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Search of human proteins with 33519450
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33519450 NLR family, pyrin domain containing 9 [Homo
sapiens]
(991 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 2022 0.0
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 792 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 677 0.0
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 557 e-158
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 556 e-158
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 524 e-148
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 524 e-148
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 503 e-142
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 499 e-141
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 494 e-139
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 462 e-130
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 452 e-127
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 447 e-125
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 443 e-124
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 442 e-124
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 433 e-121
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 397 e-110
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 339 9e-93
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 339 9e-93
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 339 9e-93
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 337 4e-92
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 337 4e-92
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 241 3e-63
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 206 7e-53
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 199 1e-50
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 199 1e-50
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 199 1e-50
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 199 1e-50
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 199 1e-50
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 199 1e-50
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 2022 bits (5238), Expect = 0.0
Identities = 991/991 (100%), Positives = 991/991 (100%)
Query: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD
Sbjct: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
Query: 61 KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVP 120
KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVP
Sbjct: 61 KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVP 120
Query: 121 EHFYKETMKNEYKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFT 180
EHFYKETMKNEYKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFT
Sbjct: 121 EHFYKETMKNEYKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFT 180
Query: 181 FVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQLK 240
FVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQLK
Sbjct: 181 FVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQLK 240
Query: 241 ADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSE 300
ADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSE
Sbjct: 241 ADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSE 300
Query: 301 SEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEIN 360
SEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEIN
Sbjct: 301 SEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEIN 360
Query: 361 SQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGL 420
SQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGL
Sbjct: 361 SQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGL 420
Query: 421 SESEGVMWVGMRLLQRRGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRAS 480
SESEGVMWVGMRLLQRRGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRAS
Sbjct: 421 SESEGVMWVGMRLLQRRGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRAS 480
Query: 481 VVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAI 540
VVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAI
Sbjct: 481 VVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAI 540
Query: 541 AFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVEN 600
AFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVEN
Sbjct: 541 AFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVEN 600
Query: 601 IFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCK 660
IFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCK
Sbjct: 601 IFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCK 660
Query: 661 LRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELI 720
LRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELI
Sbjct: 661 LRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELI 720
Query: 721 LGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMY 780
LGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMY
Sbjct: 721 LGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMY 780
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL
Sbjct: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA
Sbjct: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK
Sbjct: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
Query: 961 ILMSVEEKIPHLTISHGPWIDEEYKIRGVLL 991
ILMSVEEKIPHLTISHGPWIDEEYKIRGVLL
Sbjct: 961 ILMSVEEKIPHLTISHGPWIDEEYKIRGVLL 991
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 792 bits (2046), Expect = 0.0
Identities = 413/986 (41%), Positives = 626/986 (63%), Gaps = 14/986 (1%)
Query: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
MA SFFSDFGL+WYL+EL+KEEF KFKE LKQ + ELK IPW E+KKAS+E++A LL
Sbjct: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
Query: 61 KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVP 120
KHY +QAW +TL +F +++RKDL K E Y+ H K+ F +W ++ +
Sbjct: 61 KHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIH 120
Query: 121 EHFYKETMKNEYKELNDAYT---AAARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKD 177
+F +E + E L+ + A + TV+++GP GIGKTTLL K+M+ W++ +++D
Sbjct: 121 LYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRD 180
Query: 178 RFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNL 237
RF + F+ E+ + TSL +L+SR+WP+ + I +I SQPER+LF++D FE+L+ L
Sbjct: 181 RFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGL 240
Query: 238 -QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
+ +DL D +++P+ ++LSSLL+KKMLPE+SLLIA+ + ++ + ++ +
Sbjct: 241 NEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPR 300
Query: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
GF+ES++ YF FF + +A++ FN VR++ LF +C P CW++CT +KQ +++G+D
Sbjct: 301 GFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKD 360
Query: 357 LEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLR 416
L + Q+TT +Y+SF+ +F P + +LK+LC+LAAEG+WT TF F DLR
Sbjct: 361 LALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLR 420
Query: 417 RNGLSESEGVMWVGMRLLQRRGD---CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSI 473
RNG+ +++ +G ++L + G+ + F+H+CIQEFCAA+FYLLK D P+PA+ +
Sbjct: 421 RNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCV 480
Query: 474 TQLVRASVVQPQTL-LTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQ 532
+L+ A+ + + +G F+ G+ ++ L+ FGF LS+++KQ+I QCL+SL +
Sbjct: 481 QELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGE 540
Query: 533 CEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLT 592
+ + +F LFE Q+ FV + +N +E +I + LV++++CLK+C L
Sbjct: 541 RGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLR 600
Query: 593 TLRMCVENIFP--DDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAIL 650
L V+N+F D+ SDY+ L+ W +CS+ T+ + + L +++++L + +
Sbjct: 601 KLCFSVQNVFKKEDEHSSTSDYS--LICWHHICSVLTTSGHLRELQVQDSTLSESTFVTW 658
Query: 651 CKALAQPVCKLRKLIFTSVYF-GHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETL 709
C L P C+L+KL +V F G LF+ + + P LK LS T LS+ DIR LC+ L
Sbjct: 659 CNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDAL 718
Query: 710 KHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHS 769
+P ++EL L C +S CE +A +L N KL +L++ N L D G+ LLCEAL
Sbjct: 719 NYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSP 777
Query: 770 HCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCS 829
L LML +C L+ C+ ISE+LL +KS+ LDL +N L+D G+ +LC ALKHP C
Sbjct: 778 DTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCC 837
Query: 830 IRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLEC 889
+ L L+ CF+T+ C+D+A+ LI N LK L++G NEIGD GV+ LC AL H C+LE
Sbjct: 838 LDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEI 897
Query: 890 LGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
LGL+ C +T CC D+A+ L KTL+ LNL LD VVVLCEAL HP+CALQ+LGL
Sbjct: 898 LGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
Query: 950 HKSGFDEETQKILMSVEEKIPHLTIS 975
K+ FDEETQ +L + EE+ P+LTI+
Sbjct: 958 RKTDFDEETQALLTAEEERNPNLTIT 983
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 677 bits (1747), Expect = 0.0
Identities = 377/993 (37%), Positives = 577/993 (58%), Gaps = 42/993 (4%)
Query: 2 AESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDK 61
+ SFF DFGLL YL+EL KEE FK LK+ +E E PW E+KKA +ED+A L+ K
Sbjct: 6 SSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEP-EHGLTPWNEVKKARREDLANLMKK 64
Query: 62 HYPGKQAWEVTLNLFLQINRKDLWTKAQEEMR---NKLNP-------------------- 98
+YPG++AW V+L +F ++N KDL +A+EE+ + P
Sbjct: 65 YYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGT 124
Query: 99 -YRKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA----AARRHTVVLEGP 153
YR +KE F + W+K++ PE F+ + + K L + A+ VVL+G
Sbjct: 125 EYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGA 184
Query: 154 DGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKI 213
G+GKTTL+RK MLDWAEG+L++ RF +VF+LN E+N + E S +L+S+DWP + I
Sbjct: 185 AGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPI 244
Query: 214 EDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIILSSLLQKKMLPESSLL 272
E+I QP +LFI+D F++L F + + L +DW Q P+ ++SSLL+K MLPE+SLL
Sbjct: 245 EEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLL 304
Query: 273 IALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFI 332
+ ++ +L++ ++LLG SE ++ Y FF +K A+KVF+ ++ N LF
Sbjct: 305 VTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFS 364
Query: 333 LCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARL 392
+C P CW CTC+KQ++E+G D+ + Q TT L+ +++++F P N+A+L
Sbjct: 365 MCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQL 424
Query: 393 KSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRRGD---CFAFMHLCIQ 449
+ LC +AA+GIWT T+VF +LRR GL++S+ ++ ++Q+ + C+ F HL +Q
Sbjct: 425 RRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQ 484
Query: 450 EFCAAMFYLLKRPKDDPNPAIGSITQL--VRASVVQPQTLLTQVGIFMFGISTEEIVSML 507
EF AAMFY+LK + NP+ L + S LTQ+ F+FG+ E+ V L
Sbjct: 485 EFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQL 544
Query: 508 ETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEE 567
E +F +S +K ++ QC+E L + + F ELF L+ETQ+K F+++ M F +
Sbjct: 545 ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPK 604
Query: 568 VFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDDSGCIS------DYNEKLVYWRE 621
V I I HL+++SFCLKHC+ L T+R+ V +F S D + W++
Sbjct: 605 VAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQD 664
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHD-SELFKA 680
LCS+ TN++ + LD+ +++LD ++ IL L P CKL+KL+ + F ++ +
Sbjct: 665 LCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTS 724
Query: 681 VLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLAC 740
++HN +L L L G+ + + ++ LCE LKHP CK++ L L C+++ C +I++ L
Sbjct: 725 LIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIR 784
Query: 741 NSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKS 800
+ L L+L N L D+G+ LLCEAL+H C LERL L C LT C+ +S L+ +K
Sbjct: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
Query: 801 LSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKT 860
L+ L L N L D GV + AL+H C+++ L L C TS S + ++ L+ N L
Sbjct: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
Query: 861 LKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNL 920
L LG N + D GV+ LC +HP C L+ L L C +T ACC D+A+ ++ LRSL+L
Sbjct: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
Query: 921 DWIALDADAVVVLCEALSHPDCALQMLGLHKSG 953
L D V +LC+AL +P+C +Q LGL G
Sbjct: 965 GNNDLQDDGVKILCDALRYPNCNIQRLGLEYCG 997
Score = 147 bits (372), Expect = 4e-35
Identities = 91/254 (35%), Positives = 135/254 (53%), Gaps = 5/254 (1%)
Query: 732 EDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSI 791
+D+ SVL N L+ L L + L M +L L+H +C L++L+L + C I
Sbjct: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
Query: 792 SEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAV 851
S L+ +K+L LDL + + DNGV SLC ALKHP C ++ L L C LT C +I+
Sbjct: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
Query: 852 LICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIA 911
LI + L L L N + D GV+ LC AL+HP C LE L L++C +T A C+ ++ ALI+
Sbjct: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
Query: 912 CKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSV---EEK 968
K L L L L V ++ +AL H C L+ L L + F + + L + +
Sbjct: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
Query: 969 IPHLTISHGPWIDE 982
+ HL + W+ +
Sbjct: 902 LTHLDLGSN-WLQD 914
Score = 36.2 bits (82), Expect = 0.16
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
C D+ + L + LR L+L LD A+ +L L HP+C LQ L L F + Q
Sbjct: 661 CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQD 720
Query: 961 ILMSV--EEKIPHLTI 974
I S+ + + HL +
Sbjct: 721 ISTSLIHNKNLMHLDL 736
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 557 bits (1435), Expect = e-158
Identities = 339/1005 (33%), Positives = 542/1005 (53%), Gaps = 28/1005 (2%)
Query: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
MAES +DF LLWYL+ L +EF FK+ L + + F+L P ++ +KE++A +L
Sbjct: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQM---TKEELANVLP 57
Query: 61 KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVP 120
Y G+ W + ++F + ++DL K + M+ F L WE T
Sbjct: 58 ISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFH 117
Query: 121 EHFYKETMKNEYKELNDAYTA----AARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWK 176
F+++ + + L AY + +A V L G GKT ++ +L W +G +W+
Sbjct: 118 YKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQ 177
Query: 177 DRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFN 236
+ ++V L E+N + +SL EL+++DWP+ I DI S P+++LFI++ + ++F
Sbjct: 178 NMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFE 237
Query: 237 LQL-KADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKL 295
L + ++ L + Q+ P+P++L SLL++KM P LI+ L+
Sbjct: 238 LNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTT 297
Query: 296 LGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGE 355
L S +++ YF+ FF ++ +A V ++ L LC CW+ CT +K+++++G
Sbjct: 298 LQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGR 357
Query: 356 DLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDL 415
D ++ Q T L+A FL + + + + LK LC LAA G++ T FS DL
Sbjct: 358 DFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGEDL 417
Query: 416 RRNGLSESEGVMWVGMRLL---QRRGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGS 472
R G +E++ + +L D + F+HL +QEFC A+ +L+ P N I S
Sbjct: 418 RCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAVP----NYLIPS 473
Query: 473 ITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGF--PLSKDLKQEITQCLESL 530
++ + Q QV F+FG+ +LETSFG+ P+ K ++ L
Sbjct: 474 GSREYKEKREQYSDF-NQVFTFIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYMKHL 532
Query: 531 SQCEADREAIAFQ-ELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQ 589
+ D E + LF L+E +E+EFV +++ EV +Y+ + + ++++ +CL +C
Sbjct: 533 DR---DPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDYCC 589
Query: 590 HLTTLRMCVENIFPDDSGCI---SDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPS 646
HL TL++ V+ IF + I + + LVYWRE+CS+F T ++ + L + + L+ S
Sbjct: 590 HLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGIS 649
Query: 647 LAILCKALAQPVCKLR--KLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRH 704
IL KAL CKLR KL + S G + +L KA+ N L LS+ TS+S +
Sbjct: 650 ERILSKALEHSSCKLRTLKLSYVSTASGFE-DLLKALARNRSLTYLSINCTSISLNMFSL 708
Query: 705 LCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCE 764
L + L P C+I L L KCD+ + CE+IAS+L L+ L+L NPLR +GM +LC+
Sbjct: 709 LHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCD 768
Query: 765 ALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALK 824
AL H +C L L+L++CCLT C ++ VLL S +L LDL N L++ GV + L
Sbjct: 769 ALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLL 828
Query: 825 HPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPH 884
P C + EL L GCF +SD C+ IA V+ N KL++L++G N+I D G++ LC L+HP+
Sbjct: 829 FPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPN 888
Query: 885 CKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCAL 944
C L +GL+ C +T ACC +A+ L KTL LNL L D V L E+L PDC L
Sbjct: 889 CMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVL 948
Query: 945 QMLGLHKSGFDEETQKILMSVEEKIPHLTISHGPWIDEEYKIRGV 989
+++GL +G + +TQ++LM+V+E+ P L W +E + GV
Sbjct: 949 KVVGLPLTGLNTQTQQLLMTVKERKPSLIFLSETWSLKEGREIGV 993
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 556 bits (1434), Expect = e-158
Identities = 345/1050 (32%), Positives = 546/1050 (52%), Gaps = 95/1050 (9%)
Query: 14 YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
YL+EL E KFK L E E K IPW ++KA ++A+LL H+ ++AW + L
Sbjct: 16 YLEELEAVELKKFKLYLGTATELGEGK-IPWGSMEKAGPLEMAQLLITHFGPEEAWRLAL 74
Query: 74 NLFLQINRKDLWTKAQEE-----------------------------MRNKLNPYRKHMK 104
+ F +INRKDLW + Q E ++ YR +++
Sbjct: 75 STFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVR 134
Query: 105 ETFQLIWEKET----CLHVPEHFYKETMKNEY-------KELNDAYTAAARR-------- 145
F+L+ ++ C+++ + + + E+ ++L D AR
Sbjct: 135 RKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPI 194
Query: 146 ----------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCE 189
TVV++G GIGK+ L KVMLDWA+G L++ RF ++F++N E
Sbjct: 195 KIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCRE 254
Query: 190 MNGIA-ETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQ-LKADLSDDW 247
MN A E S+ +L+ WPE S ++++ PER+LFI+DGF++LK + + W
Sbjct: 255 MNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCW 314
Query: 248 RQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYF 307
+++P ++L+SL++KK+LPE SLLI A++K + +L HP+ +++LGFSE+E+K YF
Sbjct: 315 EEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYF 374
Query: 308 SYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYL 367
+F +A +VFN+VRDN PLF +C P CW+VCTC++Q+LE G L S+ TT +
Sbjct: 375 YKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAV 434
Query: 368 YASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEG 425
Y +L ++ K G+ P N+ + LC+LAA+G+W +F DLR++GL +
Sbjct: 435 YMLYLLSLMQPKPGAPRLQPPPNQ---RGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
Query: 426 VMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVV 482
++ M + Q+ +C ++F+HL QEF AAM+Y+L + P +T+L+
Sbjct: 492 SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPD-QDVTRLLTEYAF 550
Query: 483 QPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAF 542
++ L F+FG+ EE S LE S + +S +K ++ Q ++S +Q +
Sbjct: 551 SERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGS 610
Query: 543 QELFIGLFETQEKEFVTKVMNFFEEVFI--YIGNIEHLVIASFCLKHCQHLTTLRMCVEN 600
E F L+E QE+EF+ + ++ F+ + + +EH+V +SFCLK C+ L +
Sbjct: 611 LEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMV-SSFCLKRCRSAQVLHLYGAT 669
Query: 601 IFPDDSG---CISDYNEKLV-----------YWRELCSMFITNKNFQILDMENTSLDDPS 646
D C + + LV Y L + TN N L + +L
Sbjct: 670 YSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRG 729
Query: 647 LAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFKAVLHNPHLKLLSLYGTSLSQSDIRH 704
+ +LC+ L P CKL+ L + +L A++ N +L + L G + +
Sbjct: 730 VKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMML 789
Query: 705 LCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCE 764
LCE L+HP C+++ + L KC + S C+++ASVL N L L L N L D G+ LLC+
Sbjct: 790 LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQ 849
Query: 765 ALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALK 824
L+H C L L L C LT+ +CD ++ L ++SL LDL N L D GV LC L+
Sbjct: 850 GLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLR 909
Query: 825 HPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPH 884
HP C ++ L L C L S +C+ ++ VL N L+ L L N++GD G+ L LQHP
Sbjct: 910 HPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPA 969
Query: 885 CKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCAL 944
C+L+ L L +C +T C+++ L +TL L L AL V +LC+ LSHP C L
Sbjct: 970 CRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKL 1029
Query: 945 QMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
++L L ++ T L ++ P+L I
Sbjct: 1030 RVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 524 bits (1350), Expect = e-148
Identities = 340/1055 (32%), Positives = 543/1055 (51%), Gaps = 123/1055 (11%)
Query: 14 YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
YL++L + KFK L+ + P+P + +KA D+A L+ ++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 NLFLQINRKDLWTKAQEE------------------------------------------ 91
+F INR+DL+ KA+ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 MRNKLNPYRKHMKETFQLIWEKETCLH--------------VPEHFYKETMKNEYKELND 137
++ YRK+++ FQ I ++ L + EH ++ + E +
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 138 AYTAAARR-------------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDR 178
T + HTVV +G GIGKT L RK+MLDWA G L++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 179 FTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLK--FN 236
F ++F+++ E++ + + SL +L+ P+ + I I +P RILF+MDGF++L+ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 237 LQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
+ L DW++ + I+LSSL++KK+LPE+SLLI +A++K +L HP+ +++L
Sbjct: 313 EHI-GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL 371
Query: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
GFSE+++K YF +F ++++A F+ +++N LF +C P CW+VCT +KQ++E G+
Sbjct: 372 GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKS 431
Query: 357 LEINSQNTTYLYASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGD 414
L S+ TT +Y FL+++ + GSQ A L LC+LAA+GIW +F D
Sbjct: 432 LAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC---AHLWGLCSLAADGIWNQKILFEESD 488
Query: 415 LRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIG 471
LR +GL +++ ++ M L Q+ DC ++F+H+ QEF AAM+YLL+ K+ G
Sbjct: 489 LRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPG 548
Query: 472 SITQLVRASVVQ--------PQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEI 523
S +L V + L V F+FG+ +E S LE +S+ ++ E+
Sbjct: 549 SRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLEL 608
Query: 524 TQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASF 583
+ +E ++ + + + ELF L+E QE++FV + M++F ++ I + +++SF
Sbjct: 609 LKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSF 668
Query: 584 CLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLD 643
C+++C + +L + + P + E+ K + LDM L
Sbjct: 669 CIENCHRVESLSLGFLHNMPKEE------EEE-------------EKEGRHLDMVQCVLP 709
Query: 644 DPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIR 703
S A L + + +S G LF + + L L L SL +R
Sbjct: 710 SSSHAACSHGL------VNSHLTSSFCRG----LFSVLSTSQSLTELDLSDNSLGDPGMR 759
Query: 704 HLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLC 763
LCETL+HP C I L LG+C +S E C DI+ VL+ N KL L L +N L D G+ LLC
Sbjct: 760 VLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 819
Query: 764 EALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAAL 823
LKH C L++L L+ CCLTS C ++ VL S SL+ L +G NAL D+GVA LC
Sbjct: 820 VGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKA 879
Query: 824 KHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHP 883
K+P C++++L L+ LTS C +++VL N L L L N +GD G++ LC L HP
Sbjct: 880 KNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP 939
Query: 884 HCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCA 943
CKL+ L L C +T CC D++ L + ++LR L+L L V++ CE L C
Sbjct: 940 DCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
Query: 944 LQMLGLHKSGFDEETQKILMSVEEKIPHLTISHGP 978
LQ LGL + F+ ET+ L +++E+ P LT+ P
Sbjct: 1000 LQNLGLSEMYFNYETKSALETLQEEKPELTVVFEP 1034
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 524 bits (1350), Expect = e-148
Identities = 340/1055 (32%), Positives = 543/1055 (51%), Gaps = 123/1055 (11%)
Query: 14 YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
YL++L + KFK L+ + P+P + +KA D+A L+ ++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 NLFLQINRKDLWTKAQEE------------------------------------------ 91
+F INR+DL+ KA+ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 MRNKLNPYRKHMKETFQLIWEKETCLH--------------VPEHFYKETMKNEYKELND 137
++ YRK+++ FQ I ++ L + EH ++ + E +
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 138 AYTAAARR-------------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDR 178
T + HTVV +G GIGKT L RK+MLDWA G L++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 179 FTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLK--FN 236
F ++F+++ E++ + + SL +L+ P+ + I I +P RILF+MDGF++L+ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 237 LQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
+ L DW++ + I+LSSL++KK+LPE+SLLI +A++K +L HP+ +++L
Sbjct: 313 EHI-GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL 371
Query: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
GFSE+++K YF +F ++++A F+ +++N LF +C P CW+VCT +KQ++E G+
Sbjct: 372 GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKS 431
Query: 357 LEINSQNTTYLYASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGD 414
L S+ TT +Y FL+++ + GSQ A L LC+LAA+GIW +F D
Sbjct: 432 LAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC---AHLWGLCSLAADGIWNQKILFEESD 488
Query: 415 LRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIG 471
LR +GL +++ ++ M L Q+ DC ++F+H+ QEF AAM+YLL+ K+ G
Sbjct: 489 LRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPG 548
Query: 472 SITQLVRASVVQ--------PQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEI 523
S +L V + L V F+FG+ +E S LE +S+ ++ E+
Sbjct: 549 SRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLEL 608
Query: 524 TQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASF 583
+ +E ++ + + + ELF L+E QE++FV + M++F ++ I + +++SF
Sbjct: 609 LKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSF 668
Query: 584 CLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLD 643
C+++C + +L + + P + E+ K + LDM L
Sbjct: 669 CIENCHRVESLSLGFLHNMPKEE------EEE-------------EKEGRHLDMVQCVLP 709
Query: 644 DPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIR 703
S A L + + +S G LF + + L L L SL +R
Sbjct: 710 SSSHAACSHGL------VNSHLTSSFCRG----LFSVLSTSQSLTELDLSDNSLGDPGMR 759
Query: 704 HLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLC 763
LCETL+HP C I L LG+C +S E C DI+ VL+ N KL L L +N L D G+ LLC
Sbjct: 760 VLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 819
Query: 764 EALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAAL 823
LKH C L++L L+ CCLTS C ++ VL S SL+ L +G NAL D+GVA LC
Sbjct: 820 VGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKA 879
Query: 824 KHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHP 883
K+P C++++L L+ LTS C +++VL N L L L N +GD G++ LC L HP
Sbjct: 880 KNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHP 939
Query: 884 HCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCA 943
CKL+ L L C +T CC D++ L + ++LR L+L L V++ CE L C
Sbjct: 940 DCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCL 999
Query: 944 LQMLGLHKSGFDEETQKILMSVEEKIPHLTISHGP 978
LQ LGL + F+ ET+ L +++E+ P LT+ P
Sbjct: 1000 LQNLGLSEMYFNYETKSALETLQEEKPELTVVFEP 1034
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 503 bits (1295), Expect = e-142
Identities = 337/1066 (31%), Positives = 545/1066 (51%), Gaps = 98/1066 (9%)
Query: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
M S F L L++L ++E KFK L+ EL+ IP E+ KA + + ++L
Sbjct: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
Query: 61 KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMR-------NKLNPY-----RKH------ 102
H +L +F +++R DL +A++E+R NK P RK
Sbjct: 61 THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV 120
Query: 103 --MKETFQLIWEKET------------------------CLHVPEHFYKETMKNEYKELN 136
M E F+ + T C ++ + ++E K+ +
Sbjct: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK 180
Query: 137 DAYTAAAR-----------------RHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRF 179
+ A R +TVVL GP G+GKTTL +K+MLDWAE NL +F
Sbjct: 181 EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KF 239
Query: 180 TFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNL-Q 238
+ F+L+ E++ + S EL+ RDWPE + I I +Q +ILF++DGF++L
Sbjct: 240 KYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGA 299
Query: 239 LKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGF 298
L D+ DW +++P+P++L SLL + MLP+++LL+ A++ + P I++ GF
Sbjct: 300 LIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGF 359
Query: 299 SESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLE 358
E ++++YF FG++ +A++ F +R N LF L P CW+VCT +K ++E+GED
Sbjct: 360 LEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPV 419
Query: 359 INSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRN 418
T L+ FL + F G+Q R L++L LAA+G+W T V DL R
Sbjct: 420 PTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLWAQTSVLHREDLERL 473
Query: 419 GLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKRPKDDPNPA----IG 471
G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++ +++ IG
Sbjct: 474 GVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIG 533
Query: 472 SITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLS 531
+ +L+ L Q G + FG++ E+ LE +FG +S D+KQE+ +C S
Sbjct: 534 DVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDIS-- 591
Query: 532 QCEADREAIA-FQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQH 590
C+ + QEL L+E+QE+E V +VM F+E+ +++ ++ +V +SFC+KHC++
Sbjct: 592 -CKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLHLNAVD-VVPSSFCVKHCRN 649
Query: 591 LTTLRMCV------ENIFPDDSGC----ISDYNEKLVYWRELCSMFITNKNFQILDMENT 640
L + + V EN+ +S D L +W +LCS+F +NK+ L + ++
Sbjct: 650 LQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLAINDS 709
Query: 641 SLDDPSLAILCKALAQPVCKLRKLIFTSVYFGH-DSELFKAVLHNPHLKLLSLYGTSLSQ 699
L + ILC+ +A C L++++F ++ L A+ + + L+L G Q
Sbjct: 710 FLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGND--Q 767
Query: 700 SDI-RHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEG 758
D+ LCE L+HP C + L L C +++ D++ L N L ++L +N L DEG
Sbjct: 768 DDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEG 827
Query: 759 MTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVAS 818
LL L+H C L+RL L C LT +C ++ VL+ S+ L+ L L N + + GV
Sbjct: 828 AKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKF 887
Query: 819 LCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCA 878
LC L++P C ++ L L C +TSD C D+ +L L L LG N IG G++ LC
Sbjct: 888 LCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCE 947
Query: 879 ALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALS 938
AL+ P C L CL L C I C+D+ +AL ++L +L+L L + V +L E L+
Sbjct: 948 ALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLT 1007
Query: 939 HPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI---SHGPWID 981
L+ L L F++E K+L +EEK P L I H PW +
Sbjct: 1008 CSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLIIDTEKHHPWAE 1053
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 499 bits (1286), Expect = e-141
Identities = 308/974 (31%), Positives = 507/974 (52%), Gaps = 52/974 (5%)
Query: 10 GLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAW 69
G++ Y++ + EE +FK+LL L + PI W +++ AS +V LL + +PG++AW
Sbjct: 40 GVMLYMRNVSHEELQRFKQLLLTELSTGTM-PITWDQVETASWAEVVHLLIERFPGRRAW 98
Query: 70 EVTLNLFLQINRKDLWTKAQEEMR-------------------------NKLNPYRKHMK 104
+VT N+F +N + + E+ K+ Y+ ++
Sbjct: 99 DVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVM 158
Query: 105 ETFQLIWEKETCLHVPEHFYKETMKNEYKELN----DAYTAAARRHTVVLEGPDGIGKTT 160
E F IW+ T F+ + + + L + TV ++G GIGKT
Sbjct: 159 EKFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTI 218
Query: 161 LLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQP 220
L +KVM +WA + + F+ + E+N + S EL+ + WP S + + I S+P
Sbjct: 219 LAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKP 278
Query: 221 ERILFIMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLA 279
+++L ++DGFE+L L DLS+DWRQ+ P ++LSSLL K MLPE++LLI + +
Sbjct: 279 DQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTS 338
Query: 280 MQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFT 339
Q +L+ P L+ L GF+ EK YF +FG + +V +F +N LF +C P
Sbjct: 339 WQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVV 398
Query: 340 CWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALA 399
CW+VC+ +KQ++ERG +L + N T ++ +++++F +++F K+++A+L+ LC LA
Sbjct: 399 CWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLA 458
Query: 400 AEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMF 456
A+ +W +V DL L ++ ++GM +L+R D + F + QEF AA+F
Sbjct: 459 ADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALF 518
Query: 457 YLLKRPKDDPNPAIGSITQLVR--ASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFP 514
Y+L P+ N + S + R AS ++ L+ +G+F+FG E S +E SF
Sbjct: 519 YVLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCK 578
Query: 515 LSKDLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGN 574
+S K+++ + + L +C+ +LF L E +E+ FV++ +N + +V + IGN
Sbjct: 579 VSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGN 638
Query: 575 IEHLVIASFCLKHCQHLTTLRMCVE----NIFPDDSGC-----ISDYNEKLVYWRELCSM 625
+ + +++FCLK CQ+L + + V N++ S + N +W++LCS+
Sbjct: 639 NKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSV 698
Query: 626 FITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGH-DSELFKAVLHN 684
F TN ++L M N+ L P L L AL P CKL+KL+ V + +L + N
Sbjct: 699 FATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGN 758
Query: 685 PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKL 744
HL+ L + + ++ LC L+ P C+++ L L C + + D+ + L N L
Sbjct: 759 QHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHL 818
Query: 745 KHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLL 804
K L L +N L + C A S LERL + C LT ++C+S++ L SK L+ L
Sbjct: 819 KTLILRKNSLEN------CGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHL 872
Query: 805 DLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLG 864
L NAL+D G + AL H C ++ L L C LT + C+D+ + L N LK+L L
Sbjct: 873 SLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLS 932
Query: 865 HNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIA 924
N + D GV LC AL++P C L+ L L+ C T CC +A+ L + LR L+L A
Sbjct: 933 FNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNA 992
Query: 925 LDADAVVVLCEALS 938
+ ++ LCEA S
Sbjct: 993 IGVYGILTLCEAFS 1006
Score = 145 bits (366), Expect = 2e-34
Identities = 92/289 (31%), Positives = 148/289 (51%), Gaps = 7/289 (2%)
Query: 684 NPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSK 743
N L++L++ + L ++ L L+HP CK+++L+L + + S+ + +D+ VL N
Sbjct: 702 NDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVN-STMLNQDLIGVLTGNQH 760
Query: 744 LKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSL 803
L++L + + + + LLC L+ C L+ L L C T + L + L
Sbjct: 761 LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLKT 820
Query: 804 LDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKL 863
L L N+LE+ G L A + L + C LT +C+ +A+ L + L L L
Sbjct: 821 LILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSL 874
Query: 864 GHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWI 923
N + D G + + AL H C L+ L L+ C +T CC D+ +AL KTL+SL+L +
Sbjct: 875 AENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFN 934
Query: 924 ALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHL 972
+L D V++LCEAL +PDC LQ+L L F + + S+ K HL
Sbjct: 935 SLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 494 bits (1271), Expect = e-139
Identities = 304/868 (35%), Positives = 466/868 (53%), Gaps = 22/868 (2%)
Query: 99 YRKHMKETFQLIWEKETCLHVPEHFY-KETMKNEYKELN---DAYTAAARRHTVVLEGPD 154
YR++MK W+ + +H Y + T K+E++EL D A+ T+VL G
Sbjct: 180 YRENMKAELLETWDNISW--PKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRA 237
Query: 155 GIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIE 214
G+GKTTL + ML WA G L++ RF++VF+L+ ++ + ET+ EL+S DWP+ IE
Sbjct: 238 GVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIE 297
Query: 215 DIFSQPERILFIMDGFEQLKFNLQLKADLSD-----DWRQRQPMPIILSSLLQKKMLPES 269
+ SQPE++LFI+DGFE++ + L D DW Q P+ IL SLL+K+++P +
Sbjct: 298 EFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLA 357
Query: 270 SLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGP 329
+LLI + ++ L +P +++ GF+ + + YF F + S+ K+ +R N
Sbjct: 358 TLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNET 417
Query: 330 LFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNR 389
LF C P CW VC+C+KQ R DL+ +Q TT LYA F + +F
Sbjct: 418 LFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWP 477
Query: 390 ARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHL 446
+ ++LC+LA EG+W+ F F+ D GL +LQ+ DC F HL
Sbjct: 478 GQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHL 537
Query: 447 CIQEFCAAMFYLLKRPKDDPNPAIG--SITQLVRASVVQPQTLLTQVGIFMFGISTEEIV 504
QEF AAM ++L+ P++ P + + L++ ++ + T V +F FG+ + I
Sbjct: 538 SFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIA 597
Query: 505 SMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNF 564
LE + +S + +E+ + E L + E+ LF L E+QE++F K++
Sbjct: 598 RELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGR 657
Query: 565 FEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVEN-IFPDDSGCI--SDYNEKLVYWRE 621
EV + I E L +SFCLKHC+ L LR+ V + I D + S ++ ++ W
Sbjct: 658 IFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKFDSRMHAWNS 717
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHD-SELFKA 680
+CS +TN+N LD+ N+ L S+ LC AL P CK++KL SV +L A
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
Query: 681 VLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLAC 740
+ N L L+ L + + + + L+H C ++ L L KC++S+ C+D+A L
Sbjct: 778 LQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
Query: 741 NSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKS 800
+ L L N L+D+G+ LLC AL H CALERL L +C L + +C +S+ LL ++S
Sbjct: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS 896
Query: 801 LSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKT 860
L+ L+L N+L D GV LC AL P +++ L L GC T + C ++A L N +K
Sbjct: 897 LTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKI 956
Query: 861 LKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNL 920
L LG N++ D GV+ LC AL+ PH L LGL C +T ACC + + L + K+L +LNL
Sbjct: 957 LDLGENDLQDDGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNL 1015
Query: 921 DWIALDADAVVVLCEALSHPDCALQMLG 948
LD D V +LC+AL C LQ LG
Sbjct: 1016 LGNELDTDGVKMLCKALKKSTCRLQKLG 1043
Score = 117 bits (294), Expect = 4e-26
Identities = 94/284 (33%), Positives = 129/284 (45%), Gaps = 12/284 (4%)
Query: 674 DSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCED 733
D EL + H K L+ S+S H+ E +E L K D
Sbjct: 668 DEELQASSFCLKHCKRLNKLRLSVSS----HILER------DLEILETSKFDSRMHAWNS 717
Query: 734 IASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISE 793
I S L N L L L + L + LC ALK+ C +++L V D I
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIA 777
Query: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
+ SK L+ L+ SN L V + AL+H C+++ L L C L++ SC+D+A L
Sbjct: 778 LQGNSK-LTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLT 835
Query: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
+ L LG N + D G++ LCAAL HP C LE L L C + C ++ AL+ +
Sbjct: 836 SIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNR 895
Query: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEE 957
+L LNL +L + V LCEAL PD LQ L L F E
Sbjct: 896 SLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
Score = 55.5 bits (132), Expect = 2e-07
Identities = 35/94 (37%), Positives = 51/94 (54%), Gaps = 7/94 (7%)
Query: 10 GLLWYLKELRKEEFWKFKELLK-QPLEKFELKP------IPWAELKKASKEDVAKLLDKH 62
GLL YL L + + +FK L+ Q L F P IPWA L+ A +++ LLD+H
Sbjct: 16 GLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEH 75
Query: 63 YPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKL 96
+P QAW+V L +F +N L K + EM+ +
Sbjct: 76 FPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENV 109
Score = 44.7 bits (104), Expect = 4e-04
Identities = 37/128 (28%), Positives = 57/128 (44%), Gaps = 6/128 (4%)
Query: 848 IAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA--CCDDI 905
I + L+ N L L L ++++ + V+ LC AL++P CK++ L TC D+
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKL---TCKSVTPEWVLQDL 774
Query: 906 AAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSV 965
AL L LN L ++L +AL H C L+ L L K + + L
Sbjct: 775 IIALQGNSKLTHLNFSSNKLGMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALF 833
Query: 966 EEKIPHLT 973
I H+T
Sbjct: 834 LTSIQHVT 841
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 462 bits (1188), Expect = e-130
Identities = 305/969 (31%), Positives = 492/969 (50%), Gaps = 123/969 (12%)
Query: 14 YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
YL++L + KFK L+ + P+P + +KA D+A L+ ++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 NLFLQINRKDLWTKAQEE------------------------------------------ 91
+F INR+DL+ KA+ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 MRNKLNPYRKHMKETFQLIWEKETCLH--------------VPEHFYKETMKNEYKELND 137
++ YRK+++ FQ I ++ L + EH ++ + E +
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 138 AYTAAARR-------------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDR 178
T + HTVV +G GIGKT L RK+MLDWA G L++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 179 FTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLK--FN 236
F ++F+++ E++ + + SL +L+ P+ + I I +P RILF+MDGF++L+ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 237 LQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
+ L DW++ + I+LSSL++KK+LPE+SLLI +A++K +L HP+ +++L
Sbjct: 313 EHI-GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL 371
Query: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
GFSE+++K YF +F ++++A F+ +++N LF +C P CW+VCT +KQ++E G+
Sbjct: 372 GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKS 431
Query: 357 LEINSQNTTYLYASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGD 414
L S+ TT +Y FL+++ + GSQ A L LC+LAA+GIW +F D
Sbjct: 432 LAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC---AHLWGLCSLAADGIWNQKILFEESD 488
Query: 415 LRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIG 471
LR +GL +++ ++ M L Q+ DC ++F+H+ QEF AAM+YLL+ K+ G
Sbjct: 489 LRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPG 548
Query: 472 SITQLVRASVVQ--------PQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEI 523
S +L V + L V F+FG+ +E S LE +S+ ++ E+
Sbjct: 549 SRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLEL 608
Query: 524 TQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASF 583
+ +E ++ + + + ELF L+E QE++FV + M++F ++ I + +++SF
Sbjct: 609 LKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSF 668
Query: 584 CLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLD 643
C+++C + +L + + P + E+ K + LDM L
Sbjct: 669 CIENCHRVESLSLGFLHNMPKEE------EEE-------------EKEGRHLDMVQCVLP 709
Query: 644 DPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIR 703
S A L + + +S G LF + + L L L SL +R
Sbjct: 710 SSSHAACSHGL------VNSHLTSSFCRG----LFSVLSTSQSLTELDLSDNSLGDPGMR 759
Query: 704 HLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLC 763
LCETL+HP C I L LG+C +S E C DI+ VL+ N KL L L +N L D G+ LLC
Sbjct: 760 VLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLC 819
Query: 764 EALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAAL 823
LKH C L++L L+ LTSV C ++S VL +++L+ L L N L D G+ LC L
Sbjct: 820 VGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGL 879
Query: 824 KHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHP 883
HP C ++ L L C LTS C D++ +L + L+ L LG+N++GD GV C L+
Sbjct: 880 LHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQ 939
Query: 884 HCKLECLGL 892
C L+ LGL
Sbjct: 940 SCLLQNLGL 948
Score = 184 bits (466), Expect = 5e-46
Identities = 101/253 (39%), Positives = 143/253 (56%)
Query: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
++S C + SVL+ + L L L +N L D GM +LCE L+H C + RL L C L+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSC 845
C IS VL ++ L LDL NAL D G+ LC LKH C++++LWL+ LTS C
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 844
Query: 846 KDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDI 905
+++VL N L L L N +GD G++ LC L HP CKL+ L L C +T CC D+
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
Query: 906 AAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSV 965
+ L + ++LR L+L L V++ CE L C LQ LGL + F+ ET+ L ++
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETL 964
Query: 966 EEKIPHLTISHGP 978
+E+ P LT+ P
Sbjct: 965 QEEKPELTVVFEP 977
Score = 80.5 bits (197), Expect = 7e-15
Identities = 53/149 (35%), Positives = 71/149 (47%), Gaps = 3/149 (2%)
Query: 825 HPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPH 884
H CS L+ LTS C+ + +VL + L L L N +GD G+R LC LQHP
Sbjct: 713 HAACSHG---LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPG 769
Query: 885 CKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCAL 944
C + L L C ++ CC DI+ L + + L L+L AL + +LC L H C L
Sbjct: 770 CNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNL 829
Query: 945 QMLGLHKSGFDEETQKILMSVEEKIPHLT 973
+ L L SG L SV +LT
Sbjct: 830 KKLWLVNSGLTSVCCSALSSVLSTNQNLT 858
Score = 44.7 bits (104), Expect = 4e-04
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 2/104 (1%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFK 679
L S+ TN+N L + +L D + +LC+ L P CKL+ L + +L
Sbjct: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGK 723
+ + L+ LSL L + CE LK C ++ L L +
Sbjct: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
Score = 33.1 bits (74), Expect = 1.3
Identities = 13/56 (23%), Positives = 32/56 (57%)
Query: 621 ELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSE 676
+L ++ ++++ + L + N L D + + C+ L Q C L+ L + +YF ++++
Sbjct: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 452 bits (1162), Expect = e-127
Identities = 315/1021 (30%), Positives = 518/1021 (50%), Gaps = 75/1021 (7%)
Query: 15 LKELRKEEFWKFKELLKQ-PLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
L++L ++E FK LL PLE L+ PW+E+++A + +A++L T+
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDV-LQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
Query: 74 NLFLQINRKDLWTKAQEEMRNKL------NP-------------------YRKHMKETFQ 108
N+ ++N +L A+ EM NP +R M++
Sbjct: 73 NILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQ-S 131
Query: 109 LIWEKETCLHVPEHFYKE-TMKNE--YKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKV 165
L+W+ ++F+ + T++N+ LN +TVVL GP G+GKTTL +K
Sbjct: 132 LVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
Query: 166 MLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILF 225
MLDW + NL + F+L+ E++ + S EL+S+DWPE + I I +Q +RILF
Sbjct: 192 MLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
Query: 226 IMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHY 284
++DG ++LK L D+ DW +++P+P++L SLL++KMLP ++LL+ A++
Sbjct: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
Query: 285 FMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVC 344
+ + P +++ GF E ++++YF FG++ +A++ F +R N LF L P CW+VC
Sbjct: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
Query: 345 TCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIW 404
T +K ++E+GED T L+ FL + F G+Q R L++L LAA+G+W
Sbjct: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLW 424
Query: 405 TYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKR 461
VF DL R G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 462 PKDDPNPA----IGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSK 517
+ + IG + +L+ L QVG F+FG++ E+ LE +FG +S
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
Query: 518 DLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEH 577
D+KQE+ QC L +E+ L+E+QE+E V+ F+E+ I++ N
Sbjct: 545 DIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
Query: 578 LVIASFCLKHCQHLTTLRMCV-ENIFPDDSGCISDYN-----EKLVY------------- 618
++ SF LKHCQ L L + V + +F ++ D+ E+ Y
Sbjct: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLEN---YMDFELDIEFERCTYLTIPNWARQDLRS 660
Query: 619 ---WRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS 675
W + CS+F +N N + L+++ + L D S+ ILC + + C L+K+ +V
Sbjct: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
Query: 676 ELF-KAVLHNPHLKLLSLYG-TSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCED 733
F A + L L+L G ++ + LC+ L++ C ++ L LG + E +
Sbjct: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
Query: 734 IASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISE 793
VL N LKHL L N L DEG LL + + L+ L L C LT SC ++
Sbjct: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
Query: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
VL+ SK L+ L L N + D GV LC L +P C ++ L L C +T C+ ++ L
Sbjct: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
Query: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
L L L N+I G+ LC AL++P+C L+ L L +C + C + +AL++ +
Sbjct: 901 EACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQ 959
Query: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLT 973
L +L+L L ++ L L +L++L L + E +K+L V+EK P LT
Sbjct: 960 KLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLT 1019
Query: 974 I 974
I
Sbjct: 1020 I 1020
Score = 97.8 bits (242), Expect = 4e-20
Identities = 76/257 (29%), Positives = 117/257 (45%), Gaps = 10/257 (3%)
Query: 733 DIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSIS 792
D S+ + NS LK L + ++ L D + +LC+ + S C L+++ + + D
Sbjct: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD-FC 724
Query: 793 EVLLCSKSLSLLDL-GSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAV 851
+ K+L+ L L G E + LC L++ C+++ L L G T + + V
Sbjct: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
Query: 852 LICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIA 911
L N LK L+L N + D G L + P L+ L L+ C +T A C D+AA L+
Sbjct: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
Query: 912 CKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPH 971
K L L L + V LCE LS+PDC LQ L L + + + L ++
Sbjct: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 904
Query: 972 LT--------ISHGPWI 980
LT I+ G WI
Sbjct: 905 LTNLDLSINQIARGLWI 921
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 447 bits (1151), Expect = e-125
Identities = 297/971 (30%), Positives = 491/971 (50%), Gaps = 127/971 (13%)
Query: 14 YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
YL++L + KFK L+ + P+P + +KA D+A L+ ++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 NLFLQINRKDLWTKAQEE------------------------------------------ 91
+F INR+DL+ KA+ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 MRNKLNPYRKHMKETFQLIWEKETCLH--------------VPEHFYKETMKNEYKELND 137
++ YRK+++ FQ I ++ L + EH ++ + E +
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 138 AYTAAARR-------------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDR 178
T + HTVV +G GIGKT L RK+MLDWA G L++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 179 FTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLK--FN 236
F ++F+++ E++ + + SL +L+ P+ + I I +P RILF+MDGF++L+ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 237 LQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
+ L DW++ + I+LSSL++KK+LPE+SLLI +A++K +L HP+ +++L
Sbjct: 313 EHI-GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL 371
Query: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
GFSE+++K YF +F ++++A F+ +++N LF +C P CW+VCT +KQ++E G+
Sbjct: 372 GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKS 431
Query: 357 LEINSQNTTYLYASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGD 414
L S+ TT +Y FL+++ + GSQ A L LC+LAA+GIW +F D
Sbjct: 432 LAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC---AHLWGLCSLAADGIWNQKILFEESD 488
Query: 415 LRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIG 471
LR +GL +++ ++ M L Q+ DC ++F+H+ QEF AAM+YLL+ K+ G
Sbjct: 489 LRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPG 548
Query: 472 SITQLVRASVVQ--------PQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEI 523
S +L V + L V F+FG+ +E S LE +S+ ++ E+
Sbjct: 549 SRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLEL 608
Query: 524 TQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASF 583
+ +E ++ + + + ELF L+E QE++FV + M++F ++ I + +++SF
Sbjct: 609 LKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSF 668
Query: 584 CLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLD 643
C+++C + +L + + P + E+ K + LDM L
Sbjct: 669 CIENCHRVESLSLGFLHNMPKEE------EEE-------------EKEGRHLDMVQCVLP 709
Query: 644 DPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFKAVLHNPHLKLLSLYGTSLSQSD 701
S A L + C L H+ ++ + N L L L +L
Sbjct: 710 SSSHAACSHGLGR--CGL----------SHECCFDISLVLSSNQKLVELDLSDNALGDFG 757
Query: 702 IRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTL 761
IR LC LKH +C +++L L C ++S C+D+ASVL+ + L L + EN L D G+ +
Sbjct: 758 IRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAI 817
Query: 762 LCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCA 821
LCE K+ C L++L L+ LTSV C ++S VL +++L+ L L N L D G+ LC
Sbjct: 818 LCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 877
Query: 822 ALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQ 881
L HP C ++ L L C LTS C D++ +L + L+ L LG+N++GD GV C L+
Sbjct: 878 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 937
Query: 882 HPHCKLECLGL 892
C L+ LGL
Sbjct: 938 QQSCLLQNLGL 948
Score = 204 bits (518), Expect = 4e-52
Identities = 110/258 (42%), Positives = 154/258 (59%)
Query: 721 LGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMY 780
LG+C +S E C DI+ VL+ N KL L L +N L D G+ LLC LKH C L++L L+
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
CCLTS C ++ VL S SL+ L +G NAL D+GVA LC K+P C++++L L+ L
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
TS C +++VL N L L L N +GD G++ LC L HP CKL+ L L C +T
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
CC D++ L + ++LR L+L L V++ CE L C LQ LGL + F+ ET+
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 961 ILMSVEEKIPHLTISHGP 978
L +++E+ P LT+ P
Sbjct: 960 ALETLQEEKPELTVVFEP 977
Score = 44.7 bits (104), Expect = 4e-04
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 2/104 (1%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFK 679
L S+ TN+N L + +L D + +LC+ L P CKL+ L + +L
Sbjct: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGK 723
+ + L+ LSL L + CE LK C ++ L L +
Sbjct: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
Score = 35.4 bits (80), Expect = 0.27
Identities = 21/59 (35%), Positives = 30/59 (50%)
Query: 891 GLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
GL C ++ CC DI+ L + + L L+L AL + +LC L H C L+ L L
Sbjct: 719 GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 777
Score = 33.1 bits (74), Expect = 1.3
Identities = 13/56 (23%), Positives = 32/56 (57%)
Query: 621 ELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSE 676
+L ++ ++++ + L + N L D + + C+ L Q C L+ L + +YF ++++
Sbjct: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 958
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 443 bits (1139), Expect = e-124
Identities = 283/861 (32%), Positives = 440/861 (51%), Gaps = 44/861 (5%)
Query: 144 RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLS 203
R TVVL G GIGK+ L R+++L WA+G L++ F++VFFL V EM E+S+ E +S
Sbjct: 278 RPRTVVLHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFIS 337
Query: 204 RDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQLKADLSDDWRQRQPMPIILSSLLQK 263
R+WP+S + +I S+PER+LFI+DGF+ L L L DW ++QP ++ SLL+K
Sbjct: 338 REWPDSQAPVTEIMSRPERLLFIIDGFDDLGSVLNNDTKLCKDWAEKQPPFTLIRSLLRK 397
Query: 264 KMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFS-ESEKKSYFSYFFGEKSKALKVFN 322
+LPES L++ + + +K + P+ + + G S E GE K +
Sbjct: 398 VLLPESFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKT-QGLR 456
Query: 323 FVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQS 382
+ +N L C P L+C ++ + GE + +Q T L+A+F+ Q
Sbjct: 457 AIMNNRELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVF------HQL 510
Query: 383 FPPKV--------NRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLL 434
P V R LK C +A EG+W VF DL GL ESE M +L
Sbjct: 511 TPRGVVRRCLNLEERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNIL 570
Query: 435 QRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQV 491
C + F HL +Q+FCAA++Y+L+ + +P + + R+ L Q
Sbjct: 571 LPDSHCEEYYTFFHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSME------LKQA 624
Query: 492 GI---------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAF 542
G F+FG+ +E++ LE G P+ +KQ++ + L Q
Sbjct: 625 GFHIHSLWMKRFLFGLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDT 684
Query: 543 QELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIF 602
+ F LFETQ+KEFV +N F+EV++ I L+ +SFCL+HC +L +R+ V+ IF
Sbjct: 685 LDAFHCLFETQDKEFVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIF 744
Query: 603 PDDSGC---------ISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKA 653
P D + D W + CSM T+ + + LD+ ++ L + ++ LC
Sbjct: 745 PRDESAEACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAK 804
Query: 654 LAQPVCKLRKLIFTSVYFGHD-SELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHP 712
L P CK++ L+F + L++ V+ N +L+ L+L GT L + D+R CE LKHP
Sbjct: 805 LRHPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHP 864
Query: 713 MCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCA 772
C +E L L C ++ I+ +L + LK LSL N + D+G+ L +AL+ S CA
Sbjct: 865 KCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCA 924
Query: 773 LERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRE 832
L++L+L C +T+ C S++ L+ ++SL+ L L +N+L + GV LC +++ P CS++
Sbjct: 925 LQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQR 984
Query: 833 LWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
L L C L + C +A L+ N L L L N + D GV+ LC ++ P C L+ L L
Sbjct: 985 LMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
Query: 893 QTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKS 952
C +T ACC+ ++ + + L+SL+L AL V LCE L + L LGL
Sbjct: 1045 VKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKAC 1104
Query: 953 GFDEETQKILMSVEEKIPHLT 973
G + + L HLT
Sbjct: 1105 GLTSDCCEALSLALSCNRHLT 1125
Score = 210 bits (535), Expect = 5e-54
Identities = 119/362 (32%), Positives = 194/362 (53%), Gaps = 3/362 (0%)
Query: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--EL 677
+ L + + N+N + L++ T L + + + C+AL P C L L H ++
Sbjct: 827 QHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKI 886
Query: 678 FKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
+ + +P LK LSL G ++ + L + L+ C +++LIL C I++ C+ +AS
Sbjct: 887 SQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASA 946
Query: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
L N L HL L N L +EG+ LLC +++ HC+L+RLML C L + C ++ L+
Sbjct: 947 LVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMG 1006
Query: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
+ L+ L L N +EDNGV LC ++ P C +++L L+ C LT+ C+ ++ V+ +
Sbjct: 1007 NSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRH 1066
Query: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
LK+L L N +GD GV LC L+ + L LGL+ C +T CC+ ++ AL + L S
Sbjct: 1067 LKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTS 1126
Query: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTISHG 977
LNL ++ LC A + P LQ++GL K + + +K+L V+ P + I G
Sbjct: 1127 LNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVID-G 1185
Query: 978 PW 979
W
Sbjct: 1186 SW 1187
Score = 67.4 bits (163), Expect = 6e-11
Identities = 35/88 (39%), Positives = 54/88 (61%)
Query: 6 FSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPG 65
FS +GL W L EL KEEF FKELLK+ + IP E++ A+ E +A LL ++Y
Sbjct: 60 FSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGA 119
Query: 66 KQAWEVTLNLFLQINRKDLWTKAQEEMR 93
AW ++++F +N + L KA+++M+
Sbjct: 120 SLAWATSISIFENMNLRTLSEKARDDMK 147
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 442 bits (1138), Expect = e-124
Identities = 309/1000 (30%), Positives = 511/1000 (51%), Gaps = 61/1000 (6%)
Query: 15 LKELRKEEFWKFKELLKQ-PLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
L++L ++E FK LL PLE L+ PW+E+++A + +A++L T+
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDV-LQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
Query: 74 NLFLQINRKDLWTKAQEEMRNKL------NP-------------------YRKHMKETFQ 108
N+ ++N +L A+ EM NP +R M++
Sbjct: 73 NILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQ-S 131
Query: 109 LIWEKETCLHVPEHFYKE-TMKNE--YKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKV 165
L+W+ ++F+ + T++N+ LN +TVVL GP G+GKTTL +K
Sbjct: 132 LVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
Query: 166 MLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILF 225
MLDW + NL + F+L+ E++ + S EL+S+DWPE + I I +Q +RILF
Sbjct: 192 MLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
Query: 226 IMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHY 284
++DG ++LK L D+ DW +++P+P++L SLL++KMLP ++LL+ A++
Sbjct: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
Query: 285 FMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVC 344
+ + P +++ GF E ++++YF FG++ +A++ F +R N LF L P CW+VC
Sbjct: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
Query: 345 TCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIW 404
T +K ++E+GED T L+ FL + F G+Q R L++L LAA+G+W
Sbjct: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLW 424
Query: 405 TYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKR 461
VF DL R G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 462 PKDDPNPA----IGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSK 517
+ + IG + +L+ L QVG F+FG++ E+ LE +FG +S
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
Query: 518 DLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEH 577
D+KQE+ QC L +E+ L+E+QE+E V+ F+E+ I++ N
Sbjct: 545 DIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
Query: 578 LVIASFCLKHCQHLTTLRMCV-ENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILD 636
++ SF LKHCQ L L + V + +F ++ D+ + + +N N + L+
Sbjct: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLEN---YMDFELDIEFES-------SNSNLKFLE 653
Query: 637 MENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELF-KAVLHNPHLKLLSLYG- 694
++ + L D S+ ILC + + C L+K+ +V F A + L L+L G
Sbjct: 654 VKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGH 713
Query: 695 TSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPL 754
++ + LC+ L++ C ++ L LG + E + VL N LKHL L N L
Sbjct: 714 IEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVL 773
Query: 755 RDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDN 814
DEG LL + + L+ L L C LT SC ++ VL+ SK L+ L L N + D
Sbjct: 774 LDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDT 833
Query: 815 GVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVR 874
GV LC L +P C ++ L L C +T C+ ++ L L L L N+I G+
Sbjct: 834 GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLW 892
Query: 875 QLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLC 934
LC AL++P+C L+ L L +C + C + +AL++ + L +L+L L ++ L
Sbjct: 893 ILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLF 952
Query: 935 EALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
L +L++L L + E +K+L V+EK P LTI
Sbjct: 953 GVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 433 bits (1113), Expect = e-121
Identities = 313/999 (31%), Positives = 505/999 (50%), Gaps = 88/999 (8%)
Query: 15 LKELRKEEFWKFKELLKQ-PLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
L++L ++E FK LL PLE L+ PW+E+++A + +A++L T+
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDV-LQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
Query: 74 NLFLQINRKDLWTKAQEEMRNKL------NP-------------------YRKHMKETFQ 108
N+ ++N +L A+ EM NP +R M++
Sbjct: 73 NILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQ-S 131
Query: 109 LIWEKETCLHVPEHFYKE-TMKNE--YKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKV 165
L+W+ ++F+ + T++N+ LN +TVVL GP G+GKTTL +K
Sbjct: 132 LVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
Query: 166 MLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILF 225
MLDW + NL + F+L+ E++ + S EL+S+DWPE + I I +Q +RILF
Sbjct: 192 MLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
Query: 226 IMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHY 284
++DG ++LK L D+ DW +++P+P++L SLL++KMLP ++LL+ A++
Sbjct: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
Query: 285 FMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVC 344
+ + P +++ GF E ++++YF FG++ +A++ F +R N LF L P CW+VC
Sbjct: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
Query: 345 TCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIW 404
T +K ++E+GED T L+ FL + F G+Q R L++L LAA+G+W
Sbjct: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLW 424
Query: 405 TYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKR 461
VF DL R G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++
Sbjct: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
Query: 462 PKDDPNPA----IGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSK 517
+ + IG + +L+ L QVG F+FG++ E+ LE +FG +S
Sbjct: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
Query: 518 DLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEH 577
D+KQE+ QC L +E+ L+E+QE+E V+ F+E+ I++ N
Sbjct: 545 DIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
Query: 578 LVIASFCLKHCQHLTTLRMCV-ENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILD 636
++ SF LKHCQ L L + V + +F ++ D+ + + E C+ ++T N+ D
Sbjct: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLEN---YMDFELDIEF--ERCT-YLTIPNWARQD 657
Query: 637 MENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTS 696
+ + L C L F+S N +LK L + +
Sbjct: 658 LRSLRL------------WTDFCSL----FSS---------------NSNLKFLEVKQSF 686
Query: 697 LSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRD 756
LS S +R LC+ + C ++++ + K D L HL+L + +
Sbjct: 687 LSDSSVRILCDHVTRSTCHLQKVEI-KNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWE 745
Query: 757 EGMTL-LCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNG 815
M L LC+ L++ C L+ L L C T VL ++SL L L +N L D G
Sbjct: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
Query: 816 VASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQ 875
L + P ++ L L C LT SCKD+AAVL+ + KL L L N IGDTGV+
Sbjct: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
Query: 876 LCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCE 935
LC L +P CKL+ L LQ C IT+ C ++ AL +L +L+L I A + +LC+
Sbjct: 866 LCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS-INQIARGLWILCQ 924
Query: 936 ALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
AL +P+C L+ L L + E +K+L V+EK P LTI
Sbjct: 925 ALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 397 bits (1021), Expect = e-110
Identities = 276/914 (30%), Positives = 452/914 (49%), Gaps = 127/914 (13%)
Query: 14 YLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
YL++L + KFK L+ + P+P + +KA D+A L+ ++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 NLFLQINRKDLWTKAQEE------------------------------------------ 91
+F INR+DL+ KA+ +
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 MRNKLNPYRKHMKETFQLIWEKETCLH--------------VPEHFYKETMKNEYKELND 137
++ YRK+++ FQ I ++ L + EH ++ + E +
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 138 AYTAAARR-------------------HTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDR 178
T + HTVV +G GIGKT L RK+MLDWA G L++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 179 FTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLK--FN 236
F ++F+++ E++ + + SL +L+ P+ + I I +P RILF+MDGF++L+ F+
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 237 LQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
+ L DW++ + I+LSSL++KK+LPE+SLLI +A++K +L HP+ +++L
Sbjct: 313 EHI-GPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL 371
Query: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
GFSE+++K YF +F ++++A F+ +++N LF +C P CW+VCT +KQ++E G+
Sbjct: 372 GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKS 431
Query: 357 LEINSQNTTYLYASFLTTVF--KAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGD 414
L S+ TT +Y FL+++ + GSQ A L LC+LAA+GIW +F D
Sbjct: 432 LAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLC---AHLWGLCSLAADGIWNQKILFEESD 488
Query: 415 LRRNGLSESEGVMWVGMRLLQRRGDC---FAFMHLCIQEFCAAMFYLLKRPKDDPNPAIG 471
LR +GL +++ ++ M L Q+ DC ++F+H+ QEF AAM+YLL+ K+ G
Sbjct: 489 LRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPG 548
Query: 472 SITQLVRASVVQ--------PQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEI 523
S +L V + L V F+FG+ +E S LE +S+ ++ E+
Sbjct: 549 SRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLEL 608
Query: 524 TQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASF 583
+ +E ++ + + + ELF L+E QE++FV + M++F ++ I + +++SF
Sbjct: 609 LKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSF 668
Query: 584 CLKHCQHLTTLRMCVENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLD 643
C+++C + +L + + P + E+ K + LDM L
Sbjct: 669 CIENCHRVESLSLGFLHNMPKEE------EEE-------------EKEGRHLDMVQCVLP 709
Query: 644 DPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFKAVLHNPHLKLLSLYGTSLSQSD 701
S A L + C L H+ ++ + N L L L +L
Sbjct: 710 SSSHAACSHGLGR--CGL----------SHECCFDISLVLSSNQKLVELDLSDNALGDFG 757
Query: 702 IRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTL 761
IR LC LKH +C +++L L ++S C ++SVL+ N L HL L N L D+G+ L
Sbjct: 758 IRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKL 817
Query: 762 LCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCA 821
LCE L H C L+ L L C LTS C +S +L S+SL L LG+N L D GV C
Sbjct: 818 LCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCE 877
Query: 822 ALKHPGCSIRELWL 835
LK C ++ L L
Sbjct: 878 VLKQQSCLLQNLGL 891
Score = 144 bits (362), Expect = 5e-34
Identities = 84/216 (38%), Positives = 117/216 (54%), Gaps = 1/216 (0%)
Query: 763 CEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAA 822
C SH A L C L+ C IS VL ++ L LDL NAL D G+ LC
Sbjct: 706 CVLPSSSHAACSH-GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVG 764
Query: 823 LKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQH 882
LKH C++++LWL+ LTS C +++VL N L L L N +GD G++ LC L H
Sbjct: 765 LKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLH 824
Query: 883 PHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDC 942
P CKL+ L L C +T CC D++ L + ++LR L+L L V++ CE L C
Sbjct: 825 PDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSC 884
Query: 943 ALQMLGLHKSGFDEETQKILMSVEEKIPHLTISHGP 978
LQ LGL + F+ ET+ L +++E+ P LT+ P
Sbjct: 885 LLQNLGLSEMYFNYETKSALETLQEEKPELTVVFEP 920
Score = 141 bits (356), Expect = 3e-33
Identities = 75/172 (43%), Positives = 103/172 (59%)
Query: 721 LGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMY 780
LG+C +S E C DI+ VL+ N KL L L +N L D G+ LLC LKH C L++L L+
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
LTSV C ++S VL +++L+ L L N L D G+ LC L HP C ++ L L C L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
TS C D++ +L + L+ L LG+N++GD GV C L+ C L+ LGL
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
Score = 44.7 bits (104), Expect = 4e-04
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 2/104 (1%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDS--ELFK 679
L S+ TN+N L + +L D + +LC+ L P CKL+ L + +L
Sbjct: 790 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 849
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGK 723
+ + L+ LSL L + CE LK C ++ L L +
Sbjct: 850 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893
Score = 33.1 bits (74), Expect = 1.3
Identities = 13/56 (23%), Positives = 32/56 (57%)
Query: 621 ELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSE 676
+L ++ ++++ + L + N L D + + C+ L Q C L+ L + +YF ++++
Sbjct: 846 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETK 901
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 339 bits (869), Expect = 9e-93
Identities = 257/846 (30%), Positives = 395/846 (46%), Gaps = 107/846 (12%)
Query: 26 FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85
+ E+ ++ EK E PWA + + L H+P WE ++ L W
Sbjct: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
Query: 86 TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141
E+ K R H + L+ P+ Y E + E+ D +
Sbjct: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
Query: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198
V+L+G GIGK+TL R+V W G L+ DRF VF+ + E+ SL
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
Query: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257
EL+ +D + I I S+PER+LFI+DG ++ + LQ ++L W Q QP +L
Sbjct: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
Query: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317
SLL K +LPE+S LI A+Q L + +++LGFSES +K YF +F ++ +A
Sbjct: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
Query: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377
++ F V+ N L+ LC P+ WL CTC+ Q+++R E L + S+ TT L +L +
Sbjct: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
Query: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437
A Q P+ L+ LC+LAAEGIW +FS DLR++GL + ++ M +LQ
Sbjct: 561 A--QPLGPQ-----LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
Query: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493
++F+HLC QEF AAM Y+L+ K + ++ + L GI
Sbjct: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
Query: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545
F+ G+ ++E +E F LS+ + + Q + SL E
Sbjct: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
Query: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605
L+ET+ K F+T+VM FEE+ + + L++ +FC+K +H+ L++
Sbjct: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
Query: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665
I ++ S P++ +L R +
Sbjct: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
Query: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
T Y+ LF + +LK L L G SLS S ++ LC+TL+ P C +E L L C
Sbjct: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
Query: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
+++E C+D+A L N L L L N L D G LC+ L+ C L+RL L+ C LTS
Sbjct: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
Query: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSC 845
C ++ VL S SL LDL N L+D GV LC L+HP C + L L L+ +
Sbjct: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMR 968
Query: 846 KDIAAV 851
+++ A+
Sbjct: 969 QELRAL 974
Score = 136 bits (342), Expect = 1e-31
Identities = 73/181 (40%), Positives = 104/181 (57%)
Query: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
VL +++L LDL N+L + V SLC L+ P C + L L GC LT++ CKD+A L
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
Query: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
N L L L N + D G + LC L+ P CKL+ L L +C +T CC D+A+ L A
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
Query: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLT 973
+L+ L+L LD V +LCE L HP C L LGL ++ +E ++ L ++E++ P L
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
Query: 974 I 974
I
Sbjct: 983 I 983
Score = 124 bits (310), Expect = 6e-28
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
SVL LK L L N L + LC+ L+ C LE L L C LT+ C ++ L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
+++L+ LDL N L D G LC L+ P C ++ L L+ C LTSD C+D+A+VL +
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
LK L L N + D GVR LC L+HP CKL LGL
Sbjct: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/123 (35%), Positives = 57/123 (46%)
Query: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
+VL LK L L N + + V+ LC L+ P C LE L L C +T C D+A L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969
A +TL L+L + L LC+ L P C LQ L L G + + L SV
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 970 PHL 972
P L
Sbjct: 922 PSL 924
Score = 38.9 bits (89), Expect = 0.024
Identities = 25/80 (31%), Positives = 41/80 (51%)
Query: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
L YL+ L+KEE +F+ LL A+ +K S +VA L Y ++AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 VTLNLFLQINRKDLWTKAQE 90
+ L+ + Q+ + L +AQE
Sbjct: 69 LALHTWEQMGLRSLCAQAQE 88
Score = 34.3 bits (77), Expect = 0.59
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955
P+T A + + L + L+ L+L +L AV LC+ L P C L+ L L G
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 956 EETQKIL 962
E K L
Sbjct: 851 AEDCKDL 857
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 339 bits (869), Expect = 9e-93
Identities = 257/846 (30%), Positives = 395/846 (46%), Gaps = 107/846 (12%)
Query: 26 FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85
+ E+ ++ EK E PWA + + L H+P WE ++ L W
Sbjct: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
Query: 86 TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141
E+ K R H + L+ P+ Y E + E+ D +
Sbjct: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
Query: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198
V+L+G GIGK+TL R+V W G L+ DRF VF+ + E+ SL
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
Query: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257
EL+ +D + I I S+PER+LFI+DG ++ + LQ ++L W Q QP +L
Sbjct: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
Query: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317
SLL K +LPE+S LI A+Q L + +++LGFSES +K YF +F ++ +A
Sbjct: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
Query: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377
++ F V+ N L+ LC P+ WL CTC+ Q+++R E L + S+ TT L +L +
Sbjct: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
Query: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437
A Q P+ L+ LC+LAAEGIW +FS DLR++GL + ++ M +LQ
Sbjct: 561 A--QPLGPQ-----LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
Query: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493
++F+HLC QEF AAM Y+L+ K + ++ + L GI
Sbjct: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
Query: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545
F+ G+ ++E +E F LS+ + + Q + SL E
Sbjct: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
Query: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605
L+ET+ K F+T+VM FEE+ + + L++ +FC+K +H+ L++
Sbjct: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
Query: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665
I ++ S P++ +L R +
Sbjct: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
Query: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
T Y+ LF + +LK L L G SLS S ++ LC+TL+ P C +E L L C
Sbjct: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
Query: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
+++E C+D+A L N L L L N L D G LC+ L+ C L+RL L+ C LTS
Sbjct: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
Query: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSC 845
C ++ VL S SL LDL N L+D GV LC L+HP C + L L L+ +
Sbjct: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMR 968
Query: 846 KDIAAV 851
+++ A+
Sbjct: 969 QELRAL 974
Score = 136 bits (342), Expect = 1e-31
Identities = 73/181 (40%), Positives = 104/181 (57%)
Query: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
VL +++L LDL N+L + V SLC L+ P C + L L GC LT++ CKD+A L
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
Query: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
N L L L N + D G + LC L+ P CKL+ L L +C +T CC D+A+ L A
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
Query: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLT 973
+L+ L+L LD V +LCE L HP C L LGL ++ +E ++ L ++E++ P L
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
Query: 974 I 974
I
Sbjct: 983 I 983
Score = 124 bits (310), Expect = 6e-28
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
SVL LK L L N L + LC+ L+ C LE L L C LT+ C ++ L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
+++L+ LDL N L D G LC L+ P C ++ L L+ C LTSD C+D+A+VL +
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
LK L L N + D GVR LC L+HP CKL LGL
Sbjct: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/123 (35%), Positives = 57/123 (46%)
Query: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
+VL LK L L N + + V+ LC L+ P C LE L L C +T C D+A L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969
A +TL L+L + L LC+ L P C LQ L L G + + L SV
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 970 PHL 972
P L
Sbjct: 922 PSL 924
Score = 38.9 bits (89), Expect = 0.024
Identities = 25/80 (31%), Positives = 41/80 (51%)
Query: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
L YL+ L+KEE +F+ LL A+ +K S +VA L Y ++AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 VTLNLFLQINRKDLWTKAQE 90
+ L+ + Q+ + L +AQE
Sbjct: 69 LALHTWEQMGLRSLCAQAQE 88
Score = 34.3 bits (77), Expect = 0.59
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955
P+T A + + L + L+ L+L +L AV LC+ L P C L+ L L G
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 956 EETQKIL 962
E K L
Sbjct: 851 AEDCKDL 857
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 339 bits (869), Expect = 9e-93
Identities = 257/846 (30%), Positives = 395/846 (46%), Gaps = 107/846 (12%)
Query: 26 FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85
+ E+ ++ EK E PWA + + L H+P WE ++ L W
Sbjct: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
Query: 86 TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141
E+ K R H + L+ P+ Y E + E+ D +
Sbjct: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
Query: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198
V+L+G GIGK+TL R+V W G L+ DRF VF+ + E+ SL
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
Query: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257
EL+ +D + I I S+PER+LFI+DG ++ + LQ ++L W Q QP +L
Sbjct: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
Query: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317
SLL K +LPE+S LI A+Q L + +++LGFSES +K YF +F ++ +A
Sbjct: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
Query: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377
++ F V+ N L+ LC P+ WL CTC+ Q+++R E L + S+ TT L +L +
Sbjct: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
Query: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437
A Q P+ L+ LC+LAAEGIW +FS DLR++GL + ++ M +LQ
Sbjct: 561 A--QPLGPQ-----LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
Query: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493
++F+HLC QEF AAM Y+L+ K + ++ + L GI
Sbjct: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
Query: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545
F+ G+ ++E +E F LS+ + + Q + SL E
Sbjct: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
Query: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605
L+ET+ K F+T+VM FEE+ + + L++ +FC+K +H+ L++
Sbjct: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
Query: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665
I ++ S P++ +L R +
Sbjct: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
Query: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
T Y+ LF + +LK L L G SLS S ++ LC+TL+ P C +E L L C
Sbjct: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
Query: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
+++E C+D+A L N L L L N L D G LC+ L+ C L+RL L+ C LTS
Sbjct: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
Query: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSC 845
C ++ VL S SL LDL N L+D GV LC L+HP C + L L L+ +
Sbjct: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMR 968
Query: 846 KDIAAV 851
+++ A+
Sbjct: 969 QELRAL 974
Score = 136 bits (342), Expect = 1e-31
Identities = 73/181 (40%), Positives = 104/181 (57%)
Query: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
VL +++L LDL N+L + V SLC L+ P C + L L GC LT++ CKD+A L
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
Query: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
N L L L N + D G + LC L+ P CKL+ L L +C +T CC D+A+ L A
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
Query: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLT 973
+L+ L+L LD V +LCE L HP C L LGL ++ +E ++ L ++E++ P L
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQLL 982
Query: 974 I 974
I
Sbjct: 983 I 983
Score = 124 bits (310), Expect = 6e-28
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
SVL LK L L N L + LC+ L+ C LE L L C LT+ C ++ L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
+++L+ LDL N L D G LC L+ P C ++ L L+ C LTSD C+D+A+VL +
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGL 892
LK L L N + D GVR LC L+HP CKL LGL
Sbjct: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGL 958
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/123 (35%), Positives = 57/123 (46%)
Query: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
+VL LK L L N + + V+ LC L+ P C LE L L C +T C D+A L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969
A +TL L+L + L LC+ L P C LQ L L G + + L SV
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 970 PHL 972
P L
Sbjct: 922 PSL 924
Score = 38.9 bits (89), Expect = 0.024
Identities = 25/80 (31%), Positives = 41/80 (51%)
Query: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
L YL+ L+KEE +F+ LL A+ +K S +VA L Y ++AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 VTLNLFLQINRKDLWTKAQE 90
+ L+ + Q+ + L +AQE
Sbjct: 69 LALHTWEQMGLRSLCAQAQE 88
Score = 34.3 bits (77), Expect = 0.59
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955
P+T A + + L + L+ L+L +L AV LC+ L P C L+ L L G
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 956 EETQKIL 962
E K L
Sbjct: 851 AEDCKDL 857
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 337 bits (863), Expect = 4e-92
Identities = 254/828 (30%), Positives = 386/828 (46%), Gaps = 107/828 (12%)
Query: 26 FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85
+ E+ ++ EK E PWA + + L H+P WE ++ L W
Sbjct: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
Query: 86 TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141
E+ K R H + L+ P+ Y E + E+ D +
Sbjct: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
Query: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198
V+L+G GIGK+TL R+V W G L+ DRF VF+ + E+ SL
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
Query: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257
EL+ +D + I I S+PER+LFI+DG ++ + LQ ++L W Q QP +L
Sbjct: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
Query: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317
SLL K +LPE+S LI A+Q L + +++LGFSES +K YF +F ++ +A
Sbjct: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
Query: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377
++ F V+ N L+ LC P+ WL CTC+ Q+++R E L + S+ TT L +L +
Sbjct: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
Query: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437
A Q P+ L+ LC+LAAEGIW +FS DLR++GL + ++ M +LQ
Sbjct: 561 A--QPLGPQ-----LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
Query: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493
++F+HLC QEF AAM Y+L+ K + ++ + L GI
Sbjct: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
Query: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545
F+ G+ ++E +E F LS+ + + Q + SL E
Sbjct: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
Query: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605
L+ET+ K F+T+VM FEE+ + + L++ +FC+K +H+ L++
Sbjct: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
Query: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665
I ++ S P++ +L R +
Sbjct: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
Query: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
T Y+ LF + +LK L L G SLS S ++ LC+TL+ P C +E L L C
Sbjct: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
Query: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
+++E C+D+A L N L L L N L D G LC+ L+ C L+RL L+ C LTS
Sbjct: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
Query: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIREL 833
C ++ VL S SL LDL N L+D GV LC L+HP C + L
Sbjct: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 124 bits (310), Expect = 6e-28
Identities = 66/155 (42%), Positives = 88/155 (56%)
Query: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
VL +++L LDL N+L + V SLC L+ P C + L L GC LT++ CKD+A L
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
Query: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
N L L L N + D G + LC L+ P CKL+ L L +C +T CC D+A+ L A
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
Query: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLG 948
+L+ L+L LD V +LCE L HP C L LG
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 122 bits (306), Expect = 2e-27
Identities = 66/156 (42%), Positives = 86/156 (55%)
Query: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
SVL LK L L N L + LC+ L+ C LE L L C LT+ C ++ L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
+++L+ LDL N L D G LC L+ P C ++ L L+ C LTSD C+D+A+VL +
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLG 891
LK L L N + D GVR LC L+HP CKL LG
Sbjct: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/123 (35%), Positives = 57/123 (46%)
Query: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
+VL LK L L N + + V+ LC L+ P C LE L L C +T C D+A L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969
A +TL L+L + L LC+ L P C LQ L L G + + L SV
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 970 PHL 972
P L
Sbjct: 922 PSL 924
Score = 38.9 bits (89), Expect = 0.024
Identities = 25/80 (31%), Positives = 41/80 (51%)
Query: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
L YL+ L+KEE +F+ LL A+ +K S +VA L Y ++AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 VTLNLFLQINRKDLWTKAQE 90
+ L+ + Q+ + L +AQE
Sbjct: 69 LALHTWEQMGLRSLCAQAQE 88
Score = 34.3 bits (77), Expect = 0.59
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955
P+T A + + L + L+ L+L +L AV LC+ L P C L+ L L G
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 956 EETQKIL 962
E K L
Sbjct: 851 AEDCKDL 857
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 337 bits (863), Expect = 4e-92
Identities = 254/828 (30%), Positives = 386/828 (46%), Gaps = 107/828 (12%)
Query: 26 FKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTLNLFLQINRKDLW 85
+ E+ ++ EK E PWA + + L H+P WE ++ L W
Sbjct: 216 YTEIREREREKSEKGRPPWAAVVGTPPQAHTSLQPHHHP----WEPSVRESLC----STW 267
Query: 86 TKAQEEMRNKLNPY----RKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA 141
E+ K R H + L+ P+ Y E + E+ D +
Sbjct: 268 PWKNEDFNQKFTQLLLLQRPHPRSQDPLVKRSW-----PD--YVEENRGHLIEIRDLFGP 320
Query: 142 AA---RRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSL 198
V+L+G GIGK+TL R+V W G L+ DRF VF+ + E+ SL
Sbjct: 321 GLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSL 380
Query: 199 LELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIIL 257
EL+ +D + I I S+PER+LFI+DG ++ + LQ ++L W Q QP +L
Sbjct: 381 AELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALL 440
Query: 258 SSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKA 317
SLL K +LPE+S LI A+Q L + +++LGFSES +K YF +F ++ +A
Sbjct: 441 GSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQA 500
Query: 318 LKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFK 377
++ F V+ N L+ LC P+ WL CTC+ Q+++R E L + S+ TT L +L +
Sbjct: 501 IRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQALQ 560
Query: 378 AGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRR 437
A Q P+ L+ LC+LAAEGIW +FS DLR++GL + ++ M +LQ
Sbjct: 561 A--QPLGPQ-----LRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQEH 613
Query: 438 GD--CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGI-- 493
++F+HLC QEF AAM Y+L+ K + ++ + L GI
Sbjct: 614 PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS---------NCIIDLEKTLEAYGIHG 664
Query: 494 --------FMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQEL 545
F+ G+ ++E +E F LS+ + + Q + SL E
Sbjct: 665 LFGASTTRFLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL----ES 718
Query: 546 FIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDD 605
L+ET+ K F+T+VM FEE+ + + L++ +FC+K +H+ L++
Sbjct: 719 LHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQL--------- 769
Query: 606 SGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI 665
I ++ S P++ +L R +
Sbjct: 770 ----------------------------IEGRQHRSTWSPTMVVL----------FRWVP 791
Query: 666 FTSVYFGHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
T Y+ LF + +LK L L G SLS S ++ LC+TL+ P C +E L L C
Sbjct: 792 VTDAYW---QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCG 848
Query: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
+++E C+D+A L N L L L N L D G LC+ L+ C L+RL L+ C LTS
Sbjct: 849 LTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTS 908
Query: 786 VSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIREL 833
C ++ VL S SL LDL N L+D GV LC L+HP C + L
Sbjct: 909 DCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 124 bits (310), Expect = 6e-28
Identities = 66/155 (42%), Positives = 88/155 (56%)
Query: 794 VLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLI 853
VL +++L LDL N+L + V SLC L+ P C + L L GC LT++ CKD+A L
Sbjct: 803 VLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLR 862
Query: 854 CNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACK 913
N L L L N + D G + LC L+ P CKL+ L L +C +T CC D+A+ L A
Sbjct: 863 ANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASP 922
Query: 914 TLRSLNLDWIALDADAVVVLCEALSHPDCALQMLG 948
+L+ L+L LD V +LCE L HP C L LG
Sbjct: 923 SLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 122 bits (306), Expect = 2e-27
Identities = 66/156 (42%), Positives = 86/156 (55%)
Query: 736 SVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVL 795
SVL LK L L N L + LC+ L+ C LE L L C LT+ C ++ L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 796 LCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICN 855
+++L+ LDL N L D G LC L+ P C ++ L L+ C LTSD C+D+A+VL +
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 856 GKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLG 891
LK L L N + D GVR LC L+HP CKL LG
Sbjct: 922 PSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 69.7 bits (169), Expect = 1e-11
Identities = 44/123 (35%), Positives = 57/123 (46%)
Query: 850 AVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAAL 909
+VL LK L L N + + V+ LC L+ P C LE L L C +T C D+A L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 910 IACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKI 969
A +TL L+L + L LC+ L P C LQ L L G + + L SV
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 970 PHL 972
P L
Sbjct: 922 PSL 924
Score = 38.9 bits (89), Expect = 0.024
Identities = 25/80 (31%), Positives = 41/80 (51%)
Query: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
L YL+ L+KEE +F+ LL A+ +K S +VA L Y ++AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 VTLNLFLQINRKDLWTKAQE 90
+ L+ + Q+ + L +AQE
Sbjct: 69 LALHTWEQMGLRSLCAQAQE 88
Score = 34.3 bits (77), Expect = 0.59
Identities = 22/67 (32%), Positives = 31/67 (46%)
Query: 896 PITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFD 955
P+T A + + L + L+ L+L +L AV LC+ L P C L+ L L G
Sbjct: 791 PVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLT 850
Query: 956 EETQKIL 962
E K L
Sbjct: 851 AEDCKDL 857
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 241 bits (614), Expect = 3e-63
Identities = 227/858 (26%), Positives = 381/858 (44%), Gaps = 89/858 (10%)
Query: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
LL L+EL +E+ +F+ L+ + + IPW L++A D+A+ L + Y + A E
Sbjct: 22 LLAALEELSQEQLKRFRHKLRDVGP--DGRSIPWGRLERADAVDLAEQLAQFYGPEPALE 79
Query: 71 VTLNLFLQINRKDLWTKAQEEMRNKL--------------NPYRKHMKETFQLIWEKET- 115
V + + +D+ + QE +L YR+H+ + + E+
Sbjct: 80 VARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKERNAR 139
Query: 116 CLHVPEHFYKETMKNEYKELNDAYTAA-------ARRH-------------------TVV 149
+ + + F K + E +A A ARR TVV
Sbjct: 140 SVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVV 199
Query: 150 LEGPDGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAET-SLLELLSRDWPE 208
L+GP GIGKT +K++ DWA G L++ + F FF+ E+ T SL +L+ P+
Sbjct: 200 LQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPD 259
Query: 209 SSEKIEDIFSQPERILFIMDGFEQLKFNLQLKADLSDDWRQRQPMPIILSSLLQKKMLPE 268
+ + +QP+R+LFI+DG ++L +A D + +L LL K +LP
Sbjct: 260 RGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVLGGLLSKALLPT 319
Query: 269 SSLLIALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNG 328
+ LL+ A + L P+ ++ GFS+ +KK YF FF ++ +A + + FV++N
Sbjct: 320 ALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKENE 379
Query: 329 PLFILCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVN 388
LF LC PF CW+VCT ++Q+LE G DL S+ TT +Y F+T+V + + P++
Sbjct: 380 TLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADGPRL- 438
Query: 389 RARLKSLCALAAEGIWTYTFVFSHGDLRRNGLSESE-GVMWVGMRLLQ---RRGDCFAFM 444
+ L++LC LA EG+ F+ +L + L S+ +++ + L + F+
Sbjct: 439 QGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQFI 498
Query: 445 HLCIQEFCAAMFYLLKRPKDDPNPAIGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIV 504
QEF AA+ YLL+ P A G + L+R QP + L F+FG+ + E +
Sbjct: 499 DQSFQEFLAALSYLLE-DGGVPRTAAGGVGTLLRGD-AQPHSHLVLTTRFLFGLLSAERM 556
Query: 505 SMLETSFGFPLSKDLKQ------------------EITQCLESLSQCEADREAIAFQ--- 543
+E FG +S+ +KQ E+T+ + L E E +
Sbjct: 557 RDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGEEPN 616
Query: 544 ---ELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIA--SFCLKHCQHLTTLRMCV 598
EL L+ETQE FV + + F E+ + + +A S+C++ C LR+
Sbjct: 617 YPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALRLIS 676
Query: 599 ENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPV 658
+ + +K + R S+ + + SL P L +A+ P+
Sbjct: 677 CRLV-----AAQEKKKKSLGKRLQASLGGGSSSQGTTKQLPASLLHP----LFQAMTDPL 727
Query: 659 CKLRKLIFTSVYFGHD--SELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKI 716
C L L + +L +A+ P L L L LS++ +R L E L P C++
Sbjct: 728 CHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQCRV 787
Query: 717 EELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERL 776
+ + + D + + +L + L L L L +T LC L+H C L+ L
Sbjct: 788 QTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQTL 846
Query: 777 MLMYCCLTSVSCDSISEV 794
L L+ S + V
Sbjct: 847 SLASVELSEQSLQELQAV 864
Score = 75.5 bits (184), Expect = 2e-13
Identities = 61/225 (27%), Positives = 91/225 (40%), Gaps = 20/225 (8%)
Query: 771 CALERLMLMYC--------CLTSVSCDSISEVLLCSKSLSL---LDLGSNALEDNGVASL 819
C ++ +L YC L +SC ++ KSL LG + L
Sbjct: 652 CRMDVAVLSYCVRCCPAGQALRLISCRLVAAQEKKKKSLGKRLQASLGGGSSSQGTTKQL 711
Query: 820 CAALKHPG--------CSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDT 871
A+L HP C + L L C L C+D++ L L L L HN + +
Sbjct: 712 PASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEA 771
Query: 872 GVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVV 931
G+R L L P C+++ + +Q P + + L L +L+L L A V
Sbjct: 772 GLRMLSEGLAWPQCRVQTVRVQ-LPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVT 830
Query: 932 VLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTISH 976
LC L H C LQ L L E++ + L +V+ P L I+H
Sbjct: 831 YLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITH 875
Score = 69.3 bits (168), Expect = 2e-11
Identities = 49/169 (28%), Positives = 75/169 (44%), Gaps = 9/169 (5%)
Query: 691 SLYGTSLSQSDIRHLCETLKHPM--------CKIEELILGKCDISSEVCEDIASVLACNS 742
SL G S SQ + L +L HP+ C + L L C + VC D++ L
Sbjct: 697 SLGGGSSSQGTTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAP 756
Query: 743 KLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLS 802
L L L+ N L + G+ +L E L C ++ + + + +L S +L+
Sbjct: 757 ALTELGLLHNRLSEAGLRMLSEGLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALT 815
Query: 803 LLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAV 851
LDL L V LCA L+H GC ++ L L L+ S +++ AV
Sbjct: 816 TLDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAV 864
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 206 bits (525), Expect = 7e-53
Identities = 160/574 (27%), Positives = 281/574 (48%), Gaps = 36/574 (6%)
Query: 11 LLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWE 70
LLW L +L + +F K K L+ P+ EL+ D+A+LL Y K+A +
Sbjct: 13 LLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVK 72
Query: 71 VTLNLFLQINRKDLWTKAQEE-MRNKLNPYRKHMK------------ETFQLIWEKETCL 117
V L +N +L + + + YR+H++ Q++ +
Sbjct: 73 VVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSS 132
Query: 118 HVPEHFYKETMKNEYKELN-DAYTAAARRHT-----VVLEGPDGIGKTTLLRKVMLDWAE 171
PE + E + + +A + + + VVL+G G GKTTL RK++LDWA
Sbjct: 133 ESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWAT 192
Query: 172 GNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFE 231
G L+ RF +VF+++ E+ + E+ L +LL ++ + +I QPER+LFI+DGF+
Sbjct: 193 GTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFD 252
Query: 232 QLK--FNLQLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRH 289
+L+ F +LK R P +L L+++ LP SLLI LA++ +L+
Sbjct: 253 ELQRPFEEKLKK------RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQ 306
Query: 290 PKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQ 349
+ + +LGFSE E+ YFS +F ++ +A + F+ V+ N L+ C P CW+VC+ ++
Sbjct: 307 ARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQG 366
Query: 350 RLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRAR-LKSLCALAAEGIWTYTF 408
++ERG+ + +N+T ++ ++++T +++R R L+SLC+LAAEGI F
Sbjct: 367 QMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRF 426
Query: 409 VFSHGDLRRNGLSESEGVMWVGMRLLQ---RRGDCFAFMHLCIQEFCAAMFYLLKRPKDD 465
+F +LR++ L ++ Q ++F H+ Q+F AM YL+K +
Sbjct: 427 LFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSR 486
Query: 466 -PNPAIGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEIT 524
+ + +L+ + +T F+ IS ++ S LE F F +S L Q++
Sbjct: 487 LGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLK 546
Query: 525 QCLESLSQCEADREAIAFQELFIGLFETQEKEFV 558
E + + +R +L L+E + K V
Sbjct: 547 HFKEQMESMKHNRT----WDLEFSLYEAKIKNLV 576
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 199 bits (505), Expect = 1e-50
Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679
L S T Q L + + L D L +LC+ L P C+L KL + S+ L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739
+ P K L++ ++++ +R LC+ LK C++E L L C ++S+ C D+ ++A
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
+ L+ L+L N L D GM LC L H L L + C +T+ C + VL +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
SL L L N L D G LC L PGC + LW+ C T+ C ++VL N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919
L++ +N + D GVR+LC L P L L L C ++ + C +AA L+A +LR L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
L L ++ L E++ P C L+ L L+ + EE + L ++E+ P L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 194 bits (493), Expect = 3e-49
Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)
Query: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678
+++ S N L++ + L D + + + L P CK++KL + G +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
+ L P L+ L L L + ++ LCE L P C++E+L L C +S+ CE +ASV
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
L K L++ N + + G+ +LC+ LK S C LE L L C +TS +C + ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
SL L LGSN L D G+A LC L HP +R LW+ C +T+ C D+ VL
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
LK L L NE+GD G R LC L P C+LE L +++C T ACC ++ L + L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
L + L+ V LC+ L P L++L L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 179 bits (455), Expect = 9e-45
Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)
Query: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690
+ Q LD++ L D A L L Q C++ +L + ++ A+ NP L L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
Query: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
+L L + + + L+ P CKI++L L C ++ C ++S L L+ L L
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
+N L D G+ LLCE L C LE+L L YC L++ SC+ ++ VL L + +N
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870
+ + GV LC LK C + L L C +TSD+C+D+ ++ L+ L LG N++GD
Sbjct: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
Query: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930
G+ +LC L HP +L L + C IT C D+ L A ++L+ L+L L +
Sbjct: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
Query: 931 VVLCEALSHPDCALQMLGLHKSGF 954
+LCE L P C L+ L + F
Sbjct: 302 RLLCETLLEPGCQLESLWVKSCSF 325
Score = 103 bits (258), Expect = 6e-22
Identities = 61/185 (32%), Positives = 92/185 (49%)
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
C LT C IS L + +L+ L+L SN L D GV + L+ P C I++L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
T C +++ L L+ L L N +GD G++ LC L P C+LE L L+ C ++ A
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
C+ +A+ L A + L + ++ V VLC+ L C L+ L L G + +
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
Query: 961 ILMSV 965
L +
Sbjct: 218 DLCGI 222
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 199 bits (505), Expect = 1e-50
Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679
L S T Q L + + L D L +LC+ L P C+L KL + S+ L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739
+ P K L++ ++++ +R LC+ LK C++E L L C ++S+ C D+ ++A
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
+ L+ L+L N L D GM LC L H L L + C +T+ C + VL +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
SL L L N L D G LC L PGC + LW+ C T+ C ++VL N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919
L++ +N + D GVR+LC L P L L L C ++ + C +AA L+A +LR L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
L L ++ L E++ P C L+ L L+ + EE + L ++E+ P L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 194 bits (493), Expect = 3e-49
Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)
Query: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678
+++ S N L++ + L D + + + L P CK++KL + G +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
+ L P L+ L L L + ++ LCE L P C++E+L L C +S+ CE +ASV
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
L K L++ N + + G+ +LC+ LK S C LE L L C +TS +C + ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
SL L LGSN L D G+A LC L HP +R LW+ C +T+ C D+ VL
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
LK L L NE+GD G R LC L P C+LE L +++C T ACC ++ L + L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
L + L+ V LC+ L P L++L L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 179 bits (455), Expect = 9e-45
Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)
Query: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690
+ Q LD++ L D A L L Q C++ +L + ++ A+ NP L L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
Query: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
+L L + + + L+ P CKI++L L C ++ C ++S L L+ L L
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
+N L D G+ LLCE L C LE+L L YC L++ SC+ ++ VL L + +N
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870
+ + GV LC LK C + L L C +TSD+C+D+ ++ L+ L LG N++GD
Sbjct: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
Query: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930
G+ +LC L HP +L L + C IT C D+ L A ++L+ L+L L +
Sbjct: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
Query: 931 VVLCEALSHPDCALQMLGLHKSGF 954
+LCE L P C L+ L + F
Sbjct: 302 RLLCETLLEPGCQLESLWVKSCSF 325
Score = 103 bits (258), Expect = 6e-22
Identities = 61/185 (32%), Positives = 92/185 (49%)
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
C LT C IS L + +L+ L+L SN L D GV + L+ P C I++L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
T C +++ L L+ L L N +GD G++ LC L P C+LE L L+ C ++ A
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
C+ +A+ L A + L + ++ V VLC+ L C L+ L L G + +
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
Query: 961 ILMSV 965
L +
Sbjct: 218 DLCGI 222
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 199 bits (505), Expect = 1e-50
Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679
L S T Q L + + L D L +LC+ L P C+L KL + S+ L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739
+ P K L++ ++++ +R LC+ LK C++E L L C ++S+ C D+ ++A
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
+ L+ L+L N L D GM LC L H L L + C +T+ C + VL +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
SL L L N L D G LC L PGC + LW+ C T+ C ++VL N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919
L++ +N + D GVR+LC L P L L L C ++ + C +AA L+A +LR L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
L L ++ L E++ P C L+ L L+ + EE + L ++E+ P L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 194 bits (493), Expect = 3e-49
Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)
Query: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678
+++ S N L++ + L D + + + L P CK++KL + G +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
+ L P L+ L L L + ++ LCE L P C++E+L L C +S+ CE +ASV
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
L K L++ N + + G+ +LC+ LK S C LE L L C +TS +C + ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
SL L LGSN L D G+A LC L HP +R LW+ C +T+ C D+ VL
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
LK L L NE+GD G R LC L P C+LE L +++C T ACC ++ L + L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
L + L+ V LC+ L P L++L L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 179 bits (455), Expect = 9e-45
Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)
Query: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690
+ Q LD++ L D A L L Q C++ +L + ++ A+ NP L L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
Query: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
+L L + + + L+ P CKI++L L C ++ C ++S L L+ L L
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
+N L D G+ LLCE L C LE+L L YC L++ SC+ ++ VL L + +N
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870
+ + GV LC LK C + L L C +TSD+C+D+ ++ L+ L LG N++GD
Sbjct: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
Query: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930
G+ +LC L HP +L L + C IT C D+ L A ++L+ L+L L +
Sbjct: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
Query: 931 VVLCEALSHPDCALQMLGLHKSGF 954
+LCE L P C L+ L + F
Sbjct: 302 RLLCETLLEPGCQLESLWVKSCSF 325
Score = 103 bits (258), Expect = 6e-22
Identities = 61/185 (32%), Positives = 92/185 (49%)
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
C LT C IS L + +L+ L+L SN L D GV + L+ P C I++L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
T C +++ L L+ L L N +GD G++ LC L P C+LE L L+ C ++ A
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
C+ +A+ L A + L + ++ V VLC+ L C L+ L L G + +
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
Query: 961 ILMSV 965
L +
Sbjct: 218 DLCGI 222
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 199 bits (505), Expect = 1e-50
Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679
L S T Q L + + L D L +LC+ L P C+L KL + S+ L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739
+ P K L++ ++++ +R LC+ LK C++E L L C ++S+ C D+ ++A
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
+ L+ L+L N L D GM LC L H L L + C +T+ C + VL +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
SL L L N L D G LC L PGC + LW+ C T+ C ++VL N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919
L++ +N + D GVR+LC L P L L L C ++ + C +AA L+A +LR L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
L L ++ L E++ P C L+ L L+ + EE + L ++E+ P L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 194 bits (493), Expect = 3e-49
Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)
Query: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678
+++ S N L++ + L D + + + L P CK++KL + G +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
+ L P L+ L L L + ++ LCE L P C++E+L L C +S+ CE +ASV
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
L K L++ N + + G+ +LC+ LK S C LE L L C +TS +C + ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
SL L LGSN L D G+A LC L HP +R LW+ C +T+ C D+ VL
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
LK L L NE+GD G R LC L P C+LE L +++C T ACC ++ L + L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
L + L+ V LC+ L P L++L L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 179 bits (455), Expect = 9e-45
Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)
Query: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690
+ Q LD++ L D A L L Q C++ +L + ++ A+ NP L L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
Query: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
+L L + + + L+ P CKI++L L C ++ C ++S L L+ L L
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
+N L D G+ LLCE L C LE+L L YC L++ SC+ ++ VL L + +N
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870
+ + GV LC LK C + L L C +TSD+C+D+ ++ L+ L LG N++GD
Sbjct: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
Query: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930
G+ +LC L HP +L L + C IT C D+ L A ++L+ L+L L +
Sbjct: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
Query: 931 VVLCEALSHPDCALQMLGLHKSGF 954
+LCE L P C L+ L + F
Sbjct: 302 RLLCETLLEPGCQLESLWVKSCSF 325
Score = 103 bits (258), Expect = 6e-22
Identities = 61/185 (32%), Positives = 92/185 (49%)
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
C LT C IS L + +L+ L+L SN L D GV + L+ P C I++L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
T C +++ L L+ L L N +GD G++ LC L P C+LE L L+ C ++ A
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
C+ +A+ L A + L + ++ V VLC+ L C L+ L L G + +
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
Query: 961 ILMSV 965
L +
Sbjct: 218 DLCGI 222
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 199 bits (505), Expect = 1e-50
Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679
L S T Q L + + L D L +LC+ L P C+L KL + S+ L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739
+ P K L++ ++++ +R LC+ LK C++E L L C ++S+ C D+ ++A
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
+ L+ L+L N L D GM LC L H L L + C +T+ C + VL +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
SL L L N L D G LC L PGC + LW+ C T+ C ++VL N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919
L++ +N + D GVR+LC L P L L L C ++ + C +AA L+A +LR L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
L L ++ L E++ P C L+ L L+ + EE + L ++E+ P L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 194 bits (493), Expect = 3e-49
Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)
Query: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678
+++ S N L++ + L D + + + L P CK++KL + G +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
+ L P L+ L L L + ++ LCE L P C++E+L L C +S+ CE +ASV
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
L K L++ N + + G+ +LC+ LK S C LE L L C +TS +C + ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
SL L LGSN L D G+A LC L HP +R LW+ C +T+ C D+ VL
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
LK L L NE+GD G R LC L P C+LE L +++C T ACC ++ L + L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
L + L+ V LC+ L P L++L L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 179 bits (455), Expect = 9e-45
Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)
Query: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690
+ Q LD++ L D A L L Q C++ +L + ++ A+ NP L L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
Query: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
+L L + + + L+ P CKI++L L C ++ C ++S L L+ L L
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
+N L D G+ LLCE L C LE+L L YC L++ SC+ ++ VL L + +N
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870
+ + GV LC LK C + L L C +TSD+C+D+ ++ L+ L LG N++GD
Sbjct: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
Query: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930
G+ +LC L HP +L L + C IT C D+ L A ++L+ L+L L +
Sbjct: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
Query: 931 VVLCEALSHPDCALQMLGLHKSGF 954
+LCE L P C L+ L + F
Sbjct: 302 RLLCETLLEPGCQLESLWVKSCSF 325
Score = 103 bits (258), Expect = 6e-22
Identities = 61/185 (32%), Positives = 92/185 (49%)
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
C LT C IS L + +L+ L+L SN L D GV + L+ P C I++L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
T C +++ L L+ L L N +GD G++ LC L P C+LE L L+ C ++ A
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
C+ +A+ L A + L + ++ V VLC+ L C L+ L L G + +
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
Query: 961 ILMSV 965
L +
Sbjct: 218 DLCGI 222
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 199 bits (505), Expect = 1e-50
Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)
Query: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679
L S T Q L + + L D L +LC+ L P C+L KL + S+ L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739
+ P K L++ ++++ +R LC+ LK C++E L L C ++S+ C D+ ++A
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
+ L+ L+L N L D GM LC L H L L + C +T+ C + VL +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
SL L L N L D G LC L PGC + LW+ C T+ C ++VL N L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919
L++ +N + D GVR+LC L P L L L C ++ + C +AA L+A +LR L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
L L ++ L E++ P C L+ L L+ + EE + L ++E+ P L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 194 bits (493), Expect = 3e-49
Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)
Query: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678
+++ S N L++ + L D + + + L P CK++KL + G +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
+ L P L+ L L L + ++ LCE L P C++E+L L C +S+ CE +ASV
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
L K L++ N + + G+ +LC+ LK S C LE L L C +TS +C + ++
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
SL L LGSN L D G+A LC L HP +R LW+ C +T+ C D+ VL
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
LK L L NE+GD G R LC L P C+LE L +++C T ACC ++ L + L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
L + L+ V LC+ L P L++L L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 179 bits (455), Expect = 9e-45
Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)
Query: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690
+ Q LD++ L D A L L Q C++ +L + ++ A+ NP L L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
Query: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
+L L + + + L+ P CKI++L L C ++ C ++S L L+ L L
Sbjct: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
Query: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
+N L D G+ LLCE L C LE+L L YC L++ SC+ ++ VL L + +N
Sbjct: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
Query: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870
+ + GV LC LK C + L L C +TSD+C+D+ ++ L+ L LG N++GD
Sbjct: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
Query: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930
G+ +LC L HP +L L + C IT C D+ L A ++L+ L+L L +
Sbjct: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
Query: 931 VVLCEALSHPDCALQMLGLHKSGF 954
+LCE L P C L+ L + F
Sbjct: 302 RLLCETLLEPGCQLESLWVKSCSF 325
Score = 103 bits (258), Expect = 6e-22
Identities = 61/185 (32%), Positives = 92/185 (49%)
Query: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
C LT C IS L + +L+ L+L SN L D GV + L+ P C I++L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
T C +++ L L+ L L N +GD G++ LC L P C+LE L L+ C ++ A
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
C+ +A+ L A + L + ++ V VLC+ L C L+ L L G + +
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
Query: 961 ILMSV 965
L +
Sbjct: 218 DLCGI 222
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,686,295
Number of Sequences: 37866
Number of extensions: 1662017
Number of successful extensions: 6398
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 29
Number of HSP's that attempted gapping in prelim test: 5555
Number of HSP's gapped (non-prelim): 285
length of query: 991
length of database: 18,247,518
effective HSP length: 112
effective length of query: 879
effective length of database: 14,006,526
effective search space: 12311736354
effective search space used: 12311736354
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.