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Search of human proteins with 28827813
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28827813 NLR family, pyrin domain containing 14 [Homo
sapiens]
(1093 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 2244 0.0
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 715 0.0
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 709 0.0
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 677 0.0
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 672 0.0
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 636 0.0
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 624 e-178
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 624 e-178
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 620 e-177
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 586 e-167
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 576 e-164
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 573 e-163
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 570 e-162
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 560 e-159
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 547 e-155
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 531 e-150
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 515 e-145
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 427 e-119
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 427 e-119
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 427 e-119
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 423 e-118
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 423 e-118
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 329 1e-89
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 251 3e-66
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 234 4e-61
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 234 4e-61
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 234 4e-61
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 234 4e-61
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 234 4e-61
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 234 4e-61
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 2244 bits (5814), Expect = 0.0
Identities = 1093/1093 (100%), Positives = 1093/1093 (100%)
Query: 1 MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLAN 60
MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLAN
Sbjct: 1 MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLAN 60
Query: 61 LMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVL 120
LMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVL
Sbjct: 61 LMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVL 120
Query: 121 GDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVV 180
GDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVV
Sbjct: 121 GDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVV 180
Query: 181 LQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPST 240
LQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPST
Sbjct: 181 LQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPST 240
Query: 241 EGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPE 300
EGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPE
Sbjct: 241 EGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPE 300
Query: 301 ASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNE 360
ASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNE
Sbjct: 301 ASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNE 360
Query: 361 MLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPN 420
MLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPN
Sbjct: 361 MLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPN 420
Query: 421 QAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTH 480
QAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTH
Sbjct: 421 QAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTH 480
Query: 481 LHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDR 540
LHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDR
Sbjct: 481 LHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDR 540
Query: 541 VKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMR 600
VKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMR
Sbjct: 541 VKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMR 600
Query: 601 CFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITH 660
CFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITH
Sbjct: 601 CFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITH 660
Query: 661 CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQD 720
CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQD
Sbjct: 661 CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQD 720
Query: 721 ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISN 780
ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISN
Sbjct: 721 ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISN 780
Query: 781 ALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALI 840
ALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALI
Sbjct: 781 ALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALI 840
Query: 841 SNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNK 900
SNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNK
Sbjct: 841 SNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNK 900
Query: 901 SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLR 960
SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLR
Sbjct: 901 SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLR 960
Query: 961 SLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMN 1020
SLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMN
Sbjct: 961 SLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMN 1020
Query: 1021 LTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
LTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN
Sbjct: 1021 LTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
Query: 1081 YHNEEDVSWWWCF 1093
YHNEEDVSWWWCF
Sbjct: 1081 YHNEEDVSWWWCF 1093
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 715 bits (1846), Expect = 0.0
Identities = 405/1076 (37%), Positives = 613/1076 (56%), Gaps = 91/1076 (8%)
Query: 6 SSSFFPDFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKK 64
++SFF DFGL+ YLEEL KEE FK LK+ T++ E PW EVKKA RE+LANL+ K
Sbjct: 2 AASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIK 61
Query: 65 YYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGT 124
+Y ++AW+++L+IF KM+ KDLC + E + G T+
Sbjct: 62 HYEEQQAWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKT---------- 98
Query: 125 EYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGA 184
Y+ K+KF W KS+ F + +++ L+ LF + G QP+ V++QG
Sbjct: 99 -YQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLF-APKEAGKQPRTVIIQGP 156
Query: 185 AGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPI 244
G+GKTTL+ K M+ W++ +++ RF Y FY RE+ +L S A LIS++WP PI
Sbjct: 157 QGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPI 216
Query: 245 EEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLL 304
EI+ QP LLF+IDSF+EL EP+ LC D ++ PV L+SSLLRK MLPEASLL
Sbjct: 217 TEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLL 276
Query: 305 VTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFS 364
+ + K L+ + + G +E R Y FF+D + AM+ F+ ++ +E LFS
Sbjct: 277 IAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFS 336
Query: 365 MCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQL 424
+CQ+PL+CW CT LKQ+M+KG D+ LTCQ+TT++++ ++ +LFTP P+ Q QL
Sbjct: 337 ICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQL 396
Query: 425 RRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQ 484
+ LC +AA+G+WT T+ F ++LRR G+ +D+ + + + I+ K E E+ YVF H+ +Q
Sbjct: 397 KALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQ 456
Query: 485 EFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQL 544
EF AA+FY+LK + +P+ + ++L + + H + CFL GLLN+ ++L
Sbjct: 457 EFCAALFYLLKSHLDHPHPAVRCVQELL-VANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
Query: 545 ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPK 604
+ F ++S +IK ++ QC++ LG Q+ L +F+CL+E QD AF+ QA+ +
Sbjct: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
Query: 605 VAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQD 664
+I + + L+VS++CLK+C LR + SV VF+ K ++T D I CW
Sbjct: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK----KEDEHSSTSDYSLI--CW-- 627
Query: 665 LCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTS 724
HH C ++TS
Sbjct: 628 -----------------------------HHI---------------------CSVLTTS 637
Query: 725 LIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIR 784
+L L ++ S + ++ + C L+HP C+LQ L + + + + L + L
Sbjct: 638 ----GHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFEVLFY 692
Query: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
L +L+ + L D ++ LC+AL +P ++ L+L +C L+ CE L+ L +NK+
Sbjct: 693 QPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKK 752
Query: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
LT+L ++ N L D GV L+ +AL L L+L CH + EY+S LL NKS+ +
Sbjct: 753 LTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRY 811
Query: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
LDL +N L+D G+K LC+ +HP C L L L+ C +T A C DLAS +++N NL+ L +
Sbjct: 812 LDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQI 871
Query: 965 GNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQN 1024
G N++ D GV++LC AL + +C ++ LGLE CGLTS CC+DL+S L C+K L ++NLT N
Sbjct: 872 GCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLN 931
Query: 1025 TLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
TL + G+V L + L+ P+C LQVLGL K FDEE Q LL A NP+L I DC+
Sbjct: 932 TLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCD 987
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 709 bits (1830), Expect = 0.0
Identities = 426/1155 (36%), Positives = 632/1155 (54%), Gaps = 76/1155 (6%)
Query: 3 DSSSSSFFPDFGLLLYLEELNKEELNTFK-LFLKETMEPEHGLTPWNEVKKARREDLANL 61
+ S F +GL L EL+KEE TFK L K++ E P E++ A E LA L
Sbjct: 53 EGDKSLTFSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALL 112
Query: 62 MKKYYPGEKAWSVSLKIFGKMNLKDLCERA----------------------KEEINWSA 99
+ +YY AW+ S+ IF MNL+ L E+A KE++ +
Sbjct: 113 LHEYYGASLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGIS 172
Query: 100 QTIGPDDAKAGETQE-------DQEAVL-----------------------------GDG 123
Q + D A A ET+E +QE GD
Sbjct: 173 QAVQQDSATAAETKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDT 232
Query: 124 TEYRNRIKEKFCITWD-KKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQ 182
+Y++ + KF D ++S D+ + + L FD D + G +P+ VVL
Sbjct: 233 WDYKSHVMTKFAEEEDVRRSFENTAADW------PEMQTLAGAFDSD-RWGFRPRTVVLH 285
Query: 183 GAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEG 242
G +G+GK+ L R+ +L WA+G LYQ F YVF+L RE+ + KE S + IS++WP ++
Sbjct: 286 GKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQA 345
Query: 243 PIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEAS 302
P+ EIM +P LLFIID FD+L + LC+DW ++ P L+ SLLRKV+LPE+
Sbjct: 346 PVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRKVLLPESF 404
Query: 303 LLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEML 362
L+VT R +++LK + + Y+ + G+S + R + + + + ++ +N L
Sbjct: 405 LIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNREL 464
Query: 363 FSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTP--VDGGSPSLPN 420
CQVP V C L+ Q G V QT T L ++ TP V +L
Sbjct: 465 LDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEE 524
Query: 421 QAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTH 480
+ L+R C++A +G+W VF ++L GL +S++ + NI+ D+ E Y F H
Sbjct: 525 RVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFH 584
Query: 481 LHVQEFFAAMFYMLKGSWEAGNPSCQPF--EDLKSLLQSTSYKDPHLTQMKCFLFGLLNE 538
L +Q+F AA++Y+L+G E C + + +S+ + H MK FLFGL++E
Sbjct: 585 LSLQDFCAALYYVLEG-LEIEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSE 643
Query: 539 DRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQA 598
D + LE C + L +K KLL + +LG + + L+ FHCL+ETQDK F+ A
Sbjct: 644 DVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKEFVRLA 703
Query: 599 MRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLP-TNTWDGDR 657
+ F +V + I + + L+ SSFCL+HC LR IR+ V +F + + P W D+
Sbjct: 704 LNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPLWMRDK 763
Query: 658 --ITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFP 715
I W+D CS+L T+ HLR+LDL S L + AM L +LRHP CK+Q L+ +
Sbjct: 764 TLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRNAQIT 823
Query: 716 DGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCC 775
G Q + ++ N+NL L+L G+ + + V+ CEALKHP+C L++LRL+ C LT C
Sbjct: 824 PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACY 883
Query: 776 LNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYL 835
L IS L S SL L+L+ N + D GV L +ALR +C L++L LE CG+T GC+ L
Sbjct: 884 LKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSL 943
Query: 836 SLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTS 895
+ AL+SN+ LTHLCL++N LG+ GV L+ +++ C+L+ L+L +CH + +L+ +
Sbjct: 944 ASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALA 1003
Query: 896 LLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILN 955
L+ N LTHL L N ++DNGVKLLC+V R PSC+LQDLEL+ C LT ACC L+ VI
Sbjct: 1004 LMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISR 1063
Query: 956 NPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKR 1015
+ +L+SLDL +N L D GV LC+ L+ N + RLGL+ CGLTS CC+ LS AL CN+
Sbjct: 1064 SRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRH 1123
Query: 1016 LIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
L +NL QN +G++KL P LQ++GL K + + +KLLE V + P ++I
Sbjct: 1124 LTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLKPRVVI 1183
Query: 1076 KPDCNYHNEEDVSWW 1090
+ +E+D WW
Sbjct: 1184 DGSWHSFDEDDRYWW 1198
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 677 bits (1747), Expect = 0.0
Identities = 377/993 (37%), Positives = 577/993 (58%), Gaps = 42/993 (4%)
Query: 6 SSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEP-EHGLTPWNEVKKARREDLANLMKK 64
+ SFF DFGLL YL+EL KEE FK LK+ +E E PW E+KKA +ED+A L+ K
Sbjct: 2 AESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLDK 61
Query: 65 YYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGT 124
+YPG++AW V+L +F ++N KDL +A+EE+ + P
Sbjct: 62 HYPGKQAWEVTLNLFLQINRKDLWTKAQEEMR---NKLNP-------------------- 98
Query: 125 EYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGA 184
YR +KE F + W+K++ PE F+ + + K L + A+ VVL+G
Sbjct: 99 -YRKHMKETFQLIWEKETCLHVPEHFYKETMKNEYKELNDAYTA----AARRHTVVLEGP 153
Query: 185 AGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPI 244
G+GKTTL+RK MLDWAEG+L++ RF +VF+LN E+N + E S +L+S+DWP + I
Sbjct: 154 DGIGKTTLLRKVMLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKI 213
Query: 245 EEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLL 304
E+I QP +LFI+D F++L F + + L +DW Q P+ ++SSLL+K MLPE+SLL
Sbjct: 214 EDIFSQPERILFIMDGFEQLKFNLQL-KADLSDDWRQRQPMPIILSSLLQKKMLPESSLL 272
Query: 305 VTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFS 364
+ ++ +L++ ++LLG SE ++ Y FF +K A+KVF+ ++ N LF
Sbjct: 273 IALGKLAMQKHYFMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFI 332
Query: 365 MCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQL 424
+C P CW CTC+KQ++E+G D+ + Q TT L+ +++++F P N+A+L
Sbjct: 333 LCHNPFTCWLVCTCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARL 392
Query: 425 RRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQ 484
+ LC +AA+GIWT T+VF +LRR GL++S+ ++ ++Q+ + C+ F HL +Q
Sbjct: 393 KSLCALAAEGIWTYTFVFSHGDLRRNGLSESEGVMWVGMRLLQRRGD---CFAFMHLCIQ 449
Query: 485 EFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQL 544
EF AAMFY+LK + NP+ L + S LTQ+ F+FG+ E+ V L
Sbjct: 450 EFCAAMFYLLKRPKDDPNPAIGSITQL--VRASVVQPQTLLTQVGIFMFGISTEEIVSML 507
Query: 545 ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPK 604
E +F +S +K ++ QC+E L + + F ELF L+ETQ+K F+++ M F +
Sbjct: 508 ETSFGFPLSKDLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEE 567
Query: 605 VAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQD 664
V I I HL+++SFCLKHC+ L T+R+ V +F S D + W++
Sbjct: 568 VFIYIGNIEHLVIASFCLKHCQHLTTLRMCVENIFPDDSGCIS------DYNEKLVYWRE 621
Query: 665 LCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTS 724
LCS+ TN++ + LD+ +++LD ++ IL L P CKL+KL+ + F ++ +
Sbjct: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHD-SELFKA 680
Query: 725 LIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIR 784
++HN +L L L G+ + + ++ LCE LKHP CK++ L L C+++ C +I++ L
Sbjct: 681 VLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLAC 740
Query: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
+ L L+L N L D+G+ LLCEAL+H C LERL L C LT C+ +S L+ +K
Sbjct: 741 NSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKS 800
Query: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
L+ L L N L D GV + AL+H C+++ L L C TS S + ++ L+ N L
Sbjct: 801 LSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKT 860
Query: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
L LG N + D GV+ LC +HP C L+ L L C +T ACC D+A+ ++ LRSL+L
Sbjct: 861 LKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNL 920
Query: 965 GNNDLQDDGVKILCDALRYPNCNIQRLGLEYCG 997
L D V +LC+AL +P+C +Q LGL G
Sbjct: 921 DWIALDADAVVVLCEALSHPDCALQMLGLHKSG 953
Score = 147 bits (372), Expect = 4e-35
Identities = 91/254 (35%), Positives = 135/254 (53%), Gaps = 5/254 (1%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
+D+ SVL N L+ L L + L M +L L+H +C L++L+L + C I
Sbjct: 732 EDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSI 791
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
S L+ +K+L LDL + + DNGV SLC ALKHP C ++ L L C LT C +I+
Sbjct: 792 SEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAV 851
Query: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
LI + L L L N + D GV+ LC AL+HP C LE L L++C +T A C+ ++ ALI+
Sbjct: 852 LICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIA 911
Query: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
K L L L L V ++ +AL H C L+ L L + F + + L + +
Sbjct: 912 CKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSV---EEK 968
Query: 902 LTHLDLGSN-WLQD 914
+ HL + W+ +
Sbjct: 969 IPHLTISHGPWIDE 982
Score = 36.2 bits (82), Expect = 0.17
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 2/76 (2%)
Query: 661 CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQD 720
C D+ + L + LR L+L LD A+ +L L HP+C LQ L L F + Q
Sbjct: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
Query: 721 ISTSLIHNKNLMHLDL 736
I S+ + + HL +
Sbjct: 961 ILMSV--EEKIPHLTI 974
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 672 bits (1733), Expect = 0.0
Identities = 411/1101 (37%), Positives = 594/1101 (53%), Gaps = 94/1101 (8%)
Query: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSV 74
L YLEEL EL FKL+L E G PW ++KA ++A L+ ++ E+AW +
Sbjct: 13 LSTYLEELEAVELKKFKLYLGTATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWRL 72
Query: 75 SLKIFGKMNLKDLCERA-KEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTE----YRNR 129
+L F ++N KDL ER +E++ GP T + +++ + YR+
Sbjct: 73 ALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDY 132
Query: 130 IKEKFCITWDKKSLAGKPEDFHHGIA------------EKDRKLL--------------- 162
++ KF + D+ + G+ + H + ++LL
Sbjct: 133 VRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQAS 192
Query: 163 ----EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNG 218
E LF+ D + P+ VV+QGAAG+GK+ L K MLDWA+G L+Q RF Y+FY+N
Sbjct: 193 PIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINC 252
Query: 219 REINQ-LKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCE 277
RE+NQ E S LI WP P++E++ P LLFIID FDEL +F +P+ C
Sbjct: 253 REMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCL 312
Query: 278 DWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREE 337
W ++ P L++SL+RK +LPE SLL+TTR T ++L +LL++ +VE+LG SE R+E
Sbjct: 313 CWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKE 372
Query: 338 YIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTT 397
Y Y++F + A +VF+ ++ NE LF+MC VPLVCW CTCL+QQ+E GG + T +TTT
Sbjct: 373 YFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTT 432
Query: 398 ALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDV 457
A++ Y+ SL P G +P L R LC +AA G+W +F ++LR+ GL DV
Sbjct: 433 AVYMLYLLSLMQPKPG-APRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
Query: 458 SSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQS 517
S+F++ NI QKD E Y F HL QEFFAAM+Y+L + G P +D+ LL
Sbjct: 492 SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYIL----DEGEGGAGPDQDVTRLLTE 547
Query: 518 TSYKD-PHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQ 576
++ + L FLFGLLNE+ LE++ K+S IK LLQ ++ SD S Q
Sbjct: 548 YAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQ 607
Query: 577 LGFLELFHCLYETQDKAFISQAMRCFPKVAI-NICEKIHLLVSSFCLKHCRCLRTIRLSV 635
G LE F CLYE Q++ FI QA+ F + + NI K+ +VSSFCLK CR + + L
Sbjct: 608 QGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYG 667
Query: 636 TVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVL-HTNEHLRELDLYHSNLDKSAMNILH 694
T + DG+ C ++L E LD Y +L
Sbjct: 668 A-------------TYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHL--------- 705
Query: 695 HELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALK 754
+ +L N NL+ L L + +G GVK LC+ L+
Sbjct: 706 ---------------------------AAALCTNPNLIELSLYRNALGSRGVKLLCQGLR 738
Query: 755 HPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPK 814
HP CKLQ LRL+ C ++ C ++S ALI +++L ++LS N + G+ LLCE LRHP+
Sbjct: 739 HPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQ 798
Query: 815 CYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTL 874
C L+ + L C L C+ ++ L +N L L L N L D G++L+ L+H C L
Sbjct: 799 CRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRL 858
Query: 875 KSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDL 934
++L L+ C T+ + + L+++L N+SL LDL N L D GV LLC+ RHP+C LQ L
Sbjct: 859 RTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTL 918
Query: 935 ELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLE 994
L C L +A C L+ V+ N NLR LDL NDL D G+ +L + L++P C +Q+L L+
Sbjct: 919 RLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLD 978
Query: 995 YCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEA 1054
CGLT+ C++L L N+ L + LT N LG G+ L K L P CKL+VL L
Sbjct: 979 SCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMD 1038
Query: 1055 FDEEAQKLLEAVGVSNPHLII 1075
++ L A+ V+ P+L I
Sbjct: 1039 LNKMTHSRLAALRVTKPYLDI 1059
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 636 bits (1641), Expect = 0.0
Identities = 395/1038 (38%), Positives = 569/1038 (54%), Gaps = 69/1038 (6%)
Query: 14 GLLLYLEELNKEELNTFKLFLKETM--------EPEHGLTPWNEVKKARREDLANLMKKY 65
GLL YL L++ +L FKL L+ + PW ++ A +L+ L+ ++
Sbjct: 16 GLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEH 75
Query: 66 YPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTI----------------------- 102
+P +AW V L IF MNL LCE+ + E+ + QT
Sbjct: 76 FPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
Query: 103 ---GPDDAKAGETQEDQEAVLGDGTE------------------YRNRIKEKFCITWDKK 141
P+ + E +E+ V G + YR +K + TWD
Sbjct: 136 GCQDPNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNI 195
Query: 142 SLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWA 201
S K + ++ + + L+ L D + +T AQ Q +VL G AGVGKTTL +AML WA
Sbjct: 196 SWP-KDHVYIRNTSKDEHEELQRLLDPN-RTRAQAQTIVLVGRAGVGKTTLAMQAMLHWA 253
Query: 202 EGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSF 261
G L+QQRF YVFYL+ +I +KE +FA+LIS DWP + PIEE M QP LLFIID F
Sbjct: 254 NGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGF 313
Query: 262 DELNFAFEEPEF----ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQ 317
+E+ + E + C DW QE PV+ ++ SLL+K ++P A+LL+T + + LK
Sbjct: 314 EEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKA 373
Query: 318 LLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACT 377
L N +V++ G + D Y + F+D K+ L+ NE LF C P+VCW C+
Sbjct: 374 SLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCS 433
Query: 378 CLKQQMEKGGDVTLTCQTTTALFTCYISSLFTP--VDGGSPSLPNQAQLRRLCQVAAKGI 435
CLKQ + D+ QTTT+L+ + S+LF+ VD S P Q R LC +A +G+
Sbjct: 434 CLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQ--WRALCSLAIEGL 491
Query: 436 WTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLK 495
W+M + F +E+ GL + S + NI+QK + C FTHL QEFFAAM ++L+
Sbjct: 492 WSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVLE 551
Query: 496 GSWEAGNPSCQPFEDLKSLLQSTSY-KDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
E S +P +++K LLQ K+ + T + F FGLLN++ ++LE T +CK+S
Sbjct: 552 EPREFPPHSTKP-QEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISP 610
Query: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
++ +LL+ E LG ++ + Q L LFHCL+E+Q++ F + + +V +NI E
Sbjct: 611 RVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEE 670
Query: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674
L SSFCLKHC+ L +RLSV+ ++ L+ L T+ +D H W +CS L TNE+
Sbjct: 671 LQASSFCLKHCKRLNKLRLSVSSHILERDLEI-LETSKFDSR--MHAWNSICSTLVTNEN 727
Query: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734
L ELDL +S L S++ L L++P CK+QKL K +T QD+ +L N L HL
Sbjct: 728 LHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHL 787
Query: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
+ + +G V + +AL+H C L+ L LE CNL+ C +++ L Q + L L
Sbjct: 788 NFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLG 846
Query: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854
N L DDG++LLC AL HPKC LERL L C L C++LS AL+ N+ LTHL L+ N
Sbjct: 847 FNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNS 906
Query: 855 LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914
L D GVK + +AL L+SL L C FT L+ +L HN ++ LDLG N LQD
Sbjct: 907 LRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQD 966
Query: 915 NGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGV 974
+GVKLLC+ + P L L L C LT ACC L SV+ ++ +L +L+L N+L DGV
Sbjct: 967 DGVKLLCEALK-PHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGV 1025
Query: 975 KILCDALRYPNCNIQRLG 992
K+LC AL+ C +Q+LG
Sbjct: 1026 KMLCKALKKSTCRLQKLG 1043
Score = 128 bits (321), Expect = 3e-29
Identities = 103/322 (31%), Positives = 163/322 (50%), Gaps = 29/322 (9%)
Query: 759 KLQTLRLESCNLTVFCCLNISNALIRSQSLI--FLNLSTNNLLDDGVQLLCEALRHPKCY 816
K ++ L+ L +F CL+ S ++ ++ + N L D+ +Q L+H K
Sbjct: 625 KAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSFCLKHCK-R 683
Query: 817 LERLSLE-SCGLTEAGCEYLSLA---------------LISNKRLTHLCLADNVLGDGGV 860
L +L L S + E E L + L++N+ L L L+++ L V
Sbjct: 684 LNKLRLSVSSHILERDLEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSV 743
Query: 861 KLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL----HNKSLTHLDLGSNWLQDNG 916
K + AL++ +C ++ L + S++ E++ L+ N LTHL+ SN L
Sbjct: 744 KGLCLALKNPRCKVQKLTCK-----SVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMT- 797
Query: 917 VKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKI 976
V L+ RH +CNL+ L L C L+ A C DLA + + ++ L LG N LQDDG+K+
Sbjct: 798 VPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKL 857
Query: 977 LCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYK 1036
LC AL +P C ++RL L +C L + C+ LS AL+ N+ L +NL++N+L EG+ L +
Sbjct: 858 LCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCE 917
Query: 1037 VLKSPKCKLQVLGLCKEAFDEE 1058
L P LQ L L +F E
Sbjct: 918 ALGRPDGNLQSLNLSGCSFTRE 939
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 624 bits (1609), Expect = e-178
Identities = 385/1039 (37%), Positives = 572/1039 (55%), Gaps = 103/1039 (9%)
Query: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPGEKAW 72
L YLE+L +L FK+ L E P+ G P + +KA DLA LM + EKAW
Sbjct: 10 LARYLEDLEDVDLKKFKMHL-EDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 73 SVSLKIFGKMNLKDLCERAK-EEINWSAQTIGPDDAKAGET----QED--QEAVLG---- 121
++++ IF +N +DL E+AK +E W G D+A+ QED +E +G
Sbjct: 69 AMAVWIFAAINRRDLYEKAKRDEPKW-----GSDNARVSNPTVICQEDSIEEEWMGLLEY 123
Query: 122 ------------DGTEYRNRIKEKFCITWDKKSLAGKPEDF------------HHGIAEK 157
+YR ++ +F D+ + G+ H E+
Sbjct: 124 LSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQER 183
Query: 158 DRKLL-----------------EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDW 200
+++LL E LFD D + VV QGAAG+GKT L RK MLDW
Sbjct: 184 EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDW 243
Query: 201 AEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDS 260
A G+LYQ RF Y+FY++ RE++ + +RS LI P PI +I+ +PS +LF++D
Sbjct: 244 ASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDG 303
Query: 261 FDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLK 320
FDEL AF+E LC DW + L+SSL+RK +LPEASLL+TTR ++L+ LL
Sbjct: 304 FDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLD 363
Query: 321 NHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK 380
+ +VE+LG SE R+EY +++F D+ A FS ++ NE+LF+MC +PLVCW CT LK
Sbjct: 364 HPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLK 423
Query: 381 QQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTY 440
QQME G + T +TTTA++ ++SSL P GGS A L LC +AA GIW
Sbjct: 424 QQMESGKSLAQTSKTTTAVYVFFLSSLLQP-RGGSQEHGLCAHLWGLCSLAADGIWNQKI 482
Query: 441 VFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEA 500
+F +LR GL ++DVS+F+ N+ QK+ + E Y F H+ QEFFAAM+Y+L+ E
Sbjct: 483 LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG 542
Query: 501 -----GNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
G+ P D+ LL++ ++ +L + FLFGL+N++R LE+ +CK+S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
+I+ +LL+ +EV + Q LELF+CLYE Q++ F+ +AM FPK+ IN+ ++
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674
+VSSFC+++C + ++ L ++P + ++
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL---------HNMPKEEEEEEK----------------E 697
Query: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734
R LD+ L S+ H L + + L F C+ + + L +++L L
Sbjct: 698 GRHLDMVQCVLPSSSHAACSHGLVNSH-----LTSSF------CRGLFSVLSTSQSLTEL 746
Query: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
DL + +GD G++ LCE L+HP C ++ L L C L+ CC +IS L +Q L+ L+LS
Sbjct: 747 DLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLS 806
Query: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854
N L D G++LLC L+H C L++L L SC LT A C+ L+ L ++ LT L + +N
Sbjct: 807 DNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENA 866
Query: 855 LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914
LGD GV ++ + ++ QC L+ L L TS+ LS+ L N++LTHL L N L D
Sbjct: 867 LGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGD 926
Query: 915 NGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGV 974
G+KLLC+ HP C LQ LEL C LT+ CC DL++++ ++ +LR L LGNNDL D GV
Sbjct: 927 KGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGV 986
Query: 975 KILCDALRYPNCNIQRLGL 993
+ C+ L+ +C +Q LGL
Sbjct: 987 MMFCEVLKQQSCLLQNLGL 1005
Score = 240 bits (613), Expect = 5e-63
Identities = 143/366 (39%), Positives = 205/366 (56%), Gaps = 21/366 (5%)
Query: 719 QDISTSLIHN---------KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCN 769
+ +S +HN K HLD+ V+ + + H C + L + +
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDM---------VQCVLPSSSHAAC---SHGLVNSH 724
Query: 770 LTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
LT C + + L SQSL L+LS N+L D G+++LCE L+HP C + RL L CGL+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 830 AGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSS 889
C +SL L SN++L L L+DN LGD G++L+ L+H C LK L L C TS
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
+ L++ L + SLT L +G N L D+GV +LC+ ++P CNLQ L L+ LT+ CC L
Sbjct: 845 QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
+SV+ N NL L L N L D G+K+LC+ L +P+C +Q L L+ C LTS CC DLS+
Sbjct: 905 SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
Query: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069
L ++ L K++L N LG G++ +VLK C LQ LGL + F+ E + LE +
Sbjct: 965 LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEE 1024
Query: 1070 NPHLII 1075
P L +
Sbjct: 1025 KPELTV 1030
Score = 147 bits (370), Expect = 7e-35
Identities = 91/244 (37%), Positives = 130/244 (53%), Gaps = 1/244 (0%)
Query: 661 CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGC-Q 719
C D+ VL +N+ L ELDL + L + +L L+H C L+KL L C Q
Sbjct: 786 CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 845
Query: 720 DISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNIS 779
D+++ L + +L L + + +GD+GV LCE K+P+C LQ L L + LT CC +S
Sbjct: 846 DLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALS 905
Query: 780 NALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839
+ L +Q+L L L N L D G++LLCE L HP C L+ L L++C LT C LS L
Sbjct: 906 SVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLL 965
Query: 840 ISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHN 899
S++ L L L +N LGD GV + + L+ C L++L L +F + L T
Sbjct: 966 TSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEK 1025
Query: 900 KSLT 903
LT
Sbjct: 1026 PELT 1029
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 624 bits (1609), Expect = e-178
Identities = 385/1039 (37%), Positives = 572/1039 (55%), Gaps = 103/1039 (9%)
Query: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPGEKAW 72
L YLE+L +L FK+ L E P+ G P + +KA DLA LM + EKAW
Sbjct: 10 LARYLEDLEDVDLKKFKMHL-EDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 73 SVSLKIFGKMNLKDLCERAK-EEINWSAQTIGPDDAKAGET----QED--QEAVLG---- 121
++++ IF +N +DL E+AK +E W G D+A+ QED +E +G
Sbjct: 69 AMAVWIFAAINRRDLYEKAKRDEPKW-----GSDNARVSNPTVICQEDSIEEEWMGLLEY 123
Query: 122 ------------DGTEYRNRIKEKFCITWDKKSLAGKPEDF------------HHGIAEK 157
+YR ++ +F D+ + G+ H E+
Sbjct: 124 LSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQER 183
Query: 158 DRKLL-----------------EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDW 200
+++LL E LFD D + VV QGAAG+GKT L RK MLDW
Sbjct: 184 EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDW 243
Query: 201 AEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDS 260
A G+LYQ RF Y+FY++ RE++ + +RS LI P PI +I+ +PS +LF++D
Sbjct: 244 ASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDG 303
Query: 261 FDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLK 320
FDEL AF+E LC DW + L+SSL+RK +LPEASLL+TTR ++L+ LL
Sbjct: 304 FDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLD 363
Query: 321 NHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK 380
+ +VE+LG SE R+EY +++F D+ A FS ++ NE+LF+MC +PLVCW CT LK
Sbjct: 364 HPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLK 423
Query: 381 QQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTY 440
QQME G + T +TTTA++ ++SSL P GGS A L LC +AA GIW
Sbjct: 424 QQMESGKSLAQTSKTTTAVYVFFLSSLLQP-RGGSQEHGLCAHLWGLCSLAADGIWNQKI 482
Query: 441 VFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEA 500
+F +LR GL ++DVS+F+ N+ QK+ + E Y F H+ QEFFAAM+Y+L+ E
Sbjct: 483 LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG 542
Query: 501 -----GNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
G+ P D+ LL++ ++ +L + FLFGL+N++R LE+ +CK+S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
+I+ +LL+ +EV + Q LELF+CLYE Q++ F+ +AM FPK+ IN+ ++
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674
+VSSFC+++C + ++ L ++P + ++
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL---------HNMPKEEEEEEK----------------E 697
Query: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734
R LD+ L S+ H L + + L F C+ + + L +++L L
Sbjct: 698 GRHLDMVQCVLPSSSHAACSHGLVNSH-----LTSSF------CRGLFSVLSTSQSLTEL 746
Query: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
DL + +GD G++ LCE L+HP C ++ L L C L+ CC +IS L +Q L+ L+LS
Sbjct: 747 DLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLS 806
Query: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854
N L D G++LLC L+H C L++L L SC LT A C+ L+ L ++ LT L + +N
Sbjct: 807 DNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENA 866
Query: 855 LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914
LGD GV ++ + ++ QC L+ L L TS+ LS+ L N++LTHL L N L D
Sbjct: 867 LGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGD 926
Query: 915 NGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGV 974
G+KLLC+ HP C LQ LEL C LT+ CC DL++++ ++ +LR L LGNNDL D GV
Sbjct: 927 KGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGV 986
Query: 975 KILCDALRYPNCNIQRLGL 993
+ C+ L+ +C +Q LGL
Sbjct: 987 MMFCEVLKQQSCLLQNLGL 1005
Score = 240 bits (613), Expect = 5e-63
Identities = 143/366 (39%), Positives = 205/366 (56%), Gaps = 21/366 (5%)
Query: 719 QDISTSLIHN---------KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCN 769
+ +S +HN K HLD+ V+ + + H C + L + +
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDM---------VQCVLPSSSHAAC---SHGLVNSH 724
Query: 770 LTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
LT C + + L SQSL L+LS N+L D G+++LCE L+HP C + RL L CGL+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 830 AGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSS 889
C +SL L SN++L L L+DN LGD G++L+ L+H C LK L L C TS
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
+ L++ L + SLT L +G N L D+GV +LC+ ++P CNLQ L L+ LT+ CC L
Sbjct: 845 QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
+SV+ N NL L L N L D G+K+LC+ L +P+C +Q L L+ C LTS CC DLS+
Sbjct: 905 SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
Query: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069
L ++ L K++L N LG G++ +VLK C LQ LGL + F+ E + LE +
Sbjct: 965 LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEE 1024
Query: 1070 NPHLII 1075
P L +
Sbjct: 1025 KPELTV 1030
Score = 147 bits (370), Expect = 7e-35
Identities = 91/244 (37%), Positives = 130/244 (53%), Gaps = 1/244 (0%)
Query: 661 CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGC-Q 719
C D+ VL +N+ L ELDL + L + +L L+H C L+KL L C Q
Sbjct: 786 CCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQ 845
Query: 720 DISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNIS 779
D+++ L + +L L + + +GD+GV LCE K+P+C LQ L L + LT CC +S
Sbjct: 846 DLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALS 905
Query: 780 NALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839
+ L +Q+L L L N L D G++LLCE L HP C L+ L L++C LT C LS L
Sbjct: 906 SVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLL 965
Query: 840 ISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHN 899
S++ L L L +N LGD GV + + L+ C L++L L +F + L T
Sbjct: 966 TSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEK 1025
Query: 900 KSLT 903
LT
Sbjct: 1026 PELT 1029
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 620 bits (1600), Expect = e-177
Identities = 361/971 (37%), Positives = 540/971 (55%), Gaps = 10/971 (1%)
Query: 14 GLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWS 73
G++LY+ ++ EEL FK L + W++V+ A ++ +L+ + +PG +AW
Sbjct: 40 GVMLYMRNVSHEELQRFKQLLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWD 99
Query: 74 VSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQED-QEAVLGDGTEYRNRIKE 132
V+ IF MN +C + EIN T+ P+D GETQ + +E G Y++ + E
Sbjct: 100 VTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVME 159
Query: 133 KFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTL 192
KF WD + G DF + + + L L G QP+ V +QGA G+GKT L
Sbjct: 160 KFFPIWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTIL 219
Query: 193 VRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPS 252
+K M +WA Y + FY + +E+NQ ++SF++LI + WP ++ + +IM +P
Sbjct: 220 AKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPD 279
Query: 253 SLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTS 312
LL ++D F+EL + L EDW Q+ P S L+SSLL K MLPEA+LL+ R T+
Sbjct: 280 QLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSW 339
Query: 313 KRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVC 372
+ K LLK V L G + + +Y +F +V S N +LFSMC+VP+VC
Sbjct: 340 QTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVC 399
Query: 373 WAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAA 432
W C+ LKQQME+G ++T +C T++F YISSLF +QAQL LC +AA
Sbjct: 400 WMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAA 459
Query: 433 KGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFY 492
+W +V +E+L L Q+ V++F+ +I+++ A E+ YVFT + QEFFAA+FY
Sbjct: 460 DSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFY 519
Query: 493 MLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKM 552
+L N +++ L+ S +L+ M FLFG LNE +E++F CK+
Sbjct: 520 VLCFPQRLKNFHVLSHVNIQRLIASPRGSKSYLSHMGLFLFGFLNEACASAVEQSFQCKV 579
Query: 553 SLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEK 612
S K KLL+ + +L D G +LF+CL+E +++AF+SQA+ + KV + I
Sbjct: 580 SFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNN 639
Query: 613 IHLLVSSFCLKHCRCLRTIRLSVTVVFEK--KILKTSLP-TNTWDGDRITHCWQDLCSVL 669
+ VS+FCLK C+ L + L+VT+ F K+ +S P + + + + WQDLCSV
Sbjct: 640 KEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLCSVF 699
Query: 670 HTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNK 729
TN+ L L + +S L + L LRHP CKLQKLLL+ + QD+ L N+
Sbjct: 700 ATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLTGNQ 759
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
+L +L+++ ++ VK LC L+ P C+LQ LRLE C T ++ N L + L
Sbjct: 760 HLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLK 819
Query: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
L L N+L + G L A LERLS+E+C LT+ CE L+ L +K LTHL
Sbjct: 820 TLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQSKMLTHLS 873
Query: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
LA+N L D G K + +AL H +C L+ LVLR+C T + + ++L NK+L LDL
Sbjct: 874 LAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSF 933
Query: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
N L+D+GV LLC+ ++P C LQ LEL C+ T+ CC +AS++ N +LR LDL N +
Sbjct: 934 NSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAI 993
Query: 970 QDDGVKILCDA 980
G+ LC+A
Sbjct: 994 GVYGILTLCEA 1004
Score = 126 bits (316), Expect = 1e-28
Identities = 88/284 (30%), Positives = 133/284 (46%), Gaps = 52/284 (18%)
Query: 841 SNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNK 900
+N +L L + ++VLG +K ++ AL+H QC L+ L+LRR + T L+ + + L N+
Sbjct: 701 TNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGV-LTGNQ 759
Query: 901 SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCV-------------------- 940
L +L++ ++ VKLLC V R P C LQ L L C+
Sbjct: 760 HLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNGHLK 819
Query: 941 -------------------------------LTNACCLDLASVILNNPNLRSLDLGNNDL 969
LT C LAS + + L L L N L
Sbjct: 820 TLILRKNSLENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENAL 879
Query: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
+D+G K + +AL + C +QRL L C LT CCQD+ SAL NK L ++L+ N+L +
Sbjct: 880 KDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDD 939
Query: 1030 GIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
G++ L + LK+P C LQ+L L F + + ++ N HL
Sbjct: 940 GVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHL 983
Score = 97.1 bits (240), Expect = 8e-20
Identities = 59/154 (38%), Positives = 87/154 (56%), Gaps = 3/154 (1%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKF--ITFPDGCQD 720
+ L S L ++ L L L + L + + L H C LQ+L+L+ +TF + CQD
Sbjct: 857 ESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTF-NCCQD 915
Query: 721 ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISN 780
+ ++L NK L LDL + + D+GV LCEALK+P+C LQ L LE+C T CC +++
Sbjct: 916 MISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMAS 975
Query: 781 ALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPK 814
L ++Q L L+LS N + G+ LCEA K
Sbjct: 976 MLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQK 1009
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 586 bits (1510), Expect = e-167
Identities = 382/1039 (36%), Positives = 565/1039 (54%), Gaps = 85/1039 (8%)
Query: 13 FGLLLYLEELNKEELNTFKLFLKETMEPEHGLT--PWNEVKKARREDLANLMKKYYPGEK 70
F L LE+L+++EL+ FK +L T H L P EV KA + L ++ +
Sbjct: 9 FNLQALLEQLSQDELSKFK-YLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYW 67
Query: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQ---------TIG------------------ 103
SL++F KM+ DL ERAK+E+ +A ++G
Sbjct: 68 VEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERF 127
Query: 104 PDDAKA-GETQED-----QEAVLGDGTEYRNR----IKEKFCITWDKKSLAGKPEDFHHG 153
+A+A ET+ + +E G + NR +K KF W KS G ++
Sbjct: 128 KTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMW--KSWPGDSKEVQ-- 183
Query: 154 IAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYV 213
+ + K+L + V G VVL G AG+GKTTL +K MLDWAE +L +FKY
Sbjct: 184 VMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH-KFKYA 242
Query: 214 FYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEF 273
FYL+ RE+++L SFA+L+ +DWP + I I+ Q +LF+ID FDEL A
Sbjct: 243 FYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGALIE 302
Query: 274 ALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSED 333
+C DW ++ PV L+ SLL +VMLP+A+LLVTTR + L+ L + Y+ + G E+
Sbjct: 303 DICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEE 362
Query: 334 AREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTC 393
R Y + F D+ AM+ F ++SN LF + P VCW CT LK QMEKG D TC
Sbjct: 363 DRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTC 422
Query: 394 QTTTALFTCYISSLFTPVDGGSPSLPNQAQ----LRRLCQVAAKGIWTMTYVFYRENLRR 449
T T LF ++ S F P AQ LR L +AA+G+W T V +RE+L R
Sbjct: 423 LTRTGLFLRFLCSRF----------PQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLER 472
Query: 450 LGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYML-KGSWEAGNPSCQPF 508
LG+ +SD+ F+D +I+++D + CY F HL Q+F A+FY L K E +
Sbjct: 473 LGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDI 532
Query: 509 EDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVL 567
D++ LL ++P L Q + FGL NE R K+LE TF C+MS IK +LL+C ++
Sbjct: 533 GDVQKLLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRC-DIS 591
Query: 568 GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIHLLVSSFCLKHCRC 627
+S + EL CLYE+Q++ + + M F ++++++ + ++ SSFC+KHCR
Sbjct: 592 CKGGHS-TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRN 649
Query: 628 LRTIRLSVTVVFEKKILKTSLPTN------------TWDGDRITHCWQDLCSVLHTNEHL 675
L+ + L +++K +LP N + D + W DLCS+ +N+ L
Sbjct: 650 LQKMSL--------QVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDL 701
Query: 676 RELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHLD 735
L + S L S + IL ++ C LQ+++ K I+ D +++ +L +K + +L
Sbjct: 702 MGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLT 761
Query: 736 LKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLST 795
L+G+D D+ +LCE L+HPEC L+ L L SC+ T ++S AL +QSL +NLS
Sbjct: 762 LQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSD 820
Query: 796 NNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVL 855
N LLD+G +LL LRHPKC+L+RLSLE+C LTEA C+ L+ L+ ++ LTHLCLA N +
Sbjct: 821 NELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPI 880
Query: 856 GDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDN 915
G+ GVK + + L++ +C L++LVL C TS L+ L SL LDLG N +
Sbjct: 881 GNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVK 940
Query: 916 GVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVK 975
G+K LC+ R P CNL+ L L GC + C DL S + N +L +LDLG N L GVK
Sbjct: 941 GMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVK 1000
Query: 976 ILCDALRYPNCNIQRLGLE 994
+L + L + ++ L L+
Sbjct: 1001 MLFETLTCSSGTLRTLRLK 1019
Score = 32.3 bits (72), Expect = 2.5
Identities = 20/54 (37%), Positives = 27/54 (50%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD 716
+DLCS L N+ L LDL + L S + +L L + L+ L LK F D
Sbjct: 972 EDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 576 bits (1484), Expect = e-164
Identities = 366/1007 (36%), Positives = 538/1007 (53%), Gaps = 41/1007 (4%)
Query: 12 DFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKKYYPGEK 70
++ L LE+LN++EL +FK L +E TPW+EV++A + LA ++
Sbjct: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
Query: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQE-AVLGDGTEYRNR 129
+ ++ I +MNL +LC+ AK E+ Q D+ + G+ +ED E A G+ +RN
Sbjct: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNS 126
Query: 130 IKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGK 189
+ EK + W G ++FH + ++++ + L + P VVL G AGVGK
Sbjct: 127 M-EKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFL-NPRTPRKLTPYTVVLHGPAGVGK 184
Query: 190 TTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMY 249
TTL +K MLDW + +L +Y FYL+ +E++++ SFA+LISKDWP + I I+
Sbjct: 185 TTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILA 243
Query: 250 QPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL 309
Q +LF++D DEL +C DW ++ PV L+ SLL++ MLP A+LLVTTR
Sbjct: 244 QAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP 303
Query: 310 TTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVP 369
+ L+ L + YV + G E+ R Y + F D+ AM+ F ++SN LF + P
Sbjct: 304 RALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAP 363
Query: 370 LVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLR---- 425
VCW CT LK QMEKG D TC T T LF ++ S F P AQLR
Sbjct: 364 AVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF----------PQGAQLRGALR 413
Query: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
L +AA+G+W VF+RE+L RLG+ +SD+ F+D +I+++D + CY F HL Q+
Sbjct: 414 TLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ 473
Query: 486 FFAAMFYML-KGSWEAGNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQ 543
F A+FY L K E + D++ LL K+P L Q+ FLFGL NE R K+
Sbjct: 474 FLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKE 533
Query: 544 LERTFNCKMSLKIKSKLLQCMEVL-GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCF 602
LE TF C+MS IK +LLQC L N S + L E+ CLYE+Q++ + F
Sbjct: 534 LEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK--EVLGCLYESQEEELAKVVVAPF 591
Query: 603 PKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVT--------------VVFEKKILKTSL 648
+++I++ ++ SF LKHC+ L+ + L V + FE+ T +
Sbjct: 592 KEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT-I 650
Query: 649 PTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLL 708
P R W D CS+ +N +L+ L++ S L S++ IL + C LQK+
Sbjct: 651 PNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVE 710
Query: 709 LKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVK-SLCEALKHPECKLQTLRLES 767
+K +T +D + I K L HL L G + + LC+ L++ +C LQ LRL
Sbjct: 711 IKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGG 770
Query: 768 CNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGL 827
T L +QSL L LS N LLD+G LL + + PK +L+ LSLE+C L
Sbjct: 771 HCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRL 830
Query: 828 TEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSL 887
TEA C+ L+ L+ +K+LTHLCLA N +GD GVK + + L + C L++LVL++C T L
Sbjct: 831 TEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKL 890
Query: 888 SSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCL 947
YLS +L SLT+LDL N + G+ +LC +P+CNL+ L L C L C
Sbjct: 891 GCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQ 949
Query: 948 DLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLE 994
L S +L+N L +LDLG N L G+ L LR +++ L L+
Sbjct: 950 HLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLK 996
Score = 142 bits (358), Expect = 2e-33
Identities = 125/390 (32%), Positives = 177/390 (45%), Gaps = 70/390 (17%)
Query: 750 CEALKHPECKLQTLRLESCNL-TVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCE 808
C L P Q LR S L T FC L SN+ +L FL + + L D V++LC+
Sbjct: 645 CTYLTIPNWARQDLR--SLRLWTDFCSLFSSNS-----NLKFLEVKQSFLSDSSVRILCD 697
Query: 809 ALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLM-SDAL 867
+ C+L+++ +++ A ++ LA I K LTHL LA ++ + + LM D L
Sbjct: 698 HVTRSTCHLQKVEIKNVTPDTAYRDFC-LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLL 756
Query: 868 QHAQCTLKSLVLR-RCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRH 926
++ +C L+ L L C +E+ L N+SL HL L +N L D G LL
Sbjct: 757 RNHKCNLQYLRLGGHCATPEQWAEFFYV-LKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
Query: 927 PSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNC 986
P LQ L L C LT A C DLA+V++ + L L L N + D GVK LC+ L YP+C
Sbjct: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
Query: 987 NIQRLGLEYCGLTSLCCQDLSSAL------------------------------ICNKRL 1016
+Q L L+ C +T L C+ LS AL CN +
Sbjct: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKH 935
Query: 1017 IKM--------------------------NLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
+++ +L QN L GI+KL+ VL+ L++L L
Sbjct: 936 LRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRL 995
Query: 1051 CKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
+ E +KLLE V NP L I DCN
Sbjct: 996 KTYETNLEIKKLLEEVKEKNPKLTI--DCN 1023
Score = 40.0 bits (92), Expect = 0.012
Identities = 32/111 (28%), Positives = 54/111 (48%), Gaps = 9/111 (8%)
Query: 658 ITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF-PD 716
++ Q+ CS L LDL + + + IL L +PNC L+ L L + P
Sbjct: 895 LSEALQEACS-------LTNLDLSINQIARGLW-ILCQALENPNCNLKHLRLWSCSLMPF 946
Query: 717 GCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLES 767
CQ + ++L+ N+ L LDL + + +G+ L L+ L+ LRL++
Sbjct: 947 YCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKT 997
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 573 bits (1478), Expect = e-163
Identities = 364/982 (37%), Positives = 529/982 (53%), Gaps = 103/982 (10%)
Query: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPGEKAW 72
L YLE+L +L FK+ L E P+ G P + +KA DLA LM + EKAW
Sbjct: 10 LARYLEDLEDVDLKKFKMHL-EDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 73 SVSLKIFGKMNLKDLCERAK-EEINWSAQTIGPDDAKAGET----QED--QEAVLG---- 121
++++ IF +N +DL E+AK +E W G D+A+ QED +E +G
Sbjct: 69 AMAVWIFAAINRRDLYEKAKRDEPKW-----GSDNARVSNPTVICQEDSIEEEWMGLLEY 123
Query: 122 ------------DGTEYRNRIKEKFCITWDKKSLAGKPEDF------------HHGIAEK 157
+YR ++ +F D+ + G+ H E+
Sbjct: 124 LSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQER 183
Query: 158 DRKLL-----------------EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDW 200
+++LL E LFD D + VV QGAAG+GKT L RK MLDW
Sbjct: 184 EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDW 243
Query: 201 AEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDS 260
A G+LYQ RF Y+FY++ RE++ + +RS LI P PI +I+ +PS +LF++D
Sbjct: 244 ASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDG 303
Query: 261 FDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLK 320
FDEL AF+E LC DW + L+SSL+RK +LPEASLL+TTR ++L+ LL
Sbjct: 304 FDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLD 363
Query: 321 NHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK 380
+ +VE+LG SE R+EY +++F D+ A FS ++ NE+LF+MC +PLVCW CT LK
Sbjct: 364 HPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLK 423
Query: 381 QQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTY 440
QQME G + T +TTTA++ ++SSL P GGS A L LC +AA GIW
Sbjct: 424 QQMESGKSLAQTSKTTTAVYVFFLSSLLQP-RGGSQEHGLCAHLWGLCSLAADGIWNQKI 482
Query: 441 VFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEA 500
+F +LR GL ++DVS+F+ N+ QK+ + E Y F H+ QEFFAAM+Y+L+ E
Sbjct: 483 LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG 542
Query: 501 -----GNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
G+ P D+ LL++ ++ +L + FLFGL+N++R LE+ +CK+S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
+I+ +LL+ +EV + Q LELF+CLYE Q++ F+ +AM FPK+ IN+ ++
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674
+VSSFC+++C + ++ L ++P + ++
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL---------HNMPKEEEEEEK----------------E 697
Query: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734
R LD+ L S+ H L C L + C DIS L N+ L+ L
Sbjct: 698 GRHLDMVQCVLPSSSHAACSHGLGR--CGLSH---------ECCFDISLVLSSNQKLVEL 746
Query: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
DL + +GD G++ LC LKH C L+ L L SC LT CC ++++ L S SL L +
Sbjct: 747 DLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVG 806
Query: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854
N L D GV +LCE ++P+C L++L L + GLT C LS L +N+ LTHL L N
Sbjct: 807 ENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNT 866
Query: 855 LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914
LGD G+KL+ + L H C L+ L L C+ TS LST L ++SL L LG+N L D
Sbjct: 867 LGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGD 926
Query: 915 NGVKLLCDVFRHPSCNLQDLEL 936
GV + C+V + SC LQ+L L
Sbjct: 927 LGVMMFCEVLKQQSCLLQNLGL 948
Score = 198 bits (504), Expect = 2e-50
Identities = 113/275 (41%), Positives = 158/275 (57%), Gaps = 3/275 (1%)
Query: 801 DGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGV 860
D VQ + + H C L CGL+ C +SL L SN++L L L+DN LGD G+
Sbjct: 702 DMVQCVLPSSSHAAC---SHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
Query: 861 KLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLL 920
+L+ L+H C LK L L C TS + L++ L + SLT L +G N L D+GV +L
Sbjct: 759 RLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAIL 818
Query: 921 CDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDA 980
C+ ++P CNLQ L L+ LT+ CC L+SV+ N NL L L N L D G+K+LC+
Sbjct: 819 CEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
Query: 981 LRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKS 1040
L +P+C +Q L L+ C LTS CC DLS+ L ++ L K++L N LG G++ +VLK
Sbjct: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
Query: 1041 PKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
C LQ LGL + F+ E + LE + P L +
Sbjct: 939 QSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
Score = 189 bits (481), Expect = 9e-48
Identities = 111/284 (39%), Positives = 160/284 (56%), Gaps = 21/284 (7%)
Query: 719 QDISTSLIHN---------KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCN 769
+ +S +HN K HLD+ V+ + + H C + L C
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDM---------VQCVLPSSSHAAC---SHGLGRCG 724
Query: 770 LTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
L+ CC +IS L +Q L+ L+LS N L D G++LLC L+H C L++L L SC LT
Sbjct: 725 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTS 784
Query: 830 AGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSS 889
A C+ L+ L ++ LT L + +N LGD GV ++ + ++ QC L+ L L TS+
Sbjct: 785 ACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCC 844
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
LS+ L N++LTHL L N L D G+KLLC+ HP C LQ LEL C LT+ CC DL
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGL 993
++++ ++ +LR L LGNNDL D GV + C+ L+ +C +Q LGL
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 570 bits (1469), Expect = e-162
Identities = 361/982 (36%), Positives = 532/982 (54%), Gaps = 103/982 (10%)
Query: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPGEKAW 72
L YLE+L +L FK+ L E P+ G P + +KA DLA LM + EKAW
Sbjct: 10 LARYLEDLEDVDLKKFKMHL-EDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 73 SVSLKIFGKMNLKDLCERAK-EEINWSAQTIGPDDAKAGET----QED--QEAVLG---- 121
++++ IF +N +DL E+AK +E W G D+A+ QED +E +G
Sbjct: 69 AMAVWIFAAINRRDLYEKAKRDEPKW-----GSDNARVSNPTVICQEDSIEEEWMGLLEY 123
Query: 122 ------------DGTEYRNRIKEKFCITWDKKSLAGKPEDF------------HHGIAEK 157
+YR ++ +F D+ + G+ H E+
Sbjct: 124 LSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQER 183
Query: 158 DRKLL-----------------EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDW 200
+++LL E LFD D + VV QGAAG+GKT L RK MLDW
Sbjct: 184 EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDW 243
Query: 201 AEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDS 260
A G+LYQ RF Y+FY++ RE++ + +RS LI P PI +I+ +PS +LF++D
Sbjct: 244 ASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDG 303
Query: 261 FDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLK 320
FDEL AF+E LC DW + L+SSL+RK +LPEASLL+TTR ++L+ LL
Sbjct: 304 FDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLD 363
Query: 321 NHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK 380
+ +VE+LG SE R+EY +++F D+ A FS ++ NE+LF+MC +PLVCW CT LK
Sbjct: 364 HPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLK 423
Query: 381 QQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTY 440
QQME G + T +TTTA++ ++SSL P GGS A L LC +AA GIW
Sbjct: 424 QQMESGKSLAQTSKTTTAVYVFFLSSLLQP-RGGSQEHGLCAHLWGLCSLAADGIWNQKI 482
Query: 441 VFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEA 500
+F +LR GL ++DVS+F+ N+ QK+ + E Y F H+ QEFFAAM+Y+L+ E
Sbjct: 483 LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG 542
Query: 501 -----GNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
G+ P D+ LL++ ++ +L + FLFGL+N++R LE+ +CK+S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
+I+ +LL+ +EV + Q LELF+CLYE Q++ F+ +AM FPK+ IN+ ++
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEH 674
+VSSFC+++C + ++ L ++P + ++
Sbjct: 663 HMVSSFCIENCHRVESLSLGFL---------HNMPKEEEEEEK----------------E 697
Query: 675 LRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTSLIHNKNLMHL 734
R LD+ L S+ H L + + L F C+ + + L +++L L
Sbjct: 698 GRHLDMVQCVLPSSSHAACSHGLVNSH-----LTSSF------CRGLFSVLSTSQSLTEL 746
Query: 735 DLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLS 794
DL + +GD G++ LCE L+HP C ++ L L C L+ CC +IS L +Q L+ L+LS
Sbjct: 747 DLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLS 806
Query: 795 TNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNV 854
N L D G++LLC L+H C L++L L + GLT C LS L +N+ LTHL L N
Sbjct: 807 DNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNT 866
Query: 855 LGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQD 914
LGD G+KL+ + L H C L+ L L C+ TS LST L ++SL L LG+N L D
Sbjct: 867 LGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGD 926
Query: 915 NGVKLLCDVFRHPSCNLQDLEL 936
GV + C+V + SC LQ+L L
Sbjct: 927 LGVMMFCEVLKQQSCLLQNLGL 948
Score = 196 bits (499), Expect = 8e-50
Identities = 115/284 (40%), Positives = 162/284 (57%), Gaps = 21/284 (7%)
Query: 719 QDISTSLIHN---------KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCN 769
+ +S +HN K HLD+ V+ + + H C + L + +
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDM---------VQCVLPSSSHAAC---SHGLVNSH 724
Query: 770 LTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
LT C + + L SQSL L+LS N+L D G+++LCE L+HP C + RL L CGL+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 830 AGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSS 889
C +SL L SN++L L L+DN LGD G++L+ L+H C LK L L TS+
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 844
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
LS+ L N++LTHL L N L D G+KLLC+ HP C LQ LEL C LT+ CC DL
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGL 993
++++ ++ +LR L LGNNDL D GV + C+ L+ +C +Q LGL
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 181 bits (460), Expect = 3e-45
Identities = 106/275 (38%), Positives = 152/275 (55%), Gaps = 3/275 (1%)
Query: 801 DGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGV 860
D VQ + + H C L + LT + C L L +++ LT L L+DN LGD G+
Sbjct: 702 DMVQCVLPSSSHAAC---SHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGM 758
Query: 861 KLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLL 920
+++ + LQH C ++ L L RC + +S L N+ L LDL N L D G++LL
Sbjct: 759 RVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLL 818
Query: 921 CDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDA 980
C +H CNL+ L L+ LT+ CC L+SV+ N NL L L N L D G+K+LC+
Sbjct: 819 CVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
Query: 981 LRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKS 1040
L +P+C +Q L L+ C LTS CC DLS+ L ++ L K++L N LG G++ +VLK
Sbjct: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
Query: 1041 PKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
C LQ LGL + F+ E + LE + P L +
Sbjct: 939 QSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 560 bits (1444), Expect = e-159
Identities = 360/994 (36%), Positives = 530/994 (53%), Gaps = 43/994 (4%)
Query: 12 DFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKKYYPGEK 70
++ L LE+LN++EL +FK L +E TPW+EV++A + LA ++
Sbjct: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
Query: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQE-AVLGDGTEYRNR 129
+ ++ I +MNL +LC+ AK E+ Q D+ + G+ +ED E A G+ +RN
Sbjct: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNS 126
Query: 130 IKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGK 189
+ EK + W G ++FH + ++++ + L + P VVL G AGVGK
Sbjct: 127 M-EKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFL-NPRTPRKLTPYTVVLHGPAGVGK 184
Query: 190 TTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMY 249
TTL +K MLDW + +L +Y FYL+ +E++++ SFA+LISKDWP + I I+
Sbjct: 185 TTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILA 243
Query: 250 QPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL 309
Q +LF++D DEL +C DW ++ PV L+ SLL++ MLP A+LLVTTR
Sbjct: 244 QAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP 303
Query: 310 TTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVP 369
+ L+ L + YV + G E+ R Y + F D+ AM+ F ++SN LF + P
Sbjct: 304 RALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAP 363
Query: 370 LVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLR---- 425
VCW CT LK QMEKG D TC T T LF ++ S F P AQLR
Sbjct: 364 AVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF----------PQGAQLRGALR 413
Query: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
L +AA+G+W VF+RE+L RLG+ +SD+ F+D +I+++D + CY F HL Q+
Sbjct: 414 TLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ 473
Query: 486 FFAAMFYML-KGSWEAGNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQ 543
F A+FY L K E + D++ LL K+P L Q+ FLFGL NE R K+
Sbjct: 474 FLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKE 533
Query: 544 LERTFNCKMSLKIKSKLLQCMEVL-GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCF 602
LE TF C+MS IK +LLQC L N S + L E+ CLYE+Q++ + F
Sbjct: 534 LEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK--EVLGCLYESQEEELAKVVVAPF 591
Query: 603 PKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTV-VFEKKILKTSLPTNTWDGDRITHC 661
+++I++ ++ SF LKHC+ L+ + L V VF + + L
Sbjct: 592 KEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFES------- 644
Query: 662 WQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDI 721
+N +L+ L++ S L S++ IL + C LQK+ +K +T +D
Sbjct: 645 ---------SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 695
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVK-SLCEALKHPECKLQTLRLESCNLTVFCCLNISN 780
+ I K L HL L G + + LC+ L++ +C LQ LRL T
Sbjct: 696 CLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY 755
Query: 781 ALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALI 840
L +QSL L LS N LLD+G LL + + PK +L+ LSLE+C LTEA C+ L+ L+
Sbjct: 756 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 815
Query: 841 SNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNK 900
+K+LTHLCLA N +GD GVK + + L + C L++LVL++C T L YLS +L
Sbjct: 816 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 875
Query: 901 SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLR 960
SLT+LDL N + G+ +LC +P+CNL+ L L C L C L S +L+N L
Sbjct: 876 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLE 934
Query: 961 SLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLE 994
+LDLG N L G+ L LR +++ L L+
Sbjct: 935 TLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLK 968
Score = 187 bits (474), Expect = 6e-47
Identities = 140/417 (33%), Positives = 210/417 (50%), Gaps = 25/417 (5%)
Query: 676 RELDLYHSNLDKSAMNILHHELRHPNCK-LQKLLLKFI--TFPDGCQDISTSL---IHNK 729
+E+ ++ +N + ++H +C+ LQKL L+ F + D + N
Sbjct: 592 KEISIHLTNTSE----VMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFESSNS 647
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTV----FCCLNISNALIRS 785
NL L++K S + D+ V+ LC+ + C LQ + +++ FC A I
Sbjct: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCL-----AFIGK 702
Query: 786 QSLIFLNLSTNNLLDDGVQL-LCEALRHPKCYLERLSLES-CGLTEAGCEYLSLALISNK 843
++L L L+ + + + L LC+ LR+ KC L+ L L C E E+ + L +N+
Sbjct: 703 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV-LKANQ 761
Query: 844 RLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLT 903
L HL L+ NVL D G L+ + + L+ L L C T S + L+ L+ +K LT
Sbjct: 762 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 821
Query: 904 HLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLD 963
HL L N + D GVK LC+ +P C LQ L L C +T C L+ + +L +LD
Sbjct: 822 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 881
Query: 964 LGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQ 1023
L N + G+ ILC AL PNCN++ L L C L CQ L SAL+ N++L ++L Q
Sbjct: 882 LSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQ 940
Query: 1024 NTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
N L GI+KL+ VL+ L++L L + E +KLLE V NP L I DCN
Sbjct: 941 NHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI--DCN 995
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 547 bits (1409), Expect = e-155
Identities = 346/949 (36%), Positives = 510/949 (53%), Gaps = 41/949 (4%)
Query: 12 DFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKKYYPGEK 70
++ L LE+LN++EL +FK L +E TPW+EV++A + LA ++
Sbjct: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
Query: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQE-AVLGDGTEYRNR 129
+ ++ I +MNL +LC+ AK E+ Q D+ + G+ +ED E A G+ +RN
Sbjct: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNS 126
Query: 130 IKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGK 189
+ EK + W G ++FH + ++++ + L + P VVL G AGVGK
Sbjct: 127 M-EKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFL-NPRTPRKLTPYTVVLHGPAGVGK 184
Query: 190 TTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMY 249
TTL +K MLDW + +L +Y FYL+ +E++++ SFA+LISKDWP + I I+
Sbjct: 185 TTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILA 243
Query: 250 QPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL 309
Q +LF++D DEL +C DW ++ PV L+ SLL++ MLP A+LLVTTR
Sbjct: 244 QAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP 303
Query: 310 TTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVP 369
+ L+ L + YV + G E+ R Y + F D+ AM+ F ++SN LF + P
Sbjct: 304 RALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAP 363
Query: 370 LVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLR---- 425
VCW CT LK QMEKG D TC T T LF ++ S F P AQLR
Sbjct: 364 AVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF----------PQGAQLRGALR 413
Query: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
L +AA+G+W VF+RE+L RLG+ +SD+ F+D +I+++D + CY F HL Q+
Sbjct: 414 TLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ 473
Query: 486 FFAAMFYML-KGSWEAGNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQ 543
F A+FY L K E + D++ LL K+P L Q+ FLFGL NE R K+
Sbjct: 474 FLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKE 533
Query: 544 LERTFNCKMSLKIKSKLLQCMEVL-GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCF 602
LE TF C+MS IK +LLQC L N S + L E+ CLYE+Q++ + F
Sbjct: 534 LEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK--EVLGCLYESQEEELAKVVVAPF 591
Query: 603 PKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVT--------------VVFEKKILKTSL 648
+++I++ ++ SF LKHC+ L+ + L V + FE+ T +
Sbjct: 592 KEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT-I 650
Query: 649 PTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLL 708
P R W D CS+ +N +L+ L++ S L S++ IL + C LQK+
Sbjct: 651 PNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVE 710
Query: 709 LKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVK-SLCEALKHPECKLQTLRLES 767
+K +T +D + I K L HL L G + + LC+ L++ +C LQ LRL
Sbjct: 711 IKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGG 770
Query: 768 CNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGL 827
T L +QSL L LS N LLD+G LL + + PK +L+ LSLE+C L
Sbjct: 771 HCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRL 830
Query: 828 TEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSL 887
TEA C+ L+ L+ +K+LTHLCLA N +GD GVK + + L + C L++LVL++C T L
Sbjct: 831 TEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKL 890
Query: 888 SSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLEL 936
YLS +L SLT+LDL N + G+ +LC +P+CNL+ L L
Sbjct: 891 GCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
Score = 155 bits (393), Expect = 2e-37
Identities = 121/334 (36%), Positives = 172/334 (51%), Gaps = 15/334 (4%)
Query: 750 CEALKHPECKLQTLRLESCNL-TVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCE 808
C L P Q LR S L T FC L SN+ +L FL + + L D V++LC+
Sbjct: 645 CTYLTIPNWARQDLR--SLRLWTDFCSLFSSNS-----NLKFLEVKQSFLSDSSVRILCD 697
Query: 809 ALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLM-SDAL 867
+ C+L+++ +++ A ++ LA I K LTHL LA ++ + + LM D L
Sbjct: 698 HVTRSTCHLQKVEIKNVTPDTAYRDFC-LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLL 756
Query: 868 QHAQCTLKSLVLR-RCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRH 926
++ +C L+ L L C +E+ L N+SL HL L +N L D G LL
Sbjct: 757 RNHKCNLQYLRLGGHCATPEQWAEFFYV-LKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
Query: 927 PSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNC 986
P LQ L L C LT A C DLA+V++ + L L L N + D GVK LC+ L YP+C
Sbjct: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
Query: 987 NIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQ 1046
+Q L L+ C +T L C+ LS AL L ++L+ N + G+ L + L++P C L+
Sbjct: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLK 934
Query: 1047 VLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
L L + E +KLLE V NP L I DCN
Sbjct: 935 HLRLKTYETNLEIKKLLEEVKEKNPKLTI--DCN 966
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/159 (29%), Positives = 84/159 (52%), Gaps = 12/159 (7%)
Query: 620 FCLKHCRCLRTIRLSVTVVFEKKIL---------KTSLPTNTWDGDRITHC-WQDLCSVL 669
+ LK + L+ +RLS V+ ++ + K L + + R+T +DL +VL
Sbjct: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
Query: 670 HTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDISTSLIHN 728
++ L L L + + + + L L +P+CKLQ L+L+ + GC+ +S +L
Sbjct: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
Query: 729 KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLES 767
+L +LDL + I G+ LC+AL++P C L+ LRL++
Sbjct: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKT 940
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 531 bits (1367), Expect = e-150
Identities = 332/889 (37%), Positives = 491/889 (55%), Gaps = 88/889 (9%)
Query: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPGEKAW 72
L YLE+L +L FK+ L E P+ G P + +KA DLA LM + EKAW
Sbjct: 10 LARYLEDLEDVDLKKFKMHL-EDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAW 68
Query: 73 SVSLKIFGKMNLKDLCERAK-EEINWSAQTIGPDDAKAGE----TQED--QEAVLG---- 121
++++ IF +N +DL E+AK +E W G D+A+ QED +E +G
Sbjct: 69 AMAVWIFAAINRRDLYEKAKRDEPKW-----GSDNARVSNPTVICQEDSIEEEWMGLLEY 123
Query: 122 ------------DGTEYRNRIKEKFCITWDKKSLAGKPEDF------------HHGIAEK 157
+YR ++ +F D+ + G+ H E+
Sbjct: 124 LSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQER 183
Query: 158 DRKLL-----------------EHLFDVDVKTGAQPQIVVLQGAAGVGKTTLVRKAMLDW 200
+++LL E LFD D + VV QGAAG+GKT L RK MLDW
Sbjct: 184 EQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDW 243
Query: 201 AEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMYQPSSLLFIIDS 260
A G+LYQ RF Y+FY++ RE++ + +RS LI P PI +I+ +PS +LF++D
Sbjct: 244 ASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDG 303
Query: 261 FDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRLTTSKRLKQLLK 320
FDEL AF+E LC DW + L+SSL+RK +LPEASLL+TTR ++L+ LL
Sbjct: 304 FDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLD 363
Query: 321 NHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVPLVCWAACTCLK 380
+ +VE+LG SE R+EY +++F D+ A FS ++ NE+LF+MC +PLVCW CT LK
Sbjct: 364 HPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLK 423
Query: 381 QQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLRRLCQVAAKGIWTMTY 440
QQME G + T +TTTA++ ++SSL P GGS A L LC +AA GIW
Sbjct: 424 QQMESGKSLAQTSKTTTAVYVFFLSSLLQP-RGGSQEHGLCAHLWGLCSLAADGIWNQKI 482
Query: 441 VFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQEFFAAMFYMLKGSWEA 500
+F +LR GL ++DVS+F+ N+ QK+ + E Y F H+ QEFFAAM+Y+L+ E
Sbjct: 483 LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG 542
Query: 501 -----GNPSCQPFEDLKSLLQS-TSYKDPHLTQMKCFLFGLLNEDRVKQLERTFNCKMSL 554
G+ P D+ LL++ ++ +L + FLFGL+N++R LE+ +CK+S
Sbjct: 543 RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ 602
Query: 555 KIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPKVAINICEKIH 614
+I+ +LL+ +EV + Q LELF+CLYE Q++ F+ +AM FPK+ IN+ ++
Sbjct: 603 QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD 662
Query: 615 LLVSSFCLKHCRCLRTIRLSVTVVFEKK------------ILKTSLPTNTWDGDR----- 657
+VSSFC+++C + ++ L K+ +++ LP+++
Sbjct: 663 HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGR 722
Query: 658 --ITH-CWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKL-LLKFIT 713
++H C D+ VL +N+ L ELDL + L + +L L+H C L+KL L+
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782
Query: 714 FPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
C +S+ L N+NL HL L+G+ +GD G+K LCE L HP+CKLQ L L++CNLT
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842
Query: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSL 822
CC ++S L SQSL L+L N+L D GV + CE L+ C L+ L L
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
Score = 154 bits (390), Expect = 3e-37
Identities = 85/193 (44%), Positives = 115/193 (59%), Gaps = 3/193 (1%)
Query: 801 DGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGV 860
D VQ + + H C L CGL+ C +SL L SN++L L L+DN LGD G+
Sbjct: 702 DMVQCVLPSSSHAAC---SHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGI 758
Query: 861 KLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLL 920
+L+ L+H C LK L L TS+ LS+ L N++LTHL L N L D G+KLL
Sbjct: 759 RLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLL 818
Query: 921 CDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDA 980
C+ HP C LQ LEL C LT+ CC DL++++ ++ +LR L LGNNDL D GV + C+
Sbjct: 819 CEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEV 878
Query: 981 LRYPNCNIQRLGL 993
L+ +C +Q LGL
Sbjct: 879 LKQQSCLLQNLGL 891
Score = 144 bits (364), Expect = 3e-34
Identities = 85/216 (39%), Positives = 119/216 (55%), Gaps = 3/216 (1%)
Query: 860 VKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKL 919
V+ + + HA C S L RC + +S L N+ L LDL N L D G++L
Sbjct: 704 VQCVLPSSSHAAC---SHGLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
Query: 920 LCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCD 979
LC +H CNL+ L L+ LT+ CC L+SV+ N NL L L N L D G+K+LC+
Sbjct: 761 LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 820
Query: 980 ALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLK 1039
L +P+C +Q L L+ C LTS CC DLS+ L ++ L K++L N LG G++ +VLK
Sbjct: 821 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 880
Query: 1040 SPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
C LQ LGL + F+ E + LE + P L +
Sbjct: 881 QQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 916
Score = 135 bits (341), Expect = 2e-31
Identities = 87/227 (38%), Positives = 120/227 (52%), Gaps = 21/227 (9%)
Query: 719 QDISTSLIHN---------KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCN 769
+ +S +HN K HLD+ V+ + + H C + L C
Sbjct: 677 ESLSLGFLHNMPKEEEEEEKEGRHLDM---------VQCVLPSSSHAAC---SHGLGRCG 724
Query: 770 LTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
L+ CC +IS L +Q L+ L+LS N L D G++LLC L+H C L++L L + GLT
Sbjct: 725 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTS 784
Query: 830 AGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSS 889
C LS L +N+ LTHL L N LGD G+KL+ + L H C L+ L L C+ TS
Sbjct: 785 VCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCC 844
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLEL 936
LST L ++SL L LG+N L D GV + C+V + SC LQ+L L
Sbjct: 845 WDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 515 bits (1326), Expect = e-145
Identities = 322/1001 (32%), Positives = 518/1001 (51%), Gaps = 42/1001 (4%)
Query: 1 MADSSSSSFFPDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLAN 60
MA+S S+ DF LL YLE L+ +E +FK +L + P + + +E+LAN
Sbjct: 1 MAESDST----DFDLLWYLENLSDKEFQSFKKYLARKILDFK--LPQFPLIQMTKEELAN 54
Query: 61 LMKKYYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVL 120
++ Y G+ W++ IF M +DLC + G +QEA
Sbjct: 55 VLPISYEGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEAC- 96
Query: 121 GDGTEYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVV 180
+ ++ KF + W+ + F ++ +L+ +D A V
Sbjct: 97 ------KAVMRRKFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLNVF 150
Query: 181 LQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPST 240
L G GKT ++ A+L W +G ++Q YV +L EINQ+ S A+LI+KDWP
Sbjct: 151 LMGERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDG 210
Query: 241 EGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPE 300
+ PI +I+ P LLFI++ D + F E ALC + TQ+ P+ L+ SLL++ M P
Sbjct: 211 QAPIADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPG 270
Query: 301 ASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNE 360
L+++R T +K LK L +S RE Y FF+D++ A + +E
Sbjct: 271 CWFLISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDE 330
Query: 361 MLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPN 420
+L +C+V ++CW CT LK+QM+KG D L CQT T L +++ T G + + +
Sbjct: 331 ILVGLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYH 390
Query: 421 QAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTH 480
L+RLC +AA G++ T F E+LR +G T++DVS +NI+ +++ Y F H
Sbjct: 391 LGLLKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIH 450
Query: 481 LHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDR 540
L+VQEF A+ +++ + +++ + Y D Q+ F+FGLLN +R
Sbjct: 451 LNVQEFCTAIAFLMAVPNYLIPSGSREYKEKRE-----QYSD--FNQVFTFIFGLLNANR 503
Query: 541 VKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQL-GFLELFHCLYETQDKAFISQAM 599
K LE +F ++ + + S + + + D P +L + LF+CLYE +++ F+ +
Sbjct: 504 RKILETSFGYQLPM-VDSFKWYSVGYMKHLDRDPEKLTHHMPLFYCLYENREEEFVKTIV 562
Query: 600 RCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRIT 659
+V + + ++VS +CL +C LRT++LSV +F+ K L T +
Sbjct: 563 DALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQRIFQN---KEPLIRPTASQMKSL 619
Query: 660 HCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQ 719
W+++CS+ +T E LREL ++ ++L+ + IL L H +CKL+ L L +++ G +
Sbjct: 620 VYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVSTASGFE 679
Query: 720 DISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNIS 779
D+ +L N++L +L + + I N L + L P C++ L L C+L C I+
Sbjct: 680 DLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIA 739
Query: 780 NALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839
+ LI SL L LS+N L DG+ +LC+AL HP C L L L C LTE C L L
Sbjct: 740 SLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVL 799
Query: 840 ISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHN 899
+ + L L L N L + GV ++ L C L+ L L C F+S +Y++ + N
Sbjct: 800 LFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATN 859
Query: 900 KSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
+ L L++GSN ++D G++LLC RHP+C L ++ L C+LT+ACC LASV+ N L
Sbjct: 860 EKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTL 919
Query: 960 RSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
L+L N L +DGV L ++L P+C ++ +GL GL +
Sbjct: 920 ERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNT 960
Score = 125 bits (315), Expect = 2e-28
Identities = 83/250 (33%), Positives = 122/250 (48%), Gaps = 2/250 (0%)
Query: 657 RITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD 716
R + C +++ S+L + LR+L L + L MNIL L HPNC L L+L F +
Sbjct: 731 RASEC-EEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTE 789
Query: 717 GC-QDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCC 775
C + L+ + L LDL + + + GV + L P C+L+ L L C + C
Sbjct: 790 NCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDIC 849
Query: 776 LNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYL 835
I+ + ++ L L + +N + D G+QLLC LRHP C L + LE C LT A C L
Sbjct: 850 QYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSL 909
Query: 836 SLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTS 895
+ L +NK L L L N LG+ GV + ++L C LK + L + + + L T
Sbjct: 910 ASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969
Query: 896 LLHNKSLTHL 905
SL L
Sbjct: 970 KERKPSLIFL 979
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 427 bits (1097), Expect = e-119
Identities = 257/656 (39%), Positives = 372/656 (56%), Gaps = 17/656 (2%)
Query: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234
+P+IV+LQGAAG+GK+TL R+ W G LY RF++VFY + RE+ Q K S A+LI
Sbjct: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
Query: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294
KD +T PI +I+ +P LLFI+D DE + +EP LC W+Q P L+ SLL
Sbjct: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
Query: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354
K +LPEAS L+T R T + L L+ +VE+LG SE +R+EY Y++F D+R A++ F
Sbjct: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
Query: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414
+KSN+ L+++C VP V W ACTCL QQM++ +TLT +TTT L Y++
Sbjct: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
Query: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474
+ P QLR LC +AA+GIW +F ++LR+ GL + +S+F+ I+Q +
Sbjct: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
Query: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534
Y F HL QEFFAAM Y+L+ G S DL+ L++ FL G
Sbjct: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
Query: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594
LL+++ +++E F+C++S L+Q + L Q LE HCLYET++K F
Sbjct: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
Query: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654
++Q M F ++ + + + LLV +FC+K R ++ ++L T + W
Sbjct: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
Query: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714
+ WQ L SVL +L+ELDL ++L SA+ L LR P C L+ L L
Sbjct: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
Query: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
+ C+D++ L N+ L LDL + + D G K LC+ L+ P CKLQ L+L SC LT
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
Query: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
CC ++++ L S SL L+L NNL D GV+LLCE LRHP C L RL L+ L++
Sbjct: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
Score = 134 bits (338), Expect = 4e-31
Identities = 79/186 (42%), Positives = 102/186 (54%)
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
+ L + L ++L LDL N L + VK LC R P C L+ L L GC LT C DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
A + N L LDL N L D G K LC LR P+C +QRL L CGLTS CCQDL+S
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069
L + L +++L QN L G+ L + L+ P CKL LGL + +E ++ L A+
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 1070 NPHLII 1075
P L+I
Sbjct: 978 KPQLLI 983
Score = 132 bits (332), Expect = 2e-30
Identities = 74/180 (41%), Positives = 105/180 (58%)
Query: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886
+T+A + L L + L L L+ N L VK + L+ +C L++L L C T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946
+ L+ L N++LT LDL N L D G K LC R PSC LQ L+L+ C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDL 1006
DLASV+ +P+L+ LDL N+L D GV++LC+ LR+P C + RLGL+ L+ Q+L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 114 bits (284), Expect = 7e-25
Identities = 69/175 (39%), Positives = 97/175 (55%)
Query: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
+++L L+LS N+L V+ LC+ LR P+C LE L L CGLT C+ L+ L +N+
Sbjct: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
Query: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
LT L L+ NVL D G K + L+ C L+ L L C TS + L++ L + SL
Sbjct: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
Query: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
LDL N L D GV+LLC+ RHP+C L L L L++ +L ++ P L
Sbjct: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQL 981
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Query: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
+T+A L SV+ NL+ LDL N L VK LC LR P C ++ L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060
C+DL+ L N+ L +++L+ N L G L + L+ P CKLQ L L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087
+ L +V ++P L + D +N +DV
Sbjct: 912 QDLASVLSASPSL-KELDLQQNNLDDV 937
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72
L YLE L KEEL F+L L K G TP K + E +A+ + Y ++AW
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
Query: 73 SVSLKIFGKMNLKDLCERAKE 93
++L + +M L+ LC +A+E
Sbjct: 68 DLALHTWEQMGLRSLCAQAQE 88
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 427 bits (1097), Expect = e-119
Identities = 257/656 (39%), Positives = 372/656 (56%), Gaps = 17/656 (2%)
Query: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234
+P+IV+LQGAAG+GK+TL R+ W G LY RF++VFY + RE+ Q K S A+LI
Sbjct: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
Query: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294
KD +T PI +I+ +P LLFI+D DE + +EP LC W+Q P L+ SLL
Sbjct: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
Query: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354
K +LPEAS L+T R T + L L+ +VE+LG SE +R+EY Y++F D+R A++ F
Sbjct: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
Query: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414
+KSN+ L+++C VP V W ACTCL QQM++ +TLT +TTT L Y++
Sbjct: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
Query: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474
+ P QLR LC +AA+GIW +F ++LR+ GL + +S+F+ I+Q +
Sbjct: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
Query: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534
Y F HL QEFFAAM Y+L+ G S DL+ L++ FL G
Sbjct: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
Query: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594
LL+++ +++E F+C++S L+Q + L Q LE HCLYET++K F
Sbjct: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
Query: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654
++Q M F ++ + + + LLV +FC+K R ++ ++L T + W
Sbjct: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
Query: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714
+ WQ L SVL +L+ELDL ++L SA+ L LR P C L+ L L
Sbjct: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
Query: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
+ C+D++ L N+ L LDL + + D G K LC+ L+ P CKLQ L+L SC LT
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
Query: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
CC ++++ L S SL L+L NNL D GV+LLCE LRHP C L RL L+ L++
Sbjct: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
Score = 134 bits (338), Expect = 4e-31
Identities = 79/186 (42%), Positives = 102/186 (54%)
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
+ L + L ++L LDL N L + VK LC R P C L+ L L GC LT C DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
A + N L LDL N L D G K LC LR P+C +QRL L CGLTS CCQDL+S
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069
L + L +++L QN L G+ L + L+ P CKL LGL + +E ++ L A+
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 1070 NPHLII 1075
P L+I
Sbjct: 978 KPQLLI 983
Score = 132 bits (332), Expect = 2e-30
Identities = 74/180 (41%), Positives = 105/180 (58%)
Query: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886
+T+A + L L + L L L+ N L VK + L+ +C L++L L C T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946
+ L+ L N++LT LDL N L D G K LC R PSC LQ L+L+ C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDL 1006
DLASV+ +P+L+ LDL N+L D GV++LC+ LR+P C + RLGL+ L+ Q+L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 114 bits (284), Expect = 7e-25
Identities = 69/175 (39%), Positives = 97/175 (55%)
Query: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
+++L L+LS N+L V+ LC+ LR P+C LE L L CGLT C+ L+ L +N+
Sbjct: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
Query: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
LT L L+ NVL D G K + L+ C L+ L L C TS + L++ L + SL
Sbjct: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
Query: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
LDL N L D GV+LLC+ RHP+C L L L L++ +L ++ P L
Sbjct: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQL 981
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Query: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
+T+A L SV+ NL+ LDL N L VK LC LR P C ++ L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060
C+DL+ L N+ L +++L+ N L G L + L+ P CKLQ L L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087
+ L +V ++P L + D +N +DV
Sbjct: 912 QDLASVLSASPSL-KELDLQQNNLDDV 937
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72
L YLE L KEEL F+L L K G TP K + E +A+ + Y ++AW
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
Query: 73 SVSLKIFGKMNLKDLCERAKE 93
++L + +M L+ LC +A+E
Sbjct: 68 DLALHTWEQMGLRSLCAQAQE 88
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 427 bits (1097), Expect = e-119
Identities = 257/656 (39%), Positives = 372/656 (56%), Gaps = 17/656 (2%)
Query: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234
+P+IV+LQGAAG+GK+TL R+ W G LY RF++VFY + RE+ Q K S A+LI
Sbjct: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
Query: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294
KD +T PI +I+ +P LLFI+D DE + +EP LC W+Q P L+ SLL
Sbjct: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
Query: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354
K +LPEAS L+T R T + L L+ +VE+LG SE +R+EY Y++F D+R A++ F
Sbjct: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
Query: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414
+KSN+ L+++C VP V W ACTCL QQM++ +TLT +TTT L Y++
Sbjct: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
Query: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474
+ P QLR LC +AA+GIW +F ++LR+ GL + +S+F+ I+Q +
Sbjct: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
Query: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534
Y F HL QEFFAAM Y+L+ G S DL+ L++ FL G
Sbjct: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
Query: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594
LL+++ +++E F+C++S L+Q + L Q LE HCLYET++K F
Sbjct: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
Query: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654
++Q M F ++ + + + LLV +FC+K R ++ ++L T + W
Sbjct: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
Query: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714
+ WQ L SVL +L+ELDL ++L SA+ L LR P C L+ L L
Sbjct: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
Query: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
+ C+D++ L N+ L LDL + + D G K LC+ L+ P CKLQ L+L SC LT
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
Query: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTE 829
CC ++++ L S SL L+L NNL D GV+LLCE LRHP C L RL L+ L++
Sbjct: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSD 965
Score = 134 bits (338), Expect = 4e-31
Identities = 79/186 (42%), Positives = 102/186 (54%)
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
+ L + L ++L LDL N L + VK LC R P C L+ L L GC LT C DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
A + N L LDL N L D G K LC LR P+C +QRL L CGLTS CCQDL+S
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVS 1069
L + L +++L QN L G+ L + L+ P CKL LGL + +E ++ L A+
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 1070 NPHLII 1075
P L+I
Sbjct: 978 KPQLLI 983
Score = 132 bits (332), Expect = 2e-30
Identities = 74/180 (41%), Positives = 105/180 (58%)
Query: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886
+T+A + L L + L L L+ N L VK + L+ +C L++L L C T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946
+ L+ L N++LT LDL N L D G K LC R PSC LQ L+L+ C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDL 1006
DLASV+ +P+L+ LDL N+L D GV++LC+ LR+P C + RLGL+ L+ Q+L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Score = 114 bits (284), Expect = 7e-25
Identities = 69/175 (39%), Positives = 97/175 (55%)
Query: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
+++L L+LS N+L V+ LC+ LR P+C LE L L CGLT C+ L+ L +N+
Sbjct: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
Query: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
LT L L+ NVL D G K + L+ C L+ L L C TS + L++ L + SL
Sbjct: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
Query: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
LDL N L D GV+LLC+ RHP+C L L L L++ +L ++ P L
Sbjct: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKPQL 981
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Query: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
+T+A L SV+ NL+ LDL N L VK LC LR P C ++ L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060
C+DL+ L N+ L +++L+ N L G L + L+ P CKLQ L L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087
+ L +V ++P L + D +N +DV
Sbjct: 912 QDLASVLSASPSL-KELDLQQNNLDDV 937
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72
L YLE L KEEL F+L L K G TP K + E +A+ + Y ++AW
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
Query: 73 SVSLKIFGKMNLKDLCERAKE 93
++L + +M L+ LC +A+E
Sbjct: 68 DLALHTWEQMGLRSLCAQAQE 88
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 423 bits (1088), Expect = e-118
Identities = 256/651 (39%), Positives = 368/651 (56%), Gaps = 17/651 (2%)
Query: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234
+P+IV+LQGAAG+GK+TL R+ W G LY RF++VFY + RE+ Q K S A+LI
Sbjct: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
Query: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294
KD +T PI +I+ +P LLFI+D DE + +EP LC W+Q P L+ SLL
Sbjct: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
Query: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354
K +LPEAS L+T R T + L L+ +VE+LG SE +R+EY Y++F D+R A++ F
Sbjct: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
Query: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414
+KSN+ L+++C VP V W ACTCL QQM++ +TLT +TTT L Y++
Sbjct: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
Query: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474
+ P QLR LC +AA+GIW +F ++LR+ GL + +S+F+ I+Q +
Sbjct: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
Query: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534
Y F HL QEFFAAM Y+L+ G S DL+ L++ FL G
Sbjct: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
Query: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594
LL+++ +++E F+C++S L+Q + L Q LE HCLYET++K F
Sbjct: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
Query: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654
++Q M F ++ + + + LLV +FC+K R ++ ++L T + W
Sbjct: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
Query: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714
+ WQ L SVL +L+ELDL ++L SA+ L LR P C L+ L L
Sbjct: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
Query: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
+ C+D++ L N+ L LDL + + D G K LC+ L+ P CKLQ L+L SC LT
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
Query: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLES 824
CC ++++ L S SL L+L NNL D GV+LLCE LRHP C L RL S
Sbjct: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
Score = 128 bits (321), Expect = 3e-29
Identities = 70/166 (42%), Positives = 98/166 (59%)
Query: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886
+T+A + L L + L L L+ N L VK + L+ +C L++L L C T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946
+ L+ L N++LT LDL N L D G K LC R PSC LQ L+L+ C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLG 992
DLASV+ +P+L+ LDL N+L D GV++LC+ LR+P C + RLG
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 124 bits (310), Expect = 6e-28
Identities = 72/160 (45%), Positives = 89/160 (55%)
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
+ L + L ++L LDL N L + VK LC R P C L+ L L GC LT C DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
A + N L LDL N L D G K LC LR P+C +QRL L CGLTS CCQDL+S
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLG 1049
L + L +++L QN L G+ L + L+ P CKL LG
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 111 bits (278), Expect = 3e-24
Identities = 71/182 (39%), Positives = 100/182 (54%), Gaps = 1/182 (0%)
Query: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
+++L L+LS N+L V+ LC+ LR P+C LE L L CGLT C+ L+ L +N+
Sbjct: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
Query: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
LT L L+ NVL D G K + L+ C L+ L L C TS + L++ L + SL
Sbjct: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
Query: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
LDL N L D GV+LLC+ RHP+C L L V+T LD + + +L+ L
Sbjct: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLG-KPSVMTPTEGLDTGEMSNSTSSLKRQRL 985
Query: 965 GN 966
G+
Sbjct: 986 GS 987
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Query: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
+T+A L SV+ NL+ LDL N L VK LC LR P C ++ L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060
C+DL+ L N+ L +++L+ N L G L + L+ P CKLQ L L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087
+ L +V ++P L + D +N +DV
Sbjct: 912 QDLASVLSASPSL-KELDLQQNNLDDV 937
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72
L YLE L KEEL F+L L K G TP K + E +A+ + Y ++AW
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
Query: 73 SVSLKIFGKMNLKDLCERAKE 93
++L + +M L+ LC +A+E
Sbjct: 68 DLALHTWEQMGLRSLCAQAQE 88
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 423 bits (1088), Expect = e-118
Identities = 256/651 (39%), Positives = 368/651 (56%), Gaps = 17/651 (2%)
Query: 175 QPQIVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLIS 234
+P+IV+LQGAAG+GK+TL R+ W G LY RF++VFY + RE+ Q K S A+LI
Sbjct: 326 EPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSKVVSLAELIG 385
Query: 235 KDWPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLR 294
KD +T PI +I+ +P LLFI+D DE + +EP LC W+Q P L+ SLL
Sbjct: 386 KDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPADALLGSLLG 445
Query: 295 KVMLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFS 354
K +LPEAS L+T R T + L L+ +VE+LG SE +R+EY Y++F D+R A++ F
Sbjct: 446 KTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTDERQAIRAFR 505
Query: 355 SLKSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGG 414
+KSN+ L+++C VP V W ACTCL QQM++ +TLT +TTT L Y++
Sbjct: 506 LVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLAQAL------ 559
Query: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYEN 474
+ P QLR LC +AA+GIW +F ++LR+ GL + +S+F+ I+Q +
Sbjct: 560 -QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGILQ-EHPIPL 617
Query: 475 CYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFG 534
Y F HL QEFFAAM Y+L+ G S DL+ L++ FL G
Sbjct: 618 SYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDLEKTLEAYGIHGLFGASTTRFLLG 676
Query: 535 LLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAF 594
LL+++ +++E F+C++S L+Q + L Q LE HCLYET++K F
Sbjct: 677 LLSDEGEREMENIFHCRLSQ--GRNLMQWVPSL----QLLLQPHSLESLHCLYETRNKTF 730
Query: 595 ISQAMRCFPKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWD 654
++Q M F ++ + + + LLV +FC+K R ++ ++L T + W
Sbjct: 731 LTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKLQLIEGRQHRSTWSPTMVVLFRWV 790
Query: 655 GDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF 714
+ WQ L SVL +L+ELDL ++L SA+ L LR P C L+ L L
Sbjct: 791 PVTDAY-WQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGL 849
Query: 715 -PDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVF 773
+ C+D++ L N+ L LDL + + D G K LC+ L+ P CKLQ L+L SC LT
Sbjct: 850 TAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSD 909
Query: 774 CCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLES 824
CC ++++ L S SL L+L NNL D GV+LLCE LRHP C L RL S
Sbjct: 910 CCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPS 960
Score = 128 bits (321), Expect = 3e-29
Identities = 70/166 (42%), Positives = 98/166 (59%)
Query: 827 LTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTS 886
+T+A + L L + L L L+ N L VK + L+ +C L++L L C T+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 887 LSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACC 946
+ L+ L N++LT LDL N L D G K LC R PSC LQ L+L+ C LT+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 947 LDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLG 992
DLASV+ +P+L+ LDL N+L D GV++LC+ LR+P C + RLG
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 124 bits (310), Expect = 6e-28
Identities = 72/160 (45%), Positives = 89/160 (55%)
Query: 890 EYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDL 949
+ L + L ++L LDL N L + VK LC R P C L+ L L GC LT C DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 950 ASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSA 1009
A + N L LDL N L D G K LC LR P+C +QRL L CGLTS CCQDL+S
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 1010 LICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLG 1049
L + L +++L QN L G+ L + L+ P CKL LG
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 111 bits (278), Expect = 3e-24
Identities = 71/182 (39%), Positives = 100/182 (54%), Gaps = 1/182 (0%)
Query: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
+++L L+LS N+L V+ LC+ LR P+C LE L L CGLT C+ L+ L +N+
Sbjct: 807 TRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQT 866
Query: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
LT L L+ NVL D G K + L+ C L+ L L C TS + L++ L + SL
Sbjct: 867 LTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKE 926
Query: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
LDL N L D GV+LLC+ RHP+C L L V+T LD + + +L+ L
Sbjct: 927 LDLQQNNLDDVGVRLLCEGLRHPACKLIRLG-KPSVMTPTEGLDTGEMSNSTSSLKRQRL 985
Query: 965 GN 966
G+
Sbjct: 986 GS 987
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/147 (36%), Positives = 77/147 (52%), Gaps = 1/147 (0%)
Query: 941 LTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTS 1000
+T+A L SV+ NL+ LDL N L VK LC LR P C ++ L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 1001 LCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQ 1060
C+DL+ L N+ L +++L+ N L G L + L+ P CKLQ L L +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 1061 KLLEAVGVSNPHLIIKPDCNYHNEEDV 1087
+ L +V ++P L + D +N +DV
Sbjct: 912 QDLASVLSASPSL-KELDLQQNNLDDV 937
Score = 45.1 bits (105), Expect = 4e-04
Identities = 29/81 (35%), Positives = 43/81 (53%), Gaps = 3/81 (3%)
Query: 15 LLLYLEELNKEELNTFKLFL--KETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAW 72
L YLE L KEEL F+L L K G TP K + E +A+ + Y ++AW
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGME-VASYLVAQYGEQRAW 67
Query: 73 SVSLKIFGKMNLKDLCERAKE 93
++L + +M L+ LC +A+E
Sbjct: 68 DLALHTWEQMGLRSLCAQAQE 88
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 329 bits (843), Expect = 1e-89
Identities = 269/873 (30%), Positives = 418/873 (47%), Gaps = 85/873 (9%)
Query: 15 LLLYLEELNKEELNTFKLFLKETMEPEHGLTPWNEVKKARREDLANLMKKYYPGEKAWSV 74
LL LEEL++E+L F+ L++ + P+ PW +++A DLA + ++Y E A V
Sbjct: 22 LLAALEELSQEQLKRFRHKLRD-VGPDGRSIPWGRLERADAVDLAEQLAQFYGPEPALEV 80
Query: 75 SLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRNRIKE-- 132
+ K + + +D+ + +E Q +G E ++ + R+KE
Sbjct: 81 ARKTLKRADARDVAAQLQER---RLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKERN 137
Query: 133 ----KFCITWDKKSLA----------GKPEDFHHGIAEK-DRKLLEHLFDVDVKTGAQPQ 177
K + K +A G E+ G A + D LF D + G +P
Sbjct: 138 ARSVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRD-EEGRRPL 196
Query: 178 IVVLQGAAGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLN-GREINQLKERSFAQLISKD 236
VVLQG AG+GKT +K + DWA G LYQ + + F++ G + + RS A LI
Sbjct: 197 TVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQ 256
Query: 237 WPSTEGPIEEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKV 296
P P+ +++ QP LLFI+D DEL A PE A C D + + ++ LL K
Sbjct: 257 CPDRGAPVPQMLAQPQRLLFILDGADELP-ALGGPEAAPCTDPFEAASGARVLGGLLSKA 315
Query: 297 MLPEASLLVTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSL 356
+LP A LLVTTR RL+ L + E+ G S+ +++Y Y+FF D+R A + + +
Sbjct: 316 LLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFV 375
Query: 357 KSNEMLFSMCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFT--PVDGG 414
K NE LF++C VP VCW CT L+QQ+E G D++ T +TTT+++ +I+S+ + PV G
Sbjct: 376 KENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADG 435
Query: 415 SPSLPNQAQLRRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSS-FMDSNIIQKDAEYE 473
P L Q LR LC++A +G+ F + L +L L S V + F+ + E E
Sbjct: 436 -PRL--QGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETE 492
Query: 474 NCYVFTHLHVQEFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLF 533
Y F QEF AA+ Y+L E G + +LL+ + HL FLF
Sbjct: 493 VTYQFIDQSFQEFLAALSYLL----EDGGVPRTAAGGVGTLLRGDAQPHSHLVLTTRFLF 548
Query: 534 GLLNEDRVKQLERTFNCKMSLKIKSKLLQCMEVLGNS------DYSPSQLGF-------- 579
GLL+ +R++ +ER F C +S ++K + L+ ++ G + + G
Sbjct: 549 GLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEE 608
Query: 580 ----------LELFHCLYETQDKAFISQAMRCFPKVA---INICEKIHLLVSSFCLKHC- 625
LEL +CLYETQ+ AF+ QA+ FP++A + C ++ + V S+C++ C
Sbjct: 609 EEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFC-RMDVAVLSYCVRCCP 667
Query: 626 --RCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHS 683
+ LR I + EKK K SL G R+ S T +
Sbjct: 668 AGQALRLISCRLVAAQEKK--KKSL------GKRLQASLGGGSSSQGTTK---------- 709
Query: 684 NLDKSAMNILHHELRHPNCKLQKLLLKFITFPDG-CQDISTSLIHNKNLMHLDLKGSDIG 742
L S ++ L + P C L L L PD C+D+S +L L L L + +
Sbjct: 710 QLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLS 769
Query: 743 DNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDG 802
+ G++ L E L P+C++QT+R++ + + L +S +L L+LS L
Sbjct: 770 EAGLRMLSEGLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPM 828
Query: 803 VQLLCEALRHPKCYLERLSLESCGLTEAGCEYL 835
V LC L+H C L+ LSL S L+E + L
Sbjct: 829 VTYLCAVLQHQGCGLQTLSLASVELSEQSLQEL 861
Score = 73.2 bits (178), Expect = 1e-12
Identities = 51/154 (33%), Positives = 75/154 (48%), Gaps = 1/154 (0%)
Query: 806 LCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSD 865
L +A+ P C+L L+L C L +A C LS AL + LT L L N L + G++++S+
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 866 ALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFR 925
L QC +++ V + +YL L + +LT LDL L V LC V +
Sbjct: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 926 HPSCNLQDLELMGCVLTNACCLDLASVILNNPNL 959
H C LQ L L L+ +L +V P+L
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDL 871
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/149 (29%), Positives = 71/149 (47%), Gaps = 1/149 (0%)
Query: 927 PSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNC 986
P C+L L L C L +A C DL+ + P L L L +N L + G+++L + L +P C
Sbjct: 726 PLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWPQC 785
Query: 987 NIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQ 1046
+Q + ++ Q L L + L ++L+ L + L VL+ C LQ
Sbjct: 786 RVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCGLQ 844
Query: 1047 VLGLCKEAFDEEAQKLLEAVGVSNPHLII 1075
L L E++ + L+AV + P L+I
Sbjct: 845 TLSLASVELSEQSLQELQAVKRAKPDLVI 873
Score = 57.8 bits (138), Expect = 6e-08
Identities = 43/144 (29%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Query: 749 LCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCE 808
L +A+ P C L +L L C L C ++S AL + +L L L N L + G+++L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 809 ALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQ 868
L P+C ++ + ++ + G +YL L + LT L L+ L V + LQ
Sbjct: 779 GLAWPQCRVQTVRVQLPD-PQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 869 HAQCTLKSLVLRRCHFTSLSSEYL 892
H C L++L L + S + L
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQEL 861
Score = 45.1 bits (105), Expect = 4e-04
Identities = 24/72 (33%), Positives = 37/72 (51%)
Query: 977 LCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYK 1036
L A+ P C++ L L +C L C+DLS AL L ++ L N L G+ L +
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 1037 VLKSPKCKLQVL 1048
L P+C++Q +
Sbjct: 779 GLAWPQCRVQTV 790
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 251 bits (640), Expect = 3e-66
Identities = 186/591 (31%), Positives = 284/591 (48%), Gaps = 29/591 (4%)
Query: 11 PDFGLLLYLEELNKEELNTFKLFLKETMEPEHGLTPW--NEVKKARREDLANLMKKYYPG 68
P LL L +L + + K +L++ M G P E++ DLA L+ Y
Sbjct: 9 PREALLWALSDLEENDFKKLKFYLRD-MTLSEGQPPLARGELEGLIPVDLAELLISKYGE 67
Query: 69 EKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGTEYRN 128
++A V LK MNL +L ++ + + + + E E QEA +
Sbjct: 68 KEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLE--EWQEAGVN------G 119
Query: 129 RIKEKFCITWDKKSLAGKPEDFHHGIAEKDRK--LLEHLFDVDVKTGAQPQIVVLQGAAG 186
R + + K + PE E++ + +E LFD K P +VVLQG+AG
Sbjct: 120 RYNQVLLVA---KPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAG 176
Query: 187 VGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEE 246
GKTTL RK +LDWA G+LY RF YVFY++ +E+ L E QL+ + P+ E
Sbjct: 177 TGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTE 236
Query: 247 IMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVT 306
I+ QP LLFI+D FDEL FEE P L+ L+R+ LP SLL+T
Sbjct: 237 ILRQPERLLFILDGFDELQRPFEEK-----LKKRGLSPKESLLHLLIRRHTLPTCSLLIT 291
Query: 307 TRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMC 366
TR + L+ LLK +V +LG SE+ R Y +F D++ A + F ++ N++L+ C
Sbjct: 292 TRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKAC 351
Query: 367 QVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTP-VDGGSPSLPNQAQLR 425
QVP +CW C+ L+ QME+G V T + +T +F Y+S+ P DGG L LR
Sbjct: 352 QVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLR 411
Query: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
LC +AA+GI ++F LR+ L +++F+ SN Q + Y F H+ Q+
Sbjct: 412 SLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQD 471
Query: 486 FFAAMFYMLK-GSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQL 544
FF AM Y++K G S + + L + + + LT FL + +D L
Sbjct: 472 FFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQ--FLLDISKKDSFSNL 529
Query: 545 ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFI 595
E F ++S + L E + + ++ + +L LYE + K +
Sbjct: 530 ELKFCFRISPCLAQDLKHFKEQMESMKHNRT----WDLEFSLYEAKIKNLV 576
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 234 bits (596), Expect = 4e-61
Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
+D+ S L N L EL+L + L ++ + L+ P+CK+QKL L+ GC +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
S++L L L L + +GD G++ LCE L P+C+L+ L+LE C+L+ C +++
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
L L +S N++ + GV++LC+ L+ C LE L LESCG+T C L + S
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
L L L N LGD G+ + L H L++L + C T+ L L +S
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
L L L N L D G +LLC+ P C L+ L + C T ACC +SV+ N L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
L + NN L+D GV+ LC L P ++ L L C ++ C L++ L+ N L +++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Query: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
+ N LG GI++L + ++ P C L+ L L + EE + L+A+ P L
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
Score = 213 bits (543), Expect = 6e-55
Identities = 126/356 (35%), Positives = 195/356 (54%)
Query: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
C+DIS++L N L L+L+ +++GD GV + + L+ P CK+Q L L++C LT C
Sbjct: 45 CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
Query: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
+S+ L +L L+LS N L D G+QLLCE L P+C LE+L LE C L+ A CE L+
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
L + L +++N + + GV+++ L+ + C L++L L C TS + L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
SL L LGSN L D G+ LC HPS L+ L + C +T C DL V+
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 958 NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
+L+ L L N+L D+G ++LC+ L P C ++ L ++ C T+ CC SS L N+ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
++ ++ N L G+ +L + L P L+VL L + + L A ++N L
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Score = 187 bits (475), Expect = 5e-47
Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
++ LD++ ++ D L L+ + Q +RL+ C LT C +IS+AL + +L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
LNL +N L D GV + + L+ P C +++LSL++C LT AGC LS L + L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
L+DN+LGD G++L+ + L QC L+ L L C ++ S E L++ L L + +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
N + + GV++LC + C L+ L+L C +T+ C DL ++ + +LR L LG+N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
D G+ LC L +P+ ++ L + CG+T+ C DL L + L +++L N LG E
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 1030 GIVKLYKVLKSPKCKLQVL 1048
G L + L P C+L+ L
Sbjct: 300 GARLLCETLLEPGCQLESL 318
Score = 107 bits (268), Expect = 5e-23
Identities = 59/169 (34%), Positives = 92/169 (54%)
Query: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
C T + +S++L N +L L+L SN L D GV + + PSC +Q L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
T A C L+S + P L+ L L +N L D G+++LC+ L P C +++L LEYC L++
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
C+ L+S L ++ ++ N + G+ L + LK C+L+ L L
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 80.1 bits (196), Expect = 1e-14
Identities = 47/119 (39%), Positives = 68/119 (57%)
Query: 932 QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991
Q + L C LT A C D++S + NP L L+L +N+L D GV + L+ P+C IQ+L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 992 GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
L+ C LT C LSS L L +++L+ N LG G+ L + L P+C+L+ L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 234 bits (596), Expect = 4e-61
Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
+D+ S L N L EL+L + L ++ + L+ P+CK+QKL L+ GC +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
S++L L L L + +GD G++ LCE L P+C+L+ L+LE C+L+ C +++
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
L L +S N++ + GV++LC+ L+ C LE L LESCG+T C L + S
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
L L L N LGD G+ + L H L++L + C T+ L L +S
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
L L L N L D G +LLC+ P C L+ L + C T ACC +SV+ N L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
L + NN L+D GV+ LC L P ++ L L C ++ C L++ L+ N L +++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Query: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
+ N LG GI++L + ++ P C L+ L L + EE + L+A+ P L
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
Score = 213 bits (543), Expect = 6e-55
Identities = 126/356 (35%), Positives = 195/356 (54%)
Query: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
C+DIS++L N L L+L+ +++GD GV + + L+ P CK+Q L L++C LT C
Sbjct: 45 CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
Query: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
+S+ L +L L+LS N L D G+QLLCE L P+C LE+L LE C L+ A CE L+
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
L + L +++N + + GV+++ L+ + C L++L L C TS + L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
SL L LGSN L D G+ LC HPS L+ L + C +T C DL V+
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 958 NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
+L+ L L N+L D+G ++LC+ L P C ++ L ++ C T+ CC SS L N+ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
++ ++ N L G+ +L + L P L+VL L + + L A ++N L
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Score = 187 bits (475), Expect = 5e-47
Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
++ LD++ ++ D L L+ + Q +RL+ C LT C +IS+AL + +L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
LNL +N L D GV + + L+ P C +++LSL++C LT AGC LS L + L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
L+DN+LGD G++L+ + L QC L+ L L C ++ S E L++ L L + +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
N + + GV++LC + C L+ L+L C +T+ C DL ++ + +LR L LG+N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
D G+ LC L +P+ ++ L + CG+T+ C DL L + L +++L N LG E
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 1030 GIVKLYKVLKSPKCKLQVL 1048
G L + L P C+L+ L
Sbjct: 300 GARLLCETLLEPGCQLESL 318
Score = 107 bits (268), Expect = 5e-23
Identities = 59/169 (34%), Positives = 92/169 (54%)
Query: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
C T + +S++L N +L L+L SN L D GV + + PSC +Q L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
T A C L+S + P L+ L L +N L D G+++LC+ L P C +++L LEYC L++
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
C+ L+S L ++ ++ N + G+ L + LK C+L+ L L
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 80.1 bits (196), Expect = 1e-14
Identities = 47/119 (39%), Positives = 68/119 (57%)
Query: 932 QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991
Q + L C LT A C D++S + NP L L+L +N+L D GV + L+ P+C IQ+L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 992 GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
L+ C LT C LSS L L +++L+ N LG G+ L + L P+C+L+ L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 234 bits (596), Expect = 4e-61
Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
+D+ S L N L EL+L + L ++ + L+ P+CK+QKL L+ GC +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
S++L L L L + +GD G++ LCE L P+C+L+ L+LE C+L+ C +++
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
L L +S N++ + GV++LC+ L+ C LE L LESCG+T C L + S
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
L L L N LGD G+ + L H L++L + C T+ L L +S
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
L L L N L D G +LLC+ P C L+ L + C T ACC +SV+ N L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
L + NN L+D GV+ LC L P ++ L L C ++ C L++ L+ N L +++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Query: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
+ N LG GI++L + ++ P C L+ L L + EE + L+A+ P L
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
Score = 213 bits (543), Expect = 6e-55
Identities = 126/356 (35%), Positives = 195/356 (54%)
Query: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
C+DIS++L N L L+L+ +++GD GV + + L+ P CK+Q L L++C LT C
Sbjct: 45 CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
Query: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
+S+ L +L L+LS N L D G+QLLCE L P+C LE+L LE C L+ A CE L+
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
L + L +++N + + GV+++ L+ + C L++L L C TS + L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
SL L LGSN L D G+ LC HPS L+ L + C +T C DL V+
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 958 NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
+L+ L L N+L D+G ++LC+ L P C ++ L ++ C T+ CC SS L N+ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
++ ++ N L G+ +L + L P L+VL L + + L A ++N L
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Score = 187 bits (475), Expect = 5e-47
Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
++ LD++ ++ D L L+ + Q +RL+ C LT C +IS+AL + +L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
LNL +N L D GV + + L+ P C +++LSL++C LT AGC LS L + L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
L+DN+LGD G++L+ + L QC L+ L L C ++ S E L++ L L + +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
N + + GV++LC + C L+ L+L C +T+ C DL ++ + +LR L LG+N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
D G+ LC L +P+ ++ L + CG+T+ C DL L + L +++L N LG E
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 1030 GIVKLYKVLKSPKCKLQVL 1048
G L + L P C+L+ L
Sbjct: 300 GARLLCETLLEPGCQLESL 318
Score = 107 bits (268), Expect = 5e-23
Identities = 59/169 (34%), Positives = 92/169 (54%)
Query: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
C T + +S++L N +L L+L SN L D GV + + PSC +Q L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
T A C L+S + P L+ L L +N L D G+++LC+ L P C +++L LEYC L++
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
C+ L+S L ++ ++ N + G+ L + LK C+L+ L L
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 80.1 bits (196), Expect = 1e-14
Identities = 47/119 (39%), Positives = 68/119 (57%)
Query: 932 QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991
Q + L C LT A C D++S + NP L L+L +N+L D GV + L+ P+C IQ+L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 992 GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
L+ C LT C LSS L L +++L+ N LG G+ L + L P+C+L+ L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 234 bits (596), Expect = 4e-61
Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
+D+ S L N L EL+L + L ++ + L+ P+CK+QKL L+ GC +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
S++L L L L + +GD G++ LCE L P+C+L+ L+LE C+L+ C +++
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
L L +S N++ + GV++LC+ L+ C LE L LESCG+T C L + S
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
L L L N LGD G+ + L H L++L + C T+ L L +S
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
L L L N L D G +LLC+ P C L+ L + C T ACC +SV+ N L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
L + NN L+D GV+ LC L P ++ L L C ++ C L++ L+ N L +++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Query: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
+ N LG GI++L + ++ P C L+ L L + EE + L+A+ P L
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
Score = 213 bits (543), Expect = 6e-55
Identities = 126/356 (35%), Positives = 195/356 (54%)
Query: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
C+DIS++L N L L+L+ +++GD GV + + L+ P CK+Q L L++C LT C
Sbjct: 45 CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
Query: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
+S+ L +L L+LS N L D G+QLLCE L P+C LE+L LE C L+ A CE L+
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
L + L +++N + + GV+++ L+ + C L++L L C TS + L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
SL L LGSN L D G+ LC HPS L+ L + C +T C DL V+
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 958 NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
+L+ L L N+L D+G ++LC+ L P C ++ L ++ C T+ CC SS L N+ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
++ ++ N L G+ +L + L P L+VL L + + L A ++N L
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Score = 187 bits (475), Expect = 5e-47
Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
++ LD++ ++ D L L+ + Q +RL+ C LT C +IS+AL + +L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
LNL +N L D GV + + L+ P C +++LSL++C LT AGC LS L + L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
L+DN+LGD G++L+ + L QC L+ L L C ++ S E L++ L L + +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
N + + GV++LC + C L+ L+L C +T+ C DL ++ + +LR L LG+N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
D G+ LC L +P+ ++ L + CG+T+ C DL L + L +++L N LG E
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 1030 GIVKLYKVLKSPKCKLQVL 1048
G L + L P C+L+ L
Sbjct: 300 GARLLCETLLEPGCQLESL 318
Score = 107 bits (268), Expect = 5e-23
Identities = 59/169 (34%), Positives = 92/169 (54%)
Query: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
C T + +S++L N +L L+L SN L D GV + + PSC +Q L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
T A C L+S + P L+ L L +N L D G+++LC+ L P C +++L LEYC L++
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
C+ L+S L ++ ++ N + G+ L + LK C+L+ L L
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 80.1 bits (196), Expect = 1e-14
Identities = 47/119 (39%), Positives = 68/119 (57%)
Query: 932 QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991
Q + L C LT A C D++S + NP L L+L +N+L D GV + L+ P+C IQ+L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 992 GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
L+ C LT C LSS L L +++L+ N LG G+ L + L P+C+L+ L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 234 bits (596), Expect = 4e-61
Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
+D+ S L N L EL+L + L ++ + L+ P+CK+QKL L+ GC +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
S++L L L L + +GD G++ LCE L P+C+L+ L+LE C+L+ C +++
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
L L +S N++ + GV++LC+ L+ C LE L LESCG+T C L + S
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
L L L N LGD G+ + L H L++L + C T+ L L +S
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
L L L N L D G +LLC+ P C L+ L + C T ACC +SV+ N L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
L + NN L+D GV+ LC L P ++ L L C ++ C L++ L+ N L +++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Query: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
+ N LG GI++L + ++ P C L+ L L + EE + L+A+ P L
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
Score = 213 bits (543), Expect = 6e-55
Identities = 126/356 (35%), Positives = 195/356 (54%)
Query: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
C+DIS++L N L L+L+ +++GD GV + + L+ P CK+Q L L++C LT C
Sbjct: 45 CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
Query: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
+S+ L +L L+LS N L D G+QLLCE L P+C LE+L LE C L+ A CE L+
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
L + L +++N + + GV+++ L+ + C L++L L C TS + L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
SL L LGSN L D G+ LC HPS L+ L + C +T C DL V+
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 958 NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
+L+ L L N+L D+G ++LC+ L P C ++ L ++ C T+ CC SS L N+ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
++ ++ N L G+ +L + L P L+VL L + + L A ++N L
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Score = 187 bits (475), Expect = 5e-47
Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
++ LD++ ++ D L L+ + Q +RL+ C LT C +IS+AL + +L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
LNL +N L D GV + + L+ P C +++LSL++C LT AGC LS L + L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
L+DN+LGD G++L+ + L QC L+ L L C ++ S E L++ L L + +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
N + + GV++LC + C L+ L+L C +T+ C DL ++ + +LR L LG+N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
D G+ LC L +P+ ++ L + CG+T+ C DL L + L +++L N LG E
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 1030 GIVKLYKVLKSPKCKLQVL 1048
G L + L P C+L+ L
Sbjct: 300 GARLLCETLLEPGCQLESL 318
Score = 107 bits (268), Expect = 5e-23
Identities = 59/169 (34%), Positives = 92/169 (54%)
Query: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
C T + +S++L N +L L+L SN L D GV + + PSC +Q L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
T A C L+S + P L+ L L +N L D G+++LC+ L P C +++L LEYC L++
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
C+ L+S L ++ ++ N + G+ L + LK C+L+ L L
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 80.1 bits (196), Expect = 1e-14
Identities = 47/119 (39%), Positives = 68/119 (57%)
Query: 932 QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991
Q + L C LT A C D++S + NP L L+L +N+L D GV + L+ P+C IQ+L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 992 GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
L+ C LT C LSS L L +++L+ N LG G+ L + L P+C+L+ L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 234 bits (596), Expect = 4e-61
Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)
Query: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
+D+ S L N L EL+L + L ++ + L+ P+CK+QKL L+ GC +
Sbjct: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
Query: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
S++L L L L + +GD G++ LCE L P+C+L+ L+LE C+L+ C +++
Sbjct: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
Query: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
L L +S N++ + GV++LC+ L+ C LE L LESCG+T C L + S
Sbjct: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
Query: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
L L L N LGD G+ + L H L++L + C T+ L L +S
Sbjct: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
Query: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
L L L N L D G +LLC+ P C L+ L + C T ACC +SV+ N L
Sbjct: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
Query: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
L + NN L+D GV+ LC L P ++ L L C ++ C L++ L+ N L +++L
Sbjct: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
Query: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
+ N LG GI++L + ++ P C L+ L L + EE + L+A+ P L
Sbjct: 406 SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
Score = 213 bits (543), Expect = 6e-55
Identities = 126/356 (35%), Positives = 195/356 (54%)
Query: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
C+DIS++L N L L+L+ +++GD GV + + L+ P CK+Q L L++C LT C
Sbjct: 45 CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
Query: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
+S+ L +L L+LS N L D G+QLLCE L P+C LE+L LE C L+ A CE L+
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
L + L +++N + + GV+++ L+ + C L++L L C TS + L +
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
SL L LGSN L D G+ LC HPS L+ L + C +T C DL V+
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 958 NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
+L+ L L N+L D+G ++LC+ L P C ++ L ++ C T+ CC SS L N+ L+
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
++ ++ N L G+ +L + L P L+VL L + + L A ++N L
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
Score = 187 bits (475), Expect = 5e-47
Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)
Query: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
++ LD++ ++ D L L+ + Q +RL+ C LT C +IS+AL + +L
Sbjct: 4 DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
Query: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
LNL +N L D GV + + L+ P C +++LSL++C LT AGC LS L + L L
Sbjct: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
Query: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
L+DN+LGD G++L+ + L QC L+ L L C ++ S E L++ L L + +
Sbjct: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
Query: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
N + + GV++LC + C L+ L+L C +T+ C DL ++ + +LR L LG+N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
D G+ LC L +P+ ++ L + CG+T+ C DL L + L +++L N LG E
Sbjct: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
Query: 1030 GIVKLYKVLKSPKCKLQVL 1048
G L + L P C+L+ L
Sbjct: 300 GARLLCETLLEPGCQLESL 318
Score = 107 bits (268), Expect = 5e-23
Identities = 59/169 (34%), Positives = 92/169 (54%)
Query: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
C T + +S++L N +L L+L SN L D GV + + PSC +Q L L C L
Sbjct: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
Query: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
T A C L+S + P L+ L L +N L D G+++LC+ L P C +++L LEYC L++
Sbjct: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
Query: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
C+ L+S L ++ ++ N + G+ L + LK C+L+ L L
Sbjct: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
Score = 80.1 bits (196), Expect = 1e-14
Identities = 47/119 (39%), Positives = 68/119 (57%)
Query: 932 QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991
Q + L C LT A C D++S + NP L L+L +N+L D GV + L+ P+C IQ+L
Sbjct: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Query: 992 GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
L+ C LT C LSS L L +++L+ N LG G+ L + L P+C+L+ L L
Sbjct: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,326,454
Number of Sequences: 37866
Number of extensions: 1843496
Number of successful extensions: 5892
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 55
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 4884
Number of HSP's gapped (non-prelim): 364
length of query: 1093
length of database: 18,247,518
effective HSP length: 113
effective length of query: 980
effective length of database: 13,968,660
effective search space: 13689286800
effective search space used: 13689286800
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.