Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 121114287

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo
sapiens]
         (1090 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]  2204   0.0  
gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Hom...   951   0.0  
gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo ...   805   0.0  
gi|215820635 protein phosphatase 1, regulatory subunit 13 like [...   296   5e-80
gi|63003907 protein phosphatase 1, regulatory subunit 13 like [H...   296   5e-80
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   86   1e-16
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   86   1e-16
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   86   1e-16
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    86   1e-16
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    84   9e-16
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni...    84   9e-16
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    83   1e-15
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    82   2e-15
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1...    82   3e-15
gi|163965366 nascent polypeptide-associated complex alpha subuni...    82   3e-15
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun...    77   9e-14
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit...    77   9e-14
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni...    77   1e-13
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit...    77   1e-13
gi|150170670 piccolo isoform 2 [Homo sapiens]                          72   3e-12
gi|150378539 piccolo isoform 1 [Homo sapiens]                          72   3e-12
gi|20270347 ankyrin repeat domain 54 [Homo sapiens]                    71   6e-12
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          69   2e-11
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          69   2e-11
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          69   2e-11
gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]       69   3e-11
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              68   5e-11
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             67   9e-11
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ...    67   9e-11
gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]      67   1e-10

>gi|121114287 apoptosis-stimulating protein of p53, 1 [Homo sapiens]
          Length = 1090

 Score = 2204 bits (5710), Expect = 0.0
 Identities = 1090/1090 (100%), Positives = 1090/1090 (100%)

Query: 1    MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDH 60
            MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDH
Sbjct: 1    MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDH 60

Query: 61   MMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVG 120
            MMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVG
Sbjct: 61   MMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGVG 120

Query: 121  NPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLK 180
            NPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLK
Sbjct: 121  NPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLK 180

Query: 181  ERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQ 240
            ERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQ
Sbjct: 181  ERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQ 240

Query: 241  QLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRN 300
            QLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRN
Sbjct: 241  QLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRN 300

Query: 301  MEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPV 360
            MEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPV
Sbjct: 301  MEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPV 360

Query: 361  LGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVK 420
            LGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVK
Sbjct: 361  LGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVK 420

Query: 421  QGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLE 480
            QGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLE
Sbjct: 421  QGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLE 480

Query: 481  RRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPA 540
            RRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPA
Sbjct: 481  RRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPA 540

Query: 541  GDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSA 600
            GDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSA
Sbjct: 541  GDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSA 600

Query: 601  LNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADG 660
            LNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADG
Sbjct: 601  LNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADG 660

Query: 661  STVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGP 720
            STVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGP
Sbjct: 661  STVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGP 720

Query: 721  NIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP 780
            NIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP
Sbjct: 721  NIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP 780

Query: 781  LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEA 840
            LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEA
Sbjct: 781  LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEA 840

Query: 841  PSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGE 900
            PSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGE
Sbjct: 841  PSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGE 900

Query: 901  FDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHC 960
            FDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHC
Sbjct: 901  FDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHC 960

Query: 961  AASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN 1020
            AASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN
Sbjct: 961  AASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN 1020

Query: 1021 KGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYP 1080
            KGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYP
Sbjct: 1021 KGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYP 1080

Query: 1081 RIKPRQRTLA 1090
            RIKPRQRTLA
Sbjct: 1081 RIKPRQRTLA 1090


>gi|112799849 tumor protein p53 binding protein, 2 isoform 1 [Homo
            sapiens]
          Length = 1134

 Score =  951 bits (2458), Expect = 0.0
 Identities = 551/1154 (47%), Positives = 703/1154 (60%), Gaps = 90/1154 (7%)

Query: 1    MMPMILTVFLSNNEQILTEVPITPETTCRDVVEFCKEPGEGSCHLAEVWRGNERPIPFDH 60
            MMPM LTV+LSNNEQ  TEVP+TPET CRDVV+ CKEPGE  CHLAEVW G+ERP+  + 
Sbjct: 7    MMPMFLTVYLSNNEQHFTEVPVTPETICRDVVDLCKEPGESDCHLAEVWCGSERPVADNE 66

Query: 61   MMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGE-KRTENGV 119
             M++ LQ++G +R EV+FFLRHE  P  +   G R +Q+   +RN + VPGE +R ENGV
Sbjct: 67   RMFDVLQRFGSQRNEVRFFLRHERPPGRDIVSGPR-SQDPSLKRNGVKVPGEYRRKENGV 125

Query: 120  GNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKL 179
             +PR++LTL+ELQ+MA+RQQQQIE QQQ+L  KEQRL FLKQQ++RQQQ ++E EKL++L
Sbjct: 126  NSPRMDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLKQQDQRQQQQVAEQEKLKRL 185

Query: 180  KERVEAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLS 239
            KE  E QE KLKK+RA++G V+  ++ NG L  EIE+ + +FQ+K++E+  A+ +V++L+
Sbjct: 186  KEIAENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSKVEELT 245

Query: 240  QQLEDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKR 299
            +QLE LK G+++            A  EL RLY+ELQ+RN+LNQEQN+KLQQQ+E LNKR
Sbjct: 246  RQLEMLKNGRIDSHHDNQS-----AVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKR 300

Query: 300  NMEVAMMDKRISELRERLYGKKIQLNRVNGT------SSPQSPLSTSGRVAAVGPYIQVP 353
            N EVA+MDKR++ELR+RL+ KK  L +          + PQ   S   RVAAVGPYIQ  
Sbjct: 301  NSEVAVMDKRVNELRDRLWKKKAALQQKENLPVSSDGNLPQQAASAPSRVAAVGPYIQSS 360

Query: 354  SAGSFP----VLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVK--PVQVAG 407
            +    P    +L  P  P   S+   A+ G  K       P ++  ++S  K   +   G
Sbjct: 361  TMPRMPSRPELLVKPALPDG-SLVIQASEGPMKIQ---TLPNMRSGAASQTKGSKIHPVG 416

Query: 408  ADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVG-------KQLPP 460
             DW   + +    QG+ S      +AL   +   + + +    +              PP
Sbjct: 417  PDWSPSNADLFPSQGSASVPQSTGNALDQVDDGEVPLREKEKKVRPFSMFDAVDQSNAPP 476

Query: 461  SYGTY-PSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQP------- 512
            S+GT   + +       + +  +    +P P   +P++ +   LP  G T QP       
Sbjct: 477  SFGTLRKNQSSEDILRDAQVANKNVAKVPPP---VPTKPKQINLPYFGQTNQPPSDIKPD 533

Query: 513  GSSQQIQ--------------QRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLA 558
            GSSQQ+               Q+  V  SP+ P  G     +  SK E P   A+RPF  
Sbjct: 534  GSSQQLSTVVPSMGTKPKPAGQQPRVLLSPSIPSVGQDQTLSPGSKQESPPAAAVRPFTP 593

Query: 559  DKGSRP-QSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKS------VKAVYGK 611
                     P + PQTV +SSIYSMY QQ  P KN+Q A  SAL K+        +VYGK
Sbjct: 594  QPSKDTLLPPFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPHFSSVYGK 653

Query: 612  PVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLS 671
            PV+ +           H        Q +P S     EPE +  ++  +    E +PRPLS
Sbjct: 654  PVIAAAQNQQQ-----HPENIYSNSQGKPGS----PEPETEPVSSVQENHENERIPRPLS 704

Query: 672  PTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFN 731
            PTKL P + +P R QSDADLEALR+KL+NAPRPLKKRSSITEPEGP GPNIQKLLYQR  
Sbjct: 705  PTKLLPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTT 764

Query: 732  TLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDA 791
              A      P Y    +     + + V+  N   +   E+   +     L  E   ++  
Sbjct: 765  IAAMETISVPSYPSKSASVTASSESPVEIQNPYLHVEPEKEVVSLVPESLSPEDVGNAST 824

Query: 792  NDNELPSPEP----EELICPQTTHQTAEPAEDNNNNVATV--------PTTEQIPSPVAE 839
             ++++P+P P    E    P  +       E+ N     V        P     P P  E
Sbjct: 825  ENSDMPAPSPGLDYEPEGVPDNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGE 884

Query: 840  APSPGEEQV---PPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDAS 896
               PGE+ V   PP      S PP     KRTNL+K  SER  HG+RV+FNPLALLLD+S
Sbjct: 885  PEGPGEDSVSMRPPEITGQVSLPP----GKRTNLRKTGSERIAHGMRVKFNPLALLLDSS 940

Query: 897  LEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWT 956
            LEGEFDLVQRIIYEV+DPS PNDEGIT LHNAVCAGH  IVKFL+ FGVNVNAADSDGWT
Sbjct: 941  LEGEFDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWT 1000

Query: 957  PLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKL 1016
            PLHCAASCN+V +CK LVESGAA+FA T SD++TAADKCEEMEEGY QCSQFLYGVQEK+
Sbjct: 1001 PLHCAASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKM 1060

Query: 1017 GVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLL 1076
            G+MNKGV YALWDYE QN DEL   EGD +TI+ R+DE E EWWWARL D+EGYVP+NLL
Sbjct: 1061 GIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRNLL 1120

Query: 1077 GLYPRIKPRQRTLA 1090
            GLYPRIKPRQR+LA
Sbjct: 1121 GLYPRIKPRQRSLA 1134


>gi|4885643 tumor protein p53 binding protein, 2 isoform 2 [Homo
            sapiens]
          Length = 1005

 Score =  805 bits (2078), Expect = 0.0
 Identities = 478/1030 (46%), Positives = 611/1030 (59%), Gaps = 88/1030 (8%)

Query: 124  VELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERV 183
            ++LTL+ELQ+MA+RQQQQIE QQQ+L  KEQRL FLKQQ++RQQQ ++E EKL++LKE  
Sbjct: 1    MDLTLAELQEMASRQQQQIEAQQQLLATKEQRLKFLKQQDQRQQQQVAEQEKLKRLKEIA 60

Query: 184  EAQENKLKKIRAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLE 243
            E QE KLKK+RA++G V+  ++ NG L  EIE+ + +FQ+K++E+  A+ +V++L++QLE
Sbjct: 61   ENQEAKLKKVRALKGHVEQKRLSNGKLVEEIEQMNNLFQQKQRELVLAVSKVEELTRQLE 120

Query: 244  DLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEV 303
             LK G+++            A  EL RLY+ELQ+RN+LNQEQN+KLQQQ+E LNKRN EV
Sbjct: 121  MLKNGRIDSHHDNQS-----AVAELDRLYKELQLRNKLNQEQNAKLQQQRECLNKRNSEV 175

Query: 304  AMMDKRISELRERLYGKKIQLNRVNGT------SSPQSPLSTSGRVAAVGPYIQVPSAGS 357
            A+MDKR++ELR+RL+ KK  L +          + PQ   S   RVAAVGPYIQ  +   
Sbjct: 176  AVMDKRVNELRDRLWKKKAALQQKENLPVSSDGNLPQQAASAPSRVAAVGPYIQSSTMPR 235

Query: 358  FP----VLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVK--PVQVAGADWK 411
             P    +L  P  P   S+   A+ G  K       P ++  ++S  K   +   G DW 
Sbjct: 236  MPSRPELLVKPALPDG-SLVIQASEGPMKIQ---TLPNMRSGAASQTKGSKIHPVGPDWS 291

Query: 412  DPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVG-------KQLPPSYGT 464
              + +    QG+ S      +AL   +   + + +    +              PPS+GT
Sbjct: 292  PSNADLFPSQGSASVPQSTGNALDQVDDGEVPLREKEKKVRPFSMFDAVDQSNAPPSFGT 351

Query: 465  Y-PSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQP-------GSSQ 516
               + +       + +  +    +P P   +P++ +   LP  G T QP       GSSQ
Sbjct: 352  LRKNQSSEDILRDAQVANKNVAKVPPP---VPTKPKQINLPYFGQTNQPPSDIKPDGSSQ 408

Query: 517  QIQ--------------QRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGS 562
            Q+               Q+  V  SP+ P  G     +  SK E P   A+RPF      
Sbjct: 409  QLSTVVPSMGTKPKPAGQQPRVLLSPSIPSVGQDQTLSPGSKQESPPAAAVRPFTPQPSK 468

Query: 563  RP-QSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKS------VKAVYGKPVLP 615
                 P + PQTV +SSIYSMY QQ  P KN+Q A  SAL K+        +VYGKPV+ 
Sbjct: 469  DTLLPPFRKPQTVAASSIYSMYTQQQAPGKNFQQAVQSALTKTHTRGPHFSSVYGKPVIA 528

Query: 616  SGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKL 675
            +           H        Q +P S     EPE +  ++  +    E +PRPLSPTKL
Sbjct: 529  AAQNQQQ-----HPENIYSNSQGKPGS----PEPETEPVSSVQENHENERIPRPLSPTKL 579

Query: 676  TPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAG 735
             P + +P R QSDADLEALR+KL+NAPRPLKKRSSITEPEGP GPNIQKLLYQR    A 
Sbjct: 580  LPFLSNPYRNQSDADLEALRKKLSNAPRPLKKRSSITEPEGPNGPNIQKLLYQRTTIAAM 639

Query: 736  GMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNE 795
                 P Y    +     + + V+  N   +   E+   +     L  E   ++   +++
Sbjct: 640  ETISVPSYPSKSASVTASSESPVEIQNPYLHVEPEKEVVSLVPESLSPEDVGNASTENSD 699

Query: 796  LPSPEP----EELICPQTTHQTAEPAEDNNNNVATV--------PTTEQIPSPVAEAPSP 843
            +P+P P    E    P  +       E+ N     V        P     P P  E   P
Sbjct: 700  MPAPSPGLDYEPEGVPDNSPNLQNNPEEPNPEAPHVLDVYLEEYPPYPPPPYPSGEPEGP 759

Query: 844  GEEQV---PPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEGE 900
            GE+ V   PP      S PP     KRTNL+K  SER  HG+RV+FNPLALLLD+SLEGE
Sbjct: 760  GEDSVSMRPPEITGQVSLPP----GKRTNLRKTGSERIAHGMRVKFNPLALLLDSSLEGE 815

Query: 901  FDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHC 960
            FDLVQRIIYEV+DPS PNDEGIT LHNAVCAGH  IVKFL+ FGVNVNAADSDGWTPLHC
Sbjct: 816  FDLVQRIIYEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHC 875

Query: 961  AASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKLGVMN 1020
            AASCN+V +CK LVESGAA+FA T SD++TAADKCEEMEEGY QCSQFLYGVQEK+G+MN
Sbjct: 876  AASCNNVQVCKFLVESGAAVFAMTYSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMN 935

Query: 1021 KGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYVPKNLLGLYP 1080
            KGV YALWDYE QN DEL   EGD +TI+ R+DE E EWWWARL D+EGYVP+NLLGLYP
Sbjct: 936  KGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRNLLGLYP 995

Query: 1081 RIKPRQRTLA 1090
            RIKPRQR+LA
Sbjct: 996  RIKPRQRSLA 1005


>gi|215820635 protein phosphatase 1, regulatory subunit 13 like [Homo
            sapiens]
          Length = 828

 Score =  296 bits (759), Expect = 5e-80
 Identities = 261/855 (30%), Positives = 374/855 (43%), Gaps = 118/855 (13%)

Query: 296  LNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSA 355
            ++ + ME+     ++ EL ++L            + SP  P   +G  +    Y      
Sbjct: 25   MDLKQMELDTAAAKVDELTKQLESL--------WSDSPAPPGPQAGPPSRPPRYSSSSIP 76

Query: 356  GSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVK--PVQVAGADWKDP 413
              F   G P K  + +  ++   GRS+SA     PTL   S  S K  P       +  P
Sbjct: 77   EPFGSRGSPRK--AATDGADTPFGRSESA-----PTLHPYSPLSPKGRPSSPRTPLYLQP 129

Query: 414  SVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVG---KQLPPSYGTY----- 465
               GS+ + T S +P  F   G +      +G+ P P PG G   +Q PP+   +     
Sbjct: 130  DAYGSLDRAT-SPRPRAFDGAGSS------LGRAPSPRPGPGPLRQQGPPTPFDFLGRAG 182

Query: 466  -PSPTPLGPGSTSSLERRKEGSLPRPSAGL----PSRQRPTLLPATGSTPQPGSSQQIQQ 520
             P  +PL  G  +    R  G  PRP A       S    +LL + GS   P    Q   
Sbjct: 183  SPRGSPLAEGPQAFFPER--GPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDL 240

Query: 521  RISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIY 580
             +   P   +  +      A + KP    +        D  +RP SP         SS+ 
Sbjct: 241  TLRRRPPKAWNESDLDV--AYEKKPSQTASYE----RLDVFARPASPSLQLLPWRESSLD 294

Query: 581  SM------YLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTG 634
             +       L  AT P+NY+ +  ++  +S    Y + +   GS  PS    L  S    
Sbjct: 295  GLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSL---GSAGPSGT--LPRSWQPV 349

Query: 635  TPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPL--SPTKLTPIVHSPLRYQSDADLE 692
            +  P PPS     +P       P   S +  L             +  SPL  ++     
Sbjct: 350  SRIPMPPSSP---QPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPP-- 404

Query: 693  ALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLL--------YQRFNTLAGGMEGTPFYQ 744
                KL   P+P  +  S  +P+ P  P  Q            Q +  +  G    P  +
Sbjct: 405  ----KLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPTPAPQHPQQTWPPVNEGPPKPPT-E 459

Query: 745  PSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEEL 804
              P  +  G L  V        G+++E P A+P +P   +PA   +A    +P  E    
Sbjct: 460  LEPEPEIEGLLTPVLEA-----GDVDEGPVARPLSPTRLQPALPPEAQS--VPELEEVAR 512

Query: 805  ICPQTTHQTAEPAEDNNNNVATVPTT-----EQIPSPVAE---APSPGEEQV-------- 848
            +  +                  +P T     +QI S +      P PG  +         
Sbjct: 513  VLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEG 572

Query: 849  ------PPAPLPPASHPPAT-----------STNKRTNLKKPNSERTGHGLRVRFNPLAL 891
                  PPAP PPA  PP             S   R+ L+K  S R     R R NPL L
Sbjct: 573  SEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGSPRKAR--RARLNPLVL 630

Query: 892  LLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAAD 951
            LLDA+L GE ++VQ+ + E+ DPS+PN+EGIT LHNA+C  ++ IV FL+  G NVN+ D
Sbjct: 631  LLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPD 690

Query: 952  SDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYG 1011
            S GWTPLHCAASCN   +C  LV+ GAAIFA+T+SD  TA +KC+   EGY  C+ +L  
Sbjct: 691  SHGWTPLHCAASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLAD 750

Query: 1012 VQEKLGVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYV 1071
            V++ +G+MN G  YALWDY A+  DELSF EG+++T+LRR    ET+WWWA L  +EGYV
Sbjct: 751  VEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYV 810

Query: 1072 PKNLLGLYPRIKPRQ 1086
            P+N  GL+PR+KP++
Sbjct: 811  PRNYFGLFPRVKPQR 825


>gi|63003907 protein phosphatase 1, regulatory subunit 13 like [Homo
            sapiens]
          Length = 828

 Score =  296 bits (759), Expect = 5e-80
 Identities = 261/855 (30%), Positives = 374/855 (43%), Gaps = 118/855 (13%)

Query: 296  LNKRNMEVAMMDKRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSA 355
            ++ + ME+     ++ EL ++L            + SP  P   +G  +    Y      
Sbjct: 25   MDLKQMELDTAAAKVDELTKQLESL--------WSDSPAPPGPQAGPPSRPPRYSSSSIP 76

Query: 356  GSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVK--PVQVAGADWKDP 413
              F   G P K  + +  ++   GRS+SA     PTL   S  S K  P       +  P
Sbjct: 77   EPFGSRGSPRK--AATDGADTPFGRSESA-----PTLHPYSPLSPKGRPSSPRTPLYLQP 129

Query: 414  SVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVG---KQLPPSYGTY----- 465
               GS+ + T S +P  F   G +      +G+ P P PG G   +Q PP+   +     
Sbjct: 130  DAYGSLDRAT-SPRPRAFDGAGSS------LGRAPSPRPGPGPLRQQGPPTPFDFLGRAG 182

Query: 466  -PSPTPLGPGSTSSLERRKEGSLPRPSAGL----PSRQRPTLLPATGSTPQPGSSQQIQQ 520
             P  +PL  G  +    R  G  PRP A       S    +LL + GS   P    Q   
Sbjct: 183  SPRGSPLAEGPQAFFPER--GPSPRPPATAYDAPASAFGSSLLGSGGSAFAPPLRAQDDL 240

Query: 521  RISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIY 580
             +   P   +  +      A + KP    +        D  +RP SP         SS+ 
Sbjct: 241  TLRRRPPKAWNESDLDV--AYEKKPSQTASYE----RLDVFARPASPSLQLLPWRESSLD 294

Query: 581  SM------YLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTG 634
             +       L  AT P+NY+ +  ++  +S    Y + +   GS  PS    L  S    
Sbjct: 295  GLGGTGKDNLTSATLPRNYKVSPLASDRRSDAGSYRRSL---GSAGPSGT--LPRSWQPV 349

Query: 635  TPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPL--SPTKLTPIVHSPLRYQSDADLE 692
            +  P PPS     +P       P   S +  L             +  SPL  ++     
Sbjct: 350  SRIPMPPSSP---QPRGAPRQRPIPLSMIFKLQNAFWEHGASRAMLPGSPLFTRAPPP-- 404

Query: 693  ALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLL--------YQRFNTLAGGMEGTPFYQ 744
                KL   P+P  +  S  +P+ P  P  Q            Q +  +  G    P  +
Sbjct: 405  ----KLQPQPQPQPQPQSQPQPQLPPQPQTQPQTPTPAPQHPQQTWPPVNEGPPKPPT-E 459

Query: 745  PSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEEL 804
              P  +  G L  V        G+++E P A+P +P   +PA   +A    +P  E    
Sbjct: 460  LEPEPEIEGLLTPVLEA-----GDVDEGPVARPLSPTRLQPALPPEAQS--VPELEEVAR 512

Query: 805  ICPQTTHQTAEPAEDNNNNVATVPTT-----EQIPSPVAE---APSPGEEQV-------- 848
            +  +                  +P T     +QI S +      P PG  +         
Sbjct: 513  VLAEIPRPLKRRGSMEQAPAVALPPTHKKQYQQIISRLFHRHGGPGPGGPEPELSPITEG 572

Query: 849  ------PPAPLPPASHPPAT-----------STNKRTNLKKPNSERTGHGLRVRFNPLAL 891
                  PPAP PPA  PP             S   R+ L+K  S R     R R NPL L
Sbjct: 573  SEARAGPPAPAPPAPIPPPAPSQSSPPEQPQSMEMRSVLRKAGSPRKAR--RARLNPLVL 630

Query: 892  LLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAAD 951
            LLDA+L GE ++VQ+ + E+ DPS+PN+EGIT LHNA+C  ++ IV FL+  G NVN+ D
Sbjct: 631  LLDAALTGELEVVQQAVKEMNDPSQPNEEGITALHNAICGANYSIVDFLITAGANVNSPD 690

Query: 952  SDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEEMEEGYIQCSQFLYG 1011
            S GWTPLHCAASCN   +C  LV+ GAAIFA+T+SD  TA +KC+   EGY  C+ +L  
Sbjct: 691  SHGWTPLHCAASCNDTVICMALVQHGAAIFATTLSDGATAFEKCDPYREGYADCATYLAD 750

Query: 1012 VQEKLGVMNKGVAYALWDYEAQNSDELSFHEGDALTILRRKDESETEWWWARLGDREGYV 1071
            V++ +G+MN G  YALWDY A+  DELSF EG+++T+LRR    ET+WWWA L  +EGYV
Sbjct: 751  VEQSMGLMNSGAVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWAALHGQEGYV 810

Query: 1072 PKNLLGLYPRIKPRQ 1086
            P+N  GL+PR+KP++
Sbjct: 811  PRNYFGLFPRVKPQR 825


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 126/564 (22%), Positives = 193/564 (34%), Gaps = 51/564 (9%)

Query: 331 SSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWP 390
           ++P+ P  T+ + A   P    P+    P    P +P   +    A      +      P
Sbjct: 242 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 301

Query: 391 T-LKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
                   +   P + A    K+P+     +    + +P P +   P      +     P
Sbjct: 302 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 361

Query: 450 --PIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTL---- 502
             P P   K+  P+    PSPT P  P  T++         P P+    ++  PT     
Sbjct: 362 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT---TKSAPTTPKEP 418

Query: 503 LPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGS 562
            P T   P P + ++        P+PT P    P  P    K   P T         K  
Sbjct: 419 SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPAPTTTKKPAPTTPKEP 474

Query: 563 RPQSPRK-GPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSP 621
            P +P++  P T    +  +      T P+   P     L  +       P  P+ +T  
Sbjct: 475 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT------PEEPTPTTPE 528

Query: 622 SPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGS---TVESLPRPLSPTKL--- 675
            P P    + +  TP+   P+ +T KEP    P  PA  +   T  + P+  +PT L   
Sbjct: 529 EPAPTTPKAAAPNTPKE--PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 586

Query: 676 ---TPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNT 732
              TP   +P         E              K ++ T P+ P  P   K   +   T
Sbjct: 587 APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-PTTPK---EPAPT 642

Query: 733 LAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP------LPAEPA 786
              G   T   +P+P+        ++    T    +     PA PT P       P EPA
Sbjct: 643 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA-PTTPKETAPTTPKEPA 701

Query: 787 PSSDANDN----ELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPS 842
           P++         E P P   E+  P TT    EP   + +   + P     P+P A   S
Sbjct: 702 PTTPKKPAPTTPETPPPTTSEVSTPTTTK---EPTTIHKSPDESTPELSAEPTPKALENS 758

Query: 843 PGEEQVPPAPLPPASHPPATSTNK 866
           P E  VP    P A+ P  T+T K
Sbjct: 759 PKEPGVPTTKTPAATKPEMTTTAK 782



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 96/453 (21%), Positives = 146/453 (32%), Gaps = 95/453 (20%)

Query: 448 PPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATG 507
           PP +   G  L    G +   TP     TS+ +  K  + P+ +   P   RP+L P + 
Sbjct: 82  PPVVDEAGSGL--DNGDFKVTTP----DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 135

Query: 508 STPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRP-----------F 556
           ++ +  +S  + +  +V    T       +    +       T +I              
Sbjct: 136 TSKE--TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV 193

Query: 557 LADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPS 616
           LA    + ++  KGP             ++ TP    +PA+ +    +   +   P  P 
Sbjct: 194 LAKPTPKAETTTKGPALTTP--------KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 245

Query: 617 GSTSPSPLPFLHGSLSTGTPQPQP-----PSESTEKEPEQDGPAAPADGSTVESLPRPLS 671
                 P P    S  T   +P P     P+ +T KEP       PA  +T  +   P  
Sbjct: 246 -----EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 300

Query: 672 PTKLTPIVHSPLRYQSDADLEALRRK--LANAPRPLKKRSSITEPEGPGGPNIQKLLYQR 729
           P   TP   +P   +  A              P P  K  + T P+ P  P   K     
Sbjct: 301 PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA-PTAPK----- 354

Query: 730 FNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSS 789
                         +P+P+                         P +P    P EPAP++
Sbjct: 355 --------------KPAPTT------------------------PKEPAPTTPKEPAPTT 376

Query: 790 DANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVA---EAPSPGEE 846
               +     EP           T EPA        + PTT + PSP      AP+  +E
Sbjct: 377 TKEPSPTTPKEPAPTTTKSAPTTTKEPAP---TTTKSAPTTPKEPSPTTTKEPAPTTPKE 433

Query: 847 QVPPAPLPPA---SHPPATSTNKR---TNLKKP 873
             P  P  PA      PA +T K    T  KKP
Sbjct: 434 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 466



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 105/512 (20%), Positives = 160/512 (31%), Gaps = 81/512 (15%)

Query: 423 TVSSQPVPFSALGP----TEKPGIEIGKVPPPI------PGVGKQLPPSYGTYPSPTPLG 472
           T   +P P +   P    T+KP     K P P       P   K+L P+     +PT   
Sbjct: 445 TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 504

Query: 473 PGSTSSLERRKEGSLPRPSAGLPSRQRPTL----LPATGSTPQPGSSQQIQQRISVPPSP 528
             + ++ E     +   P+   P    PT      P T   P P + ++        P+P
Sbjct: 505 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 564

Query: 529 TYPPAGPPAFPAGDSK----------PELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSS 578
           T P    P  P G +           P+ P    + P    + +     +  P T   ++
Sbjct: 565 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 624

Query: 579 IYSMYLQQATPPKNYQPA-----AHSALNKSVKAVYGKPVL----------PSGSTSPSP 623
             +      T PK   P      A + L +       KP            P+ +TS  P
Sbjct: 625 PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 684

Query: 624 LPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPL 683
            P       T    P+ P+ +T K+P    P  P    T   +  P +  + T I  SP 
Sbjct: 685 APTT--PKETAPTTPKEPAPTTPKKPAPTTPETPPP--TTSEVSTPTTTKEPTTIHKSPD 740

Query: 684 RYQSDADLEALRRKLANAPR----PLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEG 739
               +   E   + L N+P+    P  K  + T+PE             +  T    +  
Sbjct: 741 ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE--------MTTTAKDKTTERDLRT 792

Query: 740 TP---FYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEP------APSSD 790
           TP      P  +++   T          A          Q T P           AP   
Sbjct: 793 TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 852

Query: 791 ANDNELPSPE----PEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEE 846
                + + E    PEE         TA+P +   N+ AT P     P    +AP     
Sbjct: 853 TTKKTITTTEIMNKPEE---------TAKPKDRATNSKATTPK----PQKPTKAPKKPTS 899

Query: 847 QVPPAPLPPASHPPATSTNKRTNLKKPNSERT 878
              P  +P    P  T T ++     P    T
Sbjct: 900 TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 931



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 79/385 (20%), Positives = 133/385 (34%), Gaps = 53/385 (13%)

Query: 331 SSPQSPLSTSGR-VAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNW 389
           ++P+ P  T+ +  A   P    P+    P    P KP    +A       + +  D   
Sbjct: 557 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 616

Query: 390 PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSS---QPVPFSA-------LGPTEK 439
           PT  + ++ +  P + A    K+P+   +  +GT  +   +P P +        L PT  
Sbjct: 617 PTTPKGTAPTT-PKEPAPTTPKEPAP--TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 673

Query: 440 PGIEIGKVPPPIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQ 498
            G        P P   K+  P+    P+PT P  P  T+          P P+    S  
Sbjct: 674 KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP-------ETPPPTTSEVSTP 726

Query: 499 RPTLLPAT------GSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVA 552
             T  P T       STP+  +    +   + P  P  P    PA     +KPE+  T  
Sbjct: 727 TTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAK 782

Query: 553 IRPFLADKGSRPQSPRKGPQ-----------------TVNSSSIYSMYLQQATPPKNYQP 595
            +    D  + P++    P+                 T  ++ + S   Q  TP K    
Sbjct: 783 DKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTL 842

Query: 596 AAHSALNK---SVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQD 652
              +   K   + K +    ++     +  P      S +T TP+PQ P+++ +K     
Sbjct: 843 KTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT-TPKPQKPTKAPKKPTSTK 901

Query: 653 GPAAPADGSTVESLPRPLSPTKLTP 677
            P         ++ P P   T   P
Sbjct: 902 KPKTMPRVRKPKTTPTPRKMTSTMP 926


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 126/564 (22%), Positives = 193/564 (34%), Gaps = 51/564 (9%)

Query: 331 SSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWP 390
           ++P+ P  T+ + A   P    P+    P    P +P   +    A      +      P
Sbjct: 283 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 342

Query: 391 T-LKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
                   +   P + A    K+P+     +    + +P P +   P      +     P
Sbjct: 343 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 402

Query: 450 --PIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTL---- 502
             P P   K+  P+    PSPT P  P  T++         P P+    ++  PT     
Sbjct: 403 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT---TKSAPTTPKEP 459

Query: 503 LPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGS 562
            P T   P P + ++        P+PT P    P  P    K   P T         K  
Sbjct: 460 SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPAPTTTKKPAPTTPKEP 515

Query: 563 RPQSPRK-GPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSP 621
            P +P++  P T    +  +      T P+   P     L  +       P  P+ +T  
Sbjct: 516 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT------PEEPTPTTPE 569

Query: 622 SPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGS---TVESLPRPLSPTKL--- 675
            P P    + +  TP+   P+ +T KEP    P  PA  +   T  + P+  +PT L   
Sbjct: 570 EPAPTTPKAAAPNTPKE--PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 627

Query: 676 ---TPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNT 732
              TP   +P         E              K ++ T P+ P  P   K   +   T
Sbjct: 628 APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-PTTPK---EPAPT 683

Query: 733 LAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP------LPAEPA 786
              G   T   +P+P+        ++    T    +     PA PT P       P EPA
Sbjct: 684 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA-PTTPKETAPTTPKEPA 742

Query: 787 PSSDANDN----ELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPS 842
           P++         E P P   E+  P TT    EP   + +   + P     P+P A   S
Sbjct: 743 PTTPKKPAPTTPETPPPTTSEVSTPTTTK---EPTTIHKSPDESTPELSAEPTPKALENS 799

Query: 843 PGEEQVPPAPLPPASHPPATSTNK 866
           P E  VP    P A+ P  T+T K
Sbjct: 800 PKEPGVPTTKTPAATKPEMTTTAK 823



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 96/453 (21%), Positives = 146/453 (32%), Gaps = 95/453 (20%)

Query: 448 PPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATG 507
           PP +   G  L    G +   TP     TS+ +  K  + P+ +   P   RP+L P + 
Sbjct: 123 PPVVDEAGSGL--DNGDFKVTTP----DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 176

Query: 508 STPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRP-----------F 556
           ++ +  +S  + +  +V    T       +    +       T +I              
Sbjct: 177 TSKE--TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV 234

Query: 557 LADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPS 616
           LA    + ++  KGP             ++ TP    +PA+ +    +   +   P  P 
Sbjct: 235 LAKPTPKAETTTKGPALTTP--------KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 286

Query: 617 GSTSPSPLPFLHGSLSTGTPQPQP-----PSESTEKEPEQDGPAAPADGSTVESLPRPLS 671
                 P P    S  T   +P P     P+ +T KEP       PA  +T  +   P  
Sbjct: 287 -----EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 341

Query: 672 PTKLTPIVHSPLRYQSDADLEALRRK--LANAPRPLKKRSSITEPEGPGGPNIQKLLYQR 729
           P   TP   +P   +  A              P P  K  + T P+ P  P   K     
Sbjct: 342 PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA-PTAPK----- 395

Query: 730 FNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSS 789
                         +P+P+                         P +P    P EPAP++
Sbjct: 396 --------------KPAPTT------------------------PKEPAPTTPKEPAPTT 417

Query: 790 DANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVA---EAPSPGEE 846
               +     EP           T EPA        + PTT + PSP      AP+  +E
Sbjct: 418 TKEPSPTTPKEPAPTTTKSAPTTTKEPAP---TTTKSAPTTPKEPSPTTTKEPAPTTPKE 474

Query: 847 QVPPAPLPPA---SHPPATSTNKR---TNLKKP 873
             P  P  PA      PA +T K    T  KKP
Sbjct: 475 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 507



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 105/512 (20%), Positives = 160/512 (31%), Gaps = 81/512 (15%)

Query: 423 TVSSQPVPFSALGP----TEKPGIEIGKVPPPI------PGVGKQLPPSYGTYPSPTPLG 472
           T   +P P +   P    T+KP     K P P       P   K+L P+     +PT   
Sbjct: 486 TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 545

Query: 473 PGSTSSLERRKEGSLPRPSAGLPSRQRPTL----LPATGSTPQPGSSQQIQQRISVPPSP 528
             + ++ E     +   P+   P    PT      P T   P P + ++        P+P
Sbjct: 546 KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 605

Query: 529 TYPPAGPPAFPAGDSK----------PELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSS 578
           T P    P  P G +           P+ P    + P    + +     +  P T   ++
Sbjct: 606 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 665

Query: 579 IYSMYLQQATPPKNYQPA-----AHSALNKSVKAVYGKPVL----------PSGSTSPSP 623
             +      T PK   P      A + L +       KP            P+ +TS  P
Sbjct: 666 PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 725

Query: 624 LPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPL 683
            P       T    P+ P+ +T K+P    P  P    T   +  P +  + T I  SP 
Sbjct: 726 APTT--PKETAPTTPKEPAPTTPKKPAPTTPETPPP--TTSEVSTPTTTKEPTTIHKSPD 781

Query: 684 RYQSDADLEALRRKLANAPR----PLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEG 739
               +   E   + L N+P+    P  K  + T+PE             +  T    +  
Sbjct: 782 ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE--------MTTTAKDKTTERDLRT 833

Query: 740 TP---FYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEP------APSSD 790
           TP      P  +++   T          A          Q T P           AP   
Sbjct: 834 TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 893

Query: 791 ANDNELPSPE----PEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEE 846
                + + E    PEE         TA+P +   N+ AT P     P    +AP     
Sbjct: 894 TTKKTITTTEIMNKPEE---------TAKPKDRATNSKATTPK----PQKPTKAPKKPTS 940

Query: 847 QVPPAPLPPASHPPATSTNKRTNLKKPNSERT 878
              P  +P    P  T T ++     P    T
Sbjct: 941 TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 972



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 79/385 (20%), Positives = 133/385 (34%), Gaps = 53/385 (13%)

Query: 331 SSPQSPLSTSGR-VAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNW 389
           ++P+ P  T+ +  A   P    P+    P    P KP    +A       + +  D   
Sbjct: 598 TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 657

Query: 390 PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSS---QPVPFSA-------LGPTEK 439
           PT  + ++ +  P + A    K+P+   +  +GT  +   +P P +        L PT  
Sbjct: 658 PTTPKGTAPTT-PKEPAPTTPKEPAP--TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 714

Query: 440 PGIEIGKVPPPIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQ 498
            G        P P   K+  P+    P+PT P  P  T+          P P+    S  
Sbjct: 715 KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP-------ETPPPTTSEVSTP 767

Query: 499 RPTLLPAT------GSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVA 552
             T  P T       STP+  +    +   + P  P  P    PA     +KPE+  T  
Sbjct: 768 TTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAK 823

Query: 553 IRPFLADKGSRPQSPRKGPQ-----------------TVNSSSIYSMYLQQATPPKNYQP 595
            +    D  + P++    P+                 T  ++ + S   Q  TP K    
Sbjct: 824 DKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTL 883

Query: 596 AAHSALNK---SVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQD 652
              +   K   + K +    ++     +  P      S +T TP+PQ P+++ +K     
Sbjct: 884 KTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT-TPKPQKPTKAPKKPTSTK 942

Query: 653 GPAAPADGSTVESLPRPLSPTKLTP 677
            P         ++ P P   T   P
Sbjct: 943 KPKTMPRVRKPKTTPTPRKMTSTMP 967


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 126/564 (22%), Positives = 193/564 (34%), Gaps = 51/564 (9%)

Query: 331 SSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWP 390
           ++P+ P  T+ + A   P    P+    P    P +P   +    A      +      P
Sbjct: 335 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 394

Query: 391 T-LKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
                   +   P + A    K+P+     +    + +P P +   P      +     P
Sbjct: 395 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 454

Query: 450 --PIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTL---- 502
             P P   K+  P+    PSPT P  P  T++         P P+    ++  PT     
Sbjct: 455 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT---TKSAPTTPKEP 511

Query: 503 LPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGS 562
            P T   P P + ++        P+PT P    P  P    K   P T         K  
Sbjct: 512 SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPAPTTTKKPAPTTPKEP 567

Query: 563 RPQSPRK-GPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSP 621
            P +P++  P T    +  +      T P+   P     L  +       P  P+ +T  
Sbjct: 568 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT------PEEPTPTTPE 621

Query: 622 SPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGS---TVESLPRPLSPTKL--- 675
            P P    + +  TP+   P+ +T KEP    P  PA  +   T  + P+  +PT L   
Sbjct: 622 EPAPTTPKAAAPNTPKE--PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 679

Query: 676 ---TPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNT 732
              TP   +P         E              K ++ T P+ P  P   K   +   T
Sbjct: 680 APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-PTTPK---EPAPT 735

Query: 733 LAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP------LPAEPA 786
              G   T   +P+P+        ++    T    +     PA PT P       P EPA
Sbjct: 736 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA-PTTPKETAPTTPKEPA 794

Query: 787 PSSDANDN----ELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPS 842
           P++         E P P   E+  P TT    EP   + +   + P     P+P A   S
Sbjct: 795 PTTPKKPAPTTPETPPPTTSEVSTPTTTK---EPTTIHKSPDESTPELSAEPTPKALENS 851

Query: 843 PGEEQVPPAPLPPASHPPATSTNK 866
           P E  VP    P A+ P  T+T K
Sbjct: 852 PKEPGVPTTKTPAATKPEMTTTAK 875



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 96/453 (21%), Positives = 146/453 (32%), Gaps = 95/453 (20%)

Query: 448 PPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATG 507
           PP +   G  L    G +   TP     TS+ +  K  + P+ +   P   RP+L P + 
Sbjct: 175 PPVVDEAGSGL--DNGDFKVTTP----DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 228

Query: 508 STPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRP-----------F 556
           ++ +  +S  + +  +V    T       +    +       T +I              
Sbjct: 229 TSKE--TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV 286

Query: 557 LADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPS 616
           LA    + ++  KGP             ++ TP    +PA+ +    +   +   P  P 
Sbjct: 287 LAKPTPKAETTTKGPALTTP--------KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 338

Query: 617 GSTSPSPLPFLHGSLSTGTPQPQP-----PSESTEKEPEQDGPAAPADGSTVESLPRPLS 671
                 P P    S  T   +P P     P+ +T KEP       PA  +T  +   P  
Sbjct: 339 -----EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 393

Query: 672 PTKLTPIVHSPLRYQSDADLEALRRK--LANAPRPLKKRSSITEPEGPGGPNIQKLLYQR 729
           P   TP   +P   +  A              P P  K  + T P+ P  P   K     
Sbjct: 394 PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA-PTAPK----- 447

Query: 730 FNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSS 789
                         +P+P+                         P +P    P EPAP++
Sbjct: 448 --------------KPAPTT------------------------PKEPAPTTPKEPAPTT 469

Query: 790 DANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVA---EAPSPGEE 846
               +     EP           T EPA        + PTT + PSP      AP+  +E
Sbjct: 470 TKEPSPTTPKEPAPTTTKSAPTTTKEPAP---TTTKSAPTTPKEPSPTTTKEPAPTTPKE 526

Query: 847 QVPPAPLPPA---SHPPATSTNKR---TNLKKP 873
             P  P  PA      PA +T K    T  KKP
Sbjct: 527 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 559



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 105/512 (20%), Positives = 160/512 (31%), Gaps = 81/512 (15%)

Query: 423  TVSSQPVPFSALGP----TEKPGIEIGKVPPPI------PGVGKQLPPSYGTYPSPTPLG 472
            T   +P P +   P    T+KP     K P P       P   K+L P+     +PT   
Sbjct: 538  TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 597

Query: 473  PGSTSSLERRKEGSLPRPSAGLPSRQRPTL----LPATGSTPQPGSSQQIQQRISVPPSP 528
              + ++ E     +   P+   P    PT      P T   P P + ++        P+P
Sbjct: 598  KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 657

Query: 529  TYPPAGPPAFPAGDSK----------PELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSS 578
            T P    P  P G +           P+ P    + P    + +     +  P T   ++
Sbjct: 658  TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 717

Query: 579  IYSMYLQQATPPKNYQPA-----AHSALNKSVKAVYGKPVL----------PSGSTSPSP 623
              +      T PK   P      A + L +       KP            P+ +TS  P
Sbjct: 718  PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 777

Query: 624  LPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPL 683
             P       T    P+ P+ +T K+P    P  P    T   +  P +  + T I  SP 
Sbjct: 778  APTT--PKETAPTTPKEPAPTTPKKPAPTTPETPPP--TTSEVSTPTTTKEPTTIHKSPD 833

Query: 684  RYQSDADLEALRRKLANAPR----PLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEG 739
                +   E   + L N+P+    P  K  + T+PE             +  T    +  
Sbjct: 834  ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE--------MTTTAKDKTTERDLRT 885

Query: 740  TP---FYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEP------APSSD 790
            TP      P  +++   T          A          Q T P           AP   
Sbjct: 886  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 945

Query: 791  ANDNELPSPE----PEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEE 846
                 + + E    PEE         TA+P +   N+ AT P     P    +AP     
Sbjct: 946  TTKKTITTTEIMNKPEE---------TAKPKDRATNSKATTPK----PQKPTKAPKKPTS 992

Query: 847  QVPPAPLPPASHPPATSTNKRTNLKKPNSERT 878
               P  +P    P  T T ++     P    T
Sbjct: 993  TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 1024



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 79/385 (20%), Positives = 133/385 (34%), Gaps = 53/385 (13%)

Query: 331  SSPQSPLSTSGR-VAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNW 389
            ++P+ P  T+ +  A   P    P+    P    P KP    +A       + +  D   
Sbjct: 650  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 709

Query: 390  PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSS---QPVPFSA-------LGPTEK 439
            PT  + ++ +  P + A    K+P+   +  +GT  +   +P P +        L PT  
Sbjct: 710  PTTPKGTAPTT-PKEPAPTTPKEPAP--TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 766

Query: 440  PGIEIGKVPPPIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQ 498
             G        P P   K+  P+    P+PT P  P  T+          P P+    S  
Sbjct: 767  KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP-------ETPPPTTSEVSTP 819

Query: 499  RPTLLPAT------GSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVA 552
              T  P T       STP+  +    +   + P  P  P    PA     +KPE+  T  
Sbjct: 820  TTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAK 875

Query: 553  IRPFLADKGSRPQSPRKGPQ-----------------TVNSSSIYSMYLQQATPPKNYQP 595
             +    D  + P++    P+                 T  ++ + S   Q  TP K    
Sbjct: 876  DKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTL 935

Query: 596  AAHSALNK---SVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQD 652
               +   K   + K +    ++     +  P      S +T TP+PQ P+++ +K     
Sbjct: 936  KTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT-TPKPQKPTKAPKKPTSTK 994

Query: 653  GPAAPADGSTVESLPRPLSPTKLTP 677
             P         ++ P P   T   P
Sbjct: 995  KPKTMPRVRKPKTTPTPRKMTSTMP 1019



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 53/271 (19%), Positives = 92/271 (33%), Gaps = 39/271 (14%)

Query: 615 PSGSTSPSPLPFLHGSLSTGTPQPQPPSE-STEKEPEQDGPAAPADGSTVESLPRPLSPT 673
           PS   +P P        ST    P+PP++  T+K  E +        S  +      S +
Sbjct: 73  PSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSS 132

Query: 674 KLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTL 733
             +  +      ++ A    L++KL    +  KK  +  +P  P  P + +         
Sbjct: 133 SSSSTIRKIKSSKNSAANRELQKKL--KVKDNKKNRTKKKPT-PKPPVVDE--------A 181

Query: 734 AGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDAND 793
             G++         + DF  T  D      N      ++  A+P  P P+ P  S  + +
Sbjct: 182 GSGLD---------NGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKE 232

Query: 794 NELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQI-----------------PSP 836
             L   +   +   +TT    + + D      +   T+ I                 P+P
Sbjct: 233 TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP 292

Query: 837 VAEAPSPGEE-QVPPAPLPPASHPPATSTNK 866
            AE  + G     P  P P     PA++T K
Sbjct: 293 KAETTTKGPALTTPKEPTPTTPKEPASTTPK 323


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 126/564 (22%), Positives = 193/564 (34%), Gaps = 51/564 (9%)

Query: 331 SSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWP 390
           ++P+ P  T+ + A   P    P+    P    P +P   +    A      +      P
Sbjct: 376 TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEP 435

Query: 391 T-LKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
                   +   P + A    K+P+     +    + +P P +   P      +     P
Sbjct: 436 APTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTP 495

Query: 450 --PIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTL---- 502
             P P   K+  P+    PSPT P  P  T++         P P+    ++  PT     
Sbjct: 496 KEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTT---TKSAPTTPKEP 552

Query: 503 LPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGS 562
            P T   P P + ++        P+PT P    P  P    K   P T         K  
Sbjct: 553 SPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTP----KEPAPTTTKKPAPTTPKEP 608

Query: 563 RPQSPRK-GPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSP 621
            P +P++  P T    +  +      T P+   P     L  +       P  P+ +T  
Sbjct: 609 APTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTT------PEEPTPTTPE 662

Query: 622 SPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGS---TVESLPRPLSPTKL--- 675
            P P    + +  TP+   P+ +T KEP    P  PA  +   T  + P+  +PT L   
Sbjct: 663 EPAPTTPKAAAPNTPKE--PAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEP 720

Query: 676 ---TPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNT 732
              TP   +P         E              K ++ T P+ P  P   K   +   T
Sbjct: 721 APTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA-PTTPK---EPAPT 776

Query: 733 LAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP------LPAEPA 786
              G   T   +P+P+        ++    T    +     PA PT P       P EPA
Sbjct: 777 TPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPA-PTTPKETAPTTPKEPA 835

Query: 787 PSSDANDN----ELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPS 842
           P++         E P P   E+  P TT    EP   + +   + P     P+P A   S
Sbjct: 836 PTTPKKPAPTTPETPPPTTSEVSTPTTTK---EPTTIHKSPDESTPELSAEPTPKALENS 892

Query: 843 PGEEQVPPAPLPPASHPPATSTNK 866
           P E  VP    P A+ P  T+T K
Sbjct: 893 PKEPGVPTTKTPAATKPEMTTTAK 916



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 96/453 (21%), Positives = 146/453 (32%), Gaps = 95/453 (20%)

Query: 448 PPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATG 507
           PP +   G  L    G +   TP     TS+ +  K  + P+ +   P   RP+L P + 
Sbjct: 216 PPVVDEAGSGL--DNGDFKVTTP----DTSTTQHNKVSTSPKITTAKPINPRPSLPPNSD 269

Query: 508 STPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRP-----------F 556
           ++ +  +S  + +  +V    T       +    +       T +I              
Sbjct: 270 TSKE--TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKV 327

Query: 557 LADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPS 616
           LA    + ++  KGP             ++ TP    +PA+ +    +   +   P  P 
Sbjct: 328 LAKPTPKAETTTKGPALTTP--------KEPTPTTPKEPASTTPKEPTPTTIKSAPTTPK 379

Query: 617 GSTSPSPLPFLHGSLSTGTPQPQP-----PSESTEKEPEQDGPAAPADGSTVESLPRPLS 671
                 P P    S  T   +P P     P+ +T KEP       PA  +T  +   P  
Sbjct: 380 -----EPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 434

Query: 672 PTKLTPIVHSPLRYQSDADLEALRRK--LANAPRPLKKRSSITEPEGPGGPNIQKLLYQR 729
           P   TP   +P   +  A              P P  K  + T P+ P  P   K     
Sbjct: 435 PAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA-PTAPK----- 488

Query: 730 FNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSS 789
                         +P+P+                         P +P    P EPAP++
Sbjct: 489 --------------KPAPTT------------------------PKEPAPTTPKEPAPTT 510

Query: 790 DANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVA---EAPSPGEE 846
               +     EP           T EPA        + PTT + PSP      AP+  +E
Sbjct: 511 TKEPSPTTPKEPAPTTTKSAPTTTKEPAP---TTTKSAPTTPKEPSPTTTKEPAPTTPKE 567

Query: 847 QVPPAPLPPA---SHPPATSTNKR---TNLKKP 873
             P  P  PA      PA +T K    T  KKP
Sbjct: 568 PAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 600



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 105/512 (20%), Positives = 160/512 (31%), Gaps = 81/512 (15%)

Query: 423  TVSSQPVPFSALGP----TEKPGIEIGKVPPPI------PGVGKQLPPSYGTYPSPTPLG 472
            T   +P P +   P    T+KP     K P P       P   K+L P+     +PT   
Sbjct: 579  TTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE 638

Query: 473  PGSTSSLERRKEGSLPRPSAGLPSRQRPTL----LPATGSTPQPGSSQQIQQRISVPPSP 528
              + ++ E     +   P+   P    PT      P T   P P + ++        P+P
Sbjct: 639  KPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAP 698

Query: 529  TYPPAGPPAFPAGDSK----------PELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSS 578
            T P    P  P G +           P+ P    + P    + +     +  P T   ++
Sbjct: 699  TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTA 758

Query: 579  IYSMYLQQATPPKNYQPA-----AHSALNKSVKAVYGKPVL----------PSGSTSPSP 623
              +      T PK   P      A + L +       KP            P+ +TS  P
Sbjct: 759  PTTPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKP 818

Query: 624  LPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPL 683
             P       T    P+ P+ +T K+P    P  P    T   +  P +  + T I  SP 
Sbjct: 819  APTT--PKETAPTTPKEPAPTTPKKPAPTTPETPPP--TTSEVSTPTTTKEPTTIHKSPD 874

Query: 684  RYQSDADLEALRRKLANAPR----PLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEG 739
                +   E   + L N+P+    P  K  + T+PE             +  T    +  
Sbjct: 875  ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPE--------MTTTAKDKTTERDLRT 926

Query: 740  TP---FYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEP------APSSD 790
            TP      P  +++   T          A          Q T P           AP   
Sbjct: 927  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 986

Query: 791  ANDNELPSPE----PEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEE 846
                 + + E    PEE         TA+P +   N+ AT P     P    +AP     
Sbjct: 987  TTKKTITTTEIMNKPEE---------TAKPKDRATNSKATTPK----PQKPTKAPKKPTS 1033

Query: 847  QVPPAPLPPASHPPATSTNKRTNLKKPNSERT 878
               P  +P    P  T T ++     P    T
Sbjct: 1034 TKKPKTMPRVRKPKTTPTPRKMTSTMPELNPT 1065



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 79/385 (20%), Positives = 133/385 (34%), Gaps = 53/385 (13%)

Query: 331  SSPQSPLSTSGR-VAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNW 389
            ++P+ P  T+ +  A   P    P+    P    P KP    +A       + +  D   
Sbjct: 691  TTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPA 750

Query: 390  PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSS---QPVPFSA-------LGPTEK 439
            PT  + ++ +  P + A    K+P+   +  +GT  +   +P P +        L PT  
Sbjct: 751  PTTPKGTAPTT-PKEPAPTTPKEPAP--TTPKGTAPTTLKEPAPTTPKKPAPKELAPTTT 807

Query: 440  PGIEIGKVPPPIPGVGKQLPPSYGTYPSPT-PLGPGSTSSLERRKEGSLPRPSAGLPSRQ 498
             G        P P   K+  P+    P+PT P  P  T+          P P+    S  
Sbjct: 808  KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP-------ETPPPTTSEVSTP 860

Query: 499  RPTLLPAT------GSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVA 552
              T  P T       STP+  +    +   + P  P  P    PA     +KPE+  T  
Sbjct: 861  TTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAK 916

Query: 553  IRPFLADKGSRPQSPRKGPQ-----------------TVNSSSIYSMYLQQATPPKNYQP 595
             +    D  + P++    P+                 T  ++ + S   Q  TP K    
Sbjct: 917  DKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTL 976

Query: 596  AAHSALNK---SVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQD 652
               +   K   + K +    ++     +  P      S +T TP+PQ P+++ +K     
Sbjct: 977  KTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT-TPKPQKPTKAPKKPTSTK 1035

Query: 653  GPAAPADGSTVESLPRPLSPTKLTP 677
             P         ++ P P   T   P
Sbjct: 1036 KPKTMPRVRKPKTTPTPRKMTSTMP 1060



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 53/271 (19%), Positives = 92/271 (33%), Gaps = 39/271 (14%)

Query: 615 PSGSTSPSPLPFLHGSLSTGTPQPQPPSE-STEKEPEQDGPAAPADGSTVESLPRPLSPT 673
           PS   +P P        ST    P+PP++  T+K  E +        S  +      S +
Sbjct: 114 PSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEITEEHSVSENQESSSSSSSS 173

Query: 674 KLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTL 733
             +  +      ++ A    L++KL    +  KK  +  +P  P  P + +         
Sbjct: 174 SSSSTIRKIKSSKNSAANRELQKKL--KVKDNKKNRTKKKPT-PKPPVVDE--------A 222

Query: 734 AGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDAND 793
             G++         + DF  T  D      N      ++  A+P  P P+ P  S  + +
Sbjct: 223 GSGLD---------NGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSKE 273

Query: 794 NELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQI-----------------PSP 836
             L   +   +   +TT    + + D      +   T+ I                 P+P
Sbjct: 274 TSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTP 333

Query: 837 VAEAPSPGEE-QVPPAPLPPASHPPATSTNK 866
            AE  + G     P  P P     PA++T K
Sbjct: 334 KAETTTKGPALTTPKEPTPTTPKEPASTTPK 364


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 154/591 (26%), Positives = 208/591 (35%), Gaps = 76/591 (12%)

Query: 329 GTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIAS-------NAAHGRS 381
           GT SP     +      VG     PSA   P    P K  S+S AS       + A  R 
Sbjct: 161 GTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK--SVSSASEHSTTEPSPAARRR 218

Query: 382 KSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVP--FSALGPTEK 439
            SA  G      ++ SSS  P+         PS  G+ +     SQP P    AL P + 
Sbjct: 219 PSAGGGLQRPASRSLSSSATPLSSPARS--GPSARGTPRAPAHPSQPKPKGLQALRPPQ- 275

Query: 440 PGIEIGKVPPPIPGVGKQLPP-SYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQ 498
                  V PP       L P S     +P+P  P S S+    +  +LP P A  PS+ 
Sbjct: 276 -------VTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQ--TLPSPPATPPSQA 326

Query: 499 R-----PTL------LPATGSTPQPGSSQQIQQRISVPP--SPTYPPAGPPAFPAGDSKP 545
                 PTL      LP+   +P      Q    +++PP  +P  PPA PP  P     P
Sbjct: 327 TTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSP 386

Query: 546 ELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPA-AHSALNKS 604
           + P  +A+    A     P  P + P +  +S   S     ATPP    P+ A   L   
Sbjct: 387 QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS---PSATPPSQAPPSLAAPPLQVP 443

Query: 605 VKAVYGKPVLPSGSTSP-SPLPFLHGSLSTGTPQPQ-PPSESTEKEPEQDGPAAPADGST 662
                  P+ PS +  P +P P     L    P PQ PP+ +T   P Q  P+ PA    
Sbjct: 444 PSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALAT--PPLQALPSPPA---- 497

Query: 663 VESLP--RPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGP 720
             S P   P SP+   P+  SPL          L   L   P       ++  P  P  P
Sbjct: 498 --SFPGQAPFSPSASLPM--SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTP 553

Query: 721 NIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELP--PAQPT 778
                +     TLA      P    SPS    G   D+   +++A    EEL    + P 
Sbjct: 554 GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSG--PDLAGHSSSATSTPEELRGYDSGPE 611

Query: 779 APLPAEPAPSSDANDNELPSPEPEELI---CPQTTHQTAE------PAEDNNNNVATVPT 829
               A P P     D EL +  P        P    + A       P      +   + T
Sbjct: 612 GGAAASPPP-----DAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCT 666

Query: 830 TEQIPSPVAEAPSPGEEQVPPAPLPPAS-HPPATSTNKRTNLKKPNSERTG 879
             +   P +  P+PG   + P P P  S    A       + + P   R G
Sbjct: 667 IYETEGPESATPAPG--ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLG 715



 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 125/515 (24%), Positives = 193/515 (37%), Gaps = 83/515 (16%)

Query: 398 SSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSA--LGPTEKPGIEIGKVPPPIPGVG 455
           ++++ +  AGA  + P  E   + G +    +P SA   GPT           PP  G G
Sbjct: 42  AALRVLGAAGAVGRKPLAE---RAGGIGGATIPESAPRAGPTRTSR-------PPASGRG 91

Query: 456 KQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSS 515
           ++ PP+  T P P    PG  S   R   G L +    + + +      AT +  +   S
Sbjct: 92  ERAPPAKNTSPGPVS-SPGRASGTTR--PGPLGQKGLRISAEETVARGKATEAPKRSALS 148

Query: 516 QQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGP-QTV 574
              ++  S P   T  PA      A  ++  LP     RP      +RP+ P +GP ++V
Sbjct: 149 AGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP-----RP---APSARPRPPTEGPRKSV 200

Query: 575 NSSSIYSMYLQQATPPKNYQPAAHSALN------------------KSVKAVYGKPVLPS 616
           +S+S +S    + +P    +P+A   L                   +S  +  G P  P+
Sbjct: 201 SSASEHS--TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPA 258

Query: 617 GSTSPSPLPFLHGSLSTGTPQPQPP-----------SESTEKEPEQDGPAAPADGSTVES 665
             + P P     G  +   PQ  PP           S S    P    P +P+   ++++
Sbjct: 259 HPSQPKP----KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQT 314

Query: 666 LPRP--LSPTKLTPIVHSPL-----RYQSDADLEALRRKLANAPRPLKKRSSITEPEGPG 718
           LP P    P++ T  + SP       +     L  L      AP  L        P  P 
Sbjct: 315 LPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA 374

Query: 719 GPNIQKLLY---QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGN-LEELPP 774
            P +  L     Q  N LA  +   PF  P PS       +   +   + +     + PP
Sbjct: 375 SPPLSPLATPSPQAPNALAVHLLQAPF-SPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433

Query: 775 AQPTAPLPAEPAP--SSDANDNELPSPE-PEELICPQTTHQTAEPAEDNNNNVATVPTTE 831
           +    PL   P+P  S   + +  P P+ P  L  P    Q A+P       +AT P  +
Sbjct: 434 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPL--QLAKPPPQAPPALAT-PPLQ 490

Query: 832 QIPSPVA----EAPSPGEEQVPPAPL--PPASHPP 860
            +PSP A    +AP      +P +PL  PP   PP
Sbjct: 491 ALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPP 525


>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
           16A [Homo sapiens]
          Length = 528

 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 44/129 (34%), Positives = 71/129 (55%), Gaps = 3/129 (2%)

Query: 871 KKPNSERTGHGL--RVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNA 928
           ++P  E    GL  +V F P  +LL+A+   + + V++ +     P   N++G+T LH  
Sbjct: 52  ERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLEEVRQFLGSGVSPDLANEDGLTALHQC 111

Query: 929 VCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDI 988
                  +V+ LL+ G N+NA DS+ WTPLH AA+C  +HL + L+ SGA + A   +D 
Sbjct: 112 CIDDFREMVQQLLEAGANINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVN-TDG 170

Query: 989 ETAADKCEE 997
               D C++
Sbjct: 171 NMPYDLCDD 179



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 34/87 (39%), Positives = 43/87 (49%), Gaps = 1/87 (1%)

Query: 913 DPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQ 972
           D   P D G T LH A   G       LL+   +++A D DGW PLH AA    V L + 
Sbjct: 224 DLHAPLDHGATLLHVAAANGFSEAAALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVEL 283

Query: 973 LVESGAAIFASTISDIETAADKCEEME 999
           LV  GA + A ++ D ET  D C + E
Sbjct: 284 LVAHGADLNAKSLMD-ETPLDVCGDEE 309


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 132/551 (23%), Positives = 192/551 (34%), Gaps = 75/551 (13%)

Query: 330 TSSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSL-SIASNAAHGRSKSANDGN 388
           ++ P SP   +       P +Q   + +   L  P+    L +++S A+H      +   
Sbjct: 449 STPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLI 508

Query: 389 WPTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPF-SALGPTEKPGIEIGKV 447
            P L+  SS +   +Q   A    P +E        S  P P  +A  P   P +E    
Sbjct: 509 MPPLETQSSLAPPSLQTPPASLTTPPLEN-----LPSLAPPPLQTASAPLTTPHLETPPC 563

Query: 448 PPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSA-GLPSRQRPTLLPAT 506
           P P P    Q PPS  T P P    P S ++   +   +L  P   GLPS   P L P  
Sbjct: 564 PAPCP---LQAPPSPLTTPPPET--PSSIATPPPQAPPALASPPLQGLPS---PPLSPL- 614

Query: 507 GSTPQPGSSQQIQQRISVPP--SPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRP 564
            +TP P    Q    +++PP  +P  PPA PP  P     P+ P  +A+    A     P
Sbjct: 615 -ATPPP----QAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 669

Query: 565 QSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPL 624
             P + P +  +S   S     ATPP    P+          A     V PS   SP   
Sbjct: 670 SPPVQAPFSPPASPPVS---PSATPPSQAPPSL---------AAPPLQVPPSPPASPPMS 717

Query: 625 PFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLR 684
           P      +T  PQ  PP  +   +     PA+P           P+SP+   P    PL 
Sbjct: 718 P-----SATPPPQAPPPLAAPPLQVPPSPPASP-----------PMSPSATPPPRVPPL- 760

Query: 685 YQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQ 744
                 L A   ++  +P      S + +P     P +     Q   +      G   + 
Sbjct: 761 ------LAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS 814

Query: 745 PSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPL------PAEPAPSSDANDNEL-- 796
           PS S                    L ++PP+ P +P       P  P P +  +   L  
Sbjct: 815 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTL 874

Query: 797 ---PSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPL 853
              P P P     P +T    + A  +++  +T        S     P  G    PP   
Sbjct: 875 ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS----GPEGGAAASPPPDA 930

Query: 854 P-PASHPPATS 863
              A HP A S
Sbjct: 931 ELAACHPAAWS 941



 Score = 74.7 bits (182), Expect = 4e-13
 Identities = 119/493 (24%), Positives = 176/493 (35%), Gaps = 41/493 (8%)

Query: 428 PVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSL 487
           P+P +   P+  P ++    PP  P    Q PPS  T P   P  P   +    +   SL
Sbjct: 340 PLPLAPPSPSAPPSLQTLPSPPATPP--SQAPPSMTTPPMQAP--PSLQTIPPIQVPHSL 395

Query: 488 PRPSAGLPSRQRPTLLPATGSTPQPGSS--QQIQQRISVPPSPTYPPAGPPAFPAG---D 542
             PS   P    P  L +  +T   GS   Q     +++ P  T      P+ PA    D
Sbjct: 396 TSPSLQAPPS--PLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPD 453

Query: 543 SKP-ELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQAT---------PPKN 592
           S P + PL++   P L    S   SP   P T++     S     +          PP  
Sbjct: 454 SPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLE 513

Query: 593 YQPA-AHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQP-PSESTEKEPE 650
            Q + A  +L     ++   P+    S +P PL      L+T   +  P P+    + P 
Sbjct: 514 TQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPP 573

Query: 651 QDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSS 710
                 P +  +  + P P +P  L      PL+      L  L      AP  L     
Sbjct: 574 SPLTTPPPETPSSIATPPPQAPPALAS---PPLQGLPSPPLSPLATPPPQAPPXLALPPL 630

Query: 711 ITEPEGPGGPNIQKLLY---QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANG 767
              P  P  P +  L     Q  N LA  +   PF  P PS       +   +   + + 
Sbjct: 631 QAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPF-SPPPSPPVQAPFSPPASPPVSPSA 689

Query: 768 NL-EELPPAQPTAPLPAEPAP--SSDANDNELPSPE-PEELICPQTTHQTAEPAEDNNNN 823
               + PP+    PL   P+P  S   + +  P P+ P  L  P      + PA    + 
Sbjct: 690 TPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSP 749

Query: 824 VATVP--TTEQIPSPVAEAPSPGEEQVPPAPL--PPASHPPATSTNKRTNLKKPNSERTG 879
            AT P      + +P  + P      +P +PL  PP   PPA +T     L  P +   G
Sbjct: 750 SATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPG 809

Query: 880 HGLRVRFNPLALL 892
              +  F+P A L
Sbjct: 810 ---QAPFSPSASL 819



 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 125/490 (25%), Positives = 185/490 (37%), Gaps = 83/490 (16%)

Query: 398 SSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSA--LGPTEKPGIEIGKVP--PPIPG 453
           ++++ +  AGA  + P  E   + G +    +P SA   GPT   G         PP  G
Sbjct: 42  AALRVLGAAGAVGRKPLAE---RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASG 98

Query: 454 VGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPG 513
            G++ PP+  T P P    PG  S   R   G L +    + + +      AT +  +  
Sbjct: 99  RGERAPPAKNTSPGPVS-SPGRASGTTR--PGPLGQKGLRISAEETVARGKATEAPKRSA 155

Query: 514 SSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGP-Q 572
            S   ++  S P   T  PA      A  ++  LP     RP      +RP+ P +GP +
Sbjct: 156 LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP-----RP---APSARPRPPTEGPRK 207

Query: 573 TVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPL--PFLHGS 630
           +V+S+S +S    + +P    +P+A   L         +P   S S+S +PL  P   G 
Sbjct: 208 SVSSASEHS--TTEPSPAARRRPSAGGGLQ--------RPASRSLSSSATPLSSPARSGP 257

Query: 631 LSTGTP-------QPQPPSESTEKEPEQDGP---AAPADG---STVESLPRPLSPTKLTP 677
            + GTP       QP+P      + P+   P   AAPA G   S+  + P P S TK  P
Sbjct: 258 SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP-SGTKARP 316

Query: 678 IVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGM 737
           +         D     L   L  +P PL     +  P     P++Q L            
Sbjct: 317 VP------PPDNAATPLPATLPPSP-PLATPLPLAPPSPSAPPSLQTL---------PSP 360

Query: 738 EGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELP 797
             TP  Q  PS         +      A  +L+ +PP Q          P S  + +   
Sbjct: 361 PATPPSQAPPS---------MTTPPMQAPPSLQTIPPIQ---------VPHSLTSPSLQA 402

Query: 798 SPEPEELICPQTTHQTAEPAEDNNNNVATV---PTTEQIPSPVAEAPSPGEEQVPPAPLP 854
            P P  L   Q T     P     ++  T+    T   + SP   A +P +     APL 
Sbjct: 403 PPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLS 462

Query: 855 -PASHPPATS 863
            PAS P  TS
Sbjct: 463 LPASPPLQTS 472



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 47/191 (24%), Positives = 68/191 (35%), Gaps = 24/191 (12%)

Query: 331 SSPQSPLSTSGRVAA---VGPYIQVP-SAGSFPVLGDPIKPQSLSIASNAAHGRSKSA-N 385
           S P SPL+T    A      P +QVP S  + P L  P +P +    ++ +  R   A  
Sbjct: 818 SLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALA 877

Query: 386 DGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVK------QGTVSSQPVPFSALGPTEK 439
            G  P   ++ SS++    +AG      S    ++      +G  ++ P P + L     
Sbjct: 878 PGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHP 937

Query: 440 PGIEIGKVPP----PIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLP 495
                G  PP      PG     PP+          GPGS   L    E   P  +   P
Sbjct: 938 AAWSRGPAPPLAFRGAPGAPLPWPPA---------TGPGSADGLCTIYETEGPESATPAP 988

Query: 496 SRQRPTLLPAT 506
               P   P T
Sbjct: 989 GALDPGPSPGT 999



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 32/147 (21%), Positives = 48/147 (32%), Gaps = 12/147 (8%)

Query: 734 AGGMEGTPFYQPSPSQD---FMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSD 790
           AGG+ G    + +P        GT +        A+G  E  PPA+ T+P P      + 
Sbjct: 62  AGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRAS 121

Query: 791 ANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSP------- 843
                 P  +    I  + T    +  E    +  +         P    PSP       
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181

Query: 844 --GEEQVPPAPLPPASHPPATSTNKRT 868
             G E   P P P A   P T   +++
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKS 208


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 156/616 (25%), Positives = 211/616 (34%), Gaps = 96/616 (15%)

Query: 329 GTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIAS-------NAAHGRS 381
           GT SP     +      VG     PSA   P    P K  S+S AS       + A  R 
Sbjct: 170 GTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRK--SVSSASEHSTTEPSPAARRR 227

Query: 382 KSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFS--------- 432
            SA  G      ++ SSS  P+         PS  G+ +     SQP P           
Sbjct: 228 PSAGGGLQRPASRSLSSSATPLSSPARS--GPSARGTPRAPAHPSQPKPKGLQALRPPQV 285

Query: 433 ---------ALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYP----------SPTPLGP 473
                    ALGP     +     P P   +  Q PP+    P          +P PL P
Sbjct: 286 TPPRKDAAPALGPLSSSPLA---TPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP 342

Query: 474 GSTSSLERRKEGSLPRPSAGLPSRQR-----PTL------LPATGSTPQPGSSQQIQQRI 522
            S S+    +  +LP P A  PS+       PTL      LP+   +P      Q    +
Sbjct: 343 PSPSAPPSLQ--TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL 400

Query: 523 SVPP--SPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIY 580
           ++PP  +P  PPA PP  P     P+ P  +A+    A     P  P + P +  +S   
Sbjct: 401 ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPV 460

Query: 581 SMYLQQATPPKNYQPA-AHSALNKSVKAVYGKPVLPSGSTSP-SPLPFLHGSLSTGTPQP 638
           S     ATPP    P+ A   L          P+ PS +  P +P P     L    P P
Sbjct: 461 S---PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPP 517

Query: 639 Q-PPSESTEKEPEQDGPAAPADGSTVESLP--RPLSPTKLTPIVHSPLRYQSDADLEALR 695
           Q PP+ +T   P Q  P+ PA      S P   P SP+   P+  SPL          L 
Sbjct: 518 QAPPALAT--PPLQALPSPPA------SFPGQAPFSPSASLPM--SPLATPPPQAPPVLA 567

Query: 696 RKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTL 755
             L   P       ++  P  P  P     +     TLA      P    SPS    G  
Sbjct: 568 APLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSG-- 625

Query: 756 ADVDNGNTNANGNLEELP--PAQPTAPLPAEPAPSSDANDNELPSPEPEELI---CPQTT 810
            D+   +++A    EEL    + P     A P P     D EL +  P        P   
Sbjct: 626 PDLAGHSSSATSTPEELRGYDSGPEGGAAASPPP-----DAELAACHPAAWSRGPAPPLA 680

Query: 811 HQTAE------PAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPAS-HPPATS 863
            + A       P      +   + T  +   P +  P+PG   + P P P  S    A  
Sbjct: 681 FRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG--ALDPGPSPGTSGGKAAAG 738

Query: 864 TNKRTNLKKPNSERTG 879
                + + P   R G
Sbjct: 739 AGAGASSRSPKQARLG 754



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 126/495 (25%), Positives = 188/495 (37%), Gaps = 83/495 (16%)

Query: 398 SSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSA--LGPTEKPGIEIGKVP--PPIPG 453
           ++++ +  AGA  + P  E   + G +    +P SA   GPT   G         PP  G
Sbjct: 42  AALRVLGAAGAVGRKPLAE---RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASG 98

Query: 454 VGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPG 513
            G++ PP+  T P P    PG  S   R   G L +    + + +      AT +  +  
Sbjct: 99  RGERAPPAKNTSPGPVS-SPGRASGTTR--PGPLGQKGLRISAEETVARGKATEAPKRSA 155

Query: 514 SSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGP-Q 572
            S   ++  S P   T  PA      A  ++  LP     RP      +RP+ P +GP +
Sbjct: 156 LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP-----RP---APSARPRPPTEGPRK 207

Query: 573 TVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPL--PFLHGS 630
           +V+S+S +S    + +P    +P+A   L         +P   S S+S +PL  P   G 
Sbjct: 208 SVSSASEHS--TTEPSPAARRRPSAGGGLQ--------RPASRSLSSSATPLSSPARSGP 257

Query: 631 LSTGTP-------QPQPPSESTEKEPEQDGP---AAPADGSTVESLPRPLSPTKL-TPIV 679
            + GTP       QP+P      + P+   P   AAPA G        PLS + L TP  
Sbjct: 258 SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG--------PLSSSPLATPSP 309

Query: 680 HSPLRYQSDADLEA------LRRKLAN-----APRPLKKRSSITEPEGPGGPNIQKLLYQ 728
            + L+ Q+   L A      L  +LA       P P    S  T P  P  P  Q     
Sbjct: 310 SAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSL 369

Query: 729 RFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPS 788
              TL    + T  + PSP    + T                + PPA    PL A P+P 
Sbjct: 370 GSPTL----QATHSFLPSPPLSPLATPP-------------PQAPPALALPPLQAPPSPP 412

Query: 789 SDANDNELPSPEPEELICPQ--TTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEE 846
           +    + L +P P+    P     H    P     +     P +     PV+ + +P  +
Sbjct: 413 ASPPLSPLATPSPQ---APNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 469

Query: 847 QVPPAPLPPASHPPA 861
             P    PP   PP+
Sbjct: 470 APPSLAAPPLQVPPS 484



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 32/147 (21%), Positives = 48/147 (32%), Gaps = 12/147 (8%)

Query: 734 AGGMEGTPFYQPSPSQD---FMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSD 790
           AGG+ G    + +P        GT +        A+G  E  PPA+ T+P P      + 
Sbjct: 62  AGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRAS 121

Query: 791 ANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSP------- 843
                 P  +    I  + T    +  E    +  +         P    PSP       
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181

Query: 844 --GEEQVPPAPLPPASHPPATSTNKRT 868
             G E   P P P A   P T   +++
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKS 208


>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
           [Homo sapiens]
          Length = 567

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 46/119 (38%), Positives = 63/119 (52%), Gaps = 1/119 (0%)

Query: 879 GHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVK 938
           G   +V F     LL+ASL  + + V+  +     P   N++G+T LH         IVK
Sbjct: 59  GRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVK 118

Query: 939 FLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEE 997
            LL  G NVNA D++ WTPLH AA+C  ++L K LV+ GA + A   SD     D CE+
Sbjct: 119 LLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVN-SDGNMPYDLCED 176



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 34/80 (42%), Positives = 43/80 (53%), Gaps = 1/80 (1%)

Query: 920 EGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAA 979
           +G T LH A   G+    + LLD GV V+  D DGW PLH AA    + + + LV  GA+
Sbjct: 228 QGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGAS 287

Query: 980 IFASTISDIETAADKCEEME 999
           + A T  D E   D CEE E
Sbjct: 288 LSARTSMD-EMPIDLCEEEE 306


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 138/540 (25%), Positives = 190/540 (35%), Gaps = 94/540 (17%)

Query: 413  PSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPP--IPGVGKQLPPS-YGTYPSPT 469
            PS +G +        P   +A  P+ K G+     PPP   P      PPS  G   +P+
Sbjct: 1134 PSPKGGLATPPPKGAPTTPAATPPSPKGGLA---TPPPKGAPTTPAATPPSPKGGLATPS 1190

Query: 470  PLG-PGSTSSLERRKEGSLPRPSA-GLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPS 527
            P G P + ++     +G L  PS  G P+    T     G    P          + PPS
Sbjct: 1191 PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPS 1250

Query: 528  P-----TYPPAGPPAFPAGDSKPELPLTVAIRPFL-----------ADKGSRPQSPRKGP 571
            P     T PP G P  PA  + P L   +A  P             + KG    SP KG 
Sbjct: 1251 PKGGPATPPPKGAPTPPAA-TPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGA 1309

Query: 572  QTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSL 631
             T  +++  S      TPP    P   +    S K   G P LP+ + S    P    S 
Sbjct: 1310 PTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPK---GTPTLPATTPSSKGGPTTPSSK 1366

Query: 632  STGTPQPQPPSES-----TEKEPEQDGPAAPAD-GSTVESLPRPLSPTKL--TPIVHSPL 683
               TP    PS       T   P++ GPA P+  G        PLSP K   TP+     
Sbjct: 1367 EGPTPPAATPSHKGGPAMTPPSPKR-GPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGA 1425

Query: 684  RYQSDADLEALRRKLANAPRPLKKRSSITEPEG-PGGPNIQKLLYQRFNTLAGGMEGTPF 742
               S  DL       A  P  LKK  + + P+G P  P+ +        TL      +P 
Sbjct: 1426 ATPSKGDLTPP----AVTPVSLKKAPATSAPKGGPATPSSKG-----DPTLPAVTPPSPK 1476

Query: 743  YQPSPSQDFMGTLADVDNGNTNANG----------NLEELP--------PAQPTAPLPAE 784
              P+P Q    +            G          + +E+P        P  PTA L ++
Sbjct: 1477 EPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSK 1536

Query: 785  PAPSSDANDNEL-------PSPEPEELI-CPQTTHQTAEPAEDNNNNVATVPTTEQIPSP 836
              P++ A    L       PSP+    I  P+    T    E ++    T  T +  PSP
Sbjct: 1537 KTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSP 1596

Query: 837  -------VAEAPSPGEEQVPPAPLPP--------------ASHPPATSTNKRTNLKKPNS 875
                      +PSP E   PPA  PP               + PP T ++ + +   P S
Sbjct: 1597 KELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPAS 1656



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 138/562 (24%), Positives = 182/562 (32%), Gaps = 84/562 (14%)

Query: 331  SSPQS-PLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNW 389
            SSP+  P   SG  A         S G+   L D   P  +S++       +K  + G  
Sbjct: 765  SSPKECPTEDSGASATAS------SKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGP- 817

Query: 390  PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
             T   N SS V PV+ +       S +GS      +  P P S  G      +       
Sbjct: 818  DTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVT------ 871

Query: 450  PIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGST 509
            P+   G  LPP      +PTP    S  +L   KEG         P+ ++   L  T S+
Sbjct: 872  PLSPKGVTLPPK----ETPTP----SVVNLPFPKEGP------ATPAPKQAPALSMTSSS 917

Query: 510  PQPGSSQQIQQRISVPPSPTY---PPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQS 566
            P+   +    + I   PSP     PPA  P  P G      P      P      + P S
Sbjct: 918  PKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPP-----AATPPS 972

Query: 567  PRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSA-LNKSVKAVYGKPVL--PSGSTSPSP 623
            P+ GP T +            TPP    P+        S K     P +  PS   SP+ 
Sbjct: 973  PKGGPATPSPKG-------APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAA 1025

Query: 624  LPFLHGSLSTGTPQPQPPSESTEKEPEQDG----PAA----PADGSTVESLPRPLSPTKL 675
             PF  G+ +     P  P  S    P   G    PAA    P  G    SL    +P   
Sbjct: 1026 TPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAA 1085

Query: 676  TPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQR-----F 730
            TP    P      A        +  A  P   +  +  P   G P               
Sbjct: 1086 TP----PSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLA 1141

Query: 731  NTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNA-------NGNLEELPPAQPTAPLPA 783
                 G   TP   P   +  + T        T A        G     P   PT P   
Sbjct: 1142 TPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT 1201

Query: 784  EPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSP 843
             P+P        L +P P+      TT     P+      +AT        +P A  PSP
Sbjct: 1202 PPSPKGG-----LATPSPKG---APTTPAATPPSP--KGGLATPSPKGAPTTPAATPPSP 1251

Query: 844  -GEEQVPP---APLPPASHPPA 861
             G    PP   AP PPA+ PP+
Sbjct: 1252 KGGPATPPPKGAPTPPAATPPS 1273



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 126/502 (25%), Positives = 181/502 (36%), Gaps = 79/502 (15%)

Query: 413  PSVEGSVKQGTVSSQPVPFSALGPTEK-----PGIEIGKVPP----PIPGVGKQLPPSYG 463
            PS +G     ++   P P +A  P+ K     P  +   +PP    P P  G   PP  G
Sbjct: 1065 PSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKG 1124

Query: 464  --TYPSPTPLGPGSTSSLERRK------EGSLPRPSAGL---PSRQRPTLLPATGSTPQP 512
              T P+ TP  P    +    K        + P P  GL   P +  PT   AT  +P+ 
Sbjct: 1125 APTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG 1184

Query: 513  GSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPE---LPLTVAIRPFLADKGSRPQSPRK 569
            G +       S   +PT P A PP+   G + P     P T A  P     G    SP K
Sbjct: 1185 GLATP-----SPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSP-K 1238

Query: 570  GPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVL-----PSGSTSPSPL 624
            G  T  +++  S     ATPP    P   +A   S+K     P       P+  T PSP 
Sbjct: 1239 GAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSP- 1297

Query: 625  PFLHGSLSTGTPQPQP-PSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPL 683
                G  +T  P+  P P  +T   P+      P  G+       P SP K TP +    
Sbjct: 1298 ---KGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSP-KGTPTLP--- 1350

Query: 684  RYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFY 743
                           A  P      ++ +  EGP  P           +  GG   TP  
Sbjct: 1351 ---------------ATTPSSKGGPTTPSSKEGPTPPAATP-------SHKGGPAMTP-- 1386

Query: 744  QPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEE 803
             PSP +   G       G+  +   +   P   P  P+  E A +    D   P+  P  
Sbjct: 1387 -PSPKR---GPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVS 1442

Query: 804  LI-CPQTTHQTAEPAEDNNNN-----VATVPTTEQIPSP--VAEAPSPGEEQVPPAPLPP 855
            L   P T+     PA  ++         T P+ ++ P+P  VA + SP +    PAP+  
Sbjct: 1443 LKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA 1502

Query: 856  ASHPPATSTNKRTNLKKPNSER 877
             + P    ++ +     P+S R
Sbjct: 1503 PTLPAVIPSSPKEVPATPSSRR 1524



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 142/596 (23%), Positives = 202/596 (33%), Gaps = 103/596 (17%)

Query: 337  LSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNS 396
            L+T     A  P +  P +   P  G    P   +    AA   S   + G  P     +
Sbjct: 1278 LATPPHKGAPNPAVVTPPS---PKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPT 1334

Query: 397  SSSVKPVQVAGADW---KDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPG 453
              +V P    G        PS +G     +    P P +A  P+ K G     + PP P 
Sbjct: 1335 PPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAAT-PSHKGG---PAMTPPSPK 1390

Query: 454  VGKQLPPSYG--TYPSPTPLGPGSTSSLERRKEGSLPRPSAG--LPSRQRPTLL---PAT 506
             G  +P   G  T P+  PL P    +    +EG+   PS G   P    P  L   PAT
Sbjct: 1391 RGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAAT-PSKGDLTPPAVTPVSLKKAPAT 1449

Query: 507  ----GSTPQPGSSQQIQQRISVPPSPTYPPAGP-----------PAFPAGDSKPELPLTV 551
                G    P S          PPSP  PPA             PA PA    P LP  +
Sbjct: 1450 SAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVI 1509

Query: 552  AIRPFLADKGSRPQSPRKGPQTVNSS----SIYSMYLQQATP----PKN--YQPAAHSAL 601
                        P SP++ P T +S     +  +  L + TP    PK     PA     
Sbjct: 1510 ------------PSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPS 1557

Query: 602  NKSVKAV---YGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQ----PPSESTEKEPE---- 650
             K   A+      P  PS   + SP P +  S   G P P+    PP+ ++    E    
Sbjct: 1558 PKKTPAIPTPKEAPATPSSKEASSP-PAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTP 1616

Query: 651  --------QDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAP 702
                    + GPA PA   T  S P   S  K +P   + +  +  A +    + L    
Sbjct: 1617 PAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKK 1676

Query: 703  RPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFY-QPSPSQDFMGTLADV--- 758
             P   +  +  P     P I     +   T        P    PS      G L+ V   
Sbjct: 1677 GPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPA 1736

Query: 759  ------DNGNTNANGNLEELPPAQPTAPLPAEPAP--SSDANDNELPSPEPEELICPQTT 810
                   + +  A G      P  P AP  ++ +   ++ A +  LP PE   +    + 
Sbjct: 1737 PLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSP 1796

Query: 811  HQTAEPAEDNNNNVATVPTTEQI----PSPVAEAPS----PGEEQ-----VPPAPL 853
              +   A    + V T+P  +Q     P  V E+PS    P +E      +PP P+
Sbjct: 1797 PVSLPLAP---SPVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPI 1849



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 92/367 (25%), Positives = 133/367 (36%), Gaps = 78/367 (21%)

Query: 332  SPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPT 391
            S ++P + + + A + P + VPS    P +  P +  +                    P+
Sbjct: 1535 SKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPAT-------------------PS 1575

Query: 392  LKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQP--VPFSALGPTEKPGIEIGKVPP 449
             K+ SS               P+V  S  +G  S +   +P +   P+ K       V P
Sbjct: 1576 SKEASSP--------------PAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTP 1621

Query: 450  PIPGVGKQLPPSYGTYPSP--TPLG----PGSTSSLERRKEGSLPRPSAGLPSRQRPTLL 503
            P P  G   P   GT  SP  TP      P S +S+  +   ++P+ S GLP+++ PT L
Sbjct: 1622 PSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTAL 1681

Query: 504  PATGSTPQPGSSQQIQQRISVPP-----SPTYPPAGPPAFPAGDSKPELPLTVAIRPFL- 557
                  P P S+  I       P     S T PP  P       SK  L  TVA  P L 
Sbjct: 1682 KEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKGPLS-TVAPAPLLP 1740

Query: 558  -----------ADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVK 606
                        D    P+ P   P++  S+ + +   ++  P            + SV 
Sbjct: 1741 VQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPE---------SASVS 1791

Query: 607  AVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESL 666
            A    PV  S   +PSP+P L          P    ES  K      P APAD   +  L
Sbjct: 1792 AAPSPPV--SLPLAPSPVPTLPPKQQFLPSSPGLVLESPSK------PLAPADEDELLPL 1843

Query: 667  --PRPLS 671
              P P+S
Sbjct: 1844 IPPEPIS 1850



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 137/582 (23%), Positives = 206/582 (35%), Gaps = 141/582 (24%)

Query: 332 SPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPT 391
           SPQ+P    G ++  GP +  P+A S      P+   S   A          +   +   
Sbjct: 257 SPQNP----GSLSLKGP-VSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAP 311

Query: 392 LKQNSSSSVKPV-QVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPP 450
           L Q+S  SV+ + Q   +   DP+V+      T+S       A  P+++       V PP
Sbjct: 312 LHQSSFGSVQLLGQTGPSALSDPTVK------TISVDHSSTGASYPSQR------SVIPP 359

Query: 451 IPGVGKQLPPSYGTYPSPTPL---GPGSTSSLERRKEGSL---------PRPSAGLPSRQ 498
           +P   + +P +   +P   P    GP + SS+     GSL         P  S  L S  
Sbjct: 360 LPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSP 419

Query: 499 RPTL---------LPATGSTPQPGSSQQIQQRISVPPSPTYPPA---GPP--AFPAGDSK 544
             T          + + G+TP   ++      I+  P+ T+  A    PP  + P  + +
Sbjct: 420 NATYHYPLVAQMPVSSVGTTPLVVTNPCT---IAAAPTTTFEVATCVSPPMSSGPISNIE 476

Query: 545 PELPLTVAIRPFLADKGSR--------PQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPA 596
           P  P  + + P    + S         P SP   P   +  ++ S  L +    K+ Q  
Sbjct: 477 PTSPAALVMAPVAPKEPSTQVATTLRIPVSPPL-PDPEDLKNLPSSVLVKFPTQKDLQTV 535

Query: 597 AHSALNKSVKAVYGKPVLPS--GSTS---PSPLPFLHGSLSTGTPQPQPPSESTEKEPEQ 651
             S        + G P  P+  G T+   P+ LP +  +     P+  P  +ST   PE 
Sbjct: 536 PAS--------LEGAPFSPAQAGLTTKKDPTVLPLVQAA-----PKNSPSFQSTSSSPEI 582

Query: 652 DGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLA-NAPRPLKKRSS 710
             P +P      +SL  PL   K    + SPL   S A +         ++  PL K S 
Sbjct: 583 --PLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSL 640

Query: 711 IT--------EPEGPGG--PNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDN 760
           IT        E   P G  P   K              GT  Y  + S    GT++    
Sbjct: 641 ITPTVAAFPLESADPAGVAPTTAK--------------GTSTYTTTASPFLEGTVSLAPK 686

Query: 761 GNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDN 820
            +    G L  LP   PTA            ++N   +P P+    P             
Sbjct: 687 NHPVKEGTLTTLPLV-PTA------------SENCPVAPSPQNTCAP------------- 720

Query: 821 NNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPAT 862
              +AT+    +IP  V   PSP         LPPA  PP T
Sbjct: 721 ---LATLVLAPEIPKSV---PSPS--------LPPAGTPPGT 748



 Score = 37.0 bits (84), Expect = 0.10
 Identities = 49/216 (22%), Positives = 78/216 (36%), Gaps = 48/216 (22%)

Query: 473 PGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPP 532
           PG  +      E  LP+P A        + L  T +  QPG              PT PP
Sbjct: 2   PGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPG--------------PTLPP 47

Query: 533 AGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATP--- 589
                 P   +  + PL+ A             SP   P T+ S+ +   + Q ++    
Sbjct: 48  ------PCSPAPQQCPLSAA----------NQASPFPSPSTIASTPLEVPFPQSSSGTAL 91

Query: 590 PKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPL--PFLHGSLSTGTP------QPQPP 641
           P    P A + L   +    G P+ P+     SP+  P L G+ S+  P       P   
Sbjct: 92  PLGTAPEAPTFLPNLI----GPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSV 147

Query: 642 SESTEKEPE---QDGPAAPADGSTVESLPRPLSPTK 674
            +S+   P         A A+  +V +L  P++P++
Sbjct: 148 QKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSE 183



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 25/94 (26%), Positives = 37/94 (39%), Gaps = 14/94 (14%)

Query: 781 LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEA 840
           +P E   +  A + ELP P+ E  + P              ++  +V      P P    
Sbjct: 1   MPGEATETVPATEQELPQPQAETAVLPM-------------SSALSVTAALGQPGPTLPP 47

Query: 841 P-SPGEEQVPPAPLPPASHPPATSTNKRTNLKKP 873
           P SP  +Q P +    AS  P+ ST   T L+ P
Sbjct: 48  PCSPAPQQCPLSAANQASPFPSPSTIASTPLEVP 81



 Score = 30.4 bits (67), Expect = 9.5
 Identities = 59/233 (25%), Positives = 87/233 (37%), Gaps = 44/233 (18%)

Query: 413 PSVEGSVKQGTVSSQPVPFS-ALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPL 471
           P+ E  + Q    +  +P S AL  T   G     +PPP     +Q P S     SP P 
Sbjct: 10  PATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFP- 68

Query: 472 GPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYP 531
            P + +S     E   P+ S+G       T LP                  + P +PT+ 
Sbjct: 69  SPSTIASTP--LEVPFPQSSSG-------TALPLG----------------TAPEAPTFL 103

Query: 532 P--AGPPAFPAGDSKPELPLTVAIRPFLAD--KGSRPQSPRKGPQTVNSSSIYSMYLQQA 587
           P   GPP  PA        L +A  P +A   KG+   S    P  + + + +S+    A
Sbjct: 104 PNLIGPPISPAA-------LALA-SPMIAPTLKGTPSSS---APLALVALAPHSVQKSSA 152

Query: 588 TPPKNYQPAAHSALNKSVKAV-YGKPVLPS-GSTSPSPLPFLHGSLSTGTPQP 638
            PP         A+ +S   +    P+ PS   T+ + +P        GTP P
Sbjct: 153 FPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSP 205


>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
            12A isoform a [Homo sapiens]
          Length = 1030

 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 48/135 (35%), Positives = 77/135 (57%), Gaps = 5/135 (3%)

Query: 868  TNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHN 927
            T+L+ P  +R     +V+F+  A+ L A   G+ D V ++++   D +  N +G+T LH 
Sbjct: 22   TDLEPPVVKR--QKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQ 79

Query: 928  AVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISD 987
            A    +  +VKFL++ G N+N  D++GW PLH AASC  + + + L+  GA + A   S+
Sbjct: 80   ACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVN-SE 138

Query: 988  IETAADKCEE--MEE 1000
             +T  D  EE  MEE
Sbjct: 139  GDTPLDIAEEEAMEE 153



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 8/175 (4%)

Query: 836  PVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDA 895
            P+  A S G   +    +   +H  A ++   T L     E     L+   N   + ++A
Sbjct: 109  PLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEA 168

Query: 896  SLEGEFDLVQRIIYEVEDPSKPND-----EGITPLHNAVCAGHHHIVKFLLDFGVNVNAA 950
            + + E  ++ R   +  +    ND      G T LH A   G+  ++K L+  G +VN  
Sbjct: 169  ARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK 228

Query: 951  DSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDI-ETAADKCEEMEEGYIQ 1004
            D DGWTPLH AA       C+ LV++   +    ++ + +TA D  +E   GY++
Sbjct: 229  DYDGWTPLHAAAHWGKEEACRILVDNLCDM--EMVNKVGQTAFDVADEDILGYLE 281


>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit 12A
            isoform a [Homo sapiens]
          Length = 1030

 Score = 77.0 bits (188), Expect = 9e-14
 Identities = 48/135 (35%), Positives = 77/135 (57%), Gaps = 5/135 (3%)

Query: 868  TNLKKPNSERTGHGLRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHN 927
            T+L+ P  +R     +V+F+  A+ L A   G+ D V ++++   D +  N +G+T LH 
Sbjct: 22   TDLEPPVVKR--QKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQ 79

Query: 928  AVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISD 987
            A    +  +VKFL++ G N+N  D++GW PLH AASC  + + + L+  GA + A   S+
Sbjct: 80   ACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVN-SE 138

Query: 988  IETAADKCEE--MEE 1000
             +T  D  EE  MEE
Sbjct: 139  GDTPLDIAEEEAMEE 153



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 46/175 (26%), Positives = 78/175 (44%), Gaps = 8/175 (4%)

Query: 836  PVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDA 895
            P+  A S G   +    +   +H  A ++   T L     E     L+   N   + ++A
Sbjct: 109  PLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEA 168

Query: 896  SLEGEFDLVQRIIYEVEDPSKPND-----EGITPLHNAVCAGHHHIVKFLLDFGVNVNAA 950
            + + E  ++ R   +  +    ND      G T LH A   G+  ++K L+  G +VN  
Sbjct: 169  ARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIK 228

Query: 951  DSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDI-ETAADKCEEMEEGYIQ 1004
            D DGWTPLH AA       C+ LV++   +    ++ + +TA D  +E   GY++
Sbjct: 229  DYDGWTPLHAAAHWGKEEACRILVDNLCDM--EMVNKVGQTAFDVADEDILGYLE 281


>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform b [Homo sapiens]
          Length = 998

 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 42/115 (36%), Positives = 66/115 (57%), Gaps = 1/115 (0%)

Query: 883 RVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLD 942
           RVRF   A+ L A   G+ D V++++    D +  N +G+T LH A    +  +VKFL++
Sbjct: 53  RVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVE 112

Query: 943 FGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEE 997
              NVN  D++GWTPLH AASC  +++ +  +  GA++     S+ E  +D  EE
Sbjct: 113 NRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASV-GIVNSEGEVPSDLAEE 166



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 22/56 (39%), Positives = 29/56 (51%)

Query: 921 GITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVES 976
           G T LH A   G+  +++ L+  G  +N  D DGWTPLH AA       C  L E+
Sbjct: 217 GATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEA 272


>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
           12B isoform a [Homo sapiens]
          Length = 982

 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 42/115 (36%), Positives = 66/115 (57%), Gaps = 1/115 (0%)

Query: 883 RVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLD 942
           RVRF   A+ L A   G+ D V++++    D +  N +G+T LH A    +  +VKFL++
Sbjct: 53  RVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVE 112

Query: 943 FGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTISDIETAADKCEE 997
              NVN  D++GWTPLH AASC  +++ +  +  GA++     S+ E  +D  EE
Sbjct: 113 NRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASV-GIVNSEGEVPSDLAEE 166



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 22/56 (39%), Positives = 29/56 (51%)

Query: 921 GITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVES 976
           G T LH A   G+  +++ L+  G  +N  D DGWTPLH AA       C  L E+
Sbjct: 217 GATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEA 272


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 129/572 (22%), Positives = 193/572 (33%), Gaps = 102/572 (17%)

Query: 351 QVPSAGSFPVLGDPIKPQS----LSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVA 406
           Q P  G  P+ G    PQ+    L +  +A+  ++K A+     ++K +  S  KP    
Sbjct: 250 QPPGTGK-PIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQ 308

Query: 407 GADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYP 466
               K P+ +   ++        P    G T+    + G V PP+   G   PP+     
Sbjct: 309 PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ---- 364

Query: 467 SPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTP--QPGSSQQIQQRISV 524
              PLGP    + +   E    +PS+  P  +     P  G TP  QPG           
Sbjct: 365 ---PLGPAKPPAQQTGSE----KPSSEQPGPKALAQPPGVGKTPAQQPG----------- 406

Query: 525 PPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYL 584
                  PA PP    G  KP     +A +P L       QSP K P    +       +
Sbjct: 407 -------PAKPPTQQVGTPKP-----LAQQPGL-------QSPAKAPGPTKTP------V 441

Query: 585 QQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPS-PLPFLHGSLSTGTPQP---QP 640
           QQ  P K   PA  +   K+     G    PS    P+ P P   G       QP   +P
Sbjct: 442 QQPGPGKI--PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP 499

Query: 641 PSE---STEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRK 697
           PS+   ST+  P+Q GPA P+      + P    P    P    P   +  A        
Sbjct: 500 PSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 559

Query: 698 LANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNT---LAGGMEGTPFYQPSPSQDFMGT 754
              + +PL+  +     + P    + K +    NT   L    E   F   +  Q  + +
Sbjct: 560 QTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCS 619

Query: 755 LADVDNGNTNANGNLEELP--------------------PAQPTAPLPAEPAPSSDANDN 794
           L        N N +L E+                     P+ P   L   P  ++ A   
Sbjct: 620 LC-----GFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSK 674

Query: 795 ELPSPE---PEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAP-------SPG 844
             P P+   P++   P+     A P       +   PT    PS  A+ P        P 
Sbjct: 675 SSPQPQQTSPKKDAAPKQDLSKA-PEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733

Query: 845 EEQVPPAPLPPASHPPATSTNKRTNLKKPNSE 876
             + P  P      P A    K+  + KP ++
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD 765



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 99/461 (21%), Positives = 153/461 (33%), Gaps = 58/461 (12%)

Query: 460 PSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQ 519
           PS+   P+         S  ERR+  ++   + GLP    P   PA   +P     Q++ 
Sbjct: 32  PSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP---PAAAESPSMHRKQELD 88

Query: 520 QRISVPPSPTYPPAGPPAFPAGD---------SKPELPLTVAIRPFLADKGSRPQSPRKG 570
                  S   P  G PA P            S+ +LP        L +  SR     + 
Sbjct: 89  SSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEH 148

Query: 571 PQT--------VNSSSIYSMYLQQATPPK--NYQPAAHSALNKSVKAVYGKPVLPSG--- 617
             +        VN+ S  S  + +  P    +   A+     K  K V  +   P G   
Sbjct: 149 KSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIK 208

Query: 618 ----STSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPT 673
                  P P+P   G       Q   P   + ++PE+     P  G  ++       PT
Sbjct: 209 PPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQ------GPT 262

Query: 674 KLTPIVHSPLRYQSDA------DLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLY 727
           +     H+ L  Q DA        + +R +      P   +  I +P  PG P  Q+  +
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPT-PGKPPAQQPGH 321

Query: 728 QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAP 787
           ++           P     P     GT+              + L PA+P A       P
Sbjct: 322 EKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP 381

Query: 788 SSDANDNELPSPEPEELICP----QTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSP 843
           SS+        P P+ L  P    +T  Q   PA+     V T     Q P   + A +P
Sbjct: 382 SSE-------QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434

Query: 844 GEEQVP-----PAPLPPASHPPATSTNKRTNLKKPNSERTG 879
           G  + P     P  +P     P  ++ ++T   KP S+  G
Sbjct: 435 GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 475



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 149/723 (20%), Positives = 246/723 (34%), Gaps = 126/723 (17%)

Query: 243 EDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQ--QKELLNKRN 300
           E+ K   + GF S    L+  ++V  K    +L   ++ +QE+ +K Q+  QKE      
Sbjct: 146 EEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEG 205

Query: 301 MEVAMMDKRISELRERLYGKKIQLNRVNGTS---SPQSPLSTSGRVAAVGPYIQVPSA-- 355
           +    + ++  +   +  G      + +GT    S Q P     +    G  IQ P+   
Sbjct: 206 IIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTP 265

Query: 356 ----GSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWK 411
                  P+  D  +PQ+             S    + P ++Q +     P Q  G +  
Sbjct: 266 QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGK-PPAQQPGHEKS 324

Query: 412 DPSVEGSVKQGTVSSQPV---------PFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSY 462
            P       Q +  ++P+         P    G T+ P   +G   PP    G + P S 
Sbjct: 325 QPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSE 384

Query: 463 GTYPSPT--PLGPGSTSSLER------RKEGSLPRPSAGLPSRQRPTLLPATGSTPQ--- 511
              P     P G G T + +        ++   P+P A  P  Q P   P    TP    
Sbjct: 385 QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 444

Query: 512 -----------PGSSQQIQQRISVPPS---------PTYP-PAGPPAFPAGDSKPELPLT 550
                      PG +   Q   + PPS         P  P PA PP    G +KP     
Sbjct: 445 GPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP 504

Query: 551 VAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYG 610
            + +P     G    SP++   T   S         A  P   +P+A  +     +   G
Sbjct: 505 GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 564

Query: 611 KPVLPSGSTSPSPLPFLHGSLSTGTP----------QPQPPSESTEKEPE---------- 650
           KP+ P   +  +  P   G   T  P           P+  + +T  E +          
Sbjct: 565 KPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN 624

Query: 651 ----------------QDGPAAPADGSTVESLPRP---LSPTKLTPIV--HSPLRYQSDA 689
                           Q   A   D + V S P+P    +P   T  V   SP   Q+  
Sbjct: 625 PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSP 684

Query: 690 DLEAL-RRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPS-P 747
             +A  ++ L+ AP P K    + +P   G P+ +       ++L+   +  P  +PS P
Sbjct: 685 KKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLS---KPAPPKEPSVP 741

Query: 748 SQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPE-PEELIC 806
           S+     +AD                  +P  P   +P     ++ +    P+ P   + 
Sbjct: 742 SEQDKAPVAD-----------------DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 807 PQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPA---SHPPATS 863
            Q   +T  P + +     +   ++  P P  E  SP + +  P P   +   SHP  +S
Sbjct: 785 SQAEEKTTPPLKTD-----SAKPSQSFP-PTGEKVSPFDSKAIPRPASDSKIISHPGPSS 838

Query: 864 TNK 866
            +K
Sbjct: 839 ESK 841



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 92/392 (23%), Positives = 129/392 (32%), Gaps = 91/392 (23%)

Query: 489 RPSAGLPSRQRPTLLPAT-GSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPEL 547
           +P   +P +Q P   P     TP+  SSQQ ++  S PP    P  GP   P  D   +L
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHA-KL 272

Query: 548 PLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKA 607
           PL            SRPQ+  K    V   S+                            
Sbjct: 273 PLQ--------RDASRPQT--KQADIVRGESV---------------------------- 294

Query: 608 VYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLP 667
              KP LPS S  P   P         TP  +PP++    E  Q GPA P    +  + P
Sbjct: 295 ---KPSLPSPSKPPIQQP---------TPG-KPPAQQPGHEKSQPGPAKPPAQPSGLTKP 341

Query: 668 RPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLY 727
               P  + P V  P   +  A      + L  A  P ++  S        GP   K L 
Sbjct: 342 LAQQPGTVKPPVQPPGTTKPPA------QPLGPAKPPAQQTGSEKPSSEQPGP---KALA 392

Query: 728 QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAP 787
           Q       G+  TP  QP P                 A    +++   +P A  P   +P
Sbjct: 393 Q-----PPGVGKTPAQQPGP-----------------AKPPTQQVGTPKPLAQQPGLQSP 430

Query: 788 SSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQ 847
           +      + P  +P     P    Q A P + +           Q+P P    P    +Q
Sbjct: 431 AKAPGPTKTPVQQPGPGKIPA---QQAGPGKTSAQQTGPTKPPSQLPGPAKPPP----QQ 483

Query: 848 VPPAPLPPASHPPATSTNKRTNLKKPNSERTG 879
             PA  PP     A   +++    KP  ++ G
Sbjct: 484 PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPG 515



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 89/416 (21%), Positives = 146/416 (35%), Gaps = 60/416 (14%)

Query: 466  PSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPA-TGSTPQPGSSQQIQQRISV 524
            P P    P   ++  ++     P P    P  ++PTL  + +    QP  +  + +    
Sbjct: 677  PQPQQTSPKKDAA-PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSK--PA 733

Query: 525  PPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYL 584
            PP     P+     P  D KP+ P  V     L    S    P      + SS + S   
Sbjct: 734  PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKP-----DIPSSKVQSQAE 788

Query: 585  QQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSES 644
            ++ TPP              +K    KP      T     PF   ++      P+P S+S
Sbjct: 789  EKTTPP--------------LKTDSAKPSQSFPPTGEKVSPFDSKAI------PRPASDS 828

Query: 645  TEKEPEQDGPAAPADGST-VESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPR 703
              K     GP++ + G   V+ + +   P K      + +  + DA            PR
Sbjct: 829  --KIISHPGPSSESKGQKQVDPVQKKEEPKK----AQTKMSPKPDAKPMPKGSPTPPGPR 882

Query: 704  PLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQD-----FMGTLADV 758
            P   ++  T  + P  P  Q    +RF+   G +   P  QP+  Q+       G  A +
Sbjct: 883  PTAGQTVPTPQQSPK-PQEQS---RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASI 938

Query: 759  DNGNTNANGNLEELPPAQPTAP-LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPA 817
             +  +N      +  P   + P  P + AP+        PS  P     P++T Q A PA
Sbjct: 939  FSQASNLISTAGQPGPHSQSGPGAPMKQAPA--------PSQPPTSQGPPKSTGQ-APPA 989

Query: 818  EDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKP 873
                    ++P  ++  +P AE   P  EQ P          P    + ++   +P
Sbjct: 990  P-----AKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEP 1040



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 95/457 (20%), Positives = 155/457 (33%), Gaps = 83/457 (18%)

Query: 396  SSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVG 455
            S SS +P Q +    KD + +  + +     +P P               K PP    + 
Sbjct: 673  SKSSPQPQQTSPK--KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLS 730

Query: 456  KQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSS 515
            K  PP   + PS     P +    ++ K+  + +P+  L S    T  P     P     
Sbjct: 731  KPAPPKEPSVPSEQDKAPVAD---DKPKQPKMVKPTTDLVSSSSATTKP---DIPSSKVQ 784

Query: 516  QQIQQRISVP-------PSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPR 568
             Q +++ + P       PS ++PP G    P  DSK  +P   +    ++  G  P S  
Sbjct: 785  SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF-DSKA-IPRPASDSKIISHPG--PSSES 840

Query: 569  KGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLH 628
            KG + V+        +Q+   PK  Q        K       KP+     T P P P   
Sbjct: 841  KGQKQVDP-------VQKKEEPKKAQ-------TKMSPKPDAKPMPKGSPTPPGPRPTAG 886

Query: 629  GSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSD 688
             ++ T    P+P  +S                              L  I  +P + Q  
Sbjct: 887  QTVPTPQQSPKPQEQSRR------------------------FSLNLGSITDAP-KSQPT 921

Query: 689  ADLEALRRKLANAPRPL-KKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQ-PS 746
               E +  KL      +  + S++    G  GP+ Q               G P  Q P+
Sbjct: 922  TPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQ------------SGPGAPMKQAPA 969

Query: 747  PSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELIC 806
            PSQ           G   + G   + PPA P   +P +    + A +   P  E    + 
Sbjct: 970  PSQ------PPTSQGPPKSTG---QAPPA-PAKSIPVKKETKAPAAEKLEPKAEQAPTVK 1019

Query: 807  PQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSP 843
               T +   P +D+ +  A  P    +P+ + ++P P
Sbjct: 1020 RTETEKKPPPIKDSKSLTAE-PQKAVLPTKLEKSPKP 1055



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 56/231 (24%), Positives = 81/231 (35%), Gaps = 43/231 (18%)

Query: 495  PSRQRPTLLPATGSTP---QPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV 551
            P+ Q P+  P+  S P   +P          + PP P  PP  PP  P     P LP   
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPT 2431

Query: 552  AIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVY-- 609
            + +P +  K                       L  A+P     P   +       AV   
Sbjct: 2432 SPKPTILPKKK---------------------LTVASPVTTATPLFDAVTTLETTAVLRS 2470

Query: 610  -GKPVLPSGSTSPSPLPFLHGSLSTG---TPQPQPPSESTEKEPEQDGPAAPADGSTVES 665
             G PV    +T+P P+P    S+ +G   T +P+P      K P    P  P   +T + 
Sbjct: 2471 NGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEP-----SKPPIAPKPVIPQLPTTTQK 2525

Query: 666  LPRPL--SPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEP 714
             P  +   PT L+      L   + AD      KL +   PL   S+ + P
Sbjct: 2526 -PTDIHPKPTGLSLTSSMTLNLVTSADY-----KLPSPTSPLSPHSNKSSP 2570



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 34/133 (25%), Positives = 66/133 (49%), Gaps = 18/133 (13%)

Query: 137  RQQQQIENQQQMLVA---KEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKI 193
            +QQQQ++ ++++L     K+QR     + ER++ Q   E EK+   K        KL+++
Sbjct: 3209 KQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQK--------KLEEL 3260

Query: 194  RAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQL-EDLKKGKLNG 252
            ++M+  + + +        E +    M QE   + Q  + ++ QL QQL + L++ K+  
Sbjct: 3261 QSMKQHLLFQQ------EEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKIRQ 3314

Query: 253  FQSYNGKLTGPAA 265
               YN   +G A+
Sbjct: 3315 IYQYNYDPSGTAS 3327



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 35/156 (22%), Positives = 51/156 (32%), Gaps = 17/156 (10%)

Query: 773  PPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQ 832
            PP  P  P P  P P      +  P+  P++ +   +   TA P  D    + T      
Sbjct: 2411 PPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRS 2470

Query: 833  IPSPVAEAPSPGEEQVPPAP-----------LPPASHPPATSTNKRTNLKKPNSERTGHG 881
               PV    +     VPP P            P  S PP         L     + T   
Sbjct: 2471 NGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTD-- 2528

Query: 882  LRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKP 917
              +   P  L L +S+    +LV    Y++  P+ P
Sbjct: 2529 --IHPKPTGLSLTSSM--TLNLVTSADYKLPSPTSP 2560



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 28/104 (26%), Positives = 34/104 (32%), Gaps = 3/104 (2%)

Query: 773  PPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEP---AEDNNNNVATVPT 829
            PP  P  P P  P P         P   P+  I P+     A P   A    + V T+ T
Sbjct: 2405 PPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLET 2464

Query: 830  TEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKP 873
            T  + S             PP P  P+S P       R    KP
Sbjct: 2465 TAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKP 2508



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 56/226 (24%), Positives = 81/226 (35%), Gaps = 31/226 (13%)

Query: 417  GSVKQGTVSSQPVPF---SALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGP 473
            GS    ++ ++P PF   S+L  + +P       PPP P      PP     P P P  P
Sbjct: 2379 GSPSVSSLPAKPRPFFRSSSLDISAQP-----PPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433

Query: 474  GSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPA 533
              T   +++   + P  +A  P     T L  T      G       RI     P  PP 
Sbjct: 2434 KPTILPKKKLTVASPVTTA-TPLFDAVTTLETTAVLRSNGLP---VTRICTTAPPPVPPK 2489

Query: 534  GPPAFPAG-----DSKPELPLTVAIRPFLADKGSRPQSPRK-GPQTVNSSSIYSMYLQQA 587
             P + P+G       +P  P  +A +P +    +  Q P    P+    S   SM L   
Sbjct: 2490 -PSSIPSGLVFTHRPEPSKP-PIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLV 2547

Query: 588  TPPKNYQPAAHSAL-----------NKSVKAVYGKPVLPSGSTSPS 622
            T      P+  S L           +KS+   Y    LPS   +P+
Sbjct: 2548 TSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPT 2593



 Score = 30.4 bits (67), Expect = 9.5
 Identities = 20/74 (27%), Positives = 28/74 (37%), Gaps = 6/74 (8%)

Query: 794  NELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPL 853
            ++LPS  P     P      A+P     ++   +      P P    P P     PP PL
Sbjct: 2374 SQLPSGSPSVSSLP------AKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPL 2427

Query: 854  PPASHPPATSTNKR 867
            PP + P  T   K+
Sbjct: 2428 PPPTSPKPTILPKK 2441


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 72.0 bits (175), Expect = 3e-12
 Identities = 129/572 (22%), Positives = 193/572 (33%), Gaps = 102/572 (17%)

Query: 351 QVPSAGSFPVLGDPIKPQS----LSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVA 406
           Q P  G  P+ G    PQ+    L +  +A+  ++K A+     ++K +  S  KP    
Sbjct: 250 QPPGTGK-PIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQ 308

Query: 407 GADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYP 466
               K P+ +   ++        P    G T+    + G V PP+   G   PP+     
Sbjct: 309 PTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQ---- 364

Query: 467 SPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTP--QPGSSQQIQQRISV 524
              PLGP    + +   E    +PS+  P  +     P  G TP  QPG           
Sbjct: 365 ---PLGPAKPPAQQTGSE----KPSSEQPGPKALAQPPGVGKTPAQQPG----------- 406

Query: 525 PPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYL 584
                  PA PP    G  KP     +A +P L       QSP K P    +       +
Sbjct: 407 -------PAKPPTQQVGTPKP-----LAQQPGL-------QSPAKAPGPTKTP------V 441

Query: 585 QQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPS-PLPFLHGSLSTGTPQP---QP 640
           QQ  P K   PA  +   K+     G    PS    P+ P P   G       QP   +P
Sbjct: 442 QQPGPGKI--PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP 499

Query: 641 PSE---STEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRK 697
           PS+   ST+  P+Q GPA P+      + P    P    P    P   +  A        
Sbjct: 500 PSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVS 559

Query: 698 LANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNT---LAGGMEGTPFYQPSPSQDFMGT 754
              + +PL+  +     + P    + K +    NT   L    E   F   +  Q  + +
Sbjct: 560 QTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCS 619

Query: 755 LADVDNGNTNANGNLEELP--------------------PAQPTAPLPAEPAPSSDANDN 794
           L        N N +L E+                     P+ P   L   P  ++ A   
Sbjct: 620 LC-----GFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSK 674

Query: 795 ELPSPE---PEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAP-------SPG 844
             P P+   P++   P+     A P       +   PT    PS  A+ P        P 
Sbjct: 675 SSPQPQQTSPKKDAAPKQDLSKA-PEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733

Query: 845 EEQVPPAPLPPASHPPATSTNKRTNLKKPNSE 876
             + P  P      P A    K+  + KP ++
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTD 765



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 99/461 (21%), Positives = 153/461 (33%), Gaps = 58/461 (12%)

Query: 460 PSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQ 519
           PS+   P+         S  ERR+  ++   + GLP    P   PA   +P     Q++ 
Sbjct: 32  PSHTAIPAGMEADLSQLSEEERRQIAAVMSRAQGLPKGSVP---PAAAESPSMHRKQELD 88

Query: 520 QRISVPPSPTYPPAGPPAFPAGD---------SKPELPLTVAIRPFLADKGSRPQSPRKG 570
                  S   P  G PA P            S+ +LP        L +  SR     + 
Sbjct: 89  SSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEH 148

Query: 571 PQT--------VNSSSIYSMYLQQATPPK--NYQPAAHSALNKSVKAVYGKPVLPSG--- 617
             +        VN+ S  S  + +  P    +   A+     K  K V  +   P G   
Sbjct: 149 KSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEGIIK 208

Query: 618 ----STSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPT 673
                  P P+P   G       Q   P   + ++PE+     P  G  ++       PT
Sbjct: 209 PPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQ------GPT 262

Query: 674 KLTPIVHSPLRYQSDA------DLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLY 727
           +     H+ L  Q DA        + +R +      P   +  I +P  PG P  Q+  +
Sbjct: 263 QTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPT-PGKPPAQQPGH 321

Query: 728 QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAP 787
           ++           P     P     GT+              + L PA+P A       P
Sbjct: 322 EKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKP 381

Query: 788 SSDANDNELPSPEPEELICP----QTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSP 843
           SS+        P P+ L  P    +T  Q   PA+     V T     Q P   + A +P
Sbjct: 382 SSE-------QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434

Query: 844 GEEQVP-----PAPLPPASHPPATSTNKRTNLKKPNSERTG 879
           G  + P     P  +P     P  ++ ++T   KP S+  G
Sbjct: 435 GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPG 475



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 149/723 (20%), Positives = 246/723 (34%), Gaps = 126/723 (17%)

Query: 243 EDLKKGKLNGFQSYNGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQ--QKELLNKRN 300
           E+ K   + GF S    L+  ++V  K    +L   ++ +QE+ +K Q+  QKE      
Sbjct: 146 EEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEETTKKQKVVQKEQGKPEG 205

Query: 301 MEVAMMDKRISELRERLYGKKIQLNRVNGTS---SPQSPLSTSGRVAAVGPYIQVPSA-- 355
           +    + ++  +   +  G      + +GT    S Q P     +    G  IQ P+   
Sbjct: 206 IIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTP 265

Query: 356 ----GSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWK 411
                  P+  D  +PQ+             S    + P ++Q +     P Q  G +  
Sbjct: 266 QTDHAKLPLQRDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTPGK-PPAQQPGHEKS 324

Query: 412 DPSVEGSVKQGTVSSQPV---------PFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSY 462
            P       Q +  ++P+         P    G T+ P   +G   PP    G + P S 
Sbjct: 325 QPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSE 384

Query: 463 GTYPSPT--PLGPGSTSSLER------RKEGSLPRPSAGLPSRQRPTLLPATGSTPQ--- 511
              P     P G G T + +        ++   P+P A  P  Q P   P    TP    
Sbjct: 385 QPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAPGPTKTPVQQP 444

Query: 512 -----------PGSSQQIQQRISVPPS---------PTYP-PAGPPAFPAGDSKPELPLT 550
                      PG +   Q   + PPS         P  P PA PP    G +KP     
Sbjct: 445 GPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQP 504

Query: 551 VAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYG 610
            + +P     G    SP++   T   S         A  P   +P+A  +     +   G
Sbjct: 505 GSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 564

Query: 611 KPVLPSGSTSPSPLPFLHGSLSTGTP----------QPQPPSESTEKEPE---------- 650
           KP+ P   +  +  P   G   T  P           P+  + +T  E +          
Sbjct: 565 KPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHVPEKANFNTCTECQTTVCSLCGFN 624

Query: 651 ----------------QDGPAAPADGSTVESLPRP---LSPTKLTPIV--HSPLRYQSDA 689
                           Q   A   D + V S P+P    +P   T  V   SP   Q+  
Sbjct: 625 PNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKLKTAPVTTTSAVSKSSPQPQQTSP 684

Query: 690 DLEAL-RRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPS-P 747
             +A  ++ L+ AP P K    + +P   G P+ +       ++L+   +  P  +PS P
Sbjct: 685 KKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLS---KPAPPKEPSVP 741

Query: 748 SQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPE-PEELIC 806
           S+     +AD                  +P  P   +P     ++ +    P+ P   + 
Sbjct: 742 SEQDKAPVAD-----------------DKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQ 784

Query: 807 PQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPA---SHPPATS 863
            Q   +T  P + +     +   ++  P P  E  SP + +  P P   +   SHP  +S
Sbjct: 785 SQAEEKTTPPLKTD-----SAKPSQSFP-PTGEKVSPFDSKAIPRPASDSKIISHPGPSS 838

Query: 864 TNK 866
            +K
Sbjct: 839 ESK 841



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 92/392 (23%), Positives = 129/392 (32%), Gaps = 91/392 (23%)

Query: 489 RPSAGLPSRQRPTLLPAT-GSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPEL 547
           +P   +P +Q P   P     TP+  SSQQ ++  S PP    P  GP   P  D   +L
Sbjct: 214 QPPKPIPKQQGPGRDPLQQDGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHA-KL 272

Query: 548 PLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKA 607
           PL            SRPQ+  K    V   S+                            
Sbjct: 273 PLQ--------RDASRPQT--KQADIVRGESV---------------------------- 294

Query: 608 VYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLP 667
              KP LPS S  P   P         TP  +PP++    E  Q GPA P    +  + P
Sbjct: 295 ---KPSLPSPSKPPIQQP---------TPG-KPPAQQPGHEKSQPGPAKPPAQPSGLTKP 341

Query: 668 RPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLY 727
               P  + P V  P   +  A      + L  A  P ++  S        GP   K L 
Sbjct: 342 LAQQPGTVKPPVQPPGTTKPPA------QPLGPAKPPAQQTGSEKPSSEQPGP---KALA 392

Query: 728 QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAP 787
           Q       G+  TP  QP P                 A    +++   +P A  P   +P
Sbjct: 393 Q-----PPGVGKTPAQQPGP-----------------AKPPTQQVGTPKPLAQQPGLQSP 430

Query: 788 SSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQ 847
           +      + P  +P     P    Q A P + +           Q+P P    P    +Q
Sbjct: 431 AKAPGPTKTPVQQPGPGKIPA---QQAGPGKTSAQQTGPTKPPSQLPGPAKPPP----QQ 483

Query: 848 VPPAPLPPASHPPATSTNKRTNLKKPNSERTG 879
             PA  PP     A   +++    KP  ++ G
Sbjct: 484 PGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPG 515



 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 89/416 (21%), Positives = 146/416 (35%), Gaps = 60/416 (14%)

Query: 466  PSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPA-TGSTPQPGSSQQIQQRISV 524
            P P    P   ++  ++     P P    P  ++PTL  + +    QP  +  + +    
Sbjct: 677  PQPQQTSPKKDAA-PKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSK--PA 733

Query: 525  PPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYL 584
            PP     P+     P  D KP+ P  V     L    S    P      + SS + S   
Sbjct: 734  PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKP-----DIPSSKVQSQAE 788

Query: 585  QQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSES 644
            ++ TPP              +K    KP      T     PF   ++      P+P S+S
Sbjct: 789  EKTTPP--------------LKTDSAKPSQSFPPTGEKVSPFDSKAI------PRPASDS 828

Query: 645  TEKEPEQDGPAAPADGST-VESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPR 703
              K     GP++ + G   V+ + +   P K      + +  + DA            PR
Sbjct: 829  --KIISHPGPSSESKGQKQVDPVQKKEEPKK----AQTKMSPKPDAKPMPKGSPTPPGPR 882

Query: 704  PLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQD-----FMGTLADV 758
            P   ++  T  + P  P  Q    +RF+   G +   P  QP+  Q+       G  A +
Sbjct: 883  PTAGQTVPTPQQSPK-PQEQS---RRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASI 938

Query: 759  DNGNTNANGNLEELPPAQPTAP-LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPA 817
             +  +N      +  P   + P  P + AP+        PS  P     P++T Q A PA
Sbjct: 939  FSQASNLISTAGQPGPHSQSGPGAPMKQAPA--------PSQPPTSQGPPKSTGQ-APPA 989

Query: 818  EDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKP 873
                    ++P  ++  +P AE   P  EQ P          P    + ++   +P
Sbjct: 990  P-----AKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTAEP 1040



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 95/457 (20%), Positives = 155/457 (33%), Gaps = 83/457 (18%)

Query: 396  SSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVG 455
            S SS +P Q +    KD + +  + +     +P P               K PP    + 
Sbjct: 673  SKSSPQPQQTSPK--KDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLS 730

Query: 456  KQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSS 515
            K  PP   + PS     P +    ++ K+  + +P+  L S    T  P     P     
Sbjct: 731  KPAPPKEPSVPSEQDKAPVAD---DKPKQPKMVKPTTDLVSSSSATTKP---DIPSSKVQ 784

Query: 516  QQIQQRISVP-------PSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPR 568
             Q +++ + P       PS ++PP G    P  DSK  +P   +    ++  G  P S  
Sbjct: 785  SQAEEKTTPPLKTDSAKPSQSFPPTGEKVSPF-DSKA-IPRPASDSKIISHPG--PSSES 840

Query: 569  KGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLH 628
            KG + V+        +Q+   PK  Q        K       KP+     T P P P   
Sbjct: 841  KGQKQVDP-------VQKKEEPKKAQ-------TKMSPKPDAKPMPKGSPTPPGPRPTAG 886

Query: 629  GSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSD 688
             ++ T    P+P  +S                              L  I  +P + Q  
Sbjct: 887  QTVPTPQQSPKPQEQSRR------------------------FSLNLGSITDAP-KSQPT 921

Query: 689  ADLEALRRKLANAPRPL-KKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQ-PS 746
               E +  KL      +  + S++    G  GP+ Q               G P  Q P+
Sbjct: 922  TPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQ------------SGPGAPMKQAPA 969

Query: 747  PSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELIC 806
            PSQ           G   + G   + PPA P   +P +    + A +   P  E    + 
Sbjct: 970  PSQ------PPTSQGPPKSTG---QAPPA-PAKSIPVKKETKAPAAEKLEPKAEQAPTVK 1019

Query: 807  PQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSP 843
               T +   P +D+ +  A  P    +P+ + ++P P
Sbjct: 1020 RTETEKKPPPIKDSKSLTAE-PQKAVLPTKLEKSPKP 1055



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 56/231 (24%), Positives = 81/231 (35%), Gaps = 43/231 (18%)

Query: 495  PSRQRPTLLPATGSTP---QPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV 551
            P+ Q P+  P+  S P   +P          + PP P  PP  PP  P     P LP   
Sbjct: 2372 PASQLPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPT 2431

Query: 552  AIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVY-- 609
            + +P +  K                       L  A+P     P   +       AV   
Sbjct: 2432 SPKPTILPKKK---------------------LTVASPVTTATPLFDAVTTLETTAVLRS 2470

Query: 610  -GKPVLPSGSTSPSPLPFLHGSLSTG---TPQPQPPSESTEKEPEQDGPAAPADGSTVES 665
             G PV    +T+P P+P    S+ +G   T +P+P      K P    P  P   +T + 
Sbjct: 2471 NGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEP-----SKPPIAPKPVIPQLPTTTQK 2525

Query: 666  LPRPL--SPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEP 714
             P  +   PT L+      L   + AD      KL +   PL   S+ + P
Sbjct: 2526 -PTDIHPKPTGLSLTSSMTLNLVTSADY-----KLPSPTSPLSPHSNKSSP 2570



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 34/133 (25%), Positives = 66/133 (49%), Gaps = 18/133 (13%)

Query: 137  RQQQQIENQQQMLVA---KEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKI 193
            +QQQQ++ ++++L     K+QR     + ER++ Q   E EK+   K        KL+++
Sbjct: 3209 KQQQQLDLERELLELEKIKQQRFAEELEWERQEIQRFREQEKIMVQK--------KLEEL 3260

Query: 194  RAMRGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQL-EDLKKGKLNG 252
            ++M+  + + +        E +    M QE   + Q  + ++ QL QQL + L++ K+  
Sbjct: 3261 QSMKQHLLFQQ------EEERQAQFMMRQETLAQQQLQLEQIQQLQQQLHQQLEEQKIRQ 3314

Query: 253  FQSYNGKLTGPAA 265
               YN   +G A+
Sbjct: 3315 IYQYNYDPSGTAS 3327



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 35/156 (22%), Positives = 51/156 (32%), Gaps = 17/156 (10%)

Query: 773  PPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQ 832
            PP  P  P P  P P      +  P+  P++ +   +   TA P  D    + T      
Sbjct: 2411 PPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTAVLRS 2470

Query: 833  IPSPVAEAPSPGEEQVPPAP-----------LPPASHPPATSTNKRTNLKKPNSERTGHG 881
               PV    +     VPP P            P  S PP         L     + T   
Sbjct: 2471 NGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIPQLPTTTQKPTD-- 2528

Query: 882  LRVRFNPLALLLDASLEGEFDLVQRIIYEVEDPSKP 917
              +   P  L L +S+    +LV    Y++  P+ P
Sbjct: 2529 --IHPKPTGLSLTSSM--TLNLVTSADYKLPSPTSP 2560



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 28/104 (26%), Positives = 34/104 (32%), Gaps = 3/104 (2%)

Query: 773  PPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEP---AEDNNNNVATVPT 829
            PP  P  P P  P P         P   P+  I P+     A P   A    + V T+ T
Sbjct: 2405 PPPPPPPPPPPPPPPPPPPPPPLPPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLET 2464

Query: 830  TEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKP 873
            T  + S             PP P  P+S P       R    KP
Sbjct: 2465 TAVLRSNGLPVTRICTTAPPPVPPKPSSIPSGLVFTHRPEPSKP 2508



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 56/226 (24%), Positives = 81/226 (35%), Gaps = 31/226 (13%)

Query: 417  GSVKQGTVSSQPVPF---SALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPLGP 473
            GS    ++ ++P PF   S+L  + +P       PPP P      PP     P P P  P
Sbjct: 2379 GSPSVSSLPAKPRPFFRSSSLDISAQP-----PPPPPPPPPPPPPPPPPPPPPLPPPTSP 2433

Query: 474  GSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPA 533
              T   +++   + P  +A  P     T L  T      G       RI     P  PP 
Sbjct: 2434 KPTILPKKKLTVASPVTTA-TPLFDAVTTLETTAVLRSNGLP---VTRICTTAPPPVPPK 2489

Query: 534  GPPAFPAG-----DSKPELPLTVAIRPFLADKGSRPQSPRK-GPQTVNSSSIYSMYLQQA 587
             P + P+G       +P  P  +A +P +    +  Q P    P+    S   SM L   
Sbjct: 2490 -PSSIPSGLVFTHRPEPSKP-PIAPKPVIPQLPTTTQKPTDIHPKPTGLSLTSSMTLNLV 2547

Query: 588  TPPKNYQPAAHSAL-----------NKSVKAVYGKPVLPSGSTSPS 622
            T      P+  S L           +KS+   Y    LPS   +P+
Sbjct: 2548 TSADYKLPSPTSPLSPHSNKSSPRFSKSLTETYVVITLPSEPGTPT 2593



 Score = 30.4 bits (67), Expect = 9.5
 Identities = 20/74 (27%), Positives = 28/74 (37%), Gaps = 6/74 (8%)

Query: 794  NELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPL 853
            ++LPS  P     P      A+P     ++   +      P P    P P     PP PL
Sbjct: 2374 SQLPSGSPSVSSLP------AKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPL 2427

Query: 854  PPASHPPATSTNKR 867
            PP + P  T   K+
Sbjct: 2428 PPPTSPKPTILPKK 2441


>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
          Length = 300

 Score = 70.9 bits (172), Expect = 6e-12
 Identities = 42/120 (35%), Positives = 64/120 (53%), Gaps = 3/120 (2%)

Query: 889  LALLLDASLEGEFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVN 948
            L  L D++   + + VQ+++ +  DP   +D+G T LH A C G+  IV+ LLD G + N
Sbjct: 111  LKRLRDSANANDVETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPN 170

Query: 949  AADSDGWTPLHCAASCNSVHLCKQLVESGAAIFA---STISDIETAADKCEEMEEGYIQC 1005
              D  G TPLH AA  N V +   L+  GA + A   +  + +  A  K   ++EG+ QC
Sbjct: 171  QRDGLGNTPLHLAACTNHVPVITTLLRGGARVDALDRAGRTPLHLAKSKLNILQEGHAQC 230


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 112/462 (24%), Positives = 169/462 (36%), Gaps = 62/462 (13%)

Query: 435 GPTEKPGIEIGKVPP---PIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPS 491
           G  ++P    G+  P    I   G+  P +  T  + +       S+ + ++E S P  S
Sbjct: 33  GRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKS 92

Query: 492 AGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV 551
                RQR  +   T    +  S +   Q IS P SP+          + DS+  +    
Sbjct: 93  N---KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEG-----ESSDSR-SVNDEG 143

Query: 552 AIRPFLADKGSRPQSPR-KGPQTVNSSSIYSMYLQ--QATPPKNYQPAAHSALNKSVKAV 608
           +  P   D+ +R  SP    PQ   S S  S   Q  QA PP    P   +    S  A 
Sbjct: 144 SSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSS--AP 201

Query: 609 YGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPR 668
            G P LP+    P P P    S +   PQ  P +     +P+   P AP   + ++  P 
Sbjct: 202 PGTPQLPT----PGPTP----SATAVPPQGSPTASQAPNQPQ--APTAPVPHTHIQQAPA 251

Query: 669 PLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQK---L 725
            L P +  P  H P        L+ L         P   +  +   +GP GP+  +   L
Sbjct: 252 -LHPQR-PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPL-HGQGPPGPHSLQAGPL 308

Query: 726 LY-----QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNL----EELPPAQ 776
           L      Q F       +G      SP+  +  T   +    +          + LPPA 
Sbjct: 309 LQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAP 368

Query: 777 ---------PTAPLPAEPAPSSDANDNELPSPEPEEL---------ICPQTTHQTAEPAE 818
                    PT P+P  PAP +  +   L  P P  +         + P ++  T  P  
Sbjct: 369 LAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 428

Query: 819 DNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPP 860
            +   +  +P ++ +PS  A+ P  G  Q    P PPASHPP
Sbjct: 429 AHPPPLQLMPQSQPLPSSPAQPP--GLTQSQNLPPPPASHPP 468



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 110/448 (24%), Positives = 146/448 (32%), Gaps = 55/448 (12%)

Query: 390 PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
           P+ + N S S    Q      + P+++         S   P +   PT  P      VPP
Sbjct: 162 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 221

Query: 450 PIPGVGKQLP--PSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATG 507
                  Q P  P   T P P      + +   +R     P P    PS   P L P TG
Sbjct: 222 QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH---PS-PHPPLQPLTG 277

Query: 508 STPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSP 567
           S  QP +    Q     PP     P GP +  AG             P L   G  PQ  
Sbjct: 278 SAGQPSAPSHAQ-----PPLHGQGPPGPHSLQAG-------------PLLQHPGP-PQPF 318

Query: 568 RKGPQTVNSSSIYSMYLQQATPPKNYQ-PAAHSALNKSVKAVYGKPVLPSGSTSPSPLPF 626
              PQ     +        A P  + Q PA+ SAL +S +    +P+       P+PL  
Sbjct: 319 GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSAL-QSQQPPREQPL------PPAPLAM 371

Query: 627 LHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRP--LSPTKLTPIVHSPLR 684
            H      TP PQ P+    K P     + P+  S   +LP P  L P       H P  
Sbjct: 372 PHIKPPPTTPIPQLPAPQAHKHPPH--LSGPSPFSMNANLPPPPALKPLSSLSTHHPPSA 429

Query: 685 YQSDADLEALRRKLANAPRP---LKKRSSITEPEGPGGPN------IQKLLYQRFNTLAG 735
           +     L    + L ++P     L +  ++  P     P        Q    Q      G
Sbjct: 430 HPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGG 489

Query: 736 GMEGTPFYQPSPSQDFMGTLADVD--------NGNTNANGNLEELPPAQ-PTAPLPAEPA 786
               TP   PS S    G              +G + A G+   LP  Q     L     
Sbjct: 490 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 549

Query: 787 PSSDANDNELPSPEPEELICPQTTHQTA 814
           P S       PSPEP  +  P    Q+A
Sbjct: 550 PESPPPPPRSPSPEPTVVDTPSHASQSA 577



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 62/230 (26%), Positives = 81/230 (35%), Gaps = 44/230 (19%)

Query: 331 SSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWP 390
           S  Q+PL TS   A     +Q+P++ S      P + Q L  A  A             P
Sbjct: 325 SQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAM------------P 372

Query: 391 TLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVP-----FSALGPTEKPGIEIG 445
            +K   ++ +  +    A    P + G       ++ P P      S+L     P     
Sbjct: 373 HIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAH-- 430

Query: 446 KVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPA 505
             PPP+     QL P     PS     PG T S       +LP P A  P    PT L  
Sbjct: 431 --PPPL-----QLMPQSQPLPSSPAQPPGLTQSQ------NLPPPPASHP----PTGLHQ 473

Query: 506 TGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRP 555
               PQP       Q   VP  P  PP  PP  P+  + P  P T A  P
Sbjct: 474 VA--PQP----PFAQHPFVPGGP--PPITPPTCPSTSTPPAGPGTSAQPP 515


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 112/462 (24%), Positives = 169/462 (36%), Gaps = 62/462 (13%)

Query: 435  GPTEKPGIEIGKVPP---PIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPS 491
            G  ++P    G+  P    I   G+  P +  T  + +       S+ + ++E S P  S
Sbjct: 587  GRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKS 646

Query: 492  AGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV 551
                 RQR  +   T    +  S +   Q IS P SP+          + DS+  +    
Sbjct: 647  N---KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEG-----ESSDSR-SVNDEG 697

Query: 552  AIRPFLADKGSRPQSPR-KGPQTVNSSSIYSMYLQ--QATPPKNYQPAAHSALNKSVKAV 608
            +  P   D+ +R  SP    PQ   S S  S   Q  QA PP    P   +    S  A 
Sbjct: 698  SSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSS--AP 755

Query: 609  YGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPR 668
             G P LP+    P P P    S +   PQ  P +     +P+   P AP   + ++  P 
Sbjct: 756  PGTPQLPT----PGPTP----SATAVPPQGSPTASQAPNQPQ--APTAPVPHTHIQQAPA 805

Query: 669  PLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQK---L 725
             L P +  P  H P        L+ L         P   +  +   +GP GP+  +   L
Sbjct: 806  -LHPQR-PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPL-HGQGPPGPHSLQAGPL 862

Query: 726  LY-----QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNL----EELPPAQ 776
            L      Q F       +G      SP+  +  T   +    +          + LPPA 
Sbjct: 863  LQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAP 922

Query: 777  ---------PTAPLPAEPAPSSDANDNELPSPEPEEL---------ICPQTTHQTAEPAE 818
                     PT P+P  PAP +  +   L  P P  +         + P ++  T  P  
Sbjct: 923  LAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 819  DNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPP 860
             +   +  +P ++ +PS  A+ P  G  Q    P PPASHPP
Sbjct: 983  AHPPPLQLMPQSQPLPSSPAQPP--GLTQSQNLPPPPASHPP 1022



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 110/448 (24%), Positives = 146/448 (32%), Gaps = 55/448 (12%)

Query: 390  PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
            P+ + N S S    Q      + P+++         S   P +   PT  P      VPP
Sbjct: 716  PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 775

Query: 450  PIPGVGKQLP--PSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATG 507
                   Q P  P   T P P      + +   +R     P P    PS   P L P TG
Sbjct: 776  QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH---PS-PHPPLQPLTG 831

Query: 508  STPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSP 567
            S  QP +    Q     PP     P GP +  AG             P L   G  PQ  
Sbjct: 832  SAGQPSAPSHAQ-----PPLHGQGPPGPHSLQAG-------------PLLQHPGP-PQPF 872

Query: 568  RKGPQTVNSSSIYSMYLQQATPPKNYQ-PAAHSALNKSVKAVYGKPVLPSGSTSPSPLPF 626
               PQ     +        A P  + Q PA+ SAL +S +    +P+       P+PL  
Sbjct: 873  GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSAL-QSQQPPREQPL------PPAPLAM 925

Query: 627  LHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRP--LSPTKLTPIVHSPLR 684
             H      TP PQ P+    K P     + P+  S   +LP P  L P       H P  
Sbjct: 926  PHIKPPPTTPIPQLPAPQAHKHPPH--LSGPSPFSMNANLPPPPALKPLSSLSTHHPPSA 983

Query: 685  YQSDADLEALRRKLANAPRP---LKKRSSITEPEGPGGPN------IQKLLYQRFNTLAG 735
            +     L    + L ++P     L +  ++  P     P        Q    Q      G
Sbjct: 984  HPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGG 1043

Query: 736  GMEGTPFYQPSPSQDFMGTLADVD--------NGNTNANGNLEELPPAQ-PTAPLPAEPA 786
                TP   PS S    G              +G + A G+   LP  Q     L     
Sbjct: 1044 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 1103

Query: 787  PSSDANDNELPSPEPEELICPQTTHQTA 814
            P S       PSPEP  +  P    Q+A
Sbjct: 1104 PESPPPPPRSPSPEPTVVDTPSHASQSA 1131



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 62/230 (26%), Positives = 81/230 (35%), Gaps = 44/230 (19%)

Query: 331  SSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWP 390
            S  Q+PL TS   A     +Q+P++ S      P + Q L  A  A             P
Sbjct: 879  SQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAM------------P 926

Query: 391  TLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVP-----FSALGPTEKPGIEIG 445
             +K   ++ +  +    A    P + G       ++ P P      S+L     P     
Sbjct: 927  HIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAH-- 984

Query: 446  KVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPA 505
              PPP+     QL P     PS     PG T S       +LP P A  P    PT L  
Sbjct: 985  --PPPL-----QLMPQSQPLPSSPAQPPGLTQSQ------NLPPPPASHP----PTGLHQ 1027

Query: 506  TGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRP 555
                PQP       Q   VP  P  PP  PP  P+  + P  P T A  P
Sbjct: 1028 VA--PQP----PFAQHPFVPGGP--PPITPPTCPSTSTPPAGPGTSAQPP 1069


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 112/462 (24%), Positives = 169/462 (36%), Gaps = 62/462 (13%)

Query: 435  GPTEKPGIEIGKVPP---PIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPS 491
            G  ++P    G+  P    I   G+  P +  T  + +       S+ + ++E S P  S
Sbjct: 587  GRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKS 646

Query: 492  AGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTV 551
                 RQR  +   T    +  S +   Q IS P SP+          + DS+  +    
Sbjct: 647  N---KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEG-----ESSDSR-SVNDEG 697

Query: 552  AIRPFLADKGSRPQSPR-KGPQTVNSSSIYSMYLQ--QATPPKNYQPAAHSALNKSVKAV 608
            +  P   D+ +R  SP    PQ   S S  S   Q  QA PP    P   +    S  A 
Sbjct: 698  SSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSS--AP 755

Query: 609  YGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPR 668
             G P LP+    P P P    S +   PQ  P +     +P+   P AP   + ++  P 
Sbjct: 756  PGTPQLPT----PGPTP----SATAVPPQGSPTASQAPNQPQ--APTAPVPHTHIQQAPA 805

Query: 669  PLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQK---L 725
             L P +  P  H P        L+ L         P   +  +   +GP GP+  +   L
Sbjct: 806  -LHPQR-PPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPL-HGQGPPGPHSLQAGPL 862

Query: 726  LY-----QRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNL----EELPPAQ 776
            L      Q F       +G      SP+  +  T   +    +          + LPPA 
Sbjct: 863  LQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAP 922

Query: 777  ---------PTAPLPAEPAPSSDANDNELPSPEPEEL---------ICPQTTHQTAEPAE 818
                     PT P+P  PAP +  +   L  P P  +         + P ++  T  P  
Sbjct: 923  LAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPS 982

Query: 819  DNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPP 860
             +   +  +P ++ +PS  A+ P  G  Q    P PPASHPP
Sbjct: 983  AHPPPLQLMPQSQPLPSSPAQPP--GLTQSQNLPPPPASHPP 1022



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 110/448 (24%), Positives = 146/448 (32%), Gaps = 55/448 (12%)

Query: 390  PTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPP 449
            P+ + N S S    Q      + P+++         S   P +   PT  P      VPP
Sbjct: 716  PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 775

Query: 450  PIPGVGKQLP--PSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATG 507
                   Q P  P   T P P      + +   +R     P P    PS   P L P TG
Sbjct: 776  QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH---PS-PHPPLQPLTG 831

Query: 508  STPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSP 567
            S  QP +    Q     PP     P GP +  AG             P L   G  PQ  
Sbjct: 832  SAGQPSAPSHAQ-----PPLHGQGPPGPHSLQAG-------------PLLQHPGP-PQPF 872

Query: 568  RKGPQTVNSSSIYSMYLQQATPPKNYQ-PAAHSALNKSVKAVYGKPVLPSGSTSPSPLPF 626
               PQ     +        A P  + Q PA+ SAL +S +    +P+       P+PL  
Sbjct: 873  GLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSAL-QSQQPPREQPL------PPAPLAM 925

Query: 627  LHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRP--LSPTKLTPIVHSPLR 684
             H      TP PQ P+    K P     + P+  S   +LP P  L P       H P  
Sbjct: 926  PHIKPPPTTPIPQLPAPQAHKHPPH--LSGPSPFSMNANLPPPPALKPLSSLSTHHPPSA 983

Query: 685  YQSDADLEALRRKLANAPRP---LKKRSSITEPEGPGGPN------IQKLLYQRFNTLAG 735
            +     L    + L ++P     L +  ++  P     P        Q    Q      G
Sbjct: 984  HPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGG 1043

Query: 736  GMEGTPFYQPSPSQDFMGTLADVD--------NGNTNANGNLEELPPAQ-PTAPLPAEPA 786
                TP   PS S    G              +G + A G+   LP  Q     L     
Sbjct: 1044 PPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEE 1103

Query: 787  PSSDANDNELPSPEPEELICPQTTHQTA 814
            P S       PSPEP  +  P    Q+A
Sbjct: 1104 PESPPPPPRSPSPEPTVVDTPSHASQSA 1131



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 62/230 (26%), Positives = 81/230 (35%), Gaps = 44/230 (19%)

Query: 331  SSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKPQSLSIASNAAHGRSKSANDGNWP 390
            S  Q+PL TS   A     +Q+P++ S      P + Q L  A  A             P
Sbjct: 879  SQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAM------------P 926

Query: 391  TLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVP-----FSALGPTEKPGIEIG 445
             +K   ++ +  +    A    P + G       ++ P P      S+L     P     
Sbjct: 927  HIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAH-- 984

Query: 446  KVPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPA 505
              PPP+     QL P     PS     PG T S       +LP P A  P    PT L  
Sbjct: 985  --PPPL-----QLMPQSQPLPSSPAQPPGLTQSQ------NLPPPPASHP----PTGLHQ 1027

Query: 506  TGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRP 555
                PQP       Q   VP  P  PP  PP  P+  + P  P T A  P
Sbjct: 1028 VA--PQP----PFAQHPFVPGGP--PPITPPTCPSTSTPPAGPGTSAQPP 1069


>gi|7657335 misshapen/NIK-related kinase isoform 1 [Homo sapiens]
          Length = 1295

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 120/528 (22%), Positives = 207/528 (39%), Gaps = 81/528 (15%)

Query: 81  RHEDSPTENSEQGGRQTQEQRTQR----NVINVPGEKRTENGVGNPRVELTLSELQDMAA 136
           R E   TE    G  +  +   +     +++NVPGE          + E   ++    A 
Sbjct: 313 RGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQE---NKSNSEAL 369

Query: 137 RQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAM 196
           +QQQQ++ QQQ       + H L Q++RR ++   E  ++++ ++R E ++ KL++    
Sbjct: 370 KQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQKEERRRVEE-QQRREREQRKLQEKEQQ 427

Query: 197 RGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSY 256
           R   D        L  E ER  A   E++QE +   L   + S++L+             
Sbjct: 428 RRLEDMQA-----LRREEERRQA---EREQEYKRKQLEEQRQSERLQR------------ 467

Query: 257 NGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRER 316
                     +L++ +  L+   Q  Q+Q  + QQQ++LL      +    + ++   + 
Sbjct: 468 ----------QLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKP 517

Query: 317 LYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSA--------GSFPVLGDPIKPQ 368
            + ++++  R        SPL+ S +  + GP   +P A           P +  P++PQ
Sbjct: 518 AWAREVE-ERTRMNKQQNSPLAKS-KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQ 575

Query: 369 SLSIASNAAH-----------GRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEG 417
                S  AH            RS+S  D     L    +S   P     A    PS  G
Sbjct: 576 EGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASH-DPDPAIPAPTATPSARG 634

Query: 418 SV-KQGTVSSQPVPFSALGPTEKPGIEI---GKVPPPIPGVGKQLPPSYGTYPSPTPLGP 473
           +V +Q +  +   P    GP+  P   +    + PP +P    Q   S  T  + +  G 
Sbjct: 635 AVIRQNSDPTSEGP----GPSPNPPAWVRPDNEAPPKVP----QRTSSIATALNTSGAGG 686

Query: 474 GSTSSLERRKEGSLPRPSAGLPSRQRPTLLPAT-GSTPQPGSSQQIQQRISVPP--SPTY 530
              +   R     L R   G    +  ++LPA+ G  PQ GS ++ +  +S  P  SP  
Sbjct: 687 SRPAQAVRASNPDLRRSDPGW--ERSDSVLPASHGHLPQAGSLERNRVGVSSKPDSSPVL 744

Query: 531 PPAGPPAFPAGDSKPELPLT-VAIRPFLADKGSRPQSPRKGPQTVNSS 577
            P          S+P  P   V ++    D+  RP  P+K     +SS
Sbjct: 745 SPGNKAKPDDHRSRPGRPADFVLLKERTLDEAPRP--PKKAMDYSSSS 790



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 28/117 (23%), Positives = 57/117 (48%), Gaps = 9/117 (7%)

Query: 60  HMMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGV 119
           H++++  ++   ++EE +   R E+      EQ  R+ QE+  QR + ++   +R E   
Sbjct: 389 HLLHQRQRRIEEQKEERR---RVEEQQRREREQ--RKLQEKEQQRRLEDMQALRREEERR 443

Query: 120 GNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKL 176
              R +    E +     +Q+Q E  Q+ L  +   L  L+QQ+++QQ    + ++L
Sbjct: 444 QAEREQ----EYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 67.8 bits (164), Expect = 5e-11
 Identities = 113/470 (24%), Positives = 154/470 (32%), Gaps = 88/470 (18%)

Query: 308  KRISELRERLYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSAGSFPVLGDPIKP 367
            +R++ LR         L  +  +SS  +P   SG      P I  P    F +   P  P
Sbjct: 614  ERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSG------PQILTPLGDRFVIPPHPKVP 667

Query: 368  QSLSIASNAAHGRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQ 427
               S                  P  K  S +   P   A A    P    S    +  S 
Sbjct: 668  APFSP-----------------PPSKPRSPNPAAPALAAPAVVPGPV---STTDASPQSP 707

Query: 428  PVPFSALGPT-EKPGIEIGKVPPPIPGVGKQLPPSYGTYPSPTPL------GPGSTSSLE 480
            P P + L P  E P I   + PPP P      PPSY   P PT         P ++ + E
Sbjct: 708  PTPQTTLTPLQESPVISKDQSPPPSP------PPSYHPPPPPTKKPEVVVEAPSASETAE 761

Query: 481  RR-KEGSLPRPSAGLPSRQR-----------------------PTLLPATGSTPQPGSSQ 516
               ++ + P P    P  Q                        P+  P   S+P   SS 
Sbjct: 762  EPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSS 821

Query: 517  QIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNS 576
                +I  P SP  PPA P   PA  +   +       P    KG  P     G   V  
Sbjct: 822  ATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTP 881

Query: 577  SSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLP----------- 625
            S +  + L+    P     A   AL  S      +  L SG  SP P P           
Sbjct: 882  SLLQMVRLRSVGAPGG---APTPALGPSAPQKPLRRAL-SGRASPVPAPSSGLHAAVRLK 937

Query: 626  --FLHGSLSTGTPQPQPPSESTEKEPEQDGPAAP---ADGSTVESLPRPLSP---TKLTP 677
               L  S    + QP  P E+  + P+     A    + GS    L RP+SP     L  
Sbjct: 938  ACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPVSPETQADLQR 997

Query: 678  IVHSPLRYQSDADLEALRRKLANAPRPLKKRSS--ITEPEGPGGPNIQKL 725
             + + LR  S+       +K   AP P+ ++ S  +  P  P  P  + L
Sbjct: 998  NLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPASPSYPRAEPL 1047



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 128/556 (23%), Positives = 193/556 (34%), Gaps = 86/556 (15%)

Query: 352 VPSAGSFPVLGDPIKPQSLSIASNA---AHGRSKSANDGNWPTLKQNSSSSVKPVQVAGA 408
           V S G F  +  P +P+S   +S++   +H +S      +  TL     S  +P     +
Sbjct: 390 VRSLGRFSSVSSP-QPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPESSTAS 448

Query: 409 DWKDPSVEGSVKQGTVS-------SQPVPFSALGPTEKPGIEIGKV--PPPIPGVGKQLP 459
           +   P  +G   +G+ S       S  +   + G      + + K+  PPP P    +  
Sbjct: 449 NSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPP----RRT 504

Query: 460 PSYGTYPSPTPLGP-GSTSSLERRKEGSLPRP-----SAGLPSRQRPTLLPATGSTP--Q 511
            S        P GP G     ER+++  LPRP     S G  +   P   PA    P   
Sbjct: 505 HSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPN-PANSWVPGLS 563

Query: 512 PGSSQQ---IQQRISVPPS--------PTYPP---AGPPAFPAGDSKPELPLTVAIRP-- 555
           PG S++     +R   P S        PT PP   AGPPA P     P+     ++R   
Sbjct: 564 PGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPG 623

Query: 556 --------FLADKGSRPQ-SPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVK 606
                    L    S P  S R GPQ +       +       P  + P      + +  
Sbjct: 624 ASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPA 683

Query: 607 AVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESL 666
           A    P L + +  P P+     S +  +PQ  PP+  T   P Q+ P    D S   S 
Sbjct: 684 A----PALAAPAVVPGPV-----STTDASPQ-SPPTPQTTLTPLQESPVISKDQSPPPSP 733

Query: 667 PR----PLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNI 722
           P     P  PTK   +V         A+           P P  +   ++  + P     
Sbjct: 734 PPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPP--- 790

Query: 723 QKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP-L 781
           ++  +   +    G  G+P    SP+       A            L+  PP  P  P  
Sbjct: 791 EEAFFSVASPEPAGPSGSPELVSSPAASSSSATA------------LQIQPPGSPDPPPA 838

Query: 782 PAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAP 841
           P  PAP+S A  +    P+ E + C   +     P ED    + T    + +      AP
Sbjct: 839 PPAPAPASSAPGHVAKLPQKEPVGC---SKGGGPPREDVGAPLVTPSLLQMVRLRSVGAP 895

Query: 842 --SPGEEQVPPAPLPP 855
             +P     P AP  P
Sbjct: 896 GGAPTPALGPSAPQKP 911



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 135/592 (22%), Positives = 202/592 (34%), Gaps = 96/592 (16%)

Query: 327 VNGTSSPQSPLSTSGRVAAVGPYIQ--VPSAGSFPVLGDPIKPQSLSIASNAAHGRSK-- 382
           + G + P  PLS +  ++    Y+   +P A    VL   +   +L   S     R    
Sbjct: 328 LTGGAGPAEPLSPAMSISPQATYLSKLIPHA----VLPPTVDVVALGRCSLRTLSRCSLH 383

Query: 383 SANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEGSVKQGTVSSQPVPFSALGPTE-KPG 441
           SA+  +  +L + SS S    +         +   S    T+ S     S+ G +E +P 
Sbjct: 384 SASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGSTLSSKGGSEGQPE 443

Query: 442 IEIGK---VPPPIPGVGKQLPPSYGTYPSPTPLGPGSTSSLERRKEGSLPRPSAGLPSRQ 498
                   VPPP  G G+  P    T  +        + +L  R  G L   S  L   +
Sbjct: 444 SSTASNSVVPPPQGGSGRGSPSGGSTAEA--------SDTLSIRSSGQLSGRSVSLRKLK 495

Query: 499 RPTLLPATGSTPQPGSSQQIQQR-ISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIR--- 554
           RP         P P  +  + QR ++VP  P     G P  P    +P+LP         
Sbjct: 496 RPP--------PPPRRTHSLHQRGLAVPDGPL----GLPPKPERKQQPQLPRPPTTGGSE 543

Query: 555 ----------------PFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQAT-PPKNYQ-PA 596
                           P L+  GSR + PR   +T++ SS YS      T PPK    P 
Sbjct: 544 GAGAAPCPPNPANSWVPGLSPGGSR-RPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPP 602

Query: 597 AHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQ----PQPPSESTEKEPEQD 652
           A     +  K      +   G++  S L  L  S S   P     PQ  +   ++     
Sbjct: 603 ASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPP 662

Query: 653 GPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSIT 712
            P  PA  S   S PR  SP    P + +P                A  P P+    +  
Sbjct: 663 HPKVPAPFSPPPSKPR--SPNPAAPALAAP----------------AVVPGPVSTTDA-- 702

Query: 713 EPEGPGGPNIQKLLYQRFNTLAGGMEGTP-----FYQPSPSQDFMGTLADVDNGNTNANG 767
            P+ P  P       Q    ++      P     ++ P P       + +  + +  A  
Sbjct: 703 SPQSPPTPQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETA-- 760

Query: 768 NLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATV 827
              E P   P  P P  PAP  + + +    P PEE      + + A P+   +  + + 
Sbjct: 761 ---EEPLQDPNWPPPPPPAPE-EQDLSMADFPPPEEAFFSVASPEPAGPS--GSPELVSS 814

Query: 828 PTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTG 879
           P      +   +   PG    PPAP  PA   PA+S       K P  E  G
Sbjct: 815 PAASSSSATALQIQPPGSPDPPPAPPAPA---PASSAPGHV-AKLPQKEPVG 862



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 118/530 (22%), Positives = 174/530 (32%), Gaps = 91/530 (17%)

Query: 411  KDPSVEGSVKQGTVSSQPVPFSALGPTEKPGIEIGKVPPPIPGVGKQLPPSYGTYPS--- 467
            + P+  GS   G     P P ++  P   PG    + PP  P   + L PS G Y S   
Sbjct: 535  RPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGS--RRPPRSPE--RTLSPSSG-YSSQSG 589

Query: 468  -PT---------PLGPGSTSSLERRKEGSLPRPSAGLPSRQRPTLLPATGSTPQPGSSQQ 517
             PT         P  PG     +  +  SL  P A + S        ++   P   S  Q
Sbjct: 590  TPTLPPKGLAGPPASPGKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQ 649

Query: 518  IQ----QRISVPPSPTYP-PAGPPAFPAGDSKPELPLTVA---IRPFLADKGSRPQSPRK 569
            I      R  +PP P  P P  PP        P  P   A   +   ++   + PQSP  
Sbjct: 650  ILTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPT 709

Query: 570  GPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHG 629
               T+       +  +  +PP +  P+ H     + K         +  T+  PL     
Sbjct: 710  PQTTLTPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQ---- 765

Query: 630  SLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDA 689
                  P P PP+   +     D P  P +     + P P  P+    +V SP    S A
Sbjct: 766  --DPNWPPPPPPAPEEQDLSMADFPP-PEEAFFSVASPEPAGPSGSPELVSSPAASSSSA 822

Query: 690  DLEALR--------------RKLANAPR-----PLKKRSSITEPEGP-----GGPNIQKL 725
                ++                 ++AP      P K+    ++  GP     G P +   
Sbjct: 823  TALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTPS 882

Query: 726  LYQRFNTLAGGMEG---TPFYQPSPSQD-----FMGTLADVDNGNTNANGNL-------- 769
            L Q     + G  G   TP   PS  Q        G  + V   ++  +  +        
Sbjct: 883  LLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKACSLA 942

Query: 770  --EELPPAQPTAPLPAEPAP--SSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVA 825
              E L  AQP  P  AEP P  S  +  + + S    +L   +    + E   D   N+ 
Sbjct: 943  ASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERPV--SPETQADLQRNL- 999

Query: 826  TVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNS 875
                       VAE  S  E++ P AP      PP  +      +  P S
Sbjct: 1000 -----------VAELRSISEQRPPQAPKKSPKAPPPVARKPSVGVPPPAS 1038



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 91/439 (20%), Positives = 146/439 (33%), Gaps = 74/439 (16%)

Query: 495 PSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIR 554
           P   RP  L   G T   G ++ +   +S+ P  TY        P     P + +    R
Sbjct: 315 PPLTRPMSLAVPGLTGGAGPAEPLSPAMSISPQATYL---SKLIPHAVLPPTVDVVALGR 371

Query: 555 PFLADKGSRPQSPRKGPQTVNS----SSIYSMYLQQATPPKNYQPAAHSALNKSV----- 605
             L    SR       P +V S    SS+ S   +   P  +    +HS  + ++     
Sbjct: 372 CSLRTL-SRCSLHSASPASVRSLGRFSSVSSPQPRSRHPSSSSDTWSHSQSSDTIVSDGS 430

Query: 606 --KAVYGKPVLPSGST-SPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGST 662
              +  G    P  ST S S +P   G    G+P     +E+++    +          +
Sbjct: 431 TLSSKGGSEGQPESSTASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVS 490

Query: 663 VESLPRPLSPTKLTPIVHSPLRYQSDADL----EALRRKLANAPR--------------- 703
           +  L RP  P + T  +H       D  L    +  R++    PR               
Sbjct: 491 LRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPC 550

Query: 704 PLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGG---MEGTPFYQPS-------------- 746
           P    +S      PGG        +R  + + G     GTP   P               
Sbjct: 551 PPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQP 610

Query: 747 PSQDFMGTL----ADVDNGNTNANGNLEELPPAQPTAPL--------------PAEPAP- 787
           P  + + +L    A V +  T+   +  +  P+  + P               P  PAP 
Sbjct: 611 PKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPAPF 670

Query: 788 SSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQ 847
           S   +    P+P    L  P        P    + +  + PT +   +P+ E+P   ++Q
Sbjct: 671 SPPPSKPRSPNPAAPALAAPAV---VPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQ 727

Query: 848 VPPAPLPPASHPPATSTNK 866
            PP   PP+ HPP   T K
Sbjct: 728 SPPPSPPPSYHPPPPPTKK 746


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 87/386 (22%), Positives = 132/386 (34%), Gaps = 54/386 (13%)

Query: 490  PSAGLPSRQRPTLLPATGSTPQPGSSQQIQQRISVPPSPTYPPAGPPAFPAGDSKPELPL 549
            P+  + + + P       STP+  +S      +  P  PT P A  P        PE P 
Sbjct: 977  PATTVHAPEEPDTAAVRVSTPEEPASPAAA--VPTPEEPTSPAAAVPT-------PEEPT 1027

Query: 550  TVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPKNYQPAAHSALNKSVKAVY 609
            + A      ++ + P +    P+   S +      ++ T P    P      + +  A  
Sbjct: 1028 SPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPA--AAV 1085

Query: 610  GKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQDGPAAPADGSTVESLPRP 669
              P  P+   +  P P    S +   P P+ P+      P  + PA+PA      ++P P
Sbjct: 1086 PTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPA-----AAVPTP 1140

Query: 670  LSPTKLTPIVHSPLRYQSDADL----EALRRKLANAPRPLKKRS------SITEPEGPGG 719
              P    P V +P    S A      E      A  P P +  S      ++ EP  P  
Sbjct: 1141 EEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAA 1200

Query: 720  PNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTA 779
                                TP    +  ++F    A V      A+       P +PT+
Sbjct: 1201 S-----------------VPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTS 1243

Query: 780  PLPAEPAPSSDANDNELPSPEPEELICPQ----TTHQTAEPA------EDNNNNVATVPT 829
            P  A P    +   +      PEEL  P     T  + A PA      E+  +  A VPT
Sbjct: 1244 PAAAVPT-LEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPT 1302

Query: 830  TEQIPSPVAEAPSPGEEQVPPAPLPP 855
             E    P A  P+P    +P A +PP
Sbjct: 1303 PEVAAIPAASVPTPEVPAIPAAAVPP 1328



 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 78/346 (22%), Positives = 119/346 (34%), Gaps = 41/346 (11%)

Query: 532  PAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSIYSMYLQQATPPK 591
            P GP         PE P T A+R    ++ + P +    P+   S +      ++ T P 
Sbjct: 971  PEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPA 1030

Query: 592  NYQPAAHSALNKSVKAVYGKPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSESTEKEPEQ 651
               P      + +  A    P  P+   +  P P    S +   P P+ P+      P  
Sbjct: 1031 AAVPPPEEPTSPA--AAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTP 1088

Query: 652  DGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSI 711
            + P +PA      ++P P  PT     V +P    S A        +     P    +++
Sbjct: 1089 EEPTSPA-----AAVPTPEEPTSPAAAVPTPEEPASPA------AAVPTPEEPASPAAAV 1137

Query: 712  TEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSP---------SQDFMGTLADVDNGN 762
              PE P  P       +   + A  +  TP    SP         S  F   +A ++   
Sbjct: 1138 PTPEEPAFPAPAVPTPEESASAAVAVP-TPEESASPAAAVPTPAESASFAAVVATLEEPT 1196

Query: 763  TNANG---------NLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQT 813
            + A            LEE      + P   EPA  + A  N      PEE   P     T
Sbjct: 1197 SPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSN------PEEPTSPAAAVPT 1250

Query: 814  AEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHP 859
             E   +  ++ A V T E++ SP A  P+P E   P A +     P
Sbjct: 1251 LE---EPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEP 1293



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 82/349 (23%), Positives = 115/349 (32%), Gaps = 57/349 (16%)

Query: 520  QRISVPPSPTYPPAGPPAFPAGDSKPELPLTVAIRPFLADKGSRPQSPRKGPQTVNSSSI 579
            +R +VP      P G  A  A  S  E    VA    +  +G    +    P+    +  
Sbjct: 905  ERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAA--ITQEGMSAVAGFS-PEWAALAIT 961

Query: 580  YSMYLQQATPPKNYQPAA--HSALNKSVKAV-YGKPVLPSGSTSPSPLPFLHGSLSTGTP 636
              +  +  TP     PA   H+       AV    P  P+   +  P P    S +   P
Sbjct: 962  VPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVP 1021

Query: 637  QPQPPSESTEKEPEQDGPAAPADGSTVESLPRPLSPTKLTPIVHSPLRYQSDADLEALRR 696
             P+ P+      P  + P +PA      ++P P  PT     V +P    S A       
Sbjct: 1022 TPEEPTSPAAAVPPPEEPTSPA-----AAVPTPEEPTSPAAAVPTPEEPTSPA------A 1070

Query: 697  KLANAPRPLKKRSSITEPEGPGGPNIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLA 756
             +     P    +++  PE P  P                   TP    SP+        
Sbjct: 1071 AVPTPEEPTSPAAAVPTPEEPTSP--------------AAAVPTPEEPTSPAA------- 1109

Query: 757  DVDNGNTNANGNLEELPPAQPTAPLPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEP 816
                    A    EE  PA P A +P    P+S A       P PEE   P     T E 
Sbjct: 1110 --------AVPTPEE--PASPAAAVPTPEEPASPA----AAVPTPEEPAFPAPAVPTPE- 1154

Query: 817  AEDNNNNVATVPTTEQIPSPVAEAPSPGEEQVPPAPLPPASHP--PATS 863
              ++ +    VPT E+  SP A  P+P E     A +     P  PA S
Sbjct: 1155 --ESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAAS 1201



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 50/200 (25%), Positives = 71/200 (35%), Gaps = 22/200 (11%)

Query: 669  PLSPTKLTPIVHSPLRYQSDADLEALRRKLANAPRPLKKRSSITEPEGPGGPNIQKLLYQ 728
            P  P      VH+P     + D  A+R  ++    P    +++  PE P  P       +
Sbjct: 971  PEGPVTPATTVHAP----EEPDTAAVR--VSTPEEPASPAAAVPTPEEPTSPAAAVPTPE 1024

Query: 729  RFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAPLPAEPAPS 788
               + A  +         P ++     A V       +       P +PT+P  A P P 
Sbjct: 1025 EPTSPAAAVP--------PPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPE 1076

Query: 789  SDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEAPSPGEEQV 848
               +      P PEE   P     T E   +  +  A VPT E+  SP A  P+P E   
Sbjct: 1077 EPTSP-AAAVPTPEEPTSPAAAVPTPE---EPTSPAAAVPTPEEPASPAAAVPTPEEPAS 1132

Query: 849  P----PAPLPPASHPPATST 864
            P    P P  PA   PA  T
Sbjct: 1133 PAAAVPTPEEPAFPAPAVPT 1152



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 60/259 (23%), Positives = 89/259 (34%), Gaps = 41/259 (15%)

Query: 611  KPVLPSGSTSPSPLPFLHGSLSTGTPQPQPPSES----TEKEPEQDGPAAPADGSTVESL 666
            K V  +G+T P         L    P  Q PS +    T K+       +P +G+++ ++
Sbjct: 812  KQVTKAGNTEPV--------LEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAV 863

Query: 667  PRPLSPT---KLTPIVHSPLRYQSDADLEA--LRRKLANAP-RPLKKRSSITEPEGPGGP 720
            P P        L P  H  +   S   LE   +     +AP R      +++ PEG    
Sbjct: 864  PAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVPEGTAA- 922

Query: 721  NIQKLLYQRFNTLAGGMEGTPFYQPSPSQDFMGTLADVDNGNTNANGNLEELPPAQPTAP 780
                        ++   E  P    + +Q+ M  +A          G   E      T P
Sbjct: 923  ---------VAAVSSPEETAPAVAAAITQEGMSAVA----------GFSPEWAALAITVP 963

Query: 781  LPAEPAPSSDANDNELPSPEPEELICPQTTHQTAEPAEDNNNNVATVPTTEQIPSPVAEA 840
            +  E                PEE   P T        E+  +  A VPT E+  SP A  
Sbjct: 964  ITEEDGTPEGPVTPATTVHAPEE---PDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAV 1020

Query: 841  PSPGEEQVPPAPLPPASHP 859
            P+P E   P A +PP   P
Sbjct: 1021 PTPEEPTSPAAAVPPPEEP 1039


>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
            sapiens]
          Length = 782

 Score = 67.0 bits (162), Expect = 9e-11
 Identities = 48/147 (32%), Positives = 72/147 (48%), Gaps = 19/147 (12%)

Query: 884  VRFNPLALLLDASLEGEFDLVQRIIYEVE-------DPSKP----------NDEGITPLH 926
            VRF   A  L A   G+ D  + ++   +       DP+ P          N +GI+ LH
Sbjct: 47   VRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALH 106

Query: 927  NAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAIFASTIS 986
             A    +  +V+FL++ G  VN AD++GWTPLH AASC  + + + L+  GA I A+  S
Sbjct: 107  QACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI-AAVNS 165

Query: 987  DIETAADKCE-EMEEGYIQCSQFLYGV 1012
            D +   D  E +  EG ++      GV
Sbjct: 166  DGDLPLDLAESDAMEGLLKAEIARRGV 192



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 37/124 (29%), Positives = 59/124 (47%), Gaps = 20/124 (16%)

Query: 840 APSPGEEQVPPAPLPPASHPPATSTNKRTNLKKPNSERTGHGLRVRFNPLALLLDASLEG 899
           A  PG    P A L PA+ PPA +    TN                 + ++ L  A ++ 
Sbjct: 73  AADPG----PGAELDPAAPPPARAVLDSTNA----------------DGISALHQACIDE 112

Query: 900 EFDLVQRIIYEVEDPSKPNDEGITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLH 959
             ++V+ ++ +    ++ ++EG TPLH A   G+  I ++LL  G N+ A +SDG  PL 
Sbjct: 113 NLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLD 172

Query: 960 CAAS 963
            A S
Sbjct: 173 LAES 176



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 29/96 (30%), Positives = 42/96 (43%), Gaps = 4/96 (4%)

Query: 921  GITPLHNAVCAGHHHIVKFLLDFGVNVNAADSDGWTPLHCAASCNSVHLCKQLVESGAAI 980
            G + LH A   G+  +++ LL  G +    D DGWTPLH AA       C+ L E G  +
Sbjct: 227  GASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGM 286

Query: 981  FASTISDIETAADKCEEMEEGYIQCSQFLYGVQEKL 1016
             + T          C+  +E  +   + L   QE L
Sbjct: 287  DSLT----HAGQRPCDLADEEVLSLLEELARKQEDL 318


>gi|24850117 misshapen/NIK-related kinase isoform 2 [Homo sapiens]
          Length = 1303

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 110/494 (22%), Positives = 195/494 (39%), Gaps = 81/494 (16%)

Query: 81  RHEDSPTENSEQGGRQTQEQRTQR----NVINVPGEKRTENGVGNPRVELTLSELQDMAA 136
           R E   TE    G  +  +   +     +++NVPGE          + E   ++    A 
Sbjct: 313 RGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQE---NKSNSEAL 369

Query: 137 RQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKLQKLKERVEAQENKLKKIRAM 196
           +QQQQ++ QQQ       + H L Q++RR ++   E  ++++ ++R E ++ KL++    
Sbjct: 370 KQQQQLQQQQQRDPEAHIK-HLLHQRQRRIEEQKEERRRVEE-QQRREREQRKLQEKEQQ 427

Query: 197 RGQVDYSKIMNGNLSAEIERFSAMFQEKKQEVQTAILRVDQLSQQLEDLKKGKLNGFQSY 256
           R   D        L  E ER  A   E++QE +   L   + S++L+             
Sbjct: 428 RRLEDMQA-----LRREEERRQA---EREQEYKRKQLEEQRQSERLQR------------ 467

Query: 257 NGKLTGPAAVELKRLYQELQIRNQLNQEQNSKLQQQKELLNKRNMEVAMMDKRISELRER 316
                     +L++ +  L+   Q  Q+Q  + QQQ++LL      +    + ++   + 
Sbjct: 468 ----------QLQQEHAYLKSLQQQQQQQQLQKQQQQQLLPGDRKPLYHYGRGMNPADKP 517

Query: 317 LYGKKIQLNRVNGTSSPQSPLSTSGRVAAVGPYIQVPSA--------GSFPVLGDPIKPQ 368
            + ++++  R        SPL+ S +  + GP   +P A           P +  P++PQ
Sbjct: 518 AWAREVE-ERTRMNKQQNSPLAKS-KPGSTGPEPPIPQASPGPPGPLSQTPPMQRPVEPQ 575

Query: 369 SLSIASNAAH-----------GRSKSANDGNWPTLKQNSSSSVKPVQVAGADWKDPSVEG 417
                S  AH            RS+S  D     L    +S   P     A    PS  G
Sbjct: 576 EGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASH-DPDPAIPAPTATPSARG 634

Query: 418 SV-KQGTVSSQPVPFSALGPTEKPGIEI---GKVPPPIPGVGKQLPPSYGTYPSPTPLGP 473
           +V +Q +  +   P    GP+  P   +    + PP +P    Q   S  T  + +  G 
Sbjct: 635 AVIRQNSDPTSEGP----GPSPNPPAWVRPDNEAPPKVP----QRTSSIATALNTSGAGG 686

Query: 474 GSTSSLERRKEGSLPRPSAGLPSRQRPTLLPAT-GSTPQPGSSQQIQQRISVPPSPTYPP 532
              +   R     L R   G    +  ++LPA+ G  PQ GS ++ +  +S     + P 
Sbjct: 687 SRPAQAVRASNPDLRRSDPGW--ERSDSVLPASHGHLPQAGSLERNRVGVS-----SKPD 739

Query: 533 AGPPAFPAGDSKPE 546
           + P   P   +KP+
Sbjct: 740 SSPVLSPGNKAKPD 753



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 28/117 (23%), Positives = 57/117 (48%), Gaps = 9/117 (7%)

Query: 60  HMMYEHLQKWGPRREEVKFFLRHEDSPTENSEQGGRQTQEQRTQRNVINVPGEKRTENGV 119
           H++++  ++   ++EE +   R E+      EQ  R+ QE+  QR + ++   +R E   
Sbjct: 389 HLLHQRQRRIEEQKEERR---RVEEQQRREREQ--RKLQEKEQQRRLEDMQALRREEERR 443

Query: 120 GNPRVELTLSELQDMAARQQQQIENQQQMLVAKEQRLHFLKQQERRQQQSISENEKL 176
              R +    E +     +Q+Q E  Q+ L  +   L  L+QQ+++QQ    + ++L
Sbjct: 444 QAEREQ----EYKRKQLEEQRQSERLQRQLQQEHAYLKSLQQQQQQQQLQKQQQQQL 496


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.129    0.377 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,940,677
Number of Sequences: 37866
Number of extensions: 3225763
Number of successful extensions: 37526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 651
Number of HSP's successfully gapped in prelim test: 2147
Number of HSP's that attempted gapping in prelim test: 17858
Number of HSP's gapped (non-prelim): 14129
length of query: 1090
length of database: 18,247,518
effective HSP length: 113
effective length of query: 977
effective length of database: 13,968,660
effective search space: 13647380820
effective search space used: 13647380820
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press