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Search of human proteins with 28565285
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo
sapiens]
(396 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 816 0.0
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 721 0.0
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 339 3e-93
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 339 3e-93
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 271 6e-73
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 271 6e-73
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 271 6e-73
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 199 5e-51
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 169 5e-42
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 166 4e-41
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 164 2e-40
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 158 7e-39
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 158 7e-39
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 158 9e-39
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 154 1e-37
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 154 2e-37
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 153 2e-37
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 152 5e-37
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 152 5e-37
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 136 3e-32
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 133 2e-31
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 133 2e-31
gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 131 9e-31
gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1 ... 131 1e-30
gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 131 1e-30
gi|113415488 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 131 1e-30
gi|113415486 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 131 1e-30
gi|113415484 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 131 1e-30
gi|113415482 PREDICTED: Ubiquitin carboxyl-terminal hydrolase 17... 131 1e-30
gi|113415480 PREDICTED: similar to deubiquitinating enzyme 1 [Ho... 131 1e-30
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 816 bits (2107), Expect = 0.0
Identities = 396/396 (100%), Positives = 396/396 (100%)
Query: 1 MRTSYTVTLPEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGL 60
MRTSYTVTLPEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGL
Sbjct: 1 MRTSYTVTLPEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGL 60
Query: 61 RNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSS 120
RNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSS
Sbjct: 61 RNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSS 120
Query: 121 PNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDH 180
PNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDH
Sbjct: 121 PNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDH 180
Query: 181 LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRG 240
LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRG
Sbjct: 181 LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRG 240
Query: 241 YPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESR 300
YPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESR
Sbjct: 241 YPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESR 300
Query: 301 IRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGE 360
IRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGE
Sbjct: 301 IRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGE 360
Query: 361 WHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM 396
WHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
Sbjct: 361 WHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM 396
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 721 bits (1861), Expect = 0.0
Identities = 347/347 (100%), Positives = 347/347 (100%)
Query: 50 NSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEF 109
NSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEF
Sbjct: 259 NSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEF 318
Query: 110 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 169
AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL
Sbjct: 319 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 378
Query: 170 RPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPF 229
RPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPF
Sbjct: 379 RPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPF 438
Query: 230 WDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKIL 289
WDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKIL
Sbjct: 439 WDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKIL 498
Query: 290 VLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHY 349
VLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHY
Sbjct: 499 VLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVSNHSGTTMGGHY 558
Query: 350 TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM 396
TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM
Sbjct: 559 TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSRM 605
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 339 bits (869), Expect = 3e-93
Identities = 177/357 (49%), Positives = 233/357 (65%), Gaps = 20/357 (5%)
Query: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 115
G GLRNLGNTCF+N++LQCLS+TR LRD+CL+R + +++ G A L E FA +I
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE-LTEAFADVIGA 268
Query: 116 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNR--------- 166
+W + V+P+ F+ Q+Y P F GY+QQDAQEFL+ L++ LH E+NR
Sbjct: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
Query: 167 ----VTLRPKSNPENLDH--LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCG 220
V P+ L+ L DD++ MW++YLEREDS+I DLFVGQLKS L C CG
Sbjct: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
Query: 221 YCSTVFDPFWDLSLPIAKRGYP--EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIK 278
Y ST F+ F DLSLPI K+G+ +V+L DC LFTKE+ L+ + P C RCR + R K
Sbjct: 389 YRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTK 448
Query: 279 KFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVS 338
K ++QRFP+ILVLHL RFS SR K + V+FPL+ L L +FAS+ VY LYA+
Sbjct: 449 KLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALC 508
Query: 339 NHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSR 395
NHSG+ GHYTA CR TG WH +NDS V+P+S +QV +S+ Y+LFY+L P R
Sbjct: 509 NHSGSVHYGHYTALCRCQ-TG-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPR 563
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 339 bits (869), Expect = 3e-93
Identities = 177/357 (49%), Positives = 233/357 (65%), Gaps = 20/357 (5%)
Query: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 115
G GLRNLGNTCF+N++LQCLS+TR LRD+CL+R + +++ G A L E FA +I
Sbjct: 210 GHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQE-LTEAFADVIGA 268
Query: 116 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNR--------- 166
+W + V+P+ F+ Q+Y P F GY+QQDAQEFL+ L++ LH E+NR
Sbjct: 269 LWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPIL 328
Query: 167 ----VTLRPKSNPENLDH--LPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCG 220
V P+ L+ L DD++ MW++YLEREDS+I DLFVGQLKS L C CG
Sbjct: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
Query: 221 YCSTVFDPFWDLSLPIAKRGYP--EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIK 278
Y ST F+ F DLSLPI K+G+ +V+L DC LFTKE+ L+ + P C RCR + R K
Sbjct: 389 YRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTK 448
Query: 279 KFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAVYNLYAVS 338
K ++QRFP+ILVLHL RFS SR K + V+FPL+ L L +FAS+ VY LYA+
Sbjct: 449 KLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALC 508
Query: 339 NHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASPPSR 395
NHSG+ GHYTA CR TG WH +NDS V+P+S +QV +S+ Y+LFY+L P R
Sbjct: 509 NHSGSVHYGHYTALCRCQ-TG-WHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPR 563
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 271 bits (694), Expect = 6e-73
Identities = 144/343 (41%), Positives = 200/343 (58%), Gaps = 6/343 (1%)
Query: 53 SAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFA 110
S L GLRNLGNTC+MNSILQCL N L DY + Y D++ + + EEF
Sbjct: 772 SGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFG 831
Query: 111 KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170
+++ +WT +SP +FK I + +F GY+QQD+QE L FL+DGLH ++N+ R
Sbjct: 832 IIMKALWTGQYR-YISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
Query: 171 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 230
+ EN DHL D + W+K+ + +S I LF GQ KS++ C C S F+ F
Sbjct: 891 KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
Query: 231 DLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILV 290
LSLP+A + TL DC+RLF+KE+ L + + C CR R+ +KK I + P +L+
Sbjct: 951 YLSLPLASTS--KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLL 1008
Query: 291 LHLKRFSESRIRTSKLTTFVNFPLRDLDLREFA-SENTNHAVYNLYAVSNHSGTTMGGHY 349
+HLKRFS KL T V+FPL +LDL ++ N YNL++VSNH G GGHY
Sbjct: 1009 VHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHY 1068
Query: 350 TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 392
TAYC++ W F+D V+ +S S V++S AY+LFY P
Sbjct: 1069 TAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGP 1111
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 271 bits (694), Expect = 6e-73
Identities = 144/343 (41%), Positives = 200/343 (58%), Gaps = 6/343 (1%)
Query: 53 SAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFA 110
S L GLRNLGNTC+MNSILQCL N L DY + Y D++ + + EEF
Sbjct: 772 SGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFG 831
Query: 111 KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170
+++ +WT +SP +FK I + +F GY+QQD+QE L FL+DGLH ++N+ R
Sbjct: 832 IIMKALWTGQYR-YISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
Query: 171 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 230
+ EN DHL D + W+K+ + +S I LF GQ KS++ C C S F+ F
Sbjct: 891 KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
Query: 231 DLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILV 290
LSLP+A + TL DC+RLF+KE+ L + + C CR R+ +KK I + P +L+
Sbjct: 951 YLSLPLASTS--KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLL 1008
Query: 291 LHLKRFSESRIRTSKLTTFVNFPLRDLDLREFA-SENTNHAVYNLYAVSNHSGTTMGGHY 349
+HLKRFS KL T V+FPL +LDL ++ N YNL++VSNH G GGHY
Sbjct: 1009 VHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHY 1068
Query: 350 TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 392
TAYC++ W F+D V+ +S S V++S AY+LFY P
Sbjct: 1069 TAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGP 1111
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 271 bits (694), Expect = 6e-73
Identities = 144/343 (41%), Positives = 200/343 (58%), Gaps = 6/343 (1%)
Query: 53 SAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFA 110
S L GLRNLGNTC+MNSILQCL N L DY + Y D++ + + EEF
Sbjct: 772 SGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFG 831
Query: 111 KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170
+++ +WT +SP +FK I + +F GY+QQD+QE L FL+DGLH ++N+ R
Sbjct: 832 IIMKALWTGQYR-YISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
Query: 171 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 230
+ EN DHL D + W+K+ + +S I LF GQ KS++ C C S F+ F
Sbjct: 891 KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
Query: 231 DLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILV 290
LSLP+A + TL DC+RLF+KE+ L + + C CR R+ +KK I + P +L+
Sbjct: 951 YLSLPLASTS--KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLL 1008
Query: 291 LHLKRFSESRIRTSKLTTFVNFPLRDLDLREFA-SENTNHAVYNLYAVSNHSGTTMGGHY 349
+HLKRFS KL T V+FPL +LDL ++ N YNL++VSNH G GGHY
Sbjct: 1009 VHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHY 1068
Query: 350 TAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELASP 392
TAYC++ W F+D V+ +S S V++S AY+LFY P
Sbjct: 1069 TAYCKNAARQRWFKFDDHEVSDISVSSVKSSAAYILFYTSLGP 1111
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 199 bits (505), Expect = 5e-51
Identities = 143/382 (37%), Positives = 196/382 (51%), Gaps = 38/382 (9%)
Query: 35 LLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRD 94
LL ++ + L K S +A GLRNLGNTCFMN+ILQ LSN + Y + L +
Sbjct: 136 LLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCY-FKELPAVE 194
Query: 95 LHHGSNA-----HT--------ALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRF 141
L +G A HT +LVEEF K + +W S SP + + P F
Sbjct: 195 LRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQT-AFSPESLFYVVWKIMPNF 253
Query: 142 VGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKY-LEREDS 200
GY QQDA EF+R+LLD LH E L+ N + + + K + +
Sbjct: 254 RGYQQQDAHEFMRYLLDHLHLE-----LQGGFNGVSRSAILQENSTLSASNKCCINGAST 308
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI-----AKRGY-----PEVTLMDCM 250
+ +F G L++ + C CG S FDPF DLSL I +KR P +L DC+
Sbjct: 309 VVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCL 368
Query: 251 RLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFV 310
R FT + LD E C +C+ +++ KKF IQ+ PK+L LHLKRF + +K+ T+V
Sbjct: 369 RSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYV 428
Query: 311 NFPLRDLDLREFASENTN----HAVYNLYAVSNHSGTTMG-GHYTAYCRSPGTGEWHTFN 365
FPLR LD++ + E N +Y+L AV H G+ +G GHYTAY + G W FN
Sbjct: 429 EFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAY--ATHEGRWFHFN 486
Query: 366 DSSVTPMSSSQVRTSDAYLLFY 387
DS+VT V + AY+LFY
Sbjct: 487 DSTVTLTDEETVVKAKAYILFY 508
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 169 bits (427), Expect = 5e-42
Identities = 117/369 (31%), Positives = 168/369 (45%), Gaps = 62/369 (16%)
Query: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 115
GL GL NLGNTCFMN I+Q L++T LRD+ L + ++ S+ LV E + L Q
Sbjct: 174 GLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSC---LVCEMSSLFQE 230
Query: 116 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNP 175
++ + + P + + +A GY QQDA EFL LD LH
Sbjct: 231 FYSGHRSPHI-PYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHR------------- 276
Query: 176 ENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLP 235
H D+ G++ + I +F G L+S +TC C ST DPFWD+SL
Sbjct: 277 ----HCKGDDNGKKANNP--NHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLD 330
Query: 236 IAKRGYP---------------------EVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRK 274
+ P TL DC+R FT+ + L K C C +
Sbjct: 331 LPGSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQ 390
Query: 275 RCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASEN-------- 326
K+ ++++ P + HLKRF S K+TT+V+FPL +LD+ F + +
Sbjct: 391 ESTKQLTMKKLPIVACFHLKRFEHSAKLRRKITTYVSFPL-ELDMTPFMASSKESRMNGQ 449
Query: 327 --------TNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
N Y+L+AV NH GT GHYT++ R +W +D+ +T S V
Sbjct: 450 YQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQ-HKDQWFKCDDAIITKASIKDVL 508
Query: 379 TSDAYLLFY 387
S+ YLLFY
Sbjct: 509 DSEGYLLFY 517
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 166 bits (419), Expect = 4e-41
Identities = 90/220 (40%), Positives = 124/220 (56%), Gaps = 11/220 (5%)
Query: 27 PRSPLSPSLLLSTFVGLLLNKAKN--------SKSAQGLAGLRNLGNTCFMNSILQCLSN 78
PR P +P++ S + KN + GL GL NLGNTCFMNS +QCLSN
Sbjct: 221 PRGPSTPNVKNSNYCLPSYTAYKNYDYSEPGRNNEQPGLCGLSNLGNTCFMNSAIQCLSN 280
Query: 79 TRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQR 136
T L +Y L Y +L+ + + + +A+LI+ +W S V+P FKTQ+ R
Sbjct: 281 TPPLTEYFLNDKYQEELNFDNPLGMRGEIAKSYAELIKQMW-SGKFSYVTPRAFKTQVGR 339
Query: 137 YAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLE 196
+AP+F GY QQD QE L FLLDGLH ++NR+ +P ++ D PD + W +L+
Sbjct: 340 FAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVAEEAWENHLK 399
Query: 197 REDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 236
R DS I D+F G KS+L C +C S FDPF L+LP+
Sbjct: 400 RNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPL 439
Score = 131 bits (329), Expect = 1e-30
Identities = 65/148 (43%), Positives = 91/148 (61%), Gaps = 1/148 (0%)
Query: 242 PEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRI 301
P V L DC+ LFT ++ L ++ C C+ ++ KK + P +LV+HLKRFS SR
Sbjct: 755 PFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRFSYSRY 814
Query: 302 RTSKLTTFVNFPLRDLDLREF-ASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGE 360
KL T V+FP+ DLD+ EF + N YNL AVSNH G GGHYTA+ ++ G+
Sbjct: 815 MRDKLDTLVDFPINDLDMSEFLINPNAGPCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGK 874
Query: 361 WHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
W+ F+DSSV+ S Q+ + AY+LFY+
Sbjct: 875 WYYFDDSSVSTASEDQIVSKAAYVLFYQ 902
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 164 bits (414), Expect = 2e-40
Identities = 113/369 (30%), Positives = 171/369 (46%), Gaps = 63/369 (17%)
Query: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQT 115
GL GL NLGNTCFMN I+Q L++T LRD+ L + ++ + LV E + L +
Sbjct: 76 GLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEM---PSPELCLVCEMSSLFRE 132
Query: 116 IWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL-RPKSN 174
+++ +P+ V P + + +A GY QQDA EFL LD LH + + +N
Sbjct: 133 LYSGNPSPHV-PYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHCKGDDVGKAANN 191
Query: 175 PENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSL 234
P + + + D +F G L+S +TC C ST DP WD+SL
Sbjct: 192 PNHCNCIIDQ--------------------IFTGGLQSDVTCQACHGVSTTIDPCWDISL 231
Query: 235 PI-------------------AKRGYPEVT-LMDCMRLFTKEDVLDGDEKPTCCRCRGRK 274
+ + P +T L DC+R FT+ + L K C C+ +
Sbjct: 232 DLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQ 291
Query: 275 RCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREF------------ 322
K+ ++ + P + H KRF S + K+TT+++FPL +LD+ F
Sbjct: 292 ESTKQLTMNKLPVVACFHFKRFEHSAKQRRKITTYISFPL-ELDMTPFMASSKESRMNGQ 350
Query: 323 ----ASENTNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ N Y+L+AV NH GT GHYT++ R +W +D+ +T S V
Sbjct: 351 LQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRH-HKDQWFKCDDAVITKASIKDVL 409
Query: 379 TSDAYLLFY 387
S+ YLLFY
Sbjct: 410 DSEGYLLFY 418
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 158 bits (400), Expect = 7e-39
Identities = 84/183 (45%), Positives = 113/183 (61%), Gaps = 3/183 (1%)
Query: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLI 113
GL GL NLGNTCFMNS LQCLSNT L DY L+ Y +++ + + E +A+LI
Sbjct: 300 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 359
Query: 114 QTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKS 173
+ +W S + V+P FKTQ+ R+AP+F GY QQD+QE L FLLDGLH ++NRV +P
Sbjct: 360 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 418
Query: 174 NPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 233
++ + PD ++ W + R DS I D F G KS+L C +C S FDPF L+
Sbjct: 419 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 478
Query: 234 LPI 236
LP+
Sbjct: 479 LPL 481
Score = 123 bits (309), Expect = 3e-28
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 1/152 (0%)
Query: 238 KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS 297
K+ V L DC+ LFT + L + C C+ ++ KKF + PKILV+HLKRFS
Sbjct: 770 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 829
Query: 298 ESRIRTSKLTTFVNFPLRDLDLREFASE-NTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 356
+R KL T V FP+R L++ EF + VY+L AVSNH G GHYTAY ++
Sbjct: 830 YNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNK 889
Query: 357 GTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
G+W+ F+DS+V+ S Q+ T AY+LFY+
Sbjct: 890 LNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQ 921
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 158 bits (400), Expect = 7e-39
Identities = 84/183 (45%), Positives = 113/183 (61%), Gaps = 3/183 (1%)
Query: 56 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGS--NAHTALVEEFAKLI 113
GL GL NLGNTCFMNS LQCLSNT L DY L+ Y +++ + + E +A+LI
Sbjct: 253 GLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELI 312
Query: 114 QTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKS 173
+ +W S + V+P FKTQ+ R+AP+F GY QQD+QE L FLLDGLH ++NRV +P
Sbjct: 313 KQMW-SGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYL 371
Query: 174 NPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLS 233
++ + PD ++ W + R DS I D F G KS+L C +C S FDPF L+
Sbjct: 372 ELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLT 431
Query: 234 LPI 236
LP+
Sbjct: 432 LPL 434
Score = 123 bits (309), Expect = 3e-28
Identities = 65/152 (42%), Positives = 90/152 (59%), Gaps = 1/152 (0%)
Query: 238 KRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS 297
K+ V L DC+ LFT + L + C C+ ++ KKF + PKILV+HLKRFS
Sbjct: 723 KKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFS 782
Query: 298 ESRIRTSKLTTFVNFPLRDLDLREFASE-NTNHAVYNLYAVSNHSGTTMGGHYTAYCRSP 356
+R KL T V FP+R L++ EF + VY+L AVSNH G GHYTAY ++
Sbjct: 783 YNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNK 842
Query: 357 GTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
G+W+ F+DS+V+ S Q+ T AY+LFY+
Sbjct: 843 LNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQ 874
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 158 bits (399), Expect = 9e-39
Identities = 106/312 (33%), Positives = 156/312 (50%), Gaps = 13/312 (4%)
Query: 50 NSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHG--SNAHTALVE 107
N QG+ GL NLGNTC +N+I QCL + L +Y L Y+ L + + +
Sbjct: 36 NQPHFQGVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVAT 95
Query: 108 EFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRV 167
FA L+ +W +D VSP F + + P F QQDAQEFL +L+ LH + +
Sbjct: 96 AFAYLMTDMWLGD-SDCVSPEIFWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKY 154
Query: 168 TLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFD 227
+ + E ++ RK++ E S I LF QL S+ C C C+ +
Sbjct: 155 HYSRRRSYEK-------GSTQRCCRKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNE 207
Query: 228 PFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPK 287
F SLPI + E +L DC++ F ++D L + + C C ++ + SI + PK
Sbjct: 208 VFTVFSLPIPSKY--ECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPK 265
Query: 288 ILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREF-ASENTNHAVYNLYAVSNHSGTTMG 346
I++ HLKRF KL T +++PL +LDL + S + YNL AV NH G G
Sbjct: 266 IIIFHLKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYPKYNLCAVVNHFGDLDG 325
Query: 347 GHYTAYCRSPGT 358
GHYTA+C++ T
Sbjct: 326 GHYTAFCKNSVT 337
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 154 bits (390), Expect = 1e-37
Identities = 83/215 (38%), Positives = 118/215 (54%), Gaps = 3/215 (1%)
Query: 24 ELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELR 83
E R + PS L + + ++ K G+ GL NLGNTCFMNS LQCLSN +L
Sbjct: 275 ETRKKDGTWPSAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLT 334
Query: 84 DYCLQRLYMRDLHHGS--NAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRF 141
+Y L Y+ +L+ + + E +A L++ W+ +V P FK ++ +A +F
Sbjct: 335 EYFLNNCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIV-PHVFKNKVGHFASQF 393
Query: 142 VGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSR 201
+GY Q D+QE L FLLDGLH ++NRV + + PD E ++ W+ + R DS
Sbjct: 394 LGYQQHDSQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSV 453
Query: 202 IGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI 236
I D F G KS+L C DCG S FDPF LS+P+
Sbjct: 454 IVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPL 488
Score = 124 bits (312), Expect = 1e-28
Identities = 59/150 (39%), Positives = 90/150 (60%), Gaps = 5/150 (3%)
Query: 244 VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRT 303
V L +C+ LFT + L+ + C C+ + KK + P+IL++HLKRFS ++
Sbjct: 779 VRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSR 838
Query: 304 SKLTTFVNFPLRDLDLREFASENTNHA-----VYNLYAVSNHSGTTMGGHYTAYCRSPGT 358
KL T V FP+RDLD EF + N + Y+L AVSNH G GHYT + + +
Sbjct: 839 EKLDTLVEFPIRDLDFSEFVIQPQNESNPELYKYDLIAVSNHYGGMRDGHYTTFACNKDS 898
Query: 359 GEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
G+WH F+D+SV+P++ +Q+ + AY+LFY+
Sbjct: 899 GQWHYFDDNSVSPVNENQIESKAAYVLFYQ 928
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 154 bits (388), Expect = 2e-37
Identities = 113/381 (29%), Positives = 171/381 (44%), Gaps = 69/381 (18%)
Query: 47 KAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHG--SNAHTA 104
+ K S GL GL NLGNTCFMN I+Q L++ L+D+ ++ D H ++
Sbjct: 352 RRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDF-----FLSDKHKCIMTSPSLC 406
Query: 105 LVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEV 164
LV E + L +++ S + P + I +A GY QQDA EFL +LD LH
Sbjct: 407 LVCEMSSLFHAMYSGSRTPHI-PYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHR-- 463
Query: 165 NRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCST 224
H DD G++ + I +F G L+S +TC C ST
Sbjct: 464 ---------------HSKDDSGGQEANNPNCC--NCIIDQIFTGGLQSDVTCQACHSVST 506
Query: 225 VFDPFWDLSLPIAKR-----------------------GYPEVTLMDCMRLFTKEDVLDG 261
DP WD+SL + G P +T DC++ FT+ + L
Sbjct: 507 TIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLT--DCLQWFTRPEHLGS 564
Query: 262 DEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLRE 321
K C C+ + K+ ++++ P + HLKRF + K+ TF++FPL +LD+
Sbjct: 565 SAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPL-ELDMTP 623
Query: 322 FASEN---------------TNHAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFND 366
F + N Y+L+AV NH GT GHYT++ R +W + +D
Sbjct: 624 FLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQ-KDQWFSCDD 682
Query: 367 SSVTPMSSSQVRTSDAYLLFY 387
+ +T + + S+ YLLFY
Sbjct: 683 AIITKATIEDLLYSEGYLLFY 703
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 153 bits (387), Expect = 2e-37
Identities = 87/232 (37%), Positives = 125/232 (53%), Gaps = 9/232 (3%)
Query: 10 PEDPPAAPFPALAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFM 69
PE A+P P P SP+S + + + G GL NLGNTCFM
Sbjct: 455 PETHLASPKPTCMVPPMPHSPVSGDSVEEE------EEEEKKVCLPGFTGLVNLGNTCFM 508
Query: 70 NSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTA--LVEEFAKLIQTIWTSSPNDVVSP 127
NS++Q LSNTRELRD+ R + ++++ + T L FA L++ +W + + P
Sbjct: 509 NSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGT-HHAFQP 567
Query: 128 SEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKG 187
S+ K + A +F GY Q DAQEF+ FLLDGLH ++NR+ +P + + D PD+
Sbjct: 568 SKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRPDEVVA 627
Query: 188 RQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKR 239
+ W+++ R DS I DLF GQ KS L C C S FDPF L +P+ ++
Sbjct: 628 EEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVPLPQK 679
Score = 109 bits (272), Expect = 5e-24
Identities = 63/159 (39%), Positives = 87/159 (54%), Gaps = 10/159 (6%)
Query: 245 TLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFS-ESRIRT 303
TL C+ LFT+ +VL +E C +C+ + K+ + R P +L++ LKRFS S I
Sbjct: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWR 1118
Query: 304 SKLTTFVNFPLRDLDLREFASENTNHAV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGE- 360
K+ V FP+R+LDL +F + Y+LYAV NH G +GGHYTA R P
Sbjct: 1119 DKINDLVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSS 1178
Query: 361 ------WHTFNDSSVTPMSSSQVRTSDAYLLFYELASPP 393
W F+DS+VT + SQV T AY+LFY + P
Sbjct: 1179 QRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRRRNSP 1217
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 152 bits (384), Expect = 5e-37
Identities = 81/196 (41%), Positives = 116/196 (59%), Gaps = 7/196 (3%)
Query: 55 QGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH----GSNAHTALVEEFA 110
+G GL NLGNTCFMNS +QC+SNT+ L Y + ++ +L+ G H A +
Sbjct: 529 KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKC--YG 586
Query: 111 KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170
L+Q +W+ + V +P + + I +YAP+F G+ QQD+QE L FLLDGLH ++NRV +
Sbjct: 587 DLVQELWSGTQKSV-APLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEK 645
Query: 171 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 230
P ++ D PD E + W +L R S I DLF GQL+S + C CG+ S FDPF
Sbjct: 646 PYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFN 705
Query: 231 DLSLPIAKRGYPEVTL 246
LSLP+ Y ++ +
Sbjct: 706 FLSLPLPMDSYMDLEI 721
Score = 64.7 bits (156), Expect = 1e-10
Identities = 27/58 (46%), Positives = 38/58 (65%), Gaps = 1/58 (1%)
Query: 331 VYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
+YNLYA+S HSG GGHY Y ++P +W+ +NDSS + ++ T AY+LFYE
Sbjct: 1311 IYNLYAISCHSGILSGGHYITYAKNPNC-KWYCYNDSSCEELHPDEIDTDSAYILFYE 1367
Score = 47.8 bits (112), Expect = 2e-05
Identities = 23/70 (32%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Query: 244 VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRF---SESR 300
+ L C+R FT E+ L E C +C+ KK + R P L++HLKRF ++
Sbjct: 1031 INLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQW 1090
Query: 301 IRTSKLTTFV 310
I++ K+ F+
Sbjct: 1091 IKSQKIVRFL 1100
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 152 bits (384), Expect = 5e-37
Identities = 81/191 (42%), Positives = 114/191 (59%), Gaps = 7/191 (3%)
Query: 55 QGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH----GSNAHTALVEEFA 110
+G GL NLGNTCFMNS +QC+SNT+ L Y + ++ +L+ G H A +
Sbjct: 731 KGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKC--YG 788
Query: 111 KLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLR 170
L+Q +W+ + +V +P + + I +YAPRF G+ QQD+QE L FLLDGLH ++NRV +
Sbjct: 789 DLVQELWSGTQKNV-APLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEK 847
Query: 171 PKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFW 230
P ++ D PD E + W +L R S + DLF GQL+S + C CG+ S FDPF
Sbjct: 848 PYVELKDSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFN 907
Query: 231 DLSLPIAKRGY 241
LSLP+ Y
Sbjct: 908 FLSLPLPMDSY 918
Score = 64.3 bits (155), Expect = 2e-10
Identities = 27/58 (46%), Positives = 38/58 (65%), Gaps = 1/58 (1%)
Query: 331 VYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYE 388
+YNLYA+S HSG GGHY Y ++P +W+ +NDSS + ++ T AY+LFYE
Sbjct: 1509 IYNLYAISCHSGILGGGHYVTYAKNPNC-KWYCYNDSSCKELHPDEIDTDSAYILFYE 1565
Score = 53.1 bits (126), Expect = 4e-07
Identities = 28/79 (35%), Positives = 37/79 (46%)
Query: 244 VTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRT 303
+ L C+R FT E+ L +E C +C+ KK + R P IL++HLKRF R
Sbjct: 1233 INLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNGRW 1292
Query: 304 SKLTTFVNFPLRDLDLREF 322
K V FP D F
Sbjct: 1293 IKSQKIVKFPRESFDPSAF 1311
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 136 bits (343), Expect = 3e-32
Identities = 82/244 (33%), Positives = 123/244 (50%), Gaps = 44/244 (18%)
Query: 192 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 236
+K ++ S I D+F G + SS+ C C S + F DLSLPI
Sbjct: 465 KKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHP 524
Query: 237 -------------AKRGY--------------PEVTLMDCMRLFTKEDVLDGDEKPTCCR 269
A +G+ P VTL DC+ F D L GD +C +
Sbjct: 525 TSIVKAGSCGEAYAPQGWIAFFMEYVKSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEK 584
Query: 270 CRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNH 329
C+ + +K +Q FP+IL +HLKRF + ++K++T V+FPL LDL+ F ++++
Sbjct: 585 CKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPA 644
Query: 330 AV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFY 387
+ Y+L +V H GT GHY AYCR+ W+ F+D SVT +S S V+ ++AY+LFY
Sbjct: 645 QIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFY 704
Query: 388 ELAS 391
+S
Sbjct: 705 RKSS 708
Score = 84.7 bits (208), Expect = 1e-16
Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%)
Query: 54 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT----ALVEEF 109
A+GL GL+N+GNTC+MN+ LQ LSN L + L G A T A+ + +
Sbjct: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC--------GGLARTDKKPAICKSY 232
Query: 110 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 169
KL+ +W S V P+ I+ P F GY+QQDAQEFLR L+D LH E+ +
Sbjct: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVM 292
Query: 170 RPKSNPENL 178
+ +P+ +
Sbjct: 293 EVEEDPQTI 301
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 133 bits (335), Expect = 2e-31
Identities = 82/252 (32%), Positives = 123/252 (48%), Gaps = 52/252 (20%)
Query: 192 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 236
+K ++ S I D+F G + SS+ C C S + F DLSLPI
Sbjct: 465 KKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHP 524
Query: 237 -------------AKRGY----------------------PEVTLMDCMRLFTKEDVLDG 261
A +G+ P VTL DC+ F D L G
Sbjct: 525 TSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKG 584
Query: 262 DEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLRE 321
D +C +C+ + +K +Q FP+IL +HLKRF + ++K++T V+FPL LDL+
Sbjct: 585 DNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQP 644
Query: 322 FASENTNHAV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRT 379
F ++++ + Y+L +V H GT GHY AYCR+ W+ F+D SVT +S S V+
Sbjct: 645 FLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQN 704
Query: 380 SDAYLLFYELAS 391
++AY+LFY +S
Sbjct: 705 AEAYVLFYRKSS 716
Score = 84.7 bits (208), Expect = 1e-16
Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%)
Query: 54 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT----ALVEEF 109
A+GL GL+N+GNTC+MN+ LQ LSN L + L G A T A+ + +
Sbjct: 181 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC--------GGLARTDKKPAICKSY 232
Query: 110 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 169
KL+ +W S V P+ I+ P F GY+QQDAQEFLR L+D LH E+ +
Sbjct: 233 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVM 292
Query: 170 RPKSNPENL 178
+ +P+ +
Sbjct: 293 EVEEDPQTI 301
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 133 bits (335), Expect = 2e-31
Identities = 82/252 (32%), Positives = 123/252 (48%), Gaps = 52/252 (20%)
Query: 192 RKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPI--------------- 236
+K ++ S I D+F G + SS+ C C S + F DLSLPI
Sbjct: 434 KKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHP 493
Query: 237 -------------AKRGY----------------------PEVTLMDCMRLFTKEDVLDG 261
A +G+ P VTL DC+ F D L G
Sbjct: 494 TSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKG 553
Query: 262 DEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLRE 321
D +C +C+ + +K +Q FP+IL +HLKRF + ++K++T V+FPL LDL+
Sbjct: 554 DNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFSTKISTHVSFPLEGLDLQP 613
Query: 322 FASENTNHAV--YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRT 379
F ++++ + Y+L +V H GT GHY AYCR+ W+ F+D SVT +S S V+
Sbjct: 614 FLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTVQN 673
Query: 380 SDAYLLFYELAS 391
++AY+LFY +S
Sbjct: 674 AEAYVLFYRKSS 685
Score = 84.7 bits (208), Expect = 1e-16
Identities = 49/129 (37%), Positives = 70/129 (54%), Gaps = 12/129 (9%)
Query: 54 AQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHT----ALVEEF 109
A+GL GL+N+GNTC+MN+ LQ LSN L + L G A T A+ + +
Sbjct: 150 ARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDC--------GGLARTDKKPAICKSY 201
Query: 110 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 169
KL+ +W S V P+ I+ P F GY+QQDAQEFLR L+D LH E+ +
Sbjct: 202 LKLMTELWHKSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVM 261
Query: 170 RPKSNPENL 178
+ +P+ +
Sbjct: 262 EVEEDPQTI 270
>gi|169217654 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 131 bits (330), Expect = 9e-31
Identities = 105/369 (28%), Positives = 170/369 (46%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + LP ++ + ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC----------------LPGHKQA-----DHHSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLVKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFAS-ENTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S +NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQQNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
>gi|239758075 PREDICTED: similar to deubiquitinating enzyme DUB1
[Homo sapiens]
Length = 530
Score = 131 bits (329), Expect = 1e-30
Identities = 105/369 (28%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + + +DH ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC-------LPGHKQVDH--------------HSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLVKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFAS-ENTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S +NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQQNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
>gi|113415490 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 131 bits (329), Expect = 1e-30
Identities = 105/369 (28%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + + +DH ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC-------LPGHKQVDH--------------HSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLVKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFASE-NTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S+ NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
>gi|113415488 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 131 bits (329), Expect = 1e-30
Identities = 105/369 (28%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + + +DH ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC-------LPGHKQVDH--------------HSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLVKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFASE-NTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S+ NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
>gi|113415486 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 131 bits (329), Expect = 1e-30
Identities = 105/369 (28%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + + +DH ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC-------LPGHKQVDH--------------HSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLVKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFASE-NTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S+ NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
>gi|113415484 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 131 bits (329), Expect = 1e-30
Identities = 105/369 (28%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + + +DH ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC-------LPGHKQVDH--------------HSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLVKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFASE-NTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S+ NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
>gi|113415482 PREDICTED: Ubiquitin carboxyl-terminal hydrolase
17-like protein 5 [Homo sapiens]
Length = 530
Score = 131 bits (329), Expect = 1e-30
Identities = 105/369 (28%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + + +DH ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC-------LPGHKQVDH--------------HSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLAKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFASE-NTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S+ NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
>gi|113415480 PREDICTED: similar to deubiquitinating enzyme 1 [Homo
sapiens]
Length = 530
Score = 131 bits (329), Expect = 1e-30
Identities = 105/369 (28%), Positives = 169/369 (45%), Gaps = 56/369 (15%)
Query: 21 LAKELRPRSPLSPSLLLSTFVGLLLNKAKNSKSAQGLAGLRNLGNTCFMNSILQCLSNTR 80
+A++L PR L S VG AGL+N+GNTC++N+ LQCL+ T
Sbjct: 58 VARQLAPREKLPLSSRRPAAVG---------------AGLQNMGNTCYVNASLQCLTYTP 102
Query: 81 ELRDYCLQRLYMRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPR 140
L +Y L R + + H ++ A + + + +P V+ PS Q A
Sbjct: 103 PLANYMLSREHSQTCHRHKGCMLCTMQ--AHITRAL--HNPGHVIQPS------QALAAG 152
Query: 141 FVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDS 200
F Q+DA EFL F +D + + +DH ++ +
Sbjct: 153 FHRGKQEDAHEFLMFTVDAMKKAC-------LPGHKQVDH--------------HSKDTT 191
Query: 201 RIGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLD 260
I +F G +S + C C S FDP+ D++L I ++ + K + L+
Sbjct: 192 LIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDI----QAAQSVQQALEQLVKPEELN 247
Query: 261 GDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLR 320
G+ C C R K ++ K+L+L LKRFS+ + +K+ V +P LD++
Sbjct: 248 GENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSD--VTGNKIAKNVQYP-ECLDMQ 304
Query: 321 EFASE-NTNHAVYNLYAVSNHSG-TTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVR 378
+ S+ NT VY LYAV H+G + GHY +Y ++ G+W+ +D+ VT S + V
Sbjct: 305 PYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQ-EGQWYKMDDAEVTASSITSVL 363
Query: 379 TSDAYLLFY 387
+ AY+LFY
Sbjct: 364 SQQAYVLFY 372
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,863,257
Number of Sequences: 37866
Number of extensions: 708272
Number of successful extensions: 2535
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 107
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2071
Number of HSP's gapped (non-prelim): 185
length of query: 396
length of database: 18,247,518
effective HSP length: 104
effective length of query: 292
effective length of database: 14,309,454
effective search space: 4178360568
effective search space used: 4178360568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.