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Search of human proteins with 31543615
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
(302 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo ... 602 e-172
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 189 3e-48
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 186 2e-47
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 183 2e-46
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 177 1e-44
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 177 1e-44
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B... 131 8e-31
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 83 3e-16
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 80 2e-15
gi|40254992 carbonic reductase 4 [Homo sapiens] 75 9e-14
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 68 9e-12
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 66 4e-11
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 65 1e-10
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 64 2e-10
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 64 2e-10
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 63 3e-10
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 63 3e-10
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 62 6e-10
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 62 6e-10
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 61 1e-09
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 60 2e-09
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap... 60 2e-09
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 60 3e-09
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo... 58 9e-09
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 58 1e-08
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 57 3e-08
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 56 3e-08
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 54 2e-07
gi|150247226 retinol dehydrogenase 16 [Homo sapiens] 54 2e-07
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 53 3e-07
>gi|31543615 dehydrogenase/reductase (SDR family) member 3 [Homo
sapiens]
Length = 302
Score = 602 bits (1553), Expect = e-172
Identities = 302/302 (100%), Positives = 302/302 (100%)
Query: 1 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE 60
MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE
Sbjct: 1 MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAE 60
Query: 61 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL 120
RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL
Sbjct: 61 RGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITIL 120
Query: 121 VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS 180
VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS
Sbjct: 121 VNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALS 180
Query: 181 AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP 240
AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP
Sbjct: 181 AIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPP 240
Query: 241 LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG 300
LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG
Sbjct: 241 LKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKG 300
Query: 301 RT 302
RT
Sbjct: 301 RT 302
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 189 bits (479), Expect = 3e-48
Identities = 106/293 (36%), Positives = 167/293 (56%), Gaps = 4/293 (1%)
Query: 9 LVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVL 68
L +F + ++ +++A + +LP ++++ E VLITG G G+GR LA +FA G+ +VL
Sbjct: 11 LFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGS-VLVL 69
Query: 69 WGRTEKCLKETTEEIRQMG-TECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVV 127
W ++ +ET + R+ G T H + CD +E VY+ A V+++VGD++IL+NNA +V
Sbjct: 70 WDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIV 129
Query: 128 HGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAID 187
GK +D D+ + KS +N WT KAFLP M+ +GH+VC++S LS + G D
Sbjct: 130 TGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLAD 189
Query: 188 YCTSKASAFAFMESLTLG--LLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPET 245
YC SK +AF F ES+ + + G+ T V PF T MF+G P+L P L+P+
Sbjct: 190 YCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKY 249
Query: 246 VARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTF 298
+ VEA+ + L +P ++ ++ LKS LP I + G M+ F
Sbjct: 250 AVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGF 302
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 186 bits (473), Expect = 2e-47
Identities = 111/294 (37%), Positives = 169/294 (57%), Gaps = 11/294 (3%)
Query: 18 YLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLK 77
Y +++ V ++P K ++++ E VL TG G G+GRQLA FA GA +VLW ++
Sbjct: 16 YYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAI-LVLWDVNQEGNM 74
Query: 78 ETTEEIRQMGTECHY-FICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSD 136
ET ++ G + + + CD NR+EVY+ A VR++ GD+TILVNNA +V GK +D
Sbjct: 75 ETCRLAKEKGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIP 134
Query: 137 DDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAID-------YC 189
D + KS +N + FWT KAFLP +++ +GH+VC++S+ + I G D Y
Sbjct: 135 DHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYS 194
Query: 190 TSKASAFAFMESL--TLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVA 247
SK +AF F ESL L ++ V +T V P +T MF+G ++P L P L+ E VA
Sbjct: 195 ASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQEYVA 254
Query: 248 RRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGR 301
++ + A+ Q L++P + +ILK I+ L ++ G TCM +FKGR
Sbjct: 255 KKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMASFKGR 308
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 183 bits (464), Expect = 2e-46
Identities = 109/313 (34%), Positives = 167/313 (53%), Gaps = 30/313 (9%)
Query: 15 QMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEK 74
++++ V AA ++ K + ++ + LITG G G+GR A EFA R A +VLW +
Sbjct: 13 KVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRAL-LVLWDINTQ 71
Query: 75 CLKETTEEIRQM-------------------------GTECHYFICDVGNREEVYQTAKA 109
+ET +R + + + CDVG RE VY TA+
Sbjct: 72 SNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAER 131
Query: 110 VREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGH 169
VR++VG++++LVNNA VV G L++ D+ + ++ +N FWTTKAFLP MLE+ +GH
Sbjct: 132 VRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGH 191
Query: 170 IVCLNSVLALSAIPGAIDYCTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMF 227
IV + S L L + G DYC SK F ESL+ L + G+ T V P+ T MF
Sbjct: 192 IVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMF 251
Query: 228 QGMRVR--FPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEI 285
+G R+R PPLKP+ ++ ++A+ +Q ++ P M+ + +KSILP A+ +
Sbjct: 252 RGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCM 311
Query: 286 HKFSGTYTCMNTF 298
++F G CM F
Sbjct: 312 YRFLGADKCMYPF 324
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 177 bits (449), Expect = 1e-44
Identities = 95/275 (34%), Positives = 159/275 (57%), Gaps = 6/275 (2%)
Query: 9 LVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVL 68
+++ + +IY +++ V +P + + ++ E VLITG G GIGRQ EFA+R + +VL
Sbjct: 7 ILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSI-LVL 65
Query: 69 WGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVH 128
W ++ ++ET E R++G H ++ D NREE+Y++ V+++VGD+TI+VNNA V+
Sbjct: 66 WDINKRGVEETAAECRKLGVTAHAYVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVY 125
Query: 129 GKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDY 188
L+ + D+ + K+ +N LG FW TKA LP M+E +GHIV + SV IP I Y
Sbjct: 126 PADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPY 185
Query: 189 CTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETV 246
C+SK +A F LT L L G+ + + P +T + R L+P L+ + V
Sbjct: 186 CSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR---LWPVLETDEV 242
Query: 247 ARRTVEAVQLNQALLLLPWTMHALVILKSILPQAA 281
R ++ + N+ ++ +P ++ + L+ LP+ A
Sbjct: 243 VRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERA 277
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 177 bits (448), Expect = 1e-44
Identities = 102/279 (36%), Positives = 160/279 (57%), Gaps = 7/279 (2%)
Query: 6 LGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARK 65
L L++ PL +I +++ V L +P + + ++ E VLITG G GIGR A EFA+ + K
Sbjct: 5 LDILLLLPL-LIVCSLESFVKLFIPKRRKSVTGEIVLITGAGHGIGRLTAYEFAKLKS-K 62
Query: 66 IVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAA 125
+VLW + L+ET + + +G + H F+ D NRE++Y +AK V+ ++GD++ILVNNA
Sbjct: 63 LVLWDINKHGLEETAAKCKGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAG 122
Query: 126 VVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGA 185
VV+ L + D + K+ +N L FWTTKAFLP M + +GHIV + S ++P
Sbjct: 123 VVYTSDLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFL 182
Query: 186 IDYCTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKP 243
+ YC+SK +A F ++LT L L GV T + P +T + +L P L+P
Sbjct: 183 LAYCSSKFAAVGFHKTLTDELAALQITGVKTTCLCPNFVNTGFIKNPST---SLGPTLEP 239
Query: 244 ETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAAL 282
E V R + + Q ++ +P ++ L L+ ILP+ L
Sbjct: 240 EEVVNRLMHGILTEQKMIFIPSSIAFLTTLERILPERFL 278
>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
[Homo sapiens]
Length = 264
Score = 131 bits (329), Expect = 8e-31
Identities = 84/275 (30%), Positives = 138/275 (50%), Gaps = 42/275 (15%)
Query: 9 LVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVL 68
+++ + +IY +++ V +P + + ++ E VLITG G GIGRQ EFA+R + +VL
Sbjct: 7 ILLLLITIIYSYLESLVKFFIPQRRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSI-LVL 65
Query: 69 WGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVH 128
W D+ V+++VGD+TI+VNNA V+
Sbjct: 66 W--------------------------DINK----------VKKEVGDVTIVVNNAGTVY 89
Query: 129 GKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDY 188
L+ + D+ + K+ +N LG FW TKA LP M+E +GHIV + SV IP I Y
Sbjct: 90 PADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPY 149
Query: 189 CTSKASAFAFMESLT--LGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETV 246
C+SK +A F LT L L G+ + + P +T + R L+P L+ + V
Sbjct: 150 CSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTR---LWPVLETDEV 206
Query: 247 ARRTVEAVQLNQALLLLPWTMHALVILKSILPQAA 281
R ++ + N+ ++ +P ++ + L+ LP+ A
Sbjct: 207 VRSLIDGILTNKKMIFVPSYINIFLRLQKFLPERA 241
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 83.2 bits (204), Expect = 3e-16
Identities = 59/186 (31%), Positives = 85/186 (45%), Gaps = 11/186 (5%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFIC----- 95
V +TG GIG +LA + ++ G +VL R L+ + G I
Sbjct: 53 VWVTGASSGIGEELAYQLSKLGV-SLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
Query: 96 --DVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFW 153
D G+ E KAV ++ G I ILVNN + MD+ D K +N LG
Sbjct: 112 LTDTGSHEAA---TKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVS 168
Query: 154 TTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVS 213
TK LP M+E + G IV +NS+L + ++P +I YC SK + F L L PG+
Sbjct: 169 LTKCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATYPGII 228
Query: 214 ATTVLP 219
+ + P
Sbjct: 229 VSNICP 234
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 80.1 bits (196), Expect = 2e-15
Identities = 67/248 (27%), Positives = 114/248 (45%), Gaps = 10/248 (4%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIR-----QMGTECHYFIC 95
V+ITG G+G++ A+ F GA K+VL GR L+E E+ ++ T Y +
Sbjct: 55 VVITGATSGLGKECAKVFYAAGA-KLVLCGRNGGALEELIRELTASHATKVQTHKPYLVT 113
Query: 96 -DVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWT 154
D+ + + A + + G + ILVNNA + + ++MD+ D + N G
Sbjct: 114 FDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVAL 173
Query: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSA 214
TKA LP M++ + GHIV ++S+ +IP Y SK + AF + L ++ +
Sbjct: 174 TKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLR-AEMEQYEIEV 232
Query: 215 TTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILK 274
T + P + T + + + + T R+ V++ Q +L VIL
Sbjct: 233 TVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRS--PVEVAQDVLAAVGKKKKDVILA 290
Query: 275 SILPQAAL 282
+LP A+
Sbjct: 291 DLLPSLAV 298
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 74.7 bits (182), Expect = 9e-14
Identities = 61/234 (26%), Positives = 102/234 (43%), Gaps = 15/234 (6%)
Query: 43 ITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREE 102
+ GG RGIGR +A+ A +G R V+ + L+ +G + F CDV +
Sbjct: 7 VFGGSRGIGRAVAQLMARKGYRLAVI----ARNLEGAKAAAGDLGGDHLAFSCDVAKEHD 62
Query: 103 VYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRM 162
V T + + + +G + LVN A + L+ + + ++ H N LG T KA + M
Sbjct: 63 VQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTM 122
Query: 163 LELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHT 222
++ Q G IV + S++ L G Y SK F +L + + V P
Sbjct: 123 IQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVAR-KKIRVNVVAPGFV 181
Query: 223 STEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLL---PW-TMHALVI 272
T+M + ++ LK R E +++ A++ L P+ T H LV+
Sbjct: 182 HTDMTKDLKEEH------LKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVV 229
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 68.2 bits (165), Expect = 9e-12
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 2/172 (1%)
Query: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFIC 95
L+ + L+T GIG +AR A+ GA +V+ R ++ + + ++ G +C
Sbjct: 30 LANKVALVTASTDGIGFAIARRLAQDGAH-VVVSSRKQQNVDQAVATLQGEGLSVTGTVC 88
Query: 96 DVGNREEVYQTAKAVREKVGDITILVNNAAV-VHGKSLMDSDDDALLKSQHINTLGQFWT 154
VG E+ + + G I ILV+NAAV S+MD ++ K+ IN
Sbjct: 89 HVGKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALM 148
Query: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGL 206
TKA +P M + G +V ++S+ A S PG Y SK + ++L + L
Sbjct: 149 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIEL 200
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 65.9 bits (159), Expect = 4e-11
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 15/215 (6%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVL--------WGRTEKCLKETTEEIRQMGTECHY 92
VL+TG G G+GR A FAERGA +V G+ + EEIR+ G +
Sbjct: 12 VLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGKA-- 69
Query: 93 FICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQF 152
+ + + EE + K + G I ++VNNA ++ +S D+ ++ G F
Sbjct: 70 -VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVHLRGSF 128
Query: 153 WTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGV 212
T+A M + + G I+ +S + G +Y +K SL + +
Sbjct: 129 QVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEGRK-SNI 187
Query: 213 SATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVA 247
T+ P + + M Q V +L LKPE VA
Sbjct: 188 HCNTIAP-NAGSRMTQ--TVMPEDLVEALKPEYVA 219
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 64.7 bits (156), Expect = 1e-10
Identities = 50/172 (29%), Positives = 80/172 (46%), Gaps = 2/172 (1%)
Query: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFIC 95
L+ + L+T GIG +AR A+ A +V+ R ++ + + ++ G +C
Sbjct: 30 LTNKVALVTASTDGIGFAIARRLAQDRAH-VVVSSRKQQNVDQAVATLQGEGLSVTGTVC 88
Query: 96 DVGNREEVYQTAKAVREKVGDITILVNNAAV-VHGKSLMDSDDDALLKSQHINTLGQFWT 154
VG E+ + + G I ILV+NAAV SLMD ++ K+ IN
Sbjct: 89 HVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPALM 148
Query: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGL 206
TKA +P M + G +V ++S+ A S PG Y SK + +L + L
Sbjct: 149 TKAVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLNNTLAIEL 200
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 63.9 bits (154), Expect = 2e-10
Identities = 51/191 (26%), Positives = 93/191 (48%), Gaps = 16/191 (8%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNR 100
+++T +GIG+ A FA GA K++ E L+E E+ + T + DV +
Sbjct: 9 IILTAAAQGIGQAAALAFAREGA-KVIATDINESKLQEL-EKYPGIQTR----VLDVTKK 62
Query: 101 EEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLP 160
+++ Q A V + +L N A VH +++D ++ S ++N + KAFLP
Sbjct: 63 KQIDQFANEVER----LDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRSMYLMIKAFLP 118
Query: 161 RMLELQNGHIVCLNSVLALSAIPGAIDYC---TSKASAFAFMESLTLGLLDCPGVSATTV 217
+ML ++G+I+ ++SV S++ G ++ C T+KA+ +S+ + G+ V
Sbjct: 119 KMLAQKSGNIINMSSV--ASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQ-QGIRCNCV 175
Query: 218 LPFHTSTEMFQ 228
P T Q
Sbjct: 176 CPGTVDTPSLQ 186
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 63.9 bits (154), Expect = 2e-10
Identities = 43/149 (28%), Positives = 77/149 (51%), Gaps = 8/149 (5%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEK-------CLKETTEEIRQMGTECHYF 93
V ITG RGIG+ +A + A+ GA IV+ +T + + EEI +G +
Sbjct: 13 VFITGASRGIGKAIALKAAKDGAN-IVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKALPC 71
Query: 94 ICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFW 153
I DV + +++ + +K G I ILVNNA+ + + +D+ L ++NT G +
Sbjct: 72 IVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYL 131
Query: 154 TTKAFLPRMLELQNGHIVCLNSVLALSAI 182
+KA +P + + + HI+ ++ L L+ +
Sbjct: 132 ASKACIPYLKKSKVAHILNISPPLNLNPV 160
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 63.2 bits (152), Expect = 3e-10
Identities = 46/168 (27%), Positives = 78/168 (46%), Gaps = 3/168 (1%)
Query: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMG-TECHYFI 94
L + V++TG +GIGR++A A+ GA +V+ R+++ L++ ++G HY
Sbjct: 32 LQGKKVIVTGASKGIGREMAYHLAKMGAH-VVVTARSKETLQKVVSHCLELGAASAHYIA 90
Query: 95 CDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWT 154
+ + Q + +G + +L+ N +L D + KS +N L
Sbjct: 91 GTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVL 150
Query: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202
T A LP ML+ NG IV ++S+ A P Y SK + F S+
Sbjct: 151 TVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSI 197
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 63.2 bits (152), Expect = 3e-10
Identities = 46/168 (27%), Positives = 78/168 (46%), Gaps = 3/168 (1%)
Query: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMG-TECHYFI 94
L + V++TG +GIGR++A A+ GA +V+ R+++ L++ ++G HY
Sbjct: 32 LQGKKVIVTGASKGIGREMAYHLAKMGAH-VVVTARSKETLQKVVSHCLELGAASAHYIA 90
Query: 95 CDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWT 154
+ + Q + +G + +L+ N +L D + KS +N L
Sbjct: 91 GTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVL 150
Query: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202
T A LP ML+ NG IV ++S+ A P Y SK + F S+
Sbjct: 151 TVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSI 197
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 62.0 bits (149), Expect = 6e-10
Identities = 62/223 (27%), Positives = 102/223 (45%), Gaps = 13/223 (5%)
Query: 39 ENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQ-MGTECHYFICDV 97
E ++TG GIG+ A E A+ G K+VL R++ L + + EI++ E D
Sbjct: 51 EWAVVTGSTDGIGKSYAEELAKHGM-KVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDF 109
Query: 98 GNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSD----DDALLKSQHINTLGQFW 153
+ E++Y K + +I ILVNN + + D D+ + K +IN L
Sbjct: 110 AS-EDIYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCK 167
Query: 154 TTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVS 213
T+ LP M+E G I+ ++S + +P Y +K F + L GV
Sbjct: 168 MTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRS-KGVF 226
Query: 214 ATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQL 256
+VLP+ +T++ ++R P L P PET + ++ V L
Sbjct: 227 VQSVLPYFVATKL---AKIRKPTLDKP-SPETFVKSAIKTVGL 265
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 62.0 bits (149), Expect = 6e-10
Identities = 53/171 (30%), Positives = 80/171 (46%), Gaps = 14/171 (8%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYF-----IC 95
V+IT G+G++ AR F GAR +VL G+ + L+ + + + F +
Sbjct: 40 VVITDAISGLGKECARVFHTGGAR-LVLCGKNWERLENLYDALISVADPSKTFTPKLVLL 98
Query: 96 DVGNREEVYQTAKAVREKVGDITILVNNAAV-VHG---KSLMDSDDDALLKSQHINTLGQ 151
D+ + V AK V + G + IL+NNA+V V G K ++ D K N G
Sbjct: 99 DLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDK----KIMDANYFGP 154
Query: 152 FWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202
TKA LP M+ + G IV +N++ IP Y SK +A F + L
Sbjct: 155 ITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGFFDCL 205
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 61.2 bits (147), Expect = 1e-09
Identities = 55/224 (24%), Positives = 94/224 (41%), Gaps = 15/224 (6%)
Query: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHY--FICDVGN 99
L+TG GIG +AR ++G K+V RT ++E E + G + CD+ N
Sbjct: 15 LVTGASGGIGAAVARALVQQGL-KVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSN 73
Query: 100 REEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFL 159
E++ A+R + + I +NNA + +L+ ++N L T+
Sbjct: 74 EEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSICTREAY 133
Query: 160 PRMLE--LQNGHIVCLNSVLALSAIPGAID--YCTSKASAFAFMESLTLGLLDC-PGVSA 214
M E + +GHI+ +NS+ +P ++ Y +K + A E L L + + A
Sbjct: 134 QSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRA 193
Query: 215 TTVLPFHTSTEMFQGMRVRFP-------NLFPPLKPETVARRTV 251
T + P T+ + + P LKPE VA +
Sbjct: 194 TCISPGVVETQFAFKLHDKDPEKAAATYEQMKCLKPEDVAEAVI 237
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 60.5 bits (145), Expect = 2e-09
Identities = 50/199 (25%), Positives = 92/199 (46%), Gaps = 12/199 (6%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNR 100
V++TGGGRGIG + R F GAR +V+ + E + +E+ + +CDV
Sbjct: 12 VVVTGGGRGIGAGIVRAFVNSGAR-VVICDKDESGGRALEQEL----PGAVFILCDVTQE 66
Query: 101 EEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDA--LLKSQHINTLGQFWTTKAF 158
++V + G + +VNNA H + A + +N LG + TK
Sbjct: 67 DDVKTLVSETIRRFGRLDCVVNNAG-HHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLA 125
Query: 159 LPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCP-GVSATTV 217
LP + + Q G+++ ++S++ A+ Y +K + A ++L L + P GV +
Sbjct: 126 LPYLRKSQ-GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALD--ESPYGVRVNCI 182
Query: 218 LPFHTSTEMFQGMRVRFPN 236
P + T +++ + P+
Sbjct: 183 SPGNIWTPLWEELAALMPD 201
>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
sapiens]
Length = 318
Score = 60.1 bits (144), Expect = 2e-09
Identities = 64/215 (29%), Positives = 94/215 (43%), Gaps = 18/215 (8%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEE--IRQMGTECHYFICDVG 98
V ITG G GR LA + +RG R + CL + E R + H + D+
Sbjct: 31 VFITGCDSGFGRLLALQLDQRGFRVLA------SCLTPSGAEDLQRVASSRLHTTLLDIT 84
Query: 99 NREEVYQTAKAVREKVGDITI--LVNNAAV--VHGKSLMDSDDDALLKSQHINTLGQFWT 154
+ + V Q AK V V + + LVNNA V + G + + DD + ++NT+G
Sbjct: 85 DPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDD-FQRVLNVNTMGPIGV 143
Query: 155 TKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSA 214
T A LP +L+ G ++ + SVL A G YC SK AF +SL + G+
Sbjct: 144 TLALLP-LLQQARGRVINITSVLGRLAANGG-GYCVSKFGLEAFSDSLRRDVAHF-GIRV 200
Query: 215 TTVLP--FHTSTEMFQGMRVRFPNLFPPLKPETVA 247
+ V P F T + + + L P T A
Sbjct: 201 SIVEPGFFRTPVTNLESLEKTLQACWARLPPATQA 235
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 59.7 bits (143), Expect = 3e-09
Identities = 74/262 (28%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 9 LVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVL 68
LV F L ++Y+V L+ P L L +V++TGG GIG+ +A E ++GA I L
Sbjct: 9 LVAFVL-LLYMVSP----LISPKPLA-LPGAHVVVTGGSSGIGKCIAIECYKQGAF-ITL 61
Query: 69 WGRTEKCLKETTEEIRQMG-TECHYFIC---DVG-NREEVYQTAKAVREKVGDITILVNN 123
R E L + +EI + +C DV + +V K +EK+G + +LVN
Sbjct: 62 VARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNC 121
Query: 124 AAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIP 183
A + D + + IN LG + ++A + M E + G IV ++S +
Sbjct: 122 AGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLF 181
Query: 184 GAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFP-------N 236
G Y SK + E+L + + V T P T T F P
Sbjct: 182 GFTAYSASKFAIRGLAEALQMEVKPY-NVYITVAYPPDTDTPGFAEENRTKPLETRLISE 240
Query: 237 LFPPLKPETVARRTV-EAVQLN 257
KPE VA++ V +A+Q N
Sbjct: 241 TTSVCKPEQVAKQIVKDAIQGN 262
>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
sapiens]
Length = 330
Score = 58.2 bits (139), Expect = 9e-09
Identities = 50/189 (26%), Positives = 84/189 (44%), Gaps = 8/189 (4%)
Query: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQ-MGTECHYFICDVGNR 100
+++G GIG+ A E A RG I+L R E+ L+ ++I E + D +
Sbjct: 71 VVSGATDGIGKAYAEELASRGL-NIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSG 129
Query: 101 EEVY-QTAKAVREKVGDITILVNNAAVV--HGKSLMDSDDDALLKSQHINTLGQFWTTKA 157
E+Y +A+++K D+ ILVNN V + + +D L ++N
Sbjct: 130 REIYLPIREALKDK--DVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHV 187
Query: 158 FLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTV 217
LP M+E + G IV ++S P + SKA F +L G+ ++
Sbjct: 188 VLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYAS-KGIFVQSL 246
Query: 218 LPFHTSTEM 226
+PF+ +T M
Sbjct: 247 IPFYVATSM 255
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 57.8 bits (138), Expect = 1e-08
Identities = 61/211 (28%), Positives = 91/211 (43%), Gaps = 10/211 (4%)
Query: 41 VLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEI---RQMGTECHYFICDV 97
VLI+G GIG +LA + A ++ + K+ T E +G DV
Sbjct: 8 VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67
Query: 98 GNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKA 157
+ E V Q ++ G++ +LVNNA + L A+ N G KA
Sbjct: 68 CSDESVAQCLSCIQ---GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKA 124
Query: 158 FLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTV 217
LP M + GHIV ++SV+ L + Y SK + F ESL + LL + + V
Sbjct: 125 VLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQF-NIFISLV 183
Query: 218 LPFHTSTEMFQGMRVRFPNL--FPPLKPETV 246
P TE F+G + ++ FP PET+
Sbjct: 184 EPGPVVTE-FEGKLLAQVSMAEFPGTDPETL 213
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 56.6 bits (135), Expect = 3e-08
Identities = 63/243 (25%), Positives = 103/243 (42%), Gaps = 37/243 (15%)
Query: 11 MFPLQMIYLVVKAAV-------GLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGA 63
+ PL + V AAV G P+K + + V++TG GIG+Q A E A RG
Sbjct: 5 LLPLSALGTVAGAAVLLKDYVTGGACPSKAT-IPGKTVIVTGANTGIGKQTALELARRGG 63
Query: 64 RKIVLWGRTEKCLKETTEEIRQMGTECHYFI----CDVGNREEVYQTAKAVREKVGDITI 119
I+ EKC + ++IR G ++ + D+ + + + + A + E+ + I
Sbjct: 64 NIILACRDMEKC-EAAAKDIR--GETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDI 120
Query: 120 LVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLAL 179
L+NNA V+ + +D +N LG F T L ++ I+ L+S L
Sbjct: 121 LINNAGVMRCPHW--TTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSS---L 175
Query: 180 SAIPGAID----------------YCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTS 223
+ + G ID YC SK + F + L+ L GV+ + P
Sbjct: 176 AHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKELS-RRLQGSGVTVNALHPGVAR 234
Query: 224 TEM 226
TE+
Sbjct: 235 TEL 237
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 56.2 bits (134), Expect = 3e-08
Identities = 63/219 (28%), Positives = 97/219 (44%), Gaps = 18/219 (8%)
Query: 35 DLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGT--ECHY 92
+LS + V ITG G G LA++ +RG + + C E + Q T
Sbjct: 22 NLSEKYVFITGCDSGFGNLLAKQLVDRGMQVLA------ACFTEEGSQKLQRDTSYRLQT 75
Query: 93 FICDVGNREEVYQTAKAVREKVGD--ITILVNNAAV--VHGKSLMDSDDDALLKSQHINT 148
+ DV E + A+ VR+KVG+ + LVNNA V G + + DD +K ++N
Sbjct: 76 TLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDD-FVKVINVNL 134
Query: 149 LGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLD 208
+G T LP M++ G +V ++S A+ G YC SK AF +S+ L
Sbjct: 135 VGLIEVTLHMLP-MVKRARGRVVNMSSSGGRVAVIGG-GYCVSKFGVEAFSDSIRRELYY 192
Query: 209 CPGVSATTVLPFHTSTEMF--QGMRVRFPNLFPPLKPET 245
GV + P + T + + + R L+ L ET
Sbjct: 193 F-GVKVCIIEPGNYRTAILGKENLESRMRKLWERLPQET 230
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 53.9 bits (128), Expect = 2e-07
Identities = 48/193 (24%), Positives = 79/193 (40%), Gaps = 16/193 (8%)
Query: 36 LSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIR-----QMGTEC 90
L + ++TGG GIG+ + +E E G+ ++ + E+ LK +E++
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLER-LKSAADELQANLPPTKQARV 74
Query: 91 HYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQH----I 146
C++ N EEV K+ + G I LVNN G + + K H
Sbjct: 75 IPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNG----GGQFLSPAEHISSKGWHAVLET 130
Query: 147 NTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGL 206
N G F+ KA ++ G IV + V + P A+ ++A + +SL L
Sbjct: 131 NLTGTFYMCKAVYSSWMKEHGGSIVNI-IVPTKAGFPLAVHSGAARAGVYNLTKSLALEW 189
Query: 207 LDCPGVSATTVLP 219
C G+ V P
Sbjct: 190 A-CSGIRINCVAP 201
>gi|150247226 retinol dehydrogenase 16 [Homo sapiens]
Length = 317
Score = 53.9 bits (128), Expect = 2e-07
Identities = 58/179 (32%), Positives = 81/179 (45%), Gaps = 21/179 (11%)
Query: 33 LRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKET-TEEIR-QMGTEC 90
L L + V ITG G G+ LAR+ RG R + CL E E++R Q
Sbjct: 24 LSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLA------ACLTEKGAEQLRGQTSDRL 77
Query: 91 HYFICDVGNREEVYQTAKAVREKVGDITI--LVNNAAVVHGKSLMDSDDDALLKSQ---- 144
DV E V A+ V+E V D + LVNNA G SL + ++ L K
Sbjct: 78 ETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNA----GISLPTAPNELLTKQDFVTI 133
Query: 145 -HINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESL 202
+N LG T + LP ++ G +V ++SV+ ++ G YC SK AF +SL
Sbjct: 134 LDVNLLGVIDVTLSLLP-LVRRARGRVVNVSSVMGRVSLFGG-GYCISKYGVEAFSDSL 190
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 53.1 bits (126), Expect = 3e-07
Identities = 45/193 (23%), Positives = 84/193 (43%), Gaps = 11/193 (5%)
Query: 42 LITGGGRGIGRQLAREFAERGARKIVLWGRTE---KCLKETTEEIRQMGTECHYFICDVG 98
L+TG +GIGR A +GA+ ++ E +C E+ T + CDV
Sbjct: 9 LVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTL--FIQCDVA 66
Query: 99 NREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAF 158
+++++ T + V + G + ILVNNA V + K+ + L+ ++ + + +
Sbjct: 67 DQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW-----EKTLQINLVSVISGTYLGLDY 121
Query: 159 LPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGL-LDCPGVSATTV 217
+ + + G I+ ++S+ L + YC SK F S L L GV +
Sbjct: 122 MSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAI 181
Query: 218 LPFHTSTEMFQGM 230
P +T + + +
Sbjct: 182 CPGFVNTAILESI 194
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,295,847
Number of Sequences: 37866
Number of extensions: 412247
Number of successful extensions: 1309
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 1217
Number of HSP's gapped (non-prelim): 84
length of query: 302
length of database: 18,247,518
effective HSP length: 102
effective length of query: 200
effective length of database: 14,385,186
effective search space: 2877037200
effective search space used: 2877037200
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.