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Search of human proteins with 32479527
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32479527 potassium voltage-gated channel, KQT-like
subfamily, member 1 isoform 1 [Homo sapiens]
(676 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32479527 potassium voltage-gated channel, KQT-like subfamily,... 1363 0.0
gi|32479525 potassium voltage-gated channel, KQT-like subfamily,... 1094 0.0
gi|236461719 potassium voltage-gated channel, KQT-like subfamily... 415 e-116
gi|28373065 potassium voltage-gated channel, KQT-like subfamily,... 413 e-115
gi|26638655 potassium voltage-gated channel KQT-like protein 4 i... 413 e-115
gi|236461942 potassium voltage-gated channel, KQT-like subfamily... 411 e-114
gi|236462079 potassium voltage-gated channel, KQT-like subfamily... 408 e-114
gi|26051260 potassium voltage-gated channel KQT-like protein 2 i... 405 e-113
gi|26051262 potassium voltage-gated channel KQT-like protein 2 i... 400 e-111
gi|26638653 potassium voltage-gated channel KQT-like protein 4 i... 397 e-110
gi|26051266 potassium voltage-gated channel KQT-like protein 2 i... 395 e-110
gi|4758630 potassium voltage-gated channel KQT-like protein 3 [H... 363 e-100
gi|236462242 potassium voltage-gated channel, KQT-like subfamily... 352 8e-97
gi|26051268 potassium voltage-gated channel KQT-like protein 2 i... 345 8e-95
gi|26051264 potassium voltage-gated channel KQT-like protein 2 i... 345 8e-95
gi|88758565 potassium voltage-gated channel, shaker-related subf... 95 2e-19
gi|9789987 potassium voltage-gated channel, Shal-related subfami... 94 5e-19
gi|4826782 potassium voltage-gated channel, shaker-related subfa... 93 7e-19
gi|4504817 potassium voltage-gated channel, shaker-related subfa... 92 1e-18
gi|27436981 potassium voltage-gated channel, Shal-related subfam... 92 2e-18
gi|88758576 Shaw-related voltage-gated potassium channel protein... 92 2e-18
gi|24497462 Shaw-related voltage-gated potassium channel protein... 92 2e-18
gi|119395748 potassium voltage-gated channel subfamily A member ... 92 2e-18
gi|27436984 potassium voltage-gated channel, Shal-related subfam... 91 5e-18
gi|27436986 potassium voltage-gated channel, Shal-related subfam... 91 5e-18
gi|4504821 potassium voltage-gated channel, shaker-related subfa... 90 6e-18
gi|25952087 potassium voltage-gated channel, shaker-related subf... 89 1e-17
gi|25952092 potassium voltage-gated channel, shaker-related subf... 89 1e-17
gi|27436974 potassium voltage-gated channel, Shab-related subfam... 88 2e-17
gi|21217561 Shaw-related voltage-gated potassium channel protein... 87 4e-17
>gi|32479527 potassium voltage-gated channel, KQT-like subfamily,
member 1 isoform 1 [Homo sapiens]
Length = 676
Score = 1363 bits (3528), Expect = 0.0
Identities = 676/676 (100%), Positives = 676/676 (100%)
Query: 1 MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG 60
MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
Sbjct: 1 MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG 60
Query: 61 PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW 120
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
Sbjct: 61 PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW 120
Query: 121 KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC 180
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
Sbjct: 121 KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC 180
Query: 181 RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH 240
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
Sbjct: 181 RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH 240
Query: 241 VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA 300
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
Sbjct: 241 VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA 300
Query: 301 DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR 360
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
Sbjct: 301 DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR 360
Query: 361 QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK 420
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
Sbjct: 361 QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK 420
Query: 421 KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM 480
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
Sbjct: 421 KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM 480
Query: 481 RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD 540
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
Sbjct: 481 RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD 540
Query: 541 VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT 600
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
Sbjct: 541 VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT 600
Query: 601 QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP 660
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
Sbjct: 601 QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP 660
Query: 661 TYEQLTVPRRGPDEGS 676
TYEQLTVPRRGPDEGS
Sbjct: 661 TYEQLTVPRRGPDEGS 676
>gi|32479525 potassium voltage-gated channel, KQT-like subfamily,
member 1 isoform 2 [Homo sapiens]
Length = 549
Score = 1094 bits (2830), Expect = 0.0
Identities = 547/547 (100%), Positives = 547/547 (100%)
Query: 130 FLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWG 189
FLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWG
Sbjct: 3 FLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWG 62
Query: 190 RLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWR 249
RLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWR
Sbjct: 63 RLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWR 122
Query: 250 LLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVT 309
LLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVT
Sbjct: 123 LLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVT 182
Query: 310 VTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIP 369
VTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIP
Sbjct: 183 VTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIP 242
Query: 370 AAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDN 429
AAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDN
Sbjct: 243 AAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDN 302
Query: 430 GVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDL 489
GVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDL
Sbjct: 303 GVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAEDL 362
Query: 490 DLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGH 549
DLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGH
Sbjct: 363 DLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGH 422
Query: 550 LNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALI 609
LNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALI
Sbjct: 423 LNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVTQLDQRLALI 482
Query: 610 TDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPTYEQLTVPR 669
TDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPTYEQLTVPR
Sbjct: 483 TDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLPTYEQLTVPR 542
Query: 670 RGPDEGS 676
RGPDEGS
Sbjct: 543 RGPDEGS 549
>gi|236461719 potassium voltage-gated channel, KQT-like subfamily,
member 5 isoform 2 [Homo sapiens]
Length = 923
Score = 415 bits (1066), Expect = e-116
Identities = 239/540 (44%), Positives = 339/540 (62%), Gaps = 29/540 (5%)
Query: 92 SIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAAL 151
S S RR V R VQ +YN LERP GW F+YH VFL+V CLI SV STI ++ L
Sbjct: 98 SSQSCRRNVKYR-RVQNYLYNVLERPRGW-AFIYHAFVFLLVFGCLILSVFSTIPEHTKL 155
Query: 152 ATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV 211
A+ L +E V++V FG E+++R+WSAGC +Y G GRLRFARKP +ID IV++AS+
Sbjct: 156 ASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIA 215
Query: 212 VLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 271
V+ ++G +FATSA+R +RFLQILRM+ +DR+GGTW+LLGSVV+ H +ELIT YIGFL
Sbjct: 216 VVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFL 275
Query: 272 GLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASC 331
LIFSS+ VYL EKDA EF +YADALWWG +T+TTIGYGDK P TW+G+ +++
Sbjct: 276 VLIFSSFLVYLVEKDA-----NKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAG 330
Query: 332 FSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSS- 390
F++ ISFFALPAGILGSGFALKVQ++ RQKHF ++ AA+LIQ WR YAA+ S
Sbjct: 331 FALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSI 390
Query: 391 -TWKIYIRKAPRSHTLLSPSPKP--KKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDP 447
TWK +++ HT + K K+ V + + + K + G++ IT +
Sbjct: 391 ATWKPHLKAL---HTCSPTNQKLSFKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEG 447
Query: 448 PEERRLDHFSVDGYDSSVRKSPTL-LEVSMPH-FMRTNSFAEDLDLEGETLLTPITHISQ 505
+ +S ++ R P+L L+ S P + ++ D+ E +
Sbjct: 448 SPTKVQKSWS---FNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQCDVSVED 504
Query: 506 LREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQ 565
L + I+ IR M++ VAK+KF++ +PYDV+DVIEQYS GHL+++ RIK LQ R+DQ
Sbjct: 505 LTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQ 564
Query: 566 SIGKPSLFISVSEKSKDR--------GSNTIGARLNRVEDKVTQLDQRLALITDMLHQLL 617
+GK I+ +KS+++ ++ R+ +VE +V ++ +L + D+ Q+L
Sbjct: 565 ILGKGQ--ITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVL 622
>gi|28373065 potassium voltage-gated channel, KQT-like subfamily,
member 5 isoform 1 [Homo sapiens]
Length = 932
Score = 413 bits (1062), Expect = e-115
Identities = 238/546 (43%), Positives = 338/546 (61%), Gaps = 32/546 (5%)
Query: 92 SIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAAL 151
S S RR V R VQ +YN LERP GW F+YH VFL+V CLI SV STI ++ L
Sbjct: 98 SSQSCRRNVKYR-RVQNYLYNVLERPRGW-AFIYHAFVFLLVFGCLILSVFSTIPEHTKL 155
Query: 152 ATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV 211
A+ L +E V++V FG E+++R+WSAGC +Y G GRLRFARKP +ID IV++AS+
Sbjct: 156 ASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIA 215
Query: 212 VLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 271
V+ ++G +FATSA+R +RFLQILRM+ +DR+GGTW+LLGSVV+ H +ELIT YIGFL
Sbjct: 216 VVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFL 275
Query: 272 GLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASC 331
LIFSS+ VYL EKDA EF +YADALWWG +T+TTIGYGDK P TW+G+ +++
Sbjct: 276 VLIFSSFLVYLVEKDA-----NKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAG 330
Query: 332 FSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSS- 390
F++ ISFFALPAGILGSGFALKVQ++ RQKHF ++ AA+LIQ WR YAA+ S
Sbjct: 331 FALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSI 390
Query: 391 -TWKIYIR--------KAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVP 441
TWK +++ K + S K+ V + + + K + G++
Sbjct: 391 ATWKPHLKALHTCSPTKKEQGEASSSQKLSFKERVRMASPRGQSIKSRQASVGDRRSPST 450
Query: 442 HITCDPPEERRLDHFSVDGYDSSVRKSPTL-LEVSMPH-FMRTNSFAEDLDLEGETLLTP 499
IT + + +S ++ R P+L L+ S P + ++ D+ E
Sbjct: 451 DITAEGSPTKVQKSWS---FNDRTRFRPSLRLKSSQPKPVIDADTALGTDDVYDEKGCQC 507
Query: 500 ITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKEL 559
+ L + I+ IR M++ VAK+KF++ +PYDV+DVIEQYS GHL+++ RIK L
Sbjct: 508 DVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSL 567
Query: 560 QRRLDQSIGKPSLFISVSEKSKDR--------GSNTIGARLNRVEDKVTQLDQRLALITD 611
Q R+DQ +GK I+ +KS+++ ++ R+ +VE +V ++ +L + D
Sbjct: 568 QTRVDQILGKGQ--ITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLD 625
Query: 612 MLHQLL 617
+ Q+L
Sbjct: 626 IYQQVL 631
>gi|26638655 potassium voltage-gated channel KQT-like protein 4
isoform b [Homo sapiens]
Length = 641
Score = 413 bits (1062), Expect = e-115
Identities = 258/639 (40%), Positives = 359/639 (56%), Gaps = 91/639 (14%)
Query: 4 ASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGA--------LYAPIA 55
A +PPR R G G PG A A+ + +E G AGG L +P+
Sbjct: 2 AEAPPR----RLGLGPPPG----DAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLP 53
Query: 56 PGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLE 115
PGAP P P + + R S R +Q VYN LE
Sbjct: 54 PGAPLPGPGSGSGSACGQ----------------RSSAAHKRY-----RRLQNWVYNVLE 92
Query: 116 RPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRL 175
RP GW FVYH +FL+V CL+ SVLSTI+++ LA L +E V++V FG EY+VR+
Sbjct: 93 RPRGW-AFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRV 151
Query: 176 WSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQI 235
WSAGC +Y G GR RFARKP +ID IV VAS+ V+ G++G +FATSA+R +RFLQI
Sbjct: 152 WSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQI 211
Query: 236 LRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVE 295
LRM+ +DR+GGTW+LLGSVV+ H +ELIT YIGFL LIF+S+ VYLAEKDA +
Sbjct: 212 LRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDA-----NSD 266
Query: 296 FGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKV 355
F SYAD+LWWG +T+TTIGYGDK P TW+G+ +A+ F++ ISFFALPAGILGSGFALKV
Sbjct: 267 FSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKV 326
Query: 356 QQKQRQKHFNRQIPAAASLIQTAWRCYAAENPD---SSTWKIYIRKAPRSHTLLSPSPKP 412
Q++ RQKHF ++ AA+LIQ AWR Y+ + ++TW Y + PS
Sbjct: 327 QEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYY--------DSILPSFSS 378
Query: 413 KKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLL 472
+ + + + + G P ++ L P + P E+ SPT +
Sbjct: 379 RMGIKDRIRMGSSQRRTG--PSKQHLAPPTMPTSPSSEQ-----------VGEATSPTKV 425
Query: 473 EVSMPHFMRTNSFAEDLDLEGETLL--TPITHISQLREHH------------RATIKVIR 518
+ S RT F L L+ T P +++ + + + I+ IR
Sbjct: 426 QKSWSFNDRTR-FRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIR 484
Query: 519 RMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSE 578
+++ VAK+KF++ +PYDV+DVIEQYS GHL+++ RIK LQ R+DQ +G+ E
Sbjct: 485 ILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKARE 544
Query: 579 KSKDRGSN--------TIGARLNRVEDKVTQLDQRLALI 609
K D+G + ++ R+ +VE +V ++ +L L+
Sbjct: 545 KG-DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLL 582
>gi|236461942 potassium voltage-gated channel, KQT-like subfamily,
member 5 isoform 3 [Homo sapiens]
Length = 942
Score = 411 bits (1056), Expect = e-114
Identities = 241/556 (43%), Positives = 341/556 (61%), Gaps = 42/556 (7%)
Query: 92 SIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAAL 151
S S RR V R VQ +YN LERP GW F+YH VFL+V CLI SV STI ++ L
Sbjct: 98 SSQSCRRNVKYR-RVQNYLYNVLERPRGW-AFIYHAFVFLLVFGCLILSVFSTIPEHTKL 155
Query: 152 ATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV 211
A+ L +E V++V FG E+++R+WSAGC +Y G GRLRFARKP +ID IV++AS+
Sbjct: 156 ASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIA 215
Query: 212 VLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 271
V+ ++G +FATSA+R +RFLQILRM+ +DR+GGTW+LLGSVV+ H +ELIT YIGFL
Sbjct: 216 VVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFL 275
Query: 272 GLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASC 331
LIFSS+ VYL EKDA EF +YADALWWG +T+TTIGYGDK P TW+G+ +++
Sbjct: 276 VLIFSSFLVYLVEKDA-----NKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAG 330
Query: 332 FSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSS- 390
F++ ISFFALPAGILGSGFALKVQ++ RQKHF ++ AA+LIQ WR YAA+ S
Sbjct: 331 FALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSI 390
Query: 391 -TWKIYIR----------------KAPRSHTLLSPSPKP--KKSVVVKKKKFKLDKDNGV 431
TWK +++ K R +T S K K+ V + + + K
Sbjct: 391 ATWKPHLKALHTCSPTNKFCSNKQKLFRMYTSRKQSQKLSFKERVRMASPRGQSIKSRQA 450
Query: 432 TPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTL-LEVSMPH-FMRTNSFAEDL 489
+ G++ IT + + +S ++ R P+L L+ S P + ++
Sbjct: 451 SVGDRRSPSTDITAEGSPTKVQKSWS---FNDRTRFRPSLRLKSSQPKPVIDADTALGTD 507
Query: 490 DLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGH 549
D+ E + L + I+ IR M++ VAK+KF++ +PYDV+DVIEQYS GH
Sbjct: 508 DVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPYDVKDVIEQYSAGH 567
Query: 550 LNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDR--------GSNTIGARLNRVEDKVTQ 601
L+++ RIK LQ R+DQ +GK I+ +KS+++ ++ R+ +VE +V
Sbjct: 568 LDMLCRIKSLQTRVDQILGKGQ--ITSDKKSREKITAEHETTDDLSMLGRVVKVEKQVQS 625
Query: 602 LDQRLALITDMLHQLL 617
++ +L + D+ Q+L
Sbjct: 626 IESKLDCLLDIYQQVL 641
>gi|236462079 potassium voltage-gated channel, KQT-like subfamily,
member 5 isoform 4 [Homo sapiens]
Length = 951
Score = 408 bits (1049), Expect = e-114
Identities = 242/569 (42%), Positives = 332/569 (58%), Gaps = 59/569 (10%)
Query: 92 SIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAAL 151
S S RR V R VQ +YN LERP GW F+YH VFL+V CLI SV STI ++ L
Sbjct: 98 SSQSCRRNVKYR-RVQNYLYNVLERPRGW-AFIYHAFVFLLVFGCLILSVFSTIPEHTKL 155
Query: 152 ATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV 211
A+ L +E V++V FG E+++R+WSAGC +Y G GRLRFARKP +ID IV++AS+
Sbjct: 156 ASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIA 215
Query: 212 VLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 271
V+ ++G +FATSA+R +RFLQILRM+ +DR+GGTW+LLGSVV+ H +ELIT YIGFL
Sbjct: 216 VVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFL 275
Query: 272 GLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASC 331
LIFSS+ VYL EKDA EF +YADALWWG +T+TTIGYGDK P TW+G+ +++
Sbjct: 276 VLIFSSFLVYLVEKDA-----NKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAG 330
Query: 332 FSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSS- 390
F++ ISFFALPAGILGSGFALKVQ++ RQKHF ++ AA+LIQ WR YAA+ S
Sbjct: 331 FALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSI 390
Query: 391 -TWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKD------NGVTPGEKMLTVPHI 443
TWK P L + SP K+ KF +K +K+ +
Sbjct: 391 ATWK------PHLKALHTCSPTKKEQGEASSSKFCSNKQKLFRMYTSRKQSQKLSFKERV 444
Query: 444 TCDPPEERRLDHFSVD-------GYDSSVRKSPTLLEVSMPHFMRTNSFAEDLDLEGETL 496
P + + D + SPT ++ S RT F L L+
Sbjct: 445 RMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTR-FRPSLRLKSSQP 503
Query: 497 LTPI--------------------THISQLREHHRATIKVIRRMQYFVAKKKFQQARKPY 536
I + L + I+ IR M++ VAK+KF++ +PY
Sbjct: 504 KPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKETLRPY 563
Query: 537 DVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDR--------GSNTI 588
DV+DVIEQYS GHL+++ RIK LQ R+DQ +GK I+ +KS+++ ++
Sbjct: 564 DVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQ--ITSDKKSREKITAEHETTDDLSM 621
Query: 589 GARLNRVEDKVTQLDQRLALITDMLHQLL 617
R+ +VE +V ++ +L + D+ Q+L
Sbjct: 622 LGRVVKVEKQVQSIESKLDCLLDIYQQVL 650
>gi|26051260 potassium voltage-gated channel KQT-like protein 2
isoform c [Homo sapiens]
Length = 844
Score = 405 bits (1040), Expect = e-113
Identities = 241/605 (39%), Positives = 354/605 (58%), Gaps = 57/605 (9%)
Query: 61 PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTH---VQGRVYNFLERP 117
P P S A S+ R + PR +P +Q +YN LERP
Sbjct: 29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERP 88
Query: 118 TGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWS 177
GW F+YH VFL+V CL+ SV STI++Y + G L+ +EIV +V FG EY VR+W+
Sbjct: 89 RGW-AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWA 147
Query: 178 AGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILR 237
AGC +Y G GRL+FARKP +ID++V++AS+ VL GS+G VFATSA+R +RFLQILR
Sbjct: 148 AGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILR 207
Query: 238 MLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFG 297
M+ +DR+GGTW+LLGSVV+ H +EL+T YIGFL LI +S+ VYLAEK + F
Sbjct: 208 MIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGEND-----HFD 262
Query: 298 SYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQ 357
+YADALWWG++T+TTIGYGDK PQTW G+ +A+ F++ +SFFALPAGILGSGFALKVQ+
Sbjct: 263 TYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQE 322
Query: 358 KQRQKHFNRQIPAAASLIQTAWRCYA---AENPDSSTWKIYIRKAP-RSHTLLSPSPKPK 413
+ RQKHF ++ AA LIQ+AWR YA + STW+ Y R + L+ P + +
Sbjct: 323 QHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYRLIPPLNQLE 382
Query: 414 KSVVVKKKK---FKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPT 470
+K K F+ D +P +K+ + P S +VR+SP+
Sbjct: 383 LLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQA--QTVRRSPS 440
Query: 471 L---LEVSMPHFMRTNSF--------------------AEDLDLEGETLL----TPITHI 503
LE S ++ SF +E+ L GE ++ P +
Sbjct: 441 ADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFV 500
Query: 504 SQ-LREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRR 562
++ L + +I+ + M++ V+K+KF+++ +PYDV DVIEQYS GHL+++ RIK LQ R
Sbjct: 501 TEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSR 560
Query: 563 LDQSIGKPSLFISVSEKSKDRG--------SNTIGARLNRVEDKVTQLDQRLALITDMLH 614
+DQ +G+ ++++K + +G ++ RL +VE +V ++++L + ++
Sbjct: 561 VDQIVGRGP---AITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYM 617
Query: 615 QLLSL 619
Q + +
Sbjct: 618 QRMGI 622
>gi|26051262 potassium voltage-gated channel KQT-like protein 2
isoform b [Homo sapiens]
Length = 854
Score = 400 bits (1029), Expect = e-111
Identities = 241/615 (39%), Positives = 355/615 (57%), Gaps = 67/615 (10%)
Query: 61 PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTH---VQGRVYNFLERP 117
P P S A S+ R + PR +P +Q +YN LERP
Sbjct: 29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERP 88
Query: 118 TGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWS 177
GW F+YH VFL+V CL+ SV STI++Y + G L+ +EIV +V FG EY VR+W+
Sbjct: 89 RGW-AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWA 147
Query: 178 AGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILR 237
AGC +Y G GRL+FARKP +ID++V++AS+ VL GS+G VFATSA+R +RFLQILR
Sbjct: 148 AGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILR 207
Query: 238 MLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFG 297
M+ +DR+GGTW+LLGSVV+ H +EL+T YIGFL LI +S+ VYLAEK + F
Sbjct: 208 MIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGEND-----HFD 262
Query: 298 SYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQ 357
+YADALWWG++T+TTIGYGDK PQTW G+ +A+ F++ +SFFALPAGILGSGFALKVQ+
Sbjct: 263 TYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQE 322
Query: 358 KQRQKHFNRQIPAAASLIQTAWRCYA---AENPDSSTWKIYIR-----------KAPRSH 403
+ RQKHF ++ AA LIQ+AWR YA + STW+ Y R + +
Sbjct: 323 QHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGAS 382
Query: 404 TLLSPSPKPKKSVVVKKKK---FKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDG 460
L+ P + + +K K F+ D +P +K+ + P S
Sbjct: 383 RLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVAAKGKGSPQA 442
Query: 461 YDSSVRKSPTL---LEVSMPHFMRTNSF--------------------AEDLDLEGETLL 497
+VR+SP+ LE S ++ SF +E+ L GE ++
Sbjct: 443 --QTVRRSPSADQSLEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIV 500
Query: 498 ----TPITHISQ-LREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNL 552
P +++ L + +I+ + M++ V+K+KF+++ +PYDV DVIEQYS GHL++
Sbjct: 501 DDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDM 560
Query: 553 MVRIKELQRRLDQSIGKPSLFISVSEKSKDRG--------SNTIGARLNRVEDKVTQLDQ 604
+ RIK LQ R+DQ +G+ ++++K + +G ++ RL +VE +V +++
Sbjct: 561 LSRIKSLQSRVDQIVGRGP---AITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEK 617
Query: 605 RLALITDMLHQLLSL 619
+L + ++ Q + +
Sbjct: 618 KLDFLVNIYMQRMGI 632
>gi|26638653 potassium voltage-gated channel KQT-like protein 4
isoform a [Homo sapiens]
Length = 695
Score = 397 bits (1021), Expect = e-110
Identities = 264/683 (38%), Positives = 362/683 (53%), Gaps = 125/683 (18%)
Query: 4 ASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGA--------LYAPIA 55
A +PPR R G G PG A A+ + +E G AGG L +P+
Sbjct: 2 AEAPPR----RLGLGPPPG----DAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLP 53
Query: 56 PGAPGPAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLE 115
PGAP P P + + R S R +Q VYN LE
Sbjct: 54 PGAPLPGPGSGSGSACGQ----------------RSSAAHKRY-----RRLQNWVYNVLE 92
Query: 116 RPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRL 175
RP GW FVYH +FL+V CL+ SVLSTI+++ LA L +E V++V FG EY+VR+
Sbjct: 93 RPRGW-AFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRV 151
Query: 176 WSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQI 235
WSAGC +Y G GR RFARKP +ID IV VAS+ V+ G++G +FATSA+R +RFLQI
Sbjct: 152 WSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQI 211
Query: 236 LRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVE 295
LRM+ +DR+GGTW+LLGSVV+ H +ELIT YIGFL LIF+S+ VYLAEKDA +
Sbjct: 212 LRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDA-----NSD 266
Query: 296 FGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKV 355
F SYAD+LWWG +T+TTIGYGDK P TW+G+ +A+ F++ ISFFALPAGILGSGFALKV
Sbjct: 267 FSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKV 326
Query: 356 QQKQRQKHFNRQIPAAASLIQTAWRCYAAENPD---SSTWKIY----------------- 395
Q++ RQKHF ++ AA+LIQ AWR Y+ + ++TW Y
Sbjct: 327 QEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHV 386
Query: 396 ------------IRKAP-------------RSHTLLSPS--PKPKKSVVVKKKKFKLDKD 428
+R+AP H S S P + +K +
Sbjct: 387 QRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQ 446
Query: 429 NGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFMRTNSFAED 488
P ++ L P + P E+ SPT ++ S RT F
Sbjct: 447 RRTGPSKQHLAPPTMPTSPSSEQ-----------VGEATSPTKVQKSWSFNDRTR-FRAS 494
Query: 489 LDLEGETLL--TPITHISQLREHH---------RATIKVIRRMQ---YFVAKKKFQQARK 534
L L+ T P +++ + + A VIR ++ + VAK+KF++ +
Sbjct: 495 LRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLR 554
Query: 535 PYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSN-------- 586
PYDV+DVIEQYS GHL+++ RIK LQ R+DQ +G+ EK D+G +
Sbjct: 555 PYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG-DKGPSDAEVVDEI 613
Query: 587 TIGARLNRVEDKVTQLDQRLALI 609
++ R+ +VE +V ++ +L L+
Sbjct: 614 SMMGRVVKVEKQVQSIEHKLDLL 636
>gi|26051266 potassium voltage-gated channel KQT-like protein 2
isoform d [Homo sapiens]
Length = 841
Score = 395 bits (1016), Expect = e-110
Identities = 234/600 (39%), Positives = 343/600 (57%), Gaps = 50/600 (8%)
Query: 61 PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTH---VQGRVYNFLERP 117
P P S A S+ R + PR +P +Q +YN LERP
Sbjct: 29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERP 88
Query: 118 TGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWS 177
GW F+YH VFL+V CL+ SV STI++Y + G L+ +EIV +V FG EY VR+W+
Sbjct: 89 RGW-AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWA 147
Query: 178 AGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILR 237
AGC +Y G GRL+FARKP +ID++V++AS+ VL GS+G VFATSA+R +RFLQILR
Sbjct: 148 AGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILR 207
Query: 238 MLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFG 297
M+ +DR+GGTW+LLGSVV+ H +EL+T YIGFL LI +S+ VYLAEK + F
Sbjct: 208 MIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGEND-----HFD 262
Query: 298 SYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQ 357
+YADALWWG++T+TTIGYGDK PQTW G+ +A+ F++ +SFFALPAGILGSGFALKVQ+
Sbjct: 263 TYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQE 322
Query: 358 KQRQKHFNRQIPAAASLIQTAWRCYA---AENPDSSTWKIYIRKAPRSHTLLSPSPKPKK 414
+ RQKHF ++ AA LIQ+AWR YA + STW+ Y R
Sbjct: 323 QHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQTYGAS 382
Query: 415 SVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTL--- 471
++ + +L ++ G P P +VR+SP+
Sbjct: 383 RLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSPRGVAAKGKGSPQAQTVRRSPSADQS 442
Query: 472 LEVSMPHFMRTNSFAE-------------------DLDLEGETLL----TPITHISQ-LR 507
LE S ++ SF + + L GE ++ P +++ L
Sbjct: 443 LEDSPSKVPKSWSFGDRSRARQAFRIKGAASRQNSEASLPGEDIVDDKSCPCEFVTEDLT 502
Query: 508 EHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSI 567
+ +I+ + M++ V+K+KF+++ +PYDV DVIEQYS GHL+++ RIK LQ R+DQ +
Sbjct: 503 PGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIV 562
Query: 568 GKPSLFISVSEKSKDRG--------SNTIGARLNRVEDKVTQLDQRLALITDMLHQLLSL 619
G+ ++++K + +G ++ RL +VE +V ++++L + ++ Q + +
Sbjct: 563 GRGP---AITDKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGI 619
>gi|4758630 potassium voltage-gated channel KQT-like protein 3 [Homo
sapiens]
Length = 872
Score = 363 bits (931), Expect = e-100
Identities = 211/504 (41%), Positives = 294/504 (58%), Gaps = 45/504 (8%)
Query: 106 VQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVV 165
+Q +Y+ LERP GW +YH VFLIVL CLI +VL+T ++Y ++ L +E +
Sbjct: 107 IQTLIYDALERPRGW-ALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIF 165
Query: 166 FFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATS 225
FG E+ +R+W+AGC +Y G GRL+FARKP+ ++D+ V++AS+ V+ VG++G V ATS
Sbjct: 166 IFGAEFALRIWAAGCCCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATS 225
Query: 226 AIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEK 285
+R +RFLQILRML +DR+GGTW+LLGS + H +ELIT YIGFL LI SS+ VYL EK
Sbjct: 226 -LRSLRFLQILRMLRMDRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEK 284
Query: 286 D-----AVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFF 340
D A E + EF +YADALWWG++T+ TIGYGDK P+TW G+ IA+ FS+ +SFF
Sbjct: 285 DVPEVDAQGEEMKEEFETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFF 344
Query: 341 ALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDS----STWKIYI 396
ALPAGILGSG ALKVQ++ RQKHF ++ AA LIQ AWR YA NP+ +TW+ Y
Sbjct: 345 ALPAGILGSGLALKVQEQHRQKHFEKRRKPAAELIQAAWRYYAT-NPNRIDLVATWRFYE 403
Query: 397 RKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHF 456
+ + +L G K+ T
Sbjct: 404 SVVSFPFFRKEQLEAASSQKLGLLDRVRLSNPRGSNTKGKLFT---------------PL 448
Query: 457 SVDGYDSSVRKSPTLLEVSMPHFMRT----NSFAEDLDLEGETLLTPITH---------I 503
+VD + S K P + ++ RT ++A E P+ I
Sbjct: 449 NVDAIEESPSKEPKPVGLNNKERFRTAFRMKAYAFWQSSEDAGTGDPMAEDRGYGNDFPI 508
Query: 504 SQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRL 563
+ +A I+ +R +Q+ + KKKF++ +PYDV+DVIEQYS GHL+++ RIK LQ R+
Sbjct: 509 EDMIPTLKAAIRAVRILQFRLYKKKFKETLRPYDVKDVIEQYSAGHLDMLSRIKYLQTRI 568
Query: 564 DQ--SIGKPSLFISVSEKSKDRGS 585
D + G PS + K +GS
Sbjct: 569 DMIFTPGPPS---TPKHKKSQKGS 589
>gi|236462242 potassium voltage-gated channel, KQT-like subfamily,
member 5 isoform 5 [Homo sapiens]
Length = 822
Score = 352 bits (902), Expect = 8e-97
Identities = 184/338 (54%), Positives = 238/338 (70%), Gaps = 13/338 (3%)
Query: 92 SIYSTRRPVLARTHVQGRVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAAL 151
S S RR V R VQ +YN LERP GW F+YH VFL+V CLI SV STI ++ L
Sbjct: 98 SSQSCRRNVKYR-RVQNYLYNVLERPRGW-AFIYHAFVFLLVFGCLILSVFSTIPEHTKL 155
Query: 152 ATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV 211
A+ L +E V++V FG E+++R+WSAGC +Y G GRLRFARKP +ID IV++AS+
Sbjct: 156 ASSCLLILEFVMIVVFGLEFIIRIWSAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIA 215
Query: 212 VLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 271
V+ ++G +FATSA+R +RFLQILRM+ +DR+GGTW+LLGSVV+ H +ELIT YIGFL
Sbjct: 216 VVSAKTQGNIFATSALRSLRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFL 275
Query: 272 GLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASC 331
LIFSS+ VYL EKDA EF +YADALWWG +T+TTIGYGDK P TW+G+ +++
Sbjct: 276 VLIFSSFLVYLVEKDA-----NKEFSTYADALWWGTITLTTIGYGDKTPLTWLGRLLSAG 330
Query: 332 FSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSS- 390
F++ ISFFALPAGILGSGFALKVQ++ RQKHF ++ AA+LIQ WR YAA+ S
Sbjct: 331 FALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAANLIQCVWRSYAADEKSVSI 390
Query: 391 -TWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDK 427
TWK +++ HT SP+ K + + KF + K
Sbjct: 391 ATWKPHLKAL---HT-CSPTKKEQGEASSRIMKFHVAK 424
Score = 78.2 bits (191), Expect = 2e-14
Identities = 42/108 (38%), Positives = 70/108 (64%), Gaps = 10/108 (9%)
Query: 518 RRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVS 577
R M++ VAK+KF++ +PYDV+DVIEQYS GHL+++ RIK LQ R+DQ +GK I+
Sbjct: 416 RIMKFHVAKRKFKETLRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQ--ITSD 473
Query: 578 EKSKDR--------GSNTIGARLNRVEDKVTQLDQRLALITDMLHQLL 617
+KS+++ ++ R+ +VE +V ++ +L + D+ Q+L
Sbjct: 474 KKSREKITAEHETTDDLSMLGRVVKVEKQVQSIESKLDCLLDIYQQVL 521
>gi|26051268 potassium voltage-gated channel KQT-like protein 2
isoform e [Homo sapiens]
Length = 393
Score = 345 bits (885), Expect = 8e-95
Identities = 178/343 (51%), Positives = 232/343 (67%), Gaps = 12/343 (3%)
Query: 61 PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTH---VQGRVYNFLERP 117
P P S A S+ R + PR +P +Q +YN LERP
Sbjct: 29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERP 88
Query: 118 TGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWS 177
GW F+YH VFL+V CL+ SV STI++Y + G L+ +EIV +V FG EY VR+W+
Sbjct: 89 RGW-AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWA 147
Query: 178 AGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILR 237
AGC +Y G GRL+FARKP +ID++V++AS+ VL GS+G VFATSA+R +RFLQILR
Sbjct: 148 AGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILR 207
Query: 238 MLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFG 297
M+ +DR+GGTW+LLGSVV+ H +EL+T YIGFL LI +S+ VYLAEK + F
Sbjct: 208 MIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGEND-----HFD 262
Query: 298 SYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQ 357
+YADALWWG++T+TTIGYGDK PQTW G+ +A+ F++ +SFFALPAGILGSGFALKVQ+
Sbjct: 263 TYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQE 322
Query: 358 KQRQKHFNRQIPAAASLIQTAWRCYA---AENPDSSTWKIYIR 397
+ RQKHF ++ AA LIQ+AWR YA + STW+ Y R
Sbjct: 323 QHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYER 365
>gi|26051264 potassium voltage-gated channel KQT-like protein 2
isoform a [Homo sapiens]
Length = 872
Score = 345 bits (885), Expect = 8e-95
Identities = 178/343 (51%), Positives = 232/343 (67%), Gaps = 12/343 (3%)
Query: 61 PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTH---VQGRVYNFLERP 117
P P S A S+ R + PR +P +Q +YN LERP
Sbjct: 29 PGAPDSTRDGALLIAGSEAPKRGSILSKPRAGGAGAGKPPKRNAFYRKLQNFLYNVLERP 88
Query: 118 TGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWS 177
GW F+YH VFL+V CL+ SV STI++Y + G L+ +EIV +V FG EY VR+W+
Sbjct: 89 RGW-AFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWA 147
Query: 178 AGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILR 237
AGC +Y G GRL+FARKP +ID++V++AS+ VL GS+G VFATSA+R +RFLQILR
Sbjct: 148 AGCCCRYRGWRGRLKFARKPFCVIDIMVLIASIAVLAAGSQGNVFATSALRSLRFLQILR 207
Query: 238 MLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFG 297
M+ +DR+GGTW+LLGSVV+ H +EL+T YIGFL LI +S+ VYLAEK + F
Sbjct: 208 MIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGFLCLILASFLVYLAEKGEND-----HFD 262
Query: 298 SYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQ 357
+YADALWWG++T+TTIGYGDK PQTW G+ +A+ F++ +SFFALPAGILGSGFALKVQ+
Sbjct: 263 TYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSFFALPAGILGSGFALKVQE 322
Query: 358 KQRQKHFNRQIPAAASLIQTAWRCYA---AENPDSSTWKIYIR 397
+ RQKHF ++ AA LIQ+AWR YA + STW+ Y R
Sbjct: 323 QHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTWQYYER 365
Score = 78.6 bits (192), Expect = 2e-14
Identities = 44/147 (29%), Positives = 88/147 (59%), Gaps = 16/147 (10%)
Query: 486 AEDLDLEGETLLT----PITHISQ-LREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD 540
+E+ L GE ++ P +++ L + +I+ + M++ V+K+KF+++ +PYDV D
Sbjct: 507 SEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMD 566
Query: 541 VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRG--------SNTIGARL 592
VIEQYS GHL+++ RIK LQ R+DQ +G+ ++++K + +G ++ RL
Sbjct: 567 VIEQYSAGHLDMLSRIKSLQSRVDQIVGRGP---AITDKDRTKGPAEAELPEDPSMMGRL 623
Query: 593 NRVEDKVTQLDQRLALITDMLHQLLSL 619
+VE +V ++++L + ++ Q + +
Sbjct: 624 GKVEKQVLSMEKKLDFLVNIYMQRMGI 650
>gi|88758565 potassium voltage-gated channel, shaker-related
subfamily, member 3 [Homo sapiens]
Length = 575
Score = 95.1 bits (235), Expect = 2e-19
Identities = 59/201 (29%), Positives = 101/201 (50%), Gaps = 19/201 (9%)
Query: 157 FWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCV- 215
F +E + +++F E +VR ++ C SK F+R +++ID++ ++ + L
Sbjct: 296 FVVETLCIIWFSFELLVRFFA--CPSKAT-------FSRNIMNLIDIVAIIPYFITLGTE 346
Query: 216 -----GSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGF 270
G+ Q + + +R IR +++ R+ + R ++LG + +EL ++ F
Sbjct: 347 LAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLF 406
Query: 271 LGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIAS 330
+G+I S VY AE D F S DA WW VVT+TT+GYGD P T GK + S
Sbjct: 407 IGVILFSSAVYFAEADDPTSG----FSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGS 462
Query: 331 CFSVFAISFFALPAGILGSGF 351
++ + ALP ++ S F
Sbjct: 463 LCAIAGVLTIALPVPVIVSNF 483
>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
member 2 [Homo sapiens]
Length = 630
Score = 93.6 bits (231), Expect = 5e-19
Identities = 77/286 (26%), Positives = 126/286 (44%), Gaps = 35/286 (12%)
Query: 109 RVYNFLERP-TGWKCFVYHFAVFLIVLVCLIFSVLSTI---------------EQYAALA 152
RV+ E P T V+++ + V +I +V+ T+ E+YA
Sbjct: 170 RVWRAFENPHTSTMALVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAV-- 227
Query: 153 TGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVV 212
F ++ V+ F EY++RL +A R RF R +SIID++ ++ +
Sbjct: 228 --AFFCLDTACVMIFTVEYLLRLAAAP---------SRYRFVRSVMSIIDVVAILPYYIG 276
Query: 213 LCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLG 272
L + V + A +R ++ R+ R R+LG + EL L+ +
Sbjct: 277 LVMTDNEDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMA 334
Query: 273 LIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCF 332
+I + ++ AEK S +F S A W+ +VT+TT+GYGD VP+T GK S
Sbjct: 335 IIIFATVMFYAEKG----SSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSIC 390
Query: 333 SVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTA 378
S+ + ALP ++ S F+ Q QR Q A + I+ A
Sbjct: 391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAA 436
>gi|4826782 potassium voltage-gated channel, shaker-related
subfamily, member 2 [Homo sapiens]
Length = 499
Score = 93.2 bits (230), Expect = 7e-19
Identities = 65/214 (30%), Positives = 107/214 (50%), Gaps = 22/214 (10%)
Query: 147 QYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVV 206
Q + T F +E + +++F E++VR ++ C SK F ++IID++ +
Sbjct: 213 QQSTSFTDPFFIVETLCIIWFSFEFLVRFFA--CPSK-------AGFFTNIMNIIDIVAI 263
Query: 207 VASMVVLCV--------GSKGQVFATSAI-RGIRFLQILRMLHVDRQGGTWRLLGSVVFI 257
+ + L +GQ + AI R IR +++ R+ + R ++LG +
Sbjct: 264 IPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 323
Query: 258 HRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGD 317
+EL ++ F+G+I S VY AE D ES +F S DA WW VV++TT+GYGD
Sbjct: 324 SMRELGLLIFFLFIGVILFSSAVYFAEADE-RES---QFPSIPDAFWWAVVSMTTVGYGD 379
Query: 318 KVPQTWVGKTIASCFSVFAISFFALPAGILGSGF 351
VP T GK + S ++ + ALP ++ S F
Sbjct: 380 MVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 413
>gi|4504817 potassium voltage-gated channel, shaker-related
subfamily, member 4 [Homo sapiens]
Length = 653
Score = 92.4 bits (228), Expect = 1e-18
Identities = 61/205 (29%), Positives = 102/205 (49%), Gaps = 23/205 (11%)
Query: 157 FWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCV- 215
F +E V +V+F E+VVR ++ C S+ + F + ++IID++ ++ + L
Sbjct: 372 FIVETVCIVWFSFEFVVRCFA--CPSQAL-------FFKNIMNIIDIVSILPYFITLGTD 422
Query: 216 ---------GSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTL 266
G + Q + + +R IR +++ R+ + R ++LG + +EL +
Sbjct: 423 LAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLI 482
Query: 267 YIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGK 326
+ F+G+I S VY AE D F S DA WW VVT+TT+GYGD P T GK
Sbjct: 483 FFLFIGVILFSSAVYFAEADEPT----THFQSIPDAFWWAVVTMTTVGYGDMKPITVGGK 538
Query: 327 TIASCFSVFAISFFALPAGILGSGF 351
+ S ++ + ALP ++ S F
Sbjct: 539 IVGSLCAIAGVLTIALPVPVIVSNF 563
>gi|27436981 potassium voltage-gated channel, Shal-related
subfamily, member 1 [Homo sapiens]
Length = 647
Score = 92.0 bits (227), Expect = 2e-18
Identities = 71/272 (26%), Positives = 122/272 (44%), Gaps = 28/272 (10%)
Query: 102 ARTHVQGRVYNFLERP-TGWKCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGT----- 155
A + ++ R++ E P T V+++ + V +I +V+ TI + +
Sbjct: 164 AGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPC 223
Query: 156 -------LFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVA 208
F M+ V+ F EY++RL++A R RF R +S+ID++ ++
Sbjct: 224 GERFPQAFFCMDTACVLIFTGEYLLRLFAAP---------SRCRFLRSVMSLIDVVAILP 274
Query: 209 SMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYI 268
+ L V V + A +R ++ R+ R R+LG + EL L+
Sbjct: 275 YYIGLLVPKNDDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFS 332
Query: 269 GFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTI 328
+ +I + ++ AEK + + F S A W+ +VT+TT+GYGD VP T GK
Sbjct: 333 LTMAIIIFATVMFYAEKG----TNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIF 388
Query: 329 ASCFSVFAISFFALPAGILGSGFALKVQQKQR 360
S S+ + ALP ++ S F+ Q QR
Sbjct: 389 GSICSLSGVLVIALPVPVIVSNFSRIYHQNQR 420
>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
isoform c [Homo sapiens]
Length = 626
Score = 92.0 bits (227), Expect = 2e-18
Identities = 76/314 (24%), Positives = 143/314 (45%), Gaps = 39/314 (12%)
Query: 156 LFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCV 215
L ++E V V++F E++VR+ V L F + ++IID + ++ + + +
Sbjct: 281 LTYIEGVCVLWFTLEFLVRI---------VCCPDTLDFVKNLLNIIDFVAILPFYLEVGL 331
Query: 216 G---SKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLG 272
SK +R +RF++ILR+ + R R+LG + E + + LG
Sbjct: 332 SGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 391
Query: 273 LIFSSYFVYLAEKDAVNESG-----RVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKT 327
++ + +Y AE+ S +F + WW VVT+TT+GYGD P+TW G
Sbjct: 392 VLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGML 451
Query: 328 IASCFSVFAISFFALPAGIL----GSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYA 383
+ + ++ + A+P ++ G ++L + +++ K + +P A L ++ C +
Sbjct: 452 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQL-ESPMYCKS 510
Query: 384 AENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKD---NGVTPGEK--ML 438
E +PR T SP ++ ++++K+ ++ N V E+ L
Sbjct: 511 EET------------SPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGL 558
Query: 439 TVPHITCDPPEERR 452
T P + PEERR
Sbjct: 559 TQPLASSPTPEERR 572
>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
isoform a [Homo sapiens]
Length = 635
Score = 92.0 bits (227), Expect = 2e-18
Identities = 76/314 (24%), Positives = 143/314 (45%), Gaps = 39/314 (12%)
Query: 156 LFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCV 215
L ++E V V++F E++VR+ V L F + ++IID + ++ + + +
Sbjct: 281 LTYIEGVCVLWFTLEFLVRI---------VCCPDTLDFVKNLLNIIDFVAILPFYLEVGL 331
Query: 216 G---SKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLG 272
SK +R +RF++ILR+ + R R+LG + E + + LG
Sbjct: 332 SGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALG 391
Query: 273 LIFSSYFVYLAEKDAVNESG-----RVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKT 327
++ + +Y AE+ S +F + WW VVT+TT+GYGD P+TW G
Sbjct: 392 VLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGML 451
Query: 328 IASCFSVFAISFFALPAGIL----GSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYA 383
+ + ++ + A+P ++ G ++L + +++ K + +P A L ++ C +
Sbjct: 452 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQL-ESPMYCKS 510
Query: 384 AENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKKKKFKLDKD---NGVTPGEK--ML 438
E +PR T SP ++ ++++K+ ++ N V E+ L
Sbjct: 511 EET------------SPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGL 558
Query: 439 TVPHITCDPPEERR 452
T P + PEERR
Sbjct: 559 TQPLASSPTPEERR 572
>gi|119395748 potassium voltage-gated channel subfamily A member 1
[Homo sapiens]
Length = 495
Score = 91.7 bits (226), Expect = 2e-18
Identities = 62/217 (28%), Positives = 105/217 (48%), Gaps = 21/217 (9%)
Query: 143 STIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIID 202
+T+ + + T F +E + +++F E VVR ++ C SK F + ++ ID
Sbjct: 208 TTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFA--CPSK-------TDFFKNIMNFID 258
Query: 203 LIVVVASMVVLCV-------GSKGQVFATSAI-RGIRFLQILRMLHVDRQGGTWRLLGSV 254
++ ++ + L KG+ + AI R IR +++ R+ + R ++LG
Sbjct: 259 IVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQT 318
Query: 255 VFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIG 314
+ +EL ++ F+G+I S VY AE E F S DA WW VV++TT+G
Sbjct: 319 LKASMRELGLLIFFLFIGVILFSSAVYFAEA----EEAESHFSSIPDAFWWAVVSMTTVG 374
Query: 315 YGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGF 351
YGD P T GK + S ++ + ALP ++ S F
Sbjct: 375 YGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNF 411
>gi|27436984 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 1 [Homo sapiens]
Length = 655
Score = 90.5 bits (223), Expect = 5e-18
Identities = 74/287 (25%), Positives = 127/287 (44%), Gaps = 43/287 (14%)
Query: 116 RPTGWKCF----------VYHFAVFLIVLVCLIFSVLSTI--------------EQYAAL 151
R T W+ F V+++ + V +I +V+ T+ E+Y+
Sbjct: 166 RQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSV- 224
Query: 152 ATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV 211
F ++ V+ F EY++RL++A R RF R +SIID++ ++ +
Sbjct: 225 ---AFFCLDTACVMIFTVEYLLRLFAAP---------SRYRFIRSVMSIIDVVAIMPYYI 272
Query: 212 VLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 271
L + + V + A +R ++ R+ R R+LG + EL L+ +
Sbjct: 273 GLVMTNNEDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTM 330
Query: 272 GLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASC 331
+I + ++ AEK S +F S + W+ +VT+TT+GYGD VP+T GK S
Sbjct: 331 AIIIFATVMFYAEKG----SSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSI 386
Query: 332 FSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTA 378
S+ + ALP ++ S F+ Q QR Q A + I+ A
Sbjct: 387 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVA 433
>gi|27436986 potassium voltage-gated channel, Shal-related
subfamily, member 3 isoform 2 [Homo sapiens]
Length = 636
Score = 90.5 bits (223), Expect = 5e-18
Identities = 74/287 (25%), Positives = 127/287 (44%), Gaps = 43/287 (14%)
Query: 116 RPTGWKCF----------VYHFAVFLIVLVCLIFSVLSTI--------------EQYAAL 151
R T W+ F V+++ + V +I +V+ T+ E+Y+
Sbjct: 166 RQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSV- 224
Query: 152 ATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV 211
F ++ V+ F EY++RL++A R RF R +SIID++ ++ +
Sbjct: 225 ---AFFCLDTACVMIFTVEYLLRLFAAP---------SRYRFIRSVMSIIDVVAIMPYYI 272
Query: 212 VLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFL 271
L + + V + A +R ++ R+ R R+LG + EL L+ +
Sbjct: 273 GLVMTNNEDV--SGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTM 330
Query: 272 GLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASC 331
+I + ++ AEK S +F S + W+ +VT+TT+GYGD VP+T GK S
Sbjct: 331 AIIIFATVMFYAEKG----SSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSI 386
Query: 332 FSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTA 378
S+ + ALP ++ S F+ Q QR Q A + I+ A
Sbjct: 387 CSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVA 433
>gi|4504821 potassium voltage-gated channel, shaker-related
subfamily, member 6 [Homo sapiens]
Length = 529
Score = 90.1 bits (222), Expect = 6e-18
Identities = 70/228 (30%), Positives = 106/228 (46%), Gaps = 31/228 (13%)
Query: 140 SVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPIS 199
S LST+ + T F +E + +V+F E +VR + C SK F R ++
Sbjct: 249 SSLSTLG--GSFFTDPFFLVETLCIVWFTFELLVRF--SACPSKPA-------FFRNIMN 297
Query: 200 IIDLIVVVASMVVLCV---------------GSKGQVFATSAI-RGIRFLQILRMLHVDR 243
IIDL+ + + L G GQ + AI R IR +++ R+ + R
Sbjct: 298 IIDLVAIFPYFITLGTELVQQQEQQPASGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSR 357
Query: 244 QGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADAL 303
++LG + +EL ++ F+G+I S VY AE D + F S DA
Sbjct: 358 HSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDDDSL----FPSIPDAF 413
Query: 304 WWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGF 351
WW VVT+TT+GYGD P T GK + S ++ + ALP ++ S F
Sbjct: 414 WWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNF 461
>gi|25952087 potassium voltage-gated channel, shaker-related
subfamily, member 5 [Homo sapiens]
Length = 613
Score = 89.4 bits (220), Expect = 1e-17
Identities = 64/208 (30%), Positives = 100/208 (48%), Gaps = 26/208 (12%)
Query: 157 FWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCV- 215
F +E V++F E +VR ++ C SK F+R ++IID++ + + L
Sbjct: 325 FIVETTCVIWFTFELLVRFFA--CPSK-------AGFSRNIMNIIDVVAIFPYFITLGTE 375
Query: 216 -----------GSKGQVFATSAI-RGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELI 263
G GQ + AI R IR +++ R+ + R ++LG + +EL
Sbjct: 376 LAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELG 435
Query: 264 TTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTW 323
++ F+G+I S VY AE D + F S DA WW VVT+TT+GYGD P T
Sbjct: 436 LLIFFLFIGVILFSSAVYFAEAD----NQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITV 491
Query: 324 VGKTIASCFSVFAISFFALPAGILGSGF 351
GK + S ++ + ALP ++ S F
Sbjct: 492 GGKIVGSLCAIAGVLTIALPVPVIVSNF 519
>gi|25952092 potassium voltage-gated channel, shaker-related
subfamily, member 7 [Homo sapiens]
Length = 456
Score = 89.0 bits (219), Expect = 1e-17
Identities = 57/202 (28%), Positives = 100/202 (49%), Gaps = 19/202 (9%)
Query: 157 FWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCV- 215
F +E + + +F E +VRL C SK + F + +++ID + ++ V L
Sbjct: 210 FVVETLCICWFSFELLVRLLV--CPSKAI-------FFKNVMNLIDFVAILPYFVALGTE 260
Query: 216 -----GSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGF 270
G Q + + +R IR +++ R+ + R ++LG + +EL ++ F
Sbjct: 261 LARQRGVGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLF 320
Query: 271 LGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIAS 330
+G++ S VY AE D V+ F S ++ WW VVT+TT+GYGD P T GK + S
Sbjct: 321 IGVVLFSSAVYFAEVDRVDS----HFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGS 376
Query: 331 CFSVFAISFFALPAGILGSGFA 352
++ + +LP ++ S F+
Sbjct: 377 LCAIAGVLTISLPVPVIVSNFS 398
>gi|27436974 potassium voltage-gated channel, Shab-related
subfamily, member 2 [Homo sapiens]
Length = 911
Score = 88.2 bits (217), Expect = 2e-17
Identities = 68/273 (24%), Positives = 128/273 (46%), Gaps = 38/273 (13%)
Query: 109 RVYNFLERPTGWKCFVYHFAVFLIVLVCLIFSVLSTI-------------EQYAALATGT 155
++++ LE+P A ++ +V ++F VLSTI +++ L
Sbjct: 178 KLWDLLEKPNS------SVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNR 231
Query: 156 -LFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIIDLIVVVASMV-VL 213
L +E V + +F EY++R S+ + +F + P+++IDL+ ++ V +
Sbjct: 232 QLAHVEAVCIAWFTMEYLLRFLSSP---------NKWKFFKGPLNVIDLLAILPYYVTIF 282
Query: 214 CVGSKGQVFATSAIRGI----RFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIG 269
S V +R + R ++ILR+L + R + LG + EL +
Sbjct: 283 LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFL 342
Query: 270 FLGLIFSSYFVYLAEKDAVNESGRVEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIA 329
+G++ S V+ AEKD +F S + WW +T+TT+GYGD P+T +GK +
Sbjct: 343 AMGIMIFSSLVFFAEKD----EDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVG 398
Query: 330 SCFSVFAISFFALPAGILGSGFALKVQQKQRQK 362
+ + ALP I+ + F+ ++++RQ+
Sbjct: 399 GLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQE 431
>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
isoform KV3.2a [Homo sapiens]
Length = 613
Score = 87.4 bits (215), Expect = 4e-17
Identities = 61/241 (25%), Positives = 114/241 (47%), Gaps = 21/241 (8%)
Query: 143 STIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGLWGRLRFARKPISIID 202
S + QY L ++E V VV+F E++VR+ V +L F + ++IID
Sbjct: 269 SVVLQYEIETDPALTYVEGVCVVWFTFEFLVRI---------VFSPNKLEFIKNLLNIID 319
Query: 203 LIVVVASMVVLCVG---SKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHR 259
+ ++ + + + SK +R +RF++ILR+ + R R+LG +
Sbjct: 320 FVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRAST 379
Query: 260 QELITTLYIGFLGLIFSSYFVYLAEKDAV-----NESGRVEFGSYADALWWGVVTVTTIG 314
E + + LG++ + +Y AE+ + S +F + WW VVT+TT+G
Sbjct: 380 NEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLG 439
Query: 315 YGDKVPQTWVGKTIASCFSVFAISFFALPAGIL----GSGFALKVQQKQRQKHFNRQIPA 370
YGD PQTW G + + ++ + A+P ++ G ++L + +++ + + IP
Sbjct: 440 YGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPP 499
Query: 371 A 371
A
Sbjct: 500 A 500
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,751,453
Number of Sequences: 37866
Number of extensions: 1513421
Number of successful extensions: 19024
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 525
Number of HSP's that attempted gapping in prelim test: 13241
Number of HSP's gapped (non-prelim): 5222
length of query: 676
length of database: 18,247,518
effective HSP length: 109
effective length of query: 567
effective length of database: 14,120,124
effective search space: 8006110308
effective search space used: 8006110308
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.