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Search of human proteins with 27545313
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|27545313 ubiquitin specific peptidase 38 [Homo sapiens]
(1042 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|27545313 ubiquitin specific peptidase 38 [Homo sapiens] 2082 0.0
gi|148746183 ubiquitin specific protease 35 [Homo sapiens] 576 e-164
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 77 1e-13
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 77 1e-13
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 74 9e-13
gi|71774197 ubiquitin specific protease 47 [Homo sapiens] 72 4e-12
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] 71 6e-12
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 70 1e-11
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 70 1e-11
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 70 1e-11
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 69 2e-11
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 67 7e-11
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 67 7e-11
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 67 7e-11
gi|183396780 ubiquitin specific protease 20 [Homo sapiens] 67 1e-10
gi|183397136 ubiquitin specific protease 20 [Homo sapiens] 67 1e-10
gi|183397134 ubiquitin specific protease 20 [Homo sapiens] 67 1e-10
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 65 3e-10
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 65 3e-10
gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens] 65 4e-10
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 64 6e-10
gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [... 64 7e-10
gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [... 64 7e-10
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 63 1e-09
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 63 1e-09
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 63 1e-09
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 62 2e-09
gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens] 62 3e-09
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] 62 3e-09
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 61 6e-09
>gi|27545313 ubiquitin specific peptidase 38 [Homo sapiens]
Length = 1042
Score = 2082 bits (5394), Expect = 0.0
Identities = 1042/1042 (100%), Positives = 1042/1042 (100%)
Query: 1 MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDLTTRLILEGQDPFQRQV 60
MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDLTTRLILEGQDPFQRQV
Sbjct: 1 MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDLTTRLILEGQDPFQRQV 60
Query: 61 GHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVAILDYIHNGLKLIMSCPSV 120
GHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVAILDYIHNGLKLIMSCPSV
Sbjct: 61 GHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVAILDYIHNGLKLIMSCPSV 120
Query: 121 LDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKGKLSITFCQQLVRTIGHFQC 180
LDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKGKLSITFCQQLVRTIGHFQC
Sbjct: 121 LDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKGKLSITFCQQLVRTIGHFQC 180
Query: 181 VSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFASISSTDASFEPSVALASL 240
VSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFASISSTDASFEPSVALASL
Sbjct: 181 VSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFASISSTDASFEPSVALASL 240
Query: 241 VQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKGLAAV 300
VQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKGLAAV
Sbjct: 241 VQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKGLAAV 300
Query: 301 QKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHLIVPHVVNLVH 360
QKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHLIVPHVVNLVH
Sbjct: 301 QKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHLIVPHVVNLVH 360
Query: 361 SFKNDGLPSSTAFLVQLTELIHCMMYHYSGFPDLYEPILEAIKDFPKPSEEKIKLILNQS 420
SFKNDGLPSSTAFLVQLTELIHCMMYHYSGFPDLYEPILEAIKDFPKPSEEKIKLILNQS
Sbjct: 361 SFKNDGLPSSTAFLVQLTELIHCMMYHYSGFPDLYEPILEAIKDFPKPSEEKIKLILNQS 420
Query: 421 AWTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNG 480
AWTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNG
Sbjct: 421 AWTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNG 480
Query: 481 CNSLMKKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE 540
CNSLMKKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE
Sbjct: 481 CNSLMKKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE 540
Query: 541 KILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRC 600
KILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRC
Sbjct: 541 KILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRC 600
Query: 601 LNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVY 660
LNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVY
Sbjct: 601 LNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVY 660
Query: 661 NPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTD 720
NPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTD
Sbjct: 661 NPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTD 720
Query: 721 LLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKI 780
LLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKI
Sbjct: 721 LLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKI 780
Query: 781 LDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPY 840
LDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPY
Sbjct: 781 LDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPY 840
Query: 841 LLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVF 900
LLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVF
Sbjct: 841 LLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVF 900
Query: 901 EQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQHSTNGLSGNNP 960
EQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQHSTNGLSGNNP
Sbjct: 901 EQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQHSTNGLSGNNP 960
Query: 961 TSGLWINGDPPLQKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGFDDNDPP 1020
TSGLWINGDPPLQKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGFDDNDPP
Sbjct: 961 TSGLWINGDPPLQKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGFDDNDPP 1020
Query: 1021 GSCGPTGGGGGGGFNTVGRLVF 1042
GSCGPTGGGGGGGFNTVGRLVF
Sbjct: 1021 GSCGPTGGGGGGGFNTVGRLVF 1042
>gi|148746183 ubiquitin specific protease 35 [Homo sapiens]
Length = 1018
Score = 576 bits (1484), Expect = e-164
Identities = 308/629 (48%), Positives = 416/629 (66%), Gaps = 34/629 (5%)
Query: 1 MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDLTTRLILEGQDPFQRQV 60
MDKILE +V+SS+P+ +K+ +VR+V+E+A L+ QC A+ L RL + G + R+V
Sbjct: 1 MDKILEAVVTSSYPVSVKQGLVRRVLEAARQPLEREQCLALLALGARLYVGGAEELPRRV 60
Query: 61 GHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVAILDYIHNGLKLIMSCPSV 120
G Q+L R+H F FF+ VL LL G + +A + GL+L+ P+
Sbjct: 61 GCQLLHVAGRHHPDVFAEFFSARRVLRLLQGGAGPPGPRALACVQL---GLQLLPEGPAA 117
Query: 121 LDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKGKLSITFCQQLVRTIGHFQC 180
++F+LL+ EVLR VCERP P CA+++ LL +C+P G + FCQQLVR +G F+C
Sbjct: 118 DEVFALLRREVLRTVCERPGPAACAQVARLLARHPRCVPDGPHRLLFCQQLVRCLGRFRC 177
Query: 181 VSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFASISSTDASFEPSVALASL 240
+ E E++ Q +VS LL +W+A+PA +LP L+E+FA IS + PS ALAS+
Sbjct: 178 PAEGEEGAVEFLEQAQQVSGLLAQLWRAQPAAILPCLKELFAVISCAEEE-PPSSALASV 236
Query: 241 VQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKGLAAV 300
VQH+PL+++ ++R+L+ D +V D+ M A+ RMIDW+SWPL +++D W+IALLKGLAAV
Sbjct: 237 VQHLPLELMDGVVRNLSNDDSVTDSQMLTAISRMIDWVSWPLGKNIDKWIIALLKGLAAV 296
Query: 301 QKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHLIVPHVVNLVH 360
+KF+ILI+V+L KIE VF++L +P+VR AL+VL +MLL+FQHS EAFHL++PH+ +V
Sbjct: 297 KKFSILIEVSLTKIEKVFSKLLYPIVRGAALSVLKYMLLTFQHSHEAFHLLLPHIPPMVA 356
Query: 361 SFKNDGLPSSTAFLVQLTELIHCMMYHYSGFPDLYEPILEAIKDFPKPSEEKIKLILNQS 420
S + S T+ L QL EL+HCM++ + GFPDLYEP++EAIKD P+E++IK +L Q
Sbjct: 357 SLVKEDSNSGTSCLEQLAELVHCMVFRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQD 416
Query: 421 AWTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNG 480
AWTSQ + LA RL KS+TGK GLINLGNTCY+NS++QALFMA+DFR VL L N
Sbjct: 417 AWTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYVNSILQALFMASDFRHCVLRLTENN 476
Query: 481 CNSLMKKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE 540
LM KLQ LF FL H+QR A +P F AS PWF+P +QQDCSEYL++LLDRLHEEE
Sbjct: 477 SQPLMTKLQWLFGFLEHSQRPAISPENFLSASWTPWFSPGTQQDCSEYLKYLLDRLHEEE 536
Query: 541 KI-------LKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGK 593
K LK +S P E E P S T +EKMFGGK
Sbjct: 537 KTGTRICQKLKQSSSPSPPE--------------------EPPAPS---STSVEKMFGGK 573
Query: 594 LRTHIRCLNCRSTSQKVEAFTDLSLAFCP 622
+ T I CL C + S + EAFTDLSLAF P
Sbjct: 574 IVTRICCLCCLNVSSREEAFTDLSLAFPP 602
Score = 218 bits (555), Expect = 2e-56
Identities = 137/327 (41%), Positives = 178/327 (54%), Gaps = 75/327 (22%)
Query: 711 GGETTPSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSY 770
G E + SV DL+NYFL+PE LT +N+YYCE+CASLQ+AEK +++++ P YLILTLLRFS+
Sbjct: 754 GSEGSRSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEKVVELSQGPCYLILTLLRFSF 813
Query: 771 DQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTD 830
D + RRKILD+VS+PL+L LP+ G
Sbjct: 814 DLRTMRRRKILDDVSIPLLLRLPLA-------------------------------GGRG 842
Query: 831 EASCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHL 890
+A Y L SVVVHSG+SSESGHYY YAR
Sbjct: 843 QA-------YDLCSVVVHSGVSSESGHYYCYARE-------------------------- 869
Query: 891 LGRDSPSAVFEQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQH 950
G P+A + E +W+LFND+RV+F+SF+SV +TS FPKDTAYVL Y +Q
Sbjct: 870 -GAARPAASLGT-ADRPEPENQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFY-RQR 926
Query: 951 STNGLSGNNPTSGLWINGDPPLQKELMDAITKDNKLYLQEQELNARARALQAASASCS-- 1008
G +S + +P L K+LM+AI+KDN LYLQEQE AR+RA ++ S
Sbjct: 927 PREGPEAELGSSR--VRTEPTLHKDLMEAISKDNILYLQEQEKEARSRAAYISALPTSPH 984
Query: 1009 ----FRPNGFDDNDPPGSCGPTGGGGG 1031
F + +D PG C P GG GG
Sbjct: 985 WGRGFDEDKDEDEGSPGGCNPAGGNGG 1011
>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
sapiens]
Length = 359
Score = 76.6 bits (187), Expect = 1e-13
Identities = 60/183 (32%), Positives = 83/183 (45%), Gaps = 28/183 (15%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRRQVLSLNL--NGCNSLMKKLQHLFAFLAHTQRE-- 501
GL+N GNTCY NSV+QAL+ FR VL+ +L+ L LF +A +++
Sbjct: 29 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVG 88
Query: 502 AYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLL----DRLHEEEKILKVQASHKPSEIL 555
P+ F R F QQD E+L +LL D L EE+K K K +
Sbjct: 89 VIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMN 148
Query: 556 ECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTD 615
E +E + E+ T + ++F G L RCLNC + S K E F D
Sbjct: 149 EPAENNKPEL------------------TWVHEIFQGTLTNETRCLNCETVSSKDEDFLD 190
Query: 616 LSL 618
LS+
Sbjct: 191 LSV 193
Score = 61.6 bits (148), Expect = 4e-09
Identities = 54/193 (27%), Positives = 81/193 (41%), Gaps = 41/193 (21%)
Query: 673 VNEKTIGSPPNEFYCSENTSVPNESNKIL-VNKDVPQKPGGETTPSVTDLLNYFLAPEIL 731
V+E G+ NE C +V ++ L ++ DV Q S+T L F E L
Sbjct: 161 VHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNT------SITHCLRDFSNTETL 214
Query: 732 TGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLE 791
+ +YYCE C S Q A+K M++ + P L L L RF Y ++ H K+ V PL L
Sbjct: 215 CSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELR 274
Query: 792 LPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSGI 851
L F++ S++ ++D Y L +VVVH G
Sbjct: 275 L-------FNTSSDAVNLD---------------------------RMYDLVAVVVHCGS 300
Query: 852 SSESGHYYSYARN 864
GHY + ++
Sbjct: 301 GPNRGHYITIVKS 313
>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
sapiens]
Length = 366
Score = 76.6 bits (187), Expect = 1e-13
Identities = 60/183 (32%), Positives = 83/183 (45%), Gaps = 28/183 (15%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRRQVLSLNL--NGCNSLMKKLQHLFAFLAHTQRE-- 501
GL+N GNTCY NSV+QAL+ FR VL+ +L+ L LF +A +++
Sbjct: 36 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLADLFHSIATQKKKVG 95
Query: 502 AYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLL----DRLHEEEKILKVQASHKPSEIL 555
P+ F R F QQD E+L +LL D L EE+K K K +
Sbjct: 96 VIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKNGNMN 155
Query: 556 ECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTD 615
E +E + E+ T + ++F G L RCLNC + S K E F D
Sbjct: 156 EPAENNKPEL------------------TWVHEIFQGTLTNETRCLNCETVSSKDEDFLD 197
Query: 616 LSL 618
LS+
Sbjct: 198 LSV 200
Score = 61.6 bits (148), Expect = 4e-09
Identities = 54/193 (27%), Positives = 81/193 (41%), Gaps = 41/193 (21%)
Query: 673 VNEKTIGSPPNEFYCSENTSVPNESNKIL-VNKDVPQKPGGETTPSVTDLLNYFLAPEIL 731
V+E G+ NE C +V ++ L ++ DV Q S+T L F E L
Sbjct: 168 VHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVEQNT------SITHCLRDFSNTETL 221
Query: 732 TGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLE 791
+ +YYCE C S Q A+K M++ + P L L L RF Y ++ H K+ V PL L
Sbjct: 222 CSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKYMEQLHRYTKLSYRVVFPLELR 281
Query: 792 LPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSGI 851
L F++ S++ ++D Y L +VVVH G
Sbjct: 282 L-------FNTSSDAVNLD---------------------------RMYDLVAVVVHCGS 307
Query: 852 SSESGHYYSYARN 864
GHY + ++
Sbjct: 308 GPNRGHYITIVKS 320
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 73.6 bits (179), Expect = 9e-13
Identities = 63/220 (28%), Positives = 102/220 (46%), Gaps = 41/220 (18%)
Query: 425 QSNSLASCLSRLSGKSET-GKTGLINLGNTCYMNSVIQALFMATDF-------------- 469
++++L S L +++G + TGL NLGNTC+MN+++Q+L F
Sbjct: 138 ENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRN 197
Query: 470 ----RRQVLSLNLNGCN--SLMKKLQHLFAFLAHTQREAYAPRIFFEA--SRPPWFTPRS 521
R+ G N SL+++ + L + A++P F P F
Sbjct: 198 GKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQ 257
Query: 522 QQDCSEYLRFLLDRLHEEEKILKVQASHKP---SEILECSETSLQEVASKAAVLTETPRT 578
QQD E++R+LLD LH L++Q S IL+ E S ++K +
Sbjct: 258 QQDAHEFMRYLLDHLH-----LELQGGFNGVSRSAILQ--ENSTLSASNKCCI------- 303
Query: 579 SDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSL 618
+G T++ +FGG L+ + CL C + S+K + F DLSL
Sbjct: 304 -NGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSL 342
Score = 44.7 bits (104), Expect = 5e-04
Identities = 58/238 (24%), Positives = 78/238 (32%), Gaps = 84/238 (35%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHV 776
S+ D L F E L Y C C Q + K I + P+ L L L RF + ++
Sbjct: 363 SLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YL 420
Query: 777 RRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTK 836
R K+ V PL L +K L+P + SC
Sbjct: 421 RNKVDTYVEFPL-RGLDMK-------------------------CYLLEPENSGPESCL- 453
Query: 837 LVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSP 896
Y L++VVVH G SGHY +YA +
Sbjct: 454 ---YDLAAVVVHHGSGVGSGHYTAYATH-------------------------------- 478
Query: 897 SAVFEQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQHSTNG 954
WF FNDS VT T ++V K AY+L Y + + G
Sbjct: 479 -------------EGRWFHFNDSTVTLTDEETVVKA-------KAYILFYVEHQAKAG 516
>gi|71774197 ubiquitin specific protease 47 [Homo sapiens]
Length = 1287
Score = 71.6 bits (174), Expect = 4e-12
Identities = 62/237 (26%), Positives = 95/237 (40%), Gaps = 58/237 (24%)
Query: 420 SAWTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNL- 478
S + SQS S +S L+ KSETG GL+N TCY+NS++Q LFM +FR +
Sbjct: 79 SDYVSQSYSYSSILN----KSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFE 134
Query: 479 ----NGCNSLMKKLQHLFAFLAHTQREAY----APRIFFEASRPPWFTPRSQQDCSEYLR 530
+ S+ +LQ LF L +++ A R F S W Q D E R
Sbjct: 135 ESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAW----QQHDVQELCR 190
Query: 531 FLLDRLHEEEKILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMF 590
+ D L ++ K + LI +++
Sbjct: 191 VMFDALEQKWK-------------------------------------QTEQADLINELY 213
Query: 591 GGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPA----SSPSIQDG 643
GKL+ ++RCL C +++ + D+ L P S + + + A P I DG
Sbjct: 214 QGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDG 270
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/173 (30%), Positives = 86/173 (49%), Gaps = 25/173 (14%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHV 776
SV + L+ F+ PEIL G NQY+CE C +A K ++ P L L L RF +D
Sbjct: 254 SVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMH 313
Query: 777 RRKILDNVSLPLVLELPV------KRITSFSSLSESWS----------VDVDFTD---LS 817
R K+ D ++ P L++ ++ S ++S + + DF++ +
Sbjct: 314 RIKLNDRMTFPEELDMSTFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDDGVD 373
Query: 818 ENLAKKLKPSGTDEASCTKL----VPYLLSSVVVHSGISSESGHYYSYARNIT 866
E + + SGT++ S + L + Y L SV+VHSG S+ GHYY+ ++ +
Sbjct: 374 EGICLETN-SGTEKISKSGLEKNSLIYELFSVMVHSG-SAAGGHYYACIKSFS 424
>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
Length = 370
Score = 70.9 bits (172), Expect = 6e-12
Identities = 55/182 (30%), Positives = 84/182 (46%), Gaps = 26/182 (14%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRRQVLSLNL--NGCNSLMKKLQHLFAFLAHTQRE-- 501
GL+N GNTCY NSV+QAL+ FR +VL+ SL+ L LF +A +++
Sbjct: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVG 99
Query: 502 AYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLLDRLH---EEEKILKVQASHKPSEILE 556
P+ F R F QQD E+L +LL+ + +EE+ + Q P+ ++
Sbjct: 100 VIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNID 159
Query: 557 CSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDL 616
+ S + T ++++F G L RCL C + S K E F DL
Sbjct: 160 NENNN-----------------STPDPTWVDEIFQGTLTNETRCLTCETISSKDEDFLDL 202
Query: 617 SL 618
S+
Sbjct: 203 SV 204
Score = 55.8 bits (133), Expect = 2e-07
Identities = 52/193 (26%), Positives = 77/193 (39%), Gaps = 41/193 (21%)
Query: 673 VNEKTIGSPPNEFYCSENTSVPNESNKIL-VNKDVPQKPGGETTPSVTDLLNYFLAPEIL 731
V+E G+ NE C ++ ++ L ++ DV Q S+T L F E L
Sbjct: 172 VDEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNT------SITHCLRGFSNTETL 225
Query: 732 TGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLE 791
+ +YYCE C S Q A K M++ + P L L L RF Y + H K+ V PL L
Sbjct: 226 CSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELR 285
Query: 792 LPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSGI 851
L F++ ++ + D Y L +VVVH G
Sbjct: 286 L-------FNTSGDATNPD---------------------------RMYDLVAVVVHCGS 311
Query: 852 SSESGHYYSYARN 864
GHY + ++
Sbjct: 312 GPNRGHYIAIVKS 324
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 70.1 bits (170), Expect = 1e-11
Identities = 55/194 (28%), Positives = 87/194 (44%), Gaps = 19/194 (9%)
Query: 436 LSGKSETGKTGLINLGNTCYMNSVIQALFMATDFR----RQVLSLNLNGCNSLMKKLQHL 491
++ KS G GL NLGNTC+MNS++Q L + R +++ +L+ ++ L
Sbjct: 258 MNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEE 317
Query: 492 FAFLAHT-----QREAYAPRIFFEASR--PPWFTPRSQQDCSEYLRFLLDRLHEEEKILK 544
FA L T + +P F + P F +QQD E+LRFLLD LH E +
Sbjct: 318 FAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVT 377
Query: 545 VQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCR 604
++ P + + + + E R D +F G+L++ + C +C
Sbjct: 378 LRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGD--------LFVGQLKSSLTCTDCG 429
Query: 605 STSQKVEAFTDLSL 618
S + F DLSL
Sbjct: 430 YCSTVFDPFWDLSL 443
Score = 35.8 bits (81), Expect = 0.22
Identities = 42/175 (24%), Positives = 66/175 (37%), Gaps = 43/175 (24%)
Query: 716 PSVT--DLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQK 773
P VT D + F ++L GD + C C + K I P+ L+L L RFS +
Sbjct: 451 PEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESR- 509
Query: 774 YHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDL-SENLAKKLKPSGTDEA 832
+ L + P++ D+D + SEN
Sbjct: 510 -------IRTSKLTTFVNFPLR--------------DLDLREFASEN------------- 535
Query: 833 SCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQ 887
T Y L +V HSG ++ GHY +Y R + + ++ S ++SSQ
Sbjct: 536 --TNHAVYNLYAVSNHSG-TTMGGHYTAYCR--SPGTGEWHTFNDSSVTPMSSSQ 585
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 69.7 bits (169), Expect = 1e-11
Identities = 76/284 (26%), Positives = 114/284 (40%), Gaps = 77/284 (27%)
Query: 583 KTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQD 642
+++I +F G + + ++CL C S +E F DLSL P E+++ +S P+
Sbjct: 472 RSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSL---PIPGKEDLAKLHSSSHPT--- 525
Query: 643 GGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILV 702
+++A G + P + AF + V + P+ F+
Sbjct: 526 -SIVKAGSCGEAYAPQGW----IAFFME-YVKRFVVSCVPSWFW---------------- 563
Query: 703 NKDVPQKPGGETTPSVT--DLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEY 760
P VT D L F A + L GDN Y CE C L+N K ++ PE
Sbjct: 564 ------------GPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEI 611
Query: 761 LILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENL 820
L + L RF ++ + KI +VS PL + DL L
Sbjct: 612 LCIHLKRFRHELMFST--KISTHVSFPL-----------------------EGLDLQPFL 646
Query: 821 AKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESGHYYSYARN 864
AK S ++V Y L SV+ H G +S SGHY +Y RN
Sbjct: 647 AKD---------SPAQIVTYDLLSVICHHGTAS-SGHYIAYCRN 680
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/136 (33%), Positives = 65/136 (47%), Gaps = 9/136 (6%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLS----LNLNGCNSLMKKLQHLFAFLAHT 498
G TGL N+GNTCYMN+ +QAL + L + ++ K L L H
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK 242
Query: 499 QRE-AYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEIL 555
R + P F+ + P F SQQD E+LR L+D LHEE K ++ P I
Sbjct: 243 SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTI- 301
Query: 556 ECSETSLQEVASKAAV 571
+E +++E S++ V
Sbjct: 302 -TTEETMEEDKSQSDV 316
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 69.7 bits (169), Expect = 1e-11
Identities = 76/284 (26%), Positives = 114/284 (40%), Gaps = 77/284 (27%)
Query: 583 KTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQD 642
+++I +F G + + ++CL C S +E F DLSL P E+++ +S P+
Sbjct: 441 RSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSL---PIPGKEDLAKLHSSSHPT--- 494
Query: 643 GGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILV 702
+++A G + P + AF + V + P+ F+
Sbjct: 495 -SIVKAGSCGEAYAPQGW----IAFFME-YVKRFVVSCVPSWFW---------------- 532
Query: 703 NKDVPQKPGGETTPSVT--DLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEY 760
P VT D L F A + L GDN Y CE C L+N K ++ PE
Sbjct: 533 ------------GPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEI 580
Query: 761 LILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENL 820
L + L RF ++ + KI +VS PL + DL L
Sbjct: 581 LCIHLKRFRHELMFST--KISTHVSFPL-----------------------EGLDLQPFL 615
Query: 821 AKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESGHYYSYARN 864
AK S ++V Y L SV+ H G +S SGHY +Y RN
Sbjct: 616 AKD---------SPAQIVTYDLLSVICHHGTAS-SGHYIAYCRN 649
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/136 (33%), Positives = 65/136 (47%), Gaps = 9/136 (6%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLS----LNLNGCNSLMKKLQHLFAFLAHT 498
G TGL N+GNTCYMN+ +QAL + L + ++ K L L H
Sbjct: 152 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK 211
Query: 499 QRE-AYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEIL 555
R + P F+ + P F SQQD E+LR L+D LHEE K ++ P I
Sbjct: 212 SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTI- 270
Query: 556 ECSETSLQEVASKAAV 571
+E +++E S++ V
Sbjct: 271 -TTEETMEEDKSQSDV 285
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 69.3 bits (168), Expect = 2e-11
Identities = 55/193 (28%), Positives = 86/193 (44%), Gaps = 19/193 (9%)
Query: 437 SGKSETGKTGLINLGNTCYMNSVIQALFMATDFR----RQVLSLNLNGCNSLMKKLQHLF 492
+ KS G GL NLGNTC+MNS++Q L + R +++ +L+ ++ L F
Sbjct: 50 NSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEF 109
Query: 493 AFLAHT-----QREAYAPRIFFEASR--PPWFTPRSQQDCSEYLRFLLDRLHEEEKILKV 545
A L T + +P F + P F +QQD E+LRFLLD LH E + +
Sbjct: 110 AKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTL 169
Query: 546 QASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRS 605
+ P + + + + E R D +F G+L++ + C +C
Sbjct: 170 RPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGD--------LFVGQLKSSLTCTDCGY 221
Query: 606 TSQKVEAFTDLSL 618
S + F DLSL
Sbjct: 222 CSTVFDPFWDLSL 234
Score = 35.8 bits (81), Expect = 0.22
Identities = 42/175 (24%), Positives = 66/175 (37%), Gaps = 43/175 (24%)
Query: 716 PSVT--DLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQK 773
P VT D + F ++L GD + C C + K I P+ L+L L RFS +
Sbjct: 242 PEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESR- 300
Query: 774 YHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDL-SENLAKKLKPSGTDEA 832
+ L + P++ D+D + SEN
Sbjct: 301 -------IRTSKLTTFVNFPLR--------------DLDLREFASEN------------- 326
Query: 833 SCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQ 887
T Y L +V HSG ++ GHY +Y R + + ++ S ++SSQ
Sbjct: 327 --TNHAVYNLYAVSNHSG-TTMGGHYTAYCR--SPGTGEWHTFNDSSVTPMSSSQ 376
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 67.4 bits (163), Expect = 7e-11
Identities = 66/214 (30%), Positives = 93/214 (43%), Gaps = 25/214 (11%)
Query: 433 LSRLSGKSETGKTGLINLGNTCYMNSVIQAL----FMATDFRRQVLSLNLNGCNSLMKKL 488
L+ + G S TGL NLGNTCYMNS++Q L +A F R ++N N L K
Sbjct: 765 LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824
Query: 489 QHLFAF------LAHTQREAYAPRIF--FEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE 540
+ F L Q +P+ F F SQQD E L FL+D LHE+
Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884
Query: 541 KILKVQASHKPSEILECSETSLQEVA-SKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIR 599
+ +K + E A K L E ++I +F G+ ++ ++
Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNE---------SIIVALFQGQFKSTVQ 935
Query: 600 CLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQD 633
CL C S+ EAF LSL P +S ++QD
Sbjct: 936 CLTCHKKSRTFEAFMYLSL---PLASTSKCTLQD 966
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/72 (33%), Positives = 45/72 (62%), Gaps = 2/72 (2%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHV 776
++ D L F E LT +N++YC +C + +++ K ++I + P L++ L RFSYD ++
Sbjct: 963 TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW-- 1020
Query: 777 RRKILDNVSLPL 788
++K+ +V PL
Sbjct: 1021 KQKLQTSVDFPL 1032
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 67.4 bits (163), Expect = 7e-11
Identities = 66/214 (30%), Positives = 93/214 (43%), Gaps = 25/214 (11%)
Query: 433 LSRLSGKSETGKTGLINLGNTCYMNSVIQAL----FMATDFRRQVLSLNLNGCNSLMKKL 488
L+ + G S TGL NLGNTCYMNS++Q L +A F R ++N N L K
Sbjct: 765 LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824
Query: 489 QHLFAF------LAHTQREAYAPRIF--FEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE 540
+ F L Q +P+ F F SQQD E L FL+D LHE+
Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884
Query: 541 KILKVQASHKPSEILECSETSLQEVA-SKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIR 599
+ +K + E A K L E ++I +F G+ ++ ++
Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNE---------SIIVALFQGQFKSTVQ 935
Query: 600 CLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQD 633
CL C S+ EAF LSL P +S ++QD
Sbjct: 936 CLTCHKKSRTFEAFMYLSL---PLASTSKCTLQD 966
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/72 (33%), Positives = 45/72 (62%), Gaps = 2/72 (2%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHV 776
++ D L F E LT +N++YC +C + +++ K ++I + P L++ L RFSYD ++
Sbjct: 963 TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW-- 1020
Query: 777 RRKILDNVSLPL 788
++K+ +V PL
Sbjct: 1021 KQKLQTSVDFPL 1032
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 67.4 bits (163), Expect = 7e-11
Identities = 66/214 (30%), Positives = 93/214 (43%), Gaps = 25/214 (11%)
Query: 433 LSRLSGKSETGKTGLINLGNTCYMNSVIQAL----FMATDFRRQVLSLNLNGCNSLMKKL 488
L+ + G S TGL NLGNTCYMNS++Q L +A F R ++N N L K
Sbjct: 765 LNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKG 824
Query: 489 QHLFAF------LAHTQREAYAPRIF--FEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE 540
+ F L Q +P+ F F SQQD E L FL+D LHE+
Sbjct: 825 EVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDL 884
Query: 541 KILKVQASHKPSEILECSETSLQEVA-SKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIR 599
+ +K + E A K L E ++I +F G+ ++ ++
Sbjct: 885 NKADNRKRYKEENNDHLDDFKAAEHAWQKHKQLNE---------SIIVALFQGQFKSTVQ 935
Query: 600 CLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQD 633
CL C S+ EAF LSL P +S ++QD
Sbjct: 936 CLTCHKKSRTFEAFMYLSL---PLASTSKCTLQD 966
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/72 (33%), Positives = 45/72 (62%), Gaps = 2/72 (2%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHV 776
++ D L F E LT +N++YC +C + +++ K ++I + P L++ L RFSYD ++
Sbjct: 963 TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW-- 1020
Query: 777 RRKILDNVSLPL 788
++K+ +V PL
Sbjct: 1021 KQKLQTSVDFPL 1032
>gi|183396780 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 66.6 bits (161), Expect = 1e-10
Identities = 78/306 (25%), Positives = 118/306 (38%), Gaps = 81/306 (26%)
Query: 565 VASKAAVLTETPRTSDGEK--TLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCP 622
V KA VL+ R ++ ++I +F G + + ++CL C S VE F DLSL P
Sbjct: 422 VLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSL---P 478
Query: 623 SSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPP 682
E+++ A ++ + PG + A + + + P
Sbjct: 479 IPGKEDLAKLHSAIYQNVP-------AKPGACGDSYAAQGWLAFIV--EYIRRFVVSCTP 529
Query: 683 NEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVT--DLLNYFLAPEILTGDNQYYCE 740
+ F+ P VT D L F A + L GDN Y CE
Sbjct: 530 SWFW----------------------------GPVVTLEDCLAAFFAADELKGDNMYSCE 561
Query: 741 NCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSF 800
C L+N K ++ PE L + L RF ++ Y KI +VS PL
Sbjct: 562 RCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF--KINSHVSFPL------------ 607
Query: 801 SSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCT-KLVPYLLSSVVVHSGISSESGHYY 859
+ DL LAK+ CT ++ Y L SV+ H G ++ SGHY
Sbjct: 608 -----------EGLDLRPFLAKE----------CTSQITTYDLLSVICHHG-TAGSGHYI 645
Query: 860 SYARNI 865
+Y +N+
Sbjct: 646 AYCQNV 651
Score = 58.2 bits (139), Expect = 4e-08
Identities = 54/176 (30%), Positives = 77/176 (43%), Gaps = 31/176 (17%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLS----LNLNGCNSLMKKLQHLFAFLAHT 498
G TG+ NLGN+CYMN+ +QAL + L + + +L K Q L + + H
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSEVWHK 202
Query: 499 QREAY-APRIFFEASR--PPWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEIL 555
+R +Y P + P F +QQD E+LR L+D+LHEE
Sbjct: 203 KRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEE---------------- 246
Query: 556 ECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVE 611
L+E LTE R SD T EK G + + L+C S+S + E
Sbjct: 247 ------LKEPVVATVALTEA-RDSDSSDT-DEKREGDRSPSEDEFLSCDSSSDRGE 294
>gi|183397136 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 66.6 bits (161), Expect = 1e-10
Identities = 78/306 (25%), Positives = 118/306 (38%), Gaps = 81/306 (26%)
Query: 565 VASKAAVLTETPRTSDGEK--TLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCP 622
V KA VL+ R ++ ++I +F G + + ++CL C S VE F DLSL P
Sbjct: 422 VLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSL---P 478
Query: 623 SSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPP 682
E+++ A ++ + PG + A + + + P
Sbjct: 479 IPGKEDLAKLHSAIYQNVP-------AKPGACGDSYAAQGWLAFIV--EYIRRFVVSCTP 529
Query: 683 NEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVT--DLLNYFLAPEILTGDNQYYCE 740
+ F+ P VT D L F A + L GDN Y CE
Sbjct: 530 SWFW----------------------------GPVVTLEDCLAAFFAADELKGDNMYSCE 561
Query: 741 NCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSF 800
C L+N K ++ PE L + L RF ++ Y KI +VS PL
Sbjct: 562 RCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF--KINSHVSFPL------------ 607
Query: 801 SSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCT-KLVPYLLSSVVVHSGISSESGHYY 859
+ DL LAK+ CT ++ Y L SV+ H G ++ SGHY
Sbjct: 608 -----------EGLDLRPFLAKE----------CTSQITTYDLLSVICHHG-TAGSGHYI 645
Query: 860 SYARNI 865
+Y +N+
Sbjct: 646 AYCQNV 651
Score = 58.2 bits (139), Expect = 4e-08
Identities = 54/176 (30%), Positives = 77/176 (43%), Gaps = 31/176 (17%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLS----LNLNGCNSLMKKLQHLFAFLAHT 498
G TG+ NLGN+CYMN+ +QAL + L + + +L K Q L + + H
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSEVWHK 202
Query: 499 QREAY-APRIFFEASR--PPWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEIL 555
+R +Y P + P F +QQD E+LR L+D+LHEE
Sbjct: 203 KRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEE---------------- 246
Query: 556 ECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVE 611
L+E LTE R SD T EK G + + L+C S+S + E
Sbjct: 247 ------LKEPVVATVALTEA-RDSDSSDT-DEKREGDRSPSEDEFLSCDSSSDRGE 294
>gi|183397134 ubiquitin specific protease 20 [Homo sapiens]
Length = 914
Score = 66.6 bits (161), Expect = 1e-10
Identities = 78/306 (25%), Positives = 118/306 (38%), Gaps = 81/306 (26%)
Query: 565 VASKAAVLTETPRTSDGEK--TLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCP 622
V KA VL+ R ++ ++I +F G + + ++CL C S VE F DLSL P
Sbjct: 422 VLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSL---P 478
Query: 623 SSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSPP 682
E+++ A ++ + PG + A + + + P
Sbjct: 479 IPGKEDLAKLHSAIYQNVP-------AKPGACGDSYAAQGWLAFIV--EYIRRFVVSCTP 529
Query: 683 NEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVT--DLLNYFLAPEILTGDNQYYCE 740
+ F+ P VT D L F A + L GDN Y CE
Sbjct: 530 SWFW----------------------------GPVVTLEDCLAAFFAADELKGDNMYSCE 561
Query: 741 NCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSF 800
C L+N K ++ PE L + L RF ++ Y KI +VS PL
Sbjct: 562 RCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYSF--KINSHVSFPL------------ 607
Query: 801 SSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCT-KLVPYLLSSVVVHSGISSESGHYY 859
+ DL LAK+ CT ++ Y L SV+ H G ++ SGHY
Sbjct: 608 -----------EGLDLRPFLAKE----------CTSQITTYDLLSVICHHG-TAGSGHYI 645
Query: 860 SYARNI 865
+Y +N+
Sbjct: 646 AYCQNV 651
Score = 58.2 bits (139), Expect = 4e-08
Identities = 54/176 (30%), Positives = 77/176 (43%), Gaps = 31/176 (17%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLS----LNLNGCNSLMKKLQHLFAFLAHT 498
G TG+ NLGN+CYMN+ +QAL + L + + +L K Q L + + H
Sbjct: 143 GLTGMKNLGNSCYMNAALQALSNCPPLTQFFLECGGLVRTDKKPALCKSYQKLVSEVWHK 202
Query: 499 QREAY-APRIFFEASR--PPWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEIL 555
+R +Y P + P F +QQD E+LR L+D+LHEE
Sbjct: 203 KRPSYVVPTSLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEE---------------- 246
Query: 556 ECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCLNCRSTSQKVE 611
L+E LTE R SD T EK G + + L+C S+S + E
Sbjct: 247 ------LKEPVVATVALTEA-RDSDSSDT-DEKREGDRSPSEDEFLSCDSSSDRGE 294
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 65.5 bits (158), Expect = 3e-10
Identities = 71/254 (27%), Positives = 107/254 (42%), Gaps = 38/254 (14%)
Query: 390 GFPDLYEPILEAIKDFPKPSEEKIKLILNQSAWTSQSNSLASCLSRLSGKSETGKTGLIN 449
GFP P L +I+ P S +I +S+ S+ + + L G +G GL N
Sbjct: 162 GFPG--PPTLFSIRTEPPASHGSFHMISARSSEPFYSDDKMAHHTLLLG---SGHVGLRN 216
Query: 450 LGNTCYMNSVIQAL---------FMATDFRRQVLSLNLNGCNSLMKKLQHLFAFLAHTQR 500
LGNTC++N+V+Q L + DFR++V L + + L H
Sbjct: 217 LGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV--PGGGRAQELTEAFADVIGALWHPDS 274
Query: 501 -EAYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEILEC 557
EA P F + P F+ SQQD E+L+ L++RLH E + + IL
Sbjct: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEIN----RRGRRAPPIL-- 328
Query: 558 SETSLQEVASKAAVLTETPRTSDG-------------EKTLIEKMFGGKLRTHIRCLNCR 604
+ + + L E P SD E + I +F G+L++ ++C C
Sbjct: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
Query: 605 STSQKVEAFTDLSL 618
S E F DLSL
Sbjct: 389 YRSTTFEVFCDLSL 402
Score = 35.4 bits (80), Expect = 0.28
Identities = 19/64 (29%), Positives = 28/64 (43%)
Query: 706 VPQKPGGETTPSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTL 765
+P+K S+ D N F E L +N C+ C + K + + P L+L L
Sbjct: 404 IPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHL 463
Query: 766 LRFS 769
RFS
Sbjct: 464 NRFS 467
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 65.5 bits (158), Expect = 3e-10
Identities = 71/254 (27%), Positives = 107/254 (42%), Gaps = 38/254 (14%)
Query: 390 GFPDLYEPILEAIKDFPKPSEEKIKLILNQSAWTSQSNSLASCLSRLSGKSETGKTGLIN 449
GFP P L +I+ P S +I +S+ S+ + + L G +G GL N
Sbjct: 162 GFPG--PPTLFSIRTEPPASHGSFHMISARSSEPFYSDDKMAHHTLLLG---SGHVGLRN 216
Query: 450 LGNTCYMNSVIQAL---------FMATDFRRQVLSLNLNGCNSLMKKLQHLFAFLAHTQR 500
LGNTC++N+V+Q L + DFR++V L + + L H
Sbjct: 217 LGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEV--PGGGRAQELTEAFADVIGALWHPDS 274
Query: 501 -EAYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEILEC 557
EA P F + P F+ SQQD E+L+ L++RLH E + + IL
Sbjct: 275 CEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEIN----RRGRRAPPIL-- 328
Query: 558 SETSLQEVASKAAVLTETPRTSDG-------------EKTLIEKMFGGKLRTHIRCLNCR 604
+ + + L E P SD E + I +F G+L++ ++C C
Sbjct: 329 ANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACG 388
Query: 605 STSQKVEAFTDLSL 618
S E F DLSL
Sbjct: 389 YRSTTFEVFCDLSL 402
Score = 35.4 bits (80), Expect = 0.28
Identities = 19/64 (29%), Positives = 28/64 (43%)
Query: 706 VPQKPGGETTPSVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTL 765
+P+K S+ D N F E L +N C+ C + K + + P L+L L
Sbjct: 404 IPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHL 463
Query: 766 LRFS 769
RFS
Sbjct: 464 NRFS 467
>gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens]
Length = 2555
Score = 64.7 bits (156), Expect = 4e-10
Identities = 50/191 (26%), Positives = 82/191 (42%), Gaps = 24/191 (12%)
Query: 671 SLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTDLLNYFLAPEI 730
S ++K P+ + C E+ + +N D+ ++ D L ++ ++
Sbjct: 1719 SFADQKICQGCPHRYECEESFTT--------LNVDI------RNHQNLLDSLEQYIKGDL 1764
Query: 731 LTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVL 790
L G N Y+CE C + K + I + P L + L RF YD + K D P L
Sbjct: 1765 LEGANAYHCEKCDKKVDTVKRLLIKKLPRVLAIQLKRFDYDWERECAIKFNDYFEFPREL 1824
Query: 791 ELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSG 850
++ + ++L D + L ++ + S + A TK Y L V+VHSG
Sbjct: 1825 DMGPYTVAGVANLER------DNVNSENELIEQKEQSDNETAGGTK---YRLVGVLVHSG 1875
Query: 851 ISSESGHYYSY 861
+S GHYYSY
Sbjct: 1876 QAS-GGHYYSY 1885
Score = 48.9 bits (115), Expect = 2e-05
Identities = 42/151 (27%), Positives = 57/151 (37%), Gaps = 51/151 (33%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCN-------------------- 482
G GL N G TCYMNSVIQ L+M R +L++ G +
Sbjct: 1557 GFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSESNVDPR 1616
Query: 483 ---------------------------SLMKKLQHLFAFLAHTQREAYAPRIFFEASRPP 515
+++ LQ +F LA +Q + Y PR F++ R
Sbjct: 1617 DDVFGYPHQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASQLQYYVPRGFWKQFR-L 1675
Query: 516 WFTP---RSQQDCSEYLRFLLDRLHEEEKIL 543
W P R Q D E+ L+D L E K L
Sbjct: 1676 WGEPVNLREQHDALEFFNSLVDSLDEALKAL 1706
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 64.3 bits (155), Expect = 6e-10
Identities = 63/216 (29%), Positives = 98/216 (45%), Gaps = 30/216 (13%)
Query: 421 AWTSQSNSLA--SCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLS--- 475
+W + + +A S + R +E G TGL NLGNTC+MNS IQ + + +S
Sbjct: 708 SWPEEMSFIANSSKIDRHKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRH 767
Query: 476 -LNLNGCNSLMKK----------LQHLFAFLAHTQREAYAPRIFFE-ASRPPWFTPRSQQ 523
LN N + K +Q L+ + TQ+ ++ + A P F QQ
Sbjct: 768 LYELNRTNPIGMKGHMAKCYGDLVQELW---SGTQKNVAPLKLRWTIAKYAPRFNGFQQQ 824
Query: 524 DCSEYLRFLLDRLHEEEKILKVQASHKPSEILECSETSLQ-EVASKAAVLTETPRTSDGE 582
D E L FLLD LHE+ + KP L+ S+ EVA++A
Sbjct: 825 DSQELLAFLLDGLHEDLN----RVHEKPYVELKDSDGRPDWEVAAEA-----WDNHLRRN 875
Query: 583 KTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSL 618
++++ +F G+LR+ ++C C S + + F LSL
Sbjct: 876 RSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSL 911
Score = 31.6 bits (70), Expect = 4.1
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 1/69 (1%)
Query: 703 NKDVPQKPGGETTP-SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYL 761
++ V Q + P ++ L F + E L + YYC C + A K + + P L
Sbjct: 1219 HESVEQSRRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHCLATKKLDLWRLPPIL 1278
Query: 762 ILTLLRFSY 770
I+ L RF +
Sbjct: 1279 IIHLKRFQF 1287
>gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [Homo
sapiens]
Length = 2554
Score = 63.9 bits (154), Expect = 7e-10
Identities = 50/191 (26%), Positives = 83/191 (43%), Gaps = 24/191 (12%)
Query: 671 SLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTDLLNYFLAPEI 730
S ++K P+ + C E+ + +N D+ ++ D L ++ ++
Sbjct: 1717 SFADQKICQGCPHRYECEESFTT--------LNVDI------RNHQNLLDSLEQYVKGDL 1762
Query: 731 LTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVL 790
L G N Y+CE C + K + I + P L + L RF YD + K D P L
Sbjct: 1763 LEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPREL 1822
Query: 791 ELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSG 850
++ + + L + D + L ++ + S ++ A TK Y L V+VHSG
Sbjct: 1823 DMEPYTVAGVAKL------EGDNVNPESQLIQQSEQSESETAGSTK---YRLVGVLVHSG 1873
Query: 851 ISSESGHYYSY 861
+S GHYYSY
Sbjct: 1874 QAS-GGHYYSY 1883
Score = 46.6 bits (109), Expect = 1e-04
Identities = 41/151 (27%), Positives = 57/151 (37%), Gaps = 51/151 (33%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCN-------------------- 482
G GL N G TCYMNSVIQ L+M R +L++ G +
Sbjct: 1555 GFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPR 1614
Query: 483 ---------------------------SLMKKLQHLFAFLAHTQREAYAPRIFFEASRPP 515
+++ LQ +F LA ++ + Y PR F++ R
Sbjct: 1615 DDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFR-L 1673
Query: 516 WFTP---RSQQDCSEYLRFLLDRLHEEEKIL 543
W P R Q D E+ L+D L E K L
Sbjct: 1674 WGEPVNLREQHDALEFFNSLVDSLDEALKAL 1704
>gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [Homo
sapiens]
Length = 2570
Score = 63.9 bits (154), Expect = 7e-10
Identities = 50/191 (26%), Positives = 83/191 (43%), Gaps = 24/191 (12%)
Query: 671 SLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTDLLNYFLAPEI 730
S ++K P+ + C E+ + +N D+ ++ D L ++ ++
Sbjct: 1717 SFADQKICQGCPHRYECEESFTT--------LNVDI------RNHQNLLDSLEQYVKGDL 1762
Query: 731 LTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVL 790
L G N Y+CE C + K + I + P L + L RF YD + K D P L
Sbjct: 1763 LEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPREL 1822
Query: 791 ELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSG 850
++ + + L + D + L ++ + S ++ A TK Y L V+VHSG
Sbjct: 1823 DMEPYTVAGVAKL------EGDNVNPESQLIQQSEQSESETAGSTK---YRLVGVLVHSG 1873
Query: 851 ISSESGHYYSY 861
+S GHYYSY
Sbjct: 1874 QAS-GGHYYSY 1883
Score = 46.6 bits (109), Expect = 1e-04
Identities = 41/151 (27%), Positives = 57/151 (37%), Gaps = 51/151 (33%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCN-------------------- 482
G GL N G TCYMNSVIQ L+M R +L++ G +
Sbjct: 1555 GFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPR 1614
Query: 483 ---------------------------SLMKKLQHLFAFLAHTQREAYAPRIFFEASRPP 515
+++ LQ +F LA ++ + Y PR F++ R
Sbjct: 1615 DDVFGYPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFR-L 1673
Query: 516 WFTP---RSQQDCSEYLRFLLDRLHEEEKIL 543
W P R Q D E+ L+D L E K L
Sbjct: 1674 WGEPVNLREQHDALEFFNSLVDSLDEALKAL 1704
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/221 (24%), Positives = 86/221 (38%), Gaps = 31/221 (14%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRR----------------------QVLSLNLNGCNS 483
GL NLGNTC+ N+V+Q L R + L +NL
Sbjct: 196 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 255
Query: 484 LMKKLQHLFAFLAHTQREAYAPRIFFE--ASRPPWFTPRSQQDCSEYLRFLLDRLHEEEK 541
L + + T++ P+ F + F QQD E LR+LLD + EE
Sbjct: 256 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 315
Query: 542 ILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCL 601
IL+ S +++ + + + ++++FGG+L + I C
Sbjct: 316 ------QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCD 369
Query: 602 NCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQD 642
CR+ S E+F DLSL S SV D +++D
Sbjct: 370 QCRTVSLVHESFLDLSLPVLDDQS-GKKSVNDKNLKKTVED 409
Score = 38.5 bits (88), Expect = 0.033
Identities = 66/249 (26%), Positives = 94/249 (37%), Gaps = 76/249 (30%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQ-----------------NAEKTMQITEEPE 759
S+ L F E L N+ CE C Q NA+K M I+ P
Sbjct: 631 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 690
Query: 760 YLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSEN 819
L L L RF Q RK+ ++ P +L+L F +L +N
Sbjct: 691 VLTLHLKRFQ--QAGFNLRKVNKHIKFPEILDL-----APFCTLK------------CKN 731
Query: 820 LAKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSE 879
+A++ V Y L VV HSG + SGHY +YA+ T+ H S
Sbjct: 732 VAEE-----------NTRVLYSLYGVVEHSG-TMRSGHYTAYAKARTANS------HLSN 773
Query: 880 ALALASSQSHLLGRDSPSAVFEQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKD 939
+L D P QD E E +WF +D+ V Q+V T++
Sbjct: 774 L---------VLHGDIP-----QDFE-MESKGQWFHISDTHV-----QAVP--TTKVLNS 811
Query: 940 TAYVLLYKK 948
AY+L Y++
Sbjct: 812 QAYLLFYER 820
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/221 (24%), Positives = 86/221 (38%), Gaps = 31/221 (14%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRR----------------------QVLSLNLNGCNS 483
GL NLGNTC+ N+V+Q L R + L +NL
Sbjct: 197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 256
Query: 484 LMKKLQHLFAFLAHTQREAYAPRIFFE--ASRPPWFTPRSQQDCSEYLRFLLDRLHEEEK 541
L + + T++ P+ F + F QQD E LR+LLD + EE
Sbjct: 257 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 316
Query: 542 ILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCL 601
IL+ S +++ + + + ++++FGG+L + I C
Sbjct: 317 ------QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCD 370
Query: 602 NCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQD 642
CR+ S E+F DLSL S SV D +++D
Sbjct: 371 QCRTVSLVHESFLDLSLPVLDDQS-GKKSVNDKNLKKTVED 410
Score = 38.5 bits (88), Expect = 0.033
Identities = 66/249 (26%), Positives = 94/249 (37%), Gaps = 76/249 (30%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQ-----------------NAEKTMQITEEPE 759
S+ L F E L N+ CE C Q NA+K M I+ P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
Query: 760 YLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSEN 819
L L L RF Q RK+ ++ P +L+L F +L +N
Sbjct: 692 VLTLHLKRFQ--QAGFNLRKVNKHIKFPEILDL-----APFCTLK------------CKN 732
Query: 820 LAKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSE 879
+A++ V Y L VV HSG + SGHY +YA+ T+ H S
Sbjct: 733 VAEE-----------NTRVLYSLYGVVEHSG-TMRSGHYTAYAKARTANS------HLSN 774
Query: 880 ALALASSQSHLLGRDSPSAVFEQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKD 939
+L D P QD E E +WF +D+ V Q+V T++
Sbjct: 775 L---------VLHGDIP-----QDFE-MESKGQWFHISDTHV-----QAVP--TTKVLNS 812
Query: 940 TAYVLLYKK 948
AY+L Y++
Sbjct: 813 QAYLLFYER 821
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/221 (24%), Positives = 86/221 (38%), Gaps = 31/221 (14%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRR----------------------QVLSLNLNGCNS 483
GL NLGNTC+ N+V+Q L R + L +NL
Sbjct: 197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGP 256
Query: 484 LMKKLQHLFAFLAHTQREAYAPRIFFE--ASRPPWFTPRSQQDCSEYLRFLLDRLHEEEK 541
L + + T++ P+ F + F QQD E LR+LLD + EE
Sbjct: 257 LTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQELLRYLLDGMRAEEH 316
Query: 542 ILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRCL 601
IL+ S +++ + + + ++++FGG+L + I C
Sbjct: 317 ------QRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCD 370
Query: 602 NCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQD 642
CR+ S E+F DLSL S SV D +++D
Sbjct: 371 QCRTVSLVHESFLDLSLPVLDDQS-GKKSVNDKNLKKTVED 410
Score = 38.5 bits (88), Expect = 0.033
Identities = 66/249 (26%), Positives = 94/249 (37%), Gaps = 76/249 (30%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQ-----------------NAEKTMQITEEPE 759
S+ L F E L N+ CE C Q NA+K M I+ P
Sbjct: 632 SIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAPP 691
Query: 760 YLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSEN 819
L L L RF Q RK+ ++ P +L+L F +L +N
Sbjct: 692 VLTLHLKRFQ--QAGFNLRKVNKHIKFPEILDL-----APFCTLK------------CKN 732
Query: 820 LAKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSE 879
+A++ V Y L VV HSG + SGHY +YA+ T+ H S
Sbjct: 733 VAEE-----------NTRVLYSLYGVVEHSG-TMRSGHYTAYAKARTANS------HLSN 774
Query: 880 ALALASSQSHLLGRDSPSAVFEQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKD 939
+L D P QD E E +WF +D+ V Q+V T++
Sbjct: 775 L---------VLHGDIP-----QDFE-MESKGQWFHISDTHV-----QAVP--TTKVLNS 812
Query: 940 TAYVLLYKK 948
AY+L Y++
Sbjct: 813 QAYLLFYER 821
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 62.4 bits (150), Expect = 2e-09
Identities = 61/204 (29%), Positives = 89/204 (43%), Gaps = 26/204 (12%)
Query: 430 ASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLS----LNLNGCNSLM 485
+S + R +E G TGL NLGNTC+MNS IQ + + +S LN N +
Sbjct: 517 SSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIG 576
Query: 486 KK----------LQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDR 535
K +Q L++ + R A P F QQD E L FLLD
Sbjct: 577 MKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTI--AKYAPKFDGFQQQDSQELLAFLLDG 634
Query: 536 LHEEEKILKVQASHKPSEILECSETSLQ-EVASKAAVLTETPRTSDGEKTLIEKMFGGKL 594
LHE+ + KP L+ S+ EVA++A +++I +F G+L
Sbjct: 635 LHEDLN----RVHEKPYVELKDSDGRPDWEVAAEA-----WDNHLRRNRSIIVDLFHGQL 685
Query: 595 RTHIRCLNCRSTSQKVEAFTDLSL 618
R+ ++C C S + + F LSL
Sbjct: 686 RSQVKCKTCGHISVRFDPFNFLSL 709
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 1/69 (1%)
Query: 703 NKDVPQKPGGETTP-SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYL 761
++ V Q + P ++ L F + E L YYC C + A K + + P +L
Sbjct: 1017 HESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFL 1076
Query: 762 ILTLLRFSY 770
I+ L RF +
Sbjct: 1077 IIHLKRFQF 1085
>gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]
Length = 485
Score = 62.0 bits (149), Expect = 3e-09
Identities = 41/147 (27%), Positives = 71/147 (48%), Gaps = 35/147 (23%)
Query: 718 VTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVR 777
+TD ++ FL E L GDN+Y+CENC S QNA + +++ P L L L+RF +D++ +
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHK 308
Query: 778 RKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKL 837
+K+ + +L D+ + K G+
Sbjct: 309 KKLNTYIGFSEIL------------------------DMEPYVEHK---GGS-------- 333
Query: 838 VPYLLSSVVVHSGISSESGHYYSYARN 864
Y LS+V++H G+S+ SGHY ++ ++
Sbjct: 334 YVYELSAVLIHRGVSAYSGHYIAHVKD 360
Score = 41.6 bits (96), Expect = 0.004
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 21/110 (19%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCNSLM-----------------KKL 488
GL NLG TCY+N+ +Q F+ + RQ L L + C+ M + L
Sbjct: 90 GLTNLGATCYVNTFLQVWFLNLEL-RQALYLCPSTCSDYMLGDGIQEEKDYEPQTICEHL 148
Query: 489 QHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHE 538
Q+LFA L ++ R P F +A QQD E+ + + L +
Sbjct: 149 QYLFALLQNSNRRYIDPSGFVKAL---GLDTGQQQDAQEFSKLFMSLLED 195
>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
Length = 1035
Score = 62.0 bits (149), Expect = 3e-09
Identities = 41/147 (27%), Positives = 71/147 (48%), Gaps = 35/147 (23%)
Query: 718 VTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVR 777
+TD ++ FL E L GDN+Y+CENC S QNA + +++ P L L L+RF +D++ +
Sbjct: 249 LTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHK 308
Query: 778 RKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKL 837
+K+ + +L D+ + K G+
Sbjct: 309 KKLNTYIGFSEIL------------------------DMEPYVEHK---GGS-------- 333
Query: 838 VPYLLSSVVVHSGISSESGHYYSYARN 864
Y LS+V++H G+S+ SGHY ++ ++
Sbjct: 334 YVYELSAVLIHRGVSAYSGHYIAHVKD 360
Score = 41.6 bits (96), Expect = 0.004
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 21/110 (19%)
Query: 446 GLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNGCNSLM-----------------KKL 488
GL NLG TCY+N+ +Q F+ + RQ L L + C+ M + L
Sbjct: 90 GLTNLGATCYVNTFLQVWFLNLEL-RQALYLCPSTCSDYMLGDGIQEEKDYEPQTICEHL 148
Query: 489 QHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHE 538
Q+LFA L ++ R P F +A QQD E+ + + L +
Sbjct: 149 QYLFALLQNSNRRYIDPSGFVKAL---GLDTGQQQDAQEFSKLFMSLLED 195
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 60.8 bits (146), Expect = 6e-09
Identities = 48/148 (32%), Positives = 65/148 (43%), Gaps = 35/148 (23%)
Query: 717 SVTDLLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHV 776
++ D L F A + L GDN Y CE C L+N K ++ PE L + L RF ++ +
Sbjct: 560 TLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFST 619
Query: 777 RRKILDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTK 836
KI +VS PL + DL LAK S +
Sbjct: 620 --KISTHVSFPL-----------------------EGLDLQPFLAKD---------SPAQ 645
Query: 837 LVPYLLSSVVVHSGISSESGHYYSYARN 864
+V Y L SV+ H G +S SGHY +Y RN
Sbjct: 646 IVTYDLLSVICHHGTAS-SGHYIAYCRN 672
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/136 (33%), Positives = 65/136 (47%), Gaps = 9/136 (6%)
Query: 443 GKTGLINLGNTCYMNSVIQALFMATDFRRQVLS----LNLNGCNSLMKKLQHLFAFLAHT 498
G TGL N+GNTCYMN+ +QAL + L + ++ K L L H
Sbjct: 183 GLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSYLKLMTELWHK 242
Query: 499 QRE-AYAPRIFFEASRP--PWFTPRSQQDCSEYLRFLLDRLHEEEKILKVQASHKPSEIL 555
R + P F+ + P F SQQD E+LR L+D LHEE K ++ P I
Sbjct: 243 SRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQTI- 301
Query: 556 ECSETSLQEVASKAAV 571
+E +++E S++ V
Sbjct: 302 -TTEETMEEDKSQSDV 316
Score = 33.5 bits (75), Expect = 1.1
Identities = 20/71 (28%), Positives = 37/71 (52%), Gaps = 5/71 (7%)
Query: 583 KTLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPS--I 640
+++I +F G + + ++CL C S +E F DLSL P E+++ +S P+ +
Sbjct: 472 RSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSL---PIPGKEDLAKLHSSSHPTSIV 528
Query: 641 QDGGLMQASVP 651
+ G +A P
Sbjct: 529 KAGSCGEAYAP 539
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,615,671
Number of Sequences: 37866
Number of extensions: 1862663
Number of successful extensions: 9433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 102
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 8927
Number of HSP's gapped (non-prelim): 464
length of query: 1042
length of database: 18,247,518
effective HSP length: 112
effective length of query: 930
effective length of database: 14,006,526
effective search space: 13026069180
effective search space used: 13026069180
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.