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Search of human proteins with 121256621
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
(497 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 991 0.0
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 981 0.0
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 171 2e-42
gi|217330641 IWS1 homolog [Homo sapiens] 99 1e-20
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 98 2e-20
gi|24415404 MDN1, midasin homolog [Homo sapiens] 91 3e-18
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 86 6e-17
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo... 85 1e-16
gi|210032580 SET domain containing 1B [Homo sapiens] 80 3e-15
gi|60097902 filaggrin [Homo sapiens] 79 7e-15
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 79 7e-15
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens] 76 6e-14
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens] 76 6e-14
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 75 1e-13
gi|16445033 ACRC protein [Homo sapiens] 74 2e-13
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 74 2e-13
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 74 3e-13
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 74 4e-13
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 73 7e-13
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 71 2e-12
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 71 2e-12
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 71 2e-12
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 71 3e-12
gi|50962882 G patch domain containing 8 [Homo sapiens] 70 3e-12
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 70 4e-12
gi|4504487 histidine rich calcium binding protein precursor [Hom... 70 6e-12
gi|157738619 smoothelin-like 1 [Homo sapiens] 69 8e-12
gi|55741677 SET domain containing 1A [Homo sapiens] 69 1e-11
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 67 3e-11
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 67 4e-11
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 991 bits (2563), Expect = 0.0
Identities = 497/497 (100%), Positives = 497/497 (100%)
Query: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGL 60
MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGL
Sbjct: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGL 60
Query: 61 GSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGS 120
GSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGS
Sbjct: 61 GSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGS 120
Query: 121 DEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 180
DEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG
Sbjct: 121 DEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 180
Query: 181 GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGG 240
GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGG
Sbjct: 181 GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGG 240
Query: 241 SQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGD 300
SQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGD
Sbjct: 241 SQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGD 300
Query: 301 SQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 360
SQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE
Sbjct: 301 SQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 360
Query: 361 DQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSH 420
DQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSH
Sbjct: 361 DQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSH 420
Query: 421 SSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAY 480
SSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAY
Sbjct: 421 SSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAY 480
Query: 481 HNKPIGDQDDNDCQDGY 497
HNKPIGDQDDNDCQDGY
Sbjct: 481 HNKPIGDQDDNDCQDGY 497
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 981 bits (2536), Expect = 0.0
Identities = 497/513 (96%), Positives = 497/513 (96%), Gaps = 16/513 (3%)
Query: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPL--------------- 45
MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPL
Sbjct: 1 MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE 60
Query: 46 -ANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG 104
ANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG
Sbjct: 61 QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG 120
Query: 105 PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG 164
PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG
Sbjct: 121 PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG 180
Query: 165 GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 224
GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK
Sbjct: 181 GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 240
Query: 225 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 284
ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN
Sbjct: 241 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 300
Query: 285 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 344
SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV
Sbjct: 301 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 360
Query: 345 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 404
SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE
Sbjct: 361 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 420
Query: 405 SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 464
SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ
Sbjct: 421 SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
Query: 465 LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 497
LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY
Sbjct: 481 LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 513
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 171 bits (432), Expect = 2e-42
Identities = 118/471 (25%), Positives = 199/471 (42%), Gaps = 11/471 (2%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
+++S DS + K +++ + ++ SDS+ S SD+ + S
Sbjct: 613 SSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN-------SDSSDSSNSSNS 665
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE-DSDDTIQASEESAPQGQDSA 142
D D D S + D + D + NS SD DS D+ + + S
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725
Query: 143 QDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSD 202
D+++ S D+ + DS + DS+ S+S + S S D S+ D SD
Sbjct: 726 SDSSNSSDSSDSSNSSDSS-DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSD 784
Query: 203 DPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDD 262
+S S + NS+ + +S ++ DS S + S + D
Sbjct: 785 SNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDS 844
Query: 263 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSK--GDSQEDSKENLSQEESQNVDGP 320
D +++ +SDS+ +S+S D+ S DS DS E S + S + S + D
Sbjct: 845 SDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSD 904
Query: 321 SSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSK 380
SS+SS ++ S NSS+S E S ++ D + S S+ DSS++ S
Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964
Query: 381 SESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDS 440
S + S+SS+S N S+ S S ++S S + S SS S S +S + D S+S
Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024
Query: 441 QDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
DSS S + S+S++S SS+ + + + + D+ + D D+
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS 1075
Score = 167 bits (423), Expect = 2e-41
Identities = 117/469 (24%), Positives = 192/469 (40%), Gaps = 3/469 (0%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
N+ S DS+ + + + D SDS+ S + S D + S
Sbjct: 720 NSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDS 779
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
+ D D S D + + + +S SD DS ++ +S S ++
Sbjct: 780 SNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS 839
Query: 144 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 203
D++ S D D S DS+ S+S + S S D +E + SD
Sbjct: 840 DSSDSSDSSDGSDSDSS--NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDS 897
Query: 204 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 263
S S+ +S +S S S ++SE +N+ D+ S + S + D
Sbjct: 898 SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSS 957
Query: 264 SELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSE 323
+ D +N+ + S+S+++S+S ++ S DS S N S + SS
Sbjct: 958 NSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSN 1017
Query: 324 SSQEANLSSQENSSESQEEVVSESRGDNPDPT-TSYVEDQEDSDSSEEDSSHTLSHSKSE 382
SS +N S NSS+S + S D+ D + +S + DS S + S + S S+
Sbjct: 1018 SSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1077
Query: 383 SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQD 442
S + S+SS+S N S+ S S ++S S + S SS S S +S D SDS D
Sbjct: 1078 SSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1137
Query: 443 SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
SS S + S+S+ES SS+ + + + D+ + D D+
Sbjct: 1138 SSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1186
Score = 165 bits (418), Expect = 8e-41
Identities = 132/485 (27%), Positives = 212/485 (43%), Gaps = 35/485 (7%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
N++++ S+ KG + + + + SDS+ S + SD + S S
Sbjct: 534 NDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSS--------SDSDSSDS 585
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
D D + DS D + D S D + +S SD SD + S+ S + +
Sbjct: 586 DSSDSSDSDSSDSSNSSDSSDSS--DSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSS 643
Query: 144 DTTSESRELDNEDRVDSK--------PEGGDSTQESESEEHWVGGGSDGESSHGDGSELD 195
D+ S S DN D DS + DS+ S S + S S + SE
Sbjct: 644 DSNS-SDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESS 702
Query: 196 DEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKS 255
D SD S S+ NS NS+ S S ++S+ +N+ DS S + S
Sbjct: 703 DSSDSSDSDSSDSSDSSNS--NSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDS----- 755
Query: 256 RISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQ 315
S+ D S D++ + SDS+++SNS D+ S DS DS S + S + S
Sbjct: 756 --SDSSDSSNSSDSSDSSD-SSDSSDSSNSSDSNDSSNSSDSS-DSSNSSDSSNSSDSSD 811
Query: 316 NVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHT 375
+ D S+SS ++ S+ +SS+S S D+ D + S ++ DS +S + S +
Sbjct: 812 SSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS 871
Query: 376 LSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 435
S + S+S + +ESS S + S+ S S D + SS S SS++ SE S+S +
Sbjct: 872 DSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSD 931
Query: 436 -----DDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDD 490
D S+S DSS S + SNS++S +SS+ + + S + + + D
Sbjct: 932 NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991
Query: 491 NDCQD 495
+D D
Sbjct: 992 SDSSD 996
Score = 165 bits (417), Expect = 1e-40
Identities = 126/468 (26%), Positives = 206/468 (44%), Gaps = 22/468 (4%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
+++S DS + + + + D SDS+ S S D + S
Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNS 900
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
D D + + D+ +S + NS +S D+ +S+ S ++
Sbjct: 901 SDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS 960
Query: 144 DTT--SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQS 201
D++ S+S + ++ D DS DS+ S+S + S S D S+ D S
Sbjct: 961 DSSNSSDSSDSNSSDSSDSS-NSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSS 1019
Query: 202 DDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED 261
D S S+ NS +S S +S ++S+ +++ DS S S S+
Sbjct: 1020 DSSNS--SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS-------SDSS 1070
Query: 262 DRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPS 321
D S+ D++ E SDS+++SNS D+ S DS DS + S + S + S + D S
Sbjct: 1071 DSSDSSDSSDSSE-SSDSSDSSNSSDSSDSSDSSDSS-DSSDSSDSSDSSDSSNSSD--S 1126
Query: 322 SESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKS 381
S+SS ++ S NSS+S + S D+ D + S D DS S + S + S S
Sbjct: 1127 SDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDS--SDSSDSSDSSDSSDSSNSSDSS 1184
Query: 382 ESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQ 441
+S + S+SS+S + S+ S S ++S S + S SS S S ES D SDS
Sbjct: 1185 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSS 1244
Query: 442 DSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQD 489
DSS S + S+S++S S+ + N E +S+ + + +N D D
Sbjct: 1245 DSSNSSDSSDSSDSSDSTSD----SNDESDSQSKSGNGNNNGSDSDSD 1288
Score = 163 bits (413), Expect = 3e-40
Identities = 125/486 (25%), Positives = 217/486 (44%), Gaps = 38/486 (7%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
N++ DS ++ Q P ++E + + E + + S+ G G
Sbjct: 446 NSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGS 505
Query: 84 DDK--DDDEDDSGDDTFGDDDSGPG-----PKDRQEGGNSRL-GSDEDSDDTIQASEESA 135
D K +DD+ DS DT D +G G D+ + G + SD DS D+ +S+ S
Sbjct: 506 DSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSD 565
Query: 136 PQGQDSAQDTTSESRELDNEDRVDSK-PEGGDSTQESESEEHWVGGGSDGESSHGDGSEL 194
DS+ +S + + D DS + DS+ S+S + S S D S+
Sbjct: 566 SSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD------SSDSSDSSDSSDS 619
Query: 195 DDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRK 254
D S ES S+ +S+ +S+ S +S +NS+ +++ +S S
Sbjct: 620 SDSKSDSSKSESDSSD-SDSKSDSSDSNSSDSSDNSDSSDSSNSSNS------------- 665
Query: 255 SRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEES 314
S+ D S+ D+++ + S+S+++S+S D+ S DS S DS ++ S
Sbjct: 666 ---SDSSDSSDSSDSSSSSD-SSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNS 721
Query: 315 QNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPT-TSYVEDQEDSDSSEEDSS 373
+ D SS SS ++ S+ +SS+S + S D+ D + +S D DS S + S+
Sbjct: 722 NSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 781
Query: 374 HTLSHSKSESREEQADSESSESLNFSE--ESPESPEDENSSSQEGLQSHSSSAESQSEES 431
+ S+ S S + S SS+S N S+ +S +S + ++S+S + S SS S S +S
Sbjct: 782 SSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDS 841
Query: 432 HSEEDDSD--SQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQD 489
D SD DSS + SNS++S SS+ + + + ++ + +
Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSS 901
Query: 490 DNDCQD 495
D+D D
Sbjct: 902 DSDSSD 907
Score = 163 bits (413), Expect = 3e-40
Identities = 124/480 (25%), Positives = 201/480 (41%), Gaps = 16/480 (3%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
N+ES+++ +G + N + SDS +E+ DD S G G
Sbjct: 478 NSESDNNSSSRGDASYNSDESKDNGNGSDSKGAED----DDSDSTSDTNNSDSNGNGNNG 533
Query: 84 DDKDDDED------DSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQ 137
+D +D D DS D D + D + +S S DSD + S +S+
Sbjct: 534 NDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDS 593
Query: 138 GQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDE 197
+ +++ S D+ D DS + S+SE S +SS + S+ D
Sbjct: 594 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN 653
Query: 198 GMQSDDPESIRS-ERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSR 256
SD S S + +S +S S +S +S+ +++ DS S E S
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSS--ESSDSSDSSDSD 711
Query: 257 ISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN 316
S+ D S + +++ SDS+++SNS D+ S +S S N S +
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 771
Query: 317 VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE-DSSHT 375
SS+SS ++ + NSS+S + S ++ D + S D DSDSS DSS++
Sbjct: 772 DSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS--SDSSDSDSSNSSDSSNS 829
Query: 376 LSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 435
S S + + +DS S + S+ S S +S S + S +SS S S +S+
Sbjct: 830 SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS 889
Query: 436 DDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 495
+ SDS DSS S + +S S SS D + ES + ++ + D +D D
Sbjct: 890 NSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSD 949
Score = 163 bits (413), Expect = 3e-40
Identities = 123/479 (25%), Positives = 201/479 (41%), Gaps = 25/479 (5%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
+++S DS + + + ++ D SDS+ S SD S S+
Sbjct: 686 SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS---------SNSSDSSD 736
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE-DSDDTIQASEESAPQGQDSA 142
D DS D + D S D + NS SD DS D+ +S S ++
Sbjct: 737 SSNSSDSSDSSDSSNSSDSS-----DSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS 791
Query: 143 QDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHG-DGSELDDEGMQS 201
D++ S D+ + DS S +S + +SS+ D S+ D S
Sbjct: 792 SDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS 851
Query: 202 DDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED 261
D S RS+ NS +S S S ++S+ +++ +S S S S S
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS 911
Query: 262 DRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSK-----GDSQEDSKENLSQEESQN 316
S N++ S+S++NSNS D+ S DS DS S + S + S +
Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 971
Query: 317 VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTL 376
SS+SS ++ S +SS+S + S + D+ D + S S+ DSS++
Sbjct: 972 NSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSS 1031
Query: 377 SHSKSESREEQADS----ESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH 432
S S + +DS +SS+S N S+ S S ++S S + S SS S S +S
Sbjct: 1032 DSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSS 1091
Query: 433 SEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
+ D SDS DSS S + S+S++S SS+ + + + D+ ++ D ++
Sbjct: 1092 NSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES 1150
Score = 161 bits (408), Expect = 1e-39
Identities = 121/445 (27%), Positives = 197/445 (44%), Gaps = 24/445 (5%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPG 106
+ D SDS+ S +G SD +RS D D D S D
Sbjct: 838 SSDSSDSSDSSDGSDSDSS----------NRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE 887
Query: 107 PKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGD 166
+ + +S SD DS D+ +S+ S ++ D++ S DN + DS D
Sbjct: 888 SSNSSDSSDSSNSSDSDSSDSSNSSDSS---DSSNSSDSSESSNSSDNSNSSDSS-NSSD 943
Query: 167 STQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKES 226
S+ S+S S S+ D S+ + S S+ +S +S S S
Sbjct: 944 SSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNS 1003
Query: 227 GENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR 286
++S+ +++ DS S + S S S+ D S+ D++ + SDS+++SNS
Sbjct: 1004 SDSSDSSDSSDSSNSSDSSNSSDS----SNSSDSSDSSDSSDSSDSSD-SSDSSDSSNSS 1058
Query: 287 DTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE 346
D+ S DS DS + S + S E S + D SS SS ++ S +SS+S + S
Sbjct: 1059 DSSDSSDSSDSS-DSSDSSDSSDSSESSDSSD--SSNSSDSSDSSDSSDSSDSSDSSDSS 1115
Query: 347 SRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESP 406
D+ + + S D DS S + S+ + S SES + S+SS+S + S+ S S
Sbjct: 1116 DSSDSSNSSDS--SDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSD 1173
Query: 407 EDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLK 466
++S+S + S SS S S +S D SDS DSS S + S+S++S SS+ +
Sbjct: 1174 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNE 1233
Query: 467 NIEIESRKLTVDAYHNKPIGDQDDN 491
+ + + D+ ++ D D+
Sbjct: 1234 SSDSSDSSDSSDSSNSSDSSDSSDS 1258
Score = 160 bits (406), Expect = 2e-39
Identities = 125/456 (27%), Positives = 198/456 (43%), Gaps = 28/456 (6%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPG 106
+ D SDS+ S + S D + S S D K D D + D+ + DS
Sbjct: 604 SSDSSDSSDSSDSSDSSDS----KSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSS-- 657
Query: 107 PKDRQEGGNSRLGSDE-DSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGG 165
D NS SD DS D+ +S+ S + D+++ S D+ D DS
Sbjct: 658 --DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS 715
Query: 166 DSTQESESEEHWVGGGSDGE--SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKS 223
+ S S + SD S+ D S+ D SD +S S+ NS +S S
Sbjct: 716 SDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS--SDSSNSSDSSDSSDS 773
Query: 224 KESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENS 283
+S ++S +++ DS S S S S+ D S+ D+++ SDS+ +S
Sbjct: 774 SDSSDSSNSSDSNDSSNSSDSSDSSNSS-DSSNSSDSSDSSDSSDSDSSNS--SDSSNSS 830
Query: 284 NSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEV 343
+S D+ S DS S ++ ++ +S N SS+SS ++ S+ +SS+S +
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSN----SSDSSDSSDSSNSSDSSDSSDSN 886
Query: 344 VSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESP 403
S + D+ D + S D DS +S + S + S SES +S SS+S N S+ S
Sbjct: 887 ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946
Query: 404 ESPEDENSSSQEGLQSHSSSAESQSEESHSEE--------DDSDSQDSSRSKEDSNSTES 455
S +S S S +SS S S S S + D SDS DSS S + SNS++S
Sbjct: 947 SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDS 1006
Query: 456 KSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
SS+ + + + + ++ + D D+
Sbjct: 1007 SDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDS 1042
Score = 160 bits (405), Expect = 2e-39
Identities = 123/483 (25%), Positives = 195/483 (40%), Gaps = 28/483 (5%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
N+ S S+ + + + D SDS+ S+ SD S S+
Sbjct: 786 NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDS-----------SNSSDSSD 834
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE----DSDDTIQASEES-APQG 138
D DS D + G D D +S SD DS D+ ++E S +
Sbjct: 835 SSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS 894
Query: 139 QDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELD--- 195
DS+ + S+S + N DS++ S S ++ S S D S+
Sbjct: 895 SDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSS 954
Query: 196 DEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKS 255
D SD S S NS +S S +S ++S+ +++ DS S S
Sbjct: 955 DSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1014
Query: 256 RISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQ 315
+ D + D +N+ + SDS+++S+S D+ S DS S + S
Sbjct: 1015 SSNSSDSSNSSDSSNSSDS--SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDS 1072
Query: 316 NVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPT-------TSYVEDQEDSDSS 368
+ SS+SS+ ++ S NSS+S + S D+ D + +S D DS S
Sbjct: 1073 SDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1132
Query: 369 EEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQS 428
+ S + S S+S E S+SS+S + S+ S S ++S S S SS S S
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1192
Query: 429 EESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQ 488
+S D SDS DSS S + S+S++S SS+ + E + D+ + D
Sbjct: 1193 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDS 1252
Query: 489 DDN 491
D+
Sbjct: 1253 SDS 1255
Score = 159 bits (402), Expect = 6e-39
Identities = 116/446 (26%), Positives = 189/446 (42%), Gaps = 9/446 (2%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPG 106
+ D SDS+ S S+D + + S D D D S D+ DS
Sbjct: 770 SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSS-N 828
Query: 107 PKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGD 166
D + NS SD SD + + +S+ + S +S+S + N + +
Sbjct: 829 SSDSSDSSNSSDSSD-SSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNE 887
Query: 167 STQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSA-GMKSKE 225
S+ S+S + SD +SS D S D S+ +S S + NS+ S +
Sbjct: 888 SSNSSDSSDS--SNSSDSDSS--DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSD 943
Query: 226 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNS 285
S ++S+ +N+ DS S + S S S + S +++ SDS+++SNS
Sbjct: 944 SSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNS 1003
Query: 286 RDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS 345
D+ S DS S + + S + SS+SS ++ S +SS S + S
Sbjct: 1004 SDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1063
Query: 346 ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPES 405
D+ D + S D DS S + S + S S+S + S+SS+S + S+ S S
Sbjct: 1064 SDSSDSSDSSDS--SDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1121
Query: 406 PEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQL 465
++S S + S SS S S +S D SDS DSS S + S+S++S SS+
Sbjct: 1122 NSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSS 1181
Query: 466 KNIEIESRKLTVDAYHNKPIGDQDDN 491
+ + + D+ + D D+
Sbjct: 1182 DSSDSSDSSDSSDSSDSSDSSDSSDS 1207
Score = 159 bits (401), Expect = 7e-39
Identities = 123/459 (26%), Positives = 198/459 (43%), Gaps = 21/459 (4%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPG 106
N D+ +S+ G G D + S D D D D+ DS
Sbjct: 531 NNGNDDNDKSDSGKGKSD-------SSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSS 583
Query: 107 PKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESR--ELDNEDRVDSKPEG 164
D + +S +S D+ +S+ S + D+ S+S E D+ D DSK +
Sbjct: 584 DSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS-DSKSDS 642
Query: 165 GDS--TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 222
DS + S++ + S S D S+ D SD S S + NS+
Sbjct: 643 SDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESS 702
Query: 223 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 282
+S+ +++ DS S + S S S D S+ D++ + SDS+++
Sbjct: 703 DSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD-SSDSSDS 761
Query: 283 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGP-SSESSQEANLSSQENSSESQE 341
SNS D+ S DS DS S N S S + D SS+SS ++ S +SS+S
Sbjct: 762 SNSSDSSDSSDSSDSS-DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDS 820
Query: 342 EVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEE 401
S+S + +S D DS S D S + S ++S+S S+SS+S N S+
Sbjct: 821 SNSSDSSNSSDSSDSSNSSDSSDSSDSS-DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879
Query: 402 SPESPEDENSSSQEGLQSHSSSAESQSEESHSEE--DDSDSQD---SSRSKEDSNSTESK 456
S S +E+S+S + S +SS S+ S+S + D S+S D SS S ++SNS++S
Sbjct: 880 SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSS 939
Query: 457 SSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 495
+SS+ + + D+ ++ D + +D D
Sbjct: 940 NSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978
Score = 156 bits (394), Expect = 5e-38
Identities = 125/485 (25%), Positives = 203/485 (41%), Gaps = 36/485 (7%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
+N S DS+ + + + ++ D SDS+ S + S D S +
Sbjct: 574 SNSSSDSDS-----SDSDSSDSSDSDSSDSSNSSDSSDSSDSS-----DSSDSSDSSDSK 623
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSD----------EDSDDTIQASEE 133
D E DS D D S D + +S S+ DS D+ +S+
Sbjct: 624 SDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDS 683
Query: 134 SAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDG--ESSHGDG 191
S + D+++ S D+ D DS + S S + SD S+ D
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743
Query: 192 SELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKI 251
S+ D SD +S S+ NS +S S +S ++S +++ DS S S
Sbjct: 744 SDSSDSSNSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS- 800
Query: 252 FRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQ 311
S S+ D S+ D+++ SDS+ +S+S D+ S DS S ++ ++
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSN--SSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNR 858
Query: 312 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 371
+S N SS+SS ++ S+ +SS+S + S + D+ D + S D DS +S +
Sbjct: 859 SDSSN----SSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS 914
Query: 372 SSHTLSHSKSESREEQADSESSESLNFSE-----ESPESPEDENSSSQEGLQSHSSSAES 426
S + S SES +S SS+S N S+ +S S + NSS S S S
Sbjct: 915 SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSS 974
Query: 427 QSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIG 486
S +S + D SDS DSS S + S+S+ S SS+ + + D+ ++
Sbjct: 975 DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034
Query: 487 DQDDN 491
D D+
Sbjct: 1035 DSSDS 1039
Score = 155 bits (392), Expect = 8e-38
Identities = 122/425 (28%), Positives = 193/425 (45%), Gaps = 45/425 (10%)
Query: 76 SRSTGKGGDDKDDDEDDS----GDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQAS 131
S G DD + + D++ GD ++ D+S KD G +S+ D+DSD T
Sbjct: 467 SSDESNGNDDANSESDNNSSSRGDASYNSDES----KDNGNGSDSKGAEDDDSDST---- 518
Query: 132 EESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDG 191
S DS + + + + D D K + DS S SD +SS +
Sbjct: 519 --SDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNS 576
Query: 192 SELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKI 251
S D + SD +S S+ +S +S S +S ++S+ +++ DS S
Sbjct: 577 SS-DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS--------KSDSS 627
Query: 252 FRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQ 311
+S S+ D +S+ D+N+ SDS++NS+S D+ S DS S DS ++ S
Sbjct: 628 KSESDSSDSDSKSDSSDSNS-----SDSSDNSDSSDSSNSSNSSDSSDSS--DSSDSSSS 680
Query: 312 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 371
+S N SS+SS +N S +SS+S + S+S D +S+SS+ D
Sbjct: 681 SDSSN-SSDSSDSSDSSNSSESSDSSDSSDSDSSDS------------SDSSNSNSSDSD 727
Query: 372 SSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEES 431
SS+ S S+S S+SS+S N S+ S S +S S + S SS S S +S
Sbjct: 728 SSN--SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785
Query: 432 HSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
+ + SDS DSS S + SNS++S SS+ + +S + + + D +
Sbjct: 786 NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSS 845
Query: 492 DCQDG 496
D DG
Sbjct: 846 DSSDG 850
Score = 149 bits (376), Expect = 6e-36
Identities = 120/445 (26%), Positives = 194/445 (43%), Gaps = 29/445 (6%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
+++S DS E + + ++ D SDS+ S + S + + S S+
Sbjct: 879 SSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN-------SSDSSESSNSSD 931
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQ-EGGNSRLGSDEDSDDTIQASEESAPQGQDSA 142
+ D +S D + D S + NS SD +S D+ +S S +
Sbjct: 932 NSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDS 991
Query: 143 QDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSD 202
D++ S ++ D DS DS+ S S + S S D S+ D SD
Sbjct: 992 SDSSDSSDSSNSSDSSDSS----DSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSD 1047
Query: 203 DPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDD 262
+S S+ NS +S S +S ++S+ +++ DS S S S S+ D
Sbjct: 1048 SSDS--SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESS----DSSDSSNSSDSSDSSD 1101
Query: 263 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 322
S+ D++ + SDS+++SNS D+ S DS DS S + S E S + D SS
Sbjct: 1102 SSDSSDSSDSSD-SSDSSDSSNSSDSSDSSDSSDS-SDSSNSSDSSDSSESSDSSD--SS 1157
Query: 323 ESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE 382
+SS ++ S +SS+S + S D+ D + S D DS S + S + S S+
Sbjct: 1158 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS--SDSSDSSDSSDSSDSSDSSDSSD 1215
Query: 383 SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQD 442
S + S+SS+S + +E S S ++S S S+SS + S+ S S D +D D
Sbjct: 1216 SSDSSDSSDSSDSSDSNESSDSSDSSDSSDS-----SNSSDSSDSSDSSDSTSDSNDESD 1270
Query: 443 SSRSKEDSNSTESKSSSEEDGQLKN 467
S + N+ S S S+ +G N
Sbjct: 1271 SQSKSGNGNNNGSDSDSDSEGSDSN 1295
Score = 134 bits (337), Expect = 2e-31
Identities = 108/425 (25%), Positives = 182/425 (42%), Gaps = 27/425 (6%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
++ S DS+ + + + D S+S+ S + S D + S S+
Sbjct: 897 SSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSD-------SSNSSDSSDSSD 949
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDE-DSDDTIQASEESAPQGQDSA 142
D +S D + D S D + NS SD DS D+ +S+ S +
Sbjct: 950 SSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1009
Query: 143 QDTTSESRELDNEDRVDSK--PEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQ 200
D++ S D+ + DS + DS+ S+S + S S+ D S+ D
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1069
Query: 201 SDDPESI-RSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISE 259
SD +S S+ S +S S +S ++S+ +++ DS S S S S+
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSS----DSSDSSDSSNSSD 1125
Query: 260 EDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDG 319
D S+ D++ SDS+++S S D+ S DS S DS ++ +S N
Sbjct: 1126 SSDSSDSSDSSDSSN-SSDSSDSSESSDSSDSSDSSDSSDSS--DSSDSSDSSDSSN--- 1179
Query: 320 PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS 379
SS+SS ++ S +SS+S + S D+ D + D DS S + S + S+
Sbjct: 1180 -SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS-----DSSDSSDSSDSSDSSDSNE 1233
Query: 380 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD 439
S+S + S+SS S + S+ S S +S+ + QS S + + +S S+ + SD
Sbjct: 1234 SSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSD 1293
Query: 440 SQDSS 444
S S+
Sbjct: 1294 SNHST 1298
Score = 134 bits (336), Expect = 2e-31
Identities = 104/415 (25%), Positives = 170/415 (40%), Gaps = 23/415 (5%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
+N S+ S+ + + N + SDS+ S + S D + + S
Sbjct: 909 SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSS---NSSDSSNSSDSSNS 965
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
D D D+ DS +S + DS D+ +S+ S ++
Sbjct: 966 SDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSS 1025
Query: 144 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 203
D+++ S D+ D DS DS+ S+S + S S D S+ D SD
Sbjct: 1026 DSSNSSDSSDSSDSSDSS----DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS 1081
Query: 204 PESI-RSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDD 262
ES S+ NS +S S +S ++S+ +++ DS S S S+ D
Sbjct: 1082 SESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS----------NSSDSSDSSD 1131
Query: 263 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 322
S+ D++ + SDS+E+S+S D+ S DS S + S + SS
Sbjct: 1132 SSDSSDSSNSSD-SSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1190
Query: 323 ESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE 382
+SS ++ S +SS+S + S D+ D + S D DS+ S + S + S S
Sbjct: 1191 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS--SDSSDSNESSDSSDSSDSSDSSN 1248
Query: 383 SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDD 437
S + S+SS+S + S + +S + + G S S S S S +HS DD
Sbjct: 1249 SSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDS--NHSTSDD 1301
Score = 109 bits (272), Expect = 7e-24
Identities = 128/518 (24%), Positives = 209/518 (40%), Gaps = 59/518 (11%)
Query: 25 NESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGD 84
NE + E W G +A T ++ ++ G I AG +RS G
Sbjct: 101 NEEGNIEGWNGDTGKAET--YGHDGIHGKEENITANGIQGQVSIIDNAGATNRSNTNGNT 158
Query: 85 DKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQAS-------EESAPQ 137
DK+ D GD +D + Q G++ S ++ D+ I+ S E PQ
Sbjct: 159 DKNTQNGDVGDAGHNEDVAVVQEDGPQVAGSNN--STDNEDEIIENSCRNEGNTSEITPQ 216
Query: 138 ------GQDSAQDT--TSESRELDNEDRVDSKPEGGDSTQESES---EEHWVGGGSDGES 186
G A+ T T E LDN D S G D ++ S E+ G G D S
Sbjct: 217 INSKRNGTKEAEVTPGTGEDAGLDNSDGSPSG-NGADEDEDEGSGDDEDEEAGNGKDS-S 274
Query: 187 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSA-----------GMKSKESGENSEQANT 235
++ G E D G + D SI + G K+ +S ENS A
Sbjct: 275 NNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENS--AGI 332
Query: 236 QDSGGSQLLEHPSRKIFRKS-----RISEEDDRSELDDNNTME-EVKSDSTENSN-SRDT 288
+ GSQ +E + R+S RI++E + + + E+K S+ N N +++
Sbjct: 333 PEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEV 392
Query: 289 GLSQPRRDSKGD-SQEDSKENL-SQEESQNVDGPSSESSQ-----EANLSSQENSSESQE 341
G ++ KG K N+ +Q E N++GP +S +N S NS
Sbjct: 393 GKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDS 452
Query: 342 EVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHT----LSHSKSESREEQ--ADSESSES 395
+ DP +S + D +SE D++ + S++ ES++ +DS+ +E
Sbjct: 453 YDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAED 512
Query: 396 LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKE--DSNST 453
+ S + D N + G + S + + S+ D SDS +SS S + DS+S+
Sbjct: 513 DDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572
Query: 454 ESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
+S SSS+ D + S + D+ ++ D D+
Sbjct: 573 DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDS 610
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 98.6 bits (244), Expect = 1e-20
Identities = 106/433 (24%), Positives = 171/433 (39%), Gaps = 42/433 (9%)
Query: 83 GDDKDD-------DEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESA 135
GD DD DE DSG D G+DD G R +E SD E+
Sbjct: 8 GDQSDDGGATPVQDERDSGSD--GEDDVNEQHSGSDTGSVERHSENETSD-----REDGL 60
Query: 136 PQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS----HGDG 191
P+G E L+ D +S+ +SESEE SD E+ HG
Sbjct: 61 PKGHHVTDSENDEPLNLNASDS-ESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSD 119
Query: 192 SELDDE----GMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 247
SE ++ G S++ E + +S G K +SE Q S S
Sbjct: 120 SESEETRKLPGSDSENEELLNGHASDSENEDVG---KHPASDSEIEELQKSPASDSETED 176
Query: 248 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 307
+ K SEE R + D+ E K S+S L +P+ S +S+E +
Sbjct: 177 ALKPQISDSESEEPPRHQASDSENEEPPKP---RMSDSESEELPKPQV-SDSESEEPPRH 232
Query: 308 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE--SRGDNPDPTTSYVEDQEDS 365
S E++ + P S+ + + S EE+ S ++ DP + D E
Sbjct: 233 QASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSE-- 290
Query: 366 DSSEEDSSHTLSHSKSESREEQADSES-SESLNFSEESPESPED---ENSSSQEGLQSHS 421
+EE +S S+SE ++ S+S +E + ++ PES +D EN +Q+ S
Sbjct: 291 --NEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDS 348
Query: 422 SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR--KLTVDA 479
++S + DS+ ++ + K DS+ E + E+ + K + + A
Sbjct: 349 FHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASA 408
Query: 480 YHNKPIGDQDDND 492
++ + D DD+D
Sbjct: 409 KKSRVVSDADDSD 421
Score = 80.1 bits (196), Expect = 4e-15
Identities = 111/490 (22%), Positives = 186/490 (37%), Gaps = 68/490 (13%)
Query: 19 VTRYQNNESEDSEEW--KGH-LAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGF 75
V R+ NE+ D E+ KGH + + N + SDS +SEE ++R
Sbjct: 45 VERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDS-ESEE---------LHRQKDSD 94
Query: 76 SRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ---ASE 132
S S + D E++ + D +S E GSD ++++ + +
Sbjct: 95 SESEERAEPPASDSENEDVNQHGSDSES--------EETRKLPGSDSENEELLNGHASDS 146
Query: 133 ESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQ--ESESEEHWVGGGSDGES---- 186
E+ G+ A D SE EL DS+ E Q +SESEE SD E+
Sbjct: 147 ENEDVGKHPASD--SEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPP 204
Query: 187 ----SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 242
S + EL + + E + + N K + S SE + S+
Sbjct: 205 KPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSE 264
Query: 243 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVK---SDS---------TENSNSRDTGL 290
E P +I SE+ R++ D+ E K SDS +S + D
Sbjct: 265 NEELPKPRISDSE--SEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASR 322
Query: 291 SQPRRDSKGDSQEDSK------ENLSQEESQNVDGP---SSESSQEANLSSQENSSESQE 341
+ + +S DS ++K +N S ++D SS+S +E + + +S E ++
Sbjct: 323 HKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEK 382
Query: 342 EVVSESRGDNPDPTTSYVEDQED---------SDSSEEDSSHTLSHSKSESREEQADSES 392
E E S ED+E SD+ + DS S + +DSE
Sbjct: 383 EGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEE 442
Query: 393 SESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNS 452
S++ E + S S+ G + + A+ E EE++ + +E+
Sbjct: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGE 502
Query: 453 TESKSSSEED 462
T+ K + + D
Sbjct: 503 TQVKEAEDSD 512
Score = 60.1 bits (144), Expect = 5e-09
Identities = 66/268 (24%), Positives = 112/268 (41%), Gaps = 27/268 (10%)
Query: 253 RKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQE 312
R S EDD +E + V+ S ++ R+ GL P+ DS+ D NL+
Sbjct: 23 RDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGL--PKGHHVTDSENDEPLNLNAS 80
Query: 313 ESQNVD-GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV--EDQED----- 364
+S++ + +S E+ ++ +S+S+ E V++ D+ T + D E+
Sbjct: 81 DSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLN 140
Query: 365 ---SDSSEED-SSHTLSHSKSESREEQ--ADSESSESLN---FSEESPESPEDENSSSQE 415
SDS ED H S S+ E ++ +DSE+ ++L ES E P + S S+
Sbjct: 141 GHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSEN 200
Query: 416 GLQSHSSSAESQSEE--------SHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN 467
++S+SEE S SEE S ++E S S SE+ + +
Sbjct: 201 EEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQA 260
Query: 468 IEIESRKLTVDAYHNKPIGDQDDNDCQD 495
+ E+ +L + D N D
Sbjct: 261 SDSENEELPKPRISDSESEDPPRNQASD 288
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 98.2 bits (243), Expect = 2e-20
Identities = 96/484 (19%), Positives = 185/484 (38%), Gaps = 55/484 (11%)
Query: 23 QNNESEDSEE-WKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGK 81
+ E E +EE K H + + ++D +D + EG + G + +
Sbjct: 602 EEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAK---------SVGEAEDGPE 652
Query: 82 GGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDS 141
G D +E SG + + D++ G KD+ G R G E + +E+ + +D
Sbjct: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK-----ELAEKEEWKKRDG 707
Query: 142 AQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQS 201
+ E + ++R EGG+ EEH G G + E + E + EG +
Sbjct: 708 EEQEQKEREQGHQKERNQEMEEGGE-------EEH--GEGEEEEGDREEEEEKEGEGKEE 758
Query: 202 DDPESIRSERGNSRMNSAGMKSKESGENS--EQANTQDSGGSQLLEHPSRKIFRKSRISE 259
+ E + ER KE GE E+A ++ G + + + + R E
Sbjct: 759 GEGEEVEGER-----------EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEE 807
Query: 260 EDDRSELDDNNTME---EVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN 316
+++ E++ E E + + E + G + + +G+ +E+ E +EE +
Sbjct: 808 KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE---EEEGEGEEEEGEGKGEEEGEE 864
Query: 317 VDGPSSESSQEANLSSQENSSESQEE-----VVSESRGDNPDPTTSYVEDQEDSDSSEED 371
+G E +E E +EE E G+ + E++E EE+
Sbjct: 865 GEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEE 924
Query: 372 SSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEES 431
+ E EE+ + E + EE E E +EG E + EE
Sbjct: 925 G----EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE---EEEGEGEGEEEGEGEGEEG 977
Query: 432 HSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
E ++ + + +E E + EE+G+ + E E ++ + + G+ ++
Sbjct: 978 EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE 1037
Query: 492 DCQD 495
+ ++
Sbjct: 1038 EGEE 1041
Score = 87.8 bits (216), Expect = 2e-17
Identities = 85/461 (18%), Positives = 175/461 (37%), Gaps = 51/461 (11%)
Query: 26 ESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDD 85
E E E +GH + N++ + + E G G ++ G K G+
Sbjct: 709 EQEQKEREQGHQKER------NQEMEEGGEEEHGEGEEEE-------GDREEEEEKEGEG 755
Query: 86 KDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDT 145
K++ E G++ G+ + G + ++E +E+ D EE+ +G++ +
Sbjct: 756 KEEGE---GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812
Query: 146 TSESRELDNE--DRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 203
E E++ +R + + EG +E E EE +GE G+G ++EG + +
Sbjct: 813 EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEE----EGEGEEEEGEGKG-EEEGEEGEG 867
Query: 204 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 263
E G + +E GE + + G + E + + + EE +
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927
Query: 264 SELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSE 323
E + E + + E + G + +G+ +E E + E + +G
Sbjct: 928 GEGEGEEEEGEGEGEDGEGEGEEEEG------EWEGEEEEGEGEGEEEGEGEGEEGEGEG 981
Query: 324 SSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSES 383
+E +E E +EE E G E++ + + EE+ + E
Sbjct: 982 EEEEGEGEGEEE--EGEEEGEEEGEG----------EEEGEGEGEEEEEGEVEGEVEGEE 1029
Query: 384 REEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDS 443
E + + E E E E +EN ++E + + EE + +D + +
Sbjct: 1030 GEGEGEEEEGEE-EGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKV 1088
Query: 444 SR-------SKEDSNSTESKSSSEEDG--QLKNIEIESRKL 475
S+ K + +S ++++ +G Q + ++S++L
Sbjct: 1089 SKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQSKRL 1129
Score = 81.6 bits (200), Expect = 1e-15
Identities = 78/369 (21%), Positives = 134/369 (36%), Gaps = 53/369 (14%)
Query: 124 SDDTIQASEESAPQGQDSAQDTTSESRELD-NEDRVDSKPEGG-------------DSTQ 169
SD+ ++ EE +G + ++ E +E++ NE+ V K GG D +
Sbjct: 580 SDEEVEIPEEK--EGAEDSKGNGIEEQEVEANEENV--KVHGGRKEKTEILSDDLTDKAE 635
Query: 170 ESESEEHWVGGGSDGESSHGDGS----ELDDEGMQSDDPESIRSERGNSRMNSAGMKSKE 225
SE + VG DG GDG+ E Q ++ E ++G M G KE
Sbjct: 636 VSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695
Query: 226 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNS 285
E E K R EE ++ E + + E ++ E
Sbjct: 696 LAEKEEW---------------------KKRDGEEQEQKEREQGHQKE--RNQEMEEGGE 732
Query: 286 RDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS 345
+ G + + + +E E + E + V+G + E + E EE
Sbjct: 733 EEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGD 792
Query: 346 ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESP-- 403
+ G+ + T E++E+ E + K E EE+ + E E EE
Sbjct: 793 QGEGEEEE-TEGRGEEKEEGGEVEGGE---VEEGKGEREEEEEEGEGEEEEGEGEEEEGE 848
Query: 404 -ESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED 462
E E E +EG + E + E EE++ + + + + E + EE+
Sbjct: 849 GEEEEGEGKGEEEGEEGEGEE-EGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE 907
Query: 463 GQLKNIEIE 471
G+ + E E
Sbjct: 908 GEGEGEEEE 916
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 90.5 bits (223), Expect = 3e-18
Identities = 92/400 (23%), Positives = 156/400 (39%), Gaps = 22/400 (5%)
Query: 88 DDEDDSGDDTFGD-DDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTT 146
+D G F D + G G + + + ++G++E +DT Q +E + DS D
Sbjct: 4662 EDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIK 4721
Query: 147 SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGD--GSELD--DEGMQSD 202
E ++ + D K G+ ++ E +E G D + GD G E D DE + D
Sbjct: 4722 GEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGD 4781
Query: 203 DPESIRSERGNSRMNSAGM-KSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED 261
D E E +++ G +E E + + DSG S + K K +E D
Sbjct: 4782 DDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEE-AEAD 4840
Query: 262 DRSELDDNNTMEEVKSDSTENS----NSRDTGLSQPRR-DSKGDSQEDSKENLSQEESQN 316
D + +D + + D EN + + +P D D DS++ E++ N
Sbjct: 4841 DGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDN 4900
Query: 317 VDGPS------SESSQEANLSSQE--NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSS 368
+G E +EA ++E + Q E S + E +E+ D+
Sbjct: 4901 EEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTG 4960
Query: 369 EEDSSHTLSHSKSESREEQADSESSESLNFSEESPES-PEDENSSSQEGLQSHSSSAESQ 427
+D + E EEQ S + EE E+ P D+ QE + S E Q
Sbjct: 4961 ADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQ 5020
Query: 428 SEES-HSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLK 466
E+ +E S Q + +++ + E ++ E Q K
Sbjct: 5021 VPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGK 5060
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/502 (18%), Positives = 205/502 (40%), Gaps = 66/502 (13%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGK- 81
++N E SE++ G + E+ + + + G D +++ L G + +
Sbjct: 4723 EDNAIEMSEDFDGKMHDGEL-----EEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDER 4777
Query: 82 --GGDDKDDDEDDSGDDTFGDDDSGPG----------PKDRQEGGNSRLGSDEDS--DDT 127
G DD+++DE++ + T +++GPG D + GNS + ++
Sbjct: 4778 LWGDDDEEEDEEEEDNKT---EETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEK 4834
Query: 128 IQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS 187
+A + QG+D + E R+ D E+ VD + E E+ + D E
Sbjct: 4835 EEAEADDGGQGEDKINEQIDE-RDYD-ENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDK 4892
Query: 188 HGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDS------GGS 241
+G G + D+E + ++P I+ + AG +++E GE N S G S
Sbjct: 4893 NG-GEDTDNEEGEEENPLEIKE-----KPEEAGHEAEERGETETDQNESQSPQEPEEGPS 4946
Query: 242 QLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDS 301
+ + + ++ D ++ + ++ E+ +S ++ + + G D
Sbjct: 4947 EDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQP 5006
Query: 302 QEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVED 361
QE+ + S E Q + + + EN +Q ++ + + +
Sbjct: 5007 QEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSG 5066
Query: 362 QEDSDSSEEDSS----------HTLSHSKSESREE-QADSESS---------------ES 395
D++ +E S HT +++S R+ QAD+E S ++
Sbjct: 5067 AADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDT 5126
Query: 396 LNFSEESP-ESPED--ENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNS 452
+ +E+ P + P+ E++ + E ++ S + ++Q+ + S+E ++DS + +E+
Sbjct: 5127 DSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEI 5186
Query: 453 TESKSSSEEDGQLKNIEIESRK 474
++ +EE + K ++E K
Sbjct: 5187 EDTLMDTEEQEEFKAADVEQLK 5208
Score = 58.9 bits (141), Expect = 1e-08
Identities = 87/479 (18%), Positives = 166/479 (34%), Gaps = 76/479 (15%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPG 106
+E+ D+ E G G D+ +A + +G DK + + DD G G
Sbjct: 4787 DEEEEDNKTEETGPGMDEEDSEL-VAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQG 4845
Query: 107 PKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQ---------------DSAQDTTSESRE 151
E + R DE+ D ++E P+ + + +DT +E E
Sbjct: 4846 EDKINEQIDER-DYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGE 4904
Query: 152 LDNEDRVDSKPE---------GGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSD 202
+N + KPE G T ++ES+ E +G E D G
Sbjct: 4905 EENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQ 4964
Query: 203 DPESIR--SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE 260
D ++ + E + S K KE+ E + D G E + ++ E
Sbjct: 4965 DGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEA 5024
Query: 261 DDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGP 320
+R E + + + ++ +N+ + + + P ++ + + +Q E +
Sbjct: 5025 LERKE---HASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFI 5081
Query: 321 SSESSQEANLSSQENSSESQEEVVSE-SRGDNPD---------PTTSYVEDQ-------- 362
+ +SQ+ + ++ + +E S GD+ + T S+ E
Sbjct: 5082 AQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQ 5141
Query: 363 -EDSDSSE------------------EDSSHTLSHSKSESREEQA-----DSESSESLNF 398
ED+D+ E ++ + S + EE+ D+E E
Sbjct: 5142 VEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKA 5201
Query: 399 SEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKS 457
++ PE+ S + L E Q+ ++ E+D D + KE N +S
Sbjct: 5202 ADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVKT---EEDQDPRTDKAHKETENEKPERS 5257
Score = 48.5 bits (114), Expect = 1e-05
Identities = 38/189 (20%), Positives = 82/189 (43%), Gaps = 24/189 (12%)
Query: 301 SQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 360
++E ++ + + ++ + P S+S ++ ++N+ E E+ + +E
Sbjct: 4695 NEEQVEDTFQKGQEKDKEDPDSKS----DIKGEDNAIEMSEDFDGKMHDGE-------LE 4743
Query: 361 DQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSH 420
+QE+ D + L + E+AD +E + E++N + + G
Sbjct: 4744 EQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETG---- 4799
Query: 421 SSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED----GQLK-NIEIESR-- 473
+ + E +++D+ DS +S++ K + E K +E D G+ K N +I+ R
Sbjct: 4800 -PGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDY 4858
Query: 474 -KLTVDAYH 481
+ VD YH
Sbjct: 4859 DENEVDPYH 4867
Score = 43.9 bits (102), Expect = 3e-04
Identities = 41/193 (21%), Positives = 73/193 (37%), Gaps = 5/193 (2%)
Query: 303 EDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRG-DNPDPTT-SYVE 360
EDS + E G E ++S Q + E E+ + + D DP + S ++
Sbjct: 4662 EDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIK 4721
Query: 361 DQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSH 420
++++ ED + + E +EE + SE + + + +E E L
Sbjct: 4722 GEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGD 4781
Query: 421 SSSAESQSEESHSEEDDS---DSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTV 477
E + EE + E+ D +DS +D N S+ ++ Q K E E +
Sbjct: 4782 DDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADD 4841
Query: 478 DAYHNKPIGDQDD 490
I +Q D
Sbjct: 4842 GGQGEDKINEQID 4854
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 86.3 bits (212), Expect = 6e-17
Identities = 94/450 (20%), Positives = 182/450 (40%), Gaps = 43/450 (9%)
Query: 37 LAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDD 96
L +A +A E + SE GS+ + + G S GG +++ G+
Sbjct: 1760 LGEAEGDAMAQEREGKTHNSETSAGSELGE-AEQEGEGISERGETGGQGSGHEDNLQGEA 1818
Query: 97 TFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNED 156
G D PG D EG + + + + ++ AP+ + AQ+ E++ ++ED
Sbjct: 1819 AAGGDQD-PGQSDGAEGIEA---PEAEGEAQPESEGVEAPEAEGDAQEAEGEAQP-ESED 1873
Query: 157 RVDSKPEGGDSTQESES----EEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERG 212
V++ G++ ESE E W ES + E + E + G
Sbjct: 1874 -VEAPEAEGEAQPESEDVETPEAEWE---VQPESEGAEAPEAEKEAQPETESVEALETEG 1929
Query: 213 NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTM 272
S G +++E+ E +++A Q S+++E S+ +EE+ + E +D +
Sbjct: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE---------SQEAEEEAQPESEDVEAL 1980
Query: 273 E-EVKSDSTENSNSRDT-GLSQPRRDSKGDSQEDSKENLSQ------------EESQNVD 318
E EV++ E ++ + P +++G+ QE +E + EE+Q V+
Sbjct: 1981 EVEVETQEAEGEAQPESEDVEAP--EAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVE 2038
Query: 319 GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSH 378
G + ++ +A S + EE E+ G+ + + ED D+ E +
Sbjct: 2039 GETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPES 2098
Query: 379 SKSESREEQADSESSESLNFSEESPES-PEDENSSSQEG---LQSHSSSAESQSEESHSE 434
E+ E + +++ +E + E E+ PE E + E Q S E+Q E ++
Sbjct: 2099 EGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQ 2158
Query: 435 EDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 464
+ + +E E + E +G+
Sbjct: 2159 PESEGIEAQEAEEEAQPELEGVEAPEAEGE 2188
Score = 79.3 bits (194), Expect = 7e-15
Identities = 86/426 (20%), Positives = 176/426 (41%), Gaps = 66/426 (15%)
Query: 88 DDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTS 147
+ E +G + + G G +R E G G +++ A + P D A+
Sbjct: 1778 NSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-- 1835
Query: 148 ESRELDNEDRVDSK----PEGGDSTQESESEEHWVGGGSDGESSHGDGS----------- 192
E+ E + E + +S+ PE QE+E E + + G+
Sbjct: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895
Query: 193 --ELDDEGMQSDDPESIRSER------------GNSRMNSAGMKSKESGENSEQANTQDS 238
E+ E ++ PE+ + + G S G +++E+ E +++A Q
Sbjct: 1896 EWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQ 1955
Query: 239 GGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME-EVKSDSTE-NSNSRDTGLSQPRRD 296
S+++E S+ +EE+ + E +D +E EV++ E + + P +
Sbjct: 1956 PESEVIE---------SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAP--E 2004
Query: 297 SKGDSQEDSKENLSQ------------EESQNVDGPSSESSQEANLSSQENSSESQEEVV 344
++G+ QE +E + EE+Q V+G + ++ +A S + EE
Sbjct: 2005 AEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEA 2064
Query: 345 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 404
E+ G+ + + ED D+ E + E+ E + +++ +E + E+PE
Sbjct: 2065 QEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI----EAPE 2120
Query: 405 SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE-DG 463
+ E E EG+++ + E+Q E E D++ + ++ +S E++ + EE
Sbjct: 2121 T-EGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGE----AQPESEGIEAQEAEEEAQP 2175
Query: 464 QLKNIE 469
+L+ +E
Sbjct: 2176 ELEGVE 2181
Score = 77.0 bits (188), Expect = 4e-14
Identities = 89/396 (22%), Positives = 163/396 (41%), Gaps = 45/396 (11%)
Query: 104 GPGPKDRQEG-GNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRE-LDNEDRVDSK 161
GPG + ++G G+ RL D+D P+ ++ D ++ RE + +
Sbjct: 1737 GPGVDEGEDGEGSQRLNRDKD------------PKLGEAEGDAMAQEREGKTHNSETSAG 1784
Query: 162 PEGGDSTQESE--SEEHWVGGGSDGESSHGDGSEL---DDEGMQSDDPESIRSER--GNS 214
E G++ QE E SE GG G + G D + QSD E I + G +
Sbjct: 1785 SELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEA 1844
Query: 215 RMNSAGMKSKESGENSEQANTQDSGGSQLLEHP---------SRKIFRKSRISEEDDRSE 265
+ S G+++ E+ ++++A + S+ +E P S + E SE
Sbjct: 1845 QPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESE 1904
Query: 266 LDDNNTMEEVKSDSTENSNSRDT-GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSES 324
+ E+ TE+ + +T G +P +S+G ++++E + E Q
Sbjct: 1905 GAEAPEAEKEAQPETESVEALETEGEDEP--ESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962
Query: 325 SQEANLSSQENSSESQ--------EEVVSESRGDNPDPTTSYVED--QEDSDSSEEDSSH 374
SQEA +Q S + + +E E++ ++ D E QE + ++ +S
Sbjct: 1963 SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG 2022
Query: 375 TLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSE 434
+ KSE E Q + E + PES E ++E Q + E+H E
Sbjct: 2023 VEAQPKSEGEEAQ-EVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPE 2081
Query: 435 EDDSDSQDS-SRSKEDSNSTESKSSSEEDGQLKNIE 469
+D D+Q++ ++ +S E+ + E + + IE
Sbjct: 2082 SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
Score = 72.4 bits (176), Expect = 9e-13
Identities = 86/370 (23%), Positives = 160/370 (43%), Gaps = 46/370 (12%)
Query: 96 DTFGDDD---SGPGPKDRQEGGNSRLGSDEDSDDTIQ---ASEESAPQGQD-SAQDTTSE 148
+T G+D+ G ++ +E G + + I+ A EE+ P+ +D A + E
Sbjct: 1926 ETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVE 1985
Query: 149 SRELDNEDRVDSK----PEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDP 204
++E + E + +S+ PE QE+E E S G ++ EG ++ +
Sbjct: 1986 TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ--------PESDGVEAQPKSEGEEAQEV 2037
Query: 205 ES-IRSERGNSRMNSAGMKSKESGENSEQAN--TQDSGGSQLLEHPSRKIFRKSRISEED 261
E + G+++ S G+++ E+ E +++A Q++ G HP SE+
Sbjct: 2038 EGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEA---HPE---------SEDV 2085
Query: 262 DRSELDDNNTMEE--VKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDG 319
D E + E V++ E + G+ P +++G++Q +S E + E++
Sbjct: 2086 DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAP--ETEGEAQPES-EGIEAPEAEGEAQ 2142
Query: 320 PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS 379
P SE EA + E ES E + ++ + P VE E ++ + S +
Sbjct: 2143 PESEGV-EAQDAEGEAQPES-EGIEAQEAEEEAQPELEGVEAPE-AEGEAQPESEGIEAP 2199
Query: 380 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE---D 436
++E E Q + E E+ EE+ PE + EG S E+Q E+ S +
Sbjct: 2200 EAEG-EAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLG 2258
Query: 437 DSDSQDSSRS 446
D S+++S S
Sbjct: 2259 DGQSEEASES 2268
Score = 67.4 bits (163), Expect = 3e-11
Identities = 85/360 (23%), Positives = 145/360 (40%), Gaps = 63/360 (17%)
Query: 120 SDEDSDDTIQASEE------SAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESES 173
+D S T+Q +E S G D +D R ++D + EG QE E
Sbjct: 1715 TDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREG 1774
Query: 174 EEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQA 233
+ H S GSEL G + E I SERG + +G + GE +
Sbjct: 1775 KTH--------NSETSAGSEL---GEAEQEGEGI-SERGETGGQGSGHEDNLQGEAA--- 1819
Query: 234 NTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQP 293
+GG Q D + D +E +++ S G+ P
Sbjct: 1820 ----AGGDQ-------------------DPGQSDGAEGIEAPEAEGEAQPESE--GVEAP 1854
Query: 294 RRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD 353
+++GD+QE E +Q ES++V+ P +E + S + E++ EV ES G +
Sbjct: 1855 --EAEGDAQEAEGE--AQPESEDVEAPEAEGEAQPE-SEDVETPEAEWEVQPESEG--AE 1907
Query: 354 PTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSS 413
+ E Q +++S E + +SE E Q E+++ + PES E+ +
Sbjct: 1908 APEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAE-GQTQPESEVIESQEA 1966
Query: 414 QEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESR 473
+E Q S E+ E ++E + ++Q S E + E +G+++ E E++
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVE---------APEAEGEMQEAEEEAQ 2017
Score = 63.2 bits (152), Expect = 5e-10
Identities = 67/305 (21%), Positives = 116/305 (38%), Gaps = 18/305 (5%)
Query: 184 GESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL 243
GE + G+ +E+ G DP S R+ +G G+ + E D GSQ
Sbjct: 1698 GEHTDGEAAEVAP-GKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGE-----DGEGSQR 1751
Query: 244 LEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQE 303
L +R K +E D ++ + T S +E + G R G
Sbjct: 1752 L---NRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808
Query: 304 DSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEV----VSESRGDNPDPTTSYV 359
++NL E + D +S + + E E+Q E E+ GD +
Sbjct: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQ 1868
Query: 360 EDQEDSDSSEEDSSHTLSHSKSESREE----QADSESSESLNFSEESPESPEDENSSSQE 415
+ ED ++ E + E+ E Q +SE +E+ +E+ E + E
Sbjct: 1869 PESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETE 1928
Query: 416 GL-QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 474
G + S AE+Q E ++E + +Q S E + E ED + +E+E+++
Sbjct: 1929 GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE 1988
Query: 475 LTVDA 479
+A
Sbjct: 1989 AEGEA 1993
Score = 37.4 bits (85), Expect = 0.032
Identities = 38/178 (21%), Positives = 65/178 (36%), Gaps = 20/178 (11%)
Query: 259 EEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVD 318
E + + ++ +EE++ E L + + +G Q ++ E +EE +
Sbjct: 1343 ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEE 1402
Query: 319 G-----PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSS 373
G SE+S SQE+ +EE S P P E ++ E S
Sbjct: 1403 GSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPA-------EGTEEPTEPPS 1455
Query: 374 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEES 431
H LS + + E Q+ S+ L E P QE Q+ + ++ S
Sbjct: 1456 H-LSETDPSASERQSGSQLEPGL-------EKPPGATMMGQEHTQAQPTQGAAERSSS 1505
Score = 37.0 bits (84), Expect = 0.041
Identities = 122/554 (22%), Positives = 182/554 (32%), Gaps = 154/554 (27%)
Query: 41 PTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGD 100
PTPP P + S GS HQ S + G GG ++ G
Sbjct: 854 PTPPRGRPCPQRRSSSCGSTGSS-HQ---------STARGPGGSPQE-----------GT 892
Query: 101 DDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESA------PQGQDSAQDTTSESRELDN 154
GP P G SR S + SEE PQGQ+ A + S +
Sbjct: 893 RQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSS 952
Query: 155 EDRV-----DSKPE----------------------------GGDSTQESESEEHWVGG- 180
+ V D+ PE G D + E E G
Sbjct: 953 PEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQ 1012
Query: 181 ---GSDGESSHGDGSEL--DDEGMQSDD-------PESIR---SERGNSRMNSAGMK-SK 224
G G+ +G+ L D G QS + PE + +E G R AG + S
Sbjct: 1013 SLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSL 1072
Query: 225 ESGENSEQANTQ--------DSGGSQLLEHPSRKIFRKSRIS--------------EED- 261
+ A+TQ G + SR + R+ S EED
Sbjct: 1073 RALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDL 1132
Query: 262 ----DRSELDDNNTMEEVKSDSTE-------NSNSRDTGL-----SQPRRDSKGDSQEDS 305
+ D+ +E+ S S + + D+GL SQ D +
Sbjct: 1133 GSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMT-- 1190
Query: 306 KENLSQEESQNVD-----GPSSESS----QEANLSSQ------ENSSESQEEVVSESRGD 350
EN + S VD G S ESS + L +Q + S++ + ES GD
Sbjct: 1191 -ENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGD 1249
Query: 351 NPD------PT--------TSYVEDQEDSDSSEEDSSHTLSHSKSESREEQAD-SESSES 395
+ PT + ED+ + DS E+ +S L + +E+ E+ E
Sbjct: 1250 LENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEG 1309
Query: 396 LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTES 455
E+ + E + ++EGLQ E E E + Q+ E+ T
Sbjct: 1310 TEGEGLQEEAVQLEETKTEEGLQE-----EGVQLEETKETEGEGQQEEEAQLEEIEETGG 1364
Query: 456 KSSSEEDGQLKNIE 469
+ EE QL+ ++
Sbjct: 1365 EGLQEEGVQLEEVK 1378
Score = 32.0 bits (71), Expect = 1.3
Identities = 39/192 (20%), Positives = 68/192 (35%), Gaps = 23/192 (11%)
Query: 289 GLSQPRRDSKGDSQEDSKENLSQEESQNV---DGPSSESSQEANLSSQENSSESQEEVVS 345
GL P + + + S+E S + S + +G S + + + SQ+E +
Sbjct: 511 GLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQE--A 568
Query: 346 ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPES 405
GD P S + D +E T + + E S ++ E S
Sbjct: 569 SEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPL--VLGLSCSWDSEGASS 626
Query: 406 PEDENSSSQEGLQSHSSSAESQS----------------EESHSEEDDSDSQDSSRSKED 449
+SSQ+G + H S A + S SH +D DSS +K+
Sbjct: 627 TPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSVTKQV 686
Query: 450 SNSTESKSSSEE 461
E + + ++
Sbjct: 687 PRPPERRRACQD 698
Score = 31.2 bits (69), Expect = 2.3
Identities = 28/150 (18%), Positives = 61/150 (40%), Gaps = 7/150 (4%)
Query: 100 DDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVD 159
+D++ ++++ N ++ + +Q E + Q+ + E E+ +
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
Query: 160 SKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD----PE-SIRSERGNS 214
+ + T+E+E E E G L +EG+Q ++ PE ++ E
Sbjct: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
Query: 215 RMNSAGMKSKES--GENSEQANTQDSGGSQ 242
+ G+ + S G+ +A++ D GSQ
Sbjct: 1393 GLKEEGLPEEGSVHGQELSEASSPDGKGSQ 1422
Score = 30.4 bits (67), Expect = 3.9
Identities = 35/153 (22%), Positives = 57/153 (37%), Gaps = 29/153 (18%)
Query: 128 IQASEESAPQGQDSAQDTTSESRELDNE---------DRVDSKPEGG---DSTQESESEE 175
++ ++E+ +GQ + E E E + V PEGG ++ +E EE
Sbjct: 1338 LEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEE 1397
Query: 176 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANT 235
GS + S D +G Q DDP ++ +E+G S A
Sbjct: 1398 GLPEEGSVHGQELSEASSPDGKGSQEDDP----------------VQEEEAGRASASAEP 1441
Query: 236 QDSGGS-QLLEHPSRKIFRKSRISEEDDRSELD 267
+ G+ + E PS SE S+L+
Sbjct: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLE 1474
>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
[Homo sapiens]
Length = 666
Score = 85.1 bits (209), Expect = 1e-16
Identities = 86/373 (23%), Positives = 148/373 (39%), Gaps = 48/373 (12%)
Query: 51 SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGD----DTFGDDDSGPG 106
S++ + + GSD A G S G + D+ DSG + FGDD
Sbjct: 14 SEAERKDSDSGSDSDSDQENAASG---SNASGSESDQDERGDSGQPSNKELFGDD----- 65
Query: 107 PKDRQEGGNSRLGSD---EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDS-KP 162
EG + GSD E SD+ +ASE S + D + E N+D + +
Sbjct: 66 --SEDEGASHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRS 123
Query: 163 EGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 222
+GG E+E GS+ S + +D+ QSDD + S+ S K
Sbjct: 124 DGGSHHSEAE--------GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDK 175
Query: 223 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 282
+ S ++ + NT D QL + +++ + + + +D+R DN+ E
Sbjct: 176 LQNSDDDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDND---------DEK 226
Query: 283 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 342
NS D Q + K + +D + S EE ++ S + ++ + S S+S++E
Sbjct: 227 QNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRH----SDDEEEQDHKSESARGSDSEDE 282
Query: 343 VVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES 402
V+ R + S E D++ +++S ++ +D E +
Sbjct: 283 VLRMKR---KNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGED------KPPT 333
Query: 403 PESPEDENSSSQE 415
P P DEN Q+
Sbjct: 334 PGQPVDENGLPQD 346
Score = 84.7 bits (208), Expect = 2e-16
Identities = 87/401 (21%), Positives = 157/401 (39%), Gaps = 54/401 (13%)
Query: 95 DDTFGDD-DSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELD 153
+D FG D DS KD S GSD DSD AS +A G +S QD +S +
Sbjct: 5 EDLFGSDADSEAERKD------SDSGSDSDSDQENAASGSNA-SGSESDQDERGDSGQPS 57
Query: 154 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN 213
N++ E ++ S S+ H S+ + + SE D + +DP + G+
Sbjct: 58 NKELFGDDSEDEGASHHSGSDNH-----SERSDNRSEASERSDH--EDNDPSDVDQHSGS 110
Query: 214 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME 273
E+ + E + GGS E +E +++ DD
Sbjct: 111 -----------EAPNDDEDEGHRSDGGSHHSE------------AEGSEKAHSDDEKWGR 147
Query: 274 EVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQ 333
E KSD +++ +++ + + S D ++S ++ + + + + P + LS +
Sbjct: 148 EDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDDEKMQNTDDEERPQLSDDERQQLSEE 207
Query: 334 ENSSESQEEVVS-------ESRGDNPDPTTSYVEDQEDSD-----SSEEDSSHTLSHSKS 381
E ++ E V+ ++ D P S E ++SD +S+E+ H+ +
Sbjct: 208 EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQ 267
Query: 382 ESREEQADSESSES--LNFSEESPESPEDENSSSQEGLQSHSSSAE--SQSEESHSEEDD 437
+ + E A SE L ++ + + E S E + +S + + +++ S D
Sbjct: 268 DHKSESARGSDSEDEVLRMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDG 327
Query: 438 SDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 478
D + D N EE IE+E K+ D
Sbjct: 328 EDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEIPKVNTD 368
Score = 66.6 bits (161), Expect = 5e-11
Identities = 52/198 (26%), Positives = 95/198 (47%), Gaps = 29/198 (14%)
Query: 310 SQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSE 369
S+ E ++ D S S + N +S N+S S+ + + RGD+ P+ ++ DS +
Sbjct: 14 SEAERKDSDSGSDSDSDQENAASGSNASGSESD--QDERGDSGQPSN---KELFGDDSED 68
Query: 370 EDSSHTLSHSKSESREEQAD--SESSESLNFSE------------ESPESPEDENSSSQE 415
E +SH HS S++ E++D SE+SE + + E+P EDE S
Sbjct: 69 EGASH---HSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDG 125
Query: 416 GLQSHSSSAESQSEESHSEEDDSDSQDSSRSKED----SNSTESKSSSEEDGQLKNIEIE 471
G SH S AE SE++HS+++ +D S +D ++ E ++ ++ +L+N + +
Sbjct: 126 G--SHHSEAEG-SEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182
Query: 472 SRKLTVDAYHNKPIGDQD 489
+ D + D +
Sbjct: 183 EKMQNTDDEERPQLSDDE 200
Score = 55.8 bits (133), Expect = 9e-08
Identities = 66/318 (20%), Positives = 118/318 (37%), Gaps = 73/318 (22%)
Query: 27 SEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDH-QYIYRLAGGFSRSTGKGGDD 85
SE ++ +G Q L +D D S GSD+H + + RS + D
Sbjct: 43 SESDQDERGDSGQPSNKELFGDDSEDEGASHHS-GSDNHSERSDNRSEASERSDHEDNDP 101
Query: 86 KD-----------DDEDDS-------------GDDTFGDDDSGPGPKDRQEGGNSRLGSD 121
D DDED+ G + DD G +D+ + + +
Sbjct: 102 SDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQN 161
Query: 122 EDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGG 181
D ++ Q S+E Q D + + + D+E+R P+ D ++ SEE
Sbjct: 162 SDDEERAQGSDEDKLQNSDDDE----KMQNTDDEER----PQLSDDERQQLSEE------ 207
Query: 182 SDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGS 241
E SDD + S+ + + NS + + + + N+ D
Sbjct: 208 ---------------EKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEKMQNSDD---- 248
Query: 242 QLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS-KGD 300
+ + S+E+ R D+ ++ KS+S S+S D L R+++ D
Sbjct: 249 -----------ERPQASDEEHRH--SDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASD 295
Query: 301 SQEDSKENLSQEESQNVD 318
S+ DS + ++ S +D
Sbjct: 296 SEADSDTEVPKDNSGTMD 313
Score = 38.9 bits (89), Expect = 0.011
Identities = 103/531 (19%), Positives = 191/531 (35%), Gaps = 130/531 (24%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
++E+E SE+ A + ED SD + E+ SDD + R G
Sbjct: 129 HSEAEGSEK-----AHSDDEKWGREDKSDQSDDEKIQNSDDEE---RAQGSDEDKLQNSD 180
Query: 84 DDK-----DDDE-----DD-----SGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDS---- 124
DD+ DD+E DD S ++ DD P D + + SD++
Sbjct: 181 DDEKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDD---EKQNSDDEEQPQL 237
Query: 125 --DDTIQASEESAPQGQDSA---------QDTTSES-RELDNEDRV-----------DSK 161
++ +Q S++ PQ D QD SES R D+ED V DS+
Sbjct: 238 SDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSE 297
Query: 162 PEGGDSTQESESEEHWVGGGSDGESSHGDGSE--------LDDEGMQSDDPES------- 206
+ + S + GG+D SS DG + +D+ G+ D E
Sbjct: 298 ADSDTEVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETR 357
Query: 207 -------IRSERGNSR--MNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFR---- 253
+ ++ GN + S E Q + ++L+ R +
Sbjct: 358 IEVEIPKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRLKLKVE 417
Query: 254 ---KSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLS 310
+ RI +++ +E+ ++N SD + + + + + +GD +
Sbjct: 418 NTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHNHLFIRQGT 477
Query: 311 QEESQNV---------DGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD-PTTSYVE 360
+ Q V S + ++ LS + S++Q+ + G +P+ T ++
Sbjct: 478 GLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIK 537
Query: 361 DQEDSDSS------------EEDSSHTLSHSKSESREEQADSESSESLN----------- 397
+E+ + E+ LS S E + E ES++
Sbjct: 538 KEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGEESISLAAIKNRYKGG 597
Query: 398 --------FSEESPESPEDENSSSQEGLQSHSSSAESQSEES---HSEEDD 437
+S +S E E++ + Q L++ +++ + E S +E+DD
Sbjct: 598 IREERARIYSSDSDEGSEEDKA--QRLLKAKKLTSDEEGEPSGKRKAEDDD 646
Score = 38.1 bits (87), Expect = 0.019
Identities = 35/138 (25%), Positives = 53/138 (38%), Gaps = 17/138 (12%)
Query: 361 DQEDSDSSEEDSSHTL--SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 418
D ED S+ DS S S S+S +Q ++ S + + SE + D S + L
Sbjct: 3 DMEDLFGSDADSEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELF 62
Query: 419 SHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 478
S E S S S D+ + D+ S S+ S ED +++ S
Sbjct: 63 GDDSEDEGASHHSGS--------DNHSERSDNRSEASERSDHEDNDPSDVDQHSGS---- 110
Query: 479 AYHNKPIGDQDDNDCQDG 496
P D+D+ DG
Sbjct: 111 ---EAPNDDEDEGHRSDG 125
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 80.5 bits (197), Expect = 3e-15
Identities = 68/266 (25%), Positives = 120/266 (45%), Gaps = 28/266 (10%)
Query: 211 RGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNN 270
RG R+ S +K KE + + S G Q PS + + EED+ SE + +
Sbjct: 954 RGAIRLPSFKVKRKEPPDTT-------SSGDQKRLRPS------TSVDEEDEESERERDR 1000
Query: 271 TMEEVKSDSTENSNSRDTGLSQPRRDSKGDS--QEDSKENLSQEESQNVDGPSSESSQEA 328
M + + + +P R + DS +ED KE+LS+E+ + +E +E
Sbjct: 1001 DMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEE- 1059
Query: 329 NLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQA 388
+E+ + + ES D+ D S ++++ DS EE++ ++ SK+E+
Sbjct: 1060 ----EEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVT-SKAEATSSSE 1114
Query: 389 DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED--DSDSQDSSRS 446
SESSE + SE SP S EDE E + + E + EE +EE + +D +
Sbjct: 1115 SSESSEFESSSESSPSSSEDE-----EEVVAREEEEEEEEEEMVAEESMASAGPEDFEQD 1169
Query: 447 KEDSNSTESKSSSEEDGQLKNIEIES 472
E++ + + G + ++IE+
Sbjct: 1170 GEEAALAPGAPAVDSLGMEEEVDIET 1195
Score = 45.4 bits (106), Expect = 1e-04
Identities = 58/292 (19%), Positives = 107/292 (36%), Gaps = 45/292 (15%)
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRL---------GSDEDSDDTIQASEES 134
D++D++ + D D +D + G R G +ED +++ +ES
Sbjct: 988 DEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQES 1047
Query: 135 APQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSEL 194
+ +++ ++ E + D+ D D + T SE+ E
Sbjct: 1048 TEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASE------------------- 1088
Query: 195 DDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRK 254
DEG SD+ E++ + S S ES E+SE ++ +S S ++ +
Sbjct: 1089 KDEG-DSDEEETVSIVTSKAEATS----SSESSESSEFESSSESSPSS--SEDEEEVVAR 1141
Query: 255 SRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQE---DSKENLSQ 311
EE++ + + + D ++ P DS G +E +++ +
Sbjct: 1142 EEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPE 1201
Query: 312 EESQNVDGPSSESSQEANLSSQENSSE---SQEEVVSESRGDNPDPTTSYVE 360
E +D P E S+E E SQE + S P+P VE
Sbjct: 1202 ERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLS----PEPPAKEVE 1249
Score = 45.1 bits (105), Expect = 2e-04
Identities = 49/224 (21%), Positives = 90/224 (40%), Gaps = 16/224 (7%)
Query: 196 DEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKS 255
D G + D+ ES+ E+ ++ + +E+ E E+ + D E +
Sbjct: 1030 DSGGEEDEKESLSEEQESTE------EEEEAEEEEEEEDDDDDDSDDRDESENDDEDTAL 1083
Query: 256 RISEEDDRSELDDNNTMEEV--KSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEE 313
+ E D + D+ T+ V K+++T +S S ++ + +S S ED +E +++EE
Sbjct: 1084 SEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREE 1143
Query: 314 SQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDP--TTSYVEDQEDSDSSEED 371
+ + + + + E+ + EE D V+ + ++ + EE
Sbjct: 1144 EEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEER 1203
Query: 372 SSHTLSHSKSESREEQADS-ESSESLNFSEE-----SPESPEDE 409
S EE ADS E E S+E SPE P E
Sbjct: 1204 PSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKE 1247
Score = 41.6 bits (96), Expect = 0.002
Identities = 62/284 (21%), Positives = 102/284 (35%), Gaps = 42/284 (14%)
Query: 18 PVTRYQNNESEDSEEWKGHLAQAPTPPLANEDPSD---------STQSEEGLGSDDHQYI 68
P T + E E +A P LA DP + + G D+ + +
Sbjct: 983 PSTSVDEEDEESERERDRDMADTPCE-LAKRDPKGVGVRRRPARPLELDSGGEEDEKESL 1041
Query: 69 YRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTI 128
ST + + ++++E++ D DDDS DR E S+ D +DT
Sbjct: 1042 SEE----QESTEEEEEAEEEEEEEDDD----DDDS----DDRDE-------SENDDEDTA 1082
Query: 129 QASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH 188
+ +G ++T S V SK E S++ SES E S SS
Sbjct: 1083 LSEASEKDEGDSDEEETVS---------IVTSKAEATSSSESSESSEFESSSESSPSSSE 1133
Query: 189 GDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPS 248
+ + E + ++ E + +E M SAG + E + E A + L
Sbjct: 1134 DEEEVVAREEEEEEEEEEMVAEES---MASAGPEDFEQ-DGEEAALAPGAPAVDSLGMEE 1189
Query: 249 RKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQ 292
++ E+ S LD+ V+ + + GLSQ
Sbjct: 1190 EVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQ 1233
Score = 41.2 bits (95), Expect = 0.002
Identities = 44/200 (22%), Positives = 84/200 (42%), Gaps = 30/200 (15%)
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
DD DD D+S +D D+D+ ++ G+ SDE+ +I S+ A +S++
Sbjct: 1065 DDDSDDRDESEND---DEDTALSEASEKDEGD----SDEEETVSIVTSKAEATSSSESSE 1117
Query: 144 DT-------TSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSEL-- 194
+ +S S D E+ V + E + +E +EE G + G+ + L
Sbjct: 1118 SSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAP 1177
Query: 195 -----DDEGMQSD---DPESIRSERGNSRMNSAGM-----KSKESGENSEQANTQDSGGS 241
D GM+ + + E++ E S ++ + + +S E E+ G
Sbjct: 1178 GAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAM 1237
Query: 242 QLL-EHPSRKIFRKSRISEE 260
L E P++++ + +S E
Sbjct: 1238 LLSPEPPAKEVEARPPLSPE 1257
>gi|60097902 filaggrin [Homo sapiens]
Length = 4061
Score = 79.3 bits (194), Expect = 7e-15
Identities = 101/466 (21%), Positives = 168/466 (36%), Gaps = 45/466 (9%)
Query: 70 RLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQE------GGNS------- 116
R +G + S + D + E+ G GP + QE GG S
Sbjct: 1059 RDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDWSGGRSGRSGSFI 1118
Query: 117 -RLGSDEDSDDTIQASEESAPQGQDS----AQDTTSESRELDNEDRVDSKP---EGG--- 165
++ + E S+ + S + Q S A+D++ S + +D + + P GG
Sbjct: 1119 YQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQG 1178
Query: 166 -------DSTQESESEEHWVGGGSDGESSHGD-GSELDDEGMQSDDPESIRSERGNSRMN 217
D + S S ++SHG GS + D S SR +
Sbjct: 1179 SHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQSGDGSRHSGSRHH 1238
Query: 218 SAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKS 277
A + S + Q + S GS+ H + + S D SE +
Sbjct: 1239 EAASWADSSRHS--QVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHG 1296
Query: 278 DSTENSN--SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQEN 335
S E S SR G Q R S G S + S+++ + + G + S ++A S E
Sbjct: 1297 SSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGER 1356
Query: 336 SSESQEEVVSESR--GDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSK-SESREEQADSES 392
++ SR G +S V D SS +++ HS+ S+++ A ++
Sbjct: 1357 HGSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQA 1416
Query: 393 SESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDS-QDSSRSKEDSN 451
+ES E+S SS E QSE +H + S + SR ++ N
Sbjct: 1417 GPHQQSHKESARGQSGESSGRSRSFLYQVSSHE-QSESTHGQTAPSTGGRQGSRHEQARN 1475
Query: 452 STESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY 497
S+ +S + ++ SR +YH + + D GY
Sbjct: 1476 SSRHSASQDGQDTIRGHPGSSRGGRQGSYHEQSV----DRSGHSGY 1517
Score = 77.8 bits (190), Expect = 2e-14
Identities = 97/437 (22%), Positives = 155/437 (35%), Gaps = 29/437 (6%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPG 106
+E S+ ++ S +H Y A SR + +D G SG
Sbjct: 1600 SEGHSEDSERRSESASRNH---YGSAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTR 1656
Query: 107 PKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGD 166
+ GG + ++ + Q DS+ D+ + R+ D+ DS G
Sbjct: 1657 HAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTGRRQ-DSSVVGDSGNRGSS 1715
Query: 167 STQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAG----MK 222
+Q S+SE H + S+HG Q ES R + G S +
Sbjct: 1716 GSQASDSEGHSEESDTQSVSAHGQAGP-----HQQSHQESTRGQSGERSGRSGSFLYQVS 1770
Query: 223 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE----------DDRSELDDNNTM 272
+ E E++ +GG Q H + + S+E R ++
Sbjct: 1771 THEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHYE 1830
Query: 273 EEVKSDSTENSNSRDTGLSQPRRD-SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLS 331
+ V S S+ T SQ R D S+G S S ++ E Q+ DG S+ S
Sbjct: 1831 QSVDSSGHSGSHHSHT-TSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRHHEAS 1889
Query: 332 SQENSSESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDS---SHTLSHSKSESREEQ 387
S+ +SS + +S G S V DS EDS S + S + S EQ
Sbjct: 1890 SRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHLGSAWEQ 1949
Query: 388 ADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSK 447
+ S + E+ +SS Q G + SS+ Q+ SH + S +
Sbjct: 1950 SRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQARSSAGERHGSHH 2009
Query: 448 EDSNSTESKSSSEEDGQ 464
+ ++ S+ S GQ
Sbjct: 2010 QLQSADSSRHSGIGHGQ 2026
Score = 75.5 bits (184), Expect = 1e-13
Identities = 105/449 (23%), Positives = 163/449 (36%), Gaps = 43/449 (9%)
Query: 27 SEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDK 86
SEDSE W G ++ N S QS +G + R G S + + +
Sbjct: 631 SEDSERWSGSASR-------NHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTR 683
Query: 87 DDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDS-------DDTIQASEESAPQGQ 139
SG + + +R G +L S + S A +S +G
Sbjct: 684 HTQNSSSGQAASSHEQARSSAGERH-GSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGS 742
Query: 140 DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGM 199
+Q T SE D++ + S Q+S E GE S GS L
Sbjct: 743 SGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQES---ARDRSGERSRRSGSFLYQVST 799
Query: 200 QSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISE 259
ES G S G +++ +NS + +QD G + HP R+ R
Sbjct: 800 HKQS-ESSHGWTGPSTGVRQGSHHEQARDNSRHSASQD-GQDTIRGHPGSS--RRGRQGS 855
Query: 260 EDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD-SKGDSQEDSKENLSQEESQNVD 318
++S +D +S + + +S T SQ R D S+G S S ++ E Q+ D
Sbjct: 856 HHEQS-VD--------RSGHSGSHHSHTT--SQGRSDASRGQSGSRSASRTTRNEEQSRD 904
Query: 319 GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDS---SH 374
G S+ SS + S + +S G S V DS+ EDS S
Sbjct: 905 GSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSG 964
Query: 375 TLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSE 434
+ S + S +EQ+ S + E+ +SS Q G +S+ Q+ SH +
Sbjct: 965 SASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQ 1024
Query: 435 EDDSDSQDSSRSKEDSNSTESKSSSEEDG 463
++ S + S +S SS G
Sbjct: 1025 -----ARSSPGERHGSRHQQSADSSRHSG 1048
Score = 74.7 bits (182), Expect = 2e-13
Identities = 104/485 (21%), Positives = 173/485 (35%), Gaps = 36/485 (7%)
Query: 21 RYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTG 80
R SEDSE G ++ N S QS +G R + G S +
Sbjct: 301 RDSEGHSEDSERHSGSASR-------NHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSS 353
Query: 81 KGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAP---- 136
+ + + G + + P +R G+ + T + SA
Sbjct: 354 RQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRG 413
Query: 137 -QGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELD 195
+G +Q + SE +N D G ++ +E G GE S GS L
Sbjct: 414 HRGSSGSQASDSEGHS-ENSDTQSVSGHGKAGLRQQSHQEST--RGRSGERSGRSGSSLY 470
Query: 196 DEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKS 255
+ P+S G S G +++ ++S + +Q+ G + HP S
Sbjct: 471 QVSTH-EQPDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQE-GQDTIRGHPG-----SS 523
Query: 256 RISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD-SKGDSQEDSKENLSQEES 314
R + E N +S + + +S T SQ R D S G S S ++ E
Sbjct: 524 RGGRQGSHHEQSVN------RSGHSGSHHSHTT--SQGRSDASHGQSGSRSASRQTRNEE 575
Query: 315 QNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDS- 372
Q+ DG S+ SSQ +SS + +S G S V DS EDS
Sbjct: 576 QSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSE 635
Query: 373 --SHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEE 430
S + S + S +EQ+ S + E+ +SS + G + +S+ Q+
Sbjct: 636 RWSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAAS 695
Query: 431 SHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN-IEIESRKLTVDAYHNKPIGDQD 489
SH + S + + ++ S+ S GQ + + + + + G +
Sbjct: 696 SHEQARSSAGERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSE 755
Query: 490 DNDCQ 494
D+D Q
Sbjct: 756 DSDTQ 760
Score = 74.3 bits (181), Expect = 2e-13
Identities = 104/458 (22%), Positives = 169/458 (36%), Gaps = 40/458 (8%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQ-YIYRLAGGFSRSTGK 81
Q + E S + GH + ++ SD+++ + G S + Y +G SR +G
Sbjct: 2150 QGSHQEQSVDRSGHSGSHHSHT-TSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGS 2208
Query: 82 GGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDED--SDDTIQASEESAPQGQ 139
+ D S G S R G + SD + S+D+ + S ++
Sbjct: 2209 HHHEASSWADSSRHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHH 2268
Query: 140 DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGE--SSHGDGSELDDE 197
SAQ+ + + D G + +S H S G+ SSH E
Sbjct: 2269 GSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGE 2328
Query: 198 GMQSDDPESIRSER----GNSRMNSAGMKSKESGENSEQAN-----TQDSGGSQLLEH-- 246
S +S S R G+ + +SA S G + QA+ ++DS + H
Sbjct: 2329 RHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQ 2388
Query: 247 --PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ-- 302
P ++ ++S RS + + + +E+++ R TG S R Q
Sbjct: 2389 AGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGR-TGTSTGGRQGSHHKQAR 2447
Query: 303 EDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQ 362
+ S+ + SQE + G SS ++ S Q S G + TTS
Sbjct: 2448 DSSRHSTSQEGQDTIHGHPGSSS-----GGRQGSHYEQLVDRSGHSGSHHSHTTS----- 2497
Query: 363 EDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFS---EESPESPEDENSSSQEGLQS 419
D+SH S S+S SR+ + D +S + S S D + SQ G Q
Sbjct: 2498 ----QGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQVG-QG 2552
Query: 420 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKS 457
S + S DSDSQ S E + + S++
Sbjct: 2553 QSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRN 2590
Score = 72.8 bits (177), Expect = 7e-13
Identities = 106/447 (23%), Positives = 162/447 (36%), Gaps = 41/447 (9%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGP- 105
++ S S S+ SDD + RL+G SR+ G ++ D S F +D
Sbjct: 1265 HQGSSVSQDSDSERHSDDSE---RLSGSASRN--HHGSSREQSRDGSRHPGFHQEDRASH 1319
Query: 106 ---GPKDRQEGGNSRLGSDEDSDDTIQASEESAP---------QGQDSAQDTTSESRELD 153
RQ G + S + S+P Q DS++ + R+
Sbjct: 1320 GHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQAS 1379
Query: 154 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN 213
+ R DS G +Q + SE H + S+HG +S +S S G
Sbjct: 1380 SAVR-DSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESS-GR 1437
Query: 214 SRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP-SRKIFRKSRISEEDDR-------SE 265
SR + S E E++ +GG Q H +R R S + D S
Sbjct: 1438 SRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSR 1497
Query: 266 LDDNNTMEEVKSDSTENSNSRDTGLS-QPRRD-SKGDSQEDSKENLSQEESQNVDGPSSE 323
+ E D + +S + + Q R D S G S S ++ E Q+ DG
Sbjct: 1498 GGRQGSYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHS 1557
Query: 324 SSQEANLSSQENSSESQEEVVSESRGDNPDPTT-SYVEDQEDSDSSEEDS---SHTLSHS 379
S+ S++ SS + ES G S V DS+ EDS S + S +
Sbjct: 1558 GSRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRN 1617
Query: 380 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ-------SHSSSAESQSEESH 432
S EQ+ S + E+ SS Q G + ++S++ Q+ S
Sbjct: 1618 HYGSAREQSRHGSRNPRSHQEDRASHGHSAESSRQSGTRHAETSSGGQAASSQEQARSSP 1677
Query: 433 SEEDDSDSQDSSRSKEDSNSTESKSSS 459
E S Q S+ S DS + + SS
Sbjct: 1678 GERHGSRHQQSADSSTDSGTGRRQDSS 1704
Score = 72.4 bits (176), Expect = 9e-13
Identities = 107/490 (21%), Positives = 182/490 (37%), Gaps = 59/490 (12%)
Query: 27 SEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDK 86
SEDSE W G ++ N S QS G + R G S + +
Sbjct: 3225 SEDSERWSGSASR-------NHRGSVQEQSRHGSRHPRSHHEDRAGHGHSADRSRQSGTR 3277
Query: 87 DDDEDDSGDDTFGDDDSGPGPKDR-----QEGGNSRLGSDEDSDDTIQASEESAPQGQDS 141
+ G + + P +R Q+ +S S A +S G
Sbjct: 3278 HAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSG 3337
Query: 142 AQDTTSESRELDNEDR-VDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQ 200
+Q + SE +++ + V + G Q + GG G S GS L Q
Sbjct: 3338 SQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRS----GSFL----YQ 3389
Query: 201 SDDPESIRSERGNSRMNSAGMKSK--ESGENSEQANTQDSGGSQLLEHP--SRKIFRKSR 256
E S G +R ++ + E +S + + G + HP SR+ + S
Sbjct: 3390 VSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSH 3449
Query: 257 ISEEDDRSELDDNN---TMEEVKSDSTENSNSRDTGLSQPRRDSK-GD------------ 300
+ DRS ++ T + +SD++ + + Q R D + GD
Sbjct: 3450 YEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEA 3509
Query: 301 -SQEDSKENLSQEESQNVDGPSSESSQEANLS----SQENSSESQEEVVSESRG------ 349
+Q DS + + Q+ GP + +Q +++S SQ +S +S+ S SR
Sbjct: 3510 STQADSSRHSQSGQGQSA-GPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQ 3568
Query: 350 ----DNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPES 405
D TS+ ED+ S E S + +H S QA S ++ + + E S
Sbjct: 3569 EQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGS 3628
Query: 406 PEDENS-SSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 464
+++ SS+ H ++ + + H S + DS EDS+ T+S S+ + G
Sbjct: 3629 HHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSD-TQSVSAHGQAGP 3687
Query: 465 LKNIEIESRK 474
+ ES +
Sbjct: 3688 HQQSHQESTR 3697
Score = 72.0 bits (175), Expect = 1e-12
Identities = 100/492 (20%), Positives = 185/492 (37%), Gaps = 81/492 (16%)
Query: 30 SEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDD 89
S+E + + P S QS + G + + + G S ++ +
Sbjct: 1158 SQEGQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSAS 1217
Query: 90 EDDSGDDTFGDDDSGPGPKDRQEGG------NSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
D GD G + + +S++G ++ S S S QG +Q
Sbjct: 1218 RQTRKDKQSGDGSRHSGSRHHEAASWADSSRHSQVGQEQSS-----GSRTSRHQGSSVSQ 1272
Query: 144 DTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGSDGESSHGDGS-------- 192
D+ SE R D+ +R+ S+ G S ++S G + +SHG +
Sbjct: 1273 DSDSE-RHSDDSERLSGSASRNHHGSSREQSRDGSRHPGFHQEDRASHGHSADSSRQSGT 1331
Query: 193 ---ELDDEGMQSDDPESIRS---ERGNSRMNSAGMKSKESGENSEQANT--QDSGGSQLL 244
E G E RS ER SR + S+ SG QA++ +DSG
Sbjct: 1332 HHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSG----- 1386
Query: 245 EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQED 304
+ S+++ + SE D ++ + +++ Q +S G S+
Sbjct: 1387 ----HRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSG-ESSGRSRSF 1441
Query: 305 SKENLSQEESQNVDGPSSESS--------QEANLSSQENSSESQEEVV----SESRGDNP 352
+ S E+S++ G ++ S+ ++A SS+ ++S+ ++ + SRG
Sbjct: 1442 LYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSRGGRQ 1501
Query: 353 DPTTSYVEDQED------------SDSSEEDSSHTLSHSKSESREEQADSESSESLNFSE 400
SY E D + D+SH S +S SR+ + + +S + S
Sbjct: 1502 G---SYHEQSVDRSGHSGYHHSHTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSG 1558
Query: 401 ESPESP-------------EDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSK 447
P + E++ S+ + SS ++ + E HSE+ + S+ +SR+
Sbjct: 1559 SRHHEPSTRAGSSRHSQVGQGESAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNH 1618
Query: 448 EDSNSTESKSSS 459
S +S+ S
Sbjct: 1619 YGSAREQSRHGS 1630
Score = 71.6 bits (174), Expect = 2e-12
Identities = 101/450 (22%), Positives = 164/450 (36%), Gaps = 45/450 (10%)
Query: 27 SEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDK 86
SEDSE W G ++ N S QS +G + R G S + + +
Sbjct: 1928 SEDSERWSGSASR-------NHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTR 1980
Query: 87 DDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDS-------DDTIQASEESAPQGQ 139
+ G + + +R G + +L S + S A +S +G
Sbjct: 1981 HTESSSRGQAASSHEQARSSAGERH-GSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGY 2039
Query: 140 DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGM 199
+Q + SE D++ + S Q+S E G GESS GS L
Sbjct: 2040 SGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSHKES---ARGQSGESSGRSGSFL----Y 2092
Query: 200 QSDDPESIRSERGNSRMNSAGMKSK--ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRI 257
Q E S G S ++ G + + ++S + + G + HP R R
Sbjct: 2093 QVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPS--RGGRQ 2150
Query: 258 SEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD-SKGDSQEDSKENLSQEESQN 316
++S +D +S + + +S T SQ R D S+G S S + ++ Q+
Sbjct: 2151 GSHQEQS-VD--------RSGHSGSHHSHTT--SQGRSDASRGQSGSRSASRKTYDKEQS 2199
Query: 317 VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD---PTTSYVEDQEDSDSSEEDSS 373
DG S SS +SS + +V + + P P S V DS+ EDS
Sbjct: 2200 GDGSRHSGSHHHEASSWADSS--RHSLVGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSE 2257
Query: 374 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHS 433
S S S + A +S + E S++ QS + AE+ S +
Sbjct: 2258 RR-SGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAEN-SSGGQA 2315
Query: 434 EEDDSDSQDSSRSKEDSNSTESKSSSEEDG 463
++ S+ + S+ +S SS G
Sbjct: 2316 ASSHEQARSSAGERHGSHHQQSADSSRHSG 2345
Score = 71.6 bits (174), Expect = 2e-12
Identities = 103/509 (20%), Positives = 186/509 (36%), Gaps = 61/509 (11%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIY-RLAGGFSRSTGK 81
Q + E S + GH + ++ SD+++ + G S Q +G SR +
Sbjct: 3446 QGSHYEQSVDRSGHSGSHHSHT-TSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWS 3504
Query: 82 GGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDED--SDDTIQASEESAPQGQ 139
+ D S G S R +G + SD S+D+ + S ++ +
Sbjct: 3505 HHHEASTQADSSRHSQSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHR 3564
Query: 140 DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGE--SSHGDGSELDDE 197
SAQ+ + + D G + +S H S G+ SSH E
Sbjct: 3565 GSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGE 3624
Query: 198 GMQSDDPESIRSER----GNSRMNSAGMKSKESGENSEQAN-----TQDSGGSQLLEH-- 246
S +S S R G+ + +SA S G + QA+ ++DS + H
Sbjct: 3625 RHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQ 3684
Query: 247 --PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQED 304
P ++ ++S RS + + + +E+++ R + R+ S+ + D
Sbjct: 3685 AGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRHEQARD 3744
Query: 305 SKENLSQEESQN---------------------VDGPSSESSQEANLSSQENS------- 336
S + + +E Q+ VD S ++ +SQ S
Sbjct: 3745 SSRHSASQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQGRSDASHGQS 3804
Query: 337 ---SESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESS 393
S S+E E GD + S + S++ DSS + ES +
Sbjct: 3805 GSRSASRETRNEEQSGDGSRHSGS----RHHEASTQADSSRHSQSGQGESAGSRRSRRQG 3860
Query: 394 ESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNST 453
S++ +S PED S+ ++H S+ QS + S S +D++ + S
Sbjct: 3861 SSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDG-SRHPGSSHRDTASHVQSSPVQ 3919
Query: 454 ESKSSSEEDGQLKNIEIESRKLTVDAYHN 482
S+++E G ++ +S AYH+
Sbjct: 3920 SDSSTAKEHGHFSSLSQDS------AYHS 3942
Score = 69.7 bits (169), Expect = 6e-12
Identities = 101/463 (21%), Positives = 173/463 (37%), Gaps = 65/463 (14%)
Query: 51 SDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDR 110
S + G+G R +G S + D + ED +GP +
Sbjct: 2013 SADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQGKAGPHQQSH 2072
Query: 111 QEGGNSRLGSDEDSD-------DTIQASE----ESAP-----QGQ--DSAQDTTSESREL 152
+E + G T + SE +SAP QG D AQD++ S
Sbjct: 2073 KESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQGSHYDQAQDSSRHSASQ 2132
Query: 153 DNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERG 212
+ +D + P ++ +E V S H S +G +SD + RG
Sbjct: 2133 EGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHSGSHH---SHTTSQG-RSD------ASRG 2182
Query: 213 NSRMNSAGMKS---KESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDN 269
S SA K+ ++SG+ S + + S + + + + S R+
Sbjct: 2183 QSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSLVGQGQSS--GPRTSRPRG 2240
Query: 270 NTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVD----GPSSESS 325
+++ + SDS +S + R+ G +QE S++ S + D G S+ESS
Sbjct: 2241 SSVSQ-DSDSEGHSEDSERRSGSASRNHHGSAQEQSRDGSRHPRSHHEDRAGHGHSAESS 2299
Query: 326 QEANLSSQENSSESQEEVVSE-SRGDNPDPTTSYVEDQEDSD-----------SSEEDSS 373
+++ ENSS Q E +R + S+ + DS S+ DS
Sbjct: 2300 RQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSG 2359
Query: 374 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENS-----------SSQEGLQSHSS 422
H S S S++ + + SE S++ + S P ++ S + G +
Sbjct: 2360 HRGS-SGSQASDSEGHSEDSDTQSVSAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQV 2418
Query: 423 SAESQSEESHSEEDDS-DSQDSSRSKEDSNSTESKSSSEEDGQ 464
S QSE +H S + S K+ +S S+ S+ ++GQ
Sbjct: 2419 STHEQSESAHGRTGTSTGGRQGSHHKQARDS--SRHSTSQEGQ 2459
Score = 69.3 bits (168), Expect = 8e-12
Identities = 91/479 (18%), Positives = 166/479 (34%), Gaps = 49/479 (10%)
Query: 18 PVTR-YQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGG-- 74
P TR Q + E +++ H A P S +G H++ +G
Sbjct: 2757 PSTRGRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGY---HHEHSVDSSGHSG 2813
Query: 75 --FSRSTGKGGDDKDDDEDDS--------GDDTFGDDDSGPGPKDRQEGGNSRLGSDEDS 124
S +T +G D + S ++ GD G + + ++ + +
Sbjct: 2814 SHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQA 2873
Query: 125 -DDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESE----------S 173
+ S S QG +QD+ SE D+E S + + +
Sbjct: 2874 VQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSH 2933
Query: 174 EEHWVGGGSDGESSHGDGS---ELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENS 230
+E G G +SS G+ + G + E RS G G ++S ++S
Sbjct: 2934 QEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERH----GSHHQQSADSS 2989
Query: 231 EQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDT-- 288
+ S + + + S+ S+ + SE D ++ + + +++
Sbjct: 2990 RHSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESAR 3049
Query: 289 GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ-----EANLSSQENSSESQEEV 343
G S G + E S GPS+ Q +A SS+ ++S+ ++
Sbjct: 3050 GRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQDSSRHSASQYGQDT 3109
Query: 344 VSESRGDNPDPTTSYVEDQEDSDSSEEDS--SHTLSHSKSESREEQADSESSESLNFSEE 401
+ G + Y + S S SHT S +S++ Q+ S S+ +EE
Sbjct: 3110 IRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEE 3169
Query: 402 SPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 460
SS+ + H ++ HS+ S+ S RS+ +S S SE
Sbjct: 3170 Q------SGDSSRHSVSRHHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSE 3222
Score = 68.9 bits (167), Expect = 1e-11
Identities = 97/484 (20%), Positives = 174/484 (35%), Gaps = 52/484 (10%)
Query: 27 SEDSEEWKGHLAQ-------------APTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAG 73
SEDSE W G ++ + P ED + S + ++ +G
Sbjct: 2577 SEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSG 2636
Query: 74 GFSRSTG---------KGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNS------RL 118
G + S+ + G D S G + +D G S
Sbjct: 2637 GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNE 2696
Query: 119 GSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWV 178
G EDSD ++ A Q S Q++ + R + S + ++SES W
Sbjct: 2697 GHSEDSDTQSVSAHGQAGSHQQSHQES-ARGRSGETSGHSGSFLYQVSTHEQSESSHGWT 2755
Query: 179 GGGSDGE--SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQ 236
G + G S H + D ++IR G+SR G + S ++S + +
Sbjct: 2756 GPSTRGRQGSRHEQAQDSSRHSASQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSH 2815
Query: 237 DSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGL-SQPRR 295
S + + + SR + R+E + S E S D SQ +
Sbjct: 2816 HSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQ 2875
Query: 296 DSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPT 355
S+ ++ S + + +G S +S + + +S+ + +QE++ SR
Sbjct: 2876 GQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPR---- 2931
Query: 356 TSYVEDQ----EDSDSSEEDSSH---TLSHSKSESREEQADSESSE--------SLNFSE 400
S+ ED+ +DSS + + T S ++ S EQA S + E S + S
Sbjct: 2932 -SHQEDRAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSR 2990
Query: 401 ESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 460
S +S+ ++ S +++ E HSE+ D+ S + + +S+
Sbjct: 2991 HSGIGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARG 3050
Query: 461 EDGQ 464
G+
Sbjct: 3051 RSGE 3054
Score = 67.0 bits (162), Expect = 4e-11
Identities = 98/481 (20%), Positives = 167/481 (34%), Gaps = 48/481 (9%)
Query: 27 SEDSEEWKGHLAQ-------------APTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAG 73
SEDSE W G ++ + P ED + S + ++ +G
Sbjct: 2901 SEDSERWSGSASRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSADSSRQSGTRHTQTSSG 2960
Query: 74 GFSRSTG---------KGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNS------RL 118
G + S+ + G D S G + +D G S
Sbjct: 2961 GQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDNE 3020
Query: 119 GSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWV 178
G EDSD ++ A Q S Q++ + R + S + ++SES W
Sbjct: 3021 GHSEDSDTQSVSAHGQAGSHQQSHQES-ARGRSGETSGHSGSFLYQVSTHEQSESSHGWT 3079
Query: 179 GGGSDGE--SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGM-------KSKESGEN 229
G + G S H + ++IR G+SR G S SG +
Sbjct: 3080 GPSTRGRQGSRHEQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSH 3139
Query: 230 SEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDT- 288
+Q + + SR R +R E+ S + E + + + +S+
Sbjct: 3140 HSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRHSQAVQ 3199
Query: 289 GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE-- 346
G S+ R S+ S+++ S+ S++ + S +S+ S QE S S
Sbjct: 3200 GQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSRHPRSHHE 3259
Query: 347 ---SRGDNPDPTT-SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES 402
G + D + S E S + SSH + S R +S++S S S
Sbjct: 3260 DRAGHGHSADRSRQSGTRHAETSSGGQAASSHEQARSSPGERHGSRHQQSADS---SRHS 3316
Query: 403 PESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED 462
+S+ ++ SS +++ E HSEE D+ S + +S+ +
Sbjct: 3317 GIPRGQASSAVRDSRHWGSSGSQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRS 3376
Query: 463 G 463
G
Sbjct: 3377 G 3377
Score = 66.6 bits (161), Expect = 5e-11
Identities = 79/400 (19%), Positives = 146/400 (36%), Gaps = 30/400 (7%)
Query: 88 DDEDDSGDDTFGDD----DSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
D DSG D DSG + +S S+E ++ A ++ P Q +
Sbjct: 1690 DSSTDSGTGRRQDSSVVGDSGNRGSSGSQASDSEGHSEESDTQSVSAHGQAGPHQQSHQE 1749
Query: 144 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGE--SSHGDGSELDDEGMQS 201
T +S E R S + ++SES G + G S H +
Sbjct: 1750 STRGQSGE--RSGRSGSFLYQVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQ 1807
Query: 202 DDPESIRSERGNSRMNSAGM-------KSKESGENSEQANTQDSGGSQLLEHPSRKIFRK 254
+ ++IR G+SR G S SG + +Q+ + SR + R+
Sbjct: 1808 EGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGSRSVSRQ 1867
Query: 255 SRISEEDDRSELDDNNTMEEVKSDSTENSNSR-DTGLSQPRRDSKGDSQEDSKENLSQEE 313
+R ++ + E S + + +S+ G S R S+ S+++ SQ
Sbjct: 1868 TRNEKQSGDGSRHSGSRHHEASSRADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGH 1927
Query: 314 SQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSS 373
S++ + S +S+ S+ E S + S G + + + + S S +
Sbjct: 1928 SEDSERWSGSASRNHLGSAWEQSRDG-----SRHPGSHHEDRAGHGHSADSSRQSGTRHT 1982
Query: 374 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS---------SSA 424
+ S ++ S EQA S + E + + +S G S + S +
Sbjct: 1983 ESSSRGQAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGS 2042
Query: 425 ESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 464
++ E HSE+ D+ S + + +S+ + G+
Sbjct: 2043 QASDSEGHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGE 2082
Score = 64.7 bits (156), Expect = 2e-10
Identities = 102/436 (23%), Positives = 169/436 (38%), Gaps = 38/436 (8%)
Query: 27 SEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDK 86
SEDSE W G ++ N S QS +G + R G S + +
Sbjct: 3549 SEDSERWSGSASR-------NHRGSAQEQSRDGSRHPTSHHEDRAGHGHSAESSRQSGTH 3601
Query: 87 DDDEDDSGDDTFGDDDSGPGPKDR-----QEGGNSRLGSDEDSDDTIQASEESAPQGQDS 141
+ G + + +R Q+ +S S A +S +G
Sbjct: 3602 HAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGSSG 3661
Query: 142 AQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQS 201
+Q + SE D++ + S G + +S + G S G S GS L
Sbjct: 3662 SQASDSEGHSEDSDTQ--SVSAHGQAGPHQQSHQESTRGRSAGRSGRS-GSFLYQVSTH- 3717
Query: 202 DDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP-SRKIFRKSRISEE 260
+ ES G S G + +++ ++S + +Q+ G + HP SR+ R+ E+
Sbjct: 3718 EQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQE-GQDTIRGHPGSRRGGRQGSYHEQ 3776
Query: 261 D-DRSELDDNN---TMEEVKSDSTEN-SNSRDTGLSQPRRDSKGDSQ--------EDSKE 307
DRS ++ T + +SD++ S SR + GD E S +
Sbjct: 3777 SVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRETRNEEQSGDGSRHSGSRHHEASTQ 3836
Query: 308 NLSQEESQNVDGPSS---ESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQED 364
S SQ+ G S+ S ++ + SQ++ SE+ E SE R ++ ++
Sbjct: 3837 ADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPED-SERRSESASRNHHGSSREQS 3895
Query: 365 SDSSEED-SSHTLSHSKSESREEQADSESS-ESLNFSEESPESPEDENSSSQEGLQSHSS 422
D S SSH + S +S Q+DS ++ E +FS S +S S+ G SS
Sbjct: 3896 RDGSRHPGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYHSGIQSR-GSPHSSS 3954
Query: 423 SAESQSEESHSEEDDS 438
S QSE + ++ S
Sbjct: 3955 SYHYQSEGTERQKGQS 3970
Score = 63.9 bits (154), Expect = 3e-10
Identities = 105/464 (22%), Positives = 173/464 (37%), Gaps = 42/464 (9%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYR-LAGGFSRSTGK 81
Q + E S GH + ++ SD++ + G S Q +G +R +G
Sbjct: 528 QGSHHEQSVNRSGHSGSHHSHT-TSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGS 586
Query: 82 GGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDED--SDDTIQASEESAPQGQ 139
+ D S G S R +G + SD S+D+ + S ++
Sbjct: 587 RHHEASSQADSSRHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHH 646
Query: 140 DSAQDTT---SESRELDNEDRV-------DSKPEGGDSTQESESEE----HWVGGGSDGE 185
SAQ+ + S +EDR S+ G TQ S S + H S GE
Sbjct: 647 GSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGE 706
Query: 186 SSHGDGSELD--DEGMQSDDPESIRSE--RGNSRMNSAGMKSKESGENSEQANTQD-SGG 240
HG +L D S S R + S+G ++ +S +SE ++TQ SG
Sbjct: 707 R-HGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGH 765
Query: 241 SQLLEHP-SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 299
Q H S + + R E RS +S+S+ TG+ Q +
Sbjct: 766 GQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQ- 824
Query: 300 DSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV 359
++++S+ + SQ+ + G S + S E S + S G + TTS
Sbjct: 825 -ARDNSRHSASQDGQDTIRGHPGSSRRGRQGSHHEQSVDR-----SGHSGSHHSHTTS-- 876
Query: 360 EDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQS 419
Q SD+S S + + + E+ D E S + +S + +G
Sbjct: 877 --QGRSDASRGQSGSRSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSE 934
Query: 420 HSSSAESQ----SEESHSE--EDDSDSQDSSRSKEDSNSTESKS 457
S ++ Q S++S SE +DS+ S S+ S + +S
Sbjct: 935 GSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSAQEQS 978
Score = 63.9 bits (154), Expect = 3e-10
Identities = 103/467 (22%), Positives = 164/467 (35%), Gaps = 50/467 (10%)
Query: 27 SEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDK 86
SEDSE W G ++ N S QS G + R G S + +
Sbjct: 956 SEDSERWSGSASR-------NHRGSAQEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTP 1008
Query: 87 DDDEDDSGDDTFGDDDSGPGPKDR-----QEGGNSRLGSDEDSDDTIQASEESAPQGQDS 141
+ G + + P +R Q+ +S S A +S G
Sbjct: 1009 HAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRRQASSAVRDSGHWGSSG 1068
Query: 142 AQDTTSE--SRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGM 199
+Q + SE S E D + +G ES W GG S G S GS +
Sbjct: 1069 SQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARDWSGGRS-GRS----GSFI----Y 1119
Query: 200 QSDDPESIRSERGNSRMNSAGMKSK--ESGENSEQANTQDSGGSQLLEHP-SRKIFRKSR 256
Q E S G +R ++ + E +S + + G + HP SR+ R+
Sbjct: 1120 QVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRAHPGSRRGGRQGS 1179
Query: 257 ISEED-DRSELDDNN---TMEEVKSDSTENSNSRDTGLSQPRRDSK-GDSQEDS----KE 307
E+ DRS ++ T + +SD++ + + Q R+D + GD S E
Sbjct: 1180 HHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRKDKQSGDGSRHSGSRHHE 1239
Query: 308 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS-- 365
S +S E S + S + SS SQ+ D+ + S + S
Sbjct: 1240 AASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSR 1299
Query: 366 DSSEEDSSH---------TLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEG 416
+ S + S H + HS SR Q+ + +ES + + + +S +
Sbjct: 1300 EQSRDGSRHPGFHQEDRASHGHSADSSR--QSGTHHTESSSHGQAVSSHEQARSSPGERH 1357
Query: 417 LQSHSSSAES--QSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE 461
H SA+S S H + + R S T S+ SE+
Sbjct: 1358 GSRHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSED 1404
Score = 63.9 bits (154), Expect = 3e-10
Identities = 85/360 (23%), Positives = 126/360 (35%), Gaps = 41/360 (11%)
Query: 109 DRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDST 168
D Q G SR + + +A Q + SR + DS DS
Sbjct: 2520 DEQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDS-----DSQ 2574
Query: 169 QESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGE 228
SE E W G S + HG E +G S P S + +R S +S
Sbjct: 2575 GHSEDSERWSGSAS--RNHHGSAQEQLRDG--SRHPRSHQEDRAGHG------HSADSSR 2624
Query: 229 NSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKS-DSTENSNSRD 287
S +TQ S G Q S E RS + + +S DS+ +S
Sbjct: 2625 QSGTRHTQTSSGGQAAS------------SHEQARSSAGERHGSHHQQSADSSRHSGIGH 2672
Query: 288 TGLSQPRRDS--KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS 345
S RDS +G S + +N E + S+ ++ S + S+ + S
Sbjct: 2673 GQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGETS 2732
Query: 346 ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPES 405
G V E S+SS + + + + SR EQA S S S++ ++
Sbjct: 2733 GHSGS----FLYQVSTHEQSESSHGWTGPS-TRGRQGSRHEQAQDSSRHSA--SQDGQDT 2785
Query: 406 PEDENSSSQEGLQS----HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE 461
SS+ G Q HS + S HS D+SR + S S + +EE
Sbjct: 2786 IRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEE 2845
Score = 61.6 bits (148), Expect = 2e-09
Identities = 84/434 (19%), Positives = 140/434 (32%), Gaps = 60/434 (13%)
Query: 78 STGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLG--SDEDSDDTIQASEESA 135
S + D + E+ G +G + QE R G S Q S
Sbjct: 418 SGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQ 477
Query: 136 PQG----------------QDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVG 179
P + A+D++ S + +D + P ++ E V
Sbjct: 478 PDSAHGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVN 537
Query: 180 GGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 239
S H + S + R +G ++ SG +A++Q
Sbjct: 538 RSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADS 597
Query: 240 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGL--SQPRRDS 297
R S++ + N V DS +S D+ R+
Sbjct: 598 S------------RHSQVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNH 645
Query: 298 KGDSQEDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQ----EEVVSESRG 349
G +QE S++ S + D G S++SS+++ +NSS Q E S G
Sbjct: 646 HGSAQEQSRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAG 705
Query: 350 D---------NPDPTTSYVEDQEDSDSSEEDSSH--------TLSHSKSESREEQADSES 392
+ + D + + S+ DS H T S SE + Q+ S
Sbjct: 706 ERHGSRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGH 765
Query: 393 SESLNFSEESPESPEDENS--SSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDS 450
++ + + ES D + S + G + S QSE SH S E +
Sbjct: 766 GQAGHHQQSHQESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQA 825
Query: 451 NSTESKSSSEEDGQ 464
S+ S+ +DGQ
Sbjct: 826 RD-NSRHSASQDGQ 838
Score = 60.1 bits (144), Expect = 5e-09
Identities = 85/421 (20%), Positives = 149/421 (35%), Gaps = 27/421 (6%)
Query: 47 NEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPG 106
++ +DS++ G+G R +G S + D + ED +GP
Sbjct: 2334 HQQSADSSR-HSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPH 2392
Query: 107 PKDRQEG--GNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG 164
+ QE G S S Q S + T++ R+ + +
Sbjct: 2393 QQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRTGTSTGGRQGSHHKQARDSSRH 2452
Query: 165 GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK 224
S QE + H G S G +L D S S + +G S S G
Sbjct: 2453 STS-QEGQDTIHGHPGSSSGGRQGSHYEQLVDRSGHSGSHHSHTTSQGRSDA-SHGHSGS 2510
Query: 225 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 284
S + + Q GS+ SR E R++ ++ + + +S+ S
Sbjct: 2511 RSASRQTRNDEQSGDGSR---------HSGSRHHEASSRADSSGHSQVGQGQSEGPRTSR 2561
Query: 285 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV 344
+ + SQ DS+G S++ E S S+N G S+QE + QE+
Sbjct: 2562 NWGSSFSQDS-DSQGHSEDS--ERWSGSASRNHHG----SAQEQLRDGSRHPRSHQED-- 2612
Query: 345 SESRGDNPDPTT-SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESP 403
G + D + S + S + SSH + S + R +S++S S S
Sbjct: 2613 RAGHGHSADSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADS---SRHSG 2669
Query: 404 ESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDG 463
+S+ ++ S +++ E HSE+ D+ S + + +S+ G
Sbjct: 2670 IGHGQASSAVRDSGHRGYSGSQASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSG 2729
Query: 464 Q 464
+
Sbjct: 2730 E 2730
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/424 (20%), Positives = 154/424 (36%), Gaps = 66/424 (15%)
Query: 68 IYRLAGGFSRSTGKGG----------DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSR 117
+++LA + ST K D +D+ + ++ P +R+
Sbjct: 78 VFKLAQAYYESTRKENLPISGHKHRKHSHHDKHEDNKQEENKENRKRPSSLERRNNRKGN 137
Query: 118 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 177
G + +T ES+ SE +E + E G + S +E
Sbjct: 138 KGRSKSPRETGGKRHESS-----------SEKKERKGYSPTHREEEYGKNHHNSSKKEK- 185
Query: 178 VGGGSDGESSHGDGSELDDEGMQS--DDPESIRSERGNSRMNSAGMKSKESGE----NSE 231
+ GD + E ++ D+ E + RM ++S E
Sbjct: 186 ---NKTENTRLGDNRKRLSERLEEKEDNEEGVYDYENTGRMTQKWIQSGHIATYYTIQDE 242
Query: 232 QANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNN--TMEEVKSDSTENSNSRDTG 289
+T DS LLE KI+ +SR S+ S+++ + +V + R +
Sbjct: 243 AYDTTDS----LLEE--NKIYERSRSSDGKSSSQVNRSRHENTSQVPLQESRTRKRRGSR 296
Query: 290 LSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRG 349
+SQ R DS+G S++ + S S+N G + E S++ + + + + S G
Sbjct: 297 VSQDR-DSEGHSEDSERH--SGSASRNHHGSAWEQSRDGSRHPRSHDEDRA------SHG 347
Query: 350 DNPDPTT-SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPED 408
+ D + S E S + SSH + S R +S++S S S
Sbjct: 348 HSADSSRQSGTRHAETSSRGQTASSHEQARSSPGERHGSGHQQSADS---SRHSATGRGQ 404
Query: 409 ENSSSQEGLQSHSSSAESQSEESHSEEDDSDS--------------QDSSRSKEDSNSTE 454
+S+ + SS +++ E HSE D+ S Q+S+R + S
Sbjct: 405 ASSAVSDRGHRGSSGSQASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGR 464
Query: 455 SKSS 458
S SS
Sbjct: 465 SGSS 468
Score = 50.1 bits (118), Expect = 5e-06
Identities = 64/268 (23%), Positives = 103/268 (38%), Gaps = 33/268 (12%)
Query: 209 SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSE--L 266
SE+ + S + +E G+N ++ ++ ++ + R+ E++D E
Sbjct: 156 SEKKERKGYSPTHREEEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDNEEGVY 215
Query: 267 DDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ 326
D NT + + + D+ E EN E S++ DG +SS
Sbjct: 216 DYENTGRMTQKWIQSGHIATYYTIQDEAYDTTDSLLE---ENKIYERSRSSDG---KSSS 269
Query: 327 EANLSSQENSSES--QEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESR 384
+ N S EN+S+ QE + RG S V DS+ EDS HS S SR
Sbjct: 270 QVNRSRHENTSQVPLQESRTRKRRG-------SRVSQDRDSEGHSEDSER---HSGSASR 319
Query: 385 E------EQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH------ 432
EQ+ S + E+ +SS Q G + +S+ Q+ SH
Sbjct: 320 NHHGSAWEQSRDGSRHPRSHDEDRASHGHSADSSRQSGTRHAETSSRGQTASSHEQARSS 379
Query: 433 -SEEDDSDSQDSSRSKEDSNSTESKSSS 459
E S Q S+ S S + ++SS
Sbjct: 380 PGERHGSGHQQSADSSRHSATGRGQASS 407
Score = 43.9 bits (102), Expect = 3e-04
Identities = 70/343 (20%), Positives = 137/343 (39%), Gaps = 39/343 (11%)
Query: 139 QDSAQDTTSESRELDN--EDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDD 196
+D+ Q+ E+R+ + E R + K G S E+ S+ + G +
Sbjct: 111 EDNKQEENKENRKRPSSLERRNNRKGNKGRSKSPRETGGKRHESSSEKKERKGYSPTHRE 170
Query: 197 EGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG--GSQLLEHPSRKIFRK 254
E + S + E+ + G K E E+ + G + ++K +
Sbjct: 171 EEYGKNHHNSSKKEKNKTENTRLGDNRKRLSERLEEKEDNEEGVYDYENTGRMTQKWIQS 230
Query: 255 SRISE---------EDDRSELDDNNTMEEVKSDSTENSN----SRDTGLSQ-PRRDSKGD 300
I+ + S L++N E +S ++S+ SR SQ P ++S+
Sbjct: 231 GHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSSQVNRSRHENTSQVPLQESRTR 290
Query: 301 SQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 360
+ S+ + + ++ +G S +S + + +S+ + + E+ SR + P S+ E
Sbjct: 291 KRRGSRVS----QDRDSEGHSEDSERHSGSASRNHHGSAWEQ----SRDGSRHPR-SHDE 341
Query: 361 DQEDSDSSEEDSSHT-LSHSKSESREEQADSESSESLNFSEESPESP-EDENSSSQEGLQ 418
D+ S + S + H+++ SR + A S E++ SP E S Q+
Sbjct: 342 DRASHGHSADSSRQSGTRHAETSSRGQTASSH--------EQARSSPGERHGSGHQQSAD 393
Query: 419 S--HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSS 459
S HS++ Q+ + S+ S S S + +S S + S
Sbjct: 394 SSRHSATGRGQASSAVSDRGHRGSSGSQASDSEGHSENSDTQS 436
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 79.3 bits (194), Expect = 7e-15
Identities = 102/515 (19%), Positives = 204/515 (39%), Gaps = 66/515 (12%)
Query: 22 YQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGK 81
+ +N+SE+ E+ + P + SD DD + + A G ++ + K
Sbjct: 108 FDDNDSEELEDKDSKSKKTAKPKVEMYSGSDD--------DDDFNKLPKKAKGKAQKSNK 159
Query: 82 GGDDKDDDED---------------DSGDDTFGDDDSGPGPKDRQE---GGNSRLGSDED 123
D ++DED +SGD++ S G K Q+ G N G+++D
Sbjct: 160 KWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDD 219
Query: 124 SDD-----TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESES--EEH 176
Q E + + + ++ R+L ++ +++ + +ES+ EE
Sbjct: 220 DASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE 279
Query: 177 WVGGGSDGESSHGDGSELDDEGMQS--DDPESIRSERGNSRMNSAGMKSKESGENSEQAN 234
V ++ SE E + DD E + ++ K K+ GE E+
Sbjct: 280 TVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD---------KKKKKGEKEEKEK 330
Query: 235 TQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPR 294
+ G S+ ++ K + EE++R + ++ ++ + + E + L Q +
Sbjct: 331 EKKKGPSKATVKAMQEALAK--LKEEEERQKREEEERIKRL--EELEAKRKEEERLEQEK 386
Query: 295 RDSKGDSQEDSKENLSQE-----ESQNVDGPSSESS----QEANLSSQENSSESQEEVVS 345
R+ K +++ KE L +E +SQ +E++ Q + S ++ +
Sbjct: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIY 446
Query: 346 ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEES--- 402
E + P +E +E S+S E ++ + +EE E +E++
Sbjct: 447 EDKKRKKIP--QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504
Query: 403 --PESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 460
DE + EG + H E+ EE EE++ + ++S +E+ +E E
Sbjct: 505 DWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDE 564
Query: 461 EDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 495
ED ++ + E +S K T+D +K + + D D
Sbjct: 565 EDEKVSD-EKDSGK-TLDKKPSKEMSSDSEYDSDD 597
Score = 53.9 bits (128), Expect = 3e-07
Identities = 56/309 (18%), Positives = 123/309 (39%), Gaps = 28/309 (9%)
Query: 212 GNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNT 271
G + N + +K+ + A + G+ + P + +K + ++ D E D
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKE 61
Query: 272 MEEVKSDSTENSNSRDTGLSQP---------RRDSKGDSQEDSKENLSQEESQNVDGPSS 322
+EE+ ++ R+T +P +D K Q+ K++ +S+ ++ S
Sbjct: 62 LEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDS 121
Query: 323 ESSQEA----NLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSH 378
+S + A + S + + ++ +++G + +ED D+S++ + +
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
Query: 379 SKSESREEQAD------SESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH 432
S ES +E + + N + ES +++ +S + AE + E
Sbjct: 182 SSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERK 241
Query: 433 SEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLK-NIEIESRKLTVD-----AYHNK--- 483
+++ + KE+ + + S +++ Q K E K+TVD A K
Sbjct: 242 KRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAET 301
Query: 484 PIGDQDDND 492
P +DDN+
Sbjct: 302 PTAAEDDNE 310
Score = 44.7 bits (104), Expect = 2e-04
Identities = 81/425 (19%), Positives = 146/425 (34%), Gaps = 63/425 (14%)
Query: 21 RYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTG 80
R + N S +S + Q+ N+ E G DD + +
Sbjct: 177 RSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKK 236
Query: 81 KGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDS--------DDTIQASE 132
+ K D+E ++ G KD+ + S+ +E++ I ASE
Sbjct: 237 ERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASE 296
Query: 133 ESAPQGQDSAQDTTSESRELDN-------EDRVDSKPEGGDSTQESESEEHWVGGGSDGE 185
E A + D + ++ D E++ K +G +E + E
Sbjct: 297 EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356
Query: 186 SSHGDGSE-------LDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGE----NSEQAN 234
+ E L+ + + + E + ER + + K+ G+ + +A
Sbjct: 357 RQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREAR 416
Query: 235 TQDSGGSQLL-----EHPSRKIFRKSR-ISEEDDRSELDDNNTMEEVKSDST-------- 280
+ +LL E PS+ K R I E+ R ++ +EV
Sbjct: 417 ARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVM 476
Query: 281 -----ENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPS---------SESSQ 326
E + + D++ +D + S EE++ V+G E +
Sbjct: 477 EQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEE 536
Query: 327 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 386
E ++ SE +EE ES G D ++++ S E+DS TL K S+E
Sbjct: 537 EEEEEEEDEESEEEEEEEGESEGSEGD-------EEDEKVSDEKDSGKTL--DKKPSKEM 587
Query: 387 QADSE 391
+DSE
Sbjct: 588 SSDSE 592
>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 76.3 bits (186), Expect = 6e-14
Identities = 81/394 (20%), Positives = 155/394 (39%), Gaps = 52/394 (13%)
Query: 126 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGS 182
D++ ASE + P + S S+ E +P +++E + G S
Sbjct: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGAS 445
Query: 183 DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 242
+ + + +EG + E +RG S K E G N + + +DS
Sbjct: 446 ENNAKESSPEKEAEEGCPEKESEEGCPKRGFE--GSCSQKESEEG-NPVRGSEEDS---- 498
Query: 243 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 302
P ++ +K+ +++ ++N +E + D + S + + + DS+
Sbjct: 499 ----PKKESKKKTL------KNDCEENGLAKESEDDLNKESEEE---VGPTKESEEDDSE 545
Query: 303 EDSKENLSQEESQN-VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVED 361
++S E+ S+++S++ + E+ E +L + + E E V+ + +N + + +D
Sbjct: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
Query: 362 QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS 421
+ EE S E EE+ E F +ES E EDE + ++GL++
Sbjct: 606 GSEKVLDEEGSEREFDEDSDEKEEEEDTYEKV----FDDESDEK-EDEEYADEKGLEAAD 660
Query: 422 SSAE--SQSEESHSEEDDSDSQDSSRSK---------EDSNSTESKSSSEEDGQLKNIEI 470
AE E+ E DD + +D+ + ED +S E EED K +
Sbjct: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
Query: 471 ESRKLTVDAYHNKPIG------------DQDDND 492
+ T+ + + G D DD+D
Sbjct: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 66.2 bits (160), Expect = 6e-11
Identities = 79/393 (20%), Positives = 149/393 (37%), Gaps = 46/393 (11%)
Query: 120 SDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVG 179
+D ++T + EE +G ++ + +R L D V + G S SE
Sbjct: 351 TDYQVEETSREREERL-RGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS 409
Query: 180 GGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 239
+ E++ G E E I ++ + + S N+++++ +
Sbjct: 410 KMNAQETATGMAFE-----------EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
Query: 240 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 299
E S + K + E ++ N + + DS + + + T + +
Sbjct: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
Query: 300 DSQEDSKENLSQEESQNVDGPSSESSQE-ANLSSQENSSESQEEVVSESRGDNPDPTTSY 358
ED S+EE GP+ ES ++ + S E+ SE Q E SE +
Sbjct: 519 KESEDDLNKESEEEV----GPTKESEEDDSEKESDEDCSEKQSEDGSERE---------F 565
Query: 359 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 418
E+ + D EE S L + + E+ DSE+SE F ++ E DE S +E +
Sbjct: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSE---FEDDGSEKVLDEEGSEREFDE 622
Query: 419 SHSSSAESQSEESHSEEDDSDSQD------------SSRSKEDSNS-----TESKSSSEE 461
E + +D+SD ++ + + E+ ++ ES +E
Sbjct: 623 DSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE 682
Query: 462 DGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQ 494
D K +E KL D N+ + D++++ +
Sbjct: 683 DADGKEVEDADEKLFEDDDSNEKLFDEEEDSSE 715
Score = 62.0 bits (149), Expect = 1e-09
Identities = 77/355 (21%), Positives = 143/355 (40%), Gaps = 64/355 (18%)
Query: 12 GLSCALPVTRYQNNESEDSEEWKG----HLAQAPTPPLANEDPSDSTQSEEGLGSDDHQY 67
G++ P+ + ++ED E++ + A+ +P E+ +SEEG
Sbjct: 419 GMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKR---- 474
Query: 68 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDT 127
GF S + E + G+ G ++ P ++E L +D + +
Sbjct: 475 ------GFEGSCSQ-------KESEEGNPVRGSEEDSP----KKESKKKTLKNDCEENGL 517
Query: 128 IQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS 187
+ SE+ + + T ES E D+ E ES+E S+ +S
Sbjct: 518 AKESEDDLNKESEEEVGPTKESEEDDS---------------EKESDEDC----SEKQSE 558
Query: 188 HGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN-SEQANTQDSGGSQLLEH 246
G E ++ G++ D E G+ + + KE EN SE + +D G ++L+
Sbjct: 559 DGSEREFEENGLEKD-----LDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDE 613
Query: 247 PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR----DTGL-SQPRRDSKGDS 301
R +ED + ++ +T E+V D ++ + GL + ++ +GD+
Sbjct: 614 EG-----SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDA 668
Query: 302 QEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE---SQEEVVSESRGDNPD 353
E E +E ++ DG E + E L ++S+E +EE SE D+ D
Sbjct: 669 DEKLFEESDDKEDEDADGKEVEDADE-KLFEDDDSNEKLFDEEEDSSEKLFDDSD 722
Score = 53.5 bits (127), Expect = 4e-07
Identities = 63/353 (17%), Positives = 130/353 (36%), Gaps = 24/353 (6%)
Query: 159 DSKPEGGDSTQESESEE----------HWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 208
D P+G S + EE W GG + ++ E + E +R
Sbjct: 308 DRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLR 367
Query: 209 SERG--NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSEL 266
N+ + G++ +S SE+A S EHPS S+++ ++ + +
Sbjct: 368 GWEAFLNAPEANRGLRRSDSVSASERAGP--SRARHFSEHPST-----SKMNAQETATGM 420
Query: 267 DDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ 326
++E K + TE+ + G S+ + +++++E ++ES+
Sbjct: 421 AFEEPIDEKKFEKTEDGGEFEEGASE-NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGS 479
Query: 327 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 386
+ S+E + E S + + E+ + SE+D + ++E
Sbjct: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES 539
Query: 387 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHS----EEDDSDSQD 442
+ D ES E E + GL+ S+ E + E +++DS++
Sbjct: 540 EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN 599
Query: 443 SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 495
S + S + SE + + E E + T + + +++D + D
Sbjct: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
Score = 33.9 bits (76), Expect = 0.35
Identities = 36/139 (25%), Positives = 58/139 (41%), Gaps = 19/139 (13%)
Query: 28 EDSEEWKGHLAQAPTPPLANEDPSDSTQSEE-----GLGSDDHQYIYRLAGGFSRSTGKG 82
EDS+E + + T +D SD + EE GL + D + G +
Sbjct: 622 EDSDEKE---EEEDTYEKVFDDESDEKEDEEYADEKGLEAADKK---AEEGDADEKLFEE 675
Query: 83 GDDKDDDE------DDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ--ASEES 134
DDK+D++ +D+ + F DDDS D +E + +L D D T+ S E
Sbjct: 676 SDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEE 735
Query: 135 APQGQDSAQDTTSESRELD 153
P S+ +S+ + D
Sbjct: 736 GPLSTGSSFILSSDDDDDD 754
>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
Length = 755
Score = 76.3 bits (186), Expect = 6e-14
Identities = 81/394 (20%), Positives = 155/394 (39%), Gaps = 52/394 (13%)
Query: 126 DTIQASEESAPQGQDSAQDTTSESRELDNEDRVD---SKPEGGDSTQESESEEHWVGGGS 182
D++ ASE + P + S S+ E +P +++E + G S
Sbjct: 386 DSVSASERAGPSRARHFSEHPSTSKMNAQETATGMAFEEPIDEKKFEKTEDGGEFEEGAS 445
Query: 183 DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQ 242
+ + + +EG + E +RG S K E G N + + +DS
Sbjct: 446 ENNAKESSPEKEAEEGCPEKESEEGCPKRGFE--GSCSQKESEEG-NPVRGSEEDS---- 498
Query: 243 LLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQ 302
P ++ +K+ +++ ++N +E + D + S + + + DS+
Sbjct: 499 ----PKKESKKKTL------KNDCEENGLAKESEDDLNKESEEE---VGPTKESEEDDSE 545
Query: 303 EDSKENLSQEESQN-VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVED 361
++S E+ S+++S++ + E+ E +L + + E E V+ + +N + + +D
Sbjct: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDD 605
Query: 362 QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHS 421
+ EE S E EE+ E F +ES E EDE + ++GL++
Sbjct: 606 GSEKVLDEEGSEREFDEDSDEKEEEEDTYEKV----FDDESDEK-EDEEYADEKGLEAAD 660
Query: 422 SSAE--SQSEESHSEEDDSDSQDSSRSK---------EDSNSTESKSSSEEDGQLKNIEI 470
AE E+ E DD + +D+ + ED +S E EED K +
Sbjct: 661 KKAEEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDD 720
Query: 471 ESRKLTVDAYHNKPIG------------DQDDND 492
+ T+ + + G D DD+D
Sbjct: 721 SDERGTLGGFGSVEEGPLSTGSSFILSSDDDDDD 754
Score = 66.2 bits (160), Expect = 6e-11
Identities = 79/393 (20%), Positives = 149/393 (37%), Gaps = 46/393 (11%)
Query: 120 SDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVG 179
+D ++T + EE +G ++ + +R L D V + G S SE
Sbjct: 351 TDYQVEETSREREERL-RGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTS 409
Query: 180 GGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 239
+ E++ G E E I ++ + + S N+++++ +
Sbjct: 410 KMNAQETATGMAFE-----------EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEA 458
Query: 240 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKG 299
E S + K + E ++ N + + DS + + + T + +
Sbjct: 459 EEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLA 518
Query: 300 DSQEDSKENLSQEESQNVDGPSSESSQE-ANLSSQENSSESQEEVVSESRGDNPDPTTSY 358
ED S+EE GP+ ES ++ + S E+ SE Q E SE +
Sbjct: 519 KESEDDLNKESEEEV----GPTKESEEDDSEKESDEDCSEKQSEDGSERE---------F 565
Query: 359 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 418
E+ + D EE S L + + E+ DSE+SE F ++ E DE S +E +
Sbjct: 566 EENGLEKDLDEEGSEKELHENVLDKELEENDSENSE---FEDDGSEKVLDEEGSEREFDE 622
Query: 419 SHSSSAESQSEESHSEEDDSDSQD------------SSRSKEDSNS-----TESKSSSEE 461
E + +D+SD ++ + + E+ ++ ES +E
Sbjct: 623 DSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKEDE 682
Query: 462 DGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQ 494
D K +E KL D N+ + D++++ +
Sbjct: 683 DADGKEVEDADEKLFEDDDSNEKLFDEEEDSSE 715
Score = 62.0 bits (149), Expect = 1e-09
Identities = 77/355 (21%), Positives = 143/355 (40%), Gaps = 64/355 (18%)
Query: 12 GLSCALPVTRYQNNESEDSEEWKG----HLAQAPTPPLANEDPSDSTQSEEGLGSDDHQY 67
G++ P+ + ++ED E++ + A+ +P E+ +SEEG
Sbjct: 419 GMAFEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKR---- 474
Query: 68 IYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDT 127
GF S + E + G+ G ++ P ++E L +D + +
Sbjct: 475 ------GFEGSCSQ-------KESEEGNPVRGSEEDSP----KKESKKKTLKNDCEENGL 517
Query: 128 IQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESS 187
+ SE+ + + T ES E D+ E ES+E S+ +S
Sbjct: 518 AKESEDDLNKESEEEVGPTKESEEDDS---------------EKESDEDC----SEKQSE 558
Query: 188 HGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN-SEQANTQDSGGSQLLEH 246
G E ++ G++ D E G+ + + KE EN SE + +D G ++L+
Sbjct: 559 DGSEREFEENGLEKD-----LDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLDE 613
Query: 247 PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSR----DTGL-SQPRRDSKGDS 301
R +ED + ++ +T E+V D ++ + GL + ++ +GD+
Sbjct: 614 EG-----SEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDA 668
Query: 302 QEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE---SQEEVVSESRGDNPD 353
E E +E ++ DG E + E L ++S+E +EE SE D+ D
Sbjct: 669 DEKLFEESDDKEDEDADGKEVEDADE-KLFEDDDSNEKLFDEEEDSSEKLFDDSD 722
Score = 53.5 bits (127), Expect = 4e-07
Identities = 63/353 (17%), Positives = 130/353 (36%), Gaps = 24/353 (6%)
Query: 159 DSKPEGGDSTQESESEE----------HWVGGGSDGESSHGDGSELDDEGMQSDDPESIR 208
D P+G S + EE W GG + ++ E + E +R
Sbjct: 308 DRHPDGVASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLR 367
Query: 209 SERG--NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSEL 266
N+ + G++ +S SE+A S EHPS S+++ ++ + +
Sbjct: 368 GWEAFLNAPEANRGLRRSDSVSASERAGP--SRARHFSEHPST-----SKMNAQETATGM 420
Query: 267 DDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ 326
++E K + TE+ + G S+ + +++++E ++ES+
Sbjct: 421 AFEEPIDEKKFEKTEDGGEFEEGASE-NNAKESSPEKEAEEGCPEKESEEGCPKRGFEGS 479
Query: 327 EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREE 386
+ S+E + E S + + E+ + SE+D + ++E
Sbjct: 480 CSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKES 539
Query: 387 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHS----EEDDSDSQD 442
+ D ES E E + GL+ S+ E + E +++DS++
Sbjct: 540 EEDDSEKESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN 599
Query: 443 SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDNDCQD 495
S + S + SE + + E E + T + + +++D + D
Sbjct: 600 SEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYAD 652
Score = 33.9 bits (76), Expect = 0.35
Identities = 36/139 (25%), Positives = 58/139 (41%), Gaps = 19/139 (13%)
Query: 28 EDSEEWKGHLAQAPTPPLANEDPSDSTQSEE-----GLGSDDHQYIYRLAGGFSRSTGKG 82
EDS+E + + T +D SD + EE GL + D + G +
Sbjct: 622 EDSDEKE---EEEDTYEKVFDDESDEKEDEEYADEKGLEAADKK---AEEGDADEKLFEE 675
Query: 83 GDDKDDDE------DDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQ--ASEES 134
DDK+D++ +D+ + F DDDS D +E + +L D D T+ S E
Sbjct: 676 SDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGSVEE 735
Query: 135 APQGQDSAQDTTSESRELD 153
P S+ +S+ + D
Sbjct: 736 GPLSTGSSFILSSDDDDDD 754
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 75.5 bits (184), Expect = 1e-13
Identities = 80/383 (20%), Positives = 149/383 (38%), Gaps = 41/383 (10%)
Query: 118 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 177
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 178 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 237
+ + S + ++D G + DD +I+ + SR + E + + ++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHS 115
Query: 238 SGGSQLLEHPSRKIFRKSRISEEDDRSELD-DNNTMEEVKSDSTENSNSRDTGLSQPRRD 296
+ G + R+ R+ R EE D++ + + E+ + + R L + R
Sbjct: 116 AEGGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 175
Query: 297 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR------- 348
+ ++ ++ +E + + E +S+ + E + V S
Sbjct: 176 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 349 --------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADS 390
GD P S ++D DS+ + + + S S S EE+ +
Sbjct: 236 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 295
Query: 391 ESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS------ 444
E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 296 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 355
Query: 445 ---RSKEDSNSTESKSSSEEDGQ 464
S+ D +S ES+ + EE G+
Sbjct: 356 VVPESRFDRDSGESEEAEEEVGE 378
Score = 62.0 bits (149), Expect = 1e-09
Identities = 81/386 (20%), Positives = 141/386 (36%), Gaps = 44/386 (11%)
Query: 83 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 142
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 143 QDTTSESRELDNEDRVDSKPEGGDST--------------------QESESEEHWVGGGS 182
+ T + ED ++ + E DS + E H
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAE 117
Query: 183 DGESSHGDGSELDDEGMQSDDPESIRSE-RGNSRMNSAGMKSKESGENSEQANTQDSGGS 241
G+ + E + ++ + R E R A S+ + EQ +
Sbjct: 118 GGKHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERER 177
Query: 242 QLLEHPSRKIFRKSRISEEDDRSELDD--------NNTMEEVKSDSTENSNSRDTGLSQP 293
++ E + +K R ++R + + + TM E SD + S+ + P
Sbjct: 178 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237
Query: 294 R-RDSKGDSQEDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESR 348
R R GD ++ KE +E D S + A SS E+ S S+EE E
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 297
Query: 349 GDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEES 402
+ T+ E++E+ + EE+ + + S SE S EE ++ E E+ N
Sbjct: 298 EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVV 357
Query: 403 PESPEDENSSSQEGLQSHSSSAESQS 428
PES D +S E + QS
Sbjct: 358 PESRFDRDSGESEEAEEEVGEGTPQS 383
Score = 40.4 bits (93), Expect = 0.004
Identities = 36/157 (22%), Positives = 61/157 (38%), Gaps = 28/157 (17%)
Query: 107 PKDRQEGGNSR-------------LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELD 153
P++R E G+ R L +D D+ + + + +S + E E +
Sbjct: 237 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 296
Query: 154 NEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD---------- 203
E+ S E + +E E EE G + E+S E+ +E M D+
Sbjct: 297 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 356
Query: 204 -PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG 239
PES R +R + A +E GE + Q++ G
Sbjct: 357 VPES-RFDRDSGESEEA---EEEVGEGTPQSSALTEG 389
Score = 38.5 bits (88), Expect = 0.014
Identities = 26/117 (22%), Positives = 54/117 (46%), Gaps = 10/117 (8%)
Query: 90 EDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTT--- 146
E S + G ++ ++ +E G++ S+E+ ++ + EE+ +++++ +
Sbjct: 278 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 337
Query: 147 -----SESRELDNEDRVDSKPEG--GDSTQESESEEHWVGGGSDGESSHGDGSELDD 196
SE E +NE+ + PE + ESE E VG G+ S+ +G + D
Sbjct: 338 SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPD 394
>gi|16445033 ACRC protein [Homo sapiens]
Length = 691
Score = 74.3 bits (181), Expect = 2e-13
Identities = 54/252 (21%), Positives = 113/252 (44%), Gaps = 27/252 (10%)
Query: 228 ENSEQANTQDSGGSQLLE-----------HPSRKIFRKSRISEEDDRSELDDNNTMEEVK 276
++ E+ +T + ++LLE H I + +DD DDN EV
Sbjct: 82 DSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDND--DDNGNDLEVP 139
Query: 277 SDSTENSNSRDTGLSQPRRDSKGDSQ--EDSKENLSQEESQNVDGPSSESSQEANLSSQE 334
D++++S + D D+ DS+ +D+ ++ + + D + + + + + +
Sbjct: 140 DDNSDDSEAPD--------DNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDD 191
Query: 335 NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE--DSSHTLSHSKSESREEQADSES 392
NS +S ++ +S DN D + + +DSD ++ D S S +S S+
Sbjct: 192 NSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDD 251
Query: 393 SESLNFSEESPESPED--ENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDS 450
SE+ + S + E+P+D ++S + + S +++ S++S + +D SD ++ K D
Sbjct: 252 SEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSDDSEAPDDKSDD 311
Query: 451 NSTESKSSSEED 462
+ S + D
Sbjct: 312 SDVPEDKSDDSD 323
Score = 70.5 bits (171), Expect = 3e-12
Identities = 60/262 (22%), Positives = 113/262 (43%), Gaps = 28/262 (10%)
Query: 203 DPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDD 262
+P + S+ N N ++ + + +A +S S+ + S DD
Sbjct: 118 EPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNS------------DD 165
Query: 263 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 322
DDN+ E D++++S+ D D+ DS +D+ ++ S + S + D P
Sbjct: 166 SEAPDDNSDDSEAPDDNSDDSDVPD--------DNSDDSSDDNSDDSSDDNSDDSDVPDD 217
Query: 323 ESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE 382
+S S + S +V +S D+ P S + + DSS++ + S SE
Sbjct: 218 KSDD----SDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSE 273
Query: 383 SREEQADSE--SSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDS 440
+ ++ +D S +S + SE S +S +D S + + S E +S++S +D+SD
Sbjct: 274 APDDSSDDSEASDDSSDDSEASDDSSDD--SEAPDDKSDDSDVPEDKSDDSDVPDDNSDD 331
Query: 441 QDSSRSKEDSNSTESKSSSEED 462
+ ED + +S EE+
Sbjct: 332 LEVPVPAEDLCNEGQIASDEEE 353
Score = 68.2 bits (165), Expect = 2e-11
Identities = 74/332 (22%), Positives = 134/332 (40%), Gaps = 42/332 (12%)
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQ 143
DD +DD D+G+D DD+ + + + D++SDD+ +A ++++ + A
Sbjct: 125 DDDNDD--DNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDS-EAPDDNSDDSE--AP 179
Query: 144 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 203
D S+ ++ +++ DS + D + + S++ SD D S++ D+ SDD
Sbjct: 180 DDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDD------SDVPDDKSDDSDVPDD--SSDD 231
Query: 204 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 263
+ +S E+ ++S + S E P DD
Sbjct: 232 SDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPD---------DSSDDS 282
Query: 264 SELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSE 323
DD++ E DS+++S + D D D +DS + V P+ +
Sbjct: 283 EASDDSSDDSEASDDSSDDSEAPDD--KSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAED 340
Query: 324 SSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSES 383
E ++S E E E + S+ D+ D D+ E+D LS S
Sbjct: 341 LCNEGQIASDE--EELVEAAAAVSQHDSSD------------DAGEQDLGENLSKPPS-- 384
Query: 384 REEQADSESSESLNFSEESPESPEDENSSSQE 415
+ +A+ E SE +EE P +P E S ++
Sbjct: 385 -DPEANPEVSERKLPTEEEP-APVVEQSGKRK 414
Score = 65.1 bits (157), Expect = 1e-10
Identities = 86/411 (20%), Positives = 159/411 (38%), Gaps = 40/411 (9%)
Query: 85 DKDDDED-------DSGDDTFGDDDSGPGPKDRQE---GGNSRLGSDEDSDDTIQASEES 134
+ ++DED S DDT G + PK + SR G S +A +
Sbjct: 13 EPEEDEDCYILNVQSSSDDTSGSSVARRAPKRQASCILNVQSRSGDTSGSSVARRAPKRQ 72
Query: 135 APQ----GQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGD 190
A DS ++ + + ++S E + + + SD ++ +
Sbjct: 73 ASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDN 132
Query: 191 GSELDDEGMQSDDPESIRSERGNSRM---NSAGMKSKESGENSEQANTQDSGGSQLLEHP 247
G++L+ SDD E+ +S NS ++ + + +A +S S + +
Sbjct: 133 GNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDN 192
Query: 248 SRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKE 307
S S DD S DDN+ +V D +++S+ D S D DS +DS+
Sbjct: 193 SDD----SSDDNSDDSS--DDNSDDSDVPDDKSDDSDVPDD--SSDDSDVPDDSSDDSEA 244
Query: 308 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDS 367
+ SS+ S+ + SS ++ + SE+ D+ D + + +D D
Sbjct: 245 PDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEAS-DDSSDDSE 303
Query: 368 SEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQ 427
+ +D S + +S + ++S+ L + + + +S E +++A SQ
Sbjct: 304 APDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQ 363
Query: 428 SEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 478
H DD+ QD + SK S+ + N E+ RKL +
Sbjct: 364 ----HDSSDDAGEQDLGENL-------SKPPSDPEA---NPEVSERKLPTE 400
Score = 65.1 bits (157), Expect = 1e-10
Identities = 68/298 (22%), Positives = 117/298 (39%), Gaps = 22/298 (7%)
Query: 84 DDKDDD--------EDDSGDDTFGDD--DSGPGPKDRQEGGNSRLGSDEDS---DDTIQA 130
DD DDD +D+S D DD D P D + + + +DS DD
Sbjct: 126 DDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDD 185
Query: 131 SEESAPQGQDSAQDTTSESRE--LDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH 188
S+ DS+ D + +S + D+ D D K + D +S S++ V S +S
Sbjct: 186 SDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDS-SDDSDVPDDSSDDSEA 244
Query: 189 GDGSELDDEGM--QSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH 246
D S D E SDD E+ +S E+ ++S + S E
Sbjct: 245 PDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSDDSEA 304
Query: 247 PSRKIFRKSRISEEDDRSELDDNNTME---EVKSDSTENSNSRDTGLSQPRRDSKGDSQE 303
P K ++ D S++ D+N+ + V ++ N + + + SQ
Sbjct: 305 PDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAEDLCNEGQIASDEEELVEAAAAVSQH 364
Query: 304 DSKENLSQEE-SQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE 360
DS ++ +++ +N+ P S+ +S ++ +E + V E G T + VE
Sbjct: 365 DSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEEPAPVVEQSGKRKSKTKTIVE 422
Score = 61.6 bits (148), Expect = 2e-09
Identities = 77/366 (21%), Positives = 146/366 (39%), Gaps = 44/366 (12%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
++ S+DSE + + P +D SD +++ + SDD + +
Sbjct: 140 DDNSDDSEAPDDNSDDSEAP----DDNSDDSEAPDD-NSDDSEAPDDNSDDSDVPDDNSD 194
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEES-APQGQDSA 142
D DD+ DDS DD D D P D+ + + S +DSD +S++S AP DS+
Sbjct: 195 DSSDDNSDDSSDDNSDDSDV---PDDKSDDSDVPDDSSDDSDVPDDSSDDSEAP--DDSS 249
Query: 143 QDTTSESRELDN----EDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEG 198
D+ + D+ +D D DS+ +SE+ + + S D DD+
Sbjct: 250 DDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEASDDSSDDSEASDDSSDDSEAPDDKS 309
Query: 199 MQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL-LEHPSRKIFRKSRI 257
SD PE + S+ ++ D L + P+ + + +I
Sbjct: 310 DDSDVPE----------------------DKSDDSDVPDDNSDDLEVPVPAEDLCNEGQI 347
Query: 258 SEEDDRSELDDNNTMEEVKSDSTENSNSRDTG--LSQPRRDSKGDSQEDSKENLSQEE-S 314
+ D EL + + DS++++ +D G LS+P D + + + ++ ++EE +
Sbjct: 348 A--SDEEELVEAAAAVS-QHDSSDDAGEQDLGENLSKPPSDPEANPEVSERKLPTEEEPA 404
Query: 315 QNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSH 374
V+ S+ + +++ + + E T + VE + ++ S
Sbjct: 405 PVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRKRQTKTKNIVEPLRKRKAKTKNVSV 464
Query: 375 TLSHSK 380
T H K
Sbjct: 465 TPGHKK 470
Score = 58.5 bits (140), Expect = 1e-08
Identities = 80/404 (19%), Positives = 155/404 (38%), Gaps = 46/404 (11%)
Query: 96 DTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSES------ 149
DT G + PK + +S + D DSD+ EE + + D S
Sbjct: 58 DTSGSSVARRAPKRQ---ASSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKP 114
Query: 150 ---------RELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQ 200
+ DN+D + E D + S+ + D SE D+
Sbjct: 115 AIQEPPIVISDDDNDDDNGNDLEVPDDNSDDSEAPDDNSDDSEAPDDNSDDSEAPDDNSD 174
Query: 201 SDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE 260
+ S+ + +++ S ++ ++S N+ DS + P K
Sbjct: 175 DSEAPDDNSDDSDVPDDNSDDSSDDNSDDSSDDNSDDS------DVPDDK---------S 219
Query: 261 DDRSELDDNNTMEEVKSDSTENSNSRDTGL--SQPRRDSKGDSQ--EDSKENLSQEESQN 316
DD DD++ +V DS+++S + D S+ DS DS+ +DS ++ + +
Sbjct: 220 DDSDVPDDSSDDSDVPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSSDDSEAPDDSS 279
Query: 317 VDGPSSESSQEANLSSQENS--SESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSH 374
D +S+ S + + +S ++S SE+ ++ +S S V D D +
Sbjct: 280 DDSEASDDSSDDSEASDDSSDDSEAPDDKSDDSDVPEDKSDDSDVPDDNSDDLEVPVPAE 339
Query: 375 TLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESH-- 432
L + + +E+ E++ +++ + S ++ E + E L S E+ E S
Sbjct: 340 DLCNEGQIASDEEELVEAAAAVSQHDSSDDAGEQDLG---ENLSKPPSDPEANPEVSERK 396
Query: 433 --SEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 474
+EE+ + + S ++ T + + + KNI RK
Sbjct: 397 LPTEEEPAPVVEQSGKRKSKTKTIVEPPRKRQTKTKNIVEPPRK 440
Score = 48.9 bits (115), Expect = 1e-05
Identities = 50/242 (20%), Positives = 99/242 (40%), Gaps = 25/242 (10%)
Query: 265 ELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSES 324
E D++ + V+S S + S S P+R + S+ + S P ++
Sbjct: 15 EEDEDCYILNVQSSSDDTSGS-SVARRAPKRQASCILNVQSRSGDTSGSSVARRAPKRQA 73
Query: 325 SQEANLSSQENSS----ESQEEVVSESRGDNPDPTTSYVED--QE-----DSDSSEEDSS 373
S + S + E ++ + E D+ P +V+ QE D +++D+
Sbjct: 74 SSVVVIDSDSDEECHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDNG 133
Query: 374 HTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHS 433
+ L S + +A ++S+ E+P D+NS E +S +E+ + S
Sbjct: 134 NDLEVPDDNSDDSEAPDDNSDD----SEAP----DDNSDDSEAPDDNSDDSEAPDDNS-- 183
Query: 434 EEDDSD-SQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDND 492
DDSD D+S D NS +S + +D + + + + + D+ + + D +D
Sbjct: 184 --DDSDVPDDNSDDSSDDNSDDSSDDNSDDSDVPDDKSDDSDVPDDSSDDSDVPDDSSDD 241
Query: 493 CQ 494
+
Sbjct: 242 SE 243
Score = 40.4 bits (93), Expect = 0.004
Identities = 33/140 (23%), Positives = 55/140 (39%), Gaps = 14/140 (10%)
Query: 364 DSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESP--------EDENSSSQE 415
DSDS EE HT K++ E +D ES E + E P +D+N + E
Sbjct: 80 DSDSDEE--CHTHEEKKAKLLEINSDDESPECCHVKPAIQEPPIVISDDDNDDDNGNDLE 137
Query: 416 GLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKL 475
+S +E+ + S DDS++ D + ++ S S D + ++
Sbjct: 138 VPDDNSDDSEAPDDNS----DDSEAPDDNSDDSEAPDDNSDDSEAPDDNSDDSDVPDDNS 193
Query: 476 TVDAYHNKPIGDQDDNDCQD 495
+ N D++D D
Sbjct: 194 DDSSDDNSDDSSDDNSDDSD 213
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 74.3 bits (181), Expect = 2e-13
Identities = 80/385 (20%), Positives = 151/385 (39%), Gaps = 43/385 (11%)
Query: 118 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 177
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHR 57
Query: 178 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQ--ANT 235
+ + S + ++D G + DD +I+ + SR + E + + +++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHS 115
Query: 236 QDSGGSQLLEHPSRKIFRKSRISEEDDRSELD-DNNTMEEVKSDSTENSNSRDTGLSQPR 294
+ G ++ R+ R+ R EE D++ + + E+ + + R L + R
Sbjct: 116 AEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR 175
Query: 295 RDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR----- 348
+ ++ ++ +E + + E +S+ + E + V S
Sbjct: 176 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 235
Query: 349 ----------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREEQA 388
GD P S ++D DS+ + + + S S S EE+
Sbjct: 236 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 295
Query: 389 DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS---- 444
+ E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 296 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 355
Query: 445 -----RSKEDSNSTESKSSSEEDGQ 464
S+ D +S ES+ + EE G+
Sbjct: 356 LLVVPESRFDRDSGESEEAEEEVGE 380
Score = 64.7 bits (156), Expect = 2e-10
Identities = 81/360 (22%), Positives = 128/360 (35%), Gaps = 22/360 (6%)
Query: 81 KGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQD 140
K DD+D D + D ++ + + DD++ ++
Sbjct: 36 KNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 95
Query: 141 SAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQ 200
E R+ R S EGG + E E E E + + +
Sbjct: 96 KVHHRKDEKRKEKRRHRSHSA-EGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 154
Query: 201 SDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE 260
E R ER R+ K + + EQ Q E R+ + R E
Sbjct: 155 EMAREHSRRER--DRLEQLERKRERERKMREQQKEQR-------EQKERERRAEERRKER 205
Query: 261 DDRSELDDNN-TMEEVKSDSTENSNSRDTGLSQPR-RDSKGDSQEDSKENLSQEESQNVD 318
+ R E+ ++ TM E SD + S+ + PR R GD ++ KE +E D
Sbjct: 206 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD 265
Query: 319 ----GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSH 374
S + A SS E+ S S+EE E + T+ E++E+ + EE+ +
Sbjct: 266 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 325
Query: 375 TLSHSKSE------SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQS 428
+ S SE S EE ++ E E+ N PES D +S E + QS
Sbjct: 326 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQS 385
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 73.9 bits (180), Expect = 3e-13
Identities = 82/374 (21%), Positives = 141/374 (37%), Gaps = 33/374 (8%)
Query: 118 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 177
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 178 V-----GGGSDGESSHGDGSELDDE-----GMQSDDPESI---RSERGNSRMNSAGMKSK 224
+ E S D E DD Q E + + E+ + A +K +
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER 117
Query: 225 ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN 284
E QD + R++ R+ E D +L+ E + +
Sbjct: 118 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE--QQKE 175
Query: 285 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQE--- 341
R+ + R + + +E +E + + D + + S E E
Sbjct: 176 QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGD 235
Query: 342 --EVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFS 399
+ V E + + D S ++D DS+ + + + S S S EE+ + E E +
Sbjct: 236 GRKPVKEEKMEERD-LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGST 294
Query: 400 EESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS---------RSKEDS 450
E E E+E +E S+S A QS E SEE+ S+ ++ S+ D
Sbjct: 295 SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDR 354
Query: 451 NSTESKSSSEEDGQ 464
+S ES+ + EE G+
Sbjct: 355 DSGESEEAEEEVGE 368
Score = 64.3 bits (155), Expect = 2e-10
Identities = 82/376 (21%), Positives = 140/376 (37%), Gaps = 34/376 (9%)
Query: 83 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 142
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 143 QDTTSESRELDNEDRVDSKPEGGDST--------QESESEEHWVGGGSDGESSHGDGSEL 194
+ T + ED ++ + E DS E H + H E
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER 117
Query: 195 DDEGMQSDDPESIRSERG---NSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKI 251
+ E + E ++ R R A S+ + EQ + ++ E +
Sbjct: 118 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 177
Query: 252 FRKSRISEEDDRSELDD--------NNTMEEVKSDSTENSNSRDTGLSQPR-RDSKGDSQ 302
+K R ++R + + + TM E SD + S+ + PR R GD +
Sbjct: 178 EQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGR 237
Query: 303 EDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSY 358
+ KE +E D S + A SS E+ S S+EE E + T+
Sbjct: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297
Query: 359 VEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEESPESPEDENSS 412
E++E+ + EE+ + + S SE S EE ++ E E+ N PES D +S
Sbjct: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 357
Query: 413 SQEGLQSHSSSAESQS 428
E + QS
Sbjct: 358 ESEEAEEEVGEGTPQS 373
>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
Length = 1163
Score = 73.6 bits (179), Expect = 4e-13
Identities = 105/486 (21%), Positives = 170/486 (34%), Gaps = 59/486 (12%)
Query: 28 EDSEEWKGHLAQAPTPPLANEDPS-------DSTQSEEGLGSDDHQYIYRLAGGFSRSTG 80
E + W L TP +PS +S QS G G + + G +
Sbjct: 322 EMTHSWPPPLTAIHTP--CKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSM 379
Query: 81 KGGDDKDDDEDDSGDDTFGDDD-------SGPGPKDRQEGGNSRLGSDEDSDDTIQASEE 133
KDD + S +D+ G+ D S PG NS G+D DD+ S
Sbjct: 380 L----KDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSE-GADNSRDDSSSHSGS 434
Query: 134 SAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSE 193
+ G DS +++S E NE + PE ++W+ + + S +
Sbjct: 435 ESSSGSDSESESSSSDSEA-NEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVD 493
Query: 194 LDDEGMQSDDPESIRSERGNSRMNSAGMKSKES---GENSEQANTQDSGGSQLLEHPSRK 250
+ Q E GNS +++G K S G +S+ G + P++
Sbjct: 494 SNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQS 553
Query: 251 IFRKSRISEEDDRSELDDNNTMEEVKSD-STENSNSRDTGLSQPRRDSKGDSQEDSKENL 309
R + + + + EE + E+ D S P K ++ K N+
Sbjct: 554 DSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNI 613
Query: 310 SQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPD--PTTSYVEDQEDSD- 366
+E + + + ++ S + S E E S S D + P +S +S+
Sbjct: 614 KKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNR 673
Query: 367 ------SSEEDSSHTLSHSKSESREEQADSESSE-----------SLNFSEESPESP--- 406
S EE+ S S E++ S SE LN P P
Sbjct: 674 TPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKE 733
Query: 407 -EDENSSSQEGLQSHSSSAESQSEES--------HSEEDDSDSQDSSRSK-EDSNSTESK 456
E + + H+ A+ Q+ E H EDD+ + +S + K ED NS K
Sbjct: 734 TEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHK 793
Query: 457 SSSEED 462
SS +
Sbjct: 794 PSSNRE 799
Score = 63.5 bits (153), Expect = 4e-10
Identities = 91/408 (22%), Positives = 147/408 (36%), Gaps = 65/408 (15%)
Query: 114 GNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESES 173
G + G D + + S +GQ ++ + S S KP+ S S S
Sbjct: 143 GTNSSGQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSS-------PGKPQAVSSLNSSHS 195
Query: 174 EEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGN-----------SRMNSA--- 219
H G H D D P + G S+ NS
Sbjct: 196 RSH---GNDHHSKEHQRSKSPRDPDANWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQK 252
Query: 220 ---------GMKSKESGENSEQANTQDSGGSQLLEHPSRKI-FRKSRI-SEEDDRSELDD 268
G +S E +SE ++Q G S PS K K +I S+ D S D
Sbjct: 253 PTAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSQPLDASASGD 312
Query: 269 NNTMEEVKSDSTENSNSRDTGLSQPRRDSKGD----SQEDSKENLSQEE------SQNVD 318
+ ++E+ + T + T + P + ++E + N E S+ +
Sbjct: 313 VSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTGEQKRYNPSKTSN 372
Query: 319 GPSSES--SQEANLSSQENSSESQE---EVVSESRGDNPDPTTSYVEDQEDSDSSEEDS- 372
G S+S + LSS E+S Q+ + + G N +P+ + E +D+S +DS
Sbjct: 373 GHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSH---HNSEGADNSRDDSS 429
Query: 373 ----SHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ-------SHS 421
S + S S SES +DSE++E + PE P L S +
Sbjct: 430 SHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPA 489
Query: 422 SSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIE 469
SS +S S + + Q + S D++ + SS+ K I+
Sbjct: 490 SSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQ 537
Score = 49.3 bits (116), Expect = 8e-06
Identities = 82/413 (19%), Positives = 155/413 (37%), Gaps = 54/413 (13%)
Query: 116 SRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEE 175
S LG+ ++ D I + S P+ + T S + + + GG S
Sbjct: 54 SMLGNYDEMKDFI--GDRSIPKLVAIPKPTVPPSADEKSNPNFFEQRHGG-----SHQSS 106
Query: 176 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKS-----KESGENS 230
W G +S S+ G+QS S +S NS+G + SG +S
Sbjct: 107 KWTPVGPAPSTSQ---SQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSS 163
Query: 231 EQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGL 290
+ S S+ K S ++ RS +D+++ E +S S + ++
Sbjct: 164 RKKGQHGSEHSKSRSSSPGKPQAVSSLNSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSP 223
Query: 291 SQPRRDSKGDSQEDSKENLSQEESQNVDGPSS-------ESSQEANLSSQENSSESQEEV 343
S+ S S + +L + + + P++ + S E LSS+ SS+S
Sbjct: 224 SRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAYVRPMDGQESMEPKLSSEHYSSQSHGNS 283
Query: 344 VSESRGDNPDPTTSYVEDQEDSDSSE-------EDSSHTLSHS------------KSESR 384
++E + + T + D+S ++ ++HS K+E
Sbjct: 284 MTELKPSSKAHLTKLKIPSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPS 343
Query: 385 EEQADSESSESLNF--SEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED------ 436
+ ++ S+ NF E+ +P ++ Q S SE+S E+D
Sbjct: 344 KFPFPTKESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMP 403
Query: 437 ----DSDSQDSSRSKEDSNSTESKSSSEEDGQLKN-IEIESRKLTVDAYHNKP 484
S+S+ S + E ++++ SSS + + + ES + D+ N+P
Sbjct: 404 RSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEP 456
Score = 47.4 bits (111), Expect = 3e-05
Identities = 105/476 (22%), Positives = 175/476 (36%), Gaps = 83/476 (17%)
Query: 25 NESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGD 84
+ S DSE + + +P P P++ Q + L + + + S G
Sbjct: 446 SSSSDSEANEPSQSASPEP---EPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGY 502
Query: 85 DKDDDEDDSGD---DTFGDDDSGPGPKDRQ--------EGGNSRLGSDEDSDDTIQASEE 133
K+ E +G+ DT G ++ R E G R S SD T Q
Sbjct: 503 KKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTV 562
Query: 134 SAPQGQDSAQDTTSESR---ELDNEDRVDS---------------------KPEGGDSTQ 169
Q + + + E R ++++E VD K E S +
Sbjct: 563 GKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPR 622
Query: 170 ESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGEN 229
+ ++ + + S + E D SD+ ES+ S +S +
Sbjct: 623 PTAEKKKYKSTSKSSQKSR-EIIETDTSSSDSDESESLPP----SSQTPKYPESNRTPVK 677
Query: 230 SEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTG 289
+DS Q + P + S +SE DDR L VK D N +R G
Sbjct: 678 PSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLI-------VKIDL--NLLTRIPG 728
Query: 290 LSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRG 349
+P ++++ E K+N+ ++ ++ +SE +N +++ SES+
Sbjct: 729 --KPYKETEPPKGE--KKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNR---ASESK- 780
Query: 350 DNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSES-LNFSEESP---ES 405
P T ED +S+ H S +RE S + E L S P +
Sbjct: 781 ---KPKT------EDKNSA--------GHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKD 823
Query: 406 PEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEE 461
P+ E+ S + + S SSS +S S S+ E S SS SK+ ++ SSS+E
Sbjct: 824 PKTEHGSRKRTI-SQSSSLKSSSN-SNKETSGSSKNSSSTSKQKKTEGKTSSSSKE 877
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/297 (21%), Positives = 112/297 (37%), Gaps = 41/297 (13%)
Query: 210 ERGNSRMNSAGMKSKES-GENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD 268
+R N S G +SK ++ + ++++DS G Q + + S SE D
Sbjct: 363 KRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGAD 422
Query: 269 NNTMEEVK---------SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDG 319
N+ + SDS S+S D+ ++P + + + + + N
Sbjct: 423 NSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVN 482
Query: 320 P---SSESSQEANL-SSQENSSESQEEVVSESRGDNPDPT-TSYVEDQEDSDSSEEDSSH 374
P S SS ++N+ SSQ E +E+ S D P TS DS + ++ S
Sbjct: 483 PHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSES 542
Query: 375 TLSHSKSESR------------------EEQADSESSESLNFSEESP-----ESPEDENS 411
KS ++ E+ A E L E+P P +
Sbjct: 543 GRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHK 602
Query: 412 SSQEGLQSHSSSAESQSEESHSEEDD---SDSQDSSRSKEDSNSTESKSSSEEDGQL 465
++ +G + + ES+S + E S S+ S +S+E + S S S+E L
Sbjct: 603 AATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESL 659
Score = 43.1 bits (100), Expect = 6e-04
Identities = 45/189 (23%), Positives = 70/189 (37%), Gaps = 27/189 (14%)
Query: 295 RDSKGDSQEDSKENLSQEESQNVDG----------PSSESSQEANLSSQENSSESQEEVV 344
R+ + + +E +QE Q D P +S+E LSS+ S + +
Sbjct: 3 REDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEM 62
Query: 345 SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE 404
+ GD P + S++E S+ EQ S +S ++ P
Sbjct: 63 KDFIGDRSIPKLVAIPKPTVPPSADEKSNPNFF--------EQRHGGSHQSSKWTPVGPA 114
Query: 405 SPEDENSSSQEGLQSH---------SSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTES 455
++ GLQS SSS + S + H E ++S SSR K S S
Sbjct: 115 PSTSQSQKRSSGLQSGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQHGSEHS 174
Query: 456 KSSSEEDGQ 464
KS S G+
Sbjct: 175 KSRSSSPGK 183
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 72.8 bits (177), Expect = 7e-13
Identities = 80/383 (20%), Positives = 147/383 (38%), Gaps = 50/383 (13%)
Query: 118 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 177
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 178 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 237
+ + S + ++D G + DD +I+ + SR + E + + A ++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKE 115
Query: 238 SGGSQLLEHPSRKIFRKSRISEEDDRSELD-DNNTMEEVKSDSTENSNSRDTGLSQPRRD 296
R+ R+ R EE D++ + + E+ + + R L + R
Sbjct: 116 K---------EREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 166
Query: 297 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR------- 348
+ ++ ++ +E + + E +S+ + E + V S
Sbjct: 167 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 226
Query: 349 --------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADS 390
GD P S ++D DS+ + + + S S S EE+ +
Sbjct: 227 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 286
Query: 391 ESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS------ 444
E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 287 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 346
Query: 445 ---RSKEDSNSTESKSSSEEDGQ 464
S+ D +S ES+ + EE G+
Sbjct: 347 VVPESRFDRDSGESEEAEEEVGE 369
Score = 64.3 bits (155), Expect = 2e-10
Identities = 81/377 (21%), Positives = 143/377 (37%), Gaps = 35/377 (9%)
Query: 83 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 142
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 143 QDTTSESRELDNEDRVDSKPEGGDSTQ----ESESEEHWVGGGSDGESSHGDGSELDDEG 198
+ T + ED ++ + E DS + S + V D + + + ++
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE 117
Query: 199 MQSDDPESIRSERGNSRMNSAGMKSKESGENS---------------EQANTQDSGGSQL 243
+ + + R E+ +R K +E E+ +
Sbjct: 118 REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQ 177
Query: 244 LEHPSRKIFRKSRISEEDDRSELDDNN-TMEEVKSDSTENSNSRDTGLSQPR-RDSKGDS 301
E R+ + R E + R E+ ++ TM E SD + S+ + PR R GD
Sbjct: 178 REQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 237
Query: 302 QEDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTS 357
++ KE +E D S + A SS E+ S S+EE E + T+
Sbjct: 238 RKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 297
Query: 358 YVEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEESPESPEDENS 411
E++E+ + EE+ + + S SE S EE ++ E E+ N PES D +S
Sbjct: 298 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDS 357
Query: 412 SSQEGLQSHSSSAESQS 428
E + QS
Sbjct: 358 GESEEAEEEVGEGTPQS 374
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 71.2 bits (173), Expect = 2e-12
Identities = 85/390 (21%), Positives = 149/390 (38%), Gaps = 42/390 (10%)
Query: 108 KDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESREL------DNEDRVDSK 161
++R+ + R + S + +EES+ + Q T+S+ + + N R +K
Sbjct: 1097 RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTK 1156
Query: 162 PEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGM 221
+ D T S S+ D ++S G+GS D + I+ N ++S
Sbjct: 1157 RKQADITSSSSSDIE-----DDDQNSIGEGSS---------DEQKIKPVTENLVLSSHTG 1202
Query: 222 KSKESGENSEQAN---TQDSGGSQLLEHPSRKIFRK-------SRISEEDDRSELDDNNT 271
+ SG+ + + T D P +I +K + +S ++D S D+
Sbjct: 1203 FCQSSGDEALSKSVPVTVDDDDDD--NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260
Query: 272 MEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK----ENLSQEESQNVDGPSSESSQE 327
++ E + + +Q +S DS+E K L + + DG S E +
Sbjct: 1261 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1320
Query: 328 ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQ 387
+E ++ +V SE D+ + E E S+S +E T S K+E E Q
Sbjct: 1321 KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE--EVSESEDEQRPRTRSAKKAELEENQ 1378
Query: 388 ADSESSES---LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS 444
+ + + E+S + + +E + E + EE E DDS S
Sbjct: 1379 RSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKG 1438
Query: 445 RSKEDSNSTESKSSSEEDGQLKNIEIESRK 474
R K + K +E LK E E RK
Sbjct: 1439 RKKIRKILKDDKLRTETQNALKE-EEERRK 1467
Score = 70.5 bits (171), Expect = 3e-12
Identities = 94/432 (21%), Positives = 169/432 (39%), Gaps = 54/432 (12%)
Query: 77 RSTGKGGDDKDDDEDDSGDDTFGDDDS-----GPGPKDRQEGGNS---RLGSDED----S 124
+STGKG ++ S + +G + G + RQ+ +S + ED S
Sbjct: 1028 KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS 1087
Query: 125 DDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDG 184
D ++ E + S ++T + D +S + Q + S++ V
Sbjct: 1088 DKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKK 1147
Query: 185 ESSHGDGSELDDEGMQSDDPESIRSERGNS--RMNSAGMKSKESGEN---SEQANTQDSG 239
+S ++ + S I + NS +S K K EN S S
Sbjct: 1148 RNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS 1207
Query: 240 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNT------MEEVKSD--STENSNSRDTGLS 291
G + L + ++ +DD + D N +EE+K++ S E+ +S D
Sbjct: 1208 GDEALS-------KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260
Query: 292 QPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ----------EANLSSQENSSESQE 341
+R K + + E + + D S ES + + +S E+ E +
Sbjct: 1261 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1320
Query: 342 EVVS--ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFS 399
+ E +G N +S ED EDSD E S +S S+ E R ++ +E
Sbjct: 1321 KPKEHKEVKGRNRRKVSS--EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAE----L 1374
Query: 400 EESPESPEDENSSSQEGLQSHSSS---AESQSEESHSEEDDSDSQDSSRSKEDSNSTESK 456
EE+ S + + + +Q SSS + S+ EE EE++ + ++ +ED N +SK
Sbjct: 1375 EENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND-DSK 1433
Query: 457 SSSEEDGQLKNI 468
S + +++ I
Sbjct: 1434 SPGKGRKKIRKI 1445
Score = 64.7 bits (156), Expect = 2e-10
Identities = 79/363 (21%), Positives = 138/363 (38%), Gaps = 44/363 (12%)
Query: 39 QAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDE--DDSGDD 96
QA ++ D D Q+ G GS D Q I + S+ G DE S
Sbjct: 1159 QADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPV 1218
Query: 97 TFGDDDSGPGPKDR------QEGGNSRLGSDED---SDDTIQASEESAPQGQDSAQDTTS 147
T DDD P++R E + L SDED D+ + + + Q +++ D +
Sbjct: 1219 TVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1278
Query: 148 ESR---ELDNEDRVDSKP-------------EGGDSTQESES--EEHWVGGGSDGESSHG 189
+++ E D++ KP G+S +E ++ +EH G +
Sbjct: 1279 KNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS 1338
Query: 190 DGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSR 249
+ SE D + +S E + R + K E EN +++ Q ++
Sbjct: 1339 EDSE-DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEEN-QRSYKQKKKRRRIKVQEDS 1396
Query: 250 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQP--RRDSKGDSQEDSKE 307
KS EE++ E ++ EE + + EN +S+ G + R+ K D +
Sbjct: 1397 SSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQ 1456
Query: 308 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS-ESRGDNPDPTTSYVEDQEDSD 366
N +EE + + ++ +E E EV+ E P T+ + ED +
Sbjct: 1457 NALKEEEE----------RRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1506
Query: 367 SSE 369
+ E
Sbjct: 1507 TKE 1509
Score = 62.4 bits (150), Expect = 9e-10
Identities = 86/378 (22%), Positives = 156/378 (41%), Gaps = 44/378 (11%)
Query: 122 EDSDDTIQASEESAPQG-QDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 180
+ SD+T + ++ + +G ++ + + + + + E + +S +G + E E H+ G
Sbjct: 934 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 993
Query: 181 GSDGESSHGDGSE----LDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQ 236
++ DG + + D+ + D S +E+ + +S +S E+ + N
Sbjct: 994 IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC-----DSSEDKKSKN-- 1046
Query: 237 DSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD 296
G+ E K+ KS +D S + +M+E + NS D L R +
Sbjct: 1047 ---GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKE------DGCNSSDKRLK--RIE 1095
Query: 297 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT 356
+ SK N + +S + + ESS++ Q SS+ + +V E + ++ T
Sbjct: 1096 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL--RT 1153
Query: 357 SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS--SSQ 414
S Q D SS S + + D ++S S+E P EN SS
Sbjct: 1154 STKRKQADITSSS-------------SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1200
Query: 415 EGL-QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKS--SSEEDGQLKNIEIE 471
G QS A S+S ++DD D+ +R + E K+ SS+EDG + E
Sbjct: 1201 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1260
Query: 472 SRKLTVDAYHNKPIGDQD 489
+K T P GD++
Sbjct: 1261 GKKRTGKQNEENP-GDEE 1277
Score = 57.4 bits (137), Expect = 3e-08
Identities = 99/478 (20%), Positives = 185/478 (38%), Gaps = 50/478 (10%)
Query: 16 ALPVTRYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGF 75
++PV + S DS A P N+ P S QSE + D + +
Sbjct: 654 SVPVRKKDKRNSSDS---------AIDNPKPNKLPK-SKQSETVDQNSDSDEMLAILKEV 703
Query: 76 SRSTGKGGDDKDDDEDDSGDDTFGD--DDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEE 133
SR + D D +E + T D +G K +++ +S GSD D+ A
Sbjct: 704 SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSS 763
Query: 134 SAPQGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQE----------SESEEHWVGG-- 180
+ + Q +S EL+ E + SK +T++ SE E+H G
Sbjct: 764 IISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMD 823
Query: 181 --GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDS 238
G + +GS D E Q + E+ S G ++ M+ ++ +QA+
Sbjct: 824 NQGHKNLKTSQEGSSDDAERKQ--ERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTD 881
Query: 239 GGSQLL-EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS 297
G +L + S +++E ++S+ T ++V+ + D ++D
Sbjct: 882 GVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS------DIAEKFLKKDQ 935
Query: 298 KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTS 357
++ ED K+ S++ ++ PS + + Q SS E + E P
Sbjct: 936 SDETSEDDKKQ-SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG- 993
Query: 358 YVEDQEDSDSSEEDSSHTLSHSKSESREEQAD-SESSESLNFSEESPESPEDENSSSQEG 416
++ ++ + E S + S+ ++E +D +E S S +S E + +N + G
Sbjct: 994 -IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAY--G 1050
Query: 417 LQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 474
+ +S + SD++ S ++ NS+ D +LK IE+ R+
Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS--------DKRLKRIELRERR 1100
Score = 45.1 bits (105), Expect = 2e-04
Identities = 72/336 (21%), Positives = 118/336 (35%), Gaps = 40/336 (11%)
Query: 144 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 203
D+ + + E++ +K GG+ + EE + E ++D + S
Sbjct: 432 DSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDL-----DMDIVSVPSSV 486
Query: 204 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 263
PE I + + + + G SG Q +E S K+ IS +D+R
Sbjct: 487 PEDIFENLETAMEVQSSVDHQGDGS---------SGTEQEVESSSVKL----NISSKDNR 533
Query: 264 SELDDNNTMEEVKS-------DSTENSNSRDTGLSQPRRD-----SKGDSQEDSKENLSQ 311
+ T + K S NS + + +D S G + + K L Q
Sbjct: 534 GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQ 593
Query: 312 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 371
E S N +E S S S + + NP + S E E ++
Sbjct: 594 ENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 653
Query: 372 SSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGL--------QSHSSS 423
S K S + D+ L S++S D+NS S E L SHSSS
Sbjct: 654 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQS--ETVDQNSDSDEMLAILKEVSRMSHSSS 711
Query: 424 AESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSS 459
+++ E H+ + K+D + KSS+
Sbjct: 712 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST 747
Score = 38.5 bits (88), Expect = 0.014
Identities = 74/395 (18%), Positives = 143/395 (36%), Gaps = 35/395 (8%)
Query: 67 YIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDD 126
Y+ S S KG D ++ +D G + G PK + G LG + ++
Sbjct: 549 YVKLTPVSLSNSPIKGADCQEVPQDKDGYKS-----CGLNPKLEKCG----LGQENSDNE 599
Query: 127 TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGES 186
+ +E S E +L RV + P +E + V SD E
Sbjct: 600 HLVENEVSL----------LLEESDLRRSPRVKTTP------LRRPTETNPVTSNSDEEC 643
Query: 187 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH 246
+ E E + P + +R +S K + ++ + + S +
Sbjct: 644 N-----ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLA 698
Query: 247 PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK 306
+++ R S S D +++++ +T + D + D G + R+ S S D+K
Sbjct: 699 ILKEVSRMSHSSSSD--TDINEIHTNHKTLYDLKTQAGKDDKG-KRKRKSSTSGSDFDTK 755
Query: 307 ENLSQEESQNVDGPSSESSQEANLSSQ-ENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 365
+ S + S S+ +N S+ E +S ++ + P T + ED
Sbjct: 756 KGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE 815
Query: 366 DSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAE 425
S++ + + S+E +D + + S E D++++ E L+ +
Sbjct: 816 KHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME-LRDRLPKKQ 874
Query: 426 SQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 460
S + + S + S S E E+K S+
Sbjct: 875 QASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSK 909
Score = 38.1 bits (87), Expect = 0.019
Identities = 67/321 (20%), Positives = 119/321 (37%), Gaps = 34/321 (10%)
Query: 205 ESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRS 264
+S +S + + K S N E+ DS + S I K I +
Sbjct: 263 DSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLI 322
Query: 265 ELDDNNTMEEVK--SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN-----V 317
E N VK +T+NS + + K + K +L+ EE N +
Sbjct: 323 ETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAM 382
Query: 318 DGPSSESSQE------------ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 365
D + E + + A + + E ++ SE++ + ++ +
Sbjct: 383 DAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPT 442
Query: 366 DSSEEDSSHTLSHSKSESREE--QADSESSESLNFSEESPES--PED--ENSSSQEGLQS 419
+ + S H KS+ +EE + +SE L+ S S PED EN + +QS
Sbjct: 443 EEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQS 502
Query: 420 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDA 479
S + E + S + + SK++ +SK++++ +L KLT +
Sbjct: 503 SVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKEL------YVKLTPVS 556
Query: 480 YHNKPIGDQDDNDC---QDGY 497
N PI D + +DGY
Sbjct: 557 LSNSPIKGADCQEVPQDKDGY 577
Score = 36.2 bits (82), Expect = 0.071
Identities = 31/147 (21%), Positives = 52/147 (35%), Gaps = 7/147 (4%)
Query: 283 SNSRDTGLSQPRRDSKGDSQEDSKENLS------QEESQNVDGPSSESSQEANLSSQENS 336
S S+ L Q D S E+S+E S + + + G S S N + S
Sbjct: 7 SESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTS 66
Query: 337 SESQEEVVSESRGDN-PDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSES 395
S + + SR P T YVE ++ +E + S+ SE+ +
Sbjct: 67 SSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKEDG 126
Query: 396 LNFSEESPESPEDENSSSQEGLQSHSS 422
L+ + N ++ + H S
Sbjct: 127 LHGIVSCTACGQQVNHFQKDSIYRHPS 153
Score = 35.0 bits (79), Expect = 0.16
Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 14/107 (13%)
Query: 196 DEGMQSDDPESIRSERGNSRMNSAGMKS------KESGENSEQANTQDSGGSQLLEHPSR 249
+E ++ P + + +++ +G S KE G +S + ++ SG S+ PS
Sbjct: 27 EESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSE-KSKSSGSSRSKRKPSI 85
Query: 250 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD 296
++ E DD LDD E+ S ENS + T S P+ D
Sbjct: 86 V----TKYVESDDEKPLDDETVNEDA---SNENSENDITMQSLPKED 125
Score = 32.3 bits (72), Expect = 1.0
Identities = 23/101 (22%), Positives = 42/101 (41%), Gaps = 2/101 (1%)
Query: 365 SDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSA 424
S+ SEE SS + + +S+ + S+E S +++ SS S
Sbjct: 26 SEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSEKSKSSGSSRSKRKPSI 85
Query: 425 ESQSEESHSEE--DDSDSQDSSRSKEDSNSTESKSSSEEDG 463
++ ES E+ DD + + ++ N +S +EDG
Sbjct: 86 VTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKEDG 126
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 71.2 bits (173), Expect = 2e-12
Identities = 85/390 (21%), Positives = 149/390 (38%), Gaps = 42/390 (10%)
Query: 108 KDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESREL------DNEDRVDSK 161
++R+ + R + S + +EES+ + Q T+S+ + + N R +K
Sbjct: 1135 RERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTK 1194
Query: 162 PEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGM 221
+ D T S S+ D ++S G+GS D + I+ N ++S
Sbjct: 1195 RKQADITSSSSSDIE-----DDDQNSIGEGSS---------DEQKIKPVTENLVLSSHTG 1240
Query: 222 KSKESGENSEQAN---TQDSGGSQLLEHPSRKIFRK-------SRISEEDDRSELDDNNT 271
+ SG+ + + T D P +I +K + +S ++D S D+
Sbjct: 1241 FCQSSGDEALSKSVPVTVDDDDDD--NDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298
Query: 272 MEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK----ENLSQEESQNVDGPSSESSQE 327
++ E + + +Q +S DS+E K L + + DG S E +
Sbjct: 1299 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1358
Query: 328 ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQ 387
+E ++ +V SE D+ + E E S+S +E T S K+E E Q
Sbjct: 1359 KPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSE--EVSESEDEQRPRTRSAKKAELEENQ 1416
Query: 388 ADSESSES---LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS 444
+ + + E+S + + +E + E + EE E DDS S
Sbjct: 1417 RSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKG 1476
Query: 445 RSKEDSNSTESKSSSEEDGQLKNIEIESRK 474
R K + K +E LK E E RK
Sbjct: 1477 RKKIRKILKDDKLRTETQNALKE-EEERRK 1505
Score = 70.5 bits (171), Expect = 3e-12
Identities = 94/432 (21%), Positives = 169/432 (39%), Gaps = 54/432 (12%)
Query: 77 RSTGKGGDDKDDDEDDSGDDTFGDDDS-----GPGPKDRQEGGNS---RLGSDED----S 124
+STGKG ++ S + +G + G + RQ+ +S + ED S
Sbjct: 1066 KSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS 1125
Query: 125 DDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDG 184
D ++ E + S ++T + D +S + Q + S++ V
Sbjct: 1126 DKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKK 1185
Query: 185 ESSHGDGSELDDEGMQSDDPESIRSERGNS--RMNSAGMKSKESGEN---SEQANTQDSG 239
+S ++ + S I + NS +S K K EN S S
Sbjct: 1186 RNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSS 1245
Query: 240 GSQLLEHPSRKIFRKSRISEEDDRSELDDNNT------MEEVKSD--STENSNSRDTGLS 291
G + L + ++ +DD + D N +EE+K++ S E+ +S D
Sbjct: 1246 GDEALS-------KSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298
Query: 292 QPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ----------EANLSSQENSSESQE 341
+R K + + E + + D S ES + + +S E+ E +
Sbjct: 1299 GKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT 1358
Query: 342 EVVS--ESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFS 399
+ E +G N +S ED EDSD E S +S S+ E R ++ +E
Sbjct: 1359 KPKEHKEVKGRNRRKVSS--EDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAE----L 1412
Query: 400 EESPESPEDENSSSQEGLQSHSSS---AESQSEESHSEEDDSDSQDSSRSKEDSNSTESK 456
EE+ S + + + +Q SSS + S+ EE EE++ + ++ +ED N +SK
Sbjct: 1413 EENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDEND-DSK 1471
Query: 457 SSSEEDGQLKNI 468
S + +++ I
Sbjct: 1472 SPGKGRKKIRKI 1483
Score = 64.7 bits (156), Expect = 2e-10
Identities = 79/363 (21%), Positives = 138/363 (38%), Gaps = 44/363 (12%)
Query: 39 QAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDE--DDSGDD 96
QA ++ D D Q+ G GS D Q I + S+ G DE S
Sbjct: 1197 QADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPV 1256
Query: 97 TFGDDDSGPGPKDR------QEGGNSRLGSDED---SDDTIQASEESAPQGQDSAQDTTS 147
T DDD P++R E + L SDED D+ + + + Q +++ D +
Sbjct: 1257 TVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1316
Query: 148 ESR---ELDNEDRVDSKP-------------EGGDSTQESES--EEHWVGGGSDGESSHG 189
+++ E D++ KP G+S +E ++ +EH G +
Sbjct: 1317 KNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSS 1376
Query: 190 DGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSR 249
+ SE D + +S E + R + K E EN +++ Q ++
Sbjct: 1377 EDSE-DSDFQESGVSEEVSESEDEQRPRTRSAKKAELEEN-QRSYKQKKKRRRIKVQEDS 1434
Query: 250 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQP--RRDSKGDSQEDSKE 307
KS EE++ E ++ EE + + EN +S+ G + R+ K D +
Sbjct: 1435 SSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQ 1494
Query: 308 NLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVS-ESRGDNPDPTTSYVEDQEDSD 366
N +EE + + ++ +E E EV+ E P T+ + ED +
Sbjct: 1495 NALKEEEE----------RRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEE 1544
Query: 367 SSE 369
+ E
Sbjct: 1545 TKE 1547
Score = 62.4 bits (150), Expect = 9e-10
Identities = 86/378 (22%), Positives = 156/378 (41%), Gaps = 44/378 (11%)
Query: 122 EDSDDTIQASEESAPQG-QDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 180
+ SD+T + ++ + +G ++ + + + + + E + +S +G + E E H+ G
Sbjct: 972 DQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG 1031
Query: 181 GSDGESSHGDGSE----LDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQ 236
++ DG + + D+ + D S +E+ + +S +S E+ + N
Sbjct: 1032 IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSC-----DSSEDKKSKN-- 1084
Query: 237 DSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRD 296
G+ E K+ KS +D S + +M+E + NS D L R +
Sbjct: 1085 ---GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKE------DGCNSSDKRLK--RIE 1133
Query: 297 SKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT 356
+ SK N + +S + + ESS++ Q SS+ + +V E + ++ T
Sbjct: 1134 LRERRNLSSKRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSL--RT 1191
Query: 357 SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENS--SSQ 414
S Q D SS S + + D ++S S+E P EN SS
Sbjct: 1192 STKRKQADITSSS-------------SSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSH 1238
Query: 415 EGL-QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKS--SSEEDGQLKNIEIE 471
G QS A S+S ++DD D+ +R + E K+ SS+EDG + E
Sbjct: 1239 TGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEE 1298
Query: 472 SRKLTVDAYHNKPIGDQD 489
+K T P GD++
Sbjct: 1299 GKKRTGKQNEENP-GDEE 1315
Score = 57.4 bits (137), Expect = 3e-08
Identities = 99/478 (20%), Positives = 185/478 (38%), Gaps = 50/478 (10%)
Query: 16 ALPVTRYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGF 75
++PV + S DS A P N+ P S QSE + D + +
Sbjct: 692 SVPVRKKDKRNSSDS---------AIDNPKPNKLPK-SKQSETVDQNSDSDEMLAILKEV 741
Query: 76 SRSTGKGGDDKDDDEDDSGDDTFGD--DDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEE 133
SR + D D +E + T D +G K +++ +S GSD D+ A
Sbjct: 742 SRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSS 801
Query: 134 SAPQGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQE----------SESEEHWVGG-- 180
+ + Q +S EL+ E + SK +T++ SE E+H G
Sbjct: 802 IISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMD 861
Query: 181 --GSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDS 238
G + +GS D E Q + E+ S G ++ M+ ++ +QA+
Sbjct: 862 NQGHKNLKTSQEGSSDDAERKQ--ERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTD 919
Query: 239 GGSQLL-EHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDS 297
G +L + S +++E ++S+ T ++V+ + D ++D
Sbjct: 920 GVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQDGLS------DIAEKFLKKDQ 973
Query: 298 KGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTS 357
++ ED K+ S++ ++ PS + + Q SS E + E P
Sbjct: 974 SDETSEDDKKQ-SKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHFPKG- 1031
Query: 358 YVEDQEDSDSSEEDSSHTLSHSKSESREEQAD-SESSESLNFSEESPESPEDENSSSQEG 416
++ ++ + E S + S+ ++E +D +E S S +S E + +N + G
Sbjct: 1032 -IKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAY--G 1088
Query: 417 LQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRK 474
+ +S + SD++ S ++ NS+ D +LK IE+ R+
Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSS--------DKRLKRIELRERR 1138
Score = 45.1 bits (105), Expect = 2e-04
Identities = 72/336 (21%), Positives = 118/336 (35%), Gaps = 40/336 (11%)
Query: 144 DTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDD 203
D+ + + E++ +K GG+ + EE + E ++D + S
Sbjct: 470 DSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDL-----DMDIVSVPSSV 524
Query: 204 PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDR 263
PE I + + + + G SG Q +E S K+ IS +D+R
Sbjct: 525 PEDIFENLETAMEVQSSVDHQGDGS---------SGTEQEVESSSVKL----NISSKDNR 571
Query: 264 SELDDNNTMEEVKS-------DSTENSNSRDTGLSQPRRD-----SKGDSQEDSKENLSQ 311
+ T + K S NS + + +D S G + + K L Q
Sbjct: 572 GGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQ 631
Query: 312 EESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEED 371
E S N +E S S S + + NP + S E E ++
Sbjct: 632 ENSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKL 691
Query: 372 SSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGL--------QSHSSS 423
S K S + D+ L S++S D+NS S E L SHSSS
Sbjct: 692 SVPVRKKDKRNSSDSAIDNPKPNKLPKSKQS--ETVDQNSDSDEMLAILKEVSRMSHSSS 749
Query: 424 AESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSS 459
+++ E H+ + K+D + KSS+
Sbjct: 750 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSST 785
Score = 38.5 bits (88), Expect = 0.014
Identities = 74/395 (18%), Positives = 143/395 (36%), Gaps = 35/395 (8%)
Query: 67 YIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDD 126
Y+ S S KG D ++ +D G + G PK + G LG + ++
Sbjct: 587 YVKLTPVSLSNSPIKGADCQEVPQDKDGYKS-----CGLNPKLEKCG----LGQENSDNE 637
Query: 127 TIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGES 186
+ +E S E +L RV + P +E + V SD E
Sbjct: 638 HLVENEVSL----------LLEESDLRRSPRVKTTP------LRRPTETNPVTSNSDEEC 681
Query: 187 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEH 246
+ E E + P + +R +S K + ++ + + S +
Sbjct: 682 N-----ETVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLA 736
Query: 247 PSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK 306
+++ R S S D +++++ +T + D + D G + R+ S S D+K
Sbjct: 737 ILKEVSRMSHSSSSD--TDINEIHTNHKTLYDLKTQAGKDDKG-KRKRKSSTSGSDFDTK 793
Query: 307 ENLSQEESQNVDGPSSESSQEANLSSQ-ENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 365
+ S + S S+ +N S+ E +S ++ + P T + ED
Sbjct: 794 KGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDFDSSEDE 853
Query: 366 DSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAE 425
S++ + + S+E +D + + S E D++++ E L+ +
Sbjct: 854 KHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKDTTIME-LRDRLPKKQ 912
Query: 426 SQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSE 460
S + + S + S S E E+K S+
Sbjct: 913 QASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSK 947
Score = 38.1 bits (87), Expect = 0.019
Identities = 67/321 (20%), Positives = 119/321 (37%), Gaps = 34/321 (10%)
Query: 205 ESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRS 264
+S +S + + K S N E+ DS + S I K I +
Sbjct: 301 DSEKSNKVYEHTSRFSPKKTSSNCNGEEKKLDDSCSGSVTYSYSALIVPKEMIKKAKKLI 360
Query: 265 ELDDNNTMEEVK--SDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN-----V 317
E N VK +T+NS + + K + K +L+ EE N +
Sbjct: 361 ETTANMNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAM 420
Query: 318 DGPSSESSQE------------ANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 365
D + E + + A + + E ++ SE++ + ++ +
Sbjct: 421 DAVNKEKNTKEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPT 480
Query: 366 DSSEEDSSHTLSHSKSESREE--QADSESSESLNFSEESPES--PED--ENSSSQEGLQS 419
+ + S H KS+ +EE + +SE L+ S S PED EN + +QS
Sbjct: 481 EEQRTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQS 540
Query: 420 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDA 479
S + E + S + + SK++ +SK++++ +L KLT +
Sbjct: 541 SVDHQGDGSSGTEQEVESSSVKLNISSKDNRGGIKSKTTAKVTKEL------YVKLTPVS 594
Query: 480 YHNKPIGDQDDNDC---QDGY 497
N PI D + +DGY
Sbjct: 595 LSNSPIKGADCQEVPQDKDGY 615
Score = 36.6 bits (83), Expect = 0.054
Identities = 37/164 (22%), Positives = 59/164 (35%), Gaps = 3/164 (1%)
Query: 300 DSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV 359
+ +SK N ++ + SSE S+E SS + +Q G N D +
Sbjct: 4 EPMSESKLNTLVQKLHDFLAHSSEESEET--SSPPRLAMNQNTDKISGSGSNSDMMENSK 61
Query: 360 EDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQS 419
E+ S + S + S K + +S+ + L+ E E +ENS + +QS
Sbjct: 62 EEGTSSSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLD-DETVNEDASNENSENDITMQS 120
Query: 420 HSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDG 463
E ED D + TE+ EDG
Sbjct: 121 LPKGTVIVQPEPVLNEDKDDFKGPEFRSRSKMKTENLKKRGEDG 164
Score = 36.2 bits (82), Expect = 0.071
Identities = 38/181 (20%), Positives = 63/181 (34%), Gaps = 30/181 (16%)
Query: 283 SNSRDTGLSQPRRDSKGDSQEDSKENLS------QEESQNVDGPSSESSQEANLSSQENS 336
S S+ L Q D S E+S+E S + + + G S S N + S
Sbjct: 7 SESKLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTS 66
Query: 337 SESQEEVVSESRGDN-PDPTTSYVEDQEDSDSSEEDSSHTLSHSKSES------------ 383
S + + SR P T YVE ++ +E + S+ SE+
Sbjct: 67 SSEKSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTV 126
Query: 384 --------REEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 435
E++ D + E F S E+ ++GL S + +H ++
Sbjct: 127 IVQPEPVLNEDKDDFKGPE---FRSRSKMKTENLKKRGEDGLHGIVSCTACGQQVNHFQK 183
Query: 436 D 436
D
Sbjct: 184 D 184
Score = 35.4 bits (80), Expect = 0.12
Identities = 30/136 (22%), Positives = 61/136 (44%), Gaps = 19/136 (13%)
Query: 196 DEGMQSDDPESIRSERGNSRMNSAGMKS------KESGENSEQANTQDSGGSQLLEHPSR 249
+E ++ P + + +++ +G S KE G +S + ++ SG S+ PS
Sbjct: 27 EESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSE-KSKSSGSSRSKRKPSI 85
Query: 250 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN-----SNSRDTGLSQPR---RDSKGDS 301
++ E DD LDD E+ ++++EN S + T + QP + K D
Sbjct: 86 V----TKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQPEPVLNEDKDDF 141
Query: 302 QEDSKENLSQEESQNV 317
+ + S+ +++N+
Sbjct: 142 KGPEFRSRSKMKTENL 157
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 71.2 bits (173), Expect = 2e-12
Identities = 84/387 (21%), Positives = 147/387 (37%), Gaps = 49/387 (12%)
Query: 118 LGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHW 177
+G ++DS E + + Q+ +E + L N D DSK DS +E E +H
Sbjct: 1 MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR---DSLEEGELRDHC 57
Query: 178 VGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 237
+ + S + ++D G + DD +I+ + SR + E + + A ++
Sbjct: 58 MEI-TIRNSPYRREDSMEDRG-EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKE 115
Query: 238 SGGSQLLEHPSRKIFRKS-----RISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQ 292
EH RK R+ R E R E+ ++ E +D R L +
Sbjct: 116 KER----EHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLER 171
Query: 293 PRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS-ESQEEVVSESR--- 348
R + ++ ++ +E + + E +S+ + E + V S
Sbjct: 172 KRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSR 231
Query: 349 ------------GDNPDPTT----------SYVEDQEDSDSSEEDSSHTLSHSKSESREE 386
GD P S ++D DS+ + + + S S S EE
Sbjct: 232 SPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 291
Query: 387 QADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS-- 444
+ + E E + E E E+E +E S+S A QS E SEE+ S+ ++
Sbjct: 292 EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 351
Query: 445 -------RSKEDSNSTESKSSSEEDGQ 464
S+ D +S ES+ + EE G+
Sbjct: 352 NHLLVVPESRFDRDSGESEEAEEEVGE 378
Score = 63.5 bits (153), Expect = 4e-10
Identities = 84/386 (21%), Positives = 146/386 (37%), Gaps = 44/386 (11%)
Query: 83 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 142
GD+KD + + D+ + +++ E RL + +D D + EE + +D
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAE--IKRLKNSDDRDSKRDSLEEG--ELRDHC 57
Query: 143 QDTTSESRELDNEDRVDSKPEGGDSTQ----ESESEEHWVGGGSDGESSHGDGSELDDEG 198
+ T + ED ++ + E DS + S + V D + + + ++
Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE 117
Query: 199 MQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQL---LEHPSRKIFRKS 255
+ + + R E+ +R K +E + + G LE RK R+
Sbjct: 118 REHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERER 177
Query: 256 RISE---------------EDDRSELD-------DNNTMEEVKSDSTENSNSRDTGLSQP 293
++ E E+ R E + + TM E SD + S+ + P
Sbjct: 178 KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237
Query: 294 R-RDSKGDSQEDSKENLSQEESQNVD----GPSSESSQEANLSSQENSSESQEEVVSESR 348
R R GD ++ KE +E D S + A SS E+ S S+EE E
Sbjct: 238 RERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEE 297
Query: 349 GDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE------SREEQADSESSESLNFSEES 402
+ T+ E++E+ + EE+ + + S SE S EE ++ E E+ N
Sbjct: 298 EEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVV 357
Query: 403 PESPEDENSSSQEGLQSHSSSAESQS 428
PES D +S E + QS
Sbjct: 358 PESRFDRDSGESEEAEEEVGEGTPQS 383
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 70.9 bits (172), Expect = 3e-12
Identities = 84/323 (26%), Positives = 129/323 (39%), Gaps = 31/323 (9%)
Query: 147 SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPES 206
S SR R G + S+S G S + + S
Sbjct: 192 SRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRS--KKEKSRS 249
Query: 207 IRSERGNSRMNSAGM-KSKESGENSEQANTQDSGGSQLLEHPSR-KIFRKSRISEEDDRS 264
E+ SR +SAG +SK + E+ D+ G PSR K KSR ++ R
Sbjct: 250 PSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERR- 308
Query: 265 ELDDNNTMEEVKSDSTENSNSRDTGL--SQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 322
+EE K S S++ L S+ R SKG S+ S+ ++ +
Sbjct: 309 -------VEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRK----GR 357
Query: 323 ESSQEANLSSQENSSESQEEVVSESRGDNPDPT--TSYVEDQEDSDSSEEDS-----SHT 375
+ S+E + S + S+S+ S RG D +S + +ED+D S+ S S
Sbjct: 358 KRSREESRSRSRSRSKSER---SRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKE 414
Query: 376 LSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 435
H+KSES + + E SE+ ++E+ S NS S+ L S S S + ++ S
Sbjct: 415 REHAKSESSQREGRGE-SENAGTNQET-RSRSRSNSKSKPNLPSESRSRSKSASKTRS-R 471
Query: 436 DDSDSQDSSRSKEDSNSTESKSS 458
S S+ +SRS S S S
Sbjct: 472 SKSRSRSASRSPSRSRSRSHSRS 494
Score = 68.6 bits (166), Expect = 1e-11
Identities = 86/397 (21%), Positives = 141/397 (35%), Gaps = 27/397 (6%)
Query: 95 DDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDN 154
D ++G SG G + G + G ++ + S+ +D ++ E+
Sbjct: 76 DGSYGSGRSGYGYR---RSGRDKYGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTY 132
Query: 155 EDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNS 214
D + G S S+ DG +G L ++ S S R +S
Sbjct: 133 ADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHS 192
Query: 215 RMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEE 274
R S S++S S + + S SR SR S+ RS+ + E+
Sbjct: 193 RSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSR-----SR-SKSRSRSQSRSRSKKEK 246
Query: 275 VKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQE 334
+S S E S SR + R SK ++E + N NV P S S S+
Sbjct: 247 SRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNN------DNVGKPKSRSPSRHKSKSKS 300
Query: 335 NSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSE 394
S + V E RG + S QE S S + S+S SR + +
Sbjct: 301 RSRSQERRVEEEKRG-----SVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRK 355
Query: 395 SLNFSEESPESPEDENSSSQEGLQSHS-------SSAESQSEESHSEEDDSDSQDSSRSK 447
S E S S S+ + S SS + + E++ + S S+ S+ +
Sbjct: 356 GRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKER 415
Query: 448 EDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKP 484
E + S S+ + + E+R + +KP
Sbjct: 416 EHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKP 452
>gi|50962882 G patch domain containing 8 [Homo sapiens]
Length = 1502
Score = 70.5 bits (171), Expect = 3e-12
Identities = 87/430 (20%), Positives = 160/430 (37%), Gaps = 28/430 (6%)
Query: 54 TQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEG 113
T+ + +GS ++ L G + + G +K D + G ++QE
Sbjct: 589 TEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGEKIVRSSGGRMDAPASGSACSG-LNKQEP 647
Query: 114 GNSRLGSDEDSDDTIQASEESAPQG-------QDSAQDTTSESRELDNEDRVDSKPEGGD 166
G S ED+ ++ + +E + + + + D E++ SK E G+
Sbjct: 648 GGSHGSETEDTGRSLPSKKERSGKSHRHKKKKKHKKSSKHKRKHKADTEEK-SSKAESGE 706
Query: 167 STQESESEEHWVGGGS-DGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKE 225
+++ + + S +S G E G + P R + +S+ S +
Sbjct: 707 KSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAP-PRRRRRAQDDSQRRSLPAEEGS 765
Query: 226 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED-------DRSELDDNNTMEEVKSD 278
SG+ E GGS +H RK K + RS + + +
Sbjct: 766 SGKKDE-----GGGGSSSQDHGGRK--HKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDE 818
Query: 279 STENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSE 338
+++++S P + S+ + +EDS S+ S++ SS S + SS ++S
Sbjct: 819 DSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDAS- 877
Query: 339 SQEEVVSESRGDNPDPTTSYVED--QEDSDSSEEDSSHTLSHSKSESREEQADSESSESL 396
S + S R + D + Y + + S + D S S R + + S+ SL
Sbjct: 878 SDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSL 937
Query: 397 NFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESK 456
+ S+ S S+ +S SSS + S + S SRS S ++
Sbjct: 938 SCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTR 997
Query: 457 SSSEEDGQLK 466
S S+ G K
Sbjct: 998 SPSQRSGSRK 1007
Score = 62.8 bits (151), Expect = 7e-10
Identities = 87/392 (22%), Positives = 144/392 (36%), Gaps = 31/392 (7%)
Query: 119 GSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSK------PEGGDSTQESE 172
G+++ D I +S + QG D + ++S+E+ E V S P G +
Sbjct: 588 GTEKPKD--IGSSSKDHLQGLDPGEP--NKSKEVGGEKIVRSSGGRMDAPASGSACSGLN 643
Query: 173 SEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQ 232
+E GGS G + G L + +S +S R ++ S+ K K + E+
Sbjct: 644 KQEP---GGSHGSETEDTGRSLPSKKERSG--KSHRHKKKKKHKKSSKHKRKHKADTEEK 698
Query: 233 ANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDN---------NTMEEVKSDSTENS 283
++ +SG ++ KS + +R + + DS S
Sbjct: 699 SSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRS 758
Query: 284 NSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEV 343
+ G S + + G S S ++ + + PSS + S +S SQ
Sbjct: 759 LPAEEGSSGKKDEGGGGS---SSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSS 815
Query: 344 VSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESRE-EQADSESSESLNFSEES 402
E D + S+ EE+ S + HS+S SR + S S ++S S
Sbjct: 816 GDEDSDDASSHRLHQKSPSQYSEEEEEEDSGS-EHSRSRSRSGRRHSSHRSSRRSYSSSS 874
Query: 403 PESPEDENSSSQEGLQSHSSSAESQSEESHSEED-DSDSQDSSRSKEDSNSTESKSSSEE 461
S + S Q S S S HS+ DSD D + SK S SSS++
Sbjct: 875 DASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRS-KRHKYSSSDD 933
Query: 462 DGQLKNIEIESRKLTVDAYHNKPIGDQDDNDC 493
D L + SR + ++ G + C
Sbjct: 934 DYSLSCSQSRSRSRSHTRERSRSRGRSRSSSC 965
Score = 50.4 bits (119), Expect = 4e-06
Identities = 80/375 (21%), Positives = 135/375 (36%), Gaps = 43/375 (11%)
Query: 90 EDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSES 149
+DDS + ++ G KD EGG GS + E P T S
Sbjct: 751 QDDSQRRSLPAEEGSSGKKD--EGGG---GSSSQDHGGRKHKGELPPSSCQRRAGTKRSS 805
Query: 150 RELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRS 209
R S+P GD + S S + + E +D G + S
Sbjct: 806 RSSHR-----SQPSSGDEDSDDASSHRL---HQKSPSQYSEEEEEEDSGSEHSRSRSRSG 857
Query: 210 ERGNSRMNSAGMKSKESGENSEQA------NTQDSGGSQLLEHPSRKIFRKSRISEEDD- 262
R +S +S S S +S+Q+ + D S + SR+ ++S S++ D
Sbjct: 858 RRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDR-SRRHSKRSHDSDDSDY 916
Query: 263 -----RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDS-KENLSQEESQN 316
RS+ ++ ++ S S S SR ++ R S+G S+ S + S+ S++
Sbjct: 917 ASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSRS 976
Query: 317 VDGPSSESSQEANLSSQENSSESQEEVVSESRG---DNPDPTTSYVEDQEDSDSSEEDSS 373
S + S+ + ++ + S R ++P+ S D S S
Sbjct: 977 TTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGHESPEERHSGRRDFIRSKIYRSQSP 1036
Query: 374 HTLSHSKSESREEQADSESSES-------------LNFSEESPESPEDENSSSQEGLQSH 420
H + E ++ D +S E SPED+NS + + L
Sbjct: 1037 HYFRSGRGEGPGKKDDGRGDDSKATGPPSQNSNIGTGRGSEGDCSPEDKNSVTAKLLLEK 1096
Query: 421 SSSAESQSEESHSEE 435
S + + + S SEE
Sbjct: 1097 IQSRKVERKPSVSEE 1111
Score = 38.5 bits (88), Expect = 0.014
Identities = 65/320 (20%), Positives = 110/320 (34%), Gaps = 38/320 (11%)
Query: 163 EGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMK 222
EGG E + +E G+ +S G GSE + I + G ++ +
Sbjct: 226 EGG----EDDKDESATNSGTGATASCGLGSEFSTDKGGPFTAVQITNTTGLAQAPGLASQ 281
Query: 223 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 282
G + G S +K+ + E S D+ + + +
Sbjct: 282 GISFGIKNNLGTPLQKLGV------SFSFAKKAPVKLESIASVFKDHAEEGTSEDGTKPD 335
Query: 283 SNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 342
S D GL Q DS G S D K+ E+ Q+ +S S+ + +E + ++ E
Sbjct: 336 EKSSDQGL-QKVGDSDGSSNLDGKKE--DEDPQDGGSLASTLSKLKRMKREEGAGATEPE 392
Query: 343 V--------------------VSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSE 382
+ S + D TT E S + + S+
Sbjct: 393 YYHYIPPAHCKVKPNFPFLLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQ 452
Query: 383 SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE-DDSDSQ 441
E+ S + S P P S E ++ QS ESHS++ ++
Sbjct: 453 GAEKTVSEVSEQPKETSMTEPSEP----GSKAEAKKALGGDVSDQSLESHSQKVSETQMC 508
Query: 442 DSSRSKEDSNSTESKSSSEE 461
+S+ SKE S +T + S+E
Sbjct: 509 ESNSSKETSLATPAGKESQE 528
Score = 35.4 bits (80), Expect = 0.12
Identities = 71/331 (21%), Positives = 118/331 (35%), Gaps = 49/331 (14%)
Query: 132 EESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDG 191
E A +D A++ TSE +KP+ S Q + G SDG SS+ DG
Sbjct: 313 ESIASVFKDHAEEGTSED---------GTKPDEKSSDQGLQKV-----GDSDG-SSNLDG 357
Query: 192 SELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKI 251
+ D++ S S+ MK +E +E + P+
Sbjct: 358 KKEDEDPQDGGSLASTLSKLKR-------MKREEGAGATEPEYYHYIPPAHCKVKPNFPF 410
Query: 252 FRKSRISEE-DDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLS 310
R SE+ D + N E K S + + SQ + + E KE
Sbjct: 411 LLFMRASEQMDGDNTTHPKNAPESKKGSSPKPKSCIKAAASQGAEKTVSEVSEQPKETSM 470
Query: 311 QEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYV-----EDQE-- 363
E S+ ++ + ++S Q S SQ+ ++ N TS E QE
Sbjct: 471 TEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCESNSSKETSLATPAGKESQEGP 530
Query: 364 -------------DSDSSEEDSSHTLSHSKSESREEQA------DSESSESLNFSEESPE 404
D ++ + S L +K+E + D + S + + + E
Sbjct: 531 KHPTGPFFPVLSKDESTALQWPSELLIFTKAEPSISYSCNPLYFDFKLSRNKDARTKGTE 590
Query: 405 SPEDENSSSQEGLQSHSSSAESQSEESHSEE 435
P+D SSS++ LQ ++S+E E+
Sbjct: 591 KPKDIGSSSKDHLQGLDPGEPNKSKEVGGEK 621
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 70.1 bits (170), Expect = 4e-12
Identities = 91/395 (23%), Positives = 155/395 (39%), Gaps = 53/395 (13%)
Query: 145 TTSESRELDNEDRVDSKPEGGDSTQESE-----SEEHWVGGGSD--GESSHGDGS----- 192
T S SR D R ++ P Q ++ S E W+ G E S
Sbjct: 343 TPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVK 402
Query: 193 --ELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSR- 249
++ D S+ P + + + + K ++ NSE+ + + + + SR
Sbjct: 403 ERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRS 462
Query: 250 KIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDS--KE 307
K KS+ E D + ++ M +S ++ N ++ + + DSKG QE S KE
Sbjct: 463 KSKEKSKSKERDSKHNRNEEKRMRS-RSKGRDHENVKE---KEKQSDSKGKDQERSRSKE 518
Query: 308 NLSQEESQNVDGPSSES----------SQEANLSSQENSSESQEEVVSESRGDNPDPTTS 357
Q ES++ + S+S S+E +++ ++S S+ S SR D S
Sbjct: 519 KSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSR-DRSRRVRS 577
Query: 358 YVEDQEDSDSSE-----EDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSS 412
D++ S S E E S+S R S+ S E E S
Sbjct: 578 RTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQ 637
Query: 413 S--------QEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSK----EDSNSTESKSSSE 460
S QE SH + +S+ D +S ++SR K + S ++ K SS+
Sbjct: 638 SRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQ 697
Query: 461 ED----GQLKNIEIESRKLTVDAYHNKPIGDQDDN 491
++ LKN E E + +V+ + K G ++D+
Sbjct: 698 DNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDH 732
Score = 61.6 bits (148), Expect = 2e-09
Identities = 72/373 (19%), Positives = 144/373 (38%), Gaps = 39/373 (10%)
Query: 116 SRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEE 175
S++ +E +S S+ DS+ D+ S S D+E + K + S +
Sbjct: 181 SKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRK 240
Query: 176 HWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSE-------------RGNSRMNSAGMK 222
H +S SE + E +++ ++R E + + + K
Sbjct: 241 HKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERK 300
Query: 223 SKESGENSEQANTQDSGGSQ-----LLEHPSRKIF-RKSRISEEDDRSELDDNNTMEEVK 276
++E E + N +S + L+ RKI R R RS D E
Sbjct: 301 NRER-ERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETP 359
Query: 277 SD-STENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQEN 335
E ++ +S R KGD E ++ + + + V + + N+S N
Sbjct: 360 PHWRQEMQRAQRMRVSSGERWIKGDKSELNE--IKENQRSPVRVKERKITDHRNVSESPN 417
Query: 336 SSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSES 395
+E+ V + + ++ + + + +S+ ++ + +KS+SR + + S+
Sbjct: 418 RKNEKEKKVKDHKSNSKER-----DIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK- 471
Query: 396 LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDS--SRSKEDSNST 453
E N + ++ ++S S + ++ + ++ DS +D SRSKE S
Sbjct: 472 --------ERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQL 523
Query: 454 ESKSSSEEDGQLK 466
ESKS+ + + K
Sbjct: 524 ESKSNEHDHSKSK 536
Score = 60.5 bits (145), Expect = 4e-09
Identities = 73/361 (20%), Positives = 146/361 (40%), Gaps = 40/361 (11%)
Query: 102 DSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNED-RVDS 160
D K+R NS + +A +S + ++ ++ +S+ NE+ R+ S
Sbjct: 428 DHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRS 487
Query: 161 KPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAG 220
+ +G D E E+ G D E S E ++ S E+ + +
Sbjct: 488 RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSR 547
Query: 221 MKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEED-DRSELDDNNTMEEVKSDS 279
G++S + T++ S+ SR++ +SR + D RS+ +E +
Sbjct: 548 ECDITKGKHSYNSRTRERSRSR---DRSRRV--RSRTHDRDRSRSKEYHRYREQEYRRRG 602
Query: 280 TENSNSRDTGLSQPRRDSKGDSQEDSKENLSQE-ESQNVDGPSSESSQEANLSSQENSSE 338
S R T + R + + DS+ + +E +S+N D +QE+ S ++ +SE
Sbjct: 603 RSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKD---KYRNQESKSSHRKENSE 659
Query: 339 SQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNF 398
S++ + S+SR N S + SRE++AD + S
Sbjct: 660 SEKRMYSKSRDHN---------------------------SSNNSREKKADRDQSPFSKI 692
Query: 399 SEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSN--STESK 456
+ S ++ + + + SS E ++++S +E+D + + + +S+ + E K
Sbjct: 693 KQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752
Query: 457 S 457
S
Sbjct: 753 S 753
Score = 44.7 bits (104), Expect = 2e-04
Identities = 66/307 (21%), Positives = 105/307 (34%), Gaps = 49/307 (15%)
Query: 77 RSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSR-------LGSDEDSDDTIQ 129
RS KG D ++ E + D+ G D K++ + S+ ++D +
Sbjct: 486 RSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSR 545
Query: 130 ASEESAPQGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH 188
+ E +G+ S T E SR D RV S+ D ++ E +
Sbjct: 546 SRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRY------------ 593
Query: 189 GDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPS 248
E RG SR S + +DS S+ E S
Sbjct: 594 ---------------REQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQS 638
Query: 249 RKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKEN 308
R K + ++ +S ++ E +S+ S SRD S R+ K D +
Sbjct: 639 R---NKDKYRNQESKS----SHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSK 691
Query: 309 LSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVE--DQEDSD 366
+ Q N +SS N E S E+ +S+G D + D E S
Sbjct: 692 IKQSSQDN----ELKSSMLKN-KEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSP 746
Query: 367 SSEEDSS 373
++ED S
Sbjct: 747 GTDEDKS 753
Score = 39.3 bits (90), Expect = 0.008
Identities = 26/93 (27%), Positives = 44/93 (47%), Gaps = 6/93 (6%)
Query: 380 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD 439
KS+ ++E+ S S S S D +SSS S SS +ES +EE +
Sbjct: 180 KSKVKKEEKKRHKSSS-----SSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKH 234
Query: 440 SQDSSR-SKEDSNSTESKSSSEEDGQLKNIEIE 471
++S + KE +SK S+ + + +N+E +
Sbjct: 235 RKNSRKHKKEKKKRKKSKKSASSESEAENLEAQ 267
Score = 34.7 bits (78), Expect = 0.21
Identities = 30/141 (21%), Positives = 59/141 (41%), Gaps = 3/141 (2%)
Query: 306 KENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDS 365
K + +EE + SS SS ++ S +S S + SES + + +++S
Sbjct: 180 KSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRK-KKHRKNS 238
Query: 366 DSSEEDSSHTLSHSKSESREEQADS--ESSESLNFSEESPESPEDENSSSQEGLQSHSSS 423
+++ KS S E +A++ +S EE P PE+ + ++
Sbjct: 239 RKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKE 298
Query: 424 AESQSEESHSEEDDSDSQDSS 444
+++ E E + +SQ +S
Sbjct: 299 RKNRERERERECNPPNSQPAS 319
Score = 34.3 bits (77), Expect = 0.27
Identities = 20/79 (25%), Positives = 35/79 (44%)
Query: 396 LNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTES 455
L+ E P+S + + S SSS+ S S+ S + SDS DS + E+ +
Sbjct: 172 LSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRK 231
Query: 456 KSSSEEDGQLKNIEIESRK 474
K + + K + + +K
Sbjct: 232 KKHRKNSRKHKKEKKKRKK 250
Score = 32.7 bits (73), Expect = 0.78
Identities = 64/338 (18%), Positives = 110/338 (32%), Gaps = 71/338 (21%)
Query: 222 KSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTE 281
KSK E ++ + S S + S S+ S + SE ++ K +
Sbjct: 180 KSKVKKEEKKRHKSSSSSSSSSSDSDSSS---DSQSSSDSSDSESATEEKSKKRKKKHRK 236
Query: 282 NSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNV------------------------ 317
NS + ++ K S E ENL + V
Sbjct: 237 NSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADE 296
Query: 318 ---DGPSSESSQEANLSSQENSSESQEEVVSES----RGDNPDPTTSYVEDQEDSDSSEE 370
E +E N + + +S + +V+ S +G P Y
Sbjct: 297 KERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGP---RRYRTPSRSRSRDRF 353
Query: 371 DSSHTLSHSKSESREEQ------------ADSESSESLNFSEESP--------------- 403
S T H + E + Q D + ++ SP
Sbjct: 354 RRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVS 413
Query: 404 ESPEDENSSSQEGLQSHSSSAESQSEESHSEEDD---SDSQDSSRSKEDSNSTESKSSSE 460
ESP +N ++ ++ H S+++ + +SE+DD + + ++SK S S E S E
Sbjct: 414 ESPNRKNEKEKK-VKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKE 472
Query: 461 EDGQLKNIE---IESRKLTVDAYHNKPIGDQDDNDCQD 495
D + E + SR D + K Q D+ +D
Sbjct: 473 RDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKD 510
>gi|4504487 histidine rich calcium binding protein precursor [Homo
sapiens]
Length = 699
Score = 69.7 bits (169), Expect = 6e-12
Identities = 92/471 (19%), Positives = 160/471 (33%), Gaps = 74/471 (15%)
Query: 26 ESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDD 85
E E+ EE + A A+ ++ +E + H + G R G DD
Sbjct: 193 EEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHH-----GPSHRHQGHEEDD 247
Query: 86 KDDDEDDSGDDTFG-------------------DDDSGPGPKDRQEGGNSRLGSDEDSDD 126
DDD+DD DD D+D G R R ++D+DD
Sbjct: 248 DDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEEDDNDD 307
Query: 127 TIQASE--ESAPQGQDSAQDTTS--------------ESRELDNEDRVDSKPEG------ 164
++E A + QD ++ D E+ D E
Sbjct: 308 DDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQ 367
Query: 165 ----GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESI-----------RS 209
G +E E EE V G S G + D+E Q + +
Sbjct: 368 HVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREED 427
Query: 210 ERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDN 269
E ++ + ++S ++ E + Q ++ HP K DRS L +
Sbjct: 428 EEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVK-------DRSHLRKD 480
Query: 270 NTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEAN 329
++ EE + + S+ D S+ D ++ +EE + E +E
Sbjct: 481 DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK 540
Query: 330 LSSQENSSESQEEVVSESRGD-NPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQA 388
+E E + E +E +PD + E++E+ + EED R E+A
Sbjct: 541 EEEEEEEDEERREERAEVGAPLSPDHSE---EEEEEEEGLEEDEPRFTIIPNPLDRREEA 597
Query: 389 DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAE--SQSEESHSEEDD 437
SSE + + P+ ++ + L + S ++ E H +E++
Sbjct: 598 GGASSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEEN 648
Score = 68.9 bits (167), Expect = 1e-11
Identities = 116/558 (20%), Positives = 188/558 (33%), Gaps = 131/558 (23%)
Query: 28 EDSEEWKGHLAQAPTPPLANEDPS-----------DSTQSEEGLGSDDHQYIYRLAGGFS 76
E S E + HL P N+D S D + +E + + Y + L G S
Sbjct: 52 EASAELRHHLHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKE---YGHLLPGHRS 108
Query: 77 RSTGKGGDDKDDDEDDSGDDTFGDDDS------GPGPKDRQEGGNSR---------LGSD 121
+ D K DE SG++ F + G G +D ++ R D
Sbjct: 109 Q------DHKVGDEGVSGEEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQD 162
Query: 122 EDSDDTIQASEES-----APQGQDSAQDTTSESRELDNEDRVDSKPEG---------GDS 167
ED D+ + + +G D D E E + E+ S G G
Sbjct: 163 EDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSE 222
Query: 168 TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESG 227
E S+ H G S H + + DD+ DD + + E + G +E
Sbjct: 223 EDEDVSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDE 282
Query: 228 ENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELD------------DNNTMEEV 275
+ S+ + +D PS + R EEDD + D ++ EEV
Sbjct: 283 DVSDGHHHRD---------PSHR----HRSHEEDDNDDDDVSTEYGHQAHRHQDHRKEEV 329
Query: 276 KSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQ-- 333
++ S E+ + Q RD + D ++ S E Q G E +E ++ Q
Sbjct: 330 EAVSGEHHHHVPDHRHQGHRDEEED-EDVSTERWHQGPQHVHHGLVDEEEEEEEITVQFG 388
Query: 334 --------ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEE----DSSHTLSHSKS 381
+E+ E + + P V +ED + S E SH SH
Sbjct: 389 HYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQAPSHRQSHQDE 448
Query: 382 ESREEQADS----------------------ESSESLNFSEESPESPEDENSSSQEGLQS 419
E+ Q S + SE EE P S E+++ SS++G +
Sbjct: 449 ETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKG 508
Query: 420 --HSS------------------SAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSS 459
H S E + E+ EE++ D + E S
Sbjct: 509 THHGSRDQEDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSE 568
Query: 460 EEDGQLKNIEIESRKLTV 477
EE+ + + +E + + T+
Sbjct: 569 EEEEEEEGLEEDEPRFTI 586
Score = 68.9 bits (167), Expect = 1e-11
Identities = 101/490 (20%), Positives = 176/490 (35%), Gaps = 70/490 (14%)
Query: 24 NNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGG 83
+ ++EDS E + HL + +ED +E + S+ H +I R G G
Sbjct: 139 SEDTEDSAEHRHHLPSHRSHSHQDED------EDEVVSSEHHHHILR--------HGHRG 184
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAP----QGQ 139
D +DDE + ++ +++ Q + GS+ED +D P QG
Sbjct: 185 HDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEED-EDVSDGHHHHGPSHRHQGH 243
Query: 140 DSAQDTTSESRELDNEDRVDSKPEGGDSTQES---ESEEHWVGGGSDGESSHGDGSELDD 196
+ D + + D++D V + + E +E G + SH S +D
Sbjct: 244 EEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSHEED 303
Query: 197 EGMQSDDPESIRSERGNSRMNSAGMKSKE----SGENSEQA----------NTQDSGGSQ 242
+ +D + + +E G+ + +E SGE+ +D S
Sbjct: 304 D----NDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVST 359
Query: 243 LLEHPSRKIFRKSRISEEDDRSELD-------DNNTMEEVKSDSTENSNSRDTGLSQPR- 294
H + + EE++ E+ ++ KSD + + T +
Sbjct: 360 ERWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHH 419
Query: 295 -RDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV----SESRG 349
R + + +E S E Q S E+ S +E S V S R
Sbjct: 420 HRVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRK 479
Query: 350 DNPDPTTSYVED----QEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPES 405
D+ + ED +ED +SSE+ T S+ + EE + SLN EE E
Sbjct: 480 DDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEED 539
Query: 406 PEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD----SQDSSR---------SKEDSNS 452
E+E E + + + HSEE++ + +D R +E++
Sbjct: 540 KEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGG 599
Query: 453 TESKSSSEED 462
S+ S ED
Sbjct: 600 ASSEEESGED 609
Score = 48.9 bits (115), Expect = 1e-05
Identities = 55/245 (22%), Positives = 91/245 (37%), Gaps = 45/245 (18%)
Query: 273 EEVKSDSTENSNSRDTGLSQPRRDSK----------GDSQEDSK---ENLSQEESQNVDG 319
+E K STEN + + + + D G +D K E +S EE G
Sbjct: 69 DENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSGEEVFAEHG 128
Query: 320 PSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHS 379
+ + E+S+E + + S + S+ ++ ED S E H L H
Sbjct: 129 GQARGHRGHGSEDTEDSAEHRHHLPSHR-------SHSHQDEDEDEVVSSEHHHHILRHG 181
Query: 380 KSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSD 439
E + E EE E E+E +S++ G Q+H H E+D D
Sbjct: 182 HRGHDGEDDEGE--------EEEEEEEEEEEASTEYGHQAHR-------HRGHGSEEDED 226
Query: 440 SQD-------SSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDND 492
D S R + + ++D ++ IE R A+ ++ G ++D D
Sbjct: 227 VSDGHHHHGPSHRHQGHEEDDDDDDDDDDDDDDDDVSIEYRH---QAHRHQGHGIEEDED 283
Query: 493 CQDGY 497
DG+
Sbjct: 284 VSDGH 288
Score = 39.3 bits (90), Expect = 0.008
Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 13/98 (13%)
Query: 23 QNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKG 82
+ E E+ EE + A+ P L+ + + + EEGL D+ ++ + R G
Sbjct: 541 EEEEEEEDEERREERAEVGAP-LSPDHSEEEEEEEEGLEEDEPRFTI-IPNPLDRREEAG 598
Query: 83 GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGS 120
G E++SG+DT GP+D QE GN + GS
Sbjct: 599 G---ASSEEESGEDT--------GPQDAQEYGNYQPGS 625
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 69.3 bits (168), Expect = 8e-12
Identities = 83/387 (21%), Positives = 159/387 (41%), Gaps = 41/387 (10%)
Query: 119 GSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRV-------DSKPEGGDSTQES 171
G+ +SD + +A E+ + ++D T+ S DN + ++K G + E
Sbjct: 4 GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63
Query: 172 ESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSE 231
E G + G +EL E D+ + + ++ KE GE E
Sbjct: 64 PPTES--GKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEE 121
Query: 232 QA-NTQDSGG--SQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDT 288
+Q+ G + P ++S ++ E ++E +E K +S + +++ D
Sbjct: 122 TTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAE------EKEAKPESGQKADANDR 175
Query: 289 GLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSES- 347
+P K +E+ + SQEE+ S+E ++A + +E +ESQ+ VV +
Sbjct: 176 DKPEP----KATVEEEDAKTASQEETGQRKECSTEPKEKA--TDEEAKAESQKAVVEDEA 229
Query: 348 -----RGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESL----NF 398
D + +++ D+ ED+ S SE +E+ + E +
Sbjct: 230 KAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSS 289
Query: 399 SEESPESPEDE-NSSSQEGL----QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNST 453
EE PESP E ++ S +GL + ++ S SE S S+ S + S ++ +
Sbjct: 290 PEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAP 349
Query: 454 ESKSSSEEDGQLKNIEIESRKLTVDAY 480
E + S+ + + ++RK VD +
Sbjct: 350 ERRVSA--PARPRGPRAQNRKAIVDKF 374
Score = 53.9 bits (128), Expect = 3e-07
Identities = 84/414 (20%), Positives = 159/414 (38%), Gaps = 49/414 (11%)
Query: 88 DDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTS 147
D+ + SG ++ G K EG + G +E AP + +
Sbjct: 38 DNPEMSGGGAPAEETKGTAGKAINEGPPTESGK-----------QEKAPAEDGMSAELQG 86
Query: 148 ESRELDNEDRVDSKPEGGDST--------QESESEEHWVGGGSDGESSHGDGSELDDEGM 199
E+ LD E +V+S+ E G ++ E EE VG + G E E
Sbjct: 87 EANGLD-EVKVESQREAGGKEDAEAELKKEDGEKEETTVGS----QEMTGRKEETKSEPK 141
Query: 200 QSDDPES-IRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRIS 258
++++ ES + SE+ + A ESG+ ++ + +E K +
Sbjct: 142 EAEEKESTLASEKQKAEEKEA---KPESGQKADANDRDKPEPKATVEEEDAKTASQEETG 198
Query: 259 EEDDRS-ELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNV 317
+ + S E + T EE K++S + + D ++P+ D +E++K +E
Sbjct: 199 QRKECSTEPKEKATDEEAKAES-QKAVVEDEAKAEPKEP---DGKEEAKHGAKEEAD--- 251
Query: 318 DGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLS 377
+ E +++A + + SE QE+ V + S E+ +S + E H LS
Sbjct: 252 ---AKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGE---GHNLS 305
Query: 378 HSK------SESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEES 431
+ + + SESS S + + PESP + + S+ A + +
Sbjct: 306 TDGLGPDCVASGQTSPSASESSPS-DVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRA 364
Query: 432 HSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPI 485
+ + D + S + +K++ G +KN+ +E + Y + I
Sbjct: 365 QNRKAIVDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTKKYEHVDI 418
Score = 37.7 bits (86), Expect = 0.024
Identities = 37/202 (18%), Positives = 77/202 (38%), Gaps = 13/202 (6%)
Query: 293 PRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNP 352
P + D +++E + Q+E + + ++ S N + ++E + + N
Sbjct: 3 PGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINE 62
Query: 353 DPTTSYVEDQ----EDSDSSE-EDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE 407
P T + + ED S+E + ++ L K ES+ E E +E+ E+ +
Sbjct: 63 GPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEET 122
Query: 408 DENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKN 467
S G + + S ++EE S + K+ + E+K S + +
Sbjct: 123 TVGSQEMTGRKEETKSEPKEAEEKEST--------LASEKQKAEEKEAKPESGQKADAND 174
Query: 468 IEIESRKLTVDAYHNKPIGDQD 489
+ K TV+ K ++
Sbjct: 175 RDKPEPKATVEEEDAKTASQEE 196
Score = 37.0 bits (84), Expect = 0.041
Identities = 36/180 (20%), Positives = 72/180 (40%), Gaps = 19/180 (10%)
Query: 85 DKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQD 144
++ + + +SG +D P PK E +++ S E++ + S E + D
Sbjct: 158 EEKEAKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAK 217
Query: 145 TTSESRELDNEDRVDSK-PEGGDSTQESESEEHWVGGGSDG--ESSHGDGSELDDEGMQS 201
S+ +++E + + K P+G + + EE ++ E+ G SE ++ ++
Sbjct: 218 AESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEK 277
Query: 202 DD--------------PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHP 247
+ PES E N + G SG+ S A+ +S S + + P
Sbjct: 278 EPEGGAGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSAS--ESSPSDVPQSP 335
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 68.6 bits (166), Expect = 1e-11
Identities = 62/228 (27%), Positives = 95/228 (41%), Gaps = 27/228 (11%)
Query: 223 SKESGENSEQANTQDSGGSQLLEHPSRKIFRK--SRISEEDDRSELDDNNTMEEVKSDST 280
+K G +A SG L PS K+ RK S ISE + + EE + D
Sbjct: 867 AKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPE 926
Query: 281 ENSNSRDTG---LSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSS 337
+ + + G P+RD +E K +S +D E+SQE++ E
Sbjct: 927 QEKEAGEPGRPGTKPPKRD-----EERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDD 981
Query: 338 ESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQ-ADSESSESL 396
E EE E R + D T E + D + SS ++ S+ + +DSESS S
Sbjct: 982 EEDEE--DEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSS- 1038
Query: 397 NFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSS 444
+SSS S SSS+ S S ES SE+++ + + ++
Sbjct: 1039 -------------SSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAA 1073
Score = 54.3 bits (129), Expect = 3e-07
Identities = 46/169 (27%), Positives = 68/169 (40%), Gaps = 12/169 (7%)
Query: 300 DSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDP-TTSY 358
++ E+ + S ++ D P E +EA + + + + E RG S+
Sbjct: 905 EASEEKRPRPSTPAEEDEDDPEQE--KEAGEPGRPGTKPPKRD---EERGKTQGKHRKSF 959
Query: 359 VEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQ 418
D E ++S+E SS E EE D E + E EDE S S
Sbjct: 960 ALDSEGEEASQESSSEK-DEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCS 1018
Query: 419 SHSSS-----AESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEED 462
++ S + S SE S S S S SS S S+S+ES S EE+
Sbjct: 1019 LYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEE 1067
Score = 50.1 bits (118), Expect = 5e-06
Identities = 39/175 (22%), Positives = 66/175 (37%), Gaps = 26/175 (14%)
Query: 330 LSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQA- 388
L S + + E+ S P P+T ED++D + +E +K R+E+
Sbjct: 890 LPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERG 949
Query: 389 ------------DSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEED 436
DSE E+ S + +DE E + + + ++E S E++
Sbjct: 950 KTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDE 1009
Query: 437 DSDSQ-------------DSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVD 478
+SDS DS+ E S+S+ S SSS + S + D
Sbjct: 1010 ESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSED 1064
Score = 47.4 bits (111), Expect = 3e-05
Identities = 46/178 (25%), Positives = 69/178 (38%), Gaps = 10/178 (5%)
Query: 166 DSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKE 225
+ ++ SE+ E S D E + E + P + +R R + G K
Sbjct: 899 EPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKS 958
Query: 226 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTME-EVKSDSTENSN 284
+SE S+ E + E++DR E D E EV E S+
Sbjct: 959 FALDSEGEEASQESSSEKDEEDDEED------EEDEDREEAVDTTKKETEVSDGEDEESD 1012
Query: 285 SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEE 342
S D + DS DS+ + S S + SS SS ++ SS E+SSE +EE
Sbjct: 1013 SSSKCSLYADSDGENDSTSDSESSSSSSSSSS---SSSSSSSSSSSSSSESSSEDEEE 1067
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/189 (22%), Positives = 70/189 (37%), Gaps = 8/189 (4%)
Query: 12 GLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEGLGSDDHQYIYRL 71
GL AL + ++ E SE + + P P E+ D + E+ G
Sbjct: 883 GLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEKEAGEPGRPGTKPP 942
Query: 72 AGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQAS 131
R +G K D G++ + S +D +E DED ++ + +
Sbjct: 943 KRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEE-----DEDREEAVDTT 997
Query: 132 --EESAPQGQDSAQDTTSE-SRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSH 188
E G+D D++S+ S D++ DS + S+ S S S SS
Sbjct: 998 KKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSS 1057
Query: 189 GDGSELDDE 197
+ S D+E
Sbjct: 1058 SESSSEDEE 1066
Score = 44.3 bits (103), Expect = 3e-04
Identities = 40/162 (24%), Positives = 69/162 (42%), Gaps = 25/162 (15%)
Query: 84 DDKDDDEDDSGDDTFGDDDSGPGPKDRQEG---GNSRLGSDEDSDDTIQASEESAPQGQD 140
+D+DD E + G + P +D + G G R DS+ +AS+ES+ + +
Sbjct: 920 EDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGE-EASQESSSEKDE 978
Query: 141 SAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSE-----LD 195
+D + + D E+ VD T + E+E SDGE D S D
Sbjct: 979 --EDDEEDEEDEDREEAVD--------TTKKETEV------SDGEDEESDSSSKCSLYAD 1022
Query: 196 DEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQD 237
+G +S S +S +S+ S S +S +++++D
Sbjct: 1023 SDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSED 1064
Score = 33.5 bits (75), Expect = 0.46
Identities = 30/122 (24%), Positives = 52/122 (42%), Gaps = 7/122 (5%)
Query: 339 SQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNF 398
SQ+ S SR D P + + S + + +T S + ++ A S S+ S +F
Sbjct: 244 SQDTSFSSSRQDTPSSFGQF------TPQSSQGTPYT-SRGSTPYSQDSAYSSSTTSTSF 296
Query: 399 SEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSS 458
E+ + S + S +S+ S + + + S S SS S+S+ S SS
Sbjct: 297 KPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAATASSSASSSSLSSSSSSSSSSSS 356
Query: 459 SE 460
S+
Sbjct: 357 SQ 358
Score = 31.2 bits (69), Expect = 2.3
Identities = 30/121 (24%), Positives = 51/121 (42%), Gaps = 13/121 (10%)
Query: 354 PTTSYVEDQEDSDSSEEDSSHT--LSHSKSESREEQA--DSESSESLNFSEESP------ 403
P VED E +++S+E LSH E A + + +L E P
Sbjct: 1269 PALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEPVPAPAALF 1328
Query: 404 ESPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDG 463
SP DE + E + + + + Q + EE + + ++ +E+ +S SSS DG
Sbjct: 1329 SSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSD---SSSSSDG 1385
Query: 464 Q 464
+
Sbjct: 1386 E 1386
Score = 29.3 bits (64), Expect = 8.7
Identities = 32/165 (19%), Positives = 64/165 (38%), Gaps = 7/165 (4%)
Query: 288 TGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSS-QENSSESQEEVVSE 346
+G + +S+ S D+ + + G + SQ+ + SS ++++ S + +
Sbjct: 207 SGAATETAESRRRSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQ 266
Query: 347 SRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESP 406
S P + +DS S +S + +SE+ + A S S + + + +
Sbjct: 267 SSQGTPYTSRGSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTA 326
Query: 407 EDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSN 451
+++ + SSS S S S S S S D+N
Sbjct: 327 IAATTAATASSSASSSSLSSSSSSS------SSSSSSQFRSSDAN 365
>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
Length = 709
Score = 67.4 bits (163), Expect = 3e-11
Identities = 76/367 (20%), Positives = 146/367 (39%), Gaps = 41/367 (11%)
Query: 140 DSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGM 199
DS ++ E LD D + PE D ESE+ + + GS+ + M
Sbjct: 4 DSREEKDGELNVLD--DILTEVPEQDDELYNPESEQ---------DKNEKKGSKRKSDRM 52
Query: 200 QSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISE 259
+S D + + + ++ S + S S N +T+ ++ ++ R R+ +
Sbjct: 53 ESTDTKRQKPSVHSRQLVSKPLSSSVSN-NKRIVSTKGKSATEYKNEEYQRSERNKRL-D 110
Query: 260 EDDRSELDDNNTMEEVKSDSTENS-NSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVD 318
D + L + + E K+ + RD P R +K + D E + E +
Sbjct: 111 ADRKIRLSSSASREPYKNQPEKTCVRKRD-----PERRAKSPTP-DGSERIGLEVDRRAS 164
Query: 319 GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSH 378
S S +E N + E+ S+ +G+N + VE+ + D E+ +
Sbjct: 165 RSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDEE 224
Query: 379 SKSESREEQADSESSESLNFSEESPESPEDENSSSQEG--LQSHSSSAESQSE------- 429
+ EE+ + E E EE E +DE +EG + S +++S SE
Sbjct: 225 VDEDGEEEEEEEEEEEE-EEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSESVSFTDG 283
Query: 430 --ESHSEEDDSDSQDSSRSK---------EDSNSTESKSSSEEDGQLKNIEIESRKLTVD 478
S S D SD + R + + S S+ S+S +++ +LK + ++R +
Sbjct: 284 SVRSGSGTDGSDEKKKERKRARGISPIVFDRSGSSASESYADQTSKLKYVLQDARFFLIK 343
Query: 479 AYHNKPI 485
+ +++ +
Sbjct: 344 SNNHENV 350
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/172 (24%), Positives = 70/172 (40%), Gaps = 16/172 (9%)
Query: 76 SRSTGKGGDDKDDDEDDSGDDTFGD---DDSGPGPKDRQEGGNSRLGSDEDSDDTIQASE 132
SRS+ ++ + +E S +T D+ G ++ +EG + DE+ ++ + E
Sbjct: 164 SRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEEDAEEDE 223
Query: 133 ESAPQGQDSAQDTTSESRELDNE------DRVDSKPEGGDSTQESESEEHWVGGGSDGES 186
E G++ ++ E E + E D D K EG D SE+ + GS+
Sbjct: 224 EVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASD----SGSE-SV 278
Query: 187 SHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDS 238
S DGS G D + + ER +R S + + SE Q S
Sbjct: 279 SFTDGSVRSGSGTDGSDEK--KKERKRARGISPIVFDRSGSSASESYADQTS 328
Score = 39.3 bits (90), Expect = 0.008
Identities = 53/253 (20%), Positives = 104/253 (41%), Gaps = 25/253 (9%)
Query: 255 SRISEEDDR-----SELDDNNTM-EEVKSDSTENSNSRDTG--------LSQPRRDSKGD 300
+ + E+DD SE D N + KSD E+++++ +S+P S +
Sbjct: 21 TEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSN 80
Query: 301 SQED-SKENLSQEESQNVDGPSSESSQ--EANLSSQENSSESQEEVVSESRGDNPDPTTS 357
++ S + S E +N + SE ++ +A+ + +SS S+E ++ P+ T
Sbjct: 81 NKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQ-----PEKTCV 135
Query: 358 YVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGL 417
D E S + + R ++ S E +N E + + SS E
Sbjct: 136 RKRDPERRAKSPTPDGSERIGLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDE-- 193
Query: 418 QSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTV 477
Q +++ E + E EED+ + ++ + E+ + + EE+ + + E E +
Sbjct: 194 QGNNTENEEEGVEEDVEEDE-EVEEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQ 252
Query: 478 DAYHNKPIGDQDD 490
D K G+ D
Sbjct: 253 DERDQKEEGNDYD 265
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 67.0 bits (162), Expect = 4e-11
Identities = 69/298 (23%), Positives = 115/298 (38%), Gaps = 24/298 (8%)
Query: 193 ELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSG-GSQLLEHPSRKI 251
++ +G + + ER SR + + S S + G GS + +
Sbjct: 239 KIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELERE 298
Query: 252 FRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPR-RDSKGDSQEDSKENLS 310
+ R+ E E + + + S SR+ S+ R RD KGD ++ +E
Sbjct: 299 KERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER-- 356
Query: 311 QEESQNVDGPSSESSQEANLSSQ-ENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSE 369
E +N G + + ++ E E E E R + ED++D +
Sbjct: 357 --EKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD 414
Query: 370 E--DSSHTLSHSKSESREEQ-----------ADSESSESLNFSEESPESPEDENSSSQEG 416
+ DS HS+S SRE + S S S+ ES E N S+ G
Sbjct: 415 DKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSG 474
Query: 417 LQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNS---TESKSSSEEDGQLKNIEIE 471
Q + S E + HS + S+ SRSKE S+ ++SK S++ + ++ IE
Sbjct: 475 SQGRTDSVEKSKKREHSPSKEK-SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIE 531
Score = 55.5 bits (132), Expect = 1e-07
Identities = 72/331 (21%), Positives = 123/331 (37%), Gaps = 27/331 (8%)
Query: 108 KDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDS 167
KD +EG E+ D ++ +P+ S + + SR + R D
Sbjct: 242 KDGKEGA-------EEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHH-REGHGSSSFDR 293
Query: 168 TQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKESG 227
E E E + + S D G++ S ER SR S K
Sbjct: 294 ELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRS--RERHRSRSRSRDRKGDRRD 351
Query: 228 ENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRD 287
+ E+ + G + + + K R +E + E + E+ E ++
Sbjct: 352 RDREREKENERGRRR------DRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKE 405
Query: 288 TGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSES 347
+ RD K DS+++ K S+ S+ S S+ A S+ S E + +ES
Sbjct: 406 DKDDRRHRDDKRDSKKEKKH--SRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNES 463
Query: 348 RGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPE 407
+ + + S Q +DS E+ S SK +SR+ E S + S+ +S +
Sbjct: 464 KEKSNKRSRS--GSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521
Query: 408 DENSSSQEGLQSHSSSAESQSEESHSEEDDS 438
+ SQ S ESQ E+ H +D++
Sbjct: 522 HDRRRSQ------SIEQESQ-EKQHKNKDET 545
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.293 0.116 0.305
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,550,997
Number of Sequences: 37866
Number of extensions: 1167206
Number of successful extensions: 26424
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 757
Number of HSP's successfully gapped in prelim test: 1510
Number of HSP's that attempted gapping in prelim test: 6892
Number of HSP's gapped (non-prelim): 10218
length of query: 497
length of database: 18,247,518
effective HSP length: 106
effective length of query: 391
effective length of database: 14,233,722
effective search space: 5565385302
effective search space used: 5565385302
T: 11
A: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 44 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.