Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 25952134
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25952134 dispatched A [Homo sapiens]
(1524 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25952134 dispatched A [Homo sapiens] 3168 0.0
gi|25121980 dispatched B [Homo sapiens] 882 0.0
gi|149274653 patched domain containing 2 [Homo sapiens] 86 4e-16
gi|194018513 patched domain containing 3 [Homo sapiens] 62 6e-09
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 57 1e-07
gi|134254450 patched isoform S [Homo sapiens] 50 1e-05
gi|134254435 patched isoform S [Homo sapiens] 50 1e-05
gi|134254468 patched isoform S [Homo sapiens] 50 1e-05
gi|134254452 patched isoform S [Homo sapiens] 50 1e-05
gi|134254432 patched isoform L' [Homo sapiens] 50 1e-05
gi|134254466 patched isoform M [Homo sapiens] 50 1e-05
gi|134254446 patched isoform L [Homo sapiens] 50 1e-05
gi|52145305 patched 2 [Homo sapiens] 46 3e-04
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 41 0.008
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 41 0.008
gi|68448528 mesothelin-like [Homo sapiens] 40 0.013
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 37 0.15
gi|121114306 neurogenic differentiation 1 [Homo sapiens] 36 0.25
gi|37595553 ring finger protein 111 [Homo sapiens] 35 0.55
gi|148271104 patched domain containing 1 [Homo sapiens] 35 0.72
gi|20149633 evolutionarily conserved signaling intermediate in T... 34 0.95
gi|215599065 evolutionarily conserved signaling intermediate in ... 34 0.95
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 33 1.6
gi|20127446 integrin, beta 5 [Homo sapiens] 33 1.6
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 33 1.6
gi|83977459 pleckstrin homology-like domain, family A, member 1 ... 33 1.6
gi|148727298 keratin associated protein 10-6 [Homo sapiens] 33 2.1
gi|47106067 transmembrane emp24 protein transport domain contain... 33 2.1
gi|239048862 checkpoint with forkhead and ring finger domains is... 33 2.8
gi|239752100 PREDICTED: hypothetical protein [Homo sapiens] 33 2.8
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 3168 bits (8214), Expect = 0.0
Identities = 1524/1524 (100%), Positives = 1524/1524 (100%)
Query: 1 MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNG 60
MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNG
Sbjct: 1 MAMSNGNNDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNG 60
Query: 61 TVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPH 120
TVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPH
Sbjct: 61 TVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPH 120
Query: 121 SEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKS 180
SEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKS
Sbjct: 121 SEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKS 180
Query: 181 YAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNM 240
YAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNM
Sbjct: 181 YAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLLGFEPRGTAIGQRLVTWNNM 240
Query: 241 VKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRY 300
VKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRY
Sbjct: 241 VKNTGYKATLANYPFKYADEQAKSHRDDRWSDDHYEREKREVDWNFHKDSFFCDVPSDRY 300
Query: 301 SRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAI 360
SRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAI
Sbjct: 301 SRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHPQFGDLCQRTTAASCCPSWTLGNYIAI 360
Query: 361 LNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTK 420
LNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTK
Sbjct: 361 LNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDMAARRKDQLKCTNVPRKCTK 420
Query: 421 YNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDG 480
YNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDG
Sbjct: 421 YNAVYQILHYLVDKDFMTPKTADYATPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDG 480
Query: 481 VTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLI 540
VTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLI
Sbjct: 481 VTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLI 540
Query: 541 VSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSIT 600
VSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSIT
Sbjct: 541 VSYFLYRVVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSIT 600
Query: 601 LQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHE 660
LQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHE
Sbjct: 601 LQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHE 660
Query: 661 RYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYL 720
RYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYL
Sbjct: 661 RYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHKVLFAISEASRIFFEKVLPCIVIKFRYL 720
Query: 721 WLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHG 780
WLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHG
Sbjct: 721 WLFWFLALTVGGAYIVCINPKMKLPSLELSEFQVFRSSHPFERYDAEYKKLFMFERVHHG 780
Query: 781 EELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFF 840
EELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFF
Sbjct: 781 EELHMPITVIWGVSPEDNGNPLNPKSKGKLTLDSSFNIASPASQAWILHFCQKLRNQTFF 840
Query: 841 YQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERS 900
YQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERS
Sbjct: 841 YQTDEQDFTSCFIETFKQWMENQDCDEPALYPCCSHWSFPYKQEIFELCIKRAIMELERS 900
Query: 901 TGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPE 960
TGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPE
Sbjct: 901 TGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPE 960
Query: 961 GLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTI 1020
GLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTI
Sbjct: 961 GLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTI 1020
Query: 1021 FVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVG 1080
FVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVG
Sbjct: 1021 FVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVG 1080
Query: 1081 SAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTC 1140
SAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTC
Sbjct: 1081 SAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTC 1140
Query: 1141 GQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASH 1200
GQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASH
Sbjct: 1141 GQIPLPKKLQCSAFSHALSTSPSDKGQSKTHTINAYHLDPRGPKSELEHEFYELEPLASH 1200
Query: 1201 SCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHT 1260
SCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHT
Sbjct: 1201 SCTAPEKTTYEETHICSEFFNSQAKNLGMPVHAAYNSELSKSTESDAGSALLQPPLEQHT 1260
Query: 1261 VCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQ 1320
VCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQ
Sbjct: 1261 VCHFFSLNQRCSCPDAYKHLNYGPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLKATHQ 1320
Query: 1321 AVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRS 1380
AVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRS
Sbjct: 1321 AVEGFVHPITHIHHCPCLQGRVKPAGMQNSLPRNFFLHPVQHIQAQEKIGKTNVHSLQRS 1380
Query: 1381 IEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVE 1440
IEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVE
Sbjct: 1381 IEEHLPKMAEPSSFVCRSTGSLLKTCCDPENKQRELCKNRDVSNLESSGGTENKAGGKVE 1440
Query: 1441 LSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPN 1500
LSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPN
Sbjct: 1441 LSLSQTDASVNSEHFNQNEPKVLFNHLMGEAGCRSCPNNSQSCGRIVRVKCNSVDCQMPN 1500
Query: 1501 MEANVPAVLTHSELSGESLLIKTL 1524
MEANVPAVLTHSELSGESLLIKTL
Sbjct: 1501 MEANVPAVLTHSELSGESLLIKTL 1524
>gi|25121980 dispatched B [Homo sapiens]
Length = 1401
Score = 882 bits (2279), Expect = 0.0
Identities = 429/993 (43%), Positives = 631/993 (63%), Gaps = 16/993 (1%)
Query: 162 VQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMCTMFIVVCALVGVLVPELPDFSDPLL 221
VQ H+ ++R R F++PKSY+ LIA+WPV VL +C I +C L G+L LPDFS PLL
Sbjct: 142 VQHHVVSVRQERAFQMPKSYSQLIAEWPVAVLMLCLAVIFLCTLAGLLGARLPDFSKPLL 201
Query: 222 GFEPRGTAIGQRLVTWNNMVKNTGYKATLANYPFKYADEQAKSHRDDR-----WSDDHYE 276
GFEPR T IG +LV W + TG + L P + + SH R + +
Sbjct: 202 GFEPRDTDIGSKLVVWRALQALTGPRKLLFLSPDLELNSSS-SHNTLRPAPRGSAQESAV 260
Query: 277 REKREVD--WNFHKDSFFCDVPSDRYSRVVFTSSGGETLWNLPAIKSMCNVDNSRIRSHP 334
R +R V+ + +++FFC P Y+++VF S+ +LWNL AI SMC ++ +IRSH
Sbjct: 261 RPRRMVEPLEDRRQENFFCGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQIRSHT 320
Query: 335 QFGDLCQRTTAASCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTL 394
FG LCQRT A CCPSW+LGNY+A+L+NRSSC + D + TL LLRTCA +Y +G L
Sbjct: 321 SFGALCQRTAANQCCPSWSLGNYLAVLSNRSSCLDTTQADAARTLALLRTCALYYHSGAL 380
Query: 395 GPDCWDMAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYATPALKYSML 454
P C + + +C VP KC++ +A+YQ+LH+L+D+DF++P+T DY P+LKYS+L
Sbjct: 381 VPSC--LGPGQNKSPRCAQVPTKCSQSSAIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLL 438
Query: 455 FSPTEKGESMMNIYLDNFEN-WNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVI 513
F PT KG S+M+IYLD W +D T++TG++ G+K L + +L+ DTVYP +A+V
Sbjct: 439 FLPTPKGASLMDIYLDRLATPWGLADNYTSVTGMDLGLKQELLRHFLVQDTVYPLLALVA 498
Query: 514 VLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILVGIGADD 573
+ M +Y +S+F+TLM + ++ SL+V++FLY+V F +FPF+NL AL++L + A+
Sbjct: 499 IFFGMALYLRSLFLTLMVLLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSSVCANH 558
Query: 574 AFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCF 633
+ D+W +K P ++ V T+ H + V+ TT+AAFYA+Y+S + A+RC
Sbjct: 559 TLIFFDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVRCL 618
Query: 634 GVYAGTAILVNYVLMVTWLPAVVVLHERYLLNIFTCFKKPQQQIYDNKSCWTVACQKCHK 693
++ GTA+LV+ L + WLPA VLHERYL + + + + ++
Sbjct: 619 ALFMGTAVLVHLALTLVWLPASAVLHERYLARGCARRARGRWEGSAPRRLLLALHRRLRG 678
Query: 694 VLFAISEASRIFFEKVLPCIVIKFRYLWLFWFLALTVGGAYIVCINPKMKLPSLELSEFQ 753
+ A + SR+ F+++LPC VIKFRY+W+ WF AL GGAYI ++P+++LP+L Q
Sbjct: 679 LRRAAAGTSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIAGVSPRLRLPTLPPPGGQ 738
Query: 754 VFRSSHPFERYDAEYKKLFMFERVHHGEELHMPITVIWGVSPEDNGNPLNPKSKGKLTLD 813
VFR SHPFER+DAEY++LF+FE++ GE HMP+ ++WGV P D G+PL+P+S L D
Sbjct: 739 VFRPSHPFERFDAEYRQLFLFEQLPQGEGGHMPVVLVWGVLPVDTGDPLDPRSNSSLVRD 798
Query: 814 SSFNIASPASQAWILHFCQKLRNQTFFYQTDEQDFTSCFIETFKQWMENQDCDEPALYPC 873
+F+ + P +Q W+L C + RNQ+FF E T CF+ET ++WME+ C C
Sbjct: 799 PAFSASGPEAQRWLLALCHRARNQSFFDTLQEGWPTLCFVETLQRWMESPSCARLGPDLC 858
Query: 874 CSHWSFPYKQEIFELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLF 933
C H FP+ + F C+K +M LE+ D G RFD + ++ A+VL+FQ+ +
Sbjct: 859 CGHSDFPWAPQFFLHCLK--MMALEQGPDGTQDL---GLRFDAHGSLAALVLQFQTNFRN 913
Query: 934 TLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVA 993
+ Y + FY EV W+++EL AP GL GWF S LE Y LQ SLS + +GL++A
Sbjct: 914 SPDYNQTQLFYNEVSHWLAAELGMAPPGLRRGWFTSRLELYSLQHSLSTEPAVVLGLALA 973
Query: 994 VAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFA 1053
+AF+ +LL TWN+ +SL+++ ++AGT+ +TVG LVLL W+LN E++ +S +VGLSVDF
Sbjct: 974 LAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSVDFT 1033
Query: 1054 VHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMM 1113
V+Y ++Y L P PDR +V FSL + A A+ A F AG +M+P+TVL Y +LG +M
Sbjct: 1034 VNYCISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLMLPATVLLYRKLGIILM 1093
Query: 1114 LIMCISWAFATFFFQCMCRCLGPQGTCGQIPLP 1146
++ C+S FA+FFFQ +C GP+ CGQI P
Sbjct: 1094 MVKCVSCGFASFFFQSLCCFFGPEKNCGQILWP 1126
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 85.5 bits (210), Expect = 4e-16
Identities = 59/207 (28%), Positives = 96/207 (46%), Gaps = 22/207 (10%)
Query: 488 EFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFITLMTMFAIISSLIVSYFLYR 547
++ ++ + D LL IA ++ +L C S+F++ + +I S +V+ FLY
Sbjct: 452 DYEVRRTFNNDMLLAFISSSCIAALVYILTSC----SVFLSFFGIASIGLSCLVALFLYH 507
Query: 548 VVFHFEFFPFMNLTALIILVGIGADDAFVLCDVWNY-TKFDKPHAETSETVSITLQHAAL 606
VVF ++ +N A ++VGIG DD FV + + T + P TV Q A
Sbjct: 508 VVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTV----QTAGK 563
Query: 607 SMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHERYLLNI 666
+ F TS TTAAA+ AN S I A+ FG++ + ++ ++ +PA + L YL +
Sbjct: 564 ATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPL 623
Query: 667 FTCFKKPQQQIYDNKSCWTVACQKCHK 693
SC T Q C +
Sbjct: 624 -------------ESSCQTSCHQNCSR 637
Score = 69.3 bits (168), Expect = 3e-11
Identities = 50/214 (23%), Positives = 102/214 (47%), Gaps = 24/214 (11%)
Query: 920 IRAVVLEFQSTYLFTLAYEKMHQFYKEVDSWISSELSSAPEG--LSNG------WFVSNL 971
++ + + F+ST + + + Y +S++ +L + PEG L G W +
Sbjct: 1116 VQWISMAFESTTYKGKSSFQTYSDYLRWESFLQQQLQALPEGSVLRRGFQTCEHWKQIFM 1175
Query: 972 EFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLG 1031
E +Q +L + LS+ + + + + T +I++ L ++SI G + + V + G
Sbjct: 1176 EIVGVQSALC-----GLVLSLLICVAAVAVFTTHILLLLPVLLSILGIVCLVVTIMYWSG 1230
Query: 1032 WELNVLESVTISVAVGLSVDFAVHYGVAYRLAPD-----------PDREGKVIFSLSRVG 1080
WE+ +E++++S+ VG SVD+ VH Y LA + R+ + + ++ VG
Sbjct: 1231 WEMGAVEAISLSILVGSSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVG 1290
Query: 1081 SAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMML 1114
A+ +ALTT +A + + + + G + L
Sbjct: 1291 VAIVSSALTTVIATVPLFFCIIAPFAKFGKIVAL 1324
Score = 53.5 bits (127), Expect = 2e-06
Identities = 49/185 (26%), Positives = 87/185 (47%), Gaps = 6/185 (3%)
Query: 939 KMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSV 998
K F + ++ + +S + L G ++L Y+++ + ++ L+A S +A V
Sbjct: 421 KFQSFVVTYVAMLAKQSTSKVQVLYGG---TDLFDYEVRRTFNNDMLLAFISSSCIAALV 477
Query: 999 MLLTTWNIIISLYAIISIAGTIFVTVGSL-VLLGWE-LNVLESVTISVAVGLSVDFAVHY 1056
+LT+ ++ +S + I SI + V + V+ G + L +L V V VG+ VD +
Sbjct: 478 YILTSCSVFLSFFGIASIGLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVF 537
Query: 1057 GVAYRLAPD-PDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLI 1115
YR A D + ++I ++ G A +LTT A A + S + A G FM LI
Sbjct: 538 INTYRQATHLEDPQLRMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLI 597
Query: 1116 MCISW 1120
+ W
Sbjct: 598 VSCCW 602
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 61.6 bits (148), Expect = 6e-09
Identities = 44/198 (22%), Positives = 84/198 (42%), Gaps = 12/198 (6%)
Query: 469 LDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYTKSMFIT 528
LD F N + + I + F + TV P + +L+++ T
Sbjct: 347 LDQFTNIKNILALKKIEVVHFTSLSRQLEFEATSVTVIPVFHLAYILIILFAVTSCFRFD 406
Query: 529 LM------TMFAIISSLIVSYFLYRVVFHFEFFPFMNLTAL--IILVGIGADDAFVLCDV 580
+ F +IS+ + + ++ H PF+ + A +++G+G DD F++
Sbjct: 407 CIRNKMCVAAFGVISAFLAVVSGFGLLLHIGV-PFVIIVANSPFLILGVGVDDMFIMISA 465
Query: 581 WNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTA 640
W+ T + E +S AA+S+ +T+ T A Y +S+ +++CF +Y G
Sbjct: 466 WHKTNLAD---DIRERMSNVYSKAAVSITITTITNILALYTGIMSSFRSVQCFCIYTGMT 522
Query: 641 ILVNYVLMVTWLPAVVVL 658
+L Y +T A + L
Sbjct: 523 LLFCYFYNITCFGAFMAL 540
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 57.4 bits (137), Expect = 1e-07
Identities = 52/232 (22%), Positives = 105/232 (45%), Gaps = 21/232 (9%)
Query: 468 YLDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYT-KSMF 526
++ N++N N + T IE + D + Y + + I L + + + + +
Sbjct: 590 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 649
Query: 527 ITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILV--------GIGADDAFVLC 578
+ I LIV L V F ++ L +I++ +G D+ F+L
Sbjct: 650 VDSKVSLGIAGILIV---LSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFIL- 705
Query: 579 DVWNYTKFDKPHAET-SETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYA 637
V Y + ++ ET + + L A SMF++SF+ AF+ +S + A+ F ++A
Sbjct: 706 -VQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFA 764
Query: 638 GTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKPQQ--QIYDNKSC 683
G A+ ++++L +T +++ L E+ L+IF C + + + ++SC
Sbjct: 765 GLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESC 816
Score = 45.4 bits (106), Expect = 4e-04
Identities = 40/178 (22%), Positives = 76/178 (42%), Gaps = 23/178 (12%)
Query: 973 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTT----WNIIISLYAIISIAGTIFVTVGSLV 1028
FY+ ++ D T+ +G+S+ F V ++ W+ +I I + +F G +
Sbjct: 1087 FYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMF---GVMW 1143
Query: 1029 LLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAAL 1088
L G LN + V + ++ G+SV+F H A+ ++ R + +L+ +GS++
Sbjct: 1144 LWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSG-- 1201
Query: 1089 TTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLP 1146
+ T+ G ++L S F F+F+ + T G I LP
Sbjct: 1202 --------------ITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLP 1245
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 355 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 413
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 414 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 466
Score = 41.2 bits (95), Expect = 0.008
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 836 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 885
Query: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 886 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 940
Query: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 941 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 992
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 355 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 413
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 414 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 466
Score = 41.2 bits (95), Expect = 0.008
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 836 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 885
Query: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 886 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 940
Query: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 941 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 992
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 355 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 413
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 414 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 466
Score = 41.2 bits (95), Expect = 0.008
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 836 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 885
Query: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 886 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 940
Query: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 941 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 992
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 355 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 413
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 414 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 466
Score = 41.2 bits (95), Expect = 0.008
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 836 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 885
Query: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 886 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 940
Query: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 941 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 992
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 505 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 563
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 564 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 616
Score = 41.2 bits (95), Expect = 0.008
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 986 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 1035
Query: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 1036 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 1090
Query: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 1091 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 1142
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 440 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 498
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 499 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 551
Score = 41.2 bits (95), Expect = 0.008
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 921 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 970
Query: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 971 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 1025
Query: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 1026 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 1077
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 50.4 bits (119), Expect = 1e-05
Identities = 29/113 (25%), Positives = 55/113 (48%), Gaps = 5/113 (4%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +G+G DD F+L ++ T +K + L+ S+ +TS + AF+ +
Sbjct: 506 LALGVGVDDVFLLAHAFSETGQNK-RIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL 564
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKP 673
I A+R F + A ++ N+ +++ PA++ + E L+IF CF P
Sbjct: 565 IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSP 617
Score = 41.2 bits (95), Expect = 0.008
Identities = 41/173 (23%), Positives = 79/173 (45%), Gaps = 21/173 (12%)
Query: 933 FTLAYEKMHQFYKEVDSWISSELSSAPEGLSNGWFVSNLEFYDLQDSLSDGTLIAMGLSV 992
F A EK+ ++ S LSS P G F++ L L+ + + +
Sbjct: 987 FVEAIEKVRTI---CSNYTSLGLSSYPNGYP-------FLFWEQYIGLRHWLLLFISVVL 1036
Query: 993 AVAF---SVMLLTTWN--IIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVG 1047
A F +V LL W II+ + A++++ G + L+G +L+ + V + +VG
Sbjct: 1037 ACTFLVCAVFLLNPWTAGIIVMVLALMTVE-----LFGMMGLIGIKLSAVPVVILIASVG 1091
Query: 1048 LSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ V+F VH +A+ L D+ + + +L + + + A++T + M+ S
Sbjct: 1092 IGVEFTVHVALAF-LTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGS 1143
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 45.8 bits (107), Expect = 3e-04
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 7/113 (6%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFYANYV 624
+ +GIG DD F+L + P E + LQ S+ +TS AAF +
Sbjct: 462 LALGIGVDDVFLLAHAFTEAL---PGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAAL 518
Query: 625 SNITAIRCFGVYAGTAILVNYVLMVTWLPAVVVLHER----YLLNIFTCFKKP 673
I A+R F + A + +V ++ PA++ L R L++ CF P
Sbjct: 519 VPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCFSSP 571
Score = 32.3 bits (72), Expect = 3.6
Identities = 22/104 (21%), Positives = 48/104 (46%), Gaps = 4/104 (3%)
Query: 997 SVMLLTTWNIIISLYAIISIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHY 1056
+++LL W + + + + +F +G LG +L+ + V + +VG+ V+F VH
Sbjct: 980 ALLLLNPWTAGLIVLVLAMMTVELFGIMG---FLGIKLSAIPVVILVASVGIGVEFTVHV 1036
Query: 1057 GVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTFVAGAMMMPS 1100
+ + L R + +L + + A++T + M+ S
Sbjct: 1037 ALGF-LTTQGSRNLRAAHALEHTFAPVTDGAISTLLGLLMLAGS 1079
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens]
Length = 1332
Score = 41.2 bits (95), Expect = 0.008
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 3/167 (1%)
Query: 973 FYDLQDSLSDGTLIAMGLSVAVAFSVM-LLTTWNIIISLYAIISIAGTIFVTVGSLVLLG 1031
FY+ ++ L + L + F+V LL ++ L ++SI + TVG + L G
Sbjct: 1101 FYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWG 1160
Query: 1032 WELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTF 1091
N + + + AVG+SV+F H ++ ++ P + + +GSA+ T
Sbjct: 1161 ISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTN 1220
Query: 1092 VAGAMMMPSTVLAYTQLGTFM--MLIMCISWAFATFFFQCMCRCLGP 1136
+ G +++ Q+ F +LI + F + +GP
Sbjct: 1221 LPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1267
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapiens]
Length = 1359
Score = 41.2 bits (95), Expect = 0.008
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 3/167 (1%)
Query: 973 FYDLQDSLSDGTLIAMGLSVAVAFSVM-LLTTWNIIISLYAIISIAGTIFVTVGSLVLLG 1031
FY+ ++ L + L + F+V LL ++ L ++SI + TVG + L G
Sbjct: 1128 FYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWG 1187
Query: 1032 WELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAALTTF 1091
N + + + AVG+SV+F H ++ ++ P + + +GSA+ T
Sbjct: 1188 ISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTN 1247
Query: 1092 VAGAMMMPSTVLAYTQLGTFM--MLIMCISWAFATFFFQCMCRCLGP 1136
+ G +++ Q+ F +LI + F + +GP
Sbjct: 1248 LPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGP 1294
>gi|68448528 mesothelin-like [Homo sapiens]
Length = 1053
Score = 40.4 bits (93), Expect = 0.013
Identities = 47/183 (25%), Positives = 69/183 (37%), Gaps = 37/183 (20%)
Query: 15 NSSIATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPN-----GCLQLNGTVKSSFLPL 69
++S +A PS P D + ++T RT V P C QL+ T LP+
Sbjct: 21 SASPGPTALGPSTFLPWD---VSARMTSARR-RTDVGPRVAFTYPCTQLSPTRAHRHLPV 76
Query: 70 DNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALA--SCCMQPHS-EYSAS 126
+PC P +HS H H P PS SC + H+ Y+ +
Sbjct: 77 HT---------VTYPCTQLSPTRAHSCHLPMHTVTYPCTPSPTRAHSCHLPVHTVTYTCT 127
Query: 127 LCPNHS-------------PVYQTT--CCLQPSPSFC-LHHPWPDHFQHQPVQQHIANIR 170
L P H+ PV+ T C L P+ + C LH H Q ++ +
Sbjct: 128 LSPTHACLHASTVSCLCCIPVHTVTYPCTLSPTCAHCHLHMRARTHPQPHACAVYLCILS 187
Query: 171 PSR 173
P+R
Sbjct: 188 PTR 190
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 37.0 bits (84), Expect = 0.15
Identities = 28/100 (28%), Positives = 48/100 (48%), Gaps = 14/100 (14%)
Query: 889 CIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAV--------VLEFQSTYLFTLAYEKM 940
C + A LE ST + S P P F I+D + A+ V + ++ FT +E +
Sbjct: 1665 CFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSGFTEEFETL 1724
Query: 941 HQFYKE-----VDSWISSELSSAPEGLSNGWFVSNLEFYD 975
+FY+E VD I+++ S+ P+ ++ N+ YD
Sbjct: 1725 KEFYQEVQSCTVDLGITADSSNHPDNKHKNRYI-NIVAYD 1763
>gi|121114306 neurogenic differentiation 1 [Homo sapiens]
Length = 356
Score = 36.2 bits (82), Expect = 0.25
Identities = 40/113 (35%), Positives = 49/113 (43%), Gaps = 14/113 (12%)
Query: 54 GCLQLNGTVKSSFLPLDNQRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALA 113
GCLQLN +FLP NQ MP LP P H S+ S P G S +
Sbjct: 186 GCLQLN---PRTFLPEQNQDMPPHLPTASASFPVHP--YSYQSPGLPSPPYGTMDSSHVF 240
Query: 114 SCCMQPHSEYSASLCP-NHSPVYQTTCCLQPSPSFCLHHPWPDH----FQHQP 161
PH+ YSA+L P SP+ T C PS L P + F+H+P
Sbjct: 241 HVKPPPHA-YSAALEPFFESPL---TDCTSPSFDGPLSPPLSINGNFSFKHEP 289
>gi|37595553 ring finger protein 111 [Homo sapiens]
Length = 986
Score = 35.0 bits (79), Expect = 0.55
Identities = 25/81 (30%), Positives = 31/81 (38%), Gaps = 1/81 (1%)
Query: 103 EAGPAAPSALASCCMQPHSEYSASLCPNHSPVYQTTCCLQPSPSFCLHHPWPDHFQHQPV 162
E GP A L SCC Q HS S +H+ + T C Q HH H H V
Sbjct: 468 ETGPPAMPRLPSCCPQ-HSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAV 526
Query: 163 QQHIANIRPSRPFKLPKSYAA 183
+ P+ P + P A
Sbjct: 527 PVSPSFSDPACPVERPPQVQA 547
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 34.7 bits (78), Expect = 0.72
Identities = 34/129 (26%), Positives = 55/129 (42%), Gaps = 16/129 (12%)
Query: 565 ILVGIGADDAFVLCDVWNYTKFDKPHAETSETVSITLQHAALSMFVTSFTTAAAFY---- 620
+++G G F + W T+ D+ E + V A SM S TTA
Sbjct: 335 VMLGHGLYGTFEMLSSWRKTREDQHVKERTAAVY------ADSMLSFSLTTAMYLVTFGI 388
Query: 621 -ANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVVV----LHERYLLNIFTCFKKPQQ 675
A+ +NI A R F + AI NY+ ++++ + +V + Y +IF C K P+
Sbjct: 389 GASPFTNIEAARIFCCNSCIAIFFNYLYVLSFYGSSLVFTGYIENNYQHSIF-CRKVPKP 447
Query: 676 QIYDNKSCW 684
+ K W
Sbjct: 448 EALQEKPAW 456
>gi|20149633 evolutionarily conserved signaling intermediate in Toll
pathway isoform 1 [Homo sapiens]
Length = 431
Score = 34.3 bits (77), Expect = 0.95
Identities = 25/71 (35%), Positives = 34/71 (47%), Gaps = 17/71 (23%)
Query: 1118 ISWAFATFFFQCMCRCLGPQGTCG---------QIP--LPKKLQCSAFSH----ALSTSP 1162
+SW AT + +CR G GTCG Q+P LP+ L CSA +H +L SP
Sbjct: 1 MSWVQATLLARGLCRAWG--GTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSP 58
Query: 1163 SDKGQSKTHTI 1173
+ Q T +
Sbjct: 59 PEPRQRPTKAL 69
>gi|215599065 evolutionarily conserved signaling intermediate in Toll
pathway isoform 2 [Homo sapiens]
Length = 296
Score = 34.3 bits (77), Expect = 0.95
Identities = 25/71 (35%), Positives = 34/71 (47%), Gaps = 17/71 (23%)
Query: 1118 ISWAFATFFFQCMCRCLGPQGTCG---------QIP--LPKKLQCSAFSH----ALSTSP 1162
+SW AT + +CR G GTCG Q+P LP+ L CSA +H +L SP
Sbjct: 1 MSWVQATLLARGLCRAWG--GTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSP 58
Query: 1163 SDKGQSKTHTI 1173
+ Q T +
Sbjct: 59 PEPRQRPTKAL 69
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 33.5 bits (75), Expect = 1.6
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 2/81 (2%)
Query: 886 FELCIKRAIMELERSTGYHLDSKTPGPRFDINDTIRAVVLEFQSTYLFTLAYEKMHQ-FY 944
F++ RA++ RS Y + G R + + AVV +S YL + + F
Sbjct: 79 FQMVYFRALVNFTRSIEYSPQLEDAGSR-EFREVSEAVVDTLESEYLKIPGDQVVSVVFI 137
Query: 945 KEVDSWISSELSSAPEGLSNG 965
KE+D W+ EL EG ++G
Sbjct: 138 KELDGWVFVELDVGSEGNADG 158
>gi|20127446 integrin, beta 5 [Homo sapiens]
Length = 799
Score = 33.5 bits (75), Expect = 1.6
Identities = 25/88 (28%), Positives = 30/88 (34%), Gaps = 12/88 (13%)
Query: 1267 LNQRCSCPDAYKHLNY--------GPHSCQQMGDCLCHQCSPTTSSFVQIQNGVAPLK-- 1316
L RC C D Y G C GDC C+QCS S F +I
Sbjct: 494 LGTRCECQDGENQSVYQNLCREAEGKPLCSGRGDCSCNQCSCFESEFGKIYGPFCECDNF 553
Query: 1317 --ATHQAVEGFVHPITHIHHCPCLQGRV 1342
A ++ V H H C C G +
Sbjct: 554 SCARNKGVLCSGHGECHCGECKCHAGYI 581
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 33.5 bits (75), Expect = 1.6
Identities = 40/182 (21%), Positives = 61/182 (33%), Gaps = 27/182 (14%)
Query: 19 ATSAANPSPLTPCDGDHAAQQLTPKEATRTKVSPNGCLQLNGTVKSSFLPLDNQRMPQML 78
+T A P+P PC Q P + +VS K + ++ R+P
Sbjct: 3359 STQPAQPAP--PCPPSQLGQPGQPPSSKMPQVSQEA--------KGTQTGVEQPRLPAG- 3407
Query: 79 PQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYS--ASLCPNHSPVYQ 136
P + P H+ Q E GP + + S M+P S P
Sbjct: 3408 -------PANRPPEPHTQVQRAQAETGPTSFPSPVSVSMKPDLPVSLPTQTAPKQPLFVP 3460
Query: 137 TTCCLQPSPSFCLHHPWPDHFQHQPVQQHIANIRPSRPFKLPKSYAALIADWPVVVLGMC 196
TT P L H FQ P Q ++ RP + L+ +P+V G+
Sbjct: 3461 TTSGPSTPPGLVLPH---TEFQPAPKQDSSPHLTSQRPVDM----VQLLKKYPIVWQGLL 3513
Query: 197 TM 198
+
Sbjct: 3514 AL 3515
>gi|83977459 pleckstrin homology-like domain, family A, member 1
[Homo sapiens]
Length = 401
Score = 33.5 bits (75), Expect = 1.6
Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 1/51 (1%)
Query: 72 QRMPQMLPQCCHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSE 122
Q P+ PQ HP P+ HP H HP P P + QPHS+
Sbjct: 338 QPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHP-HPHQIPHPHPQPHSQ 387
>gi|148727298 keratin associated protein 10-6 [Homo sapiens]
Length = 365
Score = 33.1 bits (74), Expect = 2.1
Identities = 24/72 (33%), Positives = 33/72 (45%), Gaps = 11/72 (15%)
Query: 79 PQCCHPCPYHH----PLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSASLCPNHSPV 134
P CC P H P+ S +S C + P+ + C +P S S LC PV
Sbjct: 258 PACCTSSPCQHACCVPVCSGASTSCCQQSS--CQPACCTASCCRPSSSVSL-LC---HPV 311
Query: 135 YQTTCCLQPSPS 146
++TCC+ P PS
Sbjct: 312 CKSTCCV-PVPS 322
>gi|47106067 transmembrane emp24 protein transport domain containing
8 [Homo sapiens]
Length = 325
Score = 33.1 bits (74), Expect = 2.1
Identities = 20/69 (28%), Positives = 32/69 (46%), Gaps = 5/69 (7%)
Query: 8 NDFVVLSNSSIATSAANPSPLTPCDGDHAAQQLTP--KEATRTKVSPNGCLQLNGTVKSS 65
N+ + ++S+ SA +P P C H Q ++P K+AT G L+ VK
Sbjct: 41 NEDLENKDTSLLASATDPEP---CSSPHRPQMVSPVSKDATEDLRKATGPLEAQALVKQD 97
Query: 66 FLPLDNQRM 74
LP D ++
Sbjct: 98 LLPADQAQV 106
>gi|239048862 checkpoint with forkhead and ring finger domains
isoform 2 [Homo sapiens]
Length = 663
Score = 32.7 bits (73), Expect = 2.8
Identities = 21/69 (30%), Positives = 26/69 (37%), Gaps = 9/69 (13%)
Query: 82 CHPCPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSAS-----LCPNHSPVYQ 136
C CP + + H PE P AP AL P + S + +CP
Sbjct: 428 CRQCPEYRRQAAQPPHCPA-PEGEPGAPQALGDA---PSTSVSLTTVQDYVCPLQGSHAL 483
Query: 137 TTCCLQPSP 145
TCC QP P
Sbjct: 484 CTCCFQPMP 492
>gi|239752100 PREDICTED: hypothetical protein [Homo sapiens]
Length = 312
Score = 32.7 bits (73), Expect = 2.8
Identities = 26/72 (36%), Positives = 33/72 (45%), Gaps = 12/72 (16%)
Query: 79 PQCCHP--CPYHHPLTSHSSHQECHPEAGPAAPSALASCCMQPHSEYSASLCPNHSPVYQ 136
P CC P C P+ S +S C + P+ S C +P S S LC PV +
Sbjct: 221 PVCCKPVCCV---PVCSGASSLCCQQSS--CQPACCTSSCCRPSSSVSL-LC---HPVCR 271
Query: 137 TTCCLQPSPSFC 148
TCC+ P PS C
Sbjct: 272 PTCCM-PVPSCC 282
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.134 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,212,240
Number of Sequences: 37866
Number of extensions: 2906964
Number of successful extensions: 7570
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 42
Number of HSP's that attempted gapping in prelim test: 7474
Number of HSP's gapped (non-prelim): 107
length of query: 1524
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1409
effective length of database: 13,892,928
effective search space: 19575135552
effective search space used: 19575135552
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.