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Search of human proteins with 28372497
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28372497 ubiquitin protein ligase E3 component n-recognin 1
[Homo sapiens]
(1749 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28372497 ubiquitin protein ligase E3 component n-recognin 1 [... 3557 0.0
gi|27597061 ubiquitin protein ligase E3 component n-recognin 2 [... 1651 0.0
gi|160948610 E3 ubiquitin-protein ligase UBR3 [Homo sapiens] 129 2e-29
gi|4826776 Janus kinase 2 [Homo sapiens] 38 0.099
gi|171460956 ubiquitin specific peptidase like 1 [Homo sapiens] 37 0.17
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 36 0.29
gi|154091003 zinc finger protein 470 [Homo sapiens] 35 0.64
gi|109891938 disks large-associated protein 4 isoform c [Homo sa... 34 1.4
gi|34335251 disks large-associated protein 4 isoform b [Homo sap... 34 1.4
gi|34335253 disks large-associated protein 4 isoform a [Homo sap... 34 1.4
gi|24233517 IKK interacting protein isoform 1 [Homo sapiens] 34 1.4
gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3 c... 33 1.9
gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3 c... 33 1.9
gi|122937213 zinc finger protein 99 [Homo sapiens] 33 2.4
gi|145580590 hepatitis C virus F protein-binding protein 2 [Homo... 33 3.2
gi|34303932 transmembrane and coiled-coil domains 5A [Homo sapiens] 33 3.2
gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens] 32 4.2
gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens] 32 4.2
gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens] 32 4.2
gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens] 32 4.2
gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [... 32 4.2
gi|86262149 zinc finger and BTB domain containing 7C [Homo sapiens] 32 4.2
gi|90903231 huntingtin [Homo sapiens] 32 5.4
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 32 5.4
gi|187761324 shootin1 isoform a [Homo sapiens] 32 5.4
gi|50511340 shootin1 isoform b [Homo sapiens] 32 5.4
gi|83320068 zinc finger protein 253 [Homo sapiens] 32 5.4
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 32 7.1
gi|229577396 zinc finger protein 583 [Homo sapiens] 32 7.1
gi|229577249 zinc finger protein 583 [Homo sapiens] 32 7.1
>gi|28372497 ubiquitin protein ligase E3 component n-recognin 1 [Homo
sapiens]
Length = 1749
Score = 3557 bits (9224), Expect = 0.0
Identities = 1749/1749 (100%), Positives = 1749/1749 (100%)
Query: 1 MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLE 60
MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLE
Sbjct: 1 MADEEAGGTERMEISAELPQTPQRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLE 60
Query: 61 KQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPT 120
KQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPT
Sbjct: 61 KQEESVQMSIFTPLEWYLFGEDPDICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPT 120
Query: 121 CVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRC 180
CVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRC
Sbjct: 121 CVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRC 180
Query: 181 PLNEEVIVQARKIFPSVIKYVVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDH 240
PLNEEVIVQARKIFPSVIKYVVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDH
Sbjct: 181 PLNEEVIVQARKIFPSVIKYVVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDH 240
Query: 241 VIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHV 300
VIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHV
Sbjct: 241 VIYSLQRALDCELAEAQLHTTAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHV 300
Query: 301 EVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDA 360
EVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDA
Sbjct: 301 EVLHSEIMAHQKFALRLGSWMNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDA 360
Query: 361 KLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQ 420
KLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQ
Sbjct: 361 KLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQ 420
Query: 421 MFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLK 480
MFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLK
Sbjct: 421 MFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQDKLGRVYAVICDLK 480
Query: 481 YILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQM 540
YILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQM
Sbjct: 481 YILISKPTIWTERLRMQFLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQM 540
Query: 541 QLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRV 600
QLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRV
Sbjct: 541 QLKNILLMFQEWCACDEELLLVAYKECHKAVMRCSTSFISSSKTVVQSCGHSLETKSYRV 600
Query: 601 SEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVV 660
SEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVV
Sbjct: 601 SEDLVSIHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVV 660
Query: 661 AEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEA 720
AEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEA
Sbjct: 661 AEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEA 720
Query: 721 FNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEP 780
FNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEP
Sbjct: 721 FNKTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEP 780
Query: 781 MPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSK 840
MPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSK
Sbjct: 781 MPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSK 840
Query: 841 TQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAID 900
TQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAID
Sbjct: 841 TQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAID 900
Query: 901 TDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLE 960
TDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLE
Sbjct: 901 TDSNLWTEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLE 960
Query: 961 KLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERK 1020
KLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERK
Sbjct: 961 KLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIKNDEITHDKEKAERK 1020
Query: 1021 RKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRI 1080
RKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRI
Sbjct: 1021 RKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRI 1080
Query: 1081 ALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEA 1140
ALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEA
Sbjct: 1081 ALGPKRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEA 1140
Query: 1141 LDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLC 1200
LDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLC
Sbjct: 1141 LDPLFMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLC 1200
Query: 1201 KSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIF 1260
KSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIF
Sbjct: 1201 KSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPIF 1260
Query: 1261 FNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPML 1320
FNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPML
Sbjct: 1261 FNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPML 1320
Query: 1321 TWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVR 1380
TWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVR
Sbjct: 1321 TWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLVR 1380
Query: 1381 LLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFH 1440
LLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFH
Sbjct: 1381 LLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLFH 1440
Query: 1441 LITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVS 1500
LITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVS
Sbjct: 1441 LITMAHMLQILLTVDTGLPLAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIPGWYLWVS 1500
Query: 1501 LKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDT 1560
LKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDT
Sbjct: 1501 LKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEYWDT 1560
Query: 1561 VRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDE 1620
VRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDE
Sbjct: 1561 VRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSADDE 1620
Query: 1621 RKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEG 1680
RKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEG
Sbjct: 1621 RKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVLVEG 1680
Query: 1681 KARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQM 1740
KARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQM
Sbjct: 1681 KARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQETNQM 1740
Query: 1741 LFGFNWQLL 1749
LFGFNWQLL
Sbjct: 1741 LFGFNWQLL 1749
>gi|27597061 ubiquitin protein ligase E3 component n-recognin 2 [Homo
sapiens]
Length = 1755
Score = 1651 bits (4276), Expect = 0.0
Identities = 833/1752 (47%), Positives = 1168/1752 (66%), Gaps = 43/1752 (2%)
Query: 23 QRLASWWDQQVDFYTAFLHHLAQLVPEIYFAEMDPDLEKQEESVQMSIFTPLEWYLFGED 82
+ +A W Q D HLA VP+IY +P +K++ Q + P+EWYL GED
Sbjct: 22 EEIAGKWLQATDLTREVYQHLAHYVPKIYCRGPNPFPQKEDMLAQHVLLGPMEWYLCGED 81
Query: 83 PDICLEKLKHSGA-FQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMH 141
P KL+ + LCGRVFK GE TYSCRDCA+DPTCVLCM+CF S+H++HRY+M
Sbjct: 82 PAFGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMT 141
Query: 142 TSTGGGFCDCGDTEAWKTGPFCVNHEPGRAGTIKENSRCP-LNEEVIVQARKIFPSVIKY 200
TS GGGFCDCGDTEAWK GP+C HE + +E L+E+VI + IF +Y
Sbjct: 142 TSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPLVHLSEDVIARTYNIFAITFRY 201
Query: 201 VVEMTIWEEEKELPPELQIREKNERYYCVLFNDEHHSYDHVIYSLQRALDCELAEAQLHT 260
VE+ WE+E ELP +L++ EK++ YYC+LFNDE H+Y+ VIY+LQ+A++C EA
Sbjct: 202 AVEILTWEKESELPADLEMVEKSDTYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFA 261
Query: 261 TAIDKEGRRAVKAGAYAACQEAKEDIKSHSENVSQHPLHVEVLHSEIMAHQKFALRLGSW 320
T +D++GRR+V+ G + C++AK I ++ ++ PL V+V+HS I+AHQ F L+L SW
Sbjct: 262 TTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTK-PLKVQVMHSSIVAHQNFGLKLLSW 320
Query: 321 MNKIMSYSSDFRQIFCQACLREEPDSENPCLISRLMLWDAKLYKGARKILHELIFSSFFM 380
+ I+ YS R+I CQ L+E PD EN L+ RLML D+KL+KGAR + H+L SS M
Sbjct: 321 LGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLSDSKLWKGARSVYHQLFMSSLLM 380
Query: 381 EMEYKKLFAMEFVKYYKQLQKEYISDDHDRSISITALSVQMFTVPTLARHLIEEQNVISV 440
+++YKKLFA+ F K Y+QLQ++++ DDH+R++S+TALSVQ FT PTLAR LI E+N++S+
Sbjct: 381 DLKYKKLFAVRFAKNYQQLQRDFMEDDHERAVSVTALSVQFFTAPTLARMLITEENLMSI 440
Query: 441 ITETLLEVLPEYLDRNNKFNFQGYSQ---DKLGRVYAVICDLKYILISKPTIWTERLRMQ 497
I +T ++ L + D +F F+ Y+ K RV ++I DLKY+LISKPT W++ LR +
Sbjct: 441 IIKTFMDHL-RHRDAQGRFQFERYTALQAFKFRRVQSLILDLKYVLISKPTEWSDELRQK 499
Query: 498 FLEGFRSFLKILTCMQGMEEIRRQVGQHIEVDPDWEAAIAIQMQLKNILLMFQEWCACDE 557
FLEGF +FL++L CMQGM+ I RQVGQHIE++P+WEAA +QM+L +++ M Q+WCA DE
Sbjct: 500 FLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTLQMKLTHVISMMQDWCASDE 559
Query: 558 ELLLVAYKECHKAVMRCSTSFISSSKTVVQS-CGHSLETKSYRVSEDLVSIHLPLSRTLA 616
++L+ AYK+C +M+C + + + S CGHS+ET Y VS++ VSIHLP+SR LA
Sbjct: 560 KVLIEAYKKCLAVLMQCHGGYTDGEQPITLSICGHSVETIRYCVSQEKVSIHLPVSRLLA 619
Query: 617 GLHVRLSRLGAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVF 676
GLHV LS+ + E + + +L+E+PLRCLVL AQV A MWRRNG SL++Q++
Sbjct: 620 GLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIY 679
Query: 677 YYQDVKCREEMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFN-----KTISTK--D 729
YY +VKCR EM+DKD++MLQ G S+MDPN FL+++L R+EL + F+ K S++
Sbjct: 680 YYHNVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFELYQIFSTPDYGKRFSSEITH 739
Query: 730 QDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKN 789
+D+++Q NTLIEEML ++I +VGER+ PGVG V + REIIH L I+PM HS + K+
Sbjct: 740 KDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKREIIHQLSIKPMAHSELVKS 799
Query: 790 LPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHM 849
LPE+EN ETG+E+VI VA FKKPG++G G+YELK E K+FN+YFYH+S+ + SKAE
Sbjct: 800 LPEDENKETGMESVIEAVAHFKKPGLTGRGMYELKPECAKEFNLYFYHFSRAEQSKAEEA 859
Query: 850 QKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNCDIMMYILRTVFERAIDTDSNLWTEG 909
Q+K ++Q +D ALPPP P FCP F+ ++N+L D+M+ I+ T+ + A++ + W+E
Sbjct: 860 QRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCIMGTILQWAVEHNGYAWSES 919
Query: 910 MLQMAFHILALGLLEEKQQLQKAPEEEV-TFDFYHKASRLGSSAMN---IQMLLEKLKGI 965
MLQ H++ + L EEKQ L+ EE V TF F K S+ G + N I +LE L+
Sbjct: 920 MLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPGEAPKNSPSILAMLETLQNA 979
Query: 966 PQLEGQKDMITWILQMFDTVKRLREKSCLI-VATTSGSESIKNDEITHDKEKAERKRKAE 1024
P LE KDMI WIL+ F+ VK++RE S VA T G+ +E + DK+KAERKRKAE
Sbjct: 980 PYLEVHKDMIRWILKTFNAVKKMRESSPTSPVAETEGTIM---EESSRDKDKAERKRKAE 1036
Query: 1025 AARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALGP 1084
ARL R+KIMAQMS +Q++FI+ +K ++ T E+ ++++ +P SD + ALGP
Sbjct: 1037 IARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDH--SPVASDMTLTALGP 1094
Query: 1085 KRGPSVTEKEVLTCILCQEEQEVKIENNAMVLSACVQKSTALTQHRGKPIELSGEALDPL 1144
+ +++ +TCILCQEEQEVK+E+ AMVL+A VQ+ST L+++R K I+ E DPL
Sbjct: 1095 AQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKNRSKFIQ-DPEKYDPL 1153
Query: 1145 FMDPDLAYGTYTGSCGHVMHAVCWQKYFEAVQLSSQQR-----IHVDLFDLESGEYLCPL 1199
FM PDL+ GT+T SCGH+MHA CWQ+YF++VQ Q+R +H +D+E+GE+LCPL
Sbjct: 1154 FMHPDLSCGTHTSSCGHIMHAHCWQRYFDSVQAKEQRRQQRLRLHTS-YDVENGEFLCPL 1212
Query: 1200 CKSLCNTVIPIIPLQPQKINSENADALAQLLTLARWIQTVLARISGYNIRHAKGENPIPI 1259
C+ L NTVIP++ L P+ I + + Q L +WI+T+ +I + P
Sbjct: 1213 CECLSNTVIPLL-LPPRNIFNNRLNFSDQP-NLTQWIRTISQQIKALQFLRKEESTPNNA 1270
Query: 1260 FFNQGMGDSTLEFHSILSFGVESSIKYSNSIKEMVILFATTIYRIGLKVPPDERDPRVPM 1319
L+ I YS SIKEM+ F T Y++GLKV P+E DPRVP+
Sbjct: 1271 STKNSENVDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKVGLKVHPNEEDPRVPI 1330
Query: 1320 LTWSTCAFTIQAIENLLGDEGKPLFGALQNRQHNGLKALMQFAVAQRITCPQVLIQKHLV 1379
+ W +CA+TIQ+IE +L DE KPLFG L R + L++L +FA A ++Q H
Sbjct: 1331 MCWGSCAYTIQSIERILSDEDKPLFGPLPCRLDDCLRSLTRFAAAHWTVASVSVVQGHFC 1390
Query: 1380 RLLSVVLPNIKSEDTPCLLSIDLFHVLVGAVLAFPSLYWDDPVDLQPSSVSSSYNHLYLF 1439
+L + ++PN E+ PC+L ID+FH+LVG VLAFP+L D S +S L++F
Sbjct: 1391 KLFASLVPNDSHEELPCILDIDMFHLLVGLVLAFPALQCQDF-----SGISLGTGDLHIF 1445
Query: 1440 HLITMAHMLQILLTVDTGLP-LAQVQEDSEEAHSASSFFAEISQYTSGSIGCDIP-GWYL 1497
HL+TMAH++QILLT T + Q EE + + + + QYT GS +IP GW+L
Sbjct: 1446 HLVTMAHIIQILLTSCTEENGMDQENPPCEEESAVLALYKTLHQYT-GSALKEIPSGWHL 1504
Query: 1498 WVSLKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSLPTNLFLLFQEY 1557
W S++ GI P+L+C+ALFFHYL GV P ++ + LCSYLSLP NL LFQE
Sbjct: 1505 WRSVRAGIMPFLKCSALFFHYLNGVPSPPDIQVPGTS-HFEHLCSYLSLPNNLICLFQEN 1563
Query: 1558 WDTVRPLLQRWCADPALLNCLKQKNTVVRYPRKRNSLIELPDDYSCLLNQASHFRCPRSA 1617
+ + L++ WC + + L+ + +RYPR+ N LI LP+DYS L+NQAS+F CP+S
Sbjct: 1564 SEIMNSLIESWCRNSEVKRYLEGERDAIRYPRESNKLINLPEDYSSLINQASNFSCPKSG 1623
Query: 1618 DDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHCGAGVCIFLKIRECRVVL 1677
D+ + P LCL CG++LCSQ+ CCQ + GE+VGAC H CG+GV IFL++REC+V+
Sbjct: 1624 GDKSRAPTLCLVCGSLLCSQSYCCQTELEGEDVGACTAHTYSCGSGVGIFLRVRECQVLF 1683
Query: 1678 VEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHLVWQQHCIIEEIARSQET 1737
+ GK +GC Y PYLD+YGETD GL+RGNPLHL +ER++K+ +W QH + EEI +QE
Sbjct: 1684 LAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLWHQHSVTEEIGHAQEA 1743
Query: 1738 NQMLFGFNWQLL 1749
NQ L G +WQ L
Sbjct: 1744 NQTLVGIDWQHL 1755
>gi|160948610 E3 ubiquitin-protein ligase UBR3 [Homo sapiens]
Length = 1888
Score = 129 bits (324), Expect = 2e-29
Identities = 143/632 (22%), Positives = 288/632 (45%), Gaps = 91/632 (14%)
Query: 352 ISRLMLWDAKLYKGARKILHELIFSSFFMEMEYKKLFAMEFVKYY----KQLQKEYISDD 407
+ L+ W K Y+ +K++ L+ + + EYK F FV++Y K L+K + SD
Sbjct: 382 LEELLFWTIK-YEFPQKMVTFLL--NMLPDQEYKVAFTKTFVQHYAFIMKTLKKSHESDT 438
Query: 408 HDRSISITALSVQMFTVPTLARHLIEEQNVISVITETLLEVLPEYLDRNNKFNFQGYSQD 467
S I +SVQ+F+ LAR + EE ++ ++ LL ++ L ++ QD
Sbjct: 439 --MSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMESCLIKSEL-------QD 489
Query: 468 KLGRVYAVICDLKYILISKPTIWT-----------ERLRMQFLEGFR---SFLKILTCMQ 513
+ ++ V+ + L+ T W + + +FLE +++ ++ Q
Sbjct: 490 EENSLHVVV-NCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTWMNFVSFFQ 548
Query: 514 GMEEIRRQVGQHIEVDPD-WEAAIAIQMQLKNILLMFQEWCACDEELL-LVAYKECHKAV 571
GM +R++ +H+E + + AA A +++ AC + + L+++ + +
Sbjct: 549 GMNLNKRELNEHVEFESQTYYAAFAAELE------------ACAQPMWGLLSHCKVRETQ 596
Query: 572 MRCSTSFISSSKTVVQSCGHSLETKSYRVS------EDLVSIHLPLSRTLAGLHVRLSRL 625
++ VV+ C +L+ ++ + V+ HLPL R A + +
Sbjct: 597 --------EYTRNVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKC 648
Query: 626 GAVSRLHEFVSFEDFQVEVLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCRE 685
+ L + ++ +++++ +PL+ +A++ + MW RNGL + Q Y
Sbjct: 649 QELD-LDSVLPDQEMLMKLMI-HPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCN 706
Query: 686 EMYDKDIIMLQIGASLMDPNKFLLLVLQRYELAEAFNKTISTKDQDLI---KQYNTLIEE 742
M D DI +LQ+ AS +DP+ F+ V +R+++ + T++++ Q+ + + +++E
Sbjct: 707 SMIDPDIYLLQVCASRLDPDYFISSVFERFKVVDLL--TMASQHQNTVLDAEHERSMLEG 764
Query: 743 MLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNETGL-- 800
L L+ ++ R G+ + +E+ E++ LC+ HS++ +PEN N ++G+
Sbjct: 765 ALTFLVILLSLRLHLGMSD---DEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIP 821
Query: 801 -----ENVINKVATFKKP-----GVSGHGVY----ELKDESLKDFNMYFYHYSKTQHSKA 846
E+V++ VA FK P G G+Y E+ D+ + + A
Sbjct: 822 GSYSFESVLSAVADFKAPVFEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSA 881
Query: 847 EHMQKKRRKQENKDEALPPPP---PPEFCPAFSKVINLLNCDIMMYILRTVFERAIDTDS 903
KQ K P PP P++ ++ LL+C + +L T+ + +
Sbjct: 882 MDRYTAFLKQSGKFPGNPWPPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQ 941
Query: 904 NLWTEGMLQMAFHILALGLLEEKQQLQKAPEE 935
NL +E +L M +++ LGL E +++ EE
Sbjct: 942 NL-SEHVLCMVLYLIELGL--ENSAEEESDEE 970
Score = 107 bits (267), Expect = 1e-22
Identities = 73/245 (29%), Positives = 118/245 (48%), Gaps = 38/245 (15%)
Query: 1501 LKNGITPYLRCAALFFHYLLGVTPPEELHTNSAEGEYSALCSYLSL-PTNLFLLFQEYWD 1559
L++ P+LR +L H+L G E+L + E E+S L S L L PT ++
Sbjct: 1646 LQDFCLPFLRITSLLQHHLFG----EDLPSCQEEEEFSVLASCLGLLPT--------FYQ 1693
Query: 1560 TVRPLLQRWCAD---PAL----LNCLKQKNTVVRYPRKRNSLI------------ELPDD 1600
T P + C D PA C + K+ R+ + +L+ +LP++
Sbjct: 1694 TEHPFISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQESKWKLPHLLQLPEN 1753
Query: 1601 YSCLLNQASHFRCPRSADDERKHPVLCLFCGAILCSQNICCQEIVNGEEVGACIFHALHC 1660
Y+ + Q H + K P +CL CG +C + +CC++ + C+ H+ +C
Sbjct: 1754 YNTIF-QYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQ----QSYCECVLHSQNC 1808
Query: 1661 GAGVCIFLKIRECRVVLVEGKARGCAYPAPYLDEYGETDPGLKRGNPLHLSRERYRKLHL 1720
GAG IFL I ++++ G R C + + YLD +GE D L+RG PL++ +ERY+ L
Sbjct: 1809 GAGTGIFLLINASVIIIIRGH-RFCLWGSVYLDAHGEEDRDLRRGKPLYICKERYKVLEQ 1867
Query: 1721 VWQQH 1725
W H
Sbjct: 1868 QWISH 1872
Score = 73.2 bits (178), Expect = 2e-12
Identities = 34/107 (31%), Positives = 53/107 (49%), Gaps = 7/107 (6%)
Query: 98 LCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAW 157
LCG V+ + Y CR C I P LC +CF H H + M S GG CDCGD+
Sbjct: 119 LCGLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVM 178
Query: 158 KTGPFCVNHEPGRAGTIKENSRCP-LNEEVIVQARKIFPSVIKYVVE 203
+ FC H+ IK +S P + +++++ + + P I +++
Sbjct: 179 RESGFCKRHQ------IKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQ 219
Score = 63.5 bits (153), Expect = 2e-09
Identities = 57/240 (23%), Positives = 105/240 (43%), Gaps = 27/240 (11%)
Query: 986 KRLREKSCLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFI 1045
KR+ E+ C V + + E K+ +++ + + AR +QK++A+ ++ QK+F+
Sbjct: 1150 KRIIEEICRKVTPPVPPKKVTAAE----KKTLDKEERRQKARERQQKLLAEFASRQKSFM 1205
Query: 1046 ETHKLMYDNTSEMPGKEDSIMEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQ 1105
ET + +++P E + E + + AV D + + GPS ++ +L Q
Sbjct: 1206 ETAMDVDSPENDIP-MEITTAEPQVSEAVYD---CVICGQSGPSSEDRPTGLVVLLQASS 1261
Query: 1106 EV-----KIENNAMVLSACVQKSTALTQHRGKPIELSGEALDPLFMDPDLAY-------- 1152
+ +E + +S Q T + LS L F D
Sbjct: 1262 VLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLS--LLQRYFKDSSCLLAVSIGWEG 1319
Query: 1153 GTYTGSCGHVMHAVCWQKYFEAVQLSSQQRIHVDLFDLESGEYLCPLCKSLCNTVIPIIP 1212
G Y +CGH +H C + Y E+++ + F ++ GE+ CPLC+ N+V+P P
Sbjct: 1320 GVYVQTCGHTLHIDCHKSYMESLRNDQV----LQGFSVDKGEFTCPLCRQFANSVLPCYP 1375
>gi|4826776 Janus kinase 2 [Homo sapiens]
Length = 1132
Score = 37.7 bits (86), Expect = 0.099
Identities = 34/111 (30%), Positives = 54/111 (48%), Gaps = 11/111 (9%)
Query: 774 HLLCIEPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNM 833
H LC E P A+ +N+ N + ++ I+K+ KK G + G+Y L+ S KDFN
Sbjct: 381 HYLCKEVAP-PAVLENIQSNCHGPISMDFAISKL---KKAG-NQTGLYVLRC-SPKDFNK 434
Query: 834 YFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSKVINLLNC 884
YF ++ + + E+ K EN++ L FS + +LLNC
Sbjct: 435 YFLTFAVERENVIEYKHCLITKNENEEYNLSGTK-----KNFSSLKDLLNC 480
>gi|171460956 ubiquitin specific peptidase like 1 [Homo sapiens]
Length = 1092
Score = 37.0 bits (84), Expect = 0.17
Identities = 40/154 (25%), Positives = 66/154 (42%), Gaps = 19/154 (12%)
Query: 723 KTISTKDQDLIKQYNTLIEEMLQVLIYIVGERYVPGVGNVTKEEVTMREIIHLLCIEPMP 782
K++ + +KQ+ T E L+ ER V N+ K+E T
Sbjct: 692 KSVEIEKDAQLKQFLTPKTEQLKP------ERVTSQVSNLKKKETTADSQT------TTS 739
Query: 783 HSAIAKNLPENENNE---TGLENVINKVATFKKPGVSGHGVYELKD--ESLKDFNMYFYH 837
S ++L EN+ + ++ +I++ A+F VS H + D S+K N +
Sbjct: 740 KSLQNQSLKENQKKPFVGSWVKGLISRGASFMPLCVSAHNRNTITDLQPSVKGVNNFGGF 799
Query: 838 YSKTQHSKAEHMQKKRRKQENKDEALPPPP--PP 869
+K + KA H+ KK RK +K + PP PP
Sbjct: 800 KTKGINQKASHVSKKARKSASKPPPISKPPAGPP 833
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 36.2 bits (82), Expect = 0.29
Identities = 49/265 (18%), Positives = 112/265 (42%), Gaps = 59/265 (22%)
Query: 907 TEGMLQMAFHILALGLLEEKQQLQKAPEEEVTFDFYHKASRLGSSAMNIQMLLEKLKGIP 966
T+ ++A + +L+ + + +++ DFY + S L ++ +++ + EKL
Sbjct: 1001 TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLS--- 1057
Query: 967 QLEGQKDMIT---------WILQMFDTVKRLREKS-----------CLIVATTSGSESIK 1006
Q+D+I+ ++Q T K E+ C + +S+K
Sbjct: 1058 --LAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLK 1115
Query: 1007 NDEITHDK------EKAERKRKAEAARLHRQKIMAQMSALQK--NFIETHKLMYDNTSEM 1058
E+ ++K E+ + +++ E +L+ + ++ ++++ N + +L+ E+
Sbjct: 1116 EKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLEL 1175
Query: 1059 PGKEDSI---MEEESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVK---IENN 1112
GK DS+ +E+E KR + + +V +EE+E+K IE
Sbjct: 1176 QGKADSLKAAVEQE---------------KRNQQILKDQVK-----KEEEELKKEFIEKE 1215
Query: 1113 AMVLSACVQKSTALTQHRGKPIELS 1137
A + S +K + +H +L+
Sbjct: 1216 AKLHSEIKEKEVGMKKHEENEAKLT 1240
>gi|154091003 zinc finger protein 470 [Homo sapiens]
Length = 717
Score = 35.0 bits (79), Expect = 0.64
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 14/79 (17%)
Query: 80 GEDP---DICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNH 136
GE P +IC + H G+ L RV +GE Y C++C F+ S H H
Sbjct: 449 GEKPYECNICEKAFSHRGSLTLHQRVH-TGEKPYECKECG---------KAFRQSTHLAH 498
Query: 137 RYKMHTSTGGGFC-DCGDT 154
++HT C +C T
Sbjct: 499 HQRIHTGEKPYECKECSKT 517
>gi|109891938 disks large-associated protein 4 isoform c [Homo
sapiens]
Length = 285
Score = 33.9 bits (76), Expect = 1.4
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 819 GVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSK 877
G ++L S++D +M F + H KA Q ++ K+E PPPP P+ PA SK
Sbjct: 176 GFWDLLQLSIEDISMKF---DELYHLKANSWQLVETPEKRKEEKKPPPPVPK-KPAKSK 230
>gi|34335251 disks large-associated protein 4 isoform b [Homo
sapiens]
Length = 453
Score = 33.9 bits (76), Expect = 1.4
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 819 GVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSK 877
G ++L S++D +M F + H KA Q ++ K+E PPPP P+ PA SK
Sbjct: 344 GFWDLLQLSIEDISMKF---DELYHLKANSWQLVETPEKRKEEKKPPPPVPK-KPAKSK 398
>gi|34335253 disks large-associated protein 4 isoform a [Homo
sapiens]
Length = 989
Score = 33.9 bits (76), Expect = 1.4
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 4/59 (6%)
Query: 819 GVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPPEFCPAFSK 877
G ++L S++D +M F + H KA Q ++ K+E PPPP P+ PA SK
Sbjct: 880 GFWDLLQLSIEDISMKF---DELYHLKANSWQLVETPEKRKEEKKPPPPVPK-KPAKSK 934
>gi|24233517 IKK interacting protein isoform 1 [Homo sapiens]
Length = 377
Score = 33.9 bits (76), Expect = 1.4
Identities = 32/139 (23%), Positives = 62/139 (44%), Gaps = 24/139 (17%)
Query: 947 RLGSSAMNIQMLLEKLKGIPQLEGQKDMITWILQMFDTVKRLREKSCLIVATTSGSESIK 1006
++ S+ I++L E+LK D+ L+ TVKR E+ L V GS++
Sbjct: 187 QINSAEQEIKLLTERLK---------DLEDSTLRNIRTVKRQEEEDLLRVEEQLGSDTKA 237
Query: 1007 NDEITHDKEK------------AERKRKAEAARLHRQKIMAQMSAL---QKNFIETHKLM 1051
+++ ++ ++ + K E + H I + + ++ ++ IET K M
Sbjct: 238 IEKLEEEQHALFARDEDLTNKLSDYEPKVEECKTHLPTIESAIHSVLRVSQDLIETEKKM 297
Query: 1052 YDNTSEMPGKEDSIMEEES 1070
D T +M ED +++ S
Sbjct: 298 EDLTMQMFNMEDDMLKAVS 316
>gi|239749462 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 2 [Homo sapiens]
Length = 2277
Score = 33.5 bits (75), Expect = 1.9
Identities = 14/50 (28%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 110 YSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKT 159
+ CR C + + C +C HK H +K+ ++ +CDC + KT
Sbjct: 673 FECRTCGLLESLCCCTEC-AGVCHKGHDWKLKRTSPTAYCDCWEKCKCKT 721
>gi|113420453 PREDICTED: similar to ubiquitin protein ligase E3
component n-recognin 5 isoform 1 [Homo sapiens]
Length = 2796
Score = 33.5 bits (75), Expect = 1.9
Identities = 14/50 (28%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 110 YSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKT 159
+ CR C + + C +C HK H +K+ ++ +CDC + KT
Sbjct: 1192 FECRTCGLLESLCCCTEC-AGVCHKGHDWKLKRTSPTAYCDCWEKCKCKT 1240
>gi|122937213 zinc finger protein 99 [Homo sapiens]
Length = 1036
Score = 33.1 bits (74), Expect = 2.4
Identities = 22/76 (28%), Positives = 29/76 (38%), Gaps = 3/76 (3%)
Query: 80 GEDPDICLEKLKHSGAFQLCG--RVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHR 137
GE P C E+ K F R+ +G+ Y C +C C C F S H
Sbjct: 940 GEKPYKCEERGKAFSHFSRLTKHRIIHTGKKPYKCEECEKPYKCEECGKAFNQSSHLTQH 999
Query: 138 YKMHTSTGGGFC-DCG 152
+HT C +CG
Sbjct: 1000 KTIHTGGKTYKCEECG 1015
>gi|145580590 hepatitis C virus F protein-binding protein 2 [Homo
sapiens]
Length = 938
Score = 32.7 bits (73), Expect = 3.2
Identities = 28/115 (24%), Positives = 50/115 (43%), Gaps = 10/115 (8%)
Query: 590 GHSLETKSYRVSEDLVS---IHLPLSRTLAGLHVRLSRLGAVSRLHEFVSFEDFQV---E 643
GH + TKS +DL S H L + + + L S LH F F +
Sbjct: 99 GHKIGTKS----KDLPSGPEKHFSWKECLFYIIILVLALLETSLLHHFAGFSQISKSNSQ 154
Query: 644 VLVEYPLRCLVLVAQVVAEMWRRNGLSLISQVFYYQDVKCREEMYDKDIIMLQIG 698
+V Y L L+++ ++ E+ + + FY +DV+ ++K +++IG
Sbjct: 155 AIVGYGLMILLIILWILREIQSVYIIGIFRNPFYPKDVQTVTVFFEKQTRLMKIG 209
>gi|34303932 transmembrane and coiled-coil domains 5A [Homo sapiens]
Length = 288
Score = 32.7 bits (73), Expect = 3.2
Identities = 45/210 (21%), Positives = 89/210 (42%), Gaps = 26/210 (12%)
Query: 946 SRLGSSAMNIQMLLEKLKGIPQL--EGQKDMITWILQMFDTVKRLREKSCLIVATTSGSE 1003
SRL S NI L L+ Q E + ++ I + D ++RL + E
Sbjct: 4 SRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEE 63
Query: 1004 SIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMYDNTSEMPGKED 1063
K + T ++E+A ++ + E ARL R KN H + + ++ K
Sbjct: 64 WEKENRTTMERERALQELEEETARLER-----------KNKTLVHSIT-ELQQKLTRKSQ 111
Query: 1064 SIME-EESTPAVSDYSRIALGPKRGPSVTEKEVLTCILCQEEQEVKI-ENNAMVLSACVQ 1121
I E+S+P G V +++ CQE++ +K+ + A V C
Sbjct: 112 KITNCEQSSPD---------GALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCED 162
Query: 1122 KSTALTQHRGKPIELSGEALDPLFMDPDLA 1151
++ + +++ + ++ E L+ LF++ +++
Sbjct: 163 QALYIKKYQ-ETLKKIEEELEALFLEREVS 191
>gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens]
Length = 256
Score = 32.3 bits (72), Expect = 4.2
Identities = 28/138 (20%), Positives = 65/138 (47%), Gaps = 11/138 (7%)
Query: 982 FDTVKRLREKSCL-----IVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQ 1036
FD +++ R+ L ++ + + + +E+ KE+ E++R A R +Q+I A+
Sbjct: 54 FDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRR---AERAEQQRIRAE 110
Query: 1037 MSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAV-SDYSR--IALGPKRGPSVTEK 1093
++N + K + ED + ++++ ++ ++YS KRG T +
Sbjct: 111 KERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAR 170
Query: 1094 EVLTCILCQEEQEVKIEN 1111
E+ IL + + + I++
Sbjct: 171 EMKKKILAERRKPLNIDH 188
>gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens]
Length = 250
Score = 32.3 bits (72), Expect = 4.2
Identities = 28/138 (20%), Positives = 65/138 (47%), Gaps = 11/138 (7%)
Query: 982 FDTVKRLREKSCL-----IVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQ 1036
FD +++ R+ L ++ + + + +E+ KE+ E++R A R +Q+I A+
Sbjct: 48 FDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRR---AERAEQQRIRAE 104
Query: 1037 MSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAV-SDYSR--IALGPKRGPSVTEK 1093
++N + K + ED + ++++ ++ ++YS KRG T +
Sbjct: 105 KERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAR 164
Query: 1094 EVLTCILCQEEQEVKIEN 1111
E+ IL + + + I++
Sbjct: 165 EMKKKILAERRKPLNIDH 182
>gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens]
Length = 258
Score = 32.3 bits (72), Expect = 4.2
Identities = 28/138 (20%), Positives = 65/138 (47%), Gaps = 11/138 (7%)
Query: 982 FDTVKRLREKSCL-----IVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQ 1036
FD +++ R+ L ++ + + + +E+ KE+ E++R A R +Q+I A+
Sbjct: 56 FDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRR---AERAEQQRIRAE 112
Query: 1037 MSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAV-SDYSR--IALGPKRGPSVTEK 1093
++N + K + ED + ++++ ++ ++YS KRG T +
Sbjct: 113 KERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAR 172
Query: 1094 EVLTCILCQEEQEVKIEN 1111
E+ IL + + + I++
Sbjct: 173 EMKKKILAERRKPLNIDH 190
>gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens]
Length = 250
Score = 32.3 bits (72), Expect = 4.2
Identities = 28/138 (20%), Positives = 65/138 (47%), Gaps = 11/138 (7%)
Query: 982 FDTVKRLREKSCL-----IVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQ 1036
FD +++ R+ L ++ + + + +E+ KE+ E++R A R +Q+I A+
Sbjct: 48 FDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRR---AERAEQQRIRAE 104
Query: 1037 MSALQKNFIETHKLMYDNTSEMPGKEDSIMEEESTPAV-SDYSR--IALGPKRGPSVTEK 1093
++N + K + ED + ++++ ++ ++YS KRG T +
Sbjct: 105 KERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAR 164
Query: 1094 EVLTCILCQEEQEVKIEN 1111
E+ IL + + + I++
Sbjct: 165 EMKKKILAERRKPLNIDH 182
>gi|15147337 ubiquitin protein ligase E3 component n-recognin 5 [Homo
sapiens]
Length = 2799
Score = 32.3 bits (72), Expect = 4.2
Identities = 14/50 (28%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 110 YSCRDCAIDPTCVLCMDCFQDSVHKNHRYKMHTSTGGGFCDCGDTEAWKT 159
+ CR C + + C +C + HK H K+ ++ +CDC + KT
Sbjct: 1194 FECRTCGLLESLCCCTECAR-VCHKGHDCKLKRTSPTAYCDCWEKCKCKT 1242
>gi|86262149 zinc finger and BTB domain containing 7C [Homo sapiens]
Length = 619
Score = 32.3 bits (72), Expect = 4.2
Identities = 14/27 (51%), Positives = 17/27 (62%)
Query: 851 KKRRKQENKDEALPPPPPPEFCPAFSK 877
K R+ +E + E LPPPPPP F F K
Sbjct: 285 KNRKIKEEEKEELPPPPPPPFPNDFFK 311
>gi|90903231 huntingtin [Homo sapiens]
Length = 3144
Score = 32.0 bits (71), Expect = 5.4
Identities = 14/44 (31%), Positives = 25/44 (56%), Gaps = 7/44 (15%)
Query: 826 ESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEALPPPPPP 869
ESLK F + Q + + Q+++++Q+ + + PPPPPP
Sbjct: 12 ESLKSFQ-------QQQQQQQQQQQQQQQQQQQQQQPPPPPPPP 48
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 32.0 bits (71), Expect = 5.4
Identities = 32/132 (24%), Positives = 64/132 (48%), Gaps = 12/132 (9%)
Query: 935 EEVTFDFYHKASRLGSSAMNIQMLLEKL--KGIPQLEGQKDMITWILQMFDTVKRLREKS 992
+ + + KAS+L + N+ LLE+ KGI + KD + Q+ DT + L+E++
Sbjct: 1272 DRLRVELAEKASKLQNELDNVSTLLEEAEKKGI---KFAKDAASLESQLQDTQELLQEET 1328
Query: 993 CLIVATTSGSESIKNDEITHDKEKAERKRKAEAARLHRQKIMAQMSALQKNFIETHKLMY 1052
+ +S ++ ++ E++ + E AR + +K Q+ ALQ +T K +
Sbjct: 1329 RQKLNLSSRIRQLEEEK----NSLQEQQEEEEEARKNLEK---QVLALQSQLADTKKKVD 1381
Query: 1053 DNTSEMPGKEDS 1064
D+ + E++
Sbjct: 1382 DDLGTIESLEEA 1393
>gi|187761324 shootin1 isoform a [Homo sapiens]
Length = 631
Score = 32.0 bits (71), Expect = 5.4
Identities = 25/92 (27%), Positives = 40/92 (43%), Gaps = 13/92 (14%)
Query: 779 EPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHY 838
E + H K L E NET + + N EL +E K+ + Y
Sbjct: 279 ERIQHQQKVKELEEQLENETLHKEIHNLKQQL-----------ELLEEDKKELELK-YQN 326
Query: 839 SKTQHSKAEHMQKKRRKQENKDE-ALPPPPPP 869
S+ + +H + +K+ N+ E ++PPPPPP
Sbjct: 327 SEEKARNLKHSVDELQKRVNQSENSVPPPPPP 358
>gi|50511340 shootin1 isoform b [Homo sapiens]
Length = 456
Score = 32.0 bits (71), Expect = 5.4
Identities = 25/92 (27%), Positives = 40/92 (43%), Gaps = 13/92 (14%)
Query: 779 EPMPHSAIAKNLPENENNETGLENVINKVATFKKPGVSGHGVYELKDESLKDFNMYFYHY 838
E + H K L E NET + + N EL +E K+ + Y
Sbjct: 279 ERIQHQQKVKELEEQLENETLHKEIHNLKQQL-----------ELLEEDKKELELK-YQN 326
Query: 839 SKTQHSKAEHMQKKRRKQENKDE-ALPPPPPP 869
S+ + +H + +K+ N+ E ++PPPPPP
Sbjct: 327 SEEKARNLKHSVDELQKRVNQSENSVPPPPPP 358
>gi|83320068 zinc finger protein 253 [Homo sapiens]
Length = 499
Score = 32.0 bits (71), Expect = 5.4
Identities = 24/81 (29%), Positives = 30/81 (37%), Gaps = 12/81 (14%)
Query: 80 GEDPDICLE--KLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNHR 137
GE P C E K H + ++ +GE Y CR+C F S
Sbjct: 336 GEKPYKCEECGKAFHLSSHLTTHKILHTGEKPYRCRECG---------KAFNHSTTLFSH 386
Query: 138 YKMHTSTGGGFCD-CGDTEAW 157
K+HT CD CG T W
Sbjct: 387 EKIHTGEKPYKCDECGKTFTW 407
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 31.6 bits (70), Expect = 7.1
Identities = 31/146 (21%), Positives = 64/146 (43%), Gaps = 13/146 (8%)
Query: 752 GERYVPGVGNVTKEEVTMREIIHLLCIEPMPHSAIAKNLPENENNET--GLENVINK-VA 808
G+R + + E++ + + ++ E MP +A+ + + + N+ L+ ++K +A
Sbjct: 662 GKRRHSSLPTESDEDIAPAQQVDIVT-EEMPENALPSDEDDKDPNDPYRALDIDLDKPLA 720
Query: 809 TFKKPGVSGHGVYELKDESLKDFNMYFYHYSKTQHSKAEHMQKKRRKQENKDEA------ 862
+K + H E KD M K + + +H +K+R K++ K++
Sbjct: 721 DSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDL 780
Query: 863 ---LPPPPPPEFCPAFSKVINLLNCD 885
L PPP PA + V + C+
Sbjct: 781 DFWLSTTPPPAPAPAPAPVPSTDECE 806
>gi|229577396 zinc finger protein 583 [Homo sapiens]
Length = 569
Score = 31.6 bits (70), Expect = 7.1
Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 13/66 (19%)
Query: 80 GEDP---DICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNH 136
GE P ++C + +SG+ L R+ +GE Y C+D C F+ H H
Sbjct: 488 GEKPYECNVCGKAFSYSGSLTLHQRIH-TGERPYECKD---------CRKSFRQRAHLAH 537
Query: 137 RYKMHT 142
++HT
Sbjct: 538 HERIHT 543
>gi|229577249 zinc finger protein 583 [Homo sapiens]
Length = 569
Score = 31.6 bits (70), Expect = 7.1
Identities = 19/66 (28%), Positives = 30/66 (45%), Gaps = 13/66 (19%)
Query: 80 GEDP---DICLEKLKHSGAFQLCGRVFKSGETTYSCRDCAIDPTCVLCMDCFQDSVHKNH 136
GE P ++C + +SG+ L R+ +GE Y C+D C F+ H H
Sbjct: 488 GEKPYECNVCGKAFSYSGSLTLHQRIH-TGERPYECKD---------CRKSFRQRAHLAH 537
Query: 137 RYKMHT 142
++HT
Sbjct: 538 HERIHT 543
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,045,039
Number of Sequences: 37866
Number of extensions: 3218371
Number of successful extensions: 12242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 4
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 12135
Number of HSP's gapped (non-prelim): 99
length of query: 1749
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1633
effective length of database: 13,855,062
effective search space: 22625316246
effective search space used: 22625316246
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.