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Search of human proteins with 122937434
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937434 Rho-guanine nucleotide exchange factor [Homo
sapiens]
(1651 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 3288 0.0
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 639 0.0
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 638 0.0
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 588 e-167
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 588 e-167
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 571 e-162
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 514 e-145
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 510 e-144
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 509 e-143
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 169 3e-41
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 169 3e-41
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 167 6e-41
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 150 8e-36
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 150 8e-36
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 150 8e-36
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 88 6e-17
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 88 6e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 79 5e-14
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom... 78 8e-14
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 77 2e-13
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 75 5e-13
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 75 5e-13
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 71 1e-11
gi|83715966 hypothetical protein LOC389337 [Homo sapiens] 69 4e-11
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 68 8e-11
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 68 8e-11
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 67 1e-10
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 67 2e-10
gi|24797153 faciogenital dysplasia protein [Homo sapiens] 66 3e-10
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 65 4e-10
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 3288 bits (8525), Expect = 0.0
Identities = 1651/1651 (100%), Positives = 1651/1651 (100%)
Query: 1 MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP 60
MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP
Sbjct: 1 MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP 60
Query: 61 GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT 120
GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT
Sbjct: 61 GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT 120
Query: 121 PFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQ 180
PFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQ
Sbjct: 121 PFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQ 180
Query: 181 FFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASL 240
FFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASL
Sbjct: 181 FFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASL 240
Query: 241 HYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAE 300
HYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAE
Sbjct: 241 HYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAE 300
Query: 301 TEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAA 360
TEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAA
Sbjct: 301 TEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAA 360
Query: 361 GRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPT 420
GRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPT
Sbjct: 361 GRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPT 420
Query: 421 ETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLD 480
ETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLD
Sbjct: 421 ETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLD 480
Query: 481 ALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSS 540
ALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSS
Sbjct: 481 ALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSS 540
Query: 541 NLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQE 600
NLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQE
Sbjct: 541 NLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQE 600
Query: 601 EEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTF 660
EEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTF
Sbjct: 601 EEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTF 660
Query: 661 SGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSS 720
SGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSS
Sbjct: 661 SGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSS 720
Query: 721 FRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH 780
FRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH
Sbjct: 721 FRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH 780
Query: 781 NSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFC 840
NSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFC
Sbjct: 781 NSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFC 840
Query: 841 NRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDEL 900
NRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDEL
Sbjct: 841 NRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDEL 900
Query: 901 LEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKE 960
LEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKE
Sbjct: 901 LEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKE 960
Query: 961 AVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKER 1020
AVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKER
Sbjct: 961 AVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKER 1020
Query: 1021 TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL 1080
TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL
Sbjct: 1021 TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL 1080
Query: 1081 MSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQK 1140
MSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQK
Sbjct: 1081 MSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQK 1140
Query: 1141 LIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSE 1200
LIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSE
Sbjct: 1141 LIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSE 1200
Query: 1201 SDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLI 1260
SDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLI
Sbjct: 1201 SDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLI 1260
Query: 1261 KPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPG 1320
KPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPG
Sbjct: 1261 KPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPG 1320
Query: 1321 SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT 1380
SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT
Sbjct: 1321 SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT 1380
Query: 1381 RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANV 1440
RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANV
Sbjct: 1381 RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANV 1440
Query: 1441 HQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEY 1500
HQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEY
Sbjct: 1441 HQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEY 1500
Query: 1501 QHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLC 1560
QHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLC
Sbjct: 1501 QHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLC 1560
Query: 1561 HENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPS 1620
HENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPS
Sbjct: 1561 HENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPS 1620
Query: 1621 NVSHKLWTAAGSGHQILPFHESSKDSCKNGN 1651
NVSHKLWTAAGSGHQILPFHESSKDSCKNGN
Sbjct: 1621 NVSHKLWTAAGSGHQILPFHESSKDSCKNGN 1651
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
[Homo sapiens]
Length = 1173
Score = 639 bits (1647), Expect = 0.0
Identities = 378/838 (45%), Positives = 522/838 (62%), Gaps = 46/838 (5%)
Query: 733 PSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDEL 792
P+ S VG+ ++ G S + PGT L T E+D + + +D+
Sbjct: 151 PALSRNVGMTVSQKG--GPQPTPSPAGPGTQLGPI----TGEMDEADSAFLKFKQTADDS 204
Query: 793 LQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQD 852
L +SP+TES +ED +SL S++ SD EFEAESWSL VD ++ +Q+++V+KRQD
Sbjct: 205 LSL--TSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQD 262
Query: 853 VIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMK 912
V++ELMQTE+HH++TL IM +++ + ++EELQ + ++FPC D+LLE H HF +K
Sbjct: 263 VLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLK 322
Query: 913 ERRQESCA-GSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQ 970
ERRQES GSDRN+VI +IGD+LVQQFS EN +MK+ YG FC H EAV+ +K L QQ
Sbjct: 323 ERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQ 382
Query: 971 NKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKA 1030
NKKFQN IK + + RR G+ ECILLVTQRITKYPVLVERI+Q T+ TE+++DL +A
Sbjct: 383 NKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQA 442
Query: 1031 LCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYD 1090
L LIKD+I+ VD KV+E EK Q+ EI K++ K+ +KLKNG FRK+ ++ +R L +
Sbjct: 443 LNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDML--QRQLHLE 500
Query: 1091 GLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEE 1150
G++ WKT +GR KDILA+LLTDVLL LQEKDQKY+FA+VD KP VISLQKLI REVANEE
Sbjct: 501 GMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEE 560
Query: 1151 RGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEA 1210
+ MFLISAS GPEMYEI+T+SKE+RN WM IQ+AVESCP+E+ G S +E+++ EA
Sbjct: 561 KAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEA 620
Query: 1211 RVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQA 1270
R +++ QE L+ +DQ I L EK IY E+ E+ G ED+ L DP E Q
Sbjct: 621 RATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQG 680
Query: 1271 ASLLAAALKEAESLQVAVKASQMGAVSQSCED---SCGDSVLADTLSSHDVPGSPTASLV 1327
+L +A+ E E +Q + Q+G+ + ED S G A+T + +D SPT +
Sbjct: 681 ELILKSAMSEIEGIQSLI-CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKN-- 737
Query: 1328 TGGREGRGCSDVDPGIQG-----VVTDLAVSDAG------EKVECRNFPGSS-------- 1368
G + S DP + DL +SD+ E + PG+
Sbjct: 738 --GSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTV 795
Query: 1369 -QSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKS 1427
+SE++Q IQ L++LL +LQA + QDS++E R +Q++E S L+ ++
Sbjct: 796 LESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQ 855
Query: 1428 RDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLL 1487
R+ ++Q EE A + +LQ QL+ EQ+RW R + Q + + LQERE E + E L
Sbjct: 856 RNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLE 915
Query: 1488 RSRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLP 1545
+ R EL+ Q Q YQH LERLRE QR VERE+ R+ + L +Q + P L P
Sbjct: 916 QERAELERQRQAYQHDLERLREAQRAVERERERLELLRRL------KKQNTAPGALPP 967
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 638 bits (1646), Expect = 0.0
Identities = 372/811 (45%), Positives = 511/811 (63%), Gaps = 44/811 (5%)
Query: 760 PGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDL 819
PGT L T E+D + + +D+ L +SP+TES +ED +SL S++
Sbjct: 18 PGTQLGPI----TGEMDEADSAFLKFKQTADDSLSL--TSPNTESIFVEDPYTASLRSEI 71
Query: 820 SSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGM 879
SD EFEAESWSL VD ++ +Q+++V+KRQDV++ELMQTE+HH++TL IM +++ + +
Sbjct: 72 ESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRAL 131
Query: 880 KEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCA-GSDRNFVIDRIGDILVQQ 938
+EELQ + ++FPC D+LLE H HF +KERRQES GSDRN+VI +IGD+LVQQ
Sbjct: 132 QEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQ 191
Query: 939 FSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQNKKFQNFIKLRNSNLLARRRGIPECIL 997
FS EN +MK+ YG FC H EAV+ +K L QQNKKFQN IK + + RR G+ ECIL
Sbjct: 192 FSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECIL 251
Query: 998 LVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEI 1057
LVTQRITKYPVLVERI+Q T+ TE+++DL +AL LIKD+I+ VD KV+E EK Q+ EI
Sbjct: 252 LVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREI 311
Query: 1058 LNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFL 1117
K++ K+ +KLKNG FRK+ ++ +R L +G++ WKT +GR KDILA+LLTDVLL L
Sbjct: 312 AGKMDLKSSSKLKNGLTFRKEDML--QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLL 369
Query: 1118 QEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERN 1177
QEKDQKY+FA+VD KP VISLQKLI REVANEE+ MFLISAS GPEMYEI+T+SKE+RN
Sbjct: 370 QEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRN 429
Query: 1178 NWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKL 1237
WM IQ+AVESCP+E+ G S +E+++ EAR +++ QE L+ +DQ I L EK
Sbjct: 430 AWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQ 489
Query: 1238 HIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVS 1297
IY E+ E+ G ED+ L DP E Q +L +A+ E E +Q + Q+G+ +
Sbjct: 490 QIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI-CRQLGSAN 548
Query: 1298 QSCED---SCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQG-----VVTD 1349
ED S G A+T + +D SPT + G + S DP + D
Sbjct: 549 GQAEDGGSSTGPPRRAETFAGYDCTNSPTKN----GSFKKKVSSTDPRPRDWRGPPNSPD 604
Query: 1350 LAVSDAG------EKVECRNFPGSS---------QSEIIQAIQNLTRLLYSLQAALTIQD 1394
L +SD+ E + PG+ +SE++Q IQ L++LL +LQA + QD
Sbjct: 605 LKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQD 664
Query: 1395 SHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANVHQLQHQLQQEQRRW 1454
S++E R +Q++E S L+ ++ R+ ++Q EE A + +LQ QL+ EQ+RW
Sbjct: 665 SYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRW 724
Query: 1455 LRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEYQHSLERLREGQRLV 1514
R + Q + + LQERE E + E L + R EL+ Q Q YQH LERLRE QR V
Sbjct: 725 ERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAV 784
Query: 1515 EREQARMRAQQSLLGHWKHGRQRSLPAVLLP 1545
ERE+ R+ + L +Q + P L P
Sbjct: 785 ERERERLELLRRL------KKQNTAPGALPP 809
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 588 bits (1517), Expect = e-167
Identities = 390/1120 (34%), Positives = 610/1120 (54%), Gaps = 103/1120 (9%)
Query: 472 LKKRSSSLDALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNIS 531
+ +RS SL+ L + G G+ S + + + R + +DS + +E D
Sbjct: 1596 IHRRSFSLEGLTGGA-GVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESD 1654
Query: 532 RAESLPLSSNLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVC-----SSSEEQRA 586
+ E + + + + ++ + IS T+ + +T+ +S
Sbjct: 1655 QREHRMFDQQICHRS------KQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHST 1708
Query: 587 YSLSEPPRENRIQEEEWDKYI-IPAKSESE---KYKVSRTFSFLMNRMTSPR-------- 634
+ + I EE ++ P+K +SE KVSRTFS++ N+M+S +
Sbjct: 1709 FHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKE 1768
Query: 635 -NKSKTKSKDAKDKEK----LNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVH 689
+K K K KD+KDKEK +N H F+ G + C C K K++ C+NC+A VH
Sbjct: 1769 KDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH 1828
Query: 690 KGCKDAAPACTKKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGL----PTGR 745
KGC+++ +C K ++ P+ L H +SS+P + P+
Sbjct: 1829 KGCRESLASCAKVKMKQ------------------PKGSLQAHDTSSLPTVIMRNKPSQP 1870
Query: 746 RETVGQVHPLSRSVPGTTLESFRRSATSLE---------------SESDHNSCRSRSHSD 790
+E L T + + RRS S+ E+ N+ + SHS
Sbjct: 1871 KERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHST 1930
Query: 791 ELLQSMGS-SPSTESFIME----DVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEK 845
+ L + + STES E D+ + L D ++++ EAESWS ++D F +Q+K
Sbjct: 1931 DSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKK 1990
Query: 846 DVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHR 905
DV+KRQ+VI+ELMQTE HH++TL IMS ++ +GM +L + V+K+FPCLDEL+ IH
Sbjct: 1991 DVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHS 2050
Query: 906 HFFYSMKERRQESCAG-SDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNL 964
FF + ER++ES S++NF+I RIGD+LV QFS ENA ++KK YG+FC H ++VN
Sbjct: 2051 QFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNY 2110
Query: 965 FKELQ-QNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEE 1023
FK+L ++K+FQ F+K + S+ + RR GIPECILLVTQRITKYPVL +RILQ TK+ E
Sbjct: 2111 FKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVE 2170
Query: 1024 HKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSE 1083
+DL ++L L+KD+I VD KV YEK + EI K ++K+ ++K+G +F K+ L +
Sbjct: 2171 QEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDL--K 2228
Query: 1084 ERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIA 1143
+ L+ DG V+ K A GR K++ A+LLTD+L+FLQEKDQKYIFA++DQK +VISL+KLI
Sbjct: 2229 RKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIV 2288
Query: 1144 REVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESC-PEEKGGRTSESD 1202
REVA+EE+G+FLIS PEM E+H +SKEERN+W++ IQ + + +E G SE++
Sbjct: 2289 REVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENE 2348
Query: 1203 EDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELS-----GFEDVHLEPH 1257
E+K+ + R ++ +E L +DQ+I LEEK I+ ++ E S H P
Sbjct: 2349 EEKKMLDTRA---RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTH-SPR 2404
Query: 1258 LLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVL-------- 1309
+L + + E + L+ +A+ E E LQ V + G + + V+
Sbjct: 2405 VLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRR 2464
Query: 1310 ADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQ 1369
A+T D S + GG + G D ++ +D + G +S+
Sbjct: 2465 AETFGGFD---SHQMNASKGGEKEEG--DDGQDLRRTESDSGLKKGGNANLVFMLKRNSE 2519
Query: 1370 SEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPL-QDQKSR 1428
+++Q++ +L LL +LQ + QDS+IE +LVL ++ +L S+ R L + +K R
Sbjct: 2520 -QVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER---ALTRSLSRPSSLIEQEKQR 2575
Query: 1429 DADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLR 1488
++Q ++LAN+ + Q Q +E+RR R E ++R RE+ L +RE E Q ++ L +
Sbjct: 2576 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2635
Query: 1489 SRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLL 1528
R EL + YQ+ LERLR Q+ +EREQ ++R + L
Sbjct: 2636 EREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERL 2675
Score = 141 bits (356), Expect = 5e-33
Identities = 87/263 (33%), Positives = 133/263 (50%), Gaps = 4/263 (1%)
Query: 1 MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP 60
M+L+ +APLYG ++ + +D FY + GS RH ++ + L++ P
Sbjct: 1 MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
Query: 61 GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT 120
GH ETV V +C EG + +V + A A+ L T A A + L
Sbjct: 61 GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
Query: 121 PFALTAGALPALDEELVLALTHLELPLEWTVLGS-SSLEVSSHRESLLHLAMRWGLAKLS 179
+G + +LD++LVLA HL+LP EW VLG+ SL + RE+L+H A+R GL +L+
Sbjct: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
Query: 180 QFFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLS---E 236
F L PGG AL++ N+EGATP+ LAL G+ KL + +T S+S +
Sbjct: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
Query: 237 EASLHYIHSSETLTLTLNHTAEH 259
+ S+ + + TLT + H
Sbjct: 241 DCSVRHHRELDIYTLTSESDSHH 263
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 588 bits (1516), Expect = e-167
Identities = 400/1169 (34%), Positives = 624/1169 (53%), Gaps = 111/1169 (9%)
Query: 425 SVYPLSENVEGTAHTEAQQSFMSPSSS--CASNLNLSFGWHGFEKEQSHLKKRSSSLDAL 482
S+ P + G A + M+ S C S + S G + RS SL+ L
Sbjct: 1557 SLSPFRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGL------SADFNYRSFSLEGL 1610
Query: 483 DADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSSNL 542
+ G G+ S + + + R + +DS + +E D + E +
Sbjct: 1611 TGGA-GVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQI 1669
Query: 543 QSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVC-----SSSEEQRAYSLSEPPRENR 597
+ + + ++ + IS T+ + +T+ +S + +
Sbjct: 1670 CHRS------KQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTES 1723
Query: 598 IQEEEWDKYI-IPAKSESE---KYKVSRTFSFLMNRMTSPR---------NKSKTKSKDA 644
I EE ++ P+K +SE KVSRTFS++ N+M+S + +K K K KD+
Sbjct: 1724 ITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDS 1783
Query: 645 KDKEK----LNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACT 700
KDKEK +N H F+ G + C C K K++ C+NC+A VHKGC+++ +C
Sbjct: 1784 KDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCA 1843
Query: 701 KKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGL----PTGRRETVGQVHPLS 756
K ++ P+ L H +SS+P + P+ +E L
Sbjct: 1844 KVKMKQ------------------PKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLV 1885
Query: 757 RSVPGTTLESFRRSATSLE---------------SESDHNSCRSRSHSDELLQSMGS-SP 800
T + + RRS S+ E+ N+ + SHS + L + +
Sbjct: 1886 DETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNE 1945
Query: 801 STESFIME----DVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFE 856
STES E D+ + L D ++++ EAESWS ++D F +Q+KDV+KRQ+VI+E
Sbjct: 1946 STESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYE 2005
Query: 857 LMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQ 916
LMQTE HH++TL IMS ++ +GM +L + V+K+FPCLDEL+ IH FF + ER++
Sbjct: 2006 LMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKK 2065
Query: 917 ESCAG-SDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKF 974
ES S++NF+I RIGD+LV QFS ENA ++KK YG+FC H ++VN FK+L ++K+F
Sbjct: 2066 ESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRF 2125
Query: 975 QNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLI 1034
Q F+K + S+ + RR GIPECILLVTQRITKYPVL +RILQ TK+ E +DL ++L L+
Sbjct: 2126 QAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLV 2185
Query: 1035 KDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVY 1094
KD+I VD KV YEK + EI K ++K+ ++K+G +F K+ L + + L+ DG V+
Sbjct: 2186 KDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDL--KRKKLVRDGSVF 2243
Query: 1095 WKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMF 1154
K A GR K++ A+LLTD+L+FLQEKDQKYIFA++DQK +VISL+KLI REVA+EE+G+F
Sbjct: 2244 LKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLF 2303
Query: 1155 LISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESC-PEEKGGRTSESDEDKRKAEARVA 1213
LIS PEM E+H +SKEERN+W++ IQ + + +E G SE++E+K+ + R
Sbjct: 2304 LISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRA- 2362
Query: 1214 KIQQCQEILTNQDQQICAYLEEKLHIYAELGELS-----GFEDVHLEPHLLIKPDPGEPP 1268
++ +E L +DQ+I LEEK I+ ++ E S H P +L + + E
Sbjct: 2363 --RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTH-SPRVLFRSNTEEAL 2419
Query: 1269 QAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVL--------ADTLSSHDVPG 1320
+ L+ +A+ E E LQ V + G + + V+ A+T D
Sbjct: 2420 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFD--- 2476
Query: 1321 SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT 1380
S + GG + G D ++ +D + G +S+ +++Q++ +L
Sbjct: 2477 SHQMNASKGGEKEEG--DDGQDLRRTESDSGLKKGGNANLVFMLKRNSE-QVVQSVVHLY 2533
Query: 1381 RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPL-QDQKSRDADRQHEELAN 1439
LL +LQ + QDS+IE +LVL ++ +L S+ R L + +K R ++Q ++LAN
Sbjct: 2534 ELLSALQGVVLQQDSYIEDQKLVLSER---ALTRSLSRPSSLIEQEKQRSLEKQRQDLAN 2590
Query: 1440 VHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQE 1499
+ + Q Q +E+RR R E ++R RE+ L +RE E Q ++ L + R EL +
Sbjct: 2591 LQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGT 2650
Query: 1500 YQHSLERLREGQRLVEREQARMRAQQSLL 1528
YQ+ LERLR Q+ +EREQ ++R + L
Sbjct: 2651 YQYDLERLRAAQKQLEREQEQLRREAERL 2679
Score = 141 bits (356), Expect = 5e-33
Identities = 87/263 (33%), Positives = 133/263 (50%), Gaps = 4/263 (1%)
Query: 1 MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP 60
M+L+ +APLYG ++ + +D FY + GS RH ++ + L++ P
Sbjct: 1 MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
Query: 61 GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT 120
GH ETV V +C EG + +V + A A+ L T A A + L
Sbjct: 61 GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
Query: 121 PFALTAGALPALDEELVLALTHLELPLEWTVLGS-SSLEVSSHRESLLHLAMRWGLAKLS 179
+G + +LD++LVLA HL+LP EW VLG+ SL + RE+L+H A+R GL +L+
Sbjct: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
Query: 180 QFFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLS---E 236
F L PGG AL++ N+EGATP+ LAL G+ KL + +T S+S +
Sbjct: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
Query: 237 EASLHYIHSSETLTLTLNHTAEH 259
+ S+ + + TLT + H
Sbjct: 241 DCSVRHHRELDIYTLTSESDSHH 263
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 571 bits (1471), Expect = e-162
Identities = 354/940 (37%), Positives = 539/940 (57%), Gaps = 78/940 (8%)
Query: 634 RNKSKTKSKDAKDKEK----LNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVH 689
++K K K KD+KDKEK +N H F+ G + C C K K++ C+NC+A VH
Sbjct: 14 KDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH 73
Query: 690 KGCKDAAPACTKKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGL----PTGR 745
KGC+++ +C K ++ P+ L H +SS+P + P+
Sbjct: 74 KGCRESLASCAKVKMKQ------------------PKGSLQAHDTSSLPTVIMRNKPSQP 115
Query: 746 RETVGQVHPLSRSVPGTTLESFRRSATSLE---------------SESDHNSCRSRSHSD 790
+E L T + + RRS S+ E+ N+ + SHS
Sbjct: 116 KERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHST 175
Query: 791 ELLQSMGS-SPSTESFIME----DVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEK 845
+ L + + STES E D+ + L D ++++ EAESWS ++D F +Q+K
Sbjct: 176 DSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKK 235
Query: 846 DVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHR 905
DV+KRQ+VI+ELMQTE HH++TL IMS ++ +GM +L + V+K+FPCLDEL+ IH
Sbjct: 236 DVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHS 295
Query: 906 HFFYSMKERRQESCAG-SDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNL 964
FF + ER++ES S++NF+I RIGD+LV QFS ENA ++KK YG+FC H ++VN
Sbjct: 296 QFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNY 355
Query: 965 FKELQ-QNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEE 1023
FK+L ++K+FQ F+K + S+ + RR GIPECILLVTQRITKYPVL +RILQ TK+ E
Sbjct: 356 FKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVE 415
Query: 1024 HKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSE 1083
+DL ++L L+KD+I VD KV YEK + EI K ++K+ ++K+G +F K+ L +
Sbjct: 416 QEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDL--K 473
Query: 1084 ERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIA 1143
+ L+ DG V+ K A GR K++ A+LLTD+L+FLQEKDQKYIFA++DQK +VISL+KLI
Sbjct: 474 RKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIV 533
Query: 1144 REVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESC-PEEKGGRTSESD 1202
REVA+EE+G+FLIS PEM E+H +SKEERN+W++ IQ + + +E G SE++
Sbjct: 534 REVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENE 593
Query: 1203 EDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELS-----GFEDVHLEPH 1257
E+K+ + R ++ +E L +DQ+I LEEK I+ ++ E S H P
Sbjct: 594 EEKKMLDTRA---RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTH-SPR 649
Query: 1258 LLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVL-------- 1309
+L + + E + L+ +A+ E E LQ V + G + + V+
Sbjct: 650 VLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRR 709
Query: 1310 ADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQ 1369
A+T D S + GG + G D ++ +D + G +S+
Sbjct: 710 AETFGGFD---SHQMNASKGGEKEEG--DDGQDLRRTESDSGLKKGGNANLVFMLKRNSE 764
Query: 1370 SEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPL-QDQKSR 1428
+++Q++ +L LL +LQ + QDS+IE +LVL ++ +L S+ R L + +K R
Sbjct: 765 -QVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER---ALTRSLSRPSSLIEQEKQR 820
Query: 1429 DADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLR 1488
++Q ++LAN+ + Q Q +E+RR R E ++R RE+ L +RE E Q ++ L +
Sbjct: 821 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 880
Query: 1489 SRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLL 1528
R EL + YQ+ LERLR Q+ +EREQ ++R + L
Sbjct: 881 EREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERL 920
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 514 bits (1325), Expect = e-145
Identities = 334/890 (37%), Positives = 489/890 (54%), Gaps = 65/890 (7%)
Query: 628 NRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNAN 687
+R + + + K K K+AKD N H F + SG+ C C+K++ KE+L C CN
Sbjct: 15 SRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVT 74
Query: 688 VHKGCKDAAPACTK--KFQEKYNKNKPQTILGNSSFRDIP----QPGLSLHPSSSVPVGL 741
+H CKD CTK + Q+K K T L + S R +P +++PS S L
Sbjct: 75 IHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSL 134
Query: 742 PTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPS 801
RR L++SV T + A ES R S S + L + S
Sbjct: 135 LGSRRGRSSL--SLAKSVSTTNI------AGHFNDESPLGLRRILSQSTDSLNMRNRTLS 186
Query: 802 TESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTE 861
ES I E+V+ S L SD D ++F A+SWSL VD SF + +K+V+K+QDVI+EL+QTE
Sbjct: 187 VESLIDEEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTE 246
Query: 862 MHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQES-CA 920
+HH++TL IM+ +FR GM EEL L+ V +FPC+DEL +IH F + ERR+++ C
Sbjct: 247 LHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCP 306
Query: 921 GSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQNKKFQNFIK 979
GS RNFVI R+GD+L+ QFS +A +M K Y EFC H +A+ L+KEL ++K+FQ FI+
Sbjct: 307 GSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIR 366
Query: 980 LRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIA 1039
+ +R G+ ECILLVTQRITKYP+L+ RILQ++ EE +DL AL L+K++++
Sbjct: 367 KVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLS 426
Query: 1040 TVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTAT 1099
VD + + EK + EI N+++ + T + F ++ L+ R L++DG + WKTAT
Sbjct: 427 NVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELL--RRKLIHDGCLLWKTAT 484
Query: 1100 GRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISAS 1159
GRFKD+L LL+TDVL+FLQEKDQKYIF +D KPSV+SLQ LI R++AN+E+GMFLISA
Sbjct: 485 GRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLISA- 542
Query: 1160 SAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQ 1219
A PEMYE+HT S+++R+ W+R IQQ+V +CP + E++++ A +++ +
Sbjct: 543 -APPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDE--------AYLRRIK 593
Query: 1220 EILTNQDQQICAYLEEKLHIYAELGELSGFED------VHLEPHLLIKPDPGEPPQAASL 1273
L +D+ + L EK+ ++AE+ ED + P L + + E P+ L
Sbjct: 594 MELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERL 653
Query: 1274 LAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGREG 1333
L A++E E L+ + + + E + L G T+ VT E
Sbjct: 654 LQDAIREVEGLKDLLVGPGVELLLTPREPA---------LPLEPDSGGNTSPGVTANGEA 704
Query: 1334 RGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLTRLLYSLQAALTIQ 1393
R + + A SD+ ++ N S Q E +Q + NL LL+ LQAA+ Q
Sbjct: 705 RTFNG------SIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQ 758
Query: 1394 DSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDA------DRQHEELANVHQLQHQL 1447
D+ +E + EG + R + R ++Q ELA + Q QH L
Sbjct: 759 DTLME-----ARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELA-LLQRQHAL 812
Query: 1448 QQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQL 1497
QE+ LRRC + +AT L+ R RE + LL R E QL
Sbjct: 813 LQEE---LRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQL 859
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 510 bits (1313), Expect = e-144
Identities = 334/891 (37%), Positives = 489/891 (54%), Gaps = 66/891 (7%)
Query: 628 NRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNAN 687
+R + + + K K K+AKD N H F + SG+ C C+K++ KE+L C CN
Sbjct: 15 SRELASKTREKEKMKEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVT 74
Query: 688 VHKGCKDAAPACTK--KFQEKYNKNKPQTILGNSSFRDIP----QPGLSLHPSSSVPVGL 741
+H CKD CTK + Q+K K T L + S R +P +++PS S L
Sbjct: 75 IHNRCKDTLANCTKVKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSL 134
Query: 742 PTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPS 801
RR L++SV T + A ES R S S + L + S
Sbjct: 135 LGSRRGRSSL--SLAKSVSTTNI------AGHFNDESPLGLRRILSQSTDSLNMRNRTLS 186
Query: 802 TESFIME-DVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQT 860
ES I E +V+ S L SD D ++F A+SWSL VD SF + +K+V+K+QDVI+EL+QT
Sbjct: 187 VESLIDEAEVIYSELMSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQT 246
Query: 861 EMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQES-C 919
E+HH++TL IM+ +FR GM EEL L+ V +FPC+DEL +IH F + ERR+++ C
Sbjct: 247 ELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALC 306
Query: 920 AGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQNKKFQNFI 978
GS RNFVI R+GD+L+ QFS +A +M K Y EFC H +A+ L+KEL ++K+FQ FI
Sbjct: 307 PGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFI 366
Query: 979 KLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMI 1038
+ + +R G+ ECILLVTQRITKYP+L+ RILQ++ EE +DL AL L+K+++
Sbjct: 367 RKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELL 426
Query: 1039 ATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTA 1098
+ VD + + EK + EI N+++ + T + F ++ L+ R L++DG + WKTA
Sbjct: 427 SNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGREELL--RRKLIHDGCLLWKTA 484
Query: 1099 TGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISA 1158
TGRFKD+L LL+TDVL+FLQEKDQKYIF +D KPSV+SLQ LI R++AN+E+GMFLISA
Sbjct: 485 TGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLISA 543
Query: 1159 SSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQC 1218
A PEMYE+HT S+++R+ W+R IQQ+V +CP + E++++ A +++
Sbjct: 544 --APPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPLIETEDE--------AYLRRI 593
Query: 1219 QEILTNQDQQICAYLEEKLHIYAELGELSGFED------VHLEPHLLIKPDPGEPPQAAS 1272
+ L +D+ + L EK+ ++AE+ ED + P L + + E P+
Sbjct: 594 KMELQQKDRALVELLREKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGER 653
Query: 1273 LLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGRE 1332
LL A++E E L+ + + + E + L G T+ VT E
Sbjct: 654 LLQDAIREVEGLKDLLVGPGVELLLTPREPA---------LPLEPDSGGNTSPGVTANGE 704
Query: 1333 GRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLTRLLYSLQAALTI 1392
R + + A SD+ ++ N S Q E +Q + NL LL+ LQAA+
Sbjct: 705 ARTFNG------SIELCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQ 758
Query: 1393 QDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDA------DRQHEELANVHQLQHQ 1446
QD+ +E + EG + R + R ++Q ELA + Q QH
Sbjct: 759 QDTLME-----ARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELA-LLQRQHA 812
Query: 1447 LQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQL 1497
L QE+ LRRC + +AT L+ R RE + LL R E QL
Sbjct: 813 LLQEE---LRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEARRQL 860
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 509 bits (1310), Expect = e-143
Identities = 331/876 (37%), Positives = 482/876 (55%), Gaps = 65/876 (7%)
Query: 642 KDAKDKEKLNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTK 701
K+AKD N H F + SG+ C C+K++ KE+L C CN +H CKD CTK
Sbjct: 2 KEAKDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTK 61
Query: 702 --KFQEKYNKNKPQTILGNSSFRDIP----QPGLSLHPSSSVPVGLPTGRRETVGQVHPL 755
+ Q+K K T L + S R +P +++PS S L RR L
Sbjct: 62 VKQKQQKAALLKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSL--SL 119
Query: 756 SRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSL 815
++SV T + A ES R S S + L + S ES I E+V+ S L
Sbjct: 120 AKSVSTTNI------AGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSEL 173
Query: 816 WSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIF 875
SD D ++F A+SWSL VD SF + +K+V+K+QDVI+EL+QTE+HH++TL IM+ +F
Sbjct: 174 MSDFEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLF 233
Query: 876 RKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQES-CAGSDRNFVIDRIGDI 934
R GM EEL L+ V +FPC+DEL +IH F + ERR+++ C GS RNFVI R+GD+
Sbjct: 234 RTGMLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDL 293
Query: 935 LVQQFSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQNKKFQNFIKLRNSNLLARRRGIP 993
L+ QFS +A +M K Y EFC H +A+ L+KEL ++K+FQ FI+ + +R G+
Sbjct: 294 LISQFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQ 353
Query: 994 ECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQK 1053
ECILLVTQRITKYP+L+ RILQ++ EE +DL AL L+K++++ VD + + EK +
Sbjct: 354 ECILLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGAR 413
Query: 1054 WLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKDILALLLTDV 1113
EI N+++ + T + F ++ L+ R L++DG + WKTATGRFKD+L LL+TDV
Sbjct: 414 LQEIYNRMDPRAQTPVPGKGPFGREELL--RRKLIHDGCLLWKTATGRFKDVLVLLMTDV 471
Query: 1114 LLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSK 1173
L+FLQEKDQKYIF +D KPSV+SLQ LI R++AN+E+GMFLISA A PEMYE+HT S+
Sbjct: 472 LVFLQEKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLISA--APPEMYEVHTASR 528
Query: 1174 EERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVAKIQQCQEILTNQDQQICAYL 1233
++R+ W+R IQQ+V +CP + E++++ A +++ + L +D+ + L
Sbjct: 529 DDRSTWIRVIQQSVRTCPSREDFPLIETEDE--------AYLRRIKMELQQKDRALVELL 580
Query: 1234 EEKLHIYAELGELSGFED------VHLEPHLLIKPDPGEPPQAASLLAAALKEAESLQVA 1287
EK+ ++AE+ ED + P L + + E P+ LL A++E E L+
Sbjct: 581 REKVGLFAEMTHFQAEEDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDL 640
Query: 1288 VKASQMGAVSQSCEDSCGDSVLADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVV 1347
+ + + E + L G T+ VT E R + +
Sbjct: 641 LVGPGVELLLTPREPA---------LPLEPDSGGNTSPGVTANGEARTFNG------SIE 685
Query: 1348 TDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQ 1407
A SD+ ++ N S Q E +Q + NL LL+ LQAA+ QD+ +E +
Sbjct: 686 LCRADSDSSQRDRNGNQLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLME-----ARFP 740
Query: 1408 EGLSLGHSILRGGPLQDQKSRDA------DRQHEELANVHQLQHQLQQEQRRWLRRCEQQ 1461
EG + R + R ++Q ELA + Q QH L QE+ LRRC +
Sbjct: 741 EGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELA-LLQRQHALLQEE---LRRCRRL 796
Query: 1462 QRAQATRESWLQERERECQSQEELLLRSRGELDLQL 1497
+AT L+ R RE + LL R E QL
Sbjct: 797 GEERATEAGSLEARLRESEQARALLEREAEEARRQL 832
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 169 bits (427), Expect = 3e-41
Identities = 132/524 (25%), Positives = 247/524 (47%), Gaps = 57/524 (10%)
Query: 718 NSSFRDIPQPGLSLHPSSSVPVGL----------PTGRRETVGQVHPLSRSVPGTTLESF 767
N+ D P+PG + S P L GR E++ + RS E+
Sbjct: 614 NNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRS---RKAENV 670
Query: 768 RRSATSLESESDHNSCRSRSHSDELLQSMGS--------------------SPSTESFIM 807
RS + ++ ++ + R + S+ + SPS F
Sbjct: 671 PRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSL-GFCT 729
Query: 808 EDVVDSSLWSDLS--SDAQ-EFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHH 864
+ ++ L DL SD + E +A++W V + I RQ+VI EL TE H
Sbjct: 730 DTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASH 789
Query: 865 IQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDR 924
++TL ++ IF + MK+E + + ++FP L EL+EIH + +MK+ R+E
Sbjct: 790 LRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP----- 844
Query: 925 NFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNK-KFQNFIKLRNS 983
+I I D+++ +F +++++ +FC + A+ L K Q+ + +FQ F++ S
Sbjct: 845 --IIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAES 902
Query: 984 NLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDL 1043
+ RR + + I+ QR+TKYP+L+E I+++T+ T EH+ L +A ++++ V+
Sbjct: 903 HPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNE 962
Query: 1044 KVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFK 1103
V + E + +++ + N ++L R ++++G + W+ + +
Sbjct: 963 AVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTL 1022
Query: 1104 DILALLLTDVLLFLQEKDQKYIF-----AAVDQKPS------VISLQKLIAREVANEERG 1152
D+ LLL D+L+ LQ++D+K + AV S V+ L ++ R VA ++R
Sbjct: 1023 DLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA 1082
Query: 1153 MFLISASSAG-PEMYEIHTNSKEERNNWMRRIQQAVESCPEEKG 1195
F+I S G P++YE+ + ++N WM +++AV + G
Sbjct: 1083 FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPG 1126
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 169 bits (427), Expect = 3e-41
Identities = 132/524 (25%), Positives = 247/524 (47%), Gaps = 57/524 (10%)
Query: 718 NSSFRDIPQPGLSLHPSSSVPVGL----------PTGRRETVGQVHPLSRSVPGTTLESF 767
N+ D P+PG + S P L GR E++ + RS E+
Sbjct: 574 NNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKRS---RKAENV 630
Query: 768 RRSATSLESESDHNSCRSRSHSDELLQSMGS--------------------SPSTESFIM 807
RS + ++ ++ + R + S+ + SPS F
Sbjct: 631 PRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIESPSL-GFCT 689
Query: 808 EDVVDSSLWSDLS--SDAQ-EFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHH 864
+ ++ L DL SD + E +A++W V + I RQ+VI EL TE H
Sbjct: 690 DTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASH 749
Query: 865 IQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDR 924
++TL ++ IF + MK+E + + ++FP L EL+EIH + +MK+ R+E
Sbjct: 750 LRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMKKLREEGP----- 804
Query: 925 NFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNK-KFQNFIKLRNS 983
+I I D+++ +F +++++ +FC + A+ L K Q+ + +FQ F++ S
Sbjct: 805 --IIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAES 862
Query: 984 NLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDL 1043
+ RR + + I+ QR+TKYP+L+E I+++T+ T EH+ L +A ++++ V+
Sbjct: 863 HPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNE 922
Query: 1044 KVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFK 1103
V + E + +++ + N ++L R ++++G + W+ + +
Sbjct: 923 AVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTL 982
Query: 1104 DILALLLTDVLLFLQEKDQKYIF-----AAVDQKPS------VISLQKLIAREVANEERG 1152
D+ LLL D+L+ LQ++D+K + AV S V+ L ++ R VA ++R
Sbjct: 983 DLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRA 1042
Query: 1153 MFLISASSAG-PEMYEIHTNSKEERNNWMRRIQQAVESCPEEKG 1195
F+I S G P++YE+ + ++N WM +++AV + G
Sbjct: 1043 FFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPG 1086
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 167 bits (424), Expect = 6e-41
Identities = 132/494 (26%), Positives = 235/494 (47%), Gaps = 44/494 (8%)
Query: 812 DSSLWSDLSSDAQEFEAE------SWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHI 865
DS + + S+ ++FE + +W +V + IKRQ+VI EL TE H+
Sbjct: 744 DSVAFGESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHV 803
Query: 866 QTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRN 925
+TL ++ ++F + + E L S + KIF L+++L++H MK R+ +
Sbjct: 804 RTLKVLDQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKR-----NET 858
Query: 926 FVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKFQNFIKLRNSN 984
VID+IG+ L+ FS K+K FC + A+ + K Q ++ +FQ F++ SN
Sbjct: 859 SVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESN 918
Query: 985 LLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLK 1044
L RR + + I QR+TKYP+L++ I +YT+ TE K ++KA + ++ V+
Sbjct: 919 PLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTEREK-VKKAADHCRQILNYVNQA 977
Query: 1045 VNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGRFKD 1104
V E E Q+ + +++ + + +V + L +R ++++G + WK + D
Sbjct: 978 VKEAENKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTID 1037
Query: 1105 ILALLLTDVLLFLQEKD--------QKYIFAAVDQKPS---VISLQKLIAREVANEERGM 1153
+ LLL D+L+ LQ++D K + + D K + VI L ++ R+VA + + +
Sbjct: 1038 LYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKAL 1097
Query: 1154 FLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEARVA 1213
F+IS S G ++YE+ + E+ W I + S E+ +
Sbjct: 1098 FVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQ---------------STKPI 1142
Query: 1214 KIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQAASL 1273
+ Q + D++ + L+E+ H + G S D+ LE L+ PQ+ SL
Sbjct: 1143 PLPQSTPGEGDNDEEDPSKLKEEQHGISVTGLQSPDRDLGLESTLI-----SSKPQSHSL 1197
Query: 1274 LAAALKEAESLQVA 1287
+ E L VA
Sbjct: 1198 STSGKSEVRDLFVA 1211
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
sapiens]
Length = 927
Score = 150 bits (380), Expect = 8e-36
Identities = 130/522 (24%), Positives = 231/522 (44%), Gaps = 47/522 (9%)
Query: 697 PACTKKFQE------KYNKNKPQTILGNSSFR------DIPQPGLSLHPSSSVPVGLPTG 744
PA TKK ++N+ +PQ FR D +PG + VG+P+
Sbjct: 273 PAKTKKGLSSILDAARWNRGEPQV----PDFRHLKAEVDAEKPGATDRKGG---VGMPSR 325
Query: 745 RRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH--NSCRSRSHSDELLQSMGSSPST 802
R + + PG +L + E +D S L+S+ ST
Sbjct: 326 DRN----IGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPEST 381
Query: 803 ESFIMEDVVDSSLWSDLSSDAQEFEAES---WSLVVDPSFCNRQEKDVIKRQDVIFELMQ 859
+ + + + E E E W +V P + K +KRQ+VI EL+
Sbjct: 382 DEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLV 441
Query: 860 TEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESC 919
TE H++ L ++ ++F + M E L + IFP LDEL+E+H F + +RRQES
Sbjct: 442 TEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES- 500
Query: 920 AGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKFQNFI 978
++I+ IGD+L+ +F S +KI FC A+ K Q ++ +F F+
Sbjct: 501 -----GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 555
Query: 979 KLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMI 1038
+ S RR + + I QR+TKYP+L++ I Q T+E TE K A C ++++
Sbjct: 556 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAEC-CREIL 614
Query: 1039 ATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTA 1098
V+ V + E + + +++ + + + + L ++ L+++G + W+
Sbjct: 615 HHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVT 674
Query: 1099 TGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPS-----------VISLQKLIAREVA 1147
+ ++ LLL D+LL LQ +D++ + + + + V+ L + REVA
Sbjct: 675 KDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVA 734
Query: 1148 NEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVES 1189
+ + +++ ++YE+ + ER NW I + S
Sbjct: 735 TDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGS 776
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
sapiens]
Length = 879
Score = 150 bits (380), Expect = 8e-36
Identities = 130/522 (24%), Positives = 231/522 (44%), Gaps = 47/522 (9%)
Query: 697 PACTKKFQE------KYNKNKPQTILGNSSFR------DIPQPGLSLHPSSSVPVGLPTG 744
PA TKK ++N+ +PQ FR D +PG + VG+P+
Sbjct: 225 PAKTKKGLSSILDAARWNRGEPQV----PDFRHLKAEVDAEKPGATDRKGG---VGMPSR 277
Query: 745 RRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH--NSCRSRSHSDELLQSMGSSPST 802
R + + PG +L + E +D S L+S+ ST
Sbjct: 278 DRN----IGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPEST 333
Query: 803 ESFIMEDVVDSSLWSDLSSDAQEFEAES---WSLVVDPSFCNRQEKDVIKRQDVIFELMQ 859
+ + + + E E E W +V P + K +KRQ+VI EL+
Sbjct: 334 DEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLV 393
Query: 860 TEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESC 919
TE H++ L ++ ++F + M E L + IFP LDEL+E+H F + +RRQES
Sbjct: 394 TEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES- 452
Query: 920 AGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKFQNFI 978
++I+ IGD+L+ +F S +KI FC A+ K Q ++ +F F+
Sbjct: 453 -----GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 507
Query: 979 KLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMI 1038
+ S RR + + I QR+TKYP+L++ I Q T+E TE K A C ++++
Sbjct: 508 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAEC-CREIL 566
Query: 1039 ATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTA 1098
V+ V + E + + +++ + + + + L ++ L+++G + W+
Sbjct: 567 HHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVT 626
Query: 1099 TGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPS-----------VISLQKLIAREVA 1147
+ ++ LLL D+LL LQ +D++ + + + + V+ L + REVA
Sbjct: 627 KDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVA 686
Query: 1148 NEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVES 1189
+ + +++ ++YE+ + ER NW I + S
Sbjct: 687 TDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGS 728
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
sapiens]
Length = 912
Score = 150 bits (380), Expect = 8e-36
Identities = 130/522 (24%), Positives = 231/522 (44%), Gaps = 47/522 (9%)
Query: 697 PACTKKFQE------KYNKNKPQTILGNSSFR------DIPQPGLSLHPSSSVPVGLPTG 744
PA TKK ++N+ +PQ FR D +PG + VG+P+
Sbjct: 258 PAKTKKGLSSILDAARWNRGEPQV----PDFRHLKAEVDAEKPGATDRKGG---VGMPSR 310
Query: 745 RRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH--NSCRSRSHSDELLQSMGSSPST 802
R + + PG +L + E +D S L+S+ ST
Sbjct: 311 DRN----IGAPGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGPMSLESLAPPEST 366
Query: 803 ESFIMEDVVDSSLWSDLSSDAQEFEAES---WSLVVDPSFCNRQEKDVIKRQDVIFELMQ 859
+ + + + E E E W +V P + K +KRQ+VI EL+
Sbjct: 367 DEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLV 426
Query: 860 TEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESC 919
TE H++ L ++ ++F + M E L + IFP LDEL+E+H F + +RRQES
Sbjct: 427 TEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES- 485
Query: 920 AGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQ-QNKKFQNFI 978
++I+ IGD+L+ +F S +KI FC A+ K Q ++ +F F+
Sbjct: 486 -----GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFV 540
Query: 979 KLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMI 1038
+ S RR + + I QR+TKYP+L++ I Q T+E TE K A C ++++
Sbjct: 541 QEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTEREKVELAAEC-CREIL 599
Query: 1039 ATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTA 1098
V+ V + E + + +++ + + + + L ++ L+++G + W+
Sbjct: 600 HHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVT 659
Query: 1099 TGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPS-----------VISLQKLIAREVA 1147
+ ++ LLL D+LL LQ +D++ + + + + V+ L + REVA
Sbjct: 660 KDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVA 719
Query: 1148 NEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVES 1189
+ + +++ ++YE+ + ER NW I + S
Sbjct: 720 TDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGS 761
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 88.2 bits (217), Expect = 6e-17
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 38/357 (10%)
Query: 849 KRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFF 908
KRQ I EL+QTE ++ L ++ E+F+K M E L + IF EL+ +
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241
Query: 909 YSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFC-CHHKEAVNLFKE 967
+++ R++ G ++ + IGDIL + S A Y FC C A L ++
Sbjct: 1242 KALRVRKK---TGGEK-MPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQK 1291
Query: 968 LQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDL 1027
++ F+ F+K S+ + + +L QRIT+YP+L+ IL+ T E +H L
Sbjct: 1292 TDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSL 1351
Query: 1028 RKALCLIKDMIATVDLKVNEYEKNQK--WLEILNKIENKTYTKLKNGHVFRKQALMSEER 1085
+ AL +++ + V+ V E E + + W++ + E L +F R
Sbjct: 1352 KLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEG-----LAEQLIFNSLTNCLGPR 1406
Query: 1086 TLLYDGLVYWKTATGRFKDILALLLTDVLL-------FLQEKDQKYIFAAVDQKPSVISL 1138
LL+ G +Y KT + K++ L D LL F + +F++ +
Sbjct: 1407 KLLHSGKLY-KTKSN--KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYK 1463
Query: 1139 QKLIAREV-------ANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVE 1188
+ EV + + +F IS +Y + T++ ER W+++I+ A E
Sbjct: 1464 TPIFLNEVLVKLPTDPSSDEPVFHISHID---RVYTLRTDNINERTAWVQKIKAASE 1517
Score = 43.9 bits (102), Expect = 0.001
Identities = 39/142 (27%), Positives = 71/142 (50%), Gaps = 16/142 (11%)
Query: 1423 QDQKSRDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQ 1482
+D++ + +R + EL + Q ++Q+QR E +++AQ +E W + ++RE Q Q
Sbjct: 364 EDKRKANYERGNMELEK--RRQALMEQQQR------EAERKAQKEKEEW-ERKQRELQEQ 414
Query: 1483 EELLLRSRGELDLQLQEYQHSLERLREGQR---LVEREQARMRAQQSLLGHWKHGRQRSL 1539
E + + EL+ +L E Q LER RE +R + RE A+ ++ W+ R++ L
Sbjct: 415 E---WKKQLELEKRL-EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
Query: 1540 PAVLLPGGPEVMELNRSESLCH 1561
E++ LN + H
Sbjct: 471 LNQKNREQEEIVRLNSKKKNLH 492
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 88.2 bits (217), Expect = 6e-17
Identities = 90/357 (25%), Positives = 158/357 (44%), Gaps = 38/357 (10%)
Query: 849 KRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFF 908
KRQ I EL+QTE ++ L ++ E+F+K M E L + IF EL+ +
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268
Query: 909 YSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFC-CHHKEAVNLFKE 967
+++ R++ G ++ + IGDIL + S A Y FC C A L ++
Sbjct: 1269 KALRVRKK---TGGEK-MPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQK 1318
Query: 968 LQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDL 1027
++ F+ F+K S+ + + +L QRIT+YP+L+ IL+ T E +H L
Sbjct: 1319 TDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSL 1378
Query: 1028 RKALCLIKDMIATVDLKVNEYEKNQK--WLEILNKIENKTYTKLKNGHVFRKQALMSEER 1085
+ AL +++ + V+ V E E + + W++ + E L +F R
Sbjct: 1379 KLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEG-----LAEQLIFNSLTNCLGPR 1433
Query: 1086 TLLYDGLVYWKTATGRFKDILALLLTDVLL-------FLQEKDQKYIFAAVDQKPSVISL 1138
LL+ G +Y KT + K++ L D LL F + +F++ +
Sbjct: 1434 KLLHSGKLY-KTKSN--KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYK 1490
Query: 1139 QKLIAREV-------ANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVE 1188
+ EV + + +F IS +Y + T++ ER W+++I+ A E
Sbjct: 1491 TPIFLNEVLVKLPTDPSSDEPVFHISHID---RVYTLRTDNINERTAWVQKIKAASE 1544
Score = 43.9 bits (102), Expect = 0.001
Identities = 39/142 (27%), Positives = 71/142 (50%), Gaps = 16/142 (11%)
Query: 1423 QDQKSRDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQ 1482
+D++ + +R + EL + Q ++Q+QR E +++AQ +E W + ++RE Q Q
Sbjct: 364 EDKRKANYERGNMELEK--RRQALMEQQQR------EAERKAQKEKEEW-ERKQRELQEQ 414
Query: 1483 EELLLRSRGELDLQLQEYQHSLERLREGQR---LVEREQARMRAQQSLLGHWKHGRQRSL 1539
E + + EL+ +L E Q LER RE +R + RE A+ ++ W+ R++ L
Sbjct: 415 E---WKKQLELEKRL-EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQEL 470
Query: 1540 PAVLLPGGPEVMELNRSESLCH 1561
E++ LN + H
Sbjct: 471 LNQKNREQEEIVRLNSKKKNLH 492
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 78.6 bits (192), Expect = 5e-14
Identities = 83/350 (23%), Positives = 142/350 (40%), Gaps = 25/350 (7%)
Query: 849 KRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFF 908
KRQ I EL+ TE +++ L +++EIF+K + E L V IF EL+ +
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 909 YSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKE- 967
+++ R++ S + IGDIL Q Y FC L ++
Sbjct: 1297 KALRVRKKMS----GEKMPVKMIGDILSAQLPHMQP------YIRFCSRQLNGAALIQQK 1346
Query: 968 LQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDL 1027
+ F+ F+K + + + IL QR+T+YP++++ IL+ T E +H L
Sbjct: 1347 TDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHL 1406
Query: 1028 RKALCLIKDMIATVDLKVNEYEKNQK--WLEILNKIENKTYTKLKNGHVFRKQALMSEER 1085
+ AL +++ + V+ V E E + + W++ + E L VF R
Sbjct: 1407 KHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEG-----LSEQLVFNSVTNCLGPR 1461
Query: 1086 TLLYDGLVYWKTATGRFKDIL---ALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLI 1142
L+ G +Y + L LLLT + L +F+ + +
Sbjct: 1462 KFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIF 1521
Query: 1143 AREV----ANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVE 1188
EV + G I S +Y + S ER W+++I+ A E
Sbjct: 1522 LNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASE 1571
Score = 41.2 bits (95), Expect = 0.008
Identities = 36/118 (30%), Positives = 60/118 (50%), Gaps = 12/118 (10%)
Query: 1423 QDQKSRDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATR-ESWLQERERECQS 1481
+D+K + +R + EL Q L ++QR+ R Q +RA+ R E QE+ER+ Q
Sbjct: 351 EDKKRENFERGNLELEKRRQA---LLEQQRKEQERLAQLERAEQERKERERQEQERKRQL 407
Query: 1482 QEELLLRSRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSL 1539
+ E L + EL+ Q +E ER +E +R RE A+ ++ W+ R++ L
Sbjct: 408 ELEKQLEKQRELERQREE-----ERRKEIER---REAAKRELERQRQLEWERNRRQEL 457
Score = 38.5 bits (88), Expect = 0.054
Identities = 33/136 (24%), Positives = 62/136 (45%), Gaps = 6/136 (4%)
Query: 1424 DQKSRDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQE 1483
+Q+ ++ +RQ +E QL+ + Q E++R L R +++R + +RE E Q Q
Sbjct: 390 EQERKERERQEQE--RKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQL 447
Query: 1484 ELLLRSRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVL 1543
E R EL Q + Q + L+ ++ +E E + ++ H G+ + + L
Sbjct: 448 EWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKK----HQLEGKLQDIRCRL 503
Query: 1544 LPGGPEVMELNRSESL 1559
E+ N+S L
Sbjct: 504 TTQRQEIESTNKSREL 519
Score = 36.2 bits (82), Expect = 0.27
Identities = 31/95 (32%), Positives = 46/95 (48%), Gaps = 14/95 (14%)
Query: 1422 LQDQKSRDADR--QHEELANVHQLQHQLQQEQRR-------WLRRCEQQQRAQATRESWL 1472
LQ QKS +A+R Q E+ + +L+ Q ++ QRR WL +Q+ Q R+
Sbjct: 619 LQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKL-- 676
Query: 1473 QERERECQSQEELLLRSRGELDLQLQEYQHSLERL 1507
E E +EE + + GE + QE Q L RL
Sbjct: 677 --HEEEKLKREESVKKKDGE-EKGKQEAQDKLGRL 708
>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
sapiens]
Length = 2063
Score = 77.8 bits (190), Expect = 8e-14
Identities = 68/279 (24%), Positives = 133/279 (47%), Gaps = 24/279 (8%)
Query: 840 CNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKE---ELQLDHSTVDKIFPC 896
C++ + D+ R+ V L+ TE ++++L + + + + +K+ + D S VD+IF
Sbjct: 1059 CSKPQVDM--RKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQ 1116
Query: 897 LDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCC 956
+ ELLE H F ++ Q A ++G +LVQ FS++ + Y +
Sbjct: 1117 IPELLEHHEQFLEQVRHCMQTWHAQ-------QKVGALLVQSFSKDVLVNIYSAYIDNFL 1169
Query: 957 HHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQY 1016
+ K+AV + KE + F F++ ++ ++ + + ++ QRI +Y +LV+ +L++
Sbjct: 1170 NAKDAVRVAKEAR--PAFLKFLE-QSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKH 1226
Query: 1017 TKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFR 1076
T E +H L +A IK + ++ V E+ ++ +L +IE H+
Sbjct: 1227 TPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIE---------AHIEG 1277
Query: 1077 KQALMSEERTLLYDGLVYWKTATGRFKDILALLLTDVLL 1115
+ L + R L +V A G KD L TD+++
Sbjct: 1278 MEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIV 1316
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 76.6 bits (187), Expect = 2e-13
Identities = 72/315 (22%), Positives = 142/315 (45%), Gaps = 34/315 (10%)
Query: 736 SVPVGLPTGRR-ETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQ 794
S+ + P+ +R + + +V L+ +P +R + +L+ S RS S D L
Sbjct: 60 SLDISEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSI---SFRSESRPDILAP 116
Query: 795 SMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVI 854
S + S DS LWS E++ + V+ +++ IKRQ+ I
Sbjct: 117 RPWSRNAAPSSTKRR--DSKLWS-----------ETFDVCVNQMLTSKE----IKRQEAI 159
Query: 855 FELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKER 914
FEL Q E I+ L + + + M + + +++IF LD L+ +H +++
Sbjct: 160 FELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDV 219
Query: 915 RQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKF 974
R+ GS + +G ILV ++ Y +C + A L +Q+ +
Sbjct: 220 RKPD--GST-----EHVGPILVGWLPCLSS------YDSYCSNQVAAKALLDHKKQDHRV 266
Query: 975 QNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLI 1034
Q+F++ + +R+ + + + R+ KYP+L+ IL++T + + L +A+ +I
Sbjct: 267 QDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINII 326
Query: 1035 KDMIATVDLKVNEYE 1049
+ ++A ++ K E E
Sbjct: 327 QGIVAEINTKTGESE 341
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 75.1 bits (183), Expect = 5e-13
Identities = 71/309 (22%), Positives = 139/309 (44%), Gaps = 34/309 (11%)
Query: 742 PTGRR-ETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSP 800
P+ +R + + +V L+ +P +R + +L+ S RS S D L S
Sbjct: 40 PSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSI---SFRSESRPDILAPRPWSRN 96
Query: 801 STESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQT 860
+ S DS LWS E++ + V+ +++ IKRQ+ IFEL Q
Sbjct: 97 AAPSSTKRR--DSKLWS-----------ETFDVCVNQMLTSKE----IKRQEAIFELSQG 139
Query: 861 EMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCA 920
E I+ L + + + M + + +++IF LD L+ +H +++ R+
Sbjct: 140 EEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPD-- 197
Query: 921 GSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKL 980
GS + +G ILV ++ Y +C + A L +Q+ + Q+F++
Sbjct: 198 GST-----EHVGPILVGWLPCLSS------YDSYCSNQVAAKALLDHKKQDHRVQDFLQR 246
Query: 981 RNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIAT 1040
+ +R+ + + + R+ KYP+L+ IL++T + + L +A+ +I+ ++A
Sbjct: 247 CLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAE 306
Query: 1041 VDLKVNEYE 1049
++ K E E
Sbjct: 307 INTKTGESE 315
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 75.1 bits (183), Expect = 5e-13
Identities = 71/309 (22%), Positives = 139/309 (44%), Gaps = 34/309 (11%)
Query: 742 PTGRR-ETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDELLQSMGSSP 800
P+ +R + + +V L+ +P +R + +L+ S RS S D L S
Sbjct: 34 PSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSI---SFRSESRPDILAPRPWSRN 90
Query: 801 STESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQT 860
+ S DS LWS E++ + V+ +++ IKRQ+ IFEL Q
Sbjct: 91 AAPSSTKRR--DSKLWS-----------ETFDVCVNQMLTSKE----IKRQEAIFELSQG 133
Query: 861 EMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCA 920
E I+ L + + + M + + +++IF LD L+ +H +++ R+
Sbjct: 134 EEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPD-- 191
Query: 921 GSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKL 980
GS + +G ILV ++ Y +C + A L +Q+ + Q+F++
Sbjct: 192 GST-----EHVGPILVGWLPCLSS------YDSYCSNQVAAKALLDHKKQDHRVQDFLQR 240
Query: 981 RNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIAT 1040
+ +R+ + + + R+ KYP+L+ IL++T + + L +A+ +I+ ++A
Sbjct: 241 CLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAE 300
Query: 1041 VDLKVNEYE 1049
++ K E E
Sbjct: 301 INTKTGESE 309
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 70.9 bits (172), Expect = 1e-11
Identities = 64/292 (21%), Positives = 130/292 (44%), Gaps = 11/292 (3%)
Query: 764 LESFRRS-ATSLESESDHNSCRSRSHSDELLQSMGSSPSTE-SFIMEDVVDSSLWSDLSS 821
L++F+++ A + D + RS +D L + E +F + + + S S
Sbjct: 1012 LDNFKKNTANDFSNVPDITTGLKRSQTDGTLDQVSHREKMEQTFRSAEQITALCRSFNDS 1071
Query: 822 DAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKE 881
A E + P R D + + VI EL+ TE +++ L + E++ + ++
Sbjct: 1072 QANGMEGPRENQDPPPRPLARHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQN 1131
Query: 882 ELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSE 941
E L ++ +F L E+LE + F ++++ A SD N ++ FS
Sbjct: 1132 ETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGIS---ASSDFN-TLETPSQFRKLLFSL 1187
Query: 942 ENA----SKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECIL 997
+ + K+Y FC +H + + + + +K F+ F+ RN + ++
Sbjct: 1188 GGSFLYYADHFKLYSGFCANHIKVQKVLERAKTDKAFKAFLDARNPTK-QHSSTLESYLI 1246
Query: 998 LVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYE 1049
QR+ KYP+L++ ++ T + +EEH L +AL ++ + + ++ YE
Sbjct: 1247 KPVQRVLKYPLLLKELVSLTDQESEEHYHLTEALKAMEKVASHINEMQKIYE 1298
>gi|83715966 hypothetical protein LOC389337 [Homo sapiens]
Length = 675
Score = 68.9 bits (167), Expect = 4e-11
Identities = 47/225 (20%), Positives = 116/225 (51%), Gaps = 20/225 (8%)
Query: 843 QEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLE 902
+++ ++ ++ + EL+ TE+ ++ L + + R ++ QL +D +F +D++++
Sbjct: 24 EDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQ---QLPQGDLDVLFSNIDDIIK 80
Query: 903 IHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAV 962
++ F + ++E S + +G+I ++ F EE ++++Y +C + +A+
Sbjct: 81 VNSRFLHDLQE------TASKEEEQVQLVGNIFLE-FQEE----LEQVYKVYCASYDQAL 129
Query: 963 NLFKELQQNKKFQNFIKLRNSNLL--ARRRGIPECILLVTQRITKYPVLVERILQYTKER 1020
L ++ + Q I+ ++ A G+ +++ QRIT+YP+L+++IL+ T
Sbjct: 130 LLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPD 189
Query: 1021 TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKT 1065
+ L++A+ ++D V+ +NEY+ ++ K+E T
Sbjct: 190 ASAYPVLQRAVSALQD----VNTNINEYKMRKEVASKYTKVEQLT 230
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 [Homo
sapiens]
Length = 596
Score = 67.8 bits (164), Expect = 8e-11
Identities = 53/248 (21%), Positives = 117/248 (47%), Gaps = 14/248 (5%)
Query: 817 SDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFR 876
S + + A+ + WS ++D + I+RQ+ I+E+ + E I+ L + + +
Sbjct: 142 STVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYH 201
Query: 877 KGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILV 936
M + + + IF LD + +H + E + + +++IG ILV
Sbjct: 202 DPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP-------DGTVEQIGHILV 254
Query: 937 QQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECI 996
NA Y +C + A L + +Q+ + Q+F++ + +R+ + +
Sbjct: 255 SWLPRLNA------YRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFL 308
Query: 997 LLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLE 1056
+ R+ KYP+L++ IL++T + + + L A+ +I+ +++ ++LK E E Q +++
Sbjct: 309 DIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESE-CQYYID 367
Query: 1057 ILNKIENK 1064
L ++ K
Sbjct: 368 KLEYLDEK 375
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [Homo
sapiens]
Length = 542
Score = 67.8 bits (164), Expect = 8e-11
Identities = 53/248 (21%), Positives = 117/248 (47%), Gaps = 14/248 (5%)
Query: 817 SDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFR 876
S + + A+ + WS ++D + I+RQ+ I+E+ + E I+ L + + +
Sbjct: 88 STVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYH 147
Query: 877 KGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILV 936
M + + + IF LD + +H + E + + +++IG ILV
Sbjct: 148 DPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP-------DGTVEQIGHILV 200
Query: 937 QQFSEENASKMKKIYGEFCCHHKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECI 996
NA Y +C + A L + +Q+ + Q+F++ + +R+ + +
Sbjct: 201 SWLPRLNA------YRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFL 254
Query: 997 LLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLE 1056
+ R+ KYP+L++ IL++T + + + L A+ +I+ +++ ++LK E E Q +++
Sbjct: 255 DIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESE-CQYYID 313
Query: 1057 ILNKIENK 1064
L ++ K
Sbjct: 314 KLEYLDEK 321
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b [Homo
sapiens]
Length = 626
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/212 (23%), Positives = 101/212 (47%), Gaps = 9/212 (4%)
Query: 842 RQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELL 901
R D + + VI EL+ TE +++ L + E++ + ++ E L ++ +F L E+L
Sbjct: 17 RHLSDADRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEML 76
Query: 902 EIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENA----SKMKKIYGEFCCH 957
E + F ++++ A SD N ++ FS + + K+Y FC +
Sbjct: 77 EFQKVFLETLEDGIS---ASSDFN-TLETPSQFRKLLFSLGGSFLYYADHFKLYSGFCAN 132
Query: 958 HKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYT 1017
H + + + + +K F+ F+ RN + ++ QR+ KYP+L++ ++ T
Sbjct: 133 HIKVQKVLERAKTDKAFKAFLDARNPTK-QHSSTLESYLIKPVQRVLKYPLLLKELVSLT 191
Query: 1018 KERTEEHKDLRKALCLIKDMIATVDLKVNEYE 1049
+ +EEH L +AL ++ + + ++ YE
Sbjct: 192 DQESEEHYHLTEALKAMEKVASHINEMQKIYE 223
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 66.6 bits (161), Expect = 2e-10
Identities = 99/484 (20%), Positives = 198/484 (40%), Gaps = 67/484 (13%)
Query: 785 SRSHSDELLQSMGSSPSTESFIMEDVVDSS-----LWSDLSSDAQEFEAESWSLVVDPSF 839
S+ D++L S T+ VV S WS L VV+
Sbjct: 227 SQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPE------------VVELGI 274
Query: 840 CNRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDE 899
++ + KRQ+ +FE++ +E + +L I+ E F + + + +F + +
Sbjct: 275 LDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILD 334
Query: 900 LLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHH- 958
+L + FF +++R + +++ I DIL EE+A K Y +C +
Sbjct: 335 VLGASQRFFEDLEQRHK-------AQVLVEDISDIL-----EEHAEKHFHPYIAYCSNEV 382
Query: 959 KEAVNLFKELQQNKKFQNFIKLRNSNLLARRRGIP--ECILLVTQRITKYPVLVERILQY 1016
+ L K + N F+ LR G+P ++L QR+T+ P+L++ +
Sbjct: 383 YQQRTLQKLISSNAAFRE--ALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLK 440
Query: 1017 TKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFR 1076
T+ +E +K +AL I ++ + + E+ ++ + +++ ++K+K+
Sbjct: 441 TQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLD---FSKVKS----- 492
Query: 1077 KQALMSEERTLLYDGLVYWKTATGRFKDILA------LLLTDVLLFLQEKDQKYIFAAVD 1130
L+S R LL G ++ TG F+ I + L DVL+ ++K ++
Sbjct: 493 -LPLISASRWLLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDY 551
Query: 1131 QKPSVISLQKLIAREVANEERG-----------MFLISASSAGPEMYEIHTNSKEERNNW 1179
+ + I ++K+ E+ G + L+ S E + ++S +R W
Sbjct: 552 AQMNHIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARW 611
Query: 1180 MRRIQQAVESCPEEKGGRTSESDEDKRK-AEARVAKIQQCQEILTNQDQQICAYLEEKLH 1238
+ A+ + G +S+ D + + +A AK Q E+ Q + +E
Sbjct: 612 I----VALTHSERQWQGLSSKGDLPQVEITKAFFAK--QADEVTLQQADVVLVLQQEDGW 665
Query: 1239 IYAE 1242
+Y E
Sbjct: 666 LYGE 669
>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
Length = 961
Score = 65.9 bits (159), Expect = 3e-10
Identities = 89/390 (22%), Positives = 154/390 (39%), Gaps = 57/390 (14%)
Query: 817 SDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQDVIF----ELMQTEMHHIQTLFIMS 872
SDL + E E E + RQE + Q +F EL+QTE ++ L ++
Sbjct: 337 SDLEEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLD 396
Query: 873 EIFRKGMKEELQLDHS----TVDKIFPCLDELLEIHRHFFYSMKERRQESCAGSDRNFVI 928
++F + EE + S V IF + + H+ F E+R E DR
Sbjct: 397 QVFCARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEW---DR---Y 450
Query: 929 DRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKE-LQQNKKFQNFIKLRNSNLLA 987
RIGDIL + + K+YGE+ + AV L +++ +F+ I
Sbjct: 451 PRIGDIL------QKLAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEAC 504
Query: 988 RRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKALCLIKDMIATVDLKVNE 1047
+ +L QRI +Y +L++ L + + KD +K+L LI + + +
Sbjct: 505 GNLTLQHHMLEPVQRIPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRK 564
Query: 1048 YEKNQKWLEIL------NKIENKTYTKLKNGHVFRKQALMSEERTLLYDGLVYWKTATGR 1101
E+ K L++ I + T +K GH+ + A G
Sbjct: 565 MERMHKLLKVYELLGGEEDIVSPTKELIKEGHILKLSA------------------KNGT 606
Query: 1102 FKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSV---ISLQKLIAREVAN-EERGMFLIS 1157
+D +L D LL+ + + QK SV I + + +E +N FL+S
Sbjct: 607 TQDRYLILFNDRLLYCVPR-----LRLLGQKFSVRARIDVDGMELKESSNLNLPRTFLVS 661
Query: 1158 ASSAGPEMYEIHTNSKEERNNWMRRIQQAV 1187
E+ ++EE+ +W++ I +
Sbjct: 662 GKQ---RSLELQARTEEEKKDWVQAINSTL 688
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 65.5 bits (158), Expect = 4e-10
Identities = 60/227 (26%), Positives = 110/227 (48%), Gaps = 28/227 (12%)
Query: 844 EKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGM------KEELQLDHSTVDKIFPCL 897
EK + R V+ EL +TE ++ TL + F M K + + TV +F +
Sbjct: 18 EKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNI 77
Query: 898 DELLEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCH 957
+++L +H+ F ++E C + N +G + F ++ +IY E+C +
Sbjct: 78 EDILAVHKEFLKVVEE-----CLHPEPN-AQQEVGTCFLH-FKDKF-----RIYDEYCSN 125
Query: 958 HKEAVNLFKELQQNKKFQNFIKLRNSNLLARRRG--IPECILLVT--QRITKYPVLVERI 1013
H++A L EL + + + F L N LL R+ +P LVT QRI KYP++++ +
Sbjct: 126 HEKAQKLLLELNKIRTIRTF--LLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKEL 183
Query: 1014 LQYTKERTEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNK 1060
L+ T + ++ + +AL +K V +NE ++ + LE+L +
Sbjct: 184 LKRTPRKHSDYAAVMEALQAMK----AVCSNINEAKRQMEKLEVLEE 226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,117,508
Number of Sequences: 37866
Number of extensions: 3001363
Number of successful extensions: 14729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 437
Number of HSP's that attempted gapping in prelim test: 10890
Number of HSP's gapped (non-prelim): 2662
length of query: 1651
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1535
effective length of database: 13,855,062
effective search space: 21267520170
effective search space used: 21267520170
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.