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Search of human proteins with 31541941
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]
(839 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens] 1676 0.0
gi|38327039 heat shock 70kDa protein 4 [Homo sapiens] 1088 0.0
gi|42544159 heat shock 105kD [Homo sapiens] 992 0.0
gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens] 304 2e-82
gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens] 304 2e-82
gi|124256496 heat shock 70kDa protein 1-like [Homo sapiens] 278 1e-74
gi|167466173 heat shock 70kDa protein 1B [Homo sapiens] 275 1e-73
gi|194248072 heat shock 70kDa protein 1A [Homo sapiens] 275 1e-73
gi|34419635 heat shock 70kDa protein 6 (HSP70B') [Homo sapiens] 269 9e-72
gi|5729877 heat shock 70kDa protein 8 isoform 1 [Homo sapiens] 268 1e-71
gi|24234686 heat shock 70kDa protein 8 isoform 2 [Homo sapiens] 261 2e-69
gi|13676857 heat shock 70kDa protein 2 [Homo sapiens] 258 2e-68
gi|16507237 heat shock 70kDa protein 5 [Homo sapiens] 252 1e-66
gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens] 226 5e-59
gi|82880658 heat shock 70kDa protein 14 isoform 1 [Homo sapiens] 189 1e-47
gi|48928056 heat shock protein 70kDa family member 13 precursor ... 149 1e-35
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 49 2e-05
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 48 4e-05
gi|5454102 transforming, acidic coiled-coil containing protein 3... 39 0.020
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 39 0.020
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 39 0.020
gi|110349719 titin isoform N2-A [Homo sapiens] 38 0.034
gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo ... 38 0.045
gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo ... 38 0.045
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 37 0.058
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 37 0.076
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 37 0.100
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 37 0.100
gi|118498362 kinectin 1 isoform b [Homo sapiens] 37 0.100
gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo sap... 37 0.100
>gi|31541941 heat shock 70kDa protein 4-like [Homo sapiens]
Length = 839
Score = 1676 bits (4340), Expect = 0.0
Identities = 839/839 (100%), Positives = 839/839 (100%)
Query: 1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV 60
MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV
Sbjct: 1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV 60
Query: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM 120
RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM
Sbjct: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM 120
Query: 121 LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA 180
LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA
Sbjct: 121 LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA 180
Query: 181 YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL 240
YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL
Sbjct: 181 YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL 240
Query: 241 VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSK 300
VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSK
Sbjct: 241 VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSK 300
Query: 301 MNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLK 360
MNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLK
Sbjct: 301 MNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLK 360
Query: 361 DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF
Sbjct: 361 DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
Query: 421 CKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKV 480
CKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKV
Sbjct: 421 CKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKV 480
Query: 481 KVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKC 540
KVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKC
Sbjct: 481 KVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKC 540
Query: 541 HAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSY 600
HAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSY
Sbjct: 541 HAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSY 600
Query: 601 IENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTEN 660
IENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTEN
Sbjct: 601 IENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTEN 660
Query: 661 WLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYR 720
WLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYR
Sbjct: 661 WLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYR 720
Query: 721 NKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDN 780
NKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDN
Sbjct: 721 NKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDN 780
Query: 781 FCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQSGTETKSDSTKDSSQHTKSSGEMEVD 839
FCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQSGTETKSDSTKDSSQHTKSSGEMEVD
Sbjct: 781 FCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQSGTETKSDSTKDSSQHTKSSGEMEVD 839
>gi|38327039 heat shock 70kDa protein 4 [Homo sapiens]
Length = 840
Score = 1088 bits (2813), Expect = 0.0
Identities = 541/853 (63%), Positives = 669/853 (78%), Gaps = 27/853 (3%)
Query: 1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV 60
MSVVGIDLGF +CY+AVAR+GGIETIANEYSDRCTPACIS G + R+IG AAKSQ+++N
Sbjct: 1 MSVVGIDLGFQSCYVAVARAGGIETIANEYSDRCTPACISFGPKNRSIGAAAKSQVISNA 60
Query: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM 120
+NT+ GFK+ HGR+F DP V+ E+ L Y++ ++P G G+KV Y+EEER F EQVT M
Sbjct: 61 KNTVQGFKRFHGRAFSDPFVEAEKSNLAYDIVQLPTGLTGIKVTYMEEERNFTTEQVTAM 120
Query: 121 LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA 180
LL+KLKET+E+ LKKPV DCV+S+P F+TDAERRSVM A Q+AGLNCLRLMNETTAVALA
Sbjct: 121 LLSKLKETAESVLKKPVVDCVVSVPCFYTDAERRSVMDATQIAGLNCLRLMNETTAVALA 180
Query: 181 YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL 240
YGIYKQDLP L+EKPRNVVF+DMGHSAYQV VCAFN+GKLKVLAT FD LGGR FDE L
Sbjct: 181 YGIYKQDLPALEEKPRNVVFVDMGHSAYQVSVCAFNRGKLKVLATAFDTTLGGRKFDEVL 240
Query: 241 VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSK 300
V++FC+EF KYK+++K RALLRL QECEKLKKLMSANASDLPL+IECFMND+DVS
Sbjct: 241 VNHFCEEFGKKYKLDIKSKIRALLRLSQECEKLKKLMSANASDLPLSIECFMNDVDVSGT 300
Query: 301 MNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLK 360
MNR +F ++C LLARVEPPL++V+EQ L++EDI ++EIVGGATRIPAVKE+I+KFF K
Sbjct: 301 MNRGKFLEMCNDLLARVEPPLRSVLEQTKLKKEDIYAVEIVGGATRIPAVKEKISKFFGK 360
Query: 361 DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
++STTLNADEAV RGCALQCAILSPAFKVREFSITD+VPY I+LRW + E+GS +CEVF
Sbjct: 361 ELSTTLNADEAVTRGCALQCAILSPAFKVREFSITDVVPYPISLRWNSPAEEGSSDCEVF 420
Query: 421 CKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKV 480
KNH APFSKV+TF++KEPF LEA+Y++ ++PYPD I F++Q V PQSDG SSKVKV
Sbjct: 421 SKNHAAPFSKVLTFYRKEPFTLEAYYSSPQDLPYPDPAIAQFSVQKVTPQSDGSSSKVKV 480
Query: 481 KVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKC 540
KVRVN+HGIFSV+SAS++E + + ++ PMET+ + K E +KMQVDQEE H +
Sbjct: 481 KVRVNVHGIFSVSSASLVEVH--KSEENEEPMETDQNAKEE-----EKMQVDQEEPHVEE 533
Query: 541 HAEHTPEEEIDHTGAKTKSAVSDKQDRLNQ--TLKKGKVK--SIDLPIQSSLCRQLGQDL 596
+ TP E + S K +++Q KK KVK ++DLPI++ L Q+ +++
Sbjct: 534 QQQQTPAENKAESEEMETSQAGSKDKKMDQPPQAKKAKVKTSTVDLPIENQLLWQIDREM 593
Query: 597 LNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLE 656
LN YIENEGKMIMQDKLEKERNDAKNAVEEYVY+ RD+L YEKF++ +D + + LE
Sbjct: 594 LNLYIENEGKMIMQDKLEKERNDAKNAVEEYVYEMRDKLSGEYEKFVSEDDRNSFTLKLE 653
Query: 657 DTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVI 716
DTENWLYEDGEDQPKQVYVDKL ELK GQPI++++ E EERPK +LGK+IQ MK+I
Sbjct: 654 DTENWLYEDGEDQPKQVYVDKLAELKNLGQPIKIRFQESEERPKLFEELGKQIQQYMKII 713
Query: 717 EAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSK 776
+++NK+++YDHLD +M KVEK ++AM W+N+K+N QNK SLT DPVVK EI AK K
Sbjct: 714 SSFKNKEDQYDHLDAADMTKVEKSTNEAMEWMNNKLNLQNKQSLTMDPVVKSKEIEAKIK 773
Query: 777 ELDNFCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQ----------SGTETKSDSTKDS 826
EL + C+PII KPKPK E P+++ K N+E NGP+DGQ GT+T S D
Sbjct: 774 ELTSTCSPIISKPKPKVEPPKEEQK-NAEQNGPVDGQGDNPGPQAAEQGTDTAVPSDSD- 831
Query: 827 SQHTKSSGEMEVD 839
K EM++D
Sbjct: 832 ----KKLPEMDID 840
>gi|42544159 heat shock 105kD [Homo sapiens]
Length = 858
Score = 992 bits (2564), Expect = 0.0
Identities = 499/823 (60%), Positives = 624/823 (75%), Gaps = 18/823 (2%)
Query: 1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV 60
MSVVG+D+G +CYIAVAR+GGIETIANE+SDRCTP+ IS GS+ R IG AAK+Q +T+
Sbjct: 1 MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHA 60
Query: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM 120
NT+ FK+ HGR+F+DP +Q E+ L Y+L + NG G+KV Y+ EE F++EQ+T M
Sbjct: 61 NNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITAM 120
Query: 121 LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA 180
LL KLKET+EN+LKKPV DCVIS+PSFFTDAERRSV+ AAQ+ GLNCLRLMN+ TAVAL
Sbjct: 121 LLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALN 180
Query: 181 YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL 240
YGIYKQDLP LDEKPR VVF+DMGHSA+QV CAFNKGKLKVL T FDP+LGG+NFDE L
Sbjct: 181 YGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKL 240
Query: 241 VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSK 300
V++FC EFKTKYK++ K RALLRLYQECEKLKKLMS+N++DLPLNIECFMND DVS K
Sbjct: 241 VEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGK 300
Query: 301 MNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLK 360
MNR+QFE+LCA LL ++E PL +++EQ +L+ ED+S++EIVGGATRIPAVKE+I KFF K
Sbjct: 301 MNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGK 360
Query: 361 DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
DISTTLNADEAVARGCALQCAILSPAFKVREFS+TD VP+ I+L W ED G EVF
Sbjct: 361 DISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVF 420
Query: 421 CKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKV 480
+NH APFSKV+TF ++ PFELEAFY++ VPYP+A+IG F +QNV Q DG+ S+VKV
Sbjct: 421 SRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKV 480
Query: 481 KVRVNIHGIFSVASASVIEKQNLEGDH--SDAPMETETSFKNENKDNMDKMQVDQEEG-- 536
KVRVN HGIF++++AS++EK E + S+A ME EN D +Q D E
Sbjct: 481 KVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGT 540
Query: 537 --HQKCHAEHT----PEEEIDHTGAKTKSAVSDKQDRLNQ--TLKKGKVK--SIDLPIQS 586
+ A+ T P E+ K A + +++Q KK K+K +++LPI++
Sbjct: 541 QPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEA 600
Query: 587 SLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPE 646
+L QLG+DLLN YIE EGKMIMQDKLEKERNDAKNAVEEYVY+FRD+L YEKFI +
Sbjct: 601 NLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQ 660
Query: 647 DLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLG 706
D +L +TE+WLYE+GEDQ KQ YVDKL+EL K G P+++++ E EERPK +LG
Sbjct: 661 DHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELG 720
Query: 707 KKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVV 766
+++Q K+ +RNKDE+Y+H+D +EM+KVEK +++ M W+N+ MNAQ K SL QDPVV
Sbjct: 721 QRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVV 780
Query: 767 KVSEIVAKSKELDNFCNPIIYKPKPKAEVPEDKPKANSEHNGP 809
+ EI K KEL+N C P++ +PKPK E PK NGP
Sbjct: 781 RAQEIKTKIKELNNTCEPVVTQPKPKIE----SPKLERTPNGP 819
>gi|195976805 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 304 bits (779), Expect = 2e-82
Identities = 238/911 (26%), Positives = 422/911 (46%), Gaps = 100/911 (10%)
Query: 1 MSVVGIDLGFLNCYIAVARSG-GIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTN 59
++V+ +DLG + +A+ + G +E + N+ S R TP ++L R G++A S + N
Sbjct: 33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKN 92
Query: 60 VRNTIHGFKKLHGRSFDDPIVQTERIRLP-YELQKMPNGSAGVKVRY-LEEERPFAIEQV 117
+ T+ F+ L G+ D+P V + R P +EL P V + + + F+ E+V
Sbjct: 93 PKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQT---VHFQISSQLQFSPEEV 149
Query: 118 TGMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAV 177
GM+L + +E+ ++P+ D VI++P FF AERR+V+ AA++AGL L+L+N+ TA
Sbjct: 150 LGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTAT 209
Query: 178 ALAYGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGK---------LKVLATTFD 228
AL+YG++++ ++ +N++F DMG + + + K L++ FD
Sbjct: 210 ALSYGVFRR--KDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFD 267
Query: 229 PYLGGRNFD----EALVDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDL 284
LGG + E L F ++ K + +V+EN RA+ +L +E +LK ++SANA D
Sbjct: 268 RTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANA-DH 326
Query: 285 PLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGA 344
IE M+D+D +K+ R +FE+LCA L RV P++ ++ A + ++I + +VGGA
Sbjct: 327 MAQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGA 386
Query: 345 TRIPAVKEQITKFFLK-DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSIT 403
TR+P V+E + K K ++ +NADEA A G Q A LS AFKV+ F + D V Y I
Sbjct: 387 TRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPIL 446
Query: 404 LRWKTSFEDGSG-------ECEVFCKNHPAPFSKVITFHK-KEPFELEAFYTNLHEVPYP 455
+ + E+ G + +F + P P KVITF++ F Y +L +
Sbjct: 447 VEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPE 506
Query: 456 DARI-GSFTIQNVFPQSDGDSSK---------VKVKVRVNIHGIFSVASASVIEKQNLEG 505
D R+ GS + V + GDS K +K ++ G+ S+ + + +E
Sbjct: 507 DLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVED 566
Query: 506 ------------------------------------DHSDAPMETETSFKNENKDNMDKM 529
+ ++P E E + ++
Sbjct: 567 SAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEA 626
Query: 530 QVDQEEGHQ----KCHAEHTPE------------------EEIDHTGAKTKSAVSDKQDR 567
+ E+G Q + + TPE E G + + + + +
Sbjct: 627 EAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKK 686
Query: 568 LNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEY 627
K+ V+ I + + L +D L ++ + ++D ++ER A N++E +
Sbjct: 687 QKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAF 746
Query: 628 VYDFRDRL-GTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQ 686
+++ +D+L Y++ T E ++S L WL ++G + +KL EL+K Q
Sbjct: 747 IFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQ 806
Query: 687 PIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMS 746
+ + E ++ P+ L+ L + ++ R E EM +EK I++ +
Sbjct: 807 GLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWA 866
Query: 747 WLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDNFCNPIIYKPKPKAEVPEDKPKANSEH 806
W N+ + Q KL T+ PV+ +I AK LD ++ K K P K K +
Sbjct: 867 WKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRA 926
Query: 807 NGPMDGQSGTE 817
P++ + +
Sbjct: 927 EPPLNASASDQ 937
>gi|5453832 hypoxia up-regulated 1 precursor [Homo sapiens]
Length = 999
Score = 304 bits (779), Expect = 2e-82
Identities = 238/911 (26%), Positives = 422/911 (46%), Gaps = 100/911 (10%)
Query: 1 MSVVGIDLGFLNCYIAVARSG-GIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTN 59
++V+ +DLG + +A+ + G +E + N+ S R TP ++L R G++A S + N
Sbjct: 33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKN 92
Query: 60 VRNTIHGFKKLHGRSFDDPIVQTERIRLP-YELQKMPNGSAGVKVRY-LEEERPFAIEQV 117
+ T+ F+ L G+ D+P V + R P +EL P V + + + F+ E+V
Sbjct: 93 PKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQT---VHFQISSQLQFSPEEV 149
Query: 118 TGMLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAV 177
GM+L + +E+ ++P+ D VI++P FF AERR+V+ AA++AGL L+L+N+ TA
Sbjct: 150 LGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTAT 209
Query: 178 ALAYGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGK---------LKVLATTFD 228
AL+YG++++ ++ +N++F DMG + + + K L++ FD
Sbjct: 210 ALSYGVFRR--KDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFD 267
Query: 229 PYLGGRNFD----EALVDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDL 284
LGG + E L F ++ K + +V+EN RA+ +L +E +LK ++SANA D
Sbjct: 268 RTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANA-DH 326
Query: 285 PLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGA 344
IE M+D+D +K+ R +FE+LCA L RV P++ ++ A + ++I + +VGGA
Sbjct: 327 MAQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGA 386
Query: 345 TRIPAVKEQITKFFLK-DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSIT 403
TR+P V+E + K K ++ +NADEA A G Q A LS AFKV+ F + D V Y I
Sbjct: 387 TRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPIL 446
Query: 404 LRWKTSFEDGSG-------ECEVFCKNHPAPFSKVITFHK-KEPFELEAFYTNLHEVPYP 455
+ + E+ G + +F + P P KVITF++ F Y +L +
Sbjct: 447 VEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPE 506
Query: 456 DARI-GSFTIQNVFPQSDGDSSK---------VKVKVRVNIHGIFSVASASVIEKQNLEG 505
D R+ GS + V + GDS K +K ++ G+ S+ + + +E
Sbjct: 507 DLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVED 566
Query: 506 ------------------------------------DHSDAPMETETSFKNENKDNMDKM 529
+ ++P E E + ++
Sbjct: 567 SAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEA 626
Query: 530 QVDQEEGHQ----KCHAEHTPE------------------EEIDHTGAKTKSAVSDKQDR 567
+ E+G Q + + TPE E G + + + + +
Sbjct: 627 EAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKK 686
Query: 568 LNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEY 627
K+ V+ I + + L +D L ++ + ++D ++ER A N++E +
Sbjct: 687 QKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAF 746
Query: 628 VYDFRDRL-GTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQ 686
+++ +D+L Y++ T E ++S L WL ++G + +KL EL+K Q
Sbjct: 747 IFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQ 806
Query: 687 PIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMS 746
+ + E ++ P+ L+ L + ++ R E EM +EK I++ +
Sbjct: 807 GLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWA 866
Query: 747 WLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDNFCNPIIYKPKPKAEVPEDKPKANSEH 806
W N+ + Q KL T+ PV+ +I AK LD ++ K K P K K +
Sbjct: 867 WKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRA 926
Query: 807 NGPMDGQSGTE 817
P++ + +
Sbjct: 927 EPPLNASASDQ 937
>gi|124256496 heat shock 70kDa protein 1-like [Homo sapiens]
Length = 641
Score = 278 bits (712), Expect = 1e-74
Identities = 182/604 (30%), Positives = 310/604 (51%), Gaps = 48/604 (7%)
Query: 4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNT 63
+GIDLG + V + G +E IAN+ +R TP+ ++ R IG+AAK+Q+ N +NT
Sbjct: 9 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNT 68
Query: 64 IHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLA 123
+ K+L GR F+DP+VQ + P+++ G V V Y E + F E+++ M+L
Sbjct: 69 VFDAKRLIGRKFNDPVVQADMKLWPFQVIN-EGGKPKVLVSYKGENKAFYPEEISSMVLT 127
Query: 124 KLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGI 183
KLKET+E L PV + VI++P++F D++R++ A +AGLN LR++NE TA A+AYG+
Sbjct: 128 KLKETAEAFLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGL 187
Query: 184 YKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDY 243
K + R+V+ D+G + V + + G +V AT D +LGG +FD LV +
Sbjct: 188 DKG-----GQGERHVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSH 242
Query: 244 FCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNR 303
F +EFK K+K ++ +N RA+ RL CE+ K+ +S +++ L I+ +D + + R
Sbjct: 243 FVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLS-SSTQANLEIDSLYEGIDFYTSITR 301
Query: 304 AQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDI 362
A+FE+LCA L P++ + A + + I I +VGG+TRIP V+ + +F +D+
Sbjct: 302 ARFEELCADLFRGTLEPVEKALRDAKMDKAKIHDIVLVGGSTRIPKVQRLLQDYFNGRDL 361
Query: 363 STTLNADEAVARGCALQCAIL--SPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
+ ++N DEAVA G A+Q AIL + KV++ + D+ P S+ L E G
Sbjct: 362 NKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLLDVAPLSLGL------ETAGGVMTAL 415
Query: 421 CKNH---PAPFSKVI-TFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSS 476
K + P +++ T+ +P L Y + + +G F + + P G
Sbjct: 416 IKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFDLTGIPPAPRG-VP 474
Query: 477 KVKVKVRVNIHGIFSVA----SASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVD 532
+++V ++ +GI +V S + K + D +K+ +++M +D
Sbjct: 475 QIEVTFDIDANGILNVTATDKSTGKVNKITITNDKG-----------RLSKEEIERMVLD 523
Query: 533 QEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLK----KGKVKSIDLPIQSSL 588
E ++ E+E+ K+A+ + + KGK+ D
Sbjct: 524 AE--------KYKAEDEVQREKIAAKNALESYAFNMKSVVSDEGLKGKISESDKNKILDK 575
Query: 589 CRQL 592
C +L
Sbjct: 576 CNEL 579
Score = 32.3 bits (72), Expect = 1.9
Identities = 28/118 (23%), Positives = 56/118 (47%), Gaps = 5/118 (4%)
Query: 575 GKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDR 634
GKV I + +L ++ + + + K +D++++E+ AKNA+E Y ++ +
Sbjct: 498 GKVNKITITNDKG---RLSKEEIERMVLDAEKYKAEDEVQREKIAAKNALESYAFNMKSV 554
Query: 635 LGTVYEK-FITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMK 691
+ K I+ D +K+ + +WL E + K + K +EL++ PI K
Sbjct: 555 VSDEGLKGKISESDKNKILDKCNELLSWL-EVNQLAEKDEFDHKRKELEQMCNPIITK 611
>gi|167466173 heat shock 70kDa protein 1B [Homo sapiens]
Length = 641
Score = 275 bits (703), Expect = 1e-73
Identities = 178/603 (29%), Positives = 313/603 (51%), Gaps = 42/603 (6%)
Query: 2 SVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVR 61
+ +GIDLG + V + G +E IAN+ +R TP+ ++ R IG+AAK+Q+ N +
Sbjct: 5 AAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQ 64
Query: 62 NTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGML 121
NT+ K+L GR F DP+VQ++ P+++ V+V Y E + F E+++ M+
Sbjct: 65 NTVFDAKRLIGRKFGDPVVQSDMKHWPFQVIN-DGDKPKVQVSYKGETKAFYPEEISSMV 123
Query: 122 LAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAY 181
L K+KE +E L PV + VI++P++F D++R++ A +AGLN LR++NE TA A+AY
Sbjct: 124 LTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAY 183
Query: 182 GIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALV 241
G L + RNV+ D+G + V + + G +V AT D +LGG +FD LV
Sbjct: 184 G-----LDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLV 238
Query: 242 DYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKM 301
++F +EFK K+K ++ +N RA+ RL CE+ K+ +S +++ L I+ +D + +
Sbjct: 239 NHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLS-SSTQASLEIDSLFEGIDFYTSI 297
Query: 302 NRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-K 360
RA+FE+LC+ L P++ + A L + I + +VGG+TRIP V++ + FF +
Sbjct: 298 TRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGR 357
Query: 361 DISTTLNADEAVARGCALQCAIL--SPAFKVREFSITDLVPYSITLRWKTSFEDGSGECE 418
D++ ++N DEAVA G A+Q AIL + V++ + D+ P S+ L E G
Sbjct: 358 DLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGL------ETAGGVMT 411
Query: 419 VFCKNH---PAPFSKVI-TFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGD 474
K + P +++ T+ +P L Y + + +G F + + P G
Sbjct: 412 ALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRG- 470
Query: 475 SSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNE-NKDNMDKMQVDQ 533
+++V ++ +GI +V + + A T T+ K +K+ +++M +
Sbjct: 471 VPQIEVTFDIDANGILNVTAT--------DKSTGKANKITITNDKGRLSKEEIERMVQEA 522
Query: 534 EEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLK----KGKVKSIDLPIQSSLC 589
E ++ E+E+ K+A+ + ++ KGK+ D C
Sbjct: 523 E--------KYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKC 574
Query: 590 RQL 592
+++
Sbjct: 575 QEV 577
Score = 33.1 bits (74), Expect = 1.1
Identities = 23/99 (23%), Positives = 49/99 (49%), Gaps = 2/99 (2%)
Query: 591 QLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEK-FITPEDLS 649
+L ++ + ++ K +D++++ER AKNA+E Y ++ + + K I+ D
Sbjct: 509 RLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK 568
Query: 650 KLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPI 688
K+ ++ +WL + K + K +EL++ PI
Sbjct: 569 KVLDKCQEVISWL-DANTLAEKDEFEHKRKELEQVCNPI 606
>gi|194248072 heat shock 70kDa protein 1A [Homo sapiens]
Length = 641
Score = 275 bits (703), Expect = 1e-73
Identities = 178/603 (29%), Positives = 313/603 (51%), Gaps = 42/603 (6%)
Query: 2 SVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVR 61
+ +GIDLG + V + G +E IAN+ +R TP+ ++ R IG+AAK+Q+ N +
Sbjct: 5 AAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQ 64
Query: 62 NTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGML 121
NT+ K+L GR F DP+VQ++ P+++ V+V Y E + F E+++ M+
Sbjct: 65 NTVFDAKRLIGRKFGDPVVQSDMKHWPFQVIN-DGDKPKVQVSYKGETKAFYPEEISSMV 123
Query: 122 LAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAY 181
L K+KE +E L PV + VI++P++F D++R++ A +AGLN LR++NE TA A+AY
Sbjct: 124 LTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAY 183
Query: 182 GIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALV 241
G L + RNV+ D+G + V + + G +V AT D +LGG +FD LV
Sbjct: 184 G-----LDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLV 238
Query: 242 DYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKM 301
++F +EFK K+K ++ +N RA+ RL CE+ K+ +S +++ L I+ +D + +
Sbjct: 239 NHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLS-SSTQASLEIDSLFEGIDFYTSI 297
Query: 302 NRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-K 360
RA+FE+LC+ L P++ + A L + I + +VGG+TRIP V++ + FF +
Sbjct: 298 TRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGR 357
Query: 361 DISTTLNADEAVARGCALQCAIL--SPAFKVREFSITDLVPYSITLRWKTSFEDGSGECE 418
D++ ++N DEAVA G A+Q AIL + V++ + D+ P S+ L E G
Sbjct: 358 DLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGL------ETAGGVMT 411
Query: 419 VFCKNH---PAPFSKVI-TFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGD 474
K + P +++ T+ +P L Y + + +G F + + P G
Sbjct: 412 ALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRG- 470
Query: 475 SSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNE-NKDNMDKMQVDQ 533
+++V ++ +GI +V + + A T T+ K +K+ +++M +
Sbjct: 471 VPQIEVTFDIDANGILNVTAT--------DKSTGKANKITITNDKGRLSKEEIERMVQEA 522
Query: 534 EEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLK----KGKVKSIDLPIQSSLC 589
E ++ E+E+ K+A+ + ++ KGK+ D C
Sbjct: 523 E--------KYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKC 574
Query: 590 RQL 592
+++
Sbjct: 575 QEV 577
Score = 33.1 bits (74), Expect = 1.1
Identities = 23/99 (23%), Positives = 49/99 (49%), Gaps = 2/99 (2%)
Query: 591 QLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEK-FITPEDLS 649
+L ++ + ++ K +D++++ER AKNA+E Y ++ + + K I+ D
Sbjct: 509 RLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKK 568
Query: 650 KLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPI 688
K+ ++ +WL + K + K +EL++ PI
Sbjct: 569 KVLDKCQEVISWL-DANTLAEKDEFEHKRKELEQVCNPI 606
>gi|34419635 heat shock 70kDa protein 6 (HSP70B') [Homo sapiens]
Length = 643
Score = 269 bits (687), Expect = 9e-72
Identities = 174/572 (30%), Positives = 297/572 (51%), Gaps = 28/572 (4%)
Query: 4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNT 63
VGIDLG + V + G +E +AN+ +R TP+ ++ R +G+AAKSQ N NT
Sbjct: 9 VGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNT 68
Query: 64 IHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLA 123
+ K+L GR F D VQ++ P+ + G V+V Y E++ F E+++ M+L+
Sbjct: 69 VFDAKRLIGRKFADTTVQSDMKHWPFRVVS-EGGKPKVRVCYRGEDKTFYPEEISSMVLS 127
Query: 124 KLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGI 183
K+KET+E L +PV VI++P++F D++R++ A +AGLN LR++NE TA A+AYG+
Sbjct: 128 KMKETAEAYLGQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGL 187
Query: 184 YKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDY 243
++ RNV+ D+G + V V + + G +V AT D +LGG +FD LV++
Sbjct: 188 DRR-----GAGERNVLIFDLGGGTFDVSVLSIDAGVFEVKATAGDTHLGGEDFDNRLVNH 242
Query: 244 FCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNR 303
F +EF+ K+ ++ N RAL RL CE+ K+ +S +++ L I+ +D + + R
Sbjct: 243 FMEEFRRKHGKDLSGNKRALRRLRTACERAKRTLS-SSTQATLEIDSLFEGVDFYTSITR 301
Query: 304 AQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDI 362
A+FE+LC+ L P++ + A L + I + +VGG+TRIP V++ + FF K++
Sbjct: 302 ARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDVVLVGGSTRIPKVQKLLQDFFNGKEL 361
Query: 363 STTLNADEAVARGCALQCAIL--SPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
+ ++N DEAVA G A+Q A+L KV++ + D+ P S+ L G +
Sbjct: 362 NKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLLDVAPLSLGLE-----TAGGVMTTLI 416
Query: 421 CKNHPAPFSKVITF---HKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSK 477
+N P + TF +P Y + + +G F + + P G +
Sbjct: 417 QRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRFELSGIPPAPRG-VPQ 475
Query: 478 VKVKVRVNIHGIFSVA----SASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQ 533
++V ++ +GI SV S K + D E +E ++ + +
Sbjct: 476 IEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHE----AEQYKAED 531
Query: 534 EEGHQKCHAEHTPEEEIDHT-GAKTKSAVSDK 564
E + A+++ E + H G+ + ++ DK
Sbjct: 532 EAQRDRVAAKNSLEAHVFHVKGSLQEESLRDK 563
Score = 30.0 bits (66), Expect = 9.3
Identities = 22/81 (27%), Positives = 44/81 (54%), Gaps = 4/81 (4%)
Query: 610 QDKLEKERNDAKNAVEEYVYDFRDRL--GTVYEKFITPEDLSKLSAVLEDTENWLYEDGE 667
+D+ +++R AKN++E +V+ + L ++ +K I ED K+ + WL E +
Sbjct: 530 EDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDK-IPEEDRRKMQDKCREVLAWL-EHNQ 587
Query: 668 DQPKQVYVDKLQELKKYGQPI 688
K+ Y + +EL++ +PI
Sbjct: 588 LAEKEEYEHQKRELEQICRPI 608
>gi|5729877 heat shock 70kDa protein 8 isoform 1 [Homo sapiens]
Length = 646
Score = 268 bits (686), Expect = 1e-71
Identities = 172/564 (30%), Positives = 293/564 (51%), Gaps = 32/564 (5%)
Query: 4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNT 63
VGIDLG + V + G +E IAN+ +R TP+ ++ R IG+AAK+Q+ N NT
Sbjct: 7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNT 66
Query: 64 IHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLA 123
+ K+L GR FDD +VQ++ P+ + G V+V Y E + F E+V+ M+L
Sbjct: 67 VFDAKRLIGRRFDDAVVQSDMKHWPFMVVN-DAGRPKVQVEYKGETKSFYPEEVSSMVLT 125
Query: 124 KLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGI 183
K+KE +E L K V + V+++P++F D++R++ A +AGLN LR++NE TA A+AYG+
Sbjct: 126 KMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGL 185
Query: 184 YKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDY 243
K+ RNV+ D+G + V + G +V +T D +LGG +FD +V++
Sbjct: 186 DKK-----VGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH 240
Query: 244 FCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNR 303
F EFK K+K ++ EN RA+ RL CE+ K+ +S +++ + I+ +D + + R
Sbjct: 241 FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLS-SSTQASIEIDSLYEGIDFYTSITR 299
Query: 304 AQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDI 362
A+FE+L A L P++ + A L + I I +VGG+TRIP +++ + FF K++
Sbjct: 300 ARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKEL 359
Query: 363 STTLNADEAVARGCALQCAILS--PAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
+ ++N DEAVA G A+Q AILS + V++ + D+ P S+ E G V
Sbjct: 360 NKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSL------GIETAGGVMTVL 413
Query: 421 CKNHPAPFSK----VITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSS 476
K + +K T+ +P L Y + + +G F + + P G
Sbjct: 414 IKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRG-VP 472
Query: 477 KVKVKVRVNIHGIFSVASAS-----------VIEKQNLEGDHSDAPMETETSFKNENKDN 525
+++V ++ +GI +V++ +K L + + ++ +K E++
Sbjct: 473 QIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQ 532
Query: 526 MDKMQVDQEEGHQKCHAEHTPEEE 549
DK+ + + T E+E
Sbjct: 533 RDKVSSKNSLESYAFNMKATVEDE 556
Score = 35.8 bits (81), Expect = 0.17
Identities = 31/147 (21%), Positives = 65/147 (44%), Gaps = 20/147 (13%)
Query: 549 EIDHTGAKTKSAV---SDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEG 605
+ID G SAV + K++++ T KG++ D+ ++
Sbjct: 479 DIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDI---------------ERMVQEAE 523
Query: 606 KMIMQDKLEKERNDAKNAVEEYVYDFRDRL-GTVYEKFITPEDLSKLSAVLEDTENWLYE 664
K +D+ ++++ +KN++E Y ++ + + + I ED K+ + NWL +
Sbjct: 524 KYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWL-D 582
Query: 665 DGEDQPKQVYVDKLQELKKYGQPIQMK 691
+ K+ + + +EL+K PI K
Sbjct: 583 KNQTAEKEEFEHQQKELEKVCNPIITK 609
>gi|24234686 heat shock 70kDa protein 8 isoform 2 [Homo sapiens]
Length = 493
Score = 261 bits (666), Expect = 2e-69
Identities = 154/435 (35%), Positives = 246/435 (56%), Gaps = 17/435 (3%)
Query: 4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNT 63
VGIDLG + V + G +E IAN+ +R TP+ ++ R IG+AAK+Q+ N NT
Sbjct: 7 VGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNT 66
Query: 64 IHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLA 123
+ K+L GR FDD +VQ++ P+ + G V+V Y E + F E+V+ M+L
Sbjct: 67 VFDAKRLIGRRFDDAVVQSDMKHWPFMVVN-DAGRPKVQVEYKGETKSFYPEEVSSMVLT 125
Query: 124 KLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGI 183
K+KE +E L K V + V+++P++F D++R++ A +AGLN LR++NE TA A+AYG+
Sbjct: 126 KMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGL 185
Query: 184 YKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDY 243
K+ RNV+ D+G + V + G +V +T D +LGG +FD +V++
Sbjct: 186 DKK-----VGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH 240
Query: 244 FCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNR 303
F EFK K+K ++ EN RA+ RL CE+ K+ +S +++ + I+ +D + + R
Sbjct: 241 FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLS-SSTQASIEIDSLYEGIDFYTSITR 299
Query: 304 AQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDI 362
A+FE+L A L P++ + A L + I I +VGG+TRIP +++ + FF K++
Sbjct: 300 ARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKEL 359
Query: 363 STTLNADEAVARGCALQCAILS--PAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
+ ++N DEAVA G A+Q AILS + V++ + D+ P S+ E G V
Sbjct: 360 NKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSL------GIETAGGVMTVL 413
Query: 421 CK-NHPAPFSKVITF 434
K N P + TF
Sbjct: 414 IKRNTTIPTKQTQTF 428
>gi|13676857 heat shock 70kDa protein 2 [Homo sapiens]
Length = 639
Score = 258 bits (659), Expect = 2e-68
Identities = 166/563 (29%), Positives = 288/563 (51%), Gaps = 28/563 (4%)
Query: 4 VGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNT 63
+GIDLG + V + G +E IAN+ +R TP+ ++ R IG+AAK+Q+ N NT
Sbjct: 8 IGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNT 67
Query: 64 IHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGMLLA 123
I K+L GR F+D VQ++ P+ + G V+V Y E + F E+++ M+L
Sbjct: 68 IFDAKRLIGRKFEDATVQSDMKHWPFRVVS-EGGKPKVQVEYKGETKTFFPEEISSMVLT 126
Query: 124 KLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGI 183
K+KE +E L V VI++P++F D++R++ A + GLN LR++NE TA A+AYG+
Sbjct: 127 KMKEIAEAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGL 186
Query: 184 YKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEALVDY 243
K+ + +NV+ D+G + V + G +V +T D +LGG +FD +V +
Sbjct: 187 DKKGCAGGE---KNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSH 243
Query: 244 FCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNR 303
+EFK K+K ++ N RA+ RL CE+ K+ +S +++ + I+ +D + + R
Sbjct: 244 LAEEFKRKHKKDIGPNKRAVRRLRTACERAKRTLS-SSTQASIEIDSLYEGVDFYTSITR 302
Query: 304 AQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL-KDI 362
A+FE+L A L P++ + A L + I I +VGG+TRIP +++ + FF K++
Sbjct: 303 ARFEELNADLFRGTLEPVEKALRDAKLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKEL 362
Query: 363 STTLNADEAVARGCALQCAIL--SPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF 420
+ ++N DEAVA G A+Q AIL + V++ + D+ P S+ + G +
Sbjct: 363 NKSINPDEAVAYGAAVQAAILIGDKSENVQDLLLLDVTPLSLGIE-----TAGGVMTPLI 417
Query: 421 CKNHPAPFSKVITF---HKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSK 477
+N P + TF + L Y + + +G F + + P G +
Sbjct: 418 KRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLLGKFDLTGIPPAPRG-VPQ 476
Query: 478 VKVKVRVNIHGIFSVASAS-----------VIEKQNLEGDHSDAPMETETSFKNENKDNM 526
++V ++ +GI +V +A +K L D D ++ +K+E++ N
Sbjct: 477 IEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQEAERYKSEDEANR 536
Query: 527 DKMQVDQEEGHQKCHAEHTPEEE 549
D++ + + T E+E
Sbjct: 537 DRVAAKNALESYTYNIKQTVEDE 559
Score = 39.7 bits (91), Expect = 0.012
Identities = 27/104 (25%), Positives = 53/104 (50%), Gaps = 6/104 (5%)
Query: 591 QLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKF---ITPED 647
+L +D ++ ++ + +D+ ++R AKNA+E Y Y+ + + EK I+ +D
Sbjct: 512 RLSKDDIDRMVQEAERYKSEDEANRDRVAAKNALESYTYNIKQTVED--EKLRGKISEQD 569
Query: 648 LSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMK 691
+K+ ++ NWL + + K Y K +EL++ PI K
Sbjct: 570 KNKILDKCQEVINWL-DRNQMAEKDEYEHKQKELERVCNPIISK 612
>gi|16507237 heat shock 70kDa protein 5 [Homo sapiens]
Length = 654
Score = 252 bits (643), Expect = 1e-66
Identities = 173/596 (29%), Positives = 314/596 (52%), Gaps = 33/596 (5%)
Query: 2 SVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSR-TRAIGNAAKSQIVTNV 60
+VVGIDLG + V ++G +E IAN+ +R TP+ ++ R IG+AAK+Q+ +N
Sbjct: 29 TVVGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNP 88
Query: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYEL-QKMPNGSAGVKVRYLEEERPFAIEQVTG 119
NT+ K+L GR+++DP VQ + LP+++ +K V + + + FA E+++
Sbjct: 89 ENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGG-GQTKTFAPEEISA 147
Query: 120 MLLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVAL 179
M+L K+KET+E L K V V+++P++F DA+R++ A +AGLN +R++NE TA A+
Sbjct: 148 MVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAI 207
Query: 180 AYGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEA 239
AYG+ K+ E +N++ D+G + V + + G +V+AT D +LGG +FD+
Sbjct: 208 AYGLDKR------EGEKNILVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQR 261
Query: 240 LVDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSS 299
++++F +K K +V++++RA+ +L +E EK K+ +S+ + IE F D S
Sbjct: 262 VMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALSSQ-HQARIEIESFYEGEDFSE 320
Query: 300 KMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFL 359
+ RA+FE+L L P++ V+E ++L++ DI I +VGG+TRIP +++ + +FF
Sbjct: 321 TLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIVLVGGSTRIPKIQQLVKEFFN 380
Query: 360 -KDISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECE 418
K+ S +N DEAVA G A+Q +LS + + D+ P +TL +T G +
Sbjct: 381 GKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVCP--LTLGIETV---GGVMTK 435
Query: 419 VFCKNHPAPFSK---VITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDS 475
+ +N P K T +P Y + + +G+F + + P G
Sbjct: 436 LIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGTFDLTGIPPAPRG-V 494
Query: 476 SKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQE- 534
+++V ++++GI V + +G + + + +++M D E
Sbjct: 495 PQIEVTFEIDVNGILRVTAED-------KGTGNKNKITITNDQNRLTPEEIERMVNDAEK 547
Query: 535 --EGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQ---DRLNQTLKKGKVKSIDLPIQ 585
E +K E++ K+ + DK+ +L+ K+ K+++ I+
Sbjct: 548 FAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIE 603
Score = 43.9 bits (102), Expect = 6e-04
Identities = 34/125 (27%), Positives = 59/125 (47%), Gaps = 6/125 (4%)
Query: 591 QLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKF---ITPED 647
+L + + + + K +DK KER D +N +E Y Y ++++G EK ++ ED
Sbjct: 532 RLTPEEIERMVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGD-KEKLGGKLSSED 590
Query: 648 LSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMK-YMEHEERPKALNDLG 706
+ +E+ WL E +D + + K +EL++ QPI K Y P D
Sbjct: 591 KETMEKAVEEKIEWL-ESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTA 649
Query: 707 KKIQL 711
+K +L
Sbjct: 650 EKDEL 654
Score = 35.0 bits (79), Expect = 0.29
Identities = 33/146 (22%), Positives = 58/146 (39%), Gaps = 45/146 (30%)
Query: 643 ITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKAL 702
+TPE++ ++ + D E + ED + + + +D EL+ Y ++
Sbjct: 533 LTPEEIERM---VNDAEKFAEEDKKLKER---IDTRNELESYAYSLK------------- 573
Query: 703 NDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQ 762
N +G K +L K L + E +EK + + + WL S +A
Sbjct: 574 NQIGDKEKLGGK--------------LSSEDKETMEKAVEEKIEWLESHQDAD------- 612
Query: 763 DPVVKVSEIVAKSKELDNFCNPIIYK 788
+ + AK KEL+ PII K
Sbjct: 613 -----IEDFKAKKKELEEIVQPIISK 633
>gi|24234688 heat shock 70kDa protein 9 precursor [Homo sapiens]
Length = 679
Score = 226 bits (577), Expect = 5e-59
Identities = 161/588 (27%), Positives = 287/588 (48%), Gaps = 39/588 (6%)
Query: 2 SVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISL-GSRTRAIGNAAKSQIVTNV 60
+VVGIDLG N +AV + + N R TP+ ++ R +G AK Q VTN
Sbjct: 54 AVVGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNP 113
Query: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM 120
NT + K+L GR +DDP VQ + +P+++ + NG A V+ + ++ Q+
Sbjct: 114 NNTFYATKRLIGRRYDDPEVQKDIKNVPFKIVRASNGDAWVEAH----GKLYSPSQIGAF 169
Query: 121 LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA 180
+L K+KET+EN L + VI++P++F D++R++ A Q++GLN LR++NE TA ALA
Sbjct: 170 VLMKMKETAENYLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALA 229
Query: 181 YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL 240
YG+ K + + + D+G + + + KG +V +T D +LGG +FD+AL
Sbjct: 230 YGLDKSE-------DKVIAVYDLGGGTFDISILEIQKGVFEVKSTNGDTFLGGEDFDQAL 282
Query: 241 VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANAS---DLPLNIECFMNDLDV 297
+ + EFK + +++ +++ AL R+ + EK K +S++ +LP +
Sbjct: 283 LRHIVKEFKRETGVDLTKDNMALQRVREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHL 342
Query: 298 SSKMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKF 357
+ K+ RAQFE + L+ R P + M+ A + + DI + +VGG TR+P V++ +
Sbjct: 343 NMKLTRAQFEGIVTDLIRRTIAPCQKAMQDAEVSKSDIGEVILVGGMTRMPKVQQTVQDL 402
Query: 358 FLKDISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGEC 417
F + S +N DEAVA G A+Q +L A V + + D+ P S+ + G
Sbjct: 403 FGRAPSKAVNPDEAVAIGAAIQGGVL--AGDVTDVLLLDVTPLSLGIETL-----GGVFT 455
Query: 418 EVFCKNHPAPFSKVITFHKKEPFELEA---FYTNLHEVPYPDARIGSFTIQNVFPQSDGD 474
++ +N P K F + + E+ + +G FT+ + P G
Sbjct: 456 KLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDNKLLGQFTLIGIPPAPRG- 514
Query: 475 SSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNM----DKMQ 530
+++V ++ +GI V++ K G +++ ++ +NM +K
Sbjct: 515 VPQIEVTFDIDANGIVHVSA-----KDKGTGREQQIVIQSSGGLSKDDIENMVKNAEKYA 569
Query: 531 VDQEEGHQKCHAEHTPEEEIDHTGAKTK----SAVSDKQDRLNQTLKK 574
+ ++ A + E I T K + +D+ ++L + + K
Sbjct: 570 EEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPADECNKLKEEISK 617
Score = 31.2 bits (69), Expect = 4.2
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 13/102 (12%)
Query: 574 KGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYD--- 630
KG + + IQSS L +D + + ++N K +D+ +KER +A N E ++D
Sbjct: 537 KGTGREQQIVIQSS--GGLSKDDIENMVKNAEKYAEEDRRKKERVEAVNMAEGIIHDTET 594
Query: 631 ----FRDRLGTVYEKFITPEDLSKLSAVLEDTENWLYEDGED 668
F+D+L E E++SK+ +L ++ E GE+
Sbjct: 595 KMEEFKDQL-PADECNKLKEEISKMRELLARKDS---ETGEN 632
>gi|82880658 heat shock 70kDa protein 14 isoform 1 [Homo sapiens]
Length = 509
Score = 189 bits (479), Expect = 1e-47
Identities = 118/388 (30%), Positives = 202/388 (52%), Gaps = 15/388 (3%)
Query: 1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV 60
M+ +G+ LG + +AV + G +AN+ DR TPA ++ +G AAK + N+
Sbjct: 1 MAAIGVHLGCTSACVAVYKDGRAGVVANDAGDRVTPAVVAYSENEEIVGLAAKQSRIRNI 60
Query: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM 120
NT+ K++ GRS DP Q + I L NG ++ EE + E V +
Sbjct: 61 SNTVMKVKQILGRSSSDPQAQ-KYIAESKCLVIEKNGKLRYEIDTGEETKFVNPEDVARL 119
Query: 121 LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA 180
+ +K+KET+ + L D VI++P F + ++ ++ AA+ AG N LRL++E +A LA
Sbjct: 120 IFSKMKETAHSVLGSDANDVVITVPFDFGEKQKNALGEAARAAGFNVLRLIHEPSAALLA 179
Query: 181 YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL 240
YGI QD P N++ +G ++ + V N G +VL+T D +GG +F E L
Sbjct: 180 YGI-GQDSP---TGKSNILVFKLGGTSLSLSVMEVNSGIYRVLSTNTDDNIGGAHFTETL 235
Query: 241 VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDL----D 296
Y EF+ +K +V+ N+RA+++L E K +S S CF++ L D
Sbjct: 236 AQYLASEFQRSFKHDVRGNARAMMKLTNSAEVAKHSLSTLGS-----ANCFLDSLYEGQD 290
Query: 297 VSSKMNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITK 356
++RA+FE LC+ L + ++ +++Q +DI+ + + GG++RIP +++ I
Sbjct: 291 FDCNVSRARFELLCSPLFNKCIEAIRGLLDQNGFTADDINKVVLCGGSSRIPKLQQLIKD 350
Query: 357 FF-LKDISTTLNADEAVARGCALQCAIL 383
F ++ ++ DE + G A++ IL
Sbjct: 351 LFPAVELLNSIPPDEVIPIGAAIEAGIL 378
>gi|48928056 heat shock protein 70kDa family member 13 precursor
[Homo sapiens]
Length = 471
Score = 149 bits (376), Expect = 1e-35
Identities = 119/424 (28%), Positives = 201/424 (47%), Gaps = 54/424 (12%)
Query: 3 VVGIDLGFLNCYIAV--ARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV 60
V+GIDLG C + V +G ++ I +E P+ +S +G + +N
Sbjct: 33 VIGIDLGTTYCSVGVFFPGTGKVKVIPDENGHISIPSMVSFTDNDVYVGYESVELADSNP 92
Query: 61 RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM 120
+NTI+ K+ G+ F ++ E R P+++ NG V E + E V
Sbjct: 93 QNTIYDAKRFIGKIFTAEELEAEIGRYPFKVLNK-NGMVEFSVTS-NETITVSPEYVGSR 150
Query: 121 LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA 180
LL KLKE +E L PVA+ VIS+P+ F +R S + AA +AGL LR++NE TA A+A
Sbjct: 151 LLLKLKEMAEAYLGMPVANAVISVPAEFDLKQRNSTIEAANLAGLKILRVINEPTAAAMA 210
Query: 181 YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL 240
YG++K D+ +V+ ID+G V + G A + + LGG++F++ L
Sbjct: 211 YGLHKADV-------FHVLVIDLGGGTLDVSLLNKQGGMFLTRAMSGNNKLGGQDFNQRL 263
Query: 241 VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANAS------------------ 282
+ Y + Y V + RL Q E +K ++ + S
Sbjct: 264 LQYLYKQIYQTYGF-VPSRKEEIHRLRQAVEMVKLNLTLHQSAQLSVLLTVEEQDRKEPH 322
Query: 283 ----DLPLNIECFMNDLDVSS--------------------KMNRAQFEQLCASLLARVE 318
+LP + +D V+S +++R F+ L L ++
Sbjct: 323 SSDTELPKDKLSSADDHRVNSGFGRGLSDKKSGESQVLFETEISRKLFDTLNEDLFQKIL 382
Query: 319 PPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLKDISTTLNADEAVARGCAL 378
P++ V+++ +L++ +I + +VGG+TRIP +++ I +FF KD +T+++ D AV G A+
Sbjct: 383 VPIQQVLKEGHLEKTEIDEVVLVGGSTRIPRIRQVIQEFFGKDPNTSVDPDLAVVTGVAI 442
Query: 379 QCAI 382
Q I
Sbjct: 443 QAGI 446
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/312 (22%), Positives = 129/312 (41%), Gaps = 30/312 (9%)
Query: 479 KVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQ 538
+ K + +H A AS K + +H +E E + + + Q+ G
Sbjct: 626 RAKKELEVHTEALAAEASKDRKLREQSEHYSKQLENEL-------EGLKQKQISYSPG-- 676
Query: 539 KCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLN 598
C EH E T + KS +++ + + ++K++ + S +QL LN
Sbjct: 677 VCSIEHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLA---LN 733
Query: 599 SYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDT 658
I MI++DKLEK R ++++ EE+ +F+ + EK + E+ KL++ L D
Sbjct: 734 KEI-----MILKDKLEKTRRESQSEREEFESEFKQQYER--EKVLLTEENKKLTSEL-DK 785
Query: 659 ENWLYEDGEDQPKQV------YVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLV 712
LYE+ +Q+ DK + + + I + A L +
Sbjct: 786 LTTLYENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKM 845
Query: 713 MKVIEAYRNKDERYDHLD-PTEMEKVEKCISDAMSWLNSKMNAQ--NKLSLTQD-PVVKV 768
+ +EA RN D P +M + K A L S ++A+ K ++ ++ VK
Sbjct: 846 TEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKA 905
Query: 769 SEIVAKSKELDN 780
S I+ + K D+
Sbjct: 906 SNIITECKLKDS 917
Score = 31.2 bits (69), Expect = 4.2
Identities = 41/176 (23%), Positives = 79/176 (44%), Gaps = 15/176 (8%)
Query: 558 KSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKER 617
K +S K QT++ + ++D P+ +S + L L IE K + + +++
Sbjct: 455 KLELSRKLQESTQTVQALQYSTVDGPLTAS--KDLEIKNLKEEIEKLRKQVTESSHLEQQ 512
Query: 618 NDAKNAVEEYVYDFRDRLGTVYEKFITP-----EDLSK-LSAVLEDTENWLYE--DGEDQ 669
+ NAV + + D ++ YEK I EDL+K L E +N E D Q
Sbjct: 513 LEEANAVRQELDDAFRQI-KAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQ 571
Query: 670 PKQVYVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDER 725
K +QE + + + + + ++ + + D +++ LVM+ +E+ R + R
Sbjct: 572 RKLA----MQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRR 623
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 47.8 bits (112), Expect = 4e-05
Identities = 70/308 (22%), Positives = 128/308 (41%), Gaps = 30/308 (9%)
Query: 483 RVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKCHA 542
++ +H A AS K + +H +E E + + + Q+ G C
Sbjct: 549 KLEVHTEALAAEASKDRKLREQSEHYSKQLENEL-------EGLKQKQISYSPG--VCSI 599
Query: 543 EHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDLPIQSSLCRQLGQDLLNSYIE 602
EH E T + KS +++ + + ++K++ + S +QL LN I
Sbjct: 600 EHQQEITKLKTDLEKKSIFYEEELSKREGIHANEIKNLKKELHDSEGQQLA---LNKEI- 655
Query: 603 NEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTENWL 662
MI++DKLEK R ++++ EE+ +F+ + EK + E+ KL++ L D L
Sbjct: 656 ----MILKDKLEKTRRESQSEREEFESEFKQQYER--EKVLLTEENKKLTSEL-DKLTTL 708
Query: 663 YEDGEDQPKQV------YVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVI 716
YE+ +Q+ DK + + + I + A L + + +
Sbjct: 709 YENLSIHNQQLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEEL 768
Query: 717 EAYRNKDERYDHLD-PTEMEKVEKCISDAMSWLNSKMNAQ--NKLSLTQD-PVVKVSEIV 772
EA RN D P +M + K A L S ++A+ K ++ ++ VK S I+
Sbjct: 769 EALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNII 828
Query: 773 AKSKELDN 780
+ K D+
Sbjct: 829 TECKLKDS 836
>gi|5454102 transforming, acidic coiled-coil containing protein 3
[Homo sapiens]
Length = 838
Score = 38.9 bits (89), Expect = 0.020
Identities = 42/201 (20%), Positives = 85/201 (42%), Gaps = 27/201 (13%)
Query: 614 EKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQV 673
+K+ + A +E + R R ++ K + +L +++ E +Y+ E+ KQ
Sbjct: 641 QKDLDAVVKATQEENRELRSRCEELHGKNL------ELGKIMDRFEEVVYQAMEEVQKQK 694
Query: 674 YVDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTE 733
+ K + K + Q+ + K+ +DL K+ + +VIE YR +
Sbjct: 695 ELSKAEIQKVLKEKDQLT-TDLNSMEKSFSDLFKRFEKQKEVIEGYRKNE---------- 743
Query: 734 MEKVEKCISDAMSWLNS--------KMNAQNKLSLTQDPVVKV-SEIVAKSKELDNFCNP 784
E ++KC+ D ++ + K +A+ KL L + + +V S+ A++ L
Sbjct: 744 -ESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRK 802
Query: 785 IIYKPKPKAEVPEDKPKANSE 805
+ + + E K K N E
Sbjct: 803 EQMRIQSLEKTVEQKTKENEE 823
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 38.9 bits (89), Expect = 0.020
Identities = 64/310 (20%), Positives = 129/310 (41%), Gaps = 53/310 (17%)
Query: 498 IEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKT 557
+EK+ ++ + E + +E + K + +E HQ+ + EE+ +T K
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 558 KSAVSDKQDRLNQTLKKGKVKSIDL-----PIQSSLCRQLGQDLLNSYIENEGKMIMQDK 612
K + + D L +L++ K +DL ++ L +L Q+ + IENE K + +K
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL--KLAQESIMD-IENE-KQQLDEK 1085
Query: 613 LEKERNDAKN-------------AVEEYVYDFRDRLGTVYEKF--------ITPEDLSKL 651
L+K+ + N +++ + + + R+ + E+ + S L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 652 SAVLEDTENWLYEDGEDQPKQVYVDKLQ--ELKKYGQPIQMKYMEHEERPKALN------ 703
S LE+ L E G Q+ ++K + E +K + ++ ++HE L
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 704 --DLGKKIQLVMKVIEAY-RNKDERYDHLDPT------------EMEKVEKCISDAMSWL 748
+LG++I + +V + + K E +D +EK+ + + D +S L
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 749 NSKMNAQNKL 758
SK Q +L
Sbjct: 1266 KSKEEEQQRL 1275
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 38.9 bits (89), Expect = 0.020
Identities = 64/310 (20%), Positives = 129/310 (41%), Gaps = 53/310 (17%)
Query: 498 IEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKT 557
+EK+ ++ + E + +E + K + +E HQ+ + EE+ +T K
Sbjct: 970 VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKA 1029
Query: 558 KSAVSDKQDRLNQTLKKGKVKSIDL-----PIQSSLCRQLGQDLLNSYIENEGKMIMQDK 612
K + + D L +L++ K +DL ++ L +L Q+ + IENE K + +K
Sbjct: 1030 KIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL--KLAQESIMD-IENE-KQQLDEK 1085
Query: 613 LEKERNDAKN-------------AVEEYVYDFRDRLGTVYEKF--------ITPEDLSKL 651
L+K+ + N +++ + + + R+ + E+ + S L
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDL 1145
Query: 652 SAVLEDTENWLYEDGEDQPKQVYVDKLQ--ELKKYGQPIQMKYMEHEERPKALN------ 703
S LE+ L E G Q+ ++K + E +K + ++ ++HE L
Sbjct: 1146 SRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADS 1205
Query: 704 --DLGKKIQLVMKVIEAY-RNKDERYDHLDPT------------EMEKVEKCISDAMSWL 748
+LG++I + +V + + K E +D +EK+ + + D +S L
Sbjct: 1206 VAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSEL 1265
Query: 749 NSKMNAQNKL 758
SK Q +L
Sbjct: 1266 KSKEEEQQRL 1275
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 38.1 bits (87), Expect = 0.034
Identities = 33/165 (20%), Positives = 69/165 (41%), Gaps = 10/165 (6%)
Query: 422 KNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTI---QNVFPQSDGDSSKV 478
K A + K HK++ +E+F E PY + + +T Q + + D D ++
Sbjct: 9050 KEKEAVYEKKQAVHKEKRVFIESF-----EEPYDELEVEPYTEPFEQPYYEEPDEDYEEI 9104
Query: 479 KVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQ 538
KV+ + +H + E E + + E E +++ + K EE H+
Sbjct: 9105 KVEAKKEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVY--EESHE 9162
Query: 539 KCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDLP 583
+ PE++ K V +K ++ ++ +++ KV+ +P
Sbjct: 9163 RKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVP 9207
>gi|113204617 skeletal muscle ryanodine receptor isoform 2 [Homo
sapiens]
Length = 5033
Score = 37.7 bits (86), Expect = 0.045
Identities = 43/237 (18%), Positives = 104/237 (43%), Gaps = 24/237 (10%)
Query: 512 METETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQT 571
+E E + E +++ ++ +++E ++ E T +E+ D + ++A +K++ L +
Sbjct: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
Query: 572 LKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDF 631
L + K+ ++ +C LL + + E +Q ++E A+ V++ +
Sbjct: 1926 LLQMKLPE---SVKLQMCH-----LLEYFCDQE----LQHRVESLAAFAERYVDKLQANQ 1973
Query: 632 RDRLGTVYEKFI-----TPEDLSKLSAVLEDTENWL--YEDGEDQ-----PKQVYVDKLQ 679
R R G + + F T + + ++ N L ++DG D+ P+++ D L
Sbjct: 1974 RSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLD 2033
Query: 680 ELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEK 736
+ ++ EE P+ LG ++ +++ + + K+E+ + E K
Sbjct: 2034 FHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
>gi|113204615 skeletal muscle ryanodine receptor isoform 1 [Homo
sapiens]
Length = 5038
Score = 37.7 bits (86), Expect = 0.045
Identities = 43/237 (18%), Positives = 104/237 (43%), Gaps = 24/237 (10%)
Query: 512 METETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQT 571
+E E + E +++ ++ +++E ++ E T +E+ D + ++A +K++ L +
Sbjct: 1866 IEPEVFTEEEEEEDEEEEGEEEDEEEKEEDEEETAQEKEDEEKEEEEAAEGEKEEGLEEG 1925
Query: 572 LKKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDF 631
L + K+ ++ +C LL + + E +Q ++E A+ V++ +
Sbjct: 1926 LLQMKLPE---SVKLQMCH-----LLEYFCDQE----LQHRVESLAAFAERYVDKLQANQ 1973
Query: 632 RDRLGTVYEKFI-----TPEDLSKLSAVLEDTENWL--YEDGEDQ-----PKQVYVDKLQ 679
R R G + + F T + + ++ N L ++DG D+ P+++ D L
Sbjct: 1974 RSRYGLLIKAFSMTAAETARRTREFRSPPQEQINMLLQFKDGTDEEDCPLPEEIRQDLLD 2033
Query: 680 ELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEK 736
+ ++ EE P+ LG ++ +++ + + K+E+ + E K
Sbjct: 2034 FHQDLLAHCGIQLDGEEEEPEEETTLGSRLMSLLEKVRLVKKKEEKPEEERSAEESK 2090
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 37.4 bits (85), Expect = 0.058
Identities = 57/307 (18%), Positives = 131/307 (42%), Gaps = 35/307 (11%)
Query: 464 IQNVFPQSDGDSSKVKVKVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKN-EN 522
+ + QSD SSK+ FS + + + Q L + + + T K E+
Sbjct: 1285 VTGLLSQSDSKSSKLTKD--------FSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336
Query: 523 KDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTLKKGKVKSIDL 582
+ N + Q+++EE A+H E++I A + V+D + ++ ++ L
Sbjct: 1337 EKNSFREQLEEEE-----EAKHNLEKQI----ATLHAQVADMKKKMEDSVGC-------L 1380
Query: 583 PIQSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKF 642
+ R+L +DL +E K+ DKLEK + + +++ + D + +
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLE 1440
Query: 643 ITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYMEHEERPKAL 702
+ +L A E T + Y + D+ + +K + + ++ E E+ L
Sbjct: 1441 KKQKKFDQLLAE-EKTISAKYAEERDRAEAEAREKETKALSLARALE----EAMEQKAEL 1495
Query: 703 NDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKM-NAQNKLSLT 761
L K+ + M+ + + ++ + H E+EK ++ + + + +++ +++L T
Sbjct: 1496 ERLNKQFRTEMEDLMSSKDDVGKSVH----ELEKSKRALEQQVEEMKTQLEELEDELQAT 1551
Query: 762 QDPVVKV 768
+D +++
Sbjct: 1552 EDAKLRL 1558
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 37.0 bits (84), Expect = 0.076
Identities = 68/323 (21%), Positives = 133/323 (41%), Gaps = 49/323 (15%)
Query: 513 ETETSFKNENKDNMDKMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKSAVSDKQDRLNQTL 572
E T N +D +Q+ +EE +EE+ + A+T++ +D Q R +
Sbjct: 1187 EEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQ-RKEEDY 1245
Query: 573 KKGKVKSIDLPIQSSLCRQLGQDLLNSYIENEGKM--IMQDKLEKERNDAKNAV---EEY 627
K K D Q +Q+ +++ S + +E K+ I ++LEK++N + +
Sbjct: 1246 ADLKEKLTDAKKQ---IKQVQKEV--SVMRDEDKLLRIKINELEKKKNQCSQELDMKQRT 1300
Query: 628 VYDFRDRLGT--------VYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVYVDKLQ 679
+ +++L YE+ +DL+ ++ED L E + Q +Q D++
Sbjct: 1301 IQQLKEQLNNQKVEEAIQQYER--ACKDLNVKEKIIEDMRMTLEEQEQTQVEQ---DQVL 1355
Query: 680 ELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEK 739
E K + ++ E E+ + NDL E N+ +H + T++
Sbjct: 1356 EAKL--EEVERLATELEKWKEKCNDL-----------ETKNNQRSNKEHENNTDVLGKLT 1402
Query: 740 CISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDNFCNPIIYKPKPKAEVPEDK 799
+ D + K NA K L + + ++ ++KE +N N K + ED+
Sbjct: 1403 NLQDELQESEQKYNADRKKWLEEKMM-----LITQAKEAENIRN------KEMKKYAEDR 1451
Query: 800 PKANSEHNGPMDGQSGTETKSDS 822
+ + N M+ + T+ DS
Sbjct: 1452 ERFFKQQN-EMEILTAQLTEKDS 1473
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 36.6 bits (83), Expect = 0.100
Identities = 32/164 (19%), Positives = 81/164 (49%), Gaps = 8/164 (4%)
Query: 616 ERNDAKNAVEEYVYDFRDRLGT-VYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVY 674
++ A +EE + RD L +Y IT E+L + +A L++ + E + ++
Sbjct: 187 QKKKADRYIEELTKE-RDALSLELYRNTITDEELKEKNAKLQEKLQLV----ESEKSEIQ 241
Query: 675 VDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEM 734
++ ++ELK+ + ++ + + + +A + LGK++Q V ++A ++E ++ L+ +
Sbjct: 242 LN-VKELKRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKLQAQVEENELWNRLNQQQE 299
Query: 735 EKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKEL 778
EK+ + W + K+ ++ + + E + + +E+
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 36.6 bits (83), Expect = 0.100
Identities = 32/164 (19%), Positives = 81/164 (49%), Gaps = 8/164 (4%)
Query: 616 ERNDAKNAVEEYVYDFRDRLGT-VYEKFITPEDLSKLSAVLEDTENWLYEDGEDQPKQVY 674
++ A +EE + RD L +Y IT E+L + +A L++ + E + ++
Sbjct: 187 QKKKADRYIEELTKE-RDALSLELYRNTITDEELKEKNAKLQEKLQLV----ESEKSEIQ 241
Query: 675 VDKLQELKKYGQPIQMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEM 734
++ ++ELK+ + ++ + + + +A + LGK++Q V ++A ++E ++ L+ +
Sbjct: 242 LN-VKELKRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKLQAQVEENELWNRLNQQQE 299
Query: 735 EKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKEL 778
EK+ + W + K+ ++ + + E + + +E+
Sbjct: 300 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEM 343
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 36.6 bits (83), Expect = 0.100
Identities = 61/290 (21%), Positives = 121/290 (41%), Gaps = 43/290 (14%)
Query: 528 KMQVDQEEGHQKCHAEHTPEEEIDHTGAKTKS---AVSDKQDRLNQTLKKGKVKSIDLPI 584
K + +++G K E E E+ K K+ +++ K L Q L KGK + ++
Sbjct: 800 KKVIHEKDGKIKS-VEELLEAELLKVANKEKTVQLSITSKVQEL-QNLLKGKEEQMNT-- 855
Query: 585 QSSLCRQLGQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVY----------DFRDR 634
++ + +DL N+ GK + L++E K V+E F +
Sbjct: 856 MKAVLEEKEKDLANT-----GKWLQD--LQEENESLKAHVQEVAQHNLKEASSASQFEEL 908
Query: 635 LGTVYEKFITPEDLSKLSAVLEDTEN------WLYEDGEDQPKQVYVDKLQELKKYGQPI 688
+ EK +L +L A+L++ E+ L +D +D+ K ++ ++++LK+
Sbjct: 909 EIVLKEK---ENELKRLEAMLKERESDLSSKTQLLQDVQDENK-LFKSQIEQLKQQNYQQ 964
Query: 689 QMKYMEHEERPKALNDLGKKIQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWL 748
+ HEE K +++ K+I + +++ ++ E + EK + + S
Sbjct: 965 ASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1024
Query: 749 NSKMNAQNKLSLTQDPVVKVSEIVAKSKELDNFCNPIIYKPKPKAEVPED 798
+ NK S + V+ E+ AK ++ K PK VP +
Sbjct: 1025 KMLQDKVNKTSKERQQQVEAVELEAKE---------VLKKLFPKVSVPSN 1065
>gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
sapiens]
Length = 436
Score = 36.6 bits (83), Expect = 0.100
Identities = 60/258 (23%), Positives = 106/258 (41%), Gaps = 40/258 (15%)
Query: 546 PEEEIDHTGAKTKSA-VSDKQDRLNQTLKKGKVK--SIDLPIQSSLCRQ---------LG 593
PE+ ++ T KTK S +L Q L G K ++ + IQ L + L
Sbjct: 65 PEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLS 124
Query: 594 QDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSA 653
Q+L+N E +KLEK RN+ L TVYE F+ K
Sbjct: 125 QELVNLRGELVTASTTCEKLEKARNE---------------LQTVYEAFVQQHQAEK--- 166
Query: 654 VLEDTENWLYEDGEDQPKQVYVDKLQELKKYGQPIQMKY----MEHEERPKALN-DLGKK 708
+ EN L E + +++ ++E +KY +Q ++ HE + +K
Sbjct: 167 --TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 224
Query: 709 IQLVMKVIEAYRNKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKV 768
++L+ K EA ++ ++ + E + +E +S+ L ++N + + +K
Sbjct: 225 LELLKKAYEASLSEIKKGHEI---EKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS 281
Query: 769 SEIVAKSKELDNFCNPII 786
E +++E N NP I
Sbjct: 282 EEQKRRAREKANLKNPQI 299
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,322,159
Number of Sequences: 37866
Number of extensions: 1337824
Number of successful extensions: 4135
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 3912
Number of HSP's gapped (non-prelim): 354
length of query: 839
length of database: 18,247,518
effective HSP length: 111
effective length of query: 728
effective length of database: 14,044,392
effective search space: 10224317376
effective search space used: 10224317376
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.