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Search of human proteins with 32307161
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32307161 cullin 1 [Homo sapiens]
(776 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32307161 cullin 1 [Homo sapiens] 1538 0.0
gi|19482174 cullin 2 [Homo sapiens] 515 e-146
gi|4503165 cullin 3 [Homo sapiens] 372 e-103
gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1 ... 340 2e-93
gi|121114302 cullin 4B isoform 2 [Homo sapiens] 339 5e-93
gi|121114298 cullin 4B isoform 1 [Homo sapiens] 339 5e-93
gi|57165424 cullin 4A isoform 1 [Homo sapiens] 328 9e-90
gi|11140811 cullin 4A isoform 2 [Homo sapiens] 328 9e-90
gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens] 60 1e-08
gi|41872646 cullin 7 [Homo sapiens] 55 2e-07
gi|169218008 PREDICTED: similar to anaphase-promoting complex su... 39 0.014
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 39 0.014
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 35 0.20
gi|38044112 restin isoform b [Homo sapiens] 35 0.20
gi|4506751 restin isoform a [Homo sapiens] 35 0.20
gi|222537714 taxilin beta [Homo sapiens] 34 0.45
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 34 0.45
gi|94538362 flotillin 2 [Homo sapiens] 33 0.77
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 33 1.0
gi|154146191 heat shock 90kDa protein 1, alpha isoform 2 [Homo s... 33 1.3
gi|153792590 heat shock 90kDa protein 1, alpha isoform 1 [Homo s... 33 1.3
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 32 1.7
gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens] 32 2.2
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 32 2.2
gi|33946313 ninein isoform 4 [Homo sapiens] 31 3.8
gi|33946321 ninein isoform 5 [Homo sapiens] 31 3.8
gi|148536871 ninein isoform 1 [Homo sapiens] 31 3.8
gi|148536869 ninein isoform 2 [Homo sapiens] 31 3.8
gi|148839335 dpy-19-like 1 [Homo sapiens] 31 3.8
gi|221316695 multimerin 2 precursor [Homo sapiens] 31 5.0
>gi|32307161 cullin 1 [Homo sapiens]
Length = 776
Score = 1538 bits (3983), Expect = 0.0
Identities = 776/776 (100%), Positives = 776/776 (100%)
Query: 1 MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSN 60
MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSN
Sbjct: 1 MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSN 60
Query: 61 QARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYT 120
QARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYT
Sbjct: 61 QARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYT 120
Query: 121 QQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVT 180
QQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVT
Sbjct: 121 QQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVT 180
Query: 181 NAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADT 240
NAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADT
Sbjct: 181 NAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADT 240
Query: 241 ERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL 300
ERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL
Sbjct: 241 ERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL 300
Query: 301 EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAAL 360
EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAAL
Sbjct: 301 EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAAL 360
Query: 361 NDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPE 420
NDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPE
Sbjct: 361 NDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPE 420
Query: 421 LLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA 480
LLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA
Sbjct: 421 LLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA 480
Query: 481 SDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVL 540
SDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVL
Sbjct: 481 SDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVL 540
Query: 541 SSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYT 600
SSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYT
Sbjct: 541 SSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYT 600
Query: 601 LQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDE 660
LQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDE
Sbjct: 601 LQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDE 660
Query: 661 VELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMK 720
VELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMK
Sbjct: 661 VELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMK 720
Query: 721 MRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
MRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
Sbjct: 721 MRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
>gi|19482174 cullin 2 [Homo sapiens]
Length = 745
Score = 515 bits (1327), Expect = e-146
Identities = 285/779 (36%), Positives = 450/779 (57%), Gaps = 58/779 (7%)
Query: 15 IGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKK 74
+ D+ W+ L I+ V + + ++ + + ++ +Y C + +
Sbjct: 8 VDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEP--------------- 52
Query: 75 GQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLN 134
+G LY K FL+N++ +L K + +E VL Y + WE+Y + ++
Sbjct: 53 ---------LGERLYTETKIFLENHVRHLHKRVLE-SEEQVLVMYHRYWEEYSKGADYMD 102
Query: 135 GICAYLNRHWVRR----ECD--------EGRKGIYEIYSLALVTWRDCLFRPLNKQVTNA 182
+ YLN ++++ E D + + + EI LAL WR + PL +
Sbjct: 103 CLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRM 162
Query: 183 VLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTER 242
+L+ I+ +R GE N ++I GV+ S+V + + + K L Y+E FES FL +T
Sbjct: 163 LLREIKNDRGGEDPNQKVIHGVINSFVHV-----EQYKKKFPLKFYQEIFESPFLTETGE 217
Query: 243 FYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEI 302
+Y +E++ LQ++ ++YM+K RL +E+ R + YLH S+ ++ +C+Q ++ HL+
Sbjct: 218 YYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQF 277
Query: 303 FHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALND 362
H E N++ +K D+ MY L+ + GL + + L+ HIH++GL A + N
Sbjct: 278 LHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQE--NM 335
Query: 363 PKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELL 422
P ++V++VL+VH K+ L+ + N D F++ALDKA +N + +S K+PELL
Sbjct: 336 PTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNY----REPKSVCKAPELL 391
Query: 423 ARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASD 482
A+YCD+LLKKS+K E E+ED L + VFKYI+DKDVFQKFYA+MLAKRL+H S S
Sbjct: 392 AKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSM 451
Query: 483 DAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE---PLDLDFSIQV 539
D+E +MI+KLKQACG+E+TSKL RM+ D+ VS DLN +F + N + L + F I V
Sbjct: 452 DSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYV 511
Query: 540 LSSGSWPFQQ--SCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKN 597
L +G+WP Q S TFA+P ELE+S Q F FY+ SGRKLTWL+ L GE+ N
Sbjct: 512 LQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGK 571
Query: 598 RYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENAN 657
Y +T+QMA+LL +N + + ++L DSTQ+ L + ++ LL K++ + E +
Sbjct: 572 PYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKED 631
Query: 658 VDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVR 717
+D ++ L + + +K+ + I M+ + QE E T ++EDRK+ +QAAIVR
Sbjct: 632 ID-----AESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVR 686
Query: 718 IMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
IMK RKVL+H L+ EV++Q +RF P + +IKKCI++LI+K+Y+ER D YSY+A
Sbjct: 687 IMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 745
>gi|4503165 cullin 3 [Homo sapiens]
Length = 768
Score = 372 bits (954), Expect = e-103
Identities = 245/794 (30%), Positives = 414/794 (52%), Gaps = 89/794 (11%)
Query: 17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQ 76
++ IWD L+ IQ++ + + S + ELY + Y H
Sbjct: 30 VNSIWDLLKNAIQEIQRKNNSGLS-FEELYRNAYTMVLHKH------------------- 69
Query: 77 TPGGAQFVGLELYKRLKEFLKNYLTNLLK-DGEDLMDESVLKFYTQQWEDYRFSSKVLNG 135
G +LY L+E + +L N ++ D + ++ + L+ Q W D++ + ++
Sbjct: 70 --------GEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRD 121
Query: 136 ICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRP--LNKQVTNAVLKLIEKERNG 193
I Y++R +V++ + +Y+L L+ +RD + R + + +L +I +ER G
Sbjct: 122 ILMYMDRVYVQQN------NVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKG 175
Query: 194 ETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQ 253
E ++ I Q + LGL +VY+E FE+ FL + F+ ES +FL
Sbjct: 176 EVVDRGAIRNACQMLMILGLEGR---------SVYEEDFEAPFLEMSAEFFQMESQKFLA 226
Query: 254 QNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL----EIFHTEFQN 309
+N + Y+KK EAR+ EE RV L +ST++ + + E+ LI KH+ E+ ++ +
Sbjct: 227 ENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVH 286
Query: 310 LLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQT 369
+L K EDLG MY L SR+ +GL + + + +++ QG A + + GE +P Y+Q
Sbjct: 287 MLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEG--KNPVDYIQG 344
Query: 370 VLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSL 429
+LD+ +++ ++ +FNND F + F+N N S+SPE L+ + D
Sbjct: 345 LLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLN---------SRSPEYLSLFIDDK 395
Query: 430 LKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMI 489
LKK K E E+E L++ MV+F+++++KDVF+++Y + LA+RL+ S SDD+E +MI
Sbjct: 396 LKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMI 455
Query: 490 SKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL--TNSEPLDLDFSIQVLSSGSWPF 547
SKLK CG ++TSKL+ MF+D+ +S ++F++HL T +D +++VL++G WP
Sbjct: 456 SKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPT 515
Query: 548 QQSCTFA-LPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGEL---------------- 590
Q + +P +++ F FY ++HSGR+LT + + +L
Sbjct: 516 QSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEV 575
Query: 591 ------VTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILL 644
VT ++ LQ STFQM IL+ +N + YT +++ T I L + LQ L
Sbjct: 576 GVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLA 635
Query: 645 --KSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKN 702
K VL E + E+E + K ++++ + E E++ T +
Sbjct: 636 CGKPTQRVLTKEPKS-KEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQK 694
Query: 703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYL 762
+++DRK I+AAIVRIMK RK ++H L+ EV QL +RF P VIKK I+ LIE+EYL
Sbjct: 695 VDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYL 754
Query: 763 ERVDGEKDTYSYLA 776
R ++ Y+Y+A
Sbjct: 755 ARTPEDRKVYTYVA 768
>gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1
[Homo sapiens]
Length = 780
Score = 340 bits (873), Expect = 2e-93
Identities = 238/794 (29%), Positives = 411/794 (51%), Gaps = 70/794 (8%)
Query: 21 WDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGG 80
WD +R + ++ ++S+ K ++ +L++ V+ C + P+K +
Sbjct: 19 WDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKG---------PAKIHQA----- 64
Query: 81 AQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYL 140
L + + EF+K +L +D ++LK Y +W + +L L
Sbjct: 65 -------LKEDILEFIKQAQARVLSHQDDT---ALLKAYIVEWRKFFTQCDILPKPFCQL 114
Query: 141 NRHWVRRECDEGRKGIYE--IYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINT 198
+ ++ + + + + L L TW + +F + ++ ++ +KL+ ER GE ++
Sbjct: 115 EITLMGKQGSNKKSNVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDS 174
Query: 199 RLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVT 258
+L+ GV +SYV L N +D L +Y+++FE +L TERFY ++ +LQQN V
Sbjct: 175 QLVIGVRESYVNLCSNPEDK------LQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQ 228
Query: 259 EYMKKAEARLLEEQRRVQVYLHESTQ----DELARKCEQVLIEKHLEIFHTEFQNLLDAD 314
YMK A+A+L EE++R YL + + L C L+ E E Q ++ +
Sbjct: 229 NYMKYADAKLKEEEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRN 288
Query: 315 KNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVH 374
+ E L M++L+ ++ +G+ + K LE HI + GLA + E D + YV+ +L +
Sbjct: 289 ETEKLHLMFSLMDKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLF 348
Query: 375 KKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKM------------AQSSSKSPELL 422
+++ LV AF +D F+ A DKA +N+ + K+ Q SK PELL
Sbjct: 349 NRFSKLVKEAFQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELL 408
Query: 423 ARYCDSLLKKS--SKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA 480
A YCD LL+K+ SK E+E L +V++V KY+++KDVF +++ L +RL+ SA
Sbjct: 409 ANYCDMLLRKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISA 468
Query: 481 SDDAEASMISKLKQ-ACGFEYTSKLQRMFQDIGVSKDLNEQFKK-HLTNSEPLDLD-FSI 537
+ E +M+ L++ +Y +KL RMFQDI VS+DLN+ FK+ H N L D +I
Sbjct: 469 DSEIEENMVEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNI 528
Query: 538 QVLSSGSWPFQQSCTF-ALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFK 596
++L++G+W F +LP+ELE FY HSGRKL W + +S G +
Sbjct: 529 KILNAGAWSRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEV 588
Query: 597 NRYTLQASTFQMAILLQYN--TEDAYTVQQLTDSTQIKMDILAQVLQIL-----LKSKLL 649
+Y L+ +TFQ+A+L +N + + + L +T++ L + L L LK ++L
Sbjct: 589 GQYDLEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVL 648
Query: 650 VLEDE-NANVDEVE------LKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKN 702
+ E + N+ D E + +LIK K K+ + + + TE+ +E+E ++
Sbjct: 649 LYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEE--NEG 706
Query: 703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYL 762
I + R L Q AI++IMKMRK + + QL E++ L + F P+ +IK+ I+ LIE +Y+
Sbjct: 707 IVQLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYI 766
Query: 763 ERVDGEKDTYSYLA 776
R + + +T+ Y+A
Sbjct: 767 RRDESDINTFIYMA 780
>gi|121114302 cullin 4B isoform 2 [Homo sapiens]
Length = 895
Score = 339 bits (870), Expect = 5e-93
Identities = 239/768 (31%), Positives = 391/768 (50%), Gaps = 77/768 (10%)
Query: 18 DQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQT 77
D+ W L+ ++ + S+ K ELY V N C+ +N
Sbjct: 196 DETWQKLKEAVEAIQNSTSI-KYNLEELYQAVENLCSYKISAN----------------- 237
Query: 78 PGGAQFVGLELYKRLKEFLKNYL-TNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNG 135
LYK+L++ ++++ + + ED +D + LK + W+++ ++
Sbjct: 238 ----------LYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRS 287
Query: 136 ICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLF--RPLNKQVTNAVLKLIEKERNG 193
I +L+R +V + + I+ + L +R + + + + + +L LIE+ERNG
Sbjct: 288 IFLFLDRTYVLQN-----SMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG 342
Query: 194 ETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQ 253
E I+ L+ ++ +L +Y++SFE +FL +T R Y E + +Q
Sbjct: 343 EAIDRSLLRSLLSMLSDL--------------QIYQDSFEQRFLEETNRLYAAEGQKLMQ 388
Query: 254 QNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLE-IFHTEFQNLLD 312
+ V EY+ RL EE R+ YL ++TQ L E+ L+ +HL I NLLD
Sbjct: 389 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD 448
Query: 313 ADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDP---KMYVQT 369
++ +DL +Y L SR++ G+ L + Q + I+ G + +P K VQ
Sbjct: 449 ENRIQDLSLLYQLFSRVRGGVQVLLQ--------QWIEYIKAFGSTIVINPEKDKTMVQE 500
Query: 370 VLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSL 429
+LD K + ++ F + F+ A+ +A FIN +K EL+A+Y DS
Sbjct: 501 LLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRP--------NKPAELIAKYVDSK 552
Query: 430 LKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMI 489
L+ +K + ELE L+++M++F++I KDVF+ FY K LAKRL+ SAS DAE SM+
Sbjct: 553 LRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSML 612
Query: 490 SKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPFQ 548
SKLK CG +TSKL+ MF+D+ +SKD+ QFK+++ N P +++ ++ +L+ G WP
Sbjct: 613 SKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTY 672
Query: 549 QSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQM 608
LP E+ + + F FY +HSGRKL W L L + + LQ S FQ
Sbjct: 673 VPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQT 732
Query: 609 AILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTL 668
+LL +N + ++++++ +T I+ L + LQ L K VL +N ++E D
Sbjct: 733 LVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLA-KNPKGKDIE-DGDKF 790
Query: 669 IKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQ 728
I +K+K R+ IN E +EQ +T + + +DR+ I AAIVRIMKMRK L H
Sbjct: 791 I-CNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHN 849
Query: 729 QLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
L+ EV QL KP +KK I+ LI+++Y+ER + Y+Y+A
Sbjct: 850 LLVSEVYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYNYIA 895
>gi|121114298 cullin 4B isoform 1 [Homo sapiens]
Length = 913
Score = 339 bits (870), Expect = 5e-93
Identities = 239/768 (31%), Positives = 391/768 (50%), Gaps = 77/768 (10%)
Query: 18 DQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQT 77
D+ W L+ ++ + S+ K ELY V N C+ +N
Sbjct: 214 DETWQKLKEAVEAIQNSTSI-KYNLEELYQAVENLCSYKISAN----------------- 255
Query: 78 PGGAQFVGLELYKRLKEFLKNYL-TNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNG 135
LYK+L++ ++++ + + ED +D + LK + W+++ ++
Sbjct: 256 ----------LYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRS 305
Query: 136 ICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLF--RPLNKQVTNAVLKLIEKERNG 193
I +L+R +V + + I+ + L +R + + + + + +L LIE+ERNG
Sbjct: 306 IFLFLDRTYVLQN-----SMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNG 360
Query: 194 ETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQ 253
E I+ L+ ++ +L +Y++SFE +FL +T R Y E + +Q
Sbjct: 361 EAIDRSLLRSLLSMLSDL--------------QIYQDSFEQRFLEETNRLYAAEGQKLMQ 406
Query: 254 QNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLE-IFHTEFQNLLD 312
+ V EY+ RL EE R+ YL ++TQ L E+ L+ +HL I NLLD
Sbjct: 407 EREVPEYLHHVNKRLEEEADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLD 466
Query: 313 ADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDP---KMYVQT 369
++ +DL +Y L SR++ G+ L + Q + I+ G + +P K VQ
Sbjct: 467 ENRIQDLSLLYQLFSRVRGGVQVLLQ--------QWIEYIKAFGSTIVINPEKDKTMVQE 518
Query: 370 VLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSL 429
+LD K + ++ F + F+ A+ +A FIN +K EL+A+Y DS
Sbjct: 519 LLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKRP--------NKPAELIAKYVDSK 570
Query: 430 LKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMI 489
L+ +K + ELE L+++M++F++I KDVF+ FY K LAKRL+ SAS DAE SM+
Sbjct: 571 LRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSML 630
Query: 490 SKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE-PLDLDFSIQVLSSGSWPFQ 548
SKLK CG +TSKL+ MF+D+ +SKD+ QFK+++ N P +++ ++ +L+ G WP
Sbjct: 631 SKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNIELTVNILTMGYWPTY 690
Query: 549 QSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQM 608
LP E+ + + F FY +HSGRKL W L L + + LQ S FQ
Sbjct: 691 VPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQT 750
Query: 609 AILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTL 668
+LL +N + ++++++ +T I+ L + LQ L K VL +N ++E D
Sbjct: 751 LVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLA-KNPKGKDIE-DGDKF 808
Query: 669 IKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQ 728
I +K+K R+ IN E +EQ +T + + +DR+ I AAIVRIMKMRK L H
Sbjct: 809 I-CNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHN 867
Query: 729 QLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
L+ EV QL KP +KK I+ LI+++Y+ER + Y+Y+A
Sbjct: 868 LLVSEVYNQLKFPVKP--ADLKKRIESLIDRDYMERDKENPNQYNYIA 913
>gi|57165424 cullin 4A isoform 1 [Homo sapiens]
Length = 759
Score = 328 bits (842), Expect = 9e-90
Identities = 228/698 (32%), Positives = 366/698 (52%), Gaps = 49/698 (7%)
Query: 88 LYKRLKEFLKNYL-TNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWV 145
LYK+L++ ++++ +L ED +D + LK W+D+ ++ I +L+R +V
Sbjct: 102 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 161
Query: 146 RRECDEGRKGIYEIYSLALVTWRDCLF--RPLNKQVTNAVLKLIEKERNGETINTRLISG 203
+ + I+ + L +R + + + + + +L LIE+ER+GE ++ L+
Sbjct: 162 LQNST-----LPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRS 216
Query: 204 VVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKK 263
+ LG+ D L VYK+SFE +FL +T Y E +Q+ V EY+
Sbjct: 217 L------LGMLSD--------LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNH 262
Query: 264 AEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLE-IFHTEFQNLLDADKNEDLGRM 322
RL EE RV YL STQ L E+ L+ +HL I +LLD ++ DL +M
Sbjct: 263 VSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQM 322
Query: 323 YNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVM 382
Y L SR++ G L + +I G A + + K VQ +LD K + ++
Sbjct: 323 YQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIE 377
Query: 383 SAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAEL 442
F + FV + ++ FIN +K EL+A++ DS L+ +K + EL
Sbjct: 378 VCFQKNERFVNLMKESFETFINKRP--------NKPAELIAKHVDSKLRAGNKEATDEEL 429
Query: 443 EDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTS 502
E TL+++M++F++I KDVF+ FY K LAKRL+ SAS DAE SM+SKLK CG +TS
Sbjct: 430 ERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTS 489
Query: 503 KLQRMFQDIGVSKDLNEQFKKHLTN-SEPLDLDFSIQVLSSGSWPFQQSCTFALPSELER 561
KL+ MF+D+ +SKD+ FK+H+ N S+ +D ++ +L+ G WP L E+ +
Sbjct: 490 KLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIK 549
Query: 562 SYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYT 621
+ F AFY +HSGRKL W L L + + Q S FQ +LL +N D ++
Sbjct: 550 LQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFS 609
Query: 622 VQQLTDSTQIKMDILAQVLQILL--KSKLLVLEDENANVDEVELKPDTLIKLYLG-YKNK 678
+++ +T I+ L + LQ L K+++L+ + V++ + ++ G +K+K
Sbjct: 610 FEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDK------FIFNGEFKHK 663
Query: 679 KLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQL 738
R+ IN E +EQ +T + + +DR+ I AAIVRIMKMRK L H L+ E+ QL
Sbjct: 664 LFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQL 723
Query: 739 SSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
KP +KK I+ LI+++Y+ER + Y Y+A
Sbjct: 724 KFPVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
>gi|11140811 cullin 4A isoform 2 [Homo sapiens]
Length = 659
Score = 328 bits (842), Expect = 9e-90
Identities = 228/698 (32%), Positives = 366/698 (52%), Gaps = 49/698 (7%)
Query: 88 LYKRLKEFLKNYL-TNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWV 145
LYK+L++ ++++ +L ED +D + LK W+D+ ++ I +L+R +V
Sbjct: 2 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 61
Query: 146 RRECDEGRKGIYEIYSLALVTWRDCLF--RPLNKQVTNAVLKLIEKERNGETINTRLISG 203
+ + I+ + L +R + + + + + +L LIE+ER+GE ++ L+
Sbjct: 62 LQNST-----LPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRS 116
Query: 204 VVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKK 263
+ LG+ D L VYK+SFE +FL +T Y E +Q+ V EY+
Sbjct: 117 L------LGMLSD--------LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNH 162
Query: 264 AEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLE-IFHTEFQNLLDADKNEDLGRM 322
RL EE RV YL STQ L E+ L+ +HL I +LLD ++ DL +M
Sbjct: 163 VSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQM 222
Query: 323 YNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVM 382
Y L SR++ G L + +I G A + + K VQ +LD K + ++
Sbjct: 223 YQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIE 277
Query: 383 SAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAEL 442
F + FV + ++ FIN +K EL+A++ DS L+ +K + EL
Sbjct: 278 VCFQKNERFVNLMKESFETFINKRP--------NKPAELIAKHVDSKLRAGNKEATDEEL 329
Query: 443 EDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTS 502
E TL+++M++F++I KDVF+ FY K LAKRL+ SAS DAE SM+SKLK CG +TS
Sbjct: 330 ERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTS 389
Query: 503 KLQRMFQDIGVSKDLNEQFKKHLTN-SEPLDLDFSIQVLSSGSWPFQQSCTFALPSELER 561
KL+ MF+D+ +SKD+ FK+H+ N S+ +D ++ +L+ G WP L E+ +
Sbjct: 390 KLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIK 449
Query: 562 SYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYT 621
+ F AFY +HSGRKL W L L + + Q S FQ +LL +N D ++
Sbjct: 450 LQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFS 509
Query: 622 VQQLTDSTQIKMDILAQVLQILL--KSKLLVLEDENANVDEVELKPDTLIKLYLG-YKNK 678
+++ +T I+ L + LQ L K+++L+ + V++ + ++ G +K+K
Sbjct: 510 FEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDK------FIFNGEFKHK 563
Query: 679 KLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQL 738
R+ IN E +EQ +T + + +DR+ I AAIVRIMKMRK L H L+ E+ QL
Sbjct: 564 LFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQL 623
Query: 739 SSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
KP +KK I+ LI+++Y+ER + Y Y+A
Sbjct: 624 KFPVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
>gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens]
Length = 822
Score = 59.7 bits (143), Expect = 1e-08
Identities = 43/195 (22%), Positives = 92/195 (47%), Gaps = 5/195 (2%)
Query: 459 KDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLN 518
KD+F Y +LA RL+HQ S S + E + LK G + M +D+ S+ +N
Sbjct: 512 KDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRIN 571
Query: 519 ----EQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRH 574
E+ +K +P +++ +LSS WP + +P ++ + + + Y
Sbjct: 572 ANIREEDEKRPAEEQPPFGVYAV-ILSSEFWPPFKDEKLEVPEDIRAALEAYCKKYEQLK 630
Query: 575 SGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMD 634
+ R L+W + L + ++ + Q ILL + + ++T+++L+ + ++ +
Sbjct: 631 AMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVA 690
Query: 635 ILAQVLQILLKSKLL 649
+L + + + L+ +L
Sbjct: 691 LLRRRMSVWLQQGVL 705
>gi|41872646 cullin 7 [Homo sapiens]
Length = 1698
Score = 55.5 bits (132), Expect = 2e-07
Identities = 63/202 (31%), Positives = 94/202 (46%), Gaps = 28/202 (13%)
Query: 534 DFSIQVLSSGSWPFQQSC-----TFALPSELERSYQRFTAFY--------ASRHSGRKLT 580
+ S+ VLS SWP C LPS L + R++ FY R S R+L
Sbjct: 1388 EVSVLVLSRHSWPVASICHTLNPRTCLPSYLRGTLNRYSNFYNKSQSHPALERGSQRRLQ 1447
Query: 581 WLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVL 640
W + L EL F N+ TL ST QM +LL N A +V+ L + + D+L Q +
Sbjct: 1448 WTW-LGWAELQ---FGNQ-TLHVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQAI 1502
Query: 641 QILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNI--NVPMKTEQKQEQET 698
L S+ + E ++ P ++K+ G K + R +I +P +T + E E
Sbjct: 1503 GPLTSSRGPLDLHEQKDI------PGGVLKIRDGSKEPRSRWDIVRLIPPQTYLQAEGE- 1555
Query: 699 THKNIEEDRKLLIQAAIVRIMK 720
+N+E+ R LL IVRI+K
Sbjct: 1556 DGQNLEKRRNLL-NCLIVRILK 1576
Score = 37.0 bits (84), Expect = 0.070
Identities = 40/154 (25%), Positives = 69/154 (44%), Gaps = 19/154 (12%)
Query: 385 FNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEE----- 439
F A F+ AL C + K A S E AR+ D ++ S +
Sbjct: 1187 FGPRAAFLLALQNGCAGALLKLPFLKAAHVS----EQFARHIDQQIQGSRIGGAQEMERL 1242
Query: 440 AELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFE 499
A+L+ L Q +++F +E F+ +Y +A RL+ S E +++ ++ G
Sbjct: 1243 AQLQQCL-QAVLIFSGLEIATTFEHYYQHYMADRLL--GVVSSWLEGAVLEQI----GPC 1295
Query: 500 YTSKL-QRMFQDIGVSKDLNEQFKKHLTNSEPLD 532
+ ++L Q+M Q + SK+L QF H+ + LD
Sbjct: 1296 FPNRLPQQMLQSLSTSKELQRQF--HVYQLQQLD 1327
>gi|169218008 PREDICTED: similar to anaphase-promoting complex
subunit 2 [Homo sapiens]
Length = 430
Score = 39.3 bits (90), Expect = 0.014
Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 5/116 (4%)
Query: 459 KDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLN 518
KD+F Y +LA RL+HQ S S + E + LK G + M +D+ S+ +N
Sbjct: 286 KDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLKDMADSRRIN 345
Query: 519 ----EQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFY 570
E+ +K +P +++ +LSS WP + +P ++ + + + Y
Sbjct: 346 ANIREEDEKRPAEEQPPFGVYAV-ILSSEFWPPFKDEKLEVPEDIRAALEAYCKKY 400
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 39.3 bits (90), Expect = 0.014
Identities = 33/144 (22%), Positives = 70/144 (48%), Gaps = 19/144 (13%)
Query: 612 LQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLE---------DENANVDEVE 662
LQ +T+ A + + +M+I + L ++ L+ LE DE + ++
Sbjct: 468 LQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADIS 527
Query: 663 LKPDTLIKLYLGYKN--------KKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAA 714
+ + + + Y+N ++L V + +T +++EQETT I E +L +++A
Sbjct: 528 SSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITE-LQLKLESA 586
Query: 715 IVRIMKMRKVLKHQ-QLLGEVLTQ 737
+ + ++RK +HQ QL+ ++ Q
Sbjct: 587 LTELEQLRKSRQHQMQLVDSIVRQ 610
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 35.4 bits (80), Expect = 0.20
Identities = 32/146 (21%), Positives = 67/146 (45%), Gaps = 14/146 (9%)
Query: 608 MAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDT 667
MA+ +Y+ + A +QL ++ ++++ Q L+ +N + D V+ +
Sbjct: 139 MAVRSKYSEDKANLQKQLEEAMNTQLELSEQ------------LKFQNNSEDNVKKLQEE 186
Query: 668 LIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLK- 726
+ K+ G++ + L + + T++K+E T +NI E Q I + + LK
Sbjct: 187 IEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA 246
Query: 727 -HQQLLGEVLTQLSSRFKPRVPVIKK 751
HQ+ + E++ Q+ + K I K
Sbjct: 247 IHQEEVKELMCQIEASAKEHEAEINK 272
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 35.4 bits (80), Expect = 0.20
Identities = 122/571 (21%), Positives = 213/571 (37%), Gaps = 106/571 (18%)
Query: 183 VLKLI-EKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTE 241
++K+I EKE + E I ++L Q VE+ ED TL +E+ +
Sbjct: 653 LMKVIKEKENSLEAIRSKLDKAEDQHLVEM---ED-------TLNKLQEAEIKVKELEVL 702
Query: 242 RFYTRESTEFLQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIE-KH 299
+ E T+ + T +K E +LL+ + R +S +L ++ E + KH
Sbjct: 703 QAKCNEQTKVIDN--FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH 760
Query: 300 LEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA- 358
LEI + + E GR L + +Q+ L E+ ++ ET + + EK EA
Sbjct: 761 LEIEKNAESSKASSITRELQGRELKLTN-LQENLSEVSQVKET-LEKELQILKEKFAEAS 818
Query: 359 --ALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSS 416
A++ + +TV +H+K M SS
Sbjct: 819 EEAVSVQRSMQETVNKLHQKEEQFNML-------------------------------SS 847
Query: 417 KSPELLARYCDSLLKKSSKNPEEAEL----EDTLNQVMVVFKYIEDKDVFQKFYAKMLAK 472
+L D K K+ E +L E N + + K D + L K
Sbjct: 848 DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDN-------SSQLTK 900
Query: 473 RLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLD 532
D E +LK E S LQ+ +D+ V + ++Q E +
Sbjct: 901 MNDELRLKERDVEEL---QLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE 957
Query: 533 LDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRH-------------SGRKL 579
L+ + L C EL+ Y+R T+ ++H + KL
Sbjct: 958 LERKLSDLEKKMETSHNQC-----QELKARYERATSETKTKHEEILQNLQKTLLDTEDKL 1012
Query: 580 TWLYQLSKG------ELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKM 633
+ + G EL K + Q + M I+ Q E T+ L D+ Q
Sbjct: 1013 KGAREENSGLLQELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1071
Query: 634 DILAQV----------LQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRV- 682
+ ++ ++ L KSK L L EN ++E + +TL K K+++L
Sbjct: 1072 KLQNELDTLKENNLKNVEELNKSKEL-LTVENQKMEEFRKEIETL-KQAAAQKSQQLSAL 1129
Query: 683 ---NINVPMKTEQKQEQETTHKNIEEDRKLL 710
N+ + + + +++ T+H+ +EE+R +L
Sbjct: 1130 QEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 35.4 bits (80), Expect = 0.20
Identities = 122/571 (21%), Positives = 213/571 (37%), Gaps = 106/571 (18%)
Query: 183 VLKLI-EKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTE 241
++K+I EKE + E I ++L Q VE+ ED TL +E+ +
Sbjct: 688 LMKVIKEKENSLEAIRSKLDKAEDQHLVEM---ED-------TLNKLQEAEIKVKELEVL 737
Query: 242 RFYTRESTEFLQQNPVTEYMKKAEARLLE-EQRRVQVYLHESTQDELARKCEQVLIE-KH 299
+ E T+ + T +K E +LL+ + R +S +L ++ E + KH
Sbjct: 738 QAKCNEQTKVIDN--FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKH 795
Query: 300 LEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA- 358
LEI + + E GR L + +Q+ L E+ ++ ET + + EK EA
Sbjct: 796 LEIEKNAESSKASSITRELQGRELKLTN-LQENLSEVSQVKET-LEKELQILKEKFAEAS 853
Query: 359 --ALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSS 416
A++ + +TV +H+K M SS
Sbjct: 854 EEAVSVQRSMQETVNKLHQKEEQFNML-------------------------------SS 882
Query: 417 KSPELLARYCDSLLKKSSKNPEEAEL----EDTLNQVMVVFKYIEDKDVFQKFYAKMLAK 472
+L D K K+ E +L E N + + K D + L K
Sbjct: 883 DLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDN-------SSQLTK 935
Query: 473 RLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLD 532
D E +LK E S LQ+ +D+ V + ++Q E +
Sbjct: 936 MNDELRLKERDVEEL---QLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE 992
Query: 533 LDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRH-------------SGRKL 579
L+ + L C EL+ Y+R T+ ++H + KL
Sbjct: 993 LERKLSDLEKKMETSHNQC-----QELKARYERATSETKTKHEEILQNLQKTLLDTEDKL 1047
Query: 580 TWLYQLSKG------ELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKM 633
+ + G EL K + Q + M I+ Q E T+ L D+ Q
Sbjct: 1048 KGAREENSGLLQELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1106
Query: 634 DILAQV----------LQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRV- 682
+ ++ ++ L KSK L L EN ++E + +TL K K+++L
Sbjct: 1107 KLQNELDTLKENNLKNVEELNKSKEL-LTVENQKMEEFRKEIETL-KQAAAQKSQQLSAL 1164
Query: 683 ---NINVPMKTEQKQEQETTHKNIEEDRKLL 710
N+ + + + +++ T+H+ +EE+R +L
Sbjct: 1165 QEENVKLAEELGRSRDEVTSHQKLEEERSVL 1195
>gi|222537714 taxilin beta [Homo sapiens]
Length = 684
Score = 34.3 bits (77), Expect = 0.45
Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 11/126 (8%)
Query: 658 VDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVR 717
+D+ EL+ + L K++ + ++ V+ + E +E E HK E LL QAA +
Sbjct: 286 IDQYELREEHLDKIFKHRELQQKLVDAKLEQAQEMMKEAEERHK--REKEYLLNQAAEWK 343
Query: 718 IMKMRKVLKHQQ-LLGEVLTQLSSRFKPRVPVIKKCIDIL------IEKEYLERVDGEKD 770
+ KVLK Q+ +L LT S RF+ + K ++ ++K + EKD
Sbjct: 344 L--QAKVLKEQETVLQAQLTLYSGRFEEFQSTLTKSNEVFATFKQEMDKTTKKMKKLEKD 401
Query: 771 TYSYLA 776
T ++ A
Sbjct: 402 TATWKA 407
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 34.3 bits (77), Expect = 0.45
Identities = 57/305 (18%), Positives = 117/305 (38%), Gaps = 49/305 (16%)
Query: 246 RESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQD----------ELARKCEQVL 295
RE L+Q E K A+ +L++Q +V +S Q EL+RK E++
Sbjct: 597 RERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQ 656
Query: 296 I----------EKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLET--- 342
E ++ E Q + K + R+ ++Q+ L LK+ L+
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716
Query: 343 ---HIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKAC 399
+ A+E+ + +++ K +++++ HK+ + G A L +
Sbjct: 717 SLEEEKRRAADALEE-QQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ-- 773
Query: 400 GRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDK 459
+ ++ E+L R + ++++ E+E E + +V + ED
Sbjct: 774 -----------LGEAHQAETEVLRRELAEAM--AAQHTAESECEQLVKEVAAWRERYEDS 820
Query: 460 DVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNE 519
+ Y M ++L+ + A + ++ G E S+LQ +S+ NE
Sbjct: 821 QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ-------ISRQQNE 873
Query: 520 QFKKH 524
+ H
Sbjct: 874 LAELH 878
Score = 31.2 bits (69), Expect = 3.8
Identities = 61/332 (18%), Positives = 131/332 (39%), Gaps = 39/332 (11%)
Query: 243 FYTRESTEFLQQ-----NPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIE 297
F RE LQQ N +TE KA LE+Q +++ L + QD+ + + +++
Sbjct: 325 FKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQ 384
Query: 298 KHLEIFHTEFQNLLD---ADKNEDLGRMYNLVSRIQDG---------LGELKKLLETHIH 345
L L D +K E LG + L + Q+ L ++LET
Sbjct: 385 GKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERG 444
Query: 346 NQGLAAIEKCGEAALNDPKMYVQTVL--------DVHKKYNALVMSAFNNDAGFVAALDK 397
Q + + G + K + +++ ++ + L ++ + A A +
Sbjct: 445 QQEAKLLAERGH--FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
Query: 398 ACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEA---------ELEDTLNQ 448
NA + + A+ + L ++ + E+A +L +L Q
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 449 VMVVFKYIEDK-DVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRM 507
K + +K + ++ +A+ LA + ++ + +A++ K +A E +KL+ +
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAAL--KQLEALEKEKAAKLEIL 620
Query: 508 FQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQV 539
Q + V+ + + + +T ++ + S +V
Sbjct: 621 QQQLQVANEARDSAQTSVTQAQREKAELSRKV 652
>gi|94538362 flotillin 2 [Homo sapiens]
Length = 428
Score = 33.5 bits (75), Expect = 0.77
Identities = 41/162 (25%), Positives = 76/162 (46%), Gaps = 13/162 (8%)
Query: 202 SGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTE-- 259
+ VVQ ++G+ E + A KE + +F+ADT+ ++ + E LQ++ +E
Sbjct: 172 TAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFE-LQKSAFSEEV 230
Query: 260 YMKKAEARL---LEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKN 316
+K AEA+L L+ R Q E + E+ ++ +Q+ +E EI T+ + + +
Sbjct: 231 NIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQ-EILRTDKELIATVRRP 289
Query: 317 EDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEA 358
+ RIQ + E +K+ + + I K GEA
Sbjct: 290 AEAE-----AHRIQQ-IAEGEKVKQVLLAQAEAEKIRKIGEA 325
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 33.1 bits (74), Expect = 1.0
Identities = 64/310 (20%), Positives = 132/310 (42%), Gaps = 42/310 (13%)
Query: 427 DSLLKKSSKNPE-EAELEDTLNQVMVVFKYIEDKDV-FQKFYAK--MLAKRLVHQNSASD 482
+ LL+K+S + + E+E+ +Q++ + K +E+K V + AK L + L+ +N
Sbjct: 676 EELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIR 735
Query: 483 DAEASMISKLKQAC-GFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLS 541
E ++ ++ ++ C FE K+ + K++ +Q ++ E D F
Sbjct: 736 SLETNINTEHEKICLAFEKAKKIH-----LEQHKEMEKQIERLEAQLEKKDQQFK----- 785
Query: 542 SGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTL 601
+Q T ++ + +H L L SKGE+ K L
Sbjct: 786 ------EQEKTMSMLQQ---------DIICKQHHLESLDRLLTESKGEMKKENMKKDEAL 830
Query: 602 QASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEV 661
+A Q+ +E+ V+QL + +I + L L L +K + +EV
Sbjct: 831 KALQNQV-------SEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEV 883
Query: 662 E-LKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIE-EDRKLLIQAAIVRIM 719
L+ + IK + + + V + ++ +Q+ Q+ T +N E ED + ++ ++
Sbjct: 884 YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEK---QVS 940
Query: 720 KMRKVLKHQQ 729
K+ + L+ Q+
Sbjct: 941 KLEQELQKQR 950
>gi|154146191 heat shock 90kDa protein 1, alpha isoform 2 [Homo
sapiens]
Length = 732
Score = 32.7 bits (73), Expect = 1.3
Identities = 49/233 (21%), Positives = 99/233 (42%), Gaps = 38/233 (16%)
Query: 87 ELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSS-KVLNGICAYLNRHWV 145
E YK L +++L E ++ L F ++ F + K N I Y+ R ++
Sbjct: 311 EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFI 370
Query: 146 RRECDE-------GRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINT 198
C+E +G+ + L L R+ L + + +LK+I K
Sbjct: 371 MDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQ-------SKILKVIRKN-------- 415
Query: 199 RLISGVVQSYVELGLNED------DAFAKGPTLTVYKESFESQFLADTERFYTRESTEFL 252
L+ ++ + EL +++ + F+K L ++++S + L++ R+YT S + +
Sbjct: 416 -LVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEM 474
Query: 253 QQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH-LEIFH 304
+K R+ E Q+ + Y+ T+D++A + KH LE+ +
Sbjct: 475 VS------LKDYCTRMKENQKHI-YYITGETKDQVANSAFVERLRKHGLEVIY 520
>gi|153792590 heat shock 90kDa protein 1, alpha isoform 1 [Homo
sapiens]
Length = 854
Score = 32.7 bits (73), Expect = 1.3
Identities = 49/233 (21%), Positives = 99/233 (42%), Gaps = 38/233 (16%)
Query: 87 ELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSS-KVLNGICAYLNRHWV 145
E YK L +++L E ++ L F ++ F + K N I Y+ R ++
Sbjct: 433 EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFI 492
Query: 146 RRECDE-------GRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINT 198
C+E +G+ + L L R+ L + + +LK+I K
Sbjct: 493 MDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQ-------SKILKVIRKN-------- 537
Query: 199 RLISGVVQSYVELGLNED------DAFAKGPTLTVYKESFESQFLADTERFYTRESTEFL 252
L+ ++ + EL +++ + F+K L ++++S + L++ R+YT S + +
Sbjct: 538 -LVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEM 596
Query: 253 QQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKH-LEIFH 304
+K R+ E Q+ + Y+ T+D++A + KH LE+ +
Sbjct: 597 VS------LKDYCTRMKENQKHI-YYITGETKDQVANSAFVERLRKHGLEVIY 642
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 32.3 bits (72), Expect = 1.7
Identities = 32/120 (26%), Positives = 56/120 (46%), Gaps = 16/120 (13%)
Query: 644 LKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVN-INVPMKTEQKQEQETTHKN 702
LKS ++L DE N+ E K ++ +V+ +N K EQ + + T K
Sbjct: 501 LKSFTVMLVDERKNMMEK-------------IKQEERKVDGLNKNFKVEQGKVMDVTEKL 547
Query: 703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLT--QLSSRFKPRVPVIKKCIDILIEKE 760
IEE +KLL + + + +L+G++ + + SS V ++KK +D + E E
Sbjct: 548 IEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVE 607
>gi|13899233 tetratricopeptide repeat domain 25 [Homo sapiens]
Length = 672
Score = 32.0 bits (71), Expect = 2.2
Identities = 28/114 (24%), Positives = 51/114 (44%), Gaps = 10/114 (8%)
Query: 234 SQFLADTERFYTRESTEFLQQNPVTEYMKKAEAR----LLEEQRRVQVYLHESTQDELAR 289
S F + Y RE L Q K+ ++ +L+ + + L + + +
Sbjct: 236 SNFWRQQKPIYARERDRKLMQEKWLRDHKRRPSQTAHYILKSLEDIDMLLTSGSAEGSLQ 295
Query: 290 KCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETH 343
K E+VL +K LE E N K+E +G +Y+ + Q LG+++ L++H
Sbjct: 296 KAEKVL-KKVLEWNKEEVPN-----KDELVGNLYSCIGNAQIELGQMEAALQSH 343
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 32.0 bits (71), Expect = 2.2
Identities = 51/245 (20%), Positives = 99/245 (40%), Gaps = 20/245 (8%)
Query: 500 YTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSI---QVLSSGSWPFQQSCTFALP 556
Y L ++I L E+FKK+ N+ S Q+LS Q ++
Sbjct: 707 YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLS-------QVKELSMV 759
Query: 557 SELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNT 616
+EL ++ A R+L + Q + L+T + +++A + + I + N
Sbjct: 760 TELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS-LSIEAKSKDVKIEVLQNE 818
Query: 617 EDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYK 676
D +Q ST I+ LQ L++K + + V + K + L +
Sbjct: 819 LDDVQLQFSEQSTLIRS------LQSQLQNKESEVLEGAERVRHISSKVEELSQ---ALS 869
Query: 677 NKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLT 736
K+L + + E+K++ ET + IEE + + + + KM ++ + + LG +
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Query: 737 QLSSR 741
L +
Sbjct: 930 TLKEQ 934
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 31.2 bits (69), Expect = 3.8
Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 12/118 (10%)
Query: 233 ESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKC- 291
E+QF +D ++ E E Q+ Y + E + L+EQ+R + E +DEL ++C
Sbjct: 821 EAQFQSDCQK--VTERCESALQSLEGRY--RQELKDLQEQQREEKSQWEFEKDELTQECA 876
Query: 292 -------EQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLET 342
E + EK + T+ + +L+ E L M ++ L +L+ + ET
Sbjct: 877 EAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 934
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 31.2 bits (69), Expect = 3.8
Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 12/118 (10%)
Query: 233 ESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKC- 291
E+QF +D ++ E E Q+ Y + E + L+EQ+R + E +DEL ++C
Sbjct: 815 EAQFQSDCQK--VTERCESALQSLEGRY--RQELKDLQEQQREEKSQWEFEKDELTQECA 870
Query: 292 -------EQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLET 342
E + EK + T+ + +L+ E L M ++ L +L+ + ET
Sbjct: 871 EAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 31.2 bits (69), Expect = 3.8
Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 12/118 (10%)
Query: 233 ESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKC- 291
E+QF +D ++ E E Q+ Y + E + L+EQ+R + E +DEL ++C
Sbjct: 815 EAQFQSDCQK--VTERCESALQSLEGRY--RQELKDLQEQQREEKSQWEFEKDELTQECA 870
Query: 292 -------EQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLET 342
E + EK + T+ + +L+ E L M ++ L +L+ + ET
Sbjct: 871 EAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 31.2 bits (69), Expect = 3.8
Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 12/118 (10%)
Query: 233 ESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKC- 291
E+QF +D ++ E E Q+ Y + E + L+EQ+R + E +DEL ++C
Sbjct: 815 EAQFQSDCQK--VTERCESALQSLEGRY--RQELKDLQEQQREEKSQWEFEKDELTQECA 870
Query: 292 -------EQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLET 342
E + EK + T+ + +L+ E L M ++ L +L+ + ET
Sbjct: 871 EAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSMVVERQQLLQDLEDLRNVSET 928
>gi|148839335 dpy-19-like 1 [Homo sapiens]
Length = 675
Score = 31.2 bits (69), Expect = 3.8
Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 5/67 (7%)
Query: 319 LGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYN 378
L Y + ++I D +G K+ T +GL+ IE C L DP + V+ + N
Sbjct: 113 LASWYRIYTKIMDLIGIQTKICWTVTRGEGLSPIESC--EGLGDPACFYVAVIFI---LN 167
Query: 379 ALVMSAF 385
L+M+ F
Sbjct: 168 GLMMALF 174
>gi|221316695 multimerin 2 precursor [Homo sapiens]
Length = 949
Score = 30.8 bits (68), Expect = 5.0
Identities = 13/36 (36%), Positives = 25/36 (69%), Gaps = 3/36 (8%)
Query: 296 IEKHLEIFHT---EFQNLLDADKNEDLGRMYNLVSR 328
+E+H +FH+ FQ L++A+ + DLG++ ++SR
Sbjct: 744 LEQHQRLFHSLFGNFQGLMEANVSLDLGKLQTMLSR 779
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,953,195
Number of Sequences: 37866
Number of extensions: 1072142
Number of successful extensions: 3827
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 3734
Number of HSP's gapped (non-prelim): 86
length of query: 776
length of database: 18,247,518
effective HSP length: 110
effective length of query: 666
effective length of database: 14,082,258
effective search space: 9378783828
effective search space used: 9378783828
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.