Search of human proteins with 31542265

Search of human proteins with 31542265

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|31542265 tribbles 3 [Homo sapiens]
         (358 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|31542265 tribbles 3 [Homo sapiens]                                 733   0.0  
gi|11056054 tribbles homolog 2 [Homo sapiens]                         288   5e-78
gi|13399328 G-protein-coupled receptor induced protein [Homo sap...   284   8e-77
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]    110   2e-24
gi|41872374 polo-like kinase 3 [Homo sapiens]                         107   2e-23
gi|31543198 serine/threonine kinase 40 [Homo sapiens]                 106   4e-23
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]               104   1e-22
gi|212549756 calcium/calmodulin-dependent protein kinase II delt...   102   7e-22
gi|26667183 calcium/calmodulin-dependent protein kinase II delta...   102   7e-22
gi|212549753 calcium/calmodulin-dependent protein kinase II delt...   102   7e-22
gi|26667186 calcium/calmodulin-dependent protein kinase II delta...   102   7e-22
gi|26667189 calcium/calmodulin-dependent protein kinase II delta...   102   7e-22
gi|26667180 calcium/calmodulin-dependent protein kinase II delta...   102   7e-22
gi|26051204 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|26051210 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|26051214 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|26051206 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|26051216 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|26051218 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|26051212 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|26051208 calcium/calmodulin-dependent protein kinase II beta ...   100   3e-21
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]              100   3e-21
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun...    99   4e-21
gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]           98   1e-20
gi|25952118 calcium/calmodulin-dependent protein kinase II alpha...    96   6e-20
gi|25952114 calcium/calmodulin-dependent protein kinase II alpha...    96   6e-20
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca...    94   2e-19
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca...    94   2e-19
gi|116256471 SNF1-like kinase [Homo sapiens]                           93   3e-19
gi|26667199 calcium/calmodulin-dependent protein kinase II gamma...    92   5e-19

>gi|31542265 tribbles 3 [Homo sapiens]
          Length = 358

 Score =  733 bits (1891), Expect = 0.0
 Identities = 358/358 (100%), Positives = 358/358 (100%)

Query: 1   MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRAT 60
           MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRAT
Sbjct: 1   MRATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRAT 60

Query: 61  AVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHV 120
           AVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHV
Sbjct: 61  AVATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHV 120

Query: 121 ARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVL 180
           ARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVL
Sbjct: 121 ARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVL 180

Query: 181 RDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGK 240
           RDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGK
Sbjct: 181 RDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGK 240

Query: 241 AADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREP 300
           AADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREP
Sbjct: 241 AADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREP 300

Query: 301 AERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG 358
           AERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG
Sbjct: 301 AERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPDGLGLDEAREEEGDREVVLYG 358


>gi|11056054 tribbles homolog 2 [Homo sapiens]
          Length = 343

 Score =  288 bits (737), Expect = 5e-78
 Identities = 154/317 (48%), Positives = 201/317 (63%), Gaps = 10/317 (3%)

Query: 2   RATPLAAPAGSLSRKKRLELDDNLDTERPVQKRARSGPQPRLPPCLLPLSPPTAPDRATA 61
           R+TP+       SR K  + ++ L + R  +      P     P L   SPP  P+ +  
Sbjct: 5   RSTPITIARYGRSRNKTQDFEE-LSSIRSAE------PSQSFSPNLGSPSPPETPNLSHC 57

Query: 62  VATASRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVA 121
           V   S +G Y+LLEP EG   ++A+H  +G E  CKV+ +      L P   L  H ++ 
Sbjct: 58  V---SCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFDISCYQESLAPCFCLSAHSNIN 114

Query: 122 RPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLR 181
           + TE++ G    Y FF R++GDMHS VR+  ++ E EAA LF Q+A+A+AHCH  GLVLR
Sbjct: 115 QITEIILGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIASAVAHCHDGGLVLR 174

Query: 182 DLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKA 241
           DLKL +F+F D ER ++ LE+LED+ +L G DDSL DKH CPAYV PEIL++  SYSGKA
Sbjct: 175 DLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAYVSPEILNTSGSYSGKA 234

Query: 242 ADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPA 301
           ADVWSLGV L+TML G YPF D EP  LF KIRRG + +P  LS  A+CL+R +LRREP+
Sbjct: 235 ADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPS 294

Query: 302 ERLTATGILLHPWLRQD 318
           ERLT+  IL HPW   D
Sbjct: 295 ERLTSQEILDHPWFSTD 311


>gi|13399328 G-protein-coupled receptor induced protein [Homo
           sapiens]
          Length = 372

 Score =  284 bits (727), Expect = 8e-77
 Identities = 149/297 (50%), Positives = 191/297 (64%), Gaps = 5/297 (1%)

Query: 45  PCLLPLSPPTAPDRATAVATA---SRLGPYVLLEPEEGGRAYQALHCPTGTEYTCKVYPV 101
           PC  P  PP AP       +A   SR+  Y+LL   E     +AL   TG E  CKV+P+
Sbjct: 66  PCS-PQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPI 124

Query: 102 QEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAV 161
           +     + PY +LP H ++    EV+ G    Y FF +  GDMHS VRSR R+ E EAA 
Sbjct: 125 KHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAAR 184

Query: 162 LFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHA 221
           LF+Q+ +A+AHCHQ  +VL DLKL +FVF+  ER +L LE+LED+ ++ G DD+L DKH 
Sbjct: 185 LFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHG 244

Query: 222 CPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALP 281
           CPAYV PEIL++  +YSGKAADVWSLGV L+T+L G YPF DS+P  LF KIRRG + +P
Sbjct: 245 CPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIP 304

Query: 282 AGLSAPARCLVRCLLRREPAERLTATGILLHPWLRQDPMPLAPTRSHLWEAAQVVPD 338
             +S  ARCL+R LLRREP+ERLTA  ILLHPW      P     S +  + Q+VP+
Sbjct: 305 EHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEP-GYIDSEIGTSDQIVPE 360


>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
          Length = 651

 Score =  110 bits (275), Expect = 2e-24
 Identities = 64/205 (31%), Positives = 107/205 (52%), Gaps = 7/205 (3%)

Query: 117 HKHVARPTEVLAGTQLLYAFFTRTHG-DMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQ 175
           H+H+ +   VL     ++       G ++   + S+ R+ E E  V+FRQ+ +A+A+ H 
Sbjct: 66  HQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHS 125

Query: 176 HGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACP--AYVGPEILSS 233
            G   RDLK    +F +  + KL+   L   C     +     +  C   AY  PE++  
Sbjct: 126 QGYAHRDLKPENLLFDEYHKLKLIDFGL---CAKPKGNKDYHLQTCCGSLAYAAPELIQG 182

Query: 234 RASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVR 293
           + SY G  ADVWS+G+ L+ ++ G  PF D   + L+ KI RG Y +P  LS  +  L++
Sbjct: 183 K-SYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQ 241

Query: 294 CLLRREPAERLTATGILLHPWLRQD 318
            +L+ +P +R++   +L HPW+ QD
Sbjct: 242 QMLQVDPKKRISMKNLLNHPWIMQD 266


>gi|41872374 polo-like kinase 3 [Homo sapiens]
          Length = 646

 Score =  107 bits (267), Expect = 2e-23
 Identities = 76/253 (30%), Positives = 117/253 (46%), Gaps = 19/253 (7%)

Query: 81  RAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLP-----------PHKHVARPTEVLAG 129
           R Y+A    TG+ Y  KV P      V +P+ R              H+H+ R +     
Sbjct: 75  RCYEATDTETGSAYAVKVIPQSR---VAKPHQREKILNEIELHRDLQHRHIVRFSHHFED 131

Query: 130 TQLLYAFFTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRF 188
              +Y F    +   +  + ++RH + EPE     RQ+ + L + HQ G++ RDLKL  F
Sbjct: 132 ADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNF 191

Query: 189 VFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLG 248
                E  +L + +   +  L  P+         P YV PE+L  +    G  ADVWSLG
Sbjct: 192 FIT--ENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGH--GPEADVWSLG 247

Query: 249 VALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATG 308
             ++T+L G  PF+ ++    +  I++  Y LPA LS PAR L+  +LR  P +R +   
Sbjct: 248 CVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQ 307

Query: 309 ILLHPWLRQDPMP 321
           IL H +  +   P
Sbjct: 308 ILRHDFFTKGYTP 320


>gi|31543198 serine/threonine kinase 40 [Homo sapiens]
          Length = 435

 Score =  106 bits (264), Expect = 4e-23
 Identities = 63/168 (37%), Positives = 92/168 (54%), Gaps = 5/168 (2%)

Query: 145 HSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLE 204
           H +++ + R+ E E  V+F  +   +   HQ  +V RDLKL   V  ++   ++ + N  
Sbjct: 161 HYVIKEK-RLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVL-NKRTHRITITNFC 218

Query: 205 DSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDS 264
               L    D L D+   PAY+ P++LS R  Y GK +D+W+LGV LFTML G +PF DS
Sbjct: 219 LGKHLVSEGDLLKDQRGSPAYISPDVLSGR-PYRGKPSDMWALGVVLFTMLYGQFPFYDS 277

Query: 265 EPVLLFGKIRRGAYALP--AGLSAPARCLVRCLLRREPAERLTATGIL 310
            P  LF KI+   Y +P    +S    CL+R LL  +P +RL A  +L
Sbjct: 278 IPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVL 325


>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
          Length = 778

 Score =  104 bits (259), Expect = 1e-22
 Identities = 80/286 (27%), Positives = 122/286 (42%), Gaps = 29/286 (10%)

Query: 44  PPCLLPLSPPTAPDRATAVATASRLGPYVL---LEPEEGGRAYQALHCPTGTEYTCKVY- 99
           P   LP   P  P  A  V      GPY L   L   + G     +HC TG +   K+  
Sbjct: 13  PAYHLPHPHPHPPQHAQYV------GPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVN 66

Query: 100 ----------PVQEALAVLEPYARLPPHKHVARPTEVLAGTQLLYAFFTRTHG-DMHSLV 148
                      V+  +A+L    +L  H HV +  +V    + LY       G ++   +
Sbjct: 67  REKLSESVLMKVEREIAIL----KLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYL 122

Query: 149 RSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCV 208
             + R+   EA   FRQ+ +AL  CH + +  RDLK    +  ++   ++    +     
Sbjct: 123 VKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMAS--- 179

Query: 209 LTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVL 268
           L   D  L      P Y  PE++     Y G+ AD+WS GV LF +L G  PF D     
Sbjct: 180 LQVGDSLLETSCGSPHYACPEVIKGE-KYDGRRADMWSCGVILFALLVGALPFDDDNLRQ 238

Query: 269 LFGKIRRGAYALPAGLSAPARCLVRCLLRREPAERLTATGILLHPW 314
           L  K++RG + +P  +    + L+R ++  EP +RL+   I  HPW
Sbjct: 239 LLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW 284


>gi|212549756 calcium/calmodulin-dependent protein kinase II delta
           isoform 4 [Homo sapiens]
          Length = 489

 Score =  102 bits (253), Expect = 7e-22
 Identities = 72/247 (29%), Positives = 123/247 (49%), Gaps = 15/247 (6%)

Query: 84  QALHCPTGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAF 136
           + +  PTG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  
Sbjct: 30  RCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV 89

Query: 137 FTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER 195
           F   T G++   + +R    E +A+   +Q+  ++ HCH +G+V RDLK    + A + +
Sbjct: 90  FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK 149

Query: 196 KKLV-LENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTM 254
              V L +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +
Sbjct: 150 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDMWACGVILYIL 207

Query: 255 LAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGIL 310
           L G+ PF D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA+  L
Sbjct: 208 LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEAL 267

Query: 311 LHPWLRQ 317
            HPW+ Q
Sbjct: 268 KHPWICQ 274


>gi|26667183 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  102 bits (253), Expect = 7e-22
 Identities = 72/247 (29%), Positives = 123/247 (49%), Gaps = 15/247 (6%)

Query: 84  QALHCPTGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAF 136
           + +  PTG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  
Sbjct: 30  RCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV 89

Query: 137 FTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER 195
           F   T G++   + +R    E +A+   +Q+  ++ HCH +G+V RDLK    + A + +
Sbjct: 90  FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK 149

Query: 196 KKLV-LENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTM 254
              V L +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +
Sbjct: 150 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDMWACGVILYIL 207

Query: 255 LAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGIL 310
           L G+ PF D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA+  L
Sbjct: 208 LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEAL 267

Query: 311 LHPWLRQ 317
            HPW+ Q
Sbjct: 268 KHPWICQ 274


>gi|212549753 calcium/calmodulin-dependent protein kinase II delta
           isoform 5 [Homo sapiens]
          Length = 492

 Score =  102 bits (253), Expect = 7e-22
 Identities = 72/247 (29%), Positives = 123/247 (49%), Gaps = 15/247 (6%)

Query: 84  QALHCPTGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAF 136
           + +  PTG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  
Sbjct: 30  RCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV 89

Query: 137 FTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER 195
           F   T G++   + +R    E +A+   +Q+  ++ HCH +G+V RDLK    + A + +
Sbjct: 90  FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK 149

Query: 196 KKLV-LENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTM 254
              V L +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +
Sbjct: 150 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDMWACGVILYIL 207

Query: 255 LAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGIL 310
           L G+ PF D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA+  L
Sbjct: 208 LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEAL 267

Query: 311 LHPWLRQ 317
            HPW+ Q
Sbjct: 268 KHPWICQ 274


>gi|26667186 calcium/calmodulin-dependent protein kinase II delta
           isoform 1 [Homo sapiens]
          Length = 478

 Score =  102 bits (253), Expect = 7e-22
 Identities = 72/247 (29%), Positives = 123/247 (49%), Gaps = 15/247 (6%)

Query: 84  QALHCPTGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAF 136
           + +  PTG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  
Sbjct: 30  RCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV 89

Query: 137 FTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER 195
           F   T G++   + +R    E +A+   +Q+  ++ HCH +G+V RDLK    + A + +
Sbjct: 90  FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK 149

Query: 196 KKLV-LENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTM 254
              V L +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +
Sbjct: 150 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDMWACGVILYIL 207

Query: 255 LAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGIL 310
           L G+ PF D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA+  L
Sbjct: 208 LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEAL 267

Query: 311 LHPWLRQ 317
            HPW+ Q
Sbjct: 268 KHPWICQ 274


>gi|26667189 calcium/calmodulin-dependent protein kinase II delta
           isoform 2 [Homo sapiens]
          Length = 478

 Score =  102 bits (253), Expect = 7e-22
 Identities = 72/247 (29%), Positives = 123/247 (49%), Gaps = 15/247 (6%)

Query: 84  QALHCPTGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAF 136
           + +  PTG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  
Sbjct: 30  RCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV 89

Query: 137 FTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER 195
           F   T G++   + +R    E +A+   +Q+  ++ HCH +G+V RDLK    + A + +
Sbjct: 90  FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK 149

Query: 196 KKLV-LENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTM 254
              V L +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +
Sbjct: 150 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDMWACGVILYIL 207

Query: 255 LAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGIL 310
           L G+ PF D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA+  L
Sbjct: 208 LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEAL 267

Query: 311 LHPWLRQ 317
            HPW+ Q
Sbjct: 268 KHPWICQ 274


>gi|26667180 calcium/calmodulin-dependent protein kinase II delta
           isoform 3 [Homo sapiens]
          Length = 499

 Score =  102 bits (253), Expect = 7e-22
 Identities = 72/247 (29%), Positives = 123/247 (49%), Gaps = 15/247 (6%)

Query: 84  QALHCPTGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAF 136
           + +  PTG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  
Sbjct: 30  RCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLV 89

Query: 137 FTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRER 195
           F   T G++   + +R    E +A+   +Q+  ++ HCH +G+V RDLK    + A + +
Sbjct: 90  FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK 149

Query: 196 KKLV-LENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTM 254
              V L +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +
Sbjct: 150 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDMWACGVILYIL 207

Query: 255 LAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGIL 310
           L G+ PF D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA+  L
Sbjct: 208 LVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEAL 267

Query: 311 LHPWLRQ 317
            HPW+ Q
Sbjct: 268 KHPWICQ 274


>gi|26051204 calcium/calmodulin-dependent protein kinase II beta
           isoform 1 [Homo sapiens]
          Length = 666

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|26051210 calcium/calmodulin-dependent protein kinase II beta
           isoform 4 [Homo sapiens]
          Length = 517

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|26051214 calcium/calmodulin-dependent protein kinase II beta
           isoform 6 [Homo sapiens]
          Length = 492

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|26051206 calcium/calmodulin-dependent protein kinase II beta
           isoform 2 [Homo sapiens]
          Length = 542

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|26051216 calcium/calmodulin-dependent protein kinase II beta
           isoform 7 [Homo sapiens]
          Length = 479

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|26051218 calcium/calmodulin-dependent protein kinase II beta
           isoform 8 [Homo sapiens]
          Length = 449

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|26051212 calcium/calmodulin-dependent protein kinase II beta
           isoform 5 [Homo sapiens]
          Length = 503

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|26051208 calcium/calmodulin-dependent protein kinase II beta
           isoform 3 [Homo sapiens]
          Length = 518

 Score =  100 bits (248), Expect = 3e-21
 Identities = 73/241 (30%), Positives = 119/241 (49%), Gaps = 15/241 (6%)

Query: 90  TGTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-TH 141
           TG EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T 
Sbjct: 36  TGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTG 95

Query: 142 GDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-L 200
           G++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L
Sbjct: 96  GELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKL 155

Query: 201 ENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYP 260
            +   +  + G   + +     P Y+ PE+L   A   GK  D+W+ GV L+ +L G+ P
Sbjct: 156 ADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAY--GKPVDIWACGVILYILLVGYPP 213

Query: 261 FQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWLR 316
           F D +   L+ +I+ GAY  P+     ++  A+ L+  +L   PA+R+TA   L HPW+ 
Sbjct: 214 FWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 273

Query: 317 Q 317
           Q
Sbjct: 274 Q 274


>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
          Length = 668

 Score = 99.8 bits (247), Expect = 3e-21
 Identities = 77/278 (27%), Positives = 119/278 (42%), Gaps = 26/278 (9%)

Query: 65  ASRLGPYVL---LEPEEGGRAYQALHCPTGTEYTCKVY-----------PVQEALAVLEP 110
           A  +GPY L   L   + G     +HC T  +   K+             V+  +A+L  
Sbjct: 13  AQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAIL-- 70

Query: 111 YARLPPHKHVARPTEVLAGTQLLYAFFTRTHG-DMHSLVRSRHRIPEPEAAVLFRQMATA 169
             +L  H HV +  +V    + LY       G ++   +  + R+   EA   FRQ+ +A
Sbjct: 71  --KLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISA 128

Query: 170 LAHCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPE 229
           L  CH H +  RDLK    +  ++   ++    +     L   D  L      P Y  PE
Sbjct: 129 LDFCHSHSICHRDLKPENLLLDEKNNIRIADFGMAS---LQVGDSLLETSCGSPHYACPE 185

Query: 230 ILSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPAR 289
           ++     Y G+ ADVWS GV LF +L G  PF D     L  K++RG + +P  +    +
Sbjct: 186 VIRGE-KYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQ 244

Query: 290 CLVRCLLRREPAERLTATGILLHPWL---RQDPMPLAP 324
            L+R ++  + A RLT   I  H W    + +P P  P
Sbjct: 245 SLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPEPEQP 282


>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
           [Homo sapiens]
          Length = 552

 Score = 99.4 bits (246), Expect = 4e-21
 Identities = 61/203 (30%), Positives = 98/203 (48%), Gaps = 5/203 (2%)

Query: 117 HKHVARPTEVLAG-TQLLYAFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQ 175
           H H+ +  +V++  T         + G++   +    R+ E EA  LF+Q+ +A+ +CH+
Sbjct: 73  HPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHR 132

Query: 176 HGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRA 235
           H +V RDLK    +       K+    L +   +    + L      P Y  PE++S R 
Sbjct: 133 HMVVHRDLKPENVLLDAHMNAKIADFGLSN---MMSDGEFLRTSCGSPNYAAPEVISGRL 189

Query: 236 SYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLVRCL 295
            Y+G   D+WS GV L+ +L G  PF D     LF KIR G + +P  L+     L+  +
Sbjct: 190 -YAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHM 248

Query: 296 LRREPAERLTATGILLHPWLRQD 318
           L+ +P +R T   I  H W +QD
Sbjct: 249 LQVDPLKRATIKDIREHEWFKQD 271


>gi|4507271 serine/threonine protein kinase 11 [Homo sapiens]
          Length = 433

 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 69/245 (28%), Positives = 108/245 (44%), Gaps = 12/245 (4%)

Query: 117 HKHVARPTEVLAGT--QLLYAFFTRTHGDMHSLVRS--RHRIPEPEAAVLFRQMATALAH 172
           HK+V +  +VL     Q +Y         M  ++ S    R P  +A   F Q+   L +
Sbjct: 107 HKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEY 166

Query: 173 CHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILS 232
            H  G+V +D+K    +       K+    + ++      DD+       PA+  PEI +
Sbjct: 167 LHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIAN 226

Query: 233 SRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCLV 292
              ++SG   D+WS GV L+ +  G YPF+      LF  I +G+YA+P     P   L+
Sbjct: 227 GLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLL 286

Query: 293 RCLLRREPAERLTATGILLHPWLRQD--------PMPLAPTRSHLWEAAQVVPDGLGLDE 344
           + +L  EPA+R +   I  H W R+         P+P +P     W +  VVP    L  
Sbjct: 287 KGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHG 346

Query: 345 AREEE 349
           A E+E
Sbjct: 347 ADEDE 351


>gi|25952118 calcium/calmodulin-dependent protein kinase II alpha
           isoform 2 [Homo sapiens]
          Length = 478

 Score = 95.5 bits (236), Expect = 6e-20
 Identities = 70/238 (29%), Positives = 117/238 (49%), Gaps = 15/238 (6%)

Query: 91  GTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-THG 142
           G EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T G
Sbjct: 36  GQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGG 95

Query: 143 DMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-LE 201
           ++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L 
Sbjct: 96  ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLA 155

Query: 202 NLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPF 261
           +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +L G+ PF
Sbjct: 156 DFGLAIEVEGEQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDLWACGVILYILLVGYPPF 213

Query: 262 QDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWL 315
            D +   L+ +I+ GAY  P+     ++  A+ L+  +L   P++R+TA   L HPW+
Sbjct: 214 WDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271


>gi|25952114 calcium/calmodulin-dependent protein kinase II alpha
           isoform 1 [Homo sapiens]
          Length = 489

 Score = 95.5 bits (236), Expect = 6e-20
 Identities = 70/238 (29%), Positives = 117/238 (49%), Gaps = 15/238 (6%)

Query: 91  GTEYTCKVYPVQEALA----VLEPYAR---LPPHKHVARPTEVLAGTQLLYAFFTR-THG 142
           G EY  K+   ++  A     LE  AR   L  H ++ R  + ++     Y  F   T G
Sbjct: 36  GQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGG 95

Query: 143 DMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVFADRERKKLV-LE 201
           ++   + +R    E +A+   +Q+  A+ HCHQ G+V RDLK    + A + +   V L 
Sbjct: 96  ELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLA 155

Query: 202 NLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGVALFTMLAGHYPF 261
           +   +  + G   + +     P Y+ PE+L  R    GK  D+W+ GV L+ +L G+ PF
Sbjct: 156 DFGLAIEVEGEQQAWFGFAGTPGYLSPEVL--RKDPYGKPVDLWACGVILYILLVGYPPF 213

Query: 262 QDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLTATGILLHPWL 315
            D +   L+ +I+ GAY  P+     ++  A+ L+  +L   P++R+TA   L HPW+
Sbjct: 214 WDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271


>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform b [Homo sapiens]
          Length = 360

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 77/253 (30%), Positives = 116/253 (45%), Gaps = 14/253 (5%)

Query: 72  VLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQ 131
           V+L  E G     AL C        K   V+  +AVL    R   H ++    +V     
Sbjct: 46  VVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVL----RRISHPNIVALEDVHESPS 101

Query: 132 LLY-AFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVF 190
            LY A    T G++   +  R    E +A+ L  Q+  A+++ H  G+V RDLK    ++
Sbjct: 102 HLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLY 161

Query: 191 ADR-ERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGV 249
           A   E  K+++ +   S +  G  + L      P YV PE+L  +    GKA DVW+LGV
Sbjct: 162 ATPFEDSKIMVSDFGLSKIQAG--NMLGTACGTPGYVAPELLEQKPY--GKAVDVWALGV 217

Query: 250 ALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLT 305
             + +L G+ PF D     LF +I R +Y   +     +S  A+  +R LL R+P +R T
Sbjct: 218 ISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFT 277

Query: 306 ATGILLHPWLRQD 318
               L H W+  D
Sbjct: 278 CQQALRHLWISGD 290


>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
           kinase isoform a [Homo sapiens]
          Length = 426

 Score = 94.0 bits (232), Expect = 2e-19
 Identities = 77/253 (30%), Positives = 116/253 (45%), Gaps = 14/253 (5%)

Query: 72  VLLEPEEGGRAYQALHCPTGTEYTCKVYPVQEALAVLEPYARLPPHKHVARPTEVLAGTQ 131
           V+L  E G     AL C        K   V+  +AVL    R   H ++    +V     
Sbjct: 112 VVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVL----RRISHPNIVALEDVHESPS 167

Query: 132 LLY-AFFTRTHGDMHSLVRSRHRIPEPEAAVLFRQMATALAHCHQHGLVLRDLKLCRFVF 190
            LY A    T G++   +  R    E +A+ L  Q+  A+++ H  G+V RDLK    ++
Sbjct: 168 HLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLY 227

Query: 191 ADR-ERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEILSSRASYSGKAADVWSLGV 249
           A   E  K+++ +   S +  G  + L      P YV PE+L  +    GKA DVW+LGV
Sbjct: 228 ATPFEDSKIMVSDFGLSKIQAG--NMLGTACGTPGYVAPELLEQKPY--GKAVDVWALGV 283

Query: 250 ALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSAPARCLVRCLLRREPAERLT 305
             + +L G+ PF D     LF +I R +Y   +     +S  A+  +R LL R+P +R T
Sbjct: 284 ISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFT 343

Query: 306 ATGILLHPWLRQD 318
               L H W+  D
Sbjct: 344 CQQALRHLWISGD 356


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 71/250 (28%), Positives = 109/250 (43%), Gaps = 17/250 (6%)

Query: 113 RLPPHKHVARPTEVLAGTQLLYAFFT-RTHGDMHSLVRSRHRIPEPEAAVLFRQMATALA 171
           +L  H H+ +  +V+    +LY       +G+M   + S   + E EA   F Q+ +A+ 
Sbjct: 79  KLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVE 138

Query: 172 HCHQHGLVLRDLKLCRFVFADRERKKLVLENLEDSCVLTGPDDSLWDKHACPAYVGPEIL 231
           +CH H +V RDLK    +       KL       +   +G   S W     P Y  PE+ 
Sbjct: 139 YCHDHHIVHRDLKTENLLLDGNMDIKLADFGF-GNFYKSGEPLSTWC--GSPPYAAPEVF 195

Query: 232 SSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPAGLSAPARCL 291
             +  Y G   D+WSLGV L+ ++ G  PF       L  ++  G + +P  +S     L
Sbjct: 196 EGK-EYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESL 254

Query: 292 VRCLLRREPAERLTATGILLHPWLRQDPM---PLAPTRS-HLW--------EAAQVVPDG 339
           +R +L  +PA R+T   I  H W+R +P    P  P  S H +        E A  +   
Sbjct: 255 IRRMLVVDPARRITIAQIRQHRWMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQT 314

Query: 340 LGLDEAREEE 349
           LG+D  R  E
Sbjct: 315 LGVDRQRTVE 324


>gi|26667199 calcium/calmodulin-dependent protein kinase II gamma
           isoform 3 [Homo sapiens]
          Length = 518

 Score = 92.4 bits (228), Expect = 5e-19
 Identities = 62/211 (29%), Positives = 105/211 (49%), Gaps = 8/211 (3%)

Query: 113 RLPPHKHVARPTEVLAGTQLLYAFFTR-THGDMHSLVRSRHRIPEPEAAVLFRQMATALA 171
           RL  H ++ R  + ++     Y  F   T G++   + +R    E +A+    Q+  ++ 
Sbjct: 66  RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVN 125

Query: 172 HCHQHGLVLRDLKLCRFVFADRERKKLV-LENLEDSCVLTGPDDSLWDKHACPAYVGPEI 230
           H HQH +V RDLK    + A + +   V L +   +  + G   + +     P Y+ PE+
Sbjct: 126 HIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEV 185

Query: 231 LSSRASYSGKAADVWSLGVALFTMLAGHYPFQDSEPVLLFGKIRRGAYALPA----GLSA 286
           L  R    GK  D+W+ GV L+ +L G+ PF D +   L+ +I+ GAY  P+     ++ 
Sbjct: 186 L--RKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTP 243

Query: 287 PARCLVRCLLRREPAERLTATGILLHPWLRQ 317
            A+ L+  +L   PA+R+TA   L HPW+ Q
Sbjct: 244 EAKNLINQMLTINPAKRITADQALKHPWVCQ 274


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,049,515
Number of Sequences: 37866
Number of extensions: 813112
Number of successful extensions: 4239
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 308
Number of HSP's successfully gapped in prelim test: 229
Number of HSP's that attempted gapping in prelim test: 3344
Number of HSP's gapped (non-prelim): 692
length of query: 358
length of database: 18,247,518
effective HSP length: 103
effective length of query: 255
effective length of database: 14,347,320
effective search space: 3658566600
effective search space used: 3658566600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.