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Search of human proteins with 29788755
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29788755 SET binding factor 2 [Homo sapiens]
(1849 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29788755 SET binding factor 2 [Homo sapiens] 3705 0.0
gi|239735519 SET binding factor 1 [Homo sapiens] 2147 0.0
gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens] 174 5e-43
gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens] 174 5e-43
gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens] 174 5e-43
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens] 172 2e-42
gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens] 172 2e-42
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens] 172 2e-42
gi|217272865 myotubularin related protein 4 [Homo sapiens] 161 6e-39
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 152 4e-36
gi|4557896 myotubularin [Homo sapiens] 145 3e-34
gi|28872761 myotubularin-related protein 1 [Homo sapiens] 143 2e-33
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 137 1e-31
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 137 1e-31
gi|225543474 myotubularin related protein 7 [Homo sapiens] 132 4e-30
gi|21361759 myotubularin related protein 8 [Homo sapiens] 129 3e-29
gi|19923424 myotubularin related protein 9 [Homo sapiens] 121 7e-27
gi|134142348 myotubularin related protein 6 [Homo sapiens] 118 5e-26
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 110 1e-23
gi|124028527 myotubularin related protein 10 [Homo sapiens] 110 2e-23
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 105 5e-22
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 101 6e-21
gi|94721263 myotubularin related protein 12 [Homo sapiens] 100 2e-20
gi|224994251 myotubularin related protein 11 isoform a [Homo sap... 92 5e-18
gi|89111941 myotubularin related protein 11 isoform b [Homo sapi... 92 5e-18
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 85 7e-16
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 82 4e-15
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 82 5e-15
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 79 4e-14
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 77 2e-13
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 3705 bits (9609), Expect = 0.0
Identities = 1849/1849 (100%), Positives = 1849/1849 (100%)
Query: 1 MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER 60
MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER
Sbjct: 1 MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER 60
Query: 61 KQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKS 120
KQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKS
Sbjct: 61 KQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKS 120
Query: 121 LVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGD 180
LVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGD
Sbjct: 121 LVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGD 180
Query: 181 RQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRA 240
RQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRA
Sbjct: 181 RQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRA 240
Query: 241 LESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI 300
LESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI
Sbjct: 241 LESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI 300
Query: 301 KIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFL 360
KIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFL
Sbjct: 301 KIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFL 360
Query: 361 RLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER 420
RLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER
Sbjct: 361 RLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER 420
Query: 421 GPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRP 480
GPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRP
Sbjct: 421 GPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRP 480
Query: 481 TEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKV 540
TEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKV
Sbjct: 481 TEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKV 540
Query: 541 TTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNR 600
TTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNR
Sbjct: 541 TTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNR 600
Query: 601 AILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDH 660
AILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDH
Sbjct: 601 AILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDH 660
Query: 661 PIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQ 720
PIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQ
Sbjct: 661 PIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQ 720
Query: 721 LRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESG 780
LRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESG
Sbjct: 721 LRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESG 780
Query: 781 SNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSL 840
SNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSL
Sbjct: 781 SNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSL 840
Query: 841 HCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREE 900
HCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREE
Sbjct: 841 HCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREE 900
Query: 901 ATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQN 960
ATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQN
Sbjct: 901 ATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQN 960
Query: 961 QLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQT 1020
QLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQT
Sbjct: 961 QLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQT 1020
Query: 1021 TPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNE 1080
TPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNE
Sbjct: 1021 TPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNE 1080
Query: 1081 DDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRI 1140
DDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRI
Sbjct: 1081 DDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRI 1140
Query: 1141 TASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGF 1200
TASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGF
Sbjct: 1141 TASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGF 1200
Query: 1201 HGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAF 1260
HGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAF
Sbjct: 1201 HGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAF 1260
Query: 1261 ALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFG 1320
ALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFG
Sbjct: 1261 ALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFG 1320
Query: 1321 EKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDS 1380
EKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDS
Sbjct: 1321 EKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDS 1380
Query: 1381 EWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQM 1440
EWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQM
Sbjct: 1381 EWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQM 1440
Query: 1441 LVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFL 1500
LVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFL
Sbjct: 1441 LVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFL 1500
Query: 1501 AFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLY 1560
AFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLY
Sbjct: 1501 AFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLY 1560
Query: 1561 SPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQ 1620
SPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQ
Sbjct: 1561 SPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQ 1620
Query: 1621 RRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRS 1680
RRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRS
Sbjct: 1621 RRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRS 1680
Query: 1681 QRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKN 1740
QRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKN
Sbjct: 1681 QRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKN 1740
Query: 1741 DENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPA 1800
DENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPA
Sbjct: 1741 DENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPA 1800
Query: 1801 GPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA 1849
GPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA
Sbjct: 1801 GPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA 1849
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 2147 bits (5562), Expect = 0.0
Identities = 1116/1909 (58%), Positives = 1399/1909 (73%), Gaps = 76/1909 (3%)
Query: 1 MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER 60
MARLADYF++V + GSGEG G+I+QRFP+KDW+D PFPQGIELFCQP GWQL ER
Sbjct: 1 MARLADYFVLVAFGPHPRGSGEGQGQILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER 60
Query: 61 KQPTFFVVVLTDIDSDRHYCSCLTFYE-AEINLQGTKKE-----EIEGEAKVSGLIQP-- 112
PTFFV VLTDI+S+RHYC+CLTF+E AE + + T+ E E EG+ + P
Sbjct: 61 NPPTFFVAVLTDINSERHYCACLTFWEPAEPSQETTRVEDATEREEEGDEGGQTHLSPTA 120
Query: 113 ----AEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAG 168
A++FAPK+LVLVSRL + E+FR LGLIY ++V+ LNV LE++I NL C VP AG
Sbjct: 121 PAPSAQLFAPKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTCTVPLAG 180
Query: 169 GSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHS 228
GSQ+ SLGAGDRQ+IQTPL DSLP++ SVALLF+QLGI NVLSLFCA LTE+KVLF S
Sbjct: 181 GSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLFCAALTEHKVLFLS 240
Query: 229 ASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELL 288
S+QRL+DACR L +L+FPL+YS+ Y+PILPAQLLEVLS+PTPFIIGV++ F+ + ELL
Sbjct: 241 RSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELL 300
Query: 289 DVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHS 348
DVI+ADLDGGT+ IPEC+H+ LPEPL QT S LS++L P+LE+AD AFPPP T+ S
Sbjct: 301 DVIVADLDGGTVTIPECVHIPPLPEPLQSQTHSVLSMVLDPELELADLAFPPPTTSTSSL 360
Query: 349 KMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVL 408
KM DKE+RAVFLRLFAQL QGYR CL ++RIH EPVI FHK AFLGQRGLVE+DFL KVL
Sbjct: 361 KMQDKELRAVFLRLFAQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQRGLVEDDFLMKVL 420
Query: 409 SGMAFAGFVSERGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENP 468
GMAFAGFVSERG PYR DLFDELVA EV R++ +EN+P ++++HV+ELAEQL+KNENP
Sbjct: 421 EGMAFAGFVSERGVPYRPTDLFDELVAHEVARMRADENHPQRVLRHVQELAEQLYKNENP 480
Query: 469 NPHMAFQKVPRPTEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVP 528
P +A KV RP E SHLR PFP ++E VQ ++ + AK Q APPA + E++ VP
Sbjct: 481 YPAVAMHKVQRPGESSHLRRVPRPFPRLDEGTVQWIVDQAAAKMQGAPPAVKAERRTTVP 540
Query: 529 AGPPVVSIMDKVTTVF-NSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQC 587
+GPP+ +I+++ + + NSA+RLEVVRNCIS++FE K+LE +K LPA LRALKG+AAR+C
Sbjct: 541 SGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRC 600
Query: 588 LTDELGLHVQQNRAILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAP 647
L EL LHVQQNRA+LDHQQFD+++RMMNC LQDC+SL+E+ IAAALLPL +AF RKL+P
Sbjct: 601 LAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLDEHGIAAALLPLVTAFCRKLSP 660
Query: 648 GVSQFAYTCVQDHPIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDH 707
GV+QFAY+CVQ+H +W+ QFWE FY VQ +R+LYL ED AP ++ + P
Sbjct: 661 GVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDL-AP-AQEVGEAPSQE 718
Query: 708 YQEKTAMDLAAEQLRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNK 767
E++A+D+A+EQ RLWPTLS+ QQELVQ EESTVFSQAIH+AN M LL+PLD+SK++
Sbjct: 719 -DERSALDVASEQRRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSR 777
Query: 768 LLRTSAP-GDWESGSNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKV 826
LLR A GD ES SNS+VTNS+AGSVAESYDTESGFED+E D+A +VVRFI RF+DKV
Sbjct: 778 LLRERAGLGDLESASNSLVTNSMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKV 837
Query: 827 CTESGVTQDHIKSLHCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVC 886
CTESGVT DH+K LH M+P IV MHIETLEAV RESRRLPPIQKPK+LRP LLPGEE V
Sbjct: 838 CTESGVTSDHLKGLHVMVPDIVQMHIETLEAVQRESRRLPPIQKPKLLRPRLLPGEECVL 897
Query: 887 EGLRVLLDPDGREEATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFP 946
+GLRV L PDGREE GG GGP LLPAEGA+FLTTYR++F G P D LVGEQ VVRSFP
Sbjct: 898 DGLRVYLLPDGREEGAGGSAGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFP 957
Query: 947 IASITKEKKITMQNQLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYP 1006
+A++TKEK+I++Q + Q +Q+GLQ+ S +FQL+K+AFDEEV + E+F+KQL K RYP
Sbjct: 958 VAALTKEKRISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFRKQLHKLRYP 1017
Query: 1007 QSIFSTFAFAAGQT-TPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKT 1065
I +TFAF G TP K+K S RT S+ +VK AK+ TIGRQ++ +KK
Sbjct: 1018 PDIRATFAFTLGSAHTPGRPPRVTKDKGPSLRTLSRNLVKNAKK----TIGRQHVTRKKY 1073
Query: 1066 GTIV-EERVNRPGWNEDDDVSVSDESE---LPTSTTLKASEKSTMEQLVEKACFRDYQRL 1121
E R P +++D++SVS+E E L S+ LK S++ TM LVE+AC RDYQRL
Sbjct: 1074 NPPSWEHRGQPPPEDQEDEISVSEELEPSTLTPSSALKPSDRMTMSSLVERACCRDYQRL 1133
Query: 1122 GLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLP 1181
GLGT+S S SR++ E FRI+ NRMY++CRSYPGLL+VPQ+VQD++L RV+RCYR NR P
Sbjct: 1134 GLGTLSSSLSRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFP 1193
Query: 1182 VVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNA 1241
VVCW++ RS +LLRSGG HGKGVVGLFK+QN+P +P S SSS+EQEKYLQA++++
Sbjct: 1194 VVCWRSGRSKAVLLRSGGLHGKGVVGLFKAQNAP--SPGQSQADSSSLEQEKYLQAVVSS 1251
Query: 1242 VSVHQKLRGNSTL--------------------TVRPAFALSP-------GVWASLRSST 1274
+ + G +TL T+ A S G W S+R+S
Sbjct: 1252 MPRYADASGRNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRTSG 1311
Query: 1275 RLISSPTSFIDVGARLAGKDHSAS-FSNSSYLQNQLLKRQ-AALYIFGEKSQLRNFKVEF 1332
R T DVG+RLAG+D A +N L+ Q AALYI G+K+QL+ + +
Sbjct: 1312 RSSGLGT---DVGSRLAGRDALAPPQANGGPPDPGFLRPQRAALYILGDKAQLKGVRSDP 1368
Query: 1333 ALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTD-SEVTFLKALGDSEWFPQLHRIMQ 1391
E VP+E E RQVKASFKKL++AC+P + S +FL++L DSEW Q+H+++Q
Sbjct: 1369 LQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQ 1428
Query: 1392 LAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGH 1451
++V+V E+L++GSSVLV LE+GWDIT QV SLVQLLSDPFYRTLEGF++LVEKEWLSFGH
Sbjct: 1429 VSVLVVELLDSGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGH 1488
Query: 1452 KFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKT 1511
+FS R + TL Q SGF PVFLQFLDCVHQVH Q+P EFEF+ +YLKFL +H+VS RF+T
Sbjct: 1489 RFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRT 1548
Query: 1512 FLLDSDYERLEHGTLFDDKGEKHAKKGV-CIWECIDRMHKRSPIFFNYLYSPLEIEALKP 1570
FLLDSDYER+E G L+++KGE+ + +WE +DR+ KR+P+F NY+Y+P + E L+P
Sbjct: 1549 FLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRP 1608
Query: 1571 NVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQRRTVWPCYDD 1630
NVS+LK WD+Y EETL+ GP YDW + P E+ G A P+S+RR VWPCYD
Sbjct: 1609 YSNVSNLKVWDFYTEETLAEGPPYDWELAQGPPEPPEEERSDGGA-PQSRRRVVWPCYDS 1667
Query: 1631 VSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTD----------RS 1680
QPDA++ L E+++LE +L Q E+W+ W+RV + E R D +
Sbjct: 1668 CPRAQPDAISRLLEELQRLETELGQPAERWKDTWDRVKAAQRLEGRPDGRGTPSSLLVST 1727
Query: 1681 QRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKN 1740
H RS G+ P SL D S G + S R +TLYSQ+ +
Sbjct: 1728 APHHRRSLGVYLQEGPVGSTLSLSLDSDQSSGSTTSGS---RQAARRSTSTLYSQFQTAE 1784
Query: 1741 DENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPA 1800
ENRS+EGTLYK+GA +K WK RWFVLD TKHQLRYYD DT CKG IDLAEVE V P
Sbjct: 1785 SENRSYEGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDTECKGVIDLAEVEAVAPG 1844
Query: 1801 GPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA 1849
P+MGAPK +KAFFD+KT++RVYNFCAQD SAQQW+D+IQSC+SDA
Sbjct: 1845 TPTMGAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRIQSCLSDA 1893
>gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]
Length = 643
Score = 174 bits (442), Expect = 5e-43
Identities = 136/452 (30%), Positives = 198/452 (43%), Gaps = 96/452 (21%)
Query: 1136 EYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLL 1195
E +RIT N Y LC +YP LLVVP + D L RVA R+PV+ W + S +
Sbjct: 223 ESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATIT 282
Query: 1196 RSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLT 1255
R + P + S E EKYLQA++++ + K+
Sbjct: 283 RC-------------------SQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIF------ 317
Query: 1256 VRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAA 1315
F P V A +A K + + QN
Sbjct: 318 ---IFDARPSVNA---------------------VANKAKGGGYESEDAYQN-------- 345
Query: 1316 LYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLK 1375
E V ++ H I ++ S +KL P+ E +L
Sbjct: 346 --------------------AELVFLDIHNIHVMRESLRKLKEIVYPNI----EETHWLS 381
Query: 1376 ALGDSEWFPQLHRIMQLAVVVSEVLENG-SSVLVCLEEGWDITAQVTSLVQLLSDPFYRT 1434
L + W + I+ A+ +++ +E+G +SV+V +GWD TAQ+TSL L+ D +YRT
Sbjct: 382 NLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRT 441
Query: 1435 LEGFQMLVEKEWLSFGHKFSQR-SSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFN 1493
+ GF++LVEKEWLSFGH+F R N + +PVFLQF+DCV Q+ Q+PT FEFN
Sbjct: 442 IRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFN 501
Query: 1494 LYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSP 1553
Y+L + H S F TFL +S+ +R + E K+ V +W I + +
Sbjct: 502 EYFLITILDHLYSCLFGTFLCNSEQQRGK---------ENLPKRTVSLWSYI---NSQLE 549
Query: 1554 IFFNYLYSPLEIEALKPNVNVSSLKKW-DYYI 1584
F N LY L P ++ L+ W YYI
Sbjct: 550 DFTNPLYGSYSNHVLYPVASMRHLELWVGYYI 581
>gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 174 bits (442), Expect = 5e-43
Identities = 136/452 (30%), Positives = 198/452 (43%), Gaps = 96/452 (21%)
Query: 1136 EYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLL 1195
E +RIT N Y LC +YP LLVVP + D L RVA R+PV+ W + S +
Sbjct: 151 ESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATIT 210
Query: 1196 RSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLT 1255
R + P + S E EKYLQA++++ + K+
Sbjct: 211 RC-------------------SQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIF------ 245
Query: 1256 VRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAA 1315
F P V A +A K + + QN
Sbjct: 246 ---IFDARPSVNA---------------------VANKAKGGGYESEDAYQN-------- 273
Query: 1316 LYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLK 1375
E V ++ H I ++ S +KL P+ E +L
Sbjct: 274 --------------------AELVFLDIHNIHVMRESLRKLKEIVYPNI----EETHWLS 309
Query: 1376 ALGDSEWFPQLHRIMQLAVVVSEVLENG-SSVLVCLEEGWDITAQVTSLVQLLSDPFYRT 1434
L + W + I+ A+ +++ +E+G +SV+V +GWD TAQ+TSL L+ D +YRT
Sbjct: 310 NLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRT 369
Query: 1435 LEGFQMLVEKEWLSFGHKFSQR-SSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFN 1493
+ GF++LVEKEWLSFGH+F R N + +PVFLQF+DCV Q+ Q+PT FEFN
Sbjct: 370 IRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFN 429
Query: 1494 LYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSP 1553
Y+L + H S F TFL +S+ +R + E K+ V +W I + +
Sbjct: 430 EYFLITILDHLYSCLFGTFLCNSEQQRGK---------ENLPKRTVSLWSYI---NSQLE 477
Query: 1554 IFFNYLYSPLEIEALKPNVNVSSLKKW-DYYI 1584
F N LY L P ++ L+ W YYI
Sbjct: 478 DFTNPLYGSYSNHVLYPVASMRHLELWVGYYI 509
>gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 174 bits (442), Expect = 5e-43
Identities = 136/452 (30%), Positives = 198/452 (43%), Gaps = 96/452 (21%)
Query: 1136 EYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLL 1195
E +RIT N Y LC +YP LLVVP + D L RVA R+PV+ W + S +
Sbjct: 151 ESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATIT 210
Query: 1196 RSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLT 1255
R + P + S E EKYLQA++++ + K+
Sbjct: 211 RC-------------------SQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIF------ 245
Query: 1256 VRPAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAA 1315
F P V A +A K + + QN
Sbjct: 246 ---IFDARPSVNA---------------------VANKAKGGGYESEDAYQN-------- 273
Query: 1316 LYIFGEKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLK 1375
E V ++ H I ++ S +KL P+ E +L
Sbjct: 274 --------------------AELVFLDIHNIHVMRESLRKLKEIVYPNI----EETHWLS 309
Query: 1376 ALGDSEWFPQLHRIMQLAVVVSEVLENG-SSVLVCLEEGWDITAQVTSLVQLLSDPFYRT 1434
L + W + I+ A+ +++ +E+G +SV+V +GWD TAQ+TSL L+ D +YRT
Sbjct: 310 NLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRT 369
Query: 1435 LEGFQMLVEKEWLSFGHKFSQR-SSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFN 1493
+ GF++LVEKEWLSFGH+F R N + +PVFLQF+DCV Q+ Q+PT FEFN
Sbjct: 370 IRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFN 429
Query: 1494 LYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSP 1553
Y+L + H S F TFL +S+ +R + E K+ V +W I + +
Sbjct: 430 EYFLITILDHLYSCLFGTFLCNSEQQRGK---------ENLPKRTVSLWSYI---NSQLE 477
Query: 1554 IFFNYLYSPLEIEALKPNVNVSSLKKW-DYYI 1584
F N LY L P ++ L+ W YYI
Sbjct: 478 DFTNPLYGSYSNHVLYPVASMRHLELWVGYYI 509
>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
Length = 1161
Score = 172 bits (437), Expect = 2e-42
Identities = 136/455 (29%), Positives = 208/455 (45%), Gaps = 70/455 (15%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+RI+ N Y LC SYP L+VP + D L V+ R+P V +++ +G ++ R
Sbjct: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
Query: 1198 GGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVR 1257
G P S + + E +Q++ A + + G+ T
Sbjct: 236 G-------------------QPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLST-- 274
Query: 1258 PAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALY 1317
R+++R + G L+ + +S SN+S ++ ++ Q L
Sbjct: 275 -------------RNTSRDFPN-------GGDLSDVEFDSSLSNASGAESLAIQPQKLLI 314
Query: 1318 IFGEK--SQLRNFKV-------EFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTD 1368
+ + + N E+ NCE V + I ++ SF+ L C P +
Sbjct: 315 LDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGN 374
Query: 1369 SEVTFLKALGDSEWFPQLHRIMQLAV-VVSEVLENGSSVLVCLEEGWDITAQVTSLVQLL 1427
+L AL ++W L +++ A+ VV V ++ VLV +GWD T Q+ +L +LL
Sbjct: 375 ----WLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLL 430
Query: 1428 SDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQG-SGFAPVFLQFLDCVHQVHNQY 1486
DP+YRT+EGFQ+LVE EWL FGHKF+ R N + PVFLQ+LDCVHQ+ Q+
Sbjct: 431 LDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQF 490
Query: 1487 PTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVC-IWECI 1545
P FEFN +L L H S F TFL ++ ER GEKH ++ C +W +
Sbjct: 491 PCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER----------GEKHTQERTCSVWSLL 540
Query: 1546 DRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKW 1580
+K F N LYS L P +V +L W
Sbjct: 541 RAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572
>gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]
Length = 1170
Score = 172 bits (437), Expect = 2e-42
Identities = 136/455 (29%), Positives = 208/455 (45%), Gaps = 70/455 (15%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+RI+ N Y LC SYP L+VP + D L V+ R+P V +++ +G ++ R
Sbjct: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
Query: 1198 GGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVR 1257
G P S + + E +Q++ A + + G+ T
Sbjct: 236 G-------------------QPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLST-- 274
Query: 1258 PAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALY 1317
R+++R + G L+ + +S SN+S ++ ++ Q L
Sbjct: 275 -------------RNTSRDFPN-------GGDLSDVEFDSSLSNASGAESLAIQPQKLLI 314
Query: 1318 IFGEK--SQLRNFKV-------EFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTD 1368
+ + + N E+ NCE V + I ++ SF+ L C P +
Sbjct: 315 LDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGN 374
Query: 1369 SEVTFLKALGDSEWFPQLHRIMQLAV-VVSEVLENGSSVLVCLEEGWDITAQVTSLVQLL 1427
+L AL ++W L +++ A+ VV V ++ VLV +GWD T Q+ +L +LL
Sbjct: 375 ----WLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLL 430
Query: 1428 SDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQG-SGFAPVFLQFLDCVHQVHNQY 1486
DP+YRT+EGFQ+LVE EWL FGHKF+ R N + PVFLQ+LDCVHQ+ Q+
Sbjct: 431 LDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQF 490
Query: 1487 PTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVC-IWECI 1545
P FEFN +L L H S F TFL ++ ER GEKH ++ C +W +
Sbjct: 491 PCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER----------GEKHTQERTCSVWSLL 540
Query: 1546 DRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKW 1580
+K F N LYS L P +V +L W
Sbjct: 541 RAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572
>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
Length = 1198
Score = 172 bits (437), Expect = 2e-42
Identities = 136/455 (29%), Positives = 208/455 (45%), Gaps = 70/455 (15%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+RI+ N Y LC SYP L+VP + D L V+ R+P V +++ +G ++ R
Sbjct: 176 WRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARC 235
Query: 1198 GGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVR 1257
G P S + + E +Q++ A + + G+ T
Sbjct: 236 G-------------------QPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLST-- 274
Query: 1258 PAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALY 1317
R+++R + G L+ + +S SN+S ++ ++ Q L
Sbjct: 275 -------------RNTSRDFPN-------GGDLSDVEFDSSLSNASGAESLAIQPQKLLI 314
Query: 1318 IFGEK--SQLRNFKV-------EFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTD 1368
+ + + N E+ NCE V + I ++ SF+ L C P +
Sbjct: 315 LDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGN 374
Query: 1369 SEVTFLKALGDSEWFPQLHRIMQLAV-VVSEVLENGSSVLVCLEEGWDITAQVTSLVQLL 1427
+L AL ++W L +++ A+ VV V ++ VLV +GWD T Q+ +L +LL
Sbjct: 375 ----WLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLL 430
Query: 1428 SDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQG-SGFAPVFLQFLDCVHQVHNQY 1486
DP+YRT+EGFQ+LVE EWL FGHKF+ R N + PVFLQ+LDCVHQ+ Q+
Sbjct: 431 LDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQF 490
Query: 1487 PTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVC-IWECI 1545
P FEFN +L L H S F TFL ++ ER GEKH ++ C +W +
Sbjct: 491 PCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKER----------GEKHTQERTCSVWSLL 540
Query: 1546 DRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKW 1580
+K F N LYS L P +V +L W
Sbjct: 541 RAGNK---AFKNLLYSSQSEAVLYPVCHVRNLMLW 572
>gi|217272865 myotubularin related protein 4 [Homo sapiens]
Length = 1195
Score = 161 bits (407), Expect = 6e-39
Identities = 134/448 (29%), Positives = 201/448 (44%), Gaps = 60/448 (13%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+R++ N Y LC SYP L+VP + D L VA R+PVV +++ R+G + R
Sbjct: 174 WRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARC 233
Query: 1198 GGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVR 1257
+ P S + + E YL ++
Sbjct: 234 -------------------SQPEISWWGWRNADDE-YL-----------------VTSIA 256
Query: 1258 PAFALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALY 1317
A AL PG A+ S + + + D A + S S+ +LL A Y
Sbjct: 257 KACALDPGTRATGGSLSTGNNDTSEACD--ADFDSSLTACSGVESTAAPQKLLILDARSY 314
Query: 1318 IFGEKSQLRNFKVE---FALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFL 1374
++ + E + NCE V + I ++ SF+ L C S +P S +L
Sbjct: 315 TAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVC--SQMPDPSN--WL 370
Query: 1375 KALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVLVCLEEGWDITAQVTSLVQLLSDPFYR 1433
AL ++W L +++ AV+V+ ++ G VLV +GWD T Q+ +L ++L DP+YR
Sbjct: 371 SALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYR 430
Query: 1434 TLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQGSG-FAPVFLQFLDCVHQVHNQYPTEFEF 1492
TLEGFQ+LVE +WL FGHKF R N + PVFLQ+LD VHQ+ Q+P FEF
Sbjct: 431 TLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEF 490
Query: 1493 NLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRS 1552
N +L L H S + TFL ++ ER + K+ +W + +K
Sbjct: 491 NEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIY---------KRTCSVWALLRAGNKN- 540
Query: 1553 PIFFNYLYSPLEIEALKPNVNVSSLKKW 1580
F N+LY+P L P +V +L W
Sbjct: 541 --FHNFLYTPSSDMVLHPVCHVRALHLW 566
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 152 bits (383), Expect = 4e-36
Identities = 133/461 (28%), Positives = 210/461 (45%), Gaps = 49/461 (10%)
Query: 26 KIIQRFPQKDWDDTPFPQGIELFCQPGG-----WQLSRERKQPTFFVVVLTDIDSDRHYC 80
+++ R+P++D + P P+ + +FC P G W + P F VLT D+ Y
Sbjct: 214 ELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTGAAGDKVYG 273
Query: 81 SCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAE---------VFAPKSLVLVSRLYYPE 131
+ L FYEA + E +A+ GL+ E V + +++ ++SR
Sbjct: 274 AALQFYEAF-----PRARLSERQARALGLLSAVERGRALGGRAVRSRRAIAVLSRWPAFP 328
Query: 132 IFRACLGLIYTVYVDSLN-VSLESLIANLCACL-VPAAGGSQKLFSLGAGDRQLIQTPLH 189
FRA L +Y V + + LE+ I++ + P+ + L + D L+ P+
Sbjct: 329 AFRAFLTFLYRYSVSGPHRLPLEAHISHFIHNVPFPSPQRPRILVQMSPYDNLLLCQPVS 388
Query: 190 DSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLK 249
LP++G S L Q LG + ++L AVLTE+K+L HS L+ C AL S++FPL
Sbjct: 389 SPLPLSGASFLQLLQSLGPELAITLLLAVLTEHKLLVHSLRPDLLTSVCEALVSMIFPLH 448
Query: 250 YSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHE-LLDVIIADLDGGTIKIPECIHL 308
+ PYIP+ P L +VLS+P PFI+G+HS + D+H+ DVI DLD T+ E L
Sbjct: 449 WQCPYIPLCPLVLADVLSAPVPFIVGIHSSY-FDLHDPPADVICVDLDTNTLFQTEEKKL 507
Query: 309 SSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALS-------------HSKMLDKEV 355
S P L + L L + D + P S L++EV
Sbjct: 508 LS-PRTLPRRPYKVLLATLTNLYQQLDQTYTGPEEEASLEFLLTDYEAVCGRRARLEREV 566
Query: 356 RAVFLRLFAQLFQGYRSCLQ-LIRIHAEPVIH----FHKTAFLGQRGLVENDFLTKVLSG 410
+ FLR A L +GYR L+ L + +E F FL R + +++L
Sbjct: 567 QGAFLRFMACLLKGYRVFLRPLTQAPSEGARDVDNLFFLQGFLKSRERSSHKLYSQLLHT 626
Query: 411 MAFAGFVSE---RGPPYRSCDLFDELVAFEVERIKVEENNP 448
F+ F+ E + + + FD VE++ E+ P
Sbjct: 627 QMFSQFIEECSFGSARHAALEFFDSC----VEKVHPEQEKP 663
>gi|4557896 myotubularin [Homo sapiens]
Length = 603
Score = 145 bits (367), Expect = 3e-34
Identities = 89/253 (35%), Positives = 139/253 (54%), Gaps = 19/253 (7%)
Query: 1335 NCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAV 1394
N E ++ H I ++ S KK+ P+ E +L +L + W + ++ A+
Sbjct: 303 NAELFFLDIHNIHVMRESLKKVKDIVYPNV----EESHWLSSLESTHWLEHIKLVLTGAI 358
Query: 1395 VVSEVLENG-SSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKF 1453
V++ + +G SSVLV +GWD TAQ+TSL L+ D FYR++EGF++LV+KEW+SFGHKF
Sbjct: 359 QVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKF 418
Query: 1454 SQR-SSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTF 1512
+ R N + +P+FLQF+DCV Q+ Q+PT FEFN +L + H S RF TF
Sbjct: 419 ASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTF 478
Query: 1513 LLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNV 1572
L + + R + +K ++ V +W I+ ++ F N Y+ L P
Sbjct: 479 LFNCESAR---------ERQKVTERTVSLWSLINSNKEK---FKNPFYTKEINRVLYPVA 526
Query: 1573 NVSSLKKW-DYYI 1584
++ L+ W +YYI
Sbjct: 527 SMRHLELWVNYYI 539
Score = 56.2 bits (134), Expect = 3e-07
Identities = 26/60 (43%), Positives = 37/60 (61%)
Query: 1137 YFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLR 1196
++RIT N+ Y LC +YP LLVVP D L RVA NR+PV+ W + + T+++R
Sbjct: 182 HWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVR 241
>gi|28872761 myotubularin-related protein 1 [Homo sapiens]
Length = 665
Score = 143 bits (360), Expect = 2e-33
Identities = 89/255 (34%), Positives = 138/255 (54%), Gaps = 23/255 (9%)
Query: 1335 NCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAV 1394
N E V +E H I ++ S +KL PS E +L + + W + ++ AV
Sbjct: 366 NAELVFLEIHNIHVMRESLRKLKEIVYPSI----DEARWLSNVDGTHWLEYIRMLLAGAV 421
Query: 1395 VVSEVLENG-SSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKF 1453
+++ +E+G +SV+V +GWD TAQ+TSL L+ D +YRT++GF+ LVEKEW+SFGH+F
Sbjct: 422 RIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRF 481
Query: 1454 SQR-SSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTF 1512
+ R N + +P+FLQF+DCV Q+ Q+P+ FEFN +L + H S F TF
Sbjct: 482 ALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTF 541
Query: 1513 LLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRM--HKRSPIFFNYLYSPLEIEALKP 1570
L + + +R + E K + +W I+ +P F NY E L P
Sbjct: 542 LCNCEQQRFK---------EDVYTKTISLWSYINSQLDEFSNPFFVNY-----ENHVLYP 587
Query: 1571 NVNVSSLKKW-DYYI 1584
++S L+ W +YY+
Sbjct: 588 VASLSHLELWVNYYV 602
Score = 50.1 bits (118), Expect = 2e-05
Identities = 32/113 (28%), Positives = 50/113 (44%), Gaps = 19/113 (16%)
Query: 1136 EYFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLL 1195
E ++I+ N Y C +YP ++VVP +V+D L +VA R+PV+ W + S +
Sbjct: 244 ESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQATIT 303
Query: 1196 RSGGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKL 1248
R + P P E EKYLQ +++A + KL
Sbjct: 304 RC---------------SQPLVGP----NDKRCKEDEKYLQTIMDANAQSHKL 337
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 137 bits (345), Expect = 1e-31
Identities = 122/475 (25%), Positives = 208/475 (43%), Gaps = 47/475 (9%)
Query: 27 IIQRFPQKDWDDTPFPQGIELFCQPGG-----WQLSRERKQPTFFVVVLTDIDSDRHYCS 81
+I R+PQ+D++ P+ + LFC P G W + + P F VLT +++ Y +
Sbjct: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
Query: 82 CLTFYEAEINLQGTKKEEIE-GEAKVSGLIQPAE-VFAPKSLVLVSRLYYPEIFRACLGL 139
+ FYE T+K+ + G G ++ + K + L+S + + FR L
Sbjct: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
Query: 140 IYTVYVDSLNV-SLESLIANLCACL-VPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGT 197
+Y + +V +E I++ + P+ + L L D ++ P+ LP++G
Sbjct: 332 LYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGG 391
Query: 198 SVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPI 257
+ L Q LG +N ++L +TE+K+L HS L+ AL S++FP + PY+P+
Sbjct: 392 KFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPL 451
Query: 258 LPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI-----------KIPECI 306
P L +VLS+P PFI+G+ S + DV D+D TI KI
Sbjct: 452 CPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKK 511
Query: 307 HLSSLPEPLLHQTQSALSLILHP------DLEVADHAFPPPRTALSHSKMLDKEVRAVFL 360
+L L + Q L P DL + D+ F + M+D E++ FL
Sbjct: 512 PCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKRLHMIDLEIQEAFL 567
Query: 361 RLFAQLFQGYRSCLQLI-----RIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAG 415
A + +GYRS L+ I + F AFL R F + F
Sbjct: 568 FFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIR 627
Query: 416 FVSE---RGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNEN 467
F+ E S FD+ V+++ ++++ V++I+ ++ FK+E+
Sbjct: 628 FIEECSFVSDKDASLAFFDDC----VDKVDMDKSGEVRLIE-----LDESFKSEH 673
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 137 bits (345), Expect = 1e-31
Identities = 122/475 (25%), Positives = 208/475 (43%), Gaps = 47/475 (9%)
Query: 27 IIQRFPQKDWDDTPFPQGIELFCQPGG-----WQLSRERKQPTFFVVVLTDIDSDRHYCS 81
+I R+PQ+D++ P+ + LFC P G W + + P F VLT +++ Y +
Sbjct: 212 LICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTGASAEKVYGA 271
Query: 82 CLTFYEAEINLQGTKKEEIE-GEAKVSGLIQPAE-VFAPKSLVLVSRLYYPEIFRACLGL 139
+ FYE T+K+ + G G ++ + K + L+S + + FR L
Sbjct: 272 AIQFYEPYSEENLTEKQRLLLGLTSADGKSDSSKTIHTNKCICLLSHWPFFDAFRKFLTF 331
Query: 140 IYTVYVDSLNV-SLESLIANLCACL-VPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGT 197
+Y + +V +E I++ + P+ + L L D ++ P+ LP++G
Sbjct: 332 LYRYSISGPHVLPIEKHISHFMHKVPFPSPQRPRILVQLSPHDNLILSQPVSSPLPLSGG 391
Query: 198 SVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPI 257
+ L Q LG +N ++L +TE+K+L HS L+ AL S++FP + PY+P+
Sbjct: 392 KFSTLLQNLGPENAVTLLVFAVTEHKILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPL 451
Query: 258 LPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI-----------KIPECI 306
P L +VLS+P PFI+G+ S + DV D+D TI KI
Sbjct: 452 CPLALADVLSAPCPFIVGIDSRYFDLYDPPPDVSCVDVDTNTISQIGDKKNVAWKILPKK 511
Query: 307 HLSSLPEPLLHQTQSALSLILHP------DLEVADHAFPPPRTALSHSKMLDKEVRAVFL 360
+L L + Q L P DL + D+ F + M+D E++ FL
Sbjct: 512 PCKNLMNTLNNLHQQLAKLQQRPRDDGLMDLAINDYDF----NSGKRLHMIDLEIQEAFL 567
Query: 361 RLFAQLFQGYRSCLQLI-----RIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAG 415
A + +GYRS L+ I + F AFL R F + F
Sbjct: 568 FFMASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQMFIR 627
Query: 416 FVSE---RGPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNEN 467
F+ E S FD+ V+++ ++++ V++I+ ++ FK+E+
Sbjct: 628 FIEECSFVSDKDASLAFFDDC----VDKVDMDKSGEVRLIE-----LDESFKSEH 673
>gi|225543474 myotubularin related protein 7 [Homo sapiens]
Length = 660
Score = 132 bits (331), Expect = 4e-30
Identities = 74/189 (39%), Positives = 108/189 (57%), Gaps = 5/189 (2%)
Query: 1335 NCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAV 1394
N +F + I ++ S +K++ C + + S FL L +S W + IM +
Sbjct: 265 NIKFQFIGIENIHVMRNSLQKMLEVC---ELKSPSMSDFLWGLENSGWLRHIKAIMDAGI 321
Query: 1395 VVSE-VLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKF 1453
+++ V E G+SVLV +GWD TAQV S+ LL DP YRTL+GF +L+EK+W+SFGHKF
Sbjct: 322 FIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKF 381
Query: 1454 SQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFL 1513
+ R L+ +PV QF++CV Q+ Q+P FEFN +L + H S +F FL
Sbjct: 382 NHRYG-NLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFL 440
Query: 1514 LDSDYERLE 1522
+S ER E
Sbjct: 441 CNSQKERRE 449
>gi|21361759 myotubularin related protein 8 [Homo sapiens]
Length = 704
Score = 129 bits (323), Expect = 3e-29
Identities = 74/187 (39%), Positives = 106/187 (56%), Gaps = 5/187 (2%)
Query: 1335 NCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAV 1394
N F + I +++S +KL+ C T PT SE FL L S W + IM +
Sbjct: 265 NIRFRFMGIENIHVMRSSLQKLLEVCELKT-PTMSE--FLSGLESSGWLRHIKAIMDAGI 321
Query: 1395 VVSEVLE-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKF 1453
+++ ++ +SVLV +GWD TAQV S+ +L DPFYRT +G +L+EKEW+S GHKF
Sbjct: 322 FITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKF 381
Query: 1454 SQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFL 1513
SQR L+ +P+F QFLDC+ Q+ Q+P FEFN +L + H S +F FL
Sbjct: 382 SQRCG-HLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFL 440
Query: 1514 LDSDYER 1520
+ +R
Sbjct: 441 GNCQKDR 447
Score = 33.9 bits (76), Expect = 1.5
Identities = 16/57 (28%), Positives = 31/57 (54%)
Query: 1140 ITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLR 1196
IT +NR Y +C +YP +VVP++V ++ ++ R+PV+ + + + R
Sbjct: 148 ITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICR 204
>gi|19923424 myotubularin related protein 9 [Homo sapiens]
Length = 549
Score = 121 bits (303), Expect = 7e-27
Identities = 81/236 (34%), Positives = 127/236 (53%), Gaps = 17/236 (7%)
Query: 1349 VKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVL 1407
++ S KL+ AC T D ++ L+A S W + I+ A + ++ ++ G+S+L
Sbjct: 274 LQESLIKLVEACNDQTHNMDRWLSKLEA---SNWLTHIKEILTTACLAAQCIDREGASIL 330
Query: 1408 VCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQR--SSLTLNCQG 1465
+ EG D T QVTSL Q++ +P RT+ GF+ L+E+EWL GH F QR S N +
Sbjct: 331 IHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQ 390
Query: 1466 SGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGT 1525
APVFL FLDCV Q+ Q+P FEFN +L L H +++F TFL +++ ER +
Sbjct: 391 KWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCK--- 447
Query: 1526 LFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWD 1581
K +K + +W +++ + S F N L+ + + P+V SL W+
Sbjct: 448 ------LKLQQKTMSLWSWVNQPSELSK-FTNPLFEANNL-VIWPSVAPQSLPLWE 495
Score = 48.9 bits (115), Expect = 5e-05
Identities = 19/61 (31%), Positives = 41/61 (67%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+R++ N+ +++C SYP ++ VP+++ D +L +VA R PV+ + + ++G +++RS
Sbjct: 143 WRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRS 202
Query: 1198 G 1198
G
Sbjct: 203 G 203
>gi|134142348 myotubularin related protein 6 [Homo sapiens]
Length = 621
Score = 118 bits (296), Expect = 5e-26
Identities = 120/483 (24%), Positives = 198/483 (40%), Gaps = 109/483 (22%)
Query: 1101 SEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRITASNRMYSLCRSYPGLLVVP 1160
SE+ QL++ A +Y+R+G+ +++++ +NR Y +C +YP L VP
Sbjct: 119 SERLQGWQLIDLA--EEYKRMGVPN----------SHWQLSDANRDYKICETYPRELYVP 166
Query: 1161 QAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGFHGKGVVGLFKSQNSPQAAPT 1220
+ + ++ R PV+ + + + R + P
Sbjct: 167 RIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRC-------------------SQPL 207
Query: 1221 SSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAFALSPGVWASLRSSTRLISSP 1280
S S+ +E E LQA+ A V++ + + RP
Sbjct: 208 SGF-SARCLEDEHLLQAISKANPVNRYM---YVMDTRPKLNA------------------ 245
Query: 1281 TSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFGEKSQLRNFKVEFALNCEFVP 1340
+ R AGK + N N + +FV
Sbjct: 246 -----MANRAAGK----GYENEDNYSN--------------------------IRFQFVG 270
Query: 1341 VEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVL 1400
+E I +++S +KL+ + + F L S W + +M A+ +++ +
Sbjct: 271 IE--NIHVMRSSLQKLLEVNGTKGLSVND---FYSGLESSGWLRHIKAVMDAAIFLAKAI 325
Query: 1401 E-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSL 1459
+SVLV +GWD T+QV SL LL D +YRT++GF +L+EK+W+SFGHKFS+R
Sbjct: 326 TVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCG- 384
Query: 1460 TLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYE 1519
L+ +PVF QFL+CV + Q+P FEF+ +L + H S +F FL + E
Sbjct: 385 QLDGDPKEVSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKE 444
Query: 1520 RLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYS--PLEIEALKPNVNVSSL 1577
R E K +K +W + K+ + N LYS L+PN +
Sbjct: 445 REE---------LKLKEKTYSLWPFLLEDQKK---YLNPLYSSESHRFTVLEPNTVSFNF 492
Query: 1578 KKW 1580
K W
Sbjct: 493 KFW 495
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 110 bits (275), Expect = 1e-23
Identities = 106/396 (26%), Positives = 174/396 (43%), Gaps = 38/396 (9%)
Query: 54 WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPA 113
W + P F VLT + + Y + + FYE ++K+ + GL+ P
Sbjct: 8 WDPETKYPLPVFSTFVLTGSSAKKVYGAAIQFYEPYSRELLSEKQLMH-----LGLLTPV 62
Query: 114 E-------VFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLN-VSLESLIANLCACL-V 164
E + K + L+S + E FR L IY + V + + +E I++ +
Sbjct: 63 ERKMVSKSINTNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPF 122
Query: 165 PAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKV 224
P+ + L L D ++ P+ LP++G + + L LG +N +L VL E+K+
Sbjct: 123 PSPQRPRILVQLSVHDALILSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKI 182
Query: 225 LFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDV 284
L HS L+ A+ +++FP ++ PYIP+ P L VLS+P PFI+GV S + D+
Sbjct: 183 LLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRY-FDL 241
Query: 285 HE-LLDVIIADLDGGTIKIPE---CIHLSSLPEPLLHQTQSALSLILHPDL--------E 332
H+ DV+ DLD + + + ++ LP+ S L L+P L E
Sbjct: 242 HDPPQDVVCIDLDTNMLYVSDEKKNMNWKQLPKKPCKNLLSTLKK-LYPQLSSVHQKTQE 300
Query: 333 VADHAFPPPRTALSHSK---MLDKEVRAVFLRLFAQLFQGYRSCLQLI------RIHAEP 383
+ P S K L+ E++ FLR A + +GYR+ L+ I + A
Sbjct: 301 GSAIDMTPIEADFSWQKKMTQLEMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATAAD 360
Query: 384 VIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSE 419
+ F + FL R F T + F F+ E
Sbjct: 361 SL-FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEE 395
>gi|124028527 myotubularin related protein 10 [Homo sapiens]
Length = 777
Score = 110 bits (274), Expect = 2e-23
Identities = 77/255 (30%), Positives = 132/255 (51%), Gaps = 11/255 (4%)
Query: 1346 IRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLENGS- 1404
I++V+A+F KL + C+ ++E +L +L ++ W + ++ + + +LE+
Sbjct: 339 IQEVQAAFVKLKQLCVNEPFE-ETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHL 397
Query: 1405 SVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLTLNCQ 1464
SV++ EEG D++ V SLVQ++ DP++RT+ GFQ L++KEW+ G++F R + +
Sbjct: 398 SVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRSE 457
Query: 1465 GSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHG 1524
+P+FL FLD Q+ QYP FEF+ YL L + F TFL +S ++R++
Sbjct: 458 KE--SPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQS 515
Query: 1525 TLFD-----DKGEKHAKKGVCIWE-CIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLK 1578
T F G++ K +W+ + K +F N Y ++ N +V S K
Sbjct: 516 TEFAISKNIQLGDEKGLKFPSVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQ-NGSVKSFK 574
Query: 1579 KWDYYIEETLSTGPS 1593
+ TL PS
Sbjct: 575 RTKKSYSSTLRGMPS 589
Score = 40.8 bits (94), Expect = 0.012
Identities = 37/153 (24%), Positives = 61/153 (39%), Gaps = 3/153 (1%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+R+ + N Y + P +VVP ++ D L + + R+P+ CW +S +G+ L+R
Sbjct: 239 WRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHS-NGSALVRM 297
Query: 1198 GGFHGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVR 1257
K V+ K A T S S + + + L N V L V
Sbjct: 298 ALI--KDVLQQRKIDQRICNAITKSHPQRSDVYKSDLDKTLPNIQEVQAAFVKLKQLCVN 355
Query: 1258 PAFALSPGVWASLRSSTRLISSPTSFIDVGARL 1290
F + W S +TR + +F+ A L
Sbjct: 356 EPFEETEEKWLSSLENTRWLEYVRAFLKHSAEL 388
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 105 bits (261), Expect = 5e-22
Identities = 93/366 (25%), Positives = 159/366 (43%), Gaps = 68/366 (18%)
Query: 3 RLADYFIVVGYDHE---KPG--SGEGL----------GKIIQRFPQK-DWDDTPFPQ-GI 45
R A YF++ G D + +P +GE K++ +PQ +W+ PF Q +
Sbjct: 20 RFAHYFVLCGIDADSGLEPDELAGENFDQSPLRRTFKSKVLAHYPQNIEWN--PFDQDAV 77
Query: 46 ELFCQPGG--WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQ---------- 93
+ C P G ++ + K P F ++T D R Y LTFYE + Q
Sbjct: 78 NMLCMPKGLSFRTQTDNKDPQFHSFIITREDGSRTYGFVLTFYEEVTSKQICTAMQTLYQ 137
Query: 94 ---------------------------GTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSR 126
G ++ + S I ++ KS+ L++
Sbjct: 138 MHNAEHYSSVYASSSCSMDSLASSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITP 197
Query: 127 LYYPEIFRACLGLIYTVYVDSLN--VSLESLIAN-LCACLVPAAGGSQKLFSLGAGDRQL 183
L + + + L +Y + LES I N L +P G S K + G + +
Sbjct: 198 LPFMQACKKFLIQLYKAVTSQQPPPLPLESYIHNILYEVPLPPPGRSLKFY--GVYEPVI 255
Query: 184 IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALES 243
Q P LP++ + F+ LG++N++ +F VL E ++L +S +QRL + +
Sbjct: 256 CQRPGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITT 315
Query: 244 LMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHEL-----LDVIIADLDGG 298
L+FP ++ + Y+PILPA LL L +P P+++G+ S TD +L ++ D+D
Sbjct: 316 LLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
Query: 299 TIKIPE 304
I++PE
Sbjct: 376 FIELPE 381
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 101 bits (252), Expect = 6e-21
Identities = 85/325 (26%), Positives = 149/325 (45%), Gaps = 50/325 (15%)
Query: 26 KIIQRFPQK-DWDDTPFPQ-GIELFCQPGG--WQLSRERKQPTFFVVVLTDIDSDRHYCS 81
K++ R+P+ +W+ PF Q + + C P G ++ + ++P F ++T D R +
Sbjct: 76 KVLARYPENVEWN--PFDQDAVGMLCMPKGLAFKTQADPREPQFHAFIITREDGSRTFGF 133
Query: 82 CLTFYE-------------------AEIN-LQGTKKEEIEGEAKVSGLIQPAE------- 114
LTFYE AE + L ++ + + G P
Sbjct: 134 ALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDGEDTPVTKLQRFNS 193
Query: 115 -------VFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLN--VSLESLIAN-LCACLV 164
++ K + L++ + + + R+ L ++ + LES I N L +
Sbjct: 194 YDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIYNVLYEVPL 253
Query: 165 PAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKV 224
P G S K FS G + Q P + LP+ V +F+ LG++NV LF L E ++
Sbjct: 254 PPPGRSLK-FS-GVYGPIICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEFQI 311
Query: 225 LFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHS-----V 279
L +S +QRL + +LMFP ++ + Y+PILPA LL L +P P+++G+HS
Sbjct: 312 LLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDR 371
Query: 280 FKTDVHELLDVIIADLDGGTIKIPE 304
K ++ + ++ D+D I++PE
Sbjct: 372 SKLELPQEANLCFVDIDNHFIELPE 396
>gi|94721263 myotubularin related protein 12 [Homo sapiens]
Length = 747
Score = 100 bits (248), Expect = 2e-20
Identities = 76/250 (30%), Positives = 120/250 (48%), Gaps = 8/250 (3%)
Query: 1341 VEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVL 1400
+ EI+ + FK+L ST D+++ + L S W + R ++ A+ ++E +
Sbjct: 322 LSLQEIQTAYSKFKQLF-LIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECM 380
Query: 1401 E-NGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSL 1459
E +VL+ E D+ ++SLVQL+ DP RT GFQ L++KEW+ GH F R +
Sbjct: 381 EAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCN- 439
Query: 1460 TLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYE 1519
L PVFL FLDCV Q+ +Q+P FEF YL L+ F TF +S ++
Sbjct: 440 HLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQ 499
Query: 1520 RLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKK 1579
+ T +G+ K + + D + P L +PL +E KP ++ K
Sbjct: 500 K---DTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPLYVE--KPKLDKGQRKG 554
Query: 1580 WDYYIEETLS 1589
+ + LS
Sbjct: 555 MRFKHQRQLS 564
>gi|224994251 myotubularin related protein 11 isoform a [Homo sapiens]
Length = 709
Score = 92.0 bits (227), Expect = 5e-18
Identities = 62/180 (34%), Positives = 97/180 (53%), Gaps = 6/180 (3%)
Query: 1342 EFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLE 1401
E + V+ + +L C+P + + +E +L AL + W + ++ A +S ++
Sbjct: 308 ELPSLADVQLAHLRLRALCLPDS--SVAEDKWLSALEGTRWLDYVRACLRKASDISVLVT 365
Query: 1402 NGSSVLVCLEEG-WDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLT 1460
+ ++ E G D+ ++SLVQLLS P RTL GFQ LV++EW++ GH F R T
Sbjct: 366 SRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGT 425
Query: 1461 LNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYER 1520
S APVFL FLDCV Q+ Q+P +FEF+ ++L L TFL ++ +ER
Sbjct: 426 ---GASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 482
Score = 35.0 bits (79), Expect = 0.68
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+R++ N + + S P VP + DS + R + R P + W + G+ LLR
Sbjct: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRC 272
Query: 1198 GGFH 1201
GGF+
Sbjct: 273 GGFY 276
>gi|89111941 myotubularin related protein 11 isoform b [Homo sapiens]
Length = 640
Score = 92.0 bits (227), Expect = 5e-18
Identities = 62/180 (34%), Positives = 97/180 (53%), Gaps = 6/180 (3%)
Query: 1342 EFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLE 1401
E + V+ + +L C+P + + +E +L AL + W + ++ A +S ++
Sbjct: 236 ELPSLADVQLAHLRLRALCLPDS--SVAEDKWLSALEGTRWLDYVRACLRKASDISVLVT 293
Query: 1402 NGSSVLVCLEEG-WDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQRSSLT 1460
+ ++ E G D+ ++SLVQLLS P RTL GFQ LV++EW++ GH F R T
Sbjct: 294 SRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRLGGT 353
Query: 1461 LNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYER 1520
S APVFL FLDCV Q+ Q+P +FEF+ ++L L TFL ++ +ER
Sbjct: 354 ---GASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNTPWER 410
Score = 35.0 bits (79), Expect = 0.68
Identities = 19/64 (29%), Positives = 31/64 (48%), Gaps = 1/64 (1%)
Query: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
+R++ N + + S P VP + DS + R + R P + W + G+ LLR
Sbjct: 142 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHP-GGSDLLRC 200
Query: 1198 GGFH 1201
GGF+
Sbjct: 201 GGFY 204
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 84.7 bits (208), Expect = 7e-16
Identities = 97/410 (23%), Positives = 179/410 (43%), Gaps = 47/410 (11%)
Query: 37 DDTPFPQGIELF-----CQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFY----E 87
+D P G++L C PGG ++ E K+ +VLTD+ +R Y +Y +
Sbjct: 29 EDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHD 88
Query: 88 AEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDS 147
G E G F P ++ +VSR Y + CL + +
Sbjct: 89 EYCFYNGKTHRECPG------------CFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPC 136
Query: 148 LNVSLESLIANLCACLV----PAAGGSQKLFSLGAGDRQLIQTPLHD-SLPITGTSVALL 202
+ ++S I + A L P G +F++ + Q++ D PI + L
Sbjct: 137 KDFEVDSHIKDFAAKLSLIPSPPPGPLHLVFNMKS--LQIVLPARADPESPILDLDLHLP 194
Query: 203 FQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQL 262
+ VL + +LTE +++F S+ + L+ + ++PL++ +P++PIL Q+
Sbjct: 195 LLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQM 254
Query: 263 LEVLSSPTPFIIGVHSVFKTDVHELLD-VIIADLDGGTIKIPECIHLS-SLPE-PLL-HQ 318
L+ + +PT F++G H +V + D +++ ++D G+I + + +P+ PLL Q
Sbjct: 255 LDFVMAPTSFLMGCHLDHFEEVSKEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQ 314
Query: 319 T--QSALSLILHPDLEVADHAFPPP--RTALSH----SKMLDKEVRAVFLRLFAQLFQGY 370
T Q SL LH +L A H + +H + L+ +++ L+L +F+
Sbjct: 315 TFIQRVQSLQLHHELHAA-HLLSSTDLKEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDV 373
Query: 371 RSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER 420
++ L + V F+ FL R ++ F +VL F F+ R
Sbjct: 374 KNHLN----YEHRV--FNSEEFLKTRAPGDHQFYKQVLDTYMFHSFLKAR 417
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 82.4 bits (202), Expect = 4e-15
Identities = 90/398 (22%), Positives = 154/398 (38%), Gaps = 64/398 (16%)
Query: 27 IIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFY 86
++ +FP+ D+ D Q + FC P + + + F VLTDI+S + + C
Sbjct: 31 VLWKFPE-DFGDQEILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFC---- 85
Query: 87 EAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVD 146
+ GT L ++S L + E++ L +
Sbjct: 86 --RLTSGGTI-----------------------CLCILSYLPWFEVYYKLLNTLADYLAK 120
Query: 147 SLNVSLESLIANLCACLVPAAGGSQKLFSLGAGDRQLIQTPLHDSLPITGTSVALL--FQ 204
L L + +L VP A L P LP S L F
Sbjct: 121 ELENDLNETLRSLYNHPVPKANTPVNL-----SVHSYFIAPDVTGLPTIPESRNLTEYFV 175
Query: 205 QLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLE 264
+ + N+L L+ ++L E +++ S+ L+ +L++P+ + + YIP+LP LL+
Sbjct: 176 AVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLD 235
Query: 265 VLSSPTPFIIGVHS--VFKTDVHELLDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSA 322
+P P++IG+HS + + L DV++ ++D T++ P L++LP ++ ++
Sbjct: 236 YCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESP-FSDLNNLPSDVVSALKNK 294
Query: 323 LSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAE 382
L S V FLR A LF YR L R
Sbjct: 295 LK---------------------KQSTATGDGVARAFLRAQAALFGSYRDAL---RYKPG 330
Query: 383 PVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER 420
I F + +F+ R V FL ++ F F+ R
Sbjct: 331 EPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGR 368
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 82.0 bits (201), Expect = 5e-15
Identities = 112/442 (25%), Positives = 181/442 (40%), Gaps = 73/442 (16%)
Query: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIEL---------FCQPGG 53
+L + F+VV +KP + ++IQ+FP KD D + Q ++ FC P
Sbjct: 432 QLFELFVVVSLQ-KKPSGISYIPQVIQQFPGKD--DHGYKQSKDMEERLKVIPKFCFPDS 488
Query: 54 --WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQ 111
W + E K TF V LT D R + C KK G+ K
Sbjct: 489 KDWMPTSELKSETFSFV-LTGEDGSRWFGYC-------------KKLLPVGKGKR----- 529
Query: 112 PAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLES-------LIANLCACLV 164
P+ +VSRL C L ++ +D + E + ++
Sbjct: 530 -----LPEVYCMVSRL-------GCFNL-FSKILDEVEKRREMSPALVYPFMRSVMEAPF 576
Query: 165 PAAGGS--QKLFSLGAGDRQL-IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTE 221
PA G + K + GAGD + + PL L LF+ L + +++ + ++L E
Sbjct: 577 PAPGRTITVKSYLPGAGDESIELCRPLDSRLE--HVDFKCLFKCLSVCHLIRVCASLLLE 634
Query: 222 NKVLFHSASFQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFK 281
+V+F + S LS A+ + ++P + + YIP+LPA +++++ SPTPF+IG+ S
Sbjct: 635 RRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSL 694
Query: 282 TDVHEL--LDVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFP 339
+ +L +V+I DL +S E L + Q+AL IL E+
Sbjct: 695 PQLQDLPIEEVLIVDLCADKF----LQEVSDEDEILPPKLQAALMQILEERNEILTQ--- 747
Query: 340 PPRTALSHSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAF-LGQRGL 398
S L+ V F+R F +L G+ S + E V F + F
Sbjct: 748 --EQNFSQDVTLNSLVSEAFVRFFVELV-GHYSLNMTVTERGERV--FQREPFRKSHTSR 802
Query: 399 VENDFLTKVLSGMAFAGFVSER 420
FL + FAGF+ +R
Sbjct: 803 SVRHFLDLFMETQMFAGFIQDR 824
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 79.0 bits (193), Expect = 4e-14
Identities = 89/413 (21%), Positives = 162/413 (39%), Gaps = 74/413 (17%)
Query: 27 IIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFY 86
++ +FP+ D+ D Q + FC P + + + F VLTDI+S + + C
Sbjct: 31 VLWKFPE-DFGDQEILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFC---- 85
Query: 87 EAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVD 146
+ GT L ++S L + E++ L +
Sbjct: 86 --RLTSGGTI-----------------------CLCILSYLPWFEVYYKLLNTLADYLAK 120
Query: 147 SLNVSLESLIANLCACLVPAAGG------SQKLF----SLGAGDRQLIQTPLHDSLPITG 196
L L + +L VP A +Q++F + L+ + +TG
Sbjct: 121 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTG 180
Query: 197 T-------SVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALESLMFPLK 249
++ F + + N+L L+ ++L E +++ S+ L+ +L++P+
Sbjct: 181 LPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMY 240
Query: 250 YSYPYIPILPAQLLEVLSSPTPFIIGVHS--VFKTDVHELLDVIIADLDGGTIKIPECIH 307
+ + YIP+LP LL+ +P P++IG+HS + + L DV++ ++D T++ P
Sbjct: 241 WQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESP-FSD 299
Query: 308 LSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLFAQLF 367
L++LP ++ ++ L S V FLR A LF
Sbjct: 300 LNNLPSDVVSALKNKLK---------------------KQSTATGDGVARAFLRAQAALF 338
Query: 368 QGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER 420
YR L R I F + +F+ R V FL ++ F F+ R
Sbjct: 339 GSYRDAL---RYKPGEPITFCEESFVKHRSSVMKQFLETAINLQLFKQFIDGR 388
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 77.0 bits (188), Expect = 2e-13
Identities = 107/434 (24%), Positives = 175/434 (40%), Gaps = 50/434 (11%)
Query: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQ-------GIELFCQPGG-- 53
+L +YF+VV H+K + ++ Q+FP K F + I FC P
Sbjct: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
Query: 54 WQLSRERKQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPA 113
W ++ TF V LT D R + C L G K + +
Sbjct: 622 WVPVQQFTSETFSFV-LTGEDGSRRFGYCRRL------LPGGKGKRL------------- 661
Query: 114 EVFAPKSLVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGS--Q 171
P+ +VSRL +F L + S + ++ L+ ++ PA G +
Sbjct: 662 ----PEVYCIVSRLGCFSLFSRILDEVEKRRGISPAL-VQPLMRSVMEAPFPALGKTILV 716
Query: 172 KLFSLGAGDRQL-IQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSAS 230
K F G+G + + PL L LF L +++++ +F ++L E +V+F +
Sbjct: 717 KNFLPGSGTEVIELCRPLDSRLE--HVDFESLFSSLSVRHLVCVFASLLLERRVIFIADK 774
Query: 231 FQRLSDACRALESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHE--LL 288
LS C A+ +L++P + + YIP+LP +++++ SPTPF+IG+ S + E L
Sbjct: 775 LSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLE 834
Query: 289 DVIIADLDGGTIKIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTAL--S 346
+V++ DL S LP L Q AL IL E+A P
Sbjct: 835 EVLVVDLVNSRFLRQMDDEDSILPRKL----QVALEHILEQRNELACEQDEGPLDGRHGP 890
Query: 347 HSKMLDKEVRAVFLRLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTK 406
S L++ V F+R F ++ Y L + + + L FL
Sbjct: 891 ESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSKSL--RHFLEV 948
Query: 407 VLSGMAFAGFVSER 420
+ F GF+ ER
Sbjct: 949 FMETQMFRGFIQER 962
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,367,757
Number of Sequences: 37866
Number of extensions: 3297233
Number of successful extensions: 8562
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 82
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 8234
Number of HSP's gapped (non-prelim): 278
length of query: 1849
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1732
effective length of database: 13,817,196
effective search space: 23931383472
effective search space used: 23931383472
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.