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Search of human proteins with 24586688
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24586688 ankyrin repeat and SOCS box-containing protein 16
[Homo sapiens]
(453 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 922 0.0
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 290 1e-78
gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo sap... 285 5e-77
gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1... 253 3e-67
gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2... 221 1e-57
gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isof... 196 4e-50
gi|22208964 ankyrin repeat and SOCS box-containing protein 4 iso... 142 8e-34
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 101 1e-21
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 101 1e-21
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 101 1e-21
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 101 1e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 100 2e-21
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 100 5e-21
gi|121582655 ankyrin repeat domain 35 [Homo sapiens] 98 1e-20
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 97 2e-20
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 97 2e-20
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 97 4e-20
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 97 4e-20
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 97 4e-20
gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2 [... 94 2e-19
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 94 2e-19
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 94 2e-19
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 93 4e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 93 4e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 93 4e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 93 4e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 93 4e-19
gi|55770876 notch4 preproprotein [Homo sapiens] 93 6e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 92 1e-18
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 91 3e-18
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 922 bits (2382), Expect = 0.0
Identities = 453/453 (100%), Positives = 453/453 (100%)
Query: 1 MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPA 60
MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPA
Sbjct: 1 MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPA 60
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA 120
VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA
Sbjct: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA 120
Query: 121 RGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL 180
RGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL
Sbjct: 121 RGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL 180
Query: 181 HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRT 240
HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRT
Sbjct: 181 HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRT 240
Query: 241 SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLA 300
SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLA
Sbjct: 241 SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLA 300
Query: 301 ELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCA 360
ELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCA
Sbjct: 301 ELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCA 360
Query: 361 NFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVR 420
NFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVR
Sbjct: 361 NFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVR 420
Query: 421 ARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ 453
ARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
Sbjct: 421 ARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ 453
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 290 bits (743), Expect = 1e-78
Identities = 174/433 (40%), Positives = 239/433 (55%), Gaps = 22/433 (5%)
Query: 42 PSSPRARLTRPHRS------------CRDPAVHQALFSGNLQQVQALFQDEEAANMIVET 89
PS+P R+ RPH C+D A+ AL++G+L ++Q LF A++++E+
Sbjct: 19 PSAPACRIWRPHSRPAWEPPRPSPLLCQDMALQNALYTGDLARLQELFPPHSTADLLLES 78
Query: 90 VSNQLAWSAEQ-GFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALH 148
+ + WS+ Q G W LT + + T PL +A +RG+T+ R L+R+ A D+ GGR ALH
Sbjct: 79 RAAEPRWSSHQRGLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALH 138
Query: 149 EACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGE 208
EACA CV +LL GA N+ ++G PLHLC P +L+CA+LLL GA V+ + E
Sbjct: 139 EACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEE 198
Query: 209 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-----AGAEGPGSCRRH 263
+ETPLHVAA G + L L GA R ++G T L AC + + + R
Sbjct: 199 EEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARC 258
Query: 264 QAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDC 323
LL AGADA AA + + PLH AC G + ELLL G A + GHTP+ C
Sbjct: 259 LQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHC 318
Query: 324 ALQAVQDSPNWEPEVLFAALLDYGAQPV----RPEMLKHCANFPRALEVLLNAYPCVPSC 379
ALQ + PE + ALL++GA V P++L+ + PR +EVL+N Y V
Sbjct: 319 ALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLP 378
Query: 380 ETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPL 439
E V V PE ++H+ FYSS +V QPR LQHL+R A+R+ L Q RLPLPP
Sbjct: 379 EEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPR 438
Query: 440 LRDYLLLRVEGCI 452
L YL L EG +
Sbjct: 439 LLRYLQLDFEGVL 451
>gi|157743292 ankyrin repeat and SOCS box-containing 18 [Homo
sapiens]
Length = 466
Score = 285 bits (730), Expect = 5e-77
Identities = 167/413 (40%), Positives = 225/413 (54%), Gaps = 20/413 (4%)
Query: 57 RDPAVH--QALFSGNLQQVQAL----FQDEEAANMIVETVSNQLAWSAEQ-------GFW 103
+DP+ + G+L ++ L FQD AN++ E +++ W + G W
Sbjct: 56 KDPSAQLPTGMLLGDLDHLKPLMDQFFQD---ANVVFEINKDEMEWQVKSPATFGLSGLW 112
Query: 104 VLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLL 163
L K + T PL IA A G+T C RHL+ +GA+ DA GGR ALHEAC CVRLLL
Sbjct: 113 TLEYKRELTTPLCIAAAHGHTACVRHLLGRGADPDASPGGRGALHEACLGGHTACVRLLL 172
Query: 164 TFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLE 223
A ++L+ EG PLHLC SL CA+ LLE GA+V G ++TPLHVAA RGL+
Sbjct: 173 QHRADPDLLSAEGLAPLHLCRTAASLGCAQALLEHGASVQRVGGTGRDTPLHVAAQRGLD 232
Query: 224 QHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRK 283
+H LYL GA V R +GETAL+ AC A P R LL GA+A A
Sbjct: 233 EHARLYLGRGAHVDARNGRGETALSAACGAARRPDEHGRCLRLCALLLRRGAEADARDED 292
Query: 284 RHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAAL 343
+PLH AC + LA LLLR+GA A + G +P+ LQ + P+ AL
Sbjct: 293 ERSPLHKACGHASHSLARLLLRHGADAGALDYGGASPLGRVLQTASCALQASPQRTVQAL 352
Query: 344 LDYGAQPVRPE----MLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYS 399
L++G+ V P+ +LK CA+ P +EVL N+YP + E+W E + E+++ H+ FY
Sbjct: 353 LNHGSPTVWPDAFPKVLKTCASVPAVIEVLFNSYPQLCLSESWKEVIPEEVFQMHKPFYQ 412
Query: 400 SALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452
S + PR LQHL R A+R G RC LPLP L++YLLL +G +
Sbjct: 413 SLFALALTPRCLQHLCRCALRRLFGKRCFDLIPLLPLPKPLQNYLLLEPQGVL 465
>gi|215598819 ankyrin repeat and SOCS box-containing 10 isoform 1
[Homo sapiens]
Length = 512
Score = 253 bits (645), Expect = 3e-67
Identities = 151/359 (42%), Positives = 199/359 (55%), Gaps = 9/359 (2%)
Query: 103 WVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLL 162
W LT + + T PL +A +RG+T+ R L+R+ A D+ GGR ALHEACA CV +L
Sbjct: 153 WSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL 212
Query: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
L GA N+ ++G PLHLC P +L+CA+LLL GA V+ + E +ETPLHVAA G
Sbjct: 213 LVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272
Query: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-----AGAEGPGSCRRHQAAARRLLEAGADA 277
+ L L GA R ++G T L AC + + + R LL AGADA
Sbjct: 273 VELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADA 332
Query: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPE 337
AA + + PLH AC G + ELLL G A + GHTP+ CALQ + PE
Sbjct: 333 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPE 392
Query: 338 VLFAALLDYGAQPV----RPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKE 393
+ ALL++GA V P++L+ + PR +EVL+N Y V E V V PE ++
Sbjct: 393 HVVRALLNHGAVRVWPGALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQK 452
Query: 394 HEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452
H+ FYSS +V QPR LQHL+R A+R+ L Q RLPLPP L YL L EG +
Sbjct: 453 HQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 511
Score = 57.8 bits (138), Expect = 2e-08
Identities = 46/126 (36%), Positives = 57/126 (45%), Gaps = 9/126 (7%)
Query: 186 PESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGET 245
PE + + + A +L E TPLHVAA+RG + + L L A G T
Sbjct: 137 PERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPD-SAPGGRT 195
Query: 246 ALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLR 305
AL+ ACA H A LL AGAD A + PLH G AELLLR
Sbjct: 196 ALHEACAAG--------HTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECAELLLR 247
Query: 306 YGARAE 311
+GAR +
Sbjct: 248 FGARVD 253
>gi|215598824 ankyrin repeat and SOCS box-containing 10 isoform 2
[Homo sapiens]
Length = 474
Score = 221 bits (562), Expect = 1e-57
Identities = 139/355 (39%), Positives = 180/355 (50%), Gaps = 39/355 (10%)
Query: 103 WVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLL 162
W LT + + T PL +A +RG+T+ R L+R+ A D+ GGR ALHEACA CV +L
Sbjct: 153 WSLTYEEELTTPLHVAASRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVL 212
Query: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
L GA N+ ++G PLHLC P +L+CA+LLL GA V+ + E +ETPLHVAA G
Sbjct: 213 LVAGADPNIADQDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGH 272
Query: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-----AGAEGPGSCRRHQAAARRLLEAGADA 277
+ L L GA R ++G T L AC + + + R LL AGADA
Sbjct: 273 VELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADA 332
Query: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPE 337
AA + + PLH AC G + ELLL G A + GHTP+ CALQ + PE
Sbjct: 333 DAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPE 392
Query: 338 VLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAF 397
+ ALL++GA V P L K+H+ F
Sbjct: 393 HVVRALLNHGAVRVWPGALP----------------------------------KKHQRF 418
Query: 398 YSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452
YSS +V QPR LQHL+R A+R+ L Q RLPLPP L YL L EG +
Sbjct: 419 YSSLFALVRQPRSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVL 473
>gi|7706379 ankyrin repeat and SOCS box-containing protein 4 isoform
a [Homo sapiens]
Length = 426
Score = 196 bits (498), Expect = 4e-50
Identities = 134/403 (33%), Positives = 204/403 (50%), Gaps = 13/403 (3%)
Query: 63 QALFSGNLQQVQA-LFQDEEAANMIVETVS-NQLAWSAEQGFWVLTPKTKQT--APLAIA 118
+AL S + +++A L Q + + + E N + S +QG+W+ + K K + L ++
Sbjct: 23 EALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLS 82
Query: 119 TARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTT 178
G+ +C L+ A ++ R G+ LH AC A DCV++L GAK N + G T
Sbjct: 83 VLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHT 142
Query: 179 PLHLCTIPESLQCAKLLLEAGATVNLAA-GESQETPLHVAAARGLEQHVALYLEHGADVG 237
LH CT P S+ CAK L+ GA VN+ + +ETPLH AA GL + VA Y+EHGA V
Sbjct: 143 ALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVD 202
Query: 238 LRTSQGETALNTACAGA---EGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACAN 294
+ ET L A A + H R LL+ A+ A +PLH A N
Sbjct: 203 SVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWN 262
Query: 295 GCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP- 353
L ++L GA A + + G + L+ P +PE+ + LL++GA + P
Sbjct: 263 CDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPP 322
Query: 354 ---EMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCM-VNQPR 409
++++ C + P+A+EV++NAY + W A+ + +++ FY S + N PR
Sbjct: 323 QFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPR 382
Query: 410 QLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCI 452
L HL+R A+R L +RC + L LP L+ YLLL EG I
Sbjct: 383 TLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGII 425
>gi|22208964 ankyrin repeat and SOCS box-containing protein 4
isoform b [Homo sapiens]
Length = 349
Score = 142 bits (357), Expect = 8e-34
Identities = 98/299 (32%), Positives = 147/299 (49%), Gaps = 8/299 (2%)
Query: 63 QALFSGNLQQVQA-LFQDEEAANMIVETVS-NQLAWSAEQGFWVLTPKTKQT--APLAIA 118
+AL S + +++A L Q + + + E N + S +QG+W+ + K K + L ++
Sbjct: 23 EALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLS 82
Query: 119 TARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTT 178
G+ +C L+ A ++ R G+ LH AC A DCV++L GAK N + G T
Sbjct: 83 VLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHT 142
Query: 179 PLHLCTIPESLQCAKLLLEAGATVNLAA-GESQETPLHVAAARGLEQHVALYLEHGADVG 237
LH CT P S+ CAK L+ GA VN+ + +ETPLH AA GL + VA Y+EHGA V
Sbjct: 143 ALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVD 202
Query: 238 LRTSQGETALNTACAGA---EGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACAN 294
+ ET L A A + H R LL+ A+ A +PLH A N
Sbjct: 203 SVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWN 262
Query: 295 GCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP 353
L ++L GA A + + G + L+ P +PE+ + LL++GA + P
Sbjct: 263 CDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYP 321
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 101 bits (252), Expect = 1e-21
Identities = 89/328 (27%), Positives = 138/328 (42%), Gaps = 29/328 (8%)
Query: 63 QALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTP-------------KT 109
+A G++ V+ L + + N E + L + G++ L
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAK 168
PL A++ GY D + L+ A+++++ G AL ACA D V++LL GA
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 169 ANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228
E G TPL ++ A++LL+ GA +N + E +E+ L +A +G V
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 229 YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPL 288
LE GAD +T + TAL AC H AR LL++GA +PL
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDG--------HVEVARLLLDSGAQVNMPADSFESPL 442
Query: 289 HNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
A G LA LL+ GA E N G+TP+ ++A ++ +L A + A
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPL---MEAAREGHEEMVALLLAQGANINA 499
Query: 349 QPVRPE----MLKHCANFPRALEVLLNA 372
Q + L C F + L+ A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKA 527
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/186 (33%), Positives = 82/186 (44%), Gaps = 10/186 (5%)
Query: 125 DCARHLIRQGAELDARVG--GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHL 182
+ A L R AE G +L EAC+ + VR LL G N TEEG + L L
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 183 CTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQ 242
+ A++LL A V + TPL A++ G V L L H ADV +++
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 243 GETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAEL 302
G TAL ACAG + LL GA+ HTPL A + G +A +
Sbjct: 305 GNTALTYACAGG--------FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 303 LLRYGA 308
LL +GA
Sbjct: 357 LLDHGA 362
Score = 68.9 bits (167), Expect = 9e-12
Identities = 61/228 (26%), Positives = 89/228 (39%), Gaps = 45/228 (19%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVGG-RAALHEACARAQFDCVRLLLTFGAKANV-- 171
L +A +G+ D R L+ GA+ + + AL EAC + RLLL GA+ N+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435
Query: 172 -------------------------------LTEEGTTPLHLCTIPESLQCAKLLLEAGA 200
+ +EG TPL + LLL GA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 201 TVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
+N E+QET L +A G + ++ GAD+ L C+ S
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL-----------GCSTPLMEASQ 544
Query: 261 RRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGA 308
H + LL +GA+ A T L AC NG +A++LL+ GA
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 592
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 101 bits (252), Expect = 1e-21
Identities = 89/328 (27%), Positives = 138/328 (42%), Gaps = 29/328 (8%)
Query: 63 QALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTP-------------KT 109
+A G++ V+ L + + N E + L + G++ L
Sbjct: 200 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 259
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAK 168
PL A++ GY D + L+ A+++++ G AL ACA D V++LL GA
Sbjct: 260 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 319
Query: 169 ANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228
E G TPL ++ A++LL+ GA +N + E +E+ L +A +G V
Sbjct: 320 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 379
Query: 229 YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPL 288
LE GAD +T + TAL AC H AR LL++GA +PL
Sbjct: 380 LLEAGADQEHKTDEMHTALMEACMDG--------HVEVARLLLDSGAQVNMPADSFESPL 431
Query: 289 HNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
A G LA LL+ GA E N G+TP+ ++A ++ +L A + A
Sbjct: 432 TLAACGGHVELAALLIERGANLEEVNDEGYTPL---MEAAREGHEEMVALLLAQGANINA 488
Query: 349 QPVRPE----MLKHCANFPRALEVLLNA 372
Q + L C F + L+ A
Sbjct: 489 QTEETQETALTLACCGGFSEVADFLIKA 516
Score = 75.5 bits (184), Expect = 9e-14
Identities = 74/253 (29%), Positives = 103/253 (40%), Gaps = 28/253 (11%)
Query: 76 LFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPL-AIATARGYTD--------- 125
+ E+ N +++T S S +G + T + A L A+ A + D
Sbjct: 107 ILDQEDLDNPVLKTTSEIFLSSTAEGADLRTVDPETQARLEALLEAAAFADPEVLRRLTS 166
Query: 126 --------CARHLIRQGAELDARVG--GRAALHEACARAQFDCVRLLLTFGAKANVLTEE 175
A L R AE G +L EAC+ + VR LL G N TEE
Sbjct: 167 SVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEE 226
Query: 176 GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGAD 235
G + L L + A++LL A V + TPL A++ G V L L H AD
Sbjct: 227 GESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 286
Query: 236 VGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANG 295
V +++ G TAL ACAG + LL GA+ HTPL A + G
Sbjct: 287 VNSQSATGNTALTYACAGG--------FVDIVKVLLNEGANIEDHNENGHTPLMEAASAG 338
Query: 296 CGGLAELLLRYGA 308
+A +LL +GA
Sbjct: 339 HVEVARVLLDHGA 351
Score = 68.9 bits (167), Expect = 9e-12
Identities = 61/228 (26%), Positives = 89/228 (39%), Gaps = 45/228 (19%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVGG-RAALHEACARAQFDCVRLLLTFGAKANV-- 171
L +A +G+ D R L+ GA+ + + AL EAC + RLLL GA+ N+
Sbjct: 365 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 424
Query: 172 -------------------------------LTEEGTTPLHLCTIPESLQCAKLLLEAGA 200
+ +EG TPL + LLL GA
Sbjct: 425 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 484
Query: 201 TVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
+N E+QET L +A G + ++ GAD+ L C+ S
Sbjct: 485 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL-----------GCSTPLMEASQ 533
Query: 261 RRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGA 308
H + LL +GA+ A T L AC NG +A++LL+ GA
Sbjct: 534 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGA 581
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 101 bits (252), Expect = 1e-21
Identities = 89/328 (27%), Positives = 138/328 (42%), Gaps = 29/328 (8%)
Query: 63 QALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTP-------------KT 109
+A G++ V+ L + + N E + L + G++ L
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAK 168
PL A++ GY D + L+ A+++++ G AL ACA D V++LL GA
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 169 ANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228
E G TPL ++ A++LL+ GA +N + E +E+ L +A +G V
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 229 YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPL 288
LE GAD +T + TAL AC H AR LL++GA +PL
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDG--------HVEVARLLLDSGAQVNMPADSFESPL 442
Query: 289 HNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
A G LA LL+ GA E N G+TP+ ++A ++ +L A + A
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPL---MEAAREGHEEMVALLLAQGANINA 499
Query: 349 QPVRPE----MLKHCANFPRALEVLLNA 372
Q + L C F + L+ A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKA 527
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/219 (30%), Positives = 102/219 (46%), Gaps = 14/219 (6%)
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFG 166
+TK T PL++A + G + L+ +GA + R V L A + + +++LL G
Sbjct: 1120 RTKDT-PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178
Query: 167 AKANVLTEE--GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQ 224
A+ N T G +PL L + + KLLL+ G+ +N ++ T L +A +G +
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238
Query: 225 HVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARA--AGR 282
V+L L+ A+V R G T L A +G + R LL+ GAD A
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGG--------YAEVGRVLLDKGADVNAPPVPS 1290
Query: 283 KRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPM 321
R T L A G ELL+ GA +V N G+TP+
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1329
Score = 77.8 bits (190), Expect = 2e-14
Identities = 87/292 (29%), Positives = 119/292 (40%), Gaps = 44/292 (15%)
Query: 57 RDPAVHQALFSGNLQQVQALFQ---DEEAANMIVETVSNQLAWSA---------EQGFWV 104
++ A+ A + G+L V+ L + D+E + T + + G V
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431
Query: 105 LTPKTKQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLL 163
P +PL +A G+ + A LI +GA L+ G L EA + V LLL
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Query: 164 TFGAKANVLTEEGT-TPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
GA N TEE T L L + A L++AGA + L TPL A+ G
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGH 547
Query: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-------------AGA----EGPGSCRRHQA 265
+ V L GA+V T+ G+TAL AC AGA E G
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 607
Query: 266 AARR--------LLEAGADA-RAAGRKRHTPLHNACANGCGGLAELLLRYGA 308
AAR L+ GA+ RA HT + ACA G + ELLL +GA
Sbjct: 608 AARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659
Score = 76.3 bits (186), Expect = 5e-14
Identities = 67/247 (27%), Positives = 98/247 (39%), Gaps = 45/247 (18%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVGG-RAALHEACARAQFDCVRLLLTFGAKANV-- 171
L +A +G+ D R L+ GA+ + + AL EAC + RLLL GA+ N+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435
Query: 172 -------------------------------LTEEGTTPLHLCTIPESLQCAKLLLEAGA 200
+ +EG TPL + LLL GA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 201 TVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
+N E+QET L +A G + ++ GAD+ L C+ S
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL-----------GCSTPLMEASQ 544
Query: 261 RRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
H + LL +GA+ A T L AC NG +A++LL+ GA E + G TP
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 604
Query: 321 MDCALQA 327
+ A +A
Sbjct: 605 LMKAARA 611
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/186 (33%), Positives = 82/186 (44%), Gaps = 10/186 (5%)
Query: 125 DCARHLIRQGAELDARVG--GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHL 182
+ A L R AE G +L EAC+ + VR LL G N TEEG + L L
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 183 CTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQ 242
+ A++LL A V + TPL A++ G V L L H ADV +++
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 243 GETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAEL 302
G TAL ACAG + LL GA+ HTPL A + G +A +
Sbjct: 305 GNTALTYACAGG--------FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 303 LLRYGA 308
LL +GA
Sbjct: 357 LLDHGA 362
Score = 73.2 bits (178), Expect = 5e-13
Identities = 55/196 (28%), Positives = 93/196 (47%), Gaps = 11/196 (5%)
Query: 113 APLAIATARGYTDCARHLIRQGAELDARV--GGRAALHEACARAQFDCVRLLLTFGAKAN 170
+PL +A G+ + L+ G++++A++ AL AC + + + V LLL A
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 171 VLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA-AGESQETPLHVAAARGLEQHVALY 229
+ G TPL + ++LL+ GA VN S++T L +AA +G + L
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 230 LEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLH 289
+ GA + +R +G T L A G H + L++AGAD AA ++ TPL
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGG--------HFDVVQLLVQAGADVDAADNRKITPLM 1363
Query: 290 NACANGCGGLAELLLR 305
+A G + + L++
Sbjct: 1364 SAFRKGHVKVVQYLVK 1379
Score = 67.0 bits (162), Expect = 3e-11
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 15/219 (6%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVG---GRAALHEACARAQFDCVRLLLTFGAKAN 170
PL++A + GY + + L+ GAE+++R G G + L A V+LLL G+ N
Sbjct: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 171 VLTEEG-TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALY 229
E T L L + LLL+ A V A ++ TPL AA+ G + +
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1276
Query: 230 LEHGADVGLRT--SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L+ GADV S +TAL A + H L+ GA +K +TP
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAAD--------KGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
L A G + +LL++ GA + + TP+ A +
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFR 1367
Score = 66.6 bits (161), Expect = 4e-11
Identities = 50/150 (33%), Positives = 66/150 (44%), Gaps = 15/150 (10%)
Query: 112 TAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKAN 170
+ PL A+ G+ + ++L+ GA + A G AL AC D +LL GA
Sbjct: 536 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 171 VLTEEGTTPL-------HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLE 223
+E G TPL HLCT+ + L+ GA VN A + T + +A A G
Sbjct: 596 HESEGGRTPLMKAARAGHLCTV-------QFLISKGANVNRATANNDHTVVSLACAGGHL 648
Query: 224 QHVALYLEHGADVGLRTSQGETALNTACAG 253
V L L HGAD R G T L A G
Sbjct: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/204 (27%), Positives = 84/204 (41%), Gaps = 28/204 (13%)
Query: 146 ALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA 205
AL ACA + V +L+ AK ++G TPL L + ++LL+ G +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 206 AGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-------------A 252
+ +++TPL +A + G ++ V L L GA+ R T L+ A A
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 253 GAE-----------GP---GSCRRHQAAARRLLEAGADARA-AGRKRHTPLHNACANGCG 297
GAE P + H A + LL+ G+D A R+T L AC G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 298 GLAELLLRYGARAEVPNGAGHTPM 321
+ LLL A E G TP+
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPL 1261
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 12/162 (7%)
Query: 166 GAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG--ESQETPLHVAAARGLE 223
G+ ++ T E TP C+ S ++ + +V++ A + +T L +A A G E
Sbjct: 1010 GSNSSSQTTECLTP-ESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHE 1068
Query: 224 QHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAG-R 282
+ V++ + A + R +G T L A H LL+ G D A R
Sbjct: 1069 ELVSVLIARDAKIEHRDKKGFTPLILAATAG--------HVGVVEILLDKGGDIEAQSER 1120
Query: 283 KRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
+ TPL AC+ G + +LLL GA E N + +TP+ A
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 101 bits (252), Expect = 1e-21
Identities = 89/328 (27%), Positives = 138/328 (42%), Gaps = 29/328 (8%)
Query: 63 QALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTP-------------KT 109
+A G++ V+ L + + N E + L + G++ L
Sbjct: 211 EACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNK 270
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAK 168
PL A++ GY D + L+ A+++++ G AL ACA D V++LL GA
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN 330
Query: 169 ANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228
E G TPL ++ A++LL+ GA +N + E +E+ L +A +G V
Sbjct: 331 IEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRF 390
Query: 229 YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPL 288
LE GAD +T + TAL AC H AR LL++GA +PL
Sbjct: 391 LLEAGADQEHKTDEMHTALMEACMDG--------HVEVARLLLDSGAQVNMPADSFESPL 442
Query: 289 HNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
A G LA LL+ GA E N G+TP+ ++A ++ +L A + A
Sbjct: 443 TLAACGGHVELAALLIERGANLEEVNDEGYTPL---MEAAREGHEEMVALLLAQGANINA 499
Query: 349 QPVRPE----MLKHCANFPRALEVLLNA 372
Q + L C F + L+ A
Sbjct: 500 QTEETQETALTLACCGGFSEVADFLIKA 527
Score = 78.2 bits (191), Expect = 1e-14
Identities = 67/219 (30%), Positives = 102/219 (46%), Gaps = 14/219 (6%)
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFG 166
+TK T PL++A + G + L+ +GA + R V L A + + +++LL G
Sbjct: 1120 RTKDT-PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1178
Query: 167 AKANVLTEE--GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQ 224
A+ N T G +PL L + + KLLL+ G+ +N ++ T L +A +G +
Sbjct: 1179 AEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAE 1238
Query: 225 HVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARA--AGR 282
V+L L+ A+V R G T L A +G + R LL+ GAD A
Sbjct: 1239 VVSLLLDRKANVEHRAKTGLTPLMEAASGG--------YAEVGRVLLDKGADVNAPPVPS 1290
Query: 283 KRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPM 321
R T L A G ELL+ GA +V N G+TP+
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPL 1329
Score = 77.8 bits (190), Expect = 2e-14
Identities = 87/292 (29%), Positives = 119/292 (40%), Gaps = 44/292 (15%)
Query: 57 RDPAVHQALFSGNLQQVQALFQ---DEEAANMIVETVSNQLAWSA---------EQGFWV 104
++ A+ A + G+L V+ L + D+E + T + + G V
Sbjct: 372 KESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 431
Query: 105 LTPKTKQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLL 163
P +PL +A G+ + A LI +GA L+ G L EA + V LLL
Sbjct: 432 NMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLL 491
Query: 164 TFGAKANVLTEEGT-TPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
GA N TEE T L L + A L++AGA + L TPL A+ G
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGH 547
Query: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-------------AGA----EGPGSCRRHQA 265
+ V L GA+V T+ G+TAL AC AGA E G
Sbjct: 548 LELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 607
Query: 266 AARR--------LLEAGADA-RAAGRKRHTPLHNACANGCGGLAELLLRYGA 308
AAR L+ GA+ RA HT + ACA G + ELLL +GA
Sbjct: 608 AARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGA 659
Score = 76.3 bits (186), Expect = 5e-14
Identities = 67/247 (27%), Positives = 98/247 (39%), Gaps = 45/247 (18%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVGG-RAALHEACARAQFDCVRLLLTFGAKANV-- 171
L +A +G+ D R L+ GA+ + + AL EAC + RLLL GA+ N+
Sbjct: 376 LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 435
Query: 172 -------------------------------LTEEGTTPLHLCTIPESLQCAKLLLEAGA 200
+ +EG TPL + LLL GA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 201 TVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
+N E+QET L +A G + ++ GAD+ L C+ S
Sbjct: 496 NINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL-----------GCSTPLMEASQ 544
Query: 261 RRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
H + LL +GA+ A T L AC NG +A++LL+ GA E + G TP
Sbjct: 545 EGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 604
Query: 321 MDCALQA 327
+ A +A
Sbjct: 605 LMKAARA 611
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/186 (33%), Positives = 82/186 (44%), Gaps = 10/186 (5%)
Query: 125 DCARHLIRQGAELDARVG--GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHL 182
+ A L R AE G +L EAC+ + VR LL G N TEEG + L L
Sbjct: 185 EAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCL 244
Query: 183 CTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQ 242
+ A++LL A V + TPL A++ G V L L H ADV +++
Sbjct: 245 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT 304
Query: 243 GETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAEL 302
G TAL ACAG + LL GA+ HTPL A + G +A +
Sbjct: 305 GNTALTYACAGG--------FVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 303 LLRYGA 308
LL +GA
Sbjct: 357 LLDHGA 362
Score = 73.2 bits (178), Expect = 5e-13
Identities = 55/196 (28%), Positives = 93/196 (47%), Gaps = 11/196 (5%)
Query: 113 APLAIATARGYTDCARHLIRQGAELDARV--GGRAALHEACARAQFDCVRLLLTFGAKAN 170
+PL +A G+ + L+ G++++A++ AL AC + + + V LLL A
Sbjct: 1192 SPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVE 1251
Query: 171 VLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA-AGESQETPLHVAAARGLEQHVALY 229
+ G TPL + ++LL+ GA VN S++T L +AA +G + L
Sbjct: 1252 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Query: 230 LEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLH 289
+ GA + +R +G T L A G H + L++AGAD AA ++ TPL
Sbjct: 1312 IHRGAHIDVRNKKGNTPLWLASNGG--------HFDVVQLLVQAGADVDAADNRKITPLM 1363
Query: 290 NACANGCGGLAELLLR 305
+A G + + L++
Sbjct: 1364 SAFRKGHVKVVQYLVK 1379
Score = 67.0 bits (162), Expect = 3e-11
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 15/219 (6%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVG---GRAALHEACARAQFDCVRLLLTFGAKAN 170
PL++A + GY + + L+ GAE+++R G G + L A V+LLL G+ N
Sbjct: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 171 VLTEEG-TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALY 229
E T L L + LLL+ A V A ++ TPL AA+ G + +
Sbjct: 1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1276
Query: 230 LEHGADVGLRT--SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L+ GADV S +TAL A + H L+ GA +K +TP
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAAD--------KGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
L A G + +LL++ GA + + TP+ A +
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFR 1367
Score = 66.6 bits (161), Expect = 4e-11
Identities = 50/150 (33%), Positives = 66/150 (44%), Gaps = 15/150 (10%)
Query: 112 TAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKAN 170
+ PL A+ G+ + ++L+ GA + A G AL AC D +LL GA
Sbjct: 536 STPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 595
Query: 171 VLTEEGTTPL-------HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLE 223
+E G TPL HLCT+ + L+ GA VN A + T + +A A G
Sbjct: 596 HESEGGRTPLMKAARAGHLCTV-------QFLISKGANVNRATANNDHTVVSLACAGGHL 648
Query: 224 QHVALYLEHGADVGLRTSQGETALNTACAG 253
V L L HGAD R G T L A G
Sbjct: 649 AVVELLLAHGADPTHRLKDGSTMLIEAAKG 678
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/204 (27%), Positives = 84/204 (41%), Gaps = 28/204 (13%)
Query: 146 ALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA 205
AL ACA + V +L+ AK ++G TPL L + ++LL+ G +
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 206 AGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-------------A 252
+ +++TPL +A + G ++ V L L GA+ R T L+ A A
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 253 GAE-----------GP---GSCRRHQAAARRLLEAGADARA-AGRKRHTPLHNACANGCG 297
GAE P + H A + LL+ G+D A R+T L AC G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 298 GLAELLLRYGARAEVPNGAGHTPM 321
+ LLL A E G TP+
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPL 1261
Score = 48.5 bits (114), Expect = 1e-05
Identities = 45/162 (27%), Positives = 72/162 (44%), Gaps = 12/162 (7%)
Query: 166 GAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG--ESQETPLHVAAARGLE 223
G+ ++ T E TP C+ S ++ + +V++ A + +T L +A A G E
Sbjct: 1010 GSNSSSQTTECLTP-ESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHE 1068
Query: 224 QHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAG-R 282
+ V++ + A + R +G T L A H LL+ G D A R
Sbjct: 1069 ELVSVLIARDAKIEHRDKKGFTPLILAATAG--------HVGVVEILLDKGGDIEAQSER 1120
Query: 283 KRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
+ TPL AC+ G + +LLL GA E N + +TP+ A
Sbjct: 1121 TKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 100 bits (250), Expect = 2e-21
Identities = 72/215 (33%), Positives = 103/215 (47%), Gaps = 10/215 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A RG +HL++ GA DA G LH A AR ++ ++LL +GA +
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
T +G TPLHL L+ LL E+ A + A G TPLH+AA G E V+ L+
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMG-ALGAVNWTPLHLAARHGEEAVVSALLQC 648
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GAD G T L+ A R + LLE A+ A + TP H A
Sbjct: 649 GADPNAAEQSGWTPLHLAVQ--------RSTFLSVINLLEHHANVHARNKVGWTPAHLAA 700
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQA 327
G + ++L+ GA+ +V +G TP+ AL++
Sbjct: 701 LKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRS 735
Score = 91.7 bits (226), Expect = 1e-18
Identities = 87/292 (29%), Positives = 117/292 (40%), Gaps = 53/292 (18%)
Query: 111 QTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKA 169
+ PL A+G + R L+ ++D + G L A Q D LLL GA A
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
Query: 170 NVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALY 229
N + E+G PLH A+LLL+ GA V+ E TPLH+AA E L
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGW-TPLHLAAQNNFENVARLL 480
Query: 230 LEHGADVGLRTSQGETALNTAC-------------AGAEGPGSCRR-----HQAAAR--- 268
+ AD L ++G+T L+ A GAE R H A R
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 269 ----RLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
LL++GA A + + PLH A A G + ++LLRYGA E+P G TP+ A
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLA 600
Query: 325 L-----------------QAVQDSPNWEP---------EVLFAALLDYGAQP 350
+ NW P E + +ALL GA P
Sbjct: 601 AYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Score = 63.5 bits (153), Expect = 4e-10
Identities = 45/119 (37%), Positives = 55/119 (46%), Gaps = 8/119 (6%)
Query: 208 ESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAA 267
E++ TPLH A+G + V L L H DV +T+ G T L A A + P C
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIA-AQDQQPDLC------- 411
Query: 268 RRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LL GADA PLH A NG G A LLL +GA + G TP+ A Q
Sbjct: 412 ALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQ 470
Score = 47.0 bits (110), Expect = 4e-05
Identities = 39/119 (32%), Positives = 58/119 (48%), Gaps = 3/119 (2%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A G L++ GA+ +A G LH A R+ F V LL A +
Sbjct: 629 PLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLE 231
+ G TP HL + + K+L+EAGA +++ G S TPL + A R +Q + +LE
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSC-TPLQL-ALRSRKQGIMSFLE 745
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 99.8 bits (247), Expect = 5e-21
Identities = 85/279 (30%), Positives = 118/279 (42%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQ---DEEAANMIVETVSNQLAWSAE---------QGFWVLTPK 108
+H A F G++ V L N+ ET + A S + G V
Sbjct: 437 IHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496
Query: 109 TKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGA 167
PL I+ G D + L++QGA +A G LH + D LL GA
Sbjct: 497 KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
++ T++G TPLH+ L+ A LLL+ A+ + AAG+S TPLHVAA ++
Sbjct: 557 SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD-AAGKSGLTPLHVAAHYDNQKVAL 615
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L L+ GA G T L+ A + A LLE GADA A R+
Sbjct: 616 LLLDQGASPHAAAKNGYTPLHIAAK--------KNQMDIATTLLEYGADANAVTRQGIAS 667
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
+H A G + LLL A + N +G TP+ A Q
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQ 706
Score = 95.5 bits (236), Expect = 9e-20
Identities = 75/236 (31%), Positives = 106/236 (44%), Gaps = 17/236 (7%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
P+ +A G+ + L+ GA + V G ALH A Q + VR L+ GA+
Sbjct: 436 PIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
++ TPLH+ + LL+ GA+ N AA S TPLH++A G E A L+H
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPN-AATTSGYTPLHLSAREGHEDVAAFLLDH 554
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GA + + T +G T L+ A + A LL+ A AAG+ TPLH A
Sbjct: 555 GASLSITTKKGFTPLHVAAKYGK--------LEVANLLLQKSASPDAAGKSGLTPLHVAA 606
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
+A LLL GA G+TP+ A + Q + LL+YGA
Sbjct: 607 HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD-------IATTLLEYGA 655
Score = 87.8 bits (216), Expect = 2e-17
Identities = 83/307 (27%), Positives = 122/307 (39%), Gaps = 39/307 (12%)
Query: 58 DPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSA------------EQGFWVL 105
+ A+H A SG + V+ L QD + L SA +QG
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 106 TPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLT 164
T PL ++ G+ D A L+ GA L G LH A + + LLL
Sbjct: 527 AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ 586
Query: 165 FGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQ 224
A + + G TPLH+ ++ + A LLL+ GA+ + AA ++ TPLH+AA +
Sbjct: 587 KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH-AAAKNGYTPLHIAAKKNQMD 645
Query: 225 HVALYLEHGADVGLRTSQGETALNTACAG------------------AEGPGSCRRHQAA 266
LE+GAD T QG +++ A + G H AA
Sbjct: 646 IATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705
Query: 267 -------ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHT 319
A L+ GA A + +TPLH C G + LL++ A+ G+T
Sbjct: 706 QEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYT 765
Query: 320 PMDCALQ 326
P+ A Q
Sbjct: 766 PLHQAAQ 772
Score = 83.6 bits (205), Expect = 3e-16
Identities = 63/212 (29%), Positives = 97/212 (45%), Gaps = 12/212 (5%)
Query: 115 LAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A G+ A+ L+ + A +A+ + G LH AC + + + LLL GA +T
Sbjct: 371 LHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHG 233
E G TP+H+ + L+ GA+ N ET LH+AA G + V ++ G
Sbjct: 431 ESGLTPIHVAAFMGHVNIVSQLMHHGASPN-TTNVRGETALHMAARSGQAEVVRYLVQDG 489
Query: 234 ADVGLRTSQGETALNTACAGAEGPGSCRRHQA-AARRLLEAGADARAAGRKRHTPLHNAC 292
A V + +T L+ S R +A ++LL+ GA AA +TPLH +
Sbjct: 490 AQVEAKAKDDQTPLHI---------SARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA 540
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G +A LL +GA + G TP+ A
Sbjct: 541 REGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572
Score = 82.8 bits (203), Expect = 6e-16
Identities = 72/235 (30%), Positives = 105/235 (44%), Gaps = 23/235 (9%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A+ G+ + L+++ A +DA G ALH A Q + V++L+T GA N +
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH- 232
+ G TPL++ L+ K LL+ GA+ +LA E TPL VA +G +Q V+L LE+
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLAT-EDGFTPLAVALQQGHDQVVSLLLEND 196
Query: 233 --------GADVGLRTSQGETAL----NTACAGAEG-PGSCRRHQAA-------ARRLLE 272
+ R + A N A E G H AA A LL
Sbjct: 197 TKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 273 AGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQA 327
A R TPLH A G + +LLL GA+ + G TP+ C ++
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARS 311
Score = 82.4 bits (202), Expect = 8e-16
Identities = 89/309 (28%), Positives = 131/309 (42%), Gaps = 42/309 (13%)
Query: 57 RDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLA 116
R PA+H A + + L Q++ A++ ++ GF PL
Sbjct: 202 RLPALHIAARKDDTKAAALLLQNDNNADV-----------ESKSGF----------TPLH 240
Query: 117 IATARGYTDCARHLIRQGAELDARVGGRAA-LHEACARAQFDCVRLLLTFGAKANVLTEE 175
IA G + A L+ + A +D LH A R + V+LLL GAK + T +
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300
Query: 176 GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGAD 235
G TPLH Q ++LL+ A + L+ ++ +PLH+A V L L+H
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDRAAPI-LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359
Query: 236 VGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANG 295
V T+ TAL+ A C H A+ LL+ A+ A TPLH AC
Sbjct: 360 VDDVTNDYLTALHVA-------AHC-GHYKVAKVLLDKKANPNAKALNGFTPLHIACKKN 411
Query: 296 CGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQP----V 351
+ ELLL++GA + +G TP+ A A N + + L+ +GA P V
Sbjct: 412 RIKVMELLLKHGASIQAVTESGLTPIHVA--AFMGHVN-----IVSQLMHHGASPNTTNV 464
Query: 352 RPEMLKHCA 360
R E H A
Sbjct: 465 RGETALHMA 473
Score = 77.4 bits (189), Expect = 2e-14
Identities = 61/217 (28%), Positives = 95/217 (43%), Gaps = 10/217 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A+ RG + + L+ +GA++DA+ G LH V +LL A
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSK 330
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
T+ G +PLH+ T + L C +LLL+ V+ + T LHVAA G + + L+
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYL-TALHVAAHCGHYKVAKVLLDK 389
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
A+ + G T L+ AC + LL+ GA +A TP+H A
Sbjct: 390 KANPNAKALNGFTPLHIACK--------KNRIKVMELLLKHGASIQAVTESGLTPIHVAA 441
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQ 329
G + L+ +GA N G T + A ++ Q
Sbjct: 442 FMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQ 478
Score = 75.9 bits (185), Expect = 7e-14
Identities = 63/212 (29%), Positives = 87/212 (41%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A A L+ QGA A G LH A + Q D LL +GA AN +
Sbjct: 601 PLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAV 660
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
T +G +HL + LLL A VNL + +S TPLH+AA + +
Sbjct: 661 TRQGIASVHLAAQEGHVDMVSLLLGRNANVNL-SNKSGLTPLHLAAQEDRVNVAEVLVNQ 719
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GA V +T G T L+ C + LL+ A A + +TPLH A
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYG--------NIKIVNFLLQHSAKVNAKTKNGYTPLHQAA 771
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + +LL+ A G+T + A
Sbjct: 772 QQGHTHIINVLLQNNASPNELTVNGNTALGIA 803
Score = 68.9 bits (167), Expect = 9e-12
Identities = 62/218 (28%), Positives = 93/218 (42%), Gaps = 14/218 (6%)
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFG 166
K+ A A G+ + A I+ G +++ G ALH A + V LL
Sbjct: 38 KSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
Query: 167 AKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHV 226
A + T++G T LH+ ++ + K+L+ GA VN A ++ TPL++AA + V
Sbjct: 98 ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN-AQSQNGFTPLYMAAQENHLEVV 156
Query: 227 ALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHT 286
L++GA L T G T L A + H LLE G+ R
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQ--------QGHDQVVSLLLEND----TKGKVRLP 204
Query: 287 PLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
LH A A LLL+ A+V + +G TP+ A
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIA 242
Score = 44.3 bits (103), Expect = 2e-04
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 9/135 (6%)
Query: 196 LEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAE 255
++ G +N+ ++ LH+A+ G + V+ L+ A+V T +G TAL+ A +
Sbjct: 61 IKNGVDINIC-NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQ 119
Query: 256 GPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNG 315
+ L+ GA+ A + TPL+ A + + LL GA +
Sbjct: 120 AE--------VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATE 171
Query: 316 AGHTPMDCALQAVQD 330
G TP+ ALQ D
Sbjct: 172 DGFTPLAVALQQGHD 186
Score = 42.4 bits (98), Expect = 9e-04
Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 9/120 (7%)
Query: 208 ESQETPLHVAAARGLEQHVAL-YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAA 266
+S ++ AAR AL Y+++G D+ + G AL+ A S H
Sbjct: 38 KSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLA--------SKEGHVEV 89
Query: 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LL+ A+ AA +K +T LH A G + ++L+ GA + G TP+ A Q
Sbjct: 90 VSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQ 149
>gi|121582655 ankyrin repeat domain 35 [Homo sapiens]
Length = 1001
Score = 98.2 bits (243), Expect = 1e-20
Identities = 65/192 (33%), Positives = 93/192 (48%), Gaps = 10/192 (5%)
Query: 143 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV 202
G++ H A ++ +C+ +LL GA N E+G+T LHL TI QC K+LL+ GA
Sbjct: 54 GQSPFHLAASKGLTECLTILLANGADINSKNEDGSTALHLATISCQPQCVKVLLQHGANE 113
Query: 203 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR 262
+ E++ +PLH AA+ G V L +H A + + + G T L A G
Sbjct: 114 DAVDAENR-SPLHWAASSGCASSVLLLCDHEAFLDVLDNDGRTPLMIASLGG-------- 164
Query: 263 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMD 322
H A +LL+ GA + + L AC G +AELLL +GA A + GH +
Sbjct: 165 HAAICSQLLQRGARVNVTDKNDKSALILACEKGSAEVAELLLSHGADAGAVDSTGHDALH 224
Query: 323 CALQAVQDSPNW 334
AL QD W
Sbjct: 225 YALH-TQDKALW 235
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 97.4 bits (241), Expect = 2e-20
Identities = 90/317 (28%), Positives = 135/317 (42%), Gaps = 29/317 (9%)
Query: 46 RARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVL 105
RA T + ++ +A G++ V+ L + + N E + L + G++ L
Sbjct: 223 RAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL 282
Query: 106 TPKTK-------------QTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEAC 151
PL A G+ + L+ A+++A+ G AL AC
Sbjct: 283 AQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYAC 342
Query: 152 ARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQE 211
A D V++LL GA E G TPL ++ A+LLLE GA +N + E +E
Sbjct: 343 AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 402
Query: 212 TPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLL 271
+ L +A +G + V LE GAD +T + TAL AC H AR LL
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG--------HVEVARLLL 454
Query: 272 EAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDS 331
++GA +PL A G LA LL+ GA E N G+TP+ ++A ++
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL---MEAAREG 511
Query: 332 PNWEPEVLFAALLDYGA 348
E + A LL GA
Sbjct: 512 ----HEEMVALLLGQGA 524
Score = 82.0 bits (201), Expect = 1e-15
Identities = 67/186 (36%), Positives = 84/186 (45%), Gaps = 10/186 (5%)
Query: 125 DCARHLIRQGAELDARVG--GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHL 182
+ A L R AE A G +L EAC+ + VR LL G N TEEG + L L
Sbjct: 214 EAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCL 273
Query: 183 CTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQ 242
+ A++LL A V + TPL AA G + V L L H ADV ++S
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 243 GETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAEL 302
G TAL ACAG + + LLE+GA HTPL A + G +A L
Sbjct: 334 GNTALTYACAGG--------YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385
Query: 303 LLRYGA 308
LL GA
Sbjct: 386 LLENGA 391
Score = 80.5 bits (197), Expect = 3e-15
Identities = 89/292 (30%), Positives = 120/292 (41%), Gaps = 44/292 (15%)
Query: 57 RDPAVHQALFSGNLQQVQALFQ---DEEAANMIVETVSNQLAWSA---------EQGFWV 104
++ A+ A + G+L+ V+ L + D+E + T + + G V
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Query: 105 LTPKTKQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLL 163
P +PL +A G+ + A LI +GA L+ G L EA + V LLL
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Query: 164 TFGAKANVLTEEGT-TPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
GA N TEE T L L L+ A L++AGA + L TPL AA G
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQEGH 576
Query: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-------------AGA----EGPGSCRRHQA 265
+ V L GA+V T+ G+TAL AC AGA E G
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 266 AARR--------LLEAGADA-RAAGRKRHTPLHNACANGCGGLAELLLRYGA 308
AAR L+ GA+ R HT L ACA G + ELLL +GA
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 77.4 bits (189), Expect = 2e-14
Identities = 67/219 (30%), Positives = 101/219 (46%), Gaps = 14/219 (6%)
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFG 166
+TK T PL++A + G + L+ +GA + R V L A + + +++LL G
Sbjct: 1148 RTKDT-PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 1206
Query: 167 AKANVLTEE--GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQ 224
A+ N T G +PL L + KLLL+ G+ +N ++ T L +A +G +
Sbjct: 1207 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1266
Query: 225 HVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARA--AGR 282
V+L L+ A+V R G T L A +G + R LL+ GAD A
Sbjct: 1267 VVSLLLDRKANVEHRAKTGLTPLMEAASGG--------YAEVGRVLLDKGADVNAPPVPS 1318
Query: 283 KRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPM 321
R T L A G ELL+ GA +V N G+TP+
Sbjct: 1319 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPL 1357
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/247 (28%), Positives = 102/247 (41%), Gaps = 45/247 (18%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVGG-RAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A +G+ + R L+ GA+ + + AL EAC + RLLL GA+ N+
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEA---------------------------------GA 200
+ +PL L ++ A LL+E GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 201 TVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
+N E+QET L +A G + ++ GAD+ L S T L A EG
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME--AAQEG---- 575
Query: 261 RRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
H + LL AGA+ A T L AC NG +A++LL+ GA E + G TP
Sbjct: 576 --HLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
Query: 321 MDCALQA 327
+ A +A
Sbjct: 634 LMKAARA 640
Score = 73.2 bits (178), Expect = 5e-13
Identities = 55/186 (29%), Positives = 88/186 (47%), Gaps = 11/186 (5%)
Query: 113 APLAIATARGYTDCARHLIRQGAELDARV--GGRAALHEACARAQFDCVRLLLTFGAKAN 170
+PL +A G+T + L+ G++++A++ AL AC + + + V LLL A
Sbjct: 1220 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1279
Query: 171 VLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA-AGESQETPLHVAAARGLEQHVALY 229
+ G TPL + ++LL+ GA VN S++T L +AA +G + L
Sbjct: 1280 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339
Query: 230 LEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLH 289
+ GA + +R +G T L A G H + L++AGAD AA ++ TPL
Sbjct: 1340 IGRGAHIDVRNKKGNTPLWLAANGG--------HLDVVQLLVQAGADVDAADNRKITPLM 1391
Query: 290 NACANG 295
A G
Sbjct: 1392 AAFRKG 1397
Score = 65.9 bits (159), Expect = 7e-11
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 15/219 (6%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVG---GRAALHEACARAQFDCVRLLLTFGAKAN 170
PL++A + GY + + L+ GAE+++R G G + L A V+LLL G+ N
Sbjct: 1186 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 1245
Query: 171 VLTEEG-TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALY 229
E T L L + LLL+ A V A ++ TPL AA+ G + +
Sbjct: 1246 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1304
Query: 230 LEHGADVGLRT--SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L+ GADV S +TAL A + H L+ GA +K +TP
Sbjct: 1305 LDKGADVNAPPVPSSRDTALTIAAD--------KGHYKFCELLIGRGAHIDVRNKKGNTP 1356
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
L A G + +LL++ GA + + TP+ A +
Sbjct: 1357 LWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFR 1395
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/157 (31%), Positives = 65/157 (41%), Gaps = 15/157 (9%)
Query: 112 TAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKAN 170
+ PL A G+ + ++L+ GA + A G AL AC D +LL GA
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 171 VLTEEGTTPL-------HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLE 223
+E G TPL H+CT+ + L+ GA VN + T L +A A G
Sbjct: 625 HESEGGRTPLMKAARAGHVCTV-------QFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 224 QHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
V L L HGAD R G T L A G C
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Score = 61.2 bits (147), Expect = 2e-09
Identities = 60/204 (29%), Positives = 86/204 (42%), Gaps = 28/204 (13%)
Query: 146 ALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA 205
AL ACA + V+ LL GA ++G TPL L + ++LL+ GA +
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 1145
Query: 206 AGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-------------A 252
+ +++TPL +A + G ++ V L L GA+ R T L+ A A
Sbjct: 1146 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1205
Query: 253 GAE-----------GP---GSCRRHQAAARRLLEAGADARA-AGRKRHTPLHNACANGCG 297
GAE P + H AA + LL+ G+D A R+T L AC G
Sbjct: 1206 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1265
Query: 298 GLAELLLRYGARAEVPNGAGHTPM 321
+ LLL A E G TP+
Sbjct: 1266 EVVSLLLDRKANVEHRAKTGLTPL 1289
Score = 55.5 bits (132), Expect = 1e-07
Identities = 43/134 (32%), Positives = 59/134 (44%), Gaps = 9/134 (6%)
Query: 192 AKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC 251
A L + ++ + +T L +A A G E+ V LE GA + R +G T L A
Sbjct: 1065 AMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 1124
Query: 252 AGAEGPGSCRRHQAAARRLLEAGADARAAG-RKRHTPLHNACANGCGGLAELLLRYGARA 310
H LL+ GAD A R + TPL AC+ G + ELLL GA
Sbjct: 1125 TAG--------HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANK 1176
Query: 311 EVPNGAGHTPMDCA 324
E N + +TP+ A
Sbjct: 1177 EHRNVSDYTPLSLA 1190
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 97.4 bits (241), Expect = 2e-20
Identities = 90/317 (28%), Positives = 135/317 (42%), Gaps = 29/317 (9%)
Query: 46 RARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVL 105
RA T + ++ +A G++ V+ L + + N E + L + G++ L
Sbjct: 223 RAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL 282
Query: 106 TPKTK-------------QTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEAC 151
PL A G+ + L+ A+++A+ G AL AC
Sbjct: 283 AQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYAC 342
Query: 152 ARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQE 211
A D V++LL GA E G TPL ++ A+LLLE GA +N + E +E
Sbjct: 343 AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE 402
Query: 212 TPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLL 271
+ L +A +G + V LE GAD +T + TAL AC H AR LL
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG--------HVEVARLLL 454
Query: 272 EAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDS 331
++GA +PL A G LA LL+ GA E N G+TP+ ++A ++
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL---MEAAREG 511
Query: 332 PNWEPEVLFAALLDYGA 348
E + A LL GA
Sbjct: 512 ----HEEMVALLLGQGA 524
Score = 82.0 bits (201), Expect = 1e-15
Identities = 67/186 (36%), Positives = 84/186 (45%), Gaps = 10/186 (5%)
Query: 125 DCARHLIRQGAELDARVG--GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHL 182
+ A L R AE A G +L EAC+ + VR LL G N TEEG + L L
Sbjct: 214 EAAAALTRMRAESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCL 273
Query: 183 CTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQ 242
+ A++LL A V + TPL AA G + V L L H ADV ++S
Sbjct: 274 ACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSST 333
Query: 243 GETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAEL 302
G TAL ACAG + + LLE+GA HTPL A + G +A L
Sbjct: 334 GNTALTYACAGG--------YVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385
Query: 303 LLRYGA 308
LL GA
Sbjct: 386 LLENGA 391
Score = 80.5 bits (197), Expect = 3e-15
Identities = 89/292 (30%), Positives = 120/292 (41%), Gaps = 44/292 (15%)
Query: 57 RDPAVHQALFSGNLQQVQALFQ---DEEAANMIVETVSNQLAWSA---------EQGFWV 104
++ A+ A + G+L+ V+ L + D+E + T + + G V
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQV 460
Query: 105 LTPKTKQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLL 163
P +PL +A G+ + A LI +GA L+ G L EA + V LLL
Sbjct: 461 NMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLL 520
Query: 164 TFGAKANVLTEEGT-TPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
GA N TEE T L L L+ A L++AGA + L TPL AA G
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQEGH 576
Query: 223 EQHVALYLEHGADVGLRTSQGETALNTAC-------------AGA----EGPGSCRRHQA 265
+ V L GA+V T+ G+TAL AC AGA E G
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 266 AARR--------LLEAGADA-RAAGRKRHTPLHNACANGCGGLAELLLRYGA 308
AAR L+ GA+ R HT L ACA G + ELLL +GA
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGA 688
Score = 77.4 bits (189), Expect = 2e-14
Identities = 67/219 (30%), Positives = 101/219 (46%), Gaps = 14/219 (6%)
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFG 166
+TK T PL++A + G + L+ +GA + R V L A + + +++LL G
Sbjct: 897 RTKDT-PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAG 955
Query: 167 AKANVLTEE--GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQ 224
A+ N T G +PL L + KLLL+ G+ +N ++ T L +A +G +
Sbjct: 956 AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTE 1015
Query: 225 HVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARA--AGR 282
V+L L+ A+V R G T L A +G + R LL+ GAD A
Sbjct: 1016 VVSLLLDRKANVEHRAKTGLTPLMEAASGG--------YAEVGRVLLDKGADVNAPPVPS 1067
Query: 283 KRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPM 321
R T L A G ELL+ GA +V N G+TP+
Sbjct: 1068 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPL 1106
Score = 73.9 bits (180), Expect = 3e-13
Identities = 70/247 (28%), Positives = 102/247 (41%), Gaps = 45/247 (18%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVGG-RAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A +G+ + R L+ GA+ + + AL EAC + RLLL GA+ N+
Sbjct: 405 LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA 464
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEA---------------------------------GA 200
+ +PL L ++ A LL+E GA
Sbjct: 465 DSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGA 524
Query: 201 TVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
+N E+QET L +A G + ++ GAD+ L S T L A EG
Sbjct: 525 NINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLME--AAQEG---- 575
Query: 261 RRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
H + LL AGA+ A T L AC NG +A++LL+ GA E + G TP
Sbjct: 576 --HLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTP 633
Query: 321 MDCALQA 327
+ A +A
Sbjct: 634 LMKAARA 640
Score = 73.2 bits (178), Expect = 5e-13
Identities = 55/186 (29%), Positives = 88/186 (47%), Gaps = 11/186 (5%)
Query: 113 APLAIATARGYTDCARHLIRQGAELDARV--GGRAALHEACARAQFDCVRLLLTFGAKAN 170
+PL +A G+T + L+ G++++A++ AL AC + + + V LLL A
Sbjct: 969 SPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVE 1028
Query: 171 VLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA-AGESQETPLHVAAARGLEQHVALY 229
+ G TPL + ++LL+ GA VN S++T L +AA +G + L
Sbjct: 1029 HRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088
Query: 230 LEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLH 289
+ GA + +R +G T L A G H + L++AGAD AA ++ TPL
Sbjct: 1089 IGRGAHIDVRNKKGNTPLWLAANGG--------HLDVVQLLVQAGADVDAADNRKITPLM 1140
Query: 290 NACANG 295
A G
Sbjct: 1141 AAFRKG 1146
Score = 65.9 bits (159), Expect = 7e-11
Identities = 63/219 (28%), Positives = 96/219 (43%), Gaps = 15/219 (6%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVG---GRAALHEACARAQFDCVRLLLTFGAKAN 170
PL++A + GY + + L+ GAE+++R G G + L A V+LLL G+ N
Sbjct: 935 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDIN 994
Query: 171 VLTEEG-TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALY 229
E T L L + LLL+ A V A ++ TPL AA+ G + +
Sbjct: 995 AQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAEVGRVL 1053
Query: 230 LEHGADVGLRT--SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L+ GADV S +TAL A + H L+ GA +K +TP
Sbjct: 1054 LDKGADVNAPPVPSSRDTALTIAAD--------KGHYKFCELLIGRGAHIDVRNKKGNTP 1105
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
L A G + +LL++ GA + + TP+ A +
Sbjct: 1106 LWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFR 1144
Score = 64.7 bits (156), Expect = 2e-10
Identities = 50/157 (31%), Positives = 65/157 (41%), Gaps = 15/157 (9%)
Query: 112 TAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKAN 170
+ PL A G+ + ++L+ GA + A G AL AC D +LL GA
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLE 624
Query: 171 VLTEEGTTPL-------HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLE 223
+E G TPL H+CT+ + L+ GA VN + T L +A A G
Sbjct: 625 HESEGGRTPLMKAARAGHVCTV-------QFLISKGANVNRTTANNDHTVLSLACAGGHL 677
Query: 224 QHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
V L L HGAD R G T L A G C
Sbjct: 678 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVC 714
Score = 61.2 bits (147), Expect = 2e-09
Identities = 60/204 (29%), Positives = 86/204 (42%), Gaps = 28/204 (13%)
Query: 146 ALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLA 205
AL ACA + V+ LL GA ++G TPL L + ++LL+ GA +
Sbjct: 835 ALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQ 894
Query: 206 AGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-------------A 252
+ +++TPL +A + G ++ V L L GA+ R T L+ A A
Sbjct: 895 SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 954
Query: 253 GAE-----------GP---GSCRRHQAAARRLLEAGADARA-AGRKRHTPLHNACANGCG 297
GAE P + H AA + LL+ G+D A R+T L AC G
Sbjct: 955 GAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRT 1014
Query: 298 GLAELLLRYGARAEVPNGAGHTPM 321
+ LLL A E G TP+
Sbjct: 1015 EVVSLLLDRKANVEHRAKTGLTPL 1038
Score = 55.5 bits (132), Expect = 1e-07
Identities = 43/134 (32%), Positives = 59/134 (44%), Gaps = 9/134 (6%)
Query: 192 AKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC 251
A L + ++ + +T L +A A G E+ V LE GA + R +G T L A
Sbjct: 814 AMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAA 873
Query: 252 AGAEGPGSCRRHQAAARRLLEAGADARAAG-RKRHTPLHNACANGCGGLAELLLRYGARA 310
H LL+ GAD A R + TPL AC+ G + ELLL GA
Sbjct: 874 TAG--------HVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANK 925
Query: 311 EVPNGAGHTPMDCA 324
E N + +TP+ A
Sbjct: 926 EHRNVSDYTPLSLA 939
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 96.7 bits (239), Expect = 4e-20
Identities = 85/279 (30%), Positives = 123/279 (44%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQD---EEAANMIVETVSNQLAWSAE---------QGFWVLTPK 108
+H A F G+L V L Q+ + N+ ET + A + + G V
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
Query: 109 TKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGA 167
++ PL IA+ G T+ + L++ A DA G LH + Q D +LL GA
Sbjct: 474 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 533
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
++ T++G TPLH+ SL AKLLL+ A + +AG++ TPLHVAA ++
Sbjct: 534 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVAL 592
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L LE GA G T L+ A + A LL GA+ ++ TP
Sbjct: 593 LLLEKGASPHATAKNGYTPLHIAAK--------KNQMQIASTLLNYGAETNIVTKQGVTP 644
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL GA + +G T + A Q
Sbjct: 645 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 683
Score = 93.2 bits (230), Expect = 4e-19
Identities = 97/318 (30%), Positives = 139/318 (43%), Gaps = 34/318 (10%)
Query: 57 RDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLA 116
R PA+H A + + L Q++ A++ + + N+ + E GF PL
Sbjct: 171 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR---TTESGF----------TPLH 217
Query: 117 IATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVLTEE 175
IA G + A L+ +GA +D G LH A R + V+LLL G + + T +
Sbjct: 218 IAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 277
Query: 176 GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGAD 235
G TPLH Q +LLLE GA + LA ++ +PLH+AA + V L+H A
Sbjct: 278 GLTPLHCAARSGHDQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336
Query: 236 VGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANG 295
V T TAL+ A C H + LL+ A+ A TPLH AC
Sbjct: 337 VDDVTLDYLTALHVA-------AHC-GHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 388
Query: 296 CGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQP----V 351
+ ELL++YGA + +G TP+ A A N + LL GA P +
Sbjct: 389 RIKVMELLVKYGASIQAITESGLTPIHVA--AFMGHLN-----IVLLLLQNGASPDVTNI 441
Query: 352 RPEMLKHCANFPRALEVL 369
R E H A +EV+
Sbjct: 442 RGETALHMAARAGQVEVV 459
Score = 90.1 bits (222), Expect = 4e-18
Identities = 64/212 (30%), Positives = 96/212 (45%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A A L+ +GA A G LH A + Q LL +GA+ N++
Sbjct: 578 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 637
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
T++G TPLHL + LLL+ GA ++++ +S T LH+AA + +H
Sbjct: 638 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKH 696
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GAD T G T L AC + LL+ GA+ A + +TPLH A
Sbjct: 697 GADQDAHTKLGYTPLIVACHYG--------NVKMVNFLLKQGANVNAKTKNGYTPLHQAA 748
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + +LL++GA+ G+T + A
Sbjct: 749 QQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Score = 89.0 bits (219), Expect = 8e-18
Identities = 74/242 (30%), Positives = 104/242 (42%), Gaps = 17/242 (7%)
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGAK 168
K PL +A G D A+ L+++ A D A G LH A LLL GA
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 169 ANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228
+ + G TPLH+ +Q A LL GA N+ + TPLH+A+ G V L
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTL 659
Query: 229 YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPL 288
L+ GA++ + T G T+L+ A + A L + GAD A + +TPL
Sbjct: 660 LLDKGANIHMSTKSGLTSLHLAAQEDK--------VNVADILTKHGADQDAHTKLGYTPL 711
Query: 289 HNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
AC G + LL+ GA G+TP+ A Q + LL +GA
Sbjct: 712 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH-------IINVLLQHGA 764
Query: 349 QP 350
+P
Sbjct: 765 KP 766
Score = 86.7 bits (213), Expect = 4e-17
Identities = 74/237 (31%), Positives = 108/237 (45%), Gaps = 17/237 (7%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
P+ +A G+ + L++ GA D + G ALH A Q + VR LL GA +
Sbjct: 413 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 472
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
E TPLH+ + + +LLL+ A + AA + TPLH++A G ++ LE
Sbjct: 473 AREEQTPLHIASRLGKTEIVQLLLQHMAHPD-AATTNGYTPLHISAREGQVDVASVLLEA 531
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GA L T +G T L+ A A+ LL+ A A +AG+ TPLH A
Sbjct: 532 GAAHSLATKKGFTPLHVAAKYGS--------LDVAKLLLQRRAAADSAGKNGLTPLHVAA 583
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQ 349
+A LLL GA G+TP+ A + Q + + LL+YGA+
Sbjct: 584 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ-------IASTLLNYGAE 633
Score = 85.5 bits (210), Expect = 9e-17
Identities = 77/270 (28%), Positives = 116/270 (42%), Gaps = 50/270 (18%)
Query: 115 LAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A G+ + L+ + A +AR + G LH AC + + + LL+ +GA +T
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 407
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNL----------------------------- 204
E G TP+H+ L LLL+ GA+ ++
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Query: 205 ---AAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCR 261
A ++TPLH+A+ G + V L L+H A T+ G T L+ S R
Sbjct: 468 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI---------SAR 518
Query: 262 RHQA-AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
Q A LLEAGA A +K TPLH A G +A+LLL+ A A+ G TP
Sbjct: 519 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 578
Query: 321 MDCALQAVQDSPNWEPEVLFAALLDYGAQP 350
+ A +++ + + LL+ GA P
Sbjct: 579 LHVA-------AHYDNQKVALLLLEKGASP 601
Score = 77.8 bits (190), Expect = 2e-14
Identities = 71/251 (28%), Positives = 99/251 (39%), Gaps = 41/251 (16%)
Query: 115 LAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A G+ + L+ +G+ +D A G ALH A Q + V++L+ GA N +
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLE-- 231
+ G TPL++ + K LLE GA + A E TPL VA +G Q VA+ LE
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGANQSTAT-EDGFTPLAVALQQGHNQAVAILLEND 165
Query: 232 -----------------------------HGADVGLRTSQGETALNTACAGAEGPGSCRR 262
H ADV Q + +N P
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADV-----QSKMMVNRTTESGFTPLHIAA 220
Query: 263 HQA---AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHT 319
H A LL GA R TPLH A G + +LLL G + + G T
Sbjct: 221 HYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 280
Query: 320 PMDCALQAVQD 330
P+ CA ++ D
Sbjct: 281 PLHCAARSGHD 291
Score = 60.1 bits (144), Expect = 4e-09
Identities = 62/247 (25%), Positives = 96/247 (38%), Gaps = 31/247 (12%)
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFG 166
K+ A A G D ++ G +++ G ALH A V+ LL G
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG 66
Query: 167 AKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHV 226
+ + T++G T LH+ ++ + K+L++ GA +N A ++ TPL++AA V
Sbjct: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANIN-AQSQNGFTPLYMAAQENHIDVV 125
Query: 227 ALYLEHGADVGLRTSQGETALNTACAGAEGPG--------------------SCRRHQAA 266
LE+GA+ T G T L A + R+
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
Query: 267 ARRLL---EAGADARA------AGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAG 317
+ LL + AD ++ TPLH A G +A LLL GA + G
Sbjct: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 245
Query: 318 HTPMDCA 324
TP+ A
Sbjct: 246 ITPLHVA 252
Score = 43.9 bits (102), Expect = 3e-04
Identities = 37/126 (29%), Positives = 56/126 (44%), Gaps = 9/126 (7%)
Query: 201 TVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSC 260
T L +S + L A A L++ V YL+ G D+ G AL+ A EG
Sbjct: 2 TTMLQKSDSNASFLRAARAGNLDK-VVEYLKGGIDINTCNQNGLNALHLAAK--EG---- 54
Query: 261 RRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
H + LL G+ +A +K +T LH A G + ++L++ GA + G TP
Sbjct: 55 --HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTP 112
Query: 321 MDCALQ 326
+ A Q
Sbjct: 113 LYMAAQ 118
Score = 43.9 bits (102), Expect = 3e-04
Identities = 36/131 (27%), Positives = 54/131 (41%), Gaps = 9/131 (6%)
Query: 196 LEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAE 255
L+ G +N ++ LH+AA G V L G+ V T +G TAL+ A +
Sbjct: 30 LKGGIDIN-TCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQ 88
Query: 256 GPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNG 315
+ L++ GA+ A + TPL+ A + + LL GA
Sbjct: 89 AE--------VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATE 140
Query: 316 AGHTPMDCALQ 326
G TP+ ALQ
Sbjct: 141 DGFTPLAVALQ 151
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 96.7 bits (239), Expect = 4e-20
Identities = 85/279 (30%), Positives = 123/279 (44%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQD---EEAANMIVETVSNQLAWSAE---------QGFWVLTPK 108
+H A F G+L V L Q+ + N+ ET + A + + G V
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 109 TKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGA 167
++ PL IA+ G T+ + L++ A DA G LH + Q D +LL GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
++ T++G TPLH+ SL AKLLL+ A + +AG++ TPLHVAA ++
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVAL 613
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L LE GA G T L+ A + A LL GA+ ++ TP
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAK--------KNQMQIASTLLNYGAETNIVTKQGVTP 665
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL GA + +G T + A Q
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Score = 93.2 bits (230), Expect = 4e-19
Identities = 97/318 (30%), Positives = 139/318 (43%), Gaps = 34/318 (10%)
Query: 57 RDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLA 116
R PA+H A + + L Q++ A++ + + N+ + E GF PL
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR---TTESGF----------TPLH 238
Query: 117 IATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVLTEE 175
IA G + A L+ +GA +D G LH A R + V+LLL G + + T +
Sbjct: 239 IAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 176 GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGAD 235
G TPLH Q +LLLE GA + LA ++ +PLH+AA + V L+H A
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 236 VGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANG 295
V T TAL+ A C H + LL+ A+ A TPLH AC
Sbjct: 358 VDDVTLDYLTALHVA-------AHC-GHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Query: 296 CGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQP----V 351
+ ELL++YGA + +G TP+ A A N + LL GA P +
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVA--AFMGHLN-----IVLLLLQNGASPDVTNI 462
Query: 352 RPEMLKHCANFPRALEVL 369
R E H A +EV+
Sbjct: 463 RGETALHMAARAGQVEVV 480
Score = 90.1 bits (222), Expect = 4e-18
Identities = 64/212 (30%), Positives = 96/212 (45%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A A L+ +GA A G LH A + Q LL +GA+ N++
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
T++G TPLHL + LLL+ GA ++++ +S T LH+AA + +H
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKH 717
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GAD T G T L AC + LL+ GA+ A + +TPLH A
Sbjct: 718 GADQDAHTKLGYTPLIVACHYG--------NVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + +LL++GA+ G+T + A
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 89.0 bits (219), Expect = 8e-18
Identities = 74/242 (30%), Positives = 104/242 (42%), Gaps = 17/242 (7%)
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGAK 168
K PL +A G D A+ L+++ A D A G LH A LLL GA
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 169 ANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228
+ + G TPLH+ +Q A LL GA N+ + TPLH+A+ G V L
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTL 680
Query: 229 YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPL 288
L+ GA++ + T G T+L+ A + A L + GAD A + +TPL
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDK--------VNVADILTKHGADQDAHTKLGYTPL 732
Query: 289 HNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
AC G + LL+ GA G+TP+ A Q + LL +GA
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH-------IINVLLQHGA 785
Query: 349 QP 350
+P
Sbjct: 786 KP 787
Score = 86.7 bits (213), Expect = 4e-17
Identities = 74/237 (31%), Positives = 108/237 (45%), Gaps = 17/237 (7%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
P+ +A G+ + L++ GA D + G ALH A Q + VR LL GA +
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
E TPLH+ + + +LLL+ A + AA + TPLH++A G ++ LE
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPD-AATTNGYTPLHISAREGQVDVASVLLEA 552
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GA L T +G T L+ A A+ LL+ A A +AG+ TPLH A
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGS--------LDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQ 349
+A LLL GA G+TP+ A + Q + + LL+YGA+
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ-------IASTLLNYGAE 654
Score = 85.5 bits (210), Expect = 9e-17
Identities = 77/270 (28%), Positives = 116/270 (42%), Gaps = 50/270 (18%)
Query: 115 LAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A G+ + L+ + A +AR + G LH AC + + + LL+ +GA +T
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNL----------------------------- 204
E G TP+H+ L LLL+ GA+ ++
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 205 ---AAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCR 261
A ++TPLH+A+ G + V L L+H A T+ G T L+ S R
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI---------SAR 539
Query: 262 RHQA-AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
Q A LLEAGA A +K TPLH A G +A+LLL+ A A+ G TP
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Query: 321 MDCALQAVQDSPNWEPEVLFAALLDYGAQP 350
+ A +++ + + LL+ GA P
Sbjct: 600 LHVA-------AHYDNQKVALLLLEKGASP 622
Score = 78.2 bits (191), Expect = 1e-14
Identities = 88/334 (26%), Positives = 126/334 (37%), Gaps = 62/334 (18%)
Query: 32 AAQQCRSRRCPSSPRARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVS 91
AAQ+ S + R RP +S + + +A +GNL +V VE +
Sbjct: 6 AAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKV-------------VEYLK 52
Query: 92 NQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEA 150
G + T L +A G+ + L+ +G+ +D A G ALH A
Sbjct: 53 G--------GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 104
Query: 151 CARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQ 210
Q + V++L+ GA N ++ G TPL++ + K LLE GA + A E
Sbjct: 105 SLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT-EDG 163
Query: 211 ETPLHVAAARGLEQHVALYLE-------------------------------HGADVGLR 239
TPL VA +G Q VA+ LE H ADV
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV--- 220
Query: 240 TSQGETALNTACAGAEGPGSCRRHQA---AARRLLEAGADARAAGRKRHTPLHNACANGC 296
Q + +N P H A LL GA R TPLH A G
Sbjct: 221 --QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 297 GGLAELLLRYGARAEVPNGAGHTPMDCALQAVQD 330
+ +LLL G + + G TP+ CA ++ D
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 96.7 bits (239), Expect = 4e-20
Identities = 85/279 (30%), Positives = 123/279 (44%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQD---EEAANMIVETVSNQLAWSAE---------QGFWVLTPK 108
+H A F G+L V L Q+ + N+ ET + A + + G V
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 109 TKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGA 167
++ PL IA+ G T+ + L++ A DA G LH + Q D +LL GA
Sbjct: 495 REEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA 554
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
++ T++G TPLH+ SL AKLLL+ A + +AG++ TPLHVAA ++
Sbjct: 555 AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVAL 613
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L LE GA G T L+ A + A LL GA+ ++ TP
Sbjct: 614 LLLEKGASPHATAKNGYTPLHIAAK--------KNQMQIASTLLNYGAETNIVTKQGVTP 665
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL GA + +G T + A Q
Sbjct: 666 LHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQ 704
Score = 93.2 bits (230), Expect = 4e-19
Identities = 97/318 (30%), Positives = 139/318 (43%), Gaps = 34/318 (10%)
Query: 57 RDPAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLA 116
R PA+H A + + L Q++ A++ + + N+ + E GF PL
Sbjct: 192 RLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNR---TTESGF----------TPLH 238
Query: 117 IATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVLTEE 175
IA G + A L+ +GA +D G LH A R + V+LLL G + + T +
Sbjct: 239 IAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD 298
Query: 176 GTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGAD 235
G TPLH Q +LLLE GA + LA ++ +PLH+AA + V L+H A
Sbjct: 299 GLTPLHCAARSGHDQVVELLLERGAPL-LARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 236 VGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANG 295
V T TAL+ A C H + LL+ A+ A TPLH AC
Sbjct: 358 VDDVTLDYLTALHVA-------AHC-GHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Query: 296 CGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQP----V 351
+ ELL++YGA + +G TP+ A A N + LL GA P +
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVA--AFMGHLN-----IVLLLLQNGASPDVTNI 462
Query: 352 RPEMLKHCANFPRALEVL 369
R E H A +EV+
Sbjct: 463 RGETALHMAARAGQVEVV 480
Score = 90.1 bits (222), Expect = 4e-18
Identities = 64/212 (30%), Positives = 96/212 (45%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A A L+ +GA A G LH A + Q LL +GA+ N++
Sbjct: 599 PLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIV 658
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
T++G TPLHL + LLL+ GA ++++ +S T LH+AA + +H
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMST-KSGLTSLHLAAQEDKVNVADILTKH 717
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GAD T G T L AC + LL+ GA+ A + +TPLH A
Sbjct: 718 GADQDAHTKLGYTPLIVACHYG--------NVKMVNFLLKQGANVNAKTKNGYTPLHQAA 769
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + +LL++GA+ G+T + A
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 89.0 bits (219), Expect = 8e-18
Identities = 74/242 (30%), Positives = 104/242 (42%), Gaps = 17/242 (7%)
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGAK 168
K PL +A G D A+ L+++ A D A G LH A LLL GA
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 169 ANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVAL 228
+ + G TPLH+ +Q A LL GA N+ + TPLH+A+ G V L
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV-TPLHLASQEGHTDMVTL 680
Query: 229 YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPL 288
L+ GA++ + T G T+L+ A + A L + GAD A + +TPL
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDK--------VNVADILTKHGADQDAHTKLGYTPL 732
Query: 289 HNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
AC G + LL+ GA G+TP+ A Q + LL +GA
Sbjct: 733 IVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH-------IINVLLQHGA 785
Query: 349 QP 350
+P
Sbjct: 786 KP 787
Score = 86.7 bits (213), Expect = 4e-17
Identities = 74/237 (31%), Positives = 108/237 (45%), Gaps = 17/237 (7%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
P+ +A G+ + L++ GA D + G ALH A Q + VR LL GA +
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDAR 493
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
E TPLH+ + + +LLL+ A + AA + TPLH++A G ++ LE
Sbjct: 494 AREEQTPLHIASRLGKTEIVQLLLQHMAHPD-AATTNGYTPLHISAREGQVDVASVLLEA 552
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
GA L T +G T L+ A A+ LL+ A A +AG+ TPLH A
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGS--------LDVAKLLLQRRAAADSAGKNGLTPLHVAA 604
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQ 349
+A LLL GA G+TP+ A + Q + + LL+YGA+
Sbjct: 605 HYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ-------IASTLLNYGAE 654
Score = 85.5 bits (210), Expect = 9e-17
Identities = 77/270 (28%), Positives = 116/270 (42%), Gaps = 50/270 (18%)
Query: 115 LAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A G+ + L+ + A +AR + G LH AC + + + LL+ +GA +T
Sbjct: 369 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAIT 428
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNL----------------------------- 204
E G TP+H+ L LLL+ GA+ ++
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 205 ---AAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCR 261
A ++TPLH+A+ G + V L L+H A T+ G T L+ S R
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHI---------SAR 539
Query: 262 RHQA-AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTP 320
Q A LLEAGA A +K TPLH A G +A+LLL+ A A+ G TP
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Query: 321 MDCALQAVQDSPNWEPEVLFAALLDYGAQP 350
+ A +++ + + LL+ GA P
Sbjct: 600 LHVA-------AHYDNQKVALLLLEKGASP 622
Score = 78.2 bits (191), Expect = 1e-14
Identities = 88/334 (26%), Positives = 126/334 (37%), Gaps = 62/334 (18%)
Query: 32 AAQQCRSRRCPSSPRARLTRPHRSCRDPAVHQALFSGNLQQVQALFQDEEAANMIVETVS 91
AAQ+ S + R RP +S + + +A +GNL +V VE +
Sbjct: 6 AAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKV-------------VEYLK 52
Query: 92 NQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEA 150
G + T L +A G+ + L+ +G+ +D A G ALH A
Sbjct: 53 G--------GIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIA 104
Query: 151 CARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQ 210
Q + V++L+ GA N ++ G TPL++ + K LLE GA + A E
Sbjct: 105 SLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTAT-EDG 163
Query: 211 ETPLHVAAARGLEQHVALYLE-------------------------------HGADVGLR 239
TPL VA +G Q VA+ LE H ADV
Sbjct: 164 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV--- 220
Query: 240 TSQGETALNTACAGAEGPGSCRRHQA---AARRLLEAGADARAAGRKRHTPLHNACANGC 296
Q + +N P H A LL GA R TPLH A G
Sbjct: 221 --QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 297 GGLAELLLRYGARAEVPNGAGHTPMDCALQAVQD 330
+ +LLL G + + G TP+ CA ++ D
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312
>gi|13443014 ankyrin repeat and SOCS box-containing 9 isoform 2
[Homo sapiens]
Length = 262
Score = 94.4 bits (233), Expect = 2e-19
Identities = 65/211 (30%), Positives = 101/211 (47%), Gaps = 12/211 (5%)
Query: 113 APLAIATARGYTDCARHLIRQGAELDARVGGRAA-LHEACARAQFDCVRLLLTFGAKANV 171
+P+ A G+ R+LI QG ++ + LHEAC CV++LL GA+ N
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 172 LTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLE 231
+T + TPL + S C LLL+ GA+V +P+H AA RG + V +
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRGHVECVNSLIA 155
Query: 232 HGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNA 291
+G ++ + S T L AC + +A ++LLE+GAD G+ + +PLH
Sbjct: 156 YGGNIDHKISHLGTPLYLACE--------NQQRACVKKLLESGADVN-QGKGQDSPLHAV 206
Query: 292 CANGCGGLAELLLRYGARAEVPNGAGHTPMD 322
LA LL+ +GA + N G P++
Sbjct: 207 ARTASEELACLLMDFGADTQAKNAEGKRPVE 237
Score = 64.7 bits (156), Expect = 2e-10
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 35/178 (19%)
Query: 100 QGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAEL------------DARVGG---- 143
QG+ V +PL A G+ C + L++ GA++ +A V G
Sbjct: 58 QGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDC 117
Query: 144 -----------------RAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIP 186
+ +HEA R +CV L+ +G + TPL+L
Sbjct: 118 VNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACEN 177
Query: 187 ESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGE 244
+ C K LLE+GA VN G+ Q++PLH A E+ L ++ GAD + ++G+
Sbjct: 178 QQRACVKKLLESGADVN--QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
Score = 50.4 bits (119), Expect = 3e-06
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 8/103 (7%)
Query: 209 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAAR 268
S +P+H AA G + + + G V + T+ + L+ AC G H + +
Sbjct: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGG--------HLSCVK 86
Query: 269 RLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAE 311
LL+ GA HTPL NAC +G LLL++GA +
Sbjct: 87 ILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ 129
Score = 40.8 bits (94), Expect = 0.003
Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 2/84 (2%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
PL +A C + L+ GA+++ G + LH A + LL+ FGA
Sbjct: 170 PLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKN 229
Query: 174 EEGTTPLHLCTIPESLQCAKLLLE 197
EG P+ L +P A+L LE
Sbjct: 230 AEGKRPVEL--VPPESPLAQLFLE 251
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 94.4 bits (233), Expect = 2e-19
Identities = 65/211 (30%), Positives = 101/211 (47%), Gaps = 12/211 (5%)
Query: 113 APLAIATARGYTDCARHLIRQGAELDARVGGRAA-LHEACARAQFDCVRLLLTFGAKANV 171
+P+ A G+ R+LI QG ++ + LHEAC CV++LL GA+ N
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 172 LTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLE 231
+T + TPL + S C LLL+ GA+V +P+H AA RG + V +
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQ--PESDLASPIHEAARRGHVECVNSLIA 155
Query: 232 HGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNA 291
+G ++ + S T L AC + +A ++LLE+GAD G+ + +PLH
Sbjct: 156 YGGNIDHKISHLGTPLYLACE--------NQQRACVKKLLESGADVN-QGKGQDSPLHAV 206
Query: 292 CANGCGGLAELLLRYGARAEVPNGAGHTPMD 322
LA LL+ +GA + N G P++
Sbjct: 207 ARTASEELACLLMDFGADTQAKNAEGKRPVE 237
Score = 73.2 bits (178), Expect = 5e-13
Identities = 87/299 (29%), Positives = 121/299 (40%), Gaps = 46/299 (15%)
Query: 147 LHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAA 206
+HEA +R L++ G N++T + +PLH + L C K+LL+ GA VN
Sbjct: 40 MHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVT 99
Query: 207 GESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAA 266
+ TPL A G V L L+HGA V Q E+ L + A G H
Sbjct: 100 AD-WHTPLFNACVSGSWDCVNLLLQHGASV-----QPESDLASPIHEAARRG----HVEC 149
Query: 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
L+ G + TPL+ AC N + LL GA +V G G D L
Sbjct: 150 VNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGA--DVNQGKGQ---DSPLH 204
Query: 327 AVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCANFPRALEVLLNAYPCVPSCETWVEAV 386
AV + + E L L+D+GA A R +E+ VP E+
Sbjct: 205 AVARTAS---EELACLLMDFGADTQAKN-----AEGKRPVEL-------VPP-----ESP 244
Query: 387 LPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLL 445
L +L+ E E P L L RL +R G + T+L LP L+ +LL
Sbjct: 245 LAQLFLEREG-----------PPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLL 292
Score = 64.7 bits (156), Expect = 2e-10
Identities = 47/178 (26%), Positives = 75/178 (42%), Gaps = 35/178 (19%)
Query: 100 QGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAEL------------DARVGG---- 143
QG+ V +PL A G+ C + L++ GA++ +A V G
Sbjct: 58 QGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDC 117
Query: 144 -----------------RAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIP 186
+ +HEA R +CV L+ +G + TPL+L
Sbjct: 118 VNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACEN 177
Query: 187 ESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGE 244
+ C K LLE+GA VN G+ Q++PLH A E+ L ++ GAD + ++G+
Sbjct: 178 QQRACVKKLLESGADVN--QGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGK 233
Score = 50.4 bits (119), Expect = 3e-06
Identities = 31/103 (30%), Positives = 47/103 (45%), Gaps = 8/103 (7%)
Query: 209 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAAR 268
S +P+H AA G + + + G V + T+ + L+ AC G H + +
Sbjct: 35 SDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGG--------HLSCVK 86
Query: 269 RLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAE 311
LL+ GA HTPL NAC +G LLL++GA +
Sbjct: 87 ILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQ 129
Score = 43.5 bits (101), Expect = 4e-04
Identities = 31/112 (27%), Positives = 47/112 (41%), Gaps = 6/112 (5%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLT 173
PL +A C + L+ GA+++ G + LH A + LL+ FGA
Sbjct: 170 PLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKN 229
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQH 225
EG P+ L +P A+L LE +L Q L + G++QH
Sbjct: 230 AEGKRPVEL--VPPESPLAQLFLEREGPPSL----MQLCRLRIRKCFGIQQH 275
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 94.4 bits (233), Expect = 2e-19
Identities = 75/279 (26%), Positives = 108/279 (38%), Gaps = 23/279 (8%)
Query: 60 AVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFW------------VLTP 107
A+H A +G+++ V L N + L W+A G V
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFG 166
K PL A + G + +HL+ G E+D V G ALH AC Q V L+ +G
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYG 237
Query: 167 AKANVLTEEGTTPLHLCTIP-ESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQH 225
A N G TPLH C +LL+ GA VN+ + + + +PLH+ A G
Sbjct: 238 ANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGK-SPLHMTAVHGRFTR 296
Query: 226 VALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRH 285
+++G ++ G T L+ A H+ L +GAD G
Sbjct: 297 SQTLIQNGGEIDCVDKDGNTPLHVAARYG--------HELLINTLRTSGADTAKCGIHSM 348
Query: 286 TPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
PLH A N LL G + P+ G T + A
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAA 387
Score = 86.3 bits (212), Expect = 5e-17
Identities = 71/265 (26%), Positives = 107/265 (40%), Gaps = 31/265 (11%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA 120
+H A F G+ + ++ L N A+ W+ PL A A
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVN-------------AKDNMWL--------TPLHRAVA 58
Query: 121 RGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTP 179
+ + LI+ A+++AR + LH A A C +++ + NV G T
Sbjct: 59 SRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Query: 180 LHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLR 239
LH + ++ LLL GA +N A + LH AA G VAL + HGA+V +
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANIN-AFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 240 TSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGL 299
+G T L+ A + + + LL G + +T LH AC NG +
Sbjct: 178 DKKGYTPLHAAASNGQ--------INVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAV 229
Query: 300 AELLLRYGARAEVPNGAGHTPMDCA 324
L+ YGA PN G TP+ A
Sbjct: 230 VNELIDYGANVNQPNNNGFTPLHFA 254
Score = 83.6 bits (205), Expect = 3e-16
Identities = 68/251 (27%), Positives = 114/251 (45%), Gaps = 17/251 (6%)
Query: 104 VLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLL 162
V T +++ PL +A G + LI GA ++A+ LH A A + V++L
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68
Query: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
+ A N + TPLH+ ++++CA++++ ++VN++ T LH AA G
Sbjct: 69 IKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVS-DRGGRTALHHAALNGH 127
Query: 223 EQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGR 282
+ V L L GA++ + AL+ A + H L+ GA+ +
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWA--------AYMGHLDVVALLINHGAEVTCKDK 179
Query: 283 KRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAA 342
K +TPLH A +NG + + LL G + N G+T + A QD+ +
Sbjct: 180 KGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDA-------VVNE 232
Query: 343 LLDYGAQPVRP 353
L+DYGA +P
Sbjct: 233 LIDYGANVNQP 243
Score = 71.6 bits (174), Expect = 1e-12
Identities = 63/243 (25%), Positives = 102/243 (41%), Gaps = 42/243 (17%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A ++DC R L+ G E+D GR LH A A +C++LL + GA +
Sbjct: 350 PLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQH------- 225
+ G TPLH C + L+ GA VN + T LH AAA ++++
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNA 468
Query: 226 ---------------------VALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQ 264
+ L++ A+ +R +G +++ A A H+
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYG--------HR 520
Query: 265 AAARRLLE---AGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPM 321
LLE +G + +G + +PLH A NG E+LL+ ++ + G T +
Sbjct: 521 QCLELLLERTNSGFEESDSGATK-SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTAL 579
Query: 322 DCA 324
D A
Sbjct: 580 DLA 582
Score = 67.4 bits (163), Expect = 3e-11
Identities = 66/224 (29%), Positives = 92/224 (41%), Gaps = 18/224 (8%)
Query: 110 KQTAPLAIATARGYTDCARHLIRQGAELDAR--VGGRAALHEACARAQFDCVRLLLTFG- 166
K L +A +G+T+C LI GA + + V R LH + C+RLLL
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633
Query: 167 --AKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQ 224
+V +G TPL L + LLLE A V+ T LH G E+
Sbjct: 634 NPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVD-TVDILGCTALHRGIMTGHEE 692
Query: 225 HVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLE---AGADARAAG 281
V + LE + + S+G T L+ A A R H LL+ + D
Sbjct: 693 CVQMLLEQEVSILCKDSRGRTPLHYAAA--------RGHATWLSELLQMALSEEDCCFKD 744
Query: 282 RKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCAL 325
+ +TPLH AC NG E+LL + G TP+ CA+
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLLEQKCFRKF-IGNPFTPLHCAI 787
Score = 63.2 bits (152), Expect = 5e-10
Identities = 68/252 (26%), Positives = 101/252 (40%), Gaps = 38/252 (15%)
Query: 60 AVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIAT 119
A+H+ + +G+ + VQ L + E + +L ++ PL A
Sbjct: 681 ALHRGIMTGHEECVQMLLEQEVS---------------------ILCKDSRGRTPLHYAA 719
Query: 120 ARGYTDCARHLIRQG-AELDARVG---GRAALHEACARAQFDCVRLLLTFGAKANVLTEE 175
ARG+ L++ +E D G LH AC +C+ +LL +
Sbjct: 720 ARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP 779
Query: 176 GTTPLHLCTIPESLQCAKLLLEA-GATVNLAAGESQETPLHVAAARGLEQHVALYLEHGA 234
TPLH I + CA LLL A +++ + TPL AA + + L L H A
Sbjct: 780 -FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838
Query: 235 DVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLL--EAGADARAAGRKRHTPLHNAC 292
V + G+TAL A QA A +L A AD + +TPLH AC
Sbjct: 839 PVNAVDNSGKTALMMAAENG---------QAGAVDILVNSAQADLTVKDKDLNTPLHLAC 889
Query: 293 ANGCGGLAELLL 304
+ G A L+L
Sbjct: 890 SKGHEKCALLIL 901
Score = 57.0 bits (136), Expect = 3e-08
Identities = 57/232 (24%), Positives = 90/232 (38%), Gaps = 16/232 (6%)
Query: 118 ATARGYTDCARHLIRQ---GAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTE 174
A A G+ C L+ + G E ++ LH A + +LL ++ E
Sbjct: 514 AAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 175 EGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLE--- 231
+G T L L +C + L+ GA++ + ++ TPLH + G + L LE
Sbjct: 574 KGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIAD 633
Query: 232 HGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNA 291
+ V ++ ++G+T L A A H A LLE A+ T LH
Sbjct: 634 NPEAVDVKDAKGQTPLMLAVAYG--------HIDAVSLLLEKEANVDTVDILGCTALHRG 685
Query: 292 CANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAAL 343
G ++LL + G TP+ A A + W E+L AL
Sbjct: 686 IMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA--AARGHATWLSELLQMAL 735
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/313 (25%), Positives = 118/313 (37%), Gaps = 49/313 (15%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQG--------------FWVLT 106
+H A ++G+ Q ++ L Q ++ E L +A +G +V
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605
Query: 107 PKTKQTAPLAIATARGYTDCARHLIRQGAELDA----RVGGRAALHEACARAQFDCVRLL 162
TK+T PL + G+T C R L+ +A G+ L A A D V LL
Sbjct: 606 NVTKRT-PLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLL 664
Query: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
L A + + G T LH + +C ++LLE ++ L TPLH AAARG
Sbjct: 665 LEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSI-LCKDSRGRTPLHYAAARGH 723
Query: 223 EQHVALYLEHGA---DVGLRTSQGETALNTACAGAEG---------------------PG 258
++ L+ D + +QG T L+ AC P
Sbjct: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPL 783
Query: 259 SC---RRHQAAARRLLEAGADARAAGR--KRHTPLHNACANGCGGLAELLLRYGARAEVP 313
C H A LL A + + R K TPL A +LLLR+ A
Sbjct: 784 HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAV 843
Query: 314 NGAGHTPMDCALQ 326
+ +G T + A +
Sbjct: 844 DNSGKTALMMAAE 856
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/142 (24%), Positives = 57/142 (40%), Gaps = 10/142 (7%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV------GGRAALHEACARAQFDCVRLLLTFGA 167
PL A + +CA L+ +D+ + GR L A +C++LLL A
Sbjct: 782 PLHCAIINDHGNCASLLL---GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSA 838
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
N + G T L + +L+ + + TPLH+A ++G E+
Sbjct: 839 PVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCAL 898
Query: 228 LYLEHGADVGLRTSQGETALNT 249
L L+ D L ++ AL T
Sbjct: 899 LILDKIQDESL-INEKNNALQT 919
Score = 29.6 bits (65), Expect = 5.9
Identities = 17/56 (30%), Positives = 25/56 (44%)
Query: 270 LLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCAL 325
L+ D ++ TPLH A G + ELL+ GAR + TP+ A+
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAV 57
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 93.2 bits (230), Expect = 4e-19
Identities = 69/227 (30%), Positives = 105/227 (46%), Gaps = 10/227 (4%)
Query: 99 EQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFD 157
++G + T + PL A G+ + L+ GA + A+ G + +H A D
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352
Query: 158 CVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVA 217
CVRLLL + A+ + +T + TPLH+ + AK+LL+ GA N A + TPLH+A
Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LNGFTPLHIA 411
Query: 218 AARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADA 277
+ + + L L+ GA + T G T L+ A S H + LL+ GA
Sbjct: 412 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVA--------SFMGHLPIVKNLLQRGASP 463
Query: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
+ K TPLH A G +A+ LL+ A+ TP+ CA
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510
Score = 89.0 bits (219), Expect = 8e-18
Identities = 69/212 (32%), Positives = 98/212 (46%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A G+ A+ L+ +GA+ ++R + G LH AC + + LLL GA + +
Sbjct: 374 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 433
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
TE G TPLH+ + L K LL+ GA+ N+ + ETPLH+AA G + L++
Sbjct: 434 TESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQN 492
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
A V + +T L+ CA G H + LLE A+ A HTPLH A
Sbjct: 493 KAKVNAKAKDDQTPLH--CAARIG------HTNMVKLLLENNANPNLATTAGHTPLHIAA 544
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G LL A G TP+ A
Sbjct: 545 REGHVETVLALLEKEASQACMTKKGFTPLHVA 576
Score = 88.6 bits (218), Expect = 1e-17
Identities = 85/279 (30%), Positives = 116/279 (41%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGF-----WVLTPKTKQTA-- 113
+H A F G+L V+ L Q + N+ V L +A G ++L K K A
Sbjct: 441 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Query: 114 -----PLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGA 167
PL A G+T+ + L+ A + A G LH A + V LL A
Sbjct: 501 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
+T++G TPLH+ ++ A+LLLE A N AAG++ TPLHVA V
Sbjct: 561 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVK 619
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L L G G T L+ A + AR LL+ G A A + TP
Sbjct: 620 LLLPRGGSPHSPAWNGYTPLHIAAK--------QNQVEVARSLLQYGGSANAESVQGVTP 671
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL A + N +G TP+ Q
Sbjct: 672 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 710
Score = 86.3 bits (212), Expect = 5e-17
Identities = 79/242 (32%), Positives = 102/242 (42%), Gaps = 27/242 (11%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL IA + + L++ GA +DA G LH A V+ LL GA NV
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ TPLH+ + AK LL+ A VN A + Q TPLH AA G V L LE+
Sbjct: 467 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLEN 525
Query: 233 GADVGLRTSQGETALNTACAGA-----------EGPGSCRR-------HQAA-------A 267
A+ L T+ G T L+ A E +C H AA A
Sbjct: 526 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 585
Query: 268 RRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQA 327
LLE A AAG+ TPLH A + + +LLL G P G+TP+ A +
Sbjct: 586 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 645
Query: 328 VQ 329
Q
Sbjct: 646 NQ 647
Score = 80.5 bits (197), Expect = 3e-15
Identities = 65/212 (30%), Positives = 91/212 (42%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLI-RQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A D + L+ R G+ G LH A + Q + R LL +G AN
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ +G TPLHL + LLL A NL +S TPLH+ A G + ++H
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-GNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
G V T G T L+ A S + + LL+ AD A + ++PLH A
Sbjct: 724 GVMVDATTRMGYTPLHVA--------SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 775
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + LLL+ GA + G TP+ A
Sbjct: 776 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 73.9 bits (180), Expect = 3e-13
Identities = 85/345 (24%), Positives = 133/345 (38%), Gaps = 53/345 (15%)
Query: 26 EDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVH--QALFSGNLQQVQALFQDEEAA 83
+D A Q+ + + + R +R + D A +A SGNL + ++
Sbjct: 12 KDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDI 71
Query: 84 NMIVETVSNQLAWSAEQGFWVL------------TPKTKQTAPLAIATARGYTDCARHLI 131
N + N L ++++G + T K L IA G + R L+
Sbjct: 72 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 131
Query: 132 RQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL---------- 180
GA ++A+ G L+ A + V+ LL GA NV TE+G TPL
Sbjct: 132 NYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHEN 191
Query: 181 -------------------HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARG 221
H+ + + A +LL+ ++ + ++ TPLH+AA
Sbjct: 192 VVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLS-KTGFTPLHIAAHYE 250
Query: 222 LEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAG 281
L L GA V G T L+ A S R + R LL+ GA
Sbjct: 251 NLNVAQLLLNRGASVNFTPQNGITPLHIA--------SRRGNVIMVRLLLDRGAQIETKT 302
Query: 282 RKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
+ TPLH A NG ++E+LL +GA + G +P+ A Q
Sbjct: 303 KDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 347
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 93.2 bits (230), Expect = 4e-19
Identities = 69/227 (30%), Positives = 105/227 (46%), Gaps = 10/227 (4%)
Query: 99 EQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFD 157
++G + T + PL A G+ + L+ GA + A+ G + +H A D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 158 CVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVA 217
CVRLLL + A+ + +T + TPLH+ + AK+LL+ GA N A + TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LNGFTPLHIA 378
Query: 218 AARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADA 277
+ + + L L+ GA + T G T L+ A S H + LL+ GA
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVA--------SFMGHLPIVKNLLQRGASP 430
Query: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
+ K TPLH A G +A+ LL+ A+ TP+ CA
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 89.0 bits (219), Expect = 8e-18
Identities = 69/212 (32%), Positives = 98/212 (46%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A G+ A+ L+ +GA+ ++R + G LH AC + + LLL GA + +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
TE G TPLH+ + L K LL+ GA+ N+ + ETPLH+AA G + L++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
A V + +T L+ CA G H + LLE A+ A HTPLH A
Sbjct: 460 KAKVNAKAKDDQTPLH--CAARIG------HTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G LL A G TP+ A
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 88.6 bits (218), Expect = 1e-17
Identities = 85/279 (30%), Positives = 116/279 (41%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGF-----WVLTPKTKQTA-- 113
+H A F G+L V+ L Q + N+ V L +A G ++L K K A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 114 -----PLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGA 167
PL A G+T+ + L+ A + A G LH A + V LL A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
+T++G TPLH+ ++ A+LLLE A N AAG++ TPLHVA V
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVK 586
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L L G G T L+ A + AR LL+ G A A + TP
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAK--------QNQVEVARSLLQYGGSANAESVQGVTP 638
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL A + N +G TP+ Q
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Score = 86.3 bits (212), Expect = 5e-17
Identities = 79/242 (32%), Positives = 102/242 (42%), Gaps = 27/242 (11%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL IA + + L++ GA +DA G LH A V+ LL GA NV
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ TPLH+ + AK LL+ A VN A + Q TPLH AA G V L LE+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLEN 492
Query: 233 GADVGLRTSQGETALNTACAGA-----------EGPGSCRR-------HQAA-------A 267
A+ L T+ G T L+ A E +C H AA A
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 268 RRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQA 327
LLE A AAG+ TPLH A + + +LLL G P G+TP+ A +
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 328 VQ 329
Q
Sbjct: 613 NQ 614
Score = 80.5 bits (197), Expect = 3e-15
Identities = 65/212 (30%), Positives = 91/212 (42%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLI-RQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A D + L+ R G+ G LH A + Q + R LL +G AN
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ +G TPLHL + LLL A NL +S TPLH+ A G + ++H
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-GNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
G V T G T L+ A S + + LL+ AD A + ++PLH A
Sbjct: 691 GVMVDATTRMGYTPLHVA--------SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + LLL+ GA + G TP+ A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.9 bits (180), Expect = 3e-13
Identities = 69/232 (29%), Positives = 97/232 (41%), Gaps = 23/232 (9%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A+ G+ L+ + L+ G ALH A Q + VR L+ +GA N +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHG 233
++G TPL++ L+ K LLE GA N+A E TPL VA +G E VA + +G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVAT-EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 ADVGLR------TSQGETALNTACAGAEGP--------GSCRRHQAA-------ARRLLE 272
+R ++ + A P G H AA A+ LL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 273 AGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
GA + TPLH A G + LLL GA+ E TP+ CA
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.8 bits (177), Expect = 6e-13
Identities = 69/251 (27%), Positives = 100/251 (39%), Gaps = 39/251 (15%)
Query: 106 TPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLT 164
T K L IA G + R L+ GA ++A+ G L+ A + V+ LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 165 FGAKANVLTEEGTTPL-----------------------------HLCTIPESLQCAKLL 195
GA NV TE+G TPL H+ + + A +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 196 LEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAE 255
L+ ++ + ++ TPLH+AA L L GA V G T L+ A
Sbjct: 193 LQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA----- 246
Query: 256 GPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNG 315
S R + R LL+ GA + TPLH A NG ++E+LL +GA +
Sbjct: 247 ---SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 316 AGHTPMDCALQ 326
G +P+ A Q
Sbjct: 304 NGLSPIHMAAQ 314
Score = 55.8 bits (133), Expect = 8e-08
Identities = 56/208 (26%), Positives = 83/208 (39%), Gaps = 14/208 (6%)
Query: 118 ATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEG 176
A G D A +R G +++ G LH A V LL T++G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 177 TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADV 236
T LH+ + + + L+ GA VN A + TPL++AA + V LE+GA+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 237 GLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGC 296
+ T G T L A + H+ L+ G G+ R LH A N
Sbjct: 138 NVATEDGFTPLAVALQ--------QGHENVVAHLINYG----TKGKVRLPALHIAARNDD 185
Query: 297 GGLAELLLRYGARAEVPNGAGHTPMDCA 324
A +LL+ +V + G TP+ A
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Score = 31.2 bits (69), Expect = 2.0
Identities = 31/120 (25%), Positives = 43/120 (35%), Gaps = 9/120 (7%)
Query: 208 ESQETPLHVAAARGLEQHVAL-YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAA 266
E+ + AAR AL +L +G D+ G L+ A S H
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLA--------SKEGHVKM 60
Query: 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LL +K +T LH A G + L+ YGA + G TP+ A Q
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 93.2 bits (230), Expect = 4e-19
Identities = 69/227 (30%), Positives = 105/227 (46%), Gaps = 10/227 (4%)
Query: 99 EQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFD 157
++G + T + PL A G+ + L+ GA + A+ G + +H A D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 158 CVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVA 217
CVRLLL + A+ + +T + TPLH+ + AK+LL+ GA N A + TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LNGFTPLHIA 378
Query: 218 AARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADA 277
+ + + L L+ GA + T G T L+ A S H + LL+ GA
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVA--------SFMGHLPIVKNLLQRGASP 430
Query: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
+ K TPLH A G +A+ LL+ A+ TP+ CA
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 89.0 bits (219), Expect = 8e-18
Identities = 69/212 (32%), Positives = 98/212 (46%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A G+ A+ L+ +GA+ ++R + G LH AC + + LLL GA + +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
TE G TPLH+ + L K LL+ GA+ N+ + ETPLH+AA G + L++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
A V + +T L+ CA G H + LLE A+ A HTPLH A
Sbjct: 460 KAKVNAKAKDDQTPLH--CAARIG------HTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G LL A G TP+ A
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 88.6 bits (218), Expect = 1e-17
Identities = 85/279 (30%), Positives = 116/279 (41%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGF-----WVLTPKTKQTA-- 113
+H A F G+L V+ L Q + N+ V L +A G ++L K K A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 114 -----PLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGA 167
PL A G+T+ + L+ A + A G LH A + V LL A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
+T++G TPLH+ ++ A+LLLE A N AAG++ TPLHVA V
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVK 586
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L L G G T L+ A + AR LL+ G A A + TP
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAK--------QNQVEVARSLLQYGGSANAESVQGVTP 638
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL A + N +G TP+ Q
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Score = 86.3 bits (212), Expect = 5e-17
Identities = 79/242 (32%), Positives = 102/242 (42%), Gaps = 27/242 (11%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL IA + + L++ GA +DA G LH A V+ LL GA NV
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ TPLH+ + AK LL+ A VN A + Q TPLH AA G V L LE+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLEN 492
Query: 233 GADVGLRTSQGETALNTACAGA-----------EGPGSCRR-------HQAA-------A 267
A+ L T+ G T L+ A E +C H AA A
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 268 RRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQA 327
LLE A AAG+ TPLH A + + +LLL G P G+TP+ A +
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 328 VQ 329
Q
Sbjct: 613 NQ 614
Score = 80.5 bits (197), Expect = 3e-15
Identities = 65/212 (30%), Positives = 91/212 (42%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLI-RQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A D + L+ R G+ G LH A + Q + R LL +G AN
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ +G TPLHL + LLL A NL +S TPLH+ A G + ++H
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-GNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
G V T G T L+ A S + + LL+ AD A + ++PLH A
Sbjct: 691 GVMVDATTRMGYTPLHVA--------SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + LLL+ GA + G TP+ A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.9 bits (180), Expect = 3e-13
Identities = 69/232 (29%), Positives = 97/232 (41%), Gaps = 23/232 (9%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A+ G+ L+ + L+ G ALH A Q + VR L+ +GA N +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHG 233
++G TPL++ L+ K LLE GA N+A E TPL VA +G E VA + +G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVAT-EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 ADVGLR------TSQGETALNTACAGAEGP--------GSCRRHQAA-------ARRLLE 272
+R ++ + A P G H AA A+ LL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 273 AGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
GA + TPLH A G + LLL GA+ E TP+ CA
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.8 bits (177), Expect = 6e-13
Identities = 69/251 (27%), Positives = 100/251 (39%), Gaps = 39/251 (15%)
Query: 106 TPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLT 164
T K L IA G + R L+ GA ++A+ G L+ A + V+ LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 165 FGAKANVLTEEGTTPL-----------------------------HLCTIPESLQCAKLL 195
GA NV TE+G TPL H+ + + A +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 196 LEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAE 255
L+ ++ + ++ TPLH+AA L L GA V G T L+ A
Sbjct: 193 LQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA----- 246
Query: 256 GPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNG 315
S R + R LL+ GA + TPLH A NG ++E+LL +GA +
Sbjct: 247 ---SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 316 AGHTPMDCALQ 326
G +P+ A Q
Sbjct: 304 NGLSPIHMAAQ 314
Score = 55.8 bits (133), Expect = 8e-08
Identities = 56/208 (26%), Positives = 83/208 (39%), Gaps = 14/208 (6%)
Query: 118 ATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEG 176
A G D A +R G +++ G LH A V LL T++G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 177 TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADV 236
T LH+ + + + L+ GA VN A + TPL++AA + V LE+GA+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 237 GLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGC 296
+ T G T L A + H+ L+ G G+ R LH A N
Sbjct: 138 NVATEDGFTPLAVALQ--------QGHENVVAHLINYG----TKGKVRLPALHIAARNDD 185
Query: 297 GGLAELLLRYGARAEVPNGAGHTPMDCA 324
A +LL+ +V + G TP+ A
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Score = 31.2 bits (69), Expect = 2.0
Identities = 31/120 (25%), Positives = 43/120 (35%), Gaps = 9/120 (7%)
Query: 208 ESQETPLHVAAARGLEQHVAL-YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAA 266
E+ + AAR AL +L +G D+ G L+ A S H
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLA--------SKEGHVKM 60
Query: 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LL +K +T LH A G + L+ YGA + G TP+ A Q
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 93.2 bits (230), Expect = 4e-19
Identities = 69/227 (30%), Positives = 105/227 (46%), Gaps = 10/227 (4%)
Query: 99 EQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFD 157
++G + T + PL A G+ + L+ GA + A+ G + +H A D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 158 CVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVA 217
CVRLLL + A+ + +T + TPLH+ + AK+LL+ GA N A + TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LNGFTPLHIA 378
Query: 218 AARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADA 277
+ + + L L+ GA + T G T L+ A S H + LL+ GA
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVA--------SFMGHLPIVKNLLQRGASP 430
Query: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
+ K TPLH A G +A+ LL+ A+ TP+ CA
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 89.0 bits (219), Expect = 8e-18
Identities = 69/212 (32%), Positives = 98/212 (46%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A G+ A+ L+ +GA+ ++R + G LH AC + + LLL GA + +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
TE G TPLH+ + L K LL+ GA+ N+ + ETPLH+AA G + L++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
A V + +T L+ CA G H + LLE A+ A HTPLH A
Sbjct: 460 KAKVNAKAKDDQTPLH--CAARIG------HTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G LL A G TP+ A
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 88.6 bits (218), Expect = 1e-17
Identities = 85/279 (30%), Positives = 116/279 (41%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGF-----WVLTPKTKQTA-- 113
+H A F G+L V+ L Q + N+ V L +A G ++L K K A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 114 -----PLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGA 167
PL A G+T+ + L+ A + A G LH A + V LL A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
+T++G TPLH+ ++ A+LLLE A N AAG++ TPLHVA V
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVK 586
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L L G G T L+ A + AR LL+ G A A + TP
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAK--------QNQVEVARSLLQYGGSANAESVQGVTP 638
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL A + N +G TP+ Q
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Score = 86.3 bits (212), Expect = 5e-17
Identities = 79/242 (32%), Positives = 102/242 (42%), Gaps = 27/242 (11%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL IA + + L++ GA +DA G LH A V+ LL GA NV
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ TPLH+ + AK LL+ A VN A + Q TPLH AA G V L LE+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLEN 492
Query: 233 GADVGLRTSQGETALNTACAGA-----------EGPGSCRR-------HQAA-------A 267
A+ L T+ G T L+ A E +C H AA A
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 268 RRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQA 327
LLE A AAG+ TPLH A + + +LLL G P G+TP+ A +
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 328 VQ 329
Q
Sbjct: 613 NQ 614
Score = 80.5 bits (197), Expect = 3e-15
Identities = 65/212 (30%), Positives = 91/212 (42%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLI-RQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A D + L+ R G+ G LH A + Q + R LL +G AN
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ +G TPLHL + LLL A NL +S TPLH+ A G + ++H
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-GNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
G V T G T L+ A S + + LL+ AD A + ++PLH A
Sbjct: 691 GVMVDATTRMGYTPLHVA--------SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + LLL+ GA + G TP+ A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.9 bits (180), Expect = 3e-13
Identities = 69/232 (29%), Positives = 97/232 (41%), Gaps = 23/232 (9%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A+ G+ L+ + L+ G ALH A Q + VR L+ +GA N +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHG 233
++G TPL++ L+ K LLE GA N+A E TPL VA +G E VA + +G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVAT-EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 ADVGLR------TSQGETALNTACAGAEGP--------GSCRRHQAA-------ARRLLE 272
+R ++ + A P G H AA A+ LL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 273 AGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
GA + TPLH A G + LLL GA+ E TP+ CA
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.8 bits (177), Expect = 6e-13
Identities = 69/251 (27%), Positives = 100/251 (39%), Gaps = 39/251 (15%)
Query: 106 TPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLT 164
T K L IA G + R L+ GA ++A+ G L+ A + V+ LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 165 FGAKANVLTEEGTTPL-----------------------------HLCTIPESLQCAKLL 195
GA NV TE+G TPL H+ + + A +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 196 LEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAE 255
L+ ++ + ++ TPLH+AA L L GA V G T L+ A
Sbjct: 193 LQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA----- 246
Query: 256 GPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNG 315
S R + R LL+ GA + TPLH A NG ++E+LL +GA +
Sbjct: 247 ---SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 316 AGHTPMDCALQ 326
G +P+ A Q
Sbjct: 304 NGLSPIHMAAQ 314
Score = 55.8 bits (133), Expect = 8e-08
Identities = 56/208 (26%), Positives = 83/208 (39%), Gaps = 14/208 (6%)
Query: 118 ATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEG 176
A G D A +R G +++ G LH A V LL T++G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 177 TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADV 236
T LH+ + + + L+ GA VN A + TPL++AA + V LE+GA+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 237 GLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGC 296
+ T G T L A + H+ L+ G G+ R LH A N
Sbjct: 138 NVATEDGFTPLAVALQ--------QGHENVVAHLINYG----TKGKVRLPALHIAARNDD 185
Query: 297 GGLAELLLRYGARAEVPNGAGHTPMDCA 324
A +LL+ +V + G TP+ A
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Score = 31.2 bits (69), Expect = 2.0
Identities = 31/120 (25%), Positives = 43/120 (35%), Gaps = 9/120 (7%)
Query: 208 ESQETPLHVAAARGLEQHVAL-YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAA 266
E+ + AAR AL +L +G D+ G L+ A S H
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLA--------SKEGHVKM 60
Query: 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LL +K +T LH A G + L+ YGA + G TP+ A Q
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 93.2 bits (230), Expect = 4e-19
Identities = 69/227 (30%), Positives = 105/227 (46%), Gaps = 10/227 (4%)
Query: 99 EQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFD 157
++G + T + PL A G+ + L+ GA + A+ G + +H A D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 158 CVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVA 217
CVRLLL + A+ + +T + TPLH+ + AK+LL+ GA N A + TPLH+A
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA-LNGFTPLHIA 378
Query: 218 AARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADA 277
+ + + L L+ GA + T G T L+ A S H + LL+ GA
Sbjct: 379 CKKNHVRVMELLLKTGASIDAVTESGLTPLHVA--------SFMGHLPIVKNLLQRGASP 430
Query: 278 RAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
+ K TPLH A G +A+ LL+ A+ TP+ CA
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 89.0 bits (219), Expect = 8e-18
Identities = 69/212 (32%), Positives = 98/212 (46%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A G+ A+ L+ +GA+ ++R + G LH AC + + LLL GA + +
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
TE G TPLH+ + L K LL+ GA+ N+ + ETPLH+AA G + L++
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNV-SNVKVETPLHMAARAGHTEVAKYLLQN 459
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
A V + +T L+ CA G H + LLE A+ A HTPLH A
Sbjct: 460 KAKVNAKAKDDQTPLH--CAARIG------HTNMVKLLLENNANPNLATTAGHTPLHIAA 511
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G LL A G TP+ A
Sbjct: 512 REGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 88.6 bits (218), Expect = 1e-17
Identities = 85/279 (30%), Positives = 116/279 (41%), Gaps = 22/279 (7%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGF-----WVLTPKTKQTA-- 113
+H A F G+L V+ L Q + N+ V L +A G ++L K K A
Sbjct: 408 LHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Query: 114 -----PLAIATARGYTDCARHLIRQGAELD-ARVGGRAALHEACARAQFDCVRLLLTFGA 167
PL A G+T+ + L+ A + A G LH A + V LL A
Sbjct: 468 KDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527
Query: 168 KANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVA 227
+T++G TPLH+ ++ A+LLLE A N AAG++ TPLHVA V
Sbjct: 528 SQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVK 586
Query: 228 LYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTP 287
L L G G T L+ A + AR LL+ G A A + TP
Sbjct: 587 LLLPRGGSPHSPAWNGYTPLHIAAK--------QNQVEVARSLLQYGGSANAESVQGVTP 638
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A G + LLL A + N +G TP+ Q
Sbjct: 639 LHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Score = 86.3 bits (212), Expect = 5e-17
Identities = 79/242 (32%), Positives = 102/242 (42%), Gaps = 27/242 (11%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARV-GGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL IA + + L++ GA +DA G LH A V+ LL GA NV
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ TPLH+ + AK LL+ A VN A + Q TPLH AA G V L LE+
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLEN 492
Query: 233 GADVGLRTSQGETALNTACAGA-----------EGPGSCRR-------HQAA-------A 267
A+ L T+ G T L+ A E +C H AA A
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVA 552
Query: 268 RRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQA 327
LLE A AAG+ TPLH A + + +LLL G P G+TP+ A +
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ 612
Query: 328 VQ 329
Q
Sbjct: 613 NQ 614
Score = 80.5 bits (197), Expect = 3e-15
Identities = 65/212 (30%), Positives = 91/212 (42%), Gaps = 10/212 (4%)
Query: 114 PLAIATARGYTDCARHLI-RQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A D + L+ R G+ G LH A + Q + R LL +G AN
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEH 232
+ +G TPLHL + LLL A NL +S TPLH+ A G + ++H
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNL-GNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 233 GADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNAC 292
G V T G T L+ A S + + LL+ AD A + ++PLH A
Sbjct: 691 GVMVDATTRMGYTPLHVA--------SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAA 742
Query: 293 ANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
G + LLL+ GA + G TP+ A
Sbjct: 743 QQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 73.9 bits (180), Expect = 3e-13
Identities = 69/232 (29%), Positives = 97/232 (41%), Gaps = 23/232 (9%)
Query: 115 LAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVLT 173
L +A+ G+ L+ + L+ G ALH A Q + VR L+ +GA N +
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQS 108
Query: 174 EEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHG 233
++G TPL++ L+ K LLE GA N+A E TPL VA +G E VA + +G
Sbjct: 109 QKGFTPLYMAAQENHLEVVKFLLENGANQNVAT-EDGFTPLAVALQQGHENVVAHLINYG 167
Query: 234 ADVGLR------TSQGETALNTACAGAEGP--------GSCRRHQAA-------ARRLLE 272
+R ++ + A P G H AA A+ LL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 273 AGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
GA + TPLH A G + LLL GA+ E TP+ CA
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 72.8 bits (177), Expect = 6e-13
Identities = 69/251 (27%), Positives = 100/251 (39%), Gaps = 39/251 (15%)
Query: 106 TPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLT 164
T K L IA G + R L+ GA ++A+ G L+ A + V+ LL
Sbjct: 73 TTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Query: 165 FGAKANVLTEEGTTPL-----------------------------HLCTIPESLQCAKLL 195
GA NV TE+G TPL H+ + + A +L
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVL 192
Query: 196 LEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAE 255
L+ ++ + ++ TPLH+AA L L GA V G T L+ A
Sbjct: 193 LQNDPNPDVLS-KTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA----- 246
Query: 256 GPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNG 315
S R + R LL+ GA + TPLH A NG ++E+LL +GA +
Sbjct: 247 ---SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 316 AGHTPMDCALQ 326
G +P+ A Q
Sbjct: 304 NGLSPIHMAAQ 314
Score = 55.8 bits (133), Expect = 8e-08
Identities = 56/208 (26%), Positives = 83/208 (39%), Gaps = 14/208 (6%)
Query: 118 ATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEG 176
A G D A +R G +++ G LH A V LL T++G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 177 TTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADV 236
T LH+ + + + L+ GA VN A + TPL++AA + V LE+GA+
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVN-AQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 237 GLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGC 296
+ T G T L A + H+ L+ G G+ R LH A N
Sbjct: 138 NVATEDGFTPLAVALQ--------QGHENVVAHLINYG----TKGKVRLPALHIAARNDD 185
Query: 297 GGLAELLLRYGARAEVPNGAGHTPMDCA 324
A +LL+ +V + G TP+ A
Sbjct: 186 TRTAAVLLQNDPNPDVLSKTGFTPLHIA 213
Score = 31.2 bits (69), Expect = 2.0
Identities = 31/120 (25%), Positives = 43/120 (35%), Gaps = 9/120 (7%)
Query: 208 ESQETPLHVAAARGLEQHVAL-YLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAA 266
E+ + AAR AL +L +G D+ G L+ A S H
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLA--------SKEGHVKM 60
Query: 267 ARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LL +K +T LH A G + L+ YGA + G TP+ A Q
Sbjct: 61 VVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQ 120
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 92.8 bits (229), Expect = 6e-19
Identities = 81/245 (33%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 143 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV 202
G LH A ++ R LL GA N G TPLH ++ + +LLL + T
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTA 1693
Query: 203 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR 262
A E TPL +AA +E V + ADVG R G+TAL+ A A
Sbjct: 1694 VDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAA--------VN 1745
Query: 263 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMD 322
+ AAR LL+AGAD A + TPL A G +A+LLL GA E+ + AG P D
Sbjct: 1746 NARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPAD 1805
Query: 323 CALQAVQDSPNWEPEVLFAALLDYGAQPVRPEML--KHCANFPRALEVLLNAYP----CV 376
A Q +W+ L L G R + + FPRA V ++ P +
Sbjct: 1806 VAHQ----RNHWD---LLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGAL 1858
Query: 377 PSCET 381
P C T
Sbjct: 1859 PRCRT 1863
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 92.0 bits (227), Expect = 1e-18
Identities = 75/258 (29%), Positives = 102/258 (39%), Gaps = 31/258 (12%)
Query: 68 GNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCA 127
GN+Q +Q L + ++ + SN + W+A G + D
Sbjct: 390 GNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHG---------------------HVDTL 428
Query: 128 RHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIP 186
+ L LD + G ALH A D +LL +FG+ N+ +E TPLH
Sbjct: 429 KFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488
Query: 187 ESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETA 246
AK L EAG VN+ E ETPL A+ARG V EHGAD+ G A
Sbjct: 489 GYYSVAKALCEAGCNVNIKNREG-ETPLLTASARGYHDIVECLAEHGADLNACDKDGHIA 547
Query: 247 LNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRY 306
L+ A R + LL G R +TPLH AC +G + L
Sbjct: 548 LHLAVR--------RCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599
Query: 307 GARAEVPNGAGHTPMDCA 324
++ N G TP+ A
Sbjct: 600 NCNLDISNKYGRTPLHLA 617
Score = 58.9 bits (141), Expect = 9e-09
Identities = 55/224 (24%), Positives = 83/224 (37%), Gaps = 43/224 (19%)
Query: 107 PKTKQTAPLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTF 165
P T PL IA G + LI++G+ +D + GG A++ A D ++ L
Sbjct: 375 PNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 166 GAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQH 225
+V + G LH+ A+LL G+ N+ E +ETPLH AA G
Sbjct: 435 KCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKE-EETPLHCAAWHG---- 489
Query: 226 VALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRH 285
+ + A+ L EAG + R+
Sbjct: 490 -------------------------------------YYSVAKALCEAGCNVNIKNREGE 512
Query: 286 TPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQ 329
TPL A A G + E L +GA + GH + A++ Q
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQ 556
Score = 39.7 bits (91), Expect = 0.006
Identities = 41/163 (25%), Positives = 59/163 (36%), Gaps = 45/163 (27%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDA-RVGGRAALHEACARAQFDCVRLLLTFGA----- 167
PL A+ARGY D L GA+L+A G ALH A R Q + ++ LL+ G
Sbjct: 514 PLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQ 573
Query: 168 ----------------------------KANVLTEEGTTPLHLCTIPESLQCAKLLLEAG 199
++ + G TPLHL L + L G
Sbjct: 574 DRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMG 633
Query: 200 ATV-----------NLAAGESQETPLHVAAARGLEQHVALYLE 231
A+V +LA E E + A + H L+++
Sbjct: 634 ASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQ 676
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 90.5 bits (223), Expect = 3e-18
Identities = 77/291 (26%), Positives = 126/291 (43%), Gaps = 38/291 (13%)
Query: 59 PAVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIA 118
P++ QA+F+G+ +V+AL +E N ++ PL A
Sbjct: 10 PSLVQAIFNGDPDEVRALIFKKEDVNF---------------------QDNEKRTPLHAA 48
Query: 119 TARGYTDCARHLIRQGAELDARVGG-RAALHEACARAQFDCVRLLLTFGAKANVLTEEGT 177
G + LI GA ++A+ LH A A + V++LL A N +
Sbjct: 49 AYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQ 108
Query: 178 TPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVG 237
TPLH+ ++++CA+ L+ + VN++ + T LH AA G + V L L GA++
Sbjct: 109 TPLHIAAANKAVKCAEALVPLLSNVNVS-DRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
Query: 238 LRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCG 297
+ A++ A + H + L+ GA+ +K +TPLH A ++G
Sbjct: 168 AFDKKDRRAIHWA--------AYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMI 219
Query: 298 GLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGA 348
+ + LL G PN G+TP+ A QD V+ L+D GA
Sbjct: 220 SVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQD-------VVVNELIDCGA 263
Score = 89.0 bits (219), Expect = 8e-18
Identities = 72/219 (32%), Positives = 104/219 (47%), Gaps = 11/219 (5%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDARVG-GRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL +A G++DC R L+ G ++D GR LH A A +C+ LLL GA N
Sbjct: 375 PLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKK 434
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALY-LE 231
+ G +PLH + QC L+ +GA+VN E TPLH AA + Y L
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVN-DLDERGCTPLHYAATSDTDGKCLEYLLR 493
Query: 232 HGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRL----LEAGADARAAGRKRHT- 286
+ A+ G+R QG A++ + A G C + A+ L +G D + R T
Sbjct: 494 NDANPGIRDKQGYNAVH--YSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATI 551
Query: 287 -PLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA 324
PLH A +G E+L++ +V N +G TP+D A
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLA 590
Score = 77.4 bits (189), Expect = 2e-14
Identities = 65/219 (29%), Positives = 94/219 (42%), Gaps = 15/219 (6%)
Query: 114 PLAIATARGYTDCARHLIRQGAELDAR-VGGRAALHEACARAQFDCVRLLLTFGAKANVL 172
PL ++ G+TDC L+ +GA +DA+ GR ALH +CV LL GAK +
Sbjct: 656 PLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 173 TEEGTTPLHLCTIPESLQCAKLLLEAGATVN---LAAGESQETPLHVAAARGLEQHVALY 229
G TP+HL + LL++ A+++ A T LH A G E V L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 230 LEHGADVGLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEA-GAD-ARAAGRKRHTP 287
LE + ++G CA ++ AA L++ GA A K TP
Sbjct: 776 LEQEV---FQKTEGNAFSPLHCA------VINDNEGAAEMLIDTLGASIVNATDSKGRTP 826
Query: 288 LHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCALQ 326
LH A +LLL + A+ + G TP+ A +
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAE 865
Score = 73.9 bits (180), Expect = 3e-13
Identities = 76/312 (24%), Positives = 117/312 (37%), Gaps = 56/312 (17%)
Query: 60 AVHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSA------------EQGFWVLTP 107
A+H A FSG+ + V+ L N + + W+A G V
Sbjct: 143 ALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202
Query: 108 KTKQTAPLAIATARGYTDCARHLIRQGAEL-DARVGGRAALHEACARAQ-------FDC- 158
K PL A + G ++L+ G ++ + G LH AC Q DC
Sbjct: 203 DKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCG 262
Query: 159 --------------------------VRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA 192
+ LL+ GA N+ +++G TPLH+ + +
Sbjct: 263 AIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRS 322
Query: 193 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACA 252
+ ++++GA ++ ++ TPLH+AA G E + + GAD R G L+ A
Sbjct: 323 QTIIQSGAVID-CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLH--LA 379
Query: 253 GAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEV 312
G C R+LL +G D T LH A A G LLL GA
Sbjct: 380 ALSGFSDC------CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNK 433
Query: 313 PNGAGHTPMDCA 324
+ G +P+ A
Sbjct: 434 KDKFGRSPLHYA 445
Score = 72.8 bits (177), Expect = 6e-13
Identities = 72/270 (26%), Positives = 108/270 (40%), Gaps = 53/270 (19%)
Query: 99 EQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-----GRAALHEACAR 153
+ G L ++ P+ ++ A G+ L++ A +DA G ALH AC
Sbjct: 707 QHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYN 766
Query: 154 AQFDCVRLLL---------------------------------TFGAK-ANVLTEEGTTP 179
CV LLL T GA N +G TP
Sbjct: 767 GHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTP 826
Query: 180 LHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHG-ADVGL 238
LH + ++C +LLL A VN + + +TPL +AA G V + + A++ L
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVN-SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTL 885
Query: 239 RTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADAR---AAGRKRHTPLHNACANG 295
+ + TAL+ AC+ + H+ +A +LE D A TPLH A NG
Sbjct: 886 QDNSKNTALHLACS--------KGHETSALLILEKITDRNLINATNAALQTPLHVAARNG 937
Query: 296 CGGLAELLLRYGARAEVPNGAGHTP-MDCA 324
+ + LL GA + G+TP + CA
Sbjct: 938 LTMVVQELLGKGASVLAVDENGYTPALACA 967
Score = 62.0 bits (149), Expect = 1e-09
Identities = 77/288 (26%), Positives = 116/288 (40%), Gaps = 35/288 (12%)
Query: 61 VHQALFSGNLQQVQALFQ---DEEAANMIVETVSNQLAWSAE---------QGFWVLTPK 108
+H A + G+ Q ++ L Q D + N T + A+ QG +L
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 109 --TKQTAPLAIATARGYTDCARHLIRQGAE---LDARVG-GRAALHEACARAQFDCVRLL 162
K+T P+ A G+++C R LI +D + G G+ L + DCV L
Sbjct: 614 YILKRT-PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSL 672
Query: 163 LTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGL 222
L GA + + G T LH + +C LL+ GA L + TP+H++AA G
Sbjct: 673 LNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR-TPIHLSAACGH 731
Query: 223 EQHVALYLEHGADV----GLRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADAR 278
+ L+ A + + G TAL+ AC H+ LLE +
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNG--------HETCVELLLEQEVFQK 783
Query: 279 AAGRKRHTPLHNACANGCGGLAELLL-RYGAR-AEVPNGAGHTPMDCA 324
G +PLH A N G AE+L+ GA + G TP+ A
Sbjct: 784 TEG-NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAA 830
Score = 32.7 bits (73), Expect = 0.69
Identities = 38/157 (24%), Positives = 61/157 (38%), Gaps = 25/157 (15%)
Query: 61 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA 120
+H A F+ +++ +Q L N + T L +AE G T + +++A
Sbjct: 827 LHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENG-------QTNTVEMLVSSA 879
Query: 121 RGYTDCARHLIRQGAELDARVGGR-AALHEACARAQFDCVRLLLTFGAKANVLTEEGT-- 177
AEL + + ALH AC++ L+L N++
Sbjct: 880 -------------SAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAAL 926
Query: 178 -TPLHLCTIPESLQCAKLLLEAGATVNLAAGESQETP 213
TPLH+ + LL GA+V LA E+ TP
Sbjct: 927 QTPLHVAARNGLTMVVQELLGKGASV-LAVDENGYTP 962
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.133 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,241,112
Number of Sequences: 37866
Number of extensions: 823059
Number of successful extensions: 6343
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 317
Number of HSP's successfully gapped in prelim test: 51
Number of HSP's that attempted gapping in prelim test: 2301
Number of HSP's gapped (non-prelim): 1579
length of query: 453
length of database: 18,247,518
effective HSP length: 106
effective length of query: 347
effective length of database: 14,233,722
effective search space: 4939101534
effective search space used: 4939101534
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.