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Search of human proteins with 31455611
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31455611 zeta-chain associated protein kinase 70kDa isoform
1 [Homo sapiens]
(619 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 1279 0.0
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 698 0.0
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 691 0.0
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 643 0.0
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 230 3e-60
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 230 3e-60
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 226 6e-59
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 226 6e-59
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 226 6e-59
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 226 6e-59
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 226 6e-59
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 216 5e-56
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 216 5e-56
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 213 3e-55
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 213 3e-55
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 210 4e-54
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 208 1e-53
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 208 1e-53
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 207 2e-53
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 207 2e-53
gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo sap... 206 4e-53
gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo sap... 206 4e-53
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 206 5e-53
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 206 5e-53
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 205 9e-53
gi|4503787 fyn-related kinase [Homo sapiens] 205 1e-52
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 204 1e-52
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 204 2e-52
gi|32528301 EPH receptor B4 precursor [Homo sapiens] 202 6e-52
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 202 6e-52
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 1279 bits (3309), Expect = 0.0
Identities = 619/619 (100%), Positives = 619/619 (100%)
Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60
MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60
Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120
Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180
Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240
Query: 241 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT 300
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
Sbjct: 241 LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT 300
Query: 301 SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR 360
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
Sbjct: 301 SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR 360
Query: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 420
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
Sbjct: 361 KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG 420
Query: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
Sbjct: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF 480
Query: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
Sbjct: 481 GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY 540
Query: 541 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
Sbjct: 541 KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL 600
Query: 601 ASKVEGPPGSTQKAEAACA 619
ASKVEGPPGSTQKAEAACA
Sbjct: 601 ASKVEGPPGSTQKAEAACA 619
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 698 bits (1802), Expect = 0.0
Identities = 342/608 (56%), Positives = 450/608 (74%), Gaps = 7/608 (1%)
Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60
M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+
Sbjct: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65
Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120
IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++
Sbjct: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125
Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180
++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G
Sbjct: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185
Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240
++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+
Sbjct: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245
Query: 241 LKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHP-STLTHPQRRIDTLNSDGYTPEPA 297
KADGL+ L C + N + P LP +HP S+ R+ T++ + Y PE A
Sbjct: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPYEPELA 305
Query: 298 RITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG 355
+ P+ +PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G
Sbjct: 306 PWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKG 365
Query: 356 VYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVM 414
Y+M+K VA+K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVM
Sbjct: 366 YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVM 425
Query: 415 EMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474
EMA GPL+K+L R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HY
Sbjct: 426 EMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY 484
Query: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534
AKISDFGLSKAL AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA S
Sbjct: 485 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS 544
Query: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594
YGQKPY+ MKG EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R
Sbjct: 545 YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 604
Query: 595 ACYYSLAS 602
YY + +
Sbjct: 605 NYYYDVVN 612
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 691 bits (1782), Expect = 0.0
Identities = 342/631 (54%), Positives = 451/631 (71%), Gaps = 30/631 (4%)
Query: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60
M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+
Sbjct: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65
Query: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120
IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++
Sbjct: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125
Query: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180
++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G
Sbjct: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185
Query: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240
++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+
Sbjct: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245
Query: 241 LKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHPSTLT-------------------- 278
KADGL+ L C + N + P LP +HP+T +
Sbjct: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRK 305
Query: 279 ----HPQRRIDTLNSDGYTPEPARITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFL 332
R+ T++ + Y PE A + P+ +PMDT VYESPY+DPEE++ K+++L
Sbjct: 306 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 365
Query: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMH 391
R L + D ELG GNFG+V++G Y+M+K VA+K+LK + + A +E++ EA +M
Sbjct: 366 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 425
Query: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKY 451
QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L R + N+ EL+HQVSMGMKY
Sbjct: 426 QLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKY 484
Query: 452 LEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511
LEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL AD++YY A++ GKWP+KWYAPECI
Sbjct: 485 LEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECI 544
Query: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571
N+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG EV A +E+G+RM CP CP E+Y L
Sbjct: 545 NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDL 604
Query: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 602
M+ CW Y E+RP F VE R+R YY + +
Sbjct: 605 MNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 643 bits (1659), Expect = 0.0
Identities = 312/312 (100%), Positives = 312/312 (100%)
Query: 308 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 367
MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA
Sbjct: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
Query: 368 IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV 427
IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV
Sbjct: 61 IKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV 120
Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487
GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG
Sbjct: 121 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 180
Query: 488 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 547
ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE
Sbjct: 181 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPE 240
Query: 548 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 607
VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP
Sbjct: 241 VMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGP 300
Query: 608 PGSTQKAEAACA 619
PGSTQKAEAACA
Sbjct: 301 PGSTQKAEAACA 312
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 230 bits (587), Expect = 3e-60
Identities = 150/453 (33%), Positives = 230/453 (50%), Gaps = 74/453 (16%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217
E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I+
Sbjct: 123 EKHSWYHGPVSRNAAEYLLSSGI--NGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277
GK + ++F+TL +LV + ADGLI +TL
Sbjct: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLI---------------------------TTL 213
Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336
+P +P + +P +VY SP D E++ + +K
Sbjct: 214 HYP--------------------APKRNKP-----TVYGVSPNYDKWEMERTDITMKH-- 246
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G +G V +GV++ K + VA+K LK+ T + EE ++EA +M ++ +P
Sbjct: 247 ------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 296
Query: 397 YIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L+GVC E ++ M G L R+E+ + + Q+S M+YLE+
Sbjct: 297 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK 356
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + +
Sbjct: 357 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 414
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
KFS +SDVW++GV +WE +YG PY + +V +E+ RME P CP ++Y LM
Sbjct: 415 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 474
Query: 575 CWIYKWEDRPDFLTVEQRMRACYY--SLASKVE 605
CW + DRP F + Q + S++ +VE
Sbjct: 475 CWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 507
Score = 39.3 bits (90), Expect = 0.011
Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 7/106 (6%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69
+++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G
Sbjct: 127 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 184
Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEP 110
++ AEL +S DGL L P N+P+ G+ P
Sbjct: 185 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP 230
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 230 bits (587), Expect = 3e-60
Identities = 150/453 (33%), Positives = 230/453 (50%), Gaps = 74/453 (16%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217
E+ WYH ++R AE L SG +G FL+R + G ++SL Y VYHY I+
Sbjct: 142 EKHSWYHGPVSRNAAEYLLSSGI--NGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199
Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277
GK + ++F+TL +LV + ADGLI +TL
Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLI---------------------------TTL 232
Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336
+P +P + +P +VY SP D E++ + +K
Sbjct: 233 HYP--------------------APKRNKP-----TVYGVSPNYDKWEMERTDITMKH-- 265
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G +G V +GV++ K + VA+K LK+ T + EE ++EA +M ++ +P
Sbjct: 266 ------KLGGGQYGEVYEGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 315
Query: 397 YIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L+GVC E ++ M G L R+E+ + + Q+S M+YLE+
Sbjct: 316 NLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK 375
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + +
Sbjct: 376 KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 433
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
KFS +SDVW++GV +WE +YG PY + +V +E+ RME P CP ++Y LM
Sbjct: 434 KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA 493
Query: 575 CWIYKWEDRPDFLTVEQRMRACYY--SLASKVE 605
CW + DRP F + Q + S++ +VE
Sbjct: 494 CWQWNPSDRPSFAEIHQAFETMFQESSISDEVE 526
Score = 39.3 bits (90), Expect = 0.011
Identities = 32/106 (30%), Positives = 54/106 (50%), Gaps = 7/106 (6%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69
+++G +SR A E+L +G+ +G FL+R+ S G +SL ++ R +H+ I +G
Sbjct: 146 WYHGPVSR-NAAEYLLSSGI-NGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 203
Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC---NRPS--GLEP 110
++ AEL +S DGL L P N+P+ G+ P
Sbjct: 204 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSP 249
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 226 bits (575), Expect = 6e-59
Identities = 145/444 (32%), Positives = 216/444 (48%), Gaps = 72/444 (16%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217
E+ WYH ++R AE L S +G FL+R + G ++SL Y VYHY I+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277
GK + ++F TL +LV + ADGL
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGL------------------------------- 240
Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336
+T+ P P +VY SP D E++ + +K
Sbjct: 241 ---------------------VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH-- 277
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G +G V GV++ K + VA+K LK+ T + EE ++EA +M ++ +P
Sbjct: 278 ------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 327
Query: 397 YIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L+GVC E ++ M G L REE+ + + Q+S M+YLE+
Sbjct: 328 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 387
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + +
Sbjct: 388 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 445
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
FS +SDVW++GV +WE +YG PY + +V +E+G RME P CPP++Y LM
Sbjct: 446 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 505
Query: 575 CWIYKWEDRPDFLTVEQRMRACYY 598
CW + DRP F Q ++
Sbjct: 506 CWKWSPADRPSFAETHQAFETMFH 529
Score = 46.2 bits (108), Expect = 9e-05
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 7/106 (6%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69
+++G +SR+ AE L+ + +G FL+R+ S G +SL ++ R +H+ I +G
Sbjct: 158 WYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215
Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP---CNRPS--GLEP 110
+ AEL +S DGL L P CN+P+ G+ P
Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 226 bits (575), Expect = 6e-59
Identities = 145/444 (32%), Positives = 216/444 (48%), Gaps = 72/444 (16%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217
E+ WYH ++R AE L S +G FL+R + G ++SL Y VYHY I+
Sbjct: 169 EKHSWYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277
GK + ++F TL +LV + ADGL
Sbjct: 227 DGKVYVTAESRFSTLAELVHHHSTVADGL------------------------------- 255
Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336
+T+ P P +VY SP D E++ + +K
Sbjct: 256 ---------------------VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH-- 292
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G +G V GV++ K + VA+K LK+ T + EE ++EA +M ++ +P
Sbjct: 293 ------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 342
Query: 397 YIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L+GVC E ++ M G L REE+ + + Q+S M+YLE+
Sbjct: 343 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 402
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + +
Sbjct: 403 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 460
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
FS +SDVW++GV +WE +YG PY + +V +E+G RME P CPP++Y LM
Sbjct: 461 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 520
Query: 575 CWIYKWEDRPDFLTVEQRMRACYY 598
CW + DRP F Q ++
Sbjct: 521 CWKWSPADRPSFAETHQAFETMFH 544
Score = 46.2 bits (108), Expect = 9e-05
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 7/106 (6%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69
+++G +SR+ AE L+ + +G FL+R+ S G +SL ++ R +H+ I +G
Sbjct: 173 WYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 230
Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP---CNRPS--GLEP 110
+ AEL +S DGL L P CN+P+ G+ P
Sbjct: 231 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 276
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 226 bits (575), Expect = 6e-59
Identities = 145/444 (32%), Positives = 216/444 (48%), Gaps = 72/444 (16%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217
E+ WYH ++R AE L S +G FL+R + G ++SL Y VYHY I+
Sbjct: 148 EKHSWYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205
Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277
GK + ++F TL +LV + ADGL
Sbjct: 206 DGKVYVTAESRFSTLAELVHHHSTVADGL------------------------------- 234
Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336
+T+ P P +VY SP D E++ + +K
Sbjct: 235 ---------------------VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH-- 271
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G +G V GV++ K + VA+K LK+ T + EE ++EA +M ++ +P
Sbjct: 272 ------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 321
Query: 397 YIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L+GVC E ++ M G L REE+ + + Q+S M+YLE+
Sbjct: 322 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 381
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + +
Sbjct: 382 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 439
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
FS +SDVW++GV +WE +YG PY + +V +E+G RME P CPP++Y LM
Sbjct: 440 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 499
Query: 575 CWIYKWEDRPDFLTVEQRMRACYY 598
CW + DRP F Q ++
Sbjct: 500 CWKWSPADRPSFAETHQAFETMFH 523
Score = 46.2 bits (108), Expect = 9e-05
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 7/106 (6%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69
+++G +SR+ AE L+ + +G FL+R+ S G +SL ++ R +H+ I +G
Sbjct: 152 WYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 209
Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP---CNRPS--GLEP 110
+ AEL +S DGL L P CN+P+ G+ P
Sbjct: 210 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 255
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 226 bits (575), Expect = 6e-59
Identities = 145/444 (32%), Positives = 216/444 (48%), Gaps = 72/444 (16%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217
E+ WYH ++R AE L S +G FL+R + G ++SL Y VYHY I+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277
GK + ++F TL +LV + ADGL
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGL------------------------------- 240
Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336
+T+ P P +VY SP D E++ + +K
Sbjct: 241 ---------------------VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH-- 277
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G +G V GV++ K + VA+K LK+ T + EE ++EA +M ++ +P
Sbjct: 278 ------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 327
Query: 397 YIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L+GVC E ++ M G L REE+ + + Q+S M+YLE+
Sbjct: 328 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 387
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + +
Sbjct: 388 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 445
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
FS +SDVW++GV +WE +YG PY + +V +E+G RME P CPP++Y LM
Sbjct: 446 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 505
Query: 575 CWIYKWEDRPDFLTVEQRMRACYY 598
CW + DRP F Q ++
Sbjct: 506 CWKWSPADRPSFAETHQAFETMFH 529
Score = 46.2 bits (108), Expect = 9e-05
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 7/106 (6%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69
+++G +SR+ AE L+ + +G FL+R+ S G +SL ++ R +H+ I +G
Sbjct: 158 WYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215
Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP---CNRPS--GLEP 110
+ AEL +S DGL L P CN+P+ G+ P
Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 226 bits (575), Expect = 6e-59
Identities = 145/444 (32%), Positives = 216/444 (48%), Gaps = 72/444 (16%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDK 217
E+ WYH ++R AE L S +G FL+R + G ++SL Y VYHY I+
Sbjct: 133 EKHSWYHGPVSRSAAEYLLSS--LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 190
Query: 218 AGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTL 277
GK + ++F TL +LV + ADGL
Sbjct: 191 DGKVYVTAESRFSTLAELVHHHSTVADGL------------------------------- 219
Query: 278 THPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYE-SPYSDPEELKDKKLFLKRDN 336
+T+ P P +VY SP D E++ + +K
Sbjct: 220 ---------------------VTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKH-- 256
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G +G V GV++ K + VA+K LK+ T + EE ++EA +M ++ +P
Sbjct: 257 ------KLGGGQYGEVYVGVWK--KYSLTVAVKTLKEDT--MEVEEFLKEAAVMKEIKHP 306
Query: 397 YIVRLIGVCQAEALMLVME--MAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L+GVC E ++ M G L REE+ + + Q+S M+YLE+
Sbjct: 307 NLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEK 366
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
KNF+HRDLAARN L+ H K++DFGLS+ + D YTA + K+P+KW APE + +
Sbjct: 367 KNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPESLAYN 424
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
FS +SDVW++GV +WE +YG PY + +V +E+G RME P CPP++Y LM
Sbjct: 425 TFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRA 484
Query: 575 CWIYKWEDRPDFLTVEQRMRACYY 598
CW + DRP F Q ++
Sbjct: 485 CWKWSPADRPSFAETHQAFETMFH 508
Score = 46.2 bits (108), Expect = 9e-05
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 7/106 (6%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGTY 69
+++G +SR+ AE L+ + +G FL+R+ S G +SL ++ R +H+ I +G
Sbjct: 137 WYHGPVSRSAAE--YLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 194
Query: 70 AIAGGKAHCGPAELCEFYSRDPDGLPCNLRKP---CNRPS--GLEP 110
+ AEL +S DGL L P CN+P+ G+ P
Sbjct: 195 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 240
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 216 bits (550), Expect = 5e-56
Identities = 108/251 (43%), Positives = 158/251 (62%), Gaps = 3/251 (1%)
Query: 344 LGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402
+G G FG V QG+Y + + VAIK K T + E+ ++EA M Q D+P+IV+LI
Sbjct: 450 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 509
Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462
GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+
Sbjct: 510 GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 569
Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522
AARNVL+ + K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV
Sbjct: 570 AARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 627
Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582
W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y
Sbjct: 628 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 687
Query: 583 RPDFLTVEQRM 593
RP F ++ ++
Sbjct: 688 RPRFTELKAQL 698
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 216 bits (550), Expect = 5e-56
Identities = 108/251 (43%), Positives = 158/251 (62%), Gaps = 3/251 (1%)
Query: 344 LGCGNFGSVRQGVYRMRKKQ-IDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLI 402
+G G FG V QG+Y + + VAIK K T + E+ ++EA M Q D+P+IV+LI
Sbjct: 428 IGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLI 487
Query: 403 GVCQAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDL 462
GV + ++ME+ G L FL ++ + ++++ +Q+S + YLE K FVHRD+
Sbjct: 488 GVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 547
Query: 463 AARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDV 522
AARNVL+ + K+ DFGLS+ + +DS Y S GK P+KW APE INFR+F+S SDV
Sbjct: 548 AARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDV 605
Query: 523 WSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWED 582
W +GV MWE L +G KP++ +K +V+ IE G+R+ PP CPP LY+LM+ CW Y
Sbjct: 606 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSR 665
Query: 583 RPDFLTVEQRM 593
RP F ++ ++
Sbjct: 666 RPRFTELKAQL 676
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 213 bits (543), Expect = 3e-55
Identities = 140/431 (32%), Positives = 211/431 (48%), Gaps = 76/431 (17%)
Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 216
WY +TR E+ER L + G FL+R + +G Y LS+ G V HY I +
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210
Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 276
+G + I T+F++L QLV Y ADGL + L CP S
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS------------------- 251
Query: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDN 336
KP+ + +E P R++
Sbjct: 252 ---------------------------KPQTQGLAKDAWEIP---------------RES 269
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
L + +++LG G FG V G + + VAIK LK GT E ++EAQ+M +L +
Sbjct: 270 LRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGT--MSPEAFLQEAQVMKKLRHE 323
Query: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEK 455
+V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Y+E
Sbjct: 324 KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515
N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE + +
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR 441
Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575
F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ LM C
Sbjct: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501
Query: 576 WIYKWEDRPDF 586
W + E+RP F
Sbjct: 502 WRKEPEERPTF 512
Score = 39.3 bits (90), Expect = 0.011
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 5/98 (5%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64
+++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I +
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210
Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102
+G + I +L +YS+ DGL L C
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 213 bits (543), Expect = 3e-55
Identities = 140/431 (32%), Positives = 211/431 (48%), Gaps = 76/431 (17%)
Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 216
WY +TR E+ER L + G FL+R + +G Y LS+ G V HY I +
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210
Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 276
+G + I T+F++L QLV Y ADGL + L CP S
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS------------------- 251
Query: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDN 336
KP+ + +E P R++
Sbjct: 252 ---------------------------KPQTQGLAKDAWEIP---------------RES 269
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
L + +++LG G FG V G + + VAIK LK GT E ++EAQ+M +L +
Sbjct: 270 LRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGT--MSPEAFLQEAQVMKKLRHE 323
Query: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEK 455
+V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Y+E
Sbjct: 324 KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515
N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE + +
Sbjct: 384 NYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR 441
Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575
F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ LM C
Sbjct: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501
Query: 576 WIYKWEDRPDF 586
W + E+RP F
Sbjct: 502 WRKEPEERPTF 512
Score = 39.3 bits (90), Expect = 0.011
Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 5/98 (5%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64
+++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I +
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210
Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102
+G + I +L +YS+ DGL L C
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 210 bits (534), Expect = 4e-54
Identities = 143/458 (31%), Positives = 220/458 (48%), Gaps = 79/458 (17%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSLI-----YGKTVYHYL 212
E W+ ++R++AER+L + G F++R + +G+Y+LS+ G TV HY
Sbjct: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199
Query: 213 I-SQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLP 271
I + D G Y P T F TL +LV++ K DGL L C +S
Sbjct: 200 IRTLDNGGFYISPRST-FSTLQELVDHYKKGNDGLCQKLSVPCMSSK------------- 245
Query: 272 AHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLF 331
PQ+ P + +E P E LK +K
Sbjct: 246 --------PQK--------------------------PWEKDAWEIPR---ESLKLEK-- 266
Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391
+LG G FG V Y K VA+K +K G+ E + EA +M
Sbjct: 267 -----------KLGAGQFGEVWMATYNKHTK---VAVKTMKPGS--MSVEAFLAEANVMK 310
Query: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKR-EEIPVSNVAELLHQVSMGMK 450
L + +V+L V E + ++ E G L FL + P+ + + Q++ GM
Sbjct: 311 TLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510
++E++N++HRDL A N+L+ KI+DFGL++ + +D+ YTAR K+P+KW APE
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPIKWTAPEA 428
Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570
INF F+ +SDVWS+G+ + E ++YG+ PY M PEV+ +E+G RM P CP ELY
Sbjct: 429 INFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYN 488
Query: 571 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPP 608
+M CW + E+RP F ++ + Y + S+ + P
Sbjct: 489 IMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526
Score = 41.2 bits (95), Expect = 0.003
Identities = 31/98 (31%), Positives = 44/98 (44%), Gaps = 5/98 (5%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-VHDVR----FHHFPIERQ 64
+F+ ISR +AE L G G F++R + G Y LS+ +D R H+ I
Sbjct: 144 WFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTL 203
Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102
NG + I+ EL + Y + DGL L PC
Sbjct: 204 DNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPC 241
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo
sapiens]
Length = 983
Score = 208 bits (529), Expect = 1e-53
Identities = 122/313 (38%), Positives = 177/313 (56%), Gaps = 16/313 (5%)
Query: 310 MDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRM-RKKQIDVAI 368
+D YE P E + L N+ I D +G G FG V G ++ KK+I VAI
Sbjct: 597 VDPHTYEDPTQAVHEFAKE---LDATNISI-DKVVGAGEFGEVCSGRLKLPSKKEISVAI 652
Query: 369 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 427
K LK G + + + EA IM Q D+P I+RL GV +++ +M+V E G L FL
Sbjct: 653 KTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLR 712
Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487
+ V + +L ++ GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 713 KHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLE 772
Query: 488 AD-DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 546
D ++ YT R GK P++W +PE I +RKF+S SDVWSYG+ +WE +SYG++PY +M
Sbjct: 773 DDPEAAYTTRG-GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQ 831
Query: 547 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 606
+V+ +++G R+ P +CP LY LM DCW +RP F + S+ K+
Sbjct: 832 DVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQI--------VSILDKLIR 883
Query: 607 PPGSTQKAEAACA 619
PGS + +A A
Sbjct: 884 NPGSLKIITSAAA 896
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 208 bits (529), Expect = 1e-53
Identities = 118/284 (41%), Positives = 165/284 (58%), Gaps = 10/284 (3%)
Query: 314 VYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAI 368
+Y P Y DP E + F K ++ IE +G G FG V +G ++ K++I VAI
Sbjct: 593 IYIDPFTYEDPNEAVRE--FAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAI 650
Query: 369 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 427
K LK G + + + EA IM Q D+P I+RL GV ++ +M++ E G L FL
Sbjct: 651 KTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLR 710
Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487
+ V + +L ++ GMKYL E N+VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 711 QNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQ 770
Query: 488 AD--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545
D D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +S+G++PY M
Sbjct: 771 DDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSN 830
Query: 546 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589
+V+ IEQ R+ P +CP L+ LM DCW RP F +
Sbjct: 831 QDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEI 874
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 207 bits (527), Expect = 2e-53
Identities = 143/436 (32%), Positives = 214/436 (49%), Gaps = 79/436 (18%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLI-----YGKTVYHYL 212
E PW+ +L+R++AER+L + T G FL+R + G+++LS+ G+ V HY
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
Query: 213 ISQ-DKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLP 271
I D G Y P T F L +LV + +DGL C S
Sbjct: 183 IRNLDNGGFYISPRIT-FPGLHELVRHYTNASDGL-------CTRLS------------- 221
Query: 272 AHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLF 331
P + P KP +E + P
Sbjct: 222 -----------------------RPCQTQKPQKPW--------WEDEWEVP--------- 241
Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391
R+ L + + LG G FG V G Y K VA+K LKQG+ D + EA +M
Sbjct: 242 --RETLKLVE-RLGAGQFGEVWMGYYNGHTK---VAVKSLKQGSMSPDA--FLAEANLMK 293
Query: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMK 450
QL + +VRL V E + ++ E G L FL ++ ++ + ++ Q++ GM
Sbjct: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510
++EE+N++HRDL A N+L+ + KI+DFGL++ + +D+ YTAR K+P+KW APE
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEA 411
Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570
IN+ F+ +SDVWS+G+ + E +++G+ PY M PEV+ +E+G RM P CP ELY
Sbjct: 412 INYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQ 471
Query: 571 LMSDCWIYKWEDRPDF 586
LM CW + EDRP F
Sbjct: 472 LMRLCWKERPEDRPTF 487
Score = 47.0 bits (110), Expect = 5e-05
Identities = 33/108 (30%), Positives = 48/108 (44%), Gaps = 7/108 (6%)
Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR------FHHFPIE 62
P+F+ ++SR +AE L G G FL+R+ + G + LS V D H+ I
Sbjct: 126 PWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLS-VRDFDQNQGEVVKHYKIR 184
Query: 63 RQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEP 110
NG + I+ G EL Y+ DGL L +PC +P
Sbjct: 185 NLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 207 bits (527), Expect = 2e-53
Identities = 143/436 (32%), Positives = 214/436 (49%), Gaps = 79/436 (18%)
Query: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLI-----YGKTVYHYL 212
E PW+ +L+R++AER+L + T G FL+R + G+++LS+ G+ V HY
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYK 182
Query: 213 ISQ-DKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLP 271
I D G Y P T F L +LV + +DGL C S
Sbjct: 183 IRNLDNGGFYISPRIT-FPGLHELVRHYTNASDGL-------CTRLS------------- 221
Query: 272 AHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLF 331
P + P KP +E + P
Sbjct: 222 -----------------------RPCQTQKPQKPW--------WEDEWEVP--------- 241
Query: 332 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 391
R+ L + + LG G FG V G Y K VA+K LKQG+ D + EA +M
Sbjct: 242 --RETLKLVE-RLGAGQFGEVWMGYYNGHTK---VAVKSLKQGSMSPDA--FLAEANLMK 293
Query: 392 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVSMGMK 450
QL + +VRL V E + ++ E G L FL ++ ++ + ++ Q++ GM
Sbjct: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 451 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 510
++EE+N++HRDL A N+L+ + KI+DFGL++ + +D+ YTAR K+P+KW APE
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEA 411
Query: 511 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 570
IN+ F+ +SDVWS+G+ + E +++G+ PY M PEV+ +E+G RM P CP ELY
Sbjct: 412 INYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQ 471
Query: 571 LMSDCWIYKWEDRPDF 586
LM CW + EDRP F
Sbjct: 472 LMRLCWKERPEDRPTF 487
Score = 47.0 bits (110), Expect = 5e-05
Identities = 33/108 (30%), Positives = 48/108 (44%), Gaps = 7/108 (6%)
Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVR------FHHFPIE 62
P+F+ ++SR +AE L G G FL+R+ + G + LS V D H+ I
Sbjct: 126 PWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLS-VRDFDQNQGEVVKHYKIR 184
Query: 63 RQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEP 110
NG + I+ G EL Y+ DGL L +PC +P
Sbjct: 185 NLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
>gi|221625422 ephrin receptor EphA5 isoform b precursor [Homo
sapiens]
Length = 1015
Score = 206 bits (525), Expect = 4e-53
Identities = 115/273 (42%), Positives = 161/273 (58%), Gaps = 8/273 (2%)
Query: 319 YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAIKVLKQGT 375
Y DP + + F K IE +G G FG V G ++ K+++ VAIK LK G
Sbjct: 634 YEDPNQAVHE--FAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY 691
Query: 376 EKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIP 434
+ + + EA IM Q D+P I+ L GV +++ +M+V E G L FL +
Sbjct: 692 TEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT 751
Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD-DSYY 493
V + +L +S GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D ++ Y
Sbjct: 752 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 811
Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553
T R GK P++W APE I FRKF+S SDVWSYG+ MWE +SYG++PY +M +V+ +E
Sbjct: 812 TTRG-GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE 870
Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586
+G R+ P +CP LY LM DCW + RP F
Sbjct: 871 EGYRLPSPMDCPAALYQLMLDCWQKERNSRPKF 903
>gi|221625401 ephrin receptor EphA5 isoform a precursor [Homo
sapiens]
Length = 1037
Score = 206 bits (525), Expect = 4e-53
Identities = 115/273 (42%), Positives = 161/273 (58%), Gaps = 8/273 (2%)
Query: 319 YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAIKVLKQGT 375
Y DP + + F K IE +G G FG V G ++ K+++ VAIK LK G
Sbjct: 656 YEDPNQAVHE--FAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGY 713
Query: 376 EKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIP 434
+ + + EA IM Q D+P I+ L GV +++ +M+V E G L FL +
Sbjct: 714 TEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFT 773
Query: 435 VSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD-DSYY 493
V + +L +S GMKYL + +VHRDLAARN+L+ + K+SDFGLS+ L D ++ Y
Sbjct: 774 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 833
Query: 494 TARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIE 553
T R GK P++W APE I FRKF+S SDVWSYG+ MWE +SYG++PY +M +V+ +E
Sbjct: 834 TTRG-GKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE 892
Query: 554 QGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586
+G R+ P +CP LY LM DCW + RP F
Sbjct: 893 EGYRLPSPMDCPAALYQLMLDCWQKERNSRPKF 925
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 206 bits (524), Expect = 5e-53
Identities = 145/454 (31%), Positives = 221/454 (48%), Gaps = 78/454 (17%)
Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 216
WY L R++AER+L S G FL+R + +G Y+LS+ + G V HY I +
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208
Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 276
G Y I +F+TL QLV++ KADGL + L
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSEKADGLCFNL-------------------------- 242
Query: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDN 336
T+ + TP+ + + D E+ + L L++
Sbjct: 243 ---------TVIASSCTPQTSGLAK-------------------DAWEVARRSLCLEK-- 272
Query: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396
+LG G F V G + K VAIK LK GT E + EAQIM +L +
Sbjct: 273 ------KLGQGCFAEVWLGTWNGNTK---VAIKTLKPGT--MSPESFLEEAQIMKKLKHD 321
Query: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLV-GKREEIPVSNVAELLHQVSMGMKYLEEK 455
+V+L V E + +V E G L FL G+ + + N+ ++ QV+ GM Y+E
Sbjct: 322 KLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 381
Query: 456 NFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515
N++HRDL + N+L+ N KI+DFGL++ + +D+ YTAR K+P+KW APE + +
Sbjct: 382 NYIHRDLRSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR 439
Query: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575
F+ +SDVWS+G+ + E ++ G+ PY M EV+ +E+G RM CP +CP L+ LM C
Sbjct: 440 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 499
Query: 576 WIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPG 609
W E+RP F ++ + Y A++ + PG
Sbjct: 500 WKKDPEERPTFEYLQSFLED--YFTATEPQYQPG 531
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/94 (29%), Positives = 42/94 (44%), Gaps = 5/94 (5%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64
+++G + R +AE L G G FL+R+ + G Y LS+ + H+ I +
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208
Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNL 98
NG Y I +L + YS DGL NL
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSEKADGLCFNL 242
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 206 bits (524), Expect = 5e-53
Identities = 128/345 (37%), Positives = 186/345 (53%), Gaps = 15/345 (4%)
Query: 250 LKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMP 309
++E P S+A+G + + + +R + +S+ YT + TS M
Sbjct: 537 IQEKLPLIIGSSAAGLVFLIAVVVIAIVCNRRRGFERADSE-YTDKLQHYTSGH----MT 591
Query: 310 MDTSVYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQI 364
+Y P Y DP E + F K ++ IE +G G FG V G ++ K++I
Sbjct: 592 PGMKIYIDPFTYEDPNEAVRE--FAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREI 649
Query: 365 DVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLH 423
VAIK LK G + + + EA IM Q D+P ++ L GV ++ +M++ E G L
Sbjct: 650 FVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLD 709
Query: 424 KFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLS 483
FL + V + +L ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS
Sbjct: 710 SFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLS 769
Query: 484 KALGAD--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYK 541
+ L D D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY
Sbjct: 770 RFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYW 829
Query: 542 KMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586
M +V+ IEQ R+ P +CP L+ LM DCW RP F
Sbjct: 830 DMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKF 874
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 205 bits (522), Expect = 9e-53
Identities = 116/281 (41%), Positives = 162/281 (57%), Gaps = 10/281 (3%)
Query: 314 VYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDVAI 368
+Y P Y DP E + F K ++ IE +G G FG V G ++ K++I VAI
Sbjct: 595 IYIDPFTYEDPNEAVRE--FAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAI 652
Query: 369 KVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLV 427
K LK G + + + EA IM Q D+P ++ L GV ++ +M++ E G L FL
Sbjct: 653 KTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR 712
Query: 428 GKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALG 487
+ V + +L ++ GMKYL + N+VHRDLAARN+L+ + K+SDFGLS+ L
Sbjct: 713 QNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLE 772
Query: 488 AD--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545
D D YT+ GK P++W APE I +RKF+S SDVWSYG+ MWE +SYG++PY M
Sbjct: 773 DDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTN 832
Query: 546 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586
+V+ IEQ R+ P +CP L+ LM DCW RP F
Sbjct: 833 QDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKF 873
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 205 bits (521), Expect = 1e-52
Identities = 135/436 (30%), Positives = 216/436 (49%), Gaps = 67/436 (15%)
Query: 162 PWYHSSLTREEAERKLYSGAQTDGKFLLRPRKEQ-GTYALSLIYGKTVYHYLISQDKAGK 220
PW+ ++ R +AE++L G FL+R + Q G ++LS++ G V HY I + G
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174
Query: 221 YCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHP 280
+ + F TL + V + +DGL C+K L P
Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGL--CVK-------------------------LGKP 207
Query: 281 QRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIA 340
+I P P D S Y++ D E+ + L +
Sbjct: 208 CLKIQV--------------------PAPFDLS-YKTV--DQWEIDRNSIQLLK------ 238
Query: 341 DIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVR 400
LG G FG V +G++ VA+K LK G+ D + +REAQIM L +P +++
Sbjct: 239 --RLGSGQFGEVWEGLWN---NTTPVAVKTLKPGS--MDPNDFLREAQIMKNLRHPKLIQ 291
Query: 401 LIGVCQAE-ALMLVMEMAGGGPLHKFLVGKR-EEIPVSNVAELLHQVSMGMKYLEEKNFV 458
L VC E + ++ E+ G L ++L +I ++ ++ QV+ GM YLE +N++
Sbjct: 292 LYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYI 351
Query: 459 HRDLAARNVLLVNRHYAKISDFGLSKALGAD-DSYYTARSAGKWPLKWYAPECINFRKFS 517
HRDLAARNVL+ + K++DFGL++ D + Y +R K P+KW APE I KFS
Sbjct: 352 HRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFS 411
Query: 518 SRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWI 577
+SDVWS+G+ ++E ++YG+ PY M G +V+ + Q R+ P CP + Y +M +CW
Sbjct: 412 IKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWN 471
Query: 578 YKWEDRPDFLTVEQRM 593
+ ++RP F T+ ++
Sbjct: 472 AEPKERPTFETLRWKL 487
Score = 50.8 bits (120), Expect = 4e-06
Identities = 28/94 (29%), Positives = 47/94 (50%)
Query: 9 PFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIERQLNGT 68
P+F+G+I R++AE+ L + G FL+R+ G + LS++ H+ I+R G
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174
Query: 69 YAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102
+ + + E Y++ DGL L KPC
Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPC 208
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 204 bits (520), Expect = 1e-52
Identities = 111/284 (39%), Positives = 158/284 (55%), Gaps = 3/284 (1%)
Query: 309 PMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR--KKQIDV 366
P+ T V Y DP + K + + +G G FG V +G+ + KK++ V
Sbjct: 584 PLKTYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPV 643
Query: 367 AIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKF 425
AIK LK G + + + EA IM Q + I+RL GV + +M++ E G L KF
Sbjct: 644 AIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKF 703
Query: 426 LVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 485
L K E V + +L ++ GMKYL N+VHRDLAARN+L+ + K+SDFGLS+
Sbjct: 704 LREKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRV 763
Query: 486 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKG 545
L D S GK P++W APE I++RKF+S SDVWS+G+ MWE ++YG++PY ++
Sbjct: 764 LEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSN 823
Query: 546 PEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTV 589
EVM I G R+ P +CP +Y LM CW + RP F +
Sbjct: 824 HEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADI 867
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 204 bits (519), Expect = 2e-52
Identities = 148/455 (32%), Positives = 221/455 (48%), Gaps = 77/455 (16%)
Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 216
WY L R++AER+L S G FL+R + +G Y+LS+ + G V HY I +
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208
Query: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 276
G Y I +F+TL QLV++ +A GL L +P H
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSERAAGLCCRL------------------VVPCH--- 247
Query: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVYESPYSDPEELKDKKLF-LKRD 335
K P D SV K K ++ + R+
Sbjct: 248 ---------------------------KGMPRLTDLSV-----------KTKDVWEIPRE 269
Query: 336 NLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN 395
+L + LG G FG V G + K VAIK LK GT E + EAQIM +L +
Sbjct: 270 SLQLIK-RLGNGQFGEVWMGTWNGNTK---VAIKTLKPGT--MSPESFLEEAQIMKKLKH 323
Query: 396 PYIVRLIGVCQAEALMLVMEMAGGGPLHKFLV-GKREEIPVSNVAELLHQVSMGMKYLEE 454
+V+L V E + +V E G L FL G+ + + N+ ++ QV+ GM Y+E
Sbjct: 324 DKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 383
Query: 455 KNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 514
N++HRDL + N+L+ N KI+DFGL++ + +D+ YTAR K+P+KW APE +
Sbjct: 384 MNYIHRDLRSANILVGNGLICKIADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYG 441
Query: 515 KFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSD 574
+F+ +SDVWS+G+ + E ++ G+ PY M EV+ +E+G RM CP +CP L+ LM
Sbjct: 442 RFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIH 501
Query: 575 CWIYKWEDRPDFLTVEQRMRACYYSLASKVEGPPG 609
CW E+RP F ++ + Y A++ + PG
Sbjct: 502 CWKKDPEERPTFEYLQSFLED--YFTATEPQYQPG 534
Score = 44.7 bits (104), Expect = 3e-04
Identities = 29/100 (29%), Positives = 45/100 (45%), Gaps = 5/100 (5%)
Query: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64
+++G + R +AE L G G FL+R+ + G Y LS+ + H+ I +
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208
Query: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNR 104
NG Y I +L + YS GL C L PC++
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHK 248
>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
Length = 987
Score = 202 bits (515), Expect = 6e-52
Identities = 118/283 (41%), Positives = 162/283 (57%), Gaps = 10/283 (3%)
Query: 312 TSVYESP--YSDPEELKDKKLFLKRDNLLIADIE--LGCGNFGSVRQGVYRMR-KKQIDV 366
T VY P Y DP E + F K ++ IE +G G FG V +G + KK+ V
Sbjct: 587 TKVYIDPFTYEDPNEAVRE--FAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCV 644
Query: 367 AIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKF 425
AIK LK G + E + EA IM Q ++P I+RL GV + +M++ E G L F
Sbjct: 645 AIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSF 704
Query: 426 LVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 485
L + V + +L ++ GM+YL E ++VHRDLAARN+L+ + K+SDFGLS+
Sbjct: 705 LRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRF 764
Query: 486 L--GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKM 543
L + D YT+ GK P++W APE I FRKF+S SD WSYG+ MWE +S+G++PY M
Sbjct: 765 LEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDM 824
Query: 544 KGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586
+V+ IEQ R+ PP+CP L+ LM DCW RP F
Sbjct: 825 SNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRF 867
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 202 bits (515), Expect = 6e-52
Identities = 103/269 (38%), Positives = 161/269 (59%), Gaps = 7/269 (2%)
Query: 326 KDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMR 385
KDKK L +++++ ++ LG GNFG V +G K + VA+K K+ + + ++
Sbjct: 552 KDKKWILSHEDVILGEL-LGKGNFGEVYKGTL---KDKTSVAVKTCKEDLPQELKIKFLQ 607
Query: 386 EAQIMHQLDNPYIVRLIGVC-QAEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQ 444
EA+I+ Q D+P IV+LIGVC Q + + ++ME+ GG FL K++E+ + + +
Sbjct: 608 EAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLD 667
Query: 445 VSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLK 504
+ GM YLE KN +HRDLAARN L+ + KISDFG+S+ D Y++ + P+K
Sbjct: 668 AAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQ--EDGGVYSSSGLKQIPIK 725
Query: 505 WYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPEC 564
W APE +N+ ++SS SDVWS+G+ +WE S G PY M + +E+G RM P C
Sbjct: 726 WTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHC 785
Query: 565 PPELYALMSDCWIYKWEDRPDFLTVEQRM 593
P ++ +M CW YK E+RP F +++ +
Sbjct: 786 PEDISKIMMKCWDYKPENRPKFSELQKEL 814
Score = 37.0 bits (84), Expect = 0.054
Identities = 23/59 (38%), Positives = 33/59 (55%), Gaps = 4/59 (6%)
Query: 4 PAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFPIE 62
P A +++G+I R EA+E LK G FL+R+ G YVLS+ D + HF I+
Sbjct: 454 PLAEQDWYHGAIPRIEAQELLK----KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQ 508
Score = 33.1 bits (74), Expect = 0.78
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 9/78 (11%)
Query: 163 WYHSSLTREEAERKLYSGAQTDGKFLLR-PRKEQGTYALSLIYGKTVYHYLISQ-DKAGK 220
WYH ++ R EA+ L + G FL+R + G Y LS+ H++I D +
Sbjct: 460 WYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYR 515
Query: 221 YCIPEGTKFDTLWQLVEY 238
+ EGT F + QL+++
Sbjct: 516 F---EGTGFSNIPQLIDH 530
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,158,466
Number of Sequences: 37866
Number of extensions: 1273613
Number of successful extensions: 5683
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 629
Number of HSP's successfully gapped in prelim test: 242
Number of HSP's that attempted gapping in prelim test: 3755
Number of HSP's gapped (non-prelim): 1227
length of query: 619
length of database: 18,247,518
effective HSP length: 108
effective length of query: 511
effective length of database: 14,157,990
effective search space: 7234732890
effective search space used: 7234732890
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.