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Search of human proteins with 29171755
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]
(1257 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens] 2447 0.0
gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap... 1561 0.0
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa... 1540 0.0
gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens] 1345 0.0
gi|55769554 protein tyrosine phosphatase, receptor type, f polyp... 892 0.0
gi|157837985 kazrin isoform E [Homo sapiens] 177 4e-44
gi|29294627 PTPRF interacting protein binding protein 1 isoform ... 155 2e-37
gi|170784854 PTPRF interacting protein, binding protein 2 (lipri... 149 1e-35
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 110 1e-23
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 103 1e-21
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 102 2e-21
gi|31982906 cingulin-like 1 [Homo sapiens] 102 2e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 100 7e-21
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 100 1e-20
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 99 3e-20
gi|16262452 cingulin [Homo sapiens] 99 3e-20
gi|38044112 restin isoform b [Homo sapiens] 96 2e-19
gi|4506751 restin isoform a [Homo sapiens] 96 2e-19
gi|42794779 myosin 18A isoform b [Homo sapiens] 96 2e-19
gi|28416946 myosin 18A isoform a [Homo sapiens] 96 2e-19
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 96 2e-19
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 96 2e-19
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 96 2e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 96 3e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 95 4e-19
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 95 4e-19
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 95 5e-19
gi|110347443 TATA element modulatory factor 1 [Homo sapiens] 94 1e-18
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 94 1e-18
gi|148746195 trichohyalin [Homo sapiens] 93 2e-18
>gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]
Length = 1257
Score = 2447 bits (6342), Expect = 0.0
Identities = 1257/1257 (100%), Positives = 1257/1257 (100%)
Query: 1 MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQ 60
MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQ
Sbjct: 1 MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQ 60
Query: 61 QRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEK 120
QRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEK
Sbjct: 61 QRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEK 120
Query: 121 EEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSL 180
EEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSL
Sbjct: 121 EEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSL 180
Query: 181 FEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE 240
FEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE
Sbjct: 181 FEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE 240
Query: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE 300
HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE
Sbjct: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE 300
Query: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM 360
VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM
Sbjct: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM 360
Query: 361 NDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAAL 420
NDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAAL
Sbjct: 361 NDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAAL 420
Query: 421 TKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL 480
TKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL
Sbjct: 421 TKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL 480
Query: 481 QLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLI 540
QLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLI
Sbjct: 481 QLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLI 540
Query: 541 EPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEW 600
EPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEW
Sbjct: 541 EPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEW 600
Query: 601 NRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAI 660
NRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAI
Sbjct: 601 NRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAI 660
Query: 661 NKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPS 720
NKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPS
Sbjct: 661 NKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPS 720
Query: 721 GHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPR 780
GHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPR
Sbjct: 721 GHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPR 780
Query: 781 ALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGK 840
ALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGK
Sbjct: 781 ALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGK 840
Query: 841 KEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDG 900
KEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDG
Sbjct: 841 KEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDG 900
Query: 901 PTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQE 960
PTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQE
Sbjct: 901 PTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQE 960
Query: 961 MVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMN 1020
MVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMN
Sbjct: 961 MVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMN 1020
Query: 1021 HEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMC 1080
HEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMC
Sbjct: 1021 HEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMC 1080
Query: 1081 LKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIA 1140
LKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIA
Sbjct: 1081 LKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIA 1140
Query: 1141 LDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQ 1200
LDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQ
Sbjct: 1141 LDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQ 1200
Query: 1201 FPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC 1257
FPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC
Sbjct: 1201 FPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC 1257
>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sapiens]
Length = 1202
Score = 1561 bits (4041), Expect = 0.0
Identities = 851/1285 (66%), Positives = 1003/1285 (78%), Gaps = 111/1285 (8%)
Query: 1 MMCEVMPTINE-DTPMSQRGSQSSGS----DSDSHFEQLMVNMLDERDRLLDTLRETQES 55
MMCEVMPTI+E + P G SGS D+DSHFEQLMV+ML+ERDRLLDTLRETQE+
Sbjct: 1 MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
Query: 56 LSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACRE 115
L+L Q +L +V ++RDSLQRQLN+ALPQ EFAALTKELN CRE
Sbjct: 61 LALTQGKLHEVGHERDSLQRQLNTALPQ------------------EFAALTKELNVCRE 102
Query: 116 QLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLK 175
QLLE+EEEI+ELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP+GVSSEVEVLK
Sbjct: 103 QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLK 162
Query: 176 ALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEG 235
ALKSLFEHHKALDEKVRERLRV+LER S LEEEL A ++E++ L+EQN +K ++G
Sbjct: 163 ALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQN---NQKKTLTDG 219
Query: 236 STESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALS 295
+ H + P KR S+GS+ ++ ++++ELQE++ KQ+ E +QMKERLA+LS
Sbjct: 220 VLDINHEQENTPSTS--GKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLS 277
Query: 296 SRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQREST 355
S V E+E++ +TARKDLIK+EEMNTK QRD+REAMAQKEDMEERITTLEKRYL+AQRE+T
Sbjct: 278 SHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT 337
Query: 356 SIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQ 415
S+HD+NDKLENE+ANK+++ RQ E+KNRQLQERLELAEQKLQQT+RKAETLPEVEAELAQ
Sbjct: 338 SVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQ 397
Query: 416 RIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTE 475
R+AAL+KAEERHGNIEER+R +E QLEEKNQELQRARQREKMNEEHNKRLSDTVD+LL+E
Sbjct: 398 RVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSE 457
Query: 476 SNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMR 535
SNERLQLHLKERMAALE+KN L++E E+ +K LEE+ HDK++L IE LR+ELD +++R
Sbjct: 458 SNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLR 517
Query: 536 TGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSD-YRTTKVIRRPRRGRMGVRRDEP-KVK 593
SL R HL + + R+ + D +D Y T+ V+RRP++GR+ RDEP KV+
Sbjct: 518 GASLHH---GRPHLGSVPDFRF---PMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQ 571
Query: 594 SLGDHEWNRTQQIGVLS--SHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAM 651
+L + +W R QQ VL+ + FESD ++SD +DDR+T+ SS+DLLSPSG +DA TLAM
Sbjct: 572 TLNEQDWERAQQASVLANVAQAFESDADVSD-GEDDRDTLLSSVDLLSPSGQADAHTLAM 630
Query: 652 MLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTAS 711
MLQEQLDAINKEIRLIQEEKE+TE RAEEIE+RV S SL+ NL R +SI AS
Sbjct: 631 MLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLD--NLGRFRSMSSI-PPYPAS 687
Query: 712 SLASSSPP-SGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIK 770
SLASSSPP SG STP+ P SPARE+DR+GVMTL R E+ R+DK TIK
Sbjct: 688 SLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSR----------EEVRDDKTTIK 737
Query: 771 CETSPPPTPRALRM-------THTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHK 823
CETSPP +PRALR+ HT+ D R+S P S S+NSSQDSLHK
Sbjct: 738 CETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVS-NPSSSNSSQDSLHK 796
Query: 824 APKKKGIKSSIGRLFGKKEKARLGQL-------RGFMETEAAAQESLGLGKLGTQAEKDR 876
APKKKGIKSSIGRLFGKKEK R GQ G ET+ ++Q++LGL KLG QAEK+R
Sbjct: 797 APKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNR 856
Query: 877 RLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSD 936
+L+KKHELLEEARR+GLPFAQWDGPTVV WLELW+GMPAWYVAACRANVKSGAIMSALSD
Sbjct: 857 KLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSD 916
Query: 937 TEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKT 996
TEIQREIGISNPLHRLKLRLAIQE++SLTSPSAPPTSRT
Sbjct: 917 TEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRT--------------------- 955
Query: 997 KESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK 1056
TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK
Sbjct: 956 ----------------TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK 999
Query: 1057 KDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRW 1116
KDLR LKMVDSFHR S Q GIMCL+RLNYDRKELER+RE SQ EIKDVLVWSNDRVIRW
Sbjct: 1000 KDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRW 1059
Query: 1117 IQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLA 1176
I +IGL+EYANN++ESGVHG+L+ALDE FD+S+LALLLQIPTQNTQAR +LERE+NNLL
Sbjct: 1060 ILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLV 1119
Query: 1177 LGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTT----SGQS 1232
+GT+RR DE DDK+FRR +WR++F P+++ G++ GS+ETLPA FR+T++ S Q
Sbjct: 1120 MGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLA--AGSAETLPANFRVTSSMSSPSMQP 1177
Query: 1233 RKMTTDVASSRLQRLDNSTVRTYSC 1257
+KM D S QRLD++TVRTYSC
Sbjct: 1178 KKMQMDGNVSGTQRLDSATVRTYSC 1202
>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
sapiens]
Length = 1185
Score = 1540 bits (3986), Expect = 0.0
Identities = 839/1266 (66%), Positives = 989/1266 (78%), Gaps = 111/1266 (8%)
Query: 1 MMCEVMPTINE-DTPMSQRGSQSSGS----DSDSHFEQLMVNMLDERDRLLDTLRETQES 55
MMCEVMPTI+E + P G SGS D+DSHFEQLMV+ML+ERDRLLDTLRETQE+
Sbjct: 1 MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
Query: 56 LSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACRE 115
L+L Q +L +V ++RDSLQRQLN+ALPQ EFAALTKELN CRE
Sbjct: 61 LALTQGKLHEVGHERDSLQRQLNTALPQ------------------EFAALTKELNVCRE 102
Query: 116 QLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLK 175
QLLE+EEEI+ELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP+GVSSEVEVLK
Sbjct: 103 QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLK 162
Query: 176 ALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEG 235
ALKSLFEHHKALDEKVRERLRV+LER S LEEEL A ++E++ L+EQN +K ++G
Sbjct: 163 ALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQN---NQKKTLTDG 219
Query: 236 STESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALS 295
+ H + P KR S+GS+ ++ ++++ELQE++ KQ+ E +QMKERLA+LS
Sbjct: 220 VLDINHEQENTPSTS--GKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLS 277
Query: 296 SRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQREST 355
S V E+E++ +TARKDLIK+EEMNTK QRD+REAMAQKEDMEERITTLEKRYL+AQRE+T
Sbjct: 278 SHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT 337
Query: 356 SIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQ 415
S+HD+NDKLENE+ANK+++ RQ E+KNRQLQERLELAEQKLQQT+RKAETLPEVEAELAQ
Sbjct: 338 SVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQ 397
Query: 416 RIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTE 475
R+AAL+KAEERHGNIEER+R +E QLEEKNQELQRARQREKMNEEHNKRLSDTVD+LL+E
Sbjct: 398 RVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSE 457
Query: 476 SNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMR 535
SNERLQLHLKERMAALE+KN L++E E+ +K LEE+ HDK++L IE LR+ELD +++R
Sbjct: 458 SNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLR 517
Query: 536 TGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSD-YRTTKVIRRPRRGRMGVRRDEP-KVK 593
SL R HL + + R+ + D +D Y T+ V+RRP++GR+ RDEP KV+
Sbjct: 518 GASLHH---GRPHLGSVPDFRF---PMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQ 571
Query: 594 SLGDHEWNRTQQIGVLS--SHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAM 651
+L + +W R QQ VL+ + FESD ++SD +DDR+T+ SS+DLLSPSG +DA TLAM
Sbjct: 572 TLNEQDWERAQQASVLANVAQAFESDADVSD-GEDDRDTLLSSVDLLSPSGQADAHTLAM 630
Query: 652 MLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTAS 711
MLQEQLDAINKEIRLIQEEKE+TE RAEEIE+RV S SL+ NL R +SI AS
Sbjct: 631 MLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLD--NLGRFRSMSSI-PPYPAS 687
Query: 712 SLASSSPP-SGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIK 770
SLASSSPP SG STP+ P SPARE+DR+GVMTL R E+ R+DK TIK
Sbjct: 688 SLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSR----------EEVRDDKTTIK 737
Query: 771 CETSPPPTPRALRM-------THTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHK 823
CETSPP +PRALR+ HT+ D R+S P S S+NSSQDSLHK
Sbjct: 738 CETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVS-NPSSSNSSQDSLHK 796
Query: 824 APKKKGIKSSIGRLFGKKEKARLGQL-------RGFMETEAAAQESLGLGKLGTQAEKDR 876
APKKKGIKSSIGRLFGKKEK R GQ G ET+ ++Q++LGL KLG QAEK+R
Sbjct: 797 APKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNR 856
Query: 877 RLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSD 936
+L+KKHELLEEARR+GLPFAQWDGPTVV WLELW+GMPAWYVAACRANVKSGAIMSALSD
Sbjct: 857 KLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSD 916
Query: 937 TEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKT 996
TEIQREIGISNPLHRLKLRLAIQE++SLTSPSAPPTSRT
Sbjct: 917 TEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRT--------------------- 955
Query: 997 KESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK 1056
TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK
Sbjct: 956 ----------------TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK 999
Query: 1057 KDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRW 1116
KDLR LKMVDSFHR S Q GIMCL+RLNYDRKELER+RE SQ EIKDVLVWSNDRVIRW
Sbjct: 1000 KDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRW 1059
Query: 1117 IQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLA 1176
I +IGL+EYANN++ESGVHG+L+ALDE FD+S+LALLLQIPTQNTQAR +LERE+NNLL
Sbjct: 1060 ILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLV 1119
Query: 1177 LGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTT----SGQS 1232
+GT+RR DE DDK+FRR +WR++F P+++ G++ GS+ETLPA FR+T++ S Q
Sbjct: 1120 MGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLA--AGSAETLPANFRVTSSMSSPSMQP 1177
Query: 1233 RKMTTD 1238
+KM D
Sbjct: 1178 KKMQMD 1183
>gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]
Length = 1194
Score = 1345 bits (3480), Expect = 0.0
Identities = 753/1279 (58%), Positives = 924/1279 (72%), Gaps = 107/1279 (8%)
Query: 1 MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQ 60
MMCEVMPTI+ED +RGS ++ E+LMV ML ER+RLL+TLRE Q+ L+ AQ
Sbjct: 1 MMCEVMPTISED---GRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQ 57
Query: 61 QRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEK 120
RL+++ +++DSLQRQL+ ALPQ EFAALTKELN CREQLLE+
Sbjct: 58 LRLRELGHEKDSLQRQLSIALPQ------------------EFAALTKELNLCREQLLER 99
Query: 121 EEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSL 180
EEEI+ELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP GVSSEVEVLKALKSL
Sbjct: 100 EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSL 159
Query: 181 FEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE 240
FEHHKALDEKVRERLR++LERV+ LEEEL +NQE + LREQ + R+ + E
Sbjct: 160 FEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQ---LSRRRSGLE------ 210
Query: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE 300
EPG+ + L+NG D + EL+E LE+Q E+ Q++ERLA L ++ +
Sbjct: 211 -----EPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQ 265
Query: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM 360
+E+E TA ++L K EE N+K QRD++EA+AQ+EDMEERITTLEKRYLSAQRE+TS+HD
Sbjct: 266 LEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDA 325
Query: 361 NDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAAL 420
NDKLENELA+KE++ RQ EEK+RQL E L+ A+QKLQQT++KAETLPE+EA+LAQR+AAL
Sbjct: 326 NDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAAL 385
Query: 421 TKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL 480
KAEERHGN EER+R LE QLEEKNQELQRARQREKMN++HNKRLS+TVD+LL+ESNERL
Sbjct: 386 NKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERL 445
Query: 481 QLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLI 540
QLHLKERM ALEEKN L +E +K +E L +KE+L E+E+++ E+DQL+ R S
Sbjct: 446 QLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSY 505
Query: 541 EPTIPRTHLDTSAELRYSVGSLVDSQS--DYRTTKVIRRPRRGRMGVRRDEPKVKSLGDH 598
++P + L ELRYS + S + D R +RGR ++EP
Sbjct: 506 SRSLPGSAL----ELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEP------SK 555
Query: 599 EWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLD 658
+W R+ G + PF E+ D+++ E +F + +LLSPSG +D QTLA+MLQEQL+
Sbjct: 556 DWERSAPAGSIPP-PFPG--ELDGSDEEEAEGMFGA-ELLSPSGQADVQTLAIMLQEQLE 611
Query: 659 AINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSP 718
AINKEI+LIQEEKE+TE RAEE+E+RV+S L+ +L R S+ S+T S+LAS SP
Sbjct: 612 AINKEIKLIQEEKETTEQRAEELESRVSSSGLD--SLGRYRSSCSLPPSLTTSTLASPSP 669
Query: 719 P-SGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDG--REDKATIKCETSP 775
P SGHSTP+L P SPARE +D H K EE G R + I +T P
Sbjct: 670 PSSGHSTPRLAPPSPARE---------GTDKANHVPK----EEAGAPRGEGPAIPGDT-P 715
Query: 776 PPTPRALRMTHTLPSSYHNDARSSLSVSLEPESLGLG----SANSSQDSLHKAPKKKGIK 831
PPTPR+ R+ R + +++L+ SL G + + DSLHKAPKKK IK
Sbjct: 716 PPTPRSARL-----------ERMTQALALQAGSLEDGGPPRGSEGTPDSLHKAPKKKSIK 764
Query: 832 SSIGRLFGKKEKARLG-------QLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHEL 884
SSIGRLFGKKEK R+G L G E A + LGL KL +KDRR K+KHEL
Sbjct: 765 SSIGRLFGKKEKGRMGPPGRDSSSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHEL 824
Query: 885 LEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIG 944
LEEA R+GLPFA WDGPTVV+WLELW+GMPAWYVAACRANVKSGAIM+ LSDTEIQREIG
Sbjct: 825 LEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIG 884
Query: 945 ISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSW 1004
ISNPLHRLKLRLAIQEMVSLTSPSAP +SRT +GNVW+THEEME+L A K E++E SW
Sbjct: 885 ISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTK-PETKEISW 943
Query: 1005 AQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLK 1064
Q LAYGDMNHEW+GN+WLPSLGLPQYRSYFME LVDARMLDHL KK+LR LK
Sbjct: 944 E------QILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLK 997
Query: 1065 MVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLRE 1124
MVDSFHR SL YGIMCLKRLNYDRK+LERRRE SQ +I+DV+VWSN+RV+ W+ +GL+E
Sbjct: 998 MVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKE 1057
Query: 1125 YANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLD 1184
+A N+ ESGVHG+L+ALDE FDYS LALLLQIPTQN QARQ+LE+E++NL++LGT+RRLD
Sbjct: 1058 FATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLD 1117
Query: 1185 ESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTTSGQS------RKMTTD 1238
E K+F R +WR+ F +++ G++ P S+E LP FR RK+ +
Sbjct: 1118 EDSAKSFSRSPSWRKMFREKDLRGVT--PDSAEMLPPNFRSAAAGALGSPGLPLRKLQPE 1175
Query: 1239 VASSRLQRLDNSTVRTYSC 1257
+S R D +VRTYSC
Sbjct: 1176 GQTSGSSRADGVSVRTYSC 1194
>gi|55769554 protein tyrosine phosphatase, receptor type, f
polypeptide (PTPRF), interacting protein (liprin), alpha
4 [Homo sapiens]
Length = 701
Score = 892 bits (2306), Expect = 0.0
Identities = 465/660 (70%), Positives = 537/660 (81%), Gaps = 27/660 (4%)
Query: 584 GVRRDEPKVKSLGDHEWNRTQQIGVLS---SHPFESDTEMSDIDDDDRETIFSSMDLLSP 640
GV R ++ +W + G+L+ F+SD E+SD+D+D+ + S D++SP
Sbjct: 20 GVHRRYSALREESAKDWETSPLPGMLAPAAGPAFDSDPEISDVDEDEPGGLVGSADVVSP 79
Query: 641 SGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHP 700
SGHSDAQTLAMMLQEQLDAIN+EIR+IQEEKESTELRAEEIE RV S S+E LNL ++
Sbjct: 80 SGHSDAQTLAMMLQEQLDAINEEIRMIQEEKESTELRAEEIETRVTSGSMEALNLKQLRK 139
Query: 701 GTSITASVTASSLASSSPP-SGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIA--V 757
SI S+TA SLAS+SPP SG STPKLT RS A+++DRMGVMTLPSDLRKHRRK+ V
Sbjct: 140 RGSIPTSLTALSLASASPPLSGRSTPKLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPV 199
Query: 758 VEEDGREDKATIKCETSPPPTPRALRMTHT-LPSSYHNDARSSLSVSLEPESLGLGSANS 816
E+ REDKATIKCETSPP +PR LR+ P+ + +S+L E + S+NS
Sbjct: 200 SREENREDKATIKCETSPPSSPRTLRLEKLGHPALSQEEGKSAL----EDQGSNPSSSNS 255
Query: 817 SQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRG--------FMETEAAAQESLGLGKL 868
SQDSLHK K+KGIKSSIGRLFGKKEK RL QL ++E + QE + KL
Sbjct: 256 SQDSLHKGAKRKGIKSSIGRLFGKKEKGRLIQLSRDGATGHVLLTDSEFSMQEPMVPAKL 315
Query: 869 GTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSG 928
GTQAEKDRRLKKKH+LLE+ARRKG+PFAQWDGPTVV+WLELW+GMPAWYVAACRANVKSG
Sbjct: 316 GTQAEKDRRLKKKHQLLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSG 375
Query: 929 AIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEME 988
AIMSALSDTEIQREIGISN LHRLKLRLAIQEMVSLTSPSAPPTSRT SGNVWVTHEEME
Sbjct: 376 AIMSALSDTEIQREIGISNALHRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEME 435
Query: 989 NLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDA 1048
L KT +SEEGSWAQ TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDA
Sbjct: 436 TLETSTKT-DSEEGSWAQ------TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDA 488
Query: 1049 RMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVW 1108
RMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELE+RRE SQHEIKDVLVW
Sbjct: 489 RMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELEKRREESQHEIKDVLVW 548
Query: 1109 SNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILE 1168
+ND+V+ W+Q+IGLR+YA N+ ESGVHG+L+ALDENFD+++LAL+LQIPTQNTQARQ++E
Sbjct: 549 TNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTLALILQIPTQNTQARQVME 608
Query: 1169 REYNNLLALGTERRLDESDDKNFRRGSTWRRQFPPREVHGI-SMMPGSSETLPAGFRLTT 1227
RE+NNLLALGT+R+LD+ DDK FRR +WR++F PRE HG M+ S+ETLPAGFR++T
Sbjct: 609 REFNNLLALGTDRKLDDGDDKVFRRAPSWRKRFRPREHHGRGGMLSASAETLPAGFRVST 668
>gi|157837985 kazrin isoform E [Homo sapiens]
Length = 775
Score = 177 bits (450), Expect = 4e-44
Identities = 181/705 (25%), Positives = 302/705 (42%), Gaps = 120/705 (17%)
Query: 481 QLHLKERMAALEEK-NVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSL 539
Q+ L+E ++ L+E+ ++L Q E K+LEES K +LR +L Q +
Sbjct: 75 QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARA 134
Query: 540 IEPTIPRTHLDTSAELRYSVGSLVD--SQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGD 597
E A+ + G D SQ + R + R +R E K D
Sbjct: 135 KEALQAM-----KADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESED 189
Query: 598 HEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQL 657
++ +L +E + + D T S L + + + M ++ L
Sbjct: 190 AVKALAKEKDLLEREKWELRRQAKEATD--HATALRSQLDLKDNRMKELEAELAMAKQSL 247
Query: 658 DAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTAS--SLAS 715
+ K++ ++ S + E + L G V +TA++ S +L
Sbjct: 248 ATLTKDV----PKRHSLAMPGETV--------LNGNQEWVVQADLPLTAAIRQSQQTLYH 295
Query: 716 SSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGRE--DKATIKCET 773
S PP PA DR V P H R+ +V+ + D+++ +
Sbjct: 296 SHPPH-----------PA---DRQAVRVSPC----HSRQPSVISDASAAEGDRSSTPSDI 337
Query: 774 SPPPTPRALRMTHTL-----PSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKK 828
+ P TH+L P + + + SLE +D K K+K
Sbjct: 338 NSPR-----HRTHSLCNGDSPGPVQKNLHNPIVQSLE----------DLEDQKRKKKKEK 382
Query: 829 GIKSSIGRLF--GKKEKARLGQLRGFMETEAA-AQESLGLGKLGTQAEKDRRLKKKHELL 885
SI R+F GK+ K+ L +++ + ++SL L + Q ++ +++ EL+
Sbjct: 383 MGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSLSLSEGEEQMDRLQQV----ELV 438
Query: 886 EEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGI 945
P + W TV AWLE+ + MP YV AC NVKSG ++ +LSD ++Q +G+
Sbjct: 439 RTT-----PMSHWKAGTVQAWLEVVMAMPM-YVKACTENVKSGKVLLSLSDEDLQLGLGV 492
Query: 946 SNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWA 1005
+ LHR KLRLAI++ +++E G
Sbjct: 493 CSSLHRRKLRLAIEDY-----------------------------------RDAEAGR-- 515
Query: 1006 QCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKM 1065
+++H W+ WL +GL QY F LVD RML+ L K+DL HL +
Sbjct: 516 ------SLSKAAELDHHWVAKAWLNDIGLSQYSQAFQNHLVDGRMLNSLMKRDLEKHLNV 569
Query: 1066 VDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREY 1125
FH+ S+ GI L ++N+ R+ L+ RR + + D +VW+N RV++W++ I L+EY
Sbjct: 570 SKKFHQVSILLGIELLYQVNFSREALQERRARCETQNIDPVVWTNQRVLKWVRDIDLKEY 629
Query: 1126 ANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILERE 1170
A+N+ SGVHG+++ L+ F+ ++A L IP+ R+ L E
Sbjct: 630 ADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEE 674
Score = 45.4 bits (106), Expect = 3e-04
Identities = 53/227 (23%), Positives = 92/227 (40%), Gaps = 50/227 (22%)
Query: 205 LEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDST 264
L EE++ +E+ LR+ + + + S+G SE L
Sbjct: 78 LREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSA-------------------- 117
Query: 265 DETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQR 324
EL+ L ++ E+A+ KE L A+ + ++ E + DL+
Sbjct: 118 ------TELRVQLAQKEQELARAKEALQAMKADRKRLKGE----KTDLVS---------- 157
Query: 325 DIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQ 384
+++ A E EE++ + Y ++ES D ++ K+ + R+ E RQ
Sbjct: 158 QMQQLYATLESREEQLRDFIRNYEQHRKES------EDAVKALAKEKDLLEREKWELRRQ 211
Query: 385 LQERLELAEQKLQQTMRKAETLPEVEAELA---QRIAALTK-AEERH 427
+E + A Q K + E+EAELA Q +A LTK +RH
Sbjct: 212 AKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRH 258
Score = 40.0 bits (92), Expect = 0.014
Identities = 51/243 (20%), Positives = 106/243 (43%), Gaps = 19/243 (7%)
Query: 349 SAQRESTSIHDMNDKLENELANKEAILRQMEEKN--RQLQERLELAEQKLQQTMRKAETL 406
SA +S + + N +L ++ +E + R EE + RQ++E L + + Q + +E L
Sbjct: 57 SAAGDSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLA-KDLEESQGGKSSEVL 115
Query: 407 P--EVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKR 464
E+ +LAQ+ L +A+E ++ + L+G+ + ++Q+ + EE +
Sbjct: 116 SATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRD 175
Query: 465 LSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIE- 523
++ ES + ++ A +EK++L +E R+ +E+ L +++
Sbjct: 176 FIRNYEQHRKESEDAVK-------ALAKEKDLLEREKWELRRQAKEATDHATALRSQLDL 228
Query: 524 ------KLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRR 577
+L +EL K +L + R L E + Q+D T IR+
Sbjct: 229 KDNRMKELEAELAMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQ 288
Query: 578 PRR 580
++
Sbjct: 289 SQQ 291
>gi|29294627 PTPRF interacting protein binding protein 1 isoform 1
[Homo sapiens]
Length = 1005
Score = 155 bits (393), Expect = 2e-37
Identities = 206/878 (23%), Positives = 363/878 (41%), Gaps = 129/878 (14%)
Query: 337 EERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKL 396
+ER+ LE S + + + D + ++ + E L + EK +E L+ ++ L
Sbjct: 103 QERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQ--QELL 160
Query: 397 QQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREK 456
+T + + L ++ AE++ LT E+ + E++ R EG ++E N + + +
Sbjct: 161 SRTSLETQKL-DLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDS 219
Query: 457 MNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLE--ESLHD 514
++ K+L T D L + LKE++ E + +QE + E E +
Sbjct: 220 ERLQYEKKLKSTKDELAS---------LKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDR 270
Query: 515 KERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKV 574
E +++++ E+ ++K SL+ + D E + ++ + T V
Sbjct: 271 DENFKKKLKEKNIEVQKMKKAVESLMAANEEK---DRKIE---DLRQCLNRYKKMQDTVV 324
Query: 575 IRRPRRGRMGVRRD---EPKVKSLGDHEW--------NRTQQIGVLSSHPFESDTEMSDI 623
+ + ++G+ G + + SL D + + T +G S PF + +
Sbjct: 325 LAQGKKGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTS-----V 379
Query: 624 DDDDRETIFS-SMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAE--- 679
++ TI S+ L P+ T++M E+ K +E + L A
Sbjct: 380 PEEFHTTILQVSIPSLLPA------TVSMETSEKSKLTPKPETSFEENDGNIILGATVDT 433
Query: 680 EIENRVASVSLE-GLNLARVHPGTSITASVTASSLASSSPPSGHSTP--KLTPRSPAREM 736
++ +++ + SL+ +L + TS T + P+ S P L PR P ++
Sbjct: 434 QLCDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPA-ESRPFGTLPPRPPGQDT 492
Query: 737 DR----MGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRALRMTHTLPSSY 792
G + S + KI + K S P + T +
Sbjct: 493 SMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLDRKRSASAPTLAETEKET-----AE 547
Query: 793 HNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGF 852
H D + S + + NS +P K I +LFGK R Q F
Sbjct: 548 HLDLAGASSRPKDSQR------NSPFQIPPPSPDSKKKSRGIMKLFGK---LRRSQSTTF 598
Query: 853 METEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWL-ELWL 911
+ + E + GT+A RL +L + +PFA+W V WL E L
Sbjct: 599 NPDDMSEPE---FKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCNWLMEQGL 655
Query: 912 GMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPP 971
G Y+ + + + SG + S ++++E+GI + LHR KL+LA+Q + S
Sbjct: 656 GS---YLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGS-------- 704
Query: 972 TSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPS 1031
EE N +G ++ W+ WL
Sbjct: 705 -------------EEETN--------------------------HGKLDFNWV-TRWLDD 724
Query: 1032 LGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKEL 1091
+GLPQY++ F E VD RML ++T DL + LK+V H S++ I L+ N++ L
Sbjct: 725 IGLPQYKTQFDEGRVDGRMLHYMTVDDL-LSLKVVSVLHHLSIKRAIQVLRINNFEPNCL 783
Query: 1092 ERRREASQHEI--KDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSS 1149
RRR + ++ I +V W+N RV+ W++++ L EYA N+ SGVHG L+ L+ F+ +
Sbjct: 784 -RRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVET 842
Query: 1150 LALLLQIPTQNTQARQILEREYNNLLALGTERRLDESD 1187
+A LL IP T R+ L +N L +G E + + D
Sbjct: 843 MAQLLNIPPNKTLLRRHLATHFN--LLIGAEAQHQKRD 878
>gi|170784854 PTPRF interacting protein, binding protein 2 (liprin
beta 2) [Homo sapiens]
Length = 876
Score = 149 bits (377), Expect = 1e-35
Identities = 207/825 (25%), Positives = 350/825 (42%), Gaps = 137/825 (16%)
Query: 379 EEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLE 438
EE Q+ + + Q+ + + E E L +++ LT E G E++R LE
Sbjct: 90 EESLSQVNHHSAASNETYQERLARLEGDKE---SLILQVSVLTDQVEAQG---EKIRDLE 143
Query: 439 GQLEEKNQELQRARQREKMNEEHNKRLSDTVDRL--LTESNE-RLQL-HLKERMAALEEK 494
LE +L A E + +E R S +L +TE +E +L+L +++ EEK
Sbjct: 144 VCLEGHQVKLNAAE--EMLQQELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEK 201
Query: 495 N----VLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLD 550
L+QE + +EE +++ + +++ ++E+ QL+ + +L + I R H
Sbjct: 202 QRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEVAQLQEQV-ALKDAEIERLHSQ 260
Query: 551 TSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVR-RDEPKVKSLGD-----HEWNRTQ 604
S + + S+S + I+R + G + +E K + + + +++ + +
Sbjct: 261 LSRT------AALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVK 314
Query: 605 QIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKE- 663
+I +++ P E I++++ E FS + + + D + L QE +
Sbjct: 315 EIVMVTQGPSERTLS---INEEEPEGGFSKWN----ATNKDPEEL--FKQEMPPRCSSPT 365
Query: 664 IRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHS 723
+ ++S E RA+ + S SLE L S + + P
Sbjct: 366 VGPPPLPQKSLETRAQ----KKLSCSLEDLR------------SESVDKCMDGNQPFPVL 409
Query: 724 TPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRALR 783
PK +P + TLP L A + + TI C+ P T +L
Sbjct: 410 EPKDSPFLAEHKYP-----TLPGKLSG-----ATPNGEAAKSPPTI-CQ--PDATGSSLL 456
Query: 784 MTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKK--KGIKSSIGRLFGKK 841
S + + A V + S G+ + Q L K+ KGIK + +GK
Sbjct: 457 RLRDTESGWDDTA-----VVNDLSSTSSGTESGPQSPLTPDGKRNPKGIK----KFWGKI 507
Query: 842 EKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGP 901
+ + G + +T A+ G G +A RL + + + PFAQW
Sbjct: 508 RRTQSGNF--YTDTLGMAEFRRG----GLRATAGPRLSRTRDSKGQKSDANAPFAQWSTE 561
Query: 902 TVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEM 961
V AWLE + G+ A YV R V SG + + ++++E+GI +PLHR KL LA++ +
Sbjct: 562 RVCAWLEDF-GL-AQYVIFARQWVSSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAI 619
Query: 962 VSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNH 1021
TK+ E+ + ++H
Sbjct: 620 ---------------------------------NTKQEEKSAL--------------LDH 632
Query: 1022 EWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCL 1081
W+ WL +GLPQY+ F E VD RML +LT DL + LK+ H S++ I L
Sbjct: 633 IWV-TRWLDDIGLPQYKDQFHESRVDGRMLQYLTVNDL-LFLKVTSQLHHLSIKCAIHVL 690
Query: 1082 KRLNYDRKELERR-REASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIA 1140
++ L RR + S +V+ WSN RV+ W++++ L EYA N+ SGVHG LI
Sbjct: 691 HVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLII 750
Query: 1141 LDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDE 1185
L+ F +LA+LL IP Q T R+ L ++N L+ E+ E
Sbjct: 751 LEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKRE 795
Score = 42.4 bits (98), Expect = 0.003
Identities = 45/228 (19%), Positives = 100/228 (43%), Gaps = 16/228 (7%)
Query: 274 QELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDL-IKTEEMNTKYQRDIREAMAQ 332
+E L + N+ A E R+ +E + E+ + + T+++ + ++ IR+
Sbjct: 90 EESLSQVNHHSAASNE---TYQERLARLEGDKESLILQVSVLTDQVEAQGEK-IRDLEVC 145
Query: 333 KEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELA 392
E + ++ E+ TS+ L E++ + L ME++ R+ +E+ A
Sbjct: 146 LEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKA 205
Query: 393 EQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRAR 452
E+ LQ+ + E+E E Q L + ++E++ + ++E + +L R
Sbjct: 206 EELLQELRHLKIKVEELENERNQYEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTA 265
Query: 453 QREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQE 500
+E H +R + +RL++ ++ + A E+K+ I+E
Sbjct: 266 ALH--SESHTER---------DQEIQRLKMGMETLLLANEDKDRRIEE 302
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 110 bits (274), Expect = 1e-23
Identities = 189/972 (19%), Positives = 391/972 (40%), Gaps = 102/972 (10%)
Query: 32 EQLMVNMLDERDRLLDTLRETQESLSLAQQRL-------QDVIYDRDSLQRQLNSALPQD 84
+++M++ L+ER L +T++ L A+++L QD I + + +L L +
Sbjct: 1032 QEVMISDLEER---LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 85 IESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNT----RLLLEH 140
E L G LA + AL K + + Q+ E +E+ KA RN R L E
Sbjct: 1089 EEELQGALARGDDETLHKNNAL-KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147
Query: 141 LECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLE 200
LE L + E +L T +++ ++ E+ KAL+ ++H+A + +R+R +LE
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKRE-QEVAELKKALEEETKNHEAQIQDMRQRHATALE 1206
Query: 201 RVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGS 260
+S E+L A + L + ++ + E + E + L+ ++ + K+L
Sbjct: 1207 ELS---EQLEQAKRFKANLEKNKQGLETD--NKELACEVKVLQQVKAESEHKRKKLD--- 1258
Query: 261 IDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNT 320
+Q+ EL + + + ++ E+ + L + + V E A K IK
Sbjct: 1259 -------AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIK------ 1305
Query: 321 KYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEE 380
+ +D +Q +D +E + ++ L+ + + + L+ + +E + +E+
Sbjct: 1306 -FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK 1364
Query: 381 KNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEER----HGNIEERMRH 436
+ LQ +L ++K+ + E+L E + +L + AL++ E + +E+
Sbjct: 1365 QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 437 LEGQLEEKNQELQRARQ----REKMNEEHNKRLSD--TVDRLLTESNERLQLHLKERMA- 489
L+ +L++ +L RQ EK ++ ++ L++ ++ E +R + +E+
Sbjct: 1425 LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETK 1484
Query: 490 ----------ALEEKNVLIQESETFRKNLEESLHDKERLAE---EIEKLRSELDQLKMRT 536
ALE K ++++ R ++E+ + K+ + + E+EK + L+Q
Sbjct: 1485 ALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEM 1544
Query: 537 GSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYR--TTKVIRRPRRGRMGVRRDEPKVKS 594
+ +E A+LR V R T+ + + R+ +++
Sbjct: 1545 RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAE 1604
Query: 595 LGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQ 654
L D R + + + +ID D E + + + LQ
Sbjct: 1605 LEDERKQRALAV---------ASKKKMEIDLKDLEAQIEAAN----KARDEVIKQLRKLQ 1651
Query: 655 EQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLA 714
Q+ +E+ + ++ +++E E ++ S+ E L L LA
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQL--------------QEELA 1697
Query: 715 SSSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETS 774
SS H+ + + G L + R+ +IA +EE+ E+++ ++
Sbjct: 1698 SSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 775 PPPTPRALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSI 834
R T + + + + S + + ++ +++ K + +G S
Sbjct: 1758 ------RFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811
Query: 835 GRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLP 894
+ +A++GQL +E E A+E KL + EK +LK+ +E+ RR
Sbjct: 1812 FKATISALEAKIGQLEEQLEQE--AKERAAANKLVRRTEK--KLKEIFMQVEDERRHADQ 1867
Query: 895 FAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKL 954
+ + +L + A RAN + L D E G+S + LK
Sbjct: 1868 YKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANE-GLSREVSTLKN 1926
Query: 955 RLAIQEMVSLTS 966
RL +S +S
Sbjct: 1927 RLRRGGPISFSS 1938
Score = 92.0 bits (227), Expect = 3e-18
Identities = 134/621 (21%), Positives = 267/621 (42%), Gaps = 76/621 (12%)
Query: 115 EQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSL-RMTVVKRQAQSPSGVSSEVEV 173
E+L K+EE+ ++K ++ LE +E +H++ L ++ Q Q+ + + +E E
Sbjct: 852 EELQAKDEELLKVKEKQTKVEGELEEME---RKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 174 LKA-LKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALRE---------QN 223
++A L + + + + + R+ ER L+ E I L E Q
Sbjct: 909 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 224 VHIQRKMASSEGSTESEHLEGME-------PGQKVHEKRLSNGSIDSTDETSQIVELQEL 276
+ +++ A ++ E + +E +K+ E R++ S +E + L ++
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 277 LEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDM 336
KQ ++ ++ERL + + QE E A++ K + T Q I E AQ +++
Sbjct: 1029 RNKQEVMISDLEERL----KKEEKTRQELEKAKR---KLDGETTDLQDQIAELQAQIDEL 1081
Query: 337 EERITTLEKRYLS--AQRESTSIHDMN------------DKLENELANKEAILRQMEEKN 382
+ ++ E+ A+ + ++H N +L+ + +++A + E++
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141
Query: 383 RQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEE------RMRH 436
R L E LE + +L+ T+ E+ + Q +A L KA E E R RH
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Query: 437 LEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNV 496
LEE +++L++A+ R K N E NK+ +T ++ L + LQ E ++ +
Sbjct: 1202 ATA-LEELSEQLEQAK-RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 497 LIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELR 556
+QE + E + LAE+ KL++ELD + +L+E + +
Sbjct: 1260 QVQE---LHAKVSEGDRLRVELAEKASKLQNELDNV----STLLEEAEKK-----GIKFA 1307
Query: 557 YSVGSLVDSQSDYRTTKVIRRPRRGRMG----VRRDEPKVKSLGDHEWNRTQQIGVLSSH 612
SL D T ++++ R ++ +R+ E + SL + + + L
Sbjct: 1308 KDAASLESQLQD--TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ 1365
Query: 613 PFESDTEMSDID---DDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQ---LDAINKEIRL 666
++++D DDD TI S++ DA+ L+ L+E+ D + K
Sbjct: 1366 VLALQSQLADTKKKVDDDLGTI-ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNR 1424
Query: 667 IQEEKESTELRAEEIENRVAS 687
+Q+E + + + + +VAS
Sbjct: 1425 LQQELDDLTVDLDH-QRQVAS 1444
Score = 87.0 bits (214), Expect = 1e-16
Identities = 125/541 (23%), Positives = 240/541 (44%), Gaps = 57/541 (10%)
Query: 174 LKALKSLFEHHKALDEKVRERLRVSLE--RVSALEEELAAANQEIVALREQNVHIQRKMA 231
+K L + + L K E L+V + +V EE+ +Q++ L E+N+ ++ A
Sbjct: 841 VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQL--LEEKNILAEQLQA 898
Query: 232 SSEGSTESEHLEGMEPGQKVHEKRLSN---GSIDSTDETSQIVELQELLEKQNYEMAQMK 288
+E E+E + +K + + + ++ +E +QI LQ +K + ++
Sbjct: 899 ETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI--LQNEKKKMQAHIQDLE 956
Query: 289 ERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYL 348
E+L +++ E TA + K EE + + + +K+ ME+RI +
Sbjct: 957 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA 1016
Query: 349 SAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQ-QTMRKAETLP 407
+ ++ ++ + +K E +++ E L++ EEK RQ LE A++KL +T + +
Sbjct: 1017 EEEEKAKNLAKIRNKQEVMISDLEERLKK-EEKTRQ---ELEKAKRKLDGETTDLQDQIA 1072
Query: 408 EVEAELAQRIAALTKAEE--------------RHGNIEERMRHLEGQLEEKNQELQRARQ 453
E++A++ + L K EE N + +R L+ Q+ E ++ + +
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 454 REKMNEEHNKRLSDTVDRLLTESNERL-------QLHLKERMAALEEKNVLIQESETFRK 506
E+ + LS+ ++ L TE + L +L K E K L +E+ K
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET----K 1188
Query: 507 NLEESLHD-KERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDT-SAELRYSVGSL-- 562
N E + D ++R A +E+L +L+Q K +L + + L+T + EL V L
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK---NKQGLETDNKELACEVKVLQQ 1245
Query: 563 VDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSD 622
V ++S+++ K+ + V+ KV S GD R + S E D +
Sbjct: 1246 VKAESEHKRKKLDAQ-------VQELHAKV-SEGDR--LRVELAEKASKLQNELDNVSTL 1295
Query: 623 IDDDDRETIFSSMDLLS-PSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEI 681
+++ +++ I + D S S D Q L Q ++ IR ++EEK S + + EE
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEE 1355
Query: 682 E 682
E
Sbjct: 1356 E 1356
Score = 77.8 bits (190), Expect = 6e-14
Identities = 118/516 (22%), Positives = 217/516 (42%), Gaps = 89/516 (17%)
Query: 17 QRGSQSSGSDSDSHFEQLMVN-------MLDERDRLLDTLRETQ-ESLSLAQQRLQDVIY 68
QR S+ F+QL+ +ERDR RE + ++LSLA+ L++ +
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARA-LEEALE 1497
Query: 69 DRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFA----ALTKELNACREQLLEKEEEI 124
++ +RQ N L D+E L G + E AL +++ R QL E E+E+
Sbjct: 1498 AKEEFERQ-NKQLRADMEDLMSS-KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 125 -----SELKAERNNTRLLLEHLECLVSRHE-------------RSLRMTVVKRQAQSPSG 166
++L+ E N + + L +R E R L + + Q
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALA 1615
Query: 167 VSSEVEV---LKALKSLFEH-HKALDEKVRERLRVS---------LERVSALEEELAAAN 213
V+S+ ++ LK L++ E +KA DE +++ ++ LE A +E+ A +
Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS 1675
Query: 214 QE----IVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDET-- 267
+E + +L + + +Q ++ASSE + E E ++ ++G DE
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS--ASGKSALLDEKRR 1733
Query: 268 --SQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRD 325
++I +L+E LE++ M + +R + +V + E R K++ + +R
Sbjct: 1734 LEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQ 1793
Query: 326 IREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQL 385
+E A+ +++E + + K +SA I + ++LE E + A + + ++L
Sbjct: 1794 NKELKAKLQELEGAVKSKFKATISALE--AKIGQLEEQLEQEAKERAAANKLVRRTEKKL 1851
Query: 386 QERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKN 445
+E E + + + E + + A RM+ L+ QLEE
Sbjct: 1852 KEIFMQVEDERRHADQYKEQMEKANA---------------------RMKQLKRQLEEAE 1890
Query: 446 QELQRAR-QREKMNEEHNKRLSDTVDRLLTESNERL 480
+E RA R K+ E L D TE+NE L
Sbjct: 1891 EEATRANASRRKLQRE----LDDA-----TEANEGL 1917
Score = 45.8 bits (107), Expect = 3e-04
Identities = 69/324 (21%), Positives = 125/324 (38%), Gaps = 41/324 (12%)
Query: 369 ANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEV---EAELAQRIAALTKAEE 425
A K+ L ++ R L+L + + K + L +V E EL + L K +E
Sbjct: 807 AKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKE 866
Query: 426 RH----GNIEERMRHLEGQLEEKN---QELQRARQREKMNEEHNKRLSDTVDRLLTESNE 478
+ G +EE R + LEEKN ++LQ + EE RL+ L E
Sbjct: 867 KQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQEL-----E 921
Query: 479 RLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGS 538
+ L+ R+ EE+N ++Q +K ++ + D E +E E R +L K+ +
Sbjct: 922 EILHDLESRVEEEEERNQILQNE---KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEA 978
Query: 539 LIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMG--VRRDEPKVKSLG 596
I+ ++ + L D S + K + R + +E K K+L
Sbjct: 979 KIK------------KMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 597 DHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQ 656
+ I L + + +++ R+ + DL Q LQ Q
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL---------QDQIAELQAQ 1077
Query: 657 LDAINKEIRLIQEEKESTELRAEE 680
+D + ++ +EE + R ++
Sbjct: 1078 IDELKLQLAKKEEELQGALARGDD 1101
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 103 bits (256), Expect = 1e-21
Identities = 147/707 (20%), Positives = 312/707 (44%), Gaps = 106/707 (14%)
Query: 52 TQESLSLAQQRLQ------DVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAA 105
T+E L+Q+ ++ ++ + + L ++S L +E L + S+ + E A
Sbjct: 1815 TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAI--SETSSQLEHAK 1872
Query: 106 LTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPS 165
+T + RE +K+E LK + L E L HE S + +
Sbjct: 1873 VT-QTELMRESFRQKQEATESLKCQEE----LRERL------HEESRAREQLAVELSKAE 1921
Query: 166 GVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVH 225
GV ++ K+LFE + +RL L S +EL A Q+I RE
Sbjct: 1922 GV---IDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSR 1978
Query: 226 IQRKMASSEGSTESEHLEGMEP-----------GQKVHE---KRLSNGSIDSTDETSQIV 271
+ M + G E + L+ E +KV + K++ ID ++ S+ +
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 272 ELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMA 331
EL++ ++N E+ ++++ AL E++ E RK + + ++ +++RD+ +
Sbjct: 2039 ELEQ---EKNTELMDLRQQNQAL-------EKQLEKMRK-FLDEQAIDREHERDVFQQEI 2087
Query: 332 QKEDMEERITTL-----EKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQ 386
QK + + ++ E + ++ + + + DK L +KE + R ++E+N ++
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEI- 2146
Query: 387 ERLELAEQKLQQTM----RK----AETLPEV--EAELAQRIAALTKAEERHGNIEERMRH 436
E+LE ++L+Q + RK E PE+ E +L A+ + E+ N+EE++
Sbjct: 2147 EKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2206
Query: 437 LEGQLEEKNQELQRAR-QREKMNEEHNKRLS--DTVDRLLTESNERLQLHLKERMA-ALE 492
+LE KN+E+Q+ Q E +E RL + ++L + E+L L +KE A + +
Sbjct: 2207 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2266
Query: 493 EKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTS 552
+++VL + F + ++E + ++L E++ KL+ QLK+ T + + ++
Sbjct: 2267 DQHVLFGK---FAQIIQEKEVEIDQLNEQVTKLQ---QQLKITTDNKV--------IEEK 2312
Query: 553 AELRYSVGSLVDS-QSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSS 611
EL + + ++ SD K R E +++ L + Q++ +
Sbjct: 2313 NELIRDLETQIECLMSDQECVK------------RNREEEIEQLNEVIEKLQQELANIGQ 2360
Query: 612 HPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEK 671
+ +S ++ +++ +D++ A+ LA L++Q++ N+E+ ++
Sbjct: 2361 KTSMNAHSLS----EEADSLKHQLDVVI------AEKLA--LEQQVETANEEMTFMKNVL 2408
Query: 672 ESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSP 718
+ T + ++ + S+ E ++ ++ + +V L+ P
Sbjct: 2409 KETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP 2455
Score = 88.6 bits (218), Expect = 3e-17
Identities = 147/714 (20%), Positives = 301/714 (42%), Gaps = 98/714 (13%)
Query: 26 DSDSHFEQLMVNMLDERDRLLDT----------LRETQESLSLAQQRLQDVIYD-RDSLQ 74
+ ++ E+L +++E + L+ L E QE + Q ++++ + +S Q
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQ 385
Query: 75 RQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNT 134
++ S+ ++I+ L G + + + + T + + E + ++ +L+AE +
Sbjct: 386 KERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ---ETQRKLEQLRAELDEM 440
Query: 135 --RLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEV-------------LKALKS 179
+ +++ + L+ +H + + + + + + S + + L
Sbjct: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500
Query: 180 LFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTES 239
+ + EK++E L + LE AL+ +L +E+ REQ ++ +A E
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 240 EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNY----EMAQMKERLAALS 295
H + + I S E+ + +EL+ E NY EM + KE+ A L
Sbjct: 561 AH-------KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE-KEKNAVLD 612
Query: 296 SRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDME-ERITTLEKRYLSAQRES 354
E E E R L+ + E E KED+E E +EK +++
Sbjct: 613 RMAESQEAELERLRTQLLFSHE---------EELSKLKEDLEIEHRINIEKL-----KDN 658
Query: 355 TSIH--DMNDKLENELANKEAILRQMEEKN---RQLQERLELAEQK-LQQTM--RKAETL 406
IH D L+NE++ K + Q E+ N +Q Q LE+++ K LQQ++ K+E +
Sbjct: 659 LGIHYKQQIDGLQNEMSQKIETM-QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEM 717
Query: 407 PEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLS 466
EL + I L + E+ G +E+ ++ L+ EL + +EK N+ K
Sbjct: 718 TLQINELQKEIEILRQEEKEKGTLEQEVQELQ-----LKTELLEKQMKEKENDLQEKFAQ 772
Query: 467 -DTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKL 525
+ + +L + + L+ LK +E+ ++ +S + ++S+ +KE IE L
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS--IKSKSKDSVWEKE-----IEIL 825
Query: 526 RSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGV 585
E + LK + L E + + + AE + V + + Q +Y ++
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV-NYQELQEEYACLLKVKDDLEDSKNK 884
Query: 586 RRDEPKVKSLGDHEWNRTQQIGV----LSSHPFESDT-------EMSDIDDDDRETIFSS 634
+ E K K +E Q+I + S F+ D EM ++ + D +
Sbjct: 885 QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944
Query: 635 MDLLSPSGHSDAQTLAMMLQE------QLDAINKEIRLIQEEKESTELRAEEIE 682
+++ +Q L+ + ++ ++ +N+E++ +++EKE LR E+E
Sbjct: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998
Score = 84.7 bits (208), Expect = 5e-16
Identities = 146/741 (19%), Positives = 320/741 (43%), Gaps = 104/741 (14%)
Query: 12 DTPMSQRGSQSSGSDSDSHFEQLMVNM------LDERDRLLDTLRETQESLSLAQ-QRLQ 64
D S++G+Q DS +H E + + ++E +R L+ +R T + L Q Q +
Sbjct: 142 DDSYSEQGAQ----DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFE 197
Query: 65 DVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEI 124
I RD + QL + L Q K EF LT++ + Q + +
Sbjct: 198 AAIKQRDGIITQLTANLQQ--------ARREKDETMREFLELTEQSQKLQIQFQQLQASE 249
Query: 125 SELKAERNNTRLLLEHLECLVSRHERSLRMT--VVKRQAQSPSGVSSEVEVLKALKSLFE 182
+ + ++T L + + H++ L +++ + + ++ L+ ++E
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE 309
Query: 183 HHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHL 242
+ D+KV + ++ + EEL N +I+ ++ + ++ K+ +++
Sbjct: 310 MEQ--DKKVENSNKEEIQEKETIIEEL---NTKIIEEEKKTLELKDKLTTADKLLGELQE 364
Query: 243 EGMEPGQKVHEKRLS-----NGSIDSTDETSQIVELQELLEKQNYEMAQMK--------- 288
+ ++ Q++ +L S++E Q++ E L+K+N++ +Q +
Sbjct: 365 QIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ 424
Query: 289 ---ERLAALSSRVGE------VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEER 339
+L L + + E V+ + E R+ + + EEM T+++ ++ A+ +
Sbjct: 425 ETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN---- 480
Query: 340 ITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQ----MEEK---NRQLQERLELA 392
IT E + + + +I+++N KL++ + KE + + +EEK RQL++ +E
Sbjct: 481 ITVNEDQ---IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
Query: 393 EQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQ-ELQRA 451
+Q R +T+ E E++L + +L+ E+ I + +LE K++ E+
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK-ELELKHEAEVTNY 596
Query: 452 RQREKMNEEHNKRLSDTVDRLLTESNERLQLHL----KERMAALEEKNVLIQESETFRKN 507
+ + +M E+ + D + ERL+ L +E ++ L+E + +
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK 656
Query: 508 LEESLHDKER-------LAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVG 560
+H K++ ++++IE ++ E D L + LI L+ S +L+
Sbjct: 657 DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI--------LEIS-KLKDLQQ 707
Query: 561 SLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQ-QIGVLSSHPFESDTE 619
SLV+S+S+ T ++ + + + R E K K + E Q + +L E + +
Sbjct: 708 SLVNSKSEEMTLQI--NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEND 765
Query: 620 MSD----------IDDDDRETIFSSMDLLSPSGHSDAQT-LAMMLQEQLDAI-NKEIRLI 667
+ + I D+++T+ + + +P + L + + D++ KEI ++
Sbjct: 766 LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 668 QEEKESTELRA----EEIENR 684
EE E + + EEIE +
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQ 846
Score = 78.2 bits (191), Expect = 5e-14
Identities = 109/554 (19%), Positives = 232/554 (41%), Gaps = 67/554 (12%)
Query: 25 SDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQ-------- 76
+D + FE+ + D DRL L L + Q + +R+ L RQ
Sbjct: 1928 ADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEA 1987
Query: 77 --LNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNT 134
+ L Q+ E L + L K++ A + E+ EL+ E+N
Sbjct: 1988 GPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTE 2047
Query: 135 RLLL----EHLECLVSRHERSLRMTVVKRQ------AQSPSGVSSEVEVLKALKSLFEHH 184
+ L + LE + + + L + R+ Q + +++V+ + + EH
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 185 KALDEKVRERLRVSLERVS-------ALEEELAAANQEIVALREQNVHIQRKMASSE--- 234
E++ L+ ++ S L+ ++ N+EI L + +++ + +
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKH 2167
Query: 235 -GSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERL-- 291
G+ E++ +E + + + T+ Q+ + +E LE +N E+ Q+ +L
Sbjct: 2168 FGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2227
Query: 292 --AALSSRVGEVEQEAETARKDLIK-------TEEMNT--------KYQRDIREAMAQKE 334
++R+ E+EQE + + D+ K ++ M+T K+ + I+E + +
Sbjct: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID 2287
Query: 335 DMEERITTLEKRYLSA------QRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQER 388
+ E++T L+++ + ++ I D+ ++E ++++E + R EE+ QL E
Sbjct: 2288 QLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV 2347
Query: 389 LELAEQKL----QQTMRKAETLPE----VEAELAQRIAALTKAEERHGNIEERMRHLEGQ 440
+E +Q+L Q+T A +L E ++ +L IA E++ E M ++
Sbjct: 2348 IEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNV 2407
Query: 441 LEEKNQELQRARQR---EKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVL 497
L+E N ++ + Q K E +++ + + + + L E L E +
Sbjct: 2408 LKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALK 2467
Query: 498 IQESETFRKNLEES 511
E++T+ K+ EE+
Sbjct: 2468 SLENQTYFKSFEEN 2481
Score = 65.1 bits (157), Expect = 4e-10
Identities = 112/556 (20%), Positives = 230/556 (41%), Gaps = 80/556 (14%)
Query: 20 SQSSGSDSDSH-FEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLN 78
++S SD + H +Q+ L+ER ++T+ ++ ++ Q + + +YD +
Sbjct: 2953 TESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFS 3012
Query: 79 SALPQDIESLTGGLAGSKGADPPEFAALTKELNA-----------CREQLLEKEEEISEL 127
+ + +L + AA EL A C EQ + +E+ E
Sbjct: 3013 DWRGELLLALQQVFLEERSV---LLAAFRTELTALGTTDAVGLLNCLEQRI--QEQGVEY 3067
Query: 128 KAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPS---GVSSEVEVLKALKSLFEHH 184
+A +ECL RSL + AQ + E E K + L E++
Sbjct: 3068 QAA----------MECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 3117
Query: 185 KALDEKVRERLRVSLE------RVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTE 238
+ +K + L + +E R + L+E+L++ + L+ SE +
Sbjct: 3118 --IQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK------------SELAQT 3163
Query: 239 SEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRV 298
LE Q H K L ++ D+T ++ L + L + + +++ L +++
Sbjct: 3164 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3223
Query: 299 GEVEQEAETARKDLIKTEEMNTKYQRDIREAM---AQKEDMEERITTLEKRYLSAQREST 355
G E+ + +DL + ++ QR+++ + QK+ + E +E + + + +
Sbjct: 3224 GRSEERDKEELEDL--KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS 3281
Query: 356 SIHDMNDKLENELANKEAILRQME---EKNRQLQERLELAEQKLQQ--TMRKAETLPEVE 410
N +L+ L +++ +R+M ++ R+L +L+ ++ Q + + L E++
Sbjct: 3282 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3341
Query: 411 AELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVD 470
+L EE+H I E + E + K LQ +Q EK + H K L T
Sbjct: 3342 KQL----------EEKHSRIVELLNETE---KYKLDSLQTRQQMEKDRQVHRKTL-QTEQ 3387
Query: 471 RLLTESNER---LQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRS 527
TE ++ LQ +++ LEEK + + + + L+ + + ++ E E+ R
Sbjct: 3388 EANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKR- 3446
Query: 528 ELDQLKMRTGSLIEPT 543
+ ++ +L EPT
Sbjct: 3447 --ESRRILYQNLNEPT 3460
Score = 64.7 bits (156), Expect = 5e-10
Identities = 102/495 (20%), Positives = 205/495 (41%), Gaps = 86/495 (17%)
Query: 102 EFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQA 161
E +++ +EQL ++ ++ELK+E T+L LE L ++H+ + + +
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELE--TTLKAQHKHLKELEAFRLEV 3188
Query: 162 QSPSG--------VSSEVEVLKALKSLFEHHKAL-------DEKVRERLRVSLERVSA-- 204
+ + ++SE + + L+ E KA D++ E L+ SLE
Sbjct: 3189 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3248
Query: 205 ------LEEELAAANQEIVALREQNVHIQRKMASSEGST-------ESEHLEGMEPGQKV 251
LE++ N+ + Q + +++ +G ESE + E +
Sbjct: 3249 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3308
Query: 252 HEKRLSNGSIDSTDETSQ----------IVELQELLEKQNYEMAQM-----KERLAALSS 296
+R + + S+D T Q + ELQ+ LE+++ + ++ K +L +L +
Sbjct: 3309 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368
Query: 297 RVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTS 356
R ++E++ + RK L +E NT+ Q+ + E ++ ED++ R L +R+
Sbjct: 3369 RQ-QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ--------RQLEEKRQQVY 3419
Query: 357 IHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAE---- 412
KL+ E + I+++ +++ + +E+ E + + L Q + + T
Sbjct: 3420 ------KLDLEGQRLQGIMQEFQKQELEREEKRE-SRRILYQNLNEPTTWSLTSDRTRNW 3472
Query: 413 -LAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQR------------EKMNE 459
L Q+I TK E + + E + G N EL+ RQ+ +K +E
Sbjct: 3473 VLQQKIEGETK-ESNYAKLIE----MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3527
Query: 460 EHNKRLSDTVDRLLTESN-ERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERL 518
+D D + + N + + L L++ E+ L+ S + E L L
Sbjct: 3528 RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAEL 3587
Query: 519 AEEIEKLRSELDQLK 533
I +L E + L+
Sbjct: 3588 TGHISQLTEEKNDLR 3602
Score = 59.7 bits (143), Expect = 2e-08
Identities = 139/701 (19%), Positives = 269/701 (38%), Gaps = 186/701 (26%)
Query: 37 NMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSK 96
N++ ER+R+L E + LSLA + S Q Q + ++E T
Sbjct: 1647 NLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT------- 1699
Query: 97 GADPPEFAALTKELNACREQL---LEKEEEISELKAERNNTRLLLEHLECLVSRHERSLR 153
KEL+ E + + E + KA ++LLE ++ + E R
Sbjct: 1700 --------FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 154 --MTVVKRQAQSPSGVS----SEVEVLKALKSLF--EHHKALDEKV-----RERLRVSLE 200
+ ++ R ++S S S SE E ++KS EH + DE + + R +
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEA--SVKSCVHEEHTRVTDESIPSYSGSDMPRNDIN 1809
Query: 201 RVSALEEELAAANQEIVA-------LREQNVHIQRKMAS-------------SEGSTESE 240
S + EE +Q +V + +N + ++S SE S++ E
Sbjct: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE 1869
Query: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAA-LSSRVG 299
H KV + L S E ++ ++ QE L ++ +E ++ +E+LA LS G
Sbjct: 1870 HA-------KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEG 1922
Query: 300 EVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHD 359
++ A+ T ++R I+E D
Sbjct: 1923 VIDGYADE-----------KTLFERQIQEKT----------------------------D 1943
Query: 360 MNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKA-----ETLPEVEAELA 414
+ D+LE EL L+++E + +Q+QE EL ++ + +A + L E E +
Sbjct: 1944 IIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
Query: 415 QRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLT 474
+++ +AE+ +++++++ LE +EE+ ++ +E N L D L
Sbjct: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI------ELEQEKNTELMD-----LR 2052
Query: 475 ESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKM 534
+ N+ L+ L++ L+E+ + + H+++ +EI+KL +L
Sbjct: 2053 QQNQALEKQLEKMRKFLDEQAI-------------DREHERDVFQQEIQKLEQQLK---- 2095
Query: 535 RTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKS 594
+PR + + R +V+
Sbjct: 2096 --------VVPRFQPISEHQTR----------------------------------EVEQ 2113
Query: 595 LGDHEWNRTQQIG--VLSSHPFESDTEMSDIDDDDRETIFSSMD---LLSPSGHSDAQ-- 647
L +H +T + +LS + D + + + + E ++ L+ H A
Sbjct: 2114 LANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEA 2173
Query: 648 ----TLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENR 684
+L + LQ + DAI+++ + I +E E EE+EN+
Sbjct: 2174 KPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENK 2214
Score = 55.1 bits (131), Expect = 4e-07
Identities = 99/440 (22%), Positives = 194/440 (44%), Gaps = 72/440 (16%)
Query: 151 SLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEE-- 208
SL+ + K Q Q E EV + +S H++ + R L ++L++V E
Sbjct: 2985 SLKDLITKMQLQR------EAEVYDSSQS----HESFSDW-RGELLLALQQVFLEERSVL 3033
Query: 209 LAAANQEIVAL----------------REQNVHIQRKMASSEGS------TESEHLEGME 246
LAA E+ AL +EQ V Q M + + +E + L
Sbjct: 3034 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 3093
Query: 247 PGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAE 306
G+K+ KR +S + +++E ++++ +M +M+ L+++ R E++++
Sbjct: 3094 NGRKITLKREQ----ESEKPSQELLEYN--IQQKQSQMLEMQVELSSMKDRATELQEQLS 3147
Query: 307 TARKDL--IKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKL 364
+ + + +K+E TK + + AQ + ++E LE L + ++ +H +ND L
Sbjct: 3148 SEKMVVAELKSELAQTKLELETT-LKAQHKHLKE----LEAFRLEVKDKTDEVHLLNDTL 3202
Query: 365 ENELANKEAILRQMEEKNRQL-----QERLELAEQKLQQTMRKAETLPEVEAELAQRIAA 419
+E + +E++ +L +++ EL + K +K L ++ L Q+
Sbjct: 3203 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL-QLNLLLEQQKQL 3261
Query: 420 LTKAEERHGNIEERMRHLEGQLEE---KNQELQRARQREKMNEEHNKRLSDTVDRLLTES 476
L +++++ IE + + QL E +N ELQ + EK+ + +S T+DR
Sbjct: 3262 LNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKV---RIREMSSTLDR----- 3310
Query: 477 NERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEI--EKLRSELDQLKM 534
ER +LH + + + ++ SE K L++ L +K E+ E + +LD L+
Sbjct: 3311 -ER-ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3368
Query: 535 RTGSLIEPTIPRTHLDTSAE 554
R + + R L T E
Sbjct: 3369 RQQMEKDRQVHRKTLQTEQE 3388
Score = 48.9 bits (115), Expect = 3e-05
Identities = 65/344 (18%), Positives = 153/344 (44%), Gaps = 25/344 (7%)
Query: 109 ELNACREQLLEKEE----EISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQA--- 161
EL C +Q+ + +E E L+ + N + ++E E + + +++ V+ A
Sbjct: 2506 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE--EKVAAALVSQIQLEAVQEYAKFC 2563
Query: 162 QSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALRE 221
Q +SSE E ++ ++ ++++ + R+S LE ++ + ++ +E
Sbjct: 2564 QDNQTISSEPE----RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE 2619
Query: 222 QNVHIQRKMASSEGSTES--EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEK 279
Q ++ + E + LEG E Q+ EK+ S ++ T+++ E
Sbjct: 2620 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2679
Query: 280 QNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEER 339
N E+ ++ A + + +++AE +++L+ E T Q+D+ + + +E+
Sbjct: 2680 FN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2738
Query: 340 ITTLEKRYLSAQRESTS---IHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKL 396
++ LEK + +ES + KL +A++ ++ N+ Q ++ A ++
Sbjct: 2739 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQI 2798
Query: 397 Q-QTMRKAETLPEVEAELAQRIAALTKAEERHGN--IEERMRHL 437
Q+ +E + E+ ++ ++I K +E H ++ RH+
Sbjct: 2799 NLQSECSSEEVTEIISQFTEKI---EKMQELHAAEILDMESRHI 2839
Score = 42.4 bits (98), Expect = 0.003
Identities = 126/657 (19%), Positives = 244/657 (37%), Gaps = 115/657 (17%)
Query: 63 LQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEE 122
LQD+ ++ L+ Q+ L I SL L ++ E L K L A E +
Sbjct: 1328 LQDL--EKTKLEEQVQE-LESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSL 1384
Query: 123 EISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFE 182
+ + ++ + + C+ + ++ + GV E ++K L+ ++
Sbjct: 1385 PVDSVVITESDAQRTMYPGSCVKKNIDGTIEFS-------GEFGVKEETNIVKLLEKQYQ 1437
Query: 183 HHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE-- 240
LEEE+A + Q + R E + S+
Sbjct: 1438 EQ--------------------LEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQA 1477
Query: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE 300
H + +E +LS I +T + V+++ KE LS +GE
Sbjct: 1478 HAVCQQEQHYFNEMKLSQDQIGF--QTFETVDVK------------FKEEFKPLSKELGE 1523
Query: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHD- 359
+E + D DI E+ + E + + +K ++ Q SIHD
Sbjct: 1524 HGKEILLSNSD-----------PHDIPESKDCVLTISEEMFSKDKTFIVRQ----SIHDE 1568
Query: 360 ----MNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQ 415
D + N+E + +E RQ QE + E Q MR+ E E + +L +
Sbjct: 1569 ISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQE 1628
Query: 416 RIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNE-EHNKRLS----DTVD 470
I L + + +I+ N+ L R+R + E E K+LS + +
Sbjct: 1629 EIKRLNRQLAQRSSID-------------NENLVSERERVLLEELEALKQLSLAGREKLC 1675
Query: 471 RLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELD 530
L S+ + Q + E +EE+ +E + +++ + ER A ++K + L
Sbjct: 1676 CELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYA--LQKANNRLL 1732
Query: 531 QLKM---RTGSLIEPTIPR---THLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMG 584
++ + +T + +E TI R LD S++ + S + S+++ +
Sbjct: 1733 KILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEH----- 1787
Query: 585 VRRDEPKVKSLGDHE--------WNRTQQIGV-LSSHPFESDTEMSDIDDDDRETIF--- 632
R + + S + W++ + G LS S ++ID ++ E +
Sbjct: 1788 TRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNIS 1847
Query: 633 ----SSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRV 685
++++ L + + L Q + + + R QE ES + + EE+ R+
Sbjct: 1848 SRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ-EELRERL 1903
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 102 bits (255), Expect = 2e-21
Identities = 216/1001 (21%), Positives = 403/1001 (40%), Gaps = 147/1001 (14%)
Query: 16 SQRGSQSSGSDSDSHFEQLMVNMLD-ERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQ 74
S S SD DS E L+ N +++L+ LR + SLS + + +++ LQ
Sbjct: 109 SSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQ 168
Query: 75 RQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNT 134
R+ + L G L+ S+ A L +EL ++ +EE E++
Sbjct: 169 REK--------KKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQY 220
Query: 135 RLLLEHLECLVSRHERSLRMT---------------VVKRQAQSPSGVSSEVEVLKALKS 179
+L+ L+ + R+ M V ++ S VE ++K+
Sbjct: 221 ISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT 280
Query: 180 LFEHHKALDEKVRER---LRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGS 236
L + L ++V+ + L+ E + + +E+ E AL+EQ + ++ E
Sbjct: 281 L----ETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQ---LDERLQELE-- 331
Query: 237 TESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIV------ELQELLEKQNYEMAQMKER 290
+ + L E + + + R + I+ ++ +V ++ E LE + E+AQ++ R
Sbjct: 332 -KIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390
Query: 291 LAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQ-KEDMEERITTLEK---- 345
+ ++++ E+ ++ E + + + E + EA + K +M+E+I T+EK
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE 450
Query: 346 RYLSAQRE----------------STSIHDMNDKLENELANKE-AILRQMEEKNRQLQER 388
+S Q+E I + E ELA KE + ++++ + R+ QE+
Sbjct: 451 ERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQ 510
Query: 389 LELAEQKLQ-------QTMRKAETLPEVEAELAQRIAALTKAEERHGNIEE-------RM 434
+++A +K Q Q + E+L E EL Q+ A LT++E + ++++ R+
Sbjct: 511 MKVALEKSQSEYLKISQEKEQQESLALEELEL-QKKAILTESENKLRDLQQEAETYRTRI 569
Query: 435 RHLEGQLEE-----KNQELQRARQREKMNEEHNKRLSDTV--------------DRLLTE 475
LE LE+ KNQ A E +HNK ++ V D L TE
Sbjct: 570 LELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTE 629
Query: 476 SNERLQLHLKERMAALEEKNVLIQESETFRKNLE--ESLHDKERLAEEIEKLRSELDQLK 533
+ L+ + M L EK QE ET K+ E H +E + +EKL + +L+
Sbjct: 630 KLQVLKQQYQTEMEKLREK--CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELE 687
Query: 534 MRTGSLIEPTIPRTHL--------DTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGV 585
+ L E R L D + +++ + + +D Q ++ +V + + +
Sbjct: 688 SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSI 747
Query: 586 RRDEPKVK-SLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHS 644
+R E +K + E ++ L H + +DI + E +S L +
Sbjct: 748 QRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQ 807
Query: 645 DA---------QTLAMMLQEQLD------AINKEIRLIQEEKES--TELRAEEIENRVAS 687
A + LA + Q+ LD + K++ ++ +K+ TEL A +I+ +
Sbjct: 808 SATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLM 867
Query: 688 VSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRS----PAREMDRMGVMT 743
LE N S+T V S L + + L + RE + +
Sbjct: 868 QQLEKQNSEMEQKVKSLT-QVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEI 926
Query: 744 LPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRALRMTHTLPSSYHNDARSSLSVS 803
L L I ++ E+ E K + + +A M TL D + L
Sbjct: 927 LTQKLSAKEDSIHILNEE-YETKFKNQEKKMEKVKQKAKEMQETLKKKL-LDQEAKLKKE 984
Query: 804 LEPESLGLGSA----NSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETEAAA 859
LE +L L N+ + +A GI ++ RL +K ++ L E
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQA-NSAGISDAVSRL-ETNQKEQIESLTEVHRRELND 1042
Query: 860 QESLGLGKLGTQAEK-----DRRLKKKHELLEEARRKGLPF 895
S+ KL QAE+ + +L++K + + E ++K L F
Sbjct: 1043 VISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
Score = 88.2 bits (217), Expect = 4e-17
Identities = 124/576 (21%), Positives = 253/576 (43%), Gaps = 84/576 (14%)
Query: 25 SDSDSHFEQLMVNMLDERDRLLDTLRETQ-----ESLSLAQQRLQDVI--------YDRD 71
++ + H +++ V M+++ L++L+ Q E L + +Q+ Q + +++
Sbjct: 596 AEKNKHNKEITV-MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKE 654
Query: 72 SLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAER 131
+L + IE + E +L+ EL+ + + EEE+S LK +
Sbjct: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714
Query: 132 NNTRLLLE------------HLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKS 179
+ + LE ++ ++ HE S++ T + Q +++E+L LK
Sbjct: 715 DKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQI-----NQLELL--LKE 767
Query: 180 LFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTES 239
+H K V E L ++R S E + A+A ++ + H Q K + +
Sbjct: 768 RDKHLKEHQAHV-ENLEADIKR-SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQ 825
Query: 240 EHLEGMEPGQKVHEKRLSNGSIDSTDETS-------QIVELQELLEKQNYEMAQMKERLA 292
+ L +E + + K+++ D + Q+ +L + LEKQN EM Q + L
Sbjct: 826 QKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLT 885
Query: 293 AL-SSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQ 351
+ S++ + +E E ++ L++ E M + +E ++ I L ++ LSA+
Sbjct: 886 QVYESKLEDGNKEQEQTKQILVEKENM----------ILQMREGQKKEIEILTQK-LSAK 934
Query: 352 RESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEA 411
+S IH +N++ E + N+E + ++++K +++QE L+ ++ L Q + + L
Sbjct: 935 EDS--IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLK--KKLLDQEAKLKKELENTAL 990
Query: 412 ELAQR-----IAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLS 466
EL+Q+ L A+ I + + LE +E Q E + E H + L+
Sbjct: 991 ELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE---------QIESLTEVHRRELN 1041
Query: 467 DTV---DRLLTESNERL------QLHLKERMAALEEKNVLIQESETFRKNLEESLHDKER 517
D + ++ L + E L QL KE+ A ++ +L+ E N E + +E
Sbjct: 1042 DVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEG 1101
Query: 518 LAEE--IEKLRSELDQLKMRTGSLI-EPTIPRTHLD 550
+ ++ + +L+ +L Q SL + T + HL+
Sbjct: 1102 VKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137
Score = 78.6 bits (192), Expect = 4e-14
Identities = 132/648 (20%), Positives = 268/648 (41%), Gaps = 126/648 (19%)
Query: 39 LDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGA 98
+ E + L L E Q +L+++ Q + + + Q+ S + DIESL
Sbjct: 1271 VSELEAQLRQLTEEQNTLNIS---FQQATHQLEEKENQIKS-MKADIESLV--------- 1317
Query: 99 DPPEFAALTKELNACREQLLEKEEEISELKAER----NNTRLLLEHL-ECLVSRHERSLR 153
E AL KE ++ EKE I++LK E N L+ E L E V S +
Sbjct: 1318 --TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQ 1375
Query: 154 MTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAAN 213
+T + Q Q+ +S + + +L+ ++ K L++V L ++ +
Sbjct: 1376 LTDLNVQLQNSISLSEKEAAISSLRKQYDEEKC----------ELLDQVQDLSFKVDTLS 1425
Query: 214 QEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVEL 273
+E ++ EQ K + + +S + +++ + +L S ++ ++ QI L
Sbjct: 1426 KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL-QIQLELKSKEAYEKDEQINLL 1484
Query: 274 QELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQK 333
+E L++QN +K GE+E D K E+ + + +++ A+
Sbjct: 1485 KEELDQQNKRFDCLK----------GEMED-------DKSKMEKKESNLETELKSQTARI 1527
Query: 334 EDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAE 393
++E+ IT +++ I +N+ L+N K+ +++ +K LQ EL E
Sbjct: 1528 MELEDHIT----------QKTIEIESLNEVLKNYNQQKDIEHKELVQK---LQHFQELGE 1574
Query: 394 QKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQ 453
+K + + +AEE+ +E ++ ++ +LE K +EL+
Sbjct: 1575 EKDNR---------------------VKEAEEKILTLENQVYSMKAELETKKKELEHVNL 1613
Query: 454 REKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEK--NVLIQESETFRKNLEES 511
K EE K L D ++ L+ ++++AA++++ + + ++ E ++K E
Sbjct: 1614 SVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESH 1673
Query: 512 LHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRT 571
L + +E E+ H+ L + S+ SQS+
Sbjct: 1674 LSELNTKLQERER---------------------EVHI-----LEEKLKSVESSQSE--- 1704
Query: 572 TKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETI 631
T ++ R + + ++ + S G + ++I VL + E + + + + ET+
Sbjct: 1705 TLIVPRSAK-NVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETV 1763
Query: 632 FSSMDL-------LSPSGHSDA-----QTLAMMLQEQLDAINKEIRLI 667
S ++ L H++A Q++ LQE+L+ NK+ LI
Sbjct: 1764 SSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLI 1811
Score = 72.4 bits (176), Expect = 3e-12
Identities = 127/667 (19%), Positives = 274/667 (41%), Gaps = 90/667 (13%)
Query: 60 QQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADP---PEFAALTKELNACREQ 116
Q++ + ++ +++++ Q+ ++IE LT L+ + + E+ K E+
Sbjct: 899 QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEK 958
Query: 117 LLEKEEEISE------------LKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP 164
+ +K +E+ E LK E NT L L S+ E+ +++ +
Sbjct: 959 VKQKAKEMQETLKKKLLDQEAKLKKELENTALEL-------SQKEKQFNAKMLEMAQANS 1011
Query: 165 SGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNV 224
+G+S V L+ + E ++L E R L + +S E++L +E+ + E +
Sbjct: 1012 AGISDAVSRLETNQK--EQIESLTEVHRRELN---DVISIWEKKLNQQAEELQEIHE--I 1064
Query: 225 HIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEM 284
+Q K E E E + +K L G + + +I L+E KQ+ +
Sbjct: 1065 QLQEK--------EQEVAE-------LKQKILLFGC-EKEEMNKEITWLKEEGVKQDTTL 1108
Query: 285 AQMKERLAALSSRVGEVEQEA-------ETARKDLIKTEEMNTKYQRDIREAMAQKEDME 337
+++E+L S+ V + Q+ E DL K+ + NT Q + E E+ +
Sbjct: 1109 NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDK 1168
Query: 338 ERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQ 397
+++ L + + E S+ ++K L +K +++ E +L +L++ +K +
Sbjct: 1169 RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSE---ELAIQLDICCKKTE 1225
Query: 398 QTMR-KAETLPEVEAELAQRIAA-LTKAEERHGNIEERM-------RHLEGQLEEKNQE- 447
+ K L + + I + ++ + R ++E + LE QL + +E
Sbjct: 1226 ALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQ 1285
Query: 448 ------LQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQES 501
Q+A + + E K + ++ L+TE + ++ AA E+++ + Q
Sbjct: 1286 NTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQ-- 1343
Query: 502 ETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGS 561
+K L E+++ + EE+++ + E+ L + L L S L +
Sbjct: 1344 --LKKELSENINAVTLMKEELKEKKVEISSLSKQLTDL------NVQLQNSISLSEKEAA 1395
Query: 562 LVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMS 621
+ + Y K + V+ KV +L + + +Q+ S+ E +
Sbjct: 1396 ISSLRKQYDEEKCELLDQ-----VQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQ 1450
Query: 622 DIDDDDRETIFS---SMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRA 678
+ T+ ++L S + + + + L+E+LD NK ++ E E + +
Sbjct: 1451 SRFTQHQNTVKELQIQLELKSKEAYEKDEQINL-LKEELDQQNKRFDCLKGEMEDDKSKM 1509
Query: 679 EEIENRV 685
E+ E+ +
Sbjct: 1510 EKKESNL 1516
Score = 72.0 bits (175), Expect = 3e-12
Identities = 141/685 (20%), Positives = 265/685 (38%), Gaps = 115/685 (16%)
Query: 34 LMVNMLDERDRLLDTLRETQES----LSLAQQRLQDVIYDRDSLQRQLNSALPQ---DIE 86
L+ LD++++ D L+ E + + L+ + + + +L + Q +IE
Sbjct: 1483 LLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIE 1542
Query: 87 SLTGGLAGSKGADPPEFAALTKELN--------------ACREQLLEKEEEISELKAERN 132
SL L E L ++L E++L E ++ +KAE
Sbjct: 1543 SLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELE 1602
Query: 133 NTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVS-----SEVEVLKALKSLFEHHKAL 187
+ LEH+ V E L+ + +++S + ++ +E ++ K L +
Sbjct: 1603 TKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEK 1662
Query: 188 DEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEP 247
+E+ ++ L ++ +E RE+ VHI + S S++SE L
Sbjct: 1663 EEQYKKGTESHLSELNTKLQE-----------REREVHILEEKLKSVESSQSETLIVPRS 1711
Query: 248 GQKV-----HEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVE 302
+ V E+ S G + T E V + L EK+ L RVG+ +
Sbjct: 1712 AKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEK------------LLQRVGQEK 1759
Query: 303 QEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMND 362
+E ++ EM +YQ ER+ LE + + I + +
Sbjct: 1760 EETVSSH------FEMRCQYQ--------------ERLIKLEHAEAKQHEDQSMIGHLQE 1799
Query: 363 KLENELANKEAILRQMEEK-----NRQLQERLELAEQKLQQTMRKAE-TLPEVEAELAQR 416
+LE + I+ Q EK N Q ++ LE +Q+T+++ E T +E ++ +
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859
Query: 417 IAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNE--EHN---KRLSDTVDR 471
+ L + +E H M L + EK Q LQ+ R K E E N K S V
Sbjct: 1860 DSCLVRQKEVH---RVEMEELTSKY-EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQP 1915
Query: 472 LLTESNERLQLHLKERMAALE-EKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELD 530
L + E L+ ++A E EK L +E +K+L + + +E+E L+ E D
Sbjct: 1916 KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ---QELEILKKEYD 1972
Query: 531 QLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEP 590
Q + + + H T +L T++ ++ + M ++
Sbjct: 1973 QEREEKIKQEQEDLELKHNSTLKQLMREF-----------NTQLAQKEQELEMTIKETIN 2021
Query: 591 KVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDI--DDDDRETIFSSMDLLSPSGHSDAQT 648
K + + + +L SH E++ + I DDD + + + + +
Sbjct: 2022 KAQEV---------EAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Query: 649 LAMMLQEQLDAINKEIRLIQEEKES 673
LQ QL+ + K+ + E++E+
Sbjct: 2073 KVRDLQTQLEELQKKYQQKLEQEEN 2097
Score = 69.3 bits (168), Expect = 2e-11
Identities = 116/523 (22%), Positives = 225/523 (43%), Gaps = 72/523 (13%)
Query: 27 SDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIE 86
++SH +L L ER+R + L E +S+ +Q + +I R + N A + E
Sbjct: 1670 TESHLSELNTK-LQEREREVHILEEKLKSVESSQS--ETLIVPRSAK----NVAAYTEQE 1722
Query: 87 SLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVS 146
A S+G + ++++ + L EKE+ + + E+ T + H E
Sbjct: 1723 E-----ADSQGCVQKTYE---EKISVLQRNLTEKEKLLQRVGQEKEET--VSSHFEMRCQ 1772
Query: 147 RHERSLRMT---VVKRQAQSPSG-VSSEVEVLKALKSLF--EHHKALDEKVRERLRVSLE 200
ER +++ + + QS G + E+E SL +H + K + + +LE
Sbjct: 1773 YQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLE 1832
Query: 201 RVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGS 260
V ++ + + EQ + +++ S + H ME +EK +
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKI---KELDSCLVRQKEVHRVEMEELTSKYEKLQALQQ 1889
Query: 261 IDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNT 320
+D ++ ++++E + EK + Q K L+ + ++ ++E + A ++ K +
Sbjct: 1890 MDGRNKPTELLE-ENTEEKSKSHLVQPK-LLSNMEAQHNDLEFKLAGAEREKQKLGKEIV 1947
Query: 321 KYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEE 380
+ Q+D+R M +KE +E + L+K Y +RE + D EL + + + M E
Sbjct: 1948 RLQKDLR--MLRKEHQQE-LEILKKEY-DQEREEKIKQEQEDL---ELKHNSTLKQLMRE 2000
Query: 381 KNRQLQERLELAEQKLQQTMRKAETLPEVEAEL---------------AQRIAALTKAEE 425
N QL ++ + E +++T+ KA+ EVEAEL A++ L + +
Sbjct: 2001 FNTQLAQKEQELEMTIKETINKAQ---EVEAELLESHQEETNQLLKKIAEKDDDLKRTAK 2057
Query: 426 RHGNI----EERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQ 481
R+ I EE M L+ + +ELQ+ Q++ EE+ + T+ L T+
Sbjct: 2058 RYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQ------ 2111
Query: 482 LHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEK 524
L +K LI +S+ + E +H+ E ++ EK
Sbjct: 2112 ---------LAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 51.6 bits (122), Expect = 5e-06
Identities = 118/634 (18%), Positives = 250/634 (39%), Gaps = 104/634 (16%)
Query: 219 LREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSI--DSTDETSQIVELQEL 276
+ E+ +Q+ +A ++ S+ S M ++L G+ +S D S +LQ
Sbjct: 9 ISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLR 68
Query: 277 LE----------KQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDI 326
+ K++ + KE L SSR + +++ +M+++ + +
Sbjct: 69 VPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLV 128
Query: 327 REAMA-QKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQL 385
+ + KE + +R+ +E+ S + + + + L+ E + IL Q ++K+ L
Sbjct: 129 GNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKS--L 186
Query: 386 QERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRH--------- 436
+ EL E+ K E +A L ++ ++ + + +++R+R+
Sbjct: 187 RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLK 246
Query: 437 ----LEGQLE----EKNQE---------------LQRARQREKMNEEHNKRLSDTV---- 469
LE Q E E+N E L+ +QR K E KR +T+
Sbjct: 247 PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHK 306
Query: 470 ----------DRLLTESNERLQ-------LHLKER---MAALEEKNVLIQESE------- 502
+ L + +ERLQ LH+ E+ + L + LI++ E
Sbjct: 307 EQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVI 366
Query: 503 -TFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGS 561
++ + E+L KE EEI +LRS + Q+ + G + ++ EL ++ +
Sbjct: 367 AETKRQMHETLEMKE---EEIAQLRSRIKQMTTQ-GEELREQKEKSERAAFEELEKALST 422
Query: 562 LVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMS 621
++ R K + + +E ++ + + + + V+ E ++
Sbjct: 423 AQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQ 482
Query: 622 DIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLD-AINKE----IRLIQEEKESTEL 676
+ ++E +L QT QEQ+ A+ K +++ QE+++ L
Sbjct: 483 KL--HEKELARKEQELT-----KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESL 535
Query: 677 RAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREM 736
EE+E + ++ E N R + T L SS S ++ ++++
Sbjct: 536 ALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQEN-----KNQSKDL 590
Query: 737 DRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIK 770
+ L ++ KH ++I V+ E + + ++K
Sbjct: 591 ----AVHLEAEKNKHNKEITVMVEKHKTELESLK 620
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 102 bits (255), Expect = 2e-21
Identities = 120/558 (21%), Positives = 243/558 (43%), Gaps = 79/558 (14%)
Query: 13 TPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDS 72
T S+ + G++ + + ++L+++ +L + E Q L L + Q++ +R+
Sbjct: 587 TLKSRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERER 646
Query: 73 LQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERN 132
++ L Q E + E + L + L +L + EE+ ++K ER
Sbjct: 647 MRANLEELRSQHNEKVE------------ENSTLQQRLEESEGELRKNLEELFQVKMERE 694
Query: 133 NTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVR 192
+ + L+ +S L + + + ++ + L+ L + ++ +R
Sbjct: 695 QHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLR 754
Query: 193 ERLRVSLERVSALEEELAAANQEIVALREQ-NVHIQRKMASSEGSTESEHLEGMEPGQKV 251
+R R AL+EE+++ +QE+ L+EQ + +Q S E +T++ +V
Sbjct: 755 KRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV---------EV 805
Query: 252 HEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKD 311
R + D ++ LQE EK ++ R L RV +++++ E + D
Sbjct: 806 LASRSNTSEQDQAGTEMRVKLLQEENEK-------LQGRSEELERRVAQLQRQIEDLKGD 858
Query: 312 LIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANK 371
K +E KY+ +IR+ LE+ + A++E LENEL
Sbjct: 859 EAKAKETLKKYEGEIRQ--------------LEEALVHARKEEKEAVSARRALENELEAA 904
Query: 372 EAILRQMEEKNRQLQERL-ELAEQKLQQTMRKAE----------TLPEVEAELAQRI-AA 419
+ L Q ++ +QL E+L E +EQK Q K E T+ +++ E+A + A+
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
Query: 420 LTKAEERHGNIEE-------RMRHLEGQLEEKNQELQRAR--------QREKMNEE--HN 462
T E ++E + ++ QL+EK E +++R + M EE
Sbjct: 965 RTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDY 1024
Query: 463 KRLSD---TVDRLLTESNERLQLHLKERMAALEEKNVLIQESE----TFRKNLEESLHDK 515
+R D T +LL ++ + L+ L+ + ++++ L+++ E LEE ++
Sbjct: 1025 QRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNS 1084
Query: 516 ERLAEEIEKLRSELDQLK 533
+ L+E I + R +++QL+
Sbjct: 1085 DLLSERISRSREQMEQLR 1102
Score = 101 bits (251), Expect = 5e-21
Identities = 147/648 (22%), Positives = 266/648 (41%), Gaps = 98/648 (15%)
Query: 9 INEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLS----------- 57
+ E++ + QR +S G + E V M ER++ +R+ Q+ LS
Sbjct: 662 VEENSTLQQRLEESEGELRKNLEELFQVKM--EREQHQTEIRDLQDQLSEMHDELDSAKR 719
Query: 58 --------------LAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEF 103
A+Q LQD++ ++ Q L +++ +L G L + E
Sbjct: 720 SEDREKGALIEELLQAKQDLQDLLIAKEE-QEDLLRKRERELTALKGALKEEVSSHDQEM 778
Query: 104 AALTKELNACREQLLEKEEEIS---ELKAERNNT------------RLLLEHLECLVSRH 148
L ++ +A + L E EE + E+ A R+NT +LL E E L R
Sbjct: 779 DKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRS 838
Query: 149 ERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSA---L 205
E L V + Q Q E + + LK + L+E + + E VSA L
Sbjct: 839 EE-LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRAL 897
Query: 206 EEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEP---------GQKVHEKRL 256
E EL AA + ++ + K+ E S + E L ++ G+ + + +
Sbjct: 898 ENELEAAQGNLSQTTQEQKQLSEKL--KEESEQKEQLRRLKNEMENERWHLGKTIEKLQK 955
Query: 257 SNGSIDSTDETSQIV---ELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARK--- 310
I TS + +L E EK E+A+M+ +L + E E+ TA K
Sbjct: 956 EMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQL---KEKTLEAEKSRLTAMKMQD 1012
Query: 311 DLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELAN 370
++ EE YQR EA+ +++ +E+ + LE + + ++E++++
Sbjct: 1013 EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQ 1072
Query: 371 KEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNI 430
E L + + L ER+ + ++++Q + E L E A ++ E ++ ++
Sbjct: 1073 LEMELEEERNNSDLLSERISRSREQMEQL--RNELLQERAARQDLECDKIS-LERQNKDL 1129
Query: 431 EERMRHLEG-----------QLEEKNQELQ---RARQREKMNEE-HNKRLSDTVDRL--- 472
+ R+ HLEG Q+E + EL+ + +R++ N + N+RL V L
Sbjct: 1130 KSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQ 1189
Query: 473 -------LTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKL 525
LT+ ++L L LK +EE I E+ +K L+ L ++ + E L
Sbjct: 1190 VDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEH---L 1246
Query: 526 RSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTK 573
+ +L+ +K P+ +D +L GSL ++ Y +K
Sbjct: 1247 QGQLNSMKKDLRLKKLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSK 1294
Score = 50.8 bits (120), Expect = 8e-06
Identities = 68/304 (22%), Positives = 131/304 (43%), Gaps = 43/304 (14%)
Query: 399 TMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQ------ELQRAR 452
T RK + E L R A + + N ++ L LE+K++ ELQR
Sbjct: 574 TKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEVKDL---LEQKSKLTIEVAELQRQL 630
Query: 453 QREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESL 512
Q E N+++ K E ER++ +L+E + EK ++E+ T ++ LEES
Sbjct: 631 QLEVKNQQNIK-----------EERERMRANLEELRSQHNEK---VEENSTLQQRLEESE 676
Query: 513 HDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYS-------VGSLVDS 565
+ + EE+ +++ E +Q + L + + H + + R + L+ +
Sbjct: 677 GELRKNLEELFQVKMEREQHQTEIRDL-QDQLSEMHDELDSAKRSEDREKGALIEELLQA 735
Query: 566 QSDYRTTKVIRRPRRGRMGVR-RDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDID 624
+ D + + + + + R R+ +K E +SSH E D ++ +
Sbjct: 736 KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEE---------VSSHDQEMD-KLKEQY 785
Query: 625 DDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENR 684
D + + + S++ + + A Q+Q ++L+QEE E + R+EE+E R
Sbjct: 786 DAELQALRESVEEATKNVEVLASRSNTSEQDQAGT-EMRVKLLQEENEKLQGRSEELERR 844
Query: 685 VASV 688
VA +
Sbjct: 845 VAQL 848
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 100 bits (250), Expect = 7e-21
Identities = 117/534 (21%), Positives = 236/534 (44%), Gaps = 44/534 (8%)
Query: 13 TPMSQRGSQSSGSDSDSHFEQLMVNMLDER----DRLLDTLRETQESLSLAQQRLQDVIY 68
T +++ +S + + M+ L+ER ++ L +T+ L L D I
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 69 DRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELK 128
+ + +L L + E L LA + + AL K++ Q+ E +E++ +
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL-KKIRELESQISELQEDLESER 1124
Query: 129 AERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHH 184
A RN R L E LE L + E +L T +++ +S EV +LK K+L E
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR--EQEVNILK--KTLEEEA 1180
Query: 185 KALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEG 244
K + +++E + + V L E+L EQ ++ + ++ + E+E
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQL-----------EQTKRVKANLEKAKQTLENER--- 1226
Query: 245 MEPGQKVHE-KRLSNGSIDSTDETSQI-VELQELLEKQNYEMAQMKERLAALSSRVGEVE 302
G+ +E K L G DS + ++ +LQEL K N E +++ LA +V +++
Sbjct: 1227 ---GELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN-EGERVRTELA---DKVTKLQ 1279
Query: 303 QEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMND 362
E + L +++ ++K +D +Q +D +E + ++ LS + + D +
Sbjct: 1280 VELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN 1339
Query: 363 KLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTK 422
+L +E +E++ L ++ ++K++ ++ ET EV+ +L + + L++
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399
Query: 423 AEER----HGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNE 478
E + +E+ L+ +L++ +L RQ E+ K+ D+LL E
Sbjct: 1400 RHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF----DQLLAEEKT 1455
Query: 479 RLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQL 532
+ +ER A E ++ + + LEE++ K L ++ R+E++ L
Sbjct: 1456 ISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDL 1509
Score = 97.8 bits (242), Expect = 6e-20
Identities = 127/515 (24%), Positives = 216/515 (41%), Gaps = 93/515 (18%)
Query: 102 EFAALTKELNACREQLLEKEEEISEL--KAERNNTRLLLEHLECLVSRHERSLRMTVVKR 159
E L +L A + QL E+ + +EL +AE RL + E H+ R+ +
Sbjct: 870 EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEE 929
Query: 160 QAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVAL 219
+ Q + E K +++ E + L+E+ R ++ LE+V+ E +L +E + L
Sbjct: 930 RCQH-----LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTT-EAKLKKLEEEQIIL 983
Query: 220 REQNVHIQRK--------------MASSEGSTES----------------EHLEGMEPGQ 249
+QN + ++ + E ++S E L E +
Sbjct: 984 EDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQR 1043
Query: 250 KVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETAR 309
+ EK DSTD + QI ELQ + + ++A+ +E L A +RV E + A
Sbjct: 1044 QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL 1103
Query: 310 KDLIKTEEMNTKYQRDIREAMA-------QKEDMEERITTLEKRY------LSAQRESTS 356
K + + E ++ Q D+ A QK D+ E + L+ +AQ+E S
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRS 1163
Query: 357 -----IHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMR-------KAE 404
++ + LE E EA +++M +K+ Q E ELAEQ L+QT R +
Sbjct: 1164 KREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE--ELAEQ-LEQTKRVKANLEKAKQ 1220
Query: 405 TLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEE---KNQELQRAR--------- 452
TL ELA + L + + G+ E + + +E QL+E K E +R R
Sbjct: 1221 TLENERGELANEVKVLLQGK---GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTK 1277
Query: 453 -QREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKN-----------VLIQE 500
Q E N SD+ LT+ L+ L++ L+E+N + E
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDE 1337
Query: 501 SETFRKNLEESLHDKERLAEEIEKLRSELDQLKMR 535
+FR+ LEE K L ++I L +++ +K +
Sbjct: 1338 KNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Score = 89.4 bits (220), Expect = 2e-17
Identities = 127/556 (22%), Positives = 237/556 (42%), Gaps = 115/556 (20%)
Query: 199 LERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSN 258
L +VS EEE+ A +E+V +RE +++A+ TE E L+ +K+
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVRE------KQLAAENRLTEMETLQSQLMAEKL------- 883
Query: 259 GSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQ---------EAETAR 309
+LQE L+ + A+ +E A L+++ E+E+ E E R
Sbjct: 884 -------------QLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEER 930
Query: 310 KDLIKTEEMNTKYQRDIREAMAQKEDME--------ERITTLEKRYLSAQRESTSIHDMN 361
++ E+ K Q++I+E Q E+ E E++TT E + + E + D N
Sbjct: 931 CQHLQAEK--KKMQQNIQELEEQLEEEESARQKLQLEKVTT-EAKLKKLEEEQIILEDQN 987
Query: 362 DK-------LENELANKEAILRQMEEKNR--------------QLQERL---ELAEQKLQ 397
K LE+ +A L + EEK++ L+ERL E Q+L+
Sbjct: 988 CKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELE 1047
Query: 398 QTMRKAE--------TLPEVEAELAQRIAALTKAEER----HGNIEE----------RMR 435
+T RK E + E++A++A+ L K EE +EE ++R
Sbjct: 1048 KTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR 1107
Query: 436 HLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL-------QLHLKERM 488
LE Q+ E ++L+ R E+ + L + ++ L TE + L +L K
Sbjct: 1108 ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQ 1167
Query: 489 AALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTH 548
K L +E++T ++E +++ ++ +E+L +L+Q K +L +T
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEM---RQKHSQAVEELAEQLEQTKRVKANL--EKAKQTL 1222
Query: 549 LDTSAELRYSVGSLVDSQ--SDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQI 606
+ EL V L+ + S+++ KV + + ++ E L D ++
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 607 GVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRL 666
++ +SD++ S + D FS+++ S D Q L Q +++ +++
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKD-----FSALE----SQLQDTQELLQEENRQKLSLSTKLKQ 1333
Query: 667 IQEEKESTELRAEEIE 682
+++EK S + EE E
Sbjct: 1334 VEDEKNSFREQLEEEE 1349
Score = 85.5 bits (210), Expect = 3e-16
Identities = 159/800 (19%), Positives = 311/800 (38%), Gaps = 139/800 (17%)
Query: 4 EVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRL 63
E + T EDT S Q S + L + +E ++E ++ S A + L
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201
Query: 64 QDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEE 123
+ + ++ L A Q +E+ G LA E L + + + E +
Sbjct: 1202 AEQLEQTKRVKANLEKA-KQTLENERGELAN-------EVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 124 ISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKS-LFE 182
+ EL+ + N + L V++ + L V +QS S S + AL+S L +
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELD-NVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 183 HHKALDEKVRERLRVSLE-----------RVSALEEELAAANQE--IVALREQNVHIQRK 229
+ L E+ R++L +S + R EEE A N E I L Q +++K
Sbjct: 1313 TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKK 1372
Query: 230 MASSEGSTES---------EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELL--- 277
M S G E+ + LEG+ Q+ EK + ++ T Q EL +LL
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLS--QRHEEKVAAYDKLEKTKTRLQ-QELDDLLVDL 1429
Query: 278 ----------EKQNYEMAQMKERLAALSSRVGEVEQEAET------------------AR 309
EK+ + Q+ +S++ E AE A
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAM 1489
Query: 310 KDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENEL- 368
+ + E +N +++ ++ + M+ K+D+ + + LEK + +++ + ++LE+EL
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQ 1549
Query: 369 ANKEAILR-------QMEEKNRQLQERLELAEQKLQQTMRKAETLP-EVEAELAQRIAAL 420
A ++A LR + R LQ R E +E+K +Q +R+ + E+E E QR A+
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 421 TKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTV---DRLLTESN 477
++ ++++ H++ + +++ +++ R+ + ++ + L DT + +L ++
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAK 1669
Query: 478 ERLQ---------LHLKERMAA-----------------------------LEEKNVLIQ 499
E + + L+E +AA LEEK L
Sbjct: 1670 ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEA 1729
Query: 500 ESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSV 559
+ LEE + E + + ++K ++DQ+ + + R+H + R +
Sbjct: 1730 RIAQLEEELEEEQGNTELINDRLKKANLQIDQIN------TDLNLERSHAQKNENARQQL 1783
Query: 560 GSLVDSQSDYRTTKVIRRPRRG------RMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHP 613
+ + KV + G + + E K+ L + N T++
Sbjct: 1784 ------ERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 614 FESDTEMSDI---DDDDRETIFSSMDLLSPSGHSDAQTLAMM--LQEQLDAINKEIRLIQ 668
++ ++ D+ DD+R D + Q + +E+ N R +Q
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 669 EEKESTELRAEEIENRVASV 688
E E A+ + V+S+
Sbjct: 1898 RELEDATETADAMNREVSSL 1917
Score = 77.8 bits (190), Expect = 6e-14
Identities = 102/504 (20%), Positives = 212/504 (42%), Gaps = 63/504 (12%)
Query: 17 QRGSQSSGSDSDSHFEQLMVN-------MLDERDRLLDTLRETQ-ESLSLAQQRLQDVIY 68
QR S + F+QL+ +ERDR RE + ++LSLA+ L++ +
Sbjct: 1432 QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA-LEEAME 1490
Query: 69 DRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELK 128
+ L+R LN ++E L SK L K A +Q+ E + ++ EL+
Sbjct: 1491 QKAELER-LNKQFRTEMEDLMS----SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 129 AERNNT---RLLLE-HLECLVSRHERSLR---------------------MTVVKRQAQS 163
E T +L LE +L+ + ++ ER L+ + + Q
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 164 PSGVSSEVEVLKALKSLFEH----HKALDEKVRERLRVSLERVSALEE--ELAAANQEIV 217
V++ ++ LK L H +K DE +++ ++ + + E + A+ +EI+
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 218 ALREQN-----------VHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDE 266
A ++N + +Q ++A++E + E E ++ G++ ++
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS-GKGALALEEK 1724
Query: 267 T---SQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQ 323
++I +L+E LE++ + +RL + ++ ++ + R K E + +
Sbjct: 1725 RRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLE 1784
Query: 324 RDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNR 383
R +E + ++ME + + K ++A I + ++L+NE ++A +Q+ +
Sbjct: 1785 RQNKELKVKLQEMEGTVKSKYKASITALE--AKIAQLEEQLDNETKERQAACKQVRRTEK 1842
Query: 384 QLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEE 443
+L++ L + + + + + + L Q L +AEE R L+ +LE+
Sbjct: 1843 KLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902
Query: 444 KNQELQRARQREKMNEEHNKRLSD 467
E A RE + ++ R D
Sbjct: 1903 AT-ETADAMNREVSSLKNKLRRGD 1925
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/227 (24%), Positives = 105/227 (46%), Gaps = 27/227 (11%)
Query: 324 RDIREAMAQKEDM---EERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEE 380
+ + + Q+E+M EE + + ++ L+A+ T + + +L E + L+ E
Sbjct: 835 KPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETE 894
Query: 381 ---KNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHL 437
+ +L+ RL +Q+L++ E E E E Q + A K +++ ++ L
Sbjct: 895 LCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK------KMQQNIQEL 948
Query: 438 EGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLH---LKERMAAL--- 491
E QLEE+ Q+ Q EK+ E + + +L + N +L L++R+A
Sbjct: 949 EEQLEEEESARQKL-QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007
Query: 492 ----EEKN----VLIQESETFRKNLEESLHDKERLAEEIEKLRSELD 530
EEK+ L + E +LEE L +E+ +E+EK R +L+
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLE 1054
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 100 bits (248), Expect = 1e-20
Identities = 147/715 (20%), Positives = 312/715 (43%), Gaps = 114/715 (15%)
Query: 52 TQESLSLAQQRLQ------DVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAA 105
T+E L+Q+ ++ ++ + + L ++S L +E L + S+ + E A
Sbjct: 1815 TEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAI--SETSSQLEHAK 1872
Query: 106 LTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPS 165
+T + RE +K+E LK + L E L HE S + +
Sbjct: 1873 VT-QTELMRESFRQKQEATESLKCQEE----LRERL------HEESRAREQLAVELSKAE 1921
Query: 166 GVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVH 225
GV ++ K+LFE + +RL L S +EL A Q+I RE
Sbjct: 1922 GV---IDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSR 1978
Query: 226 IQRKMASSEGSTESEHLEGMEP-----------GQKVHE---KRLSNGSIDSTDETSQIV 271
+ M + G E + L+ E +KV + K++ ID ++ S+ +
Sbjct: 1979 QKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFI 2038
Query: 272 ELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMA 331
EL++ ++N E+ ++++ AL E++ E RK + + ++ +++RD+ +
Sbjct: 2039 ELEQ---EKNTELMDLRQQNQAL-------EKQLEKMRK-FLDEQAIDREHERDVFQQEI 2087
Query: 332 QKEDMEERITTL-----EKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQ 386
QK + + ++ E + ++ + + + DK L +KE + R ++E+N ++
Sbjct: 2088 QKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEI- 2146
Query: 387 ERLELAEQKLQQTM------------RK----AETLPEV--EAELAQRIAALTKAEERHG 428
E+LE ++L+Q + RK E PE+ E +L A+ + E+
Sbjct: 2147 EKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEIT 2206
Query: 429 NIEERMRHLEGQLEEKNQELQRAR-QREKMNEEHNKRLS--DTVDRLLTESNERLQLHLK 485
N+EE++ +LE KN+E+Q+ Q E +E RL + ++L + E+L L +K
Sbjct: 2207 NLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIK 2266
Query: 486 ERMA-ALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTI 544
E A + ++++VL + F + ++E + ++L E++ KL+ QLK+ T + +
Sbjct: 2267 ESDAMSTQDQHVLFGK---FAQIIQEKEVEIDQLNEQVTKLQ---QQLKITTDNKV---- 2316
Query: 545 PRTHLDTSAELRYSVGSLVDS-QSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRT 603
++ EL + + ++ SD K R E +++ L +
Sbjct: 2317 ----IEEKNELIRDLETQIECLMSDQECVK------------RNREEEIEQLNEVIEKLQ 2360
Query: 604 QQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKE 663
Q++ + + +S ++ +++ +D++ A+ LA L++Q++ N+E
Sbjct: 2361 QELANIGQKTSMNAHSLS----EEADSLKHQLDVVI------AEKLA--LEQQVETANEE 2408
Query: 664 IRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSP 718
+ ++ + T + ++ + S+ E ++ ++ + +V L+ P
Sbjct: 2409 MTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP 2463
Score = 88.6 bits (218), Expect = 3e-17
Identities = 147/714 (20%), Positives = 301/714 (42%), Gaps = 98/714 (13%)
Query: 26 DSDSHFEQLMVNMLDERDRLLDT----------LRETQESLSLAQQRLQDVIYD-RDSLQ 74
+ ++ E+L +++E + L+ L E QE + Q ++++ + +S Q
Sbjct: 326 EKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQ 385
Query: 75 RQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNT 134
++ S+ ++I+ L G + + + + T + + E + ++ +L+AE +
Sbjct: 386 KERQSS--EEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ---ETQRKLEQLRAELDEM 440
Query: 135 --RLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEV-------------LKALKS 179
+ +++ + L+ +H + + + + + + S + + L
Sbjct: 441 YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI 500
Query: 180 LFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTES 239
+ + EK++E L + LE AL+ +L +E+ REQ ++ +A E
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 240 EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNY----EMAQMKERLAALS 295
H + + I S E+ + +EL+ E NY EM + KE+ A L
Sbjct: 561 AH-------KSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLE-KEKNAVLD 612
Query: 296 SRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDME-ERITTLEKRYLSAQRES 354
E E E R L+ + E E KED+E E +EK +++
Sbjct: 613 RMAESQEAELERLRTQLLFSHE---------EELSKLKEDLEIEHRINIEKL-----KDN 658
Query: 355 TSIH--DMNDKLENELANKEAILRQMEEKN---RQLQERLELAEQK-LQQTM--RKAETL 406
IH D L+NE++ K + Q E+ N +Q Q LE+++ K LQQ++ K+E +
Sbjct: 659 LGIHYKQQIDGLQNEMSQKIETM-QFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEM 717
Query: 407 PEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLS 466
EL + I L + E+ G +E+ ++ L+ EL + +EK N+ K
Sbjct: 718 TLQINELQKEIEILRQEEKEKGTLEQEVQELQ-----LKTELLEKQMKEKENDLQEKFAQ 772
Query: 467 -DTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKL 525
+ + +L + + L+ LK +E+ ++ +S + ++S+ +KE IE L
Sbjct: 773 LEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDS--IKSKSKDSVWEKE-----IEIL 825
Query: 526 RSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGV 585
E + LK + L E + + + AE + V + + Q +Y ++
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEV-NYQELQEEYACLLKVKDDLEDSKNK 884
Query: 586 RRDEPKVKSLGDHEWNRTQQIGV----LSSHPFESDT-------EMSDIDDDDRETIFSS 634
+ E K K +E Q+I + S F+ D EM ++ + D +
Sbjct: 885 QELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEK 944
Query: 635 MDLLSPSGHSDAQTLAMMLQE------QLDAINKEIRLIQEEKESTELRAEEIE 682
+++ +Q L+ + ++ ++ +N+E++ +++EKE LR E+E
Sbjct: 945 LEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELE 998
Score = 84.7 bits (208), Expect = 5e-16
Identities = 146/741 (19%), Positives = 320/741 (43%), Gaps = 104/741 (14%)
Query: 12 DTPMSQRGSQSSGSDSDSHFEQLMVNM------LDERDRLLDTLRETQESLSLAQ-QRLQ 64
D S++G+Q DS +H E + + ++E +R L+ +R T + L Q Q +
Sbjct: 142 DDSYSEQGAQ----DSPTHLEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFE 197
Query: 65 DVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEI 124
I RD + QL + L Q K EF LT++ + Q + +
Sbjct: 198 AAIKQRDGIITQLTANLQQ--------ARREKDETMREFLELTEQSQKLQIQFQQLQASE 249
Query: 125 SELKAERNNTRLLLEHLECLVSRHERSLRMT--VVKRQAQSPSGVSSEVEVLKALKSLFE 182
+ + ++T L + + H++ L +++ + + ++ L+ ++E
Sbjct: 250 TLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYE 309
Query: 183 HHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHL 242
+ D+KV + ++ + EEL N +I+ ++ + ++ K+ +++
Sbjct: 310 MEQ--DKKVENSNKEEIQEKETIIEEL---NTKIIEEEKKTLELKDKLTTADKLLGELQE 364
Query: 243 EGMEPGQKVHEKRLS-----NGSIDSTDETSQIVELQELLEKQNYEMAQMK--------- 288
+ ++ Q++ +L S++E Q++ E L+K+N++ +Q +
Sbjct: 365 QIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQ 424
Query: 289 ---ERLAALSSRVGE------VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEER 339
+L L + + E V+ + E R+ + + EEM T+++ ++ A+ +
Sbjct: 425 ETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSN---- 480
Query: 340 ITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQ----MEEK---NRQLQERLELA 392
IT E + + + +I+++N KL++ + KE + + +EEK RQL++ +E
Sbjct: 481 ITVNEDQ---IKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEEL 537
Query: 393 EQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQ-ELQRA 451
+Q R +T+ E E++L + +L+ E+ I + +LE K++ E+
Sbjct: 538 SFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRK-ELELKHEAEVTNY 596
Query: 452 RQREKMNEEHNKRLSDTVDRLLTESNERLQLHL----KERMAALEEKNVLIQESETFRKN 507
+ + +M E+ + D + ERL+ L +E ++ L+E + +
Sbjct: 597 KIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLK 656
Query: 508 LEESLHDKER-------LAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVG 560
+H K++ ++++IE ++ E D L + LI L+ S +L+
Sbjct: 657 DNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLI--------LEIS-KLKDLQQ 707
Query: 561 SLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQ-QIGVLSSHPFESDTE 619
SLV+S+S+ T ++ + + + R E K K + E Q + +L E + +
Sbjct: 708 SLVNSKSEEMTLQI--NELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKEND 765
Query: 620 MSD----------IDDDDRETIFSSMDLLSPSGHSDAQT-LAMMLQEQLDAI-NKEIRLI 667
+ + I D+++T+ + + +P + L + + D++ KEI ++
Sbjct: 766 LQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEIL 825
Query: 668 QEEKESTELRA----EEIENR 684
EE E + + EEIE +
Sbjct: 826 IEENEDLKQQCIQLNEEIEKQ 846
Score = 66.6 bits (161), Expect = 1e-10
Identities = 149/726 (20%), Positives = 291/726 (40%), Gaps = 152/726 (20%)
Query: 37 NMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSK 96
N++ ER+R+L E + LSLA + S Q Q + ++E T
Sbjct: 1647 NLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT------- 1699
Query: 97 GADPPEFAALTKELNACREQL---LEKEEEISELKAERNNTRLLLEHLECLVSRHERSLR 153
KEL+ E + + E + KA ++LLE ++ + E R
Sbjct: 1700 --------FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 154 --MTVVKRQAQSPSGVS----SEVEVLKALKSLF--EHHKALDEKV-----RERLRVSLE 200
+ ++ R ++S S S SE E ++KS EH + DE + + R +
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEA--SVKSCVHEEHTRVTDESIPSYSGSDMPRNDIN 1809
Query: 201 RVSALEEELAAANQEIVA-------LREQNVHIQRKMAS-------------SEGSTESE 240
S + EE +Q +V + +N + ++S SE S++ E
Sbjct: 1810 MWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLE 1869
Query: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAA-LSSRVG 299
H KV + L S E ++ ++ QE L ++ +E ++ +E+LA LS G
Sbjct: 1870 HA-------KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEG 1922
Query: 300 EVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHD 359
++ A+ T ++R I+E D
Sbjct: 1923 VIDGYADE-----------KTLFERQIQEKT----------------------------D 1943
Query: 360 MNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKA-----ETLPEVEAELA 414
+ D+LE EL L+++E + +Q+QE EL ++ + +A + L E E +
Sbjct: 1944 IIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK 2003
Query: 415 QRIAALTKAEERHGNIEERMRHLEGQLEE-----------KNQELQRARQR----EKMNE 459
+++ +AE+ +++++++ LE +EE KN EL RQ+ EK E
Sbjct: 2004 EKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLE 2063
Query: 460 EHNKRLSD-TVDR-----LLTESNERLQLHLK----------------ERMAA-LEEKNV 496
+ K L + +DR + + ++L+ LK E++A L+EK
Sbjct: 2064 KMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTD 2123
Query: 497 LIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELR 556
E ++ L+ + ++ E++E EL+Q + + + R H + E +
Sbjct: 2124 KCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG-AVEAK 2182
Query: 557 YSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGV-LSSHPFE 615
+ V Q++ I R + + + + +++ QQ+ + L E
Sbjct: 2183 PELSLEVQLQAE---RDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKE 2239
Query: 616 SDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTE 675
S T + +++ +++ +F D + G + ++ AM Q+Q K ++IQE++ +
Sbjct: 2240 STTRLQELEQENK--LFK--DDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID 2295
Query: 676 LRAEEI 681
E++
Sbjct: 2296 QLNEQV 2301
Score = 65.1 bits (157), Expect = 4e-10
Identities = 112/556 (20%), Positives = 230/556 (41%), Gaps = 80/556 (14%)
Query: 20 SQSSGSDSDSH-FEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLN 78
++S SD + H +Q+ L+ER ++T+ ++ ++ Q + + +YD +
Sbjct: 2961 TESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFS 3020
Query: 79 SALPQDIESLTGGLAGSKGADPPEFAALTKELNA-----------CREQLLEKEEEISEL 127
+ + +L + AA EL A C EQ + +E+ E
Sbjct: 3021 DWRGELLLALQQVFLEERSV---LLAAFRTELTALGTTDAVGLLNCLEQRI--QEQGVEY 3075
Query: 128 KAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPS---GVSSEVEVLKALKSLFEHH 184
+A +ECL RSL + AQ + E E K + L E++
Sbjct: 3076 QAA----------MECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYN 3125
Query: 185 KALDEKVRERLRVSLE------RVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTE 238
+ +K + L + +E R + L+E+L++ + L+ SE +
Sbjct: 3126 --IQQKQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELK------------SELAQT 3171
Query: 239 SEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRV 298
LE Q H K L ++ D+T ++ L + L + + +++ L +++
Sbjct: 3172 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKL 3231
Query: 299 GEVEQEAETARKDLIKTEEMNTKYQRDIREAM---AQKEDMEERITTLEKRYLSAQREST 355
G E+ + +DL + ++ QR+++ + QK+ + E +E + + + +
Sbjct: 3232 GRSEERDKEELEDL--KFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLS 3289
Query: 356 SIHDMNDKLENELANKEAILRQME---EKNRQLQERLELAEQKLQQ--TMRKAETLPEVE 410
N +L+ L +++ +R+M ++ R+L +L+ ++ Q + + L E++
Sbjct: 3290 EEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQ 3349
Query: 411 AELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVD 470
+L EE+H I E + E + K LQ +Q EK + H K L T
Sbjct: 3350 KQL----------EEKHSRIVELLNETE---KYKLDSLQTRQQMEKDRQVHRKTL-QTEQ 3395
Query: 471 RLLTESNER---LQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRS 527
TE ++ LQ +++ LEEK + + + + L+ + + ++ E E+ R
Sbjct: 3396 EANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKR- 3454
Query: 528 ELDQLKMRTGSLIEPT 543
+ ++ +L EPT
Sbjct: 3455 --ESRRILYQNLNEPT 3468
Score = 64.7 bits (156), Expect = 5e-10
Identities = 102/495 (20%), Positives = 205/495 (41%), Gaps = 86/495 (17%)
Query: 102 EFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQA 161
E +++ +EQL ++ ++ELK+E T+L LE L ++H+ + + +
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELE--TTLKAQHKHLKELEAFRLEV 3196
Query: 162 QSPSG--------VSSEVEVLKALKSLFEHHKAL-------DEKVRERLRVSLERVSA-- 204
+ + ++SE + + L+ E KA D++ E L+ SLE
Sbjct: 3197 KDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRN 3256
Query: 205 ------LEEELAAANQEIVALREQNVHIQRKMASSEGST-------ESEHLEGMEPGQKV 251
LE++ N+ + Q + +++ +G ESE + E +
Sbjct: 3257 LQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTL 3316
Query: 252 HEKRLSNGSIDSTDETSQ----------IVELQELLEKQNYEMAQM-----KERLAALSS 296
+R + + S+D T Q + ELQ+ LE+++ + ++ K +L +L +
Sbjct: 3317 DRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
Query: 297 RVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTS 356
R ++E++ + RK L +E NT+ Q+ + E ++ ED++ R L +R+
Sbjct: 3377 RQ-QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQ--------RQLEEKRQQVY 3427
Query: 357 IHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAE---- 412
KL+ E + I+++ +++ + +E+ E + + L Q + + T
Sbjct: 3428 ------KLDLEGQRLQGIMQEFQKQELEREEKRE-SRRILYQNLNEPTTWSLTSDRTRNW 3480
Query: 413 -LAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQR------------EKMNE 459
L Q+I TK E + + E + G N EL+ RQ+ +K +E
Sbjct: 3481 VLQQKIEGETK-ESNYAKLIE----MNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASE 3535
Query: 460 EHNKRLSDTVDRLLTESN-ERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERL 518
+D D + + N + + L L++ E+ L+ S + E L L
Sbjct: 3536 RLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERLLRQNAEL 3595
Query: 519 AEEIEKLRSELDQLK 533
I +L E + L+
Sbjct: 3596 TGHISQLTEEKNDLR 3610
Score = 55.1 bits (131), Expect = 4e-07
Identities = 99/440 (22%), Positives = 194/440 (44%), Gaps = 72/440 (16%)
Query: 151 SLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEE-- 208
SL+ + K Q Q E EV + +S H++ + R L ++L++V E
Sbjct: 2993 SLKDLITKMQLQR------EAEVYDSSQS----HESFSDW-RGELLLALQQVFLEERSVL 3041
Query: 209 LAAANQEIVAL----------------REQNVHIQRKMASSEGS------TESEHLEGME 246
LAA E+ AL +EQ V Q M + + +E + L
Sbjct: 3042 LAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQM 3101
Query: 247 PGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAE 306
G+K+ KR +S + +++E ++++ +M +M+ L+++ R E++++
Sbjct: 3102 NGRKITLKREQ----ESEKPSQELLEYN--IQQKQSQMLEMQVELSSMKDRATELQEQLS 3155
Query: 307 TARKDL--IKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKL 364
+ + + +K+E TK + + AQ + ++E LE L + ++ +H +ND L
Sbjct: 3156 SEKMVVAELKSELAQTKLELETT-LKAQHKHLKE----LEAFRLEVKDKTDEVHLLNDTL 3210
Query: 365 ENELANKEAILRQMEEKNRQL-----QERLELAEQKLQQTMRKAETLPEVEAELAQRIAA 419
+E + +E++ +L +++ EL + K +K L ++ L Q+
Sbjct: 3211 ASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNL-QLNLLLEQQKQL 3269
Query: 420 LTKAEERHGNIEERMRHLEGQLEE---KNQELQRARQREKMNEEHNKRLSDTVDRLLTES 476
L +++++ IE + + QL E +N ELQ + EK+ + +S T+DR
Sbjct: 3270 LNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKV---RIREMSSTLDR----- 3318
Query: 477 NERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEI--EKLRSELDQLKM 534
ER +LH + + + ++ SE K L++ L +K E+ E + +LD L+
Sbjct: 3319 -ER-ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQT 3376
Query: 535 RTGSLIEPTIPRTHLDTSAE 554
R + + R L T E
Sbjct: 3377 RQQMEKDRQVHRKTLQTEQE 3396
Score = 48.9 bits (115), Expect = 3e-05
Identities = 65/344 (18%), Positives = 153/344 (44%), Gaps = 25/344 (7%)
Query: 109 ELNACREQLLEKEE----EISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQA--- 161
EL C +Q+ + +E E L+ + N + ++E E + + +++ V+ A
Sbjct: 2514 ELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVE--EKVAAALVSQIQLEAVQEYAKFC 2571
Query: 162 QSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALRE 221
Q +SSE E ++ ++ ++++ + R+S LE ++ + ++ +E
Sbjct: 2572 QDNQTISSEPE----RTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE 2627
Query: 222 QNVHIQRKMASSEGSTES--EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEK 279
Q ++ + E + LEG E Q+ EK+ S ++ T+++ E
Sbjct: 2628 QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGF 2687
Query: 280 QNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEER 339
N E+ ++ A + + +++AE +++L+ E T Q+D+ + + +E+
Sbjct: 2688 FN-ELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
Query: 340 ITTLEKRYLSAQRESTS---IHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKL 396
++ LEK + +ES + KL +A++ ++ N+ Q ++ A ++
Sbjct: 2747 LSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQI 2806
Query: 397 Q-QTMRKAETLPEVEAELAQRIAALTKAEERHGN--IEERMRHL 437
Q+ +E + E+ ++ ++I K +E H ++ RH+
Sbjct: 2807 NLQSECSSEEVTEIISQFTEKI---EKMQELHAAEILDMESRHI 2847
Score = 42.4 bits (98), Expect = 0.003
Identities = 126/657 (19%), Positives = 244/657 (37%), Gaps = 115/657 (17%)
Query: 63 LQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEE 122
LQD+ ++ L+ Q+ L I SL L ++ E L K L A E +
Sbjct: 1328 LQDL--EKTKLEEQVQE-LESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSL 1384
Query: 123 EISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFE 182
+ + ++ + + C+ + ++ + GV E ++K L+ ++
Sbjct: 1385 PVDSVVITESDAQRTMYPGSCVKKNIDGTIEFS-------GEFGVKEETNIVKLLEKQYQ 1437
Query: 183 HHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESE-- 240
LEEE+A + Q + R E + S+
Sbjct: 1438 EQ--------------------LEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQA 1477
Query: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE 300
H + +E +LS I +T + V+++ KE LS +GE
Sbjct: 1478 HAVCQQEQHYFNEMKLSQDQIGF--QTFETVDVK------------FKEEFKPLSKELGE 1523
Query: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHD- 359
+E + D DI E+ + E + + +K ++ Q SIHD
Sbjct: 1524 HGKEILLSNSD-----------PHDIPESKDCVLTISEEMFSKDKTFIVRQ----SIHDE 1568
Query: 360 ----MNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQ 415
D + N+E + +E RQ QE + E Q MR+ E E + +L +
Sbjct: 1569 ISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQE 1628
Query: 416 RIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNE-EHNKRLS----DTVD 470
I L + + +I+ N+ L R+R + E E K+LS + +
Sbjct: 1629 EIKRLNRQLAQRSSID-------------NENLVSERERVLLEELEALKQLSLAGREKLC 1675
Query: 471 RLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELD 530
L S+ + Q + E +EE+ +E + +++ + ER A ++K + L
Sbjct: 1676 CELRNSSTQTQ-NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYA--LQKANNRLL 1732
Query: 531 QLKM---RTGSLIEPTIPR---THLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMG 584
++ + +T + +E TI R LD S++ + S + S+++ +
Sbjct: 1733 KILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEH----- 1787
Query: 585 VRRDEPKVKSLGDHE--------WNRTQQIGV-LSSHPFESDTEMSDIDDDDRETIF--- 632
R + + S + W++ + G LS S ++ID ++ E +
Sbjct: 1788 TRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNIS 1847
Query: 633 ----SSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRV 685
++++ L + + L Q + + + R QE ES + + EE+ R+
Sbjct: 1848 SRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQ-EELRERL 1903
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 99.0 bits (245), Expect = 3e-20
Identities = 113/531 (21%), Positives = 247/531 (46%), Gaps = 44/531 (8%)
Query: 30 HFEQLMVNMLDERDR-LLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESL 88
++ Q V L+ R L+ L ++ + +Q L V + R + L ++ ++L
Sbjct: 208 YYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEE-LTKERDAL 266
Query: 89 TGGLAGSKGADPP---EFAALTKELNACREQLLEKEEEISELKAERNNTRLLL--EHLEC 143
+ L + D + A L ++L + E + + ELK + +LLL + L+
Sbjct: 267 SLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQA 326
Query: 144 LVSRHERSLRMTVVKRQAQSPSGV-------SSEVEVLKALKSLFEHHKAL---DEKVRE 193
+ L+ K QAQ E ++ + + + E + + +EK+RE
Sbjct: 327 EADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIRE 386
Query: 194 ---RLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQK 250
++R E++ EE + +++ E + KM E + + E +K
Sbjct: 387 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK 446
Query: 251 VHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARK 310
+HE+ + E +I E QE ++Q +M + +E++ ++ E E++ +
Sbjct: 447 MHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEE 505
Query: 311 DLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKL---ENE 367
+ + E++ + +R +E M ++E E+I E+ + R+ IH+ +K+ E +
Sbjct: 506 KIHEQEKIREEEKRQEQEEMWRQE---EKIREQEEIW----RQKEKIHEQEEKIRKQEEK 558
Query: 368 LANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERH 427
+ +E + EEK R+ +E++ E+K+++ + E + E E ++ ++ + EE+
Sbjct: 559 MWRQEEKMHDQEEKIREQEEKVWRQEEKIRE---QEEKIREQEEKIREQEEMTQEQEEKM 615
Query: 428 GNIEERMRHLEGQLEEKNQELQR----ARQREKMNEEHNKRLSDTVDRLLTESNERLQLH 483
G EE+M E +++E+ ++++R R++EK E +++ + + ++ E E++
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQ-EEMMQEQEEKM-WE 673
Query: 484 LKERMAALEEKNVLIQESETFRKNLEESLHDKE-RLAEEIEKLRSELDQLK 533
+E+M EEK +QE E + EE + ++E RL ++ EK++ + L+
Sbjct: 674 QEEKMCEQEEK---MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 82.4 bits (202), Expect = 2e-15
Identities = 70/353 (19%), Positives = 158/353 (44%), Gaps = 27/353 (7%)
Query: 115 EQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVL 174
E++ E+EE+I E + + ++ E + R E + K + Q E ++
Sbjct: 382 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIR 441
Query: 175 KALKSLFEHHKALD--------EKVRERLRVSLERVSAL--------EEELAAANQEIVA 218
+ + + E K + EK+RE+ + + +EE +E +
Sbjct: 442 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMW 501
Query: 219 LREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLE 278
+E+ +H Q K+ E E E + E +K+ E+ + + +I E +E +
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQEEMWRQE--EKIREQE------EIWRQKEKIHEQEEKIR 553
Query: 279 KQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEE 338
KQ +M + +E++ ++ E E++ + + + EE + + IRE ++ EE
Sbjct: 554 KQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE 613
Query: 339 RITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQ 398
++ E++ + + + + E ++ +E +R+ EEK R+ +E ++ E+K+ +
Sbjct: 614 KMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 673
Query: 399 TMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRA 451
+ E + E E ++ ++ + + EE+ E R+R E +++E + L+ A
Sbjct: 674 ---QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 98.6 bits (244), Expect = 3e-20
Identities = 161/697 (23%), Positives = 286/697 (41%), Gaps = 120/697 (17%)
Query: 107 TKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSG 166
T+E + +E L ++ E + E N + LL+ E L RH ++ ++ + + G
Sbjct: 400 TEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDL--RHGLETQVMELQNKLKHVQG 457
Query: 167 VSSEVEVLKALKSLFEHHKALDE------KVRERLRVSLERVSALE----EELAAANQEI 216
EVL LK L E + L+E +V E+LR+ ++AL+ EE+A+ +QE+
Sbjct: 458 PEPAKEVL--LKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV 515
Query: 217 VALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIV-ELQE 275
+R+Q ++ S +H QK+ L G +ETS+ Q
Sbjct: 516 EHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKM--SALVRGLQRELEETSEETGHWQS 573
Query: 276 LLEKQNYEMAQMKERLAALSSRVGEVEQE-------------------AETARKDLIKTE 316
+ +K ++ K+ L L E+E+E +T + +++K E
Sbjct: 574 MFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKE 633
Query: 317 EMNTKYQRDIREAMAQKEDME----ERITTLEKRYLSAQREST---SIHDMNDKLENEL- 368
+ T Q +++E A+++ E R LEK+ + E+ + + N +L+ L
Sbjct: 634 LLRT--QEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQ 691
Query: 369 ---------------------------ANKEAILRQMEEKNRQLQERLELAEQKLQQT-- 399
A E LR+ +E+N + + R+ EQ+L++T
Sbjct: 692 QLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRG 751
Query: 400 ---------MRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEE------- 443
R + L +EAE Q AL ++E G++ R LE +LEE
Sbjct: 752 LVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLAR 811
Query: 444 ---KNQELQRA-----RQRE-----KMNEEHNKRLSD-TVDRL---LTESNERLQLHLKE 486
+ Q L RA +QRE K E KRL D TVDRL L + E + L++
Sbjct: 812 LGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQ 871
Query: 487 RMAALEE-KNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMR-TGSLIEPTI 544
A LE+ K +E ++ ++ + E+ + + +L+ E+ +L+ S E
Sbjct: 872 LQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDT 931
Query: 545 PRTHLDTSAE----LRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPK--VKSLGDH 598
R + A+ L + SQ D + R+ DE K V+ L D
Sbjct: 932 ARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDR 991
Query: 599 EWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLD 658
Q+ L + + + D++ D + DL + S+ QL+
Sbjct: 992 VNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLE 1051
Query: 659 AINK--EIRLIQEEKESTELRA--EEIENRVASVSLE 691
+ N+ + RL EE+E T L++ ++E +V +S++
Sbjct: 1052 SQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQ 1088
Score = 69.3 bits (168), Expect = 2e-11
Identities = 102/484 (21%), Positives = 201/484 (41%), Gaps = 64/484 (13%)
Query: 48 TLRETQES--------LSLAQQ----------------RLQDVIYDRDSLQRQLNSALPQ 83
TLRETQE L L QQ RL+D + ++ ++QL AL
Sbjct: 724 TLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNA 783
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLEC 143
E G LA +K A A +E +L ++++ ++ E R +L +
Sbjct: 784 SQEE-EGSLAAAKRA----LEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKA 838
Query: 144 LVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVS 203
+ +R L TV + + + L+ L++ E +K EK R + + +
Sbjct: 839 ELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQLEDYK---EKARREVADAQRQAK 895
Query: 204 ALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVH--EKRLSNGSI 261
E + + L+++ +++ + +S+ ++ L+ Q++ E+ N
Sbjct: 896 DWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKR 955
Query: 262 DSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVG----EVEQ------EAETARKD 311
D Q+ L+E + + E+ + K + L+ RV +V+Q + +AR+D
Sbjct: 956 SQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQD 1015
Query: 312 LIKTEEMNTKYQRDIREAMAQKE----------DMEERITTLEKRYLSAQRESTSIHDMN 361
L + + +D++ +A E +E + L++R + +RE T + N
Sbjct: 1016 LECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTN 1075
Query: 362 DKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALT 421
KLE ++ + + +++L L + L++ + +AE E+E R A
Sbjct: 1076 RKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAE--EEIERLDGLRKKAQR 1133
Query: 422 KAEERH---GNIEERMRHLEGQLEEK--NQELQRARQREKM-NEEHNKRLSD--TVDRLL 473
+ EE+H ++ R++ LE K + A + E + ++E + D ++ LL
Sbjct: 1134 EVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLL 1193
Query: 474 TESN 477
TESN
Sbjct: 1194 TESN 1197
Score = 63.9 bits (154), Expect = 9e-10
Identities = 86/352 (24%), Positives = 157/352 (44%), Gaps = 44/352 (12%)
Query: 24 GSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQ 83
G DS +QL + D +++ + ++ AQ++ +D + + L S L
Sbjct: 862 GEDSKQALQQLQAQLEDYKEK-------ARREVADAQRQAKDWASEAEKTSGGL-SRLQD 913
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLEC 143
+I+ L L S+ + A L KEL A R Q LE+E E K +++ L+ LE
Sbjct: 914 EIQRLRQALQASQAER--DTARLDKELLAQRLQGLEQEAE--NKKRSQDDRARQLKGLEE 969
Query: 144 LVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVS 203
VSR E L + VE+L D R R +V R
Sbjct: 970 KVSRLETEL------------DEEKNTVELLT------------DRVNRGRDQVDQLRTE 1005
Query: 204 ALEEELAAANQEI--VALREQNVHIQRKMASSEGSTE-SEHLEGMEPGQKVHEKRLSNGS 260
++E A + E ++L QN ++ ++ASSEG + S L +E ++ ++RL
Sbjct: 1006 LMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEE 1065
Query: 261 IDST--DETSQIVE--LQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTE 316
+ T T++ +E ++EL + E + ++ LS RV ++++ + A +++ + +
Sbjct: 1066 REKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLD 1125
Query: 317 EMNTKYQRDIREAMAQKEDMEERITTLEK-RYLSAQRESTSIHDMNDKLENE 367
+ K QR++ E E ++ RI +LEK + A R + N+ L ++
Sbjct: 1126 GLRKKAQREVEEQHEVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSD 1177
Score = 59.3 bits (142), Expect = 2e-08
Identities = 117/591 (19%), Positives = 222/591 (37%), Gaps = 115/591 (19%)
Query: 188 DEKVRERLRVSLERVSALEEELAAANQEIVA---LREQNVHIQRKMASSEGSTESEHLEG 244
+ VR ++ + LE++ L + + + + L + +QRK+ E + +
Sbjct: 330 ETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKL-----DEEVKKRQK 384
Query: 245 MEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQ-------NYEMAQMKERL------ 291
+EP Q E++L ++T + LQELLE++ N E+ MK L
Sbjct: 385 LEPSQVGLERQLE-------EKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDL 437
Query: 292 -AALSSRVGEV----------EQEAETARKDLIKTEEM---------------------- 318
L ++V E+ E E KDL++T E+
Sbjct: 438 RHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLREREL 497
Query: 319 ---------------------NTKYQRD---IREAM-----------AQKEDMEERITTL 343
+YQRD +R +M A+++ M + L
Sbjct: 498 TALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGL 557
Query: 344 EKRYLSAQRESTSIHDMNDKLENEL-ANKEAILR---QMEEKNRQLQERLELAEQKLQQT 399
++ E+ M K + +L A K+ +L+ + EE +L E++E+ +++L+Q
Sbjct: 558 QRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQA 617
Query: 400 MRKAETLPEVEA---ELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREK 456
A +VE EL + L + + + E RH + +LE++ L+ R +
Sbjct: 618 RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677
Query: 457 MNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKE 516
EE N +L T+ +L + E K +M A E VL Q L E+ + +
Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEA----SKAKMVAEAEATVLGQRRAAVETTLRETQEEND 733
Query: 517 RLAEEIEKLRSELDQLK--MRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKV 574
I L +L + + + G +E + AE + +L SQ + +
Sbjct: 734 EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAA 793
Query: 575 IRRPRRGRM-----GVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRE 629
+R R+ G+ R + ++L +Q VL E + E + D +
Sbjct: 794 AKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELE-EQKRLLDRTVD 852
Query: 630 TIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEE 680
+ ++ + Q L L++ + +E+ Q + + AE+
Sbjct: 853 RLNKELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEK 903
Score = 45.8 bits (107), Expect = 3e-04
Identities = 111/620 (17%), Positives = 235/620 (37%), Gaps = 91/620 (14%)
Query: 315 TEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQREST-SIHDMNDKLENELANKEA 373
+ E T +R + + + + + +++ + ++ Q E T + ++ KL+ E+ ++
Sbjct: 326 SSESETSVRRKVSLVLEKMQPLV-MVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQK 384
Query: 374 ILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEER 433
+ RQL+E+ E + ++E
Sbjct: 385 LEPSQVGLERQLEEKTEECSR-----------------------------------LQEL 409
Query: 434 MRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEE 493
+ +G+ ++ N+ELQ ++ E+ L V LQ LK
Sbjct: 410 LERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQV--------MELQNKLKHVQGPEPA 461
Query: 494 KNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSA 553
K VL+++ R+ LEE L K+R+ E++ EL LK G+L E R
Sbjct: 462 KEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALK---GALKEEVASRDQEVEHV 518
Query: 554 ELRYSVG------SLVDSQSDYRTTKVIRRPRRGRM-GVRRDEPKVKSLGDHEW-----N 601
+Y S+ D+ D+ + R+ + G++R+ + H W
Sbjct: 519 RQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGH-WQSMFQK 577
Query: 602 RTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAM-MLQEQLDAI 660
+ + + E +++++ E I L + S T + +L+++L
Sbjct: 578 NKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRT 637
Query: 661 NKEIRLIQEEKESTEL----RAEEIENRVASVSLE---GLNLARVHPGTSITASVTASSL 713
+E++ +Q E++S E+ R E+E ++A + +E G L + T
Sbjct: 638 QEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDC 697
Query: 714 ASSSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATI---- 769
+S + + T R + + + RR+I +E+ +E + +
Sbjct: 698 EEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGE 757
Query: 770 -----------KCETSPPPTPRALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQ 818
+ E AL + S A+ +L LE GL Q
Sbjct: 758 AVEARLRDKLQRLEAEKQQLEEALNASQEEEGSL-AAAKRALEARLEEAQRGLARLGQEQ 816
Query: 819 DSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKD-RR 877
+L++A +++G + + R + KA L + + ++ + + L K+G +++ ++
Sbjct: 817 QTLNRALEEEGKQREVLR----RGKAELEEQKRLLD-RTVDRLNKELEKIGEDSKQALQQ 871
Query: 878 LKKKHELLEEARRKGLPFAQ 897
L+ + E +E R+ + AQ
Sbjct: 872 LQAQLEDYKEKARREVADAQ 891
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 96.3 bits (238), Expect = 2e-19
Identities = 141/699 (20%), Positives = 300/699 (42%), Gaps = 91/699 (13%)
Query: 24 GSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQ 83
G+ ++H +++ + ++L + L A + DVI S ++ Q
Sbjct: 532 GAREETHQKEIKA-LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLL-LEHLE 142
+E L + G + EFA L ++ R L+ + EI L+ ++++ R + +E
Sbjct: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHEIENLQNQQDSERAAHAKEME 647
Query: 143 CLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERV 202
L R+ M V+K + S + S+++ + + H E +L+ + +V
Sbjct: 648 AL-----RAKLMKVIKEKENSLEAIRSKLDKAE------DQHLVEMEDTLNKLQEAEIKV 696
Query: 203 SALEEELAAANQE----------IVALREQNVHIQR-KMASSEGSTESEHLEGMEPGQKV 251
LE A N++ + A E+ + + + ASSEG +E + L +
Sbjct: 697 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ---LEA 753
Query: 252 HEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKD 311
EK++ + I+ E+S+ + L+ + ++ ++E L+ +S +E+E + ++
Sbjct: 754 AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK 813
Query: 312 LIKTEEMNTKYQRDIREA---MAQKED-----------MEERITTLEKRYLSAQRESTSI 357
+ E QR ++E + QKE+ + E + +E ++ +
Sbjct: 814 FAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL 873
Query: 358 HDMNDKLENELA-------NKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPE-- 408
+KLEN++A + + L +M ++ R + +E + KL + A L +
Sbjct: 874 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 933
Query: 409 ----VEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQR-EKMNEE--- 460
V+AE +Q+ AA K EE +E ++ LE ++E + + Q + R E+ E
Sbjct: 934 EDMTVKAEQSQQEAA-KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 992
Query: 461 HNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAE 520
++ + + + L ++ ++L+ A EE + L+QE E RK +++ + AE
Sbjct: 993 KHEEILQNLQKTLLDTEDKLK-------GAREENSGLLQELEELRKQADKA--KAAQTAE 1043
Query: 521 EIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQ----SDYRTTKVIR 576
+ ++ ++ + K T + +E T T+A+L+ + +L ++ + +K +
Sbjct: 1044 DAMQIMEQMTKEKTETLASLEDT-----KQTNAKLQNELDTLKENNLKNVEELNKSKELL 1098
Query: 577 RPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMD 636
+M R E +++L ++QQ+ L E + ++++ R+ + S
Sbjct: 1099 TVENQKMEEFRKE--IETLKQAAAQKSQQLSALQ----EENVKLAEELGRSRDEVTSHQK 1152
Query: 637 LLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTE 675
L + Q L M +E +K I+ EEK S +
Sbjct: 1153 LEEERSVLNNQLLEMKKRE-----SKFIKDADEEKASLQ 1186
Score = 71.2 bits (173), Expect = 6e-12
Identities = 122/609 (20%), Positives = 243/609 (39%), Gaps = 88/609 (14%)
Query: 27 SDSHFEQLMVNMLDERDRLLDTLRETQE---SLSLAQQRLQDVIYDRDSLQRQLNSALPQ 83
++ + L + E + RE Q L+ Q+ L +V +++L+++L +
Sbjct: 754 AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK 813
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLEC 143
E+ E ++ + + +L +KEE+ + L ++ R L +E
Sbjct: 814 FAEA------------SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA 861
Query: 144 LV-SRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERV 202
+ ER ++ K + ++ ++ + +K ++ L K+ + LR+ V
Sbjct: 862 KFREKDEREEQLIKAKEKLEN--------DIAEIMKMSGDNSSQLT-KMNDELRLKERDV 912
Query: 203 SALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSID 262
L+ +L AN+ L++ + K S+ +H E +K E++LS+
Sbjct: 913 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 968
Query: 263 STDETSQIVELQELLEKQNYEM-AQMKERLAALSSRVGEVEQEAETARKD----LIKTEE 317
+Q EL+ E+ E + +E L L + + E + + AR++ L + EE
Sbjct: 969 METSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE 1028
Query: 318 MNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELAN-KEAILR 376
+ + Q D +A ED + + + K N KL+NEL KE L+
Sbjct: 1029 L--RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1086
Query: 377 QMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTK-----AEE------ 425
+EE N+ +E L + QK+++ ++ ETL + A+ +Q+++AL + AEE
Sbjct: 1087 NVEELNKS-KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
Query: 426 ---RHGNIEERMRHLEGQL--------------------------------EEKNQELQR 450
H +EE L QL EK+ EL++
Sbjct: 1146 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK 1205
Query: 451 ARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEE 510
R + N + T +++++L LK + L+ K Q S + +
Sbjct: 1206 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1265
Query: 511 SLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYR 570
+ D+ +I+ L S + L+ + L + + + A L + L + SD +
Sbjct: 1266 ADEDERAQESQIDFLNSVIVDLQRKNQDL----KMKVEMMSEAALNGNGDDLNNYDSDDQ 1321
Query: 571 TTKVIRRPR 579
+ ++PR
Sbjct: 1322 EKQSKKKPR 1330
Score = 62.0 bits (149), Expect = 3e-09
Identities = 115/517 (22%), Positives = 201/517 (38%), Gaps = 99/517 (19%)
Query: 112 ACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMT-------VVKRQAQS- 163
A +E L EK++ I +L AER+ R + V E+ L + V++ +A+
Sbjct: 352 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD 411
Query: 164 ------PSGVSSEVEVLKALKSLFEHHKALDEKVRER------LRVSL----ERVSALEE 207
+ +VE+L L+ + L +V E L V+ R+ LE+
Sbjct: 412 QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEK 471
Query: 208 ELAAANQEIVALR-------------------------EQNVHIQRKMASSEGSTESEHL 242
+LA QE+ LR ++ + + R E ++ EH
Sbjct: 472 DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF 531
Query: 243 EGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYE-MAQMKERL-AALSSRVGE 300
E + K L + + E + E K+N + +A K +L A++S
Sbjct: 532 GAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQA 591
Query: 301 VEQ---------EAETARKDLIKT--EEMNTKYQRDIR--------EAMAQKEDMEERIT 341
+E+ ETA +KT E+M YQ +I E A ++ME
Sbjct: 592 MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRA 651
Query: 342 TLEKRYLSAQRESTSIHDMNDKLENE-LANKEAILRQMEEKNRQLQERLELAEQKLQQTM 400
L K + +I DK E++ L E L +++E +++E LE+ + K +
Sbjct: 652 KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-LEVLQAKCNEQT 710
Query: 401 RKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLE-----------EKNQELQ 449
+ + +++ L + + M+ L QLE EKN E
Sbjct: 711 KVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESS 770
Query: 450 RARQREKMNEEHNKRLSDTVDRL-----LTESNERLQLHLKERMAALEEKNVLIQES--E 502
+A + + +L++ + L + E+ E+ LKE+ A E+ V +Q S E
Sbjct: 771 KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 830
Query: 503 TFRKNLEESLHDKER----LAEEIEKLRSELDQLKMR 535
T K LH KE L+ ++EKLR L ++ +
Sbjct: 831 TVNK-----LHQKEEQFNMLSSDLEKLRENLADMEAK 862
Score = 34.3 bits (77), Expect = 0.77
Identities = 39/188 (20%), Positives = 85/188 (45%), Gaps = 27/188 (14%)
Query: 359 DMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIA 418
+ + + +++ A+ ++EK + +++ L + + + + + E+E ELA
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA---- 393
Query: 419 ALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMN-----EEHNKRLSDTVDRLL 473
A + H ++ + LE ++++ + + A REK+ EE +++ D R+
Sbjct: 394 ---LARDGH---DQHVLELEAKMDQL-RTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
Query: 474 TESNERLQLHL-----KERMAALEEKNVL-IQESETFRKNLEES-----LHDKERLAEEI 522
ES + L + K R+ LE+ L +QE R+ LE + + L +EI
Sbjct: 447 EESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 506
Query: 523 EKLRSELD 530
L+ +L+
Sbjct: 507 SSLQEKLE 514
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 96.3 bits (238), Expect = 2e-19
Identities = 141/699 (20%), Positives = 300/699 (42%), Gaps = 91/699 (13%)
Query: 24 GSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQ 83
G+ ++H +++ + ++L + L A + DVI S ++ Q
Sbjct: 567 GAREETHQKEIKA-LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 625
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLL-LEHLE 142
+E L + G + EFA L ++ R L+ + EI L+ ++++ R + +E
Sbjct: 626 AMEELKVSFSKGLGTETAEFAELKTQIEKMR---LDYQHEIENLQNQQDSERAAHAKEME 682
Query: 143 CLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERV 202
L R+ M V+K + S + S+++ + + H E +L+ + +V
Sbjct: 683 AL-----RAKLMKVIKEKENSLEAIRSKLDKAE------DQHLVEMEDTLNKLQEAEIKV 731
Query: 203 SALEEELAAANQE----------IVALREQNVHIQR-KMASSEGSTESEHLEGMEPGQKV 251
LE A N++ + A E+ + + + ASSEG +E + L +
Sbjct: 732 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ---LEA 788
Query: 252 HEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKD 311
EK++ + I+ E+S+ + L+ + ++ ++E L+ +S +E+E + ++
Sbjct: 789 AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK 848
Query: 312 LIKTEEMNTKYQRDIREA---MAQKED-----------MEERITTLEKRYLSAQRESTSI 357
+ E QR ++E + QKE+ + E + +E ++ +
Sbjct: 849 FAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL 908
Query: 358 HDMNDKLENELA-------NKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPE-- 408
+KLEN++A + + L +M ++ R + +E + KL + A L +
Sbjct: 909 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 968
Query: 409 ----VEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQR-EKMNEE--- 460
V+AE +Q+ AA K EE +E ++ LE ++E + + Q + R E+ E
Sbjct: 969 EDMTVKAEQSQQEAA-KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 1027
Query: 461 HNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAE 520
++ + + + L ++ ++L+ A EE + L+QE E RK +++ + AE
Sbjct: 1028 KHEEILQNLQKTLLDTEDKLK-------GAREENSGLLQELEELRKQADKA--KAAQTAE 1078
Query: 521 EIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQ----SDYRTTKVIR 576
+ ++ ++ + K T + +E T T+A+L+ + +L ++ + +K +
Sbjct: 1079 DAMQIMEQMTKEKTETLASLEDT-----KQTNAKLQNELDTLKENNLKNVEELNKSKELL 1133
Query: 577 RPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMD 636
+M R E +++L ++QQ+ L E + ++++ R+ + S
Sbjct: 1134 TVENQKMEEFRKE--IETLKQAAAQKSQQLSALQ----EENVKLAEELGRSRDEVTSHQK 1187
Query: 637 LLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTE 675
L + Q L M +E +K I+ EEK S +
Sbjct: 1188 LEEERSVLNNQLLEMKKRE-----SKFIKDADEEKASLQ 1221
Score = 71.2 bits (173), Expect = 6e-12
Identities = 122/609 (20%), Positives = 243/609 (39%), Gaps = 88/609 (14%)
Query: 27 SDSHFEQLMVNMLDERDRLLDTLRETQE---SLSLAQQRLQDVIYDRDSLQRQLNSALPQ 83
++ + L + E + RE Q L+ Q+ L +V +++L+++L +
Sbjct: 789 AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK 848
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLEC 143
E+ E ++ + + +L +KEE+ + L ++ R L +E
Sbjct: 849 FAEA------------SEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEA 896
Query: 144 LV-SRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERV 202
+ ER ++ K + ++ ++ + +K ++ L K+ + LR+ V
Sbjct: 897 KFREKDEREEQLIKAKEKLEN--------DIAEIMKMSGDNSSQLT-KMNDELRLKERDV 947
Query: 203 SALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSID 262
L+ +L AN+ L++ + K S+ +H E +K E++LS+
Sbjct: 948 EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----EEEKKELERKLSDLEKK 1003
Query: 263 STDETSQIVELQELLEKQNYEM-AQMKERLAALSSRVGEVEQEAETARKD----LIKTEE 317
+Q EL+ E+ E + +E L L + + E + + AR++ L + EE
Sbjct: 1004 METSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE 1063
Query: 318 MNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELAN-KEAILR 376
+ + Q D +A ED + + + K N KL+NEL KE L+
Sbjct: 1064 L--RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1121
Query: 377 QMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTK-----AEE------ 425
+EE N+ +E L + QK+++ ++ ETL + A+ +Q+++AL + AEE
Sbjct: 1122 NVEELNKS-KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1180
Query: 426 ---RHGNIEERMRHLEGQL--------------------------------EEKNQELQR 450
H +EE L QL EK+ EL++
Sbjct: 1181 EVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEK 1240
Query: 451 ARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEE 510
R + N + T +++++L LK + L+ K Q S + +
Sbjct: 1241 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1300
Query: 511 SLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYR 570
+ D+ +I+ L S + L+ + L + + + A L + L + SD +
Sbjct: 1301 ADEDERAQESQIDFLNSVIVDLQRKNQDL----KMKVEMMSEAALNGNGDDLNNYDSDDQ 1356
Query: 571 TTKVIRRPR 579
+ ++PR
Sbjct: 1357 EKQSKKKPR 1365
Score = 63.9 bits (154), Expect = 9e-10
Identities = 121/617 (19%), Positives = 245/617 (39%), Gaps = 86/617 (13%)
Query: 112 ACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEV 171
A +E L EK++ I +L AER+ R + V E+ L A + G V
Sbjct: 352 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQEL--------ALARDGHDQHV 403
Query: 172 EVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMA 231
L+A L V R +E ++ LEEE + E+++
Sbjct: 404 LELEAKMD------QLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI----TKG 453
Query: 232 SSEGSTESEHLEGMEPGQKV---------HEKRLSNGSIDSTDETSQIVELQELLEKQNY 282
E T+ EH E Q + ++ L + + + E S+I+EL++ L +
Sbjct: 454 DLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQ 513
Query: 283 EMAQMKERL------------AALSSRVGEVEQEAETARKD----LIKTEE----MNTKY 322
E+A+++ RL +L + ++++ E R D + +E +
Sbjct: 514 EVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETH 573
Query: 323 QRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDM-NDKLENELANKEAILRQMEEK 381
Q++I+ E + + +L+ + A +E++ + + KLE +A+ + + +++
Sbjct: 574 QKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVS 633
Query: 382 -NRQL-QERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMR-HLE 438
++ L E E AE K Q + + E+E Q+ H E +R L
Sbjct: 634 FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ----DSERAAHAKEMEALRAKLM 689
Query: 439 GQLEEKNQELQRARQR-EKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVL 497
++EK L+ R + +K ++H + DT+++L + E L+ A E+ +
Sbjct: 690 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL--QEAEIKVKELEVLQAKCNEQTKV 747
Query: 498 IQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRY 557
I + K EE L D + L + + +SE+ +L+ + E I ++ +AE
Sbjct: 748 IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL-EAAEKQIKHLEIEKNAE--- 803
Query: 558 SVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESD 617
+ + + R + + + + + + + +++ +L E+
Sbjct: 804 ----------SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 853
Query: 618 TEMSDIDDDDRETI------FSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEK 671
E + +ET+ ++LS SD + L+E L + + R E +
Sbjct: 854 EEAVSVQRSMQETVNKLHQKEEQFNMLS----SDLE----KLRENLADMEAKFREKDERE 905
Query: 672 ESTELRAEEIENRVASV 688
E E++EN +A +
Sbjct: 906 EQLIKAKEKLENDIAEI 922
Score = 35.4 bits (80), Expect = 0.35
Identities = 49/228 (21%), Positives = 99/228 (43%), Gaps = 27/228 (11%)
Query: 359 DMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIA 418
+ + + +++ A+ ++EK + +++ L + + + + + E+E ELA
Sbjct: 338 ETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA---- 393
Query: 419 ALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMN-----EEHNKRLSDTVDRLL 473
A + H ++ + LE ++++ + + A REK+ EE +++ D R+
Sbjct: 394 ---LARDGH---DQHVLELEAKMDQL-RTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
Query: 474 TESNER--LQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLR-SELD 530
ES + L+ K A ++E + +T L+ L D R+A EK R EL+
Sbjct: 447 EESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELED-TRVATVSEKSRIMELE 505
Query: 531 Q-LKMRTGSL------IEPTIPRTHLDTSAELRYSVGSLVDSQSDYRT 571
+ L +R + +E P +D S L + SL + RT
Sbjct: 506 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 553
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 96.3 bits (238), Expect = 2e-19
Identities = 135/635 (21%), Positives = 269/635 (42%), Gaps = 103/635 (16%)
Query: 109 ELNACREQLLEKEEEISELKA-------ERNNTRLLLEHLECLVSRHERSLRMTVVKRQA 161
E+ EQ+ K+EEI +L++ ERN RL + LE +S E + +T +
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRIS--ELTSELTDERNTG 1305
Query: 162 QSPSGV--SSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIV-- 217
+S S + + E L+A K + E D ++ + +E + A A N E+
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDD 1365
Query: 218 ------------ALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTD 265
A+RE + +R E E E + ++ E+RL + DS +
Sbjct: 1366 DAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVE-----QQNKRQLERRLGDLQADSEE 1420
Query: 266 ETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVE-----------QEAETARKDLIK 314
+ +L++ ++ E+ K L R E+E Q E A+++ ++
Sbjct: 1421 SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQ 1480
Query: 315 TEEMNTKYQRDIREAMAQKEDMEER---ITTLEKRYLSAQRESTSIHDMNDKLENELANK 371
E++ + + EA + K+ +EE+ I ++ +S + E I K E LA
Sbjct: 1481 REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKV 1540
Query: 372 EAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALT------KAEE 425
+ LR +E K + +E L+ +Q + +A+ E+E E ++ + + EE
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAGTIQM-LEQAKLRLEMEMERMRQTHSKEMESRDEEVEE 1599
Query: 426 RHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLK 485
+ +++++ +E QLEE+ ++ Q+ + ++ E LSD V+R ES +RL+ LK
Sbjct: 1600 ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLK 1659
Query: 486 ERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIP 545
A L + +++ +L+ S K EI +L+++L++ + + ++
Sbjct: 1660 RTKALLADAQLMLD-------HLKNSAPSK----REIAQLKNQLEESEFTCAAAVK---A 1705
Query: 546 RTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQ 605
R ++ E + +D D K K+ + + +R Q+
Sbjct: 1706 RKAMEVEIE---DLHLQID-----------------------DIAKAKTALEEQLSRLQR 1739
Query: 606 IGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMM--LQEQLDAINKE 663
E+ + ++D+E + M + ++ LA + LQ QL+ NKE
Sbjct: 1740 ----------EKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 664 IRLIQEEKESTELRAEEIENRVASVSLEGLNLARV 698
+ +QE+ ++ + + E +E + SL A++
Sbjct: 1790 KQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKI 1824
Score = 88.2 bits (217), Expect = 4e-17
Identities = 130/624 (20%), Positives = 250/624 (40%), Gaps = 68/624 (10%)
Query: 26 DSDSHFE--QLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQ 83
D+ H E Q+ + L+++ R D+ LS A + Q R+ LQR+ + L +
Sbjct: 1441 DTKLHLEGQQVRNHELEKKQRRFDS------ELSQAHEEAQREKLQREKLQREKDMLLAE 1494
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLEC 143
L + A T+++ + +L + + S+ +A + L LE
Sbjct: 1495 AFS-----LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEA 1549
Query: 144 LVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVS 203
V E L Q + + E+E+ + ++ + ++ DE+V E + +++
Sbjct: 1550 KVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLK 1609
Query: 204 ALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEG---MEPGQKVHEKRLSNGS 260
+E +L ++ + + ++ K+A+ E + K + L++
Sbjct: 1610 QMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQ 1669
Query: 261 I------DSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIK 314
+ +S +I +L+ LE+ + A + A+ + ++ + + K
Sbjct: 1670 LMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTA 1729
Query: 315 TEEMNTKYQRDIREAMAQKEDMEERITTLEKRY----LSAQRESTSIHDMNDKLENELAN 370
EE ++ QR+ E + E+ +E + L K++ A R+ I+D+ +LE AN
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEE--AN 1787
Query: 371 KEAILRQMEEKNRQLQERLELAEQKL---QQTMRKAETLPEVEAELAQRIAALTKAEERH 427
KE ++++EK + LQ ++E EQ + R+ + E+E L + + E
Sbjct: 1788 KEK--QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 428 GNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKER 487
++E M L EE++Q + + ++ N+ ++L DT KE
Sbjct: 1846 SRLKENMEKL---TEERDQRIAAENREKEQNKRLQRQLRDT----------------KEE 1886
Query: 488 MAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRT 547
M L K E+E RK E + D E L + L+++L R G L
Sbjct: 1887 MGELARK-----EAEASRKKHELEM-DLESLEAANQSLQADLKLAFKRIGDLQAAIEDEM 1940
Query: 548 HLDTSAELRYSVG-SLVDSQSDYRT--TKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQ 604
D + +L S G S VDS+ + R K +G D+ +KS + +
Sbjct: 1941 ESDENEDLINSEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWK-- 1998
Query: 605 QIGVLSSHPFESDTEMSDIDDDDR 628
S P SD E +D+ R
Sbjct: 1999 -----SLAPDRSDDEHDPLDNTSR 2017
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 96.3 bits (238), Expect = 2e-19
Identities = 135/635 (21%), Positives = 269/635 (42%), Gaps = 103/635 (16%)
Query: 109 ELNACREQLLEKEEEISELKA-------ERNNTRLLLEHLECLVSRHERSLRMTVVKRQA 161
E+ EQ+ K+EEI +L++ ERN RL + LE +S E + +T +
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRIS--ELTSELTDERNTG 1305
Query: 162 QSPSGV--SSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIV-- 217
+S S + + E L+A K + E D ++ + +E + A A N E+
Sbjct: 1306 ESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDD 1365
Query: 218 ------------ALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTD 265
A+RE + +R E E E + ++ E+RL + DS +
Sbjct: 1366 DAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVE-----QQNKRQLERRLGDLQADSEE 1420
Query: 266 ETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVE-----------QEAETARKDLIK 314
+ +L++ ++ E+ K L R E+E Q E A+++ ++
Sbjct: 1421 SQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQ 1480
Query: 315 TEEMNTKYQRDIREAMAQKEDMEER---ITTLEKRYLSAQRESTSIHDMNDKLENELANK 371
E++ + + EA + K+ +EE+ I ++ +S + E I K E LA
Sbjct: 1481 REKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKV 1540
Query: 372 EAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALT------KAEE 425
+ LR +E K + +E L+ +Q + +A+ E+E E ++ + + EE
Sbjct: 1541 KKQLRDLEAKVKDQEEELDEQAGTIQM-LEQAKLRLEMEMERMRQTHSKEMESRDEEVEE 1599
Query: 426 RHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLK 485
+ +++++ +E QLEE+ ++ Q+ + ++ E LSD V+R ES +RL+ LK
Sbjct: 1600 ARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLK 1659
Query: 486 ERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIP 545
A L + +++ +L+ S K EI +L+++L++ + + ++
Sbjct: 1660 RTKALLADAQLMLD-------HLKNSAPSK----REIAQLKNQLEESEFTCAAAVK---A 1705
Query: 546 RTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQ 605
R ++ E + +D D K K+ + + +R Q+
Sbjct: 1706 RKAMEVEIE---DLHLQID-----------------------DIAKAKTALEEQLSRLQR 1739
Query: 606 IGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMM--LQEQLDAINKE 663
E+ + ++D+E + M + ++ LA + LQ QL+ NKE
Sbjct: 1740 ----------EKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKE 1789
Query: 664 IRLIQEEKESTELRAEEIENRVASVSLEGLNLARV 698
+ +QE+ ++ + + E +E + SL A++
Sbjct: 1790 KQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKI 1824
Score = 86.3 bits (212), Expect = 2e-16
Identities = 116/566 (20%), Positives = 230/566 (40%), Gaps = 61/566 (10%)
Query: 26 DSDSHFE--QLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQ 83
D+ H E Q+ + L+++ R D+ LS A + Q R+ LQR+ + L +
Sbjct: 1441 DTKLHLEGQQVRNHELEKKQRRFDS------ELSQAHEEAQREKLQREKLQREKDMLLAE 1494
Query: 84 DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLEC 143
L + A T+++ + +L + + S+ +A + L LE
Sbjct: 1495 AFS-----LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEA 1549
Query: 144 LVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVS 203
V E L Q + + E+E+ + ++ + ++ DE+V E + +++
Sbjct: 1550 KVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLK 1609
Query: 204 ALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEG---MEPGQKVHEKRLSNGS 260
+E +L ++ + + ++ K+A+ E + K + L++
Sbjct: 1610 QMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQ 1669
Query: 261 I------DSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIK 314
+ +S +I +L+ LE+ + A + A+ + ++ + + K
Sbjct: 1670 LMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTA 1729
Query: 315 TEEMNTKYQRDIREAMAQKEDMEERITTLEKRY----LSAQRESTSIHDMNDKLENELAN 370
EE ++ QR+ E + E+ +E + L K++ A R+ I+D+ +LE AN
Sbjct: 1730 LEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEE--AN 1787
Query: 371 KEAILRQMEEKNRQLQERLELAEQKL---QQTMRKAETLPEVEAELAQRIAALTKAEERH 427
KE ++++EK + LQ ++E EQ + R+ + E+E L + + E
Sbjct: 1788 KEK--QELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 428 GNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKER 487
++E M L EE++Q + + ++ N+ ++L DT KE
Sbjct: 1846 SRLKENMEKL---TEERDQRIAAENREKEQNKRLQRQLRDT----------------KEE 1886
Query: 488 MAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRT 547
M L K E+E RK E + D E L + L+++L R G L
Sbjct: 1887 MGELARK-----EAEASRKKHELEM-DLESLEAANQSLQADLKLAFKRIGDLQAAIEDEM 1940
Query: 548 HLDTSAELRYSVGSLVDSQSDYRTTK 573
D + +L + SL D + Y+ K
Sbjct: 1941 ESDENEDL---INSLQDMVTKYQKRK 1963
Score = 69.3 bits (168), Expect = 2e-11
Identities = 110/460 (23%), Positives = 191/460 (41%), Gaps = 68/460 (14%)
Query: 32 EQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSA---LPQDIESL 88
EQ + + E +R+ T + ES R ++V R S Q++L L ++ E
Sbjct: 1569 EQAKLRLEMEMERMRQTHSKEMES------RDEEVEEARQSCQKKLKQMEVQLEEEYEDK 1622
Query: 89 TGGLAGSKGADPPEFAALTKELNACREQLLEKE--EEISELKAERNNTRLLLEHLECLVS 146
L + + + A L+ ++N R+ EK +++ KA + +L+L+HL
Sbjct: 1623 QKVLREKRELEG-KLATLSDQVNR-RDFESEKRLRKDLKRTKALLADAQLMLDHL----- 1675
Query: 147 RHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALE 206
K A S E+ LK E A K R+ + V +E +
Sbjct: 1676 -----------KNSAPS----KREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 207 EELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDE 266
+++A A AL EQ +QR+ + E + E M K H+ ++ S D
Sbjct: 1721 DDIAKAK---TALEEQLSRLQREKNEIQNRLEEDQ-EDMNELMKKHKAAVAQASRD---- 1772
Query: 267 TSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQ---EAETARKDLIKTEEMNTKYQ 323
+QI +LQ LE+ N E +++E+L AL S+V +EQ + + K E+ T+ +
Sbjct: 1773 LAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLE 1832
Query: 324 RDIRE-------AMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLEN------ELAN 370
+ + A KE+ME+ ++R + RE + +L + ELA
Sbjct: 1833 FERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELAR 1892
Query: 371 KEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNI 430
KEA + + + E LE A Q LQ ++ A +RI L A E
Sbjct: 1893 KEAEASRKKHELEMDLESLEAANQSLQADLKLA----------FKRIGDLQAAIEDEMES 1942
Query: 431 EERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVD 470
+E L L++ + Q+ + + + + + + L D VD
Sbjct: 1943 DEN-EDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVD 1981
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 95.9 bits (237), Expect = 2e-19
Identities = 186/904 (20%), Positives = 356/904 (39%), Gaps = 112/904 (12%)
Query: 58 LAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQL 117
L Q QD + + + Q L Q G L G E A L ++L A E
Sbjct: 869 LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELC 928
Query: 118 LEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRM--TVVKRQAQSPSGVSSEVEVLK 175
E EE L A + L++ LE V E R T KR Q + + +E +
Sbjct: 929 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 988
Query: 176 ALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEG 235
+ + K E ++ E + LE++ + ++E L ++ + A E
Sbjct: 989 GARQKLQLEKVTTEAKMKKFE---EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEE 1045
Query: 236 STES----------------EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEK 279
+S + L E G++ EK +S++ Q+VE Q+ E+
Sbjct: 1046 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1105
Query: 280 QNYEMAQMKERLAALSSR---------------------VGEVEQEAETARKDLIKTEEM 318
++ + +E L A +R + E +++ E+ R K E
Sbjct: 1106 LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE-- 1163
Query: 319 NTKYQRDIREAM-AQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQ 377
K +RD+ E + A + ++E+ + + + + + ++ LE E EA +++
Sbjct: 1164 --KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1221
Query: 378 MEEKNRQLQERLELAEQKLQQTMRKA---ETLPEVEAELAQRIAALTKAEERHGNIEERM 434
+ +++ Q ELAEQ Q K +T +EAE+++ A L+ + E+R
Sbjct: 1222 LRQRHGQALG--ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR 1279
Query: 435 RHLEGQLEEKN--------------QELQRARQREK-----MNEEHNK--RLS---DTVD 470
R LE QL+E ++LQRA+ + +NE +K RLS + +
Sbjct: 1280 RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTE 1339
Query: 471 RLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELD 530
L ++ E LQ + ++A + E+ R+ LEE +ER E++ +++L
Sbjct: 1340 AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1399
Query: 531 QLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEP 590
+ + R E A R + + +Q T+ + R RGR ++++
Sbjct: 1400 EWRRRQ----EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQE-- 1453
Query: 591 KVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLA 650
L D + QQ ++S+ + + + +++ + +++ + + A
Sbjct: 1454 ----LDDATMDLEQQRQLVSTLE-KKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1508
Query: 651 MMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTA 710
L R ++EE+E+ E E +NR LE L ++ G S+ A
Sbjct: 1509 RAL--------SLTRALEEEQEARE--ELERQNRALRAELEALLSSKDDVGKSVHELERA 1558
Query: 711 SSLASSSPPSGHS-TPKLTPRSPAREMDRMGV-MTLPSDLRKHRRKIAVVEEDGREDKAT 768
+A + + +L A E ++ + +T+ + +H R + +E G E +
Sbjct: 1559 CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1618
Query: 769 IKCETSPPPTPR-ALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKK 827
+ + R R TL + AR L LE + SA ++ K +K
Sbjct: 1619 LAKQLRDAEVERDEERKQRTLAVA----ARKKLEGELEELKAQMASAGQGKEEAVKQLRK 1674
Query: 828 KGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEE 887
+++ + L+ + E+ R + F + + + GL +AE RL+++ +
Sbjct: 1675 --MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL-----EAEV-LRLQEELAASDR 1726
Query: 888 ARRK 891
ARR+
Sbjct: 1727 ARRQ 1730
Score = 87.4 bits (215), Expect = 8e-17
Identities = 126/527 (23%), Positives = 217/527 (41%), Gaps = 71/527 (13%)
Query: 33 QLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGL 92
+ + L E+ +D L + L QQ L D D + QRQL S L + L
Sbjct: 1427 EALTQRLAEKTETVDRLERGRRRL---QQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLL 1482
Query: 93 AGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSL 152
A K A +E + E+E L + E LE R R+L
Sbjct: 1483 AEEKAA----VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELE----RQNRAL 1534
Query: 153 RMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAA 212
R A+ + +SS+ +V K++ L E + E+ LR +V+ LE+EL AA
Sbjct: 1535 R-------AELEALLSSKDDVGKSVHEL-ERACRVAEQAANDLRA---QVTELEDELTAA 1583
Query: 213 NQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVE 272
+ L V +Q E + G E +++ K+L + ++ +E Q
Sbjct: 1584 EDAKLRLE---VTVQALKTQHERDLQGRDEAGEERRRQL-AKQLRDAEVERDEERKQRTL 1639
Query: 273 LQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQ 332
+K E+ ++K ++A+ Q E A K L K + + R++ E
Sbjct: 1640 AVAARKKLEGELEELKAQMASAG-------QGKEEAVKQLRKMQAQMKELWREVEETRTS 1692
Query: 333 KEDM-------EERITTLEKRYLSAQRESTS-------IHDMNDKLENELANKEAILRQM 378
+E++ E+R+ LE L Q E + D++ +E+AN +
Sbjct: 1693 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1752
Query: 379 EEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALT-----------KAEERH 427
E+ RQL+ RL E++L++ +E L + +L ++ +LT KAE
Sbjct: 1753 LEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGR 1812
Query: 428 GNIEERMRHLEGQLEEKNQELQRARQREKMN-EEHNKRLSDTVDRLLTESNERLQLHLKE 486
+E +++ L G+L E++ AR R KM +L+ ++L E+ ER+
Sbjct: 1813 QQLERQIQELRGRLGEED---AGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1869
Query: 487 RMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLK 533
R A K V++Q +EE ++L +++EK + QLK
Sbjct: 1870 RRAEKRLKEVVLQ--------VEEERRVADQLRDQLEKGNLRVKQLK 1908
Score = 85.5 bits (210), Expect = 3e-16
Identities = 108/505 (21%), Positives = 202/505 (40%), Gaps = 34/505 (6%)
Query: 35 MVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAG 94
M + L + ++ L + + L LQ+ + ++ +L + L + E L LA
Sbjct: 1064 MEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR 1123
Query: 95 SKGADPPEFAALTKELNACREQLLEKEEE-----ISELKAERNNTRLLLEHLECLVSRHE 149
++ A L K L + L E +E+ ++ KAE+ R L E LE L E
Sbjct: 1124 AEDEGGAR-AQLLKSLREAQAALAEAQEDLESERVARTKAEKQR-RDLGEELEALRGELE 1181
Query: 150 RSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEEL 209
+L T +++ +S E EV + K+L E + + V+E + + + L E+L
Sbjct: 1182 DTLDSTNAQQELRS----KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQL 1237
Query: 210 AAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDST--DET 267
A + A + + ++ +++ S E Q+ L + D
Sbjct: 1238 EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGE 1297
Query: 268 SQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIR 327
E E L++ E+ + S + E E + K+L TE Q ++
Sbjct: 1298 RARAEAAEKLQRAQAELENV-------SGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1350
Query: 328 EAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQE 387
E K + R+ +E + + ++ EL +A L + + +
Sbjct: 1351 EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAG 1410
Query: 388 RLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQE 447
LE E+ ++ R+AE L QR+A T+ +R +E R L+ +L++ +
Sbjct: 1411 ALEAGEEARRRAAREAEAL-------TQRLAEKTETVDR---LERGRRRLQQELDDATMD 1460
Query: 448 LQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKN 507
L++ RQ E+ ++ D+LL E + ++ER A E + + +
Sbjct: 1461 LEQQRQLVSTLEKKQRKF----DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRA 1516
Query: 508 LEESLHDKERLAEEIEKLRSELDQL 532
LEE +E L + LR+EL+ L
Sbjct: 1517 LEEEQEAREELERQNRALRAELEAL 1541
Score = 61.6 bits (148), Expect = 5e-09
Identities = 110/501 (21%), Positives = 198/501 (39%), Gaps = 76/501 (15%)
Query: 17 QRGSQSSGSDSDSHFEQLM-------VNMLDERDRLLDTLRETQESLSLAQQRLQDVIYD 69
QR S+ F+QL+ + ++ER+R RE + + L++
Sbjct: 1464 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1523
Query: 70 RDSLQRQLNSALPQDIESLTGGLAG-SKGADPPEFAALTKE--LNACREQLLEKEEEISE 126
R+ L+RQ N AL ++E+L K E A E N R Q+ E E+E++
Sbjct: 1524 REELERQ-NRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1582
Query: 127 LKAERNNTRLLLE-HLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLF---- 181
+ + +L LE ++ L ++HER L Q + +G ++ K L+
Sbjct: 1583 AE----DAKLRLEVTVQALKTQHERDL-------QGRDEAGEERRRQLAKQLRDAEVERD 1631
Query: 182 --EHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA-LREQNVHIQ----------- 227
+ L R++L LE + A +E V LR+ ++
Sbjct: 1632 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1691
Query: 228 -RKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQ 286
R+ S+ + L+G+E ++ L+ E+ + + N A
Sbjct: 1692 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1751
Query: 287 MKERLAALSSRVGEVEQEAETA-----------RKDLIKTEEMNTKYQRD---IREAMAQ 332
+ E L R+G++E+E E RK L++ E + T+ + +A +
Sbjct: 1752 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1811
Query: 333 KEDMEERITTLEKRYLSAQRESTSIHDMN-DKLENELANKEAILRQMEEKNRQLQERL-E 390
++ +E +I L R + + H M LE++LA E L Q E + R L +L
Sbjct: 1812 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ-ETRERILSGKLVR 1870
Query: 391 LAEQKLQQTMRKAETLPEVEAELAQRIAA-----------LTKAEERHGNIEERMRHLEG 439
AE++L++ + + E V +L ++ L +AEE + R L+
Sbjct: 1871 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1930
Query: 440 QLEEKNQELQRARQREKMNEE 460
+LE+ + E MN E
Sbjct: 1931 ELEDVTE------SAESMNRE 1945
Score = 52.8 bits (125), Expect = 2e-06
Identities = 72/310 (23%), Positives = 130/310 (41%), Gaps = 55/310 (17%)
Query: 42 RDRLLDTLRETQESLSLAQQ---RLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGA 98
R+ + RE+++ L + RLQ+ + D +RQ QD + + +A +
Sbjct: 1693 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ----QDRDEMADEVANGNLS 1748
Query: 99 DPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 158
AA+ +E +L + EEE+ E E++N+ LL + L+ + E SL +
Sbjct: 1749 K----AAILEEKRQLEGRLGQLEEELEE---EQSNSELLNDRYRKLLLQVE-SLTTELSA 1800
Query: 159 RQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA 218
++ S S ++ + ++ L D R R +++ ++ALE +LA A +++
Sbjct: 1801 ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT---IAALESKLAQAEEQL-- 1855
Query: 219 LREQNVHIQRKMASSEGSTESEHLEGMEPGQKVH--EKRLSNGSIDSTDETSQIVELQEL 276
E E E + G+ V EKRL + +E +L++
Sbjct: 1856 -------------------EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQ 1896
Query: 277 LEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDM 336
LEK N + Q+K +L E E+EA A+ + QR++ + E M
Sbjct: 1897 LEKGNLRVKQLKRQLE-------EAEEEASRAQAG-------RRRLQRELEDVTESAESM 1942
Query: 337 EERITTLEKR 346
+TTL R
Sbjct: 1943 NREVTTLRNR 1952
Score = 50.8 bits (120), Expect = 8e-06
Identities = 78/374 (20%), Positives = 158/374 (42%), Gaps = 59/374 (15%)
Query: 61 QRLQDVIYDRDSLQRQLNSA------LPQDIESLTGGLAGSKGADPPEFAALTKELNACR 114
++L+D +RD ++Q A L ++E L +A S G E +++ A
Sbjct: 1621 KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA-SAGQGKEEAVKQLRKMQAQM 1679
Query: 115 EQLLEKEEEI----SELKAERNNTRLLLEHLECLVSRHERSLRMTV-VKRQAQSPSGVSS 169
++L + EE E+ ++ + L+ LE V R + L + +RQAQ +
Sbjct: 1680 KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA 1739
Query: 170 EVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAA--ANQEIVALREQNVHIQ 227
+ + L+EK R R+ LEEEL +N E++ R + + +Q
Sbjct: 1740 D----EVANGNLSKAAILEEK-----RQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1790
Query: 228 RKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELL-EKQNYEMAQ 286
+ ++E S E E G++ E+ QI EL+ L E+ A+
Sbjct: 1791 VESLTTELSAERSFSAKAESGRQQLER--------------QIQELRGRLGEEDAGARAR 1836
Query: 287 MKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKR 346
K +AAL S++ + E++ E ++ I + ++ + ++ ++E + Q E+ E R+
Sbjct: 1837 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVA----- 1890
Query: 347 YLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETL 406
D+L ++L ++Q++ + + +E A+ ++ R+ E +
Sbjct: 1891 ---------------DQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1935
Query: 407 PEVEAELAQRIAAL 420
E + + + L
Sbjct: 1936 TESAESMNREVTTL 1949
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 95.9 bits (237), Expect = 2e-19
Identities = 186/904 (20%), Positives = 356/904 (39%), Gaps = 112/904 (12%)
Query: 58 LAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQL 117
L Q QD + + + Q L Q G L G E A L ++L A E
Sbjct: 861 LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELC 920
Query: 118 LEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRM--TVVKRQAQSPSGVSSEVEVLK 175
E EE L A + L++ LE V E R T KR Q + + +E +
Sbjct: 921 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 980
Query: 176 ALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEG 235
+ + K E ++ E + LE++ + ++E L ++ + A E
Sbjct: 981 GARQKLQLEKVTTEAKMKKFE---EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEE 1037
Query: 236 STES----------------EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEK 279
+S + L E G++ EK +S++ Q+VE Q+ E+
Sbjct: 1038 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1097
Query: 280 QNYEMAQMKERLAALSSR---------------------VGEVEQEAETARKDLIKTEEM 318
++ + +E L A +R + E +++ E+ R K E
Sbjct: 1098 LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE-- 1155
Query: 319 NTKYQRDIREAM-AQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQ 377
K +RD+ E + A + ++E+ + + + + + ++ LE E EA +++
Sbjct: 1156 --KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1213
Query: 378 MEEKNRQLQERLELAEQKLQQTMRKA---ETLPEVEAELAQRIAALTKAEERHGNIEERM 434
+ +++ Q ELAEQ Q K +T +EAE+++ A L+ + E+R
Sbjct: 1214 LRQRHGQALG--ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR 1271
Query: 435 RHLEGQLEEKN--------------QELQRARQREK-----MNEEHNK--RLS---DTVD 470
R LE QL+E ++LQRA+ + +NE +K RLS + +
Sbjct: 1272 RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTE 1331
Query: 471 RLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELD 530
L ++ E LQ + ++A + E+ R+ LEE +ER E++ +++L
Sbjct: 1332 AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1391
Query: 531 QLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEP 590
+ + R E A R + + +Q T+ + R RGR ++++
Sbjct: 1392 EWRRRQ----EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQE-- 1445
Query: 591 KVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLA 650
L D + QQ ++S+ + + + +++ + +++ + + A
Sbjct: 1446 ----LDDATMDLEQQRQLVSTLE-KKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1500
Query: 651 MMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTA 710
L R ++EE+E+ E E +NR LE L ++ G S+ A
Sbjct: 1501 RAL--------SLTRALEEEQEARE--ELERQNRALRAELEALLSSKDDVGKSVHELERA 1550
Query: 711 SSLASSSPPSGHS-TPKLTPRSPAREMDRMGV-MTLPSDLRKHRRKIAVVEEDGREDKAT 768
+A + + +L A E ++ + +T+ + +H R + +E G E +
Sbjct: 1551 CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1610
Query: 769 IKCETSPPPTPR-ALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKK 827
+ + R R TL + AR L LE + SA ++ K +K
Sbjct: 1611 LAKQLRDAEVERDEERKQRTLAVA----ARKKLEGELEELKAQMASAGQGKEEAVKQLRK 1666
Query: 828 KGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEE 887
+++ + L+ + E+ R + F + + + GL +AE RL+++ +
Sbjct: 1667 --MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL-----EAEV-LRLQEELAASDR 1718
Query: 888 ARRK 891
ARR+
Sbjct: 1719 ARRQ 1722
Score = 87.4 bits (215), Expect = 8e-17
Identities = 126/527 (23%), Positives = 217/527 (41%), Gaps = 71/527 (13%)
Query: 33 QLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGL 92
+ + L E+ +D L + L QQ L D D + QRQL S L + L
Sbjct: 1419 EALTQRLAEKTETVDRLERGRRRL---QQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLL 1474
Query: 93 AGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSL 152
A K A +E + E+E L + E LE R R+L
Sbjct: 1475 AEEKAA----VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELE----RQNRAL 1526
Query: 153 RMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAA 212
R A+ + +SS+ +V K++ L E + E+ LR +V+ LE+EL AA
Sbjct: 1527 R-------AELEALLSSKDDVGKSVHEL-ERACRVAEQAANDLRA---QVTELEDELTAA 1575
Query: 213 NQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVE 272
+ L V +Q E + G E +++ K+L + ++ +E Q
Sbjct: 1576 EDAKLRLE---VTVQALKTQHERDLQGRDEAGEERRRQL-AKQLRDAEVERDEERKQRTL 1631
Query: 273 LQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQ 332
+K E+ ++K ++A+ Q E A K L K + + R++ E
Sbjct: 1632 AVAARKKLEGELEELKAQMASAG-------QGKEEAVKQLRKMQAQMKELWREVEETRTS 1684
Query: 333 KEDM-------EERITTLEKRYLSAQRESTS-------IHDMNDKLENELANKEAILRQM 378
+E++ E+R+ LE L Q E + D++ +E+AN +
Sbjct: 1685 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1744
Query: 379 EEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALT-----------KAEERH 427
E+ RQL+ RL E++L++ +E L + +L ++ +LT KAE
Sbjct: 1745 LEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGR 1804
Query: 428 GNIEERMRHLEGQLEEKNQELQRARQREKMN-EEHNKRLSDTVDRLLTESNERLQLHLKE 486
+E +++ L G+L E++ AR R KM +L+ ++L E+ ER+
Sbjct: 1805 QQLERQIQELRGRLGEED---AGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1861
Query: 487 RMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLK 533
R A K V++Q +EE ++L +++EK + QLK
Sbjct: 1862 RRAEKRLKEVVLQ--------VEEERRVADQLRDQLEKGNLRVKQLK 1900
Score = 85.5 bits (210), Expect = 3e-16
Identities = 108/505 (21%), Positives = 202/505 (40%), Gaps = 34/505 (6%)
Query: 35 MVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAG 94
M + L + ++ L + + L LQ+ + ++ +L + L + E L LA
Sbjct: 1056 MEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR 1115
Query: 95 SKGADPPEFAALTKELNACREQLLEKEEE-----ISELKAERNNTRLLLEHLECLVSRHE 149
++ A L K L + L E +E+ ++ KAE+ R L E LE L E
Sbjct: 1116 AEDEGGAR-AQLLKSLREAQAALAEAQEDLESERVARTKAEKQR-RDLGEELEALRGELE 1173
Query: 150 RSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEEL 209
+L T +++ +S E EV + K+L E + + V+E + + + L E+L
Sbjct: 1174 DTLDSTNAQQELRS----KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQL 1229
Query: 210 AAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDST--DET 267
A + A + + ++ +++ S E Q+ L + D
Sbjct: 1230 EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGE 1289
Query: 268 SQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIR 327
E E L++ E+ + S + E E + K+L TE Q ++
Sbjct: 1290 RARAEAAEKLQRAQAELENV-------SGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1342
Query: 328 EAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQE 387
E K + R+ +E + + ++ EL +A L + + +
Sbjct: 1343 EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAG 1402
Query: 388 RLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQE 447
LE E+ ++ R+AE L QR+A T+ +R +E R L+ +L++ +
Sbjct: 1403 ALEAGEEARRRAAREAEAL-------TQRLAEKTETVDR---LERGRRRLQQELDDATMD 1452
Query: 448 LQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKN 507
L++ RQ E+ ++ D+LL E + ++ER A E + + +
Sbjct: 1453 LEQQRQLVSTLEKKQRKF----DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRA 1508
Query: 508 LEESLHDKERLAEEIEKLRSELDQL 532
LEE +E L + LR+EL+ L
Sbjct: 1509 LEEEQEAREELERQNRALRAELEAL 1533
Score = 61.6 bits (148), Expect = 5e-09
Identities = 110/501 (21%), Positives = 198/501 (39%), Gaps = 76/501 (15%)
Query: 17 QRGSQSSGSDSDSHFEQLM-------VNMLDERDRLLDTLRETQESLSLAQQRLQDVIYD 69
QR S+ F+QL+ + ++ER+R RE + + L++
Sbjct: 1456 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1515
Query: 70 RDSLQRQLNSALPQDIESLTGGLAG-SKGADPPEFAALTKE--LNACREQLLEKEEEISE 126
R+ L+RQ N AL ++E+L K E A E N R Q+ E E+E++
Sbjct: 1516 REELERQ-NRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1574
Query: 127 LKAERNNTRLLLE-HLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLF---- 181
+ + +L LE ++ L ++HER L Q + +G ++ K L+
Sbjct: 1575 AE----DAKLRLEVTVQALKTQHERDL-------QGRDEAGEERRRQLAKQLRDAEVERD 1623
Query: 182 --EHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA-LREQNVHIQ----------- 227
+ L R++L LE + A +E V LR+ ++
Sbjct: 1624 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1683
Query: 228 -RKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQ 286
R+ S+ + L+G+E ++ L+ E+ + + N A
Sbjct: 1684 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1743
Query: 287 MKERLAALSSRVGEVEQEAETA-----------RKDLIKTEEMNTKYQRD---IREAMAQ 332
+ E L R+G++E+E E RK L++ E + T+ + +A +
Sbjct: 1744 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1803
Query: 333 KEDMEERITTLEKRYLSAQRESTSIHDMN-DKLENELANKEAILRQMEEKNRQLQERL-E 390
++ +E +I L R + + H M LE++LA E L Q E + R L +L
Sbjct: 1804 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ-ETRERILSGKLVR 1862
Query: 391 LAEQKLQQTMRKAETLPEVEAELAQRIAA-----------LTKAEERHGNIEERMRHLEG 439
AE++L++ + + E V +L ++ L +AEE + R L+
Sbjct: 1863 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1922
Query: 440 QLEEKNQELQRARQREKMNEE 460
+LE+ + E MN E
Sbjct: 1923 ELEDVTE------SAESMNRE 1937
Score = 52.8 bits (125), Expect = 2e-06
Identities = 72/310 (23%), Positives = 130/310 (41%), Gaps = 55/310 (17%)
Query: 42 RDRLLDTLRETQESLSLAQQ---RLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGA 98
R+ + RE+++ L + RLQ+ + D +RQ QD + + +A +
Sbjct: 1685 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ----QDRDEMADEVANGNLS 1740
Query: 99 DPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 158
AA+ +E +L + EEE+ E E++N+ LL + L+ + E SL +
Sbjct: 1741 K----AAILEEKRQLEGRLGQLEEELEE---EQSNSELLNDRYRKLLLQVE-SLTTELSA 1792
Query: 159 RQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA 218
++ S S ++ + ++ L D R R +++ ++ALE +LA A +++
Sbjct: 1793 ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT---IAALESKLAQAEEQL-- 1847
Query: 219 LREQNVHIQRKMASSEGSTESEHLEGMEPGQKVH--EKRLSNGSIDSTDETSQIVELQEL 276
E E E + G+ V EKRL + +E +L++
Sbjct: 1848 -------------------EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQ 1888
Query: 277 LEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDM 336
LEK N + Q+K +L E E+EA A+ + QR++ + E M
Sbjct: 1889 LEKGNLRVKQLKRQLE-------EAEEEASRAQAG-------RRRLQRELEDVTESAESM 1934
Query: 337 EERITTLEKR 346
+TTL R
Sbjct: 1935 NREVTTLRNR 1944
Score = 50.8 bits (120), Expect = 8e-06
Identities = 78/374 (20%), Positives = 158/374 (42%), Gaps = 59/374 (15%)
Query: 61 QRLQDVIYDRDSLQRQLNSA------LPQDIESLTGGLAGSKGADPPEFAALTKELNACR 114
++L+D +RD ++Q A L ++E L +A S G E +++ A
Sbjct: 1613 KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA-SAGQGKEEAVKQLRKMQAQM 1671
Query: 115 EQLLEKEEEI----SELKAERNNTRLLLEHLECLVSRHERSLRMTV-VKRQAQSPSGVSS 169
++L + EE E+ ++ + L+ LE V R + L + +RQAQ +
Sbjct: 1672 KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA 1731
Query: 170 EVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAA--ANQEIVALREQNVHIQ 227
+ + L+EK R R+ LEEEL +N E++ R + + +Q
Sbjct: 1732 D----EVANGNLSKAAILEEK-----RQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1782
Query: 228 RKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELL-EKQNYEMAQ 286
+ ++E S E E G++ E+ QI EL+ L E+ A+
Sbjct: 1783 VESLTTELSAERSFSAKAESGRQQLER--------------QIQELRGRLGEEDAGARAR 1828
Query: 287 MKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKR 346
K +AAL S++ + E++ E ++ I + ++ + ++ ++E + Q E+ E R+
Sbjct: 1829 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVA----- 1882
Query: 347 YLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETL 406
D+L ++L ++Q++ + + +E A+ ++ R+ E +
Sbjct: 1883 ---------------DQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1927
Query: 407 PEVEAELAQRIAAL 420
E + + + L
Sbjct: 1928 TESAESMNREVTTL 1941
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 95.9 bits (237), Expect = 2e-19
Identities = 186/904 (20%), Positives = 356/904 (39%), Gaps = 112/904 (12%)
Query: 58 LAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQL 117
L Q QD + + + Q L Q G L G E A L ++L A E
Sbjct: 902 LLQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELC 961
Query: 118 LEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRM--TVVKRQAQSPSGVSSEVEVLK 175
E EE L A + L++ LE V E R T KR Q + + +E +
Sbjct: 962 AEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE 1021
Query: 176 ALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEG 235
+ + K E ++ E + LE++ + ++E L ++ + A E
Sbjct: 1022 GARQKLQLEKVTTEAKMKKFE---EDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEE 1078
Query: 236 STES----------------EHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEK 279
+S + L E G++ EK +S++ Q+VE Q+ E+
Sbjct: 1079 KVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEE 1138
Query: 280 QNYEMAQMKERLAALSSR---------------------VGEVEQEAETARKDLIKTEEM 318
++ + +E L A +R + E +++ E+ R K E
Sbjct: 1139 LRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAE-- 1196
Query: 319 NTKYQRDIREAM-AQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQ 377
K +RD+ E + A + ++E+ + + + + + ++ LE E EA +++
Sbjct: 1197 --KQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQE 1254
Query: 378 MEEKNRQLQERLELAEQKLQQTMRKA---ETLPEVEAELAQRIAALTKAEERHGNIEERM 434
+ +++ Q ELAEQ Q K +T +EAE+++ A L+ + E+R
Sbjct: 1255 LRQRHGQALG--ELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRR 1312
Query: 435 RHLEGQLEEKN--------------QELQRARQREK-----MNEEHNK--RLS---DTVD 470
R LE QL+E ++LQRA+ + +NE +K RLS + +
Sbjct: 1313 RRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTE 1372
Query: 471 RLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELD 530
L ++ E LQ + ++A + E+ R+ LEE +ER E++ +++L
Sbjct: 1373 AQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLS 1432
Query: 531 QLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEP 590
+ + R E A R + + +Q T+ + R RGR ++++
Sbjct: 1433 EWRRRQ----EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQE-- 1486
Query: 591 KVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLA 650
L D + QQ ++S+ + + + +++ + +++ + + A
Sbjct: 1487 ----LDDATMDLEQQRQLVSTLE-KKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREA 1541
Query: 651 MMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTA 710
L R ++EE+E+ E E +NR LE L ++ G S+ A
Sbjct: 1542 RAL--------SLTRALEEEQEARE--ELERQNRALRAELEALLSSKDDVGKSVHELERA 1591
Query: 711 SSLASSSPPSGHS-TPKLTPRSPAREMDRMGV-MTLPSDLRKHRRKIAVVEEDGREDKAT 768
+A + + +L A E ++ + +T+ + +H R + +E G E +
Sbjct: 1592 CRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQ 1651
Query: 769 IKCETSPPPTPR-ALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKK 827
+ + R R TL + AR L LE + SA ++ K +K
Sbjct: 1652 LAKQLRDAEVERDEERKQRTLAVA----ARKKLEGELEELKAQMASAGQGKEEAVKQLRK 1707
Query: 828 KGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEE 887
+++ + L+ + E+ R + F + + + GL +AE RL+++ +
Sbjct: 1708 --MQAQMKELWREVEETRTSREEIFSQNRESEKRLKGL-----EAEV-LRLQEELAASDR 1759
Query: 888 ARRK 891
ARR+
Sbjct: 1760 ARRQ 1763
Score = 87.4 bits (215), Expect = 8e-17
Identities = 126/527 (23%), Positives = 217/527 (41%), Gaps = 71/527 (13%)
Query: 33 QLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGL 92
+ + L E+ +D L + L QQ L D D + QRQL S L + L
Sbjct: 1460 EALTQRLAEKTETVDRLERGRRRL---QQELDDATMDLEQ-QRQLVSTLEKKQRKFDQLL 1515
Query: 93 AGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSL 152
A K A +E + E+E L + E LE R R+L
Sbjct: 1516 AEEKAA----VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELE----RQNRAL 1567
Query: 153 RMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAA 212
R A+ + +SS+ +V K++ L E + E+ LR +V+ LE+EL AA
Sbjct: 1568 R-------AELEALLSSKDDVGKSVHEL-ERACRVAEQAANDLRA---QVTELEDELTAA 1616
Query: 213 NQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVE 272
+ L V +Q E + G E +++ K+L + ++ +E Q
Sbjct: 1617 EDAKLRLE---VTVQALKTQHERDLQGRDEAGEERRRQL-AKQLRDAEVERDEERKQRTL 1672
Query: 273 LQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQ 332
+K E+ ++K ++A+ Q E A K L K + + R++ E
Sbjct: 1673 AVAARKKLEGELEELKAQMASAG-------QGKEEAVKQLRKMQAQMKELWREVEETRTS 1725
Query: 333 KEDM-------EERITTLEKRYLSAQRESTS-------IHDMNDKLENELANKEAILRQM 378
+E++ E+R+ LE L Q E + D++ +E+AN +
Sbjct: 1726 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAI 1785
Query: 379 EEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALT-----------KAEERH 427
E+ RQL+ RL E++L++ +E L + +L ++ +LT KAE
Sbjct: 1786 LEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGR 1845
Query: 428 GNIEERMRHLEGQLEEKNQELQRARQREKMN-EEHNKRLSDTVDRLLTESNERLQLHLKE 486
+E +++ L G+L E++ AR R KM +L+ ++L E+ ER+
Sbjct: 1846 QQLERQIQELRGRLGEED---AGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLV 1902
Query: 487 RMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLK 533
R A K V++Q +EE ++L +++EK + QLK
Sbjct: 1903 RRAEKRLKEVVLQ--------VEEERRVADQLRDQLEKGNLRVKQLK 1941
Score = 85.5 bits (210), Expect = 3e-16
Identities = 108/505 (21%), Positives = 202/505 (40%), Gaps = 34/505 (6%)
Query: 35 MVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAG 94
M + L + ++ L + + L LQ+ + ++ +L + L + E L LA
Sbjct: 1097 MEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALAR 1156
Query: 95 SKGADPPEFAALTKELNACREQLLEKEEE-----ISELKAERNNTRLLLEHLECLVSRHE 149
++ A L K L + L E +E+ ++ KAE+ R L E LE L E
Sbjct: 1157 AEDEGGAR-AQLLKSLREAQAALAEAQEDLESERVARTKAEKQR-RDLGEELEALRGELE 1214
Query: 150 RSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEEL 209
+L T +++ +S E EV + K+L E + + V+E + + + L E+L
Sbjct: 1215 DTLDSTNAQQELRS----KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQL 1270
Query: 210 AAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDST--DET 267
A + A + + ++ +++ S E Q+ L + D
Sbjct: 1271 EQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGE 1330
Query: 268 SQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIR 327
E E L++ E+ + S + E E + K+L TE Q ++
Sbjct: 1331 RARAEAAEKLQRAQAELENV-------SGALNEAESKTIRLSKELSSTEAQLHDAQELLQ 1383
Query: 328 EAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQE 387
E K + R+ +E + + ++ EL +A L + + +
Sbjct: 1384 EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAG 1443
Query: 388 RLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQE 447
LE E+ ++ R+AE L QR+A T+ +R +E R L+ +L++ +
Sbjct: 1444 ALEAGEEARRRAAREAEAL-------TQRLAEKTETVDR---LERGRRRLQQELDDATMD 1493
Query: 448 LQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKN 507
L++ RQ E+ ++ D+LL E + ++ER A E + + +
Sbjct: 1494 LEQQRQLVSTLEKKQRKF----DQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRA 1549
Query: 508 LEESLHDKERLAEEIEKLRSELDQL 532
LEE +E L + LR+EL+ L
Sbjct: 1550 LEEEQEAREELERQNRALRAELEAL 1574
Score = 61.6 bits (148), Expect = 5e-09
Identities = 110/501 (21%), Positives = 198/501 (39%), Gaps = 76/501 (15%)
Query: 17 QRGSQSSGSDSDSHFEQLM-------VNMLDERDRLLDTLRETQESLSLAQQRLQDVIYD 69
QR S+ F+QL+ + ++ER+R RE + + L++
Sbjct: 1497 QRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEA 1556
Query: 70 RDSLQRQLNSALPQDIESLTGGLAG-SKGADPPEFAALTKE--LNACREQLLEKEEEISE 126
R+ L+RQ N AL ++E+L K E A E N R Q+ E E+E++
Sbjct: 1557 REELERQ-NRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTA 1615
Query: 127 LKAERNNTRLLLE-HLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLF---- 181
+ + +L LE ++ L ++HER L Q + +G ++ K L+
Sbjct: 1616 AE----DAKLRLEVTVQALKTQHERDL-------QGRDEAGEERRRQLAKQLRDAEVERD 1664
Query: 182 --EHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA-LREQNVHIQ----------- 227
+ L R++L LE + A +E V LR+ ++
Sbjct: 1665 EERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRT 1724
Query: 228 -RKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQ 286
R+ S+ + L+G+E ++ L+ E+ + + N A
Sbjct: 1725 SREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAA 1784
Query: 287 MKERLAALSSRVGEVEQEAETA-----------RKDLIKTEEMNTKYQRD---IREAMAQ 332
+ E L R+G++E+E E RK L++ E + T+ + +A +
Sbjct: 1785 ILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESG 1844
Query: 333 KEDMEERITTLEKRYLSAQRESTSIHDMN-DKLENELANKEAILRQMEEKNRQLQERL-E 390
++ +E +I L R + + H M LE++LA E L Q E + R L +L
Sbjct: 1845 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQ-ETRERILSGKLVR 1903
Query: 391 LAEQKLQQTMRKAETLPEVEAELAQRIAA-----------LTKAEERHGNIEERMRHLEG 439
AE++L++ + + E V +L ++ L +AEE + R L+
Sbjct: 1904 RAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQR 1963
Query: 440 QLEEKNQELQRARQREKMNEE 460
+LE+ + E MN E
Sbjct: 1964 ELEDVTE------SAESMNRE 1978
Score = 52.8 bits (125), Expect = 2e-06
Identities = 72/310 (23%), Positives = 130/310 (41%), Gaps = 55/310 (17%)
Query: 42 RDRLLDTLRETQESLSLAQQ---RLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGA 98
R+ + RE+++ L + RLQ+ + D +RQ QD + + +A +
Sbjct: 1726 REEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQ----QDRDEMADEVANGNLS 1781
Query: 99 DPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 158
AA+ +E +L + EEE+ E E++N+ LL + L+ + E SL +
Sbjct: 1782 K----AAILEEKRQLEGRLGQLEEELEE---EQSNSELLNDRYRKLLLQVE-SLTTELSA 1833
Query: 159 RQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA 218
++ S S ++ + ++ L D R R +++ ++ALE +LA A +++
Sbjct: 1834 ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMT---IAALESKLAQAEEQL-- 1888
Query: 219 LREQNVHIQRKMASSEGSTESEHLEGMEPGQKVH--EKRLSNGSIDSTDETSQIVELQEL 276
E E E + G+ V EKRL + +E +L++
Sbjct: 1889 -------------------EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQ 1929
Query: 277 LEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDM 336
LEK N + Q+K +L E E+EA A+ + QR++ + E M
Sbjct: 1930 LEKGNLRVKQLKRQLE-------EAEEEASRAQAG-------RRRLQRELEDVTESAESM 1975
Query: 337 EERITTLEKR 346
+TTL R
Sbjct: 1976 NREVTTLRNR 1985
Score = 50.8 bits (120), Expect = 8e-06
Identities = 78/374 (20%), Positives = 158/374 (42%), Gaps = 59/374 (15%)
Query: 61 QRLQDVIYDRDSLQRQLNSA------LPQDIESLTGGLAGSKGADPPEFAALTKELNACR 114
++L+D +RD ++Q A L ++E L +A S G E +++ A
Sbjct: 1654 KQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMA-SAGQGKEEAVKQLRKMQAQM 1712
Query: 115 EQLLEKEEEI----SELKAERNNTRLLLEHLECLVSRHERSLRMTV-VKRQAQSPSGVSS 169
++L + EE E+ ++ + L+ LE V R + L + +RQAQ +
Sbjct: 1713 KELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMA 1772
Query: 170 EVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAA--ANQEIVALREQNVHIQ 227
+ + L+EK R R+ LEEEL +N E++ R + + +Q
Sbjct: 1773 D----EVANGNLSKAAILEEK-----RQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQ 1823
Query: 228 RKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELL-EKQNYEMAQ 286
+ ++E S E E G++ E+ QI EL+ L E+ A+
Sbjct: 1824 VESLTTELSAERSFSAKAESGRQQLER--------------QIQELRGRLGEEDAGARAR 1869
Query: 287 MKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKR 346
K +AAL S++ + E++ E ++ I + ++ + ++ ++E + Q E+ E R+
Sbjct: 1870 HKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEE-ERRVA----- 1923
Query: 347 YLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETL 406
D+L ++L ++Q++ + + +E A+ ++ R+ E +
Sbjct: 1924 ---------------DQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDV 1968
Query: 407 PEVEAELAQRIAAL 420
E + + + L
Sbjct: 1969 TESAESMNREVTTL 1982
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 95.5 bits (236), Expect = 3e-19
Identities = 147/707 (20%), Positives = 292/707 (41%), Gaps = 90/707 (12%)
Query: 32 EQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQ--DIESLT 89
E+ M M ++ +R + L ++ ++++ ++ +++ LQ Q+ S D E
Sbjct: 850 EKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERC 909
Query: 90 GGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHE 149
GL SK A KEL E+L E+EE SEL A++ N LE + R
Sbjct: 910 EGLIKSKIL----LEAKVKELT---ERLEEEEEMNSELVAKKRN----LEDKCSSLKRDI 958
Query: 150 RSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALE--- 206
L +T+ K + + + + +K+L E AL+E + +++ E+ S E
Sbjct: 959 DDLELTLTKVEKEKHATENK-------VKNLSEEMTALEENIS---KLTKEKKSLQEAHQ 1008
Query: 207 ---EELAAANQEIVALREQNVHIQRKMASSEGSTESEH--LEGMEPGQKVHEKRLSNGSI 261
++L ++ L + N ++++ EGS E E +E ++ E L
Sbjct: 1009 QTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE 1068
Query: 262 DSTDETSQIVELQELLEKQNYEMAQM--------------KERLAALSSRVGEVEQEAET 307
D + +++E L+K+ +E++Q+ ++++ L +R+ E+E+E E
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEA 1128
Query: 308 ARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENE 367
K E+ + R++ E E +EE + ++ M LE
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEI---SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEA 1185
Query: 368 LANKEAILRQMEEKNRQLQERLELAE-----QKLQQTMRKAETLPEVEA-ELAQRIAALT 421
EA + +K Q EL E Q+++Q + K ++ ++E ++A I AL+
Sbjct: 1186 TLQHEATAATLRKK--QADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 422 KAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQ 481
K++ NIE R +E Q E +A+ ++ H+ + RL T++ E L
Sbjct: 1244 KSK---SNIERTCRTVEDQFSE-----IKAKDEQQTQLIHDLNMQKA--RLQTQNGE-LS 1292
Query: 482 LHLKERMAALEE----KNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTG 537
++E+ + + + K L Q+ E ++ +EE K +A ++ R + D L+ +
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQY- 1351
Query: 538 SLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRT---TKVIRRPRRGRMGVRRDEPKVKS 594
+ AEL+ ++ + +RT T I+R ++ +++
Sbjct: 1352 --------EEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQE 1403
Query: 595 LGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQ 654
++ + L E+ D+ D E ++ L + + LA Q
Sbjct: 1404 AEENTETANSKCASLEKTKQRLQGEVEDL-MRDLERSHTACATLDKKQRNFDKVLAEWKQ 1462
Query: 655 E------QLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNL 695
+ +L+A KE R + E EE+ +++ ++ E NL
Sbjct: 1463 KLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNL 1509
Score = 87.0 bits (214), Expect = 1e-16
Identities = 136/734 (18%), Positives = 291/734 (39%), Gaps = 92/734 (12%)
Query: 25 SDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQ---LNSAL 81
S+ + E+ + + E+ L + ++T + L + + ++ +I L++Q L +L
Sbjct: 983 SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 82 PQ------DIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTR 135
Q D+E L G L + E+L +KE E+S+L+A+ ++ +
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ 1102
Query: 136 L--------------LLEHLECLVSRHERSLRMTVVKRQ---AQSPSGVSSEVEVLKALK 178
+ +E LE + E +LR + K++ A+ +S +E
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEA-EHTLRAKIEKQRSDLARELEEISERLEEASGAT 1161
Query: 179 SLFEHHKALDEKVRERLRVSLERVSALEEELAAANQE-----IVALREQNVHIQRKMASS 233
S E +++R LE + E AA ++ + L EQ ++QR
Sbjct: 1162 SAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKL 1221
Query: 234 EGSTESEHLEGMEPGQKVHEKRLSNGSIDST-----DETSQIVELQELLEKQNYEMAQMK 288
E +E + + S +I+ T D+ S+I E + +++ K
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK 1281
Query: 289 ERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERIT------- 341
RL + + +E E+ L K+++ T+ +++ M ++ + +
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSR 1341
Query: 342 ----TLEKRYLSAQRESTSIHDMNDKLENELA------NKEAILR--QMEEKNRQLQERL 389
L ++Y Q + K +E+A +AI R ++EE ++L +RL
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 390 ELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERH----GNIEERMRHLEGQLEEKN 445
+ AE+ + K +L + + L + L + ER ++++ R+ + L E
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 446 QELQRARQREKMNEEHNKRLS-----------DTVDRL--LTESNERLQLHLKERMAALE 492
Q+L ++ + ++ ++ LS + VD+L L N+ LQ + + +
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521
Query: 493 EKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTG---SLIEPTIPRTHL 549
E +QE+E +K +E+ D + EE+E + +R S ++ + R +
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVI 1581
Query: 550 DTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQ-QIGV 608
+ E+ ++ R + ++ + R D ++K + + N + Q+G
Sbjct: 1582 EKDEEIEQL------KRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGH 1635
Query: 609 LSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQ 668
+ E+ + + +++ D L + L+EQL + + L+
Sbjct: 1636 SNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNED---------LKEQLAIVERRNGLLL 1686
Query: 669 EEKESTELRAEEIE 682
EE E ++ E+ E
Sbjct: 1687 EELEEMKVALEQTE 1700
Score = 73.9 bits (180), Expect = 9e-13
Identities = 87/423 (20%), Positives = 190/423 (44%), Gaps = 44/423 (10%)
Query: 300 EVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTL--EKR--YLSAQREST 355
E E+E T ++D +T+E ++ + A+++++EE++ +L EK L Q E+
Sbjct: 848 EAEKEMATMKEDFERTKE-------ELARSEARRKELEEKMVSLLQEKNDLQLQVQSETE 900
Query: 356 SIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQ 415
++ D ++ E + +K IL +E K ++L ERLE E+ + + K L + + L +
Sbjct: 901 NLMDAEERCEGLIKSK--IL--LEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956
Query: 416 RI----AALTKAEERHGNIEERMRHLEGQLEEKNQELQR-ARQREKMNEEHNKRLSDTV- 469
I LTK E+ E ++++L ++ + + + ++++ + E H + L D
Sbjct: 957 DIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV 1016
Query: 470 --DRL--LTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESL-----------HD 514
D++ L + N +L+ + +LE++ L + E ++ LE L +D
Sbjct: 1017 EEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEND 1076
Query: 515 KERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKV 574
K+++ E+++K EL QL+ + E EL+ + L + T +
Sbjct: 1077 KQQIEEKLKKKEFELSQLQAKIDD--EQVHSLQFQKKIKELQARIEELEEEIEAEHTLRA 1134
Query: 575 IRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSS 634
+R + R E + L + + QI + E D+++ + ++
Sbjct: 1135 KIEKQRSDLA-RELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1193
Query: 635 MDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLN 694
L S A+ L EQ+D + + + +++EK ++ +++ + + ++S N
Sbjct: 1194 ATLRKKQADSVAE-----LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSN 1248
Query: 695 LAR 697
+ R
Sbjct: 1249 IER 1251
Score = 70.5 bits (171), Expect = 1e-11
Identities = 107/521 (20%), Positives = 227/521 (43%), Gaps = 70/521 (13%)
Query: 39 LDERDRLLD-TLRETQESLSLAQQRLQDVIYDRDSLQRQL---NSALPQDIESLTGGLAG 94
LD++ R D L E ++ L +Q L+ + SL +L +A + ++ L
Sbjct: 1446 LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRE 1505
Query: 95 SKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRM 154
+K E + LT+++ + L E E+ ++ E+++ ++ LE +E + HE S +
Sbjct: 1506 NKNLQE-EISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE-HEESKIL 1563
Query: 155 TVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQ 214
V +Q V SE++ + + E + +++ R R + S L+ E+ + N
Sbjct: 1564 RVQLELSQ----VKSELD-----RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 215 EIVALREQN-----VHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQ 269
+ ++ + IQ ++ + + +HL ++ K + L + + D Q
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ 1674
Query: 270 IVELQELLEKQN----YEMAQMKERLAAL--SSRVGEVEQEAETARKDLIKTEE---MNT 320
+ ++E++N E+ +MK L + R+ E E + R L+ ++ +NT
Sbjct: 1675 LA----IVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINT 1730
Query: 321 K--YQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQM 378
K + DI + A+ E+ + E++ A ++ + + K ++ A+ E + + +
Sbjct: 1731 KKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1790
Query: 379 EEKNRQLQERLELAEQ-----------KLQQTMRKAETLPEVEAELAQRIAALTKAEERH 427
E+ + LQ RL+ AEQ KL+ +R+ E E++ E + AL A +
Sbjct: 1791 EQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELEN--ELDVEQKRGAEALKGAHK-- 1846
Query: 428 GNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKER 487
E +++ + Q EE ++ + R L D VD+L +++ + ++
Sbjct: 1847 --YERKVKEMTYQAEEDHKNILR--------------LQDLVDKL----QAKVKSYKRQA 1886
Query: 488 MAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSE 528
A E+ N + + LEE+ + ++ KLR++
Sbjct: 1887 EEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927
Score = 68.9 bits (167), Expect = 3e-11
Identities = 71/349 (20%), Positives = 147/349 (42%), Gaps = 46/349 (13%)
Query: 210 AAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQ 269
A A +E+ ++E + ++A SE K L + E +
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEA----------------RRKELEEKMVSLLQEKN- 889
Query: 270 IVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREA 329
+LQ ++ + + +ER L +E + + + L + EEMN+ E
Sbjct: 890 --DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNS-------EL 940
Query: 330 MAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERL 389
+A+K ++E++ ++L++ + T + EN++ N + +EE +L +
Sbjct: 941 VAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK 1000
Query: 390 ELAEQKLQQTM-------RKAETLPEVEAELAQRI----AALTKAEERHGNIEERMRHLE 438
+ ++ QQT+ K L ++ A+L Q+ +L + ++ ++E R LE
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 439 GQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNE------RLQLHLKERMAALE 492
G L+ + + ++ EE K+ + +L + ++ + Q +KE A +E
Sbjct: 1061 GDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIE 1120
Query: 493 EKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIE 541
E I+ T R +E+ D LA E+E++ L++ T + IE
Sbjct: 1121 ELEEEIEAEHTLRAKIEKQRSD---LARELEEISERLEEASGATSAQIE 1166
Score = 63.5 bits (153), Expect = 1e-09
Identities = 111/581 (19%), Positives = 232/581 (39%), Gaps = 88/581 (15%)
Query: 3 CEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQR 62
C+++ E+ ++ Q + S ++S Q + + + L E ++ L+ QR
Sbjct: 1344 CDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA---QR 1400
Query: 63 LQDVIYDRDSLQRQLNSA------LPQDIESLTGGLAGSKGADPPEFAALTKELNACREQ 116
LQ+ + ++ + S L ++E L L S A A L K+ +
Sbjct: 1401 LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA----CATLDKKQRNFDKV 1456
Query: 117 LLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKA 176
L E ++++ E +AE LE + RSL + K + ++ EV+
Sbjct: 1457 LAEWKQKLDESQAE----------LEA-AQKESRSLSTELFKMR-------NAYEEVVDQ 1498
Query: 177 LKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGS 236
L++L +K L E++ + E+++ + L A + + ++ +Q + EGS
Sbjct: 1499 LETLRRENKNLQEEISDLT----EQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGS 1554
Query: 237 TESEHLEGMEPGQKVHEKR--LSNGSIDSTDETSQIVE--------LQELLE---KQNYE 283
E E + + ++ + + L I+ +E Q+ LQ +L+ + +
Sbjct: 1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 284 MAQMKERLAA----LSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEER 339
++K+++ + ++G ++ +K L + Q + +A+ ED++E+
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ 1674
Query: 340 ITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQ-- 397
+ +E+R N L EL + L Q E R ++ L A ++Q
Sbjct: 1675 LAIVERR--------------NGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLL 1720
Query: 398 --QTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQRE 455
Q T ++EA++AQ A + + + N EE+ + +EL++ +
Sbjct: 1721 HSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTS 1780
Query: 456 KMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESET------------ 503
E K L TV L +E QL LK +++ ++E E
Sbjct: 1781 AHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEA 1840
Query: 504 ------FRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGS 538
+ + ++E + E + I +L+ +D+L+ + S
Sbjct: 1841 LKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKS 1881
Score = 55.8 bits (133), Expect = 2e-07
Identities = 76/403 (18%), Positives = 168/403 (41%), Gaps = 36/403 (8%)
Query: 41 ERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADP 100
E+ L L E + SL + ++ V + ++ +L+ + + E + S+ A
Sbjct: 1540 EKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAE 1599
Query: 101 PEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 160
+ L E+ + + L K++ ++ + N + L H ++ ++ LR TV +
Sbjct: 1600 ALQSVLDAEIRSRNDALRLKKK----MEGDLNEMEIQLGHSNRQMAETQKHLR-TVQGQL 1654
Query: 161 AQSPSGVSSEV---EVLKALKSLFEHHKALDEKVRERLRVSLERVSAL----EEELAAAN 213
S + + E LK ++ E L + E ++V+LE+ E+EL A+
Sbjct: 1655 KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDAS 1714
Query: 214 QEIVALREQN---VHIQRKMASSEGSTESEHLEGMEPGQKVHEKR--------LSNGSID 262
+ L QN ++ ++K+ + ++E ++ + EK + +
Sbjct: 1715 DRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELK 1774
Query: 263 STDETSQIVE------------LQELL-EKQNYEMAQMKERLAALSSRVGEVEQEAETAR 309
+TS +E LQ L E + + K+++ L +RV E+E E + +
Sbjct: 1775 KEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQ 1834
Query: 310 KDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELA 369
K + + KY+R ++E Q E+ + I L+ Q + S ++ E +
Sbjct: 1835 KRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQAN 1894
Query: 370 NKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAE 412
+ + R+++ + + ER ++AE ++ + K+ + + E
Sbjct: 1895 TQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 95.1 bits (235), Expect = 4e-19
Identities = 106/560 (18%), Positives = 245/560 (43%), Gaps = 56/560 (10%)
Query: 43 DRLLDT---LRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGAD 99
++L+D + + Q LS +++L++ + + LQ QL+ Q E + +
Sbjct: 446 EKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ-----QALQQST 500
Query: 100 PPEFAALTKELNACREQLLEKEEEISELKA----ERNNTRLLLEHLECLVSRHERSLRMT 155
+ +L Q+ +K+++I L+A + N LL + E L ++ + T
Sbjct: 501 TAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Query: 156 VVKRQAQSPSGVSSE--VEVLKALKSLFEHHKALDEKVRER-------LRVSLERVSALE 206
V Q Q + E ++ + LK+ E HK E + ++ LR + +RV +LE
Sbjct: 561 AVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620
Query: 207 EELAAANQEIVALREQ----NVHIQRK---MASSEGSTESE------HLEGMEPGQKVHE 253
+ N ++ +E+ ++ I+ K + S+E + ++ HL+ + + +
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQ 680
Query: 254 KRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLI 313
+ L+ + T+++ + QE + + + KE+ +L + E+E + + D +
Sbjct: 681 QELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL 740
Query: 314 KTEEMNTKYQRDIREAMAQKEDMEERITTLEKRY-----------LSAQRESTSIHDMND 362
+ + + +D+++ D+E R T L K+ L Q++S ++ +
Sbjct: 741 EVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQ 800
Query: 363 KLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTK 422
KL + K+ + + E +++ + + E ++Q T+ + L +V+ E + L+
Sbjct: 801 KLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTE---LQKVKMEKEALMTELST 857
Query: 423 AEERHGNIEERMRHLEGQLEEKNQELQRA-RQREKMNEEHNKRLSDTVDRLLTESNERLQ 481
+++ + + +++ + + E++NQ+ + A EK +E +L ++ L E E +
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 482 LHLKERMAALEEK-------NVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKM 534
KE+ A+ + K LIQ T ++N +E + + E + + Q++
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977
Query: 535 RTGSLIEPTIPRTHLDTSAE 554
G L + +T L+ +
Sbjct: 978 LQGELKIAVLQKTELENKLQ 997
Score = 88.2 bits (217), Expect = 4e-17
Identities = 127/663 (19%), Positives = 289/663 (43%), Gaps = 81/663 (12%)
Query: 32 EQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGG 91
EQ + + E ++L L ET+ L A RL++ QRQL+S D E
Sbjct: 406 EQHGLQLQSEINQLHSKLLETERQLGEAHGRLKE--------QRQLSSEKLMDKEQ---- 453
Query: 92 LAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERS 151
+ A L +L+ EQL EK +EL+ + + T+ + + L
Sbjct: 454 ----------QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 152 LR--MTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEEL 209
LR +++ + +++ L+AL + + +L EK RE L ++ A E E
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYA---KIQAGEGET 560
Query: 210 AAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQ 269
A NQ L+E+N +Q ++ +++ + + +H++ + +
Sbjct: 561 AVLNQ----LQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQ-VQEQKAHLRAAQDR 615
Query: 270 IVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREA 329
++ L+ + + N ++ + KE+++ L +++ +A+T L+ E T
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQL-----DIQIKAKTEL--LLSAEAAKT--------- 659
Query: 330 MAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERL 389
AQ+ D++ + T + Q+E I D++ +L +K+ Q+E ++ +E+
Sbjct: 660 -AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY 718
Query: 390 ELAEQKLQQTMRKAETLP----EVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKN 445
EQK ++ + + L EV+A Q + L + + + ++E R L QLE +
Sbjct: 719 LSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEK 778
Query: 446 QELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFR 505
+ + R ++ + +++ + LT+ E Q+ LK+ L ++ + + E
Sbjct: 779 EIVSSTR----LDLQKKSEALESIKQKLTKQEEEKQI-LKQDFETLSQETKI--QHEELN 831
Query: 506 KNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDS 565
++ ++ + +++ E E L +EL +K + S + ++ + + E + +++D
Sbjct: 832 NRIQTTVTELQKVKMEKEALMTELSTVKDKL-SKVSDSLKNSKSEFEKENQKGKAAILDL 890
Query: 566 QSDYRTTKVIRRPRRGRM-GVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDID 624
+ +T K ++ + +M +++ ++K + E + Q+ + E++ +
Sbjct: 891 E---KTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKL----------ELNSM- 936
Query: 625 DDDRETIFSSMDLLSPSGHSDAQTLAMM--LQEQLDAINKEIRLIQEEKESTELRAEEIE 682
+E + + + L + + Q + L++ + K+I +Q E + L+ E+E
Sbjct: 937 ---QEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
Query: 683 NRV 685
N++
Sbjct: 994 NKL 996
Score = 85.1 bits (209), Expect = 4e-16
Identities = 130/733 (17%), Positives = 307/733 (41%), Gaps = 83/733 (11%)
Query: 17 QRGSQSSGSDSDSHFEQLMVNMLDERDRLLDT---LRETQESLSLAQQRLQDVIYDRDSL 73
Q+ + + ++ + EQ++ + D+ ++ + L++++E++SL ++ +D+ +
Sbjct: 497 QQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG 556
Query: 74 Q---------RQLNSALPQDIESLTGGLAGSKGADPPEFAALTKE-------LNACREQL 117
+ ++ N L + + LT L + L + L A ++++
Sbjct: 557 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 118 LEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKAL 177
L E ++EL ++ N ++ + L+ + L + AQ + AL
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676
Query: 178 KSLFEHHKALD---EKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSE 234
+ + + ++V +L+ E S LE L ++ ++L ++ ++ ++ E
Sbjct: 677 QDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLE 736
Query: 235 GSTESEHLEGMEPGQKVHEKRLSNGSID--STDETSQIVELQELLEKQNYEMAQMKERLA 292
+ + Q + ++R N ++ +T+ + Q+ +E++ ++ + E L
Sbjct: 737 ADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALE 796
Query: 293 ALSSRVGEVEQEAETARKDL--------IKTEEMNTKYQRDIREAMAQKEDMEERITTLE 344
++ ++ + E+E + ++D I+ EE+N + Q + E K + E +T L
Sbjct: 797 SIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856
Query: 345 KRYLSAQRESTSIHDMNDKLENE-LANKEAILR--------------QMEEKNRQLQERL 389
+ S S+ + + E E K AIL QME ++ +E
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 390 ELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQ 449
+ E++ + + + L ++ +L Q L + E+ ++ + L+ E+K ++++
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 450 RARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLE 509
+ K+ L + + + LT++ + L KE+++ L+ N + ETF K L+
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQLTQAAQELAAE-KEKISVLQ--NNYEKSQETF-KQLQ 1032
Query: 510 ESLHDKE-RLAEEIEKLRSELDQLKMRTGSLIE---------------PTIPRTHLDTSA 553
+ +E L + L+S ++L + LI T T SA
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 554 ELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLS--- 610
+ + + D + K ++ + ++ K+ + + + + ++I L+
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKE-----LVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147
Query: 611 -SHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQE 669
SH ES E++++ D + I ++L G +D+ A+ +++ N++I Q
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLEL---QGKADSLKAAVEQEKR----NQQILKDQV 1200
Query: 670 EKESTELRAEEIE 682
+KE EL+ E IE
Sbjct: 1201 KKEEEELKKEFIE 1213
Score = 78.2 bits (191), Expect = 5e-14
Identities = 85/399 (21%), Positives = 179/399 (44%), Gaps = 52/399 (13%)
Query: 174 LKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASS 233
L + LF+H++A+ + + ++ +++ QE+ L+ + K S
Sbjct: 50 LGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLK--EEKWYSE 107
Query: 234 EGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEK---QNYEMAQMKE- 289
E E E +G++ ++ +G + TD ++++ L++ LE+ +N+ + QMK+
Sbjct: 108 ELKKELEKYQGLQ-----QQEAKPDGLV--TDSSAELQSLEQQLEEAQTENFNIKQMKDL 160
Query: 290 ----------RLAALSSRVGEVEQEAETARKDLIK-TEEMNTKYQ--RDIREAMAQKEDM 336
+A + S+ E E A + + + TEE+N + +D++ + Q+ +
Sbjct: 161 FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220
Query: 337 EERI----------TTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQ 386
E+ T ++ L +RES + D KL+++ A+ EA + Q+ + +
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 387 ERLELAEQKLQQTMRKAETLPEVEAELAQRIAA----LTKAEERHGNIEERMRHLEGQLE 442
+ + + Q+LQ+ L + L + + TK EE+H ++++ L
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 340
Query: 443 EKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESE 502
+K+ + Q+ + R +E R+ L+E E Q LKE ++ +E K Q +
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVE----LSEKGEATQ-KLKEELSEVETK---YQHLK 392
Query: 503 TFRKNLEESLHDKE----RLAEEIEKLRSELDQLKMRTG 537
K L++ +KE +L EI +L S+L + + + G
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG 431
Score = 75.1 bits (183), Expect = 4e-13
Identities = 152/721 (21%), Positives = 298/721 (41%), Gaps = 138/721 (19%)
Query: 53 QESLSLAQQRLQDVIYDRDSLQRQ--LNSALPQDIESLTGGLAGSKGADPPEFAALTKEL 110
++ ++L +Q +QD+ + SL+ + + L +++E G L + + EL
Sbjct: 82 RDDVTLLRQEVQDL---QASLKEEKWYSEELKKELEKYQG-LQQQEAKPDGLVTDSSAEL 137
Query: 111 NACREQLLEKEEEISELKAERN----NTRLLLEHLECLVSRH--ERSLRMTVVKRQAQSP 164
+ +QL E + E +K ++ L + + S++ ERSLR ++ +
Sbjct: 138 QSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLT 197
Query: 165 SGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNV 224
++ E V++ LK+ R +E V+ L++EL V N+
Sbjct: 198 EELNKEATVIQDLKTELLQ------------RPGIEDVAVLKKELVQ-----VQTLMDNM 240
Query: 225 HIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEM 284
++R+ S + E + L+ + + I +L+ L K E+
Sbjct: 241 TLERERESEKLKDECKKLQSQYASSE-----------------ATISQLRSELAKGPQEV 283
Query: 285 AQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLE 344
A + L L S V E+ Q+ +T ++L+K E+ TK + E K++++ TL
Sbjct: 284 AVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQ---ATLH 340
Query: 345 KRYLSAQR-------ESTSIH----------DMNDKLENELANKEAILRQMEEKNRQLQE 387
++ L Q+ TS+H + KL+ EL+ E + ++ + +QLQ+
Sbjct: 341 QKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ 400
Query: 388 RLELAEQ--------------KLQQTMRK---------------AETLPEVEAELAQRIA 418
+ E EQ KL +T R+ +E L + E ++A
Sbjct: 401 QREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL 460
Query: 419 ALTKAEERHGNIEERMRHLEGQLEEKNQELQR---------ARQREKMN--EEHNKRLSD 467
L++ EE+ L+ QL++ Q+ Q A+ RE N E+ +++ D
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
Query: 468 ------TVDRLLTESNERLQLHLKERMAALEEKNVLIQ--ESETFRKN-LEESLHD-KER 517
++ LL +S E + L KER E+ IQ E ET N L+E H +E+
Sbjct: 521 KDQKIQNLEALLQKSKENISLLEKER----EDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
Query: 518 LAEEIEKLRSELDQLKMRTGSLIEPT-IPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIR 576
+ + EKL+++ + K +L + + HL + + V SL S ++ +
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQD---RVLSLETSVNELNSQLNES 633
Query: 577 RPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRE--TIFSS 634
+ + ++ + + + K + L E +T Q L +H DT + + D +E I +
Sbjct: 634 KEKVSQLDI-QIKAKTELLLSAEAAKTAQRADLQNH---LDTAQNALQDKQQELNKITTQ 689
Query: 635 MDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLN 694
+D ++ QE + ++ +E+ S E + EE+E ++ + + L
Sbjct: 690 LDQVTAKLQDK--------QEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLE 741
Query: 695 L 695
+
Sbjct: 742 V 742
Score = 66.2 bits (160), Expect = 2e-10
Identities = 104/496 (20%), Positives = 201/496 (40%), Gaps = 114/496 (22%)
Query: 32 EQLMVNMLDERDRLL---DTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESL 88
E LM + +D+L D+L+ ++ Q+ + I D + ++L L +E+
Sbjct: 849 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908
Query: 89 TGGLAGSKGADPPEFAA---LTKELNACREQLL---------EKEEE-----ISELKAER 131
K + E A L ELN+ +EQL+ EKEE+ I+ELK
Sbjct: 909 LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968
Query: 132 NNTRLLLEHLEC---LVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALD 188
+ +E L+ + + L + ++ Q+ +++E E + L++ +E +
Sbjct: 969 EQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETF 1028
Query: 189 EKVRE-------RLRVSLERVSALEEELAAANQEIVALREQ----NVHIQR----KMASS 233
++++ L + + + ++EE+L+ A +++++ R Q N IQ K
Sbjct: 1029 KQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 234 EGSTESEH--------LEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMA 285
+ S + E L+ ++ + + EK L N E S++ E++E+ +Q E+
Sbjct: 1089 QDSAKKEQQLQERCKALQDIQKEKSLKEKELVN-------EKSKLAEIEEIKCRQEKEIT 1141
Query: 286 QMKERLAA-----------------------------LSSRVGEVEQEAETAR--KDLIK 314
++ E L + S VEQE + KD +K
Sbjct: 1142 KLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK 1201
Query: 315 TEEMNTKYQRDIREA------------MAQKEDMEERIT-----------TLEKRYLSAQ 351
EE K + +EA M + E+ E ++T T++K + S+Q
Sbjct: 1202 KEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ 1261
Query: 352 RESTSIHDMNDKLENELANKEAILRQMEEKNRQLQER-------LELAEQKLQQTMRKAE 404
R + + D L E+A EA ++ +++ R L ER +E + K+ + RK +
Sbjct: 1262 RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLD 1321
Query: 405 TLPEVEAELAQRIAAL 420
EL + +L
Sbjct: 1322 NTTAAVQELGRENQSL 1337
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 95.1 bits (235), Expect = 4e-19
Identities = 142/652 (21%), Positives = 263/652 (40%), Gaps = 63/652 (9%)
Query: 51 ETQESLSLAQQRLQD---VIYDRDSLQRQLNSALPQDIESLTGGLAGSK--GADP-PEFA 104
E + L QQ+ + V ++D LQ QL AL + ++ G L K AD E
Sbjct: 675 ELELQLRSEQQKATEKERVAQEKDQLQEQLQ-ALKESLKVTKGSLEEEKRRAADALEEQQ 733
Query: 105 ALTKELNACREQLLEKEE-EISELKAERNNTRLLLEHLECLVSRHERS---LRMTVVKRQ 160
EL A L+E+ + E EL+ ER + L L+ L H+ LR + +
Sbjct: 734 RCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAM 793
Query: 161 AQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALR 220
A + S +++K + + E ++ ++ + + E++ L+EE A QE+ +
Sbjct: 794 AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
Query: 221 EQ----NVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQEL 276
E+ H + +++ + H Q+V EK + + D+ S + E
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKL--ADDLSTLQE---- 907
Query: 277 LEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDM 336
+MA + +A L + V + ++ ETA ++L+K R Q E +
Sbjct: 908 ------KMAATSKEVARLETLVRKAGEQQETASRELVK---------EPARAGDRQPEWL 952
Query: 337 EERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKL 396
EE+ +++ S Q ++ +++ NEL A L ME + +Q +ER + +
Sbjct: 953 EEQ---QGRQFCSTQAALQAMEREAEQMGNELERLRAAL--MESQGQQQEERGQQEREVA 1007
Query: 397 QQTMRKAETLPEVEAELAQRIA-------ALTKAEERHGNIEERMRHLEGQLEEKNQELQ 449
+ T + ++ E A R AL + ++E + H + E K+QEL
Sbjct: 1008 RLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELA 1067
Query: 450 RARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLE 509
+ R E + + L TV +L E+L KE + ++ +E LE
Sbjct: 1068 KLRGLEAAQIKELEELRQTVKQL----KEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE 1123
Query: 510 ESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDY 569
+ +L ++ +K + + D L+ SL R D++ E G L + +
Sbjct: 1124 ALRAEVSKLEQQCQKQQEQADSLER---SLEAERASRAERDSALETLQ--GQLEEKAQEL 1178
Query: 570 RTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRE 629
++ + + R + + S + EW G E++ + S I + E
Sbjct: 1179 GHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARG-----RQEAERKNSLISSLEEE 1233
Query: 630 TIFSSMDLLSPSGHS-DAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEE 680
+ +L G S + + L M E+ + + +RL+Q E S RA E
Sbjct: 1234 VSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285
Score = 92.0 bits (227), Expect = 3e-18
Identities = 145/674 (21%), Positives = 279/674 (41%), Gaps = 93/674 (13%)
Query: 46 LDTLRETQESLSL----AQQRLQDVIYDRDSLQRQLNSALPQ--DIESLTGGLAGSKGAD 99
L+ LR+ ESL++ ++ QD+ ++ + R++N + D+ A
Sbjct: 278 LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL 337
Query: 100 PPEFAALTKELNACREQLLEKEEEIS-ELKAERNNTRLLLEHLECL---VSRHERSLRMT 155
LT+E + ++ LEK+ ++ EL A + + L E E L +S+ E L
Sbjct: 338 QDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ- 396
Query: 156 VVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQE 215
+ Q V +V L+ LK A + +++ R+ + E +L A
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456
Query: 216 IVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQE 275
++Q + + SS S S+ E +E + H RL+ TS++ L
Sbjct: 457 FEEEKQQLSSLITDLQSSI-SNLSQAKEELEQASQAHGARLT---AQVASLTSELTTLNA 512
Query: 276 LLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKED 335
+++Q+ E+A +K++ +++ + Q+ E A + L E + ++ QKE
Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQ-------LSSSLKQKEQ 565
Query: 336 MEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQK 395
+ + EK+ + Q + + ++ E L ++A L+Q+E ++ +LE+ +Q+
Sbjct: 566 QLKEVA--EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQ 623
Query: 396 LQQTMRKAETLPEVEAELAQRIAA--LTKAEERHGNIE-ERMRHLEGQLEEKNQELQRAR 452
L Q +A + AQR A K EE +E R E Q + ELQ
Sbjct: 624 L-QVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRS 682
Query: 453 QREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESL 512
+++K E+ +R+ E ++ L+E++ AL+E + + +LEE
Sbjct: 683 EQQKATEK---------ERVAQEKDQ-----LQEQLQALKE------SLKVTKGSLEE-- 720
Query: 513 HDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTT 572
+K R A+ +E+ + + +LK T SL+E R
Sbjct: 721 -EKRRAADALEEQQRCISELKAETRSLVE-------------------------QHKRER 754
Query: 573 KVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQI------GVLSSHPFESDTEMSDIDDD 626
K + R GR G+ E +++ LG+ T+ + + + H ES+ E
Sbjct: 755 KELEEERAGRKGL---EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQL----- 806
Query: 627 DRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENR-V 685
+ + + + S +AQ M QEQL + +E ++E + + + IE+
Sbjct: 807 -VKEVAAWRERYEDSQQEEAQ-YGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSE 864
Query: 686 ASVSLEGLNLARVH 699
+S + LA +H
Sbjct: 865 LQISRQQNELAELH 878
Score = 87.8 bits (216), Expect = 6e-17
Identities = 128/549 (23%), Positives = 229/549 (41%), Gaps = 80/549 (14%)
Query: 49 LRETQESLSLAQQRLQDVIYDRDSLQRQLN----SALPQD--IESLTGGL---AGSKGAD 99
L + +S +Q+ Q DSL+R L S +D +E+L G L A G
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 100 PPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR 159
A+ +EL A R ++ + + E KA+ R E L+S E + +++ R
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV--SILNR 1239
Query: 160 QAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRV-----------SLERVSALEEE 208
Q G S E LK L +K+ ERLR+ + ER SAL EE
Sbjct: 1240 QVLEKEGESKE------LKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREE 1293
Query: 209 LAAANQEIVALREQNVHIQRKMASSEGSTE--SEHLEGMEPGQKVHEKRLSNGSIDSTDE 266
+ + +E R + ++++++ S E + L+ + E+ LS ++ T
Sbjct: 1294 VQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTST 1353
Query: 267 TSQIVEL-------QELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARK---DLIKTE 316
+ + EL Q+L +Q + +E L G + E A++ +LI
Sbjct: 1354 QALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLR 1413
Query: 317 EMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILR 376
+ + +R ++ A+K E+++ L+K + E+ + + + L E L
Sbjct: 1414 QKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFL---EVELD 1470
Query: 377 QMEEKN-RQLQERLELAEQKLQQTMRKAE-TLPEVEAELAQRIAALTKAEERHGNIEERM 434
Q EK ++L AE +L + R+A+ T E+E A+ A K E +E
Sbjct: 1471 QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530
Query: 435 RHLEGQLEEKNQELQRARQREKMNEEHNKRLSDT------------------------VD 470
+ L Q+E+ R++ K EE +K+L+D+
Sbjct: 1531 QKLTAQVEQLE---VFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
Query: 471 RLLTESNERLQLHLKERMAALEEKNVLIQESETF-------RKNLEESLHDKERLAEEIE 523
RL + NE LQ L ++ A E + +++++T + L+E L E+L +E +
Sbjct: 1588 RLQAQLNE-LQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENK 1646
Query: 524 KLRSELDQL 532
+LR+E ++L
Sbjct: 1647 ELRAEAERL 1655
Score = 68.6 bits (166), Expect = 4e-11
Identities = 132/626 (21%), Positives = 240/626 (38%), Gaps = 131/626 (20%)
Query: 39 LDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGA 98
L+ER RLL ET + + A +R + R+ +Q A Q + S + A
Sbjct: 1265 LEERLRLLQA--ETASNSARAAERSSAL---REEVQSLREEAEKQRVASENLRQELTSQA 1319
Query: 99 DPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 158
+ E L +EL A +E+ +KE+ +S L+ E +T+ L+ L L ++H
Sbjct: 1320 ERAE--ELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSEL--LPAKH---------- 1365
Query: 159 RQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA 218
+ L A +++ RE L S + L EL A +E+
Sbjct: 1366 -----------------LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGE 1408
Query: 219 L--REQNVHIQRKMASSEGSTESEHLEGMEPGQKVH----EKRLSNGSIDSTDETSQIVE 272
L Q V Q + A + ++ + E + +K H E+ G + VE
Sbjct: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE 1468
Query: 273 LQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDL-----------IKTEEMNTK 321
L + EK E+A ++ A +R+ EV++EA++ ++L +K E +
Sbjct: 1469 LDQAREKYVQELAAVR---ADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR 1525
Query: 322 YQRDIREAMAQKEDME----------------------------ERITTLEKRYLSAQRE 353
+Q + ++ AQ E +E +++ ++ + +Q+E
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE 1585
Query: 354 STSIHDMNDKLENELANKEAILR----QME----------EKNRQLQERLELAEQKLQQT 399
+ + ++L+ +L+ KE QME ++N++LQE+L EQ ++
Sbjct: 1586 AQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKEN 1645
Query: 400 MRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQEL------QRARQ 453
+ EL Q +AE+ ++ ++R LE Q+ +Q+L Q A
Sbjct: 1646 KELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATD 1705
Query: 454 REKMNEEHNK-RLSDTVDRLLTESNERLQLHLKERMAALEEKNVLI--QESETFRKNLEE 510
K E K +L ++D L E L + ++ + + + + + L
Sbjct: 1706 ALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLPP 1765
Query: 511 SLHDKERL------AEEIEKLRSELDQL--------------KMRTGSLIEPTIPR---- 546
+ E L A L S LD L + RT +I T+ +
Sbjct: 1766 KVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQIINITMTKKLDV 1825
Query: 547 THLDTSAELRYSVGSLVDSQSDYRTT 572
D++ YS S SQ+ R T
Sbjct: 1826 EEPDSANSSFYSTRSAPASQASLRAT 1851
Score = 59.3 bits (142), Expect = 2e-08
Identities = 100/500 (20%), Positives = 201/500 (40%), Gaps = 80/500 (16%)
Query: 253 EKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDL 312
+K S+ S ++ S + ++L+ ++M ++K++LA S E+E E RK L
Sbjct: 185 QKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLL 244
Query: 313 IKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDK--------- 363
++D + AM Q+ +R+ L ++ ++ E + ++ DK
Sbjct: 245 T---------EKDAQIAMMQQRI--DRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293
Query: 364 --------LENELANKEAILRQMEEKN--------------RQLQERL-ELAEQKLQQTM 400
L+ E + + + Q+ E+N +QLQ+ L EL E+ + T
Sbjct: 294 ETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQ 353
Query: 401 RKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQL--------EEKNQELQRAR 452
E ++E EL+ + EE++ ++ ++ LE L +EK + L
Sbjct: 354 EWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL 413
Query: 453 QREKMNEE------HNKRLSDTVDRLLTESNERLQLHLKERMAALEEK---NVLIQESET 503
Q E + +E +N +L V+ L TE ++ L ER EEK + LI + ++
Sbjct: 414 QLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQS 473
Query: 504 FRKNLEESLHDKE--------RLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAEL 555
NL ++ + E RL ++ L SEL L ++ + L A+
Sbjct: 474 SISNLSQAKEELEQASQAHGARLTAQVASLTSELTTL---NATIQQQDQELAGLKQQAKE 530
Query: 556 RYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGD-HEWNRTQQIGVLSSHPF 614
+ + + Q + + + + + +++ E ++K + + E R L++
Sbjct: 531 KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590
Query: 615 ESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQ---EQLDAINKEIRLIQEEK 671
E + + +R+ ++ L + + L LQ E D+ + Q EK
Sbjct: 591 EREASLR-----ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREK 645
Query: 672 ESTELRAEEIENRVASVSLE 691
+ EE++ V + E
Sbjct: 646 AELSRKVEELQACVETARQE 665
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 94.7 bits (234), Expect = 5e-19
Identities = 97/479 (20%), Positives = 208/479 (43%), Gaps = 54/479 (11%)
Query: 43 DRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNS---ALPQDIESLTGGLAGSKGAD 99
+ L + E QE L L + ++ L+R+L + LPQ+ G + +G
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQE-----GQVREQEGQV 61
Query: 100 PPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR 159
+ + ++ REQ + E+ +++ + R E V E +R +
Sbjct: 62 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR----EQEGQVREQEGQVREQ--EG 115
Query: 160 QAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVAL 219
Q + G E E +VRE+ E+ + E+ ++ +
Sbjct: 116 QVREQEGQVREQE----------------GQVREQEGQVREQEGQVREQEGQVREQEGQV 159
Query: 220 REQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDST--DETSQIVELQELL 277
REQ ++ + EG + + E +V E+ G + ++ Q+ E +E +
Sbjct: 160 REQEGQVREQ----EGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQM 215
Query: 278 EKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDME 337
+KQ +M + +E++ ++GE E++ + + + K EE K + +RE Q + E
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQE 275
Query: 338 ERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQ 397
E+ + Q+E T + + E ++ +E +R+ EE+ R+ +E++ E +
Sbjct: 276 EQ--------MLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE---E 324
Query: 398 QTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKM 457
Q ++ E + E + ++ ++ + K EE+ G EE+M+ E Q+ ++ +++++ ++ +
Sbjct: 325 QMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRK 384
Query: 458 NEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKE 516
EE ++ + + + E+ KE+M EE+ + ++ E RK E KE
Sbjct: 385 QEEQMRKQEEQMGEQKEQMGEQ-----KEQMREQEEQ--MGEQKEQMRKQEEHMGEQKE 436
Score = 82.0 bits (201), Expect = 3e-15
Identities = 90/435 (20%), Positives = 196/435 (45%), Gaps = 37/435 (8%)
Query: 104 AALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQS 163
A L +EL + E + I ELK + ++ L E V E +R + + Q
Sbjct: 14 AELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQ-EGQVREQEGQVREQEGQVREQE 72
Query: 164 PSGVSSEVEVLKALKSLFEHHKALDEK---VRERLRVSLERVSALEEELAAANQEIVALR 220
E +V + + E + E+ VRE+ E+ + E+ ++ +R
Sbjct: 73 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 132
Query: 221 EQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQ 280
EQ ++ + EG + + E +V E+ G + ++ Q+ E + + +Q
Sbjct: 133 EQEGQVREQ----EGQVREQEGQVREQEGQVREQE---GQV--REQEGQVREQEGQVREQ 183
Query: 281 NYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERI 340
++ + + ++ ++GE E++ + + K EE + + +R+ Q+E M E+
Sbjct: 184 EGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK---QEEQMGEQE 240
Query: 341 TTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQ---KLQ 397
++K+ Q++ + K E ++ +E +R+ EE+ + +E+ E EQ + +
Sbjct: 241 EQVQKQEEQVQKQEEQMR----KQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE 296
Query: 398 QTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKM 457
Q + E + E E ++ ++ + + EE+ G EE+M + Q+ E+ +++ +Q E+M
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW--KQEEQM 354
Query: 458 NEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKER 517
E+ + + E +E+M EE+ + ++ E RK E+ KE+
Sbjct: 355 GEQEEQ----------MQKQEEQVRKQEEQMRKQEEQ--MRKQEEQMRKQEEQMGEQKEQ 402
Query: 518 LAEEIEKLRSELDQL 532
+ E+ E++R + +Q+
Sbjct: 403 MGEQKEQMREQEEQM 417
Score = 32.7 bits (73), Expect = 2.2
Identities = 40/230 (17%), Positives = 94/230 (40%), Gaps = 10/230 (4%)
Query: 459 EEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERL 518
+E N L + + + TE +E +QLH+KE LE + + + R+ + + ++
Sbjct: 10 KEKNAELQEELQLVETEKSE-IQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQV 68
Query: 519 AEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRP 578
E+ ++R + Q++ + G + E + ++R G + + + R + R
Sbjct: 69 REQEGQVREQEGQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 126
Query: 579 RRGRM-----GVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFS 633
+ G++ VR E +V+ + Q+ E + ++ + + RE
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186
Query: 634 SMDLLSPSGHSDAQ--TLAMMLQEQLDAINKEIRLIQEEKESTELRAEEI 681
+ G + Q + EQ + + K+ + E++E + E++
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQM 236
>gi|110347443 TATA element modulatory factor 1 [Homo sapiens]
Length = 1093
Score = 93.6 bits (231), Expect = 1e-18
Identities = 106/472 (22%), Positives = 215/472 (45%), Gaps = 66/472 (13%)
Query: 119 EKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALK 178
E E E +E+ + +E L + + E L +++ K +A + + + +K
Sbjct: 432 EPAESQPEALSEKEDVCKTVEFLNEKLEKREAQL-LSLSKEKALLEEAFDNLKDEMFRVK 490
Query: 179 SLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGST- 237
+L ++ +R+ + ++V +E AA +EI ++E+ + ++ SSE +
Sbjct: 491 EESSSISSLKDEFTQRIAEAEKKVQLACKERDAAKKEIKNIKEE---LATRLNSSETADL 547
Query: 238 ---ESEHLEG-MEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAA 293
+ E + G ME G+K+ +++L N +I E + ++ K N ++ +++E L
Sbjct: 548 LKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKD-KENENMVAKLNKKVKELEEELQH 606
Query: 294 LSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRE 353
L + E+ + R+++ K M + ++D+ +++EE+ +++ SA +E
Sbjct: 607 LKQVLDGKEEVEKQHRENIKKLNSMVERQEKDLGRLQVDMDELEEKNRSIQAALDSAYKE 666
Query: 354 STSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAEL 413
T +H N ++E A + A+ R+M+ K +L LE A+++ +Q + ETL +L
Sbjct: 667 LTDLHKANAAKDSE-AQEAALSREMKAKE-ELSAALEKAQEEARQ---QQETLAIQVGDL 721
Query: 414 AQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLL 473
AL + E+ E+ +RH G+L+ QR ++ E N+E ++ +S T LL
Sbjct: 722 R---LALQRTEQAAARKEDYLRHEIGELQ------QRLQEAENRNQELSQSVSSTTRPLL 772
Query: 474 -------------TESNERLQLHLKER----------------------------MAALE 492
T S E+L+ +L +R M+++E
Sbjct: 773 RQIENLQATLGSQTSSWEKLEKNLSDRLGESQTLLAAAVERERAATEELLANKIQMSSME 832
Query: 493 EKNVLI-QESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPT 543
+N L+ QE+ F+ LE + +L +E + + EL+ LK +E T
Sbjct: 833 SQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKDEYVRTLEET 884
Score = 68.2 bits (165), Expect = 5e-11
Identities = 126/546 (23%), Positives = 221/546 (40%), Gaps = 75/546 (13%)
Query: 37 NMLDERDRLLDTLRETQESLSLAQQRLQDVIYD---RDSLQRQLNSALPQDIESLTGGLA 93
++L E+D + L E E LS Q ++I +D + + L + ++ L L
Sbjct: 546 DLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKENENMVAKLNKKVKELEEELQ 605
Query: 94 GSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLR 153
K Q+L+ +EE+ K R N ++ L +V R E+ L
Sbjct: 606 HLK-------------------QVLDGKEEVE--KQHREN----IKKLNSMVERQEKDLG 640
Query: 154 MTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAA- 212
V S + + A K L + HKA K E +L R +EEL+AA
Sbjct: 641 RLQVDMDELEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKEELSAAL 700
Query: 213 ---------NQEIVALREQNVHIQRKMASSEGSTESEHL--EGMEPGQKVHEKRLSN--- 258
QE +A++ ++ + + + + ++L E E Q++ E N
Sbjct: 701 EKAQEEARQQQETLAIQVGDLRLALQRTEQAAARKEDYLRHEIGELQQRLQEAENRNQEL 760
Query: 259 -GSIDSTDE--TSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQ-EAETARKDLIK 314
S+ ST QI LQ L Q ++++ LS R+GE + A ++
Sbjct: 761 SQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKN---LSDRLGESQTLLAAAVERERAA 817
Query: 315 TEE-MNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELAN-KE 372
TEE + K Q E +Q + + + + + S + + D N++ + EL N K+
Sbjct: 818 TEELLANKIQMSSME--SQNSLLRQENSRFQAQLESEKNRLCKLEDENNRYQVELENLKD 875
Query: 373 AILRQMEEKNRQ---LQERLELAEQKLQQTMRKA----ETLPEVEAELAQRIAALTKAEE 425
+R +EE ++ L +LE+ K++Q +KA ET+ E E + + T
Sbjct: 876 EYVRTLEETRKEKTLLNSQLEMERMKVEQERKKAIFTQETIKEKERKPFS--VSSTPTMS 933
Query: 426 RHGNIE-ERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESN--ERLQL 482
R +I M L+ +++ + ++ + L D V R+ S+ E LQ
Sbjct: 934 RSSSISGVDMAGLQTSFLSQDESHDHSFGPMPIS-ANGSNLYDAV-RMGAGSSIIENLQS 991
Query: 483 HLKERMAALEEKNVLIQESETFRKNLEESL-------HDKERLAEEIEKLRSELDQLKMR 535
LK R + + I E R + E L + E +EI KLR++L L R
Sbjct: 992 QLKLREGEITHLQLEIGNLEKTRSIMAEELVKLTNQNDELEEKVKEIPKLRTQLRDLDQR 1051
Query: 536 TGSLIE 541
++++
Sbjct: 1052 YNTILQ 1057
Score = 63.5 bits (153), Expect = 1e-09
Identities = 107/544 (19%), Positives = 218/544 (40%), Gaps = 86/544 (15%)
Query: 182 EHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEH 241
E + E+V E L + E E +A EQ + +EG T +
Sbjct: 371 ESAEGKSEEVNETLVIPTEEAEMEESGRSATPVNC----EQPDILVSSTPINEGQTVLDK 426
Query: 242 L-EGMEPGQKVHEKRLSNGSIDSTDETSQIVE-LQELLEKQNYEMAQMKERLAALSSRVG 299
+ E EP + E ++ ++ + VE L E LEK+ ++ + + A L
Sbjct: 427 VAEQCEPAESQPE------ALSEKEDVCKTVEFLNEKLEKREAQLLSLSKEKALL----- 475
Query: 300 EVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHD 359
E+ + + ++ + +E ++ + K++ +RI EK+ A +E +
Sbjct: 476 --EEAFDNLKDEMFRVKEESSSIS-------SLKDEFTQRIAEAEKKVQLACKERDAAKK 526
Query: 360 MNDKLENELA---NKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQR 416
++ ELA N ++EK+ Q++ +E E+ +Q + + + ++ A+ +
Sbjct: 527 EIKNIKEELATRLNSSETADLLKEKDEQIRGLMEEGEKLSKQQLHNSNIIKKLRAKDKEN 586
Query: 417 IAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTES 476
+ K ++ +EE ++HL+ L+ K + EK + E+ K+L+ V+R +
Sbjct: 587 ENMVAKLNKKVKELEEELQHLKQVLDGKEEV-------EKQHRENIKKLNSMVERQEKDL 639
Query: 477 NERLQLHLKERMAALEEKNVLIQ--------------------ESETFRKNLEESLHDKE 516
RLQ+ + E LEEKN IQ +SE L + KE
Sbjct: 640 G-RLQVDMDE----LEEKNRSIQAALDSAYKELTDLHKANAAKDSEAQEAALSREMKAKE 694
Query: 517 RLAEEIEKLRSELDQ----LKMRTGSLIEPTIPRTHLDTSAE---LRYSVGSLVDSQSDY 569
L+ +EK + E Q L ++ G L + RT + + LR+ +G L
Sbjct: 695 ELSAALEKAQEEARQQQETLAIQVGDL-RLALQRTEQAAARKEDYLRHEIGEL------- 746
Query: 570 RTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRE 629
+R + R++ +S+ +QI L + + ++ + +
Sbjct: 747 --------QQRLQEAENRNQELSQSVSSTTRPLLRQIENLQATLGSQTSSWEKLEKNLSD 798
Query: 630 TIFSSMDLLSPSGHSDAQTLAMMLQE--QLDAINKEIRLIQEEKESTELRAEEIENRVAS 687
+ S LL+ + + +L Q+ ++ + L+++E + + E +NR+
Sbjct: 799 RLGESQTLLAAAVERERAATEELLANKIQMSSMESQNSLLRQENSRFQAQLESEKNRLCK 858
Query: 688 VSLE 691
+ E
Sbjct: 859 LEDE 862
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 93.6 bits (231), Expect = 1e-18
Identities = 128/544 (23%), Positives = 228/544 (41%), Gaps = 87/544 (15%)
Query: 18 RGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQ--- 74
RG+ ++ E+ V++ E++ L L+ Q++L+ A++R +I + L+
Sbjct: 909 RGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKV 968
Query: 75 RQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNT 134
++L+ L +D E + LA + E L K+++ + L + E+E +A N
Sbjct: 969 KELSERL-EDEEEVNADLAARRRKLEDECTELKKDIDDLKLTLAKAEKE---KQATENKV 1024
Query: 135 RLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRER 194
+ L E + L E R+T K+ Q H +AL + E
Sbjct: 1025 KNLTEEMAAL---DESVARLTKEKKALQEA------------------HQQALGDLQAEE 1063
Query: 195 LRVSLERVSALE-----EELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQ 249
RVS + L E+L + ++ LR +RK+ T+ + + Q
Sbjct: 1064 DRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAAQDKQ 1123
Query: 250 KVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETAR 309
++ EK + S++ +L +E + AQM++++ L +R E+E+E E R
Sbjct: 1124 QLEEKLKK--------KDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAER 1175
Query: 310 KDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELA 369
+ E+ + R++ E E +EE + ++ + + +LE
Sbjct: 1176 AARARVEKQRAEAARELEEL---SERLEEAGGASAGQREGCRKREAELGRLRRELEEAAL 1232
Query: 370 NKEAILRQMEEKNRQLQERLELAEQ-----KLQQTMRKAETLPEVEAE-LAQRIAALTKA 423
EA + + K Q + EL EQ +++Q + K ++ +E + LA + LT+A
Sbjct: 1233 RHEATVAALRRK--QAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRA 1290
Query: 424 EERHGNIEERMRHLEGQLEE---KNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERL 480
+ + E+ R E QL E K +ELQR ++ + +R RL TES E
Sbjct: 1291 K---ASAEKLCRTYEDQLSEAKIKVEELQR-----QLADASTQR-----GRLQTESGELS 1337
Query: 481 QLHLKERMAALEEKNVLI-----------QESETFRKNLEESLHDKERLAEEIEKLRSEL 529
+L LEEK LI Q E R+ LEE K LA ++ LR +
Sbjct: 1338 RL--------LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDC 1389
Query: 530 DQLK 533
D L+
Sbjct: 1390 DLLR 1393
Score = 65.1 bits (157), Expect = 4e-10
Identities = 102/524 (19%), Positives = 210/524 (40%), Gaps = 53/524 (10%)
Query: 47 DTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAAL 106
D LRE E + AQ LQ ++ ++ Q S D T L +K
Sbjct: 1390 DLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEA 1449
Query: 107 TKELNACREQLLEKEEEISELKAERNNTRLLLE--------------HLECLVS---RHE 149
+ + A + E+ L+ E + L LE HLE + R E
Sbjct: 1450 EEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQE 1509
Query: 150 RSLRMTVVKRQAQSPSGVSSEV--------EVLKALKSLFEHHKALDEKVRERLRVSLER 201
++ + Q +S G+ +E+ E L+AL++L +K L E++ + ++
Sbjct: 1510 EEMQRELEAAQRES-RGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLT----DQ 1564
Query: 202 VSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGM-----------EPGQK 250
VS + + + AL + IQ + +EG+ E E + + E +K
Sbjct: 1565 VSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRK 1624
Query: 251 VHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARK 310
+ EK ++ + + + LQ L+ + + + + ++E + A +
Sbjct: 1625 LAEKDEECANLRRNHQRA-VESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATR 1683
Query: 311 DLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELAN 370
+ + Q ++E A +++ + L ++ + +R ++ + ++L L
Sbjct: 1684 QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQ 1743
Query: 371 KEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNI 430
E R E++ + ERL L + + + + L EA+LAQ + +A +
Sbjct: 1744 GERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKL---EADLAQLSGEVEEAAQERREA 1800
Query: 431 EERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAA 490
EE+ + +EL ++E+ H +R+ T+++ + E RL+ + AA
Sbjct: 1801 EEKAKKAITDAAMMAEEL----KKEQDTSAHLERMKKTLEQTVRELQARLE---EAEQAA 1853
Query: 491 LEEKNVLIQESETFRKNLEESLH-DKERLAEEIEKLRSELDQLK 533
L +Q+ E + LE L ++++ AE ++ +R ++K
Sbjct: 1854 LRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVK 1897
Score = 63.9 bits (154), Expect = 9e-10
Identities = 130/692 (18%), Positives = 274/692 (39%), Gaps = 91/692 (13%)
Query: 210 AAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQ 269
A A +E+ ALR + ++ +A++E + L + T E +
Sbjct: 892 AQAEEELAALRAELRGLRGALAAAEAKRQE----------------LEETHVSITQEKND 935
Query: 270 IVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREA 329
+ LQ E+ N +A +ER L ++E + + + L EE+N R+
Sbjct: 936 LA-LQLQAEQDN--LADAEERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKL 992
Query: 330 MAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERL 389
+ ++++ I L+ A++E + + L E+A + + ++ ++ + LQE
Sbjct: 993 EDECTELKKDIDDLKLTLAKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAH 1052
Query: 390 ELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQ 449
+ + L +++AE R++ALTKA+ R +E+++ LE LE++ ++L+
Sbjct: 1053 Q-------------QALGDLQAE-EDRVSALTKAKLR---LEQQVEDLECSLEQE-KKLR 1094
Query: 450 RARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLE 509
+R K E + +L+ + ++L+ LK++ + L + ++ +++ + ++
Sbjct: 1095 MDTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQ 1154
Query: 510 ESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDY 569
+ + + + AEE+E+ ++ + + + + EL L ++
Sbjct: 1155 KKIKELQARAEELEE--------ELEAERAARARVEKQRAEAARELEELSERLEEAGGAS 1206
Query: 570 RTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRE 629
+ R R +G R E + +L HE + L E E+ + D +
Sbjct: 1207 AGQREGCRKREAELGRLRRELEEAAL-RHE----ATVAALRRKQAEGAAELGE-QVDSLQ 1260
Query: 630 TIFSSMDLLSPSGHSDAQTLAMMLQEQLDA---INKEIRLIQEEKESTELRAEEIENRVA 686
+ ++ + LA ++ A K R +++ +++ EE++ ++A
Sbjct: 1261 RVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLA 1320
Query: 687 SVS-------LEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREMDRM 739
S E L+R+ S + A ++ +L S A+
Sbjct: 1321 DASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAH 1380
Query: 740 GVMTLPSD---LRKHRRKIAVVEEDGREDKATIKCETS---PPPTPRALRMTHTLPSSYH 793
V L D LR+ + A + + + + E + A++ T L
Sbjct: 1381 AVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEEL----- 1435
Query: 794 NDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKS-----------SIGRLFGKK- 841
+A+ L++ L+ G+ +AN+ SL KA + +S S KK
Sbjct: 1436 EEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQ 1495
Query: 842 -------EKARLGQLRGFMETEAAAQESLGLG 866
E+ R + E EAA +ES GLG
Sbjct: 1496 RHLERALEERRRQEEEMQRELEAAQRESRGLG 1527
Score = 61.2 bits (147), Expect = 6e-09
Identities = 95/457 (20%), Positives = 183/457 (40%), Gaps = 59/457 (12%)
Query: 51 ETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKEL 110
E E+L + LQ+ I D Q L+ Q++E L G K L
Sbjct: 1542 EALETLKRENKNLQEEISDLTD-QVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGAL 1600
Query: 111 NACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSE 170
+ L + E+S++KAE + +L + EC R R+ + V QA + +
Sbjct: 1601 ELEETKTLRIQLELSQVKAEVDR-KLAEKDEECANLR--RNHQRAVESLQASLDAETRAR 1657
Query: 171 VEVLKALKSLFEHHKALDEKVRERLRVSLERVSA-------LEEELAAANQE---IVALR 220
E L+ K + L+ ++ R + E +A L+EE A ++E L
Sbjct: 1658 NEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELH 1717
Query: 221 EQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQ 280
EQ ++R+ AS + E +E G++ +RL+ E + E LL Q
Sbjct: 1718 EQAQALERR-ASLLAAELEELRAALEQGER--SRRLAE------QELLEATERLNLLHSQ 1768
Query: 281 NYEMAQMKERLAA-LSSRVGEVEQEAETARKDLIKT------------------------ 315
N + K++L A L+ GEVE+ A+ R+ K
Sbjct: 1769 NTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHL 1828
Query: 316 EEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAIL 375
E M ++ +RE A+ E+ E+ K+ + Q+ + ++ +L+ E L
Sbjct: 1829 ERMKKTLEQTVRELQARLEEAEQAALRGGKKQV--QKLEAKVRELEAELDAEQKKHAEAL 1886
Query: 376 RQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMR 435
+ + + R+++E AE+ + R + + ++++++ +AE++ + R
Sbjct: 1887 KGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYR 1946
Query: 436 HLEGQLEEKNQELQ---------RARQREKMNEEHNK 463
+ +L++ + RAR R+ + +H +
Sbjct: 1947 KAQHELDDAEERADMAETQANKLRARTRDALGPKHKE 1983
Score = 53.5 bits (127), Expect = 1e-06
Identities = 72/347 (20%), Positives = 133/347 (38%), Gaps = 17/347 (4%)
Query: 39 LDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGA 98
L E+D LR + + Q D + +L + D+ L L G
Sbjct: 1625 LAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQL-GHATR 1683
Query: 99 DPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVK 158
E A T+ + A ++ +E L AE + LE L++ LR + +
Sbjct: 1684 QATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQ 1743
Query: 159 RQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVA 218
+ +E + L L + L + +++L L ++S EE A +E
Sbjct: 1744 GERSRRLAEQELLEATERLNLLHSQNTGLLNQ-KKKLEADLAQLSGEVEEAAQERREAEE 1802
Query: 219 LREQNVHIQRKMASS--EGSTESEHLEGMEPG------------QKVHEKRLSNGSIDST 264
++ + MA + S HLE M+ ++ + L G
Sbjct: 1803 KAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQ 1862
Query: 265 DETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQR 324
+++ EL+ L+ + + A+ + + RV E+ +AE RK+L + +++ K Q
Sbjct: 1863 KLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQS 1922
Query: 325 DIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANK 371
++ Q E+ E++ T +Y AQ E + D E + ANK
Sbjct: 1923 KVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQ-ANK 1968
Score = 52.8 bits (125), Expect = 2e-06
Identities = 83/417 (19%), Positives = 172/417 (41%), Gaps = 62/417 (14%)
Query: 41 ERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADP 100
E+ + L E + +L L + + + + ++ +++ L + E + A
Sbjct: 1585 EKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVE 1644
Query: 101 PEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 160
A+L E A E L K++ ++ + N+ L L H + + + R+ Q
Sbjct: 1645 SLQASLDAETRARNEALRLKKK----MEGDLNDLELQLGHATRQATEAQAATRLM----Q 1696
Query: 161 AQSPSGVSSEVEVLKALKSLFEHHKALDEKVR------ERLRVSLERVSA----LEEELA 210
AQ + E + L E +AL+ + E LR +LE+ E+EL
Sbjct: 1697 AQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELL 1756
Query: 211 AANQEIVALREQNVHI--QRK-----MASSEGSTESEHLEGMEPGQKVHEKRLSNGSI-- 261
A + + L QN + Q+K +A G E E E +K +K +++ ++
Sbjct: 1757 EATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKA-KKAITDAAMMA 1815
Query: 262 ----DSTDETSQIVELQELLEK---------QNYEMAQM---KERLAALSSRVGEVEQEA 305
D ++ + +++ LE+ + E A + K+++ L ++V E+E E
Sbjct: 1816 EELKKEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAEL 1875
Query: 306 ETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLE 365
+ +K + + K++R ++E Q E+ + + ++ D+ DKL+
Sbjct: 1876 DAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQ--------------DLVDKLQ 1921
Query: 366 NELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTK 422
+++ ++ RQ EE +Q L +K Q + AE ++ A ++ A T+
Sbjct: 1922 SKV---KSYKRQFEEAEQQANTNL-AKYRKAQHELDDAEERADMAETQANKLRARTR 1974
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 92.8 bits (229), Expect = 2e-18
Identities = 118/571 (20%), Positives = 239/571 (41%), Gaps = 63/571 (11%)
Query: 42 RDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQ--RQLNSALPQDIESLTGGLAGSKGAD 99
R LL+ R+ +E ++ QD ++ + + R+ + L ++ E L
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ---------- 261
Query: 100 PPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR 159
E +EL EQL + E + EL+ ER + L R E+ LR +
Sbjct: 262 -EEEPQRQRELQEEEEQLRKLERQ--ELRRERQEEEQQQQRL-----RREQQLRRKQEEE 313
Query: 160 QAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVAL 219
+ + + E + + E +++ R ++ E+ E+ QE
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQE-EER 372
Query: 220 REQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEK 279
REQ + ++++ + + L + ++ + R Q+ Q+L +
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ----QLRREQQLRREQQLRRE 428
Query: 280 QNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEER 339
Q E + K R+ ++E R+D +K EE +++++ R+ +++ EER
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEE----RRDWLKREEETERHEQERRKQQLKRDQEEER 484
Query: 340 ITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQT 399
+R+L + E ++ E + ++ + R+ EE+ Q +R E E++LQQ
Sbjct: 485 ----RERWLKLEEE--------ERREQQERREQQLRREQEERREQRLKRQE-EEERLQQR 531
Query: 400 MRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQEL---QRARQREK 456
+R + L + E +++ L + EE+ E R + L+ + EE+ +L + R++++
Sbjct: 532 LRSEQQLRREQEERREQL--LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR 589
Query: 457 MNEEHNKRLS-----DTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEES 511
+ E +RL + V+RL E ER + LK E + L++ E + ++
Sbjct: 590 LKREQEERLEQRLKREEVERL--EQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQL 647
Query: 512 LHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHL--DTSAELRYSVGSLV------ 563
+++ E+ K E ++L+ R E L + + R + S +
Sbjct: 648 RREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQ 707
Query: 564 -DSQSDYRTTKVIRRPRRGRMGVRRDEPKVK 593
+S++D R +KV RPR+ RR E + K
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Score = 88.2 bits (217), Expect = 4e-17
Identities = 126/578 (21%), Positives = 233/578 (40%), Gaps = 68/578 (11%)
Query: 115 EQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEV--- 171
E+ EK+E + + +R + L + E R ER + Q QS G +E
Sbjct: 152 EEQSEKQERLEQRDRQRRDEELWRQRQEWQ-EREERRAE----EEQLQSCKGHETEEFPD 206
Query: 172 -EVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKM 230
E L+ + L K +EK ++R R +RV EEE +E V +E+ K+
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQR-RERQDRVFQEEEEKEWRKRETVLRKEEE-----KL 260
Query: 231 ASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKER 290
E + E E E +K+ + L + + ++ Q+L KQ E + +E
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE- 319
Query: 291 LAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSA 350
E ++ E + + E+ + Q + RE ++E EER +R
Sbjct: 320 ---------ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 351 QRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVE 410
+R + + +E LR+ ++ R+ Q R E ++ QQ R+ + E E
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430
Query: 411 AELAQRIAALTKAEER-HGNIEERMRHLEGQLEEKNQELQRARQREKMN--EEHNKRLSD 467
E ++ + E+R EER L+ + E + E +R +Q+ K + EE +R
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLK 490
Query: 468 TVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRS 527
+ E ER + L+ E+ + QE E + L++ L +++L E E+ R
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEE---ERLQQRLRSEQQLRREQEERRE 547
Query: 528 ELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRR 587
+L LK +E L E R L+ + + R + ++R + R+ R
Sbjct: 548 QL--LKREEEKRLEQERREQRLKREQEERRD--QLLKREEERRQQR-LKREQEERLEQRL 602
Query: 588 DEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQ 647
+V+ L + E R Q++ + + +++ R+ + S
Sbjct: 603 KREEVERL-EQEERREQRL------------KREEPEEERRQQLLKS------------- 636
Query: 648 TLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRV 685
+EQ + +++R Q+E+ L+ EE E R+
Sbjct: 637 ------EEQEERRQQQLRREQQERREQRLKREEEEERL 668
Score = 77.0 bits (188), Expect = 1e-13
Identities = 95/439 (21%), Positives = 190/439 (43%), Gaps = 49/439 (11%)
Query: 115 EQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVL 174
++ L +EEE + + +R L+ LE E+ R ++ + G+ + E
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLE----EEEQLQRRERAQQLQEEEDGLQEDQERR 863
Query: 175 KALKSLFEHHKALD-EKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASS 233
++ + + E+ R+R R +L AL+E+L Q L+E+ +QR+
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ---LLQEEEEELQRE---- 916
Query: 234 EGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAA 293
E E E ++ E +E Q E Q L E++ Q +ER
Sbjct: 917 ----EREKRRRQEQERQYRE-----------EEQLQQEEEQLLREEREKRRRQERERQYR 961
Query: 294 LSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRE 353
++ + E++ + + +E KY+ + E + Q+E+ R ++R +R+
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREE--EELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 354 STSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAE---------------QKLQQ 398
++ + E +L +E R+++E+ RQ +E EL + Q+L++
Sbjct: 1020 YRKKDELQQE-EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 399 TMRKAETLPEVEAELAQRIAALTKAEERHGNI--EERMRHLEGQLEEKNQELQRARQREK 456
RK E L + E +L + + +ER EE ++ E QL + +E +R ++ E+
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 457 MNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKE 516
E + + ++LL E E+ + ER EE+ + +E + R+ E+ ++E
Sbjct: 1139 QYRE-EEEVQQEEEQLLREEPEKRRRQELERQYR-EEEELQQEEEQLLREEQEKRRQERE 1196
Query: 517 RLAEEIEKLRSELDQLKMR 535
R E E+L+ + + + R
Sbjct: 1197 RQYREEEELQRQKRKQRYR 1215
Score = 76.3 bits (186), Expect = 2e-13
Identities = 115/577 (19%), Positives = 232/577 (40%), Gaps = 105/577 (18%)
Query: 115 EQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVL 174
+QLL +E E E + + R E + L R E+ LR RQ + E+
Sbjct: 1318 KQLLREERE--EKRRRQETDRKFREEEQLLQEREEQPLR-----RQERDRKFREEELRHQ 1370
Query: 175 KALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSE 234
+ + E + L + RER L+EE QE REQ + R E
Sbjct: 1371 EQGRKFLEEEQRLRRQERER--------KFLKEEQQLRCQE----REQQLRQDRDRKFRE 1418
Query: 235 GSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAAL 294
E + L E +K E+ + + + +E ++ L ++ + + +E+L L
Sbjct: 1419 ---EEQQLSRQERDRKFREEEQQ---VRRQERERKFLEEEQQLRQERHRKFREEEQL--L 1470
Query: 295 SSRVGEVEQEAETARKDLIKTEEMNTKYQ-RDIREAMAQKEDMEERITTLEKRYLSAQRE 353
R + E RK L + +++ + + R RE + ++ E + E++ QR+
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 354 STSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAEL 413
+ + E +L +E ++ ++++R+ +E +L +++ +Q + + E
Sbjct: 1531 RKFLQE-----EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE--------- 1576
Query: 414 AQRIAALTKAEERHGNIEE---RMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVD 470
+R +EE R + E + E Q+L+R ++++ +E +++ + D
Sbjct: 1577 ----------RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE--D 1624
Query: 471 RLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESL-HDKERLAEEIEKLRSEL 529
L + E QLH +ER ++ L +E + R+ E+ L HD++R E E+L E
Sbjct: 1625 EQLLQEREEQQLHRQER-----DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679
Query: 530 DQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDE 589
++ ++R R D R+ R +RR E
Sbjct: 1680 EEQQLR----------RQERD-------------------------RKFREEEQQLRRQE 1704
Query: 590 PKVKSLGDHEWNRTQQI--GVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQ 647
+ K L + + R Q++ +TE + +R + L P
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ-- 1762
Query: 648 TLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENR 684
+ +++ D +E +++E+E +LR++E + +
Sbjct: 1763 ---QLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
Score = 75.9 bits (185), Expect = 2e-13
Identities = 125/567 (22%), Positives = 223/567 (39%), Gaps = 72/567 (12%)
Query: 17 QRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQ 76
+R Q + + +QL+ + R + L RE +E L +QRL+ +R + +
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLK--REQEERL---EQRLKREEVERLEQEER 615
Query: 77 LNSALPQDI--ESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNT 134
L ++ E L S+ + L +E REQ L++EEE ER
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE-----EERLEQ 670
Query: 135 RLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKV--R 192
RL EH E ER + + Q Q+ + S + K L A KV R
Sbjct: 671 RLKREHEE------ERREQELAEEEQEQARERIKSRIP--KWQWQLESEADARQSKVYSR 722
Query: 193 ERLRVSLERVSALEEELAAANQEIVALREQNVHIQRK------------MASSEGSTESE 240
R + R EE+ E+ E+ H Q++ A + +
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 241 HLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGE 300
L P ++ E++L + + + + +E E++ + + ++ L L E
Sbjct: 783 RLSARPPLREQRERQLR--AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE----E 836
Query: 301 VEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYL---------SAQ 351
EQ R ++ EE + ++ R + Q+ D + R E+R + Q
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 352 RESTSIHDMNDKLENELANKEAILRQMEEKNRQL--QERLELAEQKLQQTMRKAETLPEV 409
+ + + E EL +E R+ +E+ RQ +E+L+ E++L + R+ E
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER 956
Query: 410 EAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKR----- 464
E + + K E+ G E+ R E + + + +E + + + + EE KR
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 465 ---------LSDTVDRLLTESNERLQLHLKERM------AALEEKNVLIQESETFRK-NL 508
L ++LL E E+ +L +ER EE+ +L +E ET R+ L
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 509 EESLHDKERLAEEIEKLRSELDQLKMR 535
E +E L +E E+L E + + R
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRR 1103
Score = 70.1 bits (170), Expect = 1e-11
Identities = 112/497 (22%), Positives = 204/497 (41%), Gaps = 38/497 (7%)
Query: 41 ERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADP 100
E+ R + R+ +E L Q+ Q + +R+ +RQ + + L G +P
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEP 978
Query: 101 PEFAALTKELNACREQLLEKEEEISELKAERNNTRLL-----LEHLECLVSRHERSLRMT 155
+ +E E+ L++EEE L+ ER R + L E+ LR
Sbjct: 979 EKRRRQEREKKYREEEELQQEEE-QLLREEREKRRRQEWERQYRKKDELQQEEEQLLREE 1037
Query: 156 VVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQE 215
KR+ Q E E L+ E + L E+ R R LER EEEL ++
Sbjct: 1038 REKRRLQERERQYREEEELQQ-----EEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 216 IVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQE 275
+ LRE+ +R+ E E L+ E Q + E+R + + + E+Q+
Sbjct: 1093 L--LREEPEK-RRRQERERQCREEEELQ-QEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 276 LLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKED 335
E+Q K R L + E E+E + + L++ E+ + +R+ + +E+
Sbjct: 1149 E-EEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLREEQEKRRQERERQ----YREE 1202
Query: 336 MEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQK 395
E + ++RY + S + EN + + + + E + + E +L +++
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 396 LQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQRE 455
QQ ++ L E + ++ + +RH EE++ E Q E K ++ + +++
Sbjct: 1263 SQQDLQ--HLLGEQQERDREQERRRWQQRDRHFPEEEQLER-EEQKEAKRRDRKSQEEKQ 1319
Query: 456 KMNEE-HNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHD 514
+ EE KR DR E + LQ E + ++ E RK EE L
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQ----------EREEQPLRRQERDRKFREEELRH 1369
Query: 515 KE---RLAEEIEKLRSE 528
+E + EE ++LR +
Sbjct: 1370 QEQGRKFLEEEQRLRRQ 1386
Score = 69.3 bits (168), Expect = 2e-11
Identities = 115/529 (21%), Positives = 206/529 (38%), Gaps = 43/529 (8%)
Query: 44 RLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEF 103
R D L++ +E L L ++R + + +R+ R+ L Q+ E L G ++ E
Sbjct: 1021 RKKDELQQEEEQL-LREEREKRRLQERERQYRE-EEELQQEEEQLLGEERETRRRQELER 1078
Query: 104 A-ALTKELNACREQLLEKEEEISELKAERNNTRL---LLEHLECLVSRHERSLRMTVVKR 159
+EL EQLL +E E + R L + E L+ R ++R
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 160 QAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVAL 219
Q + V E E L + + L+ + RE + E L EE QE
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198
Query: 220 REQNVHIQRKMASSEGSTESEHLE---GMEPGQ-------KVHEKRLSNGSIDSTDETS- 268
+ +QR+ E + + EP + KV+ K N +++
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258
Query: 269 ----QIVELQELL-EKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQ 323
+LQ LL E+Q + Q + R E EQ +K+ + + + + +
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 324 RDIREAMAQKEDMEE--RITTLEKRYLSAQRESTSIHDMNDKL--ENELANKEAILRQME 379
+ +RE +K +E R E++ L + E D+ E EL ++E + +E
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378
Query: 380 EKNR-------------QLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEER 426
E+ R + Q R + EQ+L+Q + E + +R + E++
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 427 HGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKE 486
E + LE + + + + ++ R+ E++ +E ++ +R E QL +E
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Query: 487 RMAALEEKNVLIQESETFRKNLEESLHDKER----LAEEIEKLRSELDQ 531
R E+ + QE E E+ LH ++R L EE + R E Q
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547
Score = 62.0 bits (149), Expect = 3e-09
Identities = 90/434 (20%), Positives = 182/434 (41%), Gaps = 46/434 (10%)
Query: 279 KQNYEMAQMKERLAALSSRVGEVE-QEAETARKDLIKTEEMNTKY--------QRDIREA 329
+Q + + + R L G+ Q+ + ++L + EE + K QR E
Sbjct: 114 RQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEEL 173
Query: 330 MAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAIL----RQMEEKNRQL 385
Q+++ +ER E+R Q +S H+ + + E + +L + EEK +Q
Sbjct: 174 WRQRQEWQERE---ERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQR 230
Query: 386 QERLE-LAEQKLQQTMRKAETL-----PEVEAELAQRIAALTKAEERHGNIEERMRHLEG 439
+ER + + +++ ++ RK ET+ +++ E QR L + EE+ +E + E
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 440 QLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQ 499
Q EE+ Q+ R Q+ + +E +R R E E+ + ++++ +E+ +
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE----R 346
Query: 500 ESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTH-LDTSAELRYS 558
+ R+ EE +++ E+ E+ R + QL+ E + R L +LR
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQ--QLRREQQLRREQQLRREQQLRREQQLR-- 402
Query: 559 VGSLVDSQSDYRTTKVIRRPR--RGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFES 616
+ R + +RR + R +RR++ + + HE R +Q L E
Sbjct: 403 ------REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQR--LKREQEER 454
Query: 617 DTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQE-----QLDAINKEIRLIQEEK 671
+ ++ +R L + + + L+E Q + +++R QEE+
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEER 514
Query: 672 ESTELRAEEIENRV 685
L+ +E E R+
Sbjct: 515 REQRLKRQEEEERL 528
Score = 56.2 bits (134), Expect = 2e-07
Identities = 82/357 (22%), Positives = 146/357 (40%), Gaps = 36/357 (10%)
Query: 115 EQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVL 174
E+ L +E E +L + + + LE E V R E+ + ++Q + G +
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFRLE--EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQ-- 1615
Query: 175 KALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSE 234
+ + E + L E+ ++L LEEE QE REQ + R E
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQE----REQQLRHDRDRKFRE 1671
Query: 235 GSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAAL 294
E + L+ E Q ++R + Q E + L E+Q +++ +
Sbjct: 1672 ---EEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREE 1728
Query: 295 SSRVGEVEQEA----ETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSA 350
E EQE E RK L EE + +R+ ++ Q+ D + R E+ L
Sbjct: 1729 EQLRQETEQEQLRRQERYRKIL---EEEQLRPEREEQQLRRQERDRKFR----EEEQLRQ 1781
Query: 351 QRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQER---LELAEQKLQQTMRKAETLP 407
+RE + + + +E + ++ EE+ + Q+R E++LQ L
Sbjct: 1782 EREEQQLRSQES--DRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ--------LE 1831
Query: 408 EVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKR 464
E E L Q +AEE+ +E+ R E +L ++ ++ +R + K+ EEH +R
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFAT-QEKSRREEQELWQEEEQKRRQERERKLREEHIRR 1887
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.347
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,646,694
Number of Sequences: 37866
Number of extensions: 2120394
Number of successful extensions: 24561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 451
Number of HSP's successfully gapped in prelim test: 1285
Number of HSP's that attempted gapping in prelim test: 9836
Number of HSP's gapped (non-prelim): 6910
length of query: 1257
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1143
effective length of database: 13,930,794
effective search space: 15922897542
effective search space used: 15922897542
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.