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Search of human proteins with 27734911
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27734911 DAZ interacting protein 1-like [Homo sapiens]
(767 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27734911 DAZ interacting protein 1-like [Homo sapiens] 1520 0.0
gi|7662436 DAZ interacting protein 1 isoform 1 [Homo sapiens] 337 2e-92
gi|39725957 DAZ interacting protein 1 isoform 2 [Homo sapiens] 330 2e-90
gi|33946313 ninein isoform 4 [Homo sapiens] 76 1e-13
gi|33946321 ninein isoform 5 [Homo sapiens] 76 1e-13
gi|148536871 ninein isoform 1 [Homo sapiens] 76 1e-13
gi|148536869 ninein isoform 2 [Homo sapiens] 76 1e-13
gi|221139761 zinc finger protein 853 [Homo sapiens] 72 1e-12
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 72 3e-12
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 70 6e-12
gi|92091575 coiled-coil domain containing 57 [Homo sapiens] 70 6e-12
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 70 7e-12
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 70 1e-11
gi|156104874 envoplakin [Homo sapiens] 69 1e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 69 2e-11
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 69 2e-11
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 69 2e-11
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 69 2e-11
gi|21735548 centrosomal protein 2 [Homo sapiens] 69 2e-11
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 69 2e-11
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 69 2e-11
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 69 2e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 68 4e-11
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 68 4e-11
gi|148746195 trichohyalin [Homo sapiens] 68 4e-11
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 67 5e-11
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 67 5e-11
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 67 5e-11
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 67 5e-11
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 67 5e-11
>gi|27734911 DAZ interacting protein 1-like [Homo sapiens]
Length = 767
Score = 1520 bits (3935), Expect = 0.0
Identities = 767/767 (100%), Positives = 767/767 (100%)
Query: 1 MQSPAATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIA 60
MQSPAATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIA
Sbjct: 1 MQSPAATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIA 60
Query: 61 GITFCNLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLG 120
GITFCNLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLG
Sbjct: 61 GITFCNLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLG 120
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF
Sbjct: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
Query: 181 LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAEL 240
LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAEL
Sbjct: 181 LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAEL 240
Query: 241 IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSV 300
IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSV
Sbjct: 241 IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSV 300
Query: 301 MESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQ 360
MESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQ
Sbjct: 301 MESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQ 360
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV
Sbjct: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
Query: 421 DTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGIS 480
DTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGIS
Sbjct: 421 DTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGIS 480
Query: 481 IQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVK 540
IQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVK
Sbjct: 481 IQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVK 540
Query: 541 SQQSALVTREAQPKTRTLQVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPS 600
SQQSALVTREAQPKTRTLQVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPS
Sbjct: 541 SQQSALVTREAQPKTRTLQVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPS 600
Query: 601 STPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDWDWSDTETSEENA 660
STPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDWDWSDTETSEENA
Sbjct: 601 STPPSSGPGMSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDWDWSDTETSEENA 660
Query: 661 QPPGQGSGTLVQSMVKNLEKQLEAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDES 720
QPPGQGSGTLVQSMVKNLEKQLEAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDES
Sbjct: 661 QPPGQGSGTLVQSMVKNLEKQLEAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDES 720
Query: 721 DLEISSLEDLPLDLDQREKPKPLSRSKLPEKFGTGPQSSGQPRVPAW 767
DLEISSLEDLPLDLDQREKPKPLSRSKLPEKFGTGPQSSGQPRVPAW
Sbjct: 721 DLEISSLEDLPLDLDQREKPKPLSRSKLPEKFGTGPQSSGQPRVPAW 767
>gi|7662436 DAZ interacting protein 1 isoform 1 [Homo sapiens]
Length = 848
Score = 337 bits (865), Expect = 2e-92
Identities = 256/774 (33%), Positives = 395/774 (51%), Gaps = 89/774 (11%)
Query: 6 ATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIAGITFC 65
A SGPL P F+F+PR +S+DWRR+S +DVD+VA +DV TLQENI ITFC
Sbjct: 46 APPSAASGPL------PFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFC 99
Query: 66 NLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRG 125
L+ E C C VDP LLK++RLAQ IEYLLH Q+ L++ + LE RL+ S ++
Sbjct: 100 KLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQS 159
Query: 126 QQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHI 185
++ L +QA E+K ++EE +RR+KMIST QQL+++ +Y+ CH CDK FMN FL+ HI
Sbjct: 160 KKLLTKQAGEIKTLKEECKRRKKMIST-QQLMIEAKA-NYYQCHFCDKAFMNQAFLQSHI 217
Query: 186 QRRHAGVAEGGKQKKQEQPVEEVLEE---LRAKLKWTQGELEAQREAERQRQLQEAELIH 242
QRRH + +K Q +E++ E L+ +L+ T+ ELEA A R +E E+
Sbjct: 218 QRRHTEENSHFEYQKNAQ-IEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQK 276
Query: 243 QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ-SHSVM 301
+E + K FD+WKE+E KL E++K+K++F EFK + +NS LE +L +Q S+ +
Sbjct: 277 TKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQI 336
Query: 302 ESKLGSLRD--EESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEEN 359
+S +G+L+D E E+ ++ + + + Q+++W +V+ +H+EH EK L
Sbjct: 337 KSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHI 396
Query: 360 QRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKA 419
++L+ S+ D + + +I L +LQEQ +I +Q + I+ + + I + PK
Sbjct: 397 EKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISE-PKV 455
Query: 420 --------------------------------VDTEEDSPEEEMEDSQDEQHKVLAALRR 447
+ EE E E + + ++ H + AL+
Sbjct: 456 NAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMH-LRKALKS 514
Query: 448 NPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLS 507
N +L K R ++E L EKLE++GI D +GIS L + + +R ++ R+ F
Sbjct: 515 NSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQ 574
Query: 508 LRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVALPSTPA 567
+R L +V+ + +E+ A+ D Q SV SQ L T E PK + LPS
Sbjct: 575 IREFLEHQVSCKIEEK-----ALLSSD-QCSV-SQMDTLSTGEV-PK----MIQLPS--- 619
Query: 568 EPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPSSTPPSSGPGMSTPPFSSEEDSEGDRVQ 627
RQ S + S P + P ++TPPFSSEE+ E D +
Sbjct: 620 ----KNRQLIRQKAVSTDRTSVPKIKKNV--MEDPFPRKSSTITTPPFSSEEEQEDDDLI 673
Query: 628 RVSLQPPKVPSRMVPRPKDDW---------DWSDTETSE-ENAQPPGQGSGTLVQSMVKN 677
R P +P VP P++ D TE SE E+ + +G V++ +
Sbjct: 674 RAYASPGPLP---VPPPQNKGSFGKNTVKSDADGTEGSEIEDTDDSPKPAGVAVKTPTEK 730
Query: 678 LEKQL--EAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSEDESDLEISSLED 729
+EK KP GG + +P ++ K EDE D +ISSLE+
Sbjct: 731 VEKMFPHRKNVNKPVGGTN---VPEMFIKKEELQELKCADVEDE-DWDISSLEE 780
>gi|39725957 DAZ interacting protein 1 isoform 2 [Homo sapiens]
Length = 867
Score = 330 bits (847), Expect = 2e-90
Identities = 256/792 (32%), Positives = 396/792 (50%), Gaps = 106/792 (13%)
Query: 6 ATAEGLSGPLFGAYTFPTFKFQPRHDSMDWRRISTLDVDRVARELDVATLQENIAGITFC 65
A SGPL P F+F+PR +S+DWRR+S +DVD+VA +DV TLQENI ITFC
Sbjct: 46 APPSAASGPL------PFFQFRPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFC 99
Query: 66 NLDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRG 125
L+ E C C VDP LLK++RLAQ IEYLLH Q+ L++ + LE RL+ S ++
Sbjct: 100 KLEDEKCPHCQSGVDPVLLKLIRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQS 159
Query: 126 QQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHI 185
++ L +QA E+K ++EE +RR+KMIST QQL+++ +Y+ CH CDK FMN FL+ HI
Sbjct: 160 KKLLTKQAGEIKTLKEECKRRKKMIST-QQLMIEAKA-NYYQCHFCDKAFMNQAFLQSHI 217
Query: 186 QRRHAGVAEGGKQKKQEQPVEEVLEE---LRAKLKWTQGELEAQREAERQRQLQEAELIH 242
QRRH + +K Q +E++ E L+ +L+ T+ ELEA A R +E E+
Sbjct: 218 QRRHTEENSHFEYQKNAQ-IEKLRSEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQK 276
Query: 243 QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ-SHSVM 301
+E + K FD+WKE+E KL E++K+K++F EFK + +NS LE +L +Q S+ +
Sbjct: 277 TKEEDFLKLFDRWKEEEKEKLVDEMEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQI 336
Query: 302 ESKLGSLRD--EESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEEN 359
+S +G+L+D E E+ ++ + + + Q+++W +V+ +H+EH EK L
Sbjct: 337 KSNIGTLKDAHEFKEDRSPYPQDFHNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHI 396
Query: 360 QRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHK---- 415
++L+ S+ D + + +I L +LQEQ +I +Q + I+ + + I +
Sbjct: 397 EKLRTSMIDDLNASNVFYKKRIEELGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKGN 456
Query: 416 ---------------VP-------------------------------KAVDTEEDSPEE 429
VP + + EE E
Sbjct: 457 PLAWQAFESQPAAPAVPMNAPALHTLETKSSLPMVHEQAFSSHILEPIEELSEEEKGREN 516
Query: 430 EMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLES 489
E + + ++ H + AL+ N +L K R ++E L EKLE++GI D +GIS L +
Sbjct: 517 EQKLNNNKMH-LRKALKSNSSLTKGLRTMVEQNLMEKLETLGINADIRGISSDQLHRVLK 575
Query: 490 LLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTR 549
+ +R ++ R+ F +R L +V+ + +E+ A+ D Q SV SQ L T
Sbjct: 576 SVESERHKQEREIPNFHQIREFLEHQVSCKIEEK-----ALLSSD-QCSV-SQMDTLSTG 628
Query: 550 EAQPKTRTLQVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPSSTPPSSGPG 609
E PK + LPS RQ S + S P + P
Sbjct: 629 EV-PK----MIQLPS-------KNRQLIRQKAVSTDRTSVPKIKKNV--MEDPFPRKSST 674
Query: 610 MSTPPFSSEEDSEGDRVQRVSLQPPKVPSRMVPRPKDDW---------DWSDTETSE-EN 659
++TPPFSSEE+ E D + R P +P VP P++ D TE SE E+
Sbjct: 675 ITTPPFSSEEEQEDDDLIRAYASPGPLP---VPPPQNKGSFGKNTVKSDADGTEGSEIED 731
Query: 660 AQPPGQGSGTLVQSMVKNLEKQL--EAPAKKPAGGVSLFFMPNAGPQRAATPGRKPQLSE 717
+ +G V++ + +EK KP GG + +P ++ K E
Sbjct: 732 TDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTN---VPEMFIKKEELQELKCADVE 788
Query: 718 DESDLEISSLED 729
DE D +ISSLE+
Sbjct: 789 DE-DWDISSLEE 799
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/363 (19%), Positives = 164/363 (45%), Gaps = 47/363 (12%)
Query: 172 DKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER 231
D+T ++ + ++++RH + + +E+ + +L+ ++ QG+ +EA
Sbjct: 647 DETVVSCKKAQENMKQRH---------ENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 697
Query: 232 QRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEK 291
+ + E +++++ K E +K QE +L E++ +L + ++ E +
Sbjct: 698 EATCRHEE--EKKQLQVKLEEEKTHLQEKLRLQHEMELKARL--------TQAQASFERE 747
Query: 292 LRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE 351
LQS + E K+ L +E E++ ++ +L +L EK ++K E ++++ E H+ + E
Sbjct: 748 REGLQSSAWTEEKVRGL-TQELEQFHQE--QLTSLVEKHTLEKEELRKELLEKHQRELQE 804
Query: 352 KKELQE-----ENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLS 406
+E E +++A D +K + + + +L + +++ + + Q+ +S
Sbjct: 805 GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS-- 862
Query: 407 LRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEK 466
+ E+D +E ++Q+ + L + +L R +LE T +E
Sbjct: 863 ------------QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 910
Query: 467 LESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQEN 526
L SM + + Q L+ LE L V Q++ + L L+ +E+ R + +
Sbjct: 911 LNSMVVERQ------QLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQA 964
Query: 527 GAA 529
GA+
Sbjct: 965 GAS 967
Score = 66.6 bits (161), Expect = 8e-11
Identities = 114/529 (21%), Positives = 216/529 (40%), Gaps = 98/529 (18%)
Query: 85 KVLRLAQLIIEYLLHCQDCL-SASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREES 143
K+ +L + +++ C CL AS+ LE ++ Q + +E + + V EE
Sbjct: 1337 KIEKLQESVVQ---RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1393
Query: 144 RRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ 203
++ + + QLL + H H +T ++ + G + K +
Sbjct: 1394 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQH 1453
Query: 204 PVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAE--LIHQREIEAKKEFDKWKEQEWT 261
+ + EL ELE + E R+L+E L+ Q+++ + E KE+E
Sbjct: 1454 --QATIAEL---------ELEKTKLQELTRKLKERVTILVKQKDVLSHGE----KEEELK 1498
Query: 262 KLY-------GEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEES 313
+ E+ + +L E + + ++NS L ++ L + S+ KLG+L +
Sbjct: 1499 AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE 1558
Query: 314 EEWLR------QARELQALREKTEIQKTEWKRKVK-------ELHEEHMAEKKELQEENQ 360
E W + + +Q + E + Q +E K K + EL +++ +++LQE NQ
Sbjct: 1559 EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQ 1618
Query: 361 RLQASLSQDQK----------------------KAAAQSQCQISTLRAQLQE---QARII 395
RL L Q +K + QS +S+L A+L E Q I+
Sbjct: 1619 RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1678
Query: 396 ASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHF 455
+ +++ L K++ +H+ P D D Q K+ + L N LLK
Sbjct: 1679 QQENHLLKD-ELEKMKQLHRCP---------------DLSDFQQKISSVLSYNEKLLKE- 1721
Query: 456 RPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLV-- 513
++ L E+L S + K AK ++ + +++EQK+ + + SL+ +LV
Sbjct: 1722 ----KEALSEELNSC-VDKLAKSSLLE-----HRIATMKQEQKSWE-HQSASLKSQLVAS 1770
Query: 514 -KEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVA 561
++V + Q +S+ V Q+ + +E + LQ A
Sbjct: 1771 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1819
Score = 48.5 bits (114), Expect = 2e-05
Identities = 101/483 (20%), Positives = 191/483 (39%), Gaps = 62/483 (12%)
Query: 67 LDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQ 126
L +C + +P + AL + + + E L C+ S V+ LEA L Q Q
Sbjct: 1620 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ 1679
Query: 127 QELGRQADELKGVREESRR------RRKMISTL---QQLLMQTGTHSYHTCHLCDKTFMN 177
QE DEL+ +++ R ++K+ S L ++LL + S DK +
Sbjct: 1680 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKS 1739
Query: 178 ATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQE 237
+ ++ R A + + +QK E + +L A + Q + + Q +
Sbjct: 1740 SL-----LEHRIATMKQ--EQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK 1792
Query: 238 AEL-IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ 296
++L + Q+E EA K QE L+ ++ W +A S L + + L
Sbjct: 1793 SDLRVTQQEKEALK-------QEVMSLHKQLQNAGGKSWAP--EIATHPSGLHNQQKRLS 1843
Query: 297 SHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKEL-------HEEHM 349
KL L +EE + ++ LQ + + T+ + T + KV++L H++H+
Sbjct: 1844 W-----DKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1898
Query: 350 ----------AEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQA---RIIA 396
EK L+ E + Q S +K + + + L+ + + +
Sbjct: 1899 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1958
Query: 397 SQEEMIQSLSLRKVEGIHKVPKAVD----TEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
E++++ LR P A D ++ P E Q ++L A R N
Sbjct: 1959 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERIN---- 2014
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQR---EQKARKFSEFLSLR 509
+H + LE+ E G ++ + + + +E L++ + ++K + E +SL
Sbjct: 2015 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLP 2074
Query: 510 GKL 512
G L
Sbjct: 2075 GHL 2077
Score = 37.0 bits (84), Expect = 0.069
Identities = 82/398 (20%), Positives = 162/398 (40%), Gaps = 57/398 (14%)
Query: 225 AQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK-NVAK 283
A +AE + L+ + + + + + + + DK E+ + + E+D + N+ K
Sbjct: 369 ASFKAEIRHLLERVDQVVREKEKLRSDLDK-AEKLKSLMASEVDDHHAAIERRNEYNLRK 427
Query: 284 QNSTLEEKLRALQSHSVME-----SKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ +E++ AL++ E + G R E +E + E +R++ + E
Sbjct: 428 LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 487
Query: 339 RKVKELHE--EHMAEKKELQEENQR-LQASLSQ---DQKKAAAQSQCQ---ISTLRAQLQ 389
R EL E E +AE + L + QR L+ L++ D ++A+ Q ++ +R + +
Sbjct: 488 RLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 547
Query: 390 EQARIIASQEEMIQS-LSLRKVEG-IHKVPKAVDTEEDSPEEEMEDSQD--EQHKVLAAL 445
Q R++ Q + +QS L + +G + ++P ++SP EE+E + E L +
Sbjct: 548 RQCRVLQDQVDELQSELEEYRAQGRVLRLPL-----KNSPSEEVEANSGGIEPEHGLGSE 602
Query: 446 RRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLE-SLLRVQREQKARKFSE 504
NP + ++ + ++E+ H + LR++ E K R + +
Sbjct: 603 ECNPLNMSIEAELVIEQMKEQ------------------HHRDICCLRLELEDKVRHYEK 644
Query: 505 FLSLRGKLVKEVTSRAKERQENGA------------AVSQPDGQPSVKSQQSALVTREAQ 552
L K+ K+R EN +++ GQ +V + T +
Sbjct: 645 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 704
Query: 553 PKTRTLQVALPSTPAEPPPPTRQSHGSH-GSSLTQVSA 589
+ + LQV L R H + LTQ A
Sbjct: 705 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQA 742
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/363 (19%), Positives = 164/363 (45%), Gaps = 47/363 (12%)
Query: 172 DKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER 231
D+T ++ + ++++RH + + +E+ + +L+ ++ QG+ +EA
Sbjct: 641 DETVVSCKKAQENMKQRH---------ENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 691
Query: 232 QRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEK 291
+ + E +++++ K E +K QE +L E++ +L + ++ E +
Sbjct: 692 EATCRHEE--EKKQLQVKLEEEKTHLQEKLRLQHEMELKARL--------TQAQASFERE 741
Query: 292 LRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE 351
LQS + E K+ L +E E++ ++ +L +L EK ++K E ++++ E H+ + E
Sbjct: 742 REGLQSSAWTEEKVRGL-TQELEQFHQE--QLTSLVEKHTLEKEELRKELLEKHQRELQE 798
Query: 352 KKELQE-----ENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLS 406
+E E +++A D +K + + + +L + +++ + + Q+ +S
Sbjct: 799 GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS-- 856
Query: 407 LRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEK 466
+ E+D +E ++Q+ + L + +L R +LE T +E
Sbjct: 857 ------------QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 467 LESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQEN 526
L SM + + Q L+ LE L V Q++ + L L+ +E+ R + +
Sbjct: 905 LNSMVVERQ------QLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQA 958
Query: 527 GAA 529
GA+
Sbjct: 959 GAS 961
Score = 66.6 bits (161), Expect = 8e-11
Identities = 114/529 (21%), Positives = 216/529 (40%), Gaps = 98/529 (18%)
Query: 85 KVLRLAQLIIEYLLHCQDCL-SASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREES 143
K+ +L + +++ C CL AS+ LE ++ Q + +E + + V EE
Sbjct: 1331 KIEKLQESVVQ---RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1387
Query: 144 RRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ 203
++ + + QLL + H H +T ++ + G + K +
Sbjct: 1388 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQH 1447
Query: 204 PVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAE--LIHQREIEAKKEFDKWKEQEWT 261
+ + EL ELE + E R+L+E L+ Q+++ + E KE+E
Sbjct: 1448 --QATIAEL---------ELEKTKLQELTRKLKERVTILVKQKDVLSHGE----KEEELK 1492
Query: 262 KLY-------GEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEES 313
+ E+ + +L E + + ++NS L ++ L + S+ KLG+L +
Sbjct: 1493 AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE 1552
Query: 314 EEWLR------QARELQALREKTEIQKTEWKRKVK-------ELHEEHMAEKKELQEENQ 360
E W + + +Q + E + Q +E K K + EL +++ +++LQE NQ
Sbjct: 1553 EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQ 1612
Query: 361 RLQASLSQDQK----------------------KAAAQSQCQISTLRAQLQE---QARII 395
RL L Q +K + QS +S+L A+L E Q I+
Sbjct: 1613 RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1672
Query: 396 ASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHF 455
+ +++ L K++ +H+ P D D Q K+ + L N LLK
Sbjct: 1673 QQENHLLKD-ELEKMKQLHRCP---------------DLSDFQQKISSVLSYNEKLLKE- 1715
Query: 456 RPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLV-- 513
++ L E+L S + K AK ++ + +++EQK+ + + SL+ +LV
Sbjct: 1716 ----KEALSEELNSC-VDKLAKSSLLE-----HRIATMKQEQKSWE-HQSASLKSQLVAS 1764
Query: 514 -KEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVA 561
++V + Q +S+ V Q+ + +E + LQ A
Sbjct: 1765 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1813
Score = 48.5 bits (114), Expect = 2e-05
Identities = 101/483 (20%), Positives = 191/483 (39%), Gaps = 62/483 (12%)
Query: 67 LDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQ 126
L +C + +P + AL + + + E L C+ S V+ LEA L Q Q
Sbjct: 1614 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ 1673
Query: 127 QELGRQADELKGVREESRR------RRKMISTL---QQLLMQTGTHSYHTCHLCDKTFMN 177
QE DEL+ +++ R ++K+ S L ++LL + S DK +
Sbjct: 1674 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKS 1733
Query: 178 ATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQE 237
+ ++ R A + + +QK E + +L A + Q + + Q +
Sbjct: 1734 SL-----LEHRIATMKQ--EQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK 1786
Query: 238 AEL-IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ 296
++L + Q+E EA K QE L+ ++ W +A S L + + L
Sbjct: 1787 SDLRVTQQEKEALK-------QEVMSLHKQLQNAGGKSWAP--EIATHPSGLHNQQKRLS 1837
Query: 297 SHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKEL-------HEEHM 349
KL L +EE + ++ LQ + + T+ + T + KV++L H++H+
Sbjct: 1838 W-----DKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
Query: 350 ----------AEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQA---RIIA 396
EK L+ E + Q S +K + + + L+ + + +
Sbjct: 1893 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1952
Query: 397 SQEEMIQSLSLRKVEGIHKVPKAVD----TEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
E++++ LR P A D ++ P E Q ++L A R N
Sbjct: 1953 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERIN---- 2008
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQR---EQKARKFSEFLSLR 509
+H + LE+ E G ++ + + + +E L++ + ++K + E +SL
Sbjct: 2009 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQVSLP 2068
Query: 510 GKL 512
G L
Sbjct: 2069 GHL 2071
Score = 37.0 bits (84), Expect = 0.069
Identities = 82/398 (20%), Positives = 162/398 (40%), Gaps = 57/398 (14%)
Query: 225 AQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK-NVAK 283
A +AE + L+ + + + + + + + DK E+ + + E+D + N+ K
Sbjct: 363 ASFKAEIRHLLERVDQVVREKEKLRSDLDK-AEKLKSLMASEVDDHHAAIERRNEYNLRK 421
Query: 284 QNSTLEEKLRALQSHSVME-----SKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ +E++ AL++ E + G R E +E + E +R++ + E
Sbjct: 422 LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 481
Query: 339 RKVKELHE--EHMAEKKELQEENQR-LQASLSQ---DQKKAAAQSQCQ---ISTLRAQLQ 389
R EL E E +AE + L + QR L+ L++ D ++A+ Q ++ +R + +
Sbjct: 482 RLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 541
Query: 390 EQARIIASQEEMIQS-LSLRKVEG-IHKVPKAVDTEEDSPEEEMEDSQD--EQHKVLAAL 445
Q R++ Q + +QS L + +G + ++P ++SP EE+E + E L +
Sbjct: 542 RQCRVLQDQVDELQSELEEYRAQGRVLRLPL-----KNSPSEEVEANSGGIEPEHGLGSE 596
Query: 446 RRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLE-SLLRVQREQKARKFSE 504
NP + ++ + ++E+ H + LR++ E K R + +
Sbjct: 597 ECNPLNMSIEAELVIEQMKEQ------------------HHRDICCLRLELEDKVRHYEK 638
Query: 505 FLSLRGKLVKEVTSRAKERQENGA------------AVSQPDGQPSVKSQQSALVTREAQ 552
L K+ K+R EN +++ GQ +V + T +
Sbjct: 639 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 698
Query: 553 PKTRTLQVALPSTPAEPPPPTRQSHGSH-GSSLTQVSA 589
+ + LQV L R H + LTQ A
Sbjct: 699 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQA 736
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/363 (19%), Positives = 164/363 (45%), Gaps = 47/363 (12%)
Query: 172 DKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER 231
D+T ++ + ++++RH + + +E+ + +L+ ++ QG+ +EA
Sbjct: 641 DETVVSCKKAQENMKQRH---------ENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 691
Query: 232 QRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEK 291
+ + E +++++ K E +K QE +L E++ +L + ++ E +
Sbjct: 692 EATCRHEE--EKKQLQVKLEEEKTHLQEKLRLQHEMELKARL--------TQAQASFERE 741
Query: 292 LRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE 351
LQS + E K+ L +E E++ ++ +L +L EK ++K E ++++ E H+ + E
Sbjct: 742 REGLQSSAWTEEKVRGL-TQELEQFHQE--QLTSLVEKHTLEKEELRKELLEKHQRELQE 798
Query: 352 KKELQE-----ENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLS 406
+E E +++A D +K + + + +L + +++ + + Q+ +S
Sbjct: 799 GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS-- 856
Query: 407 LRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEK 466
+ E+D +E ++Q+ + L + +L R +LE T +E
Sbjct: 857 ------------QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 467 LESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQEN 526
L SM + + Q L+ LE L V Q++ + L L+ +E+ R + +
Sbjct: 905 LNSMVVERQ------QLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQA 958
Query: 527 GAA 529
GA+
Sbjct: 959 GAS 961
Score = 66.6 bits (161), Expect = 8e-11
Identities = 114/529 (21%), Positives = 216/529 (40%), Gaps = 98/529 (18%)
Query: 85 KVLRLAQLIIEYLLHCQDCL-SASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREES 143
K+ +L + +++ C CL AS+ LE ++ Q + +E + + V EE
Sbjct: 1331 KIEKLQESVVQ---RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1387
Query: 144 RRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ 203
++ + + QLL + H H +T ++ + G + K +
Sbjct: 1388 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQH 1447
Query: 204 PVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAE--LIHQREIEAKKEFDKWKEQEWT 261
+ + EL ELE + E R+L+E L+ Q+++ + E KE+E
Sbjct: 1448 --QATIAEL---------ELEKTKLQELTRKLKERVTILVKQKDVLSHGE----KEEELK 1492
Query: 262 KLY-------GEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEES 313
+ E+ + +L E + + ++NS L ++ L + S+ KLG+L +
Sbjct: 1493 AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE 1552
Query: 314 EEWLR------QARELQALREKTEIQKTEWKRKVK-------ELHEEHMAEKKELQEENQ 360
E W + + +Q + E + Q +E K K + EL +++ +++LQE NQ
Sbjct: 1553 EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQ 1612
Query: 361 RLQASLSQDQK----------------------KAAAQSQCQISTLRAQLQE---QARII 395
RL L Q +K + QS +S+L A+L E Q I+
Sbjct: 1613 RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1672
Query: 396 ASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHF 455
+ +++ L K++ +H+ P D D Q K+ + L N LLK
Sbjct: 1673 QQENHLLKD-ELEKMKQLHRCP---------------DLSDFQQKISSVLSYNEKLLKE- 1715
Query: 456 RPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLV-- 513
++ L E+L S + K AK ++ + +++EQK+ + + SL+ +LV
Sbjct: 1716 ----KEALSEELNSC-VDKLAKSSLLE-----HRIATMKQEQKSWE-HQSASLKSQLVAS 1764
Query: 514 -KEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVA 561
++V + Q +S+ V Q+ + +E + LQ A
Sbjct: 1765 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1813
Score = 43.5 bits (101), Expect = 7e-04
Identities = 94/458 (20%), Positives = 177/458 (38%), Gaps = 59/458 (12%)
Query: 67 LDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQ 126
L +C + +P + AL + + + E L C+ S V+ LEA L Q Q
Sbjct: 1614 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ 1673
Query: 127 QELGRQADELKGVREESRR------RRKMISTL---QQLLMQTGTHSYHTCHLCDKTFMN 177
QE DEL+ +++ R ++K+ S L ++LL + S DK +
Sbjct: 1674 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKS 1733
Query: 178 ATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQE 237
+ ++ R A + + +QK E + +L A + Q + + Q +
Sbjct: 1734 SL-----LEHRIATMKQ--EQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK 1786
Query: 238 AEL-IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ 296
++L + Q+E EA K QE L+ ++ W +A S L + + L
Sbjct: 1787 SDLRVTQQEKEALK-------QEVMSLHKQLQNAGGKSWAP--EIATHPSGLHNQQKRLS 1837
Query: 297 SHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKEL-------HEEHM 349
KL L +EE + ++ LQ + + T+ + T + KV++L H++H+
Sbjct: 1838 W-----DKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
Query: 350 ----------AEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQA---RIIA 396
EK L+ E + Q S +K + + + L+ + + +
Sbjct: 1893 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1952
Query: 397 SQEEMIQSLSLRKVEGIHKVPKAVD----TEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
E++++ LR P A D ++ P E Q ++L A R N
Sbjct: 1953 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERIN---- 2008
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESL 490
+H + LE+ E + + + + + R + L
Sbjct: 2009 QHLQEELENRTSETNTPQALLPEQRAVHADSYRRIGHL 2046
Score = 37.0 bits (84), Expect = 0.069
Identities = 82/398 (20%), Positives = 162/398 (40%), Gaps = 57/398 (14%)
Query: 225 AQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK-NVAK 283
A +AE + L+ + + + + + + + DK E+ + + E+D + N+ K
Sbjct: 363 ASFKAEIRHLLERVDQVVREKEKLRSDLDK-AEKLKSLMASEVDDHHAAIERRNEYNLRK 421
Query: 284 QNSTLEEKLRALQSHSVME-----SKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ +E++ AL++ E + G R E +E + E +R++ + E
Sbjct: 422 LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 481
Query: 339 RKVKELHE--EHMAEKKELQEENQR-LQASLSQ---DQKKAAAQSQCQ---ISTLRAQLQ 389
R EL E E +AE + L + QR L+ L++ D ++A+ Q ++ +R + +
Sbjct: 482 RLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 541
Query: 390 EQARIIASQEEMIQS-LSLRKVEG-IHKVPKAVDTEEDSPEEEMEDSQD--EQHKVLAAL 445
Q R++ Q + +QS L + +G + ++P ++SP EE+E + E L +
Sbjct: 542 RQCRVLQDQVDELQSELEEYRAQGRVLRLPL-----KNSPSEEVEANSGGIEPEHGLGSE 596
Query: 446 RRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLE-SLLRVQREQKARKFSE 504
NP + ++ + ++E+ H + LR++ E K R + +
Sbjct: 597 ECNPLNMSIEAELVIEQMKEQ------------------HHRDICCLRLELEDKVRHYEK 638
Query: 505 FLSLRGKLVKEVTSRAKERQENGA------------AVSQPDGQPSVKSQQSALVTREAQ 552
L K+ K+R EN +++ GQ +V + T +
Sbjct: 639 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 698
Query: 553 PKTRTLQVALPSTPAEPPPPTRQSHGSH-GSSLTQVSA 589
+ + LQV L R H + LTQ A
Sbjct: 699 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQA 736
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 75.9 bits (185), Expect = 1e-13
Identities = 72/363 (19%), Positives = 164/363 (45%), Gaps = 47/363 (12%)
Query: 172 DKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER 231
D+T ++ + ++++RH + + +E+ + +L+ ++ QG+ +EA
Sbjct: 641 DETVVSCKKAQENMKQRH---------ENETHTLEKQISDLKNEIAELQGQAAVLKEAHH 691
Query: 232 QRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEK 291
+ + E +++++ K E +K QE +L E++ +L + ++ E +
Sbjct: 692 EATCRHEE--EKKQLQVKLEEEKTHLQEKLRLQHEMELKARL--------TQAQASFERE 741
Query: 292 LRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE 351
LQS + E K+ L +E E++ ++ +L +L EK ++K E ++++ E H+ + E
Sbjct: 742 REGLQSSAWTEEKVRGL-TQELEQFHQE--QLTSLVEKHTLEKEELRKELLEKHQRELQE 798
Query: 352 KKELQE-----ENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLS 406
+E E +++A D +K + + + +L + +++ + + Q+ +S
Sbjct: 799 GREKMETECNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKS-- 856
Query: 407 LRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEK 466
+ E+D +E ++Q+ + L + +L R +LE T +E
Sbjct: 857 ------------QWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEH 904
Query: 467 LESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQEN 526
L SM + + Q L+ LE L V Q++ + L L+ +E+ R + +
Sbjct: 905 LNSMVVERQ------QLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQA 958
Query: 527 GAA 529
GA+
Sbjct: 959 GAS 961
Score = 66.6 bits (161), Expect = 8e-11
Identities = 114/529 (21%), Positives = 216/529 (40%), Gaps = 98/529 (18%)
Query: 85 KVLRLAQLIIEYLLHCQDCL-SASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREES 143
K+ +L + +++ C CL AS+ LE ++ Q + +E + + V EE
Sbjct: 1331 KIEKLQESVVQ---RCDCCLWEASLENLEIEPDGNILQLNQTLEECVPRVRSVHHVIEEC 1387
Query: 144 RRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ 203
++ + + QLL + H H +T ++ + G + K +
Sbjct: 1388 KQENQYLEGNTQLLEKVKAHEIAWLHGTIQTHQERPRVQNQVILEENTTLLGFQDKHFQH 1447
Query: 204 PVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAE--LIHQREIEAKKEFDKWKEQEWT 261
+ + EL ELE + E R+L+E L+ Q+++ + E KE+E
Sbjct: 1448 --QATIAEL---------ELEKTKLQELTRKLKERVTILVKQKDVLSHGE----KEEELK 1492
Query: 262 KLY-------GEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEES 313
+ E+ + +L E + + ++NS L ++ L + S+ KLG+L +
Sbjct: 1493 AMMHDLQITCSEMQQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQE 1552
Query: 314 EEWLR------QARELQALREKTEIQKTEWKRKVK-------ELHEEHMAEKKELQEENQ 360
E W + + +Q + E + Q +E K K + EL +++ +++LQE NQ
Sbjct: 1553 EMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQ 1612
Query: 361 RLQASLSQDQK----------------------KAAAQSQCQISTLRAQLQE---QARII 395
RL L Q +K + QS +S+L A+L E Q I+
Sbjct: 1613 RLTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIV 1672
Query: 396 ASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHF 455
+ +++ L K++ +H+ P D D Q K+ + L N LLK
Sbjct: 1673 QQENHLLKD-ELEKMKQLHRCP---------------DLSDFQQKISSVLSYNEKLLKE- 1715
Query: 456 RPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLV-- 513
++ L E+L S + K AK ++ + +++EQK+ + + SL+ +LV
Sbjct: 1716 ----KEALSEELNSC-VDKLAKSSLLE-----HRIATMKQEQKSWE-HQSASLKSQLVAS 1764
Query: 514 -KEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVA 561
++V + Q +S+ V Q+ + +E + LQ A
Sbjct: 1765 QEKVQNLEDTVQNVNLQMSRMKSDLRVTQQEKEALKQEVMSLHKQLQNA 1813
Score = 45.4 bits (106), Expect = 2e-04
Identities = 106/542 (19%), Positives = 208/542 (38%), Gaps = 62/542 (11%)
Query: 67 LDREVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQ 126
L +C + +P + AL + + + E L C+ S V+ LEA L Q Q
Sbjct: 1614 LTEMLCQKEKEPGNSALEEREQEKFNLKEELERCKVQSSTLVSSLEAELSEVKIQTHIVQ 1673
Query: 127 QELGRQADELKGVREESRR------RRKMISTL---QQLLMQTGTHSYHTCHLCDKTFMN 177
QE DEL+ +++ R ++K+ S L ++LL + S DK +
Sbjct: 1674 QENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEKEALSEELNSCVDKLAKS 1733
Query: 178 ATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQE 237
+ ++ R A + + +QK E + +L A + Q + + Q +
Sbjct: 1734 SL-----LEHRIATMKQ--EQKSWEHQSASLKSQLVASQEKVQNLEDTVQNVNLQMSRMK 1786
Query: 238 AEL-IHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ 296
++L + Q+E EA K QE L+ ++ W +A S L + + L
Sbjct: 1787 SDLRVTQQEKEALK-------QEVMSLHKQLQNAGGKSWAP--EIATHPSGLHNQQKRLS 1837
Query: 297 SHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKEL-------HEEHM 349
KL L +EE + ++ LQ + + T+ + T + KV++L H++H+
Sbjct: 1838 W-----DKLDHLMNEEQQLLWQENERLQTMVQNTKAELTHSREKVRQLESNLLPKHQKHL 1892
Query: 350 ----------AEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQA---RIIA 396
EK L+ E + Q S +K + + + L+ + + +
Sbjct: 1893 NPSGTMNPTEQEKLSLKRECDQFQKEQSPANRKVSQMNSLEQELETIHLENEGLKKKQVK 1952
Query: 397 SQEEMIQSLSLRKVEGIHKVPKAVD----TEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
E++++ LR P A D ++ P E Q ++L A R N
Sbjct: 1953 LDEQLMEMQHLRSTATPSPSPHAWDLQLLQQQACPMVPREQFLQLQRQLLQAERIN---- 2008
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQR---EQKARKFSEFLSLR 509
+H + LE+ E G ++ + + + +E L++ + ++K + E L
Sbjct: 2009 QHLQEELENRTSETNTPQGNQEQLVTVMEERMIEVEQKLKLVKRLLQEKVNQLKEQLCKN 2068
Query: 510 GKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVALPSTPAEP 569
K V E + A+ + + +++ L+ + + ++ P+
Sbjct: 2069 TKADAMVKDLYVENAQLLKALEVTEQRQKTAEKKNYLLEEKIASLSNIVRNLTPAPLTST 2128
Query: 570 PP 571
PP
Sbjct: 2129 PP 2130
Score = 37.0 bits (84), Expect = 0.069
Identities = 82/398 (20%), Positives = 162/398 (40%), Gaps = 57/398 (14%)
Query: 225 AQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK-NVAK 283
A +AE + L+ + + + + + + + DK E+ + + E+D + N+ K
Sbjct: 363 ASFKAEIRHLLERVDQVVREKEKLRSDLDK-AEKLKSLMASEVDDHHAAIERRNEYNLRK 421
Query: 284 QNSTLEEKLRALQSHSVME-----SKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ +E++ AL++ E + G R E +E + E +R++ + E
Sbjct: 422 LDEEYKERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENS 481
Query: 339 RKVKELHE--EHMAEKKELQEENQR-LQASLSQ---DQKKAAAQSQCQ---ISTLRAQLQ 389
R EL E E +AE + L + QR L+ L++ D ++A+ Q ++ +R + +
Sbjct: 482 RLENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYE 541
Query: 390 EQARIIASQEEMIQS-LSLRKVEG-IHKVPKAVDTEEDSPEEEMEDSQD--EQHKVLAAL 445
Q R++ Q + +QS L + +G + ++P ++SP EE+E + E L +
Sbjct: 542 RQCRVLQDQVDELQSELEEYRAQGRVLRLPL-----KNSPSEEVEANSGGIEPEHGLGSE 596
Query: 446 RRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLE-SLLRVQREQKARKFSE 504
NP + ++ + ++E+ H + LR++ E K R + +
Sbjct: 597 ECNPLNMSIEAELVIEQMKEQ------------------HHRDICCLRLELEDKVRHYEK 638
Query: 505 FLSLRGKLVKEVTSRAKERQENGA------------AVSQPDGQPSVKSQQSALVTREAQ 552
L K+ K+R EN +++ GQ +V + T +
Sbjct: 639 QLDETVVSCKKAQENMKQRHENETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHE 698
Query: 553 PKTRTLQVALPSTPAEPPPPTRQSHGSH-GSSLTQVSA 589
+ + LQV L R H + LTQ A
Sbjct: 699 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQA 736
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 72.4 bits (176), Expect = 1e-12
Identities = 83/414 (20%), Positives = 184/414 (44%), Gaps = 37/414 (8%)
Query: 190 AGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER-QRQLQEAELIHQREIEA 248
+G + G + +++E+P E R + G E E QR+LQ +L Q E +
Sbjct: 43 SGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQ 102
Query: 249 KKEFDKWKE-------QEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKL----RALQS 297
+ + ++ ++ Q+ + G+ +L +L ++ ++V Q E +L + LQ
Sbjct: 103 QPQHEQLQQPQPHLELQQQPQQDGQ-QQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQP 161
Query: 298 HSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQE 357
V E + L+ ++ + +QA+E Q L+++ ++Q+ ++++ + +E + +++ LQ+
Sbjct: 162 QQVQEQQ--RLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQ 219
Query: 358 ENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP 417
+ Q Q Q Q++ Q Q + + QLQ+Q ++ Q+ +Q L + + +
Sbjct: 220 QEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQ--LLQQQQAQLQQQLLEQQQAQLQQQ 277
Query: 418 KAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAK 477
+ +E +++ + +Q + L + P L+ E+ E +LE M + ++
Sbjct: 278 LLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEP-----EEEEEVELELMPVDLGSE 332
Query: 478 GISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQP 537
Q + LE ++R+Q+ R+ L+ KL +E+ ++ ++ Q
Sbjct: 333 QELEQQRQELERQQELERQQEQRQ------LQLKLQEELQQLEQQLEQQ---------QQ 377
Query: 538 SVKSQQSALVTREAQPKTRTLQVALPSTPAEPPPPTRQSHGSHGSSLTQVSAPA 591
++ Q+ L + + +V L TP +P + G APA
Sbjct: 378 QLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLELVPAAGGGGAAVPGAPA 431
Score = 61.2 bits (147), Expect = 3e-09
Identities = 64/321 (19%), Positives = 146/321 (45%), Gaps = 23/321 (7%)
Query: 104 LSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTH 163
+SA V E +T GQ++ Q+L +Q + + + E ++ + LQQ Q G
Sbjct: 69 VSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQ 128
Query: 164 SYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGEL 223
++ L+ +Q H +Q +++Q +++ E+L+ + Q L
Sbjct: 129 QLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVL 188
Query: 224 EAQRE-----------AERQRQLQEAELIHQREIEAKKEFDKWKE----QEWTKLYGEID 268
+ Q + ++Q QLQ+ +L+ Q+E +++F + +E Q+ L +
Sbjct: 189 QQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQG 248
Query: 269 KLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARE--LQAL 326
+L++ + + Q LE++ LQ +++ + L+ ++ ++ L+Q +E Q
Sbjct: 249 QLQQQLLQQ-QQAQLQQQLLEQQQAQLQQQLLLQQQ-EQLQQQQQQQLLQQQQEQLQQQQ 306
Query: 327 REKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRL----QASLSQDQKKAAAQSQCQIS 382
+ ++ E + EL + ++EL+++ Q L + Q+Q++ + Q ++
Sbjct: 307 LQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQ 366
Query: 383 TLRAQLQEQARIIASQEEMIQ 403
L QL++Q + + QE ++
Sbjct: 367 QLEQQLEQQQQQLEQQEVQLE 387
Score = 46.6 bits (109), Expect = 9e-05
Identities = 62/299 (20%), Positives = 141/299 (47%), Gaps = 44/299 (14%)
Query: 97 LLHCQDCLSASVAQLEARL---QTSLGQQQRGQQELGRQADEL-KGVREESRRRRKMIST 152
L+H Q L Q + RL Q L QQ +Q++ +Q ++L + V+E+ +++
Sbjct: 152 LMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQL 211
Query: 153 LQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEEL 212
QQ L+Q E +Q++ +Q E++ ++
Sbjct: 212 QQQQLLQQ--------------------------------QEQLQQQQFQQQQEQLQQQQ 239
Query: 213 RAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKK 272
+ L QG+L+ Q ++Q QLQ+ +L+ Q++ + +++ ++++ + + +L +
Sbjct: 240 QLLLLQQQGQLQQQLLQQQQAQLQQ-QLLEQQQAQLQQQLLLQQQEQLQQ--QQQQQLLQ 296
Query: 273 LFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRD-EESEEWLRQARELQALREKTE 331
++ + Q LE + +M LGS ++ E+ + L + +EL+ +E+ +
Sbjct: 297 QQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQ 356
Query: 332 IQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQS-QCQISTLRAQLQ 389
+Q + + ++++L E E+++ Q E Q +Q L+ + A Q Q +++ ++ +LQ
Sbjct: 357 LQ-LKLQEELQQL--EQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQ 412
Score = 38.5 bits (88), Expect = 0.024
Identities = 56/256 (21%), Positives = 120/256 (46%), Gaps = 34/256 (13%)
Query: 87 LRLAQLIIEYLLHCQDCLSASVA--QLEARLQTSLGQQQRGQQELGRQADELKGVREESR 144
L+ Q + +L Q+ L V QL + Q L QQQ QQ+ Q + + +E+ +
Sbjct: 177 LQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQ 236
Query: 145 RRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQP 204
++++++ QQ +Q + +Q++ A + + +++Q Q
Sbjct: 237 QQQQLLLLQQQGQLQ----------------------QQLLQQQQAQLQQQLLEQQQAQL 274
Query: 205 VEEVLEELRAKLKWTQGE--LEAQREAERQRQLQEAELIHQREIEAKKEF---DKWKEQE 259
+++L + + +L+ Q + L+ Q+E +Q+QLQ L + E E + E D EQE
Sbjct: 275 QQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQE 334
Query: 260 WTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQ 319
+ E+++ ++L + + + L+E+L+ L+ +E + L +E + L
Sbjct: 335 LEQQRQELERQQEL--ERQQEQRQLQLKLQEELQQLEQQ--LEQQQQQLEQQEVQLELTP 390
Query: 320 ARELQALREKTEIQKT 335
EL A +++ +++ T
Sbjct: 391 V-ELGAQQQEVQLELT 405
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 71.6 bits (174), Expect = 3e-12
Identities = 98/441 (22%), Positives = 200/441 (45%), Gaps = 52/441 (11%)
Query: 113 ARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCD 172
A+LQ L + + E+ ELK E R K++ QQL + HL
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKLE----RAKLLLPQQQLQAEAD-------HLGK 272
Query: 173 KTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQ 232
+ + L+ ++ +Q+++ EE ++E K+ Q + E RE E +
Sbjct: 273 ELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKI---QEQEEKIREQEEK 329
Query: 233 RQLQEAELIHQREIEAKKEFDKWKEQE---WTKLYGEIDKLKKLFWDEFKNVAKQNSTL- 288
+ QE ++ Q E+ +KE +K + QE W K ++ + +++ W++ + + +Q +
Sbjct: 330 IREQEEKMRRQEEMMWEKE-EKMRRQEEMMWEK-EEKMRRQEEMMWEKEEKMRRQEEMMW 387
Query: 289 --EEKLRALQSHSVMESKLGSLRDEESEE------WLRQARELQALREKTEIQKTEWKRK 340
EEK+R L+ + K+ ++ EE RQ +E + R++ +I++ E K +
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 447
Query: 341 VKE----LHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIA 396
+E EE + E+++++EE +R Q +++ Q +I + ++ EQ I
Sbjct: 448 EQEKKMWRQEEKIHEQEKIREEEKR-QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR 506
Query: 397 SQEEMIQSLSLRKVEGIHKVPKAVDTEEDS---------PEEEM---EDSQDEQHKVLAA 444
QEE + R+ E I + + + +E+ +EEM E+ EQ K+
Sbjct: 507 KQEEKV----WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE 562
Query: 445 LRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSE 504
+R K +R E+ + E+ E + R++ K + R + ++E+K R+ E
Sbjct: 563 EKRQEQEDKMWRQ--EEKIREQEEKVW-RQEEKIREQEEKRQEQEEKMWKQEEKIREQEE 619
Query: 505 FLSLRGKLVKEVTSRAKERQE 525
+ + + ++E + +E++E
Sbjct: 620 KIQEQEEKIREQEEKIREQEE 640
Score = 68.6 bits (166), Expect = 2e-11
Identities = 63/248 (25%), Positives = 119/248 (47%), Gaps = 17/248 (6%)
Query: 200 KQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQE 259
+QE+ + E E R K K + E E R+ E + QE ++ Q E ++E W+++E
Sbjct: 480 RQEEKIHEQEEIWRQKEKMHEQE-EKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE 538
Query: 260 WTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQ 319
+ E+ W E + + +Q EE+ R Q + + +R++E + W RQ
Sbjct: 539 KIREQEEM-------WREEEKMHEQEKIWEEEKRQEQEDKMWRQE-EKIREQEEKVW-RQ 589
Query: 320 ARELQALREKTEIQKTE-WKR--KVKELHE--EHMAEKKELQEENQRLQASLSQDQKKAA 374
+++ EK + Q+ + WK+ K++E E + EK QEE R Q ++Q+Q++
Sbjct: 590 EEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKM 649
Query: 375 AQSQCQISTLRAQLQEQARIIASQEEMI--QSLSLRKVEGIHKVPKAVDTEEDSPEEEME 432
+ + ++ ++QEQ + QEE I Q +R+ E + + + E++ E E
Sbjct: 650 GEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 709
Query: 433 DSQDEQHK 440
+ EQ +
Sbjct: 710 EKMCEQEE 717
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/297 (19%), Positives = 137/297 (46%), Gaps = 28/297 (9%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
++++ Q+E+ RQ +++ E R++ KM +++ Q +K +
Sbjct: 470 EKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQE-----------EKVWRQEEK 518
Query: 181 LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGEL---EAQREAERQRQLQE 237
+R ++ + K +QE+ + E E R + K + E E +R+ + + ++
Sbjct: 519 IREQEEKIRE---QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575
Query: 238 AELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQS 297
E I ++E + ++ +K +EQE + + ++ W + + + +Q ++E+ ++
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKR-----QEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 298 HSVMESKLGSLRDEESEEWLRQARELQALREKTEIQK-TEWKRKVKELHEEHMAEKKELQ 356
+ + E+ E+ Q ++ EK + Q+ T W+++ K +E +K Q
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE---KKIREQ 687
Query: 357 EENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMI--QSLSLRKVE 411
EE R Q + Q+Q++ + + ++ ++QEQ + QEE + Q + LR+ E
Sbjct: 688 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQE 744
Score = 51.2 bits (121), Expect = 4e-06
Identities = 75/350 (21%), Positives = 154/350 (44%), Gaps = 39/350 (11%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWK 256
+QK Q E + EL A++ T L Q+ + + Q E EA+ +
Sbjct: 110 EQKASHQHQEALRRELEAQVH-TIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 257 EQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEW 316
+ W K GE+++ + K + L ++ AL +E ++ DEE +E
Sbjct: 169 DS-W-KFAGELEQALSAVATQKKKADRYIEELTKERDALS----LELYRNTITDEELKE- 221
Query: 317 LRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQ 376
+ +LQ + E +K+E + VKEL + E+ +L Q+LQA K+ +
Sbjct: 222 --KNAKLQEKLQLVESEKSEIQLNVKEL--KRKLERAKLLLPQQQLQAEADHLGKELQSV 277
Query: 377 SQCQISTLRAQLQEQA---RIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMED 433
S + L+AQ++E R+ QEE + R+ E I + + + +E+ E+ E
Sbjct: 278 S----AKLQAQVEENELWNRLNQQQEEKM----WRQEEKIQEWEEKIQEQEEKIREQEEK 329
Query: 434 SQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRV 493
++++ K +RR E+ + EK E M +++ + +R E ++
Sbjct: 330 IREQEEK----MRRQ-----------EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM-W 373
Query: 494 QREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQ 543
++E+K R+ E + + + ++E+ + E+++ + + ++ Q+
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 70.5 bits (171), Expect = 6e-12
Identities = 70/329 (21%), Positives = 143/329 (43%), Gaps = 34/329 (10%)
Query: 118 SLGQQQRGQQELGRQADELKGVR----EESRRRRKMISTLQQLLMQTGTHSYHTCHLCDK 173
S +++R + E R+ +E + +R EE +RRR L+++ ++ ++
Sbjct: 533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQARER 587
Query: 174 TFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQR 233
+ I+++ A + E ++ K+E+ EE ++ A K + E ++E E +R
Sbjct: 588 VEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR 647
Query: 234 ----QLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLE 289
Q +E E HQ ++ KKE +EQE + E +L + E + ++
Sbjct: 648 LRWLQQEEEERRHQELLQKKKE----EEQERLRKAAEAKRLAEQREQERREQERREQERR 703
Query: 290 EKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHM 349
E+ R Q E +L +E L+ RELQ + +QK + +R+++
Sbjct: 704 EQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE------- 756
Query: 350 AEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRK 409
EKK+ +E+ + + L ++Q+K A ++ L + Q+ S + Q
Sbjct: 757 -EKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG----- 810
Query: 410 VEGIHKVPKAVDTEEDSPEEEMEDSQDEQ 438
H+ P ++ + + +DS D++
Sbjct: 811 ----HRAPPKINPDNYGMDLNSDDSTDDE 835
Score = 57.8 bits (138), Expect = 4e-08
Identities = 70/303 (23%), Positives = 123/303 (40%), Gaps = 30/303 (9%)
Query: 284 QNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE 343
+N +E+ L+ V E K L + + + R + LQA RE+ E K E K+++
Sbjct: 543 ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA-RERVEQMKEEKKKQI-- 599
Query: 344 LHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEE--- 400
E+ A+ E E+ + + + + +KKAAA+ ++ R Q +E R+ Q+E
Sbjct: 600 --EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 657
Query: 401 -----MIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHF 455
++Q + E + K +A E +E E + EQ + RR +
Sbjct: 658 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-REQERREQERREQE 716
Query: 456 RPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKE 515
R + E + E + ++ L+ E LR+Q+EQ R+ E K KE
Sbjct: 717 RQLAEQERRREQERLQAERE--------LQEREKALRLQKEQLQRELEE------KKKKE 762
Query: 516 VTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVALPSTPAEPPPPTRQ 575
R ERQ + + + + ++ VT + Q T P PP
Sbjct: 763 EQQRLAERQLQ--EEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPD 820
Query: 576 SHG 578
++G
Sbjct: 821 NYG 823
Score = 30.4 bits (67), Expect = 6.5
Identities = 45/174 (25%), Positives = 67/174 (38%), Gaps = 32/174 (18%)
Query: 499 ARKFSEFLSLRGKLVKEVTSR-AKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRT 557
A+K+S ++ + +V+ + R AK+ E AA G+ S L+ E K +
Sbjct: 319 AQKYS-LVAKQESVVRRASRRLAKKTAEEPAA----SGRIICHSYLERLLNVEVPQKVGS 373
Query: 558 LQV-----ALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPSSTPPSSG----- 607
Q A P AEP P + S + T+++ P+P S PS+G
Sbjct: 374 EQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAK 433
Query: 608 ----PGMSTPPFSS----------EEDSEGDRVQRVSLQPP--KVPSRMVPRPK 645
G PP S+ E E ++ LQPP K PS P K
Sbjct: 434 TDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
>gi|92091575 coiled-coil domain containing 57 [Homo sapiens]
Length = 915
Score = 70.5 bits (171), Expect = 6e-12
Identities = 109/485 (22%), Positives = 200/485 (41%), Gaps = 55/485 (11%)
Query: 195 GGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDK 254
G K + Q E EL KL+ GEL+ R R + +H ++ KKE
Sbjct: 221 GAKAAESLQRAEATNAELERKLQSRAGELQDLEAMSRARVKDLEDKLHSVQLTRKKE--- 277
Query: 255 WKEQEWTKLYGEIDKL---KKLFWDEFKNV-AKQNSTLEEKLRALQSH-SVMESKLGSLR 309
E+ + + + E+D+L K K +Q L+ ++ LQ+H +E++L
Sbjct: 278 --EETFKRKHEELDRLAREKDAVLVAVKGAHVEQLQELQTRVLELQAHCETLEAQLRRAE 335
Query: 310 DEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMA---EKKELQEENQRLQASL 366
+++ + + LRE K+ W ++ +L +E ++ + + LQEE +L+A +
Sbjct: 336 WRQADTAKEKDAAIDQLREDASTVKSAWDAQIAQLSKEMVSRDLQIQTLQEEEVKLKAQV 395
Query: 367 S---QDQKKAAAQSQCQISTLRAQLQEQARI---------------IASQEEMIQSLSLR 408
+ QD ++ Q + R+ ++Q ++ I E +IQ LS+
Sbjct: 396 ARSQQDIERYKQQLSLAVERERSLERDQVQLGLDWQRRCDDIERDQIQKSEALIQGLSMA 455
Query: 409 KVEGIHKVPKAVDTEEDSPEEE--MEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEK 466
K + K +TE+ E+E ++ E+ + + ALR + + +L EE
Sbjct: 456 KSQ---VAAKLQETEQALQEQEVVLKAVTLERDQAVQALRMHGLPRPGAQMLLRQHEEE- 511
Query: 467 LESMGIRKDAKGISIQTLRHLESLLR---VQREQKARKFSEFLSLRGKLVKEVTSRAKER 523
I KD IQ LR + LR Q ++ S + + E T +
Sbjct: 512 -----ISKDFPSSEIQRLREQNTSLRNAIAQMRKEMEALSHQIPPPIQTAAESTDANQPD 566
Query: 524 QENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVALPST--PAEPPPPTRQSHGSHG 581
E G + PD +++++ R + K +TL+ L P + P +S S
Sbjct: 567 PEAGGDAATPDYVLALEAE-----IRTLKHKFKTLEKHLEDVLDPLKMSSPHAESQPSVR 621
Query: 582 SSLTQVSAPAPHPGLHGPSSTPPSSGPGMSTPPFSS--EEDSEGDRVQRVSLQPPKVPSR 639
+S T+ + + G G S +G + P SS GDRVQ ++L ++ +
Sbjct: 622 TS-TETTGGSAQAGQAGGSVQAGQAGGSVQAGPVSSGLALRKLGDRVQLLNLLVTRLRQK 680
Query: 640 MVPRP 644
++ P
Sbjct: 681 VLREP 685
Score = 50.4 bits (119), Expect = 6e-06
Identities = 84/384 (21%), Positives = 161/384 (41%), Gaps = 48/384 (12%)
Query: 198 QKKQEQPVEEVLEELRAKLKWTQGELEAQRE--AERQRQLQEAELIHQREIEAKKEFDKW 255
Q + Q E L++ R++L+ QG+L +E + L+E +L +R A + +W
Sbjct: 25 QAHRTQLQEAALQDTRSQLEEAQGKLRCLQEDFVYNLQVLEERDLELERYDAAFAQAREW 84
Query: 256 KEQ---EWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEE 312
+E E ++L E KL++ E + V + +++ A Q H + ++ S ++ E
Sbjct: 85 EEARRAEVSELKIEAAKLRQALAREARKVEELQ---QQQQLAFQEHRLELERVHSDKNGE 141
Query: 313 SEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKEL----------QEENQRL 362
+ RE+ E K +RK++EL E +++EL +E RL
Sbjct: 142 IDHH----------REQYENLKWTLERKLEELDGELALQRQELLLEFESKMRKREHEFRL 191
Query: 363 QASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDT 422
QA + A + ++ L +L+ A E +Q E K+
Sbjct: 192 QA---DNMSNTALSRELKVKLLHKELEALKEAGAKAAESLQRAEATNAELERKLQSRAGE 248
Query: 423 EED---SPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGI 479
+D ++D +D+ H V ++ K E+L+ + KDA +
Sbjct: 249 LQDLEAMSRARVKDLEDKLHSVQLTRKKEEETFKR--------KHEELDRLAREKDAVLV 300
Query: 480 SIQTLRHLESLLRVQ-REQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQ-PDGQP 537
+++ H+E L +Q R + + E +L +L + +A +E AA+ Q +
Sbjct: 301 AVKG-AHVEQLQELQTRVLELQAHCE--TLEAQLRRAEWRQADTAKEKDAAIDQLREDAS 357
Query: 538 SVKSQQSALVTR-EAQPKTRTLQV 560
+VKS A + + + +R LQ+
Sbjct: 358 TVKSAWDAQIAQLSKEMVSRDLQI 381
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 70.1 bits (170), Expect = 7e-12
Identities = 69/326 (21%), Positives = 142/326 (43%), Gaps = 34/326 (10%)
Query: 121 QQQRGQQELGRQADELKGVR----EESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFM 176
+++R + E R+ +E + +R EE +RRR L+++ ++ ++
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQARERVEQ 586
Query: 177 NATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQR--- 233
+ I+++ A + E ++ K+E+ EE ++ A K + E ++E E +R
Sbjct: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
Query: 234 -QLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKL 292
Q +E E HQ ++ KKE +EQE + E +L + E + ++ E+
Sbjct: 647 LQQEEEERRHQELLQKKKE----EEQERLRKAAEAKRLAEQREQERREQERREQERREQE 702
Query: 293 RALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEK 352
R Q E +L +E L+ RELQ + +QK + +R+++ EK
Sbjct: 703 RREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELE--------EK 754
Query: 353 KELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEG 412
K+ +E+ + + L ++Q+K A ++ L + Q+ S + Q
Sbjct: 755 KKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQG-------- 806
Query: 413 IHKVPKAVDTEEDSPEEEMEDSQDEQ 438
H+ P ++ + + +DS D++
Sbjct: 807 -HRAPPKINPDNYGMDLNSDDSTDDE 831
Score = 57.8 bits (138), Expect = 4e-08
Identities = 70/303 (23%), Positives = 123/303 (40%), Gaps = 30/303 (9%)
Query: 284 QNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE 343
+N +E+ L+ V E K L + + + R + LQA RE+ E K E K+++
Sbjct: 539 ENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQA-RERVEQMKEEKKKQI-- 595
Query: 344 LHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEE--- 400
E+ A+ E E+ + + + + +KKAAA+ ++ R Q +E R+ Q+E
Sbjct: 596 --EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEE 653
Query: 401 -----MIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHF 455
++Q + E + K +A E +E E + EQ + RR +
Sbjct: 654 RRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQER-REQERREQERREQE 712
Query: 456 RPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKE 515
R + E + E + ++ L+ E LR+Q+EQ R+ E K KE
Sbjct: 713 RQLAEQERRREQERLQAERE--------LQEREKALRLQKEQLQRELEE------KKKKE 758
Query: 516 VTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVALPSTPAEPPPPTRQ 575
R ERQ + + + + ++ VT + Q T P PP
Sbjct: 759 EQQRLAERQLQ--EEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPD 816
Query: 576 SHG 578
++G
Sbjct: 817 NYG 819
Score = 31.6 bits (70), Expect = 2.9
Identities = 42/229 (18%), Positives = 92/229 (40%), Gaps = 34/229 (14%)
Query: 333 QKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQA 392
+K +K+ V EL EE E +ELQ + +S C S + L+
Sbjct: 449 RKRSYKQAVSELDEEQHLEDEELQPPRSKTPSS------------PCPASKVVRPLRTFL 496
Query: 393 RIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEME-DSQDEQHKVLAALRRNPTL 451
+ + ++ S P++V + D ++++ + L LRR
Sbjct: 497 HTVQRNQMLMTPTS---------APRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEA 547
Query: 452 LKHFRPILEDTLEEKLESMGIRKDAKGISI-QTLRHLESLLRVQREQKARKFSEFLSLRG 510
+ R +E+ +LE + ++++ + + Q +E + +++Q +KF++
Sbjct: 548 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ------ 601
Query: 511 KLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
+ E T +AKE + A + + + K + R+ + + R L+
Sbjct: 602 --IDEKTEKAKEER---LAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 645
Score = 30.4 bits (67), Expect = 6.5
Identities = 45/174 (25%), Positives = 67/174 (38%), Gaps = 32/174 (18%)
Query: 499 ARKFSEFLSLRGKLVKEVTSR-AKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRT 557
A+K+S ++ + +V+ + R AK+ E AA G+ S L+ E K +
Sbjct: 319 AQKYS-LVAKQESVVRRASRRLAKKTAEEPAA----SGRIICHSYLERLLNVEVPQKVGS 373
Query: 558 LQV-----ALPSTPAEPPPPTRQSHGSHGSSLTQVSAPAPHPGLHGPSSTPPSSG----- 607
Q A P AEP P + S + T+++ P+P S PS+G
Sbjct: 374 EQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAK 433
Query: 608 ----PGMSTPPFSS----------EEDSEGDRVQRVSLQPP--KVPSRMVPRPK 645
G PP S+ E E ++ LQPP K PS P K
Sbjct: 434 TDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASK 487
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 69.7 bits (169), Expect = 1e-11
Identities = 74/333 (22%), Positives = 159/333 (47%), Gaps = 36/333 (10%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWK 256
K ++ E+ + E E++R +L+ E E RE E +RQ E E I ++E ++E W+
Sbjct: 364 KMRRLEEMMWEKEEKIR-ELEEKMHEQEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWR 420
Query: 257 EQEWTKLYGE-IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEE 315
++E + E I + +K W + + + +Q EE+ R Q M + +R++E E
Sbjct: 421 QEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR--QEQEEMWRQEEKIREQE-EI 477
Query: 316 WLRQARELQALREKTEIQKTEWK--RKVKELHEEHMAEKKELQEENQRLQASLSQDQKKA 373
W R+ + + E+ +I+K E K R+ +++H++ EK QEE Q ++Q++
Sbjct: 478 W----RQKEKMHEQEKIRKQEEKVWRQEEKMHDQE--EKIREQEEKMWRQEEKIREQEEK 531
Query: 374 AAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMED 433
+ + +I +QEQ + QEE +Q + E + + + + +E+ E+ E
Sbjct: 532 IREQEEKIREQEEMMQEQEEKMGEQEEKMQ-----EQEKMRRQEEKIREQEEKIREQKEK 586
Query: 434 SQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRV 493
++++ K+ E+ + E+ E M +++ + + E ++
Sbjct: 587 IREQEEKIWEQ---------------EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ- 630
Query: 494 QREQKARKFSEFLSLRGKLVKEVTSRAKERQEN 526
++E+K R+ E + + +++ + +E QE+
Sbjct: 631 EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 663
Score = 63.5 bits (153), Expect = 7e-10
Identities = 69/362 (19%), Positives = 162/362 (44%), Gaps = 35/362 (9%)
Query: 108 VAQLEARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLL--MQTGTHSY 165
+ + E +++ ++++ RQ + + E+ RR +M+ ++ + ++ H
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 166 HTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLK--WTQGE- 222
++ +R +R+ + K +QE+ + E E++R + K W Q E
Sbjct: 390 EKIREQEEKRQEEEKIREQEKRQE----QEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445
Query: 223 LEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVA 282
+ Q + + + QE E + ++E + +++ + W+++E +I K ++ W + + +
Sbjct: 446 IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMH 505
Query: 283 KQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQ--KTEWKRK 340
Q EEK+R E+ E+ RQ +++ EK Q K + +
Sbjct: 506 DQ----EEKIR-----------------EQEEKMWRQEEKIREQEEKIREQEEKIREQEE 544
Query: 341 VKELHEEHMAEKKELQEENQRL--QASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQ 398
+ + EE M E++E +E +++ Q ++Q++ + + +I ++ EQ I Q
Sbjct: 545 MMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQ 604
Query: 399 EEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPI 458
EEM+Q + E K+ + + ++ EE+M +++ + LR+ ++ +
Sbjct: 605 EEMMQEQEEKMWEQEEKMCEQEEKMQEQ-EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 663
Query: 459 LE 460
LE
Sbjct: 664 LE 665
Score = 57.8 bits (138), Expect = 4e-08
Identities = 80/379 (21%), Positives = 171/379 (45%), Gaps = 42/379 (11%)
Query: 183 GHIQRRHAGVAEGGKQKKQEQPVEEVLEELRA-KLKWTQGELEAQREAERQRQLQEA-EL 240
G +++ + VA ++KK ++ +EE+ +E A L+ + + + E+ +LQE +L
Sbjct: 175 GELEQALSAVAT--QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL 232
Query: 241 IHQREIEAKKEFDKWKEQ-EWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHS 299
+ + E + + K + E KL +L+ E ++ K+ ++ KL+A
Sbjct: 233 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQA----EADHLGKELQSVSAKLQA----- 283
Query: 300 VMESKLGSLRDEESEEW--LRQARELQALREKTEIQKTEWKRKVKELHEE--HMAEKKEL 355
+ EE+E W L Q +E + R++ +IQ EW+ K++E E+ EK
Sbjct: 284 ---------QVEENELWNRLNQQQEEKMWRQEEKIQ--EWEEKIQEQEEKIREQEEKIRE 332
Query: 356 QEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHK 415
QEE R Q + ++++ + + + +++ ++ +EE I+ L E +H+
Sbjct: 333 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELE----EKMHE 388
Query: 416 VPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKD 475
K + EE EEE Q+++ + A + R ++ E+ + E+ + M R++
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE----QEEKIREQEKKMW-RQE 443
Query: 476 AKGISIQTLRHLESLLRVQ----REQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVS 531
K + +R E + +E+K R+ E + K+ ++ R +E +
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEK 503
Query: 532 QPDGQPSVKSQQSALVTRE 550
D + ++ Q+ + +E
Sbjct: 504 MHDQEEKIREQEEKMWRQE 522
Score = 55.1 bits (131), Expect = 2e-07
Identities = 66/319 (20%), Positives = 144/319 (45%), Gaps = 47/319 (14%)
Query: 114 RLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDK 173
RL+ + +++ +EL + E + +RE+ +R++ +Q Q
Sbjct: 367 RLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE------------- 413
Query: 174 TFMNATFLRGH--IQRRHAGVAEGGKQK-KQEQPVEEVLEELRAKLKWTQGELEAQREAE 230
A R I+ + + E K+ +QE+ + E E++R + K + E E R+ E
Sbjct: 414 --QEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQ-EKIREEEKRQEQE-EMWRQEE 469
Query: 231 RQRQLQEA----ELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKL---FWDEFKNVAK 283
+ R+ +E E +H++E K+E W+++E K++ + +K+++ W + + + +
Sbjct: 470 KIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEE--KMHDQEEKIREQEEKMWRQEEKIRE 527
Query: 284 QNSTLEEKLRALQSHSVM----ESKLGSLRD--EESEEWLRQARELQALREKTEIQKTE- 336
Q + E+ ++ M E K+G + +E E+ RQ +++ EK QK +
Sbjct: 528 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI 587
Query: 337 -------WKRKVKELHEEHMA----EKKELQEENQRLQASLSQDQKKAAAQSQCQISTLR 385
W+++ K +E M EK QEE Q Q+Q++ + + ++
Sbjct: 588 REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647
Query: 386 AQLQEQARIIASQEEMIQS 404
+L++Q + +E +++
Sbjct: 648 VRLRQQEEKMQEHQEHLEA 666
>gi|156104874 envoplakin [Homo sapiens]
Length = 2033
Score = 69.3 bits (168), Expect = 1e-11
Identities = 111/530 (20%), Positives = 219/530 (41%), Gaps = 86/530 (16%)
Query: 110 QLEARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCH 169
Q +RL++ L +++ L R+ +L ++R + +++ +
Sbjct: 1150 QESSRLRSLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERV--------HEIFQ 1201
Query: 170 LCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREA 229
+ +T T L+ +Q GK+ E+ VE++L +L L AQ+
Sbjct: 1202 VDPETEQEITRLKAKLQEM------AGKRSGVEKEVEKLLPDLEV--------LRAQKPT 1247
Query: 230 ERQRQLQEAELIHQREIEAKKEFDKWKEQ-------------EWTKLYGEIDKLKKLFWD 276
+++ + + H+R E +E D+ K Q + +L GE D+ ++
Sbjct: 1248 VEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRR---- 1303
Query: 277 EFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDE--ESEEWLRQAR----ELQALREKT 330
+ + T+ +++ + V+E + LR E E+ + R A ELQ+ R
Sbjct: 1304 --ERAKVETKTVSKEVVRHEKDPVLEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLL 1361
Query: 331 EIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQE 390
E +K E K V+E+ K L+EE+ RL SL ++ + Q + ++ LRA ++E
Sbjct: 1362 ERRKPEEKVVVQEVVVTQKDPK--LREEHSRLSGSLDEEVGRRR-QLELEVQQLRAGVEE 1418
Query: 391 QARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPT 450
Q +++ QE+ + L++ + + ++ + E P E E+ + L ++P
Sbjct: 1419 QEGLLSFQEDRSKKLAVER--ELRQLTLRIQELEKRPPTVQEKIIMEE---VVKLEKDPD 1473
Query: 451 LLKHFRPILEDTLEEKLESMGIRKDAKGISIQ--TLRHLES--------LLRVQ------ 494
L K + D +EK + + ++ K + +Q L+ +S ++RVQ
Sbjct: 1474 LEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLE 1533
Query: 495 -----------REQKAR--KFSEFLSLRGKLVK-EVTSRAKERQENGAAVSQPDGQPSVK 540
RE+ AR + E LR ++ + E R R+E+ ++
Sbjct: 1534 DERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECG 1593
Query: 541 SQQSALVTREAQPKTRTLQVALPS-TPAEPPPPTRQSHGSHGSSLTQVSA 589
Q L E Q + +TLQ+ S ++ RQ G L+++ A
Sbjct: 1594 RLQQELRALERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEA 1643
Score = 51.2 bits (121), Expect = 4e-06
Identities = 63/275 (22%), Positives = 125/275 (45%), Gaps = 35/275 (12%)
Query: 185 IQRRHAGVAEGG------KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQE- 237
+Q+ AGV E + + ++ VE L +L +++ ELE + +++ + E
Sbjct: 1409 VQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQ----ELEKRPPTVQEKIIMEE 1464
Query: 238 -AELIHQREIEAKKEFDKW----KEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKL 292
+L ++E E +W ++ + T+L E L+ D + Q T+ +++
Sbjct: 1465 VVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQI-DVLQKAKSQEKTIYKEV 1523
Query: 293 RALQSHSVMESKLGSLRDE-ESEEWLRQARELQALREKTEIQKTE-----WKRKVKELHE 346
+Q V+E + + + E RQARE +A R + I + E W R+ EL
Sbjct: 1524 IRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRTWSREESELQR 1583
Query: 347 EHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLS 406
+ + +E RLQ Q+ A + Q Q TL QLQE++++++ + E + +
Sbjct: 1584 A----RDQADQECGRLQ------QELRALERQKQQQTL--QLQEESKLLSQKTESERQKA 1631
Query: 407 LRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKV 441
++ + + ++ A+ E+D E+ +D KV
Sbjct: 1632 AQRGQELSRLEAAILREKDQIYEKERTLRDLHAKV 1666
Score = 48.5 bits (114), Expect = 2e-05
Identities = 111/564 (19%), Positives = 226/564 (40%), Gaps = 88/564 (15%)
Query: 82 ALLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVRE 141
A +V Q +++ L + L + R Q + GR+++ LK E
Sbjct: 863 AYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLE 922
Query: 142 ESRRRRKMI--------STLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVA 193
E R+R + S L QL Q + + F L G + R A V
Sbjct: 923 EERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVE--FYRDPQLEGSLSRVKAQVE 980
Query: 194 EGGK---------------------QKKQEQP---VEEVLE------------ELRAKLK 217
E GK ++K QP +EV + +LR +++
Sbjct: 981 EEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQ 1040
Query: 218 WTQGE----------LEAQREAERQRQLQEAELIHQRE-IEAKKEFDKWKEQEWTKLYGE 266
+GE L+ + A +R++ E + +E ++ +K + K + +L E
Sbjct: 1041 QLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQME 1100
Query: 267 IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQAL 326
D ++ +E VAK + +E+ RA+ S + E+ L+++ L++L
Sbjct: 1101 EDAARRKQAEE--AVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSL 1158
Query: 327 REKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRA 386
E+ + R++ +LH ++ +K Q +LQ + + + +++ +I+ L+A
Sbjct: 1159 LEEERTKNATLARELSDLHSKYSVVEK--QRPKVQLQERV-HEIFQVDPETEQEITRLKA 1215
Query: 387 QLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALR 446
+LQE A + E+ ++ L L +E + V+ +E + E + E + + L+
Sbjct: 1216 KLQEMAGKRSGVEKEVEKL-LPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLK 1274
Query: 447 R--NPTLLKHFRPILEDTLEEKLESMGIRKD--AKGISIQTLRHLESLLRVQREQKARKF 502
N + H R + E+ + G R + + ++T + ++R +++ K
Sbjct: 1275 AQLNELVNSHGR-----SQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKE 1329
Query: 503 SEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVAL 562
+E +L +EV A++R+ AV + ++S++ L R+ + K +V +
Sbjct: 1330 AE------RLRQEVREAAQKRRAAEDAVYE------LQSKRLLLERRKPEEKVVVQEVVV 1377
Query: 563 PSTPAEPPPPTRQSHGSHGSSLTQ 586
+ P R+ H SL +
Sbjct: 1378 ----TQKDPKLREEHSRLSGSLDE 1397
Score = 33.5 bits (75), Expect = 0.76
Identities = 36/171 (21%), Positives = 73/171 (42%), Gaps = 19/171 (11%)
Query: 319 QARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQ 378
QA+E + TE+ + + + M EKKEL E+ +R ++ ++ AQ+
Sbjct: 854 QAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHD--AKQGSESPAQAG 911
Query: 379 CQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQ 438
+ L+AQL+E+ + +A + +++ + + + P E +E+
Sbjct: 912 RESEALKAQLEEERKRVARVQHELEA----------QRSQLLQLRTQRPLERLEE----- 956
Query: 439 HKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLES 489
K + R+P L + EE G++ D + ++ Q + LES
Sbjct: 957 -KEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGLQADLE-VAAQKVVQLES 1005
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 68.9 bits (167), Expect = 2e-11
Identities = 99/495 (20%), Positives = 208/495 (42%), Gaps = 71/495 (14%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
Q R ++E+ + DEL+ +E ++ + L+Q Q +L + T
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK----NLLQEQLQAETE 901
Query: 181 LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQG---ELEAQREAERQR---- 233
L + +A KKQE +EE+L E+ A+L+ + +L+A+R+ Q+
Sbjct: 902 LYAEAEEMRVRLA----AKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 234 --QLQEAELIHQR----EIEAKKEFDKWKEQ------EWTKLYGEIDKLKKLFWDEFKNV 281
QL+E E Q+ ++ A+ + K +++ + KL E L++ D N+
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 282 AKQNSTLEEKLRALQSHSVMESKLG-SLRDEESEEWLRQARELQALREKTEIQKTEWKRK 340
A++ + + H M S+L L+ EE + +EL+ L+ K E +++ +
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEE-----KSRQELEKLKRKLEGDASDFHEQ 1070
Query: 341 VKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQC---------QISTLRAQL--- 388
+ +L + K +L ++ + LQA+L++ + A ++ IS L+ L
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 389 -------QEQARIIASQEEMI--------------QSLSLRKVEGIHKVPKAVDTEEDSP 427
++Q R + + E + Q L ++ + + + KA+D E S
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 428 EEEMEDSQDEQHKVLAALRRNPTLLKHFRPILE---DTLEEKLESMGIRKDAKGISIQTL 484
E ++++ + + + + L K + L+ TLE++ + G + Q +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 485 RHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
H + L Q ++ K S+ R +L +V E + +++ +G+ ++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 545 ALVTREAQPKTRTLQ 559
A ++ + Q LQ
Sbjct: 1311 ASLSSQLQDTQELLQ 1325
Score = 60.1 bits (144), Expect = 8e-09
Identities = 96/475 (20%), Positives = 192/475 (40%), Gaps = 45/475 (9%)
Query: 83 LLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREE 142
L+ L Q + LL + +S+ A R + +++ L R +E +EE
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 143 SRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQE 202
R KM+ + L+ + H +K + L ++ + E + +
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEE---LEDEL 1555
Query: 203 QPVEEVLEELRAKLKWTQGELEAQREA------ERQRQLQEAELIHQREIEAKKEFDKWK 256
Q E+ L ++ +G+ E +A E++RQLQ ++ E+E +++
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 257 EQEWTKLYGEIDKLK-------KLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLR 309
KL G++ L+ K + K + K + +++ R L+ ++ +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 310 DEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE--------KKELQEENQR 361
E ++ +L L+E ++ E RK +L +E +AE + LQ+E +R
Sbjct: 1676 KENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 362 LQASLSQ-DQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
L+A ++Q +++ Q + + R + Q S E + + +K E + +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 421 DTEEDSPEEEMEDSQDEQHK-VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDA--K 477
+ E S EME + + K +AAL LEE++E K A K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQVEQEAREKQAATK 1842
Query: 478 GISIQTLRHLESLLRVQREQK-ARKFSEFLSLRGKLVKEVTSRAKERQENGAAVS 531
+ + + E LL+V+ E+K A ++ E VK++ + +E +E ++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Score = 58.2 bits (139), Expect = 3e-08
Identities = 85/383 (22%), Positives = 167/383 (43%), Gaps = 45/383 (11%)
Query: 201 QEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEW 260
+E+ ++ + + A +G L + A+RQ+QL ++I QR A + W +W
Sbjct: 779 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVI-QRNCAAYLKLRNW---QW 834
Query: 261 TKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQA 320
+L+ ++ L ++ E + AK++ + K R ++ E++L L + S+
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQ----LT 886
Query: 321 RELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQ 380
E L+E+ + + TE + +E+ A+K+EL+E ++A L +++ + Q Q +
Sbjct: 887 EEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAE 944
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
+ Q+ + + +E Q L L KV K+ K E+E+ D+ +K
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL--------EDEILVMDDQNNK 996
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKAR 500
L + LL+ L L E+ E K + LE +R+++E+K+R
Sbjct: 997 ----LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKEEKSR 1050
Query: 501 KFSEFL----------------SLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
+ E L L+ ++ + AK+ +E AA+++ D + + K+
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 545 ALVTREAQPKTRTLQVALPSTPA 567
+ RE + LQ L S A
Sbjct: 1111 KKI-RELEGHISDLQEDLDSERA 1132
Score = 58.2 bits (139), Expect = 3e-08
Identities = 106/502 (21%), Positives = 214/502 (42%), Gaps = 80/502 (15%)
Query: 108 VAQLEARLQTSLGQQQRGQQELGRQADELKG----VREESRRRRKMISTLQ-QLLMQTGT 162
+++LE RL+ ++++ +QEL + +L+G E+ + I+ L+ QL +
Sbjct: 1036 ISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 163 HSYHTCHLCDKTFMNATFLR------GHIQRRHAGV----AEGGKQKKQEQPVEEVLEEL 212
L D+ L+ GHI + A K +KQ++ + E LE L
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 213 RAKLK------WTQGELEAQREAE---RQRQLQEAELIHQREIEAKKEFDKWKEQEWTKL 263
+ +L+ TQ EL A+RE E ++ L E H+ +++ ++ +E T+
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 264 YGEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEESEEWLRQARE 322
+ + K + + K+N+ L +LR L Q+ +E K L Q +E
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--------AQVQE 1263
Query: 323 LQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQIS 382
LQ+ E + E KV +LQ E + + L++ + KA ++ ++
Sbjct: 1264 LQSKCSDGERARAELNDKV-----------HKLQNEVESVTGMLNEAEGKAIKLAK-DVA 1311
Query: 383 TLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQD-EQH-- 439
+L +QLQ+ ++ QEE Q L++ + ++ + ++ +D +EEME Q+ E+H
Sbjct: 1312 SLSSQLQDTQELL--QEETRQKLNVS--TKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 440 KVLAALRRNPTLLKHFRPILE------DTLEEKLESMGIRKDAKGISIQTLRHLESLLRV 493
+ L + L+ F +E ++++E++ + + K + L ++ L+
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 494 Q-----------------REQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQ 536
+ E+K RKF + L+ K + + ++R E A +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 537 PSVKSQQSALVTREAQPKTRTL 558
++ + AL +E +T +
Sbjct: 1487 SLARALEEALEAKEELERTNKM 1508
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/269 (19%), Positives = 117/269 (43%), Gaps = 21/269 (7%)
Query: 114 RLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDK 173
+LQ + QR ++ DE+ +E+ ++ K +L+ LMQ ++
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQL----QEDLAAAER 1701
Query: 174 TFMNATFLRGHIQRRHAGVAEGGKQKKQEQP-VEEVLEELRAKLKWTQGELEAQREAERQ 232
A + + A G + E+ +E + +L +L+ QG +EA + R+
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 233 RQLQEAELIH---------QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAK 283
Q +L + Q+ A+++ ++ ++ +KL+ +K F +
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 284 QNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE 343
+ + LEE++ +K +D++ +E L Q + + + E+ + Q + +VK+
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 344 LHEEHMAEKKELQEENQRLQASLSQDQKK 372
L + +E +EE+QR+ A+ + Q++
Sbjct: 1882 LKR----QLEEAEEESQRINANRRKLQRE 1906
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 68.9 bits (167), Expect = 2e-11
Identities = 99/495 (20%), Positives = 208/495 (42%), Gaps = 71/495 (14%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
Q R ++E+ + DEL+ +E ++ + L+Q Q +L + T
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK----NLLQEQLQAETE 908
Query: 181 LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQG---ELEAQREAERQR---- 233
L + +A KKQE +EE+L E+ A+L+ + +L+A+R+ Q+
Sbjct: 909 LYAEAEEMRVRLA----AKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 234 --QLQEAELIHQR----EIEAKKEFDKWKEQ------EWTKLYGEIDKLKKLFWDEFKNV 281
QL+E E Q+ ++ A+ + K +++ + KL E L++ D N+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 282 AKQNSTLEEKLRALQSHSVMESKLG-SLRDEESEEWLRQARELQALREKTEIQKTEWKRK 340
A++ + + H M S+L L+ EE + +EL+ L+ K E +++ +
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEE-----KSRQELEKLKRKLEGDASDFHEQ 1077
Query: 341 VKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQC---------QISTLRAQL--- 388
+ +L + K +L ++ + LQA+L++ + A ++ IS L+ L
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 389 -------QEQARIIASQEEMI--------------QSLSLRKVEGIHKVPKAVDTEEDSP 427
++Q R + + E + Q L ++ + + + KA+D E S
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 428 EEEMEDSQDEQHKVLAALRRNPTLLKHFRPILE---DTLEEKLESMGIRKDAKGISIQTL 484
E ++++ + + + + L K + L+ TLE++ + G + Q +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 485 RHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
H + L Q ++ K S+ R +L +V E + +++ +G+ ++
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 545 ALVTREAQPKTRTLQ 559
A ++ + Q LQ
Sbjct: 1318 ASLSSQLQDTQELLQ 1332
Score = 60.1 bits (144), Expect = 8e-09
Identities = 96/475 (20%), Positives = 192/475 (40%), Gaps = 45/475 (9%)
Query: 83 LLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREE 142
L+ L Q + LL + +S+ A R + +++ L R +E +EE
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 143 SRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQE 202
R KM+ + L+ + H +K + L ++ + E + +
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEE---LEDEL 1562
Query: 203 QPVEEVLEELRAKLKWTQGELEAQREA------ERQRQLQEAELIHQREIEAKKEFDKWK 256
Q E+ L ++ +G+ E +A E++RQLQ ++ E+E +++
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 257 EQEWTKLYGEIDKLK-------KLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLR 309
KL G++ L+ K + K + K + +++ R L+ ++ +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 310 DEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE--------KKELQEENQR 361
E ++ +L L+E ++ E RK +L +E +AE + LQ+E +R
Sbjct: 1683 KENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 362 LQASLSQ-DQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
L+A ++Q +++ Q + + R + Q S E + + +K E + +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 421 DTEEDSPEEEMEDSQDEQHK-VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDA--K 477
+ E S EME + + K +AAL LEE++E K A K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQVEQEAREKQAATK 1849
Query: 478 GISIQTLRHLESLLRVQREQK-ARKFSEFLSLRGKLVKEVTSRAKERQENGAAVS 531
+ + + E LL+V+ E+K A ++ E VK++ + +E +E ++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Score = 58.2 bits (139), Expect = 3e-08
Identities = 85/383 (22%), Positives = 167/383 (43%), Gaps = 45/383 (11%)
Query: 201 QEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEW 260
+E+ ++ + + A +G L + A+RQ+QL ++I QR A + W +W
Sbjct: 786 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVI-QRNCAAYLKLRNW---QW 841
Query: 261 TKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQA 320
+L+ ++ L ++ E + AK++ + K R ++ E++L L + S+
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQ----LT 893
Query: 321 RELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQ 380
E L+E+ + + TE + +E+ A+K+EL+E ++A L +++ + Q Q +
Sbjct: 894 EEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAE 951
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
+ Q+ + + +E Q L L KV K+ K E+E+ D+ +K
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL--------EDEILVMDDQNNK 1003
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKAR 500
L + LL+ L L E+ E K + LE +R+++E+K+R
Sbjct: 1004 ----LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKEEKSR 1057
Query: 501 KFSEFL----------------SLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
+ E L L+ ++ + AK+ +E AA+++ D + + K+
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 545 ALVTREAQPKTRTLQVALPSTPA 567
+ RE + LQ L S A
Sbjct: 1118 KKI-RELEGHISDLQEDLDSERA 1139
Score = 58.2 bits (139), Expect = 3e-08
Identities = 106/502 (21%), Positives = 214/502 (42%), Gaps = 80/502 (15%)
Query: 108 VAQLEARLQTSLGQQQRGQQELGRQADELKG----VREESRRRRKMISTLQ-QLLMQTGT 162
+++LE RL+ ++++ +QEL + +L+G E+ + I+ L+ QL +
Sbjct: 1043 ISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 163 HSYHTCHLCDKTFMNATFLR------GHIQRRHAGV----AEGGKQKKQEQPVEEVLEEL 212
L D+ L+ GHI + A K +KQ++ + E LE L
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 213 RAKLK------WTQGELEAQREAE---RQRQLQEAELIHQREIEAKKEFDKWKEQEWTKL 263
+ +L+ TQ EL A+RE E ++ L E H+ +++ ++ +E T+
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 264 YGEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEESEEWLRQARE 322
+ + K + + K+N+ L +LR L Q+ +E K L Q +E
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--------AQVQE 1270
Query: 323 LQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQIS 382
LQ+ E + E KV +LQ E + + L++ + KA ++ ++
Sbjct: 1271 LQSKCSDGERARAELNDKV-----------HKLQNEVESVTGMLNEAEGKAIKLAK-DVA 1318
Query: 383 TLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQD-EQH-- 439
+L +QLQ+ ++ QEE Q L++ + ++ + ++ +D +EEME Q+ E+H
Sbjct: 1319 SLSSQLQDTQELL--QEETRQKLNVS--TKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 440 KVLAALRRNPTLLKHFRPILE------DTLEEKLESMGIRKDAKGISIQTLRHLESLLRV 493
+ L + L+ F +E ++++E++ + + K + L ++ L+
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 494 Q-----------------REQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQ 536
+ E+K RKF + L+ K + + ++R E A +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 537 PSVKSQQSALVTREAQPKTRTL 558
++ + AL +E +T +
Sbjct: 1494 SLARALEEALEAKEELERTNKM 1515
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/269 (19%), Positives = 117/269 (43%), Gaps = 21/269 (7%)
Query: 114 RLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDK 173
+LQ + QR ++ DE+ +E+ ++ K +L+ LMQ ++
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQL----QEDLAAAER 1708
Query: 174 TFMNATFLRGHIQRRHAGVAEGGKQKKQEQP-VEEVLEELRAKLKWTQGELEAQREAERQ 232
A + + A G + E+ +E + +L +L+ QG +EA + R+
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 233 RQLQEAELIH---------QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAK 283
Q +L + Q+ A+++ ++ ++ +KL+ +K F +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 284 QNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE 343
+ + LEE++ +K +D++ +E L Q + + + E+ + Q + +VK+
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 344 LHEEHMAEKKELQEENQRLQASLSQDQKK 372
L + +E +EE+QR+ A+ + Q++
Sbjct: 1889 LKR----QLEEAEEESQRINANRRKLQRE 1913
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 68.9 bits (167), Expect = 2e-11
Identities = 99/495 (20%), Positives = 208/495 (42%), Gaps = 71/495 (14%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
Q R ++E+ + DEL+ +E ++ + L+Q Q +L + T
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK----NLLQEQLQAETE 908
Query: 181 LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQG---ELEAQREAERQR---- 233
L + +A KKQE +EE+L E+ A+L+ + +L+A+R+ Q+
Sbjct: 909 LYAEAEEMRVRLA----AKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 234 --QLQEAELIHQR----EIEAKKEFDKWKEQ------EWTKLYGEIDKLKKLFWDEFKNV 281
QL+E E Q+ ++ A+ + K +++ + KL E L++ D N+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 282 AKQNSTLEEKLRALQSHSVMESKLG-SLRDEESEEWLRQARELQALREKTEIQKTEWKRK 340
A++ + + H M S+L L+ EE + +EL+ L+ K E +++ +
Sbjct: 1023 AEEEEKAKNLTKLKNKHESMISELEVRLKKEE-----KSRQELEKLKRKLEGDASDFHEQ 1077
Query: 341 VKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQC---------QISTLRAQL--- 388
+ +L + K +L ++ + LQA+L++ + A ++ IS L+ L
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 389 -------QEQARIIASQEEMI--------------QSLSLRKVEGIHKVPKAVDTEEDSP 427
++Q R + + E + Q L ++ + + + KA+D E S
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 428 EEEMEDSQDEQHKVLAALRRNPTLLKHFRPILE---DTLEEKLESMGIRKDAKGISIQTL 484
E ++++ + + + + L K + L+ TLE++ + G + Q +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 485 RHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
H + L Q ++ K S+ R +L +V E + +++ +G+ ++
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 545 ALVTREAQPKTRTLQ 559
A ++ + Q LQ
Sbjct: 1318 ASLSSQLQDTQELLQ 1332
Score = 60.1 bits (144), Expect = 8e-09
Identities = 96/475 (20%), Positives = 192/475 (40%), Gaps = 45/475 (9%)
Query: 83 LLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREE 142
L+ L Q + LL + +S+ A R + +++ L R +E +EE
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508
Query: 143 SRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQE 202
R KM+ + L+ + H +K + L ++ + E + +
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEE---LEDEL 1562
Query: 203 QPVEEVLEELRAKLKWTQGELEAQREA------ERQRQLQEAELIHQREIEAKKEFDKWK 256
Q E+ L ++ +G+ E +A E++RQLQ ++ E+E +++
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1622
Query: 257 EQEWTKLYGEIDKLK-------KLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLR 309
KL G++ L+ K + K + K + +++ R L+ ++ +
Sbjct: 1623 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682
Query: 310 DEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE--------KKELQEENQR 361
E ++ +L L+E ++ E RK +L +E +AE + LQ+E +R
Sbjct: 1683 KENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 362 LQASLSQ-DQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
L+A ++Q +++ Q + + R + Q S E + + +K E + +
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800
Query: 421 DTEEDSPEEEMEDSQDEQHK-VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDA--K 477
+ E S EME + + K +AAL LEE++E K A K
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQVEQEAREKQAATK 1849
Query: 478 GISIQTLRHLESLLRVQREQK-ARKFSEFLSLRGKLVKEVTSRAKERQENGAAVS 531
+ + + E LL+V+ E+K A ++ E VK++ + +E +E ++
Sbjct: 1850 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Score = 58.2 bits (139), Expect = 3e-08
Identities = 85/383 (22%), Positives = 167/383 (43%), Gaps = 45/383 (11%)
Query: 201 QEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEW 260
+E+ ++ + + A +G L + A+RQ+QL ++I QR A + W +W
Sbjct: 786 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVI-QRNCAAYLKLRNW---QW 841
Query: 261 TKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQA 320
+L+ ++ L ++ E + AK++ + K R ++ E++L L + S+
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQ----LT 893
Query: 321 RELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQ 380
E L+E+ + + TE + +E+ A+K+EL+E ++A L +++ + Q Q +
Sbjct: 894 EEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAE 951
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
+ Q+ + + +E Q L L KV K+ K E+E+ D+ +K
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL--------EDEILVMDDQNNK 1003
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKAR 500
L + LL+ L L E+ E K + LE +R+++E+K+R
Sbjct: 1004 ----LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKEEKSR 1057
Query: 501 KFSEFL----------------SLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
+ E L L+ ++ + AK+ +E AA+++ D + + K+
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117
Query: 545 ALVTREAQPKTRTLQVALPSTPA 567
+ RE + LQ L S A
Sbjct: 1118 KKI-RELEGHISDLQEDLDSERA 1139
Score = 58.2 bits (139), Expect = 3e-08
Identities = 106/502 (21%), Positives = 214/502 (42%), Gaps = 80/502 (15%)
Query: 108 VAQLEARLQTSLGQQQRGQQELGRQADELKG----VREESRRRRKMISTLQ-QLLMQTGT 162
+++LE RL+ ++++ +QEL + +L+G E+ + I+ L+ QL +
Sbjct: 1043 ISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1098
Query: 163 HSYHTCHLCDKTFMNATFLR------GHIQRRHAGV----AEGGKQKKQEQPVEEVLEEL 212
L D+ L+ GHI + A K +KQ++ + E LE L
Sbjct: 1099 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1158
Query: 213 RAKLK------WTQGELEAQREAE---RQRQLQEAELIHQREIEAKKEFDKWKEQEWTKL 263
+ +L+ TQ EL A+RE E ++ L E H+ +++ ++ +E T+
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1218
Query: 264 YGEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEESEEWLRQARE 322
+ + K + + K+N+ L +LR L Q+ +E K L Q +E
Sbjct: 1219 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--------AQVQE 1270
Query: 323 LQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQIS 382
LQ+ E + E KV +LQ E + + L++ + KA ++ ++
Sbjct: 1271 LQSKCSDGERARAELNDKV-----------HKLQNEVESVTGMLNEAEGKAIKLAK-DVA 1318
Query: 383 TLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQD-EQH-- 439
+L +QLQ+ ++ QEE Q L++ + ++ + ++ +D +EEME Q+ E+H
Sbjct: 1319 SLSSQLQDTQELL--QEETRQKLNVS--TKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1374
Query: 440 KVLAALRRNPTLLKHFRPILE------DTLEEKLESMGIRKDAKGISIQTLRHLESLLRV 493
+ L + L+ F +E ++++E++ + + K + L ++ L+
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 494 Q-----------------REQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQ 536
+ E+K RKF + L+ K + + ++R E A +
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 537 PSVKSQQSALVTREAQPKTRTL 558
++ + AL +E +T +
Sbjct: 1494 SLARALEEALEAKEELERTNKM 1515
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/269 (19%), Positives = 117/269 (43%), Gaps = 21/269 (7%)
Query: 114 RLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDK 173
+LQ + QR ++ DE+ +E+ ++ K +L+ LMQ ++
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQL----QEDLAAAER 1708
Query: 174 TFMNATFLRGHIQRRHAGVAEGGKQKKQEQP-VEEVLEELRAKLKWTQGELEAQREAERQ 232
A + + A G + E+ +E + +L +L+ QG +EA + R+
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1768
Query: 233 RQLQEAELIH---------QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAK 283
Q +L + Q+ A+++ ++ ++ +KL+ +K F +
Sbjct: 1769 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 284 QNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE 343
+ + LEE++ +K +D++ +E L Q + + + E+ + Q + +VK+
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1888
Query: 344 LHEEHMAEKKELQEENQRLQASLSQDQKK 372
L + +E +EE+QR+ A+ + Q++
Sbjct: 1889 LKR----QLEEAEEESQRINANRRKLQRE 1913
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 68.9 bits (167), Expect = 2e-11
Identities = 99/495 (20%), Positives = 208/495 (42%), Gaps = 71/495 (14%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
Q R ++E+ + DEL+ +E ++ + L+Q Q +L + T
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEK----NLLQEQLQAETE 901
Query: 181 LRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQG---ELEAQREAERQR---- 233
L + +A KKQE +EE+L E+ A+L+ + +L+A+R+ Q+
Sbjct: 902 LYAEAEEMRVRLA----AKKQE--LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 234 --QLQEAELIHQR----EIEAKKEFDKWKEQ------EWTKLYGEIDKLKKLFWDEFKNV 281
QL+E E Q+ ++ A+ + K +++ + KL E L++ D N+
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 282 AKQNSTLEEKLRALQSHSVMESKLG-SLRDEESEEWLRQARELQALREKTEIQKTEWKRK 340
A++ + + H M S+L L+ EE + +EL+ L+ K E +++ +
Sbjct: 1016 AEEEEKAKNLTKLKNKHESMISELEVRLKKEE-----KSRQELEKLKRKLEGDASDFHEQ 1070
Query: 341 VKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQC---------QISTLRAQL--- 388
+ +L + K +L ++ + LQA+L++ + A ++ IS L+ L
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 389 -------QEQARIIASQEEMI--------------QSLSLRKVEGIHKVPKAVDTEEDSP 427
++Q R + + E + Q L ++ + + + KA+D E S
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 428 EEEMEDSQDEQHKVLAALRRNPTLLKHFRPILE---DTLEEKLESMGIRKDAKGISIQTL 484
E ++++ + + + + L K + L+ TLE++ + G + Q +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 485 RHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
H + L Q ++ K S+ R +L +V E + +++ +G+ ++
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 545 ALVTREAQPKTRTLQ 559
A ++ + Q LQ
Sbjct: 1311 ASLSSQLQDTQELLQ 1325
Score = 60.1 bits (144), Expect = 8e-09
Identities = 96/475 (20%), Positives = 192/475 (40%), Gaps = 45/475 (9%)
Query: 83 LLKVLRLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREE 142
L+ L Q + LL + +S+ A R + +++ L R +E +EE
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 143 SRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQE 202
R KM+ + L+ + H +K + L ++ + E + +
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKTQLEE---LEDEL 1555
Query: 203 QPVEEVLEELRAKLKWTQGELEAQREA------ERQRQLQEAELIHQREIEAKKEFDKWK 256
Q E+ L ++ +G+ E +A E++RQLQ ++ E+E +++
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALA 1615
Query: 257 EQEWTKLYGEIDKLK-------KLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLR 309
KL G++ L+ K + K + K + +++ R L+ ++ +
Sbjct: 1616 AAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675
Query: 310 DEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE--------KKELQEENQR 361
E ++ +L L+E ++ E RK +L +E +AE + LQ+E +R
Sbjct: 1676 KENEKKAKSLEADLMQLQE--DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 362 LQASLSQ-DQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
L+A ++Q +++ Q + + R + Q S E + + +K E + +
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793
Query: 421 DTEEDSPEEEMEDSQDEQHK-VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDA--K 477
+ E S EME + + K +AAL LEE++E K A K
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIA-----------QLEEQVEQEAREKQAATK 1842
Query: 478 GISIQTLRHLESLLRVQREQK-ARKFSEFLSLRGKLVKEVTSRAKERQENGAAVS 531
+ + + E LL+V+ E+K A ++ E VK++ + +E +E ++
Sbjct: 1843 SLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Score = 58.2 bits (139), Expect = 3e-08
Identities = 85/383 (22%), Positives = 167/383 (43%), Gaps = 45/383 (11%)
Query: 201 QEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEW 260
+E+ ++ + + A +G L + A+RQ+QL ++I QR A + W +W
Sbjct: 779 EEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVI-QRNCAAYLKLRNW---QW 834
Query: 261 TKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQA 320
+L+ ++ L ++ E + AK++ + K R ++ E++L L + S+
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKA----ENELKELEQKHSQ----LT 886
Query: 321 RELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQ 380
E L+E+ + + TE + +E+ A+K+EL+E ++A L +++ + Q Q +
Sbjct: 887 EEKNLLQEQLQAE-TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-GQQLQAE 944
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
+ Q+ + + +E Q L L KV K+ K E+E+ D+ +K
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKL--------EDEILVMDDQNNK 996
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKAR 500
L + LL+ L L E+ E K + LE +R+++E+K+R
Sbjct: 997 ----LSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE--VRLKKEEKSR 1050
Query: 501 KFSEFL----------------SLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQS 544
+ E L L+ ++ + AK+ +E AA+++ D + + K+
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110
Query: 545 ALVTREAQPKTRTLQVALPSTPA 567
+ RE + LQ L S A
Sbjct: 1111 KKI-RELEGHISDLQEDLDSERA 1132
Score = 58.2 bits (139), Expect = 3e-08
Identities = 106/502 (21%), Positives = 214/502 (42%), Gaps = 80/502 (15%)
Query: 108 VAQLEARLQTSLGQQQRGQQELGRQADELKG----VREESRRRRKMISTLQ-QLLMQTGT 162
+++LE RL+ ++++ +QEL + +L+G E+ + I+ L+ QL +
Sbjct: 1036 ISELEVRLK----KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE 1091
Query: 163 HSYHTCHLCDKTFMNATFLR------GHIQRRHAGV----AEGGKQKKQEQPVEEVLEEL 212
L D+ L+ GHI + A K +KQ++ + E LE L
Sbjct: 1092 LQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEAL 1151
Query: 213 RAKLK------WTQGELEAQREAE---RQRQLQEAELIHQREIEAKKEFDKWKEQEWTKL 263
+ +L+ TQ EL A+RE E ++ L E H+ +++ ++ +E T+
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQ 1211
Query: 264 YGEIDKLKKLFWDEFKNVAKQNSTLEEKLRAL-QSHSVMESKLGSLRDEESEEWLRQARE 322
+ + K + + K+N+ L +LR L Q+ +E K L Q +E
Sbjct: 1212 LEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE--------AQVQE 1263
Query: 323 LQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQIS 382
LQ+ E + E KV +LQ E + + L++ + KA ++ ++
Sbjct: 1264 LQSKCSDGERARAELNDKV-----------HKLQNEVESVTGMLNEAEGKAIKLAK-DVA 1311
Query: 383 TLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQD-EQH-- 439
+L +QLQ+ ++ QEE Q L++ + ++ + ++ +D +EEME Q+ E+H
Sbjct: 1312 SLSSQLQDTQELL--QEETRQKLNVS--TKLRQLEEERNSLQDQLDEEMEAKQNLERHIS 1367
Query: 440 KVLAALRRNPTLLKHFRPILE------DTLEEKLESMGIRKDAKGISIQTLRHLESLLRV 493
+ L + L+ F +E ++++E++ + + K + L ++ L+
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 494 Q-----------------REQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQ 536
+ E+K RKF + L+ K + + ++R E A +
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA-EEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 537 PSVKSQQSALVTREAQPKTRTL 558
++ + AL +E +T +
Sbjct: 1487 SLARALEEALEAKEELERTNKM 1508
Score = 46.2 bits (108), Expect = 1e-04
Identities = 52/269 (19%), Positives = 117/269 (43%), Gaps = 21/269 (7%)
Query: 114 RLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDK 173
+LQ + QR ++ DE+ +E+ ++ K +L+ LMQ ++
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQL----QEDLAAAER 1701
Query: 174 TFMNATFLRGHIQRRHAGVAEGGKQKKQEQP-VEEVLEELRAKLKWTQGELEAQREAERQ 232
A + + A G + E+ +E + +L +L+ QG +EA + R+
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRK 1761
Query: 233 RQLQEAELIH---------QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAK 283
Q +L + Q+ A+++ ++ ++ +KL+ +K F +
Sbjct: 1762 ATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 284 QNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE 343
+ + LEE++ +K +D++ +E L Q + + + E+ + Q + +VK+
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQ 1881
Query: 344 LHEEHMAEKKELQEENQRLQASLSQDQKK 372
L + +E +EE+QR+ A+ + Q++
Sbjct: 1882 LKR----QLEEAEEESQRINANRRKLQRE 1906
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 68.6 bits (166), Expect = 2e-11
Identities = 100/478 (20%), Positives = 201/478 (42%), Gaps = 28/478 (5%)
Query: 101 QDCLSASVAQLEARLQ------TSLGQQQRGQQELGRQAD-ELKGVREESRRRRKMISTL 153
++ L +A+ E R + T L Q + +E G + +L+ ++EE +K +S
Sbjct: 640 RNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES 699
Query: 154 QQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELR 213
+ + T H + L +Q + A V E + + Q VE ++L
Sbjct: 700 RHQ-QEAATTQLEQLH--QEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLA 756
Query: 214 AKLKWTQGELEAQREA--ERQRQLQEAELIHQR---EIEAKKEFDKWKEQEWTKLYGEID 268
+L+ E + E Q+Q E+ + +I+ + + + E L E+D
Sbjct: 757 EQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELD 816
Query: 269 KLKKLFWDEFKNVAKQNSTLEE--KLRALQSHSVMESKLGSLRDEESEEWLRQARELQAL 326
+ E A+Q + E+ K Q + E ++ LR++ +E +EL
Sbjct: 817 TERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKA 876
Query: 327 REKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRA 386
E E +K E + ++KE E A + + +EE + +++L Q Q + + + TL
Sbjct: 877 LESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ 936
Query: 387 QLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALR 446
+E A E + Q + ++K++ + + T+ + E++++ + LAAL+
Sbjct: 937 TQKELADASQQLERLRQDMKVQKLKE-QETTGILQTQLQEAQRELKEAARQHRDDLAALQ 995
Query: 447 RNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQ----TLRHLESLLRVQREQKARKF 502
+ L + L+ +E+ + + D++ + Q LR + R+Q+E + K
Sbjct: 996 EESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKA 1055
Query: 503 SEFLSLRGK-----LVKEVTS-RAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPK 554
S LSL K +++E S R +E + + G+ S Q L+ +E + K
Sbjct: 1056 SLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK 1113
Score = 62.0 bits (149), Expect = 2e-09
Identities = 100/480 (20%), Positives = 193/480 (40%), Gaps = 41/480 (8%)
Query: 106 ASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSY 165
A +Q+ LQ Q + Q+E + + + E + +++LQ L +
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 166 HTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEA 225
+ L ++ A V E Q +EE L R+ LK E+E+
Sbjct: 1338 EAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVES 1397
Query: 226 QRE----AERQRQLQEAE-LIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKK-------- 272
+RE + Q +L+ A+ Q + + +E+E L G+I +L+K
Sbjct: 1398 ERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAA 1457
Query: 273 --LFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKT 330
L + K ++ +E+++ L+ + L E ++ Q +++ L +
Sbjct: 1458 LELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDR 1517
Query: 331 EIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQE 390
E Q+ + ++ EL EKK+ E+QR Q QD KK +C L +L+E
Sbjct: 1518 ETQRNVLEHQLLEL------EKKDQMIESQRGQV---QDLKKQLVTLEC----LALELEE 1564
Query: 391 QARIIASQEEMIQSL-SLRKVEGIHKVPKAVDTEEDSPEEEMEDSQD---EQHKVLAA-- 444
+ Q+++I+ L R+ + + +D EE S E + + SQ E H + A
Sbjct: 1565 NHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARE 1624
Query: 445 LRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSE 504
L+ +K R +E+ L+ + E + + + + + +L QR ++ + E
Sbjct: 1625 LQERDQEVKSQREQIEE-LQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEE 1683
Query: 505 -----FLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
LSLR + +E+T++ + QE P + L+ R+ + + Q
Sbjct: 1684 DLEQIKLSLRER-GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQ 1742
Score = 60.8 bits (146), Expect = 4e-09
Identities = 108/537 (20%), Positives = 219/537 (40%), Gaps = 75/537 (13%)
Query: 101 QDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLL--- 157
+D + +AQ E +T+L QQ+ ++ Q E K +E S ++++ L+ L
Sbjct: 826 RDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE-KWEKERSWHQQELAKALESLEREK 884
Query: 158 ---------MQTGTHSYHTCHLCDKTFMNATFLRGHIQ--RRHAGVAEGGKQKKQE-QPV 205
QT + ++T + + ++ + + E Q ++E
Sbjct: 885 MELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADA 944
Query: 206 EEVLEELRAKLKW-------TQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQ 258
+ LE LR +K T G L+ Q + E QR+L+EA H+ ++ A +E Q
Sbjct: 945 SQQLERLRQDMKVQKLKEQETTGILQTQLQ-EAQRELKEAARQHRDDLAALQEESSSLLQ 1003
Query: 259 EWTKLYGEIDKLKK--LFWDEFKNVAKQNSTLEEKLRALQSHSVMESKL----------- 305
+ L +++ LK + D+ + + +Q ++EKLR Q ++ ++ +L
Sbjct: 1004 DKMDLQKQVEDLKSQLVAQDDSQRLVEQE--VQEKLRETQEYNRIQKELEREKASLTLSL 1061
Query: 306 -------------GSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEK 352
S+R +E + +E Q +++ Q +++VKE + +A++
Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Query: 353 KELQEE-------NQRLQASLSQDQKKAA------AQSQCQISTLRAQLQ--EQARIIAS 397
+L EE Q+L+ASL + KAA ++ Q+ L A+ Q QA+ A
Sbjct: 1122 AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181
Query: 398 QEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRP 457
+ +L P+ + +P + + +Q+ + +R P L
Sbjct: 1182 LASLYSALQQALGSVCESRPELSGGGDSAP--SVWGLEPDQNGARSLFKRGPLLTALSAE 1239
Query: 458 ILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVT 517
+ L + + + + + + ++ LE L +K++ +E L+ +L +
Sbjct: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE 1299
Query: 518 SRAK-ERQENGAAVSQPDGQPSVKSQQS-----ALVTREAQPKTRTLQVALPSTPAE 568
++K E ++N + ++ S QS L EAQ + LQ A + A+
Sbjct: 1300 EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQ 1356
Score = 60.1 bits (144), Expect = 8e-09
Identities = 70/286 (24%), Positives = 132/286 (46%), Gaps = 23/286 (8%)
Query: 196 GKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKW 255
G+ + Q+ +E +++L+ L EL Q+E E+ + A+ + + I+ K+ +
Sbjct: 2024 GEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQE 2083
Query: 256 KEQEWTK-LYGEIDKLKKLFWDEFKNVAKQNSTLE-EKLRAL-QSHSVMESKLGSLRDEE 312
+E+E + L+ + +L+ + + + + T + L AL SH + SL+ +
Sbjct: 2084 REEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143
Query: 313 SEEWL-RQARELQALREKTEIQKTEWKRKVKELH---EEHMAEKKELQEENQRLQAS-LS 367
E L R+ LQA +TE ++ EW+ K ++L + A LQE LQAS L
Sbjct: 2144 LEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLE 2203
Query: 368 QDQKKAAAQSQCQISTLRAQLQEQARI--------IASQEEMIQSLSLRKVEGIHKVPKA 419
+D ++ Q + ++ T RA +E+ + S+ E Q + L +V G+ P
Sbjct: 2204 RDSEQQRLQDELEL-TRRALEKERLHSPGATSTAELGSRGE--QGVQLGEVSGVEAEPSP 2260
Query: 420 VDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEE 465
E+ S + +E Q + +A L + + L+ L TLE+
Sbjct: 2261 DGMEKQSWRQRLEHLQ----QAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Score = 52.4 bits (124), Expect = 2e-06
Identities = 88/393 (22%), Positives = 171/393 (43%), Gaps = 56/393 (14%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQRE-AERQRQLQEAEL-IHQREIEAKKEFDK 254
K +++ + EVLE+ +L+ EL+ Q + A+ Q++ Q+ EL + RE E +E
Sbjct: 470 KAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLM 529
Query: 255 WKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKL-------------RALQSHSVM 301
E + ++ E+ L++ A ++S LE +L RA QS + +
Sbjct: 530 GLEAKQSESLSELITLRE---------ALESSHLEGELLRQEQTEVTAALARAEQSIAEL 580
Query: 302 ESKLGSLRDEESEEWLRQAR-ELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQ 360
S +L+ E ++ LR A +L AL E + K +++ +L EE+ + ++ Q
Sbjct: 581 SSSENTLKTEVAD--LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQ 638
Query: 361 ---RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP 417
LQ L++ +K+ A + + + L AQLQ+ A + ++ + K E K+
Sbjct: 639 ARNALQVDLAEAEKRREALWE-KNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLS 697
Query: 418 KAVDTEEDSPE--EEMEDSQDEQHKVLAALRRNPTLLKHFRPILE----------DTLEE 465
++ +E + E++ Q +VLA + L + LE L E
Sbjct: 698 ESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAE 757
Query: 466 KLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEV--------T 517
+L+ + K+ S+ + S++ V + Q + + + EV T
Sbjct: 758 QLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDT 817
Query: 518 SRAKERQENGAAVSQ-----PDGQPSVKSQQSA 545
R++ QE AA Q +G+ +++ Q++A
Sbjct: 818 ERSQAEQERDAAARQLAQAEQEGKTALEQQKAA 850
Score = 52.4 bits (124), Expect = 2e-06
Identities = 100/473 (21%), Positives = 192/473 (40%), Gaps = 100/473 (21%)
Query: 111 LEARLQTSLGQQQRGQ-QELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCH 169
LE + + + QRGQ Q+L +Q L+ + E + Q+L+ +
Sbjct: 1529 LELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR----- 1583
Query: 170 LCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREA 229
+ + T L ++ R E Q Q +E L +L+ E+++QRE
Sbjct: 1584 --ETQRVALTHLTLDLEERSQ---ELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQ 1638
Query: 230 ERQRQLQEAELIHQ-----REIEAKKEFDKWKEQEWTK----LYGEIDKLKKLFWDEFKN 280
+ Q Q+ L +E+ +KE + E + T+ L +++++K + +
Sbjct: 1639 IEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRE 1698
Query: 281 VAKQNSTLEEKLRALQSHSVMESKLGSL-------RDEESEEWLRQAR--ELQALREKTE 331
+ Q ++E RA + +++ GSL RD+E E +Q ELQ L+++ E
Sbjct: 1699 LTTQRQLMQE--RAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLE 1756
Query: 332 IQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQ 391
Q RKV E L + ++ L Q ++A Q + + +L++QL E
Sbjct: 1757 QQLQGLHRKV--------GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEA 1808
Query: 392 ARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTL 451
R +A +++ +++L ++E + +Q ++ +V
Sbjct: 1809 QRALAQRDQELEAL----------------------QQEQQQAQGQEERV---------- 1836
Query: 452 LKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGK 511
K L+ LE+ + TL+ L+ +EQ AR+ E L++ G+
Sbjct: 1837 -KEKADALQGALEQ--------------AHMTLKERHGELQDHKEQ-ARRLEEELAVEGR 1880
Query: 512 LVKEVTS-----RAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
V+ + RA+ R++ A ++ QQ A +E + +TR LQ
Sbjct: 1881 RVQALEEVLGDLRAESREQEKALLA--------LQQQCAEQAQEHEVETRALQ 1925
Score = 52.0 bits (123), Expect = 2e-06
Identities = 110/514 (21%), Positives = 193/514 (37%), Gaps = 76/514 (14%)
Query: 112 EARLQTSLGQQQRG----QQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHT 167
E LQ+ L + QR QEL E + + + R ++ LQ L Q
Sbjct: 1798 EQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA------- 1850
Query: 168 CHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQR 227
H+ K L+ H ++ E + ++ Q +EEVL +LRA E Q
Sbjct: 1851 -HMTLKERHGE--LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRA-------ESREQE 1900
Query: 228 EAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNST 287
+A Q Q AE + E+E + D W + + V K+
Sbjct: 1901 KALLALQQQCAEQAQEHEVETRALQDSWLQAQ--------------------AVLKERDQ 1940
Query: 288 LEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEE 347
E LRA S + + R E +E L +A +E+ +++ E R ++
Sbjct: 1941 ELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTAT 2000
Query: 348 HMAEKKELQ------EENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEM 401
A Q EE R+Q QDQ + Q+ AQ E+ R +E++
Sbjct: 2001 LQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQL 2060
Query: 402 IQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILED 461
++ ++V+ + + + + ++ EEE+ ++ L + + R E
Sbjct: 2061 LEKSLAQRVQE-NMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELR---ET 2116
Query: 462 TLEEKLESMGIRKDAKGISIQTLRHLESL-LRVQREQKARKFSEFLSLRGKLVKEVTSRA 520
LE++ + Q+L+ L+SL R+QRE + + +LR +E+ R
Sbjct: 2117 QQRNNLEALPHSHKTSPMEEQSLK-LDSLEPRLQRELERLQ----AALRQTEAREIEWRE 2171
Query: 521 KERQENGAAVSQPDGQPSVKS-------QQSALVTREAQPK---------TRTLQVALPS 564
K + A+S + SV S Q++++ R+++ + R L+
Sbjct: 2172 KAQD---LALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH 2228
Query: 565 TPAEPPPPTRQSHGSHGSSLTQVSAPAPHPGLHG 598
+P S G G L +VS P G
Sbjct: 2229 SPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDG 2262
Score = 35.8 bits (81), Expect = 0.15
Identities = 73/329 (22%), Positives = 130/329 (39%), Gaps = 46/329 (13%)
Query: 119 LGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNA 178
L QQ+ + +LK +E +R+ ++ LQ ++Q + C +
Sbjct: 25 LALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSW-------CQELEKRL 77
Query: 179 TFLRGHIQRRHAGVAEGGKQK-----KQEQPVEEVLEELRAKLKWTQGELEAQREAERQR 233
G I +R V E + ++EQ E L E+ +L+ + + +A R+
Sbjct: 78 EATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALRED 137
Query: 234 -QLQEAELIHQREIEAKKEFDKWKEQEWTKLY--GEIDKLKKLFWDEF----KNVAKQNS 286
+ + R+ +KE EQE+ K Y GE +L L W E ++ + S
Sbjct: 138 VEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSL-WREVVTFRRHFLEMKS 196
Query: 287 TLEEKLRALQSHSVMES----------KLGSLRDEESEEWLRQARE------LQALREKT 330
+ L L++ V S +G+ E + RE L A ++
Sbjct: 197 ATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQEL 256
Query: 331 EIQKTEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQK---------KAAAQSQCQI 381
E + E +++ +L + EK ELQ+ L A L+Q QK KA ++ +
Sbjct: 257 EKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEIL 316
Query: 382 STLRAQLQEQARIIASQEEMIQSLSLRKV 410
T +L E + S+ + LSL++V
Sbjct: 317 ETNHTELMEHEASL-SRNAQEEKLSLQQV 344
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 68.6 bits (166), Expect = 2e-11
Identities = 79/346 (22%), Positives = 159/346 (45%), Gaps = 30/346 (8%)
Query: 196 GKQKKQEQPV---EEVLEELRAKLKWTQGELEAQ---REAERQRQLQEAELIHQREIEAK 249
GK ++QE+ + E+ L E +L+ + EL Q RE E Q Q QE ++ Q E +
Sbjct: 307 GKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMRE 366
Query: 250 KEFDKWKEQE--WTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGS 307
+E W+++E W + ++ +K+ D+ + + +Q+ L EK ++ M ++
Sbjct: 367 QEEKMWRQEERLWEQEKQMREQEQKMR-DQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Query: 308 LRDEES--EEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQRLQAS 365
+R+E+ E+ + + + ++E+ I++ E K + +E EK + QEEN Q
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485
Query: 366 LSQDQKKAAAQS-----QCQISTLRAQLQEQARIIASQEEMI-QSLSLRKVEGIHKVPKA 419
Q++ Q Q ++ ++ EQ I QEEM Q + + E + +
Sbjct: 486 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE---- 541
Query: 420 VDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGI 479
+ED E+ E +D++ K+ R + D E+ E +R+ K
Sbjct: 542 ---QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK-- 596
Query: 480 SIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQE 525
+R E ++R ++E+K ++ E + + + + E + +E++E
Sbjct: 597 ---KMREEEEMMR-EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638
Score = 62.4 bits (150), Expect = 2e-09
Identities = 82/387 (21%), Positives = 178/387 (45%), Gaps = 60/387 (15%)
Query: 104 LSASVAQLEARLQTS---LGQQQRG--QQELGRQADELKGVREESRRRR-KMISTLQQLL 157
+ +V +L+ +L+ + L Q Q Q+E+ RQ +EL+ ++ R++ KM ++L
Sbjct: 244 IQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR 303
Query: 158 MQTGTHSYHTCHLCDKTFMNATFLRGH---IQRRHAGVAEGGKQKKQEQPVEEVLEEL-- 212
Q G +K + LR ++ + + E + ++QE+ ++E E++
Sbjct: 304 EQEGKMREQE----EKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359
Query: 213 -------RAKLKWTQ----GELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWT 261
+ + W Q E E Q + Q+ + E + +++ +++ ++ +EQE
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQE-- 417
Query: 262 KLYGEIDKLK--KLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLR---------- 309
K++ +++K++ K ++ K Q ++E+ R + M + ++R
Sbjct: 418 KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE 477
Query: 310 ----DEESEEWLRQ--ARELQALREKTEIQKTE---WKRKVKELHEEHM--AEKKELQEE 358
++E +EW +Q + + L E+ ++Q+ E W+++ K +E M EKK ++E
Sbjct: 478 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 537
Query: 359 NQRLQA-SLSQDQKKAAAQSQ---CQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIH 414
R Q + + ++K Q Q Q + + QEQ + QEE +R+ E +
Sbjct: 538 KMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEE-----KMREEERMR 592
Query: 415 KVPKAVDTEEDSPEEEMEDSQDEQHKV 441
+ K + EE+ E+ E Q+++ K+
Sbjct: 593 EREKKMREEEEMMREQEEKMQEQEEKM 619
Score = 60.8 bits (146), Expect = 4e-09
Identities = 52/261 (19%), Positives = 132/261 (50%), Gaps = 18/261 (6%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGEL--EAQREAERQRQL-QEAELIHQREIEAKKEFD 253
K QE+ +E+ +E + K W Q E E +R ER++++ +E E++ ++E + +++ +
Sbjct: 559 KMWDQEERMEKKTQE-QEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617
Query: 254 KWKEQEWTKLYGEIDKLKKL----------FWDEFKNVAKQNSTLEEKLRALQSHSVMES 303
K +EQE K++ + +K+++ W++ + + +Q E+K + + + E
Sbjct: 618 KMQEQE-EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 676
Query: 304 KLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKEL---QEENQ 360
+ ++E+ E + ++ Q +KT Q+ + + E+ M E++E+ QEE
Sbjct: 677 EKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM 736
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
+ Q Q+Q++ + + ++ ++ EQ R+ +E++ + +++ E I + + +
Sbjct: 737 QEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKM 796
Query: 421 DTEEDSPEEEMEDSQDEQHKV 441
+E+ + E + ++ K+
Sbjct: 797 RDQEEKMRGQEEKMRGQEEKM 817
Score = 60.1 bits (144), Expect = 8e-09
Identities = 76/356 (21%), Positives = 151/356 (42%), Gaps = 72/356 (20%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKK------ 250
K + QE+ ++E E +R + K + E E RE E + Q QE + Q E E ++
Sbjct: 438 KTRDQEEKMQEE-ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 496
Query: 251 -----EFDKWKEQEWTKLYGEIDKLK--KLFWDEFKNVAKQNSTLEEKLRALQSHSVMES 303
E +K +EQE K++ + +K++ + W + K + +Q EK+R + M
Sbjct: 497 KEKLWEQEKMQEQE-EKIWEQEEKIRDQEEMWGQEKKMWRQ-----EKMR--EQEDQMWE 548
Query: 304 KLGSLRDEESEEWLRQAR--------------ELQALREKTEIQKTEWKRKVKELHEEHM 349
+ +RD+E + W ++ R + + +RE+ +++ E K + +E
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ 608
Query: 350 AEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRK 409
EK + QEE + Q +Q++ ++QEQ + QEE + +
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEE--------------KMQEQEEKMWEQEEKMWEQEEKM 654
Query: 410 VEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLES 469
E + E +E E Q+++ K+ +EK+E
Sbjct: 655 WEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWE--------------------QEKMEK 694
Query: 470 MGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQE 525
++ K + +R ES+ +RE+K R+ E + + + ++E + +E++E
Sbjct: 695 KTQEQEKKTWDQEKMREEESMR--EREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Score = 52.4 bits (124), Expect = 2e-06
Identities = 58/289 (20%), Positives = 140/289 (48%), Gaps = 50/289 (17%)
Query: 185 IQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREA--ERQRQLQEAELIH 242
+Q++ + E +++ Q+Q + E E+L W Q +++ Q E E++ ++++ E +
Sbjct: 473 MQKQEENMWEQEEKEWQQQRLPEQKEKL-----WEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 243 QREIEAKKEFDKWKEQEWTKLYGEIDKLK---KLFWDEFKNVAKQNSTLEEKLRALQSHS 299
+E + ++ +K +EQE +++ + +K++ + WD+ + + K+ E+K +
Sbjct: 528 GQEKKMWRQ-EKMREQE-DQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKM 585
Query: 300 VMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEEN 359
E ++ E E+ +R+ E+ +RE+ E + E + K++E E+ +++++QE+
Sbjct: 586 REEERM-----REREKKMREEEEM--MREQEE-KMQEQEEKMQEQEEKMWEQEEKMQEQE 637
Query: 360 QRL----------------QASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQ 403
+++ Q L + ++K + Q + ++QEQ I QE+M +
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ---EQEKMQEQEEKIWEQEKMEK 694
Query: 404 SL-----------SLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKV 441
+R+ E + + K + EE+ E+ E Q+++ K+
Sbjct: 695 KTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKM 743
Score = 45.4 bits (106), Expect = 2e-04
Identities = 44/229 (19%), Positives = 112/229 (48%), Gaps = 22/229 (9%)
Query: 189 HAGVAEGGKQKKQEQPV--EEVLEELRAKLKWTQGELEAQREAERQRQ-----LQEAELI 241
H + E K ++QE+ + +E +E+ + + + E RE E R+ +E E++
Sbjct: 670 HEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMM 729
Query: 242 HQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVM 301
++E + +++ +K +EQE E+ + ++ W++ + + +Q E+K + + +
Sbjct: 730 REQEEKMQEQEEKMQEQE-----EEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQ 784
Query: 302 ESKL-----GSLRDEESEEWLRQARELQALREKTEIQKTE-W--KRKVKELHEEHMAEKK 353
E + +RD+E E+ Q +++ EK Q+ + W + K+ E+ +++
Sbjct: 785 EQEKIWEQEEKMRDQE-EKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 843
Query: 354 ELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMI 402
++ + ++++ + ++K Q + ++ +++EQ + QEE I
Sbjct: 844 KMWGQEEKMEEKMQGQEEKMREQEE-KMRGQEEKMREQEEKMRGQEEKI 891
Score = 39.3 bits (90), Expect = 0.014
Identities = 64/324 (19%), Positives = 140/324 (43%), Gaps = 51/324 (15%)
Query: 230 ERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLE 289
E QR L H++ +E K ++ +LY ++L K+N+ L+
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEEL--------KKKNAELQ 231
Query: 290 EKLRALQSHSVMESKLGSLRDEESEEWLRQAREL-----------QALREKTEIQKTEWK 338
EKL +S E L +E + L +A+ L + R++ E+++ E K
Sbjct: 232 EKLPLAES----EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKK 287
Query: 339 RKVKE----LHEEHMAEK----KELQEENQRLQASLSQDQKKAAAQ-----SQCQISTLR 385
+ +E EE + E+ +E +E+ R + L + +K+ Q Q ++
Sbjct: 288 IRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQE 347
Query: 386 AQLQEQARIIASQEEMI---QSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVL 442
Q+QEQ + QEE + + R+ E + + K + + E++M D ++ +
Sbjct: 348 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQ----EQKMRDQEERMWEQD 403
Query: 443 AALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKF 502
LR ++ ++ + E++E M ++ K + Q + + ++Q E++ R+
Sbjct: 404 ERLREKEERMRE-----QEKMWEQVEKM---REEKKMQEQEKKTRDQEEKMQEEERIRER 455
Query: 503 SEFLSLRGKLVKEVTSRAKERQEN 526
+ + + ++E + ++++EN
Sbjct: 456 EKKMREEEETMREQEEKMQKQEEN 479
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 68.6 bits (166), Expect = 2e-11
Identities = 65/328 (19%), Positives = 159/328 (48%), Gaps = 24/328 (7%)
Query: 183 GHIQRRHAGVAEG-GKQKKQEQPVEEV---LEELRAKLKWTQGELEAQ----REAERQRQ 234
G ++ + V E G+ ++QE V E + E +++ +G++ Q RE E Q +
Sbjct: 115 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 174
Query: 235 LQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRA 294
QE + + ++E + +++ + EQE G++ + ++ ++ + + KQ + E+
Sbjct: 175 EQEGQ-VREQEGQVREQEGQMGEQE-----GQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ 228
Query: 295 LQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKE 354
++ E ++G ++E+ ++ Q ++ + K E Q E + +++E E+ + +K++
Sbjct: 229 MRKQ---EEQMGE-QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ 284
Query: 355 LQEENQR-LQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGI 413
++E Q Q ++Q++ + + Q+ Q++EQ + QEE + + E
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Query: 414 HKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIR 473
++ K + + EE+M+ +++ K +R+ ++ E+ + ++ E MG +
Sbjct: 345 EQMWKQ-EEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRK----QEEQMRKQEEQMGEQ 399
Query: 474 KDAKGISIQTLRHLESLLRVQREQKARK 501
K+ G + +R E + Q+EQ ++
Sbjct: 400 KEQMGEQKEQMREQEEQMGEQKEQMRKQ 427
Score = 59.7 bits (143), Expect = 1e-08
Identities = 55/233 (23%), Positives = 111/233 (47%), Gaps = 15/233 (6%)
Query: 186 QRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQRE 245
Q G E QK++EQ E+ EE K + GE E Q + + ++ ++ E + ++E
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQ--EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE 261
Query: 246 IEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKL 305
+ +++ ++ +EQE L K K+ E + ++ E++ + + M +
Sbjct: 262 EQMREQEEQMREQEEQML-----KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE 316
Query: 306 GSLRDEESEEWLRQARELQALREKTEIQKTE-WKRKVKELHEEHMAEKKE----LQEENQ 360
+R++E E+ +Q ++ +E+ QK + WK++ + +E +K+E QEE
Sbjct: 317 EQMREQE-EQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQM 375
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMI--QSLSLRKVE 411
R Q + Q++ + + Q+ + Q+ EQ + QEE + Q +RK E
Sbjct: 376 RKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428
Score = 58.5 bits (140), Expect = 2e-08
Identities = 76/374 (20%), Positives = 164/374 (43%), Gaps = 25/374 (6%)
Query: 183 GHIQRRHAGVAEG-GKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELI 241
G ++ + V E G+ ++QE V E ++R + + + RE E Q + QE + +
Sbjct: 52 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ-V 110
Query: 242 HQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVM 301
++E + +++ + +EQE G++ + + ++ V +Q + E Q V
Sbjct: 111 REQEGQVREQEGQVREQE-----GQVREQEGQVREQEGQVREQEGQVRE-----QEGQVR 160
Query: 302 ESKLGSLRDEESE--EWLRQARELQALREKTEIQKTEWKRKVKELHEE--HMAEKKELQE 357
E + G +R++E + E Q RE + + E Q E + ++ E E+ E+ + QE
Sbjct: 161 EQE-GQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE 219
Query: 358 ENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMI--QSLSLR-KVEGIH 414
E Q + Q++ + + Q+ Q+Q+Q + QEE + Q +R + E +
Sbjct: 220 EQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQML 279
Query: 415 KVPKAVDTEEDS--PEEEMEDSQDEQHKVLAALRRNPTLLKHFRPIL---EDTLEEKLES 469
K + + EE + EE+M + +++ + +R ++ + E+ + E+ E
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ 339
Query: 470 MGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAA 529
M +K+ + + E ++ Q EQ ++ + ++ K+ K+ ++ G
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQ 399
Query: 530 VSQPDGQPSVKSQQ 543
Q Q +Q
Sbjct: 400 KEQMGEQKEQMREQ 413
Score = 55.8 bits (133), Expect = 1e-07
Identities = 47/221 (21%), Positives = 111/221 (50%), Gaps = 11/221 (4%)
Query: 185 IQRRHAGVAEGGKQ-KKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQ 243
+Q++ + E +Q +KQE+ + E E+++ + + Q + E R+ E Q + QE ++ Q
Sbjct: 215 MQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQ 274
Query: 244 REIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSH-SVME 302
E + K+ ++ +++E T GE ++ + ++ + +Q EE++R + E
Sbjct: 275 EE-QMLKQKEQTEQEEQT---GEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQE 330
Query: 303 SKLGSLRD---EESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEEN 359
++ ++ E+ E+ +Q ++ E+ + Q+ + +++ +++ ++ E+ QEE
Sbjct: 331 EQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQE--EQMRKQEEQ 388
Query: 360 QRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEE 400
R Q +QK+ + + Q+ Q+ EQ + QEE
Sbjct: 389 MRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Score = 40.4 bits (93), Expect = 0.006
Identities = 46/241 (19%), Positives = 97/241 (40%), Gaps = 13/241 (5%)
Query: 313 SEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEENQ-RLQASLSQDQK 371
+EE + ELQ + E +K+E + +KEL + +K L +E Q R Q ++Q+
Sbjct: 6 NEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQE 65
Query: 372 KAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEM 431
+ + Q+ Q++EQ + QE + R+ EG + + E++ E
Sbjct: 66 GQVREQEGQVREQEGQVREQEGQVREQEGQV-----REQEGQVREQEGQVREQEGQVREQ 120
Query: 432 EDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLL 491
E EQ +R ++ + + + E G ++ +G +R E +
Sbjct: 121 EGQVREQE---GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG----QVREQEGQV 173
Query: 492 RVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREA 551
R Q Q + + G++ ++ ++ ++ G Q Q +Q + ++
Sbjct: 174 REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE 233
Query: 552 Q 552
+
Sbjct: 234 E 234
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 68.6 bits (166), Expect = 2e-11
Identities = 129/564 (22%), Positives = 225/564 (39%), Gaps = 118/564 (20%)
Query: 114 RLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTG------------ 161
RL+ L +QE L+G+ ++ R R+ L + L++
Sbjct: 506 RLERQLEDTVALRQEREDSTQRLRGLEKQHRVVRQEKEELHKQLVEASERLKSQAKELKD 565
Query: 162 THSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQE---QPVEEVLEELRAKLKW 218
H L + + +N Q++ K+++ E Q V+ + +E+R K
Sbjct: 566 AHQQRKLALQEFSELNERMAELRAQKQKVSRQLRDKEEEMEVATQKVDAMRQEMRRAEKL 625
Query: 219 TQGELEAQ-----REAERQRQLQEAELIHQREIEAKKEFDKWKE------------QEWT 261
+ ELEAQ EA ++R+L+E +++E++ E K K+ QE +
Sbjct: 626 RK-ELEAQLDDAVAEASKERKLREHSENFCKQMESELEALKVKQGGRGAGATLEHQQEIS 684
Query: 262 KLYGEIDKLKKLFWDE------------FKNVAKQNSTLEEKLRALQS------------ 297
K+ E++K K LF++E KNV K+ E ALQ
Sbjct: 685 KIKSELEK-KVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEILMLKDKLEKS 743
Query: 298 ----HSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKK 353
H+ ME +G+++D+ E E + L + E K+ ++ A+ +
Sbjct: 744 KRERHNEMEEAVGTIKDKYERERAMLFDENKKLTAENE--------KLCSFVDKLTAQNR 795
Query: 354 ELQEENQRLQASLSQDQKKAAAQSQCQISTL----------RAQLQEQARIIASQEEMIQ 403
+L++E Q L A +K++ A + QI+ + R LQ A + + E ++
Sbjct: 796 QLEDELQDLAA-----KKESVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELEALR 850
Query: 404 SLSL--RKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILED 461
S SL R ++ + KV + S + +M + Q + A +R + + R + +
Sbjct: 851 SSSLGSRTLDPLWKVRR-------SQKLDMSARLELQSALEAEIRAKQLVQEELRKVKDA 903
Query: 462 --TLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKAR-----KFSEFLSL------ 508
TLE KL KD++ + + L +E +L+ + E+K R K +F
Sbjct: 904 NLTLESKL------KDSEAKNRELLEEME-ILKKKMEEKFRADTGLKLPDFQDSIFEYFN 956
Query: 509 RGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVALPSTP-- 566
L ++T R E +P+ PS+ S A+P R V LP+T
Sbjct: 957 TAPLAHDLTFRTSSASEQETQAPKPEASPSMSVAASEQQEDMARPPQRPSAVPLPTTQAL 1016
Query: 567 --AEPPPPTRQSHGSHGSSLTQVS 588
A P P Q SS TQ S
Sbjct: 1017 ALAGPKPKAHQFSIKSFSSPTQCS 1040
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 67.8 bits (164), Expect = 4e-11
Identities = 71/320 (22%), Positives = 147/320 (45%), Gaps = 23/320 (7%)
Query: 194 EGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAE----RQRQLQEAELIHQREIEAK 249
E K +Q ++ + L +L+ +L+AQ E R Q QE ++ Q E +
Sbjct: 240 ERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 299
Query: 250 KEFDKWKEQEWTKLYGEIDKLKK---LFWDEFKNVAKQNSTL---EEKLRALQSHSVMES 303
+E +K +EQE K+ + +K+++ + W++ + + +Q + EEK+R L+ +
Sbjct: 300 RE-EKIQEQE-EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 357
Query: 304 KLGSLRDEESEEWL------RQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQE 357
K+ ++ EE RQ +E + R++ +I++ E K + +E + EK QE
Sbjct: 358 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQE 417
Query: 358 ENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP 417
E Q Q+Q++ + + +I +++EQ I QEEM+Q + E K+
Sbjct: 418 EKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKM- 476
Query: 418 KAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAK 477
E+++ +E E+ Q + + + + E+ ++E+ E M +++
Sbjct: 477 ----CEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Query: 478 GISIQTLRHLESLLRVQREQ 497
+ ++ E +R Q E+
Sbjct: 533 CEQEEKMQEQEEKMRRQEEK 552
Score = 65.5 bits (158), Expect = 2e-10
Identities = 60/263 (22%), Positives = 128/263 (48%), Gaps = 29/263 (11%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWK 256
K ++QE+ + E E++R + + + E RE E + + E E I ++E E ++E +K +
Sbjct: 317 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK--MHEQEKIREQE-EKRQEEEKIR 373
Query: 257 EQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEW 316
EQE + + + W + + + +Q + E+ +Q E K+G E+ E+
Sbjct: 374 EQE------KRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ---EEKMG----EQEEKM 420
Query: 317 LRQARELQALREKTEIQKT---EWKRKVKELHEEHMAEKKELQEENQRL---------QA 364
Q E+Q EK Q+ E ++K++E E+ +++ +QE+ +++ Q
Sbjct: 421 WEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQE 480
Query: 365 SLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEE 424
+ Q+Q++ + + +I +++EQ I QEEM+Q + E K+ + + +
Sbjct: 481 AKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 540
Query: 425 DSPEEEMEDSQDEQHKVLAALRR 447
+ EE+M +++ + LR+
Sbjct: 541 EQ-EEKMRRQEEKMREQEVRLRQ 562
Score = 55.8 bits (133), Expect = 1e-07
Identities = 91/402 (22%), Positives = 169/402 (42%), Gaps = 50/402 (12%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWK 256
+QK Q E + EL A+++ T L Q+ + + Q E EA+ +
Sbjct: 98 EQKASHQHQEALRRELEAQVQ-TIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 156
Query: 257 EQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEW 316
+ W K GE+++ + K + L ++ AL +E ++ DEE +E
Sbjct: 157 DS-W-KFAGELEQALSAVATQKKKADRYIEELTKERDALS----LELYRNTITDEELKEK 210
Query: 317 LRQARELQAL--REKTEIQKT--EWKRKV---------KELHEEHMAEKKELQEENQRLQ 363
+ +E L EK+EIQ E KRK+ ++L E KELQ + +LQ
Sbjct: 211 NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQ 270
Query: 364 AS---------LSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMI---------QSL 405
A L+Q Q++ + + +I ++QEQ I QEE + +
Sbjct: 271 AQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEE 330
Query: 406 SLRKVEGI--HKVPKAVDTEEDSPEE----EMEDSQDEQHKVLAALRRNPTLLKHFRP-- 457
+R+ E + K K + EE E+ E E+ + E+ K+ +R K +R
Sbjct: 331 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 390
Query: 458 ---ILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVK 514
E+ + E+ E M +++ G + + E ++ ++E+K R+ E + + K ++
Sbjct: 391 KIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQ-EQEEKMRRQEEKIREQEKKIR 449
Query: 515 EVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTR 556
E + +E++E + G+ K + +E + K R
Sbjct: 450 EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMR 491
Score = 55.1 bits (131), Expect = 2e-07
Identities = 54/300 (18%), Positives = 136/300 (45%), Gaps = 32/300 (10%)
Query: 108 VAQLEARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLL--MQTGTHSY 165
+ + E ++Q + + ++++ RQ + + E+ RR+ +M+ ++ + ++ H
Sbjct: 297 IQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ 356
Query: 166 HTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEA 225
++ +R +R+ + K +QE+ + E E++R + + Q + E
Sbjct: 357 EKIREQEEKRQEEEKIREQEKRQE----QEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 226 QREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQN 285
E E + QE E+ Q E + +++ +K +EQE K + +Q
Sbjct: 413 MGEQEEKMWEQEEEMQEQEE-KMRRQEEKIREQE-------------------KKIREQE 452
Query: 286 STLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELH 345
+ E+ +Q E K+G + E+ + + + +R + E + E ++K++E
Sbjct: 453 EKIREQEEMMQEQ---EEKMGEQEGKMCEQEAKMQEQEEKMRRQEE-KIREQEKKIREQE 508
Query: 346 EEHMAEKKELQEENQRL--QASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQ 403
E+ +++ +QE+ +++ Q +Q++ + + ++ +++EQ + QEE +Q
Sbjct: 509 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/335 (22%), Positives = 153/335 (45%), Gaps = 45/335 (13%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWK 256
K ++QE+ + E E++R +L+ E E RE E +RQ E E I ++E ++E W+
Sbjct: 425 KMRRQEEMMWEKEEKIR-ELEEKMHEQEKIREQEEKRQ--EEEKIREQEKRQEQEAKMWR 481
Query: 257 EQEWTKLYGE-IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEE 315
++E + E I + ++ W + + + +Q EE+ R E+ E
Sbjct: 482 QEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKR----------------QEQEEM 525
Query: 316 WLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKE----LQEENQRLQASLSQDQK 371
W R+ + +RE+ EI W++K K +E K+E QEE Q ++Q+
Sbjct: 526 W----RQEEKIREQEEI----WRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQE 577
Query: 372 KAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEM 431
+ + + +I +++EQ I QEEM Q + E K+ + EE+M
Sbjct: 578 EKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE--------QEEKM 629
Query: 432 EDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLL 491
++ +++ + +R ++ E+ + E+ E M +++ + + E +
Sbjct: 630 QEQEEKMRRQEEKIREQEKKIRE----QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 685
Query: 492 RVQREQKARKFSEFLSLRGKLVKEVTSRAKERQEN 526
+ ++E+K R+ E + + +++ + +E QE+
Sbjct: 686 Q-EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 719
Score = 67.4 bits (163), Expect = 5e-11
Identities = 73/341 (21%), Positives = 156/341 (45%), Gaps = 15/341 (4%)
Query: 124 RGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRG 183
R Q+E R+ +E+ +EE RR++ + ++ M+ + +
Sbjct: 392 REQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 451
Query: 184 HIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER----QRQLQEAE 239
I+ + E K ++QE+ E+ + R + K + E + + + E+ + ++ E E
Sbjct: 452 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQE 511
Query: 240 LIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHS 299
I + E ++E + W+++E + EI + K+ ++ + + KQ EEK+ +
Sbjct: 512 KIREEEKRQEQE-EMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ----EEKM--WRQEE 564
Query: 300 VMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEEN 359
M + +R++E + W RQ +++ EK I++ E K + +E + EK QEE
Sbjct: 565 KMHDQEEKIREQEEKVW-RQEEKIREQEEK--IREQEEKIREQEEMTQEQEEKMGEQEEK 621
Query: 360 QRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKA 419
Q Q+Q++ + + +I +++EQ I QEEM+Q + E K+ +
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQ 681
Query: 420 VDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILE 460
+ ++ EE+M +++ + LR+ ++ + LE
Sbjct: 682 EEKMQEQ-EEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 59.3 bits (142), Expect = 1e-08
Identities = 81/370 (21%), Positives = 167/370 (45%), Gaps = 54/370 (14%)
Query: 183 GHIQRRHAGVAEGGKQKKQEQPVEEVLEELRA-KLKWTQGELEAQREAERQRQLQEA-EL 240
G +++ + VA ++KK ++ +EE+ +E A L+ + + + E+ +LQE +L
Sbjct: 236 GELEQALSAVAT--QKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQL 293
Query: 241 IHQREIEAKKEFDKWKEQ-EWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHS 299
+ + E + + K + E KL +L+ E ++ K+ ++ KL+A
Sbjct: 294 VESEKSEIQLNVKELKRKLERAKLLLPQQQLQA----EADHLGKELQSVSAKLQA----- 344
Query: 300 VMESKLGSLRDEESEEW--LRQARELQALREKTEIQKTEWKRKVKELHEE--HMAEKKEL 355
+ EE+E W L Q +E + R++ +IQ EW+ K++E E+ EK
Sbjct: 345 ---------QVEENELWNRLNQQQEEKMWRQEEKIQ--EWEEKIQEQEEKIREQEEKIRE 393
Query: 356 QEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHK 415
QEE R Q + ++++ + + + +++ Q ++ +EE I+ L E +H+
Sbjct: 394 QEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE----EKMHE 449
Query: 416 VPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKL-------- 467
K + EE EEE Q+++ + A + R ++ + + EEK+
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ-EEKMWRQEEKIH 508
Query: 468 ESMGIRKDAKGISIQTLRHLESLLRVQ------------REQKARKFSEFLSLRGKLVKE 515
E IR++ K + + E +R Q +E+K RK E + + + + +
Sbjct: 509 EQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHD 568
Query: 516 VTSRAKERQE 525
+ +E++E
Sbjct: 569 QEEKIREQEE 578
Score = 55.1 bits (131), Expect = 2e-07
Identities = 49/228 (21%), Positives = 110/228 (48%), Gaps = 24/228 (10%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEA----ELIHQREIEAKKEF 252
K +QE+ + E E++R + K + E E R+ E+ R+ +E E IH++E + +K+
Sbjct: 499 KMWRQEEKIHEQ-EKIREEEKRQEQE-EMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556
Query: 253 DK-WKEQEWTKLYGEIDKLKKL---FWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSL 308
+K W+++E K++ + +K+++ W + + + +Q + E+ ++ M +
Sbjct: 557 EKMWRQEE--KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEK 614
Query: 309 RDEESEEWLRQARELQALREKTEIQKT---EWKRKVKELHE---------EHMAEKKELQ 356
E+ E+ Q ++Q EK Q+ E ++K++E E + EK Q
Sbjct: 615 MGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Query: 357 EENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQS 404
EE Q Q+Q++ + + ++ +L++Q + +E +++
Sbjct: 675 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 67.8 bits (164), Expect = 4e-11
Identities = 104/481 (21%), Positives = 208/481 (43%), Gaps = 65/481 (13%)
Query: 112 EARLQTSLGQQQRGQQELGRQADELKGVREESRRR--RKMISTLQQLLMQTGTHSYHTCH 169
E R + L +Q R ++EL ++ ++L E RRR R+ ++ L Q
Sbjct: 1069 ETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE--------- 1119
Query: 170 LCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREA 229
LR ++R E +Q ++E+ V++ E+L + E E +R
Sbjct: 1120 -------EEQLLREEREKRRRQELE--RQYREEEEVQQEEEQL------LREEPEKRRRQ 1164
Query: 230 ERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKL-----KKLFWDEFK----- 279
E +RQ +E E + Q E + +E + + QE + Y E ++L K+ + DE +
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 280 ---NVAKQNSTLEEKL--RALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQK 334
K+N+ + K+ + ++ + + LRD +S++ L+ Q R++ E ++
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR-EQER 1283
Query: 335 TEWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARI 394
W+++ + EE E++E +E +R + SQ++K+ + + + + + QE R
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRK--SQEEKQLLREEREE----KRRRQETDRK 1337
Query: 395 IASQEEMIQSLS---LRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTL 451
+E+++Q LR+ E K EE+ +E E+ + L R
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKF-----REEELRHQEQGRKFLEEEQRLRRQERERKF 1392
Query: 452 LKHFRPILEDTLEEKL---ESMGIRKDAKGISIQ--TLRHLESLLRVQREQKARKFSE-- 504
LK + + E++L R++ + +S Q + E +V+R+++ RKF E
Sbjct: 1393 LKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEE 1452
Query: 505 --FLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQVAL 562
R + +E +ER+E + D + + QQ R+ + + + L+
Sbjct: 1453 QQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE 1512
Query: 563 P 563
P
Sbjct: 1513 P 1513
Score = 67.0 bits (162), Expect = 6e-11
Identities = 89/443 (20%), Positives = 192/443 (43%), Gaps = 28/443 (6%)
Query: 112 EARLQTSLGQQQRGQQELGRQADELKGVREESRR---RRKMISTLQQLLMQTGTHSYHTC 168
E +L+ +++R QQE R+ E + +EE R RR+ +Q L +
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQ 362
Query: 169 HLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQRE 228
L R + R +Q ++EQ + + R + + +L +++
Sbjct: 363 QL----------RREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 229 AERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTL 288
R++QL+ + + + + E + E +E+ +L E ++ + E + +
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERR 472
Query: 289 EEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE--LHE 346
+++L+ Q E L L +EE E ++ RE Q RE+ E ++ KR+ +E L +
Sbjct: 473 KQQLKRDQEEERRERWL-KLEEEERRE-QQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 347 EHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLS 406
+E++ +E+ +R + L ++++K Q + + R Q + + +++ +EE Q
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 407 LRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEK 466
R+ E E+ EE+E + E+ + R P + + +L+ +E+
Sbjct: 591 KREQE--------ERLEQRLKREEVERLEQEERREQRLKREEPEEERR-QQLLKSEEQEE 641
Query: 467 LESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQEN 526
+R++ + Q L+ E R+ EQ+ ++ E +L +E +A+ER ++
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERL--EQRLKREHEEERREQELAEEEQEQARERIKS 699
Query: 527 GAAVSQPDGQPSVKSQQSALVTR 549
Q + ++QS + +R
Sbjct: 700 RIPKWQWQLESEADARQSKVYSR 722
Score = 65.9 bits (159), Expect = 1e-10
Identities = 95/446 (21%), Positives = 192/446 (43%), Gaps = 58/446 (13%)
Query: 110 QLEARLQTS----LGQQQRGQQELGRQADE-------LKGVREESRRRRKMISTLQQLLM 158
+LE RL+ L Q++R +Q L R+ E LK +E RR++++ Q+
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 159 QTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKW 218
Q K L ++R H E +Q+ E+ E+ E +++++
Sbjct: 657 QRL-----------KREEEEERLEQRLKREHE--EERREQELAEEEQEQARERIKSRIPK 703
Query: 219 TQGELEAQREAERQR-----QLQEAELIHQREIEAKKEFD---KWKEQEWTKLYGEIDKL 270
Q +LE++ +A + + + QE + Q + E ++ + +W+E+E + ++
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 271 KKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKT 330
++ F +++ K + R + E + LR EE RQ RE + L E+
Sbjct: 764 RRDFTWQWQAEEKSE---RGRQRLSARPPLREQRERQLRAEE-----RQQREQRFLPEEE 815
Query: 331 EIQKTEWKRKVKE-----LHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLR 385
E ++ +R+ +E L EE +++E ++ Q + L +DQ++ +Q Q + R
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 386 AQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAAL 445
QL+E+ + + + +L+ E + K + + EE+ + E + + Q +
Sbjct: 876 WQLEEERK--RRRHTLYAKPALQ--EQLRKEQQLLQEEEEELQREEREKRRRQEQE-RQY 930
Query: 446 RRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHL------ESLLRVQREQKA 499
R L + +L + E++ R+ K +Q E R +RE+K
Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 500 RKFSEFLSLRGKLVKEVTSRAKERQE 525
R+ E +L++E R K R++
Sbjct: 991 REEEELQQEEEQLLRE--EREKRRRQ 1014
Score = 64.3 bits (155), Expect = 4e-10
Identities = 78/375 (20%), Positives = 163/375 (43%), Gaps = 47/375 (12%)
Query: 186 QRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER-------------- 231
Q + +AEG +Q ++++ +E+ + R + W Q + +RE R
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 232 -----QRQLQEAELIH-----------QREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFW 275
+ QL+ EL+ QR + F + +E+EW K + K ++
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 276 DEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKT 335
+E ++ EE+LR L+ +L R EE ++ R RE Q LR K E ++
Sbjct: 262 EEEPQRQRELQEEEEQLRKLE-----RQELRRERQEEEQQQQRLRRE-QQLRRKQEEERR 315
Query: 336 EWKRKVKELHEEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQAR-- 393
E + + +E E +++ +++ +R Q + Q + + + + LR + +E+ R
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 394 IIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLK 453
+ ++++ + LR+ + + + + E E + +++Q + LRR +
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQL--RREQQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 454 HFRPILEDTLEEKLE-SMGIRKDAKGISIQTLRHLESLLRVQ--REQKARKFSEFLSLRG 510
H + ++ E++L+ R+D +T RH + + Q R+Q+ + +L
Sbjct: 434 HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL---- 489
Query: 511 KLVKEVTSRAKERQE 525
KL +E +ER+E
Sbjct: 490 KLEEEERREQQERRE 504
Score = 64.3 bits (155), Expect = 4e-10
Identities = 102/453 (22%), Positives = 182/453 (40%), Gaps = 82/453 (18%)
Query: 126 QQELGRQADELKGVREESR---RRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLR 182
+Q++ RQ E K + EE + R + +QLL + H + + FL
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH------RQERDRKFLE 1489
Query: 183 GHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIH 242
Q R +Q++ + E+ L + K+ + E + R+ +++ LQE + +
Sbjct: 1490 EEQQLR--------RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 243 QREIEAKKEFD---KWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHS 299
++E ++ D K++E+E + E +L + D + +Q +E Q
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE-----QERK 1596
Query: 300 VMESKLGSLRDEESEEWLRQAREL------QALREKTEIQKTEWKRKVKELHEEHMAEKK 353
ME + LR +E ++ LRQ R+ Q L+E+ E Q +R K L EE ++
Sbjct: 1597 FMEDEQ-QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 354 E------------LQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEM 401
E +EE Q LQ Q ++ + + + + QE+ R +E+
Sbjct: 1656 EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 402 IQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPIL-E 460
++ L E EEE + EQ + LRR + +R IL E
Sbjct: 1716 LRRQEL---------------ERKFREEEQLRQETEQEQ----LRRQ----ERYRKILEE 1752
Query: 461 DTLEEKLESMGIR---KDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVT 517
+ L + E +R +D K + LR +++ ++ RKF E LR
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR-------- 1804
Query: 518 SRAKERQENGAAVSQPDGQPSVKSQQSALVTRE 550
+ER+E Q DG+ + +Q L +E
Sbjct: 1805 ---QEREEQQLRPQQRDGKYRWEEEQLQLEEQE 1834
Score = 62.8 bits (151), Expect = 1e-09
Identities = 93/426 (21%), Positives = 181/426 (42%), Gaps = 73/426 (17%)
Query: 112 EARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLC 171
E +LQ QQ ++E G Q D+ + +E RR +K L++
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEE---------------- 880
Query: 172 DKTFMNATFLRGHIQRRHAGVAEGGKQ---KKQEQPVEEVLEELRAKLKWTQGELEAQRE 228
+RRH A+ Q +K++Q ++E EEL+ + E E +R
Sbjct: 881 -----------ERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE------EREKRRR 923
Query: 229 AERQRQLQEAELIHQREIEA-KKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNST 287
E++RQ +E E + Q E + ++E +K + QE + Y + KL++ K+
Sbjct: 924 QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ----------KEEQL 973
Query: 288 LEEKLRALQSHSVMESKLGSLRDEE--SEEWLRQARELQALREKTEIQKTEWKRKVKELH 345
L E+ E + R+++ EE L+Q E E+ + ++ EW+R+ ++
Sbjct: 974 LGEE---------PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKD 1024
Query: 346 EEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQ------LQEQARIIASQE 399
E E++ L+EE ++ + + Q + + Q + L + QE R +E
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 400 EMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPIL 459
E+ Q E K + + EEE++ +++ + RR L + +R
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE-- 1142
Query: 460 EDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSR 519
E+ ++++ E + +R++ + R + L R RE++ + E LR + K R
Sbjct: 1143 EEEVQQEEEQL-LREEPE------KRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195
Query: 520 AKERQE 525
++ +E
Sbjct: 1196 ERQYRE 1201
Score = 62.0 bits (149), Expect = 2e-09
Identities = 95/462 (20%), Positives = 200/462 (43%), Gaps = 57/462 (12%)
Query: 120 GQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNAT 179
G++++ QQ RQ + E+ R+R+ + ++ +Q L ++
Sbjct: 222 GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE-EEPQRQRELQEEEEQLRK 280
Query: 180 FLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAE 239
R ++R + ++ ++EQ + EE R + + + E + +RE + +R+ Q+
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQL- 339
Query: 240 LIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHS 299
+RE E ++E +EQE E + ++L ++ + +Q E++LR Q
Sbjct: 340 ---RREQEERREQQLRREQE------EERREQQLRREQEEERREQQLRREQQLRREQ--- 387
Query: 300 VMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKELQEEN 359
LR E+ +Q R Q LR + ++++ + R+ ++L E E+ E + E
Sbjct: 388 -------QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 360 QRLQASLSQDQKKAAAQSQCQISTLR-AQLQEQARIIASQEEMIQSLSLR-----KVEGI 413
+R + L ++Q++ + + T R Q + + ++ QEE + L+ + E
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Query: 414 HKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALR-----------RNPTLLKHFRPILEDT 462
+ + + E++ E+ Q+E+ ++ LR R LLK E
Sbjct: 501 ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE---EKR 557
Query: 463 LEEKLESMGIRKDAKGISIQTLRHLES--LLRVQREQKARKFSEFLSLRGKLVKEVTSR- 519
LE++ ++++ + Q L+ E R++REQ+ R L +L +E R
Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER-------LEQRLKREEVERL 610
Query: 520 -AKERQENGAAVSQPDGQPSVKSQQSALVTREAQPKTRTLQV 560
+ER+E +P+ + ++ L+ E Q + R Q+
Sbjct: 611 EQEERREQRLKREEPE-----EERRQQLLKSEEQEERRQQQL 647
Score = 61.6 bits (148), Expect = 3e-09
Identities = 76/349 (21%), Positives = 160/349 (45%), Gaps = 53/349 (15%)
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWK 256
+ +++ +P + LEE + + + + + + AE + Q ++ E + QR+ + + E + W+
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDE-ELWR 175
Query: 257 E-QEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVME---------SKLG 306
+ QEW + ++ EE+L++ + H E +L
Sbjct: 176 QRQEWQE-------------------REERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 307 SLRDEESEEWLRQARELQALREKTEIQKTEWKRK-------VKELHEEHMAEKKELQEEN 359
LR + EE +Q RE Q R E ++ EW+++ ++L EE ++ELQEE
Sbjct: 217 ELRRKGREEKQQQRRERQD-RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 360 QRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKA 419
++L+ Q+ ++ + + Q LR + Q + + +EE + R+ + +
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRK---QEEERREQQEERREQQERR---- 328
Query: 420 VDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGI 479
+ +E+ E+++ Q+E+ + LRR + + + + EE+ E +R++ +
Sbjct: 329 -EQQEERREQQLRREQEERRE--QQLRREQEEERREQQLRREQEEERREQQ-LRREQQLR 384
Query: 480 SIQTLRHLESLLRVQ---REQKARKFSEFLSLRGKLVKEVTSRAKERQE 525
Q LR + L R Q REQ+ R+ + L +L +E R ++ +E
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRR-EQQLRREQQLRREQQLRREQEEE 432
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/422 (21%), Positives = 184/422 (43%), Gaps = 51/422 (12%)
Query: 112 EARLQTSLGQQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLC 171
E R + ++ R ++EL ++ ++L +REE +RR+ Q Y
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQL--LREEREKRRR----------QEWERQYRKKDEL 1026
Query: 172 DKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAER 231
+ LR ++R + E +Q ++E+ +++ E+L + + T+ E +R+ +
Sbjct: 1027 QQE--EEQLLREEREKRR--LQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 232 QRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEK 291
+ +LQ+ E E ++E +K + QE + E ++L++ ++ ++ +E
Sbjct: 1083 EEELQQEE-----EQLLREEPEKRRRQERERQCREEEELQQ-EEEQLLREEREKRRRQEL 1136
Query: 292 LRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEEHMAE 351
R + ++ + L EE E+ RQ E Q RE+ E+Q+ E ++L E +
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQ-YREEEELQQEE-----EQLLREEQEK 1190
Query: 352 KKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVE 411
+++ +E R + L + ++K + + Q S L+ Q + + +E ++ KV
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPE------KENAVRD---NKVY 1241
Query: 412 GIHKVPKAVDTEEDSPEEEMEDSQDEQHKV--------LAALRRNPTLLKHFRPILEDTL 463
+ + EDS + + QD QH + RR +HF E+ L
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE--EEQL 1299
Query: 464 EEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKER 523
E + + R+D K + L E + +R++ RKF E +L++E + R
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE----EEQLLQEREEQPLRR 1355
Query: 524 QE 525
QE
Sbjct: 1356 QE 1357
Score = 57.8 bits (138), Expect = 4e-08
Identities = 77/331 (23%), Positives = 150/331 (45%), Gaps = 34/331 (10%)
Query: 121 QQQRGQQELGRQADELKGVREESRRR-----RKMISTLQQLLMQTGTHSYHTCHLCDKTF 175
+Q+R +Q+L RQ + K EE + R RK + QQL Q G D+ F
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER--DRKF 1621
Query: 176 MNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQRE---AERQ 232
L +Q R E + +QE+ + + EE + + + + +L R+ E +
Sbjct: 1622 REDEQL---LQER-----EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEE 1673
Query: 233 RQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKL 292
+ LQE E R E ++F + +EQ+ + + ++ F E + + +Q LE K
Sbjct: 1674 QLLQEGEEQQLRRQERDRKF-REEEQQLRR-----QERERKFLQEEQQLRRQE--LERKF 1725
Query: 293 RALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKE---LHEEHM 349
R + E++ LR +E + + +L+ RE+ ++++ E RK +E L +E
Sbjct: 1726 RE-EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE 1784
Query: 350 AEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRK 409
++ QE +++ + Q++ Q + Q + + +E+ + QE+ ++ R+
Sbjct: 1785 EQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQ 1844
Query: 410 VEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
++ + T+E S EE E Q+E+ K
Sbjct: 1845 ----YRAEEQFATQEKSRREEQELWQEEEQK 1871
Score = 55.8 bits (133), Expect = 1e-07
Identities = 78/369 (21%), Positives = 154/369 (41%), Gaps = 34/369 (9%)
Query: 197 KQKKQEQPVEEVLE-----ELRAKLKWTQGE---LEAQREAERQRQLQEAELIHQREIEA 248
+Q+ + P EE LE E + + + +Q E L +RE +R+RQ + + + ++
Sbjct: 1287 QQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 249 KKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEE--KLRALQSHSVMESKLG 306
++E + QE + + E +E ++ + LEE +LR + +
Sbjct: 1347 EREEQPLRRQERDRKFRE---------EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ 1397
Query: 307 SLRDEESEEWLRQARELQALREKTEIQKTEWKRKVKELHEE---HMAEKKELQEENQRLQ 363
LR +E E+ LRQ R+ + E+ ++ + E RK +E ++ E+K L+EE Q Q
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457
Query: 364 ASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTE 423
+ +K + Q QL Q R EE Q LR+ E K + +
Sbjct: 1458 ----ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ---LRRQERDRKF-REQELR 1509
Query: 424 EDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQT 483
PE + + + + H+ +R L+ + + ++ RK + ++
Sbjct: 1510 SQEPERKFLEEEQQLHR----QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 484 LRHLESLLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQ 543
R + L R +R++K R + + + + K + + R++ G + + + +
Sbjct: 1566 EREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE 1625
Query: 544 SALVTREAQ 552
L RE Q
Sbjct: 1626 QLLQEREEQ 1634
Score = 53.9 bits (128), Expect = 5e-07
Identities = 70/331 (21%), Positives = 143/331 (43%), Gaps = 50/331 (15%)
Query: 112 EARLQTSLGQQQRG------QQELGRQADELKGVREESRRRR------------KMISTL 153
+ R + L +Q+R +Q++ RQ E K + +E + RR +
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED 1624
Query: 154 QQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEE-L 212
+QLL + H K LR + + K +++EQ ++E E+ L
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 213 RAK---LKWTQGELEAQREAERQRQLQEAELIHQREIEAK-KEFDKWKEQEWTKLYGEID 268
R + K+ + E + +R+ ++ LQE + + ++E+E K +E ++ +++ + +
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 269 KLKKLFWDEFKNVAKQNSTL-----------EEKLRALQSHSVMESKLGSLRDEESEEWL 317
+ +K+ +E ++ L EE+LR + + S+ + E EE L
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFRE-EEQL 1803
Query: 318 RQARELQALREKTEIQKTEWKRKVKELHEEHMAEKKE------------LQEENQRLQAS 365
RQ RE Q LR + K W+ + +L E+ ++E QE+++R +
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQE 1863
Query: 366 LSQDQKKAAAQS---QCQISTLRAQLQEQAR 393
L Q++++ Q + + +R Q +E+ R
Sbjct: 1864 LWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Score = 52.4 bits (124), Expect = 2e-06
Identities = 89/418 (21%), Positives = 180/418 (43%), Gaps = 48/418 (11%)
Query: 111 LEARLQTSLGQQQRGQQELGRQADELKGVR----EESRRRRKMISTLQQLLMQTGTHSYH 166
L+ +T +Q+R +Q+L R +E + R EE RR + QQL +
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 167 TCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQ 226
++ LR Q R ++QE+ E++L+ K LE +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLR----------REQEERREQLLKREEEK------RLEQE 561
Query: 227 REAERQRQLQEA--ELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQ 284
R +R ++ QE + + +RE E +++ K +++E + + +++++L +E + +
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621
Query: 285 NSTLEEKLR--ALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWKRKVK 342
EE+ R L+S E + LR E+ E R Q L+ + E ++ E +++K
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQE------RREQRLKREEEEERLE--QRLK 673
Query: 343 ELHEEHMAEKKELQEE----NQRLQASLSQDQKKAAAQSQCQISTL--RAQLQEQARIIA 396
HEE E++ +EE +R+++ + + Q + +++ + S + R + QE R
Sbjct: 674 REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733
Query: 397 SQEEMIQ----SLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALR------ 446
QEE + L ++ E H+ + + D + + + E+ + + R
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 447 RNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSE 504
R L R E + E R+ + + L+ LE ++QR ++A++ E
Sbjct: 794 RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Score = 47.0 bits (110), Expect = 7e-05
Identities = 62/271 (22%), Positives = 121/271 (44%), Gaps = 61/271 (22%)
Query: 122 QQRGQQELGRQADELKGVREESR-----RRRKMISTLQQLLMQTGTHSYHTCHLCDKTFM 176
Q+ +Q+L RQ + K EE + R RK + QQL Q ++ F
Sbjct: 1677 QEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE----------LERKFR 1726
Query: 177 NATFLRGHIQRRHAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGELEAQREAERQRQLQ 236
LR ++ +Q ++++ ++LEE + + + + +L Q ER R+ +
Sbjct: 1727 EEEQLRQETEQ---------EQLRRQERYRKILEEEQLRPEREEQQLRRQ---ERDRKFR 1774
Query: 237 EAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQ 296
E E + Q ++E + + QE + + E ++L++ E++LR Q
Sbjct: 1775 EEEQLRQ-----EREEQQLRSQESDRKFREEEQLRQ-------------EREEQQLRPQQ 1816
Query: 297 SHSVMESKLGSLRDEESEEWLRQARELQ------------ALREKTEI-QKTEWKRKV-- 341
+ L+ EE E+ LRQ R+ Q + RE+ E+ Q+ E KR+
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Query: 342 -KELHEEHMAEKKELQEENQRLQASLSQDQK 371
++L EEH+ +++ ++ ++++ SQ+ K
Sbjct: 1877 ERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 67.4 bits (163), Expect = 5e-11
Identities = 118/518 (22%), Positives = 224/518 (43%), Gaps = 87/518 (16%)
Query: 108 VAQLEARLQTSLGQ---QQRGQQELGRQ-------ADELKGVREESRRRRKMISTL---- 153
VAQL R Q L Q +QR ++LGRQ AD L +++RRR++ I +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 154 -----------QQLLMQTGTH--SYHTCHLCDKTFMNA----TFLRGHIQRRHAGVAEGG 196
Q LL + H C K ++NA + + VA
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGEL------------EAQREAERQRQLQEAELIHQR 244
K+ K + E V++E L+ EL E R E + +L E + +R
Sbjct: 1301 KKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 245 EIEAKKEFDKWKEQEWTKLYG--------EIDKLKKLFWDEF-------KNVAKQNSTLE 289
E A+ E K+++ + + E +L++ +E + +Q +++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 290 EKLRALQSHSVMESKLGSLRDEESE-EWLRQARELQALR---EKTEIQKTEWKRKVKELH 345
E+L+ L+ S E + + + E +E LR E++ +R E TE Q+ + +++ L
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 346 ---EEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQI-STLRAQ----------LQEQ 391
EE A+K++ QEE +RL+ + QD+ + Q++ ++ S ++A+ LQ
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQV-QDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 392 ARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQ----DEQHKVLAALRR 447
+ EE + L +VE +V A++T + S E E++ + ++ ++ +L+
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 448 NPTLLKHFRPILEDTLEEKLESMGIRKDA-KGISIQTLRHLESL-LRVQREQKARKFSEF 505
+ R E +++ E+ R++A + + L+ E+L LR+Q E+ A++ S
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-- 1656
Query: 506 LSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQ 543
+ + K+ +E + G A Q Q + Q+
Sbjct: 1657 -LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Score = 62.4 bits (150), Expect = 2e-09
Identities = 112/531 (21%), Positives = 213/531 (40%), Gaps = 93/531 (17%)
Query: 70 EVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSA-SVAQLEARLQTSLGQQQRGQQE 128
E R + + + L+LAQ + L ++ A +V Q E LQ +L Q+Q
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS---- 2074
Query: 129 LGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRR 188
D+L+G E +RR + + + S RR
Sbjct: 2075 ---VLDQLRGEAEAARRAAEEAEEARVQAEREAAQS----------------------RR 2109
Query: 189 HAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGEL--EAQREAERQRQLQEAELIHQREI 246
AE KQ +EQ + RA+ + +L EA++EA R+ Q ++A L ++
Sbjct: 2110 QVEEAERLKQSAEEQA------QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 247 EAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLG 306
+A+ E K ++ + ++++ + + Q + L+E+L+ L++ + ++
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 307 SLRDEESEEWLRQARELQALREKTEIQK---------------TEWKRKVKELHEE---- 347
S +EE Q EL L+ + E + E K+K++ EE
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 348 -----HMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQ----------LQEQA 392
A ++L EE+ Q +L++ K Q+ + + L+A+ QEQA
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 393 RIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
R + +E + + +G + +A + E E + ++ A R
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTL------------RHLESLLRVQRE-QKA 499
+ FR E+ + EKL + K +QTL R E++ ++RE +K
Sbjct: 2404 QRFRKQAEE-IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 500 RKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTRE 550
++ ++ L L+ + ++ V + + QE A Q S S++ +L+ RE
Sbjct: 2463 QQEAKLLQLKSEEMQTV-QQEQLLQETQAL------QQSFLSEKDSLLQRE 2506
Score = 60.1 bits (144), Expect = 8e-09
Identities = 105/477 (22%), Positives = 204/477 (42%), Gaps = 70/477 (14%)
Query: 88 RLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQ-QQRGQQELGRQADELKGVREESRRR 146
RLA+ +E L Q L+ + AQ +A+ + + QQR Q+E+ R+ + +++ R
Sbjct: 1361 RLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 147 RKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ--P 204
++ + L+Q ++ + R A AE + + +E+
Sbjct: 1419 QEELQQLRQ----------------------SSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 205 VEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLY 264
V LE + +GEL+A R + + Q+ Q + EA++ + +++ K
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQK----RQAQEEAERLRRQVQDESQRKRQ 1512
Query: 265 GEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQ 324
E++ + V + EK RALQ+ + L+ EE+E LRQA E++
Sbjct: 1513 AEVELASR--------VKAEAEAAREKQRALQALEELR-----LQAEEAERRLRQA-EVE 1558
Query: 325 ALREKTEIQKTEWKRKVKELHEEH--MAEK-KELQEENQRLQASLSQDQKKAAAQSQCQI 381
R+ +T + EL + AEK +L+ Q +++Q +++A ++Q Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 382 STLRAQLQEQARIIASQEEMIQSLSLR-KVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
RA+ + + + Q + ++L LR + E + + E + +EE E + K
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRV-----QR 495
R R + E LE++ R+ A+G + Q L + L+R+ Q
Sbjct: 1679 AEEQAVRQ-------RELAEQELEKQ------RQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 496 EQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
EQ+ + E L+ +L +E + ++RQE A +++ + V A E++
Sbjct: 1726 EQQRQLLEEELA---RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Score = 56.2 bits (134), Expect = 1e-07
Identities = 106/498 (21%), Positives = 213/498 (42%), Gaps = 79/498 (15%)
Query: 101 QDCLSASVAQLEARLQTSLGQQQRG--QQELGRQADELKGVREESRRRR----KMISTLQ 154
Q L+A + R +T G+QQR ++EL R E ++ + K+ + ++
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 155 QLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQR------RHAGVAEGGKQKKQ------- 201
LL + +K+ G + R +AE K+++Q
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 202 --EQPVEEVLEELRA------KLKWTQGEL---EAQREAERQRQLQEAELIHQREIEA-- 248
E VL E A +LK T+ E+ E + E ER R+L E E +R +E
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 249 ---KKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSH------- 298
K + ++ Q E+++ K L D + Q +EE++ AL++
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLR----QRRQVEEEILALKASFEKAAAG 1940
Query: 299 -SVMESKLGSLRDEESEEWLR--QARELQALREKTEIQKTEWKRKVKE--------LHEE 347
+ +E +LG +R +E+ LR + EL+A R++ + E +R+ E EE
Sbjct: 1941 KAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 348 HMAEKKELQEENQRLQASLSQ-------DQKKAAAQSQC--QISTLRAQLQEQARIIA-S 397
++K EE +RL+A + + ++++A Q Q + + R Q +E+A A
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 398 QEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRP 457
Q+E +L++ + + + EE E+++ + + A RR + +
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 458 ILEDTLEEKLESMG----IRKDAKGISIQTLRHLESLLRVQRE-----QKARKFSE-FLS 507
E+ + + ++ +RK+A+ + + + ++ LR ++ +K +KF+E L
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 508 LRGKLVKEVTSRAKERQE 525
+ ++ +E+T+ + +E
Sbjct: 2180 QKAQVEQELTTLRLQLEE 2197
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/384 (22%), Positives = 170/384 (44%), Gaps = 60/384 (15%)
Query: 108 VAQLEARLQTS-----LGQQQRGQQELGRQADELKGVREESRR---RRKMISTLQQLLMQ 159
+++L+AR++ L + Q+ L +A+++K V EE+ R + + L+QL +
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 160 TGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQP--VEEVLEELRAKLK 217
K M A + + A + + K+ QEQ ++E E++ +L
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 218 WTQGELEAQREAERQRQLQ---EAELIHQREIEAKK----------EFDKWKEQEWTKLY 264
+ EAERQRQL+ EAE + R E + F K E+ KL+
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418
Query: 265 G-EIDKLKKLFWDEFKNVAKQNSTLE-EKLRALQSHSVMESKLGSLRDEESEEWLRQARE 322
E+ +K+ + + +Q S + E+LR ++ + +E + L+ E L+ + E
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLR--EAIAELEREKEKLQQEAKLLQLK-SEE 2475
Query: 323 LQALREKTEIQKT----------------------EWKRKVKELHEEHMAEKKELQEENQ 360
+Q ++++ +Q+T + K K+++L ++ +A+ ++L+EE Q
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
R Q + Q++++ A + R Q + + + QEE L+++E + + +
Sbjct: 2536 RQQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEE------LQQLEQQRRQQEEL 2586
Query: 421 DTEEDSPEEEMEDSQDEQHKVLAA 444
EE+ E +EQH+ A
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALA 2610
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/302 (23%), Positives = 137/302 (45%), Gaps = 34/302 (11%)
Query: 89 LAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELK-GVREESRRRR 147
LAQ L ++ ++ +A+ Q +L +++ Q E+ +A+ LK V E SR +
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397
Query: 148 KMISTLQQLLMQTGT--HSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPV 205
+ Q+ Q H L T T ++ +R + + ++ +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELA--TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455
Query: 206 EEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEF---DKWKEQEWTK 262
E E+L+ + K Q + E + ++++ LQE + + Q + K +++ EQE K
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 263 LYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDE------ESEEW 316
L ++LF DE VAK EE+ R Q +L + +E E+EE
Sbjct: 2516 L-------EQLFQDE---VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 317 LRQARELQALREKTEIQKTEWKRKVKE--LHEEHMAEKKELQEENQRLQASLSQDQKKAA 374
+R+ +E E+Q+ E +R+ +E L EE+ +++LQ ++ +A+L+ ++ A
Sbjct: 2566 VRRKQE--------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 375 AQ 376
+Q
Sbjct: 2618 SQ 2619
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/511 (21%), Positives = 207/511 (40%), Gaps = 75/511 (14%)
Query: 109 AQLEARLQT--SLGQQQRGQQELGRQADELKGVRE-ESRRRRKMISTL----QQLLMQTG 161
AQ EA+ T +L + RG QE+G + + G R+ E R R+ ++ L Q +L QT
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196
Query: 162 THSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEV-LEELRAKLKWTQ 220
++ + R A + + ++++Q Q + + +R +L+ Q
Sbjct: 1197 VRQREL----EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252
Query: 221 GELEAQREAERQ-RQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK 279
LE E ER +++E + ++ I A K+++ +L KK
Sbjct: 1253 ALLE---EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK------P 1303
Query: 280 NVAKQNSTLEEKLRALQSHSVMESKLGS---------LRDEESEEWLRQARELQALREKT 330
V + ++ ++ L++H + L S LR E EE L + + +
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1363
Query: 331 EIQKT-EWKRKVKELHEEHMA----EKKELQEENQ-----RLQASLSQDQKKAAAQSQCQ 380
E++ E +R++ E H + A E KELQ+ Q R +A++ Q+K + Q + Q
Sbjct: 1364 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP---KAVDTEEDSPEEEMEDSQDE 437
LR + + + A Q E + LR E I V +A + + E E++ +
Sbjct: 1424 --QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 438 QHKVLAALRRNPTLLKHFRPILEDTLEEKLES---MGIRKDAKG-ISIQTLRHLESL--L 491
+ A R+ + R ++D + K ++ + R A+ + + R L++L L
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 492 RVQREQKARKF-----------------------SEFLSLRGKLVKEVTSRAKERQENGA 528
R+Q E+ R+ +E S R ++ + QE
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1601
Query: 529 AVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
AV+Q + ++QQ A R + R L+
Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/464 (20%), Positives = 178/464 (38%), Gaps = 51/464 (10%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
++QR Q L +EL+ EE+ RR + + +Q + + A+F
Sbjct: 1530 EKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 181 ------LRGHIQRRHAGVA----EGGKQKKQEQPVEEVLEELRAKL-KWTQGELEAQR-- 227
L +Q H VA E ++ +Q+ E EE +L +W EA R
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 228 ----EAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEI-----DKLKKLFWDEF 278
E +Q+ L +AE Q+E ++ + K +E E+ +K ++L
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA---- 1701
Query: 279 KNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ A+Q E++L L++ + + L +EE R+A R++ E +
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA--- 1758
Query: 339 RKVKELHEEHMAEKKELQEEN--------QRLQASLSQDQKKA--AAQSQCQISTLRAQL 388
KV+ E +A K +EE+ QRL+A + ++ A AA+ + + Q
Sbjct: 1759 -KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 389 QEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRN 448
Q A Q + + K+ I + + + TE + +E E + ++
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 449 PTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSL 508
L+ + +EE+L + D++ L + L+ Q+ + E L+L
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSE------LERQKGLVEDTLRQRRQVEEEILAL 1930
Query: 509 RGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
+ K +A+ E G S + K Q R+ Q
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Score = 43.1 bits (100), Expect = 0.001
Identities = 79/397 (19%), Positives = 147/397 (37%), Gaps = 53/397 (13%)
Query: 207 EVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGE 266
E L+ + ++ TQG E R E Q + +A E+EA K K KL +
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-------KLRAQ 1138
Query: 267 IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQAREL--- 323
+ + F L ++LR Q + RD E E W + +L
Sbjct: 1139 AEAQQPTF-----------DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 324 -QALREKTEIQKTEWKRKVKELHEEH---------MAEKKELQEENQRLQASLSQDQKKA 373
QA+ +T++++ E ++ ++L + + + QE+ Q + + SQ ++
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 374 AAQSQCQISTLR---AQLQEQARIIASQEEMIQSLSLRKVEGIHKV-PKAVDTEEDSPEE 429
Q Q + + +++E R I+ L+ V ++ P A ++ +
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 430 EMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLES 489
E E + TL + + +TL E + + + + L +E+
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367
Query: 490 LLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTR 549
L QR+ + E ++AK + E A Q Q V ++ A V
Sbjct: 1368 ALEKQRQ----------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411
Query: 550 EAQPKT--RTLQVALPSTPAEPPPPTRQSHGSHGSSL 584
+ Q ++ LQ S+ AE RQ+ + S L
Sbjct: 1412 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 67.4 bits (163), Expect = 5e-11
Identities = 118/518 (22%), Positives = 224/518 (43%), Gaps = 87/518 (16%)
Query: 108 VAQLEARLQTSLGQ---QQRGQQELGRQ-------ADELKGVREESRRRRKMISTL---- 153
VAQL R Q L Q +QR ++LGRQ AD L +++RRR++ I +
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244
Query: 154 -----------QQLLMQTGTH--SYHTCHLCDKTFMNA----TFLRGHIQRRHAGVAEGG 196
Q LL + H C K ++NA + + VA
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1304
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGEL------------EAQREAERQRQLQEAELIHQR 244
K+ K + E V++E L+ EL E R E + +L E + +R
Sbjct: 1305 KKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1363
Query: 245 EIEAKKEFDKWKEQEWTKLYG--------EIDKLKKLFWDEF-------KNVAKQNSTLE 289
E A+ E K+++ + + E +L++ +E + +Q +++
Sbjct: 1364 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 290 EKLRALQSHSVMESKLGSLRDEESE-EWLRQARELQALR---EKTEIQKTEWKRKVKELH 345
E+L+ L+ S E + + + E +E LR E++ +R E TE Q+ + +++ L
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 346 ---EEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQI-STLRAQ----------LQEQ 391
EE A+K++ QEE +RL+ + QD+ + Q++ ++ S ++A+ LQ
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQV-QDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1542
Query: 392 ARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQ----DEQHKVLAALRR 447
+ EE + L +VE +V A++T + S E E++ + ++ ++ +L+
Sbjct: 1543 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602
Query: 448 NPTLLKHFRPILEDTLEEKLESMGIRKDA-KGISIQTLRHLESL-LRVQREQKARKFSEF 505
+ R E +++ E+ R++A + + L+ E+L LR+Q E+ A++ S
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-- 1660
Query: 506 LSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQ 543
+ + K+ +E + G A Q Q + Q+
Sbjct: 1661 -LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Score = 62.4 bits (150), Expect = 2e-09
Identities = 112/531 (21%), Positives = 213/531 (40%), Gaps = 93/531 (17%)
Query: 70 EVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSA-SVAQLEARLQTSLGQQQRGQQE 128
E R + + + L+LAQ + L ++ A +V Q E LQ +L Q+Q
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS---- 2078
Query: 129 LGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRR 188
D+L+G E +RR + + + S RR
Sbjct: 2079 ---VLDQLRGEAEAARRAAEEAEEARVQAEREAAQS----------------------RR 2113
Query: 189 HAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGEL--EAQREAERQRQLQEAELIHQREI 246
AE KQ +EQ + RA+ + +L EA++EA R+ Q ++A L ++
Sbjct: 2114 QVEEAERLKQSAEEQA------QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 247 EAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLG 306
+A+ E K ++ + ++++ + + Q + L+E+L+ L++ + ++
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Query: 307 SLRDEESEEWLRQARELQALREKTEIQK---------------TEWKRKVKELHEE---- 347
S +EE Q EL L+ + E + E K+K++ EE
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287
Query: 348 -----HMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQ----------LQEQA 392
A ++L EE+ Q +L++ K Q+ + + L+A+ QEQA
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347
Query: 393 RIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
R + +E + + +G + +A + E E + ++ A R
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTL------------RHLESLLRVQRE-QKA 499
+ FR E+ + EKL + K +QTL R E++ ++RE +K
Sbjct: 2408 QRFRKQAEE-IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2466
Query: 500 RKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTRE 550
++ ++ L L+ + ++ V + + QE A Q S S++ +L+ RE
Sbjct: 2467 QQEAKLLQLKSEEMQTV-QQEQLLQETQAL------QQSFLSEKDSLLQRE 2510
Score = 60.1 bits (144), Expect = 8e-09
Identities = 105/477 (22%), Positives = 204/477 (42%), Gaps = 70/477 (14%)
Query: 88 RLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQ-QQRGQQELGRQADELKGVREESRRR 146
RLA+ +E L Q L+ + AQ +A+ + + QQR Q+E+ R+ + +++ R
Sbjct: 1365 RLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 147 RKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ--P 204
++ + L+Q ++ + R A AE + + +E+
Sbjct: 1423 QEELQQLRQ----------------------SSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 205 VEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLY 264
V LE + +GEL+A R + + Q+ Q + EA++ + +++ K
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQK----RQAQEEAERLRRQVQDESQRKRQ 1516
Query: 265 GEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQ 324
E++ + V + EK RALQ+ + L+ EE+E LRQA E++
Sbjct: 1517 AEVELASR--------VKAEAEAAREKQRALQALEELR-----LQAEEAERRLRQA-EVE 1562
Query: 325 ALREKTEIQKTEWKRKVKELHEEH--MAEK-KELQEENQRLQASLSQDQKKAAAQSQCQI 381
R+ +T + EL + AEK +L+ Q +++Q +++A ++Q Q
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622
Query: 382 STLRAQLQEQARIIASQEEMIQSLSLR-KVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
RA+ + + + Q + ++L LR + E + + E + +EE E + K
Sbjct: 1623 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1682
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRV-----QR 495
R R + E LE++ R+ A+G + Q L + L+R+ Q
Sbjct: 1683 AEEQAVRQ-------RELAEQELEKQ------RQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 496 EQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
EQ+ + E L+ +L +E + ++RQE A +++ + V A E++
Sbjct: 1730 EQQRQLLEEELA---RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Score = 56.2 bits (134), Expect = 1e-07
Identities = 106/498 (21%), Positives = 213/498 (42%), Gaps = 79/498 (15%)
Query: 101 QDCLSASVAQLEARLQTSLGQQQRG--QQELGRQADELKGVREESRRRR----KMISTLQ 154
Q L+A + R +T G+QQR ++EL R E ++ + K+ + ++
Sbjct: 1710 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1769
Query: 155 QLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQR------RHAGVAEGGKQKKQ------- 201
LL + +K+ G + R +AE K+++Q
Sbjct: 1770 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1829
Query: 202 --EQPVEEVLEELRA------KLKWTQGEL---EAQREAERQRQLQEAELIHQREIEA-- 248
E VL E A +LK T+ E+ E + E ER R+L E E +R +E
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 249 ---KKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSH------- 298
K + ++ Q E+++ K L D + Q +EE++ AL++
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLR----QRRQVEEEILALKASFEKAAAG 1944
Query: 299 -SVMESKLGSLRDEESEEWLR--QARELQALREKTEIQKTEWKRKVKE--------LHEE 347
+ +E +LG +R +E+ LR + EL+A R++ + E +R+ E EE
Sbjct: 1945 KAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Query: 348 HMAEKKELQEENQRLQASLSQ-------DQKKAAAQSQC--QISTLRAQLQEQARIIA-S 397
++K EE +RL+A + + ++++A Q Q + + R Q +E+A A
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063
Query: 398 QEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRP 457
Q+E +L++ + + + EE E+++ + + A RR + +
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2123
Query: 458 ILEDTLEEKLESMG----IRKDAKGISIQTLRHLESLLRVQRE-----QKARKFSE-FLS 507
E+ + + ++ +RK+A+ + + + ++ LR ++ +K +KF+E L
Sbjct: 2124 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2183
Query: 508 LRGKLVKEVTSRAKERQE 525
+ ++ +E+T+ + +E
Sbjct: 2184 QKAQVEQELTTLRLQLEE 2201
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/384 (22%), Positives = 170/384 (44%), Gaps = 60/384 (15%)
Query: 108 VAQLEARLQTS-----LGQQQRGQQELGRQADELKGVREESRR---RRKMISTLQQLLMQ 159
+++L+AR++ L + Q+ L +A+++K V EE+ R + + L+QL +
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 160 TGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQP--VEEVLEELRAKLK 217
K M A + + A + + K+ QEQ ++E E++ +L
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2362
Query: 218 WTQGELEAQREAERQRQLQ---EAELIHQREIEAKK----------EFDKWKEQEWTKLY 264
+ EAERQRQL+ EAE + R E + F K E+ KL+
Sbjct: 2363 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2422
Query: 265 G-EIDKLKKLFWDEFKNVAKQNSTLE-EKLRALQSHSVMESKLGSLRDEESEEWLRQARE 322
E+ +K+ + + +Q S + E+LR ++ + +E + L+ E L+ + E
Sbjct: 2423 RTELATQEKVTLVQTLEIQRQQSDHDAERLR--EAIAELEREKEKLQQEAKLLQLK-SEE 2479
Query: 323 LQALREKTEIQKT----------------------EWKRKVKELHEEHMAEKKELQEENQ 360
+Q ++++ +Q+T + K K+++L ++ +A+ ++L+EE Q
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
R Q + Q++++ A + R Q + + + QEE L+++E + + +
Sbjct: 2540 RQQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEE------LQQLEQQRRQQEEL 2590
Query: 421 DTEEDSPEEEMEDSQDEQHKVLAA 444
EE+ E +EQH+ A
Sbjct: 2591 LAEENQRLREQLQLLEEQHRAALA 2614
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/302 (23%), Positives = 137/302 (45%), Gaps = 34/302 (11%)
Query: 89 LAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELK-GVREESRRRR 147
LAQ L ++ ++ +A+ Q +L +++ Q E+ +A+ LK V E SR +
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2401
Query: 148 KMISTLQQLLMQTGT--HSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPV 205
+ Q+ Q H L T T ++ +R + + ++ +
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELA--TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2459
Query: 206 EEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEF---DKWKEQEWTK 262
E E+L+ + K Q + E + ++++ LQE + + Q + K +++ EQE K
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2519
Query: 263 LYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDE------ESEEW 316
L ++LF DE VAK EE+ R Q +L + +E E+EE
Sbjct: 2520 L-------EQLFQDE---VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569
Query: 317 LRQARELQALREKTEIQKTEWKRKVKE--LHEEHMAEKKELQEENQRLQASLSQDQKKAA 374
+R+ +E E+Q+ E +R+ +E L EE+ +++LQ ++ +A+L+ ++ A
Sbjct: 2570 VRRKQE--------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Query: 375 AQ 376
+Q
Sbjct: 2622 SQ 2623
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/511 (21%), Positives = 207/511 (40%), Gaps = 75/511 (14%)
Query: 109 AQLEARLQT--SLGQQQRGQQELGRQADELKGVRE-ESRRRRKMISTL----QQLLMQTG 161
AQ EA+ T +L + RG QE+G + + G R+ E R R+ ++ L Q +L QT
Sbjct: 1141 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1200
Query: 162 THSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEV-LEELRAKLKWTQ 220
++ + R A + + ++++Q Q + + +R +L+ Q
Sbjct: 1201 VRQREL----EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1256
Query: 221 GELEAQREAERQ-RQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK 279
LE E ER +++E + ++ I A K+++ +L KK
Sbjct: 1257 ALLE---EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK------P 1307
Query: 280 NVAKQNSTLEEKLRALQSHSVMESKLGS---------LRDEESEEWLRQARELQALREKT 330
V + ++ ++ L++H + L S LR E EE L + + +
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1367
Query: 331 EIQKT-EWKRKVKELHEEHMA----EKKELQEENQ-----RLQASLSQDQKKAAAQSQCQ 380
E++ E +R++ E H + A E KELQ+ Q R +A++ Q+K + Q + Q
Sbjct: 1368 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1427
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP---KAVDTEEDSPEEEMEDSQDE 437
LR + + + A Q E + LR E I V +A + + E E++ +
Sbjct: 1428 --QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1485
Query: 438 QHKVLAALRRNPTLLKHFRPILEDTLEEKLES---MGIRKDAKG-ISIQTLRHLESL--L 491
+ A R+ + R ++D + K ++ + R A+ + + R L++L L
Sbjct: 1486 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1545
Query: 492 RVQREQKARKF-----------------------SEFLSLRGKLVKEVTSRAKERQENGA 528
R+Q E+ R+ +E S R ++ + QE
Sbjct: 1546 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1605
Query: 529 AVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
AV+Q + ++QQ A R + R L+
Sbjct: 1606 AVAQLREEAERRAQQQAEAERAREEAERELE 1636
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/464 (20%), Positives = 178/464 (38%), Gaps = 51/464 (10%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
++QR Q L +EL+ EE+ RR + + +Q + + A+F
Sbjct: 1534 EKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 181 ------LRGHIQRRHAGVA----EGGKQKKQEQPVEEVLEELRAKL-KWTQGELEAQR-- 227
L +Q H VA E ++ +Q+ E EE +L +W EA R
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 228 ----EAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEI-----DKLKKLFWDEF 278
E +Q+ L +AE Q+E ++ + K +E E+ +K ++L
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA---- 1705
Query: 279 KNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ A+Q E++L L++ + + L +EE R+A R++ E +
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA--- 1762
Query: 339 RKVKELHEEHMAEKKELQEEN--------QRLQASLSQDQKKA--AAQSQCQISTLRAQL 388
KV+ E +A K +EE+ QRL+A + ++ A AA+ + + Q
Sbjct: 1763 -KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Query: 389 QEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRN 448
Q A Q + + K+ I + + + TE + +E E + ++
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 449 PTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSL 508
L+ + +EE+L + D++ L + L+ Q+ + E L+L
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSE------LERQKGLVEDTLRQRRQVEEEILAL 1934
Query: 509 RGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
+ K +A+ E G S + K Q R+ Q
Sbjct: 1935 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1978
Score = 43.1 bits (100), Expect = 0.001
Identities = 79/397 (19%), Positives = 147/397 (37%), Gaps = 53/397 (13%)
Query: 207 EVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGE 266
E L+ + ++ TQG E R E Q + +A E+EA K K KL +
Sbjct: 1090 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-------KLRAQ 1142
Query: 267 IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQAREL--- 323
+ + F L ++LR Q + RD E E W + +L
Sbjct: 1143 AEAQQPTF-----------DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191
Query: 324 -QALREKTEIQKTEWKRKVKELHEEH---------MAEKKELQEENQRLQASLSQDQKKA 373
QA+ +T++++ E ++ ++L + + + QE+ Q + + SQ ++
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251
Query: 374 AAQSQCQISTLR---AQLQEQARIIASQEEMIQSLSLRKVEGIHKV-PKAVDTEEDSPEE 429
Q Q + + +++E R I+ L+ V ++ P A ++ +
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1311
Query: 430 EMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLES 489
E E + TL + + +TL E + + + + L +E+
Sbjct: 1312 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1371
Query: 490 LLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTR 549
L QR+ + E ++AK + E A Q Q V ++ A V
Sbjct: 1372 ALEKQRQ----------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1415
Query: 550 EAQPKT--RTLQVALPSTPAEPPPPTRQSHGSHGSSL 584
+ Q ++ LQ S+ AE RQ+ + S L
Sbjct: 1416 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1452
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 67.4 bits (163), Expect = 5e-11
Identities = 118/518 (22%), Positives = 224/518 (43%), Gaps = 87/518 (16%)
Query: 108 VAQLEARLQTSLGQ---QQRGQQELGRQ-------ADELKGVREESRRRRKMISTL---- 153
VAQL R Q L Q +QR ++LGRQ AD L +++RRR++ I +
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 154 -----------QQLLMQTGTH--SYHTCHLCDKTFMNA----TFLRGHIQRRHAGVAEGG 196
Q LL + H C K ++NA + + VA
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGEL------------EAQREAERQRQLQEAELIHQR 244
K+ K + E V++E L+ EL E R E + +L E + +R
Sbjct: 1301 KKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1359
Query: 245 EIEAKKEFDKWKEQEWTKLYG--------EIDKLKKLFWDEF-------KNVAKQNSTLE 289
E A+ E K+++ + + E +L++ +E + +Q +++
Sbjct: 1360 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 290 EKLRALQSHSVMESKLGSLRDEESE-EWLRQARELQALR---EKTEIQKTEWKRKVKELH 345
E+L+ L+ S E + + + E +E LR E++ +R E TE Q+ + +++ L
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 346 ---EEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQI-STLRAQ----------LQEQ 391
EE A+K++ QEE +RL+ + QD+ + Q++ ++ S ++A+ LQ
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQV-QDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1538
Query: 392 ARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQ----DEQHKVLAALRR 447
+ EE + L +VE +V A++T + S E E++ + ++ ++ +L+
Sbjct: 1539 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 448 NPTLLKHFRPILEDTLEEKLESMGIRKDA-KGISIQTLRHLESL-LRVQREQKARKFSEF 505
+ R E +++ E+ R++A + + L+ E+L LR+Q E+ A++ S
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-- 1656
Query: 506 LSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQ 543
+ + K+ +E + G A Q Q + Q+
Sbjct: 1657 -LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Score = 62.4 bits (150), Expect = 2e-09
Identities = 112/531 (21%), Positives = 213/531 (40%), Gaps = 93/531 (17%)
Query: 70 EVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSA-SVAQLEARLQTSLGQQQRGQQE 128
E R + + + L+LAQ + L ++ A +V Q E LQ +L Q+Q
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS---- 2074
Query: 129 LGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRR 188
D+L+G E +RR + + + S RR
Sbjct: 2075 ---VLDQLRGEAEAARRAAEEAEEARVQAEREAAQS----------------------RR 2109
Query: 189 HAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGEL--EAQREAERQRQLQEAELIHQREI 246
AE KQ +EQ + RA+ + +L EA++EA R+ Q ++A L ++
Sbjct: 2110 QVEEAERLKQSAEEQA------QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 247 EAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLG 306
+A+ E K ++ + ++++ + + Q + L+E+L+ L++ + ++
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 307 SLRDEESEEWLRQARELQALREKTEIQK---------------TEWKRKVKELHEE---- 347
S +EE Q EL L+ + E + E K+K++ EE
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283
Query: 348 -----HMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQ----------LQEQA 392
A ++L EE+ Q +L++ K Q+ + + L+A+ QEQA
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 393 RIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
R + +E + + +G + +A + E E + ++ A R
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTL------------RHLESLLRVQRE-QKA 499
+ FR E+ + EKL + K +QTL R E++ ++RE +K
Sbjct: 2404 QRFRKQAEE-IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2462
Query: 500 RKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTRE 550
++ ++ L L+ + ++ V + + QE A Q S S++ +L+ RE
Sbjct: 2463 QQEAKLLQLKSEEMQTV-QQEQLLQETQAL------QQSFLSEKDSLLQRE 2506
Score = 60.1 bits (144), Expect = 8e-09
Identities = 105/477 (22%), Positives = 204/477 (42%), Gaps = 70/477 (14%)
Query: 88 RLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQ-QQRGQQELGRQADELKGVREESRRR 146
RLA+ +E L Q L+ + AQ +A+ + + QQR Q+E+ R+ + +++ R
Sbjct: 1361 RLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 147 RKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ--P 204
++ + L+Q ++ + R A AE + + +E+
Sbjct: 1419 QEELQQLRQ----------------------SSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 205 VEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLY 264
V LE + +GEL+A R + + Q+ Q + EA++ + +++ K
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQK----RQAQEEAERLRRQVQDESQRKRQ 1512
Query: 265 GEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQ 324
E++ + V + EK RALQ+ + L+ EE+E LRQA E++
Sbjct: 1513 AEVELASR--------VKAEAEAAREKQRALQALEELR-----LQAEEAERRLRQA-EVE 1558
Query: 325 ALREKTEIQKTEWKRKVKELHEEH--MAEK-KELQEENQRLQASLSQDQKKAAAQSQCQI 381
R+ +T + EL + AEK +L+ Q +++Q +++A ++Q Q
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 382 STLRAQLQEQARIIASQEEMIQSLSLR-KVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
RA+ + + + Q + ++L LR + E + + E + +EE E + K
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRV-----QR 495
R R + E LE++ R+ A+G + Q L + L+R+ Q
Sbjct: 1679 AEEQAVRQ-------RELAEQELEKQ------RQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 496 EQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
EQ+ + E L+ +L +E + ++RQE A +++ + V A E++
Sbjct: 1726 EQQRQLLEEELA---RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Score = 56.2 bits (134), Expect = 1e-07
Identities = 106/498 (21%), Positives = 213/498 (42%), Gaps = 79/498 (15%)
Query: 101 QDCLSASVAQLEARLQTSLGQQQRG--QQELGRQADELKGVREESRRRR----KMISTLQ 154
Q L+A + R +T G+QQR ++EL R E ++ + K+ + ++
Sbjct: 1706 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1765
Query: 155 QLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQR------RHAGVAEGGKQKKQ------- 201
LL + +K+ G + R +AE K+++Q
Sbjct: 1766 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1825
Query: 202 --EQPVEEVLEELRA------KLKWTQGEL---EAQREAERQRQLQEAELIHQREIEA-- 248
E VL E A +LK T+ E+ E + E ER R+L E E +R +E
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 249 ---KKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSH------- 298
K + ++ Q E+++ K L D + Q +EE++ AL++
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLR----QRRQVEEEILALKASFEKAAAG 1940
Query: 299 -SVMESKLGSLRDEESEEWLR--QARELQALREKTEIQKTEWKRKVKE--------LHEE 347
+ +E +LG +R +E+ LR + EL+A R++ + E +R+ E EE
Sbjct: 1941 KAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 348 HMAEKKELQEENQRLQASLSQ-------DQKKAAAQSQC--QISTLRAQLQEQARIIA-S 397
++K EE +RL+A + + ++++A Q Q + + R Q +E+A A
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 398 QEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRP 457
Q+E +L++ + + + EE E+++ + + A RR + +
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2119
Query: 458 ILEDTLEEKLESMG----IRKDAKGISIQTLRHLESLLRVQRE-----QKARKFSE-FLS 507
E+ + + ++ +RK+A+ + + + ++ LR ++ +K +KF+E L
Sbjct: 2120 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2179
Query: 508 LRGKLVKEVTSRAKERQE 525
+ ++ +E+T+ + +E
Sbjct: 2180 QKAQVEQELTTLRLQLEE 2197
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/384 (22%), Positives = 170/384 (44%), Gaps = 60/384 (15%)
Query: 108 VAQLEARLQTS-----LGQQQRGQQELGRQADELKGVREESRR---RRKMISTLQQLLMQ 159
+++L+AR++ L + Q+ L +A+++K V EE+ R + + L+QL +
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 160 TGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQP--VEEVLEELRAKLK 217
K M A + + A + + K+ QEQ ++E E++ +L
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2358
Query: 218 WTQGELEAQREAERQRQLQ---EAELIHQREIEAKK----------EFDKWKEQEWTKLY 264
+ EAERQRQL+ EAE + R E + F K E+ KL+
Sbjct: 2359 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2418
Query: 265 G-EIDKLKKLFWDEFKNVAKQNSTLE-EKLRALQSHSVMESKLGSLRDEESEEWLRQARE 322
E+ +K+ + + +Q S + E+LR ++ + +E + L+ E L+ + E
Sbjct: 2419 RTELATQEKVTLVQTLEIQRQQSDHDAERLR--EAIAELEREKEKLQQEAKLLQLK-SEE 2475
Query: 323 LQALREKTEIQKT----------------------EWKRKVKELHEEHMAEKKELQEENQ 360
+Q ++++ +Q+T + K K+++L ++ +A+ ++L+EE Q
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
R Q + Q++++ A + R Q + + + QEE L+++E + + +
Sbjct: 2536 RQQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEE------LQQLEQQRRQQEEL 2586
Query: 421 DTEEDSPEEEMEDSQDEQHKVLAA 444
EE+ E +EQH+ A
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALA 2610
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/302 (23%), Positives = 137/302 (45%), Gaps = 34/302 (11%)
Query: 89 LAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELK-GVREESRRRR 147
LAQ L ++ ++ +A+ Q +L +++ Q E+ +A+ LK V E SR +
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2397
Query: 148 KMISTLQQLLMQTGT--HSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPV 205
+ Q+ Q H L T T ++ +R + + ++ +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELA--TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2455
Query: 206 EEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEF---DKWKEQEWTK 262
E E+L+ + K Q + E + ++++ LQE + + Q + K +++ EQE K
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515
Query: 263 LYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDE------ESEEW 316
L ++LF DE VAK EE+ R Q +L + +E E+EE
Sbjct: 2516 L-------EQLFQDE---VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 317 LRQARELQALREKTEIQKTEWKRKVKE--LHEEHMAEKKELQEENQRLQASLSQDQKKAA 374
+R+ +E E+Q+ E +R+ +E L EE+ +++LQ ++ +A+L+ ++ A
Sbjct: 2566 VRRKQE--------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 375 AQ 376
+Q
Sbjct: 2618 SQ 2619
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/511 (21%), Positives = 207/511 (40%), Gaps = 75/511 (14%)
Query: 109 AQLEARLQT--SLGQQQRGQQELGRQADELKGVRE-ESRRRRKMISTL----QQLLMQTG 161
AQ EA+ T +L + RG QE+G + + G R+ E R R+ ++ L Q +L QT
Sbjct: 1137 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196
Query: 162 THSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEV-LEELRAKLKWTQ 220
++ + R A + + ++++Q Q + + +R +L+ Q
Sbjct: 1197 VRQREL----EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1252
Query: 221 GELEAQREAERQ-RQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK 279
LE E ER +++E + ++ I A K+++ +L KK
Sbjct: 1253 ALLE---EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK------P 1303
Query: 280 NVAKQNSTLEEKLRALQSHSVMESKLGS---------LRDEESEEWLRQARELQALREKT 330
V + ++ ++ L++H + L S LR E EE L + + +
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1363
Query: 331 EIQKT-EWKRKVKELHEEHMA----EKKELQEENQ-----RLQASLSQDQKKAAAQSQCQ 380
E++ E +R++ E H + A E KELQ+ Q R +A++ Q+K + Q + Q
Sbjct: 1364 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1423
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP---KAVDTEEDSPEEEMEDSQDE 437
LR + + + A Q E + LR E I V +A + + E E++ +
Sbjct: 1424 --QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 438 QHKVLAALRRNPTLLKHFRPILEDTLEEKLES---MGIRKDAKG-ISIQTLRHLESL--L 491
+ A R+ + R ++D + K ++ + R A+ + + R L++L L
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 492 RVQREQKARKF-----------------------SEFLSLRGKLVKEVTSRAKERQENGA 528
R+Q E+ R+ +E S R ++ + QE
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1601
Query: 529 AVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
AV+Q + ++QQ A R + R L+
Sbjct: 1602 AVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/464 (20%), Positives = 178/464 (38%), Gaps = 51/464 (10%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
++QR Q L +EL+ EE+ RR + + +Q + + A+F
Sbjct: 1530 EKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 181 ------LRGHIQRRHAGVA----EGGKQKKQEQPVEEVLEELRAKL-KWTQGELEAQR-- 227
L +Q H VA E ++ +Q+ E EE +L +W EA R
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 228 ----EAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEI-----DKLKKLFWDEF 278
E +Q+ L +AE Q+E ++ + K +E E+ +K ++L
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA---- 1701
Query: 279 KNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ A+Q E++L L++ + + L +EE R+A R++ E +
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA--- 1758
Query: 339 RKVKELHEEHMAEKKELQEEN--------QRLQASLSQDQKKA--AAQSQCQISTLRAQL 388
KV+ E +A K +EE+ QRL+A + ++ A AA+ + + Q
Sbjct: 1759 -KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 389 QEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRN 448
Q A Q + + K+ I + + + TE + +E E + ++
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 449 PTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSL 508
L+ + +EE+L + D++ L + L+ Q+ + E L+L
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSE------LERQKGLVEDTLRQRRQVEEEILAL 1930
Query: 509 RGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
+ K +A+ E G S + K Q R+ Q
Sbjct: 1931 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1974
Score = 43.1 bits (100), Expect = 0.001
Identities = 79/397 (19%), Positives = 147/397 (37%), Gaps = 53/397 (13%)
Query: 207 EVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGE 266
E L+ + ++ TQG E R E Q + +A E+EA K K KL +
Sbjct: 1086 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-------KLRAQ 1138
Query: 267 IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQAREL--- 323
+ + F L ++LR Q + RD E E W + +L
Sbjct: 1139 AEAQQPTF-----------DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 324 -QALREKTEIQKTEWKRKVKELHEEH---------MAEKKELQEENQRLQASLSQDQKKA 373
QA+ +T++++ E ++ ++L + + + QE+ Q + + SQ ++
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 374 AAQSQCQISTLR---AQLQEQARIIASQEEMIQSLSLRKVEGIHKV-PKAVDTEEDSPEE 429
Q Q + + +++E R I+ L+ V ++ P A ++ +
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1307
Query: 430 EMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLES 489
E E + TL + + +TL E + + + + L +E+
Sbjct: 1308 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1367
Query: 490 LLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTR 549
L QR+ + E ++AK + E A Q Q V ++ A V
Sbjct: 1368 ALEKQRQ----------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1411
Query: 550 EAQPKT--RTLQVALPSTPAEPPPPTRQSHGSHGSSL 584
+ Q ++ LQ S+ AE RQ+ + S L
Sbjct: 1412 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1448
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 67.4 bits (163), Expect = 5e-11
Identities = 118/518 (22%), Positives = 224/518 (43%), Gaps = 87/518 (16%)
Query: 108 VAQLEARLQTSLGQ---QQRGQQELGRQ-------ADELKGVREESRRRRKMISTL---- 153
VAQL R Q L Q +QR ++LGRQ AD L +++RRR++ I +
Sbjct: 1149 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1208
Query: 154 -----------QQLLMQTGTH--SYHTCHLCDKTFMNA----TFLRGHIQRRHAGVAEGG 196
Q LL + H C K ++NA + + VA
Sbjct: 1209 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1268
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGEL------------EAQREAERQRQLQEAELIHQR 244
K+ K + E V++E L+ EL E R E + +L E + +R
Sbjct: 1269 KKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1327
Query: 245 EIEAKKEFDKWKEQEWTKLYG--------EIDKLKKLFWDEF-------KNVAKQNSTLE 289
E A+ E K+++ + + E +L++ +E + +Q +++
Sbjct: 1328 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 290 EKLRALQSHSVMESKLGSLRDEESE-EWLRQARELQALR---EKTEIQKTEWKRKVKELH 345
E+L+ L+ S E + + + E +E LR E++ +R E TE Q+ + +++ L
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 346 ---EEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQI-STLRAQ----------LQEQ 391
EE A+K++ QEE +RL+ + QD+ + Q++ ++ S ++A+ LQ
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQV-QDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1506
Query: 392 ARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQ----DEQHKVLAALRR 447
+ EE + L +VE +V A++T + S E E++ + ++ ++ +L+
Sbjct: 1507 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566
Query: 448 NPTLLKHFRPILEDTLEEKLESMGIRKDA-KGISIQTLRHLESL-LRVQREQKARKFSEF 505
+ R E +++ E+ R++A + + L+ E+L LR+Q E+ A++ S
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-- 1624
Query: 506 LSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQ 543
+ + K+ +E + G A Q Q + Q+
Sbjct: 1625 -LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Score = 62.4 bits (150), Expect = 2e-09
Identities = 112/531 (21%), Positives = 213/531 (40%), Gaps = 93/531 (17%)
Query: 70 EVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSA-SVAQLEARLQTSLGQQQRGQQE 128
E R + + + L+LAQ + L ++ A +V Q E LQ +L Q+Q
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS---- 2042
Query: 129 LGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRR 188
D+L+G E +RR + + + S RR
Sbjct: 2043 ---VLDQLRGEAEAARRAAEEAEEARVQAEREAAQS----------------------RR 2077
Query: 189 HAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGEL--EAQREAERQRQLQEAELIHQREI 246
AE KQ +EQ + RA+ + +L EA++EA R+ Q ++A L ++
Sbjct: 2078 QVEEAERLKQSAEEQA------QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 247 EAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLG 306
+A+ E K ++ + ++++ + + Q + L+E+L+ L++ + ++
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Query: 307 SLRDEESEEWLRQARELQALREKTEIQK---------------TEWKRKVKELHEE---- 347
S +EE Q EL L+ + E + E K+K++ EE
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251
Query: 348 -----HMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQ----------LQEQA 392
A ++L EE+ Q +L++ K Q+ + + L+A+ QEQA
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311
Query: 393 RIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
R + +E + + +G + +A + E E + ++ A R
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTL------------RHLESLLRVQRE-QKA 499
+ FR E+ + EKL + K +QTL R E++ ++RE +K
Sbjct: 2372 QRFRKQAEE-IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2430
Query: 500 RKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTRE 550
++ ++ L L+ + ++ V + + QE A Q S S++ +L+ RE
Sbjct: 2431 QQEAKLLQLKSEEMQTV-QQEQLLQETQAL------QQSFLSEKDSLLQRE 2474
Score = 60.1 bits (144), Expect = 8e-09
Identities = 105/477 (22%), Positives = 204/477 (42%), Gaps = 70/477 (14%)
Query: 88 RLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQ-QQRGQQELGRQADELKGVREESRRR 146
RLA+ +E L Q L+ + AQ +A+ + + QQR Q+E+ R+ + +++ R
Sbjct: 1329 RLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1386
Query: 147 RKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ--P 204
++ + L+Q ++ + R A AE + + +E+
Sbjct: 1387 QEELQQLRQ----------------------SSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 205 VEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLY 264
V LE + +GEL+A R + + Q+ Q + EA++ + +++ K
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQK----RQAQEEAERLRRQVQDESQRKRQ 1480
Query: 265 GEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQ 324
E++ + V + EK RALQ+ + L+ EE+E LRQA E++
Sbjct: 1481 AEVELASR--------VKAEAEAAREKQRALQALEELR-----LQAEEAERRLRQA-EVE 1526
Query: 325 ALREKTEIQKTEWKRKVKELHEEH--MAEK-KELQEENQRLQASLSQDQKKAAAQSQCQI 381
R+ +T + EL + AEK +L+ Q +++Q +++A ++Q Q
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586
Query: 382 STLRAQLQEQARIIASQEEMIQSLSLR-KVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
RA+ + + + Q + ++L LR + E + + E + +EE E + K
Sbjct: 1587 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1646
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRV-----QR 495
R R + E LE++ R+ A+G + Q L + L+R+ Q
Sbjct: 1647 AEEQAVRQ-------RELAEQELEKQ------RQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 496 EQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
EQ+ + E L+ +L +E + ++RQE A +++ + V A E++
Sbjct: 1694 EQQRQLLEEELA---RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Score = 56.2 bits (134), Expect = 1e-07
Identities = 106/498 (21%), Positives = 213/498 (42%), Gaps = 79/498 (15%)
Query: 101 QDCLSASVAQLEARLQTSLGQQQRG--QQELGRQADELKGVREESRRRR----KMISTLQ 154
Q L+A + R +T G+QQR ++EL R E ++ + K+ + ++
Sbjct: 1674 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1733
Query: 155 QLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQR------RHAGVAEGGKQKKQ------- 201
LL + +K+ G + R +AE K+++Q
Sbjct: 1734 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1793
Query: 202 --EQPVEEVLEELRA------KLKWTQGEL---EAQREAERQRQLQEAELIHQREIEA-- 248
E VL E A +LK T+ E+ E + E ER R+L E E +R +E
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 249 ---KKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSH------- 298
K + ++ Q E+++ K L D + Q +EE++ AL++
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLR----QRRQVEEEILALKASFEKAAAG 1908
Query: 299 -SVMESKLGSLRDEESEEWLR--QARELQALREKTEIQKTEWKRKVKE--------LHEE 347
+ +E +LG +R +E+ LR + EL+A R++ + E +R+ E EE
Sbjct: 1909 KAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Query: 348 HMAEKKELQEENQRLQASLSQ-------DQKKAAAQSQC--QISTLRAQLQEQARIIA-S 397
++K EE +RL+A + + ++++A Q Q + + R Q +E+A A
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027
Query: 398 QEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRP 457
Q+E +L++ + + + EE E+++ + + A RR + +
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2087
Query: 458 ILEDTLEEKLESMG----IRKDAKGISIQTLRHLESLLRVQRE-----QKARKFSE-FLS 507
E+ + + ++ +RK+A+ + + + ++ LR ++ +K +KF+E L
Sbjct: 2088 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2147
Query: 508 LRGKLVKEVTSRAKERQE 525
+ ++ +E+T+ + +E
Sbjct: 2148 QKAQVEQELTTLRLQLEE 2165
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/384 (22%), Positives = 170/384 (44%), Gaps = 60/384 (15%)
Query: 108 VAQLEARLQTS-----LGQQQRGQQELGRQADELKGVREESRR---RRKMISTLQQLLMQ 159
+++L+AR++ L + Q+ L +A+++K V EE+ R + + L+QL +
Sbjct: 2208 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 160 TGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQP--VEEVLEELRAKLK 217
K M A + + A + + K+ QEQ ++E E++ +L
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2326
Query: 218 WTQGELEAQREAERQRQLQ---EAELIHQREIEAKK----------EFDKWKEQEWTKLY 264
+ EAERQRQL+ EAE + R E + F K E+ KL+
Sbjct: 2327 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2386
Query: 265 G-EIDKLKKLFWDEFKNVAKQNSTLE-EKLRALQSHSVMESKLGSLRDEESEEWLRQARE 322
E+ +K+ + + +Q S + E+LR ++ + +E + L+ E L+ + E
Sbjct: 2387 RTELATQEKVTLVQTLEIQRQQSDHDAERLR--EAIAELEREKEKLQQEAKLLQLK-SEE 2443
Query: 323 LQALREKTEIQKT----------------------EWKRKVKELHEEHMAEKKELQEENQ 360
+Q ++++ +Q+T + K K+++L ++ +A+ ++L+EE Q
Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
R Q + Q++++ A + R Q + + + QEE L+++E + + +
Sbjct: 2504 RQQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEE------LQQLEQQRRQQEEL 2554
Query: 421 DTEEDSPEEEMEDSQDEQHKVLAA 444
EE+ E +EQH+ A
Sbjct: 2555 LAEENQRLREQLQLLEEQHRAALA 2578
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/302 (23%), Positives = 137/302 (45%), Gaps = 34/302 (11%)
Query: 89 LAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELK-GVREESRRRR 147
LAQ L ++ ++ +A+ Q +L +++ Q E+ +A+ LK V E SR +
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2365
Query: 148 KMISTLQQLLMQTGT--HSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPV 205
+ Q+ Q H L T T ++ +R + + ++ +
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELA--TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2423
Query: 206 EEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEF---DKWKEQEWTK 262
E E+L+ + K Q + E + ++++ LQE + + Q + K +++ EQE K
Sbjct: 2424 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2483
Query: 263 LYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDE------ESEEW 316
L ++LF DE VAK EE+ R Q +L + +E E+EE
Sbjct: 2484 L-------EQLFQDE---VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533
Query: 317 LRQARELQALREKTEIQKTEWKRKVKE--LHEEHMAEKKELQEENQRLQASLSQDQKKAA 374
+R+ +E E+Q+ E +R+ +E L EE+ +++LQ ++ +A+L+ ++ A
Sbjct: 2534 VRRKQE--------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585
Query: 375 AQ 376
+Q
Sbjct: 2586 SQ 2587
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/511 (21%), Positives = 207/511 (40%), Gaps = 75/511 (14%)
Query: 109 AQLEARLQT--SLGQQQRGQQELGRQADELKGVRE-ESRRRRKMISTL----QQLLMQTG 161
AQ EA+ T +L + RG QE+G + + G R+ E R R+ ++ L Q +L QT
Sbjct: 1105 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1164
Query: 162 THSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEV-LEELRAKLKWTQ 220
++ + R A + + ++++Q Q + + +R +L+ Q
Sbjct: 1165 VRQREL----EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1220
Query: 221 GELEAQREAERQ-RQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK 279
LE E ER +++E + ++ I A K+++ +L KK
Sbjct: 1221 ALLE---EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK------P 1271
Query: 280 NVAKQNSTLEEKLRALQSHSVMESKLGS---------LRDEESEEWLRQARELQALREKT 330
V + ++ ++ L++H + L S LR E EE L + + +
Sbjct: 1272 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1331
Query: 331 EIQKT-EWKRKVKELHEEHMA----EKKELQEENQ-----RLQASLSQDQKKAAAQSQCQ 380
E++ E +R++ E H + A E KELQ+ Q R +A++ Q+K + Q + Q
Sbjct: 1332 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1391
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP---KAVDTEEDSPEEEMEDSQDE 437
LR + + + A Q E + LR E I V +A + + E E++ +
Sbjct: 1392 --QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1449
Query: 438 QHKVLAALRRNPTLLKHFRPILEDTLEEKLES---MGIRKDAKG-ISIQTLRHLESL--L 491
+ A R+ + R ++D + K ++ + R A+ + + R L++L L
Sbjct: 1450 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1509
Query: 492 RVQREQKARKF-----------------------SEFLSLRGKLVKEVTSRAKERQENGA 528
R+Q E+ R+ +E S R ++ + QE
Sbjct: 1510 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1569
Query: 529 AVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
AV+Q + ++QQ A R + R L+
Sbjct: 1570 AVAQLREEAERRAQQQAEAERAREEAERELE 1600
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/464 (20%), Positives = 178/464 (38%), Gaps = 51/464 (10%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
++QR Q L +EL+ EE+ RR + + +Q + + A+F
Sbjct: 1498 EKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 181 ------LRGHIQRRHAGVA----EGGKQKKQEQPVEEVLEELRAKL-KWTQGELEAQR-- 227
L +Q H VA E ++ +Q+ E EE +L +W EA R
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 228 ----EAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEI-----DKLKKLFWDEF 278
E +Q+ L +AE Q+E ++ + K +E E+ +K ++L
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA---- 1669
Query: 279 KNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ A+Q E++L L++ + + L +EE R+A R++ E +
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA--- 1726
Query: 339 RKVKELHEEHMAEKKELQEEN--------QRLQASLSQDQKKA--AAQSQCQISTLRAQL 388
KV+ E +A K +EE+ QRL+A + ++ A AA+ + + Q
Sbjct: 1727 -KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Query: 389 QEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRN 448
Q A Q + + K+ I + + + TE + +E E + ++
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 449 PTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSL 508
L+ + +EE+L + D++ L + L+ Q+ + E L+L
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSE------LERQKGLVEDTLRQRRQVEEEILAL 1898
Query: 509 RGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
+ K +A+ E G S + K Q R+ Q
Sbjct: 1899 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1942
Score = 43.1 bits (100), Expect = 0.001
Identities = 79/397 (19%), Positives = 147/397 (37%), Gaps = 53/397 (13%)
Query: 207 EVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGE 266
E L+ + ++ TQG E R E Q + +A E+EA K K KL +
Sbjct: 1054 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-------KLRAQ 1106
Query: 267 IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQAREL--- 323
+ + F L ++LR Q + RD E E W + +L
Sbjct: 1107 AEAQQPTF-----------DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1155
Query: 324 -QALREKTEIQKTEWKRKVKELHEEH---------MAEKKELQEENQRLQASLSQDQKKA 373
QA+ +T++++ E ++ ++L + + + QE+ Q + + SQ ++
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 374 AAQSQCQISTLR---AQLQEQARIIASQEEMIQSLSLRKVEGIHKV-PKAVDTEEDSPEE 429
Q Q + + +++E R I+ L+ V ++ P A ++ +
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1275
Query: 430 EMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLES 489
E E + TL + + +TL E + + + + L +E+
Sbjct: 1276 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1335
Query: 490 LLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTR 549
L QR+ + E ++AK + E A Q Q V ++ A V
Sbjct: 1336 ALEKQRQ----------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1379
Query: 550 EAQPKT--RTLQVALPSTPAEPPPPTRQSHGSHGSSL 584
+ Q ++ LQ S+ AE RQ+ + S L
Sbjct: 1380 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1416
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 67.4 bits (163), Expect = 5e-11
Identities = 118/518 (22%), Positives = 224/518 (43%), Gaps = 87/518 (16%)
Query: 108 VAQLEARLQTSLGQ---QQRGQQELGRQ-------ADELKGVREESRRRRKMISTL---- 153
VAQL R Q L Q +QR ++LGRQ AD L +++RRR++ I +
Sbjct: 1318 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1377
Query: 154 -----------QQLLMQTGTH--SYHTCHLCDKTFMNA----TFLRGHIQRRHAGVAEGG 196
Q LL + H C K ++NA + + VA
Sbjct: 1378 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1437
Query: 197 KQKKQEQPVEEVLEELRAKLKWTQGEL------------EAQREAERQRQLQEAELIHQR 244
K+ K + E V++E L+ EL E R E + +L E + +R
Sbjct: 1438 KKPKVQSGSESVIQEY-VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496
Query: 245 EIEAKKEFDKWKEQEWTKLYG--------EIDKLKKLFWDEF-------KNVAKQNSTLE 289
E A+ E K+++ + + E +L++ +E + +Q +++
Sbjct: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 290 EKLRALQSHSVMESKLGSLRDEESE-EWLRQARELQALR---EKTEIQKTEWKRKVKELH 345
E+L+ L+ S E + + + E +E LR E++ +R E TE Q+ + +++ L
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616
Query: 346 ---EEHMAEKKELQEENQRLQASLSQDQKKAAAQSQCQI-STLRAQ----------LQEQ 391
EE A+K++ QEE +RL+ + QD+ + Q++ ++ S ++A+ LQ
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQV-QDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1675
Query: 392 ARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQ----DEQHKVLAALRR 447
+ EE + L +VE +V A++T + S E E++ + ++ ++ +L+
Sbjct: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735
Query: 448 NPTLLKHFRPILEDTLEEKLESMGIRKDA-KGISIQTLRHLESL-LRVQREQKARKFSEF 505
+ R E +++ E+ R++A + + L+ E+L LR+Q E+ A++ S
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-- 1793
Query: 506 LSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQ 543
+ + K+ +E + G A Q Q + Q+
Sbjct: 1794 -LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Score = 62.4 bits (150), Expect = 2e-09
Identities = 112/531 (21%), Positives = 213/531 (40%), Gaps = 93/531 (17%)
Query: 70 EVCSRCGQPVDPALLKVLRLAQLIIEYLLHCQDCLSA-SVAQLEARLQTSLGQQQRGQQE 128
E R + + + L+LAQ + L ++ A +V Q E LQ +L Q+Q
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS---- 2211
Query: 129 LGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRR 188
D+L+G E +RR + + + S RR
Sbjct: 2212 ---VLDQLRGEAEAARRAAEEAEEARVQAEREAAQS----------------------RR 2246
Query: 189 HAGVAEGGKQKKQEQPVEEVLEELRAKLKWTQGEL--EAQREAERQRQLQEAELIHQREI 246
AE KQ +EQ + RA+ + +L EA++EA R+ Q ++A L ++
Sbjct: 2247 QVEEAERLKQSAEEQA------QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 247 EAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLG 306
+A+ E K ++ + ++++ + + Q + L+E+L+ L++ + ++
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Query: 307 SLRDEESEEWLRQARELQALREKTEIQK---------------TEWKRKVKELHEE---- 347
S +EE Q EL L+ + E + E K+K++ EE
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420
Query: 348 -----HMAEKKELQEENQRLQASLSQDQKKAAAQSQCQISTLRAQ----------LQEQA 392
A ++L EE+ Q +L++ K Q+ + + L+A+ QEQA
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480
Query: 393 RIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLL 452
R + +E + + +G + +A + E E + ++ A R
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540
Query: 453 KHFRPILEDTLEEKLESMGIRKDAKGISIQTL------------RHLESLLRVQRE-QKA 499
+ FR E+ + EKL + K +QTL R E++ ++RE +K
Sbjct: 2541 QRFRKQAEE-IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL 2599
Query: 500 RKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTRE 550
++ ++ L L+ + ++ V + + QE A Q S S++ +L+ RE
Sbjct: 2600 QQEAKLLQLKSEEMQTV-QQEQLLQETQAL------QQSFLSEKDSLLQRE 2643
Score = 60.1 bits (144), Expect = 8e-09
Identities = 105/477 (22%), Positives = 204/477 (42%), Gaps = 70/477 (14%)
Query: 88 RLAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQ-QQRGQQELGRQADELKGVREESRRR 146
RLA+ +E L Q L+ + AQ +A+ + + QQR Q+E+ R+ + +++ R
Sbjct: 1498 RLAE--VEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555
Query: 147 RKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQ--P 204
++ + L+Q ++ + R A AE + + +E+
Sbjct: 1556 QEELQQLRQ----------------------SSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 205 VEEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLY 264
V LE + +GEL+A R + + Q+ Q + EA++ + +++ K
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQK----RQAQEEAERLRRQVQDESQRKRQ 1649
Query: 265 GEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQ 324
E++ + V + EK RALQ+ + L+ EE+E LRQA E++
Sbjct: 1650 AEVELASR--------VKAEAEAAREKQRALQALEELR-----LQAEEAERRLRQA-EVE 1695
Query: 325 ALREKTEIQKTEWKRKVKELHEEH--MAEK-KELQEENQRLQASLSQDQKKAAAQSQCQI 381
R+ +T + EL + AEK +L+ Q +++Q +++A ++Q Q
Sbjct: 1696 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1755
Query: 382 STLRAQLQEQARIIASQEEMIQSLSLR-KVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHK 440
RA+ + + + Q + ++L LR + E + + E + +EE E + K
Sbjct: 1756 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1815
Query: 441 VLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRV-----QR 495
R R + E LE++ R+ A+G + Q L + L+R+ Q
Sbjct: 1816 AEEQAVRQ-------RELAEQELEKQ------RQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 496 EQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
EQ+ + E L+ +L +E + ++RQE A +++ + V A E++
Sbjct: 1863 EQQRQLLEEELA---RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Score = 56.2 bits (134), Expect = 1e-07
Identities = 106/498 (21%), Positives = 213/498 (42%), Gaps = 79/498 (15%)
Query: 101 QDCLSASVAQLEARLQTSLGQQQRG--QQELGRQADELKGVREESRRRR----KMISTLQ 154
Q L+A + R +T G+QQR ++EL R E ++ + K+ + ++
Sbjct: 1843 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEME 1902
Query: 155 QLLMQTGTHSYHTCHLCDKTFMNATFLRGHIQR------RHAGVAEGGKQKKQ------- 201
LL + +K+ G + R +AE K+++Q
Sbjct: 1903 VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1962
Query: 202 --EQPVEEVLEELRA------KLKWTQGEL---EAQREAERQRQLQEAELIHQREIEA-- 248
E VL E A +LK T+ E+ E + E ER R+L E E +R +E
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 249 ---KKEFDKWKEQEWTKLYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSH------- 298
K + ++ Q E+++ K L D + Q +EE++ AL++
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLR----QRRQVEEEILALKASFEKAAAG 2077
Query: 299 -SVMESKLGSLRDEESEEWLR--QARELQALREKTEIQKTEWKRKVKE--------LHEE 347
+ +E +LG +R +E+ LR + EL+A R++ + E +R+ E EE
Sbjct: 2078 KAELELELGRIRSN-AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Query: 348 HMAEKKELQEENQRLQASLSQ-------DQKKAAAQSQC--QISTLRAQLQEQARIIA-S 397
++K EE +RL+A + + ++++A Q Q + + R Q +E+A A
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196
Query: 398 QEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRNPTLLKHFRP 457
Q+E +L++ + + + EE E+++ + + A RR + +
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQ 2256
Query: 458 ILEDTLEEKLESMG----IRKDAKGISIQTLRHLESLLRVQRE-----QKARKFSE-FLS 507
E+ + + ++ +RK+A+ + + + ++ LR ++ +K +KF+E L
Sbjct: 2257 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316
Query: 508 LRGKLVKEVTSRAKERQE 525
+ ++ +E+T+ + +E
Sbjct: 2317 QKAQVEQELTTLRLQLEE 2334
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/384 (22%), Positives = 170/384 (44%), Gaps = 60/384 (15%)
Query: 108 VAQLEARLQTS-----LGQQQRGQQELGRQADELKGVREESRR---RRKMISTLQQLLMQ 159
+++L+AR++ L + Q+ L +A+++K V EE+ R + + L+QL +
Sbjct: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 160 TGTHSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQP--VEEVLEELRAKLK 217
K M A + + A + + K+ QEQ ++E E++ +L
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRL-KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495
Query: 218 WTQGELEAQREAERQRQLQ---EAELIHQREIEAKK----------EFDKWKEQEWTKLY 264
+ EAERQRQL+ EAE + R E + F K E+ KL+
Sbjct: 2496 EETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH 2555
Query: 265 G-EIDKLKKLFWDEFKNVAKQNSTLE-EKLRALQSHSVMESKLGSLRDEESEEWLRQARE 322
E+ +K+ + + +Q S + E+LR ++ + +E + L+ E L+ + E
Sbjct: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAERLR--EAIAELEREKEKLQQEAKLLQLK-SEE 2612
Query: 323 LQALREKTEIQKT----------------------EWKRKVKELHEEHMAEKKELQEENQ 360
+Q ++++ +Q+T + K K+++L ++ +A+ ++L+EE Q
Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672
Query: 361 RLQASLSQDQKKAAAQSQCQISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVPKAV 420
R Q + Q++++ A + R Q + + + QEE L+++E + + +
Sbjct: 2673 RQQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEE------LQQLEQQRRQQEEL 2723
Query: 421 DTEEDSPEEEMEDSQDEQHKVLAA 444
EE+ E +EQH+ A
Sbjct: 2724 LAEENQRLREQLQLLEEQHRAALA 2747
Score = 54.3 bits (129), Expect = 4e-07
Identities = 71/302 (23%), Positives = 137/302 (45%), Gaps = 34/302 (11%)
Query: 89 LAQLIIEYLLHCQDCLSASVAQLEARLQTSLGQQQRGQQELGRQADELK-GVREESRRRR 147
LAQ L ++ ++ +A+ Q +L +++ Q E+ +A+ LK V E SR +
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQA 2534
Query: 148 KMISTLQQLLMQTGT--HSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPV 205
+ Q+ Q H L T T ++ +R + + ++ +
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELA--TQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2592
Query: 206 EEVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEF---DKWKEQEWTK 262
E E+L+ + K Q + E + ++++ LQE + + Q + K +++ EQE K
Sbjct: 2593 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2652
Query: 263 LYGEIDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDE------ESEEW 316
L ++LF DE VAK EE+ R Q +L + +E E+EE
Sbjct: 2653 L-------EQLFQDE---VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702
Query: 317 LRQARELQALREKTEIQKTEWKRKVKE--LHEEHMAEKKELQEENQRLQASLSQDQKKAA 374
+R+ +E E+Q+ E +R+ +E L EE+ +++LQ ++ +A+L+ ++ A
Sbjct: 2703 VRRKQE--------ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754
Query: 375 AQ 376
+Q
Sbjct: 2755 SQ 2756
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/511 (21%), Positives = 207/511 (40%), Gaps = 75/511 (14%)
Query: 109 AQLEARLQT--SLGQQQRGQQELGRQADELKGVRE-ESRRRRKMISTL----QQLLMQTG 161
AQ EA+ T +L + RG QE+G + + G R+ E R R+ ++ L Q +L QT
Sbjct: 1274 AQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1333
Query: 162 THSYHTCHLCDKTFMNATFLRGHIQRRHAGVAEGGKQKKQEQPVEEV-LEELRAKLKWTQ 220
++ + R A + + ++++Q Q + + +R +L+ Q
Sbjct: 1334 VRQREL----EQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389
Query: 221 GELEAQREAERQ-RQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEIDKLKKLFWDEFK 279
LE E ER +++E + ++ I A K+++ +L KK
Sbjct: 1390 ALLE---EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK------P 1440
Query: 280 NVAKQNSTLEEKLRALQSHSVMESKLGS---------LRDEESEEWLRQARELQALREKT 330
V + ++ ++ L++H + L S LR E EE L + + +
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1500
Query: 331 EIQKT-EWKRKVKELHEEHMA----EKKELQEENQ-----RLQASLSQDQKKAAAQSQCQ 380
E++ E +R++ E H + A E KELQ+ Q R +A++ Q+K + Q + Q
Sbjct: 1501 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560
Query: 381 ISTLRAQLQEQARIIASQEEMIQSLSLRKVEGIHKVP---KAVDTEEDSPEEEMEDSQDE 437
LR + + + A Q E + LR E I V +A + + E E++ +
Sbjct: 1561 --QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1618
Query: 438 QHKVLAALRRNPTLLKHFRPILEDTLEEKLES---MGIRKDAKG-ISIQTLRHLESL--L 491
+ A R+ + R ++D + K ++ + R A+ + + R L++L L
Sbjct: 1619 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1678
Query: 492 RVQREQKARKF-----------------------SEFLSLRGKLVKEVTSRAKERQENGA 528
R+Q E+ R+ +E S R ++ + QE
Sbjct: 1679 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHV 1738
Query: 529 AVSQPDGQPSVKSQQSALVTREAQPKTRTLQ 559
AV+Q + ++QQ A R + R L+
Sbjct: 1739 AVAQLREEAERRAQQQAEAERAREEAERELE 1769
Score = 52.4 bits (124), Expect = 2e-06
Identities = 96/464 (20%), Positives = 178/464 (38%), Gaps = 51/464 (10%)
Query: 121 QQQRGQQELGRQADELKGVREESRRRRKMISTLQQLLMQTGTHSYHTCHLCDKTFMNATF 180
++QR Q L +EL+ EE+ RR + + +Q + + A+F
Sbjct: 1667 EKQRALQAL----EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 181 ------LRGHIQRRHAGVA----EGGKQKKQEQPVEEVLEELRAKL-KWTQGELEAQR-- 227
L +Q H VA E ++ +Q+ E EE +L +W EA R
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 228 ----EAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGEI-----DKLKKLFWDEF 278
E +Q+ L +AE Q+E ++ + K +E E+ +K ++L
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA---- 1838
Query: 279 KNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQARELQALREKTEIQKTEWK 338
+ A+Q E++L L++ + + L +EE R+A R++ E +
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA--- 1895
Query: 339 RKVKELHEEHMAEKKELQEEN--------QRLQASLSQDQKKA--AAQSQCQISTLRAQL 388
KV+ E +A K +EE+ QRL+A + ++ A AA+ + + Q
Sbjct: 1896 -KVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Query: 389 QEQARIIASQEEMIQSLSLRKVEGIHKVPKAVDTEEDSPEEEMEDSQDEQHKVLAALRRN 448
Q A Q + + K+ I + + + TE + +E E + ++
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATR-LKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 449 PTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLESLLRVQREQKARKFSEFLSL 508
L+ + +EE+L + D++ L + L+ Q+ + E L+L
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSE------LERQKGLVEDTLRQRRQVEEEILAL 2067
Query: 509 RGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTREAQ 552
+ K +A+ E G S + K Q R+ Q
Sbjct: 2068 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111
Score = 43.1 bits (100), Expect = 0.001
Identities = 79/397 (19%), Positives = 147/397 (37%), Gaps = 53/397 (13%)
Query: 207 EVLEELRAKLKWTQGELEAQREAERQRQLQEAELIHQREIEAKKEFDKWKEQEWTKLYGE 266
E L+ + ++ TQG E R E Q + +A E+EA K K KL +
Sbjct: 1223 EKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-------KLRAQ 1275
Query: 267 IDKLKKLFWDEFKNVAKQNSTLEEKLRALQSHSVMESKLGSLRDEESEEWLRQAREL--- 323
+ + F L ++LR Q + RD E E W + +L
Sbjct: 1276 AEAQQPTF-----------DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324
Query: 324 -QALREKTEIQKTEWKRKVKELHEEH---------MAEKKELQEENQRLQASLSQDQKKA 373
QA+ +T++++ E ++ ++L + + + QE+ Q + + SQ ++
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384
Query: 374 AAQSQCQISTLR---AQLQEQARIIASQEEMIQSLSLRKVEGIHKV-PKAVDTEEDSPEE 429
Q Q + + +++E R I+ L+ V ++ P A ++ +
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444
Query: 430 EMEDSQDEQHKVLAALRRNPTLLKHFRPILEDTLEEKLESMGIRKDAKGISIQTLRHLES 489
E E + TL + + +TL E + + + + L +E+
Sbjct: 1445 GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEA 1504
Query: 490 LLRVQREQKARKFSEFLSLRGKLVKEVTSRAKERQENGAAVSQPDGQPSVKSQQSALVTR 549
L QR+ + E ++AK + E A Q Q V ++ A V
Sbjct: 1505 ALEKQRQ----------------LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDA 1548
Query: 550 EAQPKT--RTLQVALPSTPAEPPPPTRQSHGSHGSSL 584
+ Q ++ LQ S+ AE RQ+ + S L
Sbjct: 1549 QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRL 1585
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,543,589
Number of Sequences: 37866
Number of extensions: 1823052
Number of successful extensions: 23425
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 320
Number of HSP's successfully gapped in prelim test: 1767
Number of HSP's that attempted gapping in prelim test: 13224
Number of HSP's gapped (non-prelim): 7760
length of query: 767
length of database: 18,247,518
effective HSP length: 110
effective length of query: 657
effective length of database: 14,082,258
effective search space: 9252043506
effective search space used: 9252043506
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.