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Search of human proteins with 30039692
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|30039692 NIMA-related kinase 8 [Homo sapiens]
(692 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 1391 0.0
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 405 e-113
gi|83627721 NIMA-related kinase 5 [Homo sapiens] 247 2e-65
gi|41872673 NIMA-related kinase 1 [Homo sapiens] 242 1e-63
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 216 6e-56
gi|4505373 NIMA-related kinase 2 [Homo sapiens] 188 1e-47
gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens] 188 1e-47
gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens] 188 1e-47
gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens] 188 1e-47
gi|19424132 NIMA-related kinase 7 [Homo sapiens] 177 3e-44
gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens] 176 6e-44
gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens] 176 6e-44
gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens] 176 6e-44
gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens] 176 6e-44
gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens] 176 6e-44
gi|217330634 serine/threonine kinase 36 [Homo sapiens] 151 2e-36
gi|126032348 hect domain and RLD 2 [Homo sapiens] 150 4e-36
gi|116256471 SNF1-like kinase [Homo sapiens] 142 8e-34
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 142 1e-33
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 142 1e-33
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 142 1e-33
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 142 1e-33
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 142 1e-33
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 139 9e-33
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 139 1e-32
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 139 1e-32
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 139 1e-32
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 139 1e-32
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 139 1e-32
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 139 1e-32
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 1391 bits (3601), Expect = 0.0
Identities = 692/692 (100%), Positives = 692/692 (100%)
Query: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH
Sbjct: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
Query: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH
Sbjct: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
Query: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPY 180
THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPY
Sbjct: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPY 180
Query: 181 NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLS 240
NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLS
Sbjct: 181 NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLS 240
Query: 241 LEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPR 300
LEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPR
Sbjct: 241 LEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPR 300
Query: 301 GPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPP 360
GPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPP
Sbjct: 301 GPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPP 360
Query: 361 LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN 420
LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN
Sbjct: 361 LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN 420
Query: 421 GCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR 480
GCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR
Sbjct: 421 GCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTR 480
Query: 481 ESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVP 540
ESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVP
Sbjct: 481 ESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVP 540
Query: 541 HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG 600
HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG
Sbjct: 541 HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG 600
Query: 601 SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQL 660
SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQL
Sbjct: 601 SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQL 660
Query: 661 DETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP 692
DETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP
Sbjct: 661 DETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP 692
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 405 bits (1042), Expect = e-113
Identities = 259/706 (36%), Positives = 380/706 (53%), Gaps = 54/706 (7%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y IRV+GRGAFG L R D LV+ K++ + +++++ER+ A NE +L LL H N+
Sbjct: 52 YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNI 111
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
I YY +F+++ L+I +EY GG L + I ++ + L EEE ++ + QI+ A+ +H
Sbjct: 112 IAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAG 171
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK-SKAYTVVGTPCYISPELCEGKPYNQ 182
ILHRD+KT NI L K + +K+GD+G++K L+S+ S A T+VGTP Y+SPELC+G YN
Sbjct: 172 ILHRDIKTLNIFLTKANL-IKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF 230
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFA--PISDRYSPELRQLVLSLLS 240
KSDIWA+GCV++EL +LKR F+A N L +KI+ G A S +YS EL Q+V S L
Sbjct: 231 KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQMVHSCLD 290
Query: 241 LEPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPR 300
+P QRP ++ +PL +R RR E + + T R +
Sbjct: 291 QDPEQRPTADELLDRPL--------------LRKRRREMEEKVTLLNAPTKRPRSSTVTE 336
Query: 301 GPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNT--EVVQVAAGRTQKAGVTRSGRLILWEA 358
P+ + S VY WGGG TP +L ++ + QV AG T A VT L W
Sbjct: 337 API-AVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTW-- 393
Query: 359 PPLGAGGGSLLPGAV------EQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGII 412
+ GG+ L G + QP+ + + G I+ V+CGD FT C+TD G +
Sbjct: 394 --VNMQGGTKLHGQLGHGDKASYRQPKHVEKL----QGKAIRQVSCGDDFTVCVTDEGQL 447
Query: 413 MTFGSGSNGCLGHGSLT--DISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRG 470
FGS GC+G + ++ +P + L + QV+CG +HV+ L+ +E+++WG G
Sbjct: 448 YAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCG 507
Query: 471 DSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLD 530
+ GRLGL + E + PQ+V +P V CG D + +LT G+ LACG N FNKLGL+
Sbjct: 508 EYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLN 567
Query: 531 HLSLG-EEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQ 589
G + +V SFTL + L + +I G H+AA+ G TFG N+
Sbjct: 568 QCMSGIINHEAYHEVPYTTSFTL--AKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNK 625
Query: 590 HGQLGTNTRRGSRAPCKVQG--LEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGR 647
GQLG + R + G L G ++ V+CGD FT+A ++ +++WG G GRL
Sbjct: 626 CGQLGVGNYK-KRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
Query: 648 --------RDEDAGLPRPVQLDETHPYTVTSVSCCHGNTLLAVRSV 685
D PRP+ H V +SC +T+L V V
Sbjct: 685 TPTERPHGSDICTSWPRPIFGSLHH---VPDLSCRGWHTILIVEKV 727
>gi|83627721 NIMA-related kinase 5 [Homo sapiens]
Length = 708
Score = 247 bits (631), Expect = 2e-65
Identities = 121/257 (47%), Positives = 172/257 (66%), Gaps = 1/257 (0%)
Query: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
M+KY+ I+ +G+GAFG +L K+D K +IK+I E+M +E++A++ E +L+ + H
Sbjct: 1 MDKYDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKKEVILLEKMKH 60
Query: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
PN++ ++ +F E+ L I MEY GG L + I ++ L E+ IL +FVQI L L H+H
Sbjct: 61 PNIVAFFNSFQENGRLFIVMEYCDGGDLMKRINRQRGVLFSEDQILGWFVQISLGLKHIH 120
Query: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCEGKP 179
ILHRD+K QNI L K+ MV K+GDFGI+++L +S A T +GTP Y+SPE+C+ KP
Sbjct: 121 DRKILHRDIKAQNIFLSKNGMVAKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQNKP 180
Query: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239
YN K+DIW+LGCVLYEL +LK FE NL LVLKI FAPIS +S EL L+ L
Sbjct: 181 YNNKTDIWSLGCVLYELCTLKHPFEGNNLQQLVLKICQAHFAPISPGFSRELHSLISQLF 240
Query: 240 SLEPAQRPPLSHIMAQP 256
+ P RP ++ I+ +P
Sbjct: 241 QVSPRDRPSINSILKRP 257
>gi|41872673 NIMA-related kinase 1 [Homo sapiens]
Length = 1258
Score = 242 bits (617), Expect = 1e-63
Identities = 124/254 (48%), Positives = 173/254 (68%), Gaps = 2/254 (0%)
Query: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
MEKY R++ +G G+FG L D + +IK+I + +M+ +ER+ ++ E VL + H
Sbjct: 1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
Query: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
PN+++Y E+F E+ +L I M+Y GG L + I + L +E+ IL +FVQI LAL HVH
Sbjct: 61 PNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVH 120
Query: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKP 179
ILHRD+K+QNI L K V++GDFGI+++L+S + A T +GTP Y+SPE+CE KP
Sbjct: 121 DRKILHRDIKSQNIFLTKDG-TVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKP 179
Query: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239
YN KSDIWALGCVLYEL +LK AFEA ++ LVLKI+SG+F P+S YS +LR LV L
Sbjct: 180 YNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLF 239
Query: 240 SLEPAQRPPLSHIM 253
P RP ++ I+
Sbjct: 240 KRNPRDRPSVNSIL 253
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 216 bits (550), Expect = 6e-56
Identities = 117/312 (37%), Positives = 188/312 (60%), Gaps = 6/312 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y +RVVG+G++G V L + D K +IK++ + + ER+AA+ E Q+L L HPN+
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 64 IEYYENFLE-DKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTH 122
+ Y E++ D L I M + GG L ++++ LL E ++ +FVQI +AL ++H
Sbjct: 66 VTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQYLHEK 125
Query: 123 LILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK-SKAYTVVGTPCYISPELCEGKPYN 181
ILHRDLKTQN+ L + ++K+GD GI+++L + A T++GTP Y+SPEL KPYN
Sbjct: 126 HILHRDLKTQNVFLTRTN-IIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSNKPYN 184
Query: 182 QKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSL 241
KSD+WALGC +YE+A+LK AF A ++ +LV +I+ G P+ YSPEL +L+ ++LS
Sbjct: 185 YKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRTMLSK 244
Query: 242 EPAQRPPLSHIMAQPLCIRALLNLHTDVGSVRMRRAEKSVAPSNTGSRTTSVRCRGIPRG 301
P +RP + I+ QP R + + + +++ ++ ++ ++ S+ + G
Sbjct: 245 RPEERPSVRSILRQPYIKR---QISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAES 301
Query: 302 PVRPAIPPPLSS 313
P PLSS
Sbjct: 302 NHEVIHPQPLSS 313
>gi|4505373 NIMA-related kinase 2 [Homo sapiens]
Length = 445
Score = 188 bits (478), Expect = 1e-47
Identities = 107/266 (40%), Positives = 154/266 (57%), Gaps = 11/266 (4%)
Query: 2 EKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHP 61
E YE + +G G++G RK+D K+++ K++ MT+ E+Q +E +L+ L HP
Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
Query: 62 NVIEYYENFLE--DKALMIAMEYAPGGTLAEFIQK--RCNSLLEEETILHFFVQILLALH 117
N++ YY+ ++ + L I MEY GG LA I K + L+EE +L Q+ LAL
Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125
Query: 118 HVHT-----HLILHRDLKTQNILLDKHRMVVKIGDFGISKILS-SKSKAYTVVGTPCYIS 171
H H +LHRDLK N+ LD + VK+GDFG+++IL+ S A T VGTP Y+S
Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDG-KQNVKLGDFGLARILNHDTSFAKTFVGTPYYMS 184
Query: 172 PELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPEL 231
PE YN+KSDIW+LGC+LYEL +L F A + L KI G F I RYS EL
Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDEL 244
Query: 232 RQLVLSLLSLEPAQRPPLSHIMAQPL 257
+++ +L+L+ RP + I+ PL
Sbjct: 245 NEIITRMLNLKDYHRPSVEEILENPL 270
>gi|225735561 NIMA-related kinase 3 isoform b [Homo sapiens]
Length = 489
Score = 188 bits (478), Expect = 1e-47
Identities = 96/261 (36%), Positives = 161/261 (61%), Gaps = 3/261 (1%)
Query: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
M+ Y +R++G G+FG L ++ ++ +K+I + + + Q ++ E +L + H
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
Query: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
PN++ + E+F + L I MEY GG L + I+++ L E+ IL++F Q+ L ++H+H
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKP 179
+LHRD+K++NI L ++ V K+GDFG +++LS+ A T VGTP Y+ PE+ E P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239
YN KSDIW+LGC+LYEL +LK F+A + L+LK+ G +P+ YS EL+ LV +
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
Query: 240 SLEPAQRPPLSHIMAQPLCIR 260
P+ RP + ++++ + R
Sbjct: 239 KRNPSHRPSATTLLSRGIVAR 259
>gi|23510391 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 188 bits (478), Expect = 1e-47
Identities = 96/261 (36%), Positives = 161/261 (61%), Gaps = 3/261 (1%)
Query: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
M+ Y +R++G G+FG L ++ ++ +K+I + + + Q ++ E +L + H
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
Query: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
PN++ + E+F + L I MEY GG L + I+++ L E+ IL++F Q+ L ++H+H
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKP 179
+LHRD+K++NI L ++ V K+GDFG +++LS+ A T VGTP Y+ PE+ E P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239
YN KSDIW+LGC+LYEL +LK F+A + L+LK+ G +P+ YS EL+ LV +
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
Query: 240 SLEPAQRPPLSHIMAQPLCIR 260
P+ RP + ++++ + R
Sbjct: 239 KRNPSHRPSATTLLSRGIVAR 259
>gi|23510393 NIMA-related kinase 3 isoform a [Homo sapiens]
Length = 506
Score = 188 bits (478), Expect = 1e-47
Identities = 96/261 (36%), Positives = 161/261 (61%), Gaps = 3/261 (1%)
Query: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
M+ Y +R++G G+FG L ++ ++ +K+I + + + Q ++ E +L + H
Sbjct: 1 MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKH 59
Query: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
PN++ + E+F + L I MEY GG L + I+++ L E+ IL++F Q+ L ++H+H
Sbjct: 60 PNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIH 119
Query: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSK-AYTVVGTPCYISPELCEGKP 179
+LHRD+K++NI L ++ V K+GDFG +++LS+ A T VGTP Y+ PE+ E P
Sbjct: 120 KKRVLHRDIKSKNIFLTQNGKV-KLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLP 178
Query: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLL 239
YN KSDIW+LGC+LYEL +LK F+A + L+LK+ G +P+ YS EL+ LV +
Sbjct: 179 YNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMF 238
Query: 240 SLEPAQRPPLSHIMAQPLCIR 260
P+ RP + ++++ + R
Sbjct: 239 KRNPSHRPSATTLLSRGIVAR 259
>gi|19424132 NIMA-related kinase 7 [Homo sapiens]
Length = 302
Score = 177 bits (449), Expect = 3e-44
Identities = 101/250 (40%), Positives = 153/250 (61%), Gaps = 8/250 (3%)
Query: 10 VGRGAFGIVHLCLRKADQKLVIIKQIPV-EQMTKEERQAAQNECQVLKLLNHPNVIEYYE 68
+GRG F V+ D V +K++ + + M + R E +LK LNHPNVI+YY
Sbjct: 40 IGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYA 99
Query: 69 NFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVHTHLILH 126
+F+ED L I +E A G L+ I+ K+ L+ E T+ +FVQ+ AL H+H+ ++H
Sbjct: 100 SFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMH 159
Query: 127 RDLKTQNILLDKHRMVVKIGDFGISKILSSKSKA-YTVVGTPCYISPELCEGKPYNQKSD 185
RD+K N+ + VVK+GD G+ + SSK+ A +++VGTP Y+SPE YN KSD
Sbjct: 160 RDIKPANVFITATG-VVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSD 218
Query: 186 IWALGCVLYELASLKRAF--EAANLPALVLKIMSGTFAPI-SDRYSPELRQLVLSLLSLE 242
IW+LGC+LYE+A+L+ F + NL +L KI + P+ SD YS ELRQLV ++ +
Sbjct: 219 IWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPD 278
Query: 243 PAQRPPLSHI 252
P +RP ++++
Sbjct: 279 PEKRPDVTYV 288
>gi|41281753 NIMA-related kinase 11 isoform 2 [Homo sapiens]
Length = 470
Score = 176 bits (446), Expect = 6e-44
Identities = 97/269 (36%), Positives = 158/269 (58%), Gaps = 8/269 (2%)
Query: 3 KYERIRVVGRGAFGIVHLCL---RKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLN 59
+Y + +G G+FG V+L K ++L ++K+I V ++ E A E Q+L L+
Sbjct: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
Query: 60 HPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALH 117
HP +++++ +F+E I EY G L + IQ K+ + E I+ +F+Q+LL +
Sbjct: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 118 HVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCE 176
++H ILHRDLK++N+ L + ++KIGDFG+S++L S A T+ GTP Y+SPE +
Sbjct: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Query: 177 GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVL 236
+ Y+ KSDIW+L C+LYE+ + AF +N ++VLKI+ G + +RY EL ++
Sbjct: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
Query: 237 SLLSLEPAQRPPLSHIMAQPLCIRALLNL 265
S+L+ P+ RP I+ P L NL
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
>gi|225637562 NIMA-related kinase 11 isoform 3 [Homo sapiens]
Length = 599
Score = 176 bits (446), Expect = 6e-44
Identities = 97/269 (36%), Positives = 158/269 (58%), Gaps = 8/269 (2%)
Query: 3 KYERIRVVGRGAFGIVHLCL---RKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLN 59
+Y + +G G+FG V+L K ++L ++K+I V ++ E A E Q+L L+
Sbjct: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
Query: 60 HPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALH 117
HP +++++ +F+E I EY G L + IQ K+ + E I+ +F+Q+LL +
Sbjct: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 118 HVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCE 176
++H ILHRDLK++N+ L + ++KIGDFG+S++L S A T+ GTP Y+SPE +
Sbjct: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Query: 177 GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVL 236
+ Y+ KSDIW+L C+LYE+ + AF +N ++VLKI+ G + +RY EL ++
Sbjct: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
Query: 237 SLLSLEPAQRPPLSHIMAQPLCIRALLNL 265
S+L+ P+ RP I+ P L NL
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
>gi|225637560 NIMA-related kinase 11 isoform 1 [Homo sapiens]
Length = 645
Score = 176 bits (446), Expect = 6e-44
Identities = 97/269 (36%), Positives = 158/269 (58%), Gaps = 8/269 (2%)
Query: 3 KYERIRVVGRGAFGIVHLCL---RKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLN 59
+Y + +G G+FG V+L K ++L ++K+I V ++ E A E Q+L L+
Sbjct: 28 RYVLQQKLGSGSFGTVYLVSDKKAKRGEELKVLKEISVGELNPNETVQANLEAQLLSKLD 87
Query: 60 HPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALH 117
HP +++++ +F+E I EY G L + IQ K+ + E I+ +F+Q+LL +
Sbjct: 88 HPAIVKFHASFVEQDNFCIITEYCEGRDLDDKIQEYKQAGKIFPENQIIEWFIQLLLGVD 147
Query: 118 HVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKIL-SSKSKAYTVVGTPCYISPELCE 176
++H ILHRDLK++N+ L + ++KIGDFG+S++L S A T+ GTP Y+SPE +
Sbjct: 148 YMHERRILHRDLKSKNVFLKNN--LLKIGDFGVSRLLMGSCDLATTLTGTPHYMSPEALK 205
Query: 177 GKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVL 236
+ Y+ KSDIW+L C+LYE+ + AF +N ++VLKI+ G + +RY EL ++
Sbjct: 206 HQGYDTKSDIWSLACILYEMCCMNHAFAGSNFLSIVLKIVEGDTPSLPERYPKELNAIME 265
Query: 237 SLLSLEPAQRPPLSHIMAQPLCIRALLNL 265
S+L+ P+ RP I+ P L NL
Sbjct: 266 SMLNKNPSLRPSAIEILKIPYLDEQLQNL 294
>gi|222418622 NIMA-related kinase 6 isoform 1 [Homo sapiens]
Length = 347
Score = 176 bits (446), Expect = 6e-44
Identities = 97/250 (38%), Positives = 154/250 (61%), Gaps = 8/250 (3%)
Query: 10 VGRGAFGIVHLCLRKADQKLVIIKQIPV-EQMTKEERQAAQNECQVLKLLNHPNVIEYYE 68
+GRG F V+ D+K V +K++ + E M + RQ E +LK LNHPN+I+Y +
Sbjct: 85 IGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLD 144
Query: 69 NFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVHTHLILH 126
+F+ED L I +E A G L++ I+ K+ L+ E T+ +FVQ+ A+ H+H+ ++H
Sbjct: 145 SFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMH 204
Query: 127 RDLKTQNILLDKHRMVVKIGDFGISKILSSKSKA-YTVVGTPCYISPELCEGKPYNQKSD 185
RD+K N+ + VVK+GD G+ + SS++ A +++VGTP Y+SPE YN KSD
Sbjct: 205 RDIKPANVFITATG-VVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSD 263
Query: 186 IWALGCVLYELASLKRAF--EAANLPALVLKIMSGTFAPI-SDRYSPELRQLVLSLLSLE 242
IW+LGC+LYE+A+L+ F + NL +L KI + P+ + YS +LR+LV + +
Sbjct: 264 IWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPD 323
Query: 243 PAQRPPLSHI 252
P QRP + ++
Sbjct: 324 PHQRPDIGYV 333
>gi|19923407 NIMA-related kinase 6 isoform 2 [Homo sapiens]
Length = 313
Score = 176 bits (446), Expect = 6e-44
Identities = 97/250 (38%), Positives = 154/250 (61%), Gaps = 8/250 (3%)
Query: 10 VGRGAFGIVHLCLRKADQKLVIIKQIPV-EQMTKEERQAAQNECQVLKLLNHPNVIEYYE 68
+GRG F V+ D+K V +K++ + E M + RQ E +LK LNHPN+I+Y +
Sbjct: 51 IGRGQFSEVYKATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLD 110
Query: 69 NFLEDKALMIAMEYAPGGTLAEFIQ--KRCNSLLEEETILHFFVQILLALHHVHTHLILH 126
+F+ED L I +E A G L++ I+ K+ L+ E T+ +FVQ+ A+ H+H+ ++H
Sbjct: 111 SFIEDNELNIVLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMH 170
Query: 127 RDLKTQNILLDKHRMVVKIGDFGISKILSSKSKA-YTVVGTPCYISPELCEGKPYNQKSD 185
RD+K N+ + VVK+GD G+ + SS++ A +++VGTP Y+SPE YN KSD
Sbjct: 171 RDIKPANVFITATG-VVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSD 229
Query: 186 IWALGCVLYELASLKRAF--EAANLPALVLKIMSGTFAPI-SDRYSPELRQLVLSLLSLE 242
IW+LGC+LYE+A+L+ F + NL +L KI + P+ + YS +LR+LV + +
Sbjct: 230 IWSLGCLLYEMAALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPD 289
Query: 243 PAQRPPLSHI 252
P QRP + ++
Sbjct: 290 PHQRPDIGYV 299
>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
Length = 1315
Score = 151 bits (382), Expect = 2e-36
Identities = 88/259 (33%), Positives = 151/259 (58%), Gaps = 10/259 (3%)
Query: 1 MEKYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNH 60
MEKY + ++G G+FG V+ RK ++V +K IP +++E + Q E ++++ L H
Sbjct: 1 MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRH 60
Query: 61 PNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVH 120
PN++ ++F DK +++ +YA G L + ++ + L E+ + Q++ AL+++H
Sbjct: 61 PNIVHMLDSFETDKEVVVVTDYAE-GELFQILED--DGKLPEDQVQAIAAQLVSALYYLH 117
Query: 121 THLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYT-VVGTPCYISPELCEGKP 179
+H ILHRD+K QNILL K +K+ DFG ++ +S+ + T + GTP Y+SPEL E +P
Sbjct: 118 SHRILHRDMKPQNILLAKGG-GIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERP 176
Query: 180 YNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPI--SDRYSPELRQLVLS 237
Y+ +D+W++GC+LYELA F A ++ LV I+ P+ SP + +
Sbjct: 177 YDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKD---PVRWPSTISPCFKNFLQG 233
Query: 238 LLSLEPAQRPPLSHIMAQP 256
LL+ +P QR ++ P
Sbjct: 234 LLTKDPRQRLSWPDLLYHP 252
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 150 bits (379), Expect = 4e-36
Identities = 107/316 (33%), Positives = 155/316 (49%), Gaps = 30/316 (9%)
Query: 319 GGLGTPLRLPMLNTEVVQ---VAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLP--GAV 373
G + P ++ L++ VV+ V +G +T G++ W G G L +
Sbjct: 3031 GTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSW-----GEGDDGKLGHFSRM 3085
Query: 374 EQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQ 433
+P R +E I+ +ACG +A LT G + T+G G G LGHG T +
Sbjct: 3086 NCDKP----RLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLK 3141
Query: 434 PTIVEALLGYEMVQVACGA--SHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPM 491
P +V+ LLG+ ++QVACG+ + LAL+ E +F+WG GD G+LG G E + PQ +
Sbjct: 3142 PKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER 3201
Query: 492 PPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551
GQ ++ CG S+ LT G G + +LG H S + V QV E L
Sbjct: 3202 LNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLG--HGS--DVHVRKPQVVEGLR-- 3255
Query: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE 611
+ ++ + +G H AVT SG Y +G N HGQ G T +R P VQGLE
Sbjct: 3256 --------GKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE 3307
Query: 612 GIKMAMVACGDAFTVA 627
G K+ VACG + +VA
Sbjct: 3308 GQKITRVACGSSHSVA 3323
Score = 135 bits (340), Expect = 1e-31
Identities = 110/384 (28%), Positives = 169/384 (44%), Gaps = 39/384 (10%)
Query: 313 SVYAWG-------GGL-GTPLRLP-----MLNTEVVQVAAGRTQKAGVTRSGRLILWEAP 359
++Y WG GG+ G +++P + VQ+ G VT G+L A
Sbjct: 3953 TIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLY---AT 4009
Query: 360 PLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACL--TDRGIIMTFGS 417
GAGG + G P LE V IK VA CL + G + ++G
Sbjct: 4010 GYGAGGRLGIGGTESVSTPTL----LESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGE 4065
Query: 418 GSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGL 477
+G LGHG+ + +P ++E+L G E+V VA G +H ++ +L+ WG+G GRLG
Sbjct: 4066 AEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGH 4125
Query: 478 GTRESHSCPQQVPMPPGQEAQRVVCGID--SSMILTVPGQALACGSNRFNKLGLDHLSLG 535
E P+ V G + CG ++ LT + G + KLG
Sbjct: 4126 SDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC 4185
Query: 536 EEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGT 595
+ P+ + S T LG ++ ++ G+ S A+T SG YT+G + +LG
Sbjct: 4186 KVPM------KIDSLTGLG--------VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGH 4231
Query: 596 NTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLP 655
+ R P +VQGL+G K+ +A G V + EVY+WG G+LG +A +
Sbjct: 4232 GSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNA-IQ 4290
Query: 656 RPVQLDETHPYTVTSVSCCHGNTL 679
RP + V V+C +TL
Sbjct: 4291 RPRLVAALQGKKVNRVACGSAHTL 4314
Score = 133 bits (334), Expect = 6e-31
Identities = 100/327 (30%), Positives = 148/327 (45%), Gaps = 36/327 (11%)
Query: 315 YAWGGGLG--------TPLRLPMLN---TEVVQVAAGRTQKAGVTRSGRLILW-EAPPLG 362
Y GG LG TP L + + V V +G ++ G + W EA
Sbjct: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070
Query: 363 AGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGC 422
G G+ P ++P R +E G+ + VA G +AC+T G + T+G G G
Sbjct: 4071 LGHGNRSP--CDRP------RVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGR 4122
Query: 423 LGHGSLTDISQPTIVEALLGYEMVQVACGA--SHVLALSTERELFAWGRGDSGRLGLGTR 480
LGH D +P +VEAL G+ +V +ACG+ + L L+ + +++WG GD G+LG G
Sbjct: 4123 LGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGS 4182
Query: 481 ESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVP 540
+ P ++ G +V CG S+ LT G G +++LG H S P
Sbjct: 4183 DGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLG--HGSDDHVRRP 4240
Query: 541 HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG 600
Q L + +++I G+ H T G+ YT+G N GQLG T
Sbjct: 4241 RQV------------QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNA 4288
Query: 601 SRAPCKVQGLEGIKMAMVACGDAFTVA 627
+ P V L+G K+ VACG A T+A
Sbjct: 4289 IQRPRLVAALQGKKVNRVACGSAHTLA 4315
Score = 123 bits (308), Expect = 7e-28
Identities = 85/281 (30%), Positives = 137/281 (48%), Gaps = 20/281 (7%)
Query: 365 GGSLLPG-AVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCL 423
GG L G V +P+ IS F Q+G + H+ACG ++A +T G + T+G G+ G L
Sbjct: 524 GGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRL 583
Query: 424 GHGSLTDISQPTIVEALLGYEMVQVACGA--SHVLALSTERELFAWGRGDSGRLGLGTRE 481
GHGS D + P +V L G +++ VACG+ + LA++ ++++WG GD G+LG G +
Sbjct: 584 GHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSD 643
Query: 482 SHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPH 541
P+ + + +V CG S+ LT GQ + G +LG EE V +
Sbjct: 644 GCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHG----TEEHVRY 699
Query: 542 QQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGS 601
++ E L + ++ + G+ H A+T + +++GSN Q R
Sbjct: 700 PKLLEG----------LQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTK 749
Query: 602 RAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGAR 642
P + GL+ + +ACG A + A + SE W G R
Sbjct: 750 PEPAALPGLDTKHIVGIACGPAQSFAWSSCSE---WSIGLR 787
Score = 111 bits (277), Expect = 3e-24
Identities = 76/272 (27%), Positives = 127/272 (46%), Gaps = 28/272 (10%)
Query: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
EG + + + +AC + L+ G + T S D P +V+ L +
Sbjct: 446 EGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS----------DTLAPQLVQGLASRNI 495
Query: 446 VQVACGAS--HVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQR---- 499
V++A + H LAL+ E+++WG GD GRLG G P+ + G++A +
Sbjct: 496 VKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVH 555
Query: 500 VVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLD 559
+ CG S +T G+ G + +LG H S +E +P L L G +D
Sbjct: 556 IACGSTYSAAITAEGELYTWGRGNYGRLG--HGSSEDEAIP------MLVAGLKGLKVID 607
Query: 560 QEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVA 619
++ G A + AVT +G +++G +G+LG G + P ++ L+ + + V
Sbjct: 608 ----VACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVR 663
Query: 620 CGDAFTVAIGAESEVYSWGKGARGRLGRRDED 651
CG F++A+ + +VYSWGKG RLG E+
Sbjct: 664 CGSQFSIALTKDGQVYSWGKGDNQRLGHGTEE 695
Score = 108 bits (271), Expect = 1e-23
Identities = 85/278 (30%), Positives = 128/278 (46%), Gaps = 19/278 (6%)
Query: 400 DFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALS 459
D +T G I +G G LG + PT EAL VQ+ G + A++
Sbjct: 3942 DDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVT 4001
Query: 460 TERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVV--CGIDSSMILTVPGQAL 517
+ +L+A G G GRLG+G ES S P + ++V G + L+ G+
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061
Query: 518 ACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVT 577
+ G KLG + S P +V E+L ++ + G AHSA VT
Sbjct: 4062 SWGEAEDGKLGHGNRS----PCDRPRVIESLRGI----------EVVDVAAGGAHSACVT 4107
Query: 578 ASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVAC--GDAFTVAIGAESEVY 635
A+GD YT+G ++G+LG + P V+ L+G ++ +AC GDA T+ + + V+
Sbjct: 4108 AAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVW 4167
Query: 636 SWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
SWG G G+LGR D G P+++D V V C
Sbjct: 4168 SWGDGDYGKLGRGGSD-GCKVPMKIDSLTGLGVVKVEC 4204
Score = 105 bits (263), Expect = 1e-22
Identities = 89/293 (30%), Positives = 139/293 (47%), Gaps = 22/293 (7%)
Query: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
+G SG I+ A G + T R + +G LG + I P+ E L +
Sbjct: 2937 KGNSGSLIRKKAAG--LESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNV 2994
Query: 446 VQVACGASHVLALSTERELFAWGRGDSGRLGLG-TRESHSCPQQVPMPPGQEAQRVV--C 502
VQVA G+ + A++ E +++A G +GRLGLG + + P+Q+ ++V
Sbjct: 2995 VQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHS 3054
Query: 503 GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP 562
G + LTV G+ + G KLG H S P ++ EAL +
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLG--HFSRMNCDKP--RLIEALK----------TKR 3100
Query: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACG- 621
+ I G++HSAA+T+SG+ YT+G ++G+LG P V+ L G ++ VACG
Sbjct: 3101 IRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160
Query: 622 -DAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSC 673
DA T+A+ E V+SWG G G+LGR + G P ++ + V + C
Sbjct: 3161 RDAQTLALTDEGLVFSWGDGDFGKLGRGGSE-GCNIPQNIERLNGQGVCQIEC 3212
Score = 98.6 bits (244), Expect = 2e-20
Identities = 79/238 (33%), Positives = 108/238 (45%), Gaps = 32/238 (13%)
Query: 294 RCRGIPRGPVRPAIPPPLSSVYAWG----GGLG-----TPLRLPM----LNTEVVQVAAG 340
R R I G A +Y WG G LG T L+ M L V+QVA G
Sbjct: 3100 RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACG 3159
Query: 341 R--TQKAGVTRSGRLILW---EAPPLGAGG--GSLLPGAVEQPQPQFISRFLEGQSGVTI 393
Q +T G + W + LG GG G +P +E+ L GQ +
Sbjct: 3160 SRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER---------LNGQG---V 3207
Query: 394 KHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGAS 453
+ CG F+ LT G++ T+G G LGHGS + +P +VE L G ++V VA GA
Sbjct: 3208 CQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGAL 3267
Query: 454 HVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILT 511
H LA++ +++AWG D G+ G GT + P V GQ+ RV CG S+ T
Sbjct: 3268 HCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWT 3325
Score = 67.0 bits (162), Expect = 6e-11
Identities = 57/195 (29%), Positives = 87/195 (44%), Gaps = 42/195 (21%)
Query: 313 SVYAWGGG----LG--------TPLRLPMLN-TEVVQVAAGRTQKAGVTRSGRLILW--- 356
+V++WG G LG P+++ L VV+V G +T+SG + W
Sbjct: 4165 TVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKG 4224
Query: 357 EAPPLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFG 416
+ LG G V +P R ++G G + +A G C T+ G + T+G
Sbjct: 4225 DYHRLGHGSDD----HVRRP------RQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWG 4274
Query: 417 SGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLG 476
G LG G+ I +P +V AL G ++ +VACG++H LA ST + +G+L
Sbjct: 4275 DNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKP------ASAGKL- 4327
Query: 477 LGTRESHSCPQQVPM 491
P QVPM
Sbjct: 4328 ---------PAQVPM 4333
Score = 65.5 bits (158), Expect = 2e-10
Identities = 49/161 (30%), Positives = 75/161 (46%), Gaps = 22/161 (13%)
Query: 314 VYAWGGG------------LGTPLRLPMLNTE-VVQVAAGRTQKAGVTRSGRLILW-EAP 359
V++WG G P + LN + V Q+ G +T+SG + W +
Sbjct: 3174 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGD 3233
Query: 360 PLGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGS 419
G GS V +PQ + EG G I HVA G +TD G + +G
Sbjct: 3234 YFRLGHGS----DVHVRKPQVV----EGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDND 3285
Query: 420 NGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALST 460
+G G+G+ T +PT+V+ L G ++ +VACG+SH +A +T
Sbjct: 3286 HGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
Score = 43.5 bits (101), Expect = 7e-04
Identities = 28/103 (27%), Positives = 42/103 (40%)
Query: 574 AAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESE 633
+A T + +G N QLG + P + L + + VA G A+ E +
Sbjct: 2953 SAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
Query: 634 VYSWGKGARGRLGRRDEDAGLPRPVQLDETHPYTVTSVSCCHG 676
VY+ G+ GRLG +P P Q+ Y V V+ G
Sbjct: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSG 3055
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 142 bits (359), Expect = 8e-34
Identities = 87/250 (34%), Positives = 132/250 (52%), Gaps = 5/250 (2%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y+ R +G+G F +V L + + V IK I ++ + E Q++KLLNHP++
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHI 86
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
I+ Y+ L I E+A G + +++ N L E F QIL A+ + H H
Sbjct: 87 IKLYQVMETKDMLYIVTEFAKNGEMFDYLTS--NGHLSENEARKKFWQILSAVEYCHDHH 144
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPY-NQ 182
I+HRDLKT+N+LLD + M +K+ DFG S T G+P Y +PE+ EGK Y
Sbjct: 145 IVHRDLKTENLLLDGN-MDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGP 203
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ DIW+LG VLY L F+ NLP L +++ G F I S + L+ +L ++
Sbjct: 204 QLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFR-IPFFMSQDCESLIRRMLVVD 262
Query: 243 PAQRPPLSHI 252
PA+R ++ I
Sbjct: 263 PARRITIAQI 272
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 142 bits (358), Expect = 1e-33
Identities = 85/251 (33%), Positives = 135/251 (53%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L K V +K I Q+ Q E +++K+LNHPN+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + +K T G+P Y +PEL +GK Y+
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILN 288
Query: 243 PAQRPPLSHIM 253
P++R L IM
Sbjct: 289 PSKRGTLEQIM 299
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 142 bits (358), Expect = 1e-33
Identities = 85/251 (33%), Positives = 135/251 (53%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L K V +K I Q+ Q E +++K+LNHPN+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + +K T G+P Y +PEL +GK Y+
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILN 288
Query: 243 PAQRPPLSHIM 253
P++R L IM
Sbjct: 289 PSKRGTLEQIM 299
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 142 bits (358), Expect = 1e-33
Identities = 85/251 (33%), Positives = 135/251 (53%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L K V +K I Q+ Q E +++K+LNHPN+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + +K T G+P Y +PEL +GK Y+
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILN 288
Query: 243 PAQRPPLSHIM 253
P++R L IM
Sbjct: 289 PSKRGTLEQIM 299
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 142 bits (358), Expect = 1e-33
Identities = 85/251 (33%), Positives = 135/251 (53%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L K V +K I Q+ Q E +++K+LNHPN+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 112
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 113 VKLFEVIETEKTLYLVMEYASGGEVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + +K T G+P Y +PEL +GK Y+
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 229
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 230 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILN 288
Query: 243 PAQRPPLSHIM 253
P++R L IM
Sbjct: 289 PSKRGTLEQIM 299
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 142 bits (358), Expect = 1e-33
Identities = 85/251 (33%), Positives = 135/251 (53%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L K V +K I Q+ Q E +++K+LNHPN+
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI 79
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 80 VKLFEVIETEKTLYLVMEYASGGEVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKF 137
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + +K T G+P Y +PEL +GK Y+
Sbjct: 138 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGP 196
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 197 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKFLILN 255
Query: 243 PAQRPPLSHIM 253
P++R L IM
Sbjct: 256 PSKRGTLEQIM 266
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 139 bits (350), Expect = 9e-33
Identities = 85/251 (33%), Positives = 134/251 (53%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y + +G+G F V L + V +K I Q+ Q E +++K+LNHPN+
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 119
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 120 VKLFEVIETEKTLYLVMEYASGGEVFDYLV--AHGRMKEKEARAKFRQIVSAVQYCHQKY 177
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + +K T G+P Y +PEL +GK Y+
Sbjct: 178 IVHRDLKAENLLLDGD-MNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGP 236
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ LL L
Sbjct: 237 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKKLLVLN 295
Query: 243 PAQRPPLSHIM 253
P +R L IM
Sbjct: 296 PIKRGSLEQIM 306
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 139 bits (349), Expect = 1e-32
Identities = 85/251 (33%), Positives = 133/251 (52%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L + V IK I Q+ Q E +++K+LNHPN+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLV--AHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + K T G+P Y +PEL +GK Y+
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKRFLVLN 291
Query: 243 PAQRPPLSHIM 253
P +R L IM
Sbjct: 292 PIKRGTLEQIM 302
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 139 bits (349), Expect = 1e-32
Identities = 85/251 (33%), Positives = 133/251 (52%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L + V IK I Q+ Q E +++K+LNHPN+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLV--AHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + K T G+P Y +PEL +GK Y+
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKRFLVLN 291
Query: 243 PAQRPPLSHIM 253
P +R L IM
Sbjct: 292 PIKRGTLEQIM 302
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 139 bits (349), Expect = 1e-32
Identities = 85/251 (33%), Positives = 133/251 (52%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L + V IK I Q+ Q E +++K+LNHPN+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLV--AHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + K T G+P Y +PEL +GK Y+
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKRFLVLN 291
Query: 243 PAQRPPLSHIM 253
P +R L IM
Sbjct: 292 PIKRGTLEQIM 302
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 139 bits (349), Expect = 1e-32
Identities = 85/251 (33%), Positives = 133/251 (52%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y ++ +G+G F V L + V IK I Q+ Q E +++K+LNHPN+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNI 115
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA GG + +++ + ++E+ F QI+ A+ + H
Sbjct: 116 VKLFEVIETEKTLYLIMEYASGGEVFDYLV--AHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD M +KI DFG S + K T G+P Y +PEL +GK Y+
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGP 232
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ D+W+LG +LY L S F+ NL L +++ G + I S + L+ L L
Sbjct: 233 EVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR-IPFYMSTDCENLLKRFLVLN 291
Query: 243 PAQRPPLSHIM 253
P +R L IM
Sbjct: 292 PIKRGTLEQIM 302
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 139 bits (349), Expect = 1e-32
Identities = 86/252 (34%), Positives = 135/252 (53%), Gaps = 7/252 (2%)
Query: 3 KYERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQA-AQNECQVLKLLNHP 61
+YE +G+G +G V + ++V IK I +++ E+ + E +++ LNHP
Sbjct: 54 RYELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHP 113
Query: 62 NVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHT 121
++I YE F ++I MEYA G L ++I +R L E ET HFF QI+ A+H+ H
Sbjct: 114 HIISIYEVFENKDKIVIIMEYASKGELYDYISER-RRLSERET-RHFFRQIVSAVHYCHK 171
Query: 122 HLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPY- 180
+ ++HRDLK +NILLD + +KI DFG+S + T G+P Y SPE+ G+PY
Sbjct: 172 NGVVHRDLKLENILLDDN-CNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYR 230
Query: 181 NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLS 240
+ D WALG +LY L F+ + L+ +I SG + + R L+ +L
Sbjct: 231 GPEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYR--EPTQPSDARGLIRWMLM 288
Query: 241 LEPAQRPPLSHI 252
+ P +R + I
Sbjct: 289 VNPDRRATIEDI 300
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 139 bits (349), Expect = 1e-32
Identities = 86/251 (34%), Positives = 133/251 (52%), Gaps = 5/251 (1%)
Query: 4 YERIRVVGRGAFGIVHLCLRKADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63
Y +R +G+G F V L + V IK I Q+ Q E +++K LNHPN+
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNI 118
Query: 64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHL 123
++ +E +K L + MEYA G + +++ + ++E+ F QI+ A+H+ H
Sbjct: 119 VKLFEVIETEKTLYLVMEYASAGEVFDYLVS--HGRMKEKEARAKFRQIVSAVHYCHQKN 176
Query: 124 ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYN-Q 182
I+HRDLK +N+LLD +KI DFG S + SK T G+P Y +PEL +GK Y+
Sbjct: 177 IVHRDLKAENLLLDAEAN-IKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGP 235
Query: 183 KSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLE 242
+ DIW+LG +LY L S F+ NL L +++ G + + S + ++ L L
Sbjct: 236 EVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYR-VPFYMSTDCESILRRFLVLN 294
Query: 243 PAQRPPLSHIM 253
PA+R L IM
Sbjct: 295 PAKRCTLEQIM 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,049,652
Number of Sequences: 37866
Number of extensions: 1353172
Number of successful extensions: 7044
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 660
Number of HSP's successfully gapped in prelim test: 188
Number of HSP's that attempted gapping in prelim test: 3736
Number of HSP's gapped (non-prelim): 1242
length of query: 692
length of database: 18,247,518
effective HSP length: 109
effective length of query: 583
effective length of database: 14,120,124
effective search space: 8232032292
effective search space used: 8232032292
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.