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Search of human proteins with 32455246
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32455246 beta isoform of regulatory subunit A, protein
phosphatase 2 isoform a [Homo sapiens]
(601 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32455246 beta isoform of regulatory subunit A, protein phosph... 1165 0.0
gi|32455244 beta isoform of regulatory subunit A, protein phosph... 1160 0.0
gi|21361399 alpha isoform of regulatory subunit A, protein phosp... 1001 0.0
gi|17402886 HEAT-like repeat-containing protein isoform 1 [Homo ... 65 1e-10
gi|4826934 protein phosphatase 4, regulatory subunit 1 isoform b... 65 2e-10
gi|108936953 protein phosphatase 4, regulatory subunit 1 isoform... 65 2e-10
gi|54607053 GCN1 general control of amino-acid synthesis 1-like ... 52 2e-06
gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens] 50 5e-06
gi|157388904 HEAT repeat containing 2 [Homo sapiens] 41 0.004
gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Hom... 40 0.008
gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens] 39 0.018
gi|4826730 FK506 binding protein 12-rapamycin associated protein... 38 0.031
gi|90903231 huntingtin [Homo sapiens] 37 0.052
gi|93102424 hypothetical protein LOC23116 [Homo sapiens] 37 0.052
gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens] 37 0.068
gi|19923142 karyopherin beta 1 [Homo sapiens] 37 0.068
gi|73695475 protein BAP28 [Homo sapiens] 36 0.089
gi|209969838 transportin 2 (importin 3, karyopherin beta 2b) iso... 35 0.15
gi|209969836 transportin 2 (importin 3, karyopherin beta 2b) iso... 35 0.15
gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isof... 35 0.15
gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens] 34 0.44
gi|163644283 proteasome (prosome, macropain) activator subunit 4... 33 0.75
gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens] 32 2.2
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens] 32 2.2
gi|170784850 SCY1-like 3 isoform 2 [Homo sapiens] 31 3.7
gi|170784842 SCY1-like 3 isoform 1 [Homo sapiens] 31 3.7
gi|10864047 epidermal growth factor receptor pathway substrate 1... 31 3.7
gi|109948292 hypothetical protein LOC57614 [Homo sapiens] 31 3.7
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 30 4.9
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 30 4.9
>gi|32455246 beta isoform of regulatory subunit A, protein
phosphatase 2 isoform a [Homo sapiens]
Length = 601
Score = 1165 bits (3013), Expect = 0.0
Identities = 601/601 (100%), Positives = 601/601 (100%)
Query: 1 MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR 60
MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR
Sbjct: 1 MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR 60
Query: 61 SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA 120
SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA
Sbjct: 61 SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA 120
Query: 121 VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ 180
VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ
Sbjct: 121 VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ 180
Query: 181 QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC 240
QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC
Sbjct: 181 QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC 240
Query: 241 VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ 300
VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ
Sbjct: 241 VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ 300
Query: 301 NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV 360
NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV
Sbjct: 301 NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV 360
Query: 361 IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI 420
IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI
Sbjct: 361 IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI 420
Query: 421 VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK 480
VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK
Sbjct: 421 VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK 480
Query: 481 LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM 540
LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM
Sbjct: 481 LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM 540
Query: 541 AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLAL 600
AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLAL
Sbjct: 541 AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLAL 600
Query: 601 A 601
A
Sbjct: 601 A 601
>gi|32455244 beta isoform of regulatory subunit A, protein
phosphatase 2 isoform b [Homo sapiens]
Length = 667
Score = 1160 bits (3002), Expect = 0.0
Identities = 598/599 (99%), Positives = 599/599 (100%)
Query: 1 MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR 60
MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR
Sbjct: 1 MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR 60
Query: 61 SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA 120
SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA
Sbjct: 61 SELLPFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA 120
Query: 121 VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ 180
VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ
Sbjct: 121 VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQ 180
Query: 181 QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC 240
QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC
Sbjct: 181 QFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC 240
Query: 241 VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ 300
VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ
Sbjct: 241 VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ 300
Query: 301 NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV 360
NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV
Sbjct: 301 NLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV 360
Query: 361 IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI 420
IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI
Sbjct: 361 IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI 420
Query: 421 VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK 480
VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK
Sbjct: 421 VELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK 480
Query: 481 LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM 540
LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM
Sbjct: 481 LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKM 540
Query: 541 AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLA 599
AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISV+A
Sbjct: 541 AGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVVA 599
Score = 100 bits (250), Expect = 3e-21
Identities = 93/417 (22%), Positives = 171/417 (41%), Gaps = 16/417 (3%)
Query: 39 LRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDE-DEVLLALAEQLGNFTGLVGGPDF 97
+R + KL A L ++ +SE++P T DE D V L E + L+ D
Sbjct: 193 VRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDL 252
Query: 98 AHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRT 157
++P L A + VR + ++ + P +P + L R
Sbjct: 253 ETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRA 312
Query: 158 SACGLF-----SVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDS 212
+A ++ + +I + L SD V+ A AS + + +L ++
Sbjct: 313 AAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKEN 372
Query: 213 VKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVR 272
++PLF + DE VRL + + +++ L ++P + + AED WRVR
Sbjct: 373 TIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVR 432
Query: 273 YMVADRFSELQKAMGPKI---TLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIED 329
+ + L +G + LN L A+ L D +R AA + + +L + E
Sbjct: 433 LAIIEYMPLLAGQLGVEFFDEKLNSLCMAW---LVDHVYAIREAATNNLMKLVQKFGTEW 489
Query: 330 RETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDEC 389
+ N I+P + + +D N + I LS G+E T + +LP+ L D+
Sbjct: 490 AQ----NTIVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQV 545
Query: 390 PDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQL 446
+VR N+ +L + ++ L + P + +L +D V+ E + ++A +L
Sbjct: 546 ANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVVAQRL 602
Score = 43.9 bits (102), Expect = 4e-04
Identities = 53/262 (20%), Positives = 99/262 (37%), Gaps = 39/262 (14%)
Query: 378 LPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIE 437
+ + + +L++E +RLN I L + +G+ + LLP + + D V LA+ E
Sbjct: 25 IAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDED-EVLLALAE 83
Query: 438 YMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPK 497
+ G +G F L +R+ A +L ++ Q+ + VP
Sbjct: 84 QLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPL 143
Query: 498 VLVMANDPNYLHRMTT--LF--CINALSEACGQEITTK---------------------- 531
V +A+ + R + LF C S A EI +
Sbjct: 144 VKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGE 203
Query: 532 ------------QMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQKL 579
+++P+ +A D+ +VR ++ I +L + L+ V P L++
Sbjct: 204 FAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQA 263
Query: 580 GQDEDMDVKYFAQEAISVLALA 601
+D+ V+Y + S L A
Sbjct: 264 AEDKSWRVRYMVADRFSELQKA 285
>gi|21361399 alpha isoform of regulatory subunit A, protein
phosphatase 2 [Homo sapiens]
Length = 589
Score = 1001 bits (2587), Expect = 0.0
Identities = 507/588 (86%), Positives = 548/588 (93%)
Query: 14 AGGDGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD 73
A DGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD
Sbjct: 2 AAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYD 61
Query: 74 EDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTP 133
EDEVLLALAEQLG FT LVGGP++ HCLLPPLE+LATVEETVVRDKAVESLR IS EH+P
Sbjct: 62 EDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSP 121
Query: 134 VALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMV 193
LEA+FVPLVKRLA GDWFTSRTSACGLFSVCYPR S+AVKAE+RQ FR+LCSDDTPMV
Sbjct: 122 SDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMV 181
Query: 194 RRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLE 253
RRAAASKLGEFAKVLELD+VKSEI+P+F++LASDEQDSVRLLAVEACV+IAQLL Q+DLE
Sbjct: 182 RRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE 241
Query: 254 TLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAA 313
LVMPTLRQAAEDKSWRVRYMVAD+F+ELQKA+GP+IT DL+PAFQNL+KDCEAEVRAA
Sbjct: 242 ALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAA 301
Query: 314 AAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENT 373
A+HKVKE ENL + RE +IM+QILP IKELVSD NQHVKSALASVIMGLS ILGK+NT
Sbjct: 302 ASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNT 361
Query: 374 IEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL 433
IEHLLPLFLAQLKDECP+VRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL
Sbjct: 362 IEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRL 421
Query: 434 AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNT 493
AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAAT+NL KLV+KFG EWA T
Sbjct: 422 AIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHAT 481
Query: 494 IVPKVLVMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVRFNVA 553
I+PKVL M+ DPNYLHRMTTLFCIN LSE CGQ+ITTK MLP VL+MAGD VANVRFNVA
Sbjct: 482 IIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVA 541
Query: 554 KSLQKIGPILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLALA 601
KSLQKIGPILD + LQ EVKP+L+KL QD+D+DVKYFAQEA++VL+LA
Sbjct: 542 KSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA 589
>gi|17402886 HEAT-like repeat-containing protein isoform 1 [Homo
sapiens]
Length = 873
Score = 65.5 bits (158), Expect = 1e-10
Identities = 96/492 (19%), Positives = 195/492 (39%), Gaps = 49/492 (9%)
Query: 142 PLVKRLASGDWFTSRTSACGLFSVCYPRA-SNAVKAEIRQQFRSLCSDDTPMVRRAAASK 200
PLV + SR +C + + ++ +K EI +SLC D VR +
Sbjct: 176 PLVSKAQLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQ 235
Query: 201 LGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTL 260
L A+ + + KS ++P L+ DE SVRL A E V++ + DD ++P +
Sbjct: 236 LENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLV 295
Query: 261 RQAAEDKSWR----VRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAH 316
+ E KS++ + ++ +L + T + + + K C ++ H
Sbjct: 296 KSFCE-KSFKADESILISLSFHLGKLCHGLYGIFTPDQHLRFLEFYKKLCTLGLQQENGH 354
Query: 317 KVKELGENLPIEDRETIIMNQILPY--------------IKELVS-------DTNQHVKS 355
++ + ++++ I + + Y EL S D V+
Sbjct: 355 NENQIPPQILEQEKKYISVRKNCAYNFPAMIVFVDPKNFHMELYSTFFCLCHDPEVPVRY 414
Query: 356 ALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVI------GI 409
+A +S +L + H + L+DE +V +I +L + E++ +
Sbjct: 415 TIAICFYEVSKLLNSGVYLIH--KELITLLQDESLEVLDALIDHLPEILELMSTGGESSV 472
Query: 410 RQLSQSLLPAIV--------ELAEDAKWRVRLAIIEYMPLLAGQLGV-EFFDEKLNSLCM 460
++ S LP ++ A KWR +++ L + + + L +
Sbjct: 473 QENKLSSLPDLIPALTAAEQRAAASLKWRTHEKLLQKYACLPHVISSDQIYYRFLQRMFT 532
Query: 461 AWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVL-VMANDPNYLHRMTTLFCINA 519
+ ++V +++AA+ L ++ + ++ ++ K++ + +Y +R+ L
Sbjct: 533 IMMTNNVLPVQKAASRTLCIFLRYNRKQEQRHEVIQKLIEQLGQGKSYWNRLRFLDTCEF 592
Query: 520 LSEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPIL----DTNALQGEVKPV 575
+ E + K +++ D VANVR + L K+ L D + LQ V
Sbjct: 593 IIEIFSKSFFCKYFFLPAIELTHDPVANVRMKLCYLLPKVKSTLKIPADKHLLQQLEMCV 652
Query: 576 LQKLGQDEDMDV 587
+ L Q++D DV
Sbjct: 653 RKLLCQEKDKDV 664
Score = 42.7 bits (99), Expect = 0.001
Identities = 40/175 (22%), Positives = 74/175 (42%), Gaps = 1/175 (0%)
Query: 404 NEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFF-DEKLNSLCMAW 462
+E + I + S L I+ E V A +E + + L E E LN L
Sbjct: 122 DESVSIHAYTHSFLQVILLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSKA 181
Query: 463 LVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSE 522
+ R + L KL KF + I+P V + D Y R + +++
Sbjct: 182 QLSQTVQSRLVSCKILGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQ 241
Query: 523 ACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTNALQGEVKPVLQ 577
G E+T +LP +++++ D+ ++VR ++L + I DT+ + P+++
Sbjct: 242 GIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDIFDTDDRSQTILPLVK 296
Score = 37.7 bits (86), Expect = 0.031
Identities = 49/197 (24%), Positives = 90/197 (45%), Gaps = 9/197 (4%)
Query: 246 LLSQDDLETL--VMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAF-QNL 302
L+ Q+ ETL V+P +R+A ++ A F L ++++ +F Q +
Sbjct: 81 LMRQNPTETLRRVLPKVREALHVAGVEMQLTAAMSF--LTILQDESVSIHAYTHSFLQVI 138
Query: 303 LKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV-I 361
L E + ++ L + + +ET+ + P + + + +Q V+S L S I
Sbjct: 139 LLHLEHRDTGVSNAWLETLLSVIEVLPKETLRHEILNPLVSK--AQLSQTVQSRLVSCKI 196
Query: 362 MGLSTILGKENTIEH-LLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAI 420
+G T +TI+ +LPL + +D +VR + L+ + + IG +LP +
Sbjct: 197 LGKLTNKFDAHTIKREILPLVKSLCQDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPEL 256
Query: 421 VELAEDAKWRVRLAIIE 437
+EL+ D VRLA E
Sbjct: 257 IELSRDEGSSVRLAAFE 273
Score = 34.3 bits (77), Expect = 0.34
Identities = 68/296 (22%), Positives = 115/296 (38%), Gaps = 31/296 (10%)
Query: 35 EDVQLRLNSI--KKLSTIALALGVERTRSELLPFLTDTIYDE-DEVLLALAEQLGNFTGL 91
+DV+ + S ++L IA +G E T+S +LP L + DE V LA E L N +
Sbjct: 222 QDVEYEVRSCMCRQLENIAQGIGTELTKSVVLPELIELSRDEGSSVRLAAFETLVNLLDI 281
Query: 92 VGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGD 151
D + +LP +++ E++ D+++ L +S + Y + +
Sbjct: 282 FDTDDRSQTILPLVKSFC--EKSFKADESI--LISLSFHLGKLCHGLYGIFTPDQHLRFL 337
Query: 152 WFTSRTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELD 211
F + GL N + +I +Q + S VR+ A ++
Sbjct: 338 EFYKKLCTLGLQQE-NGHNENQIPPQILEQEKKYIS-----VRKNCAYNFPAMIVFVDPK 391
Query: 212 SVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRV 271
+ E+ F L D + VR +++LL+ L+ L +D+S V
Sbjct: 392 NFHMELYSTFFCLCHDPEVPVRYTIAICFYEVSKLLNSG--VYLIHKELITLLQDESLEV 449
Query: 272 RYMVADRFSELQKAM----------GPKITLNDLIPAFQNLLKDCEAEVRAAAAHK 317
+ D E+ + M +L DLIPA AE RAAA+ K
Sbjct: 450 LDALIDHLPEILELMSTGGESSVQENKLSSLPDLIPAL------TAAEQRAAASLK 499
>gi|4826934 protein phosphatase 4, regulatory subunit 1 isoform b
[Homo sapiens]
Length = 933
Score = 65.1 bits (157), Expect = 2e-10
Identities = 66/260 (25%), Positives = 113/260 (43%), Gaps = 14/260 (5%)
Query: 345 LVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVN 404
L SD V+ LA I L+ ILG + T L+P+F LKD +VR+ ++ +L
Sbjct: 654 LASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGVLKHLHDFL 712
Query: 405 EVIGIRQLSQSLLPAIVELAED--AKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAW 462
+++ I + + L L D WR R + E + LL + L + +
Sbjct: 713 KLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNL 772
Query: 463 LVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMAND----PNYLHRMTTLF-CI 517
D V ++R + + ++V+K V + + + P + R +F C
Sbjct: 773 CADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQ 832
Query: 518 NALSEAC-GQEITTKQMLPIVLKMAGDQVANVRFNVAKS-----LQKIGPILDTNALQGE 571
+ + C + ++P +L +A D+V NVR +AK+ L+K + + Q
Sbjct: 833 TVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEA 892
Query: 572 VKPVLQKLGQDEDMDVKYFA 591
V+ + L D D DVKYFA
Sbjct: 893 VEQTIMALQMDRDSDVKYFA 912
Score = 55.5 bits (132), Expect = 1e-07
Identities = 66/303 (21%), Positives = 121/303 (39%), Gaps = 24/303 (7%)
Query: 187 SDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQL 246
S D + K + V ++ + DE+D C+++ +
Sbjct: 23 SQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERD---------CIAVLER 73
Query: 247 LSQ--DDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLK 304
+S+ DD E PT+R ++ + F + + P L+P L
Sbjct: 74 ISRLADDSE----PTVRAELMEQVPHIAL-----FCQENRPSIPYAFSKFLLPIVVRYLA 124
Query: 305 DCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVS-DTNQHVKSALASVIMG 363
D +VR + + L E IE + + ++ P + EL + D+N VK+ +++
Sbjct: 125 DQNNQVRKTSQAALLALLEQELIERFD--VETKVCPVLIELTAPDSNDDVKTEAVAIMCK 182
Query: 364 LSTILGKENTIEHLLPLFLAQLKD-ECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVE 422
++ ++GK+ T +LP F D VR +N + V+G + + LLP +
Sbjct: 183 MAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQ 242
Query: 423 LAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLV 482
L D W VR A E ++ E KL++L + + D +R+AA +L +
Sbjct: 243 LCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFI 302
Query: 483 QKF 485
F
Sbjct: 303 STF 305
Score = 51.6 bits (122), Expect = 2e-06
Identities = 57/231 (24%), Positives = 94/231 (40%), Gaps = 13/231 (5%)
Query: 178 IRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAV 237
+R+ + +L SD VRR A + E A +L +++VP+F D D VR+ +
Sbjct: 647 LRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGVL 705
Query: 238 EACVSIAQLLSQDDLETLVMPTLRQAAEDKS--WRVRYMVADRFSELQKAMGPKITLNDL 295
+ +LL D + D S WR R +A++ L + P+ + L
Sbjct: 706 KHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYL 765
Query: 296 IPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVK- 354
P NL D + VR + V E+ + L T ++ I ELV + + K
Sbjct: 766 RPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVD----LINELVENFGRCPKW 821
Query: 355 SALASVIMGLSTI-----LGKENTIEHLLPLFLAQLKDECPDVRLNIISNL 400
S + + T+ L + HL+P L D P+VR+ + L
Sbjct: 822 SGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL 872
Score = 34.7 bits (78), Expect = 0.26
Identities = 40/178 (22%), Positives = 67/178 (37%), Gaps = 15/178 (8%)
Query: 379 PLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 438
P A+L ++ P + L N + S+ LLP +V D +VR
Sbjct: 83 PTVRAELMEQVPHIALFCQENRPSIPYAF-----SKFLLPIVVRYLADQNNQVRKTSQAA 137
Query: 439 MPLLAGQLGVEFFDEKLNSLCMAWLV----DHVYAIREAATNNLMKLVQKFGTEWAQNTI 494
+ L Q +E FD + +C + D ++ A + K+ G + + I
Sbjct: 138 LLALLEQELIERFDVE-TKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLI 196
Query: 495 VPKVLVMANDPNYLHRMTTLFCINALSEAC---GQEITTKQMLPIVLKMAGDQVANVR 549
+P+ M D H C + C GQ+ T + +LP ++ D V VR
Sbjct: 197 LPRFCEMCCDCRMFH--VRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVR 252
Score = 32.0 bits (71), Expect = 1.7
Identities = 36/174 (20%), Positives = 72/174 (41%), Gaps = 2/174 (1%)
Query: 156 RTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKS 215
+ A +C A + + +F LCSD+ VR+A A + + ++
Sbjct: 214 KVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRT 273
Query: 216 EIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMV 275
++ LF +L SD VR A ++ + +++E+ S +
Sbjct: 274 KLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRT 333
Query: 276 ADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGE-NLPIE 328
D+ + + P+ T +DL + +++ + E AA A K LGE ++P++
Sbjct: 334 RDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEA-SGKPLGEISVPLD 386
>gi|108936953 protein phosphatase 4, regulatory subunit 1 isoform a
[Homo sapiens]
Length = 950
Score = 65.1 bits (157), Expect = 2e-10
Identities = 66/260 (25%), Positives = 113/260 (43%), Gaps = 14/260 (5%)
Query: 345 LVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVN 404
L SD V+ LA I L+ ILG + T L+P+F LKD +VR+ ++ +L
Sbjct: 671 LASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGVLKHLHDFL 729
Query: 405 EVIGIRQLSQSLLPAIVELAED--AKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAW 462
+++ I + + L L D WR R + E + LL + L + +
Sbjct: 730 KLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYLRPIALNL 789
Query: 463 LVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMAND----PNYLHRMTTLF-CI 517
D V ++R + + ++V+K V + + + P + R +F C
Sbjct: 790 CADKVSSVRWISYKLVSEMVKKLHAATPPTFGVDLINELVENFGRCPKWSGRQAFVFVCQ 849
Query: 518 NALSEAC-GQEITTKQMLPIVLKMAGDQVANVRFNVAKS-----LQKIGPILDTNALQGE 571
+ + C + ++P +L +A D+V NVR +AK+ L+K + + Q
Sbjct: 850 TVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTLRQTLLEKDYFLASASCHQEA 909
Query: 572 VKPVLQKLGQDEDMDVKYFA 591
V+ + L D D DVKYFA
Sbjct: 910 VEQTIMALQMDRDSDVKYFA 929
Score = 55.5 bits (132), Expect = 1e-07
Identities = 66/303 (21%), Positives = 121/303 (39%), Gaps = 24/303 (7%)
Query: 187 SDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQL 246
S D + K + V ++ + DE+D C+++ +
Sbjct: 40 SQDEMLTPLGRLDKYAASENIFNRQMVARSLLDTLREVCDDERD---------CIAVLER 90
Query: 247 LSQ--DDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLK 304
+S+ DD E PT+R ++ + F + + P L+P L
Sbjct: 91 ISRLADDSE----PTVRAELMEQVPHIAL-----FCQENRPSIPYAFSKFLLPIVVRYLA 141
Query: 305 DCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVS-DTNQHVKSALASVIMG 363
D +VR + + L E IE + + ++ P + EL + D+N VK+ +++
Sbjct: 142 DQNNQVRKTSQAALLALLEQELIERFD--VETKVCPVLIELTAPDSNDDVKTEAVAIMCK 199
Query: 364 LSTILGKENTIEHLLPLFLAQLKD-ECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVE 422
++ ++GK+ T +LP F D VR +N + V+G + + LLP +
Sbjct: 200 MAPMVGKDITERLILPRFCEMCCDCRMFHVRKVCAANFGDICSVVGQQATEEMLLPRFFQ 259
Query: 423 LAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLV 482
L D W VR A E ++ E KL++L + + D +R+AA +L +
Sbjct: 260 LCSDNVWGVRKACAECFMAVSCATCQEIRRTKLSALFINLISDPSRWVRQAAFQSLGPFI 319
Query: 483 QKF 485
F
Sbjct: 320 STF 322
Score = 51.6 bits (122), Expect = 2e-06
Identities = 57/231 (24%), Positives = 94/231 (40%), Gaps = 13/231 (5%)
Query: 178 IRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAV 237
+R+ + +L SD VRR A + E A +L +++VP+F D D VR+ +
Sbjct: 664 LRETYETLASDMQWKVRRTLAFSIHELAVILGDQLTAADLVPIFNGFLKD-LDEVRIGVL 722
Query: 238 EACVSIAQLLSQDDLETLVMPTLRQAAEDKS--WRVRYMVADRFSELQKAMGPKITLNDL 295
+ +LL D + D S WR R +A++ L + P+ + L
Sbjct: 723 KHLHDFLKLLHIDKRREYLYQLQEFLVTDNSRNWRFRAELAEQLILLLELYSPRDVYDYL 782
Query: 296 IPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVK- 354
P NL D + VR + V E+ + L T ++ I ELV + + K
Sbjct: 783 RPIALNLCADKVSSVRWISYKLVSEMVKKLHAATPPTFGVD----LINELVENFGRCPKW 838
Query: 355 SALASVIMGLSTI-----LGKENTIEHLLPLFLAQLKDECPDVRLNIISNL 400
S + + T+ L + HL+P L D P+VR+ + L
Sbjct: 839 SGRQAFVFVCQTVIEDDCLPMDQFAVHLMPHLLTLANDRVPNVRVLLAKTL 889
Score = 34.7 bits (78), Expect = 0.26
Identities = 40/178 (22%), Positives = 67/178 (37%), Gaps = 15/178 (8%)
Query: 379 PLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 438
P A+L ++ P + L N + S+ LLP +V D +VR
Sbjct: 100 PTVRAELMEQVPHIALFCQENRPSIPYAF-----SKFLLPIVVRYLADQNNQVRKTSQAA 154
Query: 439 MPLLAGQLGVEFFDEKLNSLCMAWLV----DHVYAIREAATNNLMKLVQKFGTEWAQNTI 494
+ L Q +E FD + +C + D ++ A + K+ G + + I
Sbjct: 155 LLALLEQELIERFDVE-TKVCPVLIELTAPDSNDDVKTEAVAIMCKMAPMVGKDITERLI 213
Query: 495 VPKVLVMANDPNYLHRMTTLFCINALSEAC---GQEITTKQMLPIVLKMAGDQVANVR 549
+P+ M D H C + C GQ+ T + +LP ++ D V VR
Sbjct: 214 LPRFCEMCCDCRMFH--VRKVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVR 269
Score = 32.0 bits (71), Expect = 1.7
Identities = 36/174 (20%), Positives = 72/174 (41%), Gaps = 2/174 (1%)
Query: 156 RTSACGLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKS 215
+ A +C A + + +F LCSD+ VR+A A + + ++
Sbjct: 231 KVCAANFGDICSVVGQQATEEMLLPRFFQLCSDNVWGVRKACAECFMAVSCATCQEIRRT 290
Query: 216 EIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMV 275
++ LF +L SD VR A ++ + +++E+ S +
Sbjct: 291 KLSALFINLISDPSRWVRQAAFQSLGPFISTFANPSSSGQYFKEESKSSEEMSVENKNRT 350
Query: 276 ADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGE-NLPIE 328
D+ + + P+ T +DL + +++ + E AA A K LGE ++P++
Sbjct: 351 RDQEAPEDVQVRPEDTPSDLSVSNSSVILENTMEDHAAEA-SGKPLGEISVPLD 403
>gi|54607053 GCN1 general control of amino-acid synthesis 1-like 1
[Homo sapiens]
Length = 2671
Score = 52.0 bits (123), Expect = 2e-06
Identities = 63/352 (17%), Positives = 143/352 (40%), Gaps = 16/352 (4%)
Query: 217 IVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVA 276
++P D VR A + ++ LS ++ LV+P+L A E++SWR +
Sbjct: 1460 VLPHLLLCFGDGNQYVREAADDCAKAVMSNLSAHGVK-LVLPSLLAALEEESWRTKAGSV 1518
Query: 277 DRFSELQKAMGPKIT--LNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETII 334
+ + +++ L +++P +L D +V+ A ++++G I + E +
Sbjct: 1519 ELLGAMAYCAPKQLSSCLPNIVPKLTEVLTDSHVKVQKAGQQALRQIGS--VIRNPEIL- 1575
Query: 335 MNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLPLFLAQLKDECPDVR- 393
I P + + ++D ++ + L +++ ++ ++P+ +D D R
Sbjct: 1576 --AIAPVLLDALTDPSRKTQKCLQTLLDTKFVHFIDAPSLALIMPIVQRAFQDRSTDTRK 1633
Query: 394 --LNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFF 451
II N+ + + + S+ P + D VR + + + +G F
Sbjct: 1634 MAAQIIGNMYSLTDQKDLAPYLPSVTPGLKASLLDPVPEVRTVSAKALGAMVKGMGESCF 1693
Query: 452 DEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRM 511
++ L L + R A L +++ G E + ++P+++ A+ + +
Sbjct: 1694 EDLLPWLMETLTYEQSSVDRSGAAQGLAEVMAGLGVEKLEK-LMPEIVATASKVDIAPHV 1752
Query: 512 TT--LFCINALSEACGQEIT--TKQMLPIVLKMAGDQVANVRFNVAKSLQKI 559
+ N L G + T ++P +LK D+ VR ++ Q++
Sbjct: 1753 RDGYIMMFNYLPITFGDKFTPYVGPIIPCILKALADENEFVRDTALRAGQRV 1804
Score = 48.9 bits (115), Expect = 1e-05
Identities = 80/350 (22%), Positives = 135/350 (38%), Gaps = 52/350 (14%)
Query: 217 IVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVA 276
I+P +DE + VR A+ A + + ++ + L++P L Q D WR+
Sbjct: 1778 IIPCILKALADENEFVRDTALRAGQRVISMYAETAI-ALLLPQLEQGLFDDLWRI----- 1831
Query: 277 DRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRA-----AAAHKVKELGENLPIEDRE 331
RFS +Q L DL+ + E + A K + L +E R
Sbjct: 1832 -RFSSVQ-------LLGDLLFHISGVTGKMTTETASEDDNFGTAQSNKAIITALGVERR- 1882
Query: 332 TIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEHLLP----LFLAQLKD 387
N++L + SDT V+ AS+ + + T+ +LP L L L
Sbjct: 1883 ----NRVLAGLYMGRSDTQLVVRQ--ASLHVWKIVVSNTPRTLREILPTLFGLLLGFLAS 1936
Query: 388 ECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAE--------DAKWRVRLAIIEYM 439
C D R L + +R+L + +LP I+ + E D + V + + E M
Sbjct: 1937 TCADKRTIAARTLGDL-----VRKLGEKILPEIIPILEEGLRSQKSDERQGVCIGLSEIM 1991
Query: 440 PLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVL 499
+ V +F E L L D + +REAA +L G + A I+P +L
Sbjct: 1992 KSTSRD-AVLYFSESLVPTARKALCDPLEEVREAAAKTFEQLHSTIGHQ-ALEDILPFLL 2049
Query: 500 VMANDPNYLHRMTTLFCINALSEACGQEITTKQMLPIVLKMAGDQVANVR 549
+D + F ++ L + I ++ +LP ++ N R
Sbjct: 2050 KQLDDEE-----VSEFALDGLKQV--MAIKSRVVLPYLVPKLTTPPVNTR 2092
Score = 42.0 bits (97), Expect = 0.002
Identities = 120/526 (22%), Positives = 209/526 (39%), Gaps = 84/526 (15%)
Query: 14 AGGDGDDSLY-----PIAVLIDELRNEDVQLRLNSIKKLSTIALALGV----ERTRSELL 64
A GDD + VL+ L++ +R ++ L + + L E+ LL
Sbjct: 1068 ASSSGDDGCAFAEQEEVDVLLCALQSPCASVRETVLRGLMELHMVLPAPDTDEKNGLNLL 1127
Query: 65 PFLTDTIYDEDEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESL 124
L +D++E + LAE+L + GL PD L+ + E VR E+L
Sbjct: 1128 RRLWVVKFDKEEEIRKLAERLWSMMGLDLQPDLCSLLIDDV----IYHEAAVRQAGAEAL 1183
Query: 125 RQISQEHTPVALEA------------YFVPLV----KRLASGDWFTSRTSACGLFSVCYP 168
Q + A E Y P V R+ S + CGL
Sbjct: 1184 SQAVARYQRQAAEVMGRLMEIYQEKLYRPPPVLDALGRVISESPPDQWEARCGLALALNK 1243
Query: 169 RASNAVKAEIRQQFR----SLCSDDTPMVRR----AAASKLGEFAKVLELDSVKSEIVPL 220
+ ++++ F+ +D P VR+ AA + L K ++V S ++P+
Sbjct: 1244 LSQYLDSSQVKPLFQFFVPDALNDRHPDVRKCMLDAALATLNTHGK----ENVNS-LLPV 1298
Query: 221 FTSLASD-----EQDSVRLLAVEACVSIAQLLSQDDLETL-VMPTLRQAAEDKSWRVRYM 274
F + D+VR V S+A+ L + D + ++ L A S +V+
Sbjct: 1299 FEEFLKNAPNDASYDAVRQSVVVLMGSLAKHLDKSDPKVKPIVAKLIAALSTPSQQVQES 1358
Query: 275 VADRFSELQKAMGPKITLNDLIP-AFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETI 333
VA L A+ K +I Q LL+ + R AA+ + L + L I ++
Sbjct: 1359 VASCLPPLVPAI--KEDAGGMIQRLMQQLLESDKYAERKGAAYGLAGLVKGLGI---LSL 1413
Query: 334 IMNQILPYIKELVSDTN--QHVKSALASVIMGLSTILGK--ENTIEHLLPLFL------- 382
+++ + + + D + + AL + M L T+LGK E + H+LP L
Sbjct: 1414 KQQEMMAALTDAIQDKKNFRRREGALFAFEM-LCTMLGKLFEPYVVHVLPHLLLCFGDGN 1472
Query: 383 AQLKDECPDVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLL 442
+++ D ++SNL G++ + SLL A+ E+ WR + +E + +
Sbjct: 1473 QYVREAADDCAKAVMSNL----SAHGVKLVLPSLLAAL----EEESWRTKAGSVELLGAM 1524
Query: 443 AGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTE 488
A + K S C+ +V + E T++ +K VQK G +
Sbjct: 1525 A------YCAPKQLSSCLPNIVP---KLTEVLTDSHVK-VQKAGQQ 1560
>gi|54112117 splicing factor 3b, subunit 1 isoform 1 [Homo sapiens]
Length = 1304
Score = 50.4 bits (119), Expect = 5e-06
Identities = 120/617 (19%), Positives = 251/617 (40%), Gaps = 70/617 (11%)
Query: 25 IAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFL-----TDTIYDEDEVLL 79
I+ + ++ N D +R + + + +A ALG+ LLPFL + + +
Sbjct: 610 ISTMRPDIDNMDEYVRNTTARAFAVVASALGIP----SLLPFLKAVCKSKKSWQARHTGI 665
Query: 80 ALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAY 139
+ +Q+ G P L+ +E+ E+ VR + ++ +++ TP +E++
Sbjct: 666 KIVQQIAILMGCAILPHL-RSLVEIIEHGLVDEQQKVRTISALAIAALAEAATPYGIESF 724
Query: 140 ---FVPLVK--RLASGDWFTSRTSACG-LFSVCYPRASNAVKAEIR----QQFRSLCSDD 189
PL K R G + A G L + +N E+ ++F+S +
Sbjct: 725 DSVLKPLWKGIRQHRGKGLAAFLKAIGYLIPLMDAEYANYYTREVMLILIREFQSPDEEM 784
Query: 190 TPMVRRAAASKLGEFAKVLELDSVKSEIVPLFTS------LASDEQDSVRLLAVEACVSI 243
+V + G +E + +K+EI+P F +A D ++ +L V+ V +
Sbjct: 785 KKIVLKVVKQCCGTDG--VEANYIKTEILPPFFKHFWQHRMALDRRNYRQL--VDTTVEL 840
Query: 244 AQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGP--------KITLNDL 295
A + ++ + ++ L+ AE + R MV + ++ +G + ++ +
Sbjct: 841 ANKVGAAEIISRIVDDLKDEAE----QYRKMVMETIEKIMGNLGAADIDHKLEEQLIDGI 896
Query: 296 IPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKS 355
+ AFQ + + V LG+ R + QI + +++ + V+
Sbjct: 897 LYAFQEQTTEDSVMLNGFGT-VVNALGK------RVKPYLPQICGTVLWRLNNKSAKVRQ 949
Query: 356 ALASVIMGLSTILG---KENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIRQL 412
A +I + ++ +E + HL + L +E P+V +I+ L + VIG+ ++
Sbjct: 950 QAADLISRTAVVMKTCQEEKLMGHLGVVLYEYLGEEYPEVLGSILGALKAIVNVIGMHKM 1009
Query: 413 S---QSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFD-EKLNSLC---MAWLVD 465
+ + LLP + + ++ +V+ I+ + +A + G E+ + +C + L
Sbjct: 1010 TPPIKDLLPRLTPILKNRHEKVQENCIDLVGRIADR-GAEYVSAREWMRICFELLELLKA 1068
Query: 466 HVYAIREAATNNLMKLVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINALSEACG 525
H AIR A N + + G T++ + V +R+ T I ++E C
Sbjct: 1069 HKKAIRRATVNTFGYIAKAIGPHDVLATLLNNLKVQERQ----NRVCTTVAIAIVAETC- 1123
Query: 526 QEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIGPILDTNALQ--GEVKPVLQKLGQDE 583
+ +LP ++ NV+ V KSL + + V P+L+ D
Sbjct: 1124 ---SPFTVLPALMNEYRVPELNVQNGVLKSLSFLFEYIGEMGKDYIYAVTPLLEDALMDR 1180
Query: 584 DMDVKYFAQEAISVLAL 600
D+ + A + ++L
Sbjct: 1181 DLVHRQTASAVVQHMSL 1197
>gi|157388904 HEAT repeat containing 2 [Homo sapiens]
Length = 855
Score = 40.8 bits (94), Expect = 0.004
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 17/192 (8%)
Query: 75 DEVLLALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRD----------KAVESL 124
+E+ LAL + LG L G L P L++ + D +L
Sbjct: 139 EELRLALVQLLGLAVDLCGA-----ALAPHLDDALRALRCSLLDPFAAVRRESCSCAAAL 193
Query: 125 RQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAEIRQQFRS 184
Q + +H + E+ PL++ ++ W R +A + ++ F
Sbjct: 194 AQATPDHFHMQSESLIGPLMQTISHQHWKV-RVAAIEATGAVIHFGNGKSVDDVLSHFAQ 252
Query: 185 LCSDDTPMVRRAAASKLGEFAKVL-ELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSI 243
DD P VRRA AS +G + L + S +++PL S +DE VR LA +
Sbjct: 253 RLFDDVPQVRRAVASVVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVPEVRQLAASLWEDV 312
Query: 244 AQLLSQDDLETL 255
+++ E L
Sbjct: 313 GLQWQKENEEDL 324
Score = 34.7 bits (78), Expect = 0.26
Identities = 20/60 (33%), Positives = 33/60 (55%), Gaps = 1/60 (1%)
Query: 335 MNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKENTIEH-LLPLFLAQLKDECPDVR 393
++ +L + + + D V+ A+ASV+ G L + H L+PL L+ L DE P+VR
Sbjct: 243 VDDVLSHFAQRLFDDVPQVRRAVASVVGGWLLCLRDRYSFFHKLIPLLLSSLNDEVPEVR 302
>gi|23943912 phosphoinositide-3-kinase, regulatory subunit 4 [Homo
sapiens]
Length = 1358
Score = 39.7 bits (91), Expect = 0.008
Identities = 39/146 (26%), Positives = 61/146 (41%), Gaps = 9/146 (6%)
Query: 304 KDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMG 363
KD + H + E E P E+ I+++ I ++ L + K A +I+
Sbjct: 348 KDLGNIIHNLCGHDLPEKAEGEPKENGLVILVSVITSCLQTLKYCDS---KLAALELILH 404
Query: 364 LSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCVNEVI------GIRQLSQSLL 417
L+ L E ++ + P L D P VR + L V ++ I + +L
Sbjct: 405 LAPRLSVEILLDRITPYLLHFSNDSVPRVRAEALRTLTKVLALVKEVPRNDINIYPEYIL 464
Query: 418 PAIVELAEDAKWRVRLAIIEYMPLLA 443
P I LA+D VRLA E + LLA
Sbjct: 465 PGIAHLAQDDATIVRLAYAENIALLA 490
>gi|241982712 TBP-interacting protein isoform 1 [Homo sapiens]
Length = 1236
Score = 38.5 bits (88), Expect = 0.018
Identities = 100/458 (21%), Positives = 172/458 (37%), Gaps = 67/458 (14%)
Query: 18 GDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIA---LALGVERTRSELLPFLTDTIYDE 74
GDD + +L+D LRNE RL +IK L+ +A L L ++ +E L L +
Sbjct: 607 GDDLEPTLLLLLDRLRNEIT--RLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKN 664
Query: 75 DEVL----LALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQE 130
L LA + L GL P +L L L + V AV+ L ++Q
Sbjct: 665 QRALRLATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQA 724
Query: 131 HTPVALEAYFVPLVKR--------------LASGDWFTSRTSACGLFSVCYPRASNAVKA 176
P +L P++ LA+ + F V Y + + + A
Sbjct: 725 Q-PASLVEVSGPVLSELLRLLRSPLLPAGVLAAAEGFLQALVGTRPPCVDYAKLISLLTA 783
Query: 177 EIRQQFRSLCSDDTPMVRRAAASKLGEFAKVL------ELDSVKSEIVPLFTSLASDEQD 230
+ +Q D P + + L L E S S +V + +
Sbjct: 784 PVYEQ----AVDGGPGLHKQVFHSLARCVAALSAACPQEAASTASRLV--CDARSPHSST 837
Query: 231 SVRLLAVEACVSIAQLLS---QDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMG 287
V++LA + + Q+ Q +L+ +++ L +ED Y + + G
Sbjct: 838 GVKVLAFLSLAEVGQVAGPGHQRELKAVLLEALGSPSEDVRAAASYALG------RVGAG 891
Query: 288 PKITLNDLIPAFQNLLKDCEAEVRA--AAAHKVKE-LGENLPIEDRETIIMNQILPYIKE 344
+L D +P LL+ EAE R H ++E LG P + + PY ++
Sbjct: 892 ---SLPDFLPF---LLEQIEAEPRRQYLLLHSLREALGAAQP---------DSLKPYAED 936
Query: 345 LVSDTNQHVKSALASVIMGLSTILGKENTI--EHLLPLFLAQLKDECPDVRLNIISNLDC 402
+ + Q + A ++ +GK + LLP QL P R +I+ +
Sbjct: 937 IWALLFQRCEGAEEGTRGVVAECIGKLVLVNPSFLLPRLRKQLAAGRPHTRSTVITAVKF 996
Query: 403 V--NEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEY 438
+ ++ I L +S + +E +D VR A + +
Sbjct: 997 LISDQPHPIDPLLKSFIGEFMESLQDPDLNVRRATLAF 1034
>gi|4826730 FK506 binding protein 12-rapamycin associated protein 1
[Homo sapiens]
Length = 2549
Score = 37.7 bits (86), Expect = 0.031
Identities = 62/286 (21%), Positives = 116/286 (40%), Gaps = 34/286 (11%)
Query: 223 SLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRY-MVADRFSE 281
S + QDS E V++ L + + M L + D+S + MV +
Sbjct: 918 SESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITF 977
Query: 282 LQKAMGPKIT--LNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQIL 339
+ K++G K L ++P F N+++ C+ +R ++ L + + + I
Sbjct: 978 IFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGML---------VSFVKSHIR 1028
Query: 340 PYIKELVS------DTNQHVKSALASVIMGLSTILGKE------NTIEHLLPLFLAQLKD 387
PY+ E+V+ N ++S + +I + LG E I H+L +F + D
Sbjct: 1029 PYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVF---MHD 1085
Query: 388 ECPD--VRLNIISNLDCVNEVIGIRQLSQSLLPAIVEL--AEDAKWRVRLAIIEYMPLLA 443
P V + +++ + + LLP IV+L A +A R A +E + L
Sbjct: 1086 NSPGRIVSIKLLAAIQLFG--ANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLT 1143
Query: 444 GQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMKLVQKFGTEW 489
L + ++ + L D +R A + L LV + G ++
Sbjct: 1144 ESLDFTDYASRIIHPIVRTL-DQSPELRSTAMDTLSSLVFQLGKKY 1188
>gi|90903231 huntingtin [Homo sapiens]
Length = 3144
Score = 37.0 bits (84), Expect = 0.052
Identities = 49/218 (22%), Positives = 87/218 (39%), Gaps = 39/218 (17%)
Query: 203 EFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQ 262
EF K+L + + LF + D + VR++A E + + L +L L + ++
Sbjct: 122 EFQKLLGI------AMELFLLCSDDAESDVRMVADECLNKVIKALMDSNLPRLQLELYKE 175
Query: 263 AAEDKSWRVRYMVADRFSELQKAMGPKIT---LNDLIPAFQNLLKDCEAEVR---AAAAH 316
++ + R RF+EL + P+ L +L+P K E V+ AAA
Sbjct: 176 IKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKRPEESVQETLAAAVP 235
Query: 317 KVKELGENLPIEDRETIIMNQILPYIKELV-----------------SDTNQHVKSALAS 359
K+ N ++ +++ + +K S Q+ S L +
Sbjct: 236 KIMASFGNFANDNEIKVLLKAFIANLKSSSPTIRRTAAGSAVSICQHSRRTQYFYSWLLN 295
Query: 360 VIMGLST----------ILGKENTIEHLLPLFLAQLKD 387
V++GL ILG T+ +L+PL Q+KD
Sbjct: 296 VLLGLLVPVEDEHSTLLILGVLLTLRYLVPLLQQQVKD 333
>gi|93102424 hypothetical protein LOC23116 [Homo sapiens]
Length = 1720
Score = 37.0 bits (84), Expect = 0.052
Identities = 45/213 (21%), Positives = 89/213 (41%), Gaps = 17/213 (7%)
Query: 244 AQLLSQDDLETLVMPTLRQAA--EDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQN 301
A LS +L+ ++P + + + ++ R + ++ P T + + F +
Sbjct: 338 AVTLSNSNLKFGIIPQELHSRLLDQEDYKNRTQAVEELKQVLGKFNPSSTPHSSLVGFIS 397
Query: 302 LLKDCEAEVRAAAAHKVKELGENLPIEDRETI--IMNQILPYIKELVSDTNQHVKSALAS 359
LL + + H E+ L I E + + ++ ++++D +K
Sbjct: 398 LLYNLLDDSNFKVVHGTLEVLHLLVIRLGEQVQQFLGPVIAASVKVLADNKLVIKQEYMK 457
Query: 360 VIMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNLDCV-----NEVIGIRQLSQ 414
+ + L +G + +L L L LK + VR +++ C +E + +LS
Sbjct: 458 IFLKLMKEVGPQQ----VLCLLLEHLKHKHSRVREEVVNICICSLLTYPSEDFDLPKLSF 513
Query: 415 SLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLG 447
L PA+V D+K RVR A +E +LA +G
Sbjct: 514 DLAPALV----DSKRRVRQAALEAFAVLASSMG 542
>gi|112420977 TBP-interacting protein isoform 2 [Homo sapiens]
Length = 1119
Score = 36.6 bits (83), Expect = 0.068
Identities = 39/137 (28%), Positives = 58/137 (42%), Gaps = 10/137 (7%)
Query: 18 GDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIA---LALGVERTRSELLPFLTDTIYDE 74
GDD + +L+D LRNE RL +IK L+ +A L L ++ +E L L +
Sbjct: 514 GDDLEPTLLLLLDRLRNEIT--RLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKN 571
Query: 75 DEVL----LALAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKAVESLRQISQE 130
L LA + L GL P +L L L + V AV+ L ++Q
Sbjct: 572 QRALRLATLAALDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQA 631
Query: 131 HTPVALEAYFVPLVKRL 147
P +L P++ L
Sbjct: 632 Q-PASLVEVSGPVLSEL 647
>gi|19923142 karyopherin beta 1 [Homo sapiens]
Length = 876
Score = 36.6 bits (83), Expect = 0.068
Identities = 29/119 (24%), Positives = 49/119 (41%), Gaps = 9/119 (7%)
Query: 217 IVPLFTSLAS------DEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDKSWR 270
+VP+ T + D+ D A C+ + +DD+ V+P +++ ++ WR
Sbjct: 322 LVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWR 381
Query: 271 VRYMVADRFSELQKAMGP---KITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLP 326
R F + + P K + +P L+KD VR AA V + E LP
Sbjct: 382 YRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP 440
>gi|73695475 protein BAP28 [Homo sapiens]
Length = 2144
Score = 36.2 bits (82), Expect = 0.089
Identities = 36/132 (27%), Positives = 61/132 (46%), Gaps = 12/132 (9%)
Query: 247 LSQDDLETLVMPTLRQ-----AAEDK-SWRVRYMVADRFSELQKAMGPKITLNDLIPAFQ 300
+S++ E L+MP + Q E+K RV + ++ AM L +Q
Sbjct: 2011 ISKERAEALMMPLVDQLENRLGGEEKFQERVTKHLIPCIAQFSVAMADDSLWKPL--NYQ 2068
Query: 301 NLLK--DCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALA 358
LLK D +VR AA V L E L ++ +++ + +P++ EL+ D + V+
Sbjct: 2069 ILLKTRDSSPKVRFAALITVLALAEKL--KENYIVLLPESIPFLAELMEDECEEVEHQCQ 2126
Query: 359 SVIMGLSTILGK 370
I L T+LG+
Sbjct: 2127 KTIQQLETVLGE 2138
Score = 29.6 bits (65), Expect = 8.3
Identities = 43/168 (25%), Positives = 80/168 (47%), Gaps = 14/168 (8%)
Query: 209 ELDSVKSEIVP-LFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQAAEDK 267
+L S+ S +V L +L S ++ VR A++ +++ + S L++ L AE+
Sbjct: 911 QLASISSPVVTSLLINLGSPVKE-VRRAAIQCLQALSGVASPF---YLIIDHLISKAEEI 966
Query: 268 SWRVRYMVADR---FSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGEN 324
+ Y++ D F ELQ+ K + L +NLL C V + ++ K+L +
Sbjct: 967 TSDAAYVIQDLATLFEELQREKKLK-SHQKLSETLKNLLS-C---VYSCPSYIAKDLMKV 1021
Query: 325 LPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTILGKEN 372
L + E ++++Q+LP ++L+ + + L M L LGK N
Sbjct: 1022 LQGVNGE-MVLSQLLPMAEQLLEKIQKEPTAVLKDEAMVLHLTLGKYN 1068
>gi|209969838 transportin 2 (importin 3, karyopherin beta 2b)
isoform 1 [Homo sapiens]
Length = 897
Score = 35.4 bits (80), Expect = 0.15
Identities = 63/285 (22%), Positives = 116/285 (40%), Gaps = 56/285 (19%)
Query: 101 LLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC 160
LL ++ T + +V+DK L+Q++Q Y + ++ RL S D T S
Sbjct: 16 LLKDSQSPNTATQRIVQDK----LKQLNQFPD---FNNYLIFVLTRLKSEDEPTRSLS-- 66
Query: 161 GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPL 220
GL +K ++ ++S +++ + +G+ + + +++ I L
Sbjct: 67 GLI----------LKNNVKAHYQSFPPPVADFIKQECLNNIGDASSL-----IRATIGIL 111
Query: 221 FTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETL--VMPTLRQAAEDKSWRVRYMVADR 278
T++AS + + E + LL+ +D T L++ ED S
Sbjct: 112 ITTIASKGELQ---MWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSS---------- 158
Query: 279 FSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQI 338
EL + LN +IP F K C ++R+ A V + I DR +M+ I
Sbjct: 159 --ELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQF-----IMDRAQALMDNI 211
Query: 339 LPYIKEL----VSDTNQHVKSALASVIMGLSTILGKENTIEHLLP 379
+I+ L V D + K+ +++M L E I+ L+P
Sbjct: 212 DTFIEHLFALAVDDDPEVRKNVCRALVMLL------EVRIDRLIP 250
>gi|209969836 transportin 2 (importin 3, karyopherin beta 2b)
isoform 3 [Homo sapiens]
Length = 887
Score = 35.4 bits (80), Expect = 0.15
Identities = 63/285 (22%), Positives = 116/285 (40%), Gaps = 56/285 (19%)
Query: 101 LLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC 160
LL ++ T + +V+DK L+Q++Q Y + ++ RL S D T S
Sbjct: 16 LLKDSQSPNTATQRIVQDK----LKQLNQFPD---FNNYLIFVLTRLKSEDEPTRSLS-- 66
Query: 161 GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPL 220
GL +K ++ ++S +++ + +G+ + + +++ I L
Sbjct: 67 GLI----------LKNNVKAHYQSFPPPVADFIKQECLNNIGDASSL-----IRATIGIL 111
Query: 221 FTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETL--VMPTLRQAAEDKSWRVRYMVADR 278
T++AS + + E + LL+ +D T L++ ED S
Sbjct: 112 ITTIASKGELQ---MWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSS---------- 158
Query: 279 FSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQI 338
EL + LN +IP F K C ++R+ A V + I DR +M+ I
Sbjct: 159 --ELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQF-----IMDRAQALMDNI 211
Query: 339 LPYIKEL----VSDTNQHVKSALASVIMGLSTILGKENTIEHLLP 379
+I+ L V D + K+ +++M L E I+ L+P
Sbjct: 212 DTFIEHLFALAVDDDPEVRKNVCRALVMLL------EVRIDRLIP 250
>gi|48675813 transportin 2 (importin 3, karyopherin beta 2b) isoform
2 [Homo sapiens]
Length = 887
Score = 35.4 bits (80), Expect = 0.15
Identities = 63/285 (22%), Positives = 116/285 (40%), Gaps = 56/285 (19%)
Query: 101 LLPPLENLATVEETVVRDKAVESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC 160
LL ++ T + +V+DK L+Q++Q Y + ++ RL S D T S
Sbjct: 16 LLKDSQSPNTATQRIVQDK----LKQLNQFPD---FNNYLIFVLTRLKSEDEPTRSLS-- 66
Query: 161 GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASKLGEFAKVLELDSVKSEIVPL 220
GL +K ++ ++S +++ + +G+ + + +++ I L
Sbjct: 67 GLI----------LKNNVKAHYQSFPPPVADFIKQECLNNIGDASSL-----IRATIGIL 111
Query: 221 FTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETL--VMPTLRQAAEDKSWRVRYMVADR 278
T++AS + + E + LL+ +D T L++ ED S
Sbjct: 112 ITTIASKGELQ---MWPELLPQLCNLLNSEDYNTCEGAFGALQKICEDSS---------- 158
Query: 279 FSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQI 338
EL + LN +IP F K C ++R+ A V + I DR +M+ I
Sbjct: 159 --ELLDSDALNRPLNIMIPKFLQFFKHCSPKIRSHAIACVNQF-----IMDRAQALMDNI 211
Query: 339 LPYIKEL----VSDTNQHVKSALASVIMGLSTILGKENTIEHLLP 379
+I+ L V D + K+ +++M L E I+ L+P
Sbjct: 212 DTFIEHLFALAVDDDPEVRKNVCRALVMLL------EVRIDRLIP 250
>gi|7657530 rhabdoid tumor deletion region protein 1 [Homo sapiens]
Length = 348
Score = 33.9 bits (76), Expect = 0.44
Identities = 36/162 (22%), Positives = 67/162 (41%), Gaps = 16/162 (9%)
Query: 293 NDLIPAFQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKELVSDTNQH 352
++++ + L +R+ AA + L ++ E ++ + ++P + L+ D +H
Sbjct: 189 SNVVLVLKQKLLSANQNIRSKAARAL--LNVSISREGKKQVCHFDVIPILVHLLKDPVEH 246
Query: 353 VKSALASVIMGLSTIL-GKENTIE-HLLPLFLAQLKDECPDVRLNIISNLDCVNEVIGIR 410
VKS A +M + I GK +E + L L L RLN L + E R
Sbjct: 247 VKSNAAGALMFATVITEGKYAALEAQAIGLLLELLHSPMTIARLNATKALTMLAEAPEGR 306
Query: 411 QLSQSLLPAI------------VELAEDAKWRVRLAIIEYMP 440
+ Q+ +P V A R+ +++IE+ P
Sbjct: 307 KALQTHVPTFRAMEVETYEKPQVAEALQRAARIAISVIEFKP 348
>gi|163644283 proteasome (prosome, macropain) activator subunit 4
[Homo sapiens]
Length = 1843
Score = 33.1 bits (74), Expect = 0.75
Identities = 34/109 (31%), Positives = 51/109 (46%), Gaps = 9/109 (8%)
Query: 216 EIVPLFTSLASDEQD-SVRLLAVEA--CVSI-AQLLSQDDLETLVMPTLRQAAEDKSWRV 271
+++PLF +A E D S L +A C+S+ +Q L LV+ L+Q A SW
Sbjct: 1598 QLLPLFFKIAPVENDNSYDELKRDAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSWHA 1657
Query: 272 RYMVADR-----FSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAA 315
RY V F L + + + D+ +LL+D + EVR AA
Sbjct: 1658 RYTVLTYLQTMVFYNLFIFLNNEDAVKDIRWLVISLLEDEQLEVREMAA 1706
>gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens]
Length = 679
Score = 31.6 bits (70), Expect = 2.2
Identities = 24/81 (29%), Positives = 40/81 (49%), Gaps = 2/81 (2%)
Query: 247 LSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFSELQKAMGPKI-TLNDLIPAFQ-NLLK 304
LS+DD+E +V + A ED+ + R + + K+ D +PA + N LK
Sbjct: 553 LSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLK 612
Query: 305 DCEAEVRAAAAHKVKELGENL 325
+ +++R A K E GEN+
Sbjct: 613 EEISKMRELLARKDSETGENI 633
>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
Length = 1430
Score = 31.6 bits (70), Expect = 2.2
Identities = 20/47 (42%), Positives = 30/47 (63%), Gaps = 4/47 (8%)
Query: 299 FQNLLKDCEAEVRAAAAHKVKELGENLPIEDRETIIMNQILPYIKEL 345
F ++LK + R A AH ++LG+ + IEDR I+NQIL Y+ +L
Sbjct: 886 FVDVLKLLHIDFRDAVAHASRQLGKPV-IEDR---ILNQILYYLPQL 928
>gi|170784850 SCY1-like 3 isoform 2 [Homo sapiens]
Length = 742
Score = 30.8 bits (68), Expect = 3.7
Identities = 16/91 (17%), Positives = 42/91 (46%)
Query: 202 GEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLR 261
GE +L +S ++P+ L ++ VR++ + + + +Q+ L+ +++P +
Sbjct: 323 GETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVL 382
Query: 262 QAAEDKSWRVRYMVADRFSELQKAMGPKITL 292
D S + + + L +GP++ +
Sbjct: 383 LGLRDTSDSIVAITLHSLAVLVSLLGPEVVV 413
>gi|170784842 SCY1-like 3 isoform 1 [Homo sapiens]
Length = 688
Score = 30.8 bits (68), Expect = 3.7
Identities = 16/91 (17%), Positives = 42/91 (46%)
Query: 202 GEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLR 261
GE +L +S ++P+ L ++ VR++ + + + +Q+ L+ +++P +
Sbjct: 323 GETPCLLSPALFQSRVIPVLLQLFEVHEEHVRMVLLSHIEAYVEHFTQEQLKKVILPQVL 382
Query: 262 QAAEDKSWRVRYMVADRFSELQKAMGPKITL 292
D S + + + L +GP++ +
Sbjct: 383 LGLRDTSDSIVAITLHSLAVLVSLLGPEVVV 413
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 30.8 bits (68), Expect = 3.7
Identities = 42/169 (24%), Positives = 70/169 (41%), Gaps = 18/169 (10%)
Query: 202 GEFAKVLELDSVKSEIVPLFTSLASDEQD-SVRLLAVEACVSIAQLLSQD-DLETLVMPT 259
GEF V ELD + EI L S EQD + A+ S Q L D D ET +
Sbjct: 378 GEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQE 437
Query: 260 LRQAAEDKSWRVRYMVADRFSELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVK 319
L +D DR E+ + K L D++ ++ + C+ E + ++ K +
Sbjct: 438 LEAQKQD--------AQDRLDEMDQ---QKAKLRDML---SDVRQKCQDETQMISSLKTQ 483
Query: 320 ELGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASVIMGLSTIL 368
+ ++ +E +N+ + L + Q +S A + L TI+
Sbjct: 484 IQSQESDLKSQED-DLNRAKSELNRLQQEETQLEQSIQAGRVQ-LETII 530
>gi|109948292 hypothetical protein LOC57614 [Homo sapiens]
Length = 1216
Score = 30.8 bits (68), Expect = 3.7
Identities = 22/73 (30%), Positives = 39/73 (53%), Gaps = 1/73 (1%)
Query: 204 FAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEACVSIAQLLSQDDLETLVMPTLRQ- 262
FA+ + V++E++P + + RLL E+C ++A L ++ +LV+ L+Q
Sbjct: 588 FARHVGPTRVEAELLPQCWEQINHKYPERRLLVAESCGALAPYLPKEIRSSLVLSMLQQM 647
Query: 263 AAEDKSWRVRYMV 275
EDK+ VR V
Sbjct: 648 LMEDKADLVREAV 660
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 30.4 bits (67), Expect = 4.9
Identities = 32/116 (27%), Positives = 55/116 (47%), Gaps = 3/116 (2%)
Query: 486 GTEWAQNTIVPKVLVMANDPNYLHRMTTLFCI-NALSEACGQEITTKQMLPIVLKMAGDQ 544
G +Q+ ++ +L+ D + + R + F + NA +A +P + ++ GD
Sbjct: 1145 GALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDP 1204
Query: 545 VANVRFNVAKSLQKIGPI-LDTNALQGEV-KPVLQKLGQDEDMDVKYFAQEAISVL 598
A +R NVA +L +GP L LQ EV + +L+ D +VK A A+ L
Sbjct: 1205 QAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSL 1260
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 30.4 bits (67), Expect = 4.9
Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 29/245 (11%)
Query: 25 IAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSEL--LPFLTDTIYDEDEVLLALA 82
+ VLI+ L ++V+ ++ S+K L I+ + + +L LP + + + + L LA
Sbjct: 496 LEVLINLLETDEVKCKIGSLKILKEISHNPQIRQNIVDLGGLPIMVNILDSPHKSLKCLA 555
Query: 83 -----------------EQLGNFTGLVGGPDFAHCLLPPLE-NLATVEETVVRDKAVESL 124
Q G T LV D AH P + +L + V +L
Sbjct: 556 AETIANVAKFKRARRVVRQHGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALAL 615
Query: 125 RQISQEHT--PVALEAYFVPLVKRLASGDWFTSRTSACGLFSVCYPRAS--NAVKAE--I 178
S+ HT +A +PL+ RL G C + A+KAE I
Sbjct: 616 WSCSKSHTNKEAIRKAGGIPLLARLLKTSHENMLIPVVGTLQECASEENYRAAIKAERII 675
Query: 179 RQQFRSLCSDDTPMVRRAAAS--KLGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLA 236
++L S++ + A + + E + +L + + PL SL ++ + RL A
Sbjct: 676 ENLVKNLNSENEQLQEHCAMAIYQCAEDKETRDLVRLHGGLKPL-ASLLNNTDNKERLAA 734
Query: 237 VEACV 241
V +
Sbjct: 735 VTGAI 739
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,425,121
Number of Sequences: 37866
Number of extensions: 752135
Number of successful extensions: 2306
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2120
Number of HSP's gapped (non-prelim): 103
length of query: 601
length of database: 18,247,518
effective HSP length: 108
effective length of query: 493
effective length of database: 14,157,990
effective search space: 6979889070
effective search space used: 6979889070
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.