Search of human proteins with 33598958

Search of human proteins with 33598958

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|33598958 ADP-ribosylation factor-like 2-like 1 isoform 2
[Homo sapiens]
         (321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33598958 ADP-ribosylation factor-like 2-like 1 isoform 2 [Hom...   667   0.0  
gi|33598956 ADP-ribosylation factor-like 2-like 1 isoform 1 [Hom...   620   e-178
gi|241982689 ADP-ribosylation factor-like 13 isoform b [Homo sap...    69   7e-12
gi|241982687 ADP-ribosylation factor-like 13 isoform a [Homo sap...    69   7e-12
gi|124248533 ADP-ribosylation factor-like 13 isoform a [Homo sap...    69   7e-12
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      49   5e-06
gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]      49   5e-06
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       49   5e-06
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    47   2e-05
gi|148746195 trichohyalin [Homo sapiens]                               47   3e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]             47   3e-05
gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]                       46   4e-05
gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]                       46   4e-05
gi|22758136 MAP7 domain containing 2 [Homo sapiens]                    46   4e-05
gi|187761324 shootin1 isoform a [Homo sapiens]                         45   7e-05
gi|50511340 shootin1 isoform b [Homo sapiens]                          45   7e-05
gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]      45   1e-04
gi|148839339 nexilin (F actin binding protein) [Homo sapiens]          45   1e-04
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    44   3e-04
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    44   3e-04
gi|56549694 enabled homolog isoform a [Homo sapiens]                   43   4e-04
gi|39930375 enabled homolog isoform b [Homo sapiens]                   43   4e-04
gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo sapi...    43   4e-04
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            42   6e-04
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            42   7e-04
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    42   7e-04
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    42   0.001
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    42   0.001
gi|57863314 vacuolar protein sorting 37C [Homo sapiens]                42   0.001
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    41   0.001

>gi|33598958 ADP-ribosylation factor-like 2-like 1 isoform 2 [Homo
           sapiens]
          Length = 321

 Score =  667 bits (1720), Expect = 0.0
 Identities = 321/321 (100%), Positives = 321/321 (100%)

Query: 1   MFSLMASCCGWFKRWREPVRLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSA 60
           MFSLMASCCGWFKRWREPVRLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSA
Sbjct: 1   MFSLMASCCGWFKRWREPVRLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSA 60

Query: 61  ISGYGKKIDKSIKKGLYWLLHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLR 120
           ISGYGKKIDKSIKKGLYWLLHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLR
Sbjct: 61  ISGYGKKIDKSIKKGLYWLLHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLR 120

Query: 121 EERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGC 180
           EERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGC
Sbjct: 121 EERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGC 180

Query: 181 HLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKK 240
           HLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKK
Sbjct: 181 HLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKK 240

Query: 241 TKKLRMKRNHRVEPLNIDDCAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYR 300
           TKKLRMKRNHRVEPLNIDDCAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYR
Sbjct: 241 TKKLRMKRNHRVEPLNIDDCAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYR 300

Query: 301 KPLPPLAVPQRPNSDAHDVIS 321
           KPLPPLAVPQRPNSDAHDVIS
Sbjct: 301 KPLPPLAVPQRPNSDAHDVIS 321


>gi|33598956 ADP-ribosylation factor-like 2-like 1 isoform 1 [Homo
           sapiens]
          Length = 428

 Score =  620 bits (1600), Expect = e-178
 Identities = 301/301 (100%), Positives = 301/301 (100%)

Query: 21  LANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIKKGLYWLL 80
           LANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIKKGLYWLL
Sbjct: 128 LANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIKKGLYWLL 187

Query: 81  HVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLA 140
           HVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLA
Sbjct: 188 HVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLA 247

Query: 141 ELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHN 200
           ELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHN
Sbjct: 248 ELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHN 307

Query: 201 GQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDC 260
           GQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDC
Sbjct: 308 GQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDC 367

Query: 261 APESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRPNSDAHDVI 320
           APESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRPNSDAHDVI
Sbjct: 368 APESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRPNSDAHDVI 427

Query: 321 S 321
           S
Sbjct: 428 S 428



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 20/20 (100%), Positives = 20/20 (100%)

Query: 1  MFSLMASCCGWFKRWREPVR 20
          MFSLMASCCGWFKRWREPVR
Sbjct: 1  MFSLMASCCGWFKRWREPVR 20


>gi|241982689 ADP-ribosylation factor-like 13 isoform b [Homo
           sapiens]
          Length = 256

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 34/63 (53%), Positives = 45/63 (71%)

Query: 21  LANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIKKGLYWLL 80
           LANKQDK+ AL   D+I+ L L+KLV E+KC C++EPCSAI    ++  + I +GL WLL
Sbjct: 128 LANKQDKKKALMPCDIIDYLLLKKLVKENKCPCRVEPCSAIRNLERRNHQPIVEGLRWLL 187

Query: 81  HVI 83
            VI
Sbjct: 188 AVI 190


>gi|241982687 ADP-ribosylation factor-like 13 isoform a [Homo
           sapiens]
          Length = 290

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 34/63 (53%), Positives = 45/63 (71%)

Query: 21  LANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIKKGLYWLL 80
           LANKQDK+ AL   D+I+ L L+KLV E+KC C++EPCSAI    ++  + I +GL WLL
Sbjct: 128 LANKQDKKKALMPCDIIDYLLLKKLVKENKCPCRVEPCSAIRNLERRNHQPIVEGLRWLL 187

Query: 81  HVI 83
            VI
Sbjct: 188 AVI 190


>gi|124248533 ADP-ribosylation factor-like 13 isoform a [Homo
           sapiens]
          Length = 290

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 34/63 (53%), Positives = 45/63 (71%)

Query: 21  LANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAISGYGKKIDKSIKKGLYWLL 80
           LANKQDK+ AL   D+I+ L L+KLV E+KC C++EPCSAI    ++  + I +GL WLL
Sbjct: 128 LANKQDKKKALMPCDIIDYLLLKKLVKENKCPCRVEPCSAIRNLERRNHQPIVEGLRWLL 187

Query: 81  HVI 83
            VI
Sbjct: 188 AVI 190


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 53/225 (23%), Positives = 99/225 (44%), Gaps = 34/225 (15%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           RI+++  E+R +EEQ+++ER +  RKL+E+ +Q   E                     Q 
Sbjct: 397 RIEEQKEERRRVEEQQRREREQ--RKLQEKEQQRRLED-------------------MQA 435

Query: 153 IASVIIENEGKLEREKKNQKMEKDSDGCHLKHKM--EHEQIET--QGQVNHNGQKNNEFG 208
           +       + + E+E K +++E+      L+ ++  EH  +++  Q Q     QK  +  
Sbjct: 436 LRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495

Query: 209 LVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTP- 267
           L+   ++ L    +  +  D+P+   A   ++  ++  ++N  +         PE P P 
Sbjct: 496 LLPGDRKPLYHYGRGMNPADKPAW--AREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQ 553

Query: 268 --PPPPPPVGWGTPKVTRLPKLEPLGETHHN-DFYRKPLPPLAVP 309
             P PP P+   TP + R   +EP    H +   +R PL P A P
Sbjct: 554 ASPGPPGPLS-QTPPMQR--PVEPQEGPHKSLVAHRVPLKPYAAP 595



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 32/158 (20%), Positives = 67/158 (42%), Gaps = 18/158 (11%)

Query: 94  IQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPI 153
           I+ + TE++     + ++  +R RK R E+++ E E       SG  E D       +P 
Sbjct: 289 IRDQPTERQV--RIQLKDHIDRSRKKRGEKEETEYEY------SGSEEEDDSHGEEGEPS 340

Query: 154 ASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENY 213
           + + +  E  L RE    + E  S+   LK + + +Q + +    H          +++ 
Sbjct: 341 SIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH----------IKHL 390

Query: 214 KEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
                ++++ + E  R   E    +++ +KL+ K   R
Sbjct: 391 LHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428


>gi|27436917 misshapen/NIK-related kinase isoform 3 [Homo sapiens]
          Length = 1332

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 53/225 (23%), Positives = 99/225 (44%), Gaps = 34/225 (15%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           RI+++  E+R +EEQ+++ER +  RKL+E+ +Q   E                     Q 
Sbjct: 397 RIEEQKEERRRVEEQQRREREQ--RKLQEKEQQRRLED-------------------MQA 435

Query: 153 IASVIIENEGKLEREKKNQKMEKDSDGCHLKHKM--EHEQIET--QGQVNHNGQKNNEFG 208
           +       + + E+E K +++E+      L+ ++  EH  +++  Q Q     QK  +  
Sbjct: 436 LRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495

Query: 209 LVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTP- 267
           L+   ++ L    +  +  D+P+   A   ++  ++  ++N  +         PE P P 
Sbjct: 496 LLPGDRKPLYHYGRGMNPADKPAW--AREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQ 553

Query: 268 --PPPPPPVGWGTPKVTRLPKLEPLGETHHN-DFYRKPLPPLAVP 309
             P PP P+   TP + R   +EP    H +   +R PL P A P
Sbjct: 554 ASPGPPGPLS-QTPPMQR--PVEPQEGPHKSLVAHRVPLKPYAAP 595



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 32/158 (20%), Positives = 67/158 (42%), Gaps = 18/158 (11%)

Query: 94  IQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPI 153
           I+ + TE++     + ++  +R RK R E+++ E E       SG  E D       +P 
Sbjct: 289 IRDQPTERQV--RIQLKDHIDRSRKKRGEKEETEYEY------SGSEEEDDSHGEEGEPS 340

Query: 154 ASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENY 213
           + + +  E  L RE    + E  S+   LK + + +Q + +    H          +++ 
Sbjct: 341 SIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH----------IKHL 390

Query: 214 KEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
                ++++ + E  R   E    +++ +KL+ K   R
Sbjct: 391 LHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 49.3 bits (116), Expect = 5e-06
 Identities = 53/225 (23%), Positives = 99/225 (44%), Gaps = 34/225 (15%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           RI+++  E+R +EEQ+++ER +  RKL+E+ +Q   E                     Q 
Sbjct: 397 RIEEQKEERRRVEEQQRREREQ--RKLQEKEQQRRLED-------------------MQA 435

Query: 153 IASVIIENEGKLEREKKNQKMEKDSDGCHLKHKM--EHEQIET--QGQVNHNGQKNNEFG 208
           +       + + E+E K +++E+      L+ ++  EH  +++  Q Q     QK  +  
Sbjct: 436 LRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495

Query: 209 LVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTP- 267
           L+   ++ L    +  +  D+P+   A   ++  ++  ++N  +         PE P P 
Sbjct: 496 LLPGDRKPLYHYGRGMNPADKPAW--AREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQ 553

Query: 268 --PPPPPPVGWGTPKVTRLPKLEPLGETHHN-DFYRKPLPPLAVP 309
             P PP P+   TP + R   +EP    H +   +R PL P A P
Sbjct: 554 ASPGPPGPLS-QTPPMQR--PVEPQEGPHKSLVAHRVPLKPYAAP 595



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 32/158 (20%), Positives = 67/158 (42%), Gaps = 18/158 (11%)

Query: 94  IQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPI 153
           I+ + TE++     + ++  +R RK R E+++ E E       SG  E D       +P 
Sbjct: 289 IRDQPTERQV--RIQLKDHIDRSRKKRGEKEETEYEY------SGSEEEDDSHGEEGEPS 340

Query: 154 ASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENY 213
           + + +  E  L RE    + E  S+   LK + + +Q + +    H          +++ 
Sbjct: 341 SIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH----------IKHL 390

Query: 214 KEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
                ++++ + E  R   E    +++ +KL+ K   R
Sbjct: 391 LHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 48/210 (22%), Positives = 83/210 (39%), Gaps = 28/210 (13%)

Query: 92   ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELD----GTSGLAELDPEPT 147
            E  ++E  E+   EE+ ++E  E   +  EE ++ E+E  E++    GT+G    +  P 
Sbjct: 919  EYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPP 978

Query: 148  NPFQPIASVIIENEGKLEREKK---------NQKMEKDSDGCHLKHKMEHEQIETQGQVN 198
             P  P A    E+  K++ E +          +   ++  G      +  E + +QG+V 
Sbjct: 979  PPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVE 1038

Query: 199  HNGQK----NNEFGLVENYKEALTQQLKNEDE---------TDRPSLESANGKKKTKKLR 245
              G+          LVE    A    L+ E E          + P+ E    + + + L+
Sbjct: 1039 REGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQ 1098

Query: 246  MKRNHRVEPLNID--DCAPESPTPPPPPPP 273
             K       +  D  DC P+   PPPP  P
Sbjct: 1099 EKEQDDTAAMLADFIDCPPDDEKPPPPTEP 1128



 Score = 32.7 bits (73), Expect = 0.44
 Identities = 30/138 (21%), Positives = 53/138 (38%), Gaps = 22/138 (15%)

Query: 155 SVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYK 214
           +VI  N    E E++ ++ E++ +    +   E E+ + +       ++  EF   E ++
Sbjct: 879 TVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFE--EEFE 936

Query: 215 EA---LTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTPPPPP 271
           E    L ++ + EDE +   LE                  VE L       E     PPP
Sbjct: 937 EEEGELEEEEEEEDEEEEEELEE-----------------VEDLEFGTAGGEVEEGAPPP 979

Query: 272 PPVGWGTPKVTRLPKLEP 289
           P +    P     PK++P
Sbjct: 980 PTLPPALPPPESPPKVQP 997



 Score = 31.6 bits (70), Expect = 0.99
 Identities = 20/74 (27%), Positives = 36/74 (48%), Gaps = 7/74 (9%)

Query: 105 EEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKL 164
           EE+E++E  E   +  EE    E+E+ E +      E + E    F+       E EG+L
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFE-------EEEGEL 942

Query: 165 EREKKNQKMEKDSD 178
           E E++ +  E++ +
Sbjct: 943 EEEEEEEDEEEEEE 956



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 14/31 (45%), Positives = 15/31 (48%)

Query: 261 APESPTPPPPPPPVGWGTPKVTRLPKLEPLG 291
           A   P PPPPPPP     P     P+L P G
Sbjct: 834 AAPGPLPPPPPPPPPVPGPVTLPPPQLVPEG 864



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 19/57 (33%), Positives = 21/57 (36%), Gaps = 6/57 (10%)

Query: 262 PESPTPPPPPPPVGWGTPKV------TRLPKLEPLGETHHNDFYRKPLPPLAVPQRP 312
           PE   P PPPPP G   P +      T  P +    E         PLPP   P  P
Sbjct: 792 PEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPP 848


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 35/163 (21%), Positives = 76/163 (46%), Gaps = 27/163 (16%)

Query: 92  ERIQKETTE-QRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPF 150
           E++Q+E  + QR L+E+E+Q R    ++LR ER++ EQ+Q  L                 
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL----------------- 300

Query: 151 QPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGL- 209
                     E +L R+++ ++ E+  +    + + E ++   + Q+    ++  E  L 
Sbjct: 301 --------RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352

Query: 210 VENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRV 252
            E  +E   QQL+ E E +R   +    ++  ++ +++R  ++
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395



 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 37/166 (22%), Positives = 81/166 (48%), Gaps = 9/166 (5%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           R Q+E  EQR   ++E++   +R+R  ++ R++ E+ + +L        L+ E     Q 
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERRE--QR 566

Query: 153 IASVIIENEGKL---EREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGL 209
           +     E   +L   E E++ Q+++++ +   L+ +++ E++E   Q     Q+      
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQEE-RLEQRLKREEVERLEQEERREQRLKR--- 622

Query: 210 VENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPL 255
            E  +E   Q LK+E++ +R   +    +++ ++ R+KR    E L
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668



 Score = 44.3 bits (103), Expect = 1e-04
 Identities = 36/179 (20%), Positives = 90/179 (50%), Gaps = 19/179 (10%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREER-----KQNEQEQAELDGTSGLAELDPEP 146
           +++++E  E+R  ++ E++ R +R+++ +EER     ++ E E+ E +      + D E 
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE 482

Query: 147 TNPFQPIASVIIENEGKLEREKKNQKMEKDSD---GCHLKHKMEHEQIE----TQGQVNH 199
               + +   + E E + ++E++ Q++ ++ +      LK + E E+++    ++ Q+  
Sbjct: 483 ERRERWLK--LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540

Query: 200 NGQKNNEFGLVENYKEALTQQ-----LKNEDETDRPSLESANGKKKTKKLRMKRNHRVE 253
             ++  E  L    ++ L Q+     LK E E  R  L     +++ ++L+ ++  R+E
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599



 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 42/176 (23%), Positives = 82/176 (46%), Gaps = 26/176 (14%)

Query: 83  IARDFDALNERIQKETTEQRALEE-------QEKQERAERVRKLREERKQ---NEQEQAE 132
           + R+ +   E++ K   E+R  +E       +E++ER +++ K  EER+Q     +++  
Sbjct: 538 LRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597

Query: 133 LDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIE 192
           L+      E++              +E E + E+  K ++ E++     LK + + E+  
Sbjct: 598 LEQRLKREEVER-------------LEQEERREQRLKREEPEEERRQQLLKSEEQEER-- 642

Query: 193 TQGQVNHNGQKNNEFGLV-ENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMK 247
            Q Q+    Q+  E  L  E  +E L Q+LK E E +R   E A  +++  + R+K
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 35/161 (21%), Positives = 76/161 (47%), Gaps = 18/161 (11%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           R Q+E  EQ+   EQE++ R +++R+ +EE ++ +Q + E          + +     Q 
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ-----LRREQQLRREQQL 395

Query: 153 IASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVEN 212
                +  E +L RE++ ++ ++      L+ + E E+ E + +     Q+      ++ 
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR------LKR 449

Query: 213 YKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVE 253
            +E     LK E+ET+R        +++ +K ++KR+   E
Sbjct: 450 EQEERRDWLKREEETER-------HEQERRKQQLKRDQEEE 483



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 33/176 (18%), Positives = 75/176 (42%), Gaps = 5/176 (2%)

Query: 85   RDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQ-AELDGTSGLAELD 143
            R F    +++ ++  +++  EE+++  R ER RK  EE +Q  QE+  +      L +  
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER 1473

Query: 144  PEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQK 203
             E     Q      +E E +L R+++++K  +      L+ +    +   + Q  H  Q+
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ----ELRSQEPERKFLEEEQQLHRQQR 1529

Query: 204  NNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDD 259
              +F   E       +  +   + DR   E    +++ ++ ++ R  R     +++
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585



 Score = 39.3 bits (90), Expect = 0.005
 Identities = 37/170 (21%), Positives = 80/170 (47%), Gaps = 19/170 (11%)

Query: 85   RDFDALNERIQKETTEQRALEEQEKQERAERVRKLREE---RKQNEQEQAELDGTSGLAE 141
            R F    ++++++  E++ L+E+++  R E  RK REE   R++ EQEQ           
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI- 1749

Query: 142  LDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNG 201
            L+ E   P +         E +L R+++++K  ++     L+ + E +Q+ +Q     + 
Sbjct: 1750 LEEEQLRPER--------EEQQLRRQERDRKFREEE---QLRQEREEQQLRSQ----ESD 1794

Query: 202  QKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
            +K  E   +   +E    + +  D   R   E    +++ ++LR +R+ +
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ 1844



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 38/181 (20%), Positives = 79/181 (43%), Gaps = 21/181 (11%)

Query: 92   ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
            + +Q+E  EQ   EE+EK+   ER R+ REE ++ +QE+ +L G         E    ++
Sbjct: 1024 DELQQEE-EQLLREEREKRRLQERERQYREE-EELQQEEEQLLGEERETRRRQELERQYR 1081

Query: 152  PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHE---------------QIETQGQ 196
                +  E E  L  E + ++ ++    C  + +++ E               ++E Q +
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 197  VNHNGQKNNEFGLVE----NYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRV 252
                 Q+  E  L E      ++ L +Q + E+E  +   +    +++ ++   +R +R 
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201

Query: 253  E 253
            E
Sbjct: 1202 E 1202



 Score = 38.1 bits (87), Expect = 0.011
 Identities = 35/162 (21%), Positives = 74/162 (45%), Gaps = 13/162 (8%)

Query: 92   ERIQKETTEQRALEEQEKQ--ERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNP 149
            E  +K   E++ L+E+E+Q   R ER RK REE  +++++        G   L+ E    
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ--------GRKFLEEEQRLR 1384

Query: 150  FQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGL 209
             Q      ++ E +L  +++ Q++ +D D    K + E +Q+  Q +     ++  +   
Sbjct: 1385 RQERERKFLKEEQQLRCQEREQQLRQDRD---RKFREEEQQLSRQERDRKFREEEQQVRR 1441

Query: 210  VENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
             E  ++ L ++ +   E  R   E     ++ ++ ++ R  R
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483



 Score = 37.7 bits (86), Expect = 0.014
 Identities = 34/166 (20%), Positives = 71/166 (42%), Gaps = 24/166 (14%)

Query: 90  LNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNP 149
           L+ R       +R L  +E+Q+R +R     EE++Q  +++ E +      EL       
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE-----KELQ------ 832

Query: 150 FQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQ----VNHNGQKNN 205
                   +E E +L+R ++ Q+++++ DG     +    Q + + Q         +K  
Sbjct: 833 -------FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 206 EFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
              L    K AL +QL+ E +  +   E    +++ K+ R ++  +
Sbjct: 886 RHTLYA--KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 42/171 (24%), Positives = 78/171 (45%), Gaps = 28/171 (16%)

Query: 92  ERIQKETTEQRALEEQE------------------KQERAERV--RKLREERKQNEQEQA 131
           +R+++E  EQR   EQE                  K+E+ ER+  R  REE ++ EQE+ 
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615

Query: 132 ELDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQI 191
                  L   +PE     Q + S   E E + +++ + ++ E+      LK + E E++
Sbjct: 616 R---EQRLKREEPEEERRQQLLKSE--EQEERRQQQLRREQQERREQ--RLKREEEEERL 668

Query: 192 ETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTK 242
           E + +  H  ++  E  L E  +E   +++K+     +  LES    +++K
Sbjct: 669 EQRLKREHE-EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK 718



 Score = 36.6 bits (83), Expect = 0.031
 Identities = 35/181 (19%), Positives = 76/181 (41%), Gaps = 14/181 (7%)

Query: 85  RDFDALNERIQKETTEQRALEEQEKQERAERV-------RKLREERKQNEQEQAELDGTS 137
           R+     E+++K   ++   E QE++++ +R+       RK  EER++ ++E+ E     
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328

Query: 138 GLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHE-------Q 190
              E   E     +       +   + E E++ Q++ ++ +    + ++  E       Q
Sbjct: 329 EQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQ 388

Query: 191 IETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNH 250
           +  + Q+    Q   E  L    +    QQL+ E +  R   E  + +K  ++ R +R  
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448

Query: 251 R 251
           R
Sbjct: 449 R 449



 Score = 35.8 bits (81), Expect = 0.052
 Identities = 35/169 (20%), Positives = 76/169 (44%), Gaps = 13/169 (7%)

Query: 89   ALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTN 148
            AL E+++KE    +  EE+ ++E  E+ R+  +ER+  E+EQ + +    L E   +   
Sbjct: 894  ALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953

Query: 149  PFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFG 208
                      E E +  ++KK Q+ E+   G   + +   E+ +   +     Q+  +  
Sbjct: 954  Q---------ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL 1004

Query: 209  LVENYK---EALTQQLKNEDETDRPSLESANGKKKTKKLR-MKRNHRVE 253
              E  K   +   +Q + +DE  +   +    +++ ++L+  +R +R E
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREE 1053



 Score = 35.4 bits (80), Expect = 0.068
 Identities = 30/170 (17%), Positives = 72/170 (42%), Gaps = 1/170 (0%)

Query: 83  IARDFDALNERIQKETTEQRALEEQEKQERAER-VRKLREERKQNEQEQAELDGTSGLAE 141
           + R+     ++ Q+   EQ+   +QE++ R ++  R+ ++ER++ ++E+ E        E
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345

Query: 142 LDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNG 201
              +     Q       +   + E E++ Q++ ++      +     +Q+  + Q+    
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405

Query: 202 QKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
           Q   E  L    +    QQL+ E E +R   +    +++ +  R +   R
Sbjct: 406 QLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455



 Score = 35.0 bits (79), Expect = 0.089
 Identities = 35/170 (20%), Positives = 69/170 (40%), Gaps = 14/170 (8%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           R Q+E  EQR L+ +E++ER E+  K   E ++ EQE AE +       +          
Sbjct: 649 REQQERREQR-LKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQ 707

Query: 153 IASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVEN 212
           + S     + K+    + Q+ ++       K +    +++ Q +   + Q+       E 
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQE-----EE 762

Query: 213 YKEALTQQLKNEDETD--------RPSLESANGKKKTKKLRMKRNHRVEP 254
            +   T Q + E++++        RP L     ++   + R +R  R  P
Sbjct: 763 QRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP 812



 Score = 35.0 bits (79), Expect = 0.089
 Identities = 39/170 (22%), Positives = 77/170 (45%), Gaps = 18/170 (10%)

Query: 92   ERIQKETTEQRALEEQEK--QERAERVRK------LREERKQNEQEQAELDGTSGLAELD 143
            +R +K   E++ L  QE+  Q R +R RK      LR+ER++ +  + E D    L E  
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 144  PEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQI--ETQGQVNHNG 201
                   Q      +E+E +L R++  Q++ ++ D    +   E EQ+  E + Q  H  
Sbjct: 1588 VRR----QEQERKFMEDEQQLRRQEGQQQLRQERD----RKFREDEQLLQEREEQQLHRQ 1639

Query: 202  QKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
            +++ +F   E       ++ +   + DR   E     ++ ++ +++R  R
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689



 Score = 35.0 bits (79), Expect = 0.089
 Identities = 20/44 (45%), Positives = 30/44 (68%), Gaps = 4/44 (9%)

Query: 89   ALNERIQKETTEQRALEEQEKQERAERVRKLREE--RKQNEQEQ 130
            A  E+ ++E  EQ   +E+E++ R ER RKLREE  R+Q ++EQ
Sbjct: 1852 ATQEKSRRE--EQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893



 Score = 33.9 bits (76), Expect = 0.20
 Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 7/145 (4%)

Query: 92   ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
            E +Q+E  EQ   EE EK+ R ER R+ REE ++ +QE+ +L           E    ++
Sbjct: 1084 EELQQEE-EQLLREEPEKRRRQERERQCREE-EELQQEEEQLLREEREKRRRQELERQYR 1141

Query: 152  PIASVIIENEGKLERE---KKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFG 208
                V  E E  L  E   ++ Q++E+       + + E EQ+  + Q     ++  ++ 
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLREEQEKRRQERERQYR 1200

Query: 209  LVENYKEALTQQLKNEDETDRPSLE 233
              E  +    +Q +  DE  R  L+
Sbjct: 1201 EEEELQRQKRKQ-RYRDEDQRSDLK 1224



 Score = 33.1 bits (74), Expect = 0.34
 Identities = 31/163 (19%), Positives = 77/163 (47%), Gaps = 13/163 (7%)

Query: 95  QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEP-TNPFQPI 153
           ++++ +Q  LE++++Q R E + + R+E ++ E+ +AE +        + E   +  Q  
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211

Query: 154 ASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENY 213
              ++E   K   EK+ Q+ E+       + ++  E+ E + +      +  E  L E  
Sbjct: 212 RRELLELRRKGREEKQQQRRER-------QDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264

Query: 214 KEALTQQLKNEDE----TDRPSLESANGKKKTKKLRMKRNHRV 252
            +   ++L+ E+E     +R  L     +++ ++ R++R  ++
Sbjct: 265 PQR-QRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306



 Score = 33.1 bits (74), Expect = 0.34
 Identities = 32/172 (18%), Positives = 72/172 (41%), Gaps = 3/172 (1%)

Query: 83   IARDFDALNERIQKETTEQRALEEQEKQERAERVRKLRE-ERKQNEQEQAELDGTSGLA- 140
            + R +    E  Q+E    R  +E+ +QER  + R+  E +R++ +Q   + D  S L  
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225

Query: 141  ELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHN 200
            + +PE  N  +         E +  R+ ++ ++        L+H +  +Q   + Q    
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285

Query: 201  -GQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
              Q++  F   E  +    ++ K  D   +   +    +++ K+ R + + +
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 15/38 (39%), Positives = 25/38 (65%)

Query: 92   ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQE 129
            E++Q E  EQR  +E+++Q RAE     +E+ ++ EQE
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQE 1863



 Score = 31.2 bits (69), Expect = 1.3
 Identities = 28/161 (17%), Positives = 71/161 (44%), Gaps = 3/161 (1%)

Query: 92   ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
            +++++E   +   +EQ  QER E+    +E  ++  +E+ +L       +L  +    F+
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670

Query: 152  PIASVIIE-NEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLV 210
                ++ E  E +L R+++++K  ++     L+ +    +   + Q     +   +F   
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQ--QLRRQERERKFLQEEQQLRRQELERKFREE 1728

Query: 211  ENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
            E  ++   Q+     E  R  LE    + + ++ +++R  R
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQER 1769



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 36/157 (22%), Positives = 68/157 (43%), Gaps = 12/157 (7%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQ-NEQEQAELDGTSGLAELDPEPTNPF 150
           E+ +K    +  L+ QE +ERA R ++  E+R+    Q QAE     G   L   P    
Sbjct: 734 EQEEKRRRRESELQWQE-EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLRE 792

Query: 151 QPIASVIIENEGKLER-------EKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQK 203
           Q    +  E   + E+       EK+ ++ ++      L+   E EQ++ + +      +
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ--LQ 850

Query: 204 NNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKK 240
             E GL E+ +   +Q+ +  D+  R  LE    +++
Sbjct: 851 EEEDGLQEDQERRRSQE-QRRDQKWRWQLEEERKRRR 886



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 21/92 (22%), Positives = 40/92 (43%), Gaps = 19/92 (20%)

Query: 100  EQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIE 159
            EQ  LEEQE++ R ER R+ R E +   QE++  +                      + +
Sbjct: 1826 EQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE-------------------EQELWQ 1866

Query: 160  NEGKLEREKKNQKMEKDSDGCHLKHKMEHEQI 191
             E +  R+++ +K+ ++      K +  H Q+
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQRHRQV 1898



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 28/157 (17%), Positives = 64/157 (40%), Gaps = 29/157 (18%)

Query: 106 EQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKLE 165
           ++EK+ R +    L ++R+Q E ++                   F+P    + E  G+  
Sbjct: 96  DEEKRARCDGKESLLQDRRQEEDQRR------------------FEPRDRQLEEEPGQRR 137

Query: 166 REKKNQKMEKDSDGCHLKHKMEH----------EQIETQGQV-NHNGQKNNEFGLVENYK 214
           R+K+ ++  + ++G     K E           E++  Q Q      ++  E   +++ K
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197

Query: 215 EALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
              T++  +E++  R  L     K + +K + +R  +
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 15/43 (34%), Positives = 28/43 (65%), Gaps = 2/43 (4%)

Query: 90  LNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAE 132
           L +R Q+E  +QR  E +++Q   E  ++ R++R++ E+E AE
Sbjct: 110 LQDRRQEE--DQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150


>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
          Length = 2817

 Score = 46.6 bits (109), Expect = 3e-05
 Identities = 38/162 (23%), Positives = 70/162 (43%), Gaps = 2/162 (1%)

Query: 95  QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPE-PTNPFQPI 153
           + E  +QR  ++ E     ER RK REE ++  +EQ +      L  LD +      QP 
Sbjct: 441 EDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPS 500

Query: 154 ASVIIENEGKLEREK-KNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVEN 212
              I E E + ERE+ K  + E++ +    + K    Q E + ++    +K  E      
Sbjct: 501 PEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERK 560

Query: 213 YKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEP 254
            ++    + + E E +   ++    + + +K R K   ++EP
Sbjct: 561 QEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEP 602



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 36/195 (18%), Positives = 77/195 (39%), Gaps = 9/195 (4%)

Query: 85  RDFDALNERIQKETTEQRALEEQEKQERAERVRKLREER-----KQNEQEQAELDGTSGL 139
           R+ +   +R +++  E+   +EQEKQ   E+ RK  +E+     K+ E+E  ++      
Sbjct: 527 REKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKE 586

Query: 140 AELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNH 199
            EL+ E     + I       E  +E+++      K+ +    +      + E    V+ 
Sbjct: 587 CELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHE 646

Query: 200 NGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDD 259
              ++      +     L+   K   ++  P  +    + K ++ + ++   V P  +  
Sbjct: 647 TEPESGS----QPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVPS 702

Query: 260 CAPESPTPPPPPPPV 274
               S  PPPP  P+
Sbjct: 703 QPSSSTVPPPPHRPL 717



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 54/260 (20%), Positives = 103/260 (39%), Gaps = 38/260 (14%)

Query: 86  DFDALNERIQKETTEQ-RALEEQEKQERAERVRKLRE-----------------ERKQNE 127
           +  A  ER +K   E+ R +EEQ K   AE++++L E                 ER++  
Sbjct: 454 EISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKER 513

Query: 128 QEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKME 187
           + + EL+      E + E     +       E E +LE+E++ Q+ E + +    K K  
Sbjct: 514 EREKELE-----KEQEQEREKEREKDRERQQEKEKELEKEQEKQR-EMEKERKQEKEKEL 567

Query: 188 HEQIETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLR-- 245
             Q E + ++    ++  E  L E  +E L ++++  +    P +E    +    K    
Sbjct: 568 ERQKEKEKELQKMKEQEKECEL-EKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEP 626

Query: 246 ------MKRNHRVEPLNIDDCAPESPTPPPPPPPVGWGTPKVTRLP-----KLEPLGETH 294
                   R+ +     + +  PES + P P    G+       LP     + E + +  
Sbjct: 627 VFTRQDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQ 686

Query: 295 HNDFYRKPLPPLAVPQRPNS 314
                ++ + P  VP +P+S
Sbjct: 687 WQQQQQQGVLPQTVPSQPSS 706



 Score = 37.0 bits (84), Expect = 0.023
 Identities = 50/235 (21%), Positives = 90/235 (38%), Gaps = 19/235 (8%)

Query: 88   DALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPT 147
            DA N+    E  +Q+ L   ++    ER+  +  +  +        + T    E   EP+
Sbjct: 888  DANNQSACFEAPDQKTLSAPQE----ERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPS 943

Query: 148  NPFQPIASVIIENEGKLEREKKNQKME---KDSDGCHLKHKMEHEQIETQGQVNHNGQKN 204
                 + S  I+++  +ER ++  K E   + S+G     K+   + ET+     +  + 
Sbjct: 944  AGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPK-PEKVYKSKSETRWGPRPSSNRR 1002

Query: 205  NEFG-----LVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDD 259
             E            K+ + + +K E E  R   E    +K T+K+ +K   + E  ++  
Sbjct: 1003 EEVNDRPVRRSGPIKKPVLRDMKEERE-QRKEKEGEKAEKVTEKVVVKPE-KTEKKDL-- 1058

Query: 260  CAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRPNS 314
              P  P PP PP P+   +      P+ E    T      +KP      P  P S
Sbjct: 1059 --PPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVS 1111



 Score = 28.9 bits (63), Expect = 6.4
 Identities = 35/171 (20%), Positives = 69/171 (40%), Gaps = 11/171 (6%)

Query: 85   RDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDP 144
            R FD   ER +++   +     Q+K  R  R+R+     K NE      +GT  +  +  
Sbjct: 1411 RKFDPARERPRRQRPTRPP--RQDKPPRFRRLREREAASKSNEVVAVPTNGT--VNNVAQ 1466

Query: 145  EPTNPFQPIA-SVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQK 203
            EP N    I+ +   +   +   ++ N++ E  S+      + E ++   +   + N Q 
Sbjct: 1467 EPVNTLGDISGNKTPDLSNQNSSDQANEEWETASESSDFNERRERDE---KKNADLNAQT 1523

Query: 204  NNEFG--LVENYKEALTQQLKNEDETDRPSLESANGKKKT-KKLRMKRNHR 251
              + G  ++   +E   +   ++   DR +    NG  K+ +     RN R
Sbjct: 1524 VVKVGENVLPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNER 1574


>gi|15149463 caldesmon 1 isoform 4 [Homo sapiens]
          Length = 558

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 40/153 (26%), Positives = 70/153 (45%), Gaps = 13/153 (8%)

Query: 96  KETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIAS 155
           K TT    +E  ++    ER+ +  E R++  QE  E        E DP  T+    + S
Sbjct: 74  KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ-----KEFDPTITDASLSLPS 128

Query: 156 VIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYKE 215
             ++N+       +N+  EK+      + + E E+ ET   V  + QKN+     EN KE
Sbjct: 129 RRMQND-----TAENETTEKEEKSESRQERYEIEETET---VTKSYQKNDWRDAEENKKE 180

Query: 216 ALTQQLKNEDETDRPSLESANGKKKTKKLRMKR 248
              ++ + E++  R S+    G++K  K++ KR
Sbjct: 181 DKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKR 213



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 48/221 (21%), Positives = 86/221 (38%), Gaps = 45/221 (20%)

Query: 91  NERIQKETTEQRALEEQEKQE------RAERVRKLREERKQNEQEQAELDGTSGLAELDP 144
           + R+Q +T E    E++EK E        E    + +  ++N+   AE    +   + + 
Sbjct: 128 SRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE---ENKKEDKEK 184

Query: 145 EPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKN 204
           E     +P    I EN+G+ +  K   K EK  +    K   + E+I+ + ++  + +  
Sbjct: 185 EEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQED---KPTFKKEEIKDE-KIKKDKEPK 240

Query: 205 NEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEP---LNIDDCA 261
            E     + K+  T+            ++S NG+  T KL+   N    P    ++D   
Sbjct: 241 EEVKSFMDRKKGFTE------------VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 288

Query: 262 PESPTPPPPPPPVGWGTPKVTRLPKLEPL----GETHHNDF 298
            E             G P+V    +LE L    GET   +F
Sbjct: 289 AE-------------GAPQVEAGKRLEELRRRRGETESEEF 316



 Score = 31.6 bits (70), Expect = 0.99
 Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 8/86 (9%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           +R ++E  +++  EE+EK+   E + + R E  +  Q+  E DG S     D +P   F 
Sbjct: 349 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE-DGLSD----DKKPFKCFT 403

Query: 152 PIASVIIENEGKLEREKKNQKMEKDS 177
           P  S +   E     E  N+ ++K S
Sbjct: 404 PKGSSLKIEE---RAEFLNKSVQKSS 426



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 35/154 (22%), Positives = 69/154 (44%), Gaps = 19/154 (12%)

Query: 96  KETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIAS 155
           K+  ++ ALE +E +++ E  RK+ EE +Q  +++   +    L E + E     + I  
Sbjct: 320 KQKQQEAALELEELKKKREERRKVLEEEEQRRKQE---EADRKLRE-EEEKRRLKEEI-- 373

Query: 156 VIIENEGKLEREKKNQKMEKDSDGCHLK------HKMEHEQIETQGQ-VNHNGQKNNEFG 208
                  + E  +K QKM +D      K       K    +IE + + +N + QK++  G
Sbjct: 374 ----ERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSS--G 427

Query: 209 LVENYKEALTQQLKNEDETDRPSLESANGKKKTK 242
           +   ++ A+  ++ +  E    ++E     K TK
Sbjct: 428 VKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTK 461


>gi|15149467 caldesmon 1 isoform 3 [Homo sapiens]
          Length = 564

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 40/153 (26%), Positives = 70/153 (45%), Gaps = 13/153 (8%)

Query: 96  KETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIAS 155
           K TT    +E  ++    ER+ +  E R++  QE  E        E DP  T+    + S
Sbjct: 80  KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ-----KEFDPTITDASLSLPS 134

Query: 156 VIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYKE 215
             ++N+       +N+  EK+      + + E E+ ET   V  + QKN+     EN KE
Sbjct: 135 RRMQND-----TAENETTEKEEKSESRQERYEIEETET---VTKSYQKNDWRDAEENKKE 186

Query: 216 ALTQQLKNEDETDRPSLESANGKKKTKKLRMKR 248
              ++ + E++  R S+    G++K  K++ KR
Sbjct: 187 DKEKEEEEEEKPKRGSIGENQGEEKGTKVQAKR 219



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 48/221 (21%), Positives = 86/221 (38%), Gaps = 45/221 (20%)

Query: 91  NERIQKETTEQRALEEQEKQE------RAERVRKLREERKQNEQEQAELDGTSGLAELDP 144
           + R+Q +T E    E++EK E        E    + +  ++N+   AE    +   + + 
Sbjct: 134 SRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE---ENKKEDKEK 190

Query: 145 EPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKN 204
           E     +P    I EN+G+ +  K   K EK  +    K   + E+I+ + ++  + +  
Sbjct: 191 EEEEEEKPKRGSIGENQGEEKGTKVQAKREKLQED---KPTFKKEEIKDE-KIKKDKEPK 246

Query: 205 NEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEP---LNIDDCA 261
            E     + K+  T+            ++S NG+  T KL+   N    P    ++D   
Sbjct: 247 EEVKSFMDRKKGFTE------------VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 294

Query: 262 PESPTPPPPPPPVGWGTPKVTRLPKLEPL----GETHHNDF 298
            E             G P+V    +LE L    GET   +F
Sbjct: 295 AE-------------GAPQVEAGKRLEELRRRRGETESEEF 322



 Score = 31.6 bits (70), Expect = 0.99
 Identities = 24/86 (27%), Positives = 41/86 (47%), Gaps = 8/86 (9%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           +R ++E  +++  EE+EK+   E + + R E  +  Q+  E DG S     D +P   F 
Sbjct: 355 QRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE-DGLSD----DKKPFKCFT 409

Query: 152 PIASVIIENEGKLEREKKNQKMEKDS 177
           P  S +   E     E  N+ ++K S
Sbjct: 410 PKGSSLKIEE---RAEFLNKSVQKSS 432



 Score = 28.5 bits (62), Expect = 8.4
 Identities = 35/154 (22%), Positives = 69/154 (44%), Gaps = 19/154 (12%)

Query: 96  KETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIAS 155
           K+  ++ ALE +E +++ E  RK+ EE +Q  +++   +    L E + E     + I  
Sbjct: 326 KQKQQEAALELEELKKKREERRKVLEEEEQRRKQE---EADRKLRE-EEEKRRLKEEI-- 379

Query: 156 VIIENEGKLEREKKNQKMEKDSDGCHLK------HKMEHEQIETQGQ-VNHNGQKNNEFG 208
                  + E  +K QKM +D      K       K    +IE + + +N + QK++  G
Sbjct: 380 ----ERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSS--G 433

Query: 209 LVENYKEALTQQLKNEDETDRPSLESANGKKKTK 242
           +   ++ A+  ++ +  E    ++E     K TK
Sbjct: 434 VKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTK 467


>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
          Length = 732

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 43/165 (26%), Positives = 72/165 (43%), Gaps = 31/165 (18%)

Query: 93  RIQKETTEQRALE--EQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPF 150
           R+QKE  EQ  +E  EQ++ ER E  RK  EER + E+E  + +                
Sbjct: 412 RLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEE--------------- 456

Query: 151 QPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLV 210
                   E + + E +KK +  EK   G   K K E E +  + Q     Q+  E  ++
Sbjct: 457 --------ERKRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQ----EQEKQEKAMI 504

Query: 211 ENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPL 255
           E  KEA   + K  +  ++  LE      + ++ R++R  R++ +
Sbjct: 505 EKQKEA--AETKAREVAEQMRLEREQIMLQIEQERLERKKRIDEI 547



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 16/59 (27%)

Query: 92  ERIQKETTEQR-----ALEEQ--EKQERA---------ERVRKLREERKQNEQEQAELD 134
           +R+ KE  E+R     A E+Q  EKQ+RA         ER RKL E+R++ +Q++A ++
Sbjct: 55  QRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVE 113


>gi|187761324 shootin1 isoform a [Homo sapiens]
          Length = 631

 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 48/194 (24%), Positives = 84/194 (43%), Gaps = 30/194 (15%)

Query: 95  QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIA 154
           +K       LE+++  E+  RV  L  E  + E+ Q  L       EL+ +     +  A
Sbjct: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVE--EYEEMQVNL-------ELEKDLRKKAESFA 235

Query: 155 SVIIENEGKLEREKK---------NQKMEKDSDGCHLKHKMEHEQIETQGQVNH-NGQKN 204
             +   + KL+R+            Q ++   +   L  ++E E+I+ Q +V     Q  
Sbjct: 236 QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLE 295

Query: 205 NE--FGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLN--IDDC 260
           NE     + N K+ L  +L  ED+ +   L+  N ++K + L+    H V+ L   ++  
Sbjct: 296 NETLHKEIHNLKQQL--ELLEEDKKEL-ELKYQNSEEKARNLK----HSVDELQKRVNQS 348

Query: 261 APESPTPPPPPPPV 274
               P PPPPPPP+
Sbjct: 349 ENSVPPPPPPPPPL 362


>gi|50511340 shootin1 isoform b [Homo sapiens]
          Length = 456

 Score = 45.4 bits (106), Expect = 7e-05
 Identities = 48/194 (24%), Positives = 84/194 (43%), Gaps = 30/194 (15%)

Query: 95  QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIA 154
           +K       LE+++  E+  RV  L  E  + E+ Q  L       EL+ +     +  A
Sbjct: 185 EKTVLNSEVLEQRKVLEKCNRVSMLAVE--EYEEMQVNL-------ELEKDLRKKAESFA 235

Query: 155 SVIIENEGKLEREKK---------NQKMEKDSDGCHLKHKMEHEQIETQGQVNH-NGQKN 204
             +   + KL+R+            Q ++   +   L  ++E E+I+ Q +V     Q  
Sbjct: 236 QEMFIEQNKLKRQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLE 295

Query: 205 NE--FGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLN--IDDC 260
           NE     + N K+ L  +L  ED+ +   L+  N ++K + L+    H V+ L   ++  
Sbjct: 296 NETLHKEIHNLKQQL--ELLEEDKKEL-ELKYQNSEEKARNLK----HSVDELQKRVNQS 348

Query: 261 APESPTPPPPPPPV 274
               P PPPPPPP+
Sbjct: 349 ENSVPPPPPPPPPL 362


>gi|68161546 misshapen/NIK-related kinase isoform 4 [Homo sapiens]
          Length = 1312

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 48/229 (20%), Positives = 91/229 (39%), Gaps = 50/229 (21%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           RI+++  E+R +EEQ+++ER +  RKL+E+ +Q   E                     Q 
Sbjct: 397 RIEEQKEERRRVEEQQRREREQ--RKLQEKEQQRRLED-------------------MQA 435

Query: 153 IASVIIENEGKLEREKKNQKMEKDSDGCHLKHKM--EHEQIET--QGQVNHNGQKNNEFG 208
           +       + + E+E K +++E+      L+ ++  EH  +++  Q Q     QK  +  
Sbjct: 436 LRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQ 495

Query: 209 LVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTPP 268
           L+   ++ L    +  +  D+P+   A   ++  ++  ++N  +         PE P P 
Sbjct: 496 LLPGDRKPLYHYGRGMNPADKPAW--AREVEERTRMNKQQNSPLAKSKPGSTGPEPPIPQ 553

Query: 269 PPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRPNSDAH 317
             P P G             PL +T          PP+  P  P    H
Sbjct: 554 ASPGPPG-------------PLSQT----------PPMQRPVEPQEGPH 579



 Score = 32.3 bits (72), Expect = 0.58
 Identities = 32/158 (20%), Positives = 67/158 (42%), Gaps = 18/158 (11%)

Query: 94  IQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPI 153
           I+ + TE++     + ++  +R RK R E+++ E E       SG  E D       +P 
Sbjct: 289 IRDQPTERQV--RIQLKDHIDRSRKKRGEKEETEYEY------SGSEEEDDSHGEEGEPS 340

Query: 154 ASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENY 213
           + + +  E  L RE    + E  S+   LK + + +Q + +    H          +++ 
Sbjct: 341 SIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAH----------IKHL 390

Query: 214 KEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
                ++++ + E  R   E    +++ +KL+ K   R
Sbjct: 391 LHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQR 428


>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
          Length = 675

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 42/151 (27%), Positives = 72/151 (47%), Gaps = 17/151 (11%)

Query: 103 ALEEQEKQERAERVRKLREE-RKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENE 161
           + EE E+Q R +  RK  EE R++ E+E+           +D +    ++ I+   +   
Sbjct: 313 SFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFL-TP 371

Query: 162 GKLE---REKKNQKMEKDSDGCH--LKHKMEHEQIETQG---QVNHNGQKNNEFGLVENY 213
           GKLE    E   QKME++        KHK+E E+ E +    ++    ++N  FGL   Y
Sbjct: 372 GKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREY 431

Query: 214 KEALTQQLKNEDETDRPSLESANGKKKTKKL 244
           +E +  +LK        S+++ N K K +K+
Sbjct: 432 EELI--KLKRSG-----SIQAKNLKSKFEKI 455


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 42/188 (22%), Positives = 80/188 (42%), Gaps = 10/188 (5%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           ER++K   E + L EQ +QER E+ R+ +E R+Q  +EQ   +    LAE +        
Sbjct: 673 ERLRK-AAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE-- 729

Query: 152 PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVE 211
                 ++ E +L+  +K  +++K+     L+ K + E+ +   +     ++  +     
Sbjct: 730 -----RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784

Query: 212 NYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTPPPPP 271
              +AL   +  +         +  G +   K+    N+ ++ LN DD   +   P  P 
Sbjct: 785 GASKALNVTVDVQSPACTSYQMTPQGHRAPPKIN-PDNYGMD-LNSDDSTDDEAHPRKPI 842

Query: 272 PPVGWGTP 279
           P    GTP
Sbjct: 843 PTWARGTP 850



 Score = 33.5 bits (75), Expect = 0.26
 Identities = 34/174 (19%), Positives = 74/174 (42%), Gaps = 12/174 (6%)

Query: 80  LHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQ--EQAELDGTS 137
           L  + R  +A   R QK   ++R   E+ K +R ER+RK+ + R++ EQ  E+ +     
Sbjct: 542 LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 601

Query: 138 GLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQV 197
             A++D +             + E   E + K +   K  +    + K E E    +   
Sbjct: 602 KFAQIDEKTEK---------AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652

Query: 198 NHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
               ++ ++  L++  KE   ++L+   E  R + +    +++ ++   +R  +
Sbjct: 653 QEEEERRHQ-ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 705


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 42/188 (22%), Positives = 80/188 (42%), Gaps = 10/188 (5%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           ER++K   E + L EQ +QER E+ R+ +E R+Q  +EQ   +    LAE +        
Sbjct: 669 ERLRK-AAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE-- 725

Query: 152 PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVE 211
                 ++ E +L+  +K  +++K+     L+ K + E+ +   +     ++  +     
Sbjct: 726 -----RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 780

Query: 212 NYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTPPPPP 271
              +AL   +  +         +  G +   K+    N+ ++ LN DD   +   P  P 
Sbjct: 781 GASKALNVTVDVQSPACTSYQMTPQGHRAPPKIN-PDNYGMD-LNSDDSTDDEAHPRKPI 838

Query: 272 PPVGWGTP 279
           P    GTP
Sbjct: 839 PTWARGTP 846



 Score = 33.5 bits (75), Expect = 0.26
 Identities = 34/174 (19%), Positives = 74/174 (42%), Gaps = 12/174 (6%)

Query: 80  LHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQ--EQAELDGTS 137
           L  + R  +A   R QK   ++R   E+ K +R ER+RK+ + R++ EQ  E+ +     
Sbjct: 538 LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 597

Query: 138 GLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQV 197
             A++D +             + E   E + K +   K  +    + K E E    +   
Sbjct: 598 KFAQIDEKTEK---------AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648

Query: 198 NHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
               ++ ++  L++  KE   ++L+   E  R + +    +++ ++   +R  +
Sbjct: 649 QEEEERRHQ-ELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 49/232 (21%), Positives = 83/232 (35%), Gaps = 30/232 (12%)

Query: 95  QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIA 154
           QKE   +R   E+ ++ER ER R  RE  ++   EQ +L+      E         +   
Sbjct: 153 QKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLER 212

Query: 155 SVIIENEGKLEREKKN-------QKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEF 207
              +E + +L+RE++        +++E++      + ++E EQ+E +       ++    
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWE------RERRISS 266

Query: 208 GLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLR----------MKRNHRVEPLNI 257
                  E     +  +     P L++A+   +T   +                  P   
Sbjct: 267 AAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQA 326

Query: 258 DDCAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVP 309
               P  P PPPPPP    G P     P L        N     P PP A P
Sbjct: 327 SVALPPPPGPPPPPPLPSTGPPPPPPPPPLP-------NQVPPPPPPPPAPP 371



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 14/41 (34%), Positives = 29/41 (70%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAE 132
           ER++++    R  +E++++ER ER+ + R+ER++ EQ + E
Sbjct: 214 ERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 21/66 (31%), Positives = 38/66 (57%), Gaps = 1/66 (1%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           ER ++   E++  +E+E+ ER ER R+ RE ++Q E+EQ E +    ++     P +   
Sbjct: 217 ERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSA-AAPASVET 275

Query: 152 PIASVI 157
           P+ SV+
Sbjct: 276 PLNSVL 281



 Score = 31.6 bits (70), Expect = 0.99
 Identities = 17/42 (40%), Positives = 29/42 (69%), Gaps = 1/42 (2%)

Query: 92  ERIQK-ETTEQRALEEQEKQERAERVRKLREERKQNEQEQAE 132
           ER+++ E  E++   ++E+QER ER R  R ER++ E+E+ E
Sbjct: 208 ERLERQERLERQERLDRERQERQERERLERLERERQERERQE 249


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 49/232 (21%), Positives = 83/232 (35%), Gaps = 30/232 (12%)

Query: 95  QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIA 154
           QKE   +R   E+ ++ER ER R  RE  ++   EQ +L+      E         +   
Sbjct: 153 QKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLER 212

Query: 155 SVIIENEGKLEREKKN-------QKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEF 207
              +E + +L+RE++        +++E++      + ++E EQ+E +       ++    
Sbjct: 213 QERLERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWE------RERRISS 266

Query: 208 GLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLR----------MKRNHRVEPLNI 257
                  E     +  +     P L++A+   +T   +                  P   
Sbjct: 267 AAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQA 326

Query: 258 DDCAPESPTPPPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVP 309
               P  P PPPPPP    G P     P L        N     P PP A P
Sbjct: 327 SVALPPPPGPPPPPPLPSTGPPPPPPPPPLP-------NQVPPPPPPPPAPP 371



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 14/41 (34%), Positives = 29/41 (70%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAE 132
           ER++++    R  +E++++ER ER+ + R+ER++ EQ + E
Sbjct: 214 ERLERQERLDRERQERQERERLERLERERQERERQEQLERE 254



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 21/66 (31%), Positives = 38/66 (57%), Gaps = 1/66 (1%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           ER ++   E++  +E+E+ ER ER R+ RE ++Q E+EQ E +    ++     P +   
Sbjct: 217 ERQERLDRERQERQERERLERLERERQERERQEQLEREQLEWERERRISSA-AAPASVET 275

Query: 152 PIASVI 157
           P+ SV+
Sbjct: 276 PLNSVL 281



 Score = 31.6 bits (70), Expect = 0.99
 Identities = 17/42 (40%), Positives = 29/42 (69%), Gaps = 1/42 (2%)

Query: 92  ERIQK-ETTEQRALEEQEKQERAERVRKLREERKQNEQEQAE 132
           ER+++ E  E++   ++E+QER ER R  R ER++ E+E+ E
Sbjct: 208 ERLERQERLERQERLDRERQERQERERLERLERERQERERQE 249


>gi|194097392 Golgi autoantigen, golgin subfamily a, 2 [Homo
           sapiens]
          Length = 1002

 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 50/221 (22%), Positives = 88/221 (39%), Gaps = 40/221 (18%)

Query: 59  SAISGYGKKIDKSIKKGLYWLLHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRK 118
           SA+S   KK D+  K+        + ++ DAL   + K T     L+ QEK E  E++R 
Sbjct: 273 SAVSTQQKKADRYNKE--------LTKERDALRLELYKNTQSNEDLK-QEKSELEEKLRV 323

Query: 119 LREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSD 178
           L  E+   +    EL     + EL             ++ +   + E    NQ++++  +
Sbjct: 324 LVTEKAGMQLNLEELQKKLEMTEL-------------LLQQFSSRCEAPDANQQLQQAME 370

Query: 179 GCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYKEALTQQLKNEDETDRPSL----ES 234
                   E  Q+E      H GQ       ++  ++   + LK E    R  +    E 
Sbjct: 371 --------ERAQLEA-----HLGQVMESVRQLQMERDKYAENLKGESAMWRQRMQQMSEQ 417

Query: 235 ANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTPPPPPPPVG 275
            +  ++ K+  M R   +E  ++ +   +   PPPP PP G
Sbjct: 418 VHTLREEKECSMSRVQELET-SLAELRNQMAEPPPPEPPAG 457



 Score = 33.1 bits (74), Expect = 0.34
 Identities = 39/161 (24%), Positives = 66/161 (40%), Gaps = 25/161 (15%)

Query: 101 QRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELD---PEPTNPFQPIASVI 157
           + A+  Q  Q+ +E+V  LREE++ +     EL+  + LAEL     EP  P  P     
Sbjct: 403 ESAMWRQRMQQMSEQVHTLREEKECSMSRVQELE--TSLAELRNQMAEPPPPEPPAGPSE 460

Query: 158 IENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNG-----QKNNEFGLVEN 212
           +E + + E E             HL+ ++E    + Q QV  N       +  E  L+E 
Sbjct: 461 VEQQLQAEAE-------------HLRKELEGLAGQLQAQVQDNEGLSRLNREQEERLLE- 506

Query: 213 YKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVE 253
             E   +    + E  R  LE+    + T    + +N  ++
Sbjct: 507 -LERAAELWGEQAEARRQILETMQNDRTTISRALSQNRELK 546



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 13/44 (29%), Positives = 27/44 (61%)

Query: 90  LNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAEL 133
           L +++Q++  + +A+ E  +QE  E   +L    +QN+Q +A+L
Sbjct: 646 LVDQLQQQEAQGKAVAEMARQELQETQERLEAATQQNQQLRAQL 689


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 42.4 bits (98), Expect = 6e-04
 Identities = 40/168 (23%), Positives = 76/168 (45%), Gaps = 19/168 (11%)

Query: 85  RDFDALNERIQKETTEQRALEEQE-KQERAERVRKLREERKQNEQEQAELDGTSGLAELD 143
           R+ +   ER +KE   +R  EE+E K+ R E+  K  EE+++ ++++ +  G +     +
Sbjct: 73  REKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKE 132

Query: 144 PEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQK 203
            E             + E + ERE+K ++ EK+ +    K K E +Q+         G+K
Sbjct: 133 RERKEE--------RKREERKERERKKEEREKERERKERK-KRERKQV---------GEK 174

Query: 204 NNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
             E    E  +    ++ + E + +R   E    KK+ KK   ++  R
Sbjct: 175 EEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKER 222



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 32/157 (20%), Positives = 68/157 (43%), Gaps = 35/157 (22%)

Query: 95  QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIA 154
           +KE  ++R  E + K+ER ER ++ RE  K+ ++E+ + +                    
Sbjct: 48  RKEGKKER--ESERKKERREREKRKREREKERKRERGKKEKKG----------------- 88

Query: 155 SVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENYK 214
                   K ERE+K ++ EK++     K K + ++ + +G+ +  G++           
Sbjct: 89  -----ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER-------- 135

Query: 215 EALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
               ++ K E+  +R   +    K++ +K R KR  +
Sbjct: 136 ---KEERKREERKERERKKEEREKERERKERKKRERK 169



 Score = 38.5 bits (88), Expect = 0.008
 Identities = 27/112 (24%), Positives = 51/112 (45%), Gaps = 7/112 (6%)

Query: 93  RIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQP 152
           R  KE  E+   EE++++ER ER RK  E  K+ E+++ +      + E + E     + 
Sbjct: 125 RTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER- 183

Query: 153 IASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKN 204
                 +   K ER +K +K E++      + K   ++ E + +   + Q N
Sbjct: 184 ------KERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTN 229



 Score = 36.6 bits (83), Expect = 0.031
 Identities = 34/148 (22%), Positives = 60/148 (40%), Gaps = 15/148 (10%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           E+ +K+  ++R    +E +ER  +  + REERK+ E+++ E +      E          
Sbjct: 113 EKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQV- 171

Query: 152 PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVE 211
                    E + ER++K +K  K  +    + K E E+ E + +     +K       E
Sbjct: 172 --------GEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKE------E 217

Query: 212 NYKEALTQQLKNEDETDRPSLESANGKK 239
             KE    +  N  E +R   E    KK
Sbjct: 218 RKKERQKDRQTNWREKERGKRERKERKK 245


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 38/167 (22%), Positives = 73/167 (43%), Gaps = 24/167 (14%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           ER ++   +++  E+Q K+ R +  RK ++E+K+ E++Q       G  E   +     +
Sbjct: 70  ERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQ------RGRRERKKKKERKER 123

Query: 152 PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVE 211
                  E E K  RE+K +K  K       K + E ++ + +G+     +K       +
Sbjct: 124 -------ERENKQRRERKRKKRRKK------KRRKERKREKERGKRERKRKKRK-----K 165

Query: 212 NYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNID 258
             +E   ++ + E + +R   E    KK+ KK R K+  R +    D
Sbjct: 166 EEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTD 212



 Score = 35.0 bits (79), Expect = 0.089
 Identities = 30/145 (20%), Positives = 62/145 (42%), Gaps = 1/145 (0%)

Query: 92  ERIQKETTE-QRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPF 150
           E+ +KE  E +R   ++EK++R  + R  RE +K+ E+++ E +          +     
Sbjct: 83  EKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKK 142

Query: 151 QPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLV 210
           +       +  GK ER++K +K E+         K   ++ E + +     ++  E    
Sbjct: 143 RRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKK 202

Query: 211 ENYKEALTQQLKNEDETDRPSLESA 235
           +  K+      + + +  RP  ESA
Sbjct: 203 KERKKDRKTDRQTDSQVFRPLRESA 227



 Score = 34.7 bits (78), Expect = 0.12
 Identities = 33/158 (20%), Positives = 69/158 (43%), Gaps = 14/158 (8%)

Query: 94  IQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPI 153
           I K  T++ +  ++E++ER +R R+  +ERK+   ++ +          + E     +  
Sbjct: 25  ISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKER-- 82

Query: 154 ASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVENY 213
                E + K  REK+ +K +K+      K K E +Q   + +     +K  E    +  
Sbjct: 83  -----EKQRKERREKERRKRKKE------KKKRERKQRGRRERKKKKERKERERENKQRR 131

Query: 214 KEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHR 251
           +    ++ K +   +R   E   GK++ K+ + K+  R
Sbjct: 132 ERKRKKRRKKKRRKER-KREKERGKRERKRKKRKKEER 168


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 42.0 bits (97), Expect = 7e-04
 Identities = 39/186 (20%), Positives = 80/186 (43%), Gaps = 44/186 (23%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           +RI+++  ++R LEEQ+++ER  R ++ RE+R++ ++E+  L+      EL+        
Sbjct: 397 KRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLE------ELERRRK---- 446

Query: 152 PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNEFGLVE 211
                  E E +   E++ +++E++ +  +++ ++E EQ                     
Sbjct: 447 -------EEEERRRAEEEKRRVEREQE--YIRRQLEEEQ--------------------- 476

Query: 212 NYKEALTQQLKNED----ETDRPSLESANGKKKTKKLRMKRNHRVEPLNIDDCAPESPTP 267
            + E L QQL  E     E     +E     ++ ++   +    +  L  D   P     
Sbjct: 477 RHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHS 536

Query: 268 PPPPPP 273
             PPPP
Sbjct: 537 QQPPPP 542


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 24/112 (21%), Positives = 63/112 (56%), Gaps = 9/112 (8%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           +RI+++  ++R LEEQ+++ER  R ++ RE+R++ ++E+  L+      + + E      
Sbjct: 397 KRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR--- 453

Query: 152 PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQK 203
                  E + ++ERE++  + + + +  HL+  ++ + ++ Q  + H+ ++
Sbjct: 454 -----AEEEKRRVEREQEYIRRQLEEEQRHLE-VLQQQLLQEQAMLLHDHRR 499



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 44/194 (22%), Positives = 81/194 (41%), Gaps = 39/194 (20%)

Query: 83  IARDFDALNERIQKETTE----QRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSG 138
           + RDF  L +   KE +E    Q+ L+EQ+ +E+ E  R+L  ER++  ++Q E      
Sbjct: 352 LRRDFLRLQQE-NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR-- 408

Query: 139 LAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVN 198
                              +E + + ERE + Q+ E++      + K   E++E + +  
Sbjct: 409 -------------------LEEQQRREREARRQQ-EREQRRREQEEKRRLEELERRRKEE 448

Query: 199 HNGQK-NNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNI 257
              ++   E   VE  +E + +QL+ E       LE    +   ++  +  +HR      
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLEEEQR----HLEVLQQQLLQEQAMLLHDHRRP---- 500

Query: 258 DDCAPESPTPPPPP 271
               P+    PPPP
Sbjct: 501 ---HPQHSQQPPPP 511


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 24/112 (21%), Positives = 63/112 (56%), Gaps = 9/112 (8%)

Query: 92  ERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQ 151
           +RI+++  ++R LEEQ+++ER  R ++ RE+R++ ++E+  L+      + + E      
Sbjct: 397 KRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR--- 453

Query: 152 PIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQK 203
                  E + ++ERE++  + + + +  HL+  ++ + ++ Q  + H+ ++
Sbjct: 454 -----AEEEKRRVEREQEYIRRQLEEEQRHLE-VLQQQLLQEQAMLLHDHRR 499



 Score = 34.3 bits (77), Expect = 0.15
 Identities = 44/194 (22%), Positives = 81/194 (41%), Gaps = 39/194 (20%)

Query: 83  IARDFDALNERIQKETTE----QRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSG 138
           + RDF  L +   KE +E    Q+ L+EQ+ +E+ E  R+L  ER++  ++Q E      
Sbjct: 352 LRRDFLRLQQE-NKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRR-- 408

Query: 139 LAELDPEPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVN 198
                              +E + + ERE + Q+ E++      + K   E++E + +  
Sbjct: 409 -------------------LEEQQRREREARRQQ-EREQRRREQEEKRRLEELERRRKEE 448

Query: 199 HNGQK-NNEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVEPLNI 257
              ++   E   VE  +E + +QL+ E       LE    +   ++  +  +HR      
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLEEEQR----HLEVLQQQLLQEQAMLLHDHRRP---- 500

Query: 258 DDCAPESPTPPPPP 271
               P+    PPPP
Sbjct: 501 ---HPQHSQQPPPP 511


>gi|57863314 vacuolar protein sorting 37C [Homo sapiens]
          Length = 355

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 55/233 (23%), Positives = 93/233 (39%), Gaps = 47/233 (20%)

Query: 97  ETTEQRALEE-QEKQERAERVRKLREERKQNEQEQAE----LDGTSGLAELDPEPTNPFQ 151
           ET + + L+E +E Q  +E + +L  E  + +  Q E    L     LAE + E   P +
Sbjct: 2   ETLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLE 61

Query: 152 PIASVIIENEGKLER-----EKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKNNE 206
              S + +   +L +     +++  K+EK S        ++  Q+E        G K   
Sbjct: 62  ISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVE--------GMK--- 110

Query: 207 FGLVENYKEALTQQLKNEDETDRPSLESANGKKKTKKLRMKRNHRVE-----PLNIDDCA 261
              +E   EA+ ++    +      LE+ +  +    LR  R  +++     P    + A
Sbjct: 111 ---IEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELA 167

Query: 262 PESPTP--PPPPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVPQRP 312
            ++P P  PPP  PV  GTP V                   +P PPLA+P  P
Sbjct: 168 GDAPPPRPPPPVRPVPQGTPPVVE----------------EQPQPPLAMPPYP 204


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
           sapiens]
          Length = 1341

 Score = 41.2 bits (95), Expect = 0.001
 Identities = 56/245 (22%), Positives = 94/245 (38%), Gaps = 41/245 (16%)

Query: 93  RIQKETTEQRALEEQEKQE--------RAERVRKLREERKQNEQEQAELDGTSGLAELDP 144
           R  K +   +  EE+E QE        RA+R  K  EE ++ E+E+ + +   G    D 
Sbjct: 235 RAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEG---DDE 291

Query: 145 EPTNPFQPIASVIIENEGKLEREKKNQKMEKDSDGCHLKHKMEHEQIETQGQVNHNGQKN 204
              +   PI     E   ++ R K  + M++           E E +E  G+   + ++ 
Sbjct: 292 GQKSREAPILKEFKEEGEEIPRVKPEEMMDERPK----TRSQEQEVLERGGRFTRSQEEA 347

Query: 205 NEFGLVENYKEALTQQLKNEDETDRPSLESANGKKKTK-----KLRMKRNHRVEPLNIDD 259
            +  L    +E   +     +E +R    S   K+K+K     +L   R         + 
Sbjct: 348 RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQ 407

Query: 260 CAPESPTPPP-------PPPPVGWGTPKVTRLPKLEPLGETHHNDFYRKPLPPLAVP-QR 311
            A E  TPPP        PPP     P++    ++EP+           P PP+ +    
Sbjct: 408 TASEEETPPPLLTKEASSPPP----HPQLHSEEEIEPM---------EGPAPPVLIQLSP 454

Query: 312 PNSDA 316
           PN+DA
Sbjct: 455 PNTDA 459



 Score = 30.8 bits (68), Expect = 1.7
 Identities = 21/81 (25%), Positives = 40/81 (49%), Gaps = 5/81 (6%)

Query: 98   TTEQRALEEQEKQERAERVRKLREERKQNEQEQAELDGTSGLAELDPEPTNPFQPIASVI 157
            T  Q   +E E+ ERA+   K R+E+++ EQ++ E +     AE +       +      
Sbjct: 1230 TDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKE-----AERERNRQLEREKRREHS 1284

Query: 158  IENEGKLEREKKNQKMEKDSD 178
             E + + ERE++  + ++D D
Sbjct: 1285 RERDRERERERERDRGDRDRD 1305



 Score = 29.6 bits (65), Expect = 3.7
 Identities = 16/57 (28%), Positives = 32/57 (56%), Gaps = 2/57 (3%)

Query: 76   LYWLLHVIARDFDALNERIQKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAE 132
            +YWL    ++      ER ++    ++  +EQE++E+ ER ++   ER++N Q + E
Sbjct: 1224 IYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEA--ERERNRQLERE 1278



 Score = 29.3 bits (64), Expect = 4.9
 Identities = 13/40 (32%), Positives = 23/40 (57%)

Query: 95   QKETTEQRALEEQEKQERAERVRKLREERKQNEQEQAELD 134
            +K   EQ   E++E+++ AER R  + ER++  +   E D
Sbjct: 1249 EKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERD 1288


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.131    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,226,025
Number of Sequences: 37866
Number of extensions: 892962
Number of successful extensions: 17520
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 406
Number of HSP's successfully gapped in prelim test: 638
Number of HSP's that attempted gapping in prelim test: 9498
Number of HSP's gapped (non-prelim): 5320
length of query: 321
length of database: 18,247,518
effective HSP length: 102
effective length of query: 219
effective length of database: 14,385,186
effective search space: 3150355734
effective search space used: 3150355734
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.