbjct: 523 EPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPASQRACYAG 581
Query: 1497 RCP-------------------------KWKAGAWSQCSVSCGRGVQQRHVGC-QIGTHK 1530
C W+ +++CS SCG GVQ+ V C T +
Sbjct: 582 PCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE 641
Query: 1531 IARETECNPYTRP-ESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCV-----D 1584
A E C RP + + C CP W +W C+ TCG G + R V C +
Sbjct: 642 PAEENLCVTSRRPPQLLKSCNLDPCPA-RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSRE 700
Query: 1585 DNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYT 1644
N+ + +P ++C+ C W +W CS TCG G ++R V C +
Sbjct: 701 MNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMA 760
Query: 1645 GKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQC 1704
E C ++P C DCP + W + +W CS SCG G RS C
Sbjct: 761 DGSFLELPETF---CSASKPACQQACKKDDCP--SEWLLSDWTECSTSCGEGTQTRSAIC 815
Score = 190 bits (483), Expect = 1e-47
Identities = 156/592 (26%), Positives = 229/592 (38%), Gaps = 143/592 (24%)
Query: 1185 QWRFGSWTPCSATCGKGTRMRYVSCRD--ENGSVADESACATLP---RPVAK-EECSVTP 1238
+WR + PCSATCG G ++ C D N VAD+ C P +P K +EC++ P
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQY-CHYYPENIKPKPKLQECNLDP 358
Query: 1239 CG------------------QWKALDWSSCSVTCGQGRATRQVMCV--NYSDHVIDRSEC 1278
C +W+A W++CS +CG G +R V CV + HV E
Sbjct: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 1279 DQDYIPETD--QDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGP 1336
Y P+ Q C++ CP+ W
Sbjct: 419 KCMYTPKMPIAQPCNIFDCPK----------------------------------WLAQE 444
Query: 1337 WGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRAC-ESGPC------------ 1383
W C+ TC G + RVV+C D G C + KP + C PC
Sbjct: 445 WSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAK 504
Query: 1384 -------------------PQWAYGNWGECTKLCGGGIRTRLVVCQ--RSNGERFPDLSC 1422
P + W CT CG G + R+V CQ S + DL
Sbjct: 505 LPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPI 564
Query: 1423 EILD--KPPDREQCNTHACPHDAA----------------------WSTGPWSSCSVSCG 1458
+ + KP + C C + W ++ CS SCG
Sbjct: 565 DECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCG 624
Query: 1459 RGHKQRNVYCMAKDGSH-LESDYCKHLAKPHGHRK-CRGGRCP-KWKAGAWSQCSVSCGR 1515
G ++ V C+ K E + C +P K C CP +W+ G WS CS++CG
Sbjct: 625 GGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGV 684
Query: 1516 GVQQRHVGCQIGTHKIARET--------ECNPYTRPESERDCQGPRCPLYTWRAEEWQEC 1567
G+Q R V C +H ++RE E +P + + C CP W +WQ C
Sbjct: 685 GLQTRDVFC---SHLLSREMNETVILADELCRQPKPSTVQACNRFNCPP-AWYPAQWQPC 740
Query: 1568 TKTCGEGSRYRKVVC----VDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSE 1623
++TCG G + R+V+C D + E+ C SK P +++C C W+ +W+E
Sbjct: 741 SRTCGGGVQKREVLCKQRMADGSFLELPETFCSASK-PACQQACKKDDCPSEWLLSDWTE 799
Query: 1624 CSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675
CS +CG+G + R C ++ K +T+ P S+ PC L C
Sbjct: 800 CSTSCGEGTQTRSAICRKML--KTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
Score = 129 bits (324), Expect = 3e-29
Identities = 118/477 (24%), Positives = 192/477 (40%), Gaps = 109/477 (22%)
Query: 845 IEQELLLQVLSVGK---LYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPC-QGERKR 900
+E+++ V SV + +Y P + + I D P+ W + W C+ C QG R R
Sbjct: 404 VEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPK---WLAQ-EWSPCTVTCGQGLRYR 459
Query: 901 KLVCTRESDQLTVSDQRCDRLPQPGHITEPC-------------GTDCDLRWHVASR--- 944
++C D + C +P HI E C + L W ++
Sbjct: 460 VVLCI---DHRGMHTGGCSPKTKP-HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELE 515
Query: 945 ----------------SECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN 988
S C+ CG+G + + C + C PKP++
Sbjct: 516 EGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEG-PKPAS 574
Query: 989 REKC-SGECNT--------------GG---------WRYSAWTECSKSCDGGTQRRRAIC 1024
+ C +G C+ GG W Y +T+CS+SC GG Q C
Sbjct: 575 QRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSC 634
Query: 1025 VNTRN-DVLDDSKCTHQEKVT--IQRCSEFPCP-QWKSGDWSECLVTCGKGHKHRQVWCQ 1080
+N + + +++ C + ++ C+ PCP +W+ G WS C +TCG G + R V+C
Sbjct: 635 LNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCS 694
Query: 1081 FGEDR-------LNDRMCDPETKPTSMQTCQQPECA-SWQAGPWGQCSVTCGQGYQLRAV 1132
R L D +C + KP+++Q C + C +W W CS TCG G Q R V
Sbjct: 695 HLLSREMNETVILADELCR-QPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREV 753
Query: 1133 KC----IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRF 1188
C G+++ + + C+A+ +P Q C+ C ++W
Sbjct: 754 LCKQRMADGSFLEL-PETFCSAS-KPACQQACKKDDCP-----------------SEWLL 794
Query: 1189 GSWTPCSATCGKGTRMRYVSCRD--ENG--SVADESACATLPRPVAKEECSVTPCGQ 1241
WT CS +CG+GT+ R CR + G +V + + C LP + C + C +
Sbjct: 795 SDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCAR 851
Score = 119 bits (298), Expect = 3e-26
Identities = 98/372 (26%), Positives = 142/372 (38%), Gaps = 89/372 (23%)
Query: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESD-YCKHLA---KPHGH-RKCRGGRCP 1499
W + CS +CG G++ + C + + +D YC + KP ++C CP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1500 ------------------KWKAGAWSQCSVSCGRGVQQRHVGC---QIGTHKIA-RETEC 1537
+W+A W+ CS SCG G+Q R V C I H + E +C
Sbjct: 361 ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC 420
Query: 1538 NPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDV 1597
+ + C CP W A+EW CT TCG+G RYR V+C+D +H C
Sbjct: 421 MYTPKMPIAQPCNIFDCP--KWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSP 476
Query: 1598 SKRPVDRESCSLQ-PC------------------------------EYVWITGEWSECSV 1626
+P +E C + PC E +I WS C+V
Sbjct: 477 KTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTV 536
Query: 1627 TCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCY--------------- 1671
TCG G + R+V C + + ++ + C G +P S CY
Sbjct: 537 TCGVGTQVRIVRCQVLLSFSQSV--ADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDE 594
Query: 1672 -------LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL---TNEDQPSHLCHTDLKP 1721
L+D W + CS SCG GV + V CL T E +LC T +P
Sbjct: 595 TDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRP 654
Query: 1722 EERKTCRNVYNC 1733
+ N+ C
Sbjct: 655 PQLLKSCNLDPC 666
Score = 115 bits (289), Expect = 3e-25
Identities = 70/238 (29%), Positives = 106/238 (44%), Gaps = 18/238 (7%)
Query: 1332 WRTGPWGACSSTCA--GGSQRRVVVCQDENGYTANDCVERIKPDEQR-ACESGPCP-QWA 1387
W CS++C G Q R+ + C +++P Q AC CP +W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 1388 YGNWGECTKLCGGGIRTRLVVCQR--SNGERFP---DLSCEILDKPPDREQCNTHACPHD 1442
+W CT+ CGGG++TR V CQ+ ++G P D+ ++ +P D + CN C
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC--- 1607
Query: 1443 AAWSTGPWSSCSVSCGRGH---KQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCP 1499
W+ W C+ C H + R V+C +DG L S+ C L +P + C C
Sbjct: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACS 1667
Query: 1500 -KWKAGAWSQCSVSCGR-GVQQRHVGC-QIGTHKIARETECNPYTRPESERDCQGPRC 1554
W+ W+ C+ +CG G Q R V C T+K E C+ RP + + C C
Sbjct: 1668 VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
Score = 113 bits (283), Expect = 2e-24
Identities = 78/285 (27%), Positives = 117/285 (41%), Gaps = 31/285 (10%)
Query: 936 DLRWHVASRSECSAQCG-LGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPS------N 988
D W V + CSA CG G + + C S +V+ C+ +P+ N
Sbjct: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLNST------EVNPAHCAGKVRPAVQPIACN 1541
Query: 989 REKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTR----NDVLDDSKCTHQEK-- 1042
R C W ++W+ C++SC GG Q RR C + + + + CT K
Sbjct: 1542 RRDCPSR-----WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRP 1596
Query: 1043 VTIQRCSEFPCPQWKSGDWSECLVTCGKGH---KHRQVWCQFGED-RLNDRMCDPETKPT 1098
V Q C++ C +W W +C C H +HRQV+CQ + L C +P
Sbjct: 1597 VDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPV 1656
Query: 1099 SMQTCQQPECA-SWQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNAATRPTD 1156
S Q C C+ W+ W C+ TCG G+Q R V+C+ V ++ C+ RP +
Sbjct: 1657 STQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPAN 1716
Query: 1157 TQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSW-TPCSATCGK 1200
Q C + C TR + + + C TCGK
Sbjct: 1717 WQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
Score = 107 bits (268), Expect = 9e-23
Identities = 74/261 (28%), Positives = 103/261 (39%), Gaps = 34/261 (13%)
Query: 1001 WRYSAWTECSKSCDG-GTQRRRAICVNTRNDVLDDSKCTHQEKVTIQ--RCSEFPCP-QW 1056
W CS SC G Q+ R C+ +V + + C + + +Q C+ CP +W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEV-NPAHCAGKVRPAVQPIACNRRDCPSRW 1549
Query: 1057 KSGDWSECLVTCGKGHKHRQVWCQ------FGEDRLNDRMCDPETKPTSMQTCQQPECAS 1110
WS C +CG G + R+V CQ ND +P Q C Q C
Sbjct: 1550 MVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVE 1609
Query: 1111 WQAGPWGQCSVTC---GQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHP 1167
W WGQC+ C Q R V C +++ + C+A RP TQ+C +C
Sbjct: 1610 WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSE-QCSALPRPVSTQNCWSEAC-- 1666
Query: 1168 PPAAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSC-RDENGSVADESACATL 1225
WR WT C+ATCG G + R V C E C+
Sbjct: 1667 ---------------SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWG 1711
Query: 1226 PRPVAKEECSVTPCGQWKALD 1246
PRP + C++TPC + D
Sbjct: 1712 PRPANWQRCNITPCENMECRD 1732
Score = 105 bits (262), Expect = 4e-22
Identities = 68/253 (26%), Positives = 102/253 (40%), Gaps = 31/253 (12%)
Query: 1056 WKSGDWSECLVTCG-KGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQ-TCQQPECAS-WQ 1112
W + C +CG +G + ++ C +N C + +P C + +C S W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 1113 AGPWGQCSVTCGQGYQLRAVKC----IIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
W C+ +CG G Q R V C G V +D A RP DTQ C C
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC--- 1607
Query: 1169 PAAPETRRSTYSAPRTQWRFGSWTPCSATC---GKGTRMRYVSCRDENGSVADESACATL 1225
+W F SW C+ C + R V C+ +G C+ L
Sbjct: 1608 ---------------VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSAL 1652
Query: 1226 PRPVAKEECSVTPCG-QWKALDWSSCSVTCGQ-GRATRQVMCVN-YSDHVIDRSECDQDY 1282
PRPV+ + C C W+ W+ C+ TCG G +R+V CV+ ++ + C
Sbjct: 1653 PRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGP 1712
Query: 1283 IPETDQDCSMSPC 1295
P Q C+++PC
Sbjct: 1713 RPANWQRCNITPC 1725
Score = 105 bits (261), Expect = 6e-22
Identities = 79/266 (29%), Positives = 114/266 (42%), Gaps = 32/266 (12%)
Query: 1501 WKAGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESER-DCQGPRCPLYT 1558
W + CS SCG RGVQQ + C + + ++ C RP + C CP
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEV-NPAHCAGKVRPAVQPIACNRRDCPS-R 1548
Query: 1559 WRAEEWQECTKTCGEGSRYRKVVC----VDDNKNEVHGARC-DVSKRPVDRESCSLQPCE 1613
W W CT++CG G + R+V C V C V+KRPVD ++C+ Q C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC- 1607
Query: 1614 YVWITGEWSECSVTC---GKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
W W +C+ C + R V C ++ + P +P S C
Sbjct: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQT----RDGITLPSEQCSALP--RPVSTQNC 1661
Query: 1671 YLRDCPVSATWRVGNWGSCSVSCG-VGVMQRSVQCL---TNEDQPSHLCHTDLKPEERKT 1726
+ C V WRV W C+ +CG G R V+C+ TN+ P HLC +P +
Sbjct: 1662 WSEACSVH--WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQR 1719
Query: 1727 CRNVYNCE------LPQNCKEVKRLK 1746
C N+ CE + C++VK+LK
Sbjct: 1720 C-NITPCENMECRDTTRYCEKVKQLK 1744
Score = 95.5 bits (236), Expect = 4e-19
Identities = 73/300 (24%), Positives = 117/300 (39%), Gaps = 51/300 (17%)
Query: 1214 GSVADESACATLPRPVAKEECSVTPCGQWKALD-WSSCSVTCG-QGRATRQVMCVNYSDH 1271
GS + S A V ++ S+ W ++D ++CS +CG +G ++ C+ S
Sbjct: 1462 GSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE 1521
Query: 1272 VIDRSECDQDYIPETDQ-DCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGN 1330
V + + C P C+ CP R
Sbjct: 1522 V-NPAHCAGKVRPAVQPIACNRRDCPSR-------------------------------- 1548
Query: 1331 QWRTGPWGACSSTCAGGSQRRVVVCQDENGY-----TANDCVERI--KPDEQRACESGPC 1383
W W AC+ +C GG Q R V CQ +ND ++ +P + +AC C
Sbjct: 1549 -WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC 1607
Query: 1384 PQWAYGNWGECTKLCGG---GIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440
+WA+ +WG+C C G ++ R V CQ +G P C L +P + C + AC
Sbjct: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC- 1666
Query: 1441 HDAAWSTGPWSSCSVSCGR-GHKQRNVYCM-AKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498
W W+ C+ +CG G + R V C+ A+ + C +P ++C C
Sbjct: 1667 -SVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
Score = 94.7 bits (234), Expect = 8e-19
Identities = 67/247 (27%), Positives = 102/247 (41%), Gaps = 17/247 (6%)
Query: 1442 DAAWSTGPWSSCSVSCG-RGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHR-KCRGGRCP 1499
D WS ++CS SCG RG +Q + C+ + + + +C +P C CP
Sbjct: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLL-NSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 1500 -KWKAGAWSQCSVSCGRGVQQRHVGCQ------IGTHKIARETECNPYTRPESERDCQGP 1552
+W +WS C+ SCG GVQ R V CQ I T ++ + RP + C
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGIST-PVSNDMCTQVAKRPVDTQACNQQ 1605
Query: 1553 RCPLYTWRAEEWQECTKTC---GEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
C W W +C C ++R+V C + + +C RPV ++C
Sbjct: 1606 LC--VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWS 1663
Query: 1610 QPCEYVWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVH 1668
+ C W W+ C+ TCG G++ R V C T K E+ Q ++
Sbjct: 1664 EACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNIT 1723
Query: 1669 PCYLRDC 1675
PC +C
Sbjct: 1724 PCENMEC 1730
Score = 84.3 bits (207), Expect = 1e-15
Identities = 66/247 (26%), Positives = 104/247 (42%), Gaps = 16/247 (6%)
Query: 878 QFYWNSHGPWQACSKPC--QGERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPCGT-D 934
Q YW S CS C +G ++ +L C S + V+ C +P C D
Sbjct: 1487 QDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRD 1544
Query: 935 CDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPK-PSNREKCS 993
C RW V S S C+ CG G +T + C K + G + V + C+ K P + + C+
Sbjct: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKL-KASGISTPVSNDMCTQVAKRPVDTQACN 1603
Query: 994 GECNTGGWRYSAWTECSKSCDG---GTQRRRAICVNTRNDVLDDSKCTHQEK-VTIQRC- 1048
+ W +S+W +C+ C G Q R+ C L +C+ + V+ Q C
Sbjct: 1604 QQLCV-EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCW 1662
Query: 1049 SEFPCPQWKSGDWSECLVTCGK-GHKHRQVWCQFGEDR--LNDRMCDPETKPTSMQTCQQ 1105
SE W+ W+ C TCG G + R+V C + + +C +P + Q C
Sbjct: 1663 SEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNI 1722
Query: 1106 PECASWQ 1112
C + +
Sbjct: 1723 TPCENME 1729
Score = 80.1 bits (196), Expect = 2e-14
Identities = 55/210 (26%), Positives = 82/210 (39%), Gaps = 39/210 (18%)
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEV------HGARCDVSKRPVDRESCSL 1609
++ WR ++ C+ TCG G + C D N V H ++ +P +E C+L
Sbjct: 298 IHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNL 356
Query: 1610 QPCEYV-----------------WITGEWSECSVTCGKGYKQRLVSCSEI-----YTGKE 1647
PC W W+ CS +CG G + R VSC E T E
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 1648 NYEYSYQTTINCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTN 1707
++ Y + P PC + DCP W W C+V+CG G+ R V C+ +
Sbjct: 417 EWKCMYTPKM-------PIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCIDH 466
Query: 1708 EDQPSHLCHTDLKPEERKTCRNVYNCELPQ 1737
+ C KP ++ C C P+
Sbjct: 467 RGMHTGGCSPKTKPHIKEECIVPTPCYKPK 496
Score = 71.6 bits (174), Expect = 7e-12
Identities = 53/213 (24%), Positives = 88/213 (41%), Gaps = 34/213 (15%)
Query: 887 WQACSKPCQGE-RKRKLVCTR---ESDQLTVSDQRCDRLPQPGHITEPCGTDCDLRWHVA 942
W AC++ C G + R++ C + VS+ C ++ + T+ C + W +
Sbjct: 1554 WSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFS 1613
Query: 943 SRSECSAQC---GLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTG 999
S +C+ C L + ++C + +E+ CS+ P+P + + C E +
Sbjct: 1614 SWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQ-----CSALPRPVSTQNCWSEACSV 1668
Query: 1000 GWRYSAWTECSKSCDG-GTQRRRAICVNTR-NDVLDDSKCTHQEK-VTIQRCSEFPCPQW 1056
WR S WT C+ +C G Q RR CV+ R N + + C+ + QRC+ PC
Sbjct: 1669 HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENM 1728
Query: 1057 KSGDW-------------------SECLVTCGK 1070
+ D S C TCGK
Sbjct: 1729 ECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGK 1761
Score = 55.1 bits (131), Expect = 7e-07
Identities = 34/123 (27%), Positives = 50/123 (40%), Gaps = 23/123 (18%)
Query: 1610 QPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGK---ENYEYSYQTTINCPGTQPPS 1666
QP + W ++ CS TCG GY+ C ++ + + + Y + Y I P
Sbjct: 295 QPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIK----PKPK 350
Query: 1667 VHPCYLRDCPVS---------------ATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQP 1711
+ C L CP S W W +CS SCG G+ R+V C+ ED
Sbjct: 351 LQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCV-EEDIQ 409
Query: 1712 SHL 1714
H+
Sbjct: 410 GHV 412
Score = 53.9 bits (128), Expect = 1e-06
Identities = 33/103 (32%), Positives = 47/103 (45%), Gaps = 13/103 (12%)
Query: 1605 ESCSLQPCEYVWITGEWSECSVTCG-KGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQ 1663
+ SL +Y W + CS +CG +G +Q + C + +C G
Sbjct: 1480 QKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCL--------LNSTEVNPAHCAGKV 1531
Query: 1664 PPSVHP--CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQC 1704
P+V P C RDCP + W V +W +C+ SCG GV R V C
Sbjct: 1532 RPAVQPIACNRRDCP--SRWMVTSWSACTRSCGGGVQTRRVTC 1572
Score = 38.1 bits (87), Expect = 0.084
Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 23/101 (22%)
Query: 565 ECEPGKHCKYGFCV--PKEMDVPV-----TDGSWGS-----------WSPFGTCSRTCGG 606
ECE K C P ++P TDG +G + F CS +CGG
Sbjct: 566 ECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG 625
Query: 607 GIKTAIRECNRPEPKNGGK--YCVGRR---MKFKSCNTEPC 642
G++ A+ C + + + CV R KSCN +PC
Sbjct: 626 GVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPC 666
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 231 bits (589), Expect = 5e-60
Identities = 166/539 (30%), Positives = 261/539 (48%), Gaps = 63/539 (11%)
Query: 46 SEYEIVSPIRVNALGEPFPTNVHFKRTR---RSINSATDPWPAFASSSSSSTSSQAHYRL 102
+E + P+R +A G V +R R+ +A P+F + S Y +
Sbjct: 54 AERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNV 113
Query: 103 SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEH 162
+ FG+ L NA +AP T+ G G + E L C Y G V +E
Sbjct: 114 TVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV------EPLLGSCLYVGDVAGLAEA 167
Query: 163 TAV-ISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRH 221
++V +S C G+ G R + ++FIEPL+ E EQ + H++YRR P P G
Sbjct: 168 SSVALSNCDGLAGLIRMEEEEFFIEPLEK-GLAAQEAEQGRVHVVYRRP-PTSPPLGGPQ 225
Query: 222 ACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRT 281
A DT S D + +R G + N +
Sbjct: 226 ALDTGA-----SLDSLDSLSRALG-------------------VLEEHANSS-------- 253
Query: 282 HRRTKRFLSYPRF-VEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLINI 339
RR +R + + +EVL+ D+ +V +HG E++Q Y+LTLM+IV IY D S+G IN+
Sbjct: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
Query: 340 VIVNLIVIHNEQDGPSISF-NAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLTRQDICR 395
V+V +I++ + I N +L+N C+W + + P H HD A+ LTRQD
Sbjct: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
Query: 396 AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEG 454
G A + +C P RSC+++ + G S+AF +AHE GHV M HD N+C +E
Sbjct: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE- 428
Query: 455 VKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGIL 514
+MAP + + + WS+CS++ ++ +L + +CLL++P + +P QLPG+
Sbjct: 429 -VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLH 485
Query: 515 YNVNKQCELIFGPGSQVCPYMM---QCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGK 570
Y++N+QC FG G +C C++LWC++ + + C+T+ P DGT C PGK
Sbjct: 486 YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY-FCKTKKGPPLDGTMCAPGK 543
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 196 bits (497), Expect = 2e-49
Identities = 110/352 (31%), Positives = 160/352 (45%), Gaps = 25/352 (7%)
Query: 1385 QWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP-PDREQCNTHACPHDA 1443
+W + C+ C G+ + +C R +G D C+ L +P P E C C
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC--QP 624
Query: 1444 AWSTGPWSSCSVSCGRGHKQRNVYC--MAKDG--SHLESDYCK--HLAKPHGHRKCRGGR 1497
W T WS CS +CG G++ R V C M G S + SD C+ +P + CR
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 1498 C-PKWKAGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
C P+W+ WS+C+ CG R V R + C E C+P TRP E++C GP C
Sbjct: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCS------EDEKLCDPNTRPVGEKNCTGPPCD 738
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
W +W C+ +CG+G R V C + V ++C + +P+ C + C
Sbjct: 739 RQ-WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675
W+ +W C+ TCG+G K+RLV C E+ GK + + +PP C+ R C
Sbjct: 798 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKKPPEESTCFERPC 854
Query: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
W W C+ +CGVGV R V+C D C +KP R+ C
Sbjct: 855 ---FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQAC 902
Score = 193 bits (491), Expect = 1e-48
Identities = 129/403 (32%), Positives = 170/403 (42%), Gaps = 64/403 (15%)
Query: 1227 RPVAKEECSVTPCG--QWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
RP A+++ V+P +WK CS TC G + MCV Y +D S CD P
Sbjct: 552 RPKARKQ-GVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 610
Query: 1285 ETDQD-CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSST 1343
E + C+ C R W T W CS T
Sbjct: 611 EPVHEFCAGRECQPR---------------------------------WETSSWSECSRT 637
Query: 1344 CAGGSQRRVVVCQ-------DENGYT-ANDCVERIKPDEQRACESGPC-PQWAYGNWGEC 1394
C G Q RVV C D + Y+ + E ++P+E++ C + C PQW W EC
Sbjct: 638 CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 697
Query: 1395 TKLCGG-GIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSC 1453
T CG + TR + C S E+ C+ +P + C C D W+ W C
Sbjct: 698 TAKCGERSVVTRDIRC--SEDEKL----CDPNTRPVGEKNCTGPPC--DRQWTVSDWGPC 749
Query: 1454 SVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVS 1512
S SCG+G R+VYC DG + C+ KP C CP W A W +C+ +
Sbjct: 750 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT 809
Query: 1513 CGRGVQQRHVGCQI---GTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTK 1569
CGRGV++R V C G + EC +P E C C + W W ECTK
Sbjct: 810 CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPWSECTK 867
Query: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
TCG G R R V C + V G CD +PV R++C LQPC
Sbjct: 868 TCGVGVRMRDVKCYQGT-DIVRG--CDPLVKPVGRQACDLQPC 907
Score = 190 bits (482), Expect = 1e-47
Identities = 128/440 (29%), Positives = 180/440 (40%), Gaps = 79/440 (17%)
Query: 1036 KCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLNDRMCDPE 1094
K + K Q S +WK C TC G C ++ ++D CD
Sbjct: 548 KARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDAL 607
Query: 1095 TKPTSM-QTCQQPECAS-WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCN 1149
T+P + + C EC W+ W +CS TCG+GYQ R V+C + + S V + C
Sbjct: 608 TRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCE 667
Query: 1150 AA--TRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYV 1207
AA RP + + C P+C P QW W+ C+A CG+ R V
Sbjct: 668 AAEAVRPEERKTCRNPACGP-----------------QWEMSEWSECTAKCGE----RSV 706
Query: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCV 1266
RD S DE C RPV ++ C+ PC QW DW CS +CGQGR R V C
Sbjct: 707 VTRDIRCS-EDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCK 765
Query: 1267 NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHV 1326
V+ S+C + P C CP
Sbjct: 766 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH---------------------------- 797
Query: 1327 LGGNQWRTGPWGACSSTCAGGSQRRVVVCQD-ENGY----TANDCVERIKPDEQRACESG 1381
W W C++TC G ++R+V+C + NG + +C KP E+ C
Sbjct: 798 -----WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFER 852
Query: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDL--SCEILDKPPDREQCNTHAC 1439
PC +W W ECTK CG G+R R V C + D+ C+ L KP R+ C+ C
Sbjct: 853 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGT-----DIVRGCDPLVKPVGRQACDLQPC 907
Query: 1440 ---PHDAAWSTGPWSSCSVS 1456
P D + P ++C+++
Sbjct: 908 PTEPPDDSCQDQPGTNCALA 927
Score = 188 bits (477), Expect = 5e-47
Identities = 121/388 (31%), Positives = 162/388 (41%), Gaps = 45/388 (11%)
Query: 938 RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN-REKCSGEC 996
RW ++S CSA C G + C +Y ++ VDD +C + +P E C+G
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-----VDDSYCDALTRPEPVHEFCAGRE 621
Query: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDS----KCTHQEKVTIQR---CS 1049
W S+W+ECS++C G Q R C + D S C E V + C
Sbjct: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
Query: 1050 EFPC-PQWKSGDWSECLVTCG-KGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPE 1107
C PQW+ +WSEC CG + R + C ED +++CDP T+P + C P
Sbjct: 682 NPACGPQWEMSEWSECTAKCGERSVVTRDIRC--SED---EKLCDPNTRPVGEKNCTGPP 736
Query: 1108 C-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCH 1166
C W WG CS +CGQG +R V C VV ++ C T+P C +C
Sbjct: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAIHPCGDKNC- 794
Query: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRD-ENGSVADESA--CA 1223
PA W W C+ TCG+G + R V C + NG S C
Sbjct: 795 --PA--------------HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
Query: 1224 TLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYI 1283
+P + C PC +W WS C+ TCG G R V C +D V CD
Sbjct: 839 LAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---RGCDPLVK 895
Query: 1284 PETDQDCSMSPCPQRTPDSGLAQHPFQN 1311
P Q C + PCP PD P N
Sbjct: 896 PVGRQACDLQPCPTEPPDDSCQDQPGTN 923
Score = 177 bits (450), Expect = 7e-44
Identities = 115/415 (27%), Positives = 174/415 (41%), Gaps = 73/415 (17%)
Query: 985 KPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKC---THQE 1041
+P R++ + W+ S+ CS +C G A+CV +DDS C T E
Sbjct: 552 RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPE 611
Query: 1042 KVTIQRCSEFPC-PQWKSGDWSECLVTCGKGHKHRQVWCQ------FGEDRLNDRMCDPE 1094
V + C+ C P+W++ WSEC TCG+G++ R V C F +D +C+
Sbjct: 612 PVH-EFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAA 669
Query: 1095 --TKPTSMQTCQQPECA-SWQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNA 1150
+P +TC+ P C W+ W +C+ CG+ R ++C D+ C+
Sbjct: 670 EAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCS-------EDEKLCDP 722
Query: 1151 ATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210
TRP ++C P C QW W PCS +CG+G +R+V C+
Sbjct: 723 NTRPVGEKNCTGPPCD-----------------RQWTVSDWGPCSGSCGQGRTIRHVYCK 765
Query: 1211 DENGSVADESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYS 1269
+G V ES C +P+A C C W A DW C+ TCG+G R V+C+ +
Sbjct: 766 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 825
Query: 1270 DHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
+ P + P+ GLA+ P + R
Sbjct: 826 NG---------------------KPQTRSGPECGLAKKPPEESTCFERPCF--------- 855
Query: 1330 NQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
+W T PW C+ TC G + R V C + C +KP ++AC+ PCP
Sbjct: 856 -KWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 908
Score = 150 bits (378), Expect = 2e-35
Identities = 99/309 (32%), Positives = 139/309 (44%), Gaps = 32/309 (10%)
Query: 591 WGSWSPFGTCSRTCGGGIKTAIREC----NRPEPKNGGKYCVGRRMKFKSCNTEPCLKQK 646
WG W+ + CSR+CGGG+ + R C + P G + C G +++ C + C
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 647 RDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGI---LMKDRCKLFCRVAGNTAYYQLRD 703
R FR+EQC F+ +N +W P Y + C L C +
Sbjct: 110 RSFREEQCVSFNSHVYNGR----THQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPA 165
Query: 704 RVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTF--N 760
R DGT C D +CV G C GCD VL S DKCG+C GD SSC V G +
Sbjct: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
Query: 761 TVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREI 820
H GY+ V IPAGA +I + + S + LAL+ G + NGN+ V K
Sbjct: 224 NAHLGYSLVTHIPAGARDIQIVERKKSADV-----LALADEAGYYFFNGNYKVDSPK-NF 277
Query: 821 RIGNAVVEYSGS----ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNI---PI 872
I VV+Y ET +E I + Q L + V + GK +P + + + + P
Sbjct: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGK--SPSITFEYTLLQPPH 335
Query: 873 EDKPQQFYW 881
E +PQ Y+
Sbjct: 336 ESRPQPIYY 344
Score = 143 bits (361), Expect = 1e-33
Identities = 108/381 (28%), Positives = 146/381 (38%), Gaps = 72/381 (18%)
Query: 882 NSHGPWQACSKPCQ-GERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPC-GTDCDLRW 939
+SH P CS C G +C R D + V D CD L +P + E C G +C RW
Sbjct: 571 SSHEP---CSATCTTGVMSAYAMCVRY-DGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 940 HVASRSECSAQCGLGYRTLDIYCAK----------YSRLDGKTEKV-------------- 975
+S SECS CG GY+ + C K YS L E V
Sbjct: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
Query: 976 -----------------------------DDGFCSSHPKPSNREKCSGECNTGGWRYSAW 1006
D+ C + +P + C+G W S W
Sbjct: 687 PQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDW 746
Query: 1007 TECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEK-VTIQRCSEFPCP-QWKSGDWSEC 1064
CS SC G R C + V+ +S+C + K + I C + CP W + DW C
Sbjct: 747 GPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERC 806
Query: 1065 LVTCGKGHKHRQVWC-QFGEDRLNDRM---CDPETKPTSMQTCQQPECASWQAGPWGQCS 1120
TCG+G K R V C + + R C KP TC + C W PW +C+
Sbjct: 807 NTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECT 866
Query: 1121 VTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC--HPPPAAPETRRST 1178
TCG G ++R VKC GT + C+ +P Q C+L C PP + + + T
Sbjct: 867 KTCGVGVRMRDVKCYQGTDIV----RGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGT 922
Query: 1179 YSAPRTQWRF-GSWTPCSATC 1198
A + G W A C
Sbjct: 923 NCALAIKVNLCGHWYYSKACC 943
Score = 90.9 bits (224), Expect = 1e-17
Identities = 56/190 (29%), Positives = 87/190 (45%), Gaps = 11/190 (5%)
Query: 1541 TRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKR 1600
TRP++ + P +Y W+ + C+ TC G +CV + EV + CD R
Sbjct: 551 TRPKARKQGVSP-ADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTR 609
Query: 1601 PVD-RESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYT-GKENYEYSYQTTIN 1658
P E C+ + C+ W T WSECS TCG+GY+ R+V C ++ + G ++ YS
Sbjct: 610 PEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYS-DLCEA 668
Query: 1659 CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGV-GVMQRSVQCLTNEDQPSHLCHT 1717
+P C R+ W + W C+ CG V+ R ++C +E LC
Sbjct: 669 AEAVRPEERKTC--RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDE----KLCDP 722
Query: 1718 DLKPEERKTC 1727
+ +P K C
Sbjct: 723 NTRPVGEKNC 732
Score = 58.5 bits (140), Expect = 6e-08
Identities = 49/151 (32%), Positives = 60/151 (39%), Gaps = 21/151 (13%)
Query: 1588 NEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKE 1647
N H AR RP R+ Y W CS TC G C Y G E
Sbjct: 544 NRTHKART----RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVR-YDGVE 598
Query: 1648 NYEYSYQTTINCPGTQPPSVHP-CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLT 1706
+ SY + T+P VH C R+C W +W CS +CG G R V+C
Sbjct: 599 -VDDSYCDAL----TRPEPVHEFCAGREC--QPRWETSSWSECSRTCGEGYQFRVVRCWK 651
Query: 1707 ------NEDQPSHLCHTD--LKPEERKTCRN 1729
+ S LC ++PEERKTCRN
Sbjct: 652 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
Score = 33.9 bits (76), Expect = 1.6
Identities = 25/78 (32%), Positives = 31/78 (39%), Gaps = 18/78 (23%)
Query: 1506 WSQCSVSCGRGV--QQRHVGCQ-------------IGTHK---IARETECNPYTRPESER 1547
W+ CS SCG GV Q+RH Q GT K + R EC P R E
Sbjct: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
Query: 1548 DCQGPRCPLYTWRAEEWQ 1565
C +Y R +W+
Sbjct: 116 QCVSFNSHVYNGRTHQWK 133
Score = 33.5 bits (75), Expect = 2.1
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 6/79 (7%)
Query: 981 SSHPKPSNREKCSGECNTGGW--RYSAWTECSKSCDGGTQRRRAICVNTRNDVL---DDS 1035
S+ P++ G T W ++ WT CS+SC GG + C+ R + +
Sbjct: 29 STDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNR 88
Query: 1036 KCTHQEKVTIQRCSEFPCP 1054
CT K Q C CP
Sbjct: 89 TCTGTSK-RYQLCRVQECP 106
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 196 bits (497), Expect = 2e-49
Identities = 110/352 (31%), Positives = 160/352 (45%), Gaps = 25/352 (7%)
Query: 1385 QWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKP-PDREQCNTHACPHDA 1443
+W + C+ C G+ + +C R +G D C+ L +P P E C C
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC--QP 624
Query: 1444 AWSTGPWSSCSVSCGRGHKQRNVYC--MAKDG--SHLESDYCK--HLAKPHGHRKCRGGR 1497
W T WS CS +CG G++ R V C M G S + SD C+ +P + CR
Sbjct: 625 RWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPA 684
Query: 1498 C-PKWKAGAWSQCSVSCG-RGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
C P+W+ WS+C+ CG R V R + C E C+P TRP E++C GP C
Sbjct: 685 CGPQWEMSEWSECTAKCGERSVVTRDIRCS------EDEKLCDPNTRPVGEKNCTGPPCD 738
Query: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYV 1615
W +W C+ +CG+G R V C + V ++C + +P+ C + C
Sbjct: 739 RQ-WTVSDWGPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAH 797
Query: 1616 WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDC 1675
W+ +W C+ TCG+G K+RLV C E+ GK + + +PP C+ R C
Sbjct: 798 WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGL---AKKPPEESTCFERPC 854
Query: 1676 PVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTC 1727
W W C+ +CGVGV R V+C D C +KP R+ C
Sbjct: 855 ---FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRG-CDPLVKPVGRQAC 902
Score = 193 bits (491), Expect = 1e-48
Identities = 129/403 (32%), Positives = 170/403 (42%), Gaps = 64/403 (15%)
Query: 1227 RPVAKEECSVTPCG--QWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
RP A+++ V+P +WK CS TC G + MCV Y +D S CD P
Sbjct: 552 RPKARKQ-GVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRP 610
Query: 1285 ETDQD-CSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSST 1343
E + C+ C R W T W CS T
Sbjct: 611 EPVHEFCAGRECQPR---------------------------------WETSSWSECSRT 637
Query: 1344 CAGGSQRRVVVCQ-------DENGYT-ANDCVERIKPDEQRACESGPC-PQWAYGNWGEC 1394
C G Q RVV C D + Y+ + E ++P+E++ C + C PQW W EC
Sbjct: 638 CGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACGPQWEMSEWSEC 697
Query: 1395 TKLCGG-GIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSC 1453
T CG + TR + C S E+ C+ +P + C C D W+ W C
Sbjct: 698 TAKCGERSVVTRDIRC--SEDEKL----CDPNTRPVGEKNCTGPPC--DRQWTVSDWGPC 749
Query: 1454 SVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK-WKAGAWSQCSVS 1512
S SCG+G R+VYC DG + C+ KP C CP W A W +C+ +
Sbjct: 750 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTT 809
Query: 1513 CGRGVQQRHVGCQI---GTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTK 1569
CGRGV++R V C G + EC +P E C C + W W ECTK
Sbjct: 810 CGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPC--FKWYTSPWSECTK 867
Query: 1570 TCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
TCG G R R V C + V G CD +PV R++C LQPC
Sbjct: 868 TCGVGVRMRDVKCYQGT-DIVRG--CDPLVKPVGRQACDLQPC 907
Score = 190 bits (482), Expect = 1e-47
Identities = 128/440 (29%), Positives = 180/440 (40%), Gaps = 79/440 (17%)
Query: 1036 KCTHQEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWC-QFGEDRLNDRMCDPE 1094
K + K Q S +WK C TC G C ++ ++D CD
Sbjct: 548 KARTRPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDAL 607
Query: 1095 TKPTSM-QTCQQPECAS-WQAGPWGQCSVTCGQGYQLRAVKC---IIGTYMSVVDDNDCN 1149
T+P + + C EC W+ W +CS TCG+GYQ R V+C + + S V + C
Sbjct: 608 TRPEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCE 667
Query: 1150 AA--TRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYV 1207
AA RP + + C P+C P QW W+ C+A CG+ R V
Sbjct: 668 AAEAVRPEERKTCRNPACGP-----------------QWEMSEWSECTAKCGE----RSV 706
Query: 1208 SCRDENGSVADESACATLPRPVAKEECSVTPCG-QWKALDWSSCSVTCGQGRATRQVMCV 1266
RD S DE C RPV ++ C+ PC QW DW CS +CGQGR R V C
Sbjct: 707 VTRDIRCS-EDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPCSGSCGQGRTIRHVYCK 765
Query: 1267 NYSDHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHV 1326
V+ S+C + P C CP
Sbjct: 766 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAH---------------------------- 797
Query: 1327 LGGNQWRTGPWGACSSTCAGGSQRRVVVCQD-ENGY----TANDCVERIKPDEQRACESG 1381
W W C++TC G ++R+V+C + NG + +C KP E+ C
Sbjct: 798 -----WLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFER 852
Query: 1382 PCPQWAYGNWGECTKLCGGGIRTRLVVCQRSNGERFPDL--SCEILDKPPDREQCNTHAC 1439
PC +W W ECTK CG G+R R V C + D+ C+ L KP R+ C+ C
Sbjct: 853 PCFKWYTSPWSECTKTCGVGVRMRDVKCYQGT-----DIVRGCDPLVKPVGRQACDLQPC 907
Query: 1440 ---PHDAAWSTGPWSSCSVS 1456
P D + P ++C+++
Sbjct: 908 PTEPPDDSCQDQPGTNCALA 927
Score = 188 bits (477), Expect = 5e-47
Identities = 121/388 (31%), Positives = 162/388 (41%), Gaps = 45/388 (11%)
Query: 938 RWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN-REKCSGEC 996
RW ++S CSA C G + C +Y ++ VDD +C + +P E C+G
Sbjct: 567 RWKLSSHEPCSATCTTGVMSAYAMCVRYDGVE-----VDDSYCDALTRPEPVHEFCAGRE 621
Query: 997 NTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDS----KCTHQEKVTIQR---CS 1049
W S+W+ECS++C G Q R C + D S C E V + C
Sbjct: 622 CQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
Query: 1050 EFPC-PQWKSGDWSECLVTCG-KGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPE 1107
C PQW+ +WSEC CG + R + C ED +++CDP T+P + C P
Sbjct: 682 NPACGPQWEMSEWSECTAKCGERSVVTRDIRC--SED---EKLCDPNTRPVGEKNCTGPP 736
Query: 1108 C-ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCH 1166
C W WG CS +CGQG +R V C VV ++ C T+P C +C
Sbjct: 737 CDRQWTVSDWGPCSGSCGQGRTIRHVYCKTSD-GRVVPESQCQMETKPLAIHPCGDKNC- 794
Query: 1167 PPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRD-ENGSVADESA--CA 1223
PA W W C+ TCG+G + R V C + NG S C
Sbjct: 795 --PA--------------HWLAQDWERCNTTCGRGVKKRLVLCMELANGKPQTRSGPECG 838
Query: 1224 TLPRPVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYI 1283
+P + C PC +W WS C+ TCG G R V C +D V CD
Sbjct: 839 LAKKPPEESTCFERPCFKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIV---RGCDPLVK 895
Query: 1284 PETDQDCSMSPCPQRTPDSGLAQHPFQN 1311
P Q C + PCP PD P N
Sbjct: 896 PVGRQACDLQPCPTEPPDDSCQDQPGTN 923
Score = 177 bits (450), Expect = 7e-44
Identities = 115/415 (27%), Positives = 174/415 (41%), Gaps = 73/415 (17%)
Query: 985 KPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKC---THQE 1041
+P R++ + W+ S+ CS +C G A+CV +DDS C T E
Sbjct: 552 RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTRPE 611
Query: 1042 KVTIQRCSEFPC-PQWKSGDWSECLVTCGKGHKHRQVWCQ------FGEDRLNDRMCDPE 1094
V + C+ C P+W++ WSEC TCG+G++ R V C F +D +C+
Sbjct: 612 PVH-EFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSD-LCEAA 669
Query: 1095 --TKPTSMQTCQQPECA-SWQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNA 1150
+P +TC+ P C W+ W +C+ CG+ R ++C D+ C+
Sbjct: 670 EAVRPEERKTCRNPACGPQWEMSEWSECTAKCGERSVVTRDIRCS-------EDEKLCDP 722
Query: 1151 ATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR 1210
TRP ++C P C QW W PCS +CG+G +R+V C+
Sbjct: 723 NTRPVGEKNCTGPPCD-----------------RQWTVSDWGPCSGSCGQGRTIRHVYCK 765
Query: 1211 DENGSVADESACATLPRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYS 1269
+G V ES C +P+A C C W A DW C+ TCG+G R V+C+ +
Sbjct: 766 TSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERCNTTCGRGVKKRLVLCMELA 825
Query: 1270 DHVIDRSECDQDYIPETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGG 1329
+ P + P+ GLA+ P + R
Sbjct: 826 NG---------------------KPQTRSGPECGLAKKPPEESTCFERPCF--------- 855
Query: 1330 NQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
+W T PW C+ TC G + R V C + C +KP ++AC+ PCP
Sbjct: 856 -KWYTSPWSECTKTCGVGVRMRDVKCY-QGTDIVRGCDPLVKPVGRQACDLQPCP 908
Score = 150 bits (378), Expect = 2e-35
Identities = 99/309 (32%), Positives = 139/309 (44%), Gaps = 32/309 (10%)
Query: 591 WGSWSPFGTCSRTCGGGIKTAIREC----NRPEPKNGGKYCVGRRMKFKSCNTEPCLKQK 646
WG W+ + CSR+CGGG+ + R C + P G + C G +++ C + C
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 647 RDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGI---LMKDRCKLFCRVAGNTAYYQLRD 703
R FR+EQC F+ +N +W P Y + C L C +
Sbjct: 110 RSFREEQCVSFNSHVYNGR----THQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVPA 165
Query: 704 RVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNSSCKTVAGTF--N 760
R DGT C D +CV G C GCD VL S DKCG+C GD SSC V G +
Sbjct: 166 R--DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKG 223
Query: 761 TVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGNFVVTMAKREI 820
H GY+ V IPAGA +I + + S + LAL+ G + NGN+ V K
Sbjct: 224 NAHLGYSLVTHIPAGARDIQIVERKKSADV-----LALADEAGYYFFNGNYKVDSPK-NF 277
Query: 821 RIGNAVVEYSGS----ETAVERINSTDRIEQELLLQVLSV-GKLYNPDVRYSFNI---PI 872
I VV+Y ET +E I + Q L + V + GK +P + + + + P
Sbjct: 278 NIAGTVVKYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGK--SPSITFEYTLLQPPH 335
Query: 873 EDKPQQFYW 881
E +PQ Y+
Sbjct: 336 ESRPQPIYY 344
Score = 143 bits (361), Expect = 1e-33
Identities = 108/381 (28%), Positives = 146/381 (38%), Gaps = 72/381 (18%)
Query: 882 NSHGPWQACSKPCQ-GERKRKLVCTRESDQLTVSDQRCDRLPQPGHITEPC-GTDCDLRW 939
+SH P CS C G +C R D + V D CD L +P + E C G +C RW
Sbjct: 571 SSHEP---CSATCTTGVMSAYAMCVRY-DGVEVDDSYCDALTRPEPVHEFCAGRECQPRW 626
Query: 940 HVASRSECSAQCGLGYRTLDIYCAK----------YSRLDGKTEKV-------------- 975
+S SECS CG GY+ + C K YS L E V
Sbjct: 627 ETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCRNPACG 686
Query: 976 -----------------------------DDGFCSSHPKPSNREKCSGECNTGGWRYSAW 1006
D+ C + +P + C+G W S W
Sbjct: 687 PQWEMSEWSECTAKCGERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDW 746
Query: 1007 TECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEK-VTIQRCSEFPCP-QWKSGDWSEC 1064
CS SC G R C + V+ +S+C + K + I C + CP W + DW C
Sbjct: 747 GPCSGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCPAHWLAQDWERC 806
Query: 1065 LVTCGKGHKHRQVWC-QFGEDRLNDRM---CDPETKPTSMQTCQQPECASWQAGPWGQCS 1120
TCG+G K R V C + + R C KP TC + C W PW +C+
Sbjct: 807 NTTCGRGVKKRLVLCMELANGKPQTRSGPECGLAKKPPEESTCFERPCFKWYTSPWSECT 866
Query: 1121 VTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC--HPPPAAPETRRST 1178
TCG G ++R VKC GT + C+ +P Q C+L C PP + + + T
Sbjct: 867 KTCGVGVRMRDVKCYQGTDIV----RGCDPLVKPVGRQACDLQPCPTEPPDDSCQDQPGT 922
Query: 1179 YSAPRTQWRF-GSWTPCSATC 1198
A + G W A C
Sbjct: 923 NCALAIKVNLCGHWYYSKACC 943
Score = 90.9 bits (224), Expect = 1e-17
Identities = 56/190 (29%), Positives = 87/190 (45%), Gaps = 11/190 (5%)
Query: 1541 TRPESERDCQGPRCPLYTWRAEEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKR 1600
TRP++ + P +Y W+ + C+ TC G +CV + EV + CD R
Sbjct: 551 TRPKARKQGVSP-ADMYRWKLSSHEPCSATCTTGVMSAYAMCVRYDGVEVDDSYCDALTR 609
Query: 1601 PVD-RESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYT-GKENYEYSYQTTIN 1658
P E C+ + C+ W T WSECS TCG+GY+ R+V C ++ + G ++ YS
Sbjct: 610 PEPVHEFCAGRECQPRWETSSWSECSRTCGEGYQFRVVRCWKMLSPGFDSSVYS-DLCEA 668
Query: 1659 CPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGV-GVMQRSVQCLTNEDQPSHLCHT 1717
+P C R+ W + W C+ CG V+ R ++C +E LC
Sbjct: 669 AEAVRPEERKTC--RNPACGPQWEMSEWSECTAKCGERSVVTRDIRCSEDE----KLCDP 722
Query: 1718 DLKPEERKTC 1727
+ +P K C
Sbjct: 723 NTRPVGEKNC 732
Score = 58.5 bits (140), Expect = 6e-08
Identities = 49/151 (32%), Positives = 60/151 (39%), Gaps = 21/151 (13%)
Query: 1588 NEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKE 1647
N H AR RP R+ Y W CS TC G C Y G E
Sbjct: 544 NRTHKART----RPKARKQGVSPADMYRWKLSSHEPCSATCTTGVMSAYAMCVR-YDGVE 598
Query: 1648 NYEYSYQTTINCPGTQPPSVHP-CYLRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLT 1706
+ SY + T+P VH C R+C W +W CS +CG G R V+C
Sbjct: 599 -VDDSYCDAL----TRPEPVHEFCAGREC--QPRWETSSWSECSRTCGEGYQFRVVRCWK 651
Query: 1707 ------NEDQPSHLCHTD--LKPEERKTCRN 1729
+ S LC ++PEERKTCRN
Sbjct: 652 MLSPGFDSSVYSDLCEAAEAVRPEERKTCRN 682
Score = 33.9 bits (76), Expect = 1.6
Identities = 25/78 (32%), Positives = 31/78 (39%), Gaps = 18/78 (23%)
Query: 1506 WSQCSVSCGRGV--QQRHVGCQ-------------IGTHK---IARETECNPYTRPESER 1547
W+ CS SCG GV Q+RH Q GT K + R EC P R E
Sbjct: 56 WTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDGRSFREE 115
Query: 1548 DCQGPRCPLYTWRAEEWQ 1565
C +Y R +W+
Sbjct: 116 QCVSFNSHVYNGRTHQWK 133
Score = 33.5 bits (75), Expect = 2.1
Identities = 22/79 (27%), Positives = 32/79 (40%), Gaps = 6/79 (7%)
Query: 981 SSHPKPSNREKCSGECNTGGW--RYSAWTECSKSCDGGTQRRRAICVNTRNDVL---DDS 1035
S+ P++ G T W ++ WT CS+SC GG + C+ R + +
Sbjct: 29 STDNSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNR 88
Query: 1036 KCTHQEKVTIQRCSEFPCP 1054
CT K Q C CP
Sbjct: 89 TCTGTSK-RYQLCRVQECP 106
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,259,594
Number of Sequences: 37866
Number of extensions: 4732679
Number of successful extensions: 16620
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 11459
Number of HSP's gapped (non-prelim): 1733
length of query: 1935
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1818
effective length of database: 13,817,196
effective search space: 25119662328
effective search space used: 25119662328
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.