Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 12025678
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12025678 actinin, alpha 4 [Homo sapiens]
(911 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12025678 actinin, alpha 4 [Homo sapiens] 1837 0.0
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 1570 0.0
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 1557 0.0
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 1538 0.0
gi|4501893 actinin, alpha 2 [Homo sapiens] 1422 0.0
gi|4557241 actinin, alpha 3 [Homo sapiens] 1390 0.0
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 449 e-126
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 449 e-126
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 444 e-124
gi|67782321 spectrin beta isoform a [Homo sapiens] 439 e-123
gi|67782319 spectrin beta isoform b [Homo sapiens] 439 e-123
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 409 e-114
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 338 2e-92
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 290 5e-78
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 290 5e-78
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 253 7e-67
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 251 3e-66
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 250 5e-66
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 250 5e-66
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 250 5e-66
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 250 5e-66
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 250 5e-66
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 250 5e-66
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 246 7e-65
gi|221316624 dystonin isoform 4 [Homo sapiens] 243 5e-64
gi|221316622 dystonin isoform 3 [Homo sapiens] 243 5e-64
gi|221316618 dystonin isoform 2 [Homo sapiens] 243 5e-64
gi|34577047 dystonin isoform 1 [Homo sapiens] 243 5e-64
gi|33188445 microfilament and actin filament cross-linker protei... 233 5e-61
gi|110611228 utrophin [Homo sapiens] 215 1e-55
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 1837 bits (4759), Expect = 0.0
Identities = 911/911 (100%), Positives = 911/911 (100%)
Query: 1 MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC 60
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC
Sbjct: 1 MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWC 60
Query: 61 NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA 120
NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA
Sbjct: 61 NSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIA 120
Query: 121 SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY 180
SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY
Sbjct: 121 SKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY 180
Query: 181 KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM 240
KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM
Sbjct: 181 KNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKM 240
Query: 241 LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK 300
LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK
Sbjct: 241 LDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEK 300
Query: 301 LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL 360
LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL
Sbjct: 301 LASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTL 360
Query: 361 QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ 420
QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ
Sbjct: 361 QTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ 420
Query: 421 KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL 480
KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL
Sbjct: 421 KASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL 480
Query: 481 NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF 540
NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF
Sbjct: 481 NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF 540
Query: 541 NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES 600
NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES
Sbjct: 541 NNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAES 600
Query: 601 NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV 660
NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV
Sbjct: 601 NHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANV 660
Query: 661 VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF 720
VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF
Sbjct: 661 VGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIF 720
Query: 721 DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD 780
DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD
Sbjct: 721 DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKD 780
Query: 781 HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT 840
HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT
Sbjct: 781 HGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETT 840
Query: 841 DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS 900
DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS
Sbjct: 841 DTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKS 900
Query: 901 FSTALYGESDL 911
FSTALYGESDL
Sbjct: 901 FSTALYGESDL 911
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 1570 bits (4065), Expect = 0.0
Identities = 765/882 (86%), Positives = 821/882 (93%)
Query: 30 DYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89
DYM E+DWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENI+EDFRDGLKLMLLLE
Sbjct: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
Query: 90 VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149
VISGERL KPERGKMRVHKI+NVNKALDFIASKGVKLVSIGAEEIVDGN KMTLGMIWTI
Sbjct: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
Query: 150 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL 209
ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVN+QNFHISWKDGL F ALIHRHRPEL
Sbjct: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
Query: 210 IEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFS 269
I+Y KLRKDDP+TNLN AF+VAEKYLDIPKMLDAEDIV TARPDEKAIMTYVSSFYHAFS
Sbjct: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
Query: 270 GAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQ 329
GAQKAETAANRICKVLAVNQENE LMEDYEKLASDLLEWIRRTIPWLE+RVP+ T+ MQ
Sbjct: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
Query: 330 QKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389
QKLEDFRDYRR+HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG+MVSDINN W
Sbjct: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
Query: 390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI 449
LEQ EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML+ +DYETATLS+I
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
Query: 450 KALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLT 509
KAL++KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS +VN RCQKICDQWD LG+LT
Sbjct: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
Query: 510 HSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISA 569
RREALE+TEK LE IDQL+LEYAKRAAPFNNWME AMEDLQD FIVHTIEEI+GL +A
Sbjct: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
H+QFK+TLPDAD+ER AIL IH E +I ++ H+ ++G+NPYTT+TPQ IN KW+ V+QL
Sbjct: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSH 689
VP+RD AL EE ++QQ NE LR+QF +QANV+GPWIQTKMEEIGRISIEM+GTLEDQLSH
Sbjct: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
Query: 690 LKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 749
L+QYE+SIV+YKP +D LE HQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE
Sbjct: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
Query: 750 VENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEA 809
VENQILTRDAKGISQEQM EFRASFNHFD+DH G LGPEEFKACLISLGYD+ ND QGEA
Sbjct: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEA 790
Query: 810 EFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRR 869
EF RIMS+VDPN G+VTFQAFIDFMSRET DTDTADQV+ASFK+LAGDKN+IT +ELRR
Sbjct: 791 EFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRR 850
Query: 870 ELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911
ELPPDQAEYCIARMAPY GPD+VPGALDY SFSTALYGESDL
Sbjct: 851 ELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 1557 bits (4032), Expect = 0.0
Identities = 765/904 (84%), Positives = 821/904 (90%), Gaps = 22/904 (2%)
Query: 30 DYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89
DYM E+DWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENI+EDFRDGLKLMLLLE
Sbjct: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
Query: 90 VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149
VISGERL KPERGKMRVHKI+NVNKALDFIASKGVKLVSIGAEEIVDGN KMTLGMIWTI
Sbjct: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
Query: 150 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL 209
ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVN+QNFHISWKDGL F ALIHRHRPEL
Sbjct: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
Query: 210 IEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFS 269
I+Y KLRKDDP+TNLN AF+VAEKYLDIPKMLDAEDIV TARPDEKAIMTYVSSFYHAFS
Sbjct: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
Query: 270 GAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQ 329
GAQKAETAANRICKVLAVNQENE LMEDYEKLASDLLEWIRRTIPWLE+RVP+ T+ MQ
Sbjct: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
Query: 330 QKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389
QKLEDFRDYRR+HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG+MVSDINN W
Sbjct: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
Query: 390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI 449
LEQ EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML+ +DYETATLS+I
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
Query: 450 KALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLT 509
KAL++KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS +VN RCQKICDQWD LG+LT
Sbjct: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
Query: 510 HSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISA 569
RREALE+TEK LE IDQL+LEYAKRAAPFNNWME AMEDLQD FIVHTIEEI+GL +A
Sbjct: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
H+QFK+TLPDAD+ER AIL IH E +I ++ H+ ++G+NPYTT+TPQ IN KW+ V+QL
Sbjct: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSH 689
VP+RD AL EE ++QQ NE LR+QF +QANV+GPWIQTKMEEIGRISIEM+GTLEDQLSH
Sbjct: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
Query: 690 LKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 749
L+QYE+SIV+YKP +D LE HQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE
Sbjct: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
Query: 750 VENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQ--- 806
VENQILTRDAKGISQEQM EFRASFNHFD+DH G LGPEEFKACLISLGYD+ ND Q
Sbjct: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKT 790
Query: 807 -------------------GEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQ 847
GEAEF RIMS+VDPN G+VTFQAFIDFMSRET DTDTADQ
Sbjct: 791 GMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQ 850
Query: 848 VIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYG 907
V+ASFK+LAGDKN+IT +ELRRELPPDQAEYCIARMAPY GPD+VPGALDY SFSTALYG
Sbjct: 851 VMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYG 910
Query: 908 ESDL 911
ESDL
Sbjct: 911 ESDL 914
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 1538 bits (3982), Expect = 0.0
Identities = 752/882 (85%), Positives = 814/882 (92%), Gaps = 5/882 (0%)
Query: 30 DYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89
DYM E+DWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENI+EDFRDGLKLMLLLE
Sbjct: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
Query: 90 VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149
VISGERL KPERGKMRVHKI+NVNKALDFIASKGVKLVSIGAEEIVDGN KMTLGMIWTI
Sbjct: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
Query: 150 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL 209
ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVN+QNFHISWKDGL F ALIHRHRPEL
Sbjct: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
Query: 210 IEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFS 269
I+Y KLRKDDP+TNLN AF+VAEKYLDIPKMLDAEDIV TARPDEKAIMTYVSSFYHAFS
Sbjct: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
Query: 270 GAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQ 329
GAQKAETAANRICKVLAVNQENE LMEDYEKLASDLLEWIRRTIPWLE+RVP+ T+ MQ
Sbjct: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
Query: 330 QKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389
QKLEDFRDYRR+HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG+MVSDINN W
Sbjct: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
Query: 390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI 449
LEQ EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML+ +DYETATLS+I
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
Query: 450 KALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLT 509
KAL++KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS +VN RCQKICDQWD LG+LT
Sbjct: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
Query: 510 HSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISA 569
RREALE+TEK LE IDQL+LEYAKRAAPFNNWME AMEDLQD FIVHTIEEI+GL +A
Sbjct: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
H+QFK+TLPDAD+ER AIL IH E +I ++ H+ ++G+NPYTT+TPQ IN KW+ V+QL
Sbjct: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSH 689
VP+RD AL EE ++QQ NE LR+QF +QANV+GPWIQTKMEEIGRISIEM+GTLEDQLSH
Sbjct: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
Query: 690 LKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 749
L+QYE+SIV+YKP +D LE HQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE
Sbjct: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
Query: 750 VENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEA 809
VENQILTRDAKGISQEQM EFRASFNHFD+ G + ++F+ACLIS+GY++ GEA
Sbjct: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNM-----GEA 785
Query: 810 EFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRR 869
EF RIMS+VDPN G+VTFQAFIDFMSRET DTDTADQV+ASFK+LAGDKN+IT +ELRR
Sbjct: 786 EFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRR 845
Query: 870 ELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911
ELPPDQAEYCIARMAPY GPD+VPGALDY SFSTALYGESDL
Sbjct: 846 ELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 887
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 1422 bits (3680), Expect = 0.0
Identities = 688/882 (78%), Positives = 785/882 (89%), Gaps = 5/882 (0%)
Query: 30 DYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89
+YM QE++WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENI+EDFR+GLKLMLLLE
Sbjct: 18 EYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 77
Query: 90 VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149
VISGERLPKP+RGKMR HKI NVNKALD+IASKGVKLVSIGAEEIVDGN KMTLGMIWTI
Sbjct: 78 VISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 137
Query: 150 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL 209
ILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVN+QNFH SWKDGL ALIHRHRP+L
Sbjct: 138 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDL 197
Query: 210 IEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFS 269
I+Y KL KDDP+ N+N A E+AEK+LDIPKMLDAEDIVNT +PDE+AIMTYVS FYHAF+
Sbjct: 198 IDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA 257
Query: 270 GAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQ 329
GA++AETAANRICKVLAVNQENE LME+YE+LAS+LLEWIRRTIPWLE+R P+KT+Q MQ
Sbjct: 258 GAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQ 317
Query: 330 QKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQH 389
+KLEDFRDYRR HKPPKVQEKCQLEINFNTLQTKLR+SNRPAFMPSEGKMVSDI WQ
Sbjct: 318 KKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQR 377
Query: 390 LEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI 449
LEQAEKGYEEWLLNEIRRLERL+HLAEKFRQKAS HE W GKE +L +DYE+A+L+++
Sbjct: 378 LEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEV 437
Query: 450 KALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLT 509
+AL+RKHEAFESDLAAHQDRVEQIAAIAQELNELDY+D+ NVN RCQKICDQWD LG+LT
Sbjct: 438 RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497
Query: 510 HSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISA 569
RREALE+ EK LE IDQLHLE+AKRAAPFNNWME AMEDLQDMFIVH+IEEI+ LI+A
Sbjct: 498 QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
H+QFK+TLP+AD ER++I+AI E +++ +S +I++S SNPY+TVT + +KW+KV+QL
Sbjct: 558 HEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQL 617
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSH 689
VP RD +L EE ++Q +NE LRRQFA+QAN +GPWIQ KMEEI R SI++ G LEDQ++
Sbjct: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQ 677
Query: 690 LKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 749
LKQYE +I++YK N+D LE HQLIQEAL+FDNKHTNYTMEHIRVGWE LLTTIARTINE
Sbjct: 678 LKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINE 737
Query: 750 VENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEA 809
VE QILTRDAKGI+QEQM EFRASFNHFD+ G + E+F+ACLIS+GYD+ GEA
Sbjct: 738 VETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDL-----GEA 792
Query: 810 EFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRR 869
EF RIM+LVDPN G VTFQ+FIDFM+RET DTDTA+QVIASF++LA DK +I AEELRR
Sbjct: 793 EFARIMTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRR 852
Query: 870 ELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911
ELPPDQA+YCI RM Y GP +VPGALDY +FS+ALYGESDL
Sbjct: 853 ELPPDQAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 1390 bits (3597), Expect = 0.0
Identities = 666/900 (74%), Positives = 790/900 (87%), Gaps = 8/900 (0%)
Query: 15 PSSAGNGAG---GGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQI 71
P G G G GGG G+YM QE+DWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQI
Sbjct: 7 PEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQI 66
Query: 72 ENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGA 131
ENI+EDFR+GLKLMLLLEVISGERLP+P++GKMR HKI NVNKALDFIASKGVKLVSIGA
Sbjct: 67 ENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGA 126
Query: 132 EEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHIS 191
EEIVDGN KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVNVQNFH S
Sbjct: 127 EEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTS 186
Query: 192 WKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTAR 251
WKDGLA ALIHRHRP+LI+Y KLRKDDP+ NLN AFEVAEKYLDIPKMLDAEDIVNT +
Sbjct: 187 WKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPK 246
Query: 252 PDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRR 311
PDEKAIMTYVS FYHAF+GA++AETAANRICKVLAVNQENE LME+YEKLAS+LLEWIRR
Sbjct: 247 PDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRR 306
Query: 312 TIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPA 371
T+PWLE+RV + ++ MQ+KLEDFRDYRR+HKPP++QEKCQLEINFNTLQTKLRLS+RPA
Sbjct: 307 TVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPA 366
Query: 372 FMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG 431
FMPSEGK+VSDI N W+ LEQ EKGYE+WLL+EIRRL+RL HLAEKFRQKAS+HEAWT G
Sbjct: 367 FMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRG 426
Query: 432 KEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNV 491
KE ML RDY++A L +++AL+R+HEAFESDLAAHQDRVE IAA+AQELNELDY+++ +V
Sbjct: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
Query: 492 NTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551
N+RCQ ICDQWD LG+LT RR+ALE+ EK LE IDQL LE+A+RAAPFNNW++ A+EDL
Sbjct: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDL 546
Query: 552 QDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY 611
QD+++VH++EE + L++AHDQFK+TLP+ADRER AI+ I E Q+I ++ ++ +NPY
Sbjct: 547 QDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
Query: 612 TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEE 671
T++PQ IN+KW+ V++LVP RD L EE ++QQ NE LRRQFA+QAN +GPWIQ K+EE
Sbjct: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
Query: 672 IGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEH 731
+GR++ + G+LE+Q++ L+Q E++I++YK N+D LE HQL+QE+L+FDNKHT Y+MEH
Sbjct: 667 VGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEH 726
Query: 732 IRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFK 791
IRVGWEQLLT+IARTINEVENQ+LTRDAKG+SQEQ+ EFRASFNHFD+ G + P++F+
Sbjct: 727 IRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFR 786
Query: 792 ACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIAS 851
ACLIS+GYD+ GE EF RIM++VDPN +G+VTFQAFIDFM+RET +TDT +QV+AS
Sbjct: 787 ACLISMGYDL-----GEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVAS 841
Query: 852 FKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911
FK+LAGDKN+IT EELRRELP QAEYCI RM PY+G A GALDY +FS+ALYGESDL
Sbjct: 842 FKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 449 bits (1156), Expect = e-126
Identities = 272/721 (37%), Positives = 412/721 (57%), Gaps = 63/721 (8%)
Query: 36 DDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIENIDEDFRDGLK 83
DDWD + +E+ Q+KTFT W NSHL + +I ++ D RDG
Sbjct: 28 DDWDNENSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRM 87
Query: 84 LMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTL 143
L+ LLEV+SGERLPKP +G+MR+H + NV+KAL F+ + V L ++G+ +IVDGN ++TL
Sbjct: 88 LIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTL 147
Query: 144 GMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLA 197
G+IWTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVN+ NF SW+DG+A
Sbjct: 148 GLIWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMA 207
Query: 198 FNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAI 257
FNALIH+HRP+LI++DKL+K + NL NAF +AE++L + K+LD EDI + PDEK+I
Sbjct: 208 FNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSI 266
Query: 258 MTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLE 317
+TYV ++YH FS + RI KVL E E ++E YE LASDLLEWI +TI L
Sbjct: 267 ITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILN 326
Query: 318 DRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEG 377
+R ++ +QQ+L+ F YR V KPPK EK LE+ T+Q+K+R +N+ +MP EG
Sbjct: 327 NRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREG 386
Query: 378 KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
K++SDIN W+ LE+AE E L NE+ R E+L+ LA +F +KA++ E W + ++
Sbjct: 387 KLISDINKAWERLEKAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS 446
Query: 438 HRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQK 497
+D L ++A +KHEA E+D+AA+++RV+ + A+A+EL +Y+D + R
Sbjct: 447 -QDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDN 505
Query: 498 ICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIV 557
+ W+ L L +RR+ LE L+ I Q L +WM+ +
Sbjct: 506 VIRLWEYLLELLRARRQRLE-MNLGLQKIFQEMLY-------IMDWMDEMKVLVLSQDYG 557
Query: 558 HTIEEIEGLISAHDQFKSTLPDAD--REREAILAIHKEAQRIAESNHIKLSGSNPYTTVT 615
+ +E L+ H TL +AD + E + ++ AQ+ A + Y
Sbjct: 558 KHLLGVEDLLQKH-----TLVEADIGIQAERVRGVNASAQKFA-------TDGEGYKPCD 605
Query: 616 PQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTK------- 668
PQ+I + ++ + E +++ + + L + F A G WI+ K
Sbjct: 606 PQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEG-WIREKEKILSSD 664
Query: 669 -----MEEIGRISIEMNGTLEDQLS-HLKQYERSIVDYKPNLDLLEQQH---QLIQEALI 719
+ + R+ + + ED++S +E++I K D++ ++H + I+E +I
Sbjct: 665 DYGKDLTSVMRL-LSKHRAFEDEMSGRSGHFEQAI---KEGEDMIAEEHFGSEKIRERII 720
Query: 720 F 720
+
Sbjct: 721 Y 721
Score = 66.6 bits (161), Expect = 1e-10
Identities = 82/378 (21%), Positives = 166/378 (43%), Gaps = 65/378 (17%)
Query: 383 INNGWQHLEQAEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDG-----KEAM 435
I W +LEQ L+ IR+ +RL+ L +F+ A +AW +
Sbjct: 722 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 771
Query: 436 LKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRC 495
+ H +Y T ++L++KH+ ++A ++ ++ + A L + ++ +S +V R
Sbjct: 772 VGHDEYST------QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRL 824
Query: 496 QKICDQWDALGSLTHSRREALEKT---EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQ 552
I +++ + LT R++AL+ T K D L W++ + L
Sbjct: 825 SGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACEL-----------WIDEKEQWLN 873
Query: 553 DMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYT 612
+M I +E++E + +F+S P+ + + + +++ A+++ S H S
Sbjct: 874 NMQIPEKLEDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGH----PSEKEI 926
Query: 613 TVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEI 672
+N++W + ++LV ++ ALL S Q N HL + N WI+ K +
Sbjct: 927 KAQQDKLNTRWSQFRELVDRKKDALLSALSIQ--NYHL------ECNETKSWIREKTK-- 976
Query: 673 GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQ-HQLIQEALIFDNKHTNYT--- 728
IE L + L+ + +R + + +L +E + L +EA +++H +
Sbjct: 977 ---VIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1033
Query: 729 ---MEHIRVGWEQLLTTI 743
+ I WE++ TT+
Sbjct: 1034 LSRLAEISDVWEEMKTTL 1051
Score = 60.8 bits (146), Expect = 5e-09
Identities = 67/277 (24%), Positives = 114/277 (41%), Gaps = 38/277 (13%)
Query: 407 RLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466
RLE L + F + A E W KE +L DY L+ + L+ KH AFE +++
Sbjct: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 690
Query: 467 QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAI 526
EQ +++ +++ S + R I +QW L L+ R+ K+LE
Sbjct: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK-------KRLEEA 743
Query: 527 DQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREA 586
LH ++ A + WM ++ + + H + L+ H K + R
Sbjct: 744 SLLH-QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799
Query: 587 ILAIHKEA----QRIAESNHI--KLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE 640
+ +H++A Q AES + +LSG I ++++V +L R AL
Sbjct: 800 LDTLHEQASALPQEHAESPDVRGRLSG-----------IEERYKEVAELTRLRKQAL--- 845
Query: 641 QSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI 677
Q L + F S+A+ WI K + + + I
Sbjct: 846 ----QDTLALYKMF-SEADACELWIDEKEQWLNNMQI 877
Score = 44.7 bits (104), Expect = 4e-04
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 26/193 (13%)
Query: 404 EIRRLERLDHLAEKFRQKASIHEA--WTDGK----EAMLKHRDYETATLSDIKALIRKHE 457
E RR+ +D +KFR + + + W + EA K RD +S ++ L+ H+
Sbjct: 1901 ESRRVRLVD-TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRD-----VSSVELLMNNHQ 1954
Query: 458 AFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE 517
++++ A D + + L +Y S + + L LT R+E ++
Sbjct: 1955 GIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEK----------LLQLTEKRKEMID 2004
Query: 518 KTEKQ---LEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFK 574
K E + L I ++H ++++ A+ W+ L I +++E+E LI H+ F+
Sbjct: 2005 KWEDRWEWLRLILEVH-QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFE 2063
Query: 575 STLPDADREREAI 587
+ D A+
Sbjct: 2064 KSAATWDERFSAL 2076
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 309 IRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSN 368
+R + W+ED + Q QE + + H+ K + + + ++ L
Sbjct: 1920 VRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLA 1979
Query: 369 RPAFMPSE--GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 426
R + E K++ + +++ E +E WL RL +F + AS+ E
Sbjct: 1980 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WL--------RLILEVHQFSRDASVAE 2030
Query: 427 AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR 469
AW G+E L R+ + + +++ LI++HEAFE A +R
Sbjct: 2031 AWLLGQEPYLSSREIGQS-VDEVEKLIKRHEAFEKSAATWDER 2072
Score = 39.7 bits (91), Expect = 0.013
Identities = 138/756 (18%), Positives = 279/756 (36%), Gaps = 148/756 (19%)
Query: 153 FAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAF-----NALIHRHRP 207
F Q + +T E +W R+ ++ Q F K AF L H P
Sbjct: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198
Query: 208 ELIEYDKL---RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSF 264
+E + +++D +T ++ E ++ + L ++ +N+ R EK V S
Sbjct: 1199 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEK-----VDSI 1253
Query: 265 YHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT 324
+K A+ + L N++ + ++D ++L+ W+ +++ T
Sbjct: 1254 DDRH---RKNRETASELLMRLKDNRDLQKFLQDCQELSL-----------WINEKM--LT 1297
Query: 325 IQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNT-------LQTKLRLSNRPAFMPSEG 377
Q+M + + R +H + E+ N + +S +P
Sbjct: 1298 AQDMS-----YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK 1352
Query: 378 KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+ ++ ++ W+ LE + + L + + AE F Q + + W G E+ ++
Sbjct: 1353 EKLTGLHKMWEVLESTTQTKAQRLFDANK--------AELFTQSCADLDKWLHGLESQIQ 1404
Query: 438 HRDYETATLSDIKALIRKHEAFESDLAAHQDRVE----QIAAIAQELNELDYYDSHNVNT 493
DY L+ + L++K + E+ + + +E Q A++QE D DS +
Sbjct: 1405 SDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV 1463
Query: 494 RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD 553
+ K + + L H+ + E + + D++ W+ M
Sbjct: 1464 Q-TKFMELLEPLNERKHNLLASKEIHQFNRDVEDEI------------LWVGERMPLATS 1510
Query: 554 MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
H ++ ++ LI + + + + I I + +Q I + ++
Sbjct: 1511 TDHGHNLQTVQLLIKKNQTLQK---EIQGHQPRIDDIFERSQNIVTDS----------SS 1557
Query: 614 VTPQIINSKWEKVQQLVPKRDHALLEEQSKQQ---SNEHLRRQFASQANVVGPWIQTKME 670
++ + I + ++QL L+EE K+ H +Q+ A W+ +
Sbjct: 1558 LSAEAIRQRLADLKQLW----GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--Q 1611
Query: 671 EIGRISIEMNGTLEDQLSHLKQY---ERSIVDYKPNLDLLEQQHQL--IQEALIFDN--K 723
E+ +S E + +S LK++ E+++ DY E HQL AL+ D+ +
Sbjct: 1612 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDY------AETVHQLSKTSRALVADSHPE 1665
Query: 724 HTNYTMEHIRV-----GWEQL-------------LTTIARTINEVENQILTRDAKGISQE 765
+M +V G + L L + R ++++E I R+ S E
Sbjct: 1666 SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHE 1725
Query: 766 QMQEF------RASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVD 819
Q++ + F F +D G +G E D N E L++
Sbjct: 1726 LGQDYEHVTMLQERFREFARDTGN-IGQER---------VDTVNHLADE--------LIN 1767
Query: 820 PNHSGLVTFQAFIDFMSRETTD----TDTADQVIAS 851
HS T + D ++ D DT Q++A+
Sbjct: 1768 SGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAA 1803
Score = 38.1 bits (87), Expect = 0.038
Identities = 63/322 (19%), Positives = 115/322 (35%), Gaps = 54/322 (16%)
Query: 408 LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD-------IKALIRKHEAFE 460
LE +D + +H+ + D KE + +D + ++ L R H FE
Sbjct: 1791 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFE 1850
Query: 461 SDLAAHQDRVEQIAAIAQELNELDYYD-SHNVNTRCQKICDQWDALGSLTHSRREALEKT 519
D+ A +V Q+ A L D + ++ R ++ + W +L SRR L T
Sbjct: 1851 HDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDT 1910
Query: 520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
+ + WME + ++ + +E L++ H K+ +
Sbjct: 1911 GDK--------FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDA 1962
Query: 580 ADREREAILAIHKE--AQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHAL 637
+ + + K A++ S IK EK+ QL KR +
Sbjct: 1963 RNDSFTTCIELGKSLLARKHYASEEIK-------------------EKLLQLTEKRKEMI 2003
Query: 638 LEEQSKQQSNEHLR-----RQFASQANVVGPWI-----QTKMEEIGRISIEMNGTLEDQL 687
+ + + E LR QF+ A+V W+ EIG+ E +E +
Sbjct: 2004 DKWEDRW---EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDE----VEKLI 2056
Query: 688 SHLKQYERSIVDYKPNLDLLEQ 709
+ +E+S + LE+
Sbjct: 2057 KRHEAFEKSAATWDERFSALER 2078
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 449 bits (1154), Expect = e-126
Identities = 268/696 (38%), Positives = 405/696 (58%), Gaps = 51/696 (7%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
E Q+KTFT W NSHL + +I ++ D RDG L+ LLEV+SGERLPKP +G+MR+H
Sbjct: 40 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 99
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVE------E 162
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 100 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 159
Query: 163 TSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVT 222
SAK+ LLLWCQ KTA Y NVN+ NF SW+DG+AFNALIH+HRP+LI++DKL+K +
Sbjct: 160 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 219
Query: 223 NLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 282
NL NAF +AE++L + K+LD EDI + PDEK+I+TYV ++YH FS + RI
Sbjct: 220 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 278
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
KVL E E ++E YE LASDLLEWI +TI L +R ++ +QQ+L+ F YR V
Sbjct: 279 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 338
Query: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
KPPK EK LE+ T+Q+K+R +N+ +MP EGK++SDIN W+ LE+AE E L
Sbjct: 339 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 398
Query: 403 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
NE+ R E+L+ LA +F +KA++ E W + ++ +D L ++A +KHEA E+D
Sbjct: 399 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVS-QDNFGFDLPAVEAATKKHEAIETD 457
Query: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQ 522
+AA+++RV+ + A+A+EL +Y+D + R + W+ L L +RR+ LE
Sbjct: 458 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE-MNLG 516
Query: 523 LEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD- 581
L+ I Q L +WM+ + + +E L+ H TL +AD
Sbjct: 517 LQKIFQEMLY-------IMDWMDEMKVLVLSQDYGKHLLGVEDLLQKH-----TLVEADI 564
Query: 582 -REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE 640
+ E + ++ AQ+ A + Y PQ+I + ++ + E
Sbjct: 565 GIQAERVRGVNASAQKFA-------TDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAER 617
Query: 641 QSKQQSNEHLRRQFASQANVVGPWIQTK------------MEEIGRISIEMNGTLEDQLS 688
+++ + + L + F A G WI+ K + + R+ + + ED++S
Sbjct: 618 RARLEESRRLWKFFWEMAEEEG-WIREKEKILSSDDYGKDLTSVMRL-LSKHRAFEDEMS 675
Query: 689 -HLKQYERSIVDYKPNLDLLEQQH---QLIQEALIF 720
+E++I K D++ ++H + I+E +I+
Sbjct: 676 GRSGHFEQAI---KEGEDMIAEEHFGSEKIRERIIY 708
Score = 66.6 bits (161), Expect = 1e-10
Identities = 82/378 (21%), Positives = 166/378 (43%), Gaps = 65/378 (17%)
Query: 383 INNGWQHLEQAEKGYEEWLLNEIRRLERLDH--LAEKFRQKASIHEAWTDG-----KEAM 435
I W +LEQ L+ IR+ +RL+ L +F+ A +AW +
Sbjct: 709 IREQWANLEQ---------LSAIRK-KRLEEASLLHQFQADADDIDAWMLDILKIVSSSD 758
Query: 436 LKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRC 495
+ H +Y T ++L++KH+ ++A ++ ++ + A L + ++ +S +V R
Sbjct: 759 VGHDEYST------QSLVKKHKDVAEEIANYRPTLDTLHEQASALPQ-EHAESPDVRGRL 811
Query: 496 QKICDQWDALGSLTHSRREALEKT---EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQ 552
I +++ + LT R++AL+ T K D L W++ + L
Sbjct: 812 SGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACEL-----------WIDEKEQWLN 860
Query: 553 DMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYT 612
+M I +E++E + +F+S P+ + + + +++ A+++ S H S
Sbjct: 861 NMQIPEKLEDLEVI---QHRFESLEPEMNNQASRVAVVNQIARQLMHSGH----PSEKEI 913
Query: 613 TVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEI 672
+N++W + ++LV ++ ALL S Q N HL + N WI+ K +
Sbjct: 914 KAQQDKLNTRWSQFRELVDRKKDALLSALSIQ--NYHL------ECNETKSWIREKTK-- 963
Query: 673 GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQ-HQLIQEALIFDNKHTNYT--- 728
IE L + L+ + +R + + +L +E + L +EA +++H +
Sbjct: 964 ---VIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAI 1020
Query: 729 ---MEHIRVGWEQLLTTI 743
+ I WE++ TT+
Sbjct: 1021 LSRLAEISDVWEEMKTTL 1038
Score = 60.8 bits (146), Expect = 5e-09
Identities = 67/277 (24%), Positives = 114/277 (41%), Gaps = 38/277 (13%)
Query: 407 RLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466
RLE L + F + A E W KE +L DY L+ + L+ KH AFE +++
Sbjct: 620 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGK-DLTSVMRLLSKHRAFEDEMSGR 677
Query: 467 QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAI 526
EQ +++ +++ S + R I +QW L L+ R+ K+LE
Sbjct: 678 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRK-------KRLEEA 730
Query: 527 DQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREA 586
LH ++ A + WM ++ + + H + L+ H K + R
Sbjct: 731 SLLH-QFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 786
Query: 587 ILAIHKEA----QRIAESNHI--KLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE 640
+ +H++A Q AES + +LSG I ++++V +L R AL
Sbjct: 787 LDTLHEQASALPQEHAESPDVRGRLSG-----------IEERYKEVAELTRLRKQAL--- 832
Query: 641 QSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI 677
Q L + F S+A+ WI K + + + I
Sbjct: 833 ----QDTLALYKMF-SEADACELWIDEKEQWLNNMQI 864
Score = 44.7 bits (104), Expect = 4e-04
Identities = 43/193 (22%), Positives = 84/193 (43%), Gaps = 26/193 (13%)
Query: 404 EIRRLERLDHLAEKFRQKASIHEA--WTDGK----EAMLKHRDYETATLSDIKALIRKHE 457
E RR+ +D +KFR + + + W + EA K RD +S ++ L+ H+
Sbjct: 1888 ESRRVRLVD-TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRD-----VSSVELLMNNHQ 1941
Query: 458 AFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE 517
++++ A D + + L +Y S + + L LT R+E ++
Sbjct: 1942 GIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEK----------LLQLTEKRKEMID 1991
Query: 518 KTEKQ---LEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFK 574
K E + L I ++H ++++ A+ W+ L I +++E+E LI H+ F+
Sbjct: 1992 KWEDRWEWLRLILEVH-QFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFE 2050
Query: 575 STLPDADREREAI 587
+ D A+
Sbjct: 2051 KSAATWDERFSAL 2063
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 12/163 (7%)
Query: 309 IRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSN 368
+R + W+ED + Q QE + + H+ K + + + ++ L
Sbjct: 1907 VRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLA 1966
Query: 369 RPAFMPSE--GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE 426
R + E K++ + +++ E +E WL RL +F + AS+ E
Sbjct: 1967 RKHYASEEIKEKLLQLTEKRKEMIDKWEDRWE-WL--------RLILEVHQFSRDASVAE 2017
Query: 427 AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR 469
AW G+E L R+ + + +++ LI++HEAFE A +R
Sbjct: 2018 AWLLGQEPYLSSREIGQS-VDEVEKLIKRHEAFEKSAATWDER 2059
Score = 39.7 bits (91), Expect = 0.013
Identities = 138/756 (18%), Positives = 279/756 (36%), Gaps = 148/756 (19%)
Query: 153 FAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAF-----NALIHRHRP 207
F Q + +T E +W R+ ++ Q F K AF L H P
Sbjct: 1126 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1185
Query: 208 ELIEYDKL---RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSF 264
+E + +++D +T ++ E ++ + L ++ +N+ R EK V S
Sbjct: 1186 TTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEK-----VDSI 1240
Query: 265 YHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT 324
+K A+ + L N++ + ++D ++L+ W+ +++ T
Sbjct: 1241 DDRH---RKNRETASELLMRLKDNRDLQKFLQDCQELSL-----------WINEKM--LT 1284
Query: 325 IQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNT-------LQTKLRLSNRPAFMPSEG 377
Q+M + + R +H + E+ N + +S +P
Sbjct: 1285 AQDMS-----YDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVK 1339
Query: 378 KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+ ++ ++ W+ LE + + L + + AE F Q + + W G E+ ++
Sbjct: 1340 EKLTGLHKMWEVLESTTQTKAQRLFDANK--------AELFTQSCADLDKWLHGLESQIQ 1391
Query: 438 HRDYETATLSDIKALIRKHEAFESDLAAHQDRVE----QIAAIAQELNELDYYDSHNVNT 493
DY L+ + L++K + E+ + + +E Q A++QE D DS +
Sbjct: 1392 SDDY-GKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTV 1450
Query: 494 RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD 553
+ K + + L H+ + E + + D++ W+ M
Sbjct: 1451 Q-TKFMELLEPLNERKHNLLASKEIHQFNRDVEDEI------------LWVGERMPLATS 1497
Query: 554 MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
H ++ ++ LI + + + + I I + +Q I + ++
Sbjct: 1498 TDHGHNLQTVQLLIKKNQTLQK---EIQGHQPRIDDIFERSQNIVTDS----------SS 1544
Query: 614 VTPQIINSKWEKVQQLVPKRDHALLEEQSKQQ---SNEHLRRQFASQANVVGPWIQTKME 670
++ + I + ++QL L+EE K+ H +Q+ A W+ +
Sbjct: 1545 LSAEAIRQRLADLKQLW----GLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSE--Q 1598
Query: 671 EIGRISIEMNGTLEDQLSHLKQY---ERSIVDYKPNLDLLEQQHQL--IQEALIFDN--K 723
E+ +S E + +S LK++ E+++ DY E HQL AL+ D+ +
Sbjct: 1599 ELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDY------AETVHQLSKTSRALVADSHPE 1652
Query: 724 HTNYTMEHIRV-----GWEQL-------------LTTIARTINEVENQILTRDAKGISQE 765
+M +V G + L L + R ++++E I R+ S E
Sbjct: 1653 SERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHE 1712
Query: 766 QMQEF------RASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLVD 819
Q++ + F F +D G +G E D N E L++
Sbjct: 1713 LGQDYEHVTMLQERFREFARDTGN-IGQER---------VDTVNHLADE--------LIN 1754
Query: 820 PNHSGLVTFQAFIDFMSRETTD----TDTADQVIAS 851
HS T + D ++ D DT Q++A+
Sbjct: 1755 SGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAA 1790
Score = 38.1 bits (87), Expect = 0.038
Identities = 63/322 (19%), Positives = 115/322 (35%), Gaps = 54/322 (16%)
Query: 408 LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD-------IKALIRKHEAFE 460
LE +D + +H+ + D KE + +D + ++ L R H FE
Sbjct: 1778 LELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFE 1837
Query: 461 SDLAAHQDRVEQIAAIAQELNELDYYD-SHNVNTRCQKICDQWDALGSLTHSRREALEKT 519
D+ A +V Q+ A L D + ++ R ++ + W +L SRR L T
Sbjct: 1838 HDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDT 1897
Query: 520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
+ + WME + ++ + +E L++ H K+ +
Sbjct: 1898 GDK--------FRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDA 1949
Query: 580 ADREREAILAIHKE--AQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHAL 637
+ + + K A++ S IK EK+ QL KR +
Sbjct: 1950 RNDSFTTCIELGKSLLARKHYASEEIK-------------------EKLLQLTEKRKEMI 1990
Query: 638 LEEQSKQQSNEHLR-----RQFASQANVVGPWI-----QTKMEEIGRISIEMNGTLEDQL 687
+ + + E LR QF+ A+V W+ EIG+ E +E +
Sbjct: 1991 DKWEDRW---EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDE----VEKLI 2043
Query: 688 SHLKQYERSIVDYKPNLDLLEQ 709
+ +E+S + LE+
Sbjct: 2044 KRHEAFEKSAATWDERFSALER 2065
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 444 bits (1141), Expect = e-124
Identities = 261/704 (37%), Positives = 389/704 (55%), Gaps = 45/704 (6%)
Query: 35 EDDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIENIDEDFRDGL 82
+ DWD D +E+ Q+KTFT W NSHL + ++ ++ D RDG
Sbjct: 30 DSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGR 89
Query: 83 KLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMT 142
L+ LLEV+SGE LPKP +G+MR+H + NV+KAL F+ + V L ++G+ +IVDGN ++T
Sbjct: 90 NLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLT 149
Query: 143 LGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGL 196
LG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVNV NF SW+DGL
Sbjct: 150 LGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGL 209
Query: 197 AFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKA 256
AFNA++H+HRP+L++++ L+K + NL NAF +AEK L + K+LD ED VN +PDEK+
Sbjct: 210 AFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED-VNVDQPDEKS 268
Query: 257 IMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWL 316
I+TYV+++YH FS + RI KVL E E L+E YE LAS+LL+WI +TI L
Sbjct: 269 IITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTL 328
Query: 317 EDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSE 376
DR ++ +Q +L+ F YR V KPPK EK LE+ T+Q+KLR +N+ + P E
Sbjct: 329 NDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPRE 388
Query: 377 GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAML 436
G+++SDIN W+ LE+AE E L E+ R E+L+ LA +F +KA++ E W + ++
Sbjct: 389 GRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV 448
Query: 437 KHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQ 496
+D L+ ++A +RKHEA E+D+ A+ RV+ + A+A EL Y+D + R
Sbjct: 449 S-QDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
Query: 497 KICDQWDALGSLTHSRRE-ALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMF 555
+ WD L + +RRE L E Q D L+L +WME LQ
Sbjct: 508 NVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYL---------MDWMEEMKGRLQSQD 558
Query: 556 IVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKL-SGSNPYTTV 614
+ + +E L+ H+ EA +A+ E R ++ ++ + Y
Sbjct: 559 LGRHLAGVEDLLQLHELV-----------EADIAVQAERVRAVSASALRFCNPGKEYRPC 607
Query: 615 TPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGR 674
PQ+++ + K++Q +++ + + L R F + W++ + +
Sbjct: 608 DPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWR-FLWEVGEAEAWVREQQHLLAS 666
Query: 675 ISI--EMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE 716
++ G L H P LEQ QL+ E
Sbjct: 667 ADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAE 710
Score = 57.0 bits (136), Expect = 8e-08
Identities = 97/468 (20%), Positives = 185/468 (39%), Gaps = 66/468 (14%)
Query: 282 CKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRV 341
C+ L ++E D E I W+ +R+P M +E +D V
Sbjct: 1481 CRRLQASREQHQFHRDVED-----------EILWVTERLP------MASSMEHGKDLPSV 1523
Query: 342 HKPPKVQEKCQLEINFNTLQ-TKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEW 400
K + Q EI + + LR R + G ++++ W+ L G+E
Sbjct: 1524 QLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRL-----GHELE 1578
Query: 401 LLNEIRRLERLDHL-AEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAF 459
L +RLE D L A++F + A+ EAW +E + ++ LS +A ++KH+
Sbjct: 1579 LRG--KRLE--DALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELS-AQAEVKKHQVL 1633
Query: 460 ESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT 519
E LA + + Q+AA +Q++ + ++ +S ++ R ++ + L L RRE L++
Sbjct: 1634 EQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQE- 1692
Query: 520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTI-EEIEGLISAHDQFKSTLP 578
HL + ++ +E +++ + + H + ++ E + D+F+
Sbjct: 1693 ----------HLRLCQLRRELDD-LEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSR 1741
Query: 579 DADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVT--PQIINSKWEKVQQLVPKRDHA 636
D + + + A +N + G TV +N W + +L+ R
Sbjct: 1742 DT-----STIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQV 1796
Query: 637 LLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEI----GRISIEMNGTLEDQLSHLKQ 692
L Q+ R+ A +Q K +++ GR ++N Q H
Sbjct: 1797 LAAAYELQRFLHGARQALAR--------VQHKQQQLPDGTGR---DLNAAEALQRRHC-A 1844
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDN-KHTNYTMEHIRVGWEQL 739
YE I P + ++ +Q+A D + M+ + W QL
Sbjct: 1845 YEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQL 1892
Score = 47.4 bits (111), Expect = 6e-05
Identities = 79/435 (18%), Positives = 162/435 (37%), Gaps = 52/435 (11%)
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
+++A +E L + +K+ DLL + W+E+ + Q++ + L D ++H
Sbjct: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
Query: 343 KPPKVQEKCQLEINFNTLQTKLRLSNR-PAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
+ + Q E + LR N + P + ++VS+ + + E+ YE
Sbjct: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSE------RVAKLEQSYEALC 627
Query: 402 LNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAF 459
R RL+ +F + EAW ++ +L D L+ L+ KH A
Sbjct: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASAD-TGRDLTGALRLLNKHTAL 686
Query: 460 ESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT 519
+++ ++ Q+L + + + R ++ QW+ L +L R + L +
Sbjct: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
Query: 520 EKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAH----DQFKS 575
++ A W+ A+ + + H + L H ++ +S
Sbjct: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
Query: 576 TLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
P D RE A+ R E + G P + +E++Q +R
Sbjct: 799 HRPTLDALREQAAALPPTLSRTPE-----VQGRVP-------TLERHYEELQARAGERAR 846
Query: 636 ALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYER 695
AL + S+A G W++ K + + ++ L ++L L+ ++
Sbjct: 847 ALEAALALY--------TMLSEAGACGLWVEEKEQWLNGLA------LPERLEDLEVVQQ 892
Query: 696 SIVDYKPNLDLLEQQ 710
+P ++ L Q
Sbjct: 893 RFETLEPEMNTLAAQ 907
Score = 44.3 bits (103), Expect = 5e-04
Identities = 69/354 (19%), Positives = 137/354 (38%), Gaps = 35/354 (9%)
Query: 359 TLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKF 418
T + + PA + + ++ GW+ L + EE L E RRL+ F
Sbjct: 1019 TREANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREE-SLGEARRLQ-------DF 1070
Query: 419 RQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478
+ +AW G+ + ATL + +AL+ +H A ++ Q ++ A+ +
Sbjct: 1071 LRSLDDFQAWL-GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGE 1129
Query: 479 ELNELDYYDSH--NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKR 536
E+ D D + R + + W+ LG + SR+ L + Q L A++
Sbjct: 1130 EVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHG-----FQGFLRDARQ 1183
Query: 537 AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQR 596
A + E + + + T++ + I + F ST+ DA+ ER L + Q
Sbjct: 1184 AEGVLSSQEYVLSHTE---MPGTLQAADAAIKKLEDFMSTM-DANGERIHGL-LEAGRQL 1238
Query: 597 IAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFAS 656
++E N + I K + +++ K A + + + N ++ F
Sbjct: 1239 VSEGN------------IHADKIREKADSIERRHKKNQDAAQQFLGRLRDNRE-QQHFLQ 1285
Query: 657 QANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQ 710
+ + WI KM +S + L + + + + K LD ++++
Sbjct: 1286 DCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKE 1339
Score = 43.5 bits (101), Expect = 9e-04
Identities = 41/198 (20%), Positives = 88/198 (44%), Gaps = 25/198 (12%)
Query: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA--WTDG----KEAMLKHRDY 441
+H++ + + + + R + L +KFR ++ E W D +A + RD
Sbjct: 1880 RHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDV 1939
Query: 442 ETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ 501
+A L +I+ + ++++ A DR + +EL +Y + ++ +
Sbjct: 1940 SSADL-----VIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEK------- 1987
Query: 502 WDALGSLTHSRREALEKTEKQLEAIDQLHLE---YAKRAAPFNNWMESAMEDLQDMFIVH 558
L L R+E EK +++++ + QL LE + + A W+ S ++ +
Sbjct: 1988 ---LSQLQARRQETAEKWQEKMDWL-QLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGC 2043
Query: 559 TIEEIEGLISAHDQFKST 576
T++E+E LI H+ F+ +
Sbjct: 2044 TVDEVESLIKRHEAFQKS 2061
Score = 42.4 bits (98), Expect = 0.002
Identities = 57/277 (20%), Positives = 116/277 (41%), Gaps = 24/277 (8%)
Query: 375 SEGKMVSD-INNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 433
SEG + +D I +E+ K ++ + RL R + + F Q + W D E
Sbjct: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRL-RDNREQQHFLQDCHELKLWID--E 1296
Query: 434 AMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNT 493
ML +D ++ +KH+AF ++LAA++D ++++ +EL V+
Sbjct: 1297 KMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSE 1356
Query: 494 RCQKICDQWDALGSLTHSR-REALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQ 552
+ + + +WD L + T ++ R + +L +A+ +W+ES L
Sbjct: 1357 KLRDLHRRWDELETTTQAKARSLFDANRAEL---------FAQSCCALESWLESLQAQLH 1407
Query: 553 DMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYT 612
+ + L+ + + ++E EAI A +A+ +A+ + G+
Sbjct: 1408 SDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQA---QAKALAQED----QGAGEVE 1460
Query: 613 TVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649
T + + K+ + Q P R+ + S++Q H
Sbjct: 1461 R-TSRAVEEKFRALCQ--PMRERCRRLQASREQHQFH 1494
Score = 36.2 bits (82), Expect = 0.14
Identities = 18/68 (26%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Query: 418 FRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR---VEQIA 474
F + A + EAW +E +++ + T+ ++++LI++HEAF+ A ++R +E++
Sbjct: 2018 FGRDAGMAEAWLCSQEPLVRSAELG-CTVDEVESLIKRHEAFQKSAVAWEERFCALEKLT 2076
Query: 475 AIAQELNE 482
A+ + E
Sbjct: 2077 ALEEREKE 2084
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 439 bits (1129), Expect = e-123
Identities = 265/716 (37%), Positives = 397/716 (55%), Gaps = 36/716 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE LPKP +GKMR+H
Sbjct: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV------EE 162
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
Query: 163 TSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVT 222
SAK+ LLLWCQ KTA Y +VNV NF SWKDGLAFNALIH+HRP+LI++DKL+ +
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
Query: 223 NLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 282
NL +AF VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
KV+ E E ++E Y LASDLL WI +TI L R ++ +QQ+L+ F YR V
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
Query: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
KPPK QEK LE+ T+Q+++R +N+ + P +GK+VSDIN W+ LE+AE E L
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
Query: 403 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
NE+ R E+L+ LA +F +KA++ E W + ++ +D L+ ++A +KHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVA-QDNFGYDLAAVEAAKKKHEAIETD 470
Query: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT-EK 521
AA+++RV + +AQEL + +Y+D + R I W L L SRR+ LE T
Sbjct: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
Query: 522 QLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD 581
Q D LH +WM+ L + E+E L+ H
Sbjct: 531 QKLFQDMLH---------SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH----------- 570
Query: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
+ EA +AI + + + +K + Y PQ+I + ++Q + + +
Sbjct: 571 KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
Query: 642 SKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI--EMNGTLEDQLSHLKQYERSIVD 699
++ + ++ L + F + + WI+ K + + ++ L Q H K +E +
Sbjct: 631 AQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRG 688
Query: 700 YKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 752
+L+ + Q+ + F + ++ + W+QL A + + + EN
Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
Score = 48.1 bits (113), Expect = 4e-05
Identities = 71/334 (21%), Positives = 137/334 (41%), Gaps = 45/334 (13%)
Query: 417 KFRQKASIHEAWTDGKEAMLKHRDY---ETATLSDIKALIRKHEAFESDLAAHQDRVEQI 473
+F+ A +AW +L D E AT +AL +KH+ F +L + +E +
Sbjct: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
Query: 474 AAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEY 533
AQ E ++ DS +V R Q + + + + + R++ L+ EA+D L+ +
Sbjct: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
Query: 534 AKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILA---- 589
+ A WM + L +M + T+E++E + D D+E + ++
Sbjct: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDIL-------DQEMKTLMTQIDG 906
Query: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649
++ A + ES H + Y +N++W+ Q LV +R A+ +
Sbjct: 907 VNLAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV---------DSA 953
Query: 650 LR-RQFASQANVVGPWIQTK---MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLD 705
LR + WI K +E + ++ G + Q L ER + + +D
Sbjct: 954 LRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVD 1012
Query: 706 LLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQL 739
LE++ Q + ++ + +H+ W+ L
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
Score = 44.3 bits (103), Expect = 5e-04
Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 38/270 (14%)
Query: 267 AFSGAQKAETAANRICKVLAVNQ--------ENEHLMEDYEK-----LASDLLEWIRRTI 313
A++G +KAE N+ +V A Q L++ +K +A DLL W+ I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
Query: 314 PWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 373
+E + E RD V K + EI + L + +
Sbjct: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
Query: 374 PSEGKMVSDINNGWQHLEQAEKGY-EEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTD 430
+ + +I Q + K E+W R ERL L E +F + AS+ EAW
Sbjct: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAEAWLI 2026
Query: 431 GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSH 489
+E L D+ T+ ++ LI++HEAFE A+ +R + EL E +
Sbjct: 2027 AQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
Query: 490 NVNTRCQKICDQWDALGSLTHSRREALEKT 519
T Q+ ++ + G S A E+T
Sbjct: 2086 AEETGPQE--EEGETAGEAPVSHHAATERT 2113
Score = 42.7 bits (99), Expect = 0.002
Identities = 84/422 (19%), Positives = 159/422 (37%), Gaps = 48/422 (11%)
Query: 375 SEGKMVSD-INNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 433
+EG + SD I Q +E + E E L R + + F Q W + K
Sbjct: 1236 AEGNLYSDKIKEKVQLIEDRHRKNNE-KAQEASVLLRDNLELQNFLQNCQELTLWINDKL 1294
Query: 434 AMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNT 493
+ Y+ A K L KH+AF ++LA+H+ +E I A ++L + + V+
Sbjct: 1295 LTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQ 1352
Query: 494 RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD 553
+ + + WD L + T + + L L L+ A N W+ SAMED
Sbjct: 1353 KLEALHRLWDELQATTKEKTQHLSAARSS-----DLRLQ---THADLNKWI-SAMED--- 1400
Query: 554 MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
Q +S D ++ ++ + + +R+ + +++
Sbjct: 1401 ------------------QLRSD--DPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 614 VTPQIINSKWEKVQQLVPKRDHALLE---EQSKQQSNEHLRRQFASQANVVGPWIQTKME 670
P + + + KR LLE + KQ + + Q + W++ ++
Sbjct: 1441 QVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLP 1499
Query: 671 EIGRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTM 729
N T++ + + + I+ + P ++ + Q+ Q + EA D + +
Sbjct: 1500 LAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERL 1559
Query: 730 EHIRVGWEQLLTTIA------RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGG 783
H++ W++L A R NE + L D + + QE + KD G
Sbjct: 1560 GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDAD-EAEAWIGEQELYVISDEIPKDEEG 1618
Query: 784 AL 785
A+
Sbjct: 1619 AI 1620
Score = 42.0 bits (97), Expect = 0.003
Identities = 55/305 (18%), Positives = 124/305 (40%), Gaps = 38/305 (12%)
Query: 428 WTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 487
W K +++ L+ I A+ RK E D+AA Q RV+ + +Q+L +
Sbjct: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
Query: 488 SHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESA 547
++ R + + + W L +++L+ E L + QL + + F W+
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
Query: 548 MEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA-QRIAESNHIKLS 606
+ + + ++ E E L+ H K + H+++ QR+ ES +
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDG-----------HQDSYQRVKESGEKVIQ 1129
Query: 607 GSN--PYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVG 662
G Y + ++ +++ W + ++ R H L + Q+ + ++ A +N
Sbjct: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN--- 1186
Query: 663 PWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDL----LEQQHQLIQEAL 718
+E +E +LE + ++++E + + N D ++ ++L+ E
Sbjct: 1187 -------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGN 1239
Query: 719 IFDNK 723
++ +K
Sbjct: 1240 LYSDK 1244
Score = 40.0 bits (92), Expect = 0.010
Identities = 41/206 (19%), Positives = 88/206 (42%), Gaps = 26/206 (12%)
Query: 382 DINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLKHR 439
+++ WQ L A G RR + +D A+KFR + + +W + ++ +
Sbjct: 1880 EVSAAWQALLDACAG---------RRTQLVD-TADKFRFFSMARDLLSWMESIIRQIETQ 1929
Query: 440 DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499
+ +S ++ L++ H+ +++ + + L + + S + + Q++
Sbjct: 1930 E-RPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988
Query: 500 DQWDALGSLTHSRREALEKTEKQLEAIDQLH--LEYAKRAAPFNNWMESAMEDLQDMFIV 557
+ R+E EK E + E + L ++++ A+ W+ + L
Sbjct: 1989 SR----------RKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
Query: 558 HTIEEIEGLISAHDQF-KSTLPDADR 582
HT++ +E LI H+ F KST A+R
Sbjct: 2039 HTVDSVEKLIKRHEAFEKSTASWAER 2064
Score = 37.4 bits (85), Expect = 0.064
Identities = 43/240 (17%), Positives = 90/240 (37%), Gaps = 40/240 (16%)
Query: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ-----------------------KASI 424
+HLEQ +G+ E + RL L E ++Q +
Sbjct: 800 EHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDA 859
Query: 425 HEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELD 484
E W KE L + TL D++ + + + + ++ +++ + A L E
Sbjct: 860 CELWMGEKEKWLAEMEMPD-TLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG 918
Query: 485 YYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWM 544
+ S V + +W A +L RREA++ + +H Y + W+
Sbjct: 919 HPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALR-------VH-NYCVDCEETSKWI 970
Query: 545 ---ESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESN 601
+E +D+ ++ G+I+ + D + + A+ +E+Q++ +S+
Sbjct: 971 TDKTKVVESTKDLG-----RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSH 1025
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 439 bits (1129), Expect = e-123
Identities = 265/716 (37%), Positives = 397/716 (55%), Gaps = 36/716 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE LPKP +GKMR+H
Sbjct: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV------EE 162
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
Query: 163 TSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVT 222
SAK+ LLLWCQ KTA Y +VNV NF SWKDGLAFNALIH+HRP+LI++DKL+ +
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
Query: 223 NLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 282
NL +AF VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
KV+ E E ++E Y LASDLL WI +TI L R ++ +QQ+L+ F YR V
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
Query: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
KPPK QEK LE+ T+Q+++R +N+ + P +GK+VSDIN W+ LE+AE E L
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
Query: 403 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
NE+ R E+L+ LA +F +KA++ E W + ++ +D L+ ++A +KHEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVA-QDNFGYDLAAVEAAKKKHEAIETD 470
Query: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT-EK 521
AA+++RV + +AQEL + +Y+D + R I W L L SRR+ LE T
Sbjct: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
Query: 522 QLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD 581
Q D LH +WM+ L + E+E L+ H
Sbjct: 531 QKLFQDMLH---------SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH----------- 570
Query: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
+ EA +AI + + + +K + Y PQ+I + ++Q + + +
Sbjct: 571 KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
Query: 642 SKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI--EMNGTLEDQLSHLKQYERSIVD 699
++ + ++ L + F + + WI+ K + + ++ L Q H K +E +
Sbjct: 631 AQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRG 688
Query: 700 YKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 752
+L+ + Q+ + F + ++ + W+QL A + + + EN
Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
Score = 48.1 bits (113), Expect = 4e-05
Identities = 71/334 (21%), Positives = 137/334 (41%), Gaps = 45/334 (13%)
Query: 417 KFRQKASIHEAWTDGKEAMLKHRDY---ETATLSDIKALIRKHEAFESDLAAHQDRVEQI 473
+F+ A +AW +L D E AT +AL +KH+ F +L + +E +
Sbjct: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
Query: 474 AAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEY 533
AQ E ++ DS +V R Q + + + + + R++ L+ EA+D L+ +
Sbjct: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
Query: 534 AKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILA---- 589
+ A WM + L +M + T+E++E + D D+E + ++
Sbjct: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDIL-------DQEMKTLMTQIDG 906
Query: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649
++ A + ES H + Y +N++W+ Q LV +R A+ +
Sbjct: 907 VNLAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV---------DSA 953
Query: 650 LR-RQFASQANVVGPWIQTK---MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLD 705
LR + WI K +E + ++ G + Q L ER + + +D
Sbjct: 954 LRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVD 1012
Query: 706 LLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQL 739
LE++ Q + ++ + +H+ W+ L
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
Score = 44.3 bits (103), Expect = 5e-04
Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 38/270 (14%)
Query: 267 AFSGAQKAETAANRICKVLAVNQ--------ENEHLMEDYEK-----LASDLLEWIRRTI 313
A++G +KAE N+ +V A Q L++ +K +A DLL W+ I
Sbjct: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
Query: 314 PWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 373
+E + E RD V K + EI + L + +
Sbjct: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
Query: 374 PSEGKMVSDINNGWQHLEQAEKGY-EEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTD 430
+ + +I Q + K E+W R ERL L E +F + AS+ EAW
Sbjct: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAEAWLI 2026
Query: 431 GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSH 489
+E L D+ T+ ++ LI++HEAFE A+ +R + EL E +
Sbjct: 2027 AQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
Query: 490 NVNTRCQKICDQWDALGSLTHSRREALEKT 519
T Q+ ++ + G S A E+T
Sbjct: 2086 AEETGPQE--EEGETAGEAPVSHHAATERT 2113
Score = 42.7 bits (99), Expect = 0.002
Identities = 84/422 (19%), Positives = 159/422 (37%), Gaps = 48/422 (11%)
Query: 375 SEGKMVSD-INNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 433
+EG + SD I Q +E + E E L R + + F Q W + K
Sbjct: 1236 AEGNLYSDKIKEKVQLIEDRHRKNNE-KAQEASVLLRDNLELQNFLQNCQELTLWINDKL 1294
Query: 434 AMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNT 493
+ Y+ A K L KH+AF ++LA+H+ +E I A ++L + + V+
Sbjct: 1295 LTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQ 1352
Query: 494 RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD 553
+ + + WD L + T + + L L L+ A N W+ SAMED
Sbjct: 1353 KLEALHRLWDELQATTKEKTQHLSAARSS-----DLRLQ---THADLNKWI-SAMED--- 1400
Query: 554 MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
Q +S D ++ ++ + + +R+ + +++
Sbjct: 1401 ------------------QLRSD--DPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 614 VTPQIINSKWEKVQQLVPKRDHALLE---EQSKQQSNEHLRRQFASQANVVGPWIQTKME 670
P + + + KR LLE + KQ + + Q + W++ ++
Sbjct: 1441 QVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLP 1499
Query: 671 EIGRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTM 729
N T++ + + + I+ + P ++ + Q+ Q + EA D + +
Sbjct: 1500 LAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERL 1559
Query: 730 EHIRVGWEQLLTTIA------RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGG 783
H++ W++L A R NE + L D + + QE + KD G
Sbjct: 1560 GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDAD-EAEAWIGEQELYVISDEIPKDEEG 1618
Query: 784 AL 785
A+
Sbjct: 1619 AI 1620
Score = 42.0 bits (97), Expect = 0.003
Identities = 55/305 (18%), Positives = 124/305 (40%), Gaps = 38/305 (12%)
Query: 428 WTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 487
W K +++ L+ I A+ RK E D+AA Q RV+ + +Q+L +
Sbjct: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
Query: 488 SHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESA 547
++ R + + + W L +++L+ E L + QL + + F W+
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
Query: 548 MEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA-QRIAESNHIKLS 606
+ + + ++ E E L+ H K + H+++ QR+ ES +
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDG-----------HQDSYQRVKESGEKVIQ 1129
Query: 607 GSN--PYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVG 662
G Y + ++ +++ W + ++ R H L + Q+ + ++ A +N
Sbjct: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN--- 1186
Query: 663 PWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDL----LEQQHQLIQEAL 718
+E +E +LE + ++++E + + N D ++ ++L+ E
Sbjct: 1187 -------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGN 1239
Query: 719 IFDNK 723
++ +K
Sbjct: 1240 LYSDK 1244
Score = 40.0 bits (92), Expect = 0.010
Identities = 41/206 (19%), Positives = 88/206 (42%), Gaps = 26/206 (12%)
Query: 382 DINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLKHR 439
+++ WQ L A G RR + +D A+KFR + + +W + ++ +
Sbjct: 1880 EVSAAWQALLDACAG---------RRTQLVD-TADKFRFFSMARDLLSWMESIIRQIETQ 1929
Query: 440 DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499
+ +S ++ L++ H+ +++ + + L + + S + + Q++
Sbjct: 1930 E-RPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988
Query: 500 DQWDALGSLTHSRREALEKTEKQLEAIDQLH--LEYAKRAAPFNNWMESAMEDLQDMFIV 557
+ R+E EK E + E + L ++++ A+ W+ + L
Sbjct: 1989 SR----------RKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
Query: 558 HTIEEIEGLISAHDQF-KSTLPDADR 582
HT++ +E LI H+ F KST A+R
Sbjct: 2039 HTVDSVEKLIKRHEAFEKSTASWAER 2064
Score = 37.4 bits (85), Expect = 0.064
Identities = 43/240 (17%), Positives = 90/240 (37%), Gaps = 40/240 (16%)
Query: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ-----------------------KASI 424
+HLEQ +G+ E + RL L E ++Q +
Sbjct: 800 EHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDA 859
Query: 425 HEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELD 484
E W KE L + TL D++ + + + + ++ +++ + A L E
Sbjct: 860 CELWMGEKEKWLAEMEMPD-TLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG 918
Query: 485 YYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWM 544
+ S V + +W A +L RREA++ + +H Y + W+
Sbjct: 919 HPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALR-------VH-NYCVDCEETSKWI 970
Query: 545 ---ESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESN 601
+E +D+ ++ G+I+ + D + + A+ +E+Q++ +S+
Sbjct: 971 TDKTKVVESTKDLG-----RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSH 1025
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
Length = 2564
Score = 409 bits (1051), Expect = e-114
Identities = 243/606 (40%), Positives = 354/606 (58%), Gaps = 32/606 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
E Q+KTFT W NSHL + G I ++ D RDG L LLEV+SGE+LP+P RG+MR+H
Sbjct: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVE-----ET 163
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
Query: 164 -SAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVT 222
SAK+ LLLWCQ KTA Y VN+QNF SW+DGLAFNALIHRHRP+L+++ KL K +
Sbjct: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
Query: 223 NLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 282
NL AF AE++L + ++LD ED VN PDEK+I+TYV SFYH FS + RI
Sbjct: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
KVL E ++E YE+LA++LL WI RT+ + ++ ++ +QQ+L+ F Y +
Sbjct: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
Query: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
KP K QEK LE+ ++Q+KLR NR F+P EG + DI+ W LE+AE E L
Sbjct: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
Query: 403 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
E+ R E+L+ LA++F K ++ E+W + + ++ +D L ++A ++KHEA E+D
Sbjct: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVS-QDNFGYELPAVEAAMKKHEAIEAD 477
Query: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQ 522
+AA+++RV+ +A +AQ L YYD V + + QW L L +RR LE Q
Sbjct: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLE----Q 533
Query: 523 LEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADR 582
A+ ++ E +WME L + E + L+ H + D
Sbjct: 534 NLALQKVFQEMVYMV----DWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEG---DIAA 586
Query: 583 EREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQS 642
+ E + A++ A R ++ L G Y PQ+I ++ V + A L+EQ+
Sbjct: 587 QSERVEALNAAALRFSQ-----LQG---YQPCDPQVICNRVNHVHGCL-----AELQEQA 633
Query: 643 KQQSNE 648
++ E
Sbjct: 634 ARRRAE 639
Score = 45.4 bits (106), Expect = 2e-04
Identities = 63/294 (21%), Positives = 123/294 (41%), Gaps = 29/294 (9%)
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
++LA ++E D +L + E RR P+ + MQ+ L F ++
Sbjct: 1828 QLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQL- 1886
Query: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
V + QL+ L+T + A E ++ GW+ L A
Sbjct: 1887 ---LVSQVRQLQEGAAQLRTVYAGEHAEAIASRE----QEVLQGWKELLSA--------- 1930
Query: 403 NEIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFE 460
E RL + A+ R + + + +W DG + + D + +S ++ L+ H+ +
Sbjct: 1931 CEDARLH-VSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSSVEVLMNYHQGLK 1988
Query: 461 SDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTE 520
++L A RV ++ QEL N + +I Q D LG+ E ++
Sbjct: 1989 TELEA---RVPELTT-CQELGRSLLL---NKSAMADEIQAQLDKLGTRKEEVSEKWDRHW 2041
Query: 521 KQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFK 574
+ L+ + ++H ++A+ A + W+ + LQ + +++E+E LI H+ F+
Sbjct: 2042 EWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFR 2094
Score = 42.4 bits (98), Expect = 0.002
Identities = 60/270 (22%), Positives = 110/270 (40%), Gaps = 36/270 (13%)
Query: 229 EVAEKYLDIPKML-------DAEDIVNTARPDEKAIMTYVSSFYHAFSGA---------Q 272
++ EK +P++ A + T R E + VS GA +
Sbjct: 1849 QIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGE 1908
Query: 273 KAETAANRICKVLAVNQENEHLMED---YEKLASDLLEW---IRRTIPWLEDRVPQKTIQ 326
AE A+R +VL +E ED + +D L + +R + W++ Q
Sbjct: 1909 HAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAA 1968
Query: 327 EMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNG 386
+ + + H+ K + LE L T L + + ++ M +I
Sbjct: 1969 DKPRDVSSVEVLMNYHQGLKTE----LEARVPELTTCQELGR--SLLLNKSAMADEIQAQ 2022
Query: 387 WQHL-EQAEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDGKEAMLKHRDYET 443
L + E+ E+W R E L + E +F Q+A + +AW +E +L+ R+ +
Sbjct: 2023 LDKLGTRKEEVSEKW----DRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGS 2078
Query: 444 ATLSDIKALIRKHEAFESDLAAHQDRVEQI 473
+ + +++ LIR+HEAF AA ++R +
Sbjct: 2079 S-VDEVEQLIRRHEAFRKAAAAWEERFSSL 2107
Score = 35.4 bits (80), Expect = 0.24
Identities = 59/277 (21%), Positives = 116/277 (41%), Gaps = 18/277 (6%)
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
LA+++ HL + KL L W R ++ + Q +++++Q L R+
Sbjct: 1168 LALDEWLPHLELGWHKL---LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSG 1224
Query: 345 PK-------VQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGY 397
+ V+E + +F T + + A +EG + G Q E +
Sbjct: 1225 AELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284
Query: 398 EEWLLNEIRRLERLDHLAEKFRQKASIHEAWT-DG--KEAMLKHRDYETATLSDIKALIR 454
E+ N++R + + L ++ + + + DG E ML RD +
Sbjct: 1285 EKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWL 1344
Query: 455 KHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRRE 514
+H+AF ++LA +++ +E+I Q+L + + +V + +I W L S T ++
Sbjct: 1345 RHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKAR 1404
Query: 515 ALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551
L + K DQL +A+ + MES ++D+
Sbjct: 1405 QLFEASK----ADQLVQSFAELDKKLLH-MESQLQDV 1436
Score = 32.0 bits (71), Expect = 2.7
Identities = 37/159 (23%), Positives = 64/159 (40%), Gaps = 16/159 (10%)
Query: 405 IRRLERLDHLAEKFRQKASIH--EAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
+RR D LA +R +H E W KE L + L D++ + + E+ + +
Sbjct: 872 LRRQWLRDALAV-YRMFGEVHACELWIGEKEQWLLSMRVPDS-LDDVEVVQHRFESLDQE 929
Query: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRRE-------- 514
+ + RV + QEL E + S V + + +W+ + L R+E
Sbjct: 930 MNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLV 989
Query: 515 ---ALEKTEKQLEAIDQLH-LEYAKRAAPFNNWMESAME 549
LE E + + ++ +E A RA W S +E
Sbjct: 990 ENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLE 1028
Score = 32.0 bits (71), Expect = 2.7
Identities = 31/161 (19%), Positives = 71/161 (44%), Gaps = 16/161 (9%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDAL 505
L ++ I+K++ ++ AH R+E++ A L L ++ V +++ W L
Sbjct: 1547 LQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGL 1606
Query: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNW-------MESAMEDLQDMFIVH 558
REA E+ ++ L+A Q+ +Y A W M S + + +
Sbjct: 1607 -------REAAERRQQVLDAAFQVE-QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 1658
Query: 559 TIEEIEGLISAHDQFKSTLPDADREREAILAI-HKEAQRIA 598
+++ L + ++ ++ R+ A+L + H ++++I+
Sbjct: 1659 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQIS 1699
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 338 bits (866), Expect = 2e-92
Identities = 201/533 (37%), Positives = 302/533 (56%), Gaps = 21/533 (3%)
Query: 50 KQQRKTFTAWCNSHLR--KAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVH 107
+ Q KTFT W N+ + +AG +I N+ + DG+ L+ LLE+ISGE LP P RG++RVH
Sbjct: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
Query: 108 KINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEET---- 163
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
Query: 164 -----SAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKD 218
S KE LL+WCQRKTA Y NVN+ +F SW DGL FNALIH HRP+L++Y LR D
Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
Query: 219 DPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAA 278
P+ NL AF VAE+ L I ++LD ED+ A+PDE++IMTYVS +YH S + +T
Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
Query: 279 NRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDY 338
R+ K+L QE E L YE+L +DLL WI LE R ++ M+Q L F +
Sbjct: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
Query: 339 RRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYE 398
R KPP++Q++ E LQT L+ NR F+P EG +++++ W LE AE
Sbjct: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
Query: 399 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEA 458
+ L + +L+RL+ LA +F+ KA++ E++ E +L A+L+ ++A +++
Sbjct: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
Query: 459 FESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEK 518
E+ + + R + +A IA L + Y+ +V R +++ +W L L H L+
Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL--LQH-----LQG 489
Query: 519 TEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHD 571
KQ+ A Q L + ++ +E E + + E+ L+ HD
Sbjct: 490 QRKQV-ADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHD 541
Score = 60.1 bits (144), Expect = 9e-09
Identities = 63/252 (25%), Positives = 114/252 (45%), Gaps = 38/252 (15%)
Query: 304 DLLEWIRRTI---PWLEDRVPQKTIQEMQQKLED-------FRDYRRVHKPPKVQEKCQL 353
+ LE+++R W++++ + + ++ Q LE R++R V + C
Sbjct: 2221 NFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280
Query: 354 EINFNTLQTKLRLSNRPAFMPSEGKMV----SDINNGWQHLEQAEKGYEEWLLN--EIRR 407
I+ +LQ K R P E K++ S +NN W Y++ L EI
Sbjct: 2281 SISDLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHV 2333
Query: 408 LER-LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466
L R LD++ ++ ++K ++ +A GK+ L ++ L+RKHE E ++
Sbjct: 2334 LSRELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPI 2381
Query: 467 QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTE--KQLE 524
Q +VE + L + +H + R Q++ + W L S RREAL+ ++L+
Sbjct: 2382 QAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQ 2441
Query: 525 AIDQLHLEYAKR 536
A+ Q L A+R
Sbjct: 2442 AMLQELLVSAQR 2453
Score = 58.2 bits (139), Expect = 4e-08
Identities = 84/401 (20%), Positives = 160/401 (39%), Gaps = 41/401 (10%)
Query: 313 IPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAF 372
+ W+ + +P + + L + R HK + Q+E+ + Q + LS+ +
Sbjct: 1498 LSWVAEHMPHGSPTSYTECLNGAQSLHRKHK------ELQVEVKAHQGQVQRVLSSGRSL 1551
Query: 373 MPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGK 432
S I Q LE E + L++ + F + + E W + K
Sbjct: 1552 AASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSEL-EGWVEEK 1610
Query: 433 EAMLKHRDY---ETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSH 489
++ RDY E ATL LI KH+A + +LA + +E++ AQ L + +
Sbjct: 1611 RPLVSSRDYGRDEAATLR----LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQ 1666
Query: 490 NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAME 549
V +++ +Q AL L +R +++LE +LH E+ + A W+ S +
Sbjct: 1667 RVVQ--ERLREQLRALQELAATR-------DRELEGTLRLH-EFLREAEDLQGWLASQKQ 1716
Query: 550 DLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSN 609
+ + E+ E + +F + + + A A+ + E H +
Sbjct: 1717 AAKGGESLG--EDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERGH----SAG 1770
Query: 610 PYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKM 669
P Q + + W ++ +L R HAL + ++ + + L +Q K
Sbjct: 1771 PMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQ--------VQEKA 1822
Query: 670 EEI-GRISIEMNGTLEDQLSHLKQYERSIVDYKPNL-DLLE 708
+ ++ ++ G LE QL + ER +V + L +LLE
Sbjct: 1823 TSLPNNVARDLCG-LEAQLRSHQGLERELVGTERQLQELLE 1862
Score = 50.4 bits (119), Expect = 7e-06
Identities = 80/408 (19%), Positives = 154/408 (37%), Gaps = 36/408 (8%)
Query: 348 QEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRR 407
Q + + ++ Q + L AF+ + D+ + L Q K E L
Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTA 2853
Query: 408 LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQ 467
LE L + FR A AW K + +DY + LS ++ L +H+ ES++++H+
Sbjct: 2854 LEARSLLLKFFRD-ADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
Query: 468 DRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAID 527
+ +L + ++ +H V R Q++ L + RR L++ ++ + +
Sbjct: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
Query: 528 QLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAI 587
+L +W+ L + H+ E + L+ + K R+ EA
Sbjct: 2972 EL--------LEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATK-------RDLEAF 3016
Query: 588 LAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE-QSKQQS 646
+ Q+ A + + +P Q + ++ + R H L E+ Q Q
Sbjct: 3017 SPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLE 3076
Query: 647 NEHLRRQFASQANVVGPWIQTK-----MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYK 701
E L ++ W+ TK ++ G+ +E LE++ ++ +S+ K
Sbjct: 3077 RETL---------LLDAWLTTKAATAESQDYGQ-DLEGVKVLEEKFDAFRKEVQSLGQAK 3126
Query: 702 PNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTI-ARTIN 748
+ L + ++ H I WE+L I ART N
Sbjct: 3127 --VYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/276 (23%), Positives = 109/276 (39%), Gaps = 49/276 (17%)
Query: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLS 447
Q L+ + ++WL E L++ + F + H+AW H D +
Sbjct: 1156 QELKVLWEQRQQWL-QEGLELQKFGREVDGFTATCANHQAWL--------HLDNLGEDVR 1206
Query: 448 DIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGS 507
+ +L+++H F L+ R E + A ++L + + +H V + Q I QW L
Sbjct: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
Query: 508 LTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI 567
+ RR +QL A QL E+ + A WME +GL+
Sbjct: 1267 RSEQRR-------RQLLASLQLQ-EWKQDVAELMQWMEE-----------------KGLM 1301
Query: 568 SAHD------QFKSTLPDADREREAILAIHKEAQRIAESNHIKLS----GSNPYTTVTPQ 617
+AH+ TL + +LA + + + + LS G T Q
Sbjct: 1302 AAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQT-RLQ 1360
Query: 618 IINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQ 653
+ SKWE + + + +R L +Q+ QQ E L RQ
Sbjct: 1361 GLRSKWEALNRKMTERGDEL--QQAGQQ--EQLLRQ 1392
Score = 48.1 bits (113), Expect = 4e-05
Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 31/268 (11%)
Query: 403 NEIRRLERLDHLA-EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFES 461
+E RR + L L ++++Q + W + K M H + +I +++HEA ES
Sbjct: 1268 SEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEP--SGARRNILQTLKRHEAAES 1325
Query: 462 DLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
+L A + VE + + +EL ++ TR Q + +W+AL R + L++ +
Sbjct: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
Query: 522 QLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD 581
Q + + QL + A E L E++EG + + + + L +
Sbjct: 1386 QEQLLRQL---------------QDAKEQL---------EQLEGALQSSETGQD-LRSSQ 1420
Query: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
R ++ + E++ +A + L+ +P I+ + +++L + H +
Sbjct: 1421 RLQKRHQQLESESRTLA-AKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGL 1479
Query: 642 SKQQSNEHLRRQFASQANVVGPWIQTKM 669
Q S E QF +N+ W+ M
Sbjct: 1480 QLQASVE--LHQFCHLSNMELSWVAEHM 1505
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/330 (19%), Positives = 139/330 (42%), Gaps = 36/330 (10%)
Query: 416 EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA 475
+ F Q++ W + +A L+ ++ + ++ + L+R+H+ ++ Q+R++Q+ A
Sbjct: 1070 QSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEIHLWQERLQQLDA 1128
Query: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
+Q + LD DS V + + Q L L R++ L++ +L+ + +
Sbjct: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQE-GLELQKFGREVDGFTA 1187
Query: 536 RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQ 595
A W+ +++L + + E L+ H +F L EA+ A +
Sbjct: 1188 TCANHQAWLH--LDNLGE-----DVREALSLLQQHREFGRLLSTLGPRAEALRA---HGE 1237
Query: 596 RIAESNHIKLSGSNPYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQ 653
++ +S H TV Q+ I ++W ++Q +R LL Q+ + +
Sbjct: 1238 KLVQSQHPAAH------TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE- 1290
Query: 654 FASQANVVGPWIQTKMEEIGRISI-EMNGTLEDQLSHLKQYERS---IVDYKPNLDLLEQ 709
+ MEE G ++ E +G + L LK++E + ++ + +++ L+Q
Sbjct: 1291 -----------LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQ 1339
Query: 710 QHQLIQEALIFDNKHTNYTMEHIRVGWEQL 739
+ + + ++ +R WE L
Sbjct: 1340 VGRELLSRRPCGQEDIQTRLQGLRSKWEAL 1369
Score = 43.9 bits (102), Expect = 7e-04
Identities = 67/316 (21%), Positives = 130/316 (41%), Gaps = 44/316 (13%)
Query: 391 EQAEKGYEEWLLNEIRRLERL--DHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD 448
+Q ++ Y+ W R+ ERL + + F ++ E +E LK ++ + +
Sbjct: 1994 DQRDQVYQTWA----RKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSS-VEE 2048
Query: 449 IKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSL 508
++ LIRKHE F L A QD+ E AA+ + L L V R + + + L
Sbjct: 2049 VEQLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKEL 2102
Query: 509 THSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLIS 568
SR AL + L + + A +W+++ + L++ + + +
Sbjct: 2103 AESRGHALHAS--------LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLL 2154
Query: 569 AHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQ 628
H F++ + E + ++ K+ + + +H + + Q + WE ++Q
Sbjct: 2155 KHQAFEA---EVQAHEEVMTSVAKKGEALLAQSHPRAG----EVSQRLQGLRKHWEDLRQ 2207
Query: 629 LVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMN-GTLEDQL 687
+ R L + ++ E L+R ++A WIQ K ++MN G L L
Sbjct: 2208 AMALRGQEL---EDRRNFLEFLQRVDLAEA-----WIQEK-------EVKMNVGDLGQDL 2252
Query: 688 SHLKQYERSIVDYKPN 703
H Q R + +++ N
Sbjct: 2253 EHCLQLRRRLREFRGN 2268
Score = 42.7 bits (99), Expect = 0.002
Identities = 45/187 (24%), Positives = 81/187 (43%), Gaps = 5/187 (2%)
Query: 349 EKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYE-EWLLNEIRR 407
++C+ E++ T L S + + SDI LEQ E W ++++
Sbjct: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
Query: 408 LERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQ 467
+ L+ + F E W KE L L+ ++ L+ KH+ E DL
Sbjct: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDP-LAPMEPLLWKHKMLEWDLEVQA 2594
Query: 468 DRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAID 527
++ + A A+ L++ + ++ + RCQ + + +AL +RR LE+ +QL+A
Sbjct: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEEL-RQLQAFL 2653
Query: 528 QLHLEYA 534
Q E A
Sbjct: 2654 QDSQEVA 2660
Score = 40.4 bits (93), Expect = 0.008
Identities = 50/270 (18%), Positives = 104/270 (38%), Gaps = 32/270 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDAL 505
L+++ L+++H+ E+ ++AH V +A EL+ + + + + +L
Sbjct: 530 LAEVVELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKARTLAQLQQSL 589
Query: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEG 565
+L +RR LE+T ++ E + E A W++ + + + + + +I G
Sbjct: 590 VALVRARRALLEQTLQRAEFLRNCEEEEA--------WLKECGQRVGNAALGRDLSQIAG 641
Query: 566 LISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTP----QIINS 621
+ H K+ + R + + + + + LS P T P + +
Sbjct: 642 ALQKH---KALEAEVHRHQAVCVDLVRRGR--------DLSARRPPTQPDPGERAEAVQG 690
Query: 622 KWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI-EMN 680
W+ +Q V R L L Q+ + A W++ + + R S +
Sbjct: 691 GWQLLQTRVVGRGARL--------QTALLVLQYFADAAEAASWLRERRSSLERASCGQDQ 742
Query: 681 GTLEDQLSHLKQYERSIVDYKPNLDLLEQQ 710
E L + ER + + L LE+Q
Sbjct: 743 AAAETLLRRHVRLERVLRAFAAELRRLEEQ 772
Score = 39.3 bits (90), Expect = 0.017
Identities = 39/169 (23%), Positives = 75/169 (44%), Gaps = 12/169 (7%)
Query: 313 IPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQ-EKCQLEINFNTLQTKLRLSNRPA 371
+ W ++R + +E+ + + H+ + +C+L+ + Q +L +
Sbjct: 3292 LAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQ-DLRQEGQQLVDNSH 3350
Query: 372 FMPSE-GKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 430
FM +E + + ++ Q LE+A W L R E +K RQ+ EAW
Sbjct: 3351 FMSAEVTECLQELEGRLQELEEA------WALRWQRCAESWG--LQKLRQRLEQAEAWLA 3402
Query: 431 GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQE 479
E +L DY + +SD++ L+ +H+ E LAA +++ Q+ E
Sbjct: 3403 CWEGLLLKPDYGHS-VSDVELLLHRHQDLEKLLAAQEEKFAQMQKTEME 3450
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 290 bits (741), Expect = 5e-78
Identities = 167/500 (33%), Positives = 278/500 (55%), Gaps = 19/500 (3%)
Query: 417 KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAA-HQDRVEQIAA 475
+F KA + E+W KE LK DY LS ++ L+ K E F++ L A Q+ + I A
Sbjct: 1980 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2038
Query: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
+ +L + S + R + +W L + + +R++ L + + ++ L L +AK
Sbjct: 2039 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2098
Query: 536 RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQ 595
+A+ FN+W E+A EDL D +++EEI+ L AHD F+S+L A + + + ++ +
Sbjct: 2099 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2158
Query: 596 RIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFA 655
+ SNPYT T + + W +Q+++ +R+ L +EQ +Q+ N+ LR++FA
Sbjct: 2159 SFRVA-------SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2211
Query: 656 SQANVVGPWIQTKMEEI--GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQL 713
AN WIQ + G +E +GTLE QL K+ + I + L +E
Sbjct: 2212 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2271
Query: 714 IQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRAS 773
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E ++EF
Sbjct: 2272 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2331
Query: 774 FNHFDKDHGGALGPEEFKACLISLGYDVENDRQGE--AEFNRIMSLVDPNHSGLVTFQAF 831
F HFDKD G L +EFK+CL SLGYD+ +GE EF I+ VDPN G V+ Q +
Sbjct: 2332 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2391
Query: 832 IDFM-SRETTDTDTADQVIASFKVLAGD-KNFITAEELRRELPPDQAEYCIARMAPY--- 886
+ FM SRET + +++++ ++F+ L+ + K ++T EEL + L +QA+YC++ M PY
Sbjct: 2392 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2451
Query: 887 QGPDAVPGALDYKSFSTALY 906
+G + +P A DY F+ +L+
Sbjct: 2452 KGRE-LPTAFDYVEFTRSLF 2470
Score = 85.5 bits (210), Expect = 2e-16
Identities = 121/611 (19%), Positives = 242/611 (39%), Gaps = 107/611 (17%)
Query: 193 KDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFE--VAEKYLDIPKMLDAEDIVNTA 250
KD + N L+ +H +L+E D +D + +LN+ + + D ++ D D +N
Sbjct: 1688 KDLASVNNLLKKH--QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGR 1745
Query: 251 RPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIR 310
K++ AA+R K+ H + + + D WI+
Sbjct: 1746 FQKIKSM-------------------AASRRAKL-----NESHRLHQFFRDMDDEESWIK 1781
Query: 311 RTIPWLEDRVPQKTIQEMQQKLEDF-RDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNR 369
+++ ED+ RD V K ++ + E+ ++
Sbjct: 1782 E--------------KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL----------AAHE 1817
Query: 370 PAFMP--SEGKMVSDINN-GWQHLEQAEKGY-EEWLLNEIRRL-----ERLDHLAE--KF 418
PA GK +SD N G + ++Q + E W E+++L +RL+ E +F
Sbjct: 1818 PAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESLEYQQF 1875
Query: 419 RQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478
EAW + K ++ DY TL+ I+ L++KHEAFE+D H+DRV + Q
Sbjct: 1876 VANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1934
Query: 479 ELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAA 538
+L + + + N++++ + + + L R+ L++ + L++ +A
Sbjct: 1935 DLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE--------NSAFLQFNWKAD 1986
Query: 539 PFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRE--------REAILAI 590
+W+ L+ + ++ L++ + F + L +E ++ +LA
Sbjct: 1987 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2046
Query: 591 HKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHL 650
+ E+ H L +W ++ R LLE QS + E L
Sbjct: 2047 KHVQSKAIEARHASLM--------------KRWSQLLANSAARKKKLLEAQSHFRKVEDL 2092
Query: 651 RRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ----YERSIVDYKPNLDL 706
FA +A+ W + E++ + N +++ L++ + S+ + + +
Sbjct: 2093 FLTFAKKASAFNSWFENAEEDL-TDPVRCNSL--EEIKALREAHDAFRSSLSSAQADFNQ 2149
Query: 707 LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQ 766
L + + I+ + N +T +TME + W L I E++ + ++ + +
Sbjct: 2150 LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEE---NDKL 2206
Query: 767 MQEFRASFNHF 777
QEF N F
Sbjct: 2207 RQEFAQHANAF 2217
Score = 68.2 bits (165), Expect = 3e-11
Identities = 105/493 (21%), Positives = 206/493 (41%), Gaps = 86/493 (17%)
Query: 302 ASDLLEWIRR---TIPWLEDRVPQKTIQEM----------QQKLEDFRDYRRVHKPPKVQ 348
A L++++R + W+ D+ T +E+ Q+K E+F+ H+ +V
Sbjct: 148 AQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVN 206
Query: 349 EKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRL 408
E N KL P + K ++N WQ L KG ++R
Sbjct: 207 E-------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQ 248
Query: 409 ERLDHLAEKFRQKASIHE--AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466
+L AE R + E +W KE ++ D+ L+ ++AL+RKHE E DLAA
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAAL 307
Query: 467 QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAI 526
+D+V+ + A A L + + + + +++ W+ + +L R L + +
Sbjct: 308 EDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR----- 362
Query: 527 DQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKS------TLPDA 580
++ + D +D + + E++ LI+A D+ S L D
Sbjct: 363 -----------------LQRFLADFRD--LTSWVTEMKALINA-DELASDVAGAEALLDR 402
Query: 581 DREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE- 639
+E + + H+++ + A+ + L + Y + + EK+ L +R ALLE
Sbjct: 403 HQEHKGEIDAHEDSFKSADESGQALLAAGHYAS------DEVREKLTVLSEER-AALLEL 455
Query: 640 -EQSKQQSNEHLRRQ-FASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSI 697
E +QQ + + Q F V W+ +E ++ ++ +L+ + LK++E
Sbjct: 456 WELRRQQYEQCMDLQLFYRDTEQVDNWM--SKQEAFLLNEDLGDSLDSVEALLKKHE--- 510
Query: 698 VDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTR 757
D++ +L E++ + E ++ +Y ME + + LL+ N + + + R
Sbjct: 511 -DFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLS----RRNALHERAMRR 565
Query: 758 DAKGISQEQMQEF 770
A+ +Q+F
Sbjct: 566 RAQLADSFHLQQF 578
Score = 62.8 bits (151), Expect = 1e-09
Identities = 90/441 (20%), Positives = 179/441 (40%), Gaps = 47/441 (10%)
Query: 294 LMEDYEKLA-SDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQ 352
++E KL S L+ R + +E + +K + +D + + H+ + E +
Sbjct: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFE-AE 1598
Query: 353 LEINFNTLQTKLRLSN----RPAFMPSEGKM---VSDINNGWQHLEQ--AEKGYEEWLLN 403
L N + ++ + + N R A SE + ++ + + WQ L Q AEK + L
Sbjct: 1599 LHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK---LK 1655
Query: 404 EIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL 463
E + + + + F + W EA+L DY L+ + L++KH+ E+D+
Sbjct: 1656 EANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK-DLASVNNLLKKHQLLEADI 1707
Query: 464 AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
+AH+DR++ + + A L +D+ V + I ++ + S+ SRR L ++ +
Sbjct: 1708 SAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR-- 1765
Query: 524 EAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRE 583
LH ++ + +W++ + + ++ L H + ++ L
Sbjct: 1766 -----LH-QFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELA---AH 1816
Query: 584 REAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSK 643
AI + +++++ N I G Q + W++++QL R L E
Sbjct: 1817 EPAIQGVLDTGKKLSDDNTI---GKEEIQQRLAQFV-EHWKELKQLAAARGQRLEESLEY 1872
Query: 644 QQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPN 703
Q QF + WI KM + S + TL LK++E D+ +
Sbjct: 1873 Q--------QFVANVEEEEAWINEKMTLVA--SEDYGDTLAAIQGLLKKHEAFETDFTVH 1922
Query: 704 LDLLEQQHQLIQEALIFDNKH 724
D + Q+ + +N H
Sbjct: 1923 KDRVNDVCTNGQDLIKKNNHH 1943
Score = 60.1 bits (144), Expect = 9e-09
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 9/137 (6%)
Query: 380 VSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHR 439
+ ++N W+ L+Q L E +L H ++F + A + W + K L
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 440 DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499
+Y L+ ++AL RKHE FE DLAA D+V + A+ L + + ++ +C ++
Sbjct: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 500 DQWDALGSLTHSRREAL 516
W +LG R+ L
Sbjct: 1319 QAWSSLGKRADQRKAKL 1335
Score = 58.5 bits (140), Expect = 3e-08
Identities = 62/301 (20%), Positives = 122/301 (40%), Gaps = 31/301 (10%)
Query: 416 EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA 475
++F + E W E L DY L++++ L +KH E+D+AAHQDR++ I
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
Query: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
A++ + ++D+ N+ + + + +++AL +R++ L D L L+
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL---------ADSLRLQQLF 790
Query: 536 R-AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA 594
R W+ + ++ L+ H ++ + I A+ ++
Sbjct: 791 RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG---HEPRIKAVTQKG 847
Query: 595 QRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQF 654
+ E H +N KWE ++ +R L E S Q +Q+
Sbjct: 848 NAMVEEGHFAAED----VKAKLHELNQKWEALKAKASQRRQDL--EDSLQ------AQQY 895
Query: 655 ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVD---YKPNLDLLEQQH 711
+ AN W++ K +G S + + + LK++E + D Y ++ L +Q
Sbjct: 896 FADANEAESWMREKEPIVG--STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQA 953
Query: 712 Q 712
Q
Sbjct: 954 Q 954
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/408 (18%), Positives = 157/408 (38%), Gaps = 47/408 (11%)
Query: 374 PSEGKMVSDINNGWQHLEQAEKGYEEWL-LNEIRRLERLDHLAEKFRQK-ASIHEAWTDG 431
PS K++ + + +Q Y + L+ +RR + D +F Q+ A E W
Sbjct: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
Query: 432 KEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNV 491
K + +Y+ T +++ ++KH+AFE+++ A+ + ++ + ++ S +
Sbjct: 63 KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 492 NTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551
TR ++ QW+ L + EK K L+A Q ++Y + +W+ +
Sbjct: 121 RTRLMELHRQWELL------LEKMREKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
Query: 552 QDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY 611
+ +E +E L ++F++ D E + +++ A ++ + H
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQT---DMAAHEERVNEVNQFAAKLIQEQH----PEEEL 225
Query: 612 TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTK--- 668
+N+ W++++ L +R L Q+ N + + WI+ K
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
Query: 669 --MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTN 726
++ GR + L + ER + + + L + +Q++
Sbjct: 278 MASDDFGRDLASVQALLRKH----EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
Query: 727 YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASF 774
E + WEQ+ T A R A+ ++Q F A F
Sbjct: 334 VKREELITNWEQIRTLAAE-----------RHARLNDSYRLQRFLADF 370
Score = 55.1 bits (131), Expect = 3e-07
Identities = 53/250 (21%), Positives = 105/250 (42%), Gaps = 19/250 (7%)
Query: 405 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
++R LD E F + E W +EA L D + +L ++ALI+KHE F+
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
Query: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQ 522
+ ++++ + A A +L +Y ++++R ++ D+W L + + +EK K
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL------KAQMIEKRSKL 1547
Query: 523 LEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTL-PDAD 581
E+ Q ++++ W+ ++ D I+ H F++ L +AD
Sbjct: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDP-TNIQSKHQKHQAFEAELHANAD 1604
Query: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
R R I + +R A +GS + +W+ + Q ++ L E
Sbjct: 1605 RIRGVIDMGNSLIERGA------CAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1658
Query: 642 SKQQSNEHLR 651
+Q N ++
Sbjct: 1659 KQQNFNTGIK 1668
Score = 52.4 bits (124), Expect = 2e-06
Identities = 75/369 (20%), Positives = 149/369 (40%), Gaps = 63/369 (17%)
Query: 406 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL 463
RR + D HL + FR + ++W + K Y+ S+++ ++KH+AFE++L
Sbjct: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
Query: 464 AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
+A+Q R++ + Q+L ++++Y V R ++ W ++ LE TE
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW----------KKLLEATE--- 668
Query: 524 EAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHD-----------Q 572
+ + L A + FN +E I + E+EG +++ D Q
Sbjct: 669 --LKGIKLREANQQQQFNRNVED---------IELWLYEVEGHLASDDYGKDLTNVQNLQ 717
Query: 573 FKSTLPDAD--REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV 630
K L +AD ++ I I +A++ ++ H +K Q+ +
Sbjct: 718 KKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENI---------------KKKQEAL 762
Query: 631 PKRDHALLEEQ--SKQQSNEHLR-RQFASQANVVGPWIQTKMEEIGRISIEMNGTL--ED 685
R AL E KQ+ + LR +Q WI+ K E I + + ++
Sbjct: 763 VARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTNRGKDLIGVQN 821
Query: 686 QLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIAR 745
L + + I ++P + + Q+ + E F + + + WE L ++
Sbjct: 822 LLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQ 881
Query: 746 TINEVENQI 754
++E+ +
Sbjct: 882 RRQDLEDSL 890
Score = 36.2 bits (82), Expect = 0.14
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 406 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLA 464
RR + D L A+++ A+ E+W KE ++ DY S +AL++KHEA SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDS-AEALLKKHEALMSDLS 940
Query: 465 AHQDRVEQIAAIAQELNE 482
A+ ++ + AQ +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958
Score = 34.7 bits (78), Expect = 0.42
Identities = 50/256 (19%), Positives = 101/256 (39%), Gaps = 52/256 (20%)
Query: 451 ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSHNVNTRCQKICDQWDAL 505
A ++K + +S A+ ++ +E+ +IA ++D ++ +V+ R +++ + + +L
Sbjct: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076
Query: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEG 565
L R+ LEK+ K+ + A W+ L + +E++E
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 566 LISAHDQFK-------STLPDA-----DREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
L D F+ S L D D E E ++A +A + E + T
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 614 VTP-----------------QIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFAS 656
+P + +N +W +QQL EE+S+ + H ++F
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLA--------EERSQLLGSAHEVQRFHR 1240
Query: 657 QANVVGPWIQTKMEEI 672
A+ WI+ K + +
Sbjct: 1241 DADETKEWIEEKNQAL 1256
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 290 bits (741), Expect = 5e-78
Identities = 167/500 (33%), Positives = 278/500 (55%), Gaps = 19/500 (3%)
Query: 417 KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAA-HQDRVEQIAA 475
+F KA + E+W KE LK DY LS ++ L+ K E F++ L A Q+ + I A
Sbjct: 1985 QFNWKADVVESWIGEKENSLKTDDYGR-DLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
Query: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
+ +L + S + R + +W L + + +R++ L + + ++ L L +AK
Sbjct: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
Query: 536 RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQ 595
+A+ FN+W E+A EDL D +++EEI+ L AHD F+S+L A + + + ++ +
Sbjct: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2163
Query: 596 RIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFA 655
+ SNPYT T + + W +Q+++ +R+ L +EQ +Q+ N+ LR++FA
Sbjct: 2164 SFRVA-------SNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
Query: 656 SQANVVGPWIQTKMEEI--GRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQL 713
AN WIQ + G +E +GTLE QL K+ + I + L +E
Sbjct: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
Query: 714 IQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRAS 773
++EALI DNK+T ++ + W+QL R + +E QI R+ G+++E ++EF
Sbjct: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
Query: 774 FNHFDKDHGGALGPEEFKACLISLGYDVENDRQGE--AEFNRIMSLVDPNHSGLVTFQAF 831
F HFDKD G L +EFK+CL SLGYD+ +GE EF I+ VDPN G V+ Q +
Sbjct: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
Query: 832 IDFM-SRETTDTDTADQVIASFKVLAGD-KNFITAEELRRELPPDQAEYCIARMAPY--- 886
+ FM SRET + +++++ ++F+ L+ + K ++T EEL + L +QA+YC++ M PY
Sbjct: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
Query: 887 QGPDAVPGALDYKSFSTALY 906
+G + +P A DY F+ +L+
Sbjct: 2457 KGRE-LPTAFDYVEFTRSLF 2475
Score = 85.5 bits (210), Expect = 2e-16
Identities = 121/611 (19%), Positives = 242/611 (39%), Gaps = 107/611 (17%)
Query: 193 KDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFE--VAEKYLDIPKMLDAEDIVNTA 250
KD + N L+ +H +L+E D +D + +LN+ + + D ++ D D +N
Sbjct: 1693 KDLASVNNLLKKH--QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGR 1750
Query: 251 RPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIR 310
K++ AA+R K+ H + + + D WI+
Sbjct: 1751 FQKIKSM-------------------AASRRAKL-----NESHRLHQFFRDMDDEESWIK 1786
Query: 311 RTIPWLEDRVPQKTIQEMQQKLEDF-RDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNR 369
+++ ED+ RD V K ++ + E+ ++
Sbjct: 1787 E--------------KKLLVGSEDYGRDLTGVQNLRKKHKRLEAEL----------AAHE 1822
Query: 370 PAFMP--SEGKMVSDINN-GWQHLEQAEKGY-EEWLLNEIRRL-----ERLDHLAE--KF 418
PA GK +SD N G + ++Q + E W E+++L +RL+ E +F
Sbjct: 1823 PAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESLEYQQF 1880
Query: 419 RQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478
EAW + K ++ DY TL+ I+ L++KHEAFE+D H+DRV + Q
Sbjct: 1881 VANVEEEEAWINEKMTLVASEDYGD-TLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1939
Query: 479 ELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAA 538
+L + + + N++++ + + + L R+ L++ + L++ +A
Sbjct: 1940 DLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDE--------NSAFLQFNWKAD 1991
Query: 539 PFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRE--------REAILAI 590
+W+ L+ + ++ L++ + F + L +E ++ +LA
Sbjct: 1992 VVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAA 2051
Query: 591 HKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHL 650
+ E+ H L +W ++ R LLE QS + E L
Sbjct: 2052 KHVQSKAIEARHASLM--------------KRWSQLLANSAARKKKLLEAQSHFRKVEDL 2097
Query: 651 RRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ----YERSIVDYKPNLDL 706
FA +A+ W + E++ + N +++ L++ + S+ + + +
Sbjct: 2098 FLTFAKKASAFNSWFENAEEDL-TDPVRCNSL--EEIKALREAHDAFRSSLSSAQADFNQ 2154
Query: 707 LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQ 766
L + + I+ + N +T +TME + W L I E++ + ++ + +
Sbjct: 2155 LAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEE---NDKL 2211
Query: 767 MQEFRASFNHF 777
QEF N F
Sbjct: 2212 RQEFAQHANAF 2222
Score = 68.2 bits (165), Expect = 3e-11
Identities = 105/493 (21%), Positives = 206/493 (41%), Gaps = 86/493 (17%)
Query: 302 ASDLLEWIRR---TIPWLEDRVPQKTIQEM----------QQKLEDFRDYRRVHKPPKVQ 348
A L++++R + W+ D+ T +E+ Q+K E+F+ H+ +V
Sbjct: 148 AQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQTDMAAHEE-RVN 206
Query: 349 EKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRL 408
E N KL P + K ++N WQ L KG ++R
Sbjct: 207 E-------VNQFAAKLIQEQHPEEELIKTKQ-DEVNAAWQRL----KGLA------LQRQ 248
Query: 409 ERLDHLAEKFRQKASIHE--AWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAH 466
+L AE R + E +W KE ++ D+ L+ ++AL+RKHE E DLAA
Sbjct: 249 GKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGR-DLASVQALLRKHEGLERDLAAL 307
Query: 467 QDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAI 526
+D+V+ + A A L + + + + +++ W+ + +L R L + +
Sbjct: 308 EDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYR----- 362
Query: 527 DQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKS------TLPDA 580
++ + D +D + + E++ LI+A D+ S L D
Sbjct: 363 -----------------LQRFLADFRD--LTSWVTEMKALINA-DELASDVAGAEALLDR 402
Query: 581 DREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE- 639
+E + + H+++ + A+ + L + Y + + EK+ L +R ALLE
Sbjct: 403 HQEHKGEIDAHEDSFKSADESGQALLAAGHYAS------DEVREKLTVLSEER-AALLEL 455
Query: 640 -EQSKQQSNEHLRRQ-FASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSI 697
E +QQ + + Q F V W+ +E ++ ++ +L+ + LK++E
Sbjct: 456 WELRRQQYEQCMDLQLFYRDTEQVDNWM--SKQEAFLLNEDLGDSLDSVEALLKKHE--- 510
Query: 698 VDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTR 757
D++ +L E++ + E ++ +Y ME + + LL+ N + + + R
Sbjct: 511 -DFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALLS----RRNALHERAMRR 565
Query: 758 DAKGISQEQMQEF 770
A+ +Q+F
Sbjct: 566 RAQLADSFHLQQF 578
Score = 60.1 bits (144), Expect = 9e-09
Identities = 37/137 (27%), Positives = 64/137 (46%), Gaps = 9/137 (6%)
Query: 380 VSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHR 439
+ ++N W+ L+Q L E +L H ++F + A + W + K L
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 440 DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499
+Y L+ ++AL RKHE FE DLAA D+V + A+ L + + ++ +C ++
Sbjct: 1260 NYGH-DLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 500 DQWDALGSLTHSRREAL 516
W +LG R+ L
Sbjct: 1319 QAWSSLGKRADQRKAKL 1335
Score = 59.3 bits (142), Expect = 2e-08
Identities = 72/340 (21%), Positives = 137/340 (40%), Gaps = 38/340 (11%)
Query: 387 WQHLEQ--AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETA 444
WQ L Q AEK + L E + + + + F + W EA+L DY
Sbjct: 1645 WQFLVQKSAEKSQK---LKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGK- 1693
Query: 445 TLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDA 504
L+ + L++KH+ E+D++AH+DR++ + + A L +D+ V + I ++
Sbjct: 1694 DLASVNNLLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQK 1753
Query: 505 LGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIE 564
+ S+ SRR L ++ + LH ++ + +W++ + + ++
Sbjct: 1754 IKSMAASRRAKLNESHR-------LH-QFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQ 1805
Query: 565 GLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWE 624
L H + ++ L AI + +++++ N I G Q + W+
Sbjct: 1806 NLRKKHKRLEAELA---AHEPAIQGVLDTGKKLSDDNTI---GKEEIQQRLAQFV-EHWK 1858
Query: 625 KVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLE 684
+++QL R L E Q QF + WI KM + S + TL
Sbjct: 1859 ELKQLAAARGQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVA--SEDYGDTLA 1908
Query: 685 DQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKH 724
LK++E D+ + D + Q+ + +N H
Sbjct: 1909 AIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHH 1948
Score = 58.5 bits (140), Expect = 3e-08
Identities = 62/301 (20%), Positives = 122/301 (40%), Gaps = 31/301 (10%)
Query: 416 EKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA 475
++F + E W E L DY L++++ L +KH E+D+AAHQDR++ I
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGK-DLTNVQNLQKKHALLEADVAAHQDRIDGITI 739
Query: 476 IAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAK 535
A++ + ++D+ N+ + + + +++AL +R++ L D L L+
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKL---------ADSLRLQQLF 790
Query: 536 R-AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA 594
R W+ + ++ L+ H ++ + I A+ ++
Sbjct: 791 RDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAG---HEPRIKAVTQKG 847
Query: 595 QRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQF 654
+ E H +N KWE ++ +R L E S Q +Q+
Sbjct: 848 NAMVEEGHFAAED----VKAKLHELNQKWEALKAKASQRRQDL--EDSLQ------AQQY 895
Query: 655 ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVD---YKPNLDLLEQQH 711
+ AN W++ K +G S + + + LK++E + D Y ++ L +Q
Sbjct: 896 FADANEAESWMREKEPIVG--STDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQA 953
Query: 712 Q 712
Q
Sbjct: 954 Q 954
Score = 56.2 bits (134), Expect = 1e-07
Identities = 48/250 (19%), Positives = 105/250 (42%), Gaps = 14/250 (5%)
Query: 405 IRRLERLDHLAEK--FRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
++R LD E F + E W +EA L D + +L ++ALI+KHE F+
Sbjct: 1435 VQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTED-KGDSLDSVEALIKKHEDFDKA 1493
Query: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQ 522
+ ++++ + A A +L +Y ++++R ++ D+W L + + +EK K
Sbjct: 1494 INVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRL------KAQMIEKRSKL 1547
Query: 523 LEAIDQLHLEYAKRAAPFNNWMESAMEDLQD-MFIVHTIEEIEGLISAHDQFKSTLPDAD 581
E+ Q ++++ W+ ++ D + T ++ L+S H + ++ +
Sbjct: 1548 GES--QTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQAFEAELH 1605
Query: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
+ I + + E +GS + +W+ + Q ++ L E
Sbjct: 1606 ANADRIRGVIDMGNSLIERG--ACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1663
Query: 642 SKQQSNEHLR 651
+Q N ++
Sbjct: 1664 KQQNFNTGIK 1673
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/408 (18%), Positives = 157/408 (38%), Gaps = 47/408 (11%)
Query: 374 PSEGKMVSDINNGWQHLEQAEKGYEEWL-LNEIRRLERLDHLAEKFRQK-ASIHEAWTDG 431
PS K++ + + +Q Y + L+ +RR + D +F Q+ A E W
Sbjct: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
Query: 432 KEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNV 491
K + +Y+ T +++ ++KH+AFE+++ A+ + ++ + ++ S +
Sbjct: 63 KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 492 NTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551
TR ++ QW+ L + EK K L+A Q ++Y + +W+ +
Sbjct: 121 RTRLMELHRQWELL------LEKMREKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
Query: 552 QDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY 611
+ +E +E L ++F++ D E + +++ A ++ + H
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQT---DMAAHEERVNEVNQFAAKLIQEQH----PEEEL 225
Query: 612 TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTK--- 668
+N+ W++++ L +R L Q+ N + + WI+ K
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
Query: 669 --MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTN 726
++ GR + L + ER + + + L + +Q++
Sbjct: 278 MASDDFGRDLASVQALLRKH----EGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
Query: 727 YTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASF 774
E + WEQ+ T A R A+ ++Q F A F
Sbjct: 334 VKREELITNWEQIRTLAAE-----------RHARLNDSYRLQRFLADF 370
Score = 52.4 bits (124), Expect = 2e-06
Identities = 75/369 (20%), Positives = 149/369 (40%), Gaps = 63/369 (17%)
Query: 406 RRLERLD--HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL 463
RR + D HL + FR + ++W + K Y+ S+++ ++KH+AFE++L
Sbjct: 565 RRAQLADSFHLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAEL 621
Query: 464 AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
+A+Q R++ + Q+L ++++Y V R ++ W ++ LE TE
Sbjct: 622 SANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLW----------KKLLEATE--- 668
Query: 524 EAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHD-----------Q 572
+ + L A + FN +E I + E+EG +++ D Q
Sbjct: 669 --LKGIKLREANQQQQFNRNVED---------IELWLYEVEGHLASDDYGKDLTNVQNLQ 717
Query: 573 FKSTLPDAD--REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLV 630
K L +AD ++ I I +A++ ++ H +K Q+ +
Sbjct: 718 KKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENI---------------KKKQEAL 762
Query: 631 PKRDHALLEEQ--SKQQSNEHLR-RQFASQANVVGPWIQTKMEEIGRISIEMNGTL--ED 685
R AL E KQ+ + LR +Q WI+ K E I + + ++
Sbjct: 763 VARYEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREK-EPIAASTNRGKDLIGVQN 821
Query: 686 QLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIAR 745
L + + I ++P + + Q+ + E F + + + WE L ++
Sbjct: 822 LLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQ 881
Query: 746 TINEVENQI 754
++E+ +
Sbjct: 882 RRQDLEDSL 890
Score = 36.2 bits (82), Expect = 0.14
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 406 RRLERLDHL-AEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLA 464
RR + D L A+++ A+ E+W KE ++ DY S +AL++KHEA SDL+
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDS-AEALLKKHEALMSDLS 940
Query: 465 AHQDRVEQIAAIAQELNE 482
A+ ++ + AQ +
Sbjct: 941 AYGSSIQALREQAQSCRQ 958
Score = 34.7 bits (78), Expect = 0.42
Identities = 50/256 (19%), Positives = 101/256 (39%), Gaps = 52/256 (20%)
Query: 451 ALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYY-----DSHNVNTRCQKICDQWDAL 505
A ++K + +S A+ ++ +E+ +IA ++D ++ +V+ R +++ + + +L
Sbjct: 1019 AYVKKLDPAQS--ASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSL 1076
Query: 506 GSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEG 565
L R+ LEK+ K+ + A W+ L + +E++E
Sbjct: 1077 LELGEKRKGMLEKSCKKFMLF--------REANELQQWINEKEAALTSEEVGADLEQVEV 1128
Query: 566 LISAHDQFK-------STLPDA-----DREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
L D F+ S L D D E E ++A +A + E + T
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 614 VTP-----------------QIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFAS 656
+P + +N +W +QQL EE+S+ + H ++F
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLA--------EERSQLLGSAHEVQRFHR 1240
Query: 657 QANVVGPWIQTKMEEI 672
A+ WI+ K + +
Sbjct: 1241 DADETKEWIEEKNQAL 1256
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 253 bits (645), Expect = 7e-67
Identities = 155/427 (36%), Positives = 236/427 (55%), Gaps = 28/427 (6%)
Query: 18 AGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDED 77
+G GAG GS+ D + + + ++ Q+KTFT W N HL KA I ++ ED
Sbjct: 42 SGGGAGSNGSVLDPAERAV-----IRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYED 96
Query: 78 FRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDG 137
RDG L+ LLEV+SG+ LP+ E+G+MR HK+ NV ALD++ + VKLV+I ++I DG
Sbjct: 97 LRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADG 155
Query: 138 NAKMTLGMIWTIILRFAIQDISV----EETSAKEGLLLWCQRKTAPYKNVNVQNFHISWK 193
N K+TLG+IWTIIL F I DI V E+ +AKE LLLW QR Y+ + NF SW+
Sbjct: 156 NPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWR 215
Query: 194 DGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPD 253
DG FNA+IHRH+P LI+ +K+ + + NL+ AF VAE+ L + ++LD ED V+ +PD
Sbjct: 216 DGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED-VDVPQPD 274
Query: 254 EKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTI 313
EK+I+TYVSS Y A + E + ++Y +L LL+W+R
Sbjct: 275 EKSIITYVSSLYDAMPRVPDVQDGVRA--------NELQLRWQEYRELVLLLLQWMRHHT 326
Query: 314 PWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKL---RLSNRP 370
E+R + +E++ F ++ + P K +K + + + +L+ + +L P
Sbjct: 327 AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 386
Query: 371 AFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTD 430
+ P D+ W L A E+ L +E RLE L + K + +A + E +
Sbjct: 387 GYHP------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLN 440
Query: 431 GKEAMLK 437
+A+L+
Sbjct: 441 QADALLQ 447
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2409
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2410 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2468
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2469 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2528
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2645
Query: 753 QI 754
Q+
Sbjct: 2646 QV 2647
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 1962
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 2023 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2082
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2083 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2142
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2143 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2202
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2203 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2262
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2263 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2316
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2317 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2359
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2360 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2420 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2479
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2480 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2535
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1115 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1174
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1175 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1294
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1295 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1354
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1355 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1414
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1472
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1473 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1530
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1531 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1585
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 251 bits (640), Expect = 3e-66
Identities = 153/416 (36%), Positives = 231/416 (55%), Gaps = 31/416 (7%)
Query: 29 GDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLL 88
G AQ++ +RD + Q+KTFT W N HL KA I ++ ED RDG L+ LL
Sbjct: 29 GRRWAQDEQDERD--------RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLL 80
Query: 89 EVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWT 148
EV+SG+ LP+ E+G+MR HK+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWT
Sbjct: 81 EVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWT 139
Query: 149 IILRFAIQDISV----EETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHR 204
IIL F I DI V E+ +AKE LLLW QR Y+ + NF SW+DG FNA+IHR
Sbjct: 140 IILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHR 199
Query: 205 HRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSF 264
H+P LI+ +K+ + + NL+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS
Sbjct: 200 HKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSL 258
Query: 265 YHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT 324
Y A + E + ++Y +L LL+W+R E+R +
Sbjct: 259 YDAMPRVPDVQDGVRA--------NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSS 310
Query: 325 IQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVS 381
+E++ F ++ + P K +K + + + +L+ + +L P + P
Sbjct: 311 FEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------L 364
Query: 382 DINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
D+ W L A E+ L +E RLE L + K + +A + E + +A+L+
Sbjct: 365 DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 420
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2441
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2618
Query: 753 QI 754
Q+
Sbjct: 2619 QV 2620
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 1935
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2236 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2290 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1445
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1504 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1558
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 250 bits (638), Expect = 5e-66
Identities = 148/396 (37%), Positives = 224/396 (56%), Gaps = 23/396 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 41 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 99
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 100 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 159
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW QR Y+ + NF SW+DG FNA+IHRH+P LI+ +K+ + + NL
Sbjct: 160 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 219
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS Y A +
Sbjct: 220 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 274
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
E + ++Y +L LL+W+R E+R + +E++ F ++ + P
Sbjct: 275 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 330
Query: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
K +K + + + +L+ + +L P + P D+ W L A E+ L
Sbjct: 331 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 384
Query: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+E RLE L + K + +A + E + +A+L+
Sbjct: 385 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 420
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2382
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2441
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2442 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2618
Query: 753 QI 754
Q+
Sbjct: 2619 QV 2620
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 1935
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 1996 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2055
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2056 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2115
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2116 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2175
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2176 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2235
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2236 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2289
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2290 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2332
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2333 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2393 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2452
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2453 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1088 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1147
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1148 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1267
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1268 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1327
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1328 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1387
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1445
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1504 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1558
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 250 bits (638), Expect = 5e-66
Identities = 148/396 (37%), Positives = 224/396 (56%), Gaps = 23/396 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 45 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 103
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 104 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 163
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW QR Y+ + NF SW+DG FNA+IHRH+P LI+ +K+ + + NL
Sbjct: 164 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 223
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS Y A +
Sbjct: 224 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 278
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
E + ++Y +L LL+W+R E+R + +E++ F ++ + P
Sbjct: 279 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 334
Query: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
K +K + + + +L+ + +L P + P D+ W L A E+ L
Sbjct: 335 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 388
Query: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+E RLE L + K + +A + E + +A+L+
Sbjct: 389 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 424
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2386
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2445
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2446 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2505
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2622
Query: 753 QI 754
Q+
Sbjct: 2623 QV 2624
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 1939
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 2000 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2059
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2060 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2119
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2120 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2179
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2180 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2239
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2240 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2293
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2294 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2336
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2337 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2397 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2456
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2457 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1092 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1151
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1152 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1271
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1272 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1331
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1332 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1391
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1449
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1508 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1562
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 250 bits (638), Expect = 5e-66
Identities = 148/396 (37%), Positives = 224/396 (56%), Gaps = 23/396 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 9 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 67
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 68 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 127
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW QR Y+ + NF SW+DG FNA+IHRH+P LI+ +K+ + + NL
Sbjct: 128 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 187
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS Y A +
Sbjct: 188 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 242
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
E + ++Y +L LL+W+R E+R + +E++ F ++ + P
Sbjct: 243 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 298
Query: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
K +K + + + +L+ + +L P + P D+ W L A E+ L
Sbjct: 299 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 352
Query: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+E RLE L + K + +A + E + +A+L+
Sbjct: 353 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 388
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2350
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2409
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2410 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2469
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2529
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2586
Query: 753 QI 754
Q+
Sbjct: 2587 QV 2588
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 1903
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 1964 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2023
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2024 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2083
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2084 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2143
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2144 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2203
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2204 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2257
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2258 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2300
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2301 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2361 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2420
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2421 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1056 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1115
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1116 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1235
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1236 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1295
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1296 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1355
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1413
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1414 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1472 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1526
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 250 bits (638), Expect = 5e-66
Identities = 148/396 (37%), Positives = 224/396 (56%), Gaps = 23/396 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 178 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 236
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 237 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 296
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW QR Y+ + NF SW+DG FNA+IHRH+P LI+ +K+ + + NL
Sbjct: 297 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 356
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS Y A +
Sbjct: 357 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 411
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
E + ++Y +L LL+W+R E+R + +E++ F ++ + P
Sbjct: 412 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 467
Query: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
K +K + + + +L+ + +L P + P D+ W L A E+ L
Sbjct: 468 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 521
Query: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+E RLE L + K + +A + E + +A+L+
Sbjct: 522 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 557
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2519
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2578
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2579 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2638
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2755
Query: 753 QI 754
Q+
Sbjct: 2756 QV 2757
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 2072
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 2133 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2192
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2193 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2252
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2253 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2312
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2313 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2372
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2373 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2426
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2427 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2469
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2590 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1225 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1284
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1285 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1404
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1405 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1464
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1524
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1582
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1583 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1641 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1695
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 250 bits (638), Expect = 5e-66
Identities = 148/396 (37%), Positives = 224/396 (56%), Gaps = 23/396 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 19 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 77
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 78 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 137
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW QR Y+ + NF SW+DG FNA+IHRH+P LI+ +K+ + + NL
Sbjct: 138 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 197
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS Y A +
Sbjct: 198 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 252
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
E + ++Y +L LL+W+R E+R + +E++ F ++ + P
Sbjct: 253 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 308
Query: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
K +K + + + +L+ + +L P + P D+ W L A E+ L
Sbjct: 309 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 362
Query: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+E RLE L + K + +A + E + +A+L+
Sbjct: 363 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 398
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2360
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2419
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2420 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2479
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2596
Query: 753 QI 754
Q+
Sbjct: 2597 QV 2598
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 1913
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 1974 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2033
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2034 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2093
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2094 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2153
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2154 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2213
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2214 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2267
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2268 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2310
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2431 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1066 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1125
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1126 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1245
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1246 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1305
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1365
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1423
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1424 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1482 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1536
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 250 bits (638), Expect = 5e-66
Identities = 148/396 (37%), Positives = 224/396 (56%), Gaps = 23/396 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
++ Q+KTFT W N HL KA I ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 27 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 85
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 86 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 145
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW QR Y+ + NF SW+DG FNA+IHRH+P LI+ +K+ + + NL
Sbjct: 146 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 205
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS Y A +
Sbjct: 206 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 260
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
E + ++Y +L LL+W+R E+R + +E++ F ++ + P
Sbjct: 261 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 316
Query: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
K +K + + + +L+ + +L P + P D+ W L A E+ L
Sbjct: 317 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 370
Query: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+E RLE L + K + +A + E + +A+L+
Sbjct: 371 RSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQ 406
Score = 43.5 bits (101), Expect = 9e-04
Identities = 71/362 (19%), Positives = 144/362 (39%), Gaps = 25/362 (6%)
Query: 411 LDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRV 470
L AEK +Q A + + + R L+ +AL K + R+
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 471 EQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALE-KTEKQLEA---I 526
+ A + Q+ EL + + +++ Q L T + LE + ++QLE
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQ---LAEETQGFQRTLEAERQRQLEMSAEA 2368
Query: 527 DQLHLEYAKR----------AAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKST 576
++L L A+ A F E E L + T E++ + + Q + +
Sbjct: 2369 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQS 2427
Query: 577 LPDADREREAILAIHKEAQRI-AESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDH 635
DA+R REAI + +E +++ E+ ++L T Q++ Q + ++D
Sbjct: 2428 DHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDS 2487
Query: 636 ALLEEQSKQQSNEHLRRQF---ASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692
L E+ +Q L + F ++A + Q + +++ + + ++E+ +
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2547
Query: 693 YERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
E + + L LEQQ + +E L +N+ E +++ EQ +A + +
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHSEEVTAS 2604
Query: 753 QI 754
Q+
Sbjct: 2605 QV 2606
Score = 40.8 bits (94), Expect = 0.006
Identities = 119/656 (18%), Positives = 241/656 (36%), Gaps = 95/656 (14%)
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
R L E K D L + ++ L+ K L ED + R E+ I+ +SF
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGL-VEDTLRQRRQVEEEILALKASFE 1921
Query: 266 HAFSGAQKAETAANRICK----VLAVNQENE-------HLMEDYEKLASDLLEWIRRTIP 314
A +G + E RI L ++ E L + E+ + E +++++
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 315 WLEDRVPQK--TIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRP-- 370
E+ Q+ ++E+++ + RR+ + + + QL++ Q +L+ +
Sbjct: 1982 AEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA 2041
Query: 371 -AFMPSEGKMVSDINNGWQHLEQ-----------AEKGYEEWLLNE------IRRLERLD 412
A E ++ + L+Q AE+ E + E R++E +
Sbjct: 2042 FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE 2101
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDI-KALIRKHEAFESDLAAHQDRVE 471
L + ++A E + K + E A + +A +R+ +A ++++ H+ E
Sbjct: 2102 RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAE 2161
Query: 472 QI----AAIAQELNELDY------YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEK 521
Q A + QEL L + + ++ Q++ + E L
Sbjct: 2162 QTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRV 2221
Query: 522 QLEAIDQL--HLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPD 579
Q+E + +L +E RA + +D F+ E+++ + + +
Sbjct: 2222 QMEELSKLKARIEAENRALILRD------KDNTQRFLQEEAEKMKQVAEEAARLSVAAQE 2275
Query: 580 ADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE 639
A R R+ LA AQ+ A + +++ K + VQ+ + A L
Sbjct: 2276 AARLRQ--LAEEDLAQQRA---------------LAEKMLKEKMQAVQEATRLKAEAELL 2318
Query: 640 EQSKQQSNEHLRR------QFASQANVVGPWIQTKMEEIGRISIEMN------------- 680
+Q K+ + E RR Q A Q Q +E + +EM+
Sbjct: 2319 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378
Query: 681 ----GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGW 736
E+ ++ I + +L Q+ + + L + +++ E +R
Sbjct: 2379 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2438
Query: 737 EQLLTTIARTINEVE-NQILTRDAKGISQEQ-MQEFRASFNHFDKDHGGALGPEEF 790
+L + E + Q+ + + + + QEQ +QE +A F + L E F
Sbjct: 2439 AELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2494
Score = 34.7 bits (78), Expect = 0.42
Identities = 89/479 (18%), Positives = 173/479 (36%), Gaps = 55/479 (11%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1074 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1133
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1134 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193
Query: 562 EIEGLISAHDQFKSTLPDADREREAILA----------------------IHKEAQRIAE 599
++ + D + L DA R +E I A I + +++ E
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE 1253
Query: 600 SNHIKLSGSNPYTTVTPQIINSKWEKVQQLVP-KRDHALLEEQSKQQSNEHLRRQFASQA 658
N Q++ K + P K+ +S Q LR ++
Sbjct: 1254 CQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELT 1313
Query: 659 NVVGPWIQ------TKMEEIGRISIEMNGTLEDQLSHLK---QYERSIVDYKPNLDL--- 706
+ +I+ +MEE R++ + ++L+ ++ + +R + +
Sbjct: 1314 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE 1373
Query: 707 --LEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGIS- 763
++ Q +QE ++ + + R E+L R +E E Q R A+
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQ--LRQSSEAEIQAKARQAEAAER 1431
Query: 764 -----QEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGEAEFNRIMSLV 818
+E+++ R ++ GGA G E +A RQ + E R+ V
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEG--ELQALRARAEEAEAQKRQAQEEAERLRRQV 1489
Query: 819 DPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAE 877
QA ++ SR + + A + + + L ++ + AEE R L + E
Sbjct: 1490 QDESQR--KRQAEVELASRVKAEAEAAREKQRALQAL--EELRLQAEEAERRLRQAEVE 1544
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
sapiens]
Length = 1369
Score = 246 bits (628), Expect = 7e-65
Identities = 147/396 (37%), Positives = 222/396 (56%), Gaps = 23/396 (5%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
++ Q+KT T W N HL KA I ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR HK
Sbjct: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW QR Y+ + NF SW+DG FNA+IHRH+P LI+ +K+ + + NL
Sbjct: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+ AF VAE+ L + ++LD ED V+ +PDEK+I+TYVSS Y A +
Sbjct: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
E + ++Y +L LL+W+R E+R + +E++ F ++ + P
Sbjct: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463
Query: 345 PKVQEKCQLEINFNTLQTKL---RLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWL 401
K +K + + + +L+ + +L P + P D+ W L A E+ L
Sbjct: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517
Query: 402 LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLK 437
+E RLE L + K + +A + E +A+L+
Sbjct: 518 RSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQ 553
Score = 30.8 bits (68), Expect = 6.0
Identities = 34/149 (22%), Positives = 62/149 (41%), Gaps = 4/149 (2%)
Query: 446 LSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQ--WD 503
L I +IR + E L AH++++++ A+ L EL+ + R Q Q +D
Sbjct: 1221 LKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFD 1280
Query: 504 ALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAP-FNNWME-SAMEDLQDMFIVHTIE 561
AL +E E+ +++ D + +R A W A D++ +
Sbjct: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1340
Query: 562 EIEGLISAHDQFKSTLPDADREREAILAI 590
++ + D + L DA R +E I A+
Sbjct: 1341 QLRYYRESADPLGAWLQDARRRQEQIQAM 1369
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 243 bits (621), Expect = 5e-64
Identities = 141/382 (36%), Positives = 216/382 (56%), Gaps = 18/382 (4%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR H+
Sbjct: 63 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 121
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 122 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 181
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW Q+ T Y + +NF W+DG FNA+IH++RP+LI+ + + + NL
Sbjct: 182 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 241
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+AF VAEK + + ++LD ED V+ + PDEK+++TYVSS Y AF +
Sbjct: 242 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 292
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
+ N +E Y+ + + L++WIR + + +R E++ + ++ P
Sbjct: 293 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 351
Query: 345 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNE 404
PK EK +++ + L+ + +G +DI W L A E+ L E
Sbjct: 352 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 408
Query: 405 IRRLERLDHLAEKFRQKASIHE 426
+ RLE L +A + ++ + I E
Sbjct: 409 VERLEMLQQIANRVQRDSVICE 430
Score = 56.2 bits (134), Expect = 1e-07
Identities = 102/522 (19%), Positives = 209/522 (40%), Gaps = 65/522 (12%)
Query: 216 RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAE 275
++ + + + ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4139 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4198
Query: 276 TAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT-IQEMQQKLED 334
+RI K+ +E Y+ + +W+ L P T ++ ++Q++E+
Sbjct: 4199 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4252
Query: 335 FRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAE 394
+ ++ E Q +I L + L + S+ V D L+
Sbjct: 4253 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIW 4301
Query: 395 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIR 454
EE ++N +LE +F+ AW E +L + I+ +
Sbjct: 4302 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4361
Query: 455 KHEAFESDLAAHQDRVEQIAAIAQELNELDY-YDSHNVNTRCQKICDQWDALGSLTHSRR 513
KH ++D+ AHQ VE + +L E ++ N+ + + + +W +
Sbjct: 4362 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW----------Q 4411
Query: 514 EALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQF 573
LEKTE++ + +D ++A F+ +EDLQ + + E + A
Sbjct: 4412 NVLEKTEQRKQQLDGA----LRQAKGFHG----EIEDLQQW-----LTDTERHLLASKPL 4458
Query: 574 KSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKR 633
LP+ +E+ L +H E E+ + S +K QQ++ +
Sbjct: 4459 GG-LPETAKEQ---LNVHMEVCAAFEAKE--------------ETYKSLMQKGQQMLARC 4500
Query: 634 DHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQY 693
+ E + Q +L+ ++ S + +TK+EE +++E + +L+D ++ L Q
Sbjct: 4501 PKSA--ETNIDQDINNLKEKWESVETKLNER-KTKLEEALNLAMEFHNSLQDFINWLTQA 4557
Query: 694 ERSI-VDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRV 734
E+++ V +P+L +L+ I E +F N+ ++ + I +
Sbjct: 4558 EQTLNVASRPSL-ILDTVLFQIDEHKVFANEVNSHREQIIEL 4598
Score = 44.7 bits (104), Expect = 4e-04
Identities = 87/500 (17%), Positives = 207/500 (41%), Gaps = 53/500 (10%)
Query: 303 SDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRR-----------VHKPPKVQEKC 351
SD +WI + I ++ Q ++ + KL D + +++ + +K
Sbjct: 2668 SDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM 2725
Query: 352 QLEINFNTLQTKLR--LSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLE 409
+ EI Q K+ L + + E + ++++ + + ++ K E+ N ++ L+
Sbjct: 2726 KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQ 2785
Query: 410 RLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR 469
+ +F+Q + +AW D K+ +A L +++LI+ H+ F L A
Sbjct: 2786 SACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2845
Query: 470 VEQIAAIAQE-LNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQ 528
E+ A + L + + + + I WD ++ E+ K E++++
Sbjct: 2846 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NKQVKERENKLKESLEK 2899
Query: 529 LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAIL 588
L+Y ++ W++ +L+++ E E I+ + KS + D+ +
Sbjct: 2900 A-LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHFGMVE 2955
Query: 589 AIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNE 648
++ A + + +++ ++ + L+ K D + SK+ E
Sbjct: 2956 LLNNTANSLLS-----------VCEIDKEVVT---DENKSLIQKVDMVTEQLHSKKFCLE 3001
Query: 649 HLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQ------LSHLKQYERSIVDYKP 702
++ ++F V + + + ++++ +L Q L+ L+ ++S+ K
Sbjct: 3002 NMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3059
Query: 703 NLDLLEQQHQ-LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTR-DAK 760
+DL ++ Q L+ EA D+K T+ + + Q +T+++ ++E + + T+
Sbjct: 3060 QVDLAKRLAQDLVVEA--SDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQGI 3116
Query: 761 GISQEQMQEFRASFNHFDKD 780
G Q ++E + F FD +
Sbjct: 3117 GHFQNTIREMFSQFAEFDDE 3136
Score = 44.7 bits (104), Expect = 4e-04
Identities = 99/540 (18%), Positives = 211/540 (39%), Gaps = 88/540 (16%)
Query: 261 VSSFYHAFSGAQKAETAANRICKVLAVNQENEH----LMEDYEKLASDLLEWIRRTIPWL 316
+ +F + AN+ CK++ +E + D E L+ + + R
Sbjct: 3157 IKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQA-R 3215
Query: 317 EDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM--- 373
E++V + TI+ +++ +++ + + + E+ Q + T +L+ F
Sbjct: 3216 EEQV-EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3274
Query: 374 --PSEGKMVSDINNGWQHLEQAE------KGYEE--------WLLNEIRRLERLDHLAE- 416
P +GK D+N Q L Q+ +G E W + +R L E
Sbjct: 3275 IEPLQGKQ-QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3333
Query: 417 -----KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVE 471
+F+ +W E ++ ++ +A +KA I++ + + L + VE
Sbjct: 3334 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3393
Query: 472 QIAAIAQEL-NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLH 530
I +++ + D + + + +W+AL + +R +QLE I +
Sbjct: 3394 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVA 3446
Query: 531 LEYAKRAAPFNNWMESAMEDLQDMFIVHT-IEEIEGLISAHDQFKSTLPDADREREAILA 589
++ + P N W+ + + L + + T ++E I+ H + + + ++ ++
Sbjct: 3447 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3506
Query: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEK--VQQLVPKRDHALLEEQSKQQSN 647
I + ++++S+ +K VQ + +E Q K S
Sbjct: 3507 IGQSL----------------------KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR 3544
Query: 648 EHLRRQFASQANVVGP-------WIQTKMEEIGRISIEMNGT--LEDQLSHLKQYERSIV 698
L +Q A + G W+ +++ ++S++ T L Q S L+ + I+
Sbjct: 3545 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3604
Query: 699 DYKPNLD--LLEQQHQLIQ----EALIFDNKHTNYTMEHIRVGWE---QLLTTIARTINE 749
K N+D LL L Q E LI +K +E I+ ++ +L T +A+T+ +
Sbjct: 3605 LRKQNVDQALLNGLELLKQTTGDEVLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3659
Score = 43.5 bits (101), Expect = 9e-04
Identities = 65/334 (19%), Positives = 122/334 (36%), Gaps = 50/334 (14%)
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQ---EMQQKLEDFRDYR 339
KV+ E ++D K A E + + WLE+ +K++ E+ + +
Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4687
Query: 340 RVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGK---MVSDINNGWQHL----EQ 392
HK + + + T +T L + + K M+S++ + W + +
Sbjct: 4688 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4747
Query: 393 AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
+ EE LL + + L L + W E L + + L
Sbjct: 4748 RQNKLEEALLFSGQFTDALQALID-----------WLYRVEPQLAEDQPVHGDIDLVMNL 4796
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
I H+AF+ +L V+ + A+EL E DS V + Q++ +W+ + +L+ S+
Sbjct: 4797 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4856
Query: 513 REALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQ 572
+ LE +Q E E+ W+ A + L+
Sbjct: 4857 QTRLEAALRQAE-------EFHSVVHALLEWLAEAEQTLR-------------------- 4889
Query: 573 FKSTLPDADREREAILAIHKEAQRIAESNHIKLS 606
F LPD + ++ HKE + E +L+
Sbjct: 4890 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELN 4923
Score = 42.0 bits (97), Expect = 0.003
Identities = 49/273 (17%), Positives = 116/273 (42%), Gaps = 29/273 (10%)
Query: 490 NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAME 549
N++ + ++W+++ + + R+ LE EA++ L +E+ F NW+ A +
Sbjct: 4507 NIDQDINNLKEKWESVETKLNERKTKLE------EALN-LAMEFHNSLQDFINWLTQAEQ 4559
Query: 550 DLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSN 609
L I ++ ++ D+ K + + RE I+ + K H+K
Sbjct: 4560 TLNVASRPSLI--LDTVLFQIDEHKVFANEVNSHREQIIELDKTG------THLKYFSQK 4611
Query: 610 PYTTVTPQI---INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQ 666
+ + + S+WEKV Q + +R +L + + + +QF + + W++
Sbjct: 4612 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR-------AKQFHEAWSKLMEWLE 4664
Query: 667 TKMEEI-GRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE--ALIFDN 722
+ + + I + ++ QL+ K++++S+ D + + ++E +L DN
Sbjct: 4665 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4724
Query: 723 KHTNYTMEHIRVGWEQLLTTIARTINEVENQIL 755
+ + +R W+ + N++E +L
Sbjct: 4725 LKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4757
Score = 38.5 bits (88), Expect = 0.029
Identities = 98/514 (19%), Positives = 204/514 (39%), Gaps = 76/514 (14%)
Query: 221 VTNLNNAFEVAEKYLDIP---KMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETA 277
V+N++ + AEK P + + +E+I +A+ T + A G + +
Sbjct: 1482 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI--QLFLAKHGDKMTDEE 1539
Query: 278 ANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRD 337
N + K + L E Y L S+ L+ ++ + + +V +K + E QQ+ ++
Sbjct: 1540 RNELEKQVKT------LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKE--- 1590
Query: 338 YRRVHKPPKVQEKCQLEINFNTLQTKLRL-SNRPAFMPSEGKM-VSDINNGWQHLEQAEK 395
K+Q C L QT+ RL ++ AFM +G + + + + L++ +
Sbjct: 1591 --------KLQGICDL-----LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQ 1637
Query: 396 GYEEWLLNEIRRLER-LDHLAEKFRQ--KASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
G + L ++ E L EK Q KA I + EA +K ++KA
Sbjct: 1638 GSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL---NEAKIKCEQL------NLKAE 1688
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
K E + A ++ E++AA+ Q T+ + + D W L++
Sbjct: 1689 QSKKELDKVVTTAIKEETEKVAAVKQ---------LEESKTKIENLLD-W-----LSNVD 1733
Query: 513 REALEKTEKQLEAIDQ--LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI-SA 569
+++ K + I+Q H + + ED + ++ T +++G + +
Sbjct: 1734 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGE------EDEVNGNLLET--DVDGQVGTT 1785
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
+ + E I++ H+ +S + L Y ++P+ + +++L
Sbjct: 1786 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY--LSPEEKEKLQKNMKEL 1843
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQ---FASQANVVGPWIQTKMEEIGRISI---EMNGTL 683
+ AL E + K + L+ + F + W+Q +E+ + ++NG L
Sbjct: 1844 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDING-L 1902
Query: 684 EDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEA 717
+L K + ++ +K +L + + EA
Sbjct: 1903 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1936
Score = 35.4 bits (80), Expect = 0.24
Identities = 70/357 (19%), Positives = 141/357 (39%), Gaps = 60/357 (16%)
Query: 209 LIEYDKLRKDDPVTNLNNAF-EVAEKYLDIPKMLDA-----EDIVNTARPDEKAIM---- 258
L E D KD VT L+ E ++L+ K L+ ++I + P +KA++
Sbjct: 2232 LTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKT 2289
Query: 259 TYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLED 318
+S + K + A C + ++ ++ L L WI+ T +
Sbjct: 2290 NNLSKKFKEMEDTIKEKKEAVTSC---------QEQLDAFQVLVKSLKSWIKETTKKVPI 2340
Query: 319 RVPQKTIQEMQQKLEDFRDYRRVH--KPPKVQE-------KCQLEINFNT---------- 359
P +++ + LED + + K P++Q+ C L T
Sbjct: 2341 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2400
Query: 360 ----LQTKLRLSNRPAFMPSEG-----KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLER 410
L + +N F ++G K ++DI++G++ L K L ++ +L
Sbjct: 2401 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL-- 2458
Query: 411 LDHLAEKFRQKASIHEAWTD--GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQD 468
+K ++++S W K A + +K + ++++FE++L + +
Sbjct: 2459 -----QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2513
Query: 469 RVEQIAAIAQELNE--LDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
+V+++ EL E D ++ +I +W L LT R++ LE++ L
Sbjct: 2514 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2570
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 243 bits (621), Expect = 5e-64
Identities = 141/382 (36%), Positives = 216/382 (56%), Gaps = 18/382 (4%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR H+
Sbjct: 74 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 132
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 133 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 192
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW Q+ T Y + +NF W+DG FNA+IH++RP+LI+ + + + NL
Sbjct: 193 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 252
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+AF VAEK + + ++LD ED V+ + PDEK+++TYVSS Y AF +
Sbjct: 253 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 303
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
+ N +E Y+ + + L++WIR + + +R E++ + ++ P
Sbjct: 304 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 362
Query: 345 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNE 404
PK EK +++ + L+ + +G +DI W L A E+ L E
Sbjct: 363 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 419
Query: 405 IRRLERLDHLAEKFRQKASIHE 426
+ RLE L +A + ++ + I E
Sbjct: 420 VERLEMLQQIANRVQRDSVICE 441
Score = 56.2 bits (134), Expect = 1e-07
Identities = 102/522 (19%), Positives = 209/522 (40%), Gaps = 65/522 (12%)
Query: 216 RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAE 275
++ + + + ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4150 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4209
Query: 276 TAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT-IQEMQQKLED 334
+RI K+ +E Y+ + +W+ L P T ++ ++Q++E+
Sbjct: 4210 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4263
Query: 335 FRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAE 394
+ ++ E Q +I L + L + S+ V D L+
Sbjct: 4264 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIW 4312
Query: 395 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIR 454
EE ++N +LE +F+ AW E +L + I+ +
Sbjct: 4313 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4372
Query: 455 KHEAFESDLAAHQDRVEQIAAIAQELNELDY-YDSHNVNTRCQKICDQWDALGSLTHSRR 513
KH ++D+ AHQ VE + +L E ++ N+ + + + +W +
Sbjct: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW----------Q 4422
Query: 514 EALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQF 573
LEKTE++ + +D ++A F+ +EDLQ + + E + A
Sbjct: 4423 NVLEKTEQRKQQLDGA----LRQAKGFHG----EIEDLQQW-----LTDTERHLLASKPL 4469
Query: 574 KSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKR 633
LP+ +E+ L +H E E+ + S +K QQ++ +
Sbjct: 4470 GG-LPETAKEQ---LNVHMEVCAAFEAKE--------------ETYKSLMQKGQQMLARC 4511
Query: 634 DHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQY 693
+ E + Q +L+ ++ S + +TK+EE +++E + +L+D ++ L Q
Sbjct: 4512 PKSA--ETNIDQDINNLKEKWESVETKLNER-KTKLEEALNLAMEFHNSLQDFINWLTQA 4568
Query: 694 ERSI-VDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRV 734
E+++ V +P+L +L+ I E +F N+ ++ + I +
Sbjct: 4569 EQTLNVASRPSL-ILDTVLFQIDEHKVFANEVNSHREQIIEL 4609
Score = 44.7 bits (104), Expect = 4e-04
Identities = 87/500 (17%), Positives = 207/500 (41%), Gaps = 53/500 (10%)
Query: 303 SDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRR-----------VHKPPKVQEKC 351
SD +WI + I ++ Q ++ + KL D + +++ + +K
Sbjct: 2679 SDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM 2736
Query: 352 QLEINFNTLQTKLR--LSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLE 409
+ EI Q K+ L + + E + ++++ + + ++ K E+ N ++ L+
Sbjct: 2737 KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQ 2796
Query: 410 RLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR 469
+ +F+Q + +AW D K+ +A L +++LI+ H+ F L A
Sbjct: 2797 SACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2856
Query: 470 VEQIAAIAQE-LNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQ 528
E+ A + L + + + + I WD ++ E+ K E++++
Sbjct: 2857 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NKQVKERENKLKESLEK 2910
Query: 529 LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAIL 588
L+Y ++ W++ +L+++ E E I+ + KS + D+ +
Sbjct: 2911 A-LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHFGMVE 2966
Query: 589 AIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNE 648
++ A + + +++ ++ + L+ K D + SK+ E
Sbjct: 2967 LLNNTANSLLS-----------VCEIDKEVVT---DENKSLIQKVDMVTEQLHSKKFCLE 3012
Query: 649 HLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQ------LSHLKQYERSIVDYKP 702
++ ++F V + + + ++++ +L Q L+ L+ ++S+ K
Sbjct: 3013 NMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3070
Query: 703 NLDLLEQQHQ-LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTR-DAK 760
+DL ++ Q L+ EA D+K T+ + + Q +T+++ ++E + + T+
Sbjct: 3071 QVDLAKRLAQDLVVEA--SDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQGI 3127
Query: 761 GISQEQMQEFRASFNHFDKD 780
G Q ++E + F FD +
Sbjct: 3128 GHFQNTIREMFSQFAEFDDE 3147
Score = 44.7 bits (104), Expect = 4e-04
Identities = 99/540 (18%), Positives = 211/540 (39%), Gaps = 88/540 (16%)
Query: 261 VSSFYHAFSGAQKAETAANRICKVLAVNQENEH----LMEDYEKLASDLLEWIRRTIPWL 316
+ +F + AN+ CK++ +E + D E L+ + + R
Sbjct: 3168 IKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQA-R 3226
Query: 317 EDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM--- 373
E++V + TI+ +++ +++ + + + E+ Q + T +L+ F
Sbjct: 3227 EEQV-EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3285
Query: 374 --PSEGKMVSDINNGWQHLEQAE------KGYEE--------WLLNEIRRLERLDHLAE- 416
P +GK D+N Q L Q+ +G E W + +R L E
Sbjct: 3286 IEPLQGKQ-QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3344
Query: 417 -----KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVE 471
+F+ +W E ++ ++ +A +KA I++ + + L + VE
Sbjct: 3345 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3404
Query: 472 QIAAIAQEL-NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLH 530
I +++ + D + + + +W+AL + +R +QLE I +
Sbjct: 3405 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVA 3457
Query: 531 LEYAKRAAPFNNWMESAMEDLQDMFIVHT-IEEIEGLISAHDQFKSTLPDADREREAILA 589
++ + P N W+ + + L + + T ++E I+ H + + + ++ ++
Sbjct: 3458 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3517
Query: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEK--VQQLVPKRDHALLEEQSKQQSN 647
I + ++++S+ +K VQ + +E Q K S
Sbjct: 3518 IGQSL----------------------KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR 3555
Query: 648 EHLRRQFASQANVVGP-------WIQTKMEEIGRISIEMNGT--LEDQLSHLKQYERSIV 698
L +Q A + G W+ +++ ++S++ T L Q S L+ + I+
Sbjct: 3556 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3615
Query: 699 DYKPNLD--LLEQQHQLIQ----EALIFDNKHTNYTMEHIRVGWE---QLLTTIARTINE 749
K N+D LL L Q E LI +K +E I+ ++ +L T +A+T+ +
Sbjct: 3616 LRKQNVDQALLNGLELLKQTTGDEVLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3670
Score = 43.5 bits (101), Expect = 9e-04
Identities = 65/334 (19%), Positives = 122/334 (36%), Gaps = 50/334 (14%)
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQ---EMQQKLEDFRDYR 339
KV+ E ++D K A E + + WLE+ +K++ E+ + +
Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4698
Query: 340 RVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGK---MVSDINNGWQHL----EQ 392
HK + + + T +T L + + K M+S++ + W + +
Sbjct: 4699 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4758
Query: 393 AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
+ EE LL + + L L + W E L + + L
Sbjct: 4759 RQNKLEEALLFSGQFTDALQALID-----------WLYRVEPQLAEDQPVHGDIDLVMNL 4807
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
I H+AF+ +L V+ + A+EL E DS V + Q++ +W+ + +L+ S+
Sbjct: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
Query: 513 REALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQ 572
+ LE +Q E E+ W+ A + L+
Sbjct: 4868 QTRLEAALRQAE-------EFHSVVHALLEWLAEAEQTLR-------------------- 4900
Query: 573 FKSTLPDADREREAILAIHKEAQRIAESNHIKLS 606
F LPD + ++ HKE + E +L+
Sbjct: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELN 4934
Score = 42.0 bits (97), Expect = 0.003
Identities = 49/273 (17%), Positives = 116/273 (42%), Gaps = 29/273 (10%)
Query: 490 NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAME 549
N++ + ++W+++ + + R+ LE EA++ L +E+ F NW+ A +
Sbjct: 4518 NIDQDINNLKEKWESVETKLNERKTKLE------EALN-LAMEFHNSLQDFINWLTQAEQ 4570
Query: 550 DLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSN 609
L I ++ ++ D+ K + + RE I+ + K H+K
Sbjct: 4571 TLNVASRPSLI--LDTVLFQIDEHKVFANEVNSHREQIIELDKTG------THLKYFSQK 4622
Query: 610 PYTTVTPQI---INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQ 666
+ + + S+WEKV Q + +R +L + + + +QF + + W++
Sbjct: 4623 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR-------AKQFHEAWSKLMEWLE 4675
Query: 667 TKMEEI-GRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE--ALIFDN 722
+ + + I + ++ QL+ K++++S+ D + + ++E +L DN
Sbjct: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4735
Query: 723 KHTNYTMEHIRVGWEQLLTTIARTINEVENQIL 755
+ + +R W+ + N++E +L
Sbjct: 4736 LKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4768
Score = 38.5 bits (88), Expect = 0.029
Identities = 98/514 (19%), Positives = 204/514 (39%), Gaps = 76/514 (14%)
Query: 221 VTNLNNAFEVAEKYLDIP---KMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETA 277
V+N++ + AEK P + + +E+I +A+ T + A G + +
Sbjct: 1493 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI--QLFLAKHGDKMTDEE 1550
Query: 278 ANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRD 337
N + K + L E Y L S+ L+ ++ + + +V +K + E QQ+ ++
Sbjct: 1551 RNELEKQVKT------LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKE--- 1601
Query: 338 YRRVHKPPKVQEKCQLEINFNTLQTKLRL-SNRPAFMPSEGKM-VSDINNGWQHLEQAEK 395
K+Q C L QT+ RL ++ AFM +G + + + + L++ +
Sbjct: 1602 --------KLQGICDL-----LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQ 1648
Query: 396 GYEEWLLNEIRRLER-LDHLAEKFRQ--KASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
G + L ++ E L EK Q KA I + EA +K ++KA
Sbjct: 1649 GSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL---NEAKIKCEQL------NLKAE 1699
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
K E + A ++ E++AA+ Q T+ + + D W L++
Sbjct: 1700 QSKKELDKVVTTAIKEETEKVAAVKQ---------LEESKTKIENLLD-W-----LSNVD 1744
Query: 513 REALEKTEKQLEAIDQ--LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI-SA 569
+++ K + I+Q H + + ED + ++ T +++G + +
Sbjct: 1745 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGE------EDEVNGNLLET--DVDGQVGTT 1796
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
+ + E I++ H+ +S + L Y ++P+ + +++L
Sbjct: 1797 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY--LSPEEKEKLQKNMKEL 1854
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQ---FASQANVVGPWIQTKMEEIGRISI---EMNGTL 683
+ AL E + K + L+ + F + W+Q +E+ + ++NG L
Sbjct: 1855 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDING-L 1913
Query: 684 EDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEA 717
+L K + ++ +K +L + + EA
Sbjct: 1914 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1947
Score = 35.4 bits (80), Expect = 0.24
Identities = 70/357 (19%), Positives = 141/357 (39%), Gaps = 60/357 (16%)
Query: 209 LIEYDKLRKDDPVTNLNNAF-EVAEKYLDIPKMLDA-----EDIVNTARPDEKAIM---- 258
L E D KD VT L+ E ++L+ K L+ ++I + P +KA++
Sbjct: 2243 LTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKT 2300
Query: 259 TYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLED 318
+S + K + A C + ++ ++ L L WI+ T +
Sbjct: 2301 NNLSKKFKEMEDTIKEKKEAVTSC---------QEQLDAFQVLVKSLKSWIKETTKKVPI 2351
Query: 319 RVPQKTIQEMQQKLEDFRDYRRVH--KPPKVQE-------KCQLEINFNT---------- 359
P +++ + LED + + K P++Q+ C L T
Sbjct: 2352 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2411
Query: 360 ----LQTKLRLSNRPAFMPSEG-----KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLER 410
L + +N F ++G K ++DI++G++ L K L ++ +L
Sbjct: 2412 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL-- 2469
Query: 411 LDHLAEKFRQKASIHEAWTD--GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQD 468
+K ++++S W K A + +K + ++++FE++L + +
Sbjct: 2470 -----QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2524
Query: 469 RVEQIAAIAQELNE--LDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
+V+++ EL E D ++ +I +W L LT R++ LE++ L
Sbjct: 2525 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2581
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 243 bits (621), Expect = 5e-64
Identities = 141/382 (36%), Positives = 216/382 (56%), Gaps = 18/382 (4%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR H+
Sbjct: 212 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 270
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 271 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 330
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW Q+ T Y + +NF W+DG FNA+IH++RP+LI+ + + + NL
Sbjct: 331 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 390
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+AF VAEK + + ++LD ED V+ + PDEK+++TYVSS Y AF +
Sbjct: 391 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 441
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
+ N +E Y+ + + L++WIR + + +R E++ + ++ P
Sbjct: 442 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 500
Query: 345 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNE 404
PK EK +++ + L+ + +G +DI W L A E+ L E
Sbjct: 501 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 557
Query: 405 IRRLERLDHLAEKFRQKASIHE 426
+ RLE L +A + ++ + I E
Sbjct: 558 VERLEMLQQIANRVQRDSVICE 579
Score = 56.2 bits (134), Expect = 1e-07
Identities = 102/522 (19%), Positives = 209/522 (40%), Gaps = 65/522 (12%)
Query: 216 RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAE 275
++ + + + ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4288 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4347
Query: 276 TAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT-IQEMQQKLED 334
+RI K+ +E Y+ + +W+ L P T ++ ++Q++E+
Sbjct: 4348 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4401
Query: 335 FRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAE 394
+ ++ E Q +I L + L + S+ V D L+
Sbjct: 4402 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIW 4450
Query: 395 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIR 454
EE ++N +LE +F+ AW E +L + I+ +
Sbjct: 4451 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4510
Query: 455 KHEAFESDLAAHQDRVEQIAAIAQELNELDY-YDSHNVNTRCQKICDQWDALGSLTHSRR 513
KH ++D+ AHQ VE + +L E ++ N+ + + + +W +
Sbjct: 4511 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW----------Q 4560
Query: 514 EALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQF 573
LEKTE++ + +D ++A F+ +EDLQ + + E + A
Sbjct: 4561 NVLEKTEQRKQQLDGA----LRQAKGFHG----EIEDLQQW-----LTDTERHLLASKPL 4607
Query: 574 KSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKR 633
LP+ +E+ L +H E E+ + S +K QQ++ +
Sbjct: 4608 GG-LPETAKEQ---LNVHMEVCAAFEAKE--------------ETYKSLMQKGQQMLARC 4649
Query: 634 DHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQY 693
+ E + Q +L+ ++ S + +TK+EE +++E + +L+D ++ L Q
Sbjct: 4650 PKSA--ETNIDQDINNLKEKWESVETKLNER-KTKLEEALNLAMEFHNSLQDFINWLTQA 4706
Query: 694 ERSI-VDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRV 734
E+++ V +P+L +L+ I E +F N+ ++ + I +
Sbjct: 4707 EQTLNVASRPSL-ILDTVLFQIDEHKVFANEVNSHREQIIEL 4747
Score = 44.7 bits (104), Expect = 4e-04
Identities = 87/500 (17%), Positives = 207/500 (41%), Gaps = 53/500 (10%)
Query: 303 SDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRR-----------VHKPPKVQEKC 351
SD +WI + I ++ Q ++ + KL D + +++ + +K
Sbjct: 2817 SDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM 2874
Query: 352 QLEINFNTLQTKLR--LSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLE 409
+ EI Q K+ L + + E + ++++ + + ++ K E+ N ++ L+
Sbjct: 2875 KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQ 2934
Query: 410 RLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR 469
+ +F+Q + +AW D K+ +A L +++LI+ H+ F L A
Sbjct: 2935 SACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2994
Query: 470 VEQIAAIAQE-LNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQ 528
E+ A + L + + + + I WD ++ E+ K E++++
Sbjct: 2995 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NKQVKERENKLKESLEK 3048
Query: 529 LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAIL 588
L+Y ++ W++ +L+++ E E I+ + KS + D+ +
Sbjct: 3049 A-LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHFGMVE 3104
Query: 589 AIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNE 648
++ A + + +++ ++ + L+ K D + SK+ E
Sbjct: 3105 LLNNTANSLLS-----------VCEIDKEVVT---DENKSLIQKVDMVTEQLHSKKFCLE 3150
Query: 649 HLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQ------LSHLKQYERSIVDYKP 702
++ ++F V + + + ++++ +L Q L+ L+ ++S+ K
Sbjct: 3151 NMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3208
Query: 703 NLDLLEQQHQ-LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTR-DAK 760
+DL ++ Q L+ EA D+K T+ + + Q +T+++ ++E + + T+
Sbjct: 3209 QVDLAKRLAQDLVVEA--SDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQGI 3265
Query: 761 GISQEQMQEFRASFNHFDKD 780
G Q ++E + F FD +
Sbjct: 3266 GHFQNTIREMFSQFAEFDDE 3285
Score = 44.7 bits (104), Expect = 4e-04
Identities = 99/540 (18%), Positives = 211/540 (39%), Gaps = 88/540 (16%)
Query: 261 VSSFYHAFSGAQKAETAANRICKVLAVNQENEH----LMEDYEKLASDLLEWIRRTIPWL 316
+ +F + AN+ CK++ +E + D E L+ + + R
Sbjct: 3306 IKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQA-R 3364
Query: 317 EDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM--- 373
E++V + TI+ +++ +++ + + + E+ Q + T +L+ F
Sbjct: 3365 EEQV-EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3423
Query: 374 --PSEGKMVSDINNGWQHLEQAE------KGYEE--------WLLNEIRRLERLDHLAE- 416
P +GK D+N Q L Q+ +G E W + +R L E
Sbjct: 3424 IEPLQGKQ-QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3482
Query: 417 -----KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVE 471
+F+ +W E ++ ++ +A +KA I++ + + L + VE
Sbjct: 3483 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3542
Query: 472 QIAAIAQEL-NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLH 530
I +++ + D + + + +W+AL + +R +QLE I +
Sbjct: 3543 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVA 3595
Query: 531 LEYAKRAAPFNNWMESAMEDLQDMFIVHT-IEEIEGLISAHDQFKSTLPDADREREAILA 589
++ + P N W+ + + L + + T ++E I+ H + + + ++ ++
Sbjct: 3596 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3655
Query: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEK--VQQLVPKRDHALLEEQSKQQSN 647
I + ++++S+ +K VQ + +E Q K S
Sbjct: 3656 IGQSL----------------------KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR 3693
Query: 648 EHLRRQFASQANVVGP-------WIQTKMEEIGRISIEMNGT--LEDQLSHLKQYERSIV 698
L +Q A + G W+ +++ ++S++ T L Q S L+ + I+
Sbjct: 3694 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3753
Query: 699 DYKPNLD--LLEQQHQLIQ----EALIFDNKHTNYTMEHIRVGWE---QLLTTIARTINE 749
K N+D LL L Q E LI +K +E I+ ++ +L T +A+T+ +
Sbjct: 3754 LRKQNVDQALLNGLELLKQTTGDEVLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3808
Score = 43.5 bits (101), Expect = 9e-04
Identities = 65/334 (19%), Positives = 122/334 (36%), Gaps = 50/334 (14%)
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQ---EMQQKLEDFRDYR 339
KV+ E ++D K A E + + WLE+ +K++ E+ + +
Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4836
Query: 340 RVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGK---MVSDINNGWQHL----EQ 392
HK + + + T +T L + + K M+S++ + W + +
Sbjct: 4837 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4896
Query: 393 AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
+ EE LL + + L L + W E L + + L
Sbjct: 4897 RQNKLEEALLFSGQFTDALQALID-----------WLYRVEPQLAEDQPVHGDIDLVMNL 4945
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
I H+AF+ +L V+ + A+EL E DS V + Q++ +W+ + +L+ S+
Sbjct: 4946 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 5005
Query: 513 REALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQ 572
+ LE +Q E E+ W+ A + L+
Sbjct: 5006 QTRLEAALRQAE-------EFHSVVHALLEWLAEAEQTLR-------------------- 5038
Query: 573 FKSTLPDADREREAILAIHKEAQRIAESNHIKLS 606
F LPD + ++ HKE + E +L+
Sbjct: 5039 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELN 5072
Score = 42.0 bits (97), Expect = 0.003
Identities = 49/273 (17%), Positives = 116/273 (42%), Gaps = 29/273 (10%)
Query: 490 NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAME 549
N++ + ++W+++ + + R+ LE EA++ L +E+ F NW+ A +
Sbjct: 4656 NIDQDINNLKEKWESVETKLNERKTKLE------EALN-LAMEFHNSLQDFINWLTQAEQ 4708
Query: 550 DLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSN 609
L I ++ ++ D+ K + + RE I+ + K H+K
Sbjct: 4709 TLNVASRPSLI--LDTVLFQIDEHKVFANEVNSHREQIIELDKTG------THLKYFSQK 4760
Query: 610 PYTTVTPQI---INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQ 666
+ + + S+WEKV Q + +R +L + + + +QF + + W++
Sbjct: 4761 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR-------AKQFHEAWSKLMEWLE 4813
Query: 667 TKMEEI-GRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE--ALIFDN 722
+ + + I + ++ QL+ K++++S+ D + + ++E +L DN
Sbjct: 4814 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4873
Query: 723 KHTNYTMEHIRVGWEQLLTTIARTINEVENQIL 755
+ + +R W+ + N++E +L
Sbjct: 4874 LKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4906
Score = 38.5 bits (88), Expect = 0.029
Identities = 98/514 (19%), Positives = 204/514 (39%), Gaps = 76/514 (14%)
Query: 221 VTNLNNAFEVAEKYLDIP---KMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETA 277
V+N++ + AEK P + + +E+I +A+ T + A G + +
Sbjct: 1631 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI--QLFLAKHGDKMTDEE 1688
Query: 278 ANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRD 337
N + K + L E Y L S+ L+ ++ + + +V +K + E QQ+ ++
Sbjct: 1689 RNELEKQVKT------LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKE--- 1739
Query: 338 YRRVHKPPKVQEKCQLEINFNTLQTKLRL-SNRPAFMPSEGKM-VSDINNGWQHLEQAEK 395
K+Q C L QT+ RL ++ AFM +G + + + + L++ +
Sbjct: 1740 --------KLQGICDL-----LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQ 1786
Query: 396 GYEEWLLNEIRRLER-LDHLAEKFRQ--KASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
G + L ++ E L EK Q KA I + EA +K ++KA
Sbjct: 1787 GSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL---NEAKIKCEQL------NLKAE 1837
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
K E + A ++ E++AA+ Q T+ + + D W L++
Sbjct: 1838 QSKKELDKVVTTAIKEETEKVAAVKQ---------LEESKTKIENLLD-W-----LSNVD 1882
Query: 513 REALEKTEKQLEAIDQ--LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI-SA 569
+++ K + I+Q H + + ED + ++ T +++G + +
Sbjct: 1883 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGE------EDEVNGNLLET--DVDGQVGTT 1934
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
+ + E I++ H+ +S + L Y ++P+ + +++L
Sbjct: 1935 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY--LSPEEKEKLQKNMKEL 1992
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQ---FASQANVVGPWIQTKMEEIGRISI---EMNGTL 683
+ AL E + K + L+ + F + W+Q +E+ + ++NG L
Sbjct: 1993 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDING-L 2051
Query: 684 EDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEA 717
+L K + ++ +K +L + + EA
Sbjct: 2052 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 2085
Score = 35.4 bits (80), Expect = 0.24
Identities = 70/357 (19%), Positives = 141/357 (39%), Gaps = 60/357 (16%)
Query: 209 LIEYDKLRKDDPVTNLNNAF-EVAEKYLDIPKMLDA-----EDIVNTARPDEKAIM---- 258
L E D KD VT L+ E ++L+ K L+ ++I + P +KA++
Sbjct: 2381 LTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKT 2438
Query: 259 TYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLED 318
+S + K + A C + ++ ++ L L WI+ T +
Sbjct: 2439 NNLSKKFKEMEDTIKEKKEAVTSC---------QEQLDAFQVLVKSLKSWIKETTKKVPI 2489
Query: 319 RVPQKTIQEMQQKLEDFRDYRRVH--KPPKVQE-------KCQLEINFNT---------- 359
P +++ + LED + + K P++Q+ C L T
Sbjct: 2490 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2549
Query: 360 ----LQTKLRLSNRPAFMPSEG-----KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLER 410
L + +N F ++G K ++DI++G++ L K L ++ +L
Sbjct: 2550 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL-- 2607
Query: 411 LDHLAEKFRQKASIHEAWTD--GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQD 468
+K ++++S W K A + +K + ++++FE++L + +
Sbjct: 2608 -----QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2662
Query: 469 RVEQIAAIAQELNE--LDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
+V+++ EL E D ++ +I +W L LT R++ LE++ L
Sbjct: 2663 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2719
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 243 bits (621), Expect = 5e-64
Identities = 141/382 (36%), Positives = 216/382 (56%), Gaps = 18/382 (4%)
Query: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
+K Q+KTFT W N HL K + ++ ED RDG L+ LLEV+SG+ LP+ E+G+MR H+
Sbjct: 34 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 92
Query: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV----EETS 164
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 93 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 152
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
AKE LLLW Q+ T Y + +NF W+DG FNA+IH++RP+LI+ + + + NL
Sbjct: 153 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 212
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+AF VAEK + + ++LD ED V+ + PDEK+++TYVSS Y AF +
Sbjct: 213 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 263
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKP 344
+ N +E Y+ + + L++WIR + + +R E++ + ++ P
Sbjct: 264 IGANDVEVKWIE-YQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 322
Query: 345 PKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNE 404
PK EK +++ + L+ + +G +DI W L A E+ L E
Sbjct: 323 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 379
Query: 405 IRRLERLDHLAEKFRQKASIHE 426
+ RLE L +A + ++ + I E
Sbjct: 380 VERLEMLQQIANRVQRDSVICE 401
Score = 56.2 bits (134), Expect = 1e-07
Identities = 102/522 (19%), Positives = 209/522 (40%), Gaps = 65/522 (12%)
Query: 216 RKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAE 275
++ + + + ++ LDI L +E I PD+ + + A+ KA
Sbjct: 4110 QQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWDSLNKAW 4169
Query: 276 TAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKT-IQEMQQKLED 334
+RI K+ +E Y+ + +W+ L P T ++ ++Q++E+
Sbjct: 4170 K--DRIDKL----EEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEE 4223
Query: 335 FRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAE 394
+ ++ E Q +I L + L + S+ V D L+
Sbjct: 4224 LKQFK--------SEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQD---PLMELKLIW 4272
Query: 395 KGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIR 454
EE ++N +LE +F+ AW E +L + I+ +
Sbjct: 4273 DSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELA 4332
Query: 455 KHEAFESDLAAHQDRVEQIAAIAQELNELDY-YDSHNVNTRCQKICDQWDALGSLTHSRR 513
KH ++D+ AHQ VE + +L E ++ N+ + + + +W +
Sbjct: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRW----------Q 4382
Query: 514 EALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQF 573
LEKTE++ + +D ++A F+ +EDLQ + + E + A
Sbjct: 4383 NVLEKTEQRKQQLDGA----LRQAKGFHG----EIEDLQQW-----LTDTERHLLASKPL 4429
Query: 574 KSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKR 633
LP+ +E+ L +H E E+ + S +K QQ++ +
Sbjct: 4430 GG-LPETAKEQ---LNVHMEVCAAFEAKE--------------ETYKSLMQKGQQMLARC 4471
Query: 634 DHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQY 693
+ E + Q +L+ ++ S + +TK+EE +++E + +L+D ++ L Q
Sbjct: 4472 PKSA--ETNIDQDINNLKEKWESVETKLNER-KTKLEEALNLAMEFHNSLQDFINWLTQA 4528
Query: 694 ERSI-VDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRV 734
E+++ V +P+L +L+ I E +F N+ ++ + I +
Sbjct: 4529 EQTLNVASRPSL-ILDTVLFQIDEHKVFANEVNSHREQIIEL 4569
Score = 44.7 bits (104), Expect = 4e-04
Identities = 87/500 (17%), Positives = 207/500 (41%), Gaps = 53/500 (10%)
Query: 303 SDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRR-----------VHKPPKVQEKC 351
SD +WI + I ++ Q ++ + KL D + +++ + +K
Sbjct: 2639 SDRCDWIDQAI--VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKM 2696
Query: 352 QLEINFNTLQTKLR--LSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLE 409
+ EI Q K+ L + + E + ++++ + + ++ K E+ N ++ L+
Sbjct: 2697 KQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQ 2756
Query: 410 RLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDR 469
+ +F+Q + +AW D K+ +A L +++LI+ H+ F L A
Sbjct: 2757 SACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHM 2816
Query: 470 VEQIAAIAQE-LNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQ 528
E+ A + L + + + + I WD ++ E+ K E++++
Sbjct: 2817 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTF------NKQVKERENKLKESLEK 2870
Query: 529 LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAIL 588
L+Y ++ W++ +L+++ E E I+ + KS + D+ +
Sbjct: 2871 A-LKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHFGMVE 2926
Query: 589 AIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNE 648
++ A + + +++ ++ + L+ K D + SK+ E
Sbjct: 2927 LLNNTANSLLS-----------VCEIDKEVVT---DENKSLIQKVDMVTEQLHSKKFCLE 2972
Query: 649 HLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQ------LSHLKQYERSIVDYKP 702
++ ++F V + + + ++++ +L Q L+ L+ ++S+ K
Sbjct: 2973 NMTQKFKEFQEVSKE--SKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKH 3030
Query: 703 NLDLLEQQHQ-LIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTR-DAK 760
+DL ++ Q L+ EA D+K T+ + + Q +T+++ ++E + + T+
Sbjct: 3031 QVDLAKRLAQDLVVEA--SDSKGTSDVLLQVET-IAQEHSTLSQQVDEKCSFLETKLQGI 3087
Query: 761 GISQEQMQEFRASFNHFDKD 780
G Q ++E + F FD +
Sbjct: 3088 GHFQNTIREMFSQFAEFDDE 3107
Score = 44.7 bits (104), Expect = 4e-04
Identities = 99/540 (18%), Positives = 211/540 (39%), Gaps = 88/540 (16%)
Query: 261 VSSFYHAFSGAQKAETAANRICKVLAVNQENEH----LMEDYEKLASDLLEWIRRTIPWL 316
+ +F + AN+ CK++ +E + D E L+ + + R
Sbjct: 3128 IKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQA-R 3186
Query: 317 EDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM--- 373
E++V + TI+ +++ +++ + + + E+ Q + T +L+ F
Sbjct: 3187 EEQV-EGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEE 3245
Query: 374 --PSEGKMVSDINNGWQHLEQAE------KGYEE--------WLLNEIRRLERLDHLAE- 416
P +GK D+N Q L Q+ +G E W + +R L E
Sbjct: 3246 IEPLQGKQ-QDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEA 3304
Query: 417 -----KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVE 471
+F+ +W E ++ ++ +A +KA I++ + + L + VE
Sbjct: 3305 LLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVE 3364
Query: 472 QIAAIAQEL-NELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLH 530
I +++ + D + + + +W+AL + +R +QLE I +
Sbjct: 3365 VIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVA 3417
Query: 531 LEYAKRAAPFNNWMESAMEDLQDMFIVHT-IEEIEGLISAHDQFKSTLPDADREREAILA 589
++ + P N W+ + + L + + T ++E I+ H + + + ++ ++
Sbjct: 3418 QQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS 3477
Query: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEK--VQQLVPKRDHALLEEQSKQQSN 647
I + ++++S+ +K VQ + +E Q K S
Sbjct: 3478 IGQSL----------------------KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSR 3515
Query: 648 EHLRRQFASQANVVGP-------WIQTKMEEIGRISIEMNGT--LEDQLSHLKQYERSIV 698
L +Q A + G W+ +++ ++S++ T L Q S L+ + I+
Sbjct: 3516 SELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDIL 3575
Query: 699 DYKPNLD--LLEQQHQLIQ----EALIFDNKHTNYTMEHIRVGWE---QLLTTIARTINE 749
K N+D LL L Q E LI +K +E I+ ++ +L T +A+T+ +
Sbjct: 3576 LRKQNVDQALLNGLELLKQTTGDEVLIIQDK-----LEAIKARYKDITKLSTDVAKTLEQ 3630
Score = 43.5 bits (101), Expect = 9e-04
Identities = 65/334 (19%), Positives = 122/334 (36%), Gaps = 50/334 (14%)
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQ---EMQQKLEDFRDYR 339
KV+ E ++D K A E + + WLE+ +K++ E+ + +
Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEES--EKSLDSELEIANDPDKIKTQL 4658
Query: 340 RVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGK---MVSDINNGWQHL----EQ 392
HK + + + T +T L + + K M+S++ + W + +
Sbjct: 4659 AQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVE 4718
Query: 393 AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
+ EE LL + + L L + W E L + + L
Sbjct: 4719 RQNKLEEALLFSGQFTDALQALID-----------WLYRVEPQLAEDQPVHGDIDLVMNL 4767
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
I H+AF+ +L V+ + A+EL E DS V + Q++ +W+ + +L+ S+
Sbjct: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
Query: 513 REALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQ 572
+ LE +Q E E+ W+ A + L+
Sbjct: 4828 QTRLEAALRQAE-------EFHSVVHALLEWLAEAEQTLR-------------------- 4860
Query: 573 FKSTLPDADREREAILAIHKEAQRIAESNHIKLS 606
F LPD + ++ HKE + E +L+
Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELN 4894
Score = 42.0 bits (97), Expect = 0.003
Identities = 49/273 (17%), Positives = 116/273 (42%), Gaps = 29/273 (10%)
Query: 490 NVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAME 549
N++ + ++W+++ + + R+ LE EA++ L +E+ F NW+ A +
Sbjct: 4478 NIDQDINNLKEKWESVETKLNERKTKLE------EALN-LAMEFHNSLQDFINWLTQAEQ 4530
Query: 550 DLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSN 609
L I ++ ++ D+ K + + RE I+ + K H+K
Sbjct: 4531 TLNVASRPSLI--LDTVLFQIDEHKVFANEVNSHREQIIELDKTG------THLKYFSQK 4582
Query: 610 PYTTVTPQI---INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQ 666
+ + + S+WEKV Q + +R +L + + + +QF + + W++
Sbjct: 4583 QDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR-------AKQFHEAWSKLMEWLE 4635
Query: 667 TKMEEI-GRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE--ALIFDN 722
+ + + I + ++ QL+ K++++S+ D + + ++E +L DN
Sbjct: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDN 4695
Query: 723 KHTNYTMEHIRVGWEQLLTTIARTINEVENQIL 755
+ + +R W+ + N++E +L
Sbjct: 4696 LKLDDMLSELRDKWDTICGKSVERQNKLEEALL 4728
Score = 38.5 bits (88), Expect = 0.029
Identities = 98/514 (19%), Positives = 204/514 (39%), Gaps = 76/514 (14%)
Query: 221 VTNLNNAFEVAEKYLDIP---KMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETA 277
V+N++ + AEK P + + +E+I +A+ T + A G + +
Sbjct: 1453 VSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQTI--QLFLAKHGDKMTDEE 1510
Query: 278 ANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRD 337
N + K + L E Y L S+ L+ ++ + + +V +K + E QQ+ ++
Sbjct: 1511 RNELEKQVKT------LQESYNLLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKE--- 1561
Query: 338 YRRVHKPPKVQEKCQLEINFNTLQTKLRL-SNRPAFMPSEGKM-VSDINNGWQHLEQAEK 395
K+Q C L QT+ RL ++ AFM +G + + + + L++ +
Sbjct: 1562 --------KLQGICDL-----LTQTENRLIGHQEAFMIGDGTVELKKYQSKQEELQKDMQ 1608
Query: 396 GYEEWLLNEIRRLER-LDHLAEKFRQ--KASIHEAWTDGKEAMLKHRDYETATLSDIKAL 452
G + L ++ E L EK Q KA I + EA +K ++KA
Sbjct: 1609 GSAQALAEVVKNTENFLKENGEKLSQEDKALIEQKL---NEAKIKCEQL------NLKAE 1659
Query: 453 IRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSR 512
K E + A ++ E++AA+ Q T+ + + D W L++
Sbjct: 1660 QSKKELDKVVTTAIKEETEKVAAVKQ---------LEESKTKIENLLD-W-----LSNVD 1704
Query: 513 REALEKTEKQLEAIDQ--LHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI-SA 569
+++ K + I+Q H + + ED + ++ T +++G + +
Sbjct: 1705 KDSERAGTKHKQVIEQNGTHFQEGDGKSAIGE------EDEVNGNLLET--DVDGQVGTT 1756
Query: 570 HDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQL 629
+ + E I++ H+ +S + L Y ++P+ + +++L
Sbjct: 1757 QENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQY--LSPEEKEKLQKNMKEL 1814
Query: 630 VPKRDHALLEEQSKQQSNEHLRRQ---FASQANVVGPWIQTKMEEIGRISI---EMNGTL 683
+ AL E + K + L+ + F + W+Q +E+ + ++NG L
Sbjct: 1815 KVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDING-L 1873
Query: 684 EDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEA 717
+L K + ++ +K +L + + EA
Sbjct: 1874 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEA 1907
Score = 35.4 bits (80), Expect = 0.24
Identities = 70/357 (19%), Positives = 141/357 (39%), Gaps = 60/357 (16%)
Query: 209 LIEYDKLRKDDPVTNLNNAF-EVAEKYLDIPKMLDA-----EDIVNTARPDEKAIM---- 258
L E D KD VT L+ E ++L+ K L+ ++I + P +KA++
Sbjct: 2203 LTEVDVPGKD--VTELSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKT 2260
Query: 259 TYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLED 318
+S + K + A C + ++ ++ L L WI+ T +
Sbjct: 2261 NNLSKKFKEMEDTIKEKKEAVTSC---------QEQLDAFQVLVKSLKSWIKETTKKVPI 2311
Query: 319 RVPQKTIQEMQQKLEDFRDYRRVH--KPPKVQE-------KCQLEINFNT---------- 359
P +++ + LED + + K P++Q+ C L T
Sbjct: 2312 VQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKS 2371
Query: 360 ----LQTKLRLSNRPAFMPSEG-----KMVSDINNGWQHLEQAEKGYEEWLLNEIRRLER 410
L + +N F ++G K ++DI++G++ L K L ++ +L
Sbjct: 2372 GGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKL-- 2429
Query: 411 LDHLAEKFRQKASIHEAWTD--GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQD 468
+K ++++S W K A + +K + ++++FE++L + +
Sbjct: 2430 -----QKAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVN 2484
Query: 469 RVEQIAAIAQELNE--LDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
+V+++ EL E D ++ +I +W L LT R++ LE++ L
Sbjct: 2485 KVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNL 2541
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 233 bits (595), Expect = 5e-61
Identities = 143/397 (36%), Positives = 215/397 (54%), Gaps = 28/397 (7%)
Query: 40 RDLLLDPAW----------EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLE 89
+D +LDPA ++ Q+KTFT W N HL K I ++ ED RDG L+ LLE
Sbjct: 58 QDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLE 117
Query: 90 VISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTI 149
V+SG +LP+ E+G+MR H++ NV ALDF+ + VKLV+I ++I DGN K+TLG+IWTI
Sbjct: 118 VLSGIKLPR-EKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTI 176
Query: 150 ILRFAIQDISVE----ETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRH 205
IL F I DI + + SAKE LLLW Q+ TA Y + NF W DG FNALIHR+
Sbjct: 177 ILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRY 236
Query: 206 RPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFY 265
RP+L++ ++++ NL AFEVAE+ L + ++LDAED V+ PDEK+++TYVSS Y
Sbjct: 237 RPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAED-VDVPSPDEKSVITYVSSIY 294
Query: 266 HAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTI 325
AF + + E + ++Y+ L+ WI++ + D+ +
Sbjct: 295 DAFPKVPEGGEGISA--------TEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNP 346
Query: 326 QEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINN 385
E++ + ++ K +EK ++E + L+ + +G +D+
Sbjct: 347 VELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGR---IKLPQGYHPNDVEE 403
Query: 386 GWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKA 422
W L E+ L + RLE L +A K + A
Sbjct: 404 EWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGA 440
Score = 50.8 bits (120), Expect = 6e-06
Identities = 88/504 (17%), Positives = 203/504 (40%), Gaps = 50/504 (9%)
Query: 298 YEKLASDLLEWIRRTIPWLEDRVPQKTIQE-MQQKLEDFRDYRRVHKPPKVQEKCQLEIN 356
Y++L DL E +R L + T E ++Q+LE+ + R + QL+
Sbjct: 2626 YQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIR--------SDLEQLDHE 2677
Query: 357 FNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAE 416
QT L + + + E + ++ + + +G E+ + I RL+ +
Sbjct: 2678 VKEAQT---LCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQ 2734
Query: 417 KFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAI 476
+F+Q W D K++ +A L +++ ++++E F+ L H E I A
Sbjct: 2735 QFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAE 2794
Query: 477 AQE--LNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYA 534
+ L+ + + + ++ + W+ L T R+ L+ ++ + Q H+E
Sbjct: 2795 GESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY-QWHVE-- 2851
Query: 535 KRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA 594
W+E + ++ + T++ ++ L S+ + K+ L + ++ R + ++ A
Sbjct: 2852 ----DLVPWIEDCKAKMSELRV--TLDPVQ-LESSLLRSKAMLNEVEKRRSLLEILNSAA 2904
Query: 595 QRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQF 654
+ S+ G Q +++ E++Q + + Q+S +++ ++
Sbjct: 2905 DILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKV 2964
Query: 655 ASQANVV-------GPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPN---- 703
+ + K E R E+ LE Q+ +L+ + + +V+ P+
Sbjct: 2965 EGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDA 3024
Query: 704 -----------LDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVEN 752
+ LE + ++ ++ +NK H RV ++ + +A +E++
Sbjct: 3025 SQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRV--REMFSQLADLDDELDG 3082
Query: 753 Q-ILTRDAKGISQEQMQEFRASFN 775
+ RD + Q Q+++ R N
Sbjct: 3083 MGAIGRDTDSL-QSQIEDVRLFLN 3105
Score = 50.4 bits (119), Expect = 7e-06
Identities = 108/539 (20%), Positives = 216/539 (40%), Gaps = 77/539 (14%)
Query: 272 QKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLED------RVPQKTI 325
+K E+ + + +N E +E + L + E PW+E+ ++P I
Sbjct: 3794 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI 3853
Query: 326 --QEMQQKLEDFRDYRR--VHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVS 381
++++Q+ E+ R R P + + ++ L P EG+MV
Sbjct: 3854 DHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELN------------PEEGEMVE 3901
Query: 382 DINNGWQHLEQAEKGYEEWLLNEIR-RLERLDHLAEKFRQKASIHE------AWTDGKEA 434
+ ++AE Y + + E+R R LD + Q H+ + +
Sbjct: 3902 ------EKYQKAENMYAQ-IKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSS 3954
Query: 435 MLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTR 494
L+ A + I+ I +++ +L Q E + +EL + + +
Sbjct: 3955 RLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL--IGRSQGADKDLA 4012
Query: 495 CQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESA-----ME 549
++I D+ D + + E E++++ +D L L A F W + A ++
Sbjct: 4013 AKEIQDKLDQMVFFWEDIKARAE--EREIKFLDVLEL-----AEKF--WYDMAALLTTIK 4063
Query: 550 DLQDMFIVHTIEE--IEGLISAHDQFKSTLPDADREREAILAIHKEAQ--RIAESNHIKL 605
D QD IVH +E I+ I K + A+ +E +H+E + RI ++ I
Sbjct: 4064 DTQD--IVHDLESPGIDPSI-----IKQQVEAAETIKEETDGLHEELEFIRILGADLIFA 4116
Query: 606 SGSNPYTTVTPQI--INSKWEKVQQLVPKRDHALLEE-QSKQQSNEHLRRQFASQANVVG 662
G V I +N+ WE + + +R L + Q+ Q + L+ F N V
Sbjct: 4117 CGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV- 4175
Query: 663 PWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALI--F 720
K+ + + ++N T++DQL+ +K+++ + + ++ L Q +L+ +
Sbjct: 4176 ----IKLCTMPPVGTDLN-TVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230
Query: 721 DNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDK 779
D + ++ WE L IA +++E +L A G Q ++E + H ++
Sbjct: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL---ALGQFQHALEELMSWLTHTEE 4286
Score = 48.1 bits (113), Expect = 4e-05
Identities = 67/341 (19%), Positives = 128/341 (37%), Gaps = 60/341 (17%)
Query: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRV- 341
KV+ + E ++D K A E ++ I WLED + +LE D ++
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAE-----SHLDSELEISNDPDKIK 4630
Query: 342 -----HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKM---VSDINNGW-----Q 388
HK + + + T++T L + K+ + ++ + W +
Sbjct: 4631 LQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGK 4690
Query: 389 HLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSD 448
+E+ K EE LL + ++ L L + W E L L
Sbjct: 4691 SVERQHK-LEEALLFSGQFMDALQALVD-----------WLYKVEPQLAEDQPVHGDLDL 4738
Query: 449 IKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSL 508
+ L+ H+ F+ +L V+ + +EL E D+ V + Q++ +WD + L
Sbjct: 4739 VMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKL 4798
Query: 509 THSRREALEKTEKQLEAI-DQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLI 567
+ S++ LE+ KQ E D +H+ W+ A + L+
Sbjct: 4799 SVSKQSRLEQALKQAEVFRDTVHM--------LLEWLSEAEQTLR--------------- 4835
Query: 568 SAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGS 608
F+ LPD ++++ HKE + E + ++ +
Sbjct: 4836 -----FRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSA 4871
Score = 47.4 bits (111), Expect = 6e-05
Identities = 78/443 (17%), Positives = 170/443 (38%), Gaps = 86/443 (19%)
Query: 298 YEKLASDLLEWIRRTIPWLEDRVPQ----KTIQEMQQKLEDFRD--YRRVHKPPKVQEKC 351
Y+ + +W+ T+ L P T+++ ++++F+ Y++ + K+ +
Sbjct: 4160 YQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG 4219
Query: 352 QLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERL 411
+L + T +T + P ++++ + W++L + + L + L +
Sbjct: 4220 ELMLKKATDETDRDIIREP---------LTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270
Query: 412 DHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVE 471
H E+ +W E +L + + I+ + KH ++D+ AHQ VE
Sbjct: 4271 QHALEELM-------SWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVE 4323
Query: 472 QIAAIAQELNELDY-YDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEA----I 526
+ EL E D+ ++ +R + + W+++ T R + L+ T +Q + I
Sbjct: 4324 TVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEI 4383
Query: 527 DQLHLEYAK------RAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDA 580
+ LE + + P E+A E L T E+ + A ++ + L D
Sbjct: 4384 EDFLLELTRMESQLSASKPTGGLPETAREQLD------THMELYSQLKAKEETYNQLLDK 4437
Query: 581 DREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEE 640
R ++ + ++ SGS T + ++ KW V + +R
Sbjct: 4438 GR----LMLLSRDD-----------SGSGSKTEQSVALLEQKWHVVSSKMEER------- 4475
Query: 641 QSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDY 700
++K+EE ++ E +L++ ++ L E+S+
Sbjct: 4476 -------------------------KSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIA 4510
Query: 701 KPNLDLLEQQHQLIQEALIFDNK 723
P +L I+E +F N+
Sbjct: 4511 SPPSLILNTVLSQIEEHKVFANE 4533
Score = 43.9 bits (102), Expect = 7e-04
Identities = 49/220 (22%), Positives = 97/220 (44%), Gaps = 27/220 (12%)
Query: 501 QWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTI 560
+++ LG + H R+E+L+ ++E E K A W+ES E L+ M + +
Sbjct: 2378 KYEKLGGVLHERQESLQAILNRME-------EVHKEANSVLQWLESKEEVLKSMDAMSSP 2430
Query: 561 EEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIIN 620
+ E + + + K+ L + ++ I + KEA + + + + ++ N
Sbjct: 2431 TKTETVKAQAESNKAFLAELEQNSPKIQKV-KEALAGLLVTYPNSQEAENWKKIQEEL-N 2488
Query: 621 SKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTK---MEEIGRISI 677
S+WE+ ++ R L ++S HL F + + + PW+ K M +G +SI
Sbjct: 2489 SRWERATEVTVARQRQL------EESASHL-ACFQAAESQLRPWLMEKELMMGVLGPLSI 2541
Query: 678 EMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEA 717
+ N L+ KQ + ++ + QQH+ + EA
Sbjct: 2542 DPN-----MLNAQKQQVQFML---KEFEARRQQHEQLNEA 2573
Score = 38.1 bits (87), Expect = 0.038
Identities = 80/450 (17%), Positives = 184/450 (40%), Gaps = 35/450 (7%)
Query: 267 AFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQ 326
A + A + ET ++ K LA N++ + D+ + +P +E Q +
Sbjct: 1660 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME----QLSGA 1715
Query: 327 EMQQKLEDFRD-YRRVHKPP-KVQEKCQL------EINFNTLQTKLRLSNRPAFMPSEGK 378
+++ D D Y V++ P K+ ++C++ E+ L + AF+ G
Sbjct: 1716 SLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGH 1775
Query: 379 MVSDINNGW--QHLEQAEKGYEEWLLN---EIRRLERLDHLAEKFRQKASIHEAWTDGKE 433
++ Q L + ++ Y L E+++++ L +KF Q E+W + E
Sbjct: 1776 NLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSE 1835
Query: 434 AMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELD------YYD 487
L++ ++ + +L+++ +F D+ +H+ + + Q++ +++
Sbjct: 1836 KELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEP 1895
Query: 488 SHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESA 547
S N K+ D + +L HS+ L L + Q H ++ A WM++
Sbjct: 1896 SEIGNLVKDKLKDATERYTAL-HSKCTRLGSHLNML--LGQYH-QFQNSADSLQAWMQAC 1951
Query: 548 MEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREA-ILAIHKEAQRIAESNHIKLS 606
+++ + + T+ G++ L + E + + + K A+ I E + +
Sbjct: 1952 EANVEKL-LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEG-EPA 2009
Query: 607 GSNPYTTVTPQIINSKWEKVQQLVPKR----DHALLEEQSKQQSNEHLRRQFAS-QANVV 661
+ + T I S ++ + + +R A+ + QS Q+S E L + + N+
Sbjct: 2010 PDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLE 2069
Query: 662 GPWIQTKMEEIGRISIEMNGTLEDQLSHLK 691
G + + + + ++ N L+ ++ K
Sbjct: 2070 GKQVSSLSSGVIQEALATNMKLKQDIARQK 2099
Score = 37.4 bits (85), Expect = 0.064
Identities = 53/225 (23%), Positives = 92/225 (40%), Gaps = 23/225 (10%)
Query: 277 AANRICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVP-----QKTIQEMQQK 331
+A + C V Q EH ME+ + L + + + I L++ + Q ++ +
Sbjct: 3237 SAGKDCDV----QGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSW 3292
Query: 332 LEDFRDYRRVHKPPKVQEKC-QLEINFNTLQTKLRLSNRPA---FMPSEGKMVS------ 381
L D + KPP + K + +I L +L L +R A + +EG ++
Sbjct: 3293 LADTEELIANQKPPSAEYKVVKAQIQEQKLLQRL-LDDRKATVDMLQAEGGRIAQSAELA 3351
Query: 382 DINNGWQHLEQAEKGYEEWLLNEIRRLERLDH---LAEKFRQKASIHEAWTDGKEAMLKH 438
D LE E + E L R ++L+ LA++F + A + E L +
Sbjct: 3352 DREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLAN 3411
Query: 439 RDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNEL 483
+ + I+ I +H+A E D+ H V Q I Q L+ L
Sbjct: 3412 SEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSL 3456
Score = 35.4 bits (80), Expect = 0.24
Identities = 65/298 (21%), Positives = 125/298 (41%), Gaps = 44/298 (14%)
Query: 202 IHRHRPELIEYDKLRKD-DPVTNLNNAFEVAEKYLD----IPKML--DAEDIVNTARPDE 254
+++ P+L E + D D V NL +A +V +K L ++L +++ +R D
Sbjct: 4719 LYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDT 4778
Query: 255 KAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQEN-EHLMEDYEKLASD---LLEWIR 310
T+V Q+ T + +CK+ Q E ++ E LLEW+
Sbjct: 4779 ----TWVKG------QLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVHMLLEWLS 4828
Query: 311 RTIPWLEDR--VPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSN 368
L R +P T + +Q ++ +++ + KV+EK ++++N ++ L+
Sbjct: 4829 EAEQTLRFRGALPDDT-EALQSLIDTHKEFMK-----KVEEK-RVDVNSAVAMGEVILA- 4880
Query: 369 RPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE-- 426
++ I + W + +A +EE L + +RL+ + A + E
Sbjct: 4881 -----VCHPDCITTIKH-WITIIRAR--FEEVLTWAKQHQQRLETALSELVANAELLEEL 4932
Query: 427 -AWTDGKEAMLKHRDYETA--TLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELN 481
AW E L RD E + +KALI +H+ F ++ Q V+++ + N
Sbjct: 4933 LAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKN 4990
Score = 33.9 bits (76), Expect = 0.71
Identities = 122/631 (19%), Positives = 235/631 (37%), Gaps = 94/631 (14%)
Query: 191 SWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTA 250
S++ +A +H + LI ++ LRKD LD+ + + E + ++A
Sbjct: 939 SYQKVMALWHQLHVNTKSLISWNYLRKD----------------LDLVQTWNLEKLRSSA 982
Query: 251 RPDEKAIMTYVSSFYHAFSGAQKAE---TAANRI--------CKV----LAVNQENEHLM 295
+ IM + + Y F + + A+R+ CK L + ENE
Sbjct: 983 PGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKE 1042
Query: 296 EDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYR----RVHKPPKVQEKC 351
E K+ L+ IR + E RV K IQ + D ++ R+ + QE
Sbjct: 1043 ETVAKMYISELKNIRLRLEEYEQRVV-KRIQSLASSRTDRDAWQDNALRIAEQEHTQEDL 1101
Query: 352 Q-LEINFNTLQTK----LRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNE-- 404
Q L + + + K L S + +P+ ++ + H+ Y L
Sbjct: 1102 QQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDV 1161
Query: 405 -IRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDL 463
+R ++ + L + + K S E A+ H LSD+K + ++
Sbjct: 1162 IVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEI 1221
Query: 464 AAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL 523
A + EQ++ + E N D + ++ ++W H LE + +L
Sbjct: 1222 AKAKVVAEQMSRLTPERN----LDLERYQEKGSQLQERW-------HRVIAQLEIRQSEL 1270
Query: 524 EAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADRE 583
E+I ++ +Y W+E Q+M E+ L Q + + +R
Sbjct: 1271 ESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLSQQTALFAEIERN 1329
Query: 584 REAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSK 643
+ + K +Q+ Y+T+ K ++Q + K A +E Q K
Sbjct: 1330 QTKLDQCQKFSQQ--------------YSTIV------KDYELQLMTYK---AFVESQQK 1366
Query: 644 QQSNEHLRRQFASQANVVGPW--IQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYK 701
RR +S + + ++T+ + ++ + + D L L++ E+ + + K
Sbjct: 1367 SPGKR--RRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEK 1424
Query: 702 PNLDLLEQQH-QLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAK 760
Q+H + ++E L + + T + T I + I +E Q+L+ +
Sbjct: 1425 -------QEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAI--LEQQVLSEELT 1475
Query: 761 GISQEQMQEFRASFNHFDKDHGGALGPEEFK 791
+EQ+ E + F HG L +E K
Sbjct: 1476 -TKKEQVSEAIKTSQIFLAKHGHKLSEKEKK 1505
Score = 30.8 bits (68), Expect = 6.0
Identities = 86/471 (18%), Positives = 176/471 (37%), Gaps = 63/471 (13%)
Query: 229 EVAEKYLDIPKML----DAEDIVNTARPDEKAIMTYVSSFYHAFSG-----AQKAETAAN 279
E+AE + + K+ D +I PD + + S F A+++
Sbjct: 1983 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2042
Query: 280 RICKVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYR 339
I + +V + E L++ ++ +L + + L V Q+ + + +D
Sbjct: 2043 AIAQSQSVQESLESLLQSIGEVEQNLEG---KQVSSLSSGVIQEALATNMKLKQDI---- 2095
Query: 340 RVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEE 399
++K LE + + ++ +GK+ ++++ ++ L ++ E
Sbjct: 2096 -------ARQKSSLEATREMVTRFMETADSTTAAVLQGKL-AEVSQRFEQLCLQQQEKES 2147
Query: 400 WLLNEIRRLERLDHLAEKFRQ---------------KASIHEAWTDGKEAMLKHRDYETA 444
L + + E +HL+ K +Q I + +E L+ D +
Sbjct: 2148 SLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQE- 2206
Query: 445 TLSDIKALIRKHEA--FESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQW 502
L ++ L+ + + F DL HQDRV+ + EL + + + CQ +Q
Sbjct: 2207 NLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK-TVKEREKDASSCQ---EQL 2262
Query: 503 DALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHT-IE 561
D L + ++ L++TE + E + A +E L D T +E
Sbjct: 2263 DEFRKLVRTFQKWLKETEGSIPP-----TETSMSAKELEKQIEHLKSLLDDWASKGTLVE 2317
Query: 562 EI--EGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQII 619
EI +G + + T PD+ + +IL + N +
Sbjct: 2318 EINCKGTSLENLIMEITAPDSQGKTGSILP--SVGSSVGSVNGYHTCKDLTEIQCDMSDV 2375
Query: 620 NSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKME 670
N K+EK+ ++ +R +L Q+ + + +AN V W+++K E
Sbjct: 2376 NLKYEKLGGVLHERQESL-------QAILNRMEEVHKEANSVLQWLESKEE 2419
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 215 bits (548), Expect = 1e-55
Identities = 162/511 (31%), Positives = 260/511 (50%), Gaps = 61/511 (11%)
Query: 52 QRKTFTAWCNSHLRKAGTQ-IENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKIN 110
Q+KTFT W N+ K+G I ++ D +DG KL+ LLE ++G LPK ERG RVH +N
Sbjct: 33 QKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPK-ERGSTRVHALN 91
Query: 111 NVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDI------SVEETS 164
NVN+ L + V+LV+IG +IVDGN K+TLG++W+IIL + ++D+ +++T+
Sbjct: 92 NVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTN 151
Query: 165 AKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNL 224
+++ LL W ++ T PY VNV NF SW DGLAFNA++HRH+P+L +DK+ K P+ L
Sbjct: 152 SEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERL 211
Query: 225 NNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKV 284
+AF A+ YL I K+LD ED+ PD+K+I+ Y++S + Q+ A R
Sbjct: 212 EHAFSKAQTYLGIEKLLDPEDVA-VQLPDKKSIIMYLTSLFEVL--PQQVTIDAIR---- 264
Query: 285 LAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQ----KTIQEMQQKLEDFRDYRR 340
E E L Y+K + I+ T P E P+ T+ E+ L+ ++
Sbjct: 265 -----EVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALE 319
Query: 341 ------VHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM----PSEGKMVSDINNGWQHL 390
+ QE Q +I+ + + K + + AFM + + S + G Q +
Sbjct: 320 EVLTWLLSAEDTFQE--QDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLI 377
Query: 391 EQAEKGYEE--------WLLN---EIRRLERLDH-------LAEKFRQKASIHEAWTDGK 432
Q EE LLN E R+E +D L E +++ AW
Sbjct: 378 TQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLT 437
Query: 433 EAMLKHRDYETATLSD----IKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDS 488
E + + ET L D ++ L+ +H++ +SDL A Q +V + + ++E +
Sbjct: 438 EERI--QKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESA 495
Query: 489 HNV-NTRCQKICDQWDALGSLTHSRREALEK 518
+ + QK+ ++W A+ T R L++
Sbjct: 496 TAILEDQLQKLGERWTAVCRWTEERWNRLQE 526
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/356 (19%), Positives = 133/356 (37%), Gaps = 39/356 (10%)
Query: 428 WTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQEL---NELD 484
W E + +D + + ++K HEAF +L AHQ V + +L L
Sbjct: 324 WLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLS 383
Query: 485 YYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWM 544
+ + + + +W+AL +E ++Q D L K+ + W+
Sbjct: 384 DEEEFEIQEQMTLLNARWEAL---------RVESMDRQSRLHDVLMELQKKQLQQLSAWL 434
Query: 545 ESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIK 604
E +Q M ++++ L ++ KS D + E+ + ++ + E+
Sbjct: 435 TLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDEN---- 490
Query: 605 LSGSNPYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVG 662
SG + + Q+ + +W V + +R + L E Q E L Q +A
Sbjct: 491 -SGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQ--ELLEEQCLLKA---- 543
Query: 663 PWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQE-----A 717
W+ K E + ++ +DQ L R + K ++++ Q + E
Sbjct: 544 -WLTEKEEALNKVQ---TSNFKDQ-KELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVG 598
Query: 718 LIFDN----KHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQE 769
+ DN K N E + W+ L+ + + N+V + I Q+ + E
Sbjct: 599 QLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLE 654
Score = 48.1 bits (113), Expect = 4e-05
Identities = 74/431 (17%), Positives = 167/431 (38%), Gaps = 67/431 (15%)
Query: 294 LMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQ-EKCQ 352
LME +K L W+ T E+R+ + + ++ + HK + E Q
Sbjct: 419 LMELQKKQLQQLSAWLTLT----EERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQ 474
Query: 353 LEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLD 412
+++N T + N S + + + Q L + W RL+ ++
Sbjct: 475 VKVNSLTHMVVIVDEN------SGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEIN 528
Query: 413 HLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKAL---IRKHEAFESDLAAHQDR 469
L ++ ++ + +AW KE L +T+ D K L +R+ + D+ +
Sbjct: 529 ILWQELLEEQCLLKAWLTEKEEAL--NKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQT 586
Query: 470 VEQIAAIAQELNEL--DYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQL-EAI 526
++Q++ I Q++ +L + S +N+ +++ +WD+L + LE + Q+ +A+
Sbjct: 587 LDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSL-------VQRLEDSSNQVTQAV 639
Query: 527 DQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREA 586
+L M + ++ T+ E I+ + + P ++R+
Sbjct: 640 AKL-----------------GMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQI 682
Query: 587 ILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIIN--SKWEKVQQLVPKRDHALLEEQSKQ 644
H+ + + ++ +++N KW+ Q +++ +++ S+
Sbjct: 683 ---------------HVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEM 727
Query: 645 -------QSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSI 697
+ + R A + N G + +M + G + E+ LE S K + +
Sbjct: 728 KKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHL 787
Query: 698 VDYKPNLDLLE 708
D + + L E
Sbjct: 788 EDLERKIQLQE 798
Score = 39.7 bits (91), Expect = 0.013
Identities = 64/320 (20%), Positives = 130/320 (40%), Gaps = 57/320 (17%)
Query: 275 ETAANRICKVLAVNQENEHLMEDYEKLAS------DLLEWIRRTIP-WLEDRVPQKTIQE 327
+T ++ K +A + L E EK A+ ++ EW+ + +LE K+ +E
Sbjct: 1103 QTQLEKLSKEIAT--QKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEE 1160
Query: 328 MQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGW 387
++ +E+ + + ++ Q E+ L+ ++L + + + +G
Sbjct: 1161 LESAVEEMKRAK--------EDVLQKEVRVKILKDNIKL------------LAAKVPSGG 1200
Query: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKA-SIHEAWTDGKEAMLKHRDYETATL 446
Q L LN + LE L + R K ++ E W+ E +L + D ET L
Sbjct: 1201 QELTSE--------LNVV--LENYQLLCNRIRGKCHTLEEVWSCWIE-LLHYLDLETTWL 1249
Query: 447 SDIKALIRKHE--------------AFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVN 492
+ ++ ++ E + ES L D QI + Q L + D ++
Sbjct: 1250 NTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDI-IS 1308
Query: 493 TRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQ 552
+ + +++ L L S++ +LEK + L DQ+ + + + + + D
Sbjct: 1309 EKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRI 1368
Query: 553 DMF-IVHTIEEIEGLISAHD 571
D F + ++I+ ISAH+
Sbjct: 1369 DAFQVPQEAQKIQAEISAHE 1388
Score = 34.7 bits (78), Expect = 0.42
Identities = 75/430 (17%), Positives = 172/430 (40%), Gaps = 68/430 (15%)
Query: 298 YEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINF 357
++ ++++LL WI + W Q T + K++D + ++ K + +++ ++
Sbjct: 692 FDAISAELLNWI---LKW--KTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRAD 746
Query: 358 NTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEK 417
QT L + M EG +I N + + K + L + R+++ + +
Sbjct: 747 ELNQTGQILVEQ---MGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAY 803
Query: 418 FRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIA 477
F+Q + + KE +KH ++ + +L + ++L ++E A
Sbjct: 804 FKQLDELEKV-IKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARA-- 860
Query: 478 QELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAID--QLHLEYAK 535
C + Q A + L + + EA++ Q HLE
Sbjct: 861 ----------------SCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENEL 904
Query: 536 RAAPFNNWMESAMEDLQDMF------------IVHTIEEIEGLISAHDQFKSTLPDA-DR 582
+ P + ++E+ ++ L+D+ +++ + ++E + Q K TL + +
Sbjct: 905 KGQPGHAYLET-LKTLKDVLNDSENKAQVSLNVLNDLAKVEKAL----QEKKTLDEILEN 959
Query: 583 EREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLE--- 639
++ A+ + +E + + ++ H + + KW K++ LV K H L E
Sbjct: 960 QKPALHKLAEETKALEKNVHPDVEKLYKQEF---DDVQGKWNKLKVLVSKDLHLLEEIAL 1016
Query: 640 ------------EQSKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQL 687
E+ + L +Q A+Q + G +Q ++++ E+ T+E L
Sbjct: 1017 TLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAG--LQRQLDQCSAFVNEIE-TIESSL 1073
Query: 688 SHLKQYERSI 697
++K+ E ++
Sbjct: 1074 KNMKEIETNL 1083
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,555,135
Number of Sequences: 37866
Number of extensions: 1462425
Number of successful extensions: 6817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 200
Number of HSP's that attempted gapping in prelim test: 5661
Number of HSP's gapped (non-prelim): 981
length of query: 911
length of database: 18,247,518
effective HSP length: 111
effective length of query: 800
effective length of database: 14,044,392
effective search space: 11235513600
effective search space used: 11235513600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.