Search of human proteins with 28626517

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28626517 protein phosphatase 1 regulatory inhibitor subunit
16B [Homo sapiens]
         (567 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1...  1143   0.0  
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni...   474   e-134
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni...   198   1e-50
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit...   198   1e-50
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun...   189   4e-48
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit...   189   4e-48
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ...   188   1e-47
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]                   158   1e-38
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun...   142   1e-33
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       112   7e-25
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   112   7e-25
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        111   2e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   110   3e-24
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        103   4e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        103   4e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        103   4e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        103   4e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   102   1e-21
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        100   3e-21
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        100   3e-21
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   100   4e-21
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       100   5e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...    96   7e-20
gi|89363047 death-associated protein kinase 1 [Homo sapiens]           93   6e-19
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                     93   6e-19
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    91   2e-18
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...    91   3e-18
gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Hom...    89   1e-17
gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo ...    89   1e-17
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                   88   2e-17

>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
           [Homo sapiens]
          Length = 567

 Score = 1143 bits (2957), Expect = 0.0
 Identities = 567/567 (100%), Positives = 567/567 (100%)

Query: 1   MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGR 60
           MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGR
Sbjct: 1   MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGR 60

Query: 61  RKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLL 120
           RKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLL
Sbjct: 61  RKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLL 120

Query: 121 LSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTL 180
           LSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTL
Sbjct: 121 LSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTL 180

Query: 181 DVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG 240
           DVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG
Sbjct: 181 DVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG 240

Query: 241 YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
           YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID
Sbjct: 241 YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID 300

Query: 301 LCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRK 360
           LCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRK
Sbjct: 301 LCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRK 360

Query: 361 EYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGEL 420
           EYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGEL
Sbjct: 361 EYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGEL 420

Query: 421 DMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTL 480
           DMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTL
Sbjct: 421 DMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTL 480

Query: 481 LELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVT 540
           LELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVT
Sbjct: 481 LELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVT 540

Query: 541 SGDPPLLKFKAPIEEMEEKVHGCCRIS 567
           SGDPPLLKFKAPIEEMEEKVHGCCRIS
Sbjct: 541 SGDPPLLKFKAPIEEMEEKVHGCCRIS 567


>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
           16A [Homo sapiens]
          Length = 528

 Score =  474 bits (1220), Expect = e-134
 Identities = 270/567 (47%), Positives = 351/567 (61%), Gaps = 45/567 (7%)

Query: 1   MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKR---ST 57
           MA H++LL E+ ++ ++ T ERL+ AQKRRAQQ+K WAQ E++ Q +K   ER R   ++
Sbjct: 1   MAEHLELLAEMPMVGRMSTQERLKHAQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAAS 60

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
            G  K+V F  SV LLEA+ RND EEVR FL + VSPDL NEDGLTALHQCCID+F E+V
Sbjct: 61  QGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQCCIDDFREMV 120

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
           + LL  GAN+NA D+E WTPLHAAATCGH++LV++L+  GA+LLAVN+DGNMPYDLC+DE
Sbjct: 121 QQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDE 180

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
            TLD +ET MA +GITQ+ I   R  PE +M+ DI   + AG DL      GATLLH+A 
Sbjct: 181 QTLDCLETAMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDHGATLLHVAA 240

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
           ANG+  AA LLL+H   +  KD DGWEPLHAAA+WGQ+ + ELLV+HGA L+A++ MDE 
Sbjct: 241 ANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDET 300

Query: 298 PIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNL 357
           P+D+C +EE +  LLELKHKHD ++++Q R +S L RRTSSAGSRGKVVRR SL+ RT+L
Sbjct: 301 PLDVCGDEEVRAKLLELKHKHDALLRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDL 360

Query: 358 YRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPR 417
           YRK++  EAI+WQ+           N D    +T  E + P P  + P ++     ++  
Sbjct: 361 YRKQHAQEAIVWQQPPPTSPEPPEDNDD---RQTGAELRPPPPEEDNPEVVRPHNGRVG- 416

Query: 418 GELDMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSP 477
                PV +        Y   L            D S++Y      D+T P +   +++ 
Sbjct: 417 ---GSPVRH-------LYSKRL------------DRSVSY-QLSPLDSTTPHTLVHDKAH 453

Query: 478 QTLLELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYY 537
            TL +LKRQRAAAKL   P              ES    +  L G   +P    G     
Sbjct: 454 HTLADLKRQRAAAKLQRPP----------PEGPESPETAEPGLPGDTVTPQPDCGFR--- 500

Query: 538 TVTSGDPPLLKFKAPIEEMEEKVHGCC 564
               GDPPLLK  AP  E   +   CC
Sbjct: 501 --AGGDPPLLKLTAPAVEAPVERRPCC 525


>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform b [Homo sapiens]
          Length = 998

 Score =  198 bits (504), Expect = 1e-50
 Identities = 127/387 (32%), Positives = 197/387 (50%), Gaps = 17/387 (4%)

Query: 21  ERLRAAQKRRAQQLKKW--AQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLR 78
           +R  +A+ RRA+QL++W  +  EQ+   R R   R+  T     +V FE     L A   
Sbjct: 10  KRAESARMRRAEQLRRWRGSLTEQEPAER-RGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68

Query: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
            D +EVR  L      +  N DGLTALHQ CID   ++VK L+ + ANVN +DNE WTPL
Sbjct: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128

Query: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN 198
           HAAA+CG++N+ +  + +GA +  VNS+G +P DL E+    D++   +  QGI  E   
Sbjct: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLE--- 185

Query: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAAELLLDHGVRVDV 257
           + R   EQQM+ D    + +G+  D   A+ GAT LH+A A GY     LL+  G  ++V
Sbjct: 186 QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV 245

Query: 258 KDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHK 317
           +D+DGW PLHAAA WG  +   +L      +  R  + + P D+ +E    V  LEL  K
Sbjct: 246 QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEG--LVEHLELLQK 303

Query: 318 HDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQRSAAEDQ 377
              +++S+   ++ L     ++  +    +        N  +  YE E    Q    E++
Sbjct: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFK--------NKEKMLYEEETPKSQEMEEENK 355

Query: 378 RTSTYNGDIRETRTDQENKDPNPRLEK 404
            +S+ + +  E   +    +     +K
Sbjct: 356 ESSSSSSEEEEGEDEASESETEKEADK 382


>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform a [Homo sapiens]
          Length = 982

 Score =  198 bits (504), Expect = 1e-50
 Identities = 127/387 (32%), Positives = 197/387 (50%), Gaps = 17/387 (4%)

Query: 21  ERLRAAQKRRAQQLKKW--AQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLR 78
           +R  +A+ RRA+QL++W  +  EQ+   R R   R+  T     +V FE     L A   
Sbjct: 10  KRAESARMRRAEQLRRWRGSLTEQEPAER-RGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68

Query: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
            D +EVR  L      +  N DGLTALHQ CID   ++VK L+ + ANVN +DNE WTPL
Sbjct: 69  GDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPL 128

Query: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN 198
           HAAA+CG++N+ +  + +GA +  VNS+G +P DL E+    D++   +  QGI  E   
Sbjct: 129 HAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLLEQVKKQGIDLE--- 185

Query: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAAELLLDHGVRVDV 257
           + R   EQQM+ D    + +G+  D   A+ GAT LH+A A GY     LL+  G  ++V
Sbjct: 186 QSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNV 245

Query: 258 KDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHK 317
           +D+DGW PLHAAA WG  +   +L      +  R  + + P D+ +E    V  LEL  K
Sbjct: 246 QDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADEG--LVEHLELLQK 303

Query: 318 HDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQRSAAEDQ 377
              +++S+   ++ L     ++  +    +        N  +  YE E    Q    E++
Sbjct: 304 KQNVLRSEKETRNKLIESDLNSKIQSGFFK--------NKEKMLYEEETPKSQEMEEENK 355

Query: 378 RTSTYNGDIRETRTDQENKDPNPRLEK 404
            +S+ + +  E   +    +     +K
Sbjct: 356 ESSSSSSEEEEGEDEASESETEKEADK 382


>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score =  189 bits (481), Expect = 4e-48
 Identities = 109/318 (34%), Positives = 174/318 (54%), Gaps = 13/318 (4%)

Query: 22  RLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDA 81
           ++  A+++R +QLK+W   E DL+    K ++         KV F+     L A    D 
Sbjct: 2   KMADAKQKRNEQLKRWIGSETDLEPPVVKRQKT--------KVKFDDGAVFLAACSSGDT 53

Query: 82  EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
           +EV   L      +  N DGLTALHQ CID+  ++VK L+ +GAN+N  DNE W PLHAA
Sbjct: 54  DEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAA 113

Query: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMR 201
           A+CG++++ + L+  GA + AVNS+G+ P D+ E+E   ++++  +  QG+    I   R
Sbjct: 114 ASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV---DIEAAR 170

Query: 202 VAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAAELLLDHGVRVDVKDW 260
              E+ M+ D    + +G   D   A+ G T LH+A A GY    +LL+  G  V++KD+
Sbjct: 171 KEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDY 230

Query: 261 DGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDV 320
           DGW PLHAAA WG+ +   +LV +   +     + +   D+  +E+    L EL+ K ++
Sbjct: 231 DGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLEELQKKQNL 289

Query: 321 IMKSQLRHKSSLSRRTSS 338
           +   +   KS L   T++
Sbjct: 290 LHSEKRDKKSPLIESTAN 307


>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score =  189 bits (481), Expect = 4e-48
 Identities = 109/318 (34%), Positives = 174/318 (54%), Gaps = 13/318 (4%)

Query: 22  RLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDA 81
           ++  A+++R +QLK+W   E DL+    K ++         KV F+     L A    D 
Sbjct: 2   KMADAKQKRNEQLKRWIGSETDLEPPVVKRQKT--------KVKFDDGAVFLAACSSGDT 53

Query: 82  EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
           +EV   L      +  N DGLTALHQ CID+  ++VK L+ +GAN+N  DNE W PLHAA
Sbjct: 54  DEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAA 113

Query: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMR 201
           A+CG++++ + L+  GA + AVNS+G+ P D+ E+E   ++++  +  QG+    I   R
Sbjct: 114 ASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGV---DIEAAR 170

Query: 202 VAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAAELLLDHGVRVDVKDW 260
              E+ M+ D    + +G   D   A+ G T LH+A A GY    +LL+  G  V++KD+
Sbjct: 171 KEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDY 230

Query: 261 DGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDV 320
           DGW PLHAAA WG+ +   +LV +   +     + +   D+  +E+    L EL+ K ++
Sbjct: 231 DGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLEELQKKQNL 289

Query: 321 IMKSQLRHKSSLSRRTSS 338
           +   +   KS L   T++
Sbjct: 290 LHSEKRDKKSPLIESTAN 307


>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
           sapiens]
          Length = 782

 Score =  188 bits (477), Expect = 1e-47
 Identities = 130/415 (31%), Positives = 198/415 (47%), Gaps = 43/415 (10%)

Query: 25  AAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKK-VSFEASVALLEASLRNDAEE 83
           AA++RR +QL++W            +   +   G RR + V FE +   L A    D +E
Sbjct: 17  AARERRREQLRQWGA----------RAGAEPGPGERRARTVRFERAAEFLAACAGGDLDE 66

Query: 84  VRYFLK----------NKVSP-------DLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
            R  L+          +  +P       D  N DG++ALHQ CID   E+V+ L+  GA 
Sbjct: 67  ARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGAT 126

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETC 186
           VN  DNE WTPLH AA+CG++++ + L+ +GA++ AVNSDG++P DL E +    +++  
Sbjct: 127 VNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAE 186

Query: 187 MAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAA 245
           +A +G+  E       A E+ ++ D  C +  G   +    + GA+ LH+A A GY+   
Sbjct: 187 IARRGVDVEAAKR---AEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVM 243

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE 305
            LLL  G   +++D DGW PLHAAA WG      LL  HG  + + T   + P DL +EE
Sbjct: 244 RLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEE 303

Query: 306 EFKVLLLELKHKHDVIMKSQLRHKS--------SLSRRTSSAGSRGKVVRRASLSDRTNL 357
               LL EL  K + +   +   +S        S S+   S+  R     + SL D +  
Sbjct: 304 VLS-LLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKE 362

Query: 358 YRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFP 412
            R    G   +      E+  T     + R    +  +  P+P  + PV L E P
Sbjct: 363 RRPGGAGGPPIQDEDEGEEGPTEPPPAEPR--TLNGVSSPPHPSPKSPVQLEEAP 415


>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
          Length = 1858

 Score =  158 bits (400), Expect = 1e-38
 Identities = 93/315 (29%), Positives = 166/315 (52%), Gaps = 3/315 (0%)

Query: 13  LLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVAL 72
           LLE +P  +R R  ++ R +Q+K  A YE++   +K++   KR    +  KV F  +  L
Sbjct: 7   LLESLPLGQRQRLVKRMRCEQIK--AYYEREKAFQKQEGFLKRLKHAKNPKVHFNLTDML 64

Query: 73  LEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDN 132
            +A + ++ +EV   LK    P      G + LH C   +   I ++L+  G NVN +D 
Sbjct: 65  QDAIIHHNDKEVLRLLKEGADPHTLVSSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDE 124

Query: 133 ELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC-EDEPTLDVIETCMAYQG 191
           + WTP+H A  C + ++V +LV  GA++L  + +GN+P D   E   +  ++ T +   G
Sbjct: 125 DFWTPMHIACACDNPDIVLLLVLAGANVLLQDVNGNIPLDYAVEGTESSSILLTYLDENG 184

Query: 192 ITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDH 251
           +    + +M++     M+ D+   +++G +++  + +G TLLH+A A+GY     L+L+H
Sbjct: 185 VDLTSLRQMKLQRPMSMLTDVKHFLSSGGNVNEKNDEGVTLLHMACASGYKEVVSLILEH 244

Query: 252 GVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLL 311
           G  +++ D   W PLH AA +GQ  + +LL+ H A+       +E   D+   E  + +L
Sbjct: 245 GGDLNIVDDQYWTPLHLAAKYGQTNLVKLLLMHQANPHLVNCNEEKASDIAASEFIEEML 304

Query: 312 LELKHKHDVIMKSQL 326
           L+ +   +  MK  L
Sbjct: 305 LKAEIAWEEKMKEPL 319


>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform b [Homo sapiens]
          Length = 943

 Score =  142 bits (357), Expect = 1e-33
 Identities = 78/224 (34%), Positives = 128/224 (57%), Gaps = 5/224 (2%)

Query: 116 IVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCE 175
           +VK L+ +GAN+N  DNE W PLHAAA+CG++++ + L+  GA + AVNS+G+ P D+ E
Sbjct: 1   MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60

Query: 176 DEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLH 234
           +E   ++++  +  QG+    I   R   E+ M+ D    + +G   D   A+ G T LH
Sbjct: 61  EEAMEELLQNEVNRQGV---DIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALH 117

Query: 235 IAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSM 294
           +A A GY    +LL+  G  V++KD+DGW PLHAAA WG+ +   +LV +   +     +
Sbjct: 118 VAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKV 177

Query: 295 DEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSS 338
            +   D+  +E+    L EL+ K +++   +   KS L   T++
Sbjct: 178 GQTAFDVA-DEDILGYLEELQKKQNLLHSEKRDKKSPLIESTAN 220



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 36/94 (38%), Positives = 49/94 (52%), Gaps = 1/94 (1%)

Query: 99  EDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGA 158
           + G TALH      + E++KLL+  G +VN KD + WTPLHAAA  G     +ILV    
Sbjct: 110 KSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLC 169

Query: 159 DLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI 192
           D+  VN  G   +D+  DE  L  +E     Q +
Sbjct: 170 DMEMVNKVGQTAFDVA-DEDILGYLEELQKKQNL 202


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  112 bits (281), Expect = 7e-25
 Identities = 88/334 (26%), Positives = 151/334 (45%), Gaps = 37/334 (11%)

Query: 31  AQQLKKWAQYE-QDLQHRKRKHE--RKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYF 87
           A+QLKK    E Q LQ +K K E  RKR    R +K   +A+ + L A+   + ++    
Sbjct: 5   AKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDH 64

Query: 88  LKNKVSPDLCNEDGL---------------------------------TALHQCCIDNFE 114
           L+N V  + CN++GL                                 TALH   +   +
Sbjct: 65  LRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQD 124

Query: 115 EIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC 174
           E+V+ L+++GANVNA+  + +TPL+ AA   H+ +VK L++ GA+      DG  P  + 
Sbjct: 125 EVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184

Query: 175 EDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLH 234
             +   +V+   + Y    + ++  + +A           ++    + D +   G T LH
Sbjct: 185 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 244

Query: 235 IAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSM 294
           IA     L  A+LLL+ G  V+    +G  PLH A+  G + M  LL+  GA +  +T  
Sbjct: 245 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 304

Query: 295 DEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRH 328
           +  P+  C      V + E+   H   ++++ ++
Sbjct: 305 ELTPLH-CAARNGHVRISEILLDHGAPIQAKTKN 337



 Score =  100 bits (250), Expect = 3e-21
 Identities = 86/286 (30%), Positives = 129/286 (45%), Gaps = 25/286 (8%)

Query: 57  TGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEI 116
           TG     V+      L  AS       V+  L+   SP++ N    T LH        E+
Sbjct: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 485

Query: 117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCED 176
            K LL + A VNAK  +  TPLH AA  GH N+VK+L++  A+     + G+ P  +   
Sbjct: 486 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 545

Query: 177 EPTLDVI---------ETCMAYQGIT----QEKINEMRVAPEQQMIADIHCMIAAGQDLD 223
           E  ++ +         + CM  +G T      K  ++RVA E  +  D H   AAG++  
Sbjct: 546 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA-ELLLERDAH-PNAAGKN-- 601

Query: 224 WIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVS 283
                G T LH+A  +  L   +LLL  G       W+G+ PLH AA   Q+++A  L+ 
Sbjct: 602 -----GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656

Query: 284 HGASLSARTSMDEMPIDLCEEE---EFKVLLLELKHKHDVIMKSQL 326
           +G S +A +     P+ L  +E   E   LLL  +   ++  KS L
Sbjct: 657 YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 702



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/229 (23%), Positives = 107/229 (46%), Gaps = 4/229 (1%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+     E V   L+ + S     + G T LH         + +LLL   A+ NA     
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
            TPLH A    ++++VK+L+  G    +   +G  P  +   +  ++V  + + Y G   
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662

Query: 195 EK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLD 250
            +    +  + +A ++     +  +++   + +  +  G T LH+    G++  A++L+ 
Sbjct: 663 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722

Query: 251 HGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           HGV VD     G+ PLH A+ +G +++ + L+ H A ++A+T +   P+
Sbjct: 723 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 771



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 59/220 (26%), Positives = 101/220 (45%), Gaps = 4/220 (1%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L+    P+   ++GLT LH     N  +IVKLLL  G + ++     +TPLH AA    +
Sbjct: 589 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 648

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI----TQEKINEMRVA 203
            + + L+QYG    A +  G  P  L   E   +++   ++ Q       +  +  + + 
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708

Query: 204 PEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGW 263
            ++  +     +I  G  +D     G T LH+A   G ++  + LL H   V+ K   G+
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768

Query: 264 EPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCE 303
            PLH AA  G   +  LL+ +GAS +  +S    P+ + +
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 62/234 (26%), Positives = 106/234 (45%), Gaps = 14/234 (5%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS R +   VR  L      +   +D LT LH    +    I ++LL HGA + AK    
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL---CEDEPTLDVI------ET 185
            +P+H AA   H++ V++L+QY A++  +  D   P  +   C       V+        
Sbjct: 339 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 398

Query: 186 CMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
             A  G T      + +A ++  +  +  ++  G  +D +   G T LH+A   G+L   
Sbjct: 399 SRALNGFT-----PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           + LL  G   +V +     PLH AA  G  ++A+ L+ + A ++A+   D+ P+
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 62/250 (24%), Positives = 113/250 (45%), Gaps = 5/250 (2%)

Query: 73  LEASLRNDAEEVRYFLKNKVSP-DLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + RN    +   L +  +P     ++GL+ +H     +  + V+LLL + A ++   
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 368

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE----TCM 187
            +  TPLH AA CGH  + K+L+  GA   +   +G  P  +   +  + V+E    T  
Sbjct: 369 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 428

Query: 188 AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
           +   +T+  +  + VA     +  +  ++  G   +  + +  T LH+A   G+   A+ 
Sbjct: 429 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 488

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEF 307
           LL +  +V+ K  D   PLH AA  G   M +LL+ + A+ +  T+    P+ +   E  
Sbjct: 489 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548

Query: 308 KVLLLELKHK 317
              +L L  K
Sbjct: 549 VETVLALLEK 558



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 42/147 (28%), Positives = 67/147 (45%), Gaps = 1/147 (0%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     S +    L  A+    AE V   L  + + +L N+ GLT LH    +    + 
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            +L+ HG  V+A     +TPLH A+  G+I LVK L+Q+ AD+ A    G  P      +
Sbjct: 718 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 777

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAP 204
              D++ T +   G +  +++     P
Sbjct: 778 GHTDIV-TLLLKNGASPNEVSSDGTTP 803



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 4/195 (2%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     ++     L  A+ +N  E  R  L+   S +  +  G+T LH    +   E+V
Sbjct: 625 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 684

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            LLLS  AN N  +    TPLH  A  GH+ +  +L+++G  + A    G  P  +    
Sbjct: 685 ALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 744

Query: 178 PTLDVIETCMAYQGITQEK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
             + +++  + +Q     K     + +  A +Q     +  ++  G   + + + G T L
Sbjct: 745 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804

Query: 234 HIAGANGYLRAAELL 248
            IA   GY+   ++L
Sbjct: 805 AIAKRLGYISVTDVL 819


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  112 bits (281), Expect = 7e-25
 Identities = 77/241 (31%), Positives = 118/241 (48%), Gaps = 25/241 (10%)

Query: 55  RSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFE 114
           R T GR+       S  L  A+     + V Y L+N  +    ++ GL  LH  C     
Sbjct: 52  RDTAGRK-------STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHA 104

Query: 115 EIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC 174
           E+V LLL HGA+ NA+DN  +TPLH AA  G I++  +L+Q+GA+    N+DG    DL 
Sbjct: 105 EVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164

Query: 175 EDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIA-----DIHCMIAAGQDLDWIDAQG 229
           +        +  +  +    E +   R   E++M+A     +++C  +        D + 
Sbjct: 165 DPS-----AKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHAS--------DGRK 211

Query: 230 ATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLS 289
           +T LH+A     ++  +LLL HG  V  KD     PLH A  +G  ++ ELLV HGA ++
Sbjct: 212 STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN 271

Query: 290 A 290
           A
Sbjct: 272 A 272



 Score =  112 bits (279), Expect = 1e-24
 Identities = 78/250 (31%), Positives = 123/250 (49%), Gaps = 13/250 (5%)

Query: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
           N    V Y L++       ++ GL  LH  C     E+ +LL+ HGA VN  D   +TPL
Sbjct: 537 NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPL 596

Query: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN 198
           H AA  G   + K+L+Q+GAD    N DGN P DL +D  T D+ +       +      
Sbjct: 597 HEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT-DIQDLLRGDAALLD---- 651

Query: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQG--ATLLHIAGANGYLRAAELLLDHGVRVD 256
               A ++  +A +   +++  +++  D QG  +T LH+A     L  AE LL HG  V+
Sbjct: 652 ----AAKKGCLARVK-KLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 257 VKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI-DLCEEEEFKVLLLELK 315
            +D  G  PLH AA +G + +A LL+ + A ++A       P+ +  ++   ++  L L 
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766

Query: 316 HKHDVIMKSQ 325
           H  D  +K+Q
Sbjct: 767 HGADPTLKNQ 776



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 63/225 (28%), Positives = 105/225 (46%), Gaps = 3/225 (1%)

Query: 102 LTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLL 161
           LT LH        ++V++++ H A VNA DN   T LH AA CGH+   ++L+ YG D  
Sbjct: 401 LTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPN 460

Query: 162 AVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQD 221
            ++  G     +  +     + E           ++ E   A + + +  + C + +   
Sbjct: 461 IISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKL-CTVQSVNC 519

Query: 222 LDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELL 281
            D I+ + +T LH A     +   E LL HG  V  KD  G  PLH A  +G  ++AELL
Sbjct: 520 RD-IEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELL 578

Query: 282 VSHGASLSARTSMDEMPI-DLCEEEEFKVLLLELKHKHDVIMKSQ 325
           V HGA ++        P+ +   + ++++  L L+H  D   K++
Sbjct: 579 VKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNR 623



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 61/239 (25%), Positives = 102/239 (42%), Gaps = 36/239 (15%)

Query: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
           N  + V+  L++       ++  L  LH  C     E+ +LL+ HGA VNA D   +TPL
Sbjct: 222 NRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPL 281

Query: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY--------Q 190
           H AA+   + +  +L+ YGAD   +N       DL    PT  + E  +AY        Q
Sbjct: 282 HEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA---PTPQLKER-LAYEFKGHSLLQ 337

Query: 191 GITQEKINEMRVAPEQQMI---------ADIHCMIAA---------------GQDLDWID 226
              +  +  ++     +M+           +HC  A+               G +++   
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397

Query: 227 AQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHG 285
            +  T LH+A    +    E+++ H  +V+  D  G   LH AA+ G +Q   LL+S+G
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYG 456



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 62/248 (25%), Positives = 109/248 (43%), Gaps = 14/248 (5%)

Query: 62  KKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLL 121
           K   F   + +      ND  EV   +K++   +  +  G T+LH+       +  +LLL
Sbjct: 396 KTKEFLTPLHVASEKAHNDVVEV--VVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLL 453

Query: 122 SHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLD 181
           S+G + N    + +T L      G+ N V+ L+Q G  L   NS+ +           ++
Sbjct: 454 SYGCDPNIISLQGFTALQ----MGNEN-VQQLLQEGISL--GNSEADRQLLEAAKAGDVE 506

Query: 182 VIETCMAYQGITQEKI-----NEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIA 236
            ++     Q +    I       +  A     ++ +  ++  G D+   D  G   LH A
Sbjct: 507 TVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNA 566

Query: 237 GANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDE 296
            + G+   AELL+ HG  V+V D   + PLH AA  G+ ++ +LL+ HGA  + +     
Sbjct: 567 CSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGN 626

Query: 297 MPIDLCEE 304
            P+DL ++
Sbjct: 627 TPLDLVKD 634



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 67/255 (26%), Positives = 114/255 (44%), Gaps = 31/255 (12%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGL--TALHQCCIDNFEEIVKLLLSHGANVNA 129
           LLE S R+  EE    L   ++ +    DG   T LH     N  +IV+LLL HGA+V+A
Sbjct: 181 LLE-SARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239

Query: 130 KDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY 189
           KD     PLH A + GH  + ++LV++GA + A++     P      +  ++V    ++Y
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299

Query: 190 QG----ITQEKINEMRVAPEQQMIADI------HCMIAAGQDLDWIDAQ----------- 228
                 +     + + +AP  Q+   +      H ++ A ++ D    +           
Sbjct: 300 GADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFK 359

Query: 229 ----GATLLHIAGANGY---LRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELL 281
                 T LH A A+ Y    +  ELLL  G  ++ K  +   PLH A+      + E++
Sbjct: 360 HPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVV 419

Query: 282 VSHGASLSARTSMDE 296
           V H A ++A  ++ +
Sbjct: 420 VKHEAKVNALDNLGQ 434



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 40/133 (30%), Positives = 59/133 (44%), Gaps = 7/133 (5%)

Query: 55  RSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFE 114
           R T GR        S  L  A+  N+ E   Y L++    +  ++ GL  LH        
Sbjct: 673 RDTQGRH-------STPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHV 725

Query: 115 EIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC 174
           ++  LL+ + A VNA D   +TPLH AA  G   L  +L+ +GAD    N +G  P DL 
Sbjct: 726 DVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLV 785

Query: 175 EDEPTLDVIETCM 187
             +    ++   M
Sbjct: 786 SADDVSALLTAAM 798



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/113 (28%), Positives = 55/113 (48%), Gaps = 2/113 (1%)

Query: 212 IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAF 271
           +  ++  G ++   D  G   LH A + G+     LLL HG   + +D   + PLH AA 
Sbjct: 74  VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAI 133

Query: 272 WGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKS 324
            G++ +  +L+ HGA  + R +     +DL +     VL  E  +K D +++S
Sbjct: 134 KGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGE--YKKDELLES 184



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 28/88 (31%), Positives = 45/88 (51%), Gaps = 1/88 (1%)

Query: 230 ATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLS 289
           +T LH A   G     E LL +G  V  +D  G  PLH A  +G  ++  LL+ HGA  +
Sbjct: 59  STPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPN 118

Query: 290 ARTSMDEMPI-DLCEEEEFKVLLLELKH 316
           AR + +  P+ +   + +  V ++ L+H
Sbjct: 119 ARDNWNYTPLHEAAIKGKIDVCIVLLQH 146



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 58/246 (23%), Positives = 101/246 (41%), Gaps = 29/246 (11%)

Query: 99  EDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDN--ELWTPLHAAATCGHINLVKILVQY 156
           E     L + C +   E VK L++    VN++D      TPLH AA  G  ++V+ L+Q 
Sbjct: 22  EPAARELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQN 80

Query: 157 GADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN----EMRVAPEQQMIADI 212
           GA++ A +  G +P          +V+   + +      + N     +  A  +  I   
Sbjct: 81  GANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVC 140

Query: 213 HCMIAAGQDLDWIDAQGATLLHIAGANG------------YLRAAE---------LLLDH 251
             ++  G +    +  G T L +A  +              L +A          LL   
Sbjct: 141 IVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPL 200

Query: 252 GVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI-DLCEEEEFKVL 310
            V     D     PLH AA + ++++ +LL+ HGA + A+   D +P+ + C    ++V 
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260

Query: 311 LLELKH 316
            L +KH
Sbjct: 261 ELLVKH 266


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  111 bits (278), Expect = 2e-24
 Identities = 87/280 (31%), Positives = 137/280 (48%), Gaps = 13/280 (4%)

Query: 31  AQQLKKWAQYE---QDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYF 87
           A QLKK    E   ++   +KRKH RKRS   R +K   +A+ + L A+     E+   +
Sbjct: 5   ASQLKKNRDLEINAEEEPEKKRKH-RKRS---RDRKKKSDANASYLRAARAGHLEKALDY 60

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           +KN V  ++CN++GL ALH    +   E+V  LL   ANV+A   +  T LH A+  G  
Sbjct: 61  IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQ 207
            +VK+LV  GA++ A + +G  P  +   E  L+V++  +   G +Q    E    P   
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD-NGASQSLATEDGFTPLAV 179

Query: 208 MIADIHCMIAAGQDLDWIDAQGAT---LLHIAGANGYLRAAELLLDHGVRVDVKDWDGWE 264
            +   H  + +   L   D +G      LHIA      +AA LLL +    DV+   G+ 
Sbjct: 180 ALQQGHDQVVS--LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFT 237

Query: 265 PLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEE 304
           PLH AA +G + +A LL++  A++      D  P+ +  +
Sbjct: 238 PLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 63/250 (25%), Positives = 116/250 (46%), Gaps = 5/250 (2%)

Query: 81  AEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHA 140
           A+ V+  L+   SP+     G T LH    +  E++   LL HGA+++    + +TPLH 
Sbjct: 512 ADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHV 571

Query: 141 AATCGHINLVKILVQYGADLLAVNSDGNMPYDLC----EDEPTLDVIETCMAYQGITQEK 196
           AA  G + +  +L+Q  A   A    G  P  +       +  L +++   +     +  
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNG 631

Query: 197 INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVD 256
              + +A ++  +     ++  G D + +  QG   +H+A   G++    LLL     V+
Sbjct: 632 YTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN 691

Query: 257 VKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL-CEEEEFKVLLLELK 315
           + +  G  PLH AA   ++ +AE+LV+ GA + A+T M   P+ + C     K++   L+
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751

Query: 316 HKHDVIMKSQ 325
           H   V  K++
Sbjct: 752 HSAKVNAKTK 761



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 61/236 (25%), Positives = 108/236 (45%), Gaps = 7/236 (2%)

Query: 85  RYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATC 144
           +  L  K +P+    +G T LH  C  N  ++++LLL HGA++ A      TP+H AA  
Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443

Query: 145 GHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINE----M 200
           GH+N+V  L+ +GA     N  G     +       +V+   +      + K  +    +
Sbjct: 444 GHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503

Query: 201 RVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDW 260
            ++        +  ++  G   +     G T LH++   G+   A  LLDHG  + +   
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTK 563

Query: 261 DGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLC---EEEEFKVLLLE 313
            G+ PLH AA +G++++A LL+   AS  A       P+ +    + ++  +LLL+
Sbjct: 564 KGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLD 619



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 56/210 (26%), Positives = 95/210 (45%), Gaps = 4/210 (1%)

Query: 82  EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
           E     L+   SPD   + GLT LH     + +++  LLL  GA+ +A     +TPLH A
Sbjct: 579 EVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638

Query: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQG----ITQEKI 197
           A    +++   L++YGAD  AV   G     L   E  +D++   +          +  +
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL 698

Query: 198 NEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDV 257
             + +A ++  +     ++  G  +D     G T LH+    G ++    LL H  +V+ 
Sbjct: 699 TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNA 758

Query: 258 KDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287
           K  +G+ PLH AA  G   +  +L+ + AS
Sbjct: 759 KTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 69/226 (30%), Positives = 100/226 (44%), Gaps = 4/226 (1%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT 143
           V   + +  SP+  N  G TALH        E+V+ L+  GA V AK  +  TPLH +A 
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508

Query: 144 CGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCM---AYQGITQEK-INE 199
            G  ++V+ L+Q GA   A  + G  P  L   E   DV    +   A   IT +K    
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTP 568

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           + VA +   +   + ++      D     G T LH+A      + A LLLD G       
Sbjct: 569 LHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAA 628

Query: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE 305
            +G+ PLH AA   QM +A  L+ +GA  +A T      + L  +E
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQE 674



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 76/313 (24%), Positives = 138/313 (44%), Gaps = 12/313 (3%)

Query: 71  ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAK 130
           AL  A+ ++D +     L+N  + D+ ++ G T LH         +  LLL+  A V+  
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 131 DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCM--- 187
                TPLH A+  G+ N+VK+L+  GA + A   DG  P           V+E  +   
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 188 -AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAE 246
                 T+  ++ + +A +   +  +  ++     +D +     T LH+A   G+ + A+
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384

Query: 247 LLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEE 306
           +LLD     + K  +G+ PLH A    ++++ ELL+ HGAS+ A T     PI +     
Sbjct: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444

Query: 307 FKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSR--------GKVVRRASLSDRTNLY 358
              ++ +L H       + +R +++L     S  +         G  V   +  D+T L+
Sbjct: 445 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504

Query: 359 RKEYEGEAILWQR 371
                G+A + Q+
Sbjct: 505 ISARLGKADIVQQ 517



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 68/251 (27%), Positives = 108/251 (43%), Gaps = 9/251 (3%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT 143
           V+  L++ V  D    D LTALH        ++ K+LL   AN NAK    +TPLH A  
Sbjct: 350 VQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACK 409

Query: 144 CGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN----- 198
              I ++++L+++GA + AV   G  P  +      ++++   M + G +    N     
Sbjct: 410 KNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLM-HHGASPNTTNVRGET 468

Query: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVK 258
            + +A        +  ++  G  ++       T LHI+   G     + LL  G   +  
Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA 528

Query: 259 DWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE---EFKVLLLELK 315
              G+ PLH +A  G   +A  L+ HGASLS  T     P+ +  +    E   LLL+  
Sbjct: 529 TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKS 588

Query: 316 HKHDVIMKSQL 326
              D   KS L
Sbjct: 589 ASPDAAGKSGL 599



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 41/146 (28%), Positives = 67/146 (45%), Gaps = 4/146 (2%)

Query: 64  VSFEASVALLEASLRNDAEEVRYFLKNK-VSPDLCNEDGLTALHQCCIDNFEEIVKLLLS 122
           +S ++ +  L  + + D   V   L N+    D   + G T LH  C     +IV  LL 
Sbjct: 692 LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751

Query: 123 HGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDV 182
           H A VNAK    +TPLH AA  GH +++ +L+Q  A    +  +GN    +      + V
Sbjct: 752 HSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISV 811

Query: 183 IETCMAYQGITQEKINEMRVAPEQQM 208
           ++T      +T+E +    V  + +M
Sbjct: 812 VDTLKI---VTEETMTTTTVTEKHKM 834



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 25/90 (27%), Positives = 46/90 (51%)

Query: 216 IAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQM 275
           I  G D++  +  G   LH+A   G++     LL     VD     G   LH A+  GQ 
Sbjct: 61  IKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQA 120

Query: 276 QMAELLVSHGASLSARTSMDEMPIDLCEEE 305
           ++ ++LV++GA+++A++     P+ +  +E
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  110 bits (275), Expect = 3e-24
 Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 13/250 (5%)

Query: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
           N    V Y L +       ++ GL  LH  C     E+ +LL+ HGA+VN  D   +TPL
Sbjct: 695 NRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPL 754

Query: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN 198
           H AA  G   + K+L+++GAD    N DGN P DL ++  T D+ +       +      
Sbjct: 755 HEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDT-DIQDLLRGDAALLD---- 809

Query: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQG--ATLLHIAGANGYLRAAELLLDHGVRVD 256
               A ++  +A +   +   ++++  D QG  +T LH+A     L  AE LL+HG  V+
Sbjct: 810 ----AAKKGCLARVQ-KLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864

Query: 257 VKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI-DLCEEEEFKVLLLELK 315
            +D  G  PLH AA +G + +A LL+ +   ++A       P+ +  ++   ++  L L 
Sbjct: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA 924

Query: 316 HKHDVIMKSQ 325
           H  D  MK+Q
Sbjct: 925 HGADPTMKNQ 934



 Score =  108 bits (269), Expect = 2e-23
 Identities = 74/242 (30%), Positives = 117/242 (48%), Gaps = 19/242 (7%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT 143
           V + L+   +    ++ GL  LH  C     E+V LLL  GA+ NA+DN  +TPLH AA 
Sbjct: 232 VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAI 291

Query: 144 CGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVA 203
            G I++  +L+Q+GAD    N+DG    DL +        +  +  +    E +   R  
Sbjct: 292 KGKIDVCIVLLQHGADPNIRNTDGKSALDLADPS-----AKAVLTGEYKKDELLEAARSG 346

Query: 204 PEQQMIA-----DIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVK 258
            E++++A     +++C  +        D + +T LH+A     +R  +LLL HG  V  K
Sbjct: 347 NEEKLMALLTPLNVNCHAS--------DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398

Query: 259 DWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI-DLCEEEEFKVLLLELKHK 317
           D  G  PLH A  +G  ++ ELL+ HGA ++A       P+ +   +   +V  L L H 
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458

Query: 318 HD 319
            D
Sbjct: 459 AD 460



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 72/265 (27%), Positives = 124/265 (46%), Gaps = 8/265 (3%)

Query: 65  SFEASVALLEASLRNDAEEVRYFLKNK-VSPDLCNEDGLTALHQCCIDNFEEIVKLLLSH 123
           S E ++    ASL    ++V   L  K  + +  N+D +T LH        +++++L  H
Sbjct: 521 SHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580

Query: 124 GANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVI 183
           GA +NA D    T LH AA  GH+   ++L+ YG+D   ++  G     +  +     + 
Sbjct: 581 GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILS 640

Query: 184 ETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQG--ATLLHIAGANGY 241
           E+          ++ E   A + + +  +     + Q+++  D +G  +T LH A     
Sbjct: 641 ESTPIRTSDVDYRLLEASKAGDLETVKQL----CSSQNVNCRDLEGRHSTPLHFAAGYNR 696

Query: 242 LRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI-D 300
           +   E LL HG  V  KD  G  PLH A  +G  ++AELLV HGAS++        P+ +
Sbjct: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756

Query: 301 LCEEEEFKVLLLELKHKHDVIMKSQ 325
              + ++++  L LKH  D   K++
Sbjct: 757 AAAKGKYEICKLLLKHGADPTKKNR 781



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 66/244 (27%), Positives = 104/244 (42%), Gaps = 38/244 (15%)

Query: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
           N    V+  L++       ++ GL  LH  C     E+ +LLL HGA VNA D   +TPL
Sbjct: 380 NRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPL 439

Query: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN 198
           H AA+   + +  +L+ +GAD   VN  G    D+    PT ++ E  + Y+      + 
Sbjct: 440 HEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA---PTPELRER-LTYEFKGHSLLQ 495

Query: 199 EMRVA------------------PEQQMIADIHCMIAA---------------GQDLDWI 225
             R A                  P+    A +HC +A+               G +++  
Sbjct: 496 AAREADLAKVKKTLALEIINFKQPQSHETA-LHCAVASLHPKRKQVTELLLRKGANVNEK 554

Query: 226 DAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHG 285
           +    T LH+A    +    E+L  HG +++  D  G   LH AA  G +Q   LL+S+G
Sbjct: 555 NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYG 614

Query: 286 ASLS 289
           +  S
Sbjct: 615 SDPS 618



 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 39/119 (32%), Positives = 54/119 (45%), Gaps = 7/119 (5%)

Query: 55  RSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFE 114
           R T GR        S  L  A+  N+ E   Y L++    +  ++ GL  LH        
Sbjct: 831 RDTQGRN-------STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHV 883

Query: 115 EIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL 173
           +I  LL+ +   VNA D   +TPLH AA  G   L  +L+ +GAD    N +G  P DL
Sbjct: 884 DIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 1/88 (1%)

Query: 233 LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSART 292
           LH A   G     E LL  G  V  +D  G  PLH A  +G  ++  LL+  GA  +AR 
Sbjct: 220 LHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD 279

Query: 293 SMDEMPI-DLCEEEEFKVLLLELKHKHD 319
           + +  P+ +   + +  V ++ L+H  D
Sbjct: 280 NWNYTPLHEAAIKGKIDVCIVLLQHGAD 307



 Score = 30.4 bits (67), Expect = 4.5
 Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 3/63 (4%)

Query: 239 NGYLRAAELLLDHGVRVDVKDWDGWE--PLHAAAFWGQMQMAELLVSHGASLSARTSMDE 296
           NG +   + L+D    V+ KD  G +  PLH AA +G+  + E L+  GA++ AR     
Sbjct: 192 NGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGL 250

Query: 297 MPI 299
           +P+
Sbjct: 251 IPL 253


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  103 bits (257), Expect = 4e-22
 Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 18/247 (7%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           + + AL  A+L    E VR  +    + +  ++ G T L+    +N  E+VK LL +GAN
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGAD---------LLAVNSDGNMPYDLCEDE 177
            N    + +TPL  A   GH N+V  L+ YG           + A N D      L +++
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
           P  DV+         ++     + +A   + +     ++  G  +++    G T LHIA 
Sbjct: 197 PNPDVL---------SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
             G +    LLLD G +++ K  D   PLH AA  G ++++E+L+ HGA + A+T     
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 298 PIDLCEE 304
           PI +  +
Sbjct: 308 PIHMAAQ 314



 Score =  100 bits (250), Expect = 3e-21
 Identities = 86/286 (30%), Positives = 129/286 (45%), Gaps = 25/286 (8%)

Query: 57  TGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEI 116
           TG     V+      L  AS       V+  L+   SP++ N    T LH        E+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCED 176
            K LL + A VNAK  +  TPLH AA  GH N+VK+L++  A+     + G+ P  +   
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 177 EPTLDVI---------ETCMAYQGIT----QEKINEMRVAPEQQMIADIHCMIAAGQDLD 223
           E  ++ +         + CM  +G T      K  ++RVA E  +  D H   AAG++  
Sbjct: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA-ELLLERDAH-PNAAGKN-- 568

Query: 224 WIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVS 283
                G T LH+A  +  L   +LLL  G       W+G+ PLH AA   Q+++A  L+ 
Sbjct: 569 -----GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623

Query: 284 HGASLSARTSMDEMPIDLCEEE---EFKVLLLELKHKHDVIMKSQL 326
           +G S +A +     P+ L  +E   E   LLL  +   ++  KS L
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 66/254 (25%), Positives = 120/254 (47%), Gaps = 1/254 (0%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS     + V   L  ++  +   + G TALH   +   +E+V+ L+++GANVNA+  + 
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
           +TPL+ AA   H+ +VK L++ GA+      DG  P  +   +   +V+   + Y    +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171

Query: 195 EKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVR 254
            ++  + +A           ++    + D +   G T LHIA     L  A+LLL+ G  
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 255 VDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLEL 314
           V+    +G  PLH A+  G + M  LL+  GA +  +T  +  P+  C      V + E+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEI 290

Query: 315 KHKHDVIMKSQLRH 328
              H   ++++ ++
Sbjct: 291 LLDHGAPIQAKTKN 304



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/229 (23%), Positives = 107/229 (46%), Gaps = 4/229 (1%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+     E V   L+ + S     + G T LH         + +LLL   A+ NA     
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
            TPLH A    ++++VK+L+  G    +   +G  P  +   +  ++V  + + Y G   
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 195 EK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLD 250
            +    +  + +A ++     +  +++   + +  +  G T LH+    G++  A++L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 251 HGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           HGV VD     G+ PLH A+ +G +++ + L+ H A ++A+T +   P+
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 59/220 (26%), Positives = 101/220 (45%), Gaps = 4/220 (1%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L+    P+   ++GLT LH     N  +IVKLLL  G + ++     +TPLH AA    +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI----TQEKINEMRVA 203
            + + L+QYG    A +  G  P  L   E   +++   ++ Q       +  +  + + 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 204 PEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGW 263
            ++  +     +I  G  +D     G T LH+A   G ++  + LL H   V+ K   G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 264 EPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCE 303
            PLH AA  G   +  LL+ +GAS +  +S    P+ + +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 62/234 (26%), Positives = 106/234 (45%), Gaps = 14/234 (5%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS R +   VR  L      +   +D LT LH    +    I ++LL HGA + AK    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL---CEDEPTLDVI------ET 185
            +P+H AA   H++ V++L+QY A++  +  D   P  +   C       V+        
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 186 CMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
             A  G T      + +A ++  +  +  ++  G  +D +   G T LH+A   G+L   
Sbjct: 366 SRALNGFT-----PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           + LL  G   +V +     PLH AA  G  ++A+ L+ + A ++A+   D+ P+
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 62/250 (24%), Positives = 113/250 (45%), Gaps = 5/250 (2%)

Query: 73  LEASLRNDAEEVRYFLKNKVSP-DLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + RN    +   L +  +P     ++GL+ +H     +  + V+LLL + A ++   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE----TCM 187
            +  TPLH AA CGH  + K+L+  GA   +   +G  P  +   +  + V+E    T  
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 188 AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
           +   +T+  +  + VA     +  +  ++  G   +  + +  T LH+A   G+   A+ 
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEF 307
           LL +  +V+ K  D   PLH AA  G   M +LL+ + A+ +  T+    P+ +   E  
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 308 KVLLLELKHK 317
              +L L  K
Sbjct: 516 VETVLALLEK 525



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 42/147 (28%), Positives = 67/147 (45%), Gaps = 1/147 (0%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     S +    L  A+    AE V   L  + + +L N+ GLT LH    +    + 
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            +L+ HG  V+A     +TPLH A+  G+I LVK L+Q+ AD+ A    G  P      +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAP 204
              D++ T +   G +  +++     P
Sbjct: 745 GHTDIV-TLLLKNGASPNEVSSDGTTP 770



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 4/195 (2%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     ++     L  A+ +N  E  R  L+   S +  +  G+T LH    +   E+V
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            LLLS  AN N  +    TPLH  A  GH+ +  +L+++G  + A    G  P  +    
Sbjct: 652 ALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711

Query: 178 PTLDVIETCMAYQGITQEK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
             + +++  + +Q     K     + +  A +Q     +  ++  G   + + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771

Query: 234 HIAGANGYLRAAELL 248
            IA   GY+   ++L
Sbjct: 772 AIAKRLGYISVTDVL 786



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/87 (26%), Positives = 45/87 (51%)

Query: 219 GQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA 278
           G D++  +  G   LH+A   G+++    LL   + ++     G   LH AA  GQ ++ 
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 279 ELLVSHGASLSARTSMDEMPIDLCEEE 305
             LV++GA+++A++     P+ +  +E
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQE 121


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  103 bits (257), Expect = 4e-22
 Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 18/247 (7%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           + + AL  A+L    E VR  +    + +  ++ G T L+    +N  E+VK LL +GAN
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGAD---------LLAVNSDGNMPYDLCEDE 177
            N    + +TPL  A   GH N+V  L+ YG           + A N D      L +++
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
           P  DV+         ++     + +A   + +     ++  G  +++    G T LHIA 
Sbjct: 197 PNPDVL---------SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
             G +    LLLD G +++ K  D   PLH AA  G ++++E+L+ HGA + A+T     
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 298 PIDLCEE 304
           PI +  +
Sbjct: 308 PIHMAAQ 314



 Score =  100 bits (250), Expect = 3e-21
 Identities = 86/286 (30%), Positives = 129/286 (45%), Gaps = 25/286 (8%)

Query: 57  TGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEI 116
           TG     V+      L  AS       V+  L+   SP++ N    T LH        E+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCED 176
            K LL + A VNAK  +  TPLH AA  GH N+VK+L++  A+     + G+ P  +   
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 177 EPTLDVI---------ETCMAYQGIT----QEKINEMRVAPEQQMIADIHCMIAAGQDLD 223
           E  ++ +         + CM  +G T      K  ++RVA E  +  D H   AAG++  
Sbjct: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA-ELLLERDAH-PNAAGKN-- 568

Query: 224 WIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVS 283
                G T LH+A  +  L   +LLL  G       W+G+ PLH AA   Q+++A  L+ 
Sbjct: 569 -----GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623

Query: 284 HGASLSARTSMDEMPIDLCEEE---EFKVLLLELKHKHDVIMKSQL 326
           +G S +A +     P+ L  +E   E   LLL  +   ++  KS L
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 66/254 (25%), Positives = 120/254 (47%), Gaps = 1/254 (0%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS     + V   L  ++  +   + G TALH   +   +E+V+ L+++GANVNA+  + 
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
           +TPL+ AA   H+ +VK L++ GA+      DG  P  +   +   +V+   + Y    +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171

Query: 195 EKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVR 254
            ++  + +A           ++    + D +   G T LHIA     L  A+LLL+ G  
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 255 VDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLEL 314
           V+    +G  PLH A+  G + M  LL+  GA +  +T  +  P+  C      V + E+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEI 290

Query: 315 KHKHDVIMKSQLRH 328
              H   ++++ ++
Sbjct: 291 LLDHGAPIQAKTKN 304



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/229 (23%), Positives = 107/229 (46%), Gaps = 4/229 (1%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+     E V   L+ + S     + G T LH         + +LLL   A+ NA     
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
            TPLH A    ++++VK+L+  G    +   +G  P  +   +  ++V  + + Y G   
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 195 EK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLD 250
            +    +  + +A ++     +  +++   + +  +  G T LH+    G++  A++L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 251 HGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           HGV VD     G+ PLH A+ +G +++ + L+ H A ++A+T +   P+
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 59/220 (26%), Positives = 101/220 (45%), Gaps = 4/220 (1%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L+    P+   ++GLT LH     N  +IVKLLL  G + ++     +TPLH AA    +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI----TQEKINEMRVA 203
            + + L+QYG    A +  G  P  L   E   +++   ++ Q       +  +  + + 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 204 PEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGW 263
            ++  +     +I  G  +D     G T LH+A   G ++  + LL H   V+ K   G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 264 EPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCE 303
            PLH AA  G   +  LL+ +GAS +  +S    P+ + +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 62/234 (26%), Positives = 106/234 (45%), Gaps = 14/234 (5%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS R +   VR  L      +   +D LT LH    +    I ++LL HGA + AK    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL---CEDEPTLDVI------ET 185
            +P+H AA   H++ V++L+QY A++  +  D   P  +   C       V+        
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 186 CMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
             A  G T      + +A ++  +  +  ++  G  +D +   G T LH+A   G+L   
Sbjct: 366 SRALNGFT-----PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           + LL  G   +V +     PLH AA  G  ++A+ L+ + A ++A+   D+ P+
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 62/250 (24%), Positives = 113/250 (45%), Gaps = 5/250 (2%)

Query: 73  LEASLRNDAEEVRYFLKNKVSP-DLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + RN    +   L +  +P     ++GL+ +H     +  + V+LLL + A ++   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE----TCM 187
            +  TPLH AA CGH  + K+L+  GA   +   +G  P  +   +  + V+E    T  
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 188 AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
           +   +T+  +  + VA     +  +  ++  G   +  + +  T LH+A   G+   A+ 
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEF 307
           LL +  +V+ K  D   PLH AA  G   M +LL+ + A+ +  T+    P+ +   E  
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 308 KVLLLELKHK 317
              +L L  K
Sbjct: 516 VETVLALLEK 525



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 42/147 (28%), Positives = 67/147 (45%), Gaps = 1/147 (0%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     S +    L  A+    AE V   L  + + +L N+ GLT LH    +    + 
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            +L+ HG  V+A     +TPLH A+  G+I LVK L+Q+ AD+ A    G  P      +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAP 204
              D++ T +   G +  +++     P
Sbjct: 745 GHTDIV-TLLLKNGASPNEVSSDGTTP 770



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 4/195 (2%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     ++     L  A+ +N  E  R  L+   S +  +  G+T LH    +   E+V
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            LLLS  AN N  +    TPLH  A  GH+ +  +L+++G  + A    G  P  +    
Sbjct: 652 ALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711

Query: 178 PTLDVIETCMAYQGITQEK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
             + +++  + +Q     K     + +  A +Q     +  ++  G   + + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771

Query: 234 HIAGANGYLRAAELL 248
            IA   GY+   ++L
Sbjct: 772 AIAKRLGYISVTDVL 786



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/87 (26%), Positives = 45/87 (51%)

Query: 219 GQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA 278
           G D++  +  G   LH+A   G+++    LL   + ++     G   LH AA  GQ ++ 
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 279 ELLVSHGASLSARTSMDEMPIDLCEEE 305
             LV++GA+++A++     P+ +  +E
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQE 121


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  103 bits (257), Expect = 4e-22
 Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 18/247 (7%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           + + AL  A+L    E VR  +    + +  ++ G T L+    +N  E+VK LL +GAN
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGAD---------LLAVNSDGNMPYDLCEDE 177
            N    + +TPL  A   GH N+V  L+ YG           + A N D      L +++
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
           P  DV+         ++     + +A   + +     ++  G  +++    G T LHIA 
Sbjct: 197 PNPDVL---------SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
             G +    LLLD G +++ K  D   PLH AA  G ++++E+L+ HGA + A+T     
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 298 PIDLCEE 304
           PI +  +
Sbjct: 308 PIHMAAQ 314



 Score =  100 bits (250), Expect = 3e-21
 Identities = 86/286 (30%), Positives = 129/286 (45%), Gaps = 25/286 (8%)

Query: 57  TGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEI 116
           TG     V+      L  AS       V+  L+   SP++ N    T LH        E+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCED 176
            K LL + A VNAK  +  TPLH AA  GH N+VK+L++  A+     + G+ P  +   
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 177 EPTLDVI---------ETCMAYQGIT----QEKINEMRVAPEQQMIADIHCMIAAGQDLD 223
           E  ++ +         + CM  +G T      K  ++RVA E  +  D H   AAG++  
Sbjct: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA-ELLLERDAH-PNAAGKN-- 568

Query: 224 WIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVS 283
                G T LH+A  +  L   +LLL  G       W+G+ PLH AA   Q+++A  L+ 
Sbjct: 569 -----GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623

Query: 284 HGASLSARTSMDEMPIDLCEEE---EFKVLLLELKHKHDVIMKSQL 326
           +G S +A +     P+ L  +E   E   LLL  +   ++  KS L
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 66/254 (25%), Positives = 120/254 (47%), Gaps = 1/254 (0%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS     + V   L  ++  +   + G TALH   +   +E+V+ L+++GANVNA+  + 
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
           +TPL+ AA   H+ +VK L++ GA+      DG  P  +   +   +V+   + Y    +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171

Query: 195 EKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVR 254
            ++  + +A           ++    + D +   G T LHIA     L  A+LLL+ G  
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 255 VDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLEL 314
           V+    +G  PLH A+  G + M  LL+  GA +  +T  +  P+  C      V + E+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEI 290

Query: 315 KHKHDVIMKSQLRH 328
              H   ++++ ++
Sbjct: 291 LLDHGAPIQAKTKN 304



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/229 (23%), Positives = 107/229 (46%), Gaps = 4/229 (1%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+     E V   L+ + S     + G T LH         + +LLL   A+ NA     
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
            TPLH A    ++++VK+L+  G    +   +G  P  +   +  ++V  + + Y G   
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 195 EK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLD 250
            +    +  + +A ++     +  +++   + +  +  G T LH+    G++  A++L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 251 HGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           HGV VD     G+ PLH A+ +G +++ + L+ H A ++A+T +   P+
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 59/220 (26%), Positives = 101/220 (45%), Gaps = 4/220 (1%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L+    P+   ++GLT LH     N  +IVKLLL  G + ++     +TPLH AA    +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI----TQEKINEMRVA 203
            + + L+QYG    A +  G  P  L   E   +++   ++ Q       +  +  + + 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 204 PEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGW 263
            ++  +     +I  G  +D     G T LH+A   G ++  + LL H   V+ K   G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 264 EPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCE 303
            PLH AA  G   +  LL+ +GAS +  +S    P+ + +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 62/234 (26%), Positives = 106/234 (45%), Gaps = 14/234 (5%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS R +   VR  L      +   +D LT LH    +    I ++LL HGA + AK    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL---CEDEPTLDVI------ET 185
            +P+H AA   H++ V++L+QY A++  +  D   P  +   C       V+        
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 186 CMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
             A  G T      + +A ++  +  +  ++  G  +D +   G T LH+A   G+L   
Sbjct: 366 SRALNGFT-----PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           + LL  G   +V +     PLH AA  G  ++A+ L+ + A ++A+   D+ P+
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 62/250 (24%), Positives = 113/250 (45%), Gaps = 5/250 (2%)

Query: 73  LEASLRNDAEEVRYFLKNKVSP-DLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + RN    +   L +  +P     ++GL+ +H     +  + V+LLL + A ++   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE----TCM 187
            +  TPLH AA CGH  + K+L+  GA   +   +G  P  +   +  + V+E    T  
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 188 AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
           +   +T+  +  + VA     +  +  ++  G   +  + +  T LH+A   G+   A+ 
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEF 307
           LL +  +V+ K  D   PLH AA  G   M +LL+ + A+ +  T+    P+ +   E  
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 308 KVLLLELKHK 317
              +L L  K
Sbjct: 516 VETVLALLEK 525



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 42/147 (28%), Positives = 67/147 (45%), Gaps = 1/147 (0%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     S +    L  A+    AE V   L  + + +L N+ GLT LH    +    + 
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            +L+ HG  V+A     +TPLH A+  G+I LVK L+Q+ AD+ A    G  P      +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAP 204
              D++ T +   G +  +++     P
Sbjct: 745 GHTDIV-TLLLKNGASPNEVSSDGTTP 770



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 4/195 (2%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     ++     L  A+ +N  E  R  L+   S +  +  G+T LH    +   E+V
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            LLLS  AN N  +    TPLH  A  GH+ +  +L+++G  + A    G  P  +    
Sbjct: 652 ALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711

Query: 178 PTLDVIETCMAYQGITQEK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
             + +++  + +Q     K     + +  A +Q     +  ++  G   + + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771

Query: 234 HIAGANGYLRAAELL 248
            IA   GY+   ++L
Sbjct: 772 AIAKRLGYISVTDVL 786



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/87 (26%), Positives = 45/87 (51%)

Query: 219 GQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA 278
           G D++  +  G   LH+A   G+++    LL   + ++     G   LH AA  GQ ++ 
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 279 ELLVSHGASLSARTSMDEMPIDLCEEE 305
             LV++GA+++A++     P+ +  +E
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQE 121


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  103 bits (257), Expect = 4e-22
 Identities = 69/247 (27%), Positives = 115/247 (46%), Gaps = 18/247 (7%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           + + AL  A+L    E VR  +    + +  ++ G T L+    +N  E+VK LL +GAN
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGAD---------LLAVNSDGNMPYDLCEDE 177
            N    + +TPL  A   GH N+V  L+ YG           + A N D      L +++
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
           P  DV+         ++     + +A   + +     ++  G  +++    G T LHIA 
Sbjct: 197 PNPDVL---------SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIAS 247

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
             G +    LLLD G +++ K  D   PLH AA  G ++++E+L+ HGA + A+T     
Sbjct: 248 RRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLS 307

Query: 298 PIDLCEE 304
           PI +  +
Sbjct: 308 PIHMAAQ 314



 Score =  100 bits (250), Expect = 3e-21
 Identities = 86/286 (30%), Positives = 129/286 (45%), Gaps = 25/286 (8%)

Query: 57  TGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEI 116
           TG     V+      L  AS       V+  L+   SP++ N    T LH        E+
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEV 452

Query: 117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCED 176
            K LL + A VNAK  +  TPLH AA  GH N+VK+L++  A+     + G+ P  +   
Sbjct: 453 AKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAR 512

Query: 177 EPTLDVI---------ETCMAYQGIT----QEKINEMRVAPEQQMIADIHCMIAAGQDLD 223
           E  ++ +         + CM  +G T      K  ++RVA E  +  D H   AAG++  
Sbjct: 513 EGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA-ELLLERDAH-PNAAGKN-- 568

Query: 224 WIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVS 283
                G T LH+A  +  L   +LLL  G       W+G+ PLH AA   Q+++A  L+ 
Sbjct: 569 -----GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623

Query: 284 HGASLSARTSMDEMPIDLCEEE---EFKVLLLELKHKHDVIMKSQL 326
           +G S +A +     P+ L  +E   E   LLL  +   ++  KS L
Sbjct: 624 YGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGL 669



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 66/254 (25%), Positives = 120/254 (47%), Gaps = 1/254 (0%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS     + V   L  ++  +   + G TALH   +   +E+V+ L+++GANVNA+  + 
Sbjct: 52  ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKG 111

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
           +TPL+ AA   H+ +VK L++ GA+      DG  P  +   +   +V+   + Y    +
Sbjct: 112 FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171

Query: 195 EKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVR 254
            ++  + +A           ++    + D +   G T LHIA     L  A+LLL+ G  
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 255 VDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLEL 314
           V+    +G  PLH A+  G + M  LL+  GA +  +T  +  P+  C      V + E+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLH-CAARNGHVRISEI 290

Query: 315 KHKHDVIMKSQLRH 328
              H   ++++ ++
Sbjct: 291 LLDHGAPIQAKTKN 304



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 54/229 (23%), Positives = 107/229 (46%), Gaps = 4/229 (1%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+     E V   L+ + S     + G T LH         + +LLL   A+ NA     
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
            TPLH A    ++++VK+L+  G    +   +G  P  +   +  ++V  + + Y G   
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 195 EK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLD 250
            +    +  + +A ++     +  +++   + +  +  G T LH+    G++  A++L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 251 HGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           HGV VD     G+ PLH A+ +G +++ + L+ H A ++A+T +   P+
Sbjct: 690 HGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPL 738



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 59/220 (26%), Positives = 101/220 (45%), Gaps = 4/220 (1%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L+    P+   ++GLT LH     N  +IVKLLL  G + ++     +TPLH AA    +
Sbjct: 556 LERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQV 615

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI----TQEKINEMRVA 203
            + + L+QYG    A +  G  P  L   E   +++   ++ Q       +  +  + + 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 204 PEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGW 263
            ++  +     +I  G  +D     G T LH+A   G ++  + LL H   V+ K   G+
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 264 EPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCE 303
            PLH AA  G   +  LL+ +GAS +  +S    P+ + +
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score = 85.9 bits (211), Expect = 9e-17
 Identities = 62/234 (26%), Positives = 106/234 (45%), Gaps = 14/234 (5%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           AS R +   VR  L      +   +D LT LH    +    I ++LL HGA + AK    
Sbjct: 246 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 305

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL---CEDEPTLDVI------ET 185
            +P+H AA   H++ V++L+QY A++  +  D   P  +   C       V+        
Sbjct: 306 LSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN 365

Query: 186 CMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
             A  G T      + +A ++  +  +  ++  G  +D +   G T LH+A   G+L   
Sbjct: 366 SRALNGFT-----PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           + LL  G   +V +     PLH AA  G  ++A+ L+ + A ++A+   D+ P+
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 62/250 (24%), Positives = 113/250 (45%), Gaps = 5/250 (2%)

Query: 73  LEASLRNDAEEVRYFLKNKVSP-DLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + RN    +   L +  +P     ++GL+ +H     +  + V+LLL + A ++   
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE----TCM 187
            +  TPLH AA CGH  + K+L+  GA   +   +G  P  +   +  + V+E    T  
Sbjct: 336 LDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGA 395

Query: 188 AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
           +   +T+  +  + VA     +  +  ++  G   +  + +  T LH+A   G+   A+ 
Sbjct: 396 SIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKY 455

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEF 307
           LL +  +V+ K  D   PLH AA  G   M +LL+ + A+ +  T+    P+ +   E  
Sbjct: 456 LLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515

Query: 308 KVLLLELKHK 317
              +L L  K
Sbjct: 516 VETVLALLEK 525



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 42/147 (28%), Positives = 67/147 (45%), Gaps = 1/147 (0%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     S +    L  A+    AE V   L  + + +L N+ GLT LH    +    + 
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            +L+ HG  V+A     +TPLH A+  G+I LVK L+Q+ AD+ A    G  P      +
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAP 204
              D++ T +   G +  +++     P
Sbjct: 745 GHTDIV-TLLLKNGASPNEVSSDGTTP 770



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 47/195 (24%), Positives = 84/195 (43%), Gaps = 4/195 (2%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           GG     ++     L  A+ +N  E  R  L+   S +  +  G+T LH    +   E+V
Sbjct: 592 GGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMV 651

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            LLLS  AN N  +    TPLH  A  GH+ +  +L+++G  + A    G  P  +    
Sbjct: 652 ALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHY 711

Query: 178 PTLDVIETCMAYQGITQEK----INEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
             + +++  + +Q     K     + +  A +Q     +  ++  G   + + + G T L
Sbjct: 712 GNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771

Query: 234 HIAGANGYLRAAELL 248
            IA   GY+   ++L
Sbjct: 772 AIAKRLGYISVTDVL 786



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/87 (26%), Positives = 45/87 (51%)

Query: 219 GQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA 278
           G D++  +  G   LH+A   G+++    LL   + ++     G   LH AA  GQ ++ 
Sbjct: 35  GVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 94

Query: 279 ELLVSHGASLSARTSMDEMPIDLCEEE 305
             LV++GA+++A++     P+ +  +E
Sbjct: 95  RELVNYGANVNAQSQKGFTPLYMAAQE 121


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  102 bits (253), Expect = 1e-21
 Identities = 70/238 (29%), Positives = 111/238 (46%), Gaps = 9/238 (3%)

Query: 71  ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAK 130
           AL  A+     E V+  L    + +  ++    A+H        E+VKLL+SHGA V  K
Sbjct: 143 ALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202

Query: 131 DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL-CEDEPTLDVIETCMAY 189
           D + +TPLHAAA+ G I++VK L+  G D+   N+ GN P  + C +    DV+   +  
Sbjct: 203 DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQ--DVVVNELID 260

Query: 190 QGITQEKINEMRVAPEQQMIADIH------CMIAAGQDLDWIDAQGATLLHIAGANGYLR 243
            G    + NE    P     A  H       ++  G D++     G T LH+   +G   
Sbjct: 261 CGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFS 320

Query: 244 AAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
            ++ ++  G  +D +D +G  PLH AA +G   +   L++ GA  + R      P+ L
Sbjct: 321 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHL 378



 Score = 89.7 bits (221), Expect = 6e-18
 Identities = 67/302 (22%), Positives = 130/302 (43%), Gaps = 6/302 (1%)

Query: 71  ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAK 130
           +L++A    D +EVR  +  K   +  + +  T LH        EI++LL+  GA VNAK
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70

Query: 131 DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQ 190
           D++  TPLH A        V++L+++ AD+ A + +   P  +      +   E  +   
Sbjct: 71  DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130

Query: 191 GITQEKINEMRVAPEQQMIAD----IHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAE 246
                     R A      +     +  +++ G +++  D +    +H A   G++   +
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVK 190

Query: 247 LLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEE 306
           LL+ HG  V  KD   + PLHAAA  G + + + L+  G  ++   +    P+ +     
Sbjct: 191 LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNG 250

Query: 307 FKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEA 366
             V++ EL     ++  +Q   K       ++A + G +     + +  ++  K  +G+ 
Sbjct: 251 QDVVVNELIDCGAIV--NQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKT 308

Query: 367 IL 368
            L
Sbjct: 309 PL 310



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 69/232 (29%), Positives = 104/232 (44%), Gaps = 24/232 (10%)

Query: 73  LEASLRNDAEEVRYFLKNK-VSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  S+ N   +  Y L NK  + D  ++ G TALH+  +   EE V  LL HGA    +D
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD 716

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQG 191
           +   TP+H +A CGHI ++  L+Q  A + A  +  +            +  ETC+    
Sbjct: 717 SRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCV---- 772

Query: 192 ITQEKINEMRV--APEQQMIADIHCMI------AAGQDLDWI--------DAQGATLLHI 235
              E + E  V    E    + +HC +      AA   +D +        D++G T LH 
Sbjct: 773 ---ELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHA 829

Query: 236 AGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287
           A    ++   +LLL H  +V+  D  G  PL  AA  GQ    E+LVS  ++
Sbjct: 830 AAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASA 881



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 70/283 (24%), Positives = 121/283 (42%), Gaps = 41/283 (14%)

Query: 60  RRKKVSF---EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEI 116
           +++ V+F   E    L  A+   DAE +   + +    +  +   LT LH+      EE 
Sbjct: 30  KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 89

Query: 117 VKLLLSHGANVNAKDNELWTPLHAAAT--------------------------------- 143
           V++LL H A+VNA+D    TPLH AA                                  
Sbjct: 90  VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149

Query: 144 CGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGIT----QEKINE 199
            GH  +VK+L+  GA++ A +               ++V++  +++        ++    
Sbjct: 150 SGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTP 209

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           +  A    MI+ +  ++  G D++  +A G T LH+A  NG       L+D G  V+ K+
Sbjct: 210 LHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN 269

Query: 260 WDGWEPLH-AAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
             G+ PLH AAA        ELLV +GA ++ ++   + P+ +
Sbjct: 270 EKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHM 312



 Score = 76.3 bits (186), Expect = 7e-14
 Identities = 63/221 (28%), Positives = 97/221 (43%), Gaps = 5/221 (2%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT 143
           V+Y L   V  +  N  G T LH  C +  + +V  L+  GA VN K+ + +TPLH AA 
Sbjct: 222 VKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAA 281

Query: 144 CGHINL-VKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ-EKIN--- 198
             H  L +++LV  GAD+   + DG  P  +          +T +    +   E  N   
Sbjct: 282 STHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNT 341

Query: 199 EMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVK 258
            + +A        I+ +I +G D       G   LH+A  +G+      LL  G  +D  
Sbjct: 342 PLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 401

Query: 259 DWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           D  G   LHAAA  G ++   LL++ GA  + +      P+
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 59/197 (29%), Positives = 90/197 (45%), Gaps = 5/197 (2%)

Query: 98  NEDGLTALHQCCIDNFEEI-VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQY 156
           NE G T LH         + ++LL+ +GA+VN K  +  TPLH  A  G  +  + ++Q 
Sbjct: 269 NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS 328

Query: 157 GADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEK----INEMRVAPEQQMIADI 212
           GA +   + +GN P  +        +I T +     T ++    +  + +A         
Sbjct: 329 GAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCC 388

Query: 213 HCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFW 272
             ++++G D+D  D  G T LH A A G L    LLL+ G   + KD  G  PLH AA  
Sbjct: 389 RKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAAN 448

Query: 273 GQMQMAELLVSHGASLS 289
              Q    LV  GAS++
Sbjct: 449 CNYQCLFALVGSGASVN 465



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 63/247 (25%), Positives = 102/247 (41%), Gaps = 20/247 (8%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSH----------G 124
           A+   D + + Y L+N  +P + ++ G  A+H          ++L+ S           G
Sbjct: 479 ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSG 538

Query: 125 ANVNAKDNELWT--PLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDV 182
            ++ +  +   T  PLH AA  GH   +++LVQ   DL   NS G  P DL   +  ++ 
Sbjct: 539 TDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVEC 598

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIH-----CMIAAGQDLDWIDAQ---GATLLH 234
           ++  +        K   ++  P      + H      +I   +  + +D Q   G T L 
Sbjct: 599 VDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLM 658

Query: 235 IAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSM 294
           ++  NG+      LL+ G  VD KD  G   LH  A  G  +  + L+ HGA    R S 
Sbjct: 659 LSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSR 718

Query: 295 DEMPIDL 301
              PI L
Sbjct: 719 GRTPIHL 725



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 65/249 (26%), Positives = 102/249 (40%), Gaps = 21/249 (8%)

Query: 73  LEASLRNDAEEVRYFLKNKVSP----DLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVN 128
           + A+  N   E    L     P    D+ + +G T L    ++   + V  LL+ GANV+
Sbjct: 621 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 680

Query: 129 AKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMA 188
           AKD    T LH  A  GH   V  L+Q+GA  L  +S G  P  L      + V+   + 
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 740

Query: 189 YQGITQEKINEMRVAPEQQMIADIHCMIAAGQD-----------LDWIDAQGATLLHIAG 237
               +   ++      +      +H     G +               +    + LH A 
Sbjct: 741 ----SAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796

Query: 238 ANGYLRAAELLLD--HGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMD 295
            N    AAE+L+D      V+  D  G  PLHAAAF   ++  +LL+SH A +++  S  
Sbjct: 797 INDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTG 856

Query: 296 EMPIDLCEE 304
           + P+ +  E
Sbjct: 857 KTPLMMAAE 865



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 68/254 (26%), Positives = 112/254 (44%), Gaps = 25/254 (9%)

Query: 56  STGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEE 115
           ++G    K        L  A+L   ++  R  L +    D  ++ G T LH        E
Sbjct: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419

Query: 116 IVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCE 175
            + LLL+ GA+ N KD    +PLH AA   +   +  LV  GA +  ++  G  P     
Sbjct: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA- 478

Query: 176 DEPTLDVIETCMAY-------QGITQEK-INEMRVAPEQ------QMIA-----DIHCMI 216
              T D    C+ Y        GI  ++  N +  +         Q+IA     D+  M 
Sbjct: 479 --ATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV-LME 535

Query: 217 AAGQDLDWIDAQGATL--LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQ 274
            +G D+       AT+  LH+A  +G+ +A E+L+   + +DV++  G  PL  AAF G 
Sbjct: 536 TSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGH 595

Query: 275 MQMAELLVSHGASL 288
           ++  ++L++ GAS+
Sbjct: 596 VECVDVLINQGASI 609



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 54/220 (24%), Positives = 87/220 (39%), Gaps = 42/220 (19%)

Query: 93  SPDLCNEDGLTALHQCCIDNFEEIVKLLLSH----------------------------- 123
           +P   +  G TALH  C +  E  V+LLL                               
Sbjct: 748 NPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEML 807

Query: 124 ----GAN-VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEP 178
               GA+ VNA D++  TPLHAAA   H+  +++L+ + A + +V+S G  P  +  +  
Sbjct: 808 IDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENG 867

Query: 179 TLDVIETCMAYQGIT-----QEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATL- 232
             + +E  ++            K   + +A  +        ++    D + I+A  A L 
Sbjct: 868 QTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ 927

Query: 233 --LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAA 270
             LH+A  NG     + LL  G  V   D +G+ P  A A
Sbjct: 928 TPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 47/186 (25%), Positives = 76/186 (40%), Gaps = 6/186 (3%)

Query: 90  NKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINL 149
           N    ++ ++DG T LH   +       + ++  GA ++ +D    TPLH AA  GH  L
Sbjct: 295 NGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELL 354

Query: 150 VKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINE-----MRVAP 204
           +  L+  GAD       G  P  L       D     ++  G   +  ++     +  A 
Sbjct: 355 INTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS-SGFDIDTPDDFGRTCLHAAA 413

Query: 205 EQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWE 264
               +  ++ ++  G D +  D  G + LH A AN   +    L+  G  V+  D  G  
Sbjct: 414 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT 473

Query: 265 PLHAAA 270
           PLH AA
Sbjct: 474 PLHYAA 479



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 52/240 (21%), Positives = 92/240 (38%), Gaps = 31/240 (12%)

Query: 101 GLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADL 160
           G+  LH   +  F +  + LLS G +++  D+   T LHAAA  G++  + +L+  GAD 
Sbjct: 372 GMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADF 431

Query: 161 LAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQ 220
              +  G  P                             +  A        +  ++ +G 
Sbjct: 432 NKKDKFGRSP-----------------------------LHYAAANCNYQCLFALVGSGA 462

Query: 221 DLDWIDAQGATLLHIAGANGY-LRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAE 279
            ++ +D +G T LH A  +    +  E LL +     ++D  G+  +H +A +G     +
Sbjct: 463 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 522

Query: 280 LLVSH-GASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSS 338
           L+ S     +   TS  +M  D         L L   H H   ++  ++    L  R SS
Sbjct: 523 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 37/106 (34%), Positives = 52/106 (49%), Gaps = 8/106 (7%)

Query: 88  LKNKVSPDLCNEDGL--TALHQCCIDNFEEIVKLLLSHGAN---VNAKDNELWTPLHAAA 142
           L +  S +L  +D    TALH  C    E    L+L    +   +NA +  L TPLH AA
Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAA 934

Query: 143 TCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMA 188
             G   +V+ L+  GA +LAV+ +G  P   C   P  DV + C+A
Sbjct: 935 RNGLTMVVQELLGKGASVLAVDENGYTPALAC--APNKDVAD-CLA 977


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  100 bits (250), Expect = 3e-21
 Identities = 86/364 (23%), Positives = 144/364 (39%), Gaps = 86/364 (23%)

Query: 42  QDLQHRKRKHERKRSTGGRRKKVS-FEASVALLEASLRNDAEEVRYFLKNKVSPDLCNED 100
           +D   +    E+   +  RRK+    +++ + L A+   + ++V  +LK  +  + CN++
Sbjct: 4   EDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQN 63

Query: 101 GL---------------------------------TALHQCCIDNFEEIVKLLLSHGANV 127
           GL                                 TALH   +    E+VK+L+  GAN+
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 128 NAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE---------- 177
           NA+    +TPL+ AA   HI++VK L++ GA+      DG  P  +   +          
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 178 ----------PTLDV---------------------IETCMAYQGITQEKINEMRVAPEQ 206
                     P L +                     +++ M     T+     + +A   
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243

Query: 207 QMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPL 266
             +     ++  G  +D+    G T LH+A   G     +LLLD G ++D K  DG  PL
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303

Query: 267 HAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQL 326
           H AA  G  Q+ ELL+  GA L ART     P+ +  + +           H   +K  L
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLL 352

Query: 327 RHKS 330
           +HK+
Sbjct: 353 QHKA 356



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 70/226 (30%), Positives = 108/226 (47%), Gaps = 4/226 (1%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT 143
           V   L+N  SPD+ N  G TALH        E+V+ LL +GA V+A+  E  TPLH A+ 
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506

Query: 144 CGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDV----IETCMAYQGITQEKINE 199
            G   +V++L+Q+ A   A  ++G  P  +   E  +DV    +E   A+   T++    
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           + VA +   +     ++      D     G T LH+A      + A LLL+ G       
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE 305
            +G+ PLH AA   QMQ+A  L+++GA  +  T     P+ L  +E
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 66/230 (28%), Positives = 107/230 (46%), Gaps = 6/230 (2%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+  +  E V++ L++K   D    D LTALH         + KLLL   AN NA+    
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 398

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
           +TPLH A     I ++++LV+YGA + A+   G  P  +      L+++   +   G + 
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGASP 457

Query: 195 EKIN-----EMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLL 249
           +  N      + +A     +  + C++  G  +D    +  T LHIA   G     +LLL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 250 DHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
            H    D    +G+ PLH +A  GQ+ +A +L+  GA+ S  T     P+
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 71/259 (27%), Positives = 119/259 (45%), Gaps = 8/259 (3%)

Query: 73  LEASLRNDAEEVRYFLKNKVSPDLCN-EDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + R+  ++V   L  + +P L   ++GL+ LH     +  E VK LL H A V+   
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY-- 189
            +  T LH AA CGH  + K+L+   A+  A   +G  P  +   +  + V+E  + Y  
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422

Query: 190 --QGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
             Q IT+  +  + VA     +  +  ++  G   D  + +G T LH+A   G +     
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE-- 305
           LL +G  VD +  +   PLH A+  G+ ++ +LL+ H A   A T+    P+ +   E  
Sbjct: 483 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542

Query: 306 -EFKVLLLELKHKHDVIMK 323
            +   +LLE    H +  K
Sbjct: 543 VDVASVLLEAGAAHSLATK 561



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 71/271 (26%), Positives = 120/271 (44%), Gaps = 43/271 (15%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L    + D    +G+T LH         +VKLLL  G  ++AK  +  TPLH AA  GH 
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCE------------------DEPTLDVIET---- 185
            +V++L++ GA LLA   +G  P  +                    D+ TLD +      
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372

Query: 186 --CMAYQGITQEKINE--------------MRVAPEQQMIADIHCMIAAGQDLDWIDAQG 229
             C  Y+ +T+  +++              + +A ++  I  +  ++  G  +  I   G
Sbjct: 373 AHCGHYR-VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 230 ATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLS 289
            T +H+A   G+L    LLL +G   DV +  G   LH AA  GQ+++   L+ +GA + 
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 290 ARTSMDEMPIDLC----EEEEFKVLLLELKH 316
           AR   ++ P+ +     + E  ++LL  + H
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 5/264 (1%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           E    L  AS     E V+  L++   PD    +G T LH    +   ++  +LL  GA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC----EDEPTLDV 182
            +    + +TPLH AA  G +++ K+L+Q  A   +   +G  P  +       +  L +
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYL 242
           +E   +     +     + +A ++  +     ++  G + + +  QG T LH+A   G+ 
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675

Query: 243 RAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP-IDL 301
               LLLD G  + +    G   LH AA   ++ +A++L  HGA   A T +   P I  
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735

Query: 302 CEEEEFKVLLLELKHKHDVIMKSQ 325
           C     K++   LK   +V  K++
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTK 759



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 59/214 (27%), Positives = 99/214 (46%), Gaps = 6/214 (2%)

Query: 85  RYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATC 144
           +  L+ + + D   ++GLT LH     + +++  LLL  GA+ +A     +TPLH AA  
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639

Query: 145 GHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI-----TQEKINE 199
             + +   L+ YGA+   V   G  P  L   E   D++ T +  +G      T+  +  
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV-TLLLDKGANIHMSTKSGLTS 698

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           + +A ++  +     +   G D D     G T L +A   G ++    LL  G  V+ K 
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 758

Query: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTS 293
            +G+ PLH AA  G   +  +L+ HGA  +A T+
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 67/258 (25%), Positives = 107/258 (41%), Gaps = 5/258 (1%)

Query: 65  SFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHG 124
           +     AL  A+     E VR  L+N    D    +  T LH        EIV+LLL H 
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520

Query: 125 ANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE 184
           A+ +A     +TPLH +A  G +++  +L++ GA        G  P  +     +LDV +
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580

Query: 185 TCM----AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG 240
             +    A     +  +  + VA           ++  G         G T LHIA    
Sbjct: 581 LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640

Query: 241 YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
            ++ A  LL++G   ++    G  PLH A+  G   M  LL+  GA++   T      + 
Sbjct: 641 QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 700

Query: 301 LCEEEEFKVLLLELKHKH 318
           L  +E+ KV + ++  KH
Sbjct: 701 LAAQED-KVNVADILTKH 717



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 39/128 (30%), Positives = 63/128 (49%), Gaps = 1/128 (0%)

Query: 59  GRRKKVSFEASVALLEASLRNDAEEVRYFL-KNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           G    +S ++ +  L  + + D   V   L K+    D   + G T L   C     ++V
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
             LL  GANVNAK    +TPLH AA  GH +++ +L+Q+GA   A  ++GN    + +  
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804

Query: 178 PTLDVIET 185
             + V++T
Sbjct: 805 GYISVVDT 812



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 48/210 (22%), Positives = 90/210 (42%), Gaps = 22/210 (10%)

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYL 242
           I TC       Q  +N + +A ++  +  +  ++  G  +D    +G T LHIA   G  
Sbjct: 57  INTC------NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110

Query: 243 RAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLC 302
              ++L+  G  ++ +  +G+ PL+ AA    + + + L+ +GA+ S  T     P+ + 
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170

Query: 303 EEE---EFKVLLLE--------LKHKHDVIMKSQLRHKSSLSRRTSSAGSRGK-VVRRAS 350
            ++   +   +LLE        L   H    K   +  + L +   +A  + K +V R +
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230

Query: 351 LSDRTNLYRKEYEGE----AILWQRSAAED 376
            S  T L+   + G      +L  R AA D
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/82 (30%), Positives = 38/82 (46%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L+ A    + + V + LK   + +   ++G T LHQ        I+ +LL HGA  NA  
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791

Query: 132 NELWTPLHAAATCGHINLVKIL 153
               T L  A   G+I++V  L
Sbjct: 792 ANGNTALAIAKRLGYISVVDTL 813


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  100 bits (250), Expect = 3e-21
 Identities = 86/364 (23%), Positives = 144/364 (39%), Gaps = 86/364 (23%)

Query: 42  QDLQHRKRKHERKRSTGGRRKKVS-FEASVALLEASLRNDAEEVRYFLKNKVSPDLCNED 100
           +D   +    E+   +  RRK+    +++ + L A+   + ++V  +LK  +  + CN++
Sbjct: 4   EDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQN 63

Query: 101 GL---------------------------------TALHQCCIDNFEEIVKLLLSHGANV 127
           GL                                 TALH   +    E+VK+L+  GAN+
Sbjct: 64  GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123

Query: 128 NAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE---------- 177
           NA+    +TPL+ AA   HI++VK L++ GA+      DG  P  +   +          
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183

Query: 178 ----------PTLDV---------------------IETCMAYQGITQEKINEMRVAPEQ 206
                     P L +                     +++ M     T+     + +A   
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243

Query: 207 QMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPL 266
             +     ++  G  +D+    G T LH+A   G     +LLLD G ++D K  DG  PL
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPL 303

Query: 267 HAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQL 326
           H AA  G  Q+ ELL+  GA L ART     P+ +  + +           H   +K  L
Sbjct: 304 HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGD-----------HVECVKHLL 352

Query: 327 RHKS 330
           +HK+
Sbjct: 353 QHKA 356



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 70/226 (30%), Positives = 108/226 (47%), Gaps = 4/226 (1%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT 143
           V   L+N  SPD+ N  G TALH        E+V+ LL +GA V+A+  E  TPLH A+ 
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 506

Query: 144 CGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDV----IETCMAYQGITQEKINE 199
            G   +V++L+Q+ A   A  ++G  P  +   E  +DV    +E   A+   T++    
Sbjct: 507 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 566

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           + VA +   +     ++      D     G T LH+A      + A LLL+ G       
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626

Query: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE 305
            +G+ PLH AA   QMQ+A  L+++GA  +  T     P+ L  +E
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 66/230 (28%), Positives = 107/230 (46%), Gaps = 6/230 (2%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+  +  E V++ L++K   D    D LTALH         + KLLL   AN NA+    
Sbjct: 339 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 398

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
           +TPLH A     I ++++LV+YGA + A+   G  P  +      L+++   +   G + 
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGASP 457

Query: 195 EKIN-----EMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLL 249
           +  N      + +A     +  + C++  G  +D    +  T LHIA   G     +LLL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 250 DHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
            H    D    +G+ PLH +A  GQ+ +A +L+  GA+ S  T     P+
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 71/259 (27%), Positives = 119/259 (45%), Gaps = 8/259 (3%)

Query: 73  LEASLRNDAEEVRYFLKNKVSPDLCN-EDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + R+  ++V   L  + +P L   ++GL+ LH     +  E VK LL H A V+   
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY-- 189
            +  T LH AA CGH  + K+L+   A+  A   +G  P  +   +  + V+E  + Y  
Sbjct: 363 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 422

Query: 190 --QGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
             Q IT+  +  + VA     +  +  ++  G   D  + +G T LH+A   G +     
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE-- 305
           LL +G  VD +  +   PLH A+  G+ ++ +LL+ H A   A T+    P+ +   E  
Sbjct: 483 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 542

Query: 306 -EFKVLLLELKHKHDVIMK 323
            +   +LLE    H +  K
Sbjct: 543 VDVASVLLEAGAAHSLATK 561



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 71/271 (26%), Positives = 120/271 (44%), Gaps = 43/271 (15%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L    + D    +G+T LH         +VKLLL  G  ++AK  +  TPLH AA  GH 
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCE------------------DEPTLDVIET---- 185
            +V++L++ GA LLA   +G  P  +                    D+ TLD +      
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372

Query: 186 --CMAYQGITQEKINE--------------MRVAPEQQMIADIHCMIAAGQDLDWIDAQG 229
             C  Y+ +T+  +++              + +A ++  I  +  ++  G  +  I   G
Sbjct: 373 AHCGHYR-VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 230 ATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLS 289
            T +H+A   G+L    LLL +G   DV +  G   LH AA  GQ+++   L+ +GA + 
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 290 ARTSMDEMPIDLC----EEEEFKVLLLELKH 316
           AR   ++ P+ +     + E  ++LL  + H
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 5/264 (1%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           E    L  AS     E V+  L++   PD    +G T LH    +   ++  +LL  GA 
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC----EDEPTLDV 182
            +    + +TPLH AA  G +++ K+L+Q  A   +   +G  P  +       +  L +
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 615

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYL 242
           +E   +     +     + +A ++  +     ++  G + + +  QG T LH+A   G+ 
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675

Query: 243 RAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP-IDL 301
               LLLD G  + +    G   LH AA   ++ +A++L  HGA   A T +   P I  
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 735

Query: 302 CEEEEFKVLLLELKHKHDVIMKSQ 325
           C     K++   LK   +V  K++
Sbjct: 736 CHYGNVKMVNFLLKQGANVNAKTK 759



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 59/214 (27%), Positives = 99/214 (46%), Gaps = 6/214 (2%)

Query: 85  RYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATC 144
           +  L+ + + D   ++GLT LH     + +++  LLL  GA+ +A     +TPLH AA  
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639

Query: 145 GHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI-----TQEKINE 199
             + +   L+ YGA+   V   G  P  L   E   D++ T +  +G      T+  +  
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV-TLLLDKGANIHMSTKSGLTS 698

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           + +A ++  +     +   G D D     G T L +A   G ++    LL  G  V+ K 
Sbjct: 699 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 758

Query: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTS 293
            +G+ PLH AA  G   +  +L+ HGA  +A T+
Sbjct: 759 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 792



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 67/258 (25%), Positives = 107/258 (41%), Gaps = 5/258 (1%)

Query: 65  SFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHG 124
           +     AL  A+     E VR  L+N    D    +  T LH        EIV+LLL H 
Sbjct: 461 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520

Query: 125 ANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE 184
           A+ +A     +TPLH +A  G +++  +L++ GA        G  P  +     +LDV +
Sbjct: 521 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 580

Query: 185 TCM----AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG 240
             +    A     +  +  + VA           ++  G         G T LHIA    
Sbjct: 581 LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 640

Query: 241 YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
            ++ A  LL++G   ++    G  PLH A+  G   M  LL+  GA++   T      + 
Sbjct: 641 QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 700

Query: 301 LCEEEEFKVLLLELKHKH 318
           L  +E+ KV + ++  KH
Sbjct: 701 LAAQED-KVNVADILTKH 717



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 39/128 (30%), Positives = 63/128 (49%), Gaps = 1/128 (0%)

Query: 59  GRRKKVSFEASVALLEASLRNDAEEVRYFL-KNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           G    +S ++ +  L  + + D   V   L K+    D   + G T L   C     ++V
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
             LL  GANVNAK    +TPLH AA  GH +++ +L+Q+GA   A  ++GN    + +  
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 804

Query: 178 PTLDVIET 185
             + V++T
Sbjct: 805 GYISVVDT 812



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 48/210 (22%), Positives = 90/210 (42%), Gaps = 22/210 (10%)

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYL 242
           I TC       Q  +N + +A ++  +  +  ++  G  +D    +G T LHIA   G  
Sbjct: 57  INTC------NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 110

Query: 243 RAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLC 302
              ++L+  G  ++ +  +G+ PL+ AA    + + + L+ +GA+ S  T     P+ + 
Sbjct: 111 EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 170

Query: 303 EEE---EFKVLLLE--------LKHKHDVIMKSQLRHKSSLSRRTSSAGSRGK-VVRRAS 350
            ++   +   +LLE        L   H    K   +  + L +   +A  + K +V R +
Sbjct: 171 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 230

Query: 351 LSDRTNLYRKEYEGE----AILWQRSAAED 376
            S  T L+   + G      +L  R AA D
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAVD 260



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/82 (30%), Positives = 38/82 (46%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L+ A    + + V + LK   + +   ++G T LHQ        I+ +LL HGA  NA  
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791

Query: 132 NELWTPLHAAATCGHINLVKIL 153
               T L  A   G+I++V  L
Sbjct: 792 ANGNTALAIAKRLGYISVVDTL 813


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  100 bits (249), Expect = 4e-21
 Identities = 77/265 (29%), Positives = 122/265 (46%), Gaps = 12/265 (4%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           ++  AL  A+     + V   L++    +  + +G TAL         EIV+ LL HGA 
Sbjct: 643 DSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAE 702

Query: 127 VNAKDNELWTPLHAAATC-----GHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLD 181
           VN +D +  T L  AA C     GH ++V +L+  GA++   + DG  P  +   E  +D
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762

Query: 182 VIETCMAYQGITQEKINEMRV----APEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
           V++  +          N  R     A      + ++ ++  G  +D ID++G T+L IA 
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
           A G +     LLD G+  + +D  GW PLH AAF G   + E L+  GA  +   +   +
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882

Query: 298 PIDLCEEE---EFKVLLLELKHKHD 319
           P  L  +E   +   +LLE K   D
Sbjct: 883 PFILASQEGHYDCVQILLENKSNID 907



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 73/290 (25%), Positives = 135/290 (46%), Gaps = 21/290 (7%)

Query: 58   GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
            G R  ++  +  +  + AS     + V+  L+NK + D    DG  AL    ++   +IV
Sbjct: 870  GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIV 929

Query: 118  KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            +LL SHGA+VN KD +    L+  A    + + +  ++ GA++ A +++G     +   +
Sbjct: 930  ELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQ 989

Query: 178  PTLDVIETCMAYQGITQEKINEMRVAPE----QQMIADIHCMIAAGQDLDWIDAQGATLL 233
              +++++  +AY        NE R A +    Q  +  +  +I  G  +D    QGAT L
Sbjct: 990  GHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATAL 1049

Query: 234  HIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTS 293
             IA   G++   ++LL+HG   +  D  G   +  AA  G  Q+ +LL  +GA  S+   
Sbjct: 1050 CIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA--SSLNG 1107

Query: 294  MDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRG 343
                P+   E++  + L  +++               SL+ +++S+GS G
Sbjct: 1108 CSPSPVHTMEQKPLQSLSSKVQ---------------SLTIKSNSSGSTG 1142



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 61/226 (26%), Positives = 109/226 (48%), Gaps = 6/226 (2%)

Query: 71  ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAK 130
           AL   + +  A  V   +      D C++DG+T L     +   ++V LLL  GA+V+  
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777

Query: 131 DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQ 190
           DN   TPL AAA+ GH ++V  L+ +GA + +++S+G     +   +  ++V+ T +  +
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLD-R 836

Query: 191 GITQEKINEMRVAPEQQMIADIH-----CMIAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
           G+ +   ++    P      + H      +I  G   + ID  G     +A   G+    
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCV 896

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSAR 291
           ++LL++   +D + +DG   L  AA  G   + ELL SHGA ++ +
Sbjct: 897 QILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942



 Score = 76.6 bits (187), Expect = 6e-14
 Identities = 59/267 (22%), Positives = 117/267 (43%), Gaps = 5/267 (1%)

Query: 58   GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
            G     +  E    L  AS + + E VR  L   +  +  ++ G T LH    +    I 
Sbjct: 804  GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC 863

Query: 118  KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
            + L+  GA  N  DN+   P   A+  GH + V+IL++  +++     DG     +   E
Sbjct: 864  EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923

Query: 178  PTLDVIETCMAYQGITQEKINEMR----VAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
               D++E   ++      K  + R    +   +  +      +  G +++  DA+G T L
Sbjct: 924  GHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTAL 983

Query: 234  HIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTS 293
            H++   G++   ++L+ +   V+  D +    L +AA+ G +++ +LL+ HGA +    +
Sbjct: 984  HVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043

Query: 294  MDEMPIDLCEEE-EFKVLLLELKHKHD 319
                 + +  +E    V+ + L+H  D
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGAD 1070



 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 29/208 (13%)

Query: 82  EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
           + +R  L N  S + C+ +G T L         ++V LL+S GA++  +D    TPL  A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585

Query: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMR 201
           A  GH  +V  L+  GA++   + DG                    A+ G T+       
Sbjct: 586 ARQGHTKVVNCLIGCGANINHTDQDGWTAL-------------RSAAWGGHTEV------ 626

Query: 202 VAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWD 261
                     +  ++ AG  +D  DA   T L  A   G+      LL HG  V+  D +
Sbjct: 627 ----------VSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNE 676

Query: 262 GWEPLHAAAFWGQMQMAELLVSHGASLS 289
           G   L AAA+ G  ++ E L+ HGA ++
Sbjct: 677 GRTALIAAAYMGHREIVEHLLDHGAEVN 704



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 57/241 (23%), Positives = 98/241 (40%), Gaps = 17/241 (7%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  A+     + V   +      ++ +  G T L         ++V  L+  GAN+N  D
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTD 608

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQG 191
            + WT L +AA  GH  +V  L+  G  +   ++D              D++   + +  
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668

Query: 192 ITQEKINEMRVAPEQQMIAD--------IHCMIAAGQDLDWIDAQGATLLHIA-----GA 238
              +  NE R A    +IA         +  ++  G +++  D  G T L +A      +
Sbjct: 669 EVNKADNEGRTA----LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPAS 724

Query: 239 NGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP 298
            G+     LL+D G  VD  D DG  PL  AA+ G + + +LL+  GA +    +    P
Sbjct: 725 KGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTP 784

Query: 299 I 299
           +
Sbjct: 785 L 785



 Score = 69.3 bits (168), Expect = 9e-12
 Identities = 53/176 (30%), Positives = 80/176 (45%), Gaps = 29/176 (16%)

Query: 114 EEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL 173
           E+ ++ LL +GA+VN  D+   T L  AA  G +++V +LV  GADL   ++ G+ P  L
Sbjct: 525 EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 584

Query: 174 CEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
                         A QG T+                 ++C+I  G +++  D  G T L
Sbjct: 585 A-------------ARQGHTKV----------------VNCLIGCGANINHTDQDGWTAL 615

Query: 234 HIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLS 289
             A   G+      LL  GV+VD  D D    L AAA+ G   +   L+ HGA ++
Sbjct: 616 RSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 20/58 (34%), Positives = 29/58 (50%)

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE 305
           LLD+G  V+  D +G   L  AA+ G + +  LLVS GA L    +    P+ L   +
Sbjct: 531 LLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQ 588


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  100 bits (248), Expect = 5e-21
 Identities = 76/273 (27%), Positives = 122/273 (44%), Gaps = 21/273 (7%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           + + AL  ASL   AE V+  +K   + +  +++G T L+    +N  ++VK LL +GAN
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGAD---------LLAVNSDGNMPYDLCEDE 177
            +    + +TPL  A   GH   V IL++             + A   D      L +++
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 194

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
              DV ++ M     T+     + +A     +     ++  G  +D+    G T LH+A 
Sbjct: 195 HNADV-QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
             G     +LLLD G ++D K  DG  PLH AA  G  Q+ ELL+  GA L ART     
Sbjct: 254 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLS 313

Query: 298 PIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKS 330
           P+ +  + +           H   +K  L+HK+
Sbjct: 314 PLHMAAQGD-----------HVECVKHLLQHKA 335



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 70/226 (30%), Positives = 108/226 (47%), Gaps = 4/226 (1%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAAT 143
           V   L+N  SPD+ N  G TALH        E+V+ LL +GA V+A+  E  TPLH A+ 
Sbjct: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASR 485

Query: 144 CGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDV----IETCMAYQGITQEKINE 199
            G   +V++L+Q+ A   A  ++G  P  +   E  +DV    +E   A+   T++    
Sbjct: 486 LGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTP 545

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           + VA +   +     ++      D     G T LH+A      + A LLL+ G       
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605

Query: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE 305
            +G+ PLH AA   QMQ+A  L+++GA  +  T     P+ L  +E
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 651



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 66/230 (28%), Positives = 107/230 (46%), Gaps = 6/230 (2%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNEL 134
           A+  +  E V++ L++K   D    D LTALH         + KLLL   AN NA+    
Sbjct: 318 AAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNG 377

Query: 135 WTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ 194
           +TPLH A     I ++++LV+YGA + A+   G  P  +      L+++   +   G + 
Sbjct: 378 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIV-LLLLQNGASP 436

Query: 195 EKIN-----EMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLL 249
           +  N      + +A     +  + C++  G  +D    +  T LHIA   G     +LLL
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496

Query: 250 DHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
            H    D    +G+ PLH +A  GQ+ +A +L+  GA+ S  T     P+
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 546



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 71/259 (27%), Positives = 119/259 (45%), Gaps = 8/259 (3%)

Query: 73  LEASLRNDAEEVRYFLKNKVSPDLCN-EDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L  + R+  ++V   L  + +P L   ++GL+ LH     +  E VK LL H A V+   
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 341

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAY-- 189
            +  T LH AA CGH  + K+L+   A+  A   +G  P  +   +  + V+E  + Y  
Sbjct: 342 LDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGA 401

Query: 190 --QGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAEL 247
             Q IT+  +  + VA     +  +  ++  G   D  + +G T LH+A   G +     
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461

Query: 248 LLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE-- 305
           LL +G  VD +  +   PLH A+  G+ ++ +LL+ H A   A T+    P+ +   E  
Sbjct: 462 LLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQ 521

Query: 306 -EFKVLLLELKHKHDVIMK 323
            +   +LLE    H +  K
Sbjct: 522 VDVASVLLEAGAAHSLATK 540



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 71/271 (26%), Positives = 120/271 (44%), Gaps = 43/271 (15%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           L    + D    +G+T LH         +VKLLL  G  ++AK  +  TPLH AA  GH 
Sbjct: 232 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 291

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCE------------------DEPTLDVIET---- 185
            +V++L++ GA LLA   +G  P  +                    D+ TLD +      
Sbjct: 292 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 351

Query: 186 --CMAYQGITQEKINE--------------MRVAPEQQMIADIHCMIAAGQDLDWIDAQG 229
             C  Y+ +T+  +++              + +A ++  I  +  ++  G  +  I   G
Sbjct: 352 AHCGHYR-VTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410

Query: 230 ATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLS 289
            T +H+A   G+L    LLL +G   DV +  G   LH AA  GQ+++   L+ +GA + 
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470

Query: 290 ARTSMDEMPIDLC----EEEEFKVLLLELKH 316
           AR   ++ P+ +     + E  ++LL  + H
Sbjct: 471 ARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 66/264 (25%), Positives = 115/264 (43%), Gaps = 5/264 (1%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           E    L  AS     E V+  L++   PD    +G T LH    +   ++  +LL  GA 
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC----EDEPTLDV 182
            +    + +TPLH AA  G +++ K+L+Q  A   +   +G  P  +       +  L +
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLL 594

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYL 242
           +E   +     +     + +A ++  +     ++  G + + +  QG T LH+A   G+ 
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654

Query: 243 RAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMP-IDL 301
               LLLD G  + +    G   LH AA   ++ +A++L  HGA   A T +   P I  
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVA 714

Query: 302 CEEEEFKVLLLELKHKHDVIMKSQ 325
           C     K++   LK   +V  K++
Sbjct: 715 CHYGNVKMVNFLLKQGANVNAKTK 738



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 59/214 (27%), Positives = 99/214 (46%), Gaps = 6/214 (2%)

Query: 85  RYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATC 144
           +  L+ + + D   ++GLT LH     + +++  LLL  GA+ +A     +TPLH AA  
Sbjct: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618

Query: 145 GHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGI-----TQEKINE 199
             + +   L+ YGA+   V   G  P  L   E   D++ T +  +G      T+  +  
Sbjct: 619 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMV-TLLLDKGANIHMSTKSGLTS 677

Query: 200 MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKD 259
           + +A ++  +     +   G D D     G T L +A   G ++    LL  G  V+ K 
Sbjct: 678 LHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKT 737

Query: 260 WDGWEPLHAAAFWGQMQMAELLVSHGASLSARTS 293
            +G+ PLH AA  G   +  +L+ HGA  +A T+
Sbjct: 738 KNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTA 771



 Score = 87.4 bits (215), Expect = 3e-17
 Identities = 63/231 (27%), Positives = 112/231 (48%), Gaps = 10/231 (4%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           +++ + L A+   + ++V  +LK  +  + CN++GL ALH    +    +V+ LL  G++
Sbjct: 9   DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETC 186
           V++   +  T LH A+  G   +VK+LV+ GA++ A + +G  P  +   E  +DV++  
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 187 MAYQGITQEKINEMRVAPEQQMIADIHCM-IAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
           +   G  Q    E    P    +   H   +A   + D         LHIA      ++A
Sbjct: 129 LE-NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 187

Query: 246 ELLLDHGVRVDVKD--------WDGWEPLHAAAFWGQMQMAELLVSHGASL 288
            LLL +    DV+           G+ PLH AA +G + +A LL++ GA++
Sbjct: 188 ALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 67/258 (25%), Positives = 107/258 (41%), Gaps = 5/258 (1%)

Query: 65  SFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHG 124
           +     AL  A+     E VR  L+N    D    +  T LH        EIV+LLL H 
Sbjct: 440 NIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499

Query: 125 ANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIE 184
           A+ +A     +TPLH +A  G +++  +L++ GA        G  P  +     +LDV +
Sbjct: 500 AHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAK 559

Query: 185 TCM----AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANG 240
             +    A     +  +  + VA           ++  G         G T LHIA    
Sbjct: 560 LLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN 619

Query: 241 YLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPID 300
            ++ A  LL++G   ++    G  PLH A+  G   M  LL+  GA++   T      + 
Sbjct: 620 QMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLH 679

Query: 301 LCEEEEFKVLLLELKHKH 318
           L  +E+ KV + ++  KH
Sbjct: 680 LAAQED-KVNVADILTKH 696



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 39/128 (30%), Positives = 63/128 (49%), Gaps = 1/128 (0%)

Query: 59  GRRKKVSFEASVALLEASLRNDAEEVRYFL-KNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           G    +S ++ +  L  + + D   V   L K+    D   + G T L   C     ++V
Sbjct: 664 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 723

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
             LL  GANVNAK    +TPLH AA  GH +++ +L+Q+GA   A  ++GN    + +  
Sbjct: 724 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRL 783

Query: 178 PTLDVIET 185
             + V++T
Sbjct: 784 GYISVVDT 791



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 48/210 (22%), Positives = 90/210 (42%), Gaps = 22/210 (10%)

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYL 242
           I TC       Q  +N + +A ++  +  +  ++  G  +D    +G T LHIA   G  
Sbjct: 36  INTC------NQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89

Query: 243 RAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLC 302
              ++L+  G  ++ +  +G+ PL+ AA    + + + L+ +GA+ S  T     P+ + 
Sbjct: 90  EVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVA 149

Query: 303 EEE---EFKVLLLE--------LKHKHDVIMKSQLRHKSSLSRRTSSAGSRGK-VVRRAS 350
            ++   +   +LLE        L   H    K   +  + L +   +A  + K +V R +
Sbjct: 150 LQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTT 209

Query: 351 LSDRTNLYRKEYEGE----AILWQRSAAED 376
            S  T L+   + G      +L  R AA D
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAVD 239



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 25/90 (27%), Positives = 46/90 (51%)

Query: 216 IAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQM 275
           +  G D++  +  G   LH+A   G++   + LL  G  VD     G   LH A+  GQ 
Sbjct: 30  LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQA 89

Query: 276 QMAELLVSHGASLSARTSMDEMPIDLCEEE 305
           ++ ++LV  GA+++A++     P+ +  +E
Sbjct: 90  EVVKVLVKEGANINAQSQNGFTPLYMAAQE 119



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 25/82 (30%), Positives = 38/82 (46%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L+ A    + + V + LK   + +   ++G T LHQ        I+ +LL HGA  NA  
Sbjct: 711 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 770

Query: 132 NELWTPLHAAATCGHINLVKIL 153
               T L  A   G+I++V  L
Sbjct: 771 ANGNTALAIAKRLGYISVVDTL 792


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 67/244 (27%), Positives = 107/244 (43%), Gaps = 29/244 (11%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           G    +V  +    L  A+   D    R  L +    D    +G T LH    +NFE + 
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVA 477

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
           +LL+S  A+ N  + E  TPLH AA  GH++LVK+L   GA+L A   +   P       
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTP------- 530

Query: 178 PTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAG 237
                                 + +A E+  +  I  ++ +G   D +D  G   LH A 
Sbjct: 531 ----------------------LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA 568

Query: 238 ANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEM 297
           A G     ++LL +G  +++    GW PLH AA+ G +++  LL    A++ A  +++  
Sbjct: 569 ARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628

Query: 298 PIDL 301
           P+ L
Sbjct: 629 PLHL 632



 Score = 92.8 bits (229), Expect = 7e-19
 Identities = 67/228 (29%), Positives = 103/228 (45%), Gaps = 4/228 (1%)

Query: 78  RNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTP 137
           +   E+VR  L ++V  D     G T L     D   ++  LLL+HGA+ N  D + W P
Sbjct: 372 QGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 138 LHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQ--- 194
           LH AA  G     ++L+ +GA + A   +G  P  L       +V    ++ Q       
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 195 -EKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGV 253
            E    + VA     ++ +  + + G +LD       T LH+A   G +RA + LL  G 
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGA 551

Query: 254 RVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
             D  D  G+ PLH AA  G+  + ++L+ +GASL   T     P+ L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 54/224 (24%), Positives = 93/224 (41%), Gaps = 29/224 (12%)

Query: 78  RNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTP 137
           R     +++ LK+   PD  ++ G   LH         I K+LL +GA++    ++ WTP
Sbjct: 537 RGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTP 596

Query: 138 LHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKI 197
           LH AA  GH+ ++ +L +  A++ A+ +    P                           
Sbjct: 597 LHLAAYKGHLEIIHLLAESHANMGALGAVNWTP--------------------------- 629

Query: 198 NEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDV 257
             + +A      A +  ++  G D +  +  G T LH+A       +   LL+H   V  
Sbjct: 630 --LHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687

Query: 258 KDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
           ++  GW P H AA  G   + ++LV  GA L  +  +   P+ L
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 52/187 (27%), Positives = 76/187 (40%), Gaps = 35/187 (18%)

Query: 119 LLLSHGANVNAKDNELW------TPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYD 172
           L LS   N+  +D EL       TPLH     G +  V++L+ +  D+    + G  P  
Sbjct: 341 LQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTP-- 398

Query: 173 LCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATL 232
                                      + +A + Q       ++A G D + +D  G   
Sbjct: 399 ---------------------------LLIAAQDQQPDLCALLLAHGADANRVDEDGWAP 431

Query: 233 LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSART 292
           LH A  NG    A LLLDHG  VD ++ +GW PLH AA      +A LLVS  A  +   
Sbjct: 432 LHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE 491

Query: 293 SMDEMPI 299
           +  + P+
Sbjct: 492 AEGKTPL 498



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 37/117 (31%), Positives = 53/117 (45%)

Query: 192 ITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDH 251
           I + K+  +     Q  +  +  ++A   D+D   A G T L IA  +       LLL H
Sbjct: 358 IYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417

Query: 252 GVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFK 308
           G   +  D DGW PLH AA  G    A LL+ HGA + A+      P+ L  +  F+
Sbjct: 418 GADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFE 474


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 73/276 (26%), Positives = 126/276 (45%), Gaps = 10/276 (3%)

Query: 69  SVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVN 128
           S A+  A+     + +++  +NK   D+ ++ G  ALH        ++ +LL S G+N N
Sbjct: 413 SNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPN 472

Query: 129 AKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMA 188
            +D E  TPLH AA  G+ ++ K L + G ++   N +G  P          D++E C+A
Sbjct: 473 IQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVE-CLA 531

Query: 189 YQGITQEKINE-----MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLR 243
             G      ++     + +A  +  +  I  +++ G  +D+ D  G T LH+A  +G + 
Sbjct: 532 EHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMP 591

Query: 244 AAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCE 303
               L +    +D+ +  G  PLH AA  G + +   L   GAS+ A T+  +   DL  
Sbjct: 592 IVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLAR 651

Query: 304 EEEFK----VLLLELKHKHDVIMKSQLRHKSSLSRR 335
            E+ +    +L    K  H  +   QLR   +L  R
Sbjct: 652 SEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPR 687



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 54/218 (24%), Positives = 96/218 (44%), Gaps = 13/218 (5%)

Query: 105 LHQCCIDNFEEIVKLLLS-HGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAV 163
           +H    DN   +  LL S    +VN  +     PL  AA CG+I ++++L++ G+ +   
Sbjct: 349 IHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQ 408

Query: 164 NSDGNMPYDLCEDEPTLDVIETCMAYQG--ITQEKINEMRVAPEQQM----IADIHCMIA 217
           +  G+           +D ++     +     ++K  EM +    +     +A + C   
Sbjct: 409 DKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFG 468

Query: 218 AGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQM 277
           +  ++   D +  T LH A  +GY   A+ L + G  V++K+ +G  PL  A+  G   +
Sbjct: 469 SNPNIQ--DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDI 526

Query: 278 AELLVSHGASLSARTSMDEMPIDL----CEEEEFKVLL 311
            E L  HGA L+A      + + L    C+ E  K LL
Sbjct: 527 VECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL 564



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 37/117 (31%), Positives = 54/117 (46%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           E    LL AS R   + V    ++    + C++DG  ALH        E++K LLS G  
Sbjct: 510 EGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCF 569

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVI 183
           V+ +D    TPLH A   G++ +V  L +   +L   N  G  P  L  +   LDV+
Sbjct: 570 VDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVV 626



 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 34/111 (30%), Positives = 49/111 (44%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           +  +AL  A  R   E ++  L      D  +  G T LH  C D    IV  L     N
Sbjct: 543 DGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCN 602

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDE 177
           ++  +    TPLH AA  G +++V+ L   GA + A+ +DG    DL   E
Sbjct: 603 LDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSE 653


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score = 93.2 bits (230), Expect = 6e-19
 Identities = 76/282 (26%), Positives = 121/282 (42%), Gaps = 22/282 (7%)

Query: 62  KKVSFEAS-----VALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEI 116
           +K+S  A       AL  A+   D    R  L+   S +  + +G T +H  C    E I
Sbjct: 493 RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENI 552

Query: 117 VKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILV-QYGADLLAVNSDGNMPYDLCE 175
           V++LL  G +V+ +  + W PLH AA  GH+ +VK+L  Q G  + A   DG  P  L  
Sbjct: 553 VRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAA 612

Query: 176 DEPTLDV----IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGAT 231
                 V    I+ C      +      + VA E    +    ++  G   + + + G T
Sbjct: 613 QRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYT 672

Query: 232 LLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSAR 291
            LH+A  NG+L   +LL++    V  +       LH AA  G  ++ E LVS        
Sbjct: 673 ALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADV----- 727

Query: 292 TSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLS 333
                  IDL +E+    L L  + +H   +++ LRH + ++
Sbjct: 728 -------IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 79/306 (25%), Positives = 135/306 (44%), Gaps = 12/306 (3%)

Query: 64  VSFEASVALLEASLRNDAEE-VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLS 122
           ++ ++  +LL  ++    EE  ++ L N  +P+L N  G T LH         +V+LLL+
Sbjct: 433 LALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLA 492

Query: 123 HGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDV 182
              +VNAKD + WT LH AA  G  +  ++L++  A +  V+ +G  P  +       ++
Sbjct: 493 RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENI 552

Query: 183 IETCMAYQGITQEKINEMRVAPEQQMIADIHCMIA---AGQDLDWIDAQ---GATLLHIA 236
           +   +  +G+      +    P        H  I    A Q    ++AQ   G T LH+A
Sbjct: 553 VRILLR-RGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 611

Query: 237 GANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDE 296
              G+ R A +L+D    V+V       PLH AA  G    A LL+  GA   A TS   
Sbjct: 612 AQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGY 671

Query: 297 MPIDLCEEE-EFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRT 355
             + L         + L ++ K DV+ +  L   +  +   ++A    +VV     +D  
Sbjct: 672 TALHLAARNGHLATVKLLVEEKADVLARGPL---NQTALHLAAAHGHSEVVEELVSADVI 728

Query: 356 NLYRKE 361
           +L+ ++
Sbjct: 729 DLFDEQ 734



 Score = 34.7 bits (78), Expect = 0.24
 Identities = 23/72 (31%), Positives = 37/72 (51%)

Query: 220 QDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAE 279
           QD+D     GA+LLH+A   G    A+ LL +    ++ +  G  PLH A       + E
Sbjct: 429 QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVE 488

Query: 280 LLVSHGASLSAR 291
           LL++   S++A+
Sbjct: 489 LLLARKISVNAK 500


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 60/229 (26%), Positives = 115/229 (50%), Gaps = 7/229 (3%)

Query: 93  SPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKI 152
           S ++ +  G TALH   ++   E+V LLL+ GAN+NA D +    LH AA  GH+++V +
Sbjct: 107 SVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL 166

Query: 153 LVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKIN-----EMRVAPEQQ 207
           L+ +GA++   +  G  P         ++V++  +   G+  ++IN      + +A    
Sbjct: 167 LINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNL-GVEIDEINVYGNTALHIACYNG 225

Query: 208 MIADIHCMIAAGQDLDWIDAQGATLLHIAGANGY-LRAAELLLDHGVRVDVKDWDGWEPL 266
             A ++ +I  G +++  +  G T LH A A+ +     ELL+++G  V+++  DG  PL
Sbjct: 226 QDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPL 285

Query: 267 HAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELK 315
           H  A  G+   ++ L+ +G  +         P+ +      ++L+  L+
Sbjct: 286 HMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334



 Score = 89.4 bits (220), Expect = 8e-18
 Identities = 64/222 (28%), Positives = 100/222 (45%), Gaps = 7/222 (3%)

Query: 71  ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAK 130
           AL  A+L    E V   L    + +  ++    ALH        ++V LL++HGA V  K
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177

Query: 131 DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQ 190
           D + +TPLHAAA+ G IN+VK L+  G ++  +N  GN    +        V+   + Y 
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY- 236

Query: 191 GITQEKINEMRVAPEQQMIADIH------CMIAAGQDLDWIDAQGATLLHIAGANGYLRA 244
           G    + N     P     A  H       ++  G D++     G + LH+   +G    
Sbjct: 237 GANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296

Query: 245 AELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGA 286
           ++ L+ +G  +D  D DG  PLH AA +G   +   L + GA
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 55/190 (28%), Positives = 88/190 (46%), Gaps = 4/190 (2%)

Query: 103 TALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLA 162
           T LH        EI++LL+  GA VNAKDN   TPLH A        V++L+++ AD+ A
Sbjct: 18  TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNA 77

Query: 163 VNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQM----IADIHCMIAA 218
            + +   P  +      +   E  +             R A         +  ++ ++A 
Sbjct: 78  RDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAK 137

Query: 219 GQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMA 278
           G +++  D +    LH A   G+L    LL++HG  V  KD  G+ PLHAAA  GQ+ + 
Sbjct: 138 GANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVV 197

Query: 279 ELLVSHGASL 288
           + L++ G  +
Sbjct: 198 KHLLNLGVEI 207



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 72/278 (25%), Positives = 115/278 (41%), Gaps = 48/278 (17%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           E    L  A+   DAE +   + +    +  +   LT LH+      EE V++L+ H A+
Sbjct: 15  EKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSAD 74

Query: 127 VNAKDNELWTPLHAAAT-----C----------------------------GHINLVKIL 153
           VNA+D    TPLH AA      C                            GH+ +V +L
Sbjct: 75  VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134

Query: 154 VQYGADLLAVNSDGNMPYDLCEDEPTLDVIE---------TCMAYQGITQEKINEMRVAP 204
           +  GA++ A +               LDV+          TC   +G T      +  A 
Sbjct: 135 LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYT-----PLHAAA 189

Query: 205 EQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWE 264
               I  +  ++  G ++D I+  G T LHIA  NG       L+D+G  V+  + +G+ 
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249

Query: 265 PLH-AAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
           PLH AAA        ELLV++GA ++ ++   + P+ +
Sbjct: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHM 287



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 65/252 (25%), Positives = 106/252 (42%), Gaps = 9/252 (3%)

Query: 55  RSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFE 114
           R++G    K    +   L  A+L   ++  R  L +    D  ++ G T LH        
Sbjct: 334 RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNV 393

Query: 115 EIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGN--MPYD 172
           E +KLL S GA+ + KD    TPLH AA   H + ++ LV  GA++   +  G   + Y 
Sbjct: 394 ECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453

Query: 173 LCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATL 232
              D   +D  +T +       E++   R   E++    +  ++    +    D +G   
Sbjct: 454 AASD---MDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNS 510

Query: 233 LHIAGANGYLRAAELLLDHGVRVDVKDWDGW---EPLHAAAFWGQMQMAELLVSHGASLS 289
           +H A A G+ +  ELLL+       ++ D      PLH AA+ G  Q  E+L+     L 
Sbjct: 511 IHYAAAYGHRQCLELLLER-TNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD 569

Query: 290 ARTSMDEMPIDL 301
            R       +DL
Sbjct: 570 IRDEKGRTALDL 581



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 56/241 (23%), Positives = 100/241 (41%), Gaps = 10/241 (4%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLL--SHGANVNAKDNELWTPLHAA 141
           + + L+N  +P + +++G  ++H        + ++LLL  ++     +      +PLH A
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549

Query: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMR 201
           A  GH   +++L+Q   DL   +  G    DL   +   + +E  +        K N  +
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609

Query: 202 VAPEQQMIADIHCM-------IAAGQD-LDWIDAQGATLLHIAGANGYLRAAELLLDHGV 253
             P    + + H +       IA   + +D  DA+G T L +A A G++ A  LLL+   
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669

Query: 254 RVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLE 313
            VD  D  G   LH     G  +  ++L+    S+  + S    P+           L E
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729

Query: 314 L 314
           L
Sbjct: 730 L 730



 Score = 59.3 bits (142), Expect = 9e-09
 Identities = 51/202 (25%), Positives = 78/202 (38%), Gaps = 29/202 (14%)

Query: 88  LKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHI 147
           + N    ++ ++DG + LH   +       + L+ +G  ++  D +  TPLH AA  GH 
Sbjct: 268 VNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHE 327

Query: 148 NLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQ 207
            L+  L   GAD          P  L      L+    C                     
Sbjct: 328 LLINTLRTSGADTAKCGIHSMFPLHLA----ALNAHSDC--------------------- 362

Query: 208 MIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLH 267
                  ++++G ++D  D  G T LH A A G +   +LL   G     KD  G  PLH
Sbjct: 363 ----CRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLH 418

Query: 268 AAAFWGQMQMAELLVSHGASLS 289
            AA        E LV+ GA+++
Sbjct: 419 YAAANCHFHCIETLVTTGANVN 440



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 57/230 (24%), Positives = 99/230 (43%), Gaps = 28/230 (12%)

Query: 54  KRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNF 113
           +R+  G  +  S      L  A+     + +   L++ V  D+ +E G TAL        
Sbjct: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGH 587

Query: 114 EEIVKLLLSHGANVNAKDN-ELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYD 172
            E V+ L++ GA++  KDN    TPLHA+   GH   +++L+                 +
Sbjct: 588 TECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLL-----------------E 630

Query: 173 LCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATL 232
           + ++   +DV +     +G T      + +A     I  +  ++    ++D +D  G T 
Sbjct: 631 IADNPEAVDVKDA----KGQT-----PLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTA 681

Query: 233 LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQ-MAELL 281
           LH     G+    ++LL+  V +  KD  G  PLH AA  G    ++ELL
Sbjct: 682 LHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELL 731



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 62/248 (25%), Positives = 99/248 (39%), Gaps = 10/248 (4%)

Query: 82  EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
           + V   L+ + + D  +  G TALH+  +   EE V++LL    ++  KD+   TPLH A
Sbjct: 659 DAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718

Query: 142 ATCGHINLVKILVQYG---ADLLAVNSDGNMPYDLC---EDEPTLDVIETCMAYQGITQE 195
           A  GH   +  L+Q      D    ++ G  P        +E  ++V+     ++     
Sbjct: 719 AARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778

Query: 196 KINEMRVA--PEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGV 253
               +  A   +    A +         +   D +G T L  A    ++   +LLL H  
Sbjct: 779 PFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838

Query: 254 RVDVKDWDGWEPLHAAAFWGQMQMAELLV-SHGASLSARTSMDEMPIDL-CEEEEFKVLL 311
            V+  D  G   L  AA  GQ    ++LV S  A L+ +      P+ L C +   K  L
Sbjct: 839 PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCAL 898

Query: 312 LELKHKHD 319
           L L    D
Sbjct: 899 LILDKIQD 906



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 55/229 (24%), Positives = 94/229 (41%), Gaps = 25/229 (10%)

Query: 71  ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDN----FEEIVKLLLSHGAN 126
           AL    +    E V+  L+ +VS    +  G T LH            E++++ LS   +
Sbjct: 681 ALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE-ED 739

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGA------------DLLAVNSDGNMPYDLC 174
              KDN+ +TPLH A   G+ N +++L++                   +N  GN    L 
Sbjct: 740 CCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLL 799

Query: 175 EDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLH 234
               +   I +C   +G T      +R A     +  +  ++     ++ +D  G T L 
Sbjct: 800 GAIDS--SIVSCRDDKGRT-----PLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALM 852

Query: 235 IAGANGYLRAAELLLDHG-VRVDVKDWDGWEPLHAAAFWGQMQMAELLV 282
           +A  NG   A ++L++     + VKD D   PLH A   G  + A L++
Sbjct: 853 MAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLIL 901



 Score = 35.0 bits (79), Expect = 0.18
 Identities = 24/98 (24%), Positives = 44/98 (44%), Gaps = 1/98 (1%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHG-ANVNAK 130
           L  A+  +  E ++  L++    +  +  G TAL     +     V +L++   A++  K
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVK 877

Query: 131 DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGN 168
           D +L TPLH A + GH     +++    D   +N   N
Sbjct: 878 DKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKNN 915


>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 62/206 (30%), Positives = 96/206 (46%), Gaps = 29/206 (14%)

Query: 98  NEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYG 157
           ++D  TALH  C     EIV+ LL  G  VN KD+  W+PLH AA+ G   +VK L+  G
Sbjct: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96

Query: 158 ADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIA 217
           A + AVN +G                  C        +  +E+ V            ++ 
Sbjct: 97  AQVNAVNQNG------------------CTPLHYAASKNRHEIAVM-----------LLE 127

Query: 218 AGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQM 277
            G + D  D   AT +H A A G L+   +LL +    +++D +G  PLH A    +++ 
Sbjct: 128 GGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE 187

Query: 278 AELLVSHGASLSARTSMDEMPIDLCE 303
           A+LLVS GAS+      ++ P+ + +
Sbjct: 188 AKLLVSQGASIYIENKEEKTPLQVAK 213



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 34/100 (34%), Positives = 52/100 (52%)

Query: 82  EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
           E V+  L      +  N++G T LH     N  EI  +LL  GAN +AKD+   T +H A
Sbjct: 87  EIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146

Query: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLD 181
           A  G++ ++ IL+ Y A     +++GN P  L  DE  ++
Sbjct: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVE 186



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 42/193 (21%), Positives = 79/193 (40%), Gaps = 30/193 (15%)

Query: 114 EEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDL 173
           EE+ + +L+  +     D +  T LH A + GH  +V+ L+Q G  +   +  G  P  +
Sbjct: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79

Query: 174 CEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLL 233
                  ++++                              ++  G  ++ ++  G T L
Sbjct: 80  AASAGRDEIVKA-----------------------------LLGKGAQVNAVNQNGCTPL 110

Query: 234 HIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTS 293
           H A +      A +LL+ G   D KD      +H AA  G ++M  +L+ + AS + + +
Sbjct: 111 HYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT 170

Query: 294 MDEMPIDL-CEEE 305
               P+ L C+EE
Sbjct: 171 EGNTPLHLACDEE 183



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 50/203 (24%), Positives = 81/203 (39%), Gaps = 29/203 (14%)

Query: 67  EASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
           ++  AL  A      E V + L+  V  +  ++ G + LH       +EIVK LL  GA 
Sbjct: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98

Query: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETC 186
           VNA +    TPLH AA+     +  +L++ GA     N D    Y+              
Sbjct: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA-----NPDAKDHYE-------------- 139

Query: 187 MAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAE 246
                        M  A  +  +  IH ++      +  D +G T LH+A     +  A+
Sbjct: 140 ----------ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189

Query: 247 LLLDHGVRVDVKDWDGWEPLHAA 269
           LL+  G  + +++ +   PL  A
Sbjct: 190 LLVSQGASIYIENKEEKTPLQVA 212



 Score = 46.2 bits (108), Expect = 8e-05
 Identities = 30/118 (25%), Positives = 52/118 (44%)

Query: 58  GGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIV 117
           G +   V+      L  A+ +N  E     L+   +PD  +    TA+H+       +++
Sbjct: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155

Query: 118 KLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCE 175
            +LL + A+ N +D E  TPLH A     +   K+LV  GA +   N +   P  + +
Sbjct: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213


>gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Homo
            sapiens]
          Length = 1134

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 50/132 (37%), Positives = 71/132 (53%), Gaps = 5/132 (3%)

Query: 50   KHERKRSTGGRR----KKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTAL 105
            K    R TG  R     +V F     LL++SL  + + V+  +     P L N++G+TAL
Sbjct: 910  KRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITAL 969

Query: 106  HQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVN- 164
            H        EIVK L+  G NVNA D++ WTPLH AA+C ++ + K LV+ GA + A+  
Sbjct: 970  HNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTY 1029

Query: 165  SDGNMPYDLCED 176
            SD     D CE+
Sbjct: 1030 SDMQTAADKCEE 1041



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 32/80 (40%), Positives = 43/80 (53%), Gaps = 1/80 (1%)

Query: 228  QGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287
            +G T LH A   G+    + L+  GV V+  D DGW PLH AA    +Q+ + LV  GA+
Sbjct: 964  EGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAA 1023

Query: 288  LSARTSMD-EMPIDLCEEEE 306
            + A T  D +   D CEE E
Sbjct: 1024 VFAMTYSDMQTAADKCEEME 1043


>gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo
           sapiens]
          Length = 1005

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 50/132 (37%), Positives = 71/132 (53%), Gaps = 5/132 (3%)

Query: 50  KHERKRSTGGRR----KKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTAL 105
           K    R TG  R     +V F     LL++SL  + + V+  +     P L N++G+TAL
Sbjct: 781 KRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGEFDLVQRIIYEVDDPSLPNDEGITAL 840

Query: 106 HQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVN- 164
           H        EIVK L+  G NVNA D++ WTPLH AA+C ++ + K LV+ GA + A+  
Sbjct: 841 HNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMTY 900

Query: 165 SDGNMPYDLCED 176
           SD     D CE+
Sbjct: 901 SDMQTAADKCEE 912



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 32/80 (40%), Positives = 43/80 (53%), Gaps = 1/80 (1%)

Query: 228 QGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287
           +G T LH A   G+    + L+  GV V+  D DGW PLH AA    +Q+ + LV  GA+
Sbjct: 835 EGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAA 894

Query: 288 LSARTSMD-EMPIDLCEEEE 306
           + A T  D +   D CEE E
Sbjct: 895 VFAMTYSDMQTAADKCEEME 914


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 61/236 (25%), Positives = 110/236 (46%), Gaps = 5/236 (2%)

Query: 71  ALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAK 130
           AL  A      E V   L    S ++C++     LH        E++KLL++ GA++  K
Sbjct: 143 ALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK 202

Query: 131 DNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLC----EDEPTLDVIETC 186
           D + +  LH AA  G I +VK L++ GA++   N+ GN    +     +D   ++++   
Sbjct: 203 DRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAG 262

Query: 187 MAYQGITQEKINEMRVAPEQQMIA-DIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAA 245
                   +    + VA      A  +  ++  G D+++   +G + LH+A  +G    +
Sbjct: 263 ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRS 322

Query: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
           ++L+ +G  +D  D  G  PLH AA +G   +   L+++GA  + R   D  P+ L
Sbjct: 323 QILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHL 378



 Score = 86.7 bits (213), Expect = 5e-17
 Identities = 64/220 (29%), Positives = 99/220 (45%), Gaps = 29/220 (13%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L++A    D EEVR  L  K + ++ +++  T LH         I++LLL  GANVNAKD
Sbjct: 12  LVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD 71

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQG 191
               TPLH AA   +  ++ +L+ + AD+ A +     P                     
Sbjct: 72  TLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTP--------------------- 110

Query: 192 ITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDH 251
                   + VA   +       +      L+  D  G + LH A  +G+L    LLL+ 
Sbjct: 111 --------LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNK 162

Query: 252 GVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSAR 291
           G  ++V D    +PLH AAF G +++ +LLV+ GA L  +
Sbjct: 163 GASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK 202



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 60/228 (26%), Positives = 107/228 (46%), Gaps = 7/228 (3%)

Query: 93  SPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKI 152
           S ++ +  G +ALH        E V LLL+ GA++N  D +   PLH AA  GH+ ++K+
Sbjct: 132 SLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKL 191

Query: 153 LVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKI----NEMRVAPEQQM 208
           LV  GADL   +  G            ++V++  +       E        + +A     
Sbjct: 192 LVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251

Query: 209 IADIHCMIAAGQDLDWIDAQGATLLHIAGA--NGYLRAAELLLDHGVRVDVKDWDGWEPL 266
            A    ++ AG +++  + +G T LH+A    NG L   ELL+++G  V+ +  +G  PL
Sbjct: 252 DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPL 310

Query: 267 HAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLEL 314
           H AA  G+   +++L+ +G+ +         P+ +      ++L+  L
Sbjct: 311 HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 61/215 (28%), Positives = 99/215 (46%), Gaps = 23/215 (10%)

Query: 98  NEDGLTALHQCCID-NFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQY 156
           N+ G T LH   +  N    ++LL+++GA+VN +  E  +PLH AA  G     +IL+Q 
Sbjct: 269 NDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQN 328

Query: 157 GADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEK-INEM--------------- 200
           G+++   +  GN P  +        +I T M     T  + I++M               
Sbjct: 329 GSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCC 388

Query: 201 -RVAPEQQMIADIHCM-----IAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVR 254
            ++    Q+ + +  +     ++AG D++  D  G T LH A + G +    LLL  G  
Sbjct: 389 RKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGAD 448

Query: 255 VDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLS 289
           +  +D  G  PLH AA  G  Q A  LV+ GA ++
Sbjct: 449 LRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 60/222 (27%), Positives = 97/222 (43%), Gaps = 12/222 (5%)

Query: 75  ASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNE- 133
           A+     E ++   +  V+ D+ +  G TAL         E V++L +HGA+   K+ + 
Sbjct: 592 AAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651

Query: 134 LWTPLHAAATCGHINLVKILVQYG--ADLLAV-NSDGNMPYDLCEDEPTLDVIETCMAYQ 190
            WTPLHAAA  GH + + +L+  G  AD+  V ++ G  P  L      +D +   +   
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711

Query: 191 GITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWI----DAQGATLLHIAGANGYLRAAE 246
                     R A  +  +      +AA  D D      D +G T +H+A A G+     
Sbjct: 712 STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLR 771

Query: 247 LLLDHGVRVDV----KDWDGWEPLHAAAFWGQMQMAELLVSH 284
            LL   +  D      D+ G+ P+H A++ G     ELL+ H
Sbjct: 772 TLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 59/228 (25%), Positives = 91/228 (39%), Gaps = 10/228 (4%)

Query: 84  VRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANV--NAKDNELWTPLHAA 141
           + + L N   P L +  G TA+H        + ++LLL    N   + +     +PLH A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592

Query: 142 ATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMR 201
           A  GH   +K L +   +L   +  G     L  +  + + +E   A+      K  + +
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652

Query: 202 VAPEQQMIAD-----IHCMIAAGQDLDW---IDAQGATLLHIAGANGYLRAAELLLDHGV 253
             P     A      +H +I +G+  D    +DA G T L +A  NG++    LLL+ G 
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712

Query: 254 RVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDL 301
             D  D  G   LH  A  G       L+ H A +  R      PI L
Sbjct: 713 TADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 760



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 70/274 (25%), Positives = 109/274 (39%), Gaps = 37/274 (13%)

Query: 23  LRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLE-ASLRNDA 81
           L    K+  Q L  WA +   L+  K    R    G + +K        LL  A+     
Sbjct: 166 LNVCDKKERQPLH-WAAFLGHLEVLKLLVARGADLGCKDRK-----GYGLLHTAAASGQI 219

Query: 82  EEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAA 141
           E V+Y L+     D  N  G TALH  C    + +   L++ GANVN  +++ +TPLH A
Sbjct: 220 EVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVA 279

Query: 142 ATCGHINL-VKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEM 200
           A   +  L +++LV  GAD+   + +G  P            +     +   T+ +I   
Sbjct: 280 AVSTNGALCLELLVNNGADVNYQSKEGKSP------------LHMAAIHGRFTRSQI--- 324

Query: 201 RVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDW 260
                         +I  G ++D  D  G T LH+A   G+      L+ +G     +  
Sbjct: 325 --------------LIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGI 370

Query: 261 DGWEPLHAAAFWGQMQMAELLVSHGASLSARTSM 294
               PLH A  +G       L+S G   S  +S+
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSL 404



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 65/269 (24%), Positives = 103/269 (38%), Gaps = 29/269 (10%)

Query: 72  LLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKD 131
           L+ A +    + V   L+   + D  +  G TALH+  +   E+ +  LL H A V  +D
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751

Query: 132 NELWTPLHAAATCGHINLVKILVQYGADL----LAVNSDGNMPYDLCEDEPTLDVIETCM 187
            +  TP+H A+ CGH  +++ L+Q           V+  G  P          D +E  +
Sbjct: 752 FKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLL 811

Query: 188 AYQGITQEKINEMRVAPEQQMIADIHCMIAAGQD--------------LDWIDAQGATLL 233
            +   +  + N             +HC +   QD              ++  DA+G T L
Sbjct: 812 EHSPFSYLEGNP---------FTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPL 862

Query: 234 HIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHG-ASLSART 292
           H A     +    +LL H   V+  D  G   L  AA  GQ    E L+  G A L+   
Sbjct: 863 HAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLD 922

Query: 293 SMDEMPIDL-CEEEEFKVLLLELKHKHDV 320
                 + L C +   K  L+ L    D+
Sbjct: 923 ENKNTALHLACSKGHEKCALMILAETQDL 951



 Score = 59.7 bits (143), Expect = 7e-09
 Identities = 52/179 (29%), Positives = 85/179 (47%), Gaps = 12/179 (6%)

Query: 103  TALHQCCIDNFEEIVKLLLSH-GAN-VNAKDNELWTPLHAAATCGHINLVKILVQYGADL 160
            T LH   I+N +   ++LL   GA  VN++D +  TPLHAAA   +++ +++L+Q+ A++
Sbjct: 825  TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884

Query: 161  LAVNSDGNMPYDLCEDEPTLDVIETCMAYQG------ITQEKINEMRVAPEQQMIADIHC 214
             A +  G        +      +E  + Y+G      + + K   + +A  +        
Sbjct: 885  NATDHTGRTALMTAAENGQTAAVEFLL-YRGKADLTVLDENKNTALHLACSKGHEKCALM 943

Query: 215  MIAAGQDLDWIDAQGATL---LHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAA 270
            ++A  QDL  I+A  + L   LHIA  NG     + LL HG  V   D +G  P  A A
Sbjct: 944  ILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 55/223 (24%), Positives = 85/223 (38%), Gaps = 22/223 (9%)

Query: 79  NDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPL 138
           N A  +   + N    +  +++G + LH   I       ++L+ +G+ ++  D    TPL
Sbjct: 284 NGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPL 343

Query: 139 HAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMA---YQGITQE 195
           H AA  GH  L+  L+  GAD          P  L       D     ++      I   
Sbjct: 344 HVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSS 403

Query: 196 KINE-------------------MRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIA 236
             NE                   +  A     +  ++ ++++G DL   D  G T LH A
Sbjct: 404 LSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463

Query: 237 GANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAE 279
            ANG  + A  L+  G  V+  D  G  PLH AA     + AE
Sbjct: 464 AANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 38/122 (31%), Positives = 64/122 (52%), Gaps = 7/122 (5%)

Query: 71   ALLEASLRNDAEEVRYFL-KNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN--- 126
            AL+ A+       V + L + K    + +E+  TALH  C    E+   ++L+   +   
Sbjct: 894  ALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL 953

Query: 127  VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETC 186
            +NA ++ L  PLH AA  G  ++V+ L+ +GA +LAV+ +G+ P   C   P  DV + C
Sbjct: 954  INATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALAC--APNKDVAD-C 1010

Query: 187  MA 188
            +A
Sbjct: 1011 LA 1012



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 25/91 (27%), Positives = 49/91 (53%)

Query: 209 IADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHA 268
           + ++  +++  ++++ +D +  T LH A   G +   +LLL  G  V+ KD     PLH 
Sbjct: 21  VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHR 80

Query: 269 AAFWGQMQMAELLVSHGASLSARTSMDEMPI 299
           AA     ++  LL++H A ++AR  + + P+
Sbjct: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPL 111


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,757,025
Number of Sequences: 37866
Number of extensions: 972496
Number of successful extensions: 7428
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 348
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 3656
Number of HSP's gapped (non-prelim): 2104
length of query: 567
length of database: 18,247,518
effective HSP length: 108
effective length of query: 459
effective length of database: 14,157,990
effective search space: 6498517410
effective search space used: 6498517410
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.