Guide to the Human Genome
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Search of human proteins with 24308452

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24308452 WD repeat domain 85 [Homo sapiens]
         (452 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|24308452 WD repeat domain 85 [Homo sapiens]                        953   0.0  
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             54   3e-07
gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo s...    54   4e-07
gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo...    54   4e-07
gi|58331266 WD repeat domain 59 [Homo sapiens]                         54   4e-07
gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s...    53   5e-07
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      49   1e-05
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              47   3e-05
gi|188219762 denticleless homolog [Homo sapiens]                       47   4e-05
gi|217330644 WD repeat domain 12 protein [Homo sapiens]                47   4e-05
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     45   2e-04
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    45   2e-04
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    42   9e-04
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    42   9e-04
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    42   9e-04
gi|13376840 WD repeat domain 61 [Homo sapiens]                         42   9e-04
gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]              42   0.001
gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]              42   0.001
gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]              42   0.001
gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]          40   0.003
gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]          40   0.003
gi|168229161 coronin 7 [Homo sapiens]                                  40   0.004
gi|14149696 SEC31 homolog B [Homo sapiens]                             40   0.004
gi|13129110 WD repeat domain 77 [Homo sapiens]                         40   0.004
gi|62234438 Notchless gene homolog isoform b [Homo sapiens]            40   0.004
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            40   0.004
gi|118402582 cell division cycle 20 [Homo sapiens]                     40   0.006
gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]                     39   0.007
gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]                     39   0.007
gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]                      39   0.007

>gi|24308452 WD repeat domain 85 [Homo sapiens]
          Length = 452

 Score =  953 bits (2463), Expect = 0.0
 Identities = 452/452 (100%), Positives = 452/452 (100%)

Query: 1   MMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGMEVKEPQ 60
           MMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGMEVKEPQ
Sbjct: 1   MMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGMEVKEPQ 60

Query: 61  VRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLR 120
           VRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLR
Sbjct: 61  VRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLR 120

Query: 121 LVESEKSHVLEPLSSLALEEQCLALSLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMVNE 180
           LVESEKSHVLEPLSSLALEEQCLALSLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMVNE
Sbjct: 121 LVESEKSHVLEPLSSLALEEQCLALSLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMVNE 180

Query: 181 TRPRLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTM 240
           TRPRLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTM
Sbjct: 181 TRPRLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTM 240

Query: 241 GVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLA 300
           GVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLA
Sbjct: 241 GVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLA 300

Query: 301 ACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWSWLLFRSLQRAPSWSFPSNL 360
           ACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWSWLLFRSLQRAPSWSFPSNL
Sbjct: 301 ACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWSWLLFRSLQRAPSWSFPSNL 360

Query: 361 GTKTADLKGASELPTPCHECREDNDGEGHARPQSGMKPLTEGMRKNGTWLQATAATTRDC 420
           GTKTADLKGASELPTPCHECREDNDGEGHARPQSGMKPLTEGMRKNGTWLQATAATTRDC
Sbjct: 361 GTKTADLKGASELPTPCHECREDNDGEGHARPQSGMKPLTEGMRKNGTWLQATAATTRDC 420

Query: 421 GVNPEEADSAFSLLATCSFYDHALHLWEWEGN 452
           GVNPEEADSAFSLLATCSFYDHALHLWEWEGN
Sbjct: 421 GVNPEEADSAFSLLATCSFYDHALHLWEWEGN 452


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 3/121 (2%)

Query: 202 AFNYWHPEIVYSGGDDGLLRGWDTR--VPGKFLFTSKRHTMGVCSIQSSPHREHILATGS 259
           A++  H  +  S  DD  L  WDTR     K       HT  V  +  +P+ E ILATGS
Sbjct: 233 AWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGS 292

Query: 260 YDEHILLWDTRNMKQPL-ADTPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQKAMEE 318
            D+ + LWD RN+K  L      +  ++++ W P +  +L ++       + +  K  EE
Sbjct: 293 ADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEE 352

Query: 319 R 319
           +
Sbjct: 353 Q 353



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 2/95 (2%)

Query: 176 LMVNETRPRLQKVASW--QAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLF 233
           LM+ +TR       S    AH  E    +FN +   I+ +G  D  +  WD R     L 
Sbjct: 251 LMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLH 310

Query: 234 TSKRHTMGVCSIQSSPHREHILATGSYDEHILLWD 268
           T + H   +  +  SPH E ILA+   D  + +WD
Sbjct: 311 TFESHKDEIFQVHWSPHNETILASSGTDRRLNVWD 345


>gi|21359963 ring finger and WD repeat domain 2 isoform a [Homo
           sapiens]
          Length = 731

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 2/91 (2%)

Query: 186 QKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSI 245
           Q+   +Q H+   W   FN   P+++ SG DD  ++ W T +       S      VC +
Sbjct: 504 QRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNS--VASIEAKANVCCV 561

Query: 246 QSSPHREHILATGSYDEHILLWDTRNMKQPL 276
           + SP   + LA G  D  +  +D RN KQP+
Sbjct: 562 KFSPSSRYHLAFGCADHCVHYYDLRNTKQPI 592


>gi|50233824 ring finger and WD repeat domain 2 isoform d24 [Homo
           sapiens]
          Length = 707

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 2/91 (2%)

Query: 186 QKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSI 245
           Q+   +Q H+   W   FN   P+++ SG DD  ++ W T +       S      VC +
Sbjct: 480 QRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNS--VASIEAKANVCCV 537

Query: 246 QSSPHREHILATGSYDEHILLWDTRNMKQPL 276
           + SP   + LA G  D  +  +D RN KQP+
Sbjct: 538 KFSPSSRYHLAFGCADHCVHYYDLRNTKQPI 568


>gi|58331266 WD repeat domain 59 [Homo sapiens]
          Length = 974

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 28/82 (34%), Positives = 40/82 (48%)

Query: 217 DGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPL 276
           DG +R WD R P   +     H   +  +   P  EHILAT S D  +  WD R  ++ L
Sbjct: 169 DGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYL 228

Query: 277 ADTPVQGGVWRIKWHPFHHHLL 298
              P Q  VW+ ++ PF + L+
Sbjct: 229 NILPCQVPVWKARYTPFSNGLV 250



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 42/203 (20%), Positives = 85/203 (41%), Gaps = 20/203 (9%)

Query: 139 EEQCLALSLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMVNETRPRLQKVASWQAHQ-FE 197
           + Q  A+S+D        +G + L I++ D+  + H  +  +++  +  V  W  H  F 
Sbjct: 16  DSQATAMSVDCLGQHAVLSGRRFLYIVNLDAPFEGHRKISRQSKWDIGAV-QWNPHDSFA 74

Query: 198 AWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILAT 257
            + AA +    ++ Y   D            G+   T + HT  +  +  +     +L T
Sbjct: 75  HYFAASSNQRVDL-YKWKDGS----------GEVGTTLQGHTRVISDLDWAVFEPDLLVT 123

Query: 258 GSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQKAME 317
            S D +I +WD ++ ++P        G  ++KW+  + + L  A  H G       +  +
Sbjct: 124 SSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKNANCL--ATSHDG-----DVRIWD 176

Query: 318 ERQEATVLTSHTLPDSLVYGADW 340
           +R+ +T +       S ++G DW
Sbjct: 177 KRKPSTAVEYLAAHLSKIHGLDW 199


>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
           sapiens]
          Length = 387

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 33/164 (20%)

Query: 216 DDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQP 275
           +D  LRGWDTR   +       H   V  +  +P++++ LA+   D  +  WDTRN+ +P
Sbjct: 205 NDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEP 264

Query: 276 LADTPVQG-GVWRIKWHPFHHHLLLAACMHSGFKILNC---------------------- 312
           +         VW ++++  H  L+L     S   + N                       
Sbjct: 265 VKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQED 324

Query: 313 ----QKAMEERQEATVLTSHTLPDSLVYGADWS----WLLFRSL 348
               +K+ E  Q+  + T     DS VY  DWS    W LF SL
Sbjct: 325 HRSEEKSKEPLQDNVIATYEEHEDS-VYAVDWSSADPW-LFASL 366


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 42/137 (30%), Positives = 60/137 (43%), Gaps = 22/137 (16%)

Query: 193 AHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRV--PGKFLFTSKRHTMGVCSIQSSPH 250
           AH  +  + +++   P ++ SGGDDG L+ WD R    G  + T K+H   V S++  P 
Sbjct: 306 AHDGDVNVISWSRREPFLL-SGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQ 364

Query: 251 REHILATGSYDEHILLWDTRNMKQP----------LADTP-----VQGGVWRIK---WHP 292
              + A    D  I  WD    + P          LAD P     V  G   +K   WHP
Sbjct: 365 DSGVFAASGADHQITQWDLAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKELHWHP 424

Query: 293 FHHHLLLAACMHSGFKI 309
               LL++  + SGF I
Sbjct: 425 QCPGLLVSTAL-SGFTI 440



 Score = 28.9 bits (63), Expect = 10.0
 Identities = 20/73 (27%), Positives = 28/73 (38%), Gaps = 11/73 (15%)

Query: 224 DTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPLADTPVQG 283
           D +   K +F+   H     ++  SP     L TG   ++I LW           TP  G
Sbjct: 199 DEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLW-----------TPTDG 247

Query: 284 GVWRIKWHPFHHH 296
           G W +   PF  H
Sbjct: 248 GSWHVDQRPFVGH 260


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 41/160 (25%), Positives = 74/160 (46%), Gaps = 13/160 (8%)

Query: 146 SLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMVNETRPRLQKVASWQAHQFEAWIAAFNY 205
           S+DWS  +    G+Q +   S D T +L    V ++      + +++ H+   +   ++ 
Sbjct: 116 SVDWSQTR----GEQLVVSGSWDQTVKLWDPTVGKS------LCTFRGHESIIYSTIWSP 165

Query: 206 WHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHIL 265
             P    S   D  LR WD +  G  +     H   + S     + E++L TG+ D  + 
Sbjct: 166 HIPGCFASASGDQTLRIWDVKAAGVRIVIPA-HQAEILSCDWCKYNENLLVTGAVDCSLR 224

Query: 266 LWDTRNMKQPLADTPVQG-GVWRIKWHPFHHHLLLAACMH 304
            WD RN++QP+ +       + R+K+ PFH   +LA+C +
Sbjct: 225 GWDLRNVRQPVFELLGHTYAIRRVKFSPFHAS-VLASCSY 263



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 23/76 (30%), Positives = 38/76 (50%)

Query: 193 AHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHRE 252
           AHQ E     +  ++  ++ +G  D  LRGWD R   + +F    HT  +  ++ SP   
Sbjct: 196 AHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHA 255

Query: 253 HILATGSYDEHILLWD 268
            +LA+ SYD  +  W+
Sbjct: 256 SVLASCSYDFTVRFWN 271



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 34/100 (34%), Positives = 47/100 (47%), Gaps = 6/100 (6%)

Query: 171 GQLHLLMVNETRPRLQKVASWQAHQFEA-WIAAFNYWHPEIVYSGGDDGLLRGWDTRVPG 229
           G L +L  +E   RL +   W    F+  W  + N  H  I  SG  DG L+ WDT    
Sbjct: 46  GTLLILDPDEAGLRLFRSFDWNDGLFDVTW--SENNEHVLITCSG--DGSLQLWDTAKAA 101

Query: 230 KFLFTSKRHTMGVCSIQSSPHR-EHILATGSYDEHILLWD 268
             L   K H   V S+  S  R E ++ +GS+D+ + LWD
Sbjct: 102 GPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWD 141



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 22/83 (26%), Positives = 35/83 (42%)

Query: 186 QKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSI 245
           Q V     H +      F+ +H  ++ S   D  +R W+   P   L T + HT   C +
Sbjct: 233 QPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGL 292

Query: 246 QSSPHREHILATGSYDEHILLWD 268
             S      +A  S+DE I ++D
Sbjct: 293 DFSLQSPTQVADCSWDETIKIYD 315



 Score = 31.6 bits (70), Expect = 1.5
 Identities = 21/59 (35%), Positives = 26/59 (44%)

Query: 218 GLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPL 276
           G L   D    G  LF S     G+  +  S + EH+L T S D  + LWDT     PL
Sbjct: 46  GTLLILDPDEAGLRLFRSFDWNDGLFDVTWSENNEHVLITCSGDGSLQLWDTAKAAGPL 104


>gi|188219762 denticleless homolog [Homo sapiens]
          Length = 730

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 45/155 (29%), Positives = 67/155 (43%), Gaps = 15/155 (9%)

Query: 132 PLSSLALEEQCLALSLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMV--NETRPRLQKVA 189
           PL SL    QC       S G+TG     P     S +    H+L V   E   RL    
Sbjct: 24  PLQSLLTGYQCSGNDEHTSYGETG-VPVPPFGCTFSSAPNMEHVLAVANEEGFVRLYNTE 82

Query: 190 SWQAHQ--FEAWIAAFNY-----WHP---EIVYSGGDDGLLRGWDTRVPGKFLFTSKRHT 239
           S    +  F+ W+A +N      W P   ++V + GD    + WD +  G+ + T K H 
Sbjct: 83  SQSFRKKCFKEWMAHWNAVFDLAWVPGELKLVTAAGDQ-TAKFWDVKA-GELIGTCKGHQ 140

Query: 240 MGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQ 274
             + S+  S   + +  TG  D +I++WDTR  K+
Sbjct: 141 CSLKSVAFSKFEKAVFCTGGRDGNIMVWDTRCNKK 175


>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
          Length = 423

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 28/68 (41%), Positives = 35/68 (51%), Gaps = 2/68 (2%)

Query: 213 SGGDDGLLRGWDTRVPGKFLFTSK--RHTMGVCSIQSSPHREHILATGSYDEHILLWDTR 270
           SG  D  +R WD R     L +     HT  V S++ SP  E  L +GS D  + LWDTR
Sbjct: 314 SGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTR 373

Query: 271 NMKQPLAD 278
           + K PL D
Sbjct: 374 SCKAPLYD 381



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 51/197 (25%), Positives = 77/197 (39%), Gaps = 25/197 (12%)

Query: 159 DQPLKIISSDSTGQLHLLMVNETRPRLQK-----------VASWQAHQFEAWIAAFNYWH 207
           D+ LKI S+  T +   +  +  RPR ++           + +   H  EA +++  +  
Sbjct: 210 DKMLKIWSTVPTDEEDEMEESTNRPRKKQKTEQLGLTRTPIVTLSGHM-EA-VSSVLWSD 267

Query: 208 PEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLW 267
            E + S   D  +R WD    G    T   + +  C I  SP  +  LA+GS D HI LW
Sbjct: 268 AEEICSASWDHTIRVWDVE-SGSLKSTLTGNKVFNC-ISYSPLCKR-LASGSTDRHIRLW 324

Query: 268 DTRNMKQPLAD---TPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQKAMEERQEATV 324
           D R     L     T   G V  +KW P H   L++  +       N  K  + R     
Sbjct: 325 DPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISGSLD------NIVKLWDTRSCKAP 378

Query: 325 LTSHTLPDSLVYGADWS 341
           L      +  V   DW+
Sbjct: 379 LYDLAAHEDKVLSVDWT 395


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 23/62 (37%), Positives = 33/62 (53%), Gaps = 2/62 (3%)

Query: 209 EIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWD 268
           E++ +G   G +R WD     K L T   H   +CS+   P+ E + A+GS D +I LWD
Sbjct: 76  ELIVAGSQSGSIRVWDLEA-AKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWD 133

Query: 269 TR 270
            R
Sbjct: 134 IR 135



 Score = 33.9 bits (76), Expect = 0.31
 Identities = 26/94 (27%), Positives = 41/94 (43%), Gaps = 8/94 (8%)

Query: 213 SGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNM 272
           S  DD  ++ WD    GK +     HT  V  ++  P+ E++LA+GS D  I  WD    
Sbjct: 164 SAADDHTVKLWDLTA-GKMMSEFPGHTGPVNVVEFHPN-EYLLASGSSDRTIRFWDLEKF 221

Query: 273 KQPLADTPVQGGVWRIKWHPFHHHLLLAACMHSG 306
           +         G V  + ++P         C++SG
Sbjct: 222 QVVSCIEGEPGPVRSVLFNPD------GCCLYSG 249


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 34/124 (27%), Positives = 53/124 (42%), Gaps = 3/124 (2%)

Query: 186 QKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSI 245
           +++   + H    +  AF+     +  +GG D   R WD R  G+ +   + H   +  I
Sbjct: 356 EEILHQEGHSMGVYDIAFHQ-DGSLAGTGGLDAFGRVWDLRT-GRCIMFLEGHLKEIYGI 413

Query: 246 QSSPHREHILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLAACMHS 305
             SP+  HI ATGS D    +WD R  +        Q  V  +K+ P H + LL     +
Sbjct: 414 NFSPNGYHI-ATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDN 472

Query: 306 GFKI 309
             KI
Sbjct: 473 TAKI 476



 Score = 30.0 bits (66), Expect = 4.5
 Identities = 15/57 (26%), Positives = 26/57 (45%), Gaps = 1/57 (1%)

Query: 211 VYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLW 267
           + +G  D   + WD R   + ++T   H   V  ++  P   + L TG+YD    +W
Sbjct: 422 IATGSGDNTCKVWDLR-QRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIW 477


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 26/95 (27%), Positives = 42/95 (44%)

Query: 190 SWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSP 249
           S  AH  E    +FN +   I+ +G  D  +  WD R     L + + H   +  +Q SP
Sbjct: 233 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 292

Query: 250 HREHILATGSYDEHILLWDTRNMKQPLADTPVQGG 284
           H E ILA+   D  + +WD   + +  +    + G
Sbjct: 293 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 327



 Score = 28.9 bits (63), Expect = 10.0
 Identities = 20/94 (21%), Positives = 39/94 (41%), Gaps = 13/94 (13%)

Query: 187 KVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRV-------------PGKFLF 233
           K+ S+++H+ E +   ++  +  I+ S G D  L  WD                P + LF
Sbjct: 274 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 333

Query: 234 TSKRHTMGVCSIQSSPHREHILATGSYDEHILLW 267
               HT  +     +P+   ++ + S D  + +W
Sbjct: 334 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 367


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 26/95 (27%), Positives = 42/95 (44%)

Query: 190 SWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSP 249
           S  AH  E    +FN +   I+ +G  D  +  WD R     L + + H   +  +Q SP
Sbjct: 267 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 326

Query: 250 HREHILATGSYDEHILLWDTRNMKQPLADTPVQGG 284
           H E ILA+   D  + +WD   + +  +    + G
Sbjct: 327 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 361



 Score = 28.9 bits (63), Expect = 10.0
 Identities = 20/94 (21%), Positives = 39/94 (41%), Gaps = 13/94 (13%)

Query: 187 KVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRV-------------PGKFLF 233
           K+ S+++H+ E +   ++  +  I+ S G D  L  WD                P + LF
Sbjct: 308 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 367

Query: 234 TSKRHTMGVCSIQSSPHREHILATGSYDEHILLW 267
               HT  +     +P+   ++ + S D  + +W
Sbjct: 368 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 401


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 26/95 (27%), Positives = 42/95 (44%)

Query: 190 SWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSP 249
           S  AH  E    +FN +   I+ +G  D  +  WD R     L + + H   +  +Q SP
Sbjct: 268 SVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSP 327

Query: 250 HREHILATGSYDEHILLWDTRNMKQPLADTPVQGG 284
           H E ILA+   D  + +WD   + +  +    + G
Sbjct: 328 HNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDG 362



 Score = 28.9 bits (63), Expect = 10.0
 Identities = 20/94 (21%), Positives = 39/94 (41%), Gaps = 13/94 (13%)

Query: 187 KVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRV-------------PGKFLF 233
           K+ S+++H+ E +   ++  +  I+ S G D  L  WD                P + LF
Sbjct: 309 KLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLF 368

Query: 234 TSKRHTMGVCSIQSSPHREHILATGSYDEHILLW 267
               HT  +     +P+   ++ + S D  + +W
Sbjct: 369 IHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVW 402


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 34/110 (30%), Positives = 49/110 (44%), Gaps = 5/110 (4%)

Query: 192 QAHQFEAWIAAFNY---WHPEIVYSGGDDGLLRGWDTRVPGKFL-FTSKRHTMGVCSIQS 247
           QAH    W  A+      + E V +G  D L++ W  R     L ++ + H +GV S+  
Sbjct: 13  QAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDI 72

Query: 248 SPHREHILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHL 297
           S H   I A+ S D HI LWD  N KQ  +        W + + P   +L
Sbjct: 73  S-HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYL 121



 Score = 32.7 bits (73), Expect = 0.69
 Identities = 20/59 (33%), Positives = 33/59 (55%), Gaps = 2/59 (3%)

Query: 213 SGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRN 271
           SG  DG++  +D    GK L T + H M + S+  SP  + +L T S D +I ++D ++
Sbjct: 165 SGAIDGIINIFDIAT-GKLLHTLEGHAMPIRSLTFSPDSQ-LLVTASDDGYIKIYDVQH 221


>gi|216548382 WD repeat domain 47 isoform 3 [Homo sapiens]
          Length = 919

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 4/102 (3%)

Query: 200 IAAFNYWHPEIVYSGGDDGLLRGWDTRVPG--KFLFTSKRHT-MGVCSIQSSPHREHILA 256
           I A   W   ++ SG  D  +R WD RVP   + + T+   T   V S+   P    +LA
Sbjct: 758 ILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGR-LLA 816

Query: 257 TGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
           TG  D   +L+D R  +   +  P    V  +++ P  H+LL
Sbjct: 817 TGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLL 858


>gi|216548378 WD repeat domain 47 isoform 1 [Homo sapiens]
          Length = 927

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 4/102 (3%)

Query: 200 IAAFNYWHPEIVYSGGDDGLLRGWDTRVPG--KFLFTSKRHT-MGVCSIQSSPHREHILA 256
           I A   W   ++ SG  D  +R WD RVP   + + T+   T   V S+   P    +LA
Sbjct: 766 ILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGR-LLA 824

Query: 257 TGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
           TG  D   +L+D R  +   +  P    V  +++ P  H+LL
Sbjct: 825 TGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLL 866


>gi|216548347 WD repeat domain 47 isoform 2 [Homo sapiens]
          Length = 920

 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/102 (30%), Positives = 47/102 (46%), Gaps = 4/102 (3%)

Query: 200 IAAFNYWHPEIVYSGGDDGLLRGWDTRVPG--KFLFTSKRHT-MGVCSIQSSPHREHILA 256
           I A   W   ++ SG  D  +R WD RVP   + + T+   T   V S+   P    +LA
Sbjct: 759 ILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFHGTGSAVASVAVDPSGR-LLA 817

Query: 257 TGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
           TG  D   +L+D R  +   +  P    V  +++ P  H+LL
Sbjct: 818 TGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAHYLL 859


>gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 31/111 (27%), Positives = 49/111 (44%), Gaps = 13/111 (11%)

Query: 238 HTMGVCSIQSSPHREHILATGSYDEHILLWD--TRNMKQPLADTPV--QGGVWR---IKW 290
           HT  V  I   PH + ++A+GS D  +++W      +  PL +  V  +G   R   I W
Sbjct: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAW 140

Query: 291 HPFHHHLLLAACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWS 341
           HP   ++LL+A   +   I N   A E      +    +L   L+Y   W+
Sbjct: 141 HPTARNVLLSAGCDNVVLIWNVGTAEE------LYRLDSLHPDLIYNVSWN 185


>gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 31/111 (27%), Positives = 49/111 (44%), Gaps = 13/111 (11%)

Query: 238 HTMGVCSIQSSPHREHILATGSYDEHILLWD--TRNMKQPLADTPV--QGGVWR---IKW 290
           HT  V  I   PH + ++A+GS D  +++W      +  PL +  V  +G   R   I W
Sbjct: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAW 140

Query: 291 HPFHHHLLLAACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWS 341
           HP   ++LL+A   +   I N   A E      +    +L   L+Y   W+
Sbjct: 141 HPTARNVLLSAGCDNVVLIWNVGTAEE------LYRLDSLHPDLIYNVSWN 185


>gi|168229161 coronin 7 [Homo sapiens]
          Length = 925

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 32/128 (25%), Positives = 55/128 (42%), Gaps = 11/128 (8%)

Query: 202 AFNYWHPEIVYSGGDDGLLRGWDTRVPGKFL---FTSKR-----HTMGVCSIQSSPHREH 253
           A++ + P  +   G+D  +R W  RVP + L    T+       HT  +CS++  P   +
Sbjct: 551 AWDPFDPHRLAVAGEDARIRLW--RVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAAN 608

Query: 254 ILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQ 313
           +LA+ SYD  + +WD +     L     Q  ++ + W P     L   C     ++   +
Sbjct: 609 VLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSP-DGQQLATVCKDGRVRVYRPR 667

Query: 314 KAMEERQE 321
              E  QE
Sbjct: 668 SGPEPLQE 675



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 33/110 (30%), Positives = 49/110 (44%), Gaps = 14/110 (12%)

Query: 238 HTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPLADTP--VQG----GVWRIKWH 291
           H+  V  +  SP  + +LATGS D  + LW      Q L   P  V G     V  +++H
Sbjct: 76  HSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFH 135

Query: 292 PFHHHLLLAACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWS 341
           P    +L++A   +  K+ +  K    +Q  T L +H     LV  A WS
Sbjct: 136 PTSDGILVSAA-GTTVKVWDAAK----QQPLTELAAH---GDLVQSAVWS 177


>gi|14149696 SEC31 homolog B [Homo sapiens]
          Length = 1179

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 25/102 (24%), Positives = 52/102 (50%), Gaps = 11/102 (10%)

Query: 210 IVYSGGDDGLLRGWDTR---VPGK--FLFTSKRHTMGVCSIQSSPHREHILATGSYDEHI 264
           ++  GGD+G+L  ++       GK   +   ++HT  V ++  +P + ++LA+G+ D  I
Sbjct: 87  VIVGGGDNGMLILYNVTHILSSGKEPVIAQKQKHTGAVRALDLNPFQGNLLASGASDSEI 146

Query: 265 LLWDTRNMKQPL-----ADTPVQGGVWRIKWHPFHHHLLLAA 301
            +WD  N+  P+     +  P +  +  + W+    H+L +A
Sbjct: 147 FIWDLNNLNVPMTLGSKSQQPPE-DIKALSWNRQAQHILSSA 187


>gi|13129110 WD repeat domain 77 [Homo sapiens]
          Length = 342

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 40/170 (23%), Positives = 69/170 (40%), Gaps = 13/170 (7%)

Query: 103 GHALLGLADASGSIQL--LRLVESEKSHVLEPLSSLALEEQCLALSLDWSTGKTGRAGDQ 160
           G  LLG +  SG      L L +   +   E   S  ++ +     L W        G++
Sbjct: 40  GALLLGASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTW-------VGER 92

Query: 161 PLKIISSDSTGQLHLLMVNETRPRLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLL 220
            + + S     +L  L  NET   + K   ++     + ++  +     +  SG  D  +
Sbjct: 93  GILVASDSGAVELWELDENETLI-VSKFCKYEHDDIVSTVSVLSSGTQAV--SGSKDICI 149

Query: 221 RGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTR 270
           + WD       L + + H   V  + +SPH++ +  + S D  ILLWDTR
Sbjct: 150 KVWDL-AQQVVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTR 198


>gi|62234438 Notchless gene homolog isoform b [Homo sapiens]
          Length = 193

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 38/134 (28%), Positives = 56/134 (41%), Gaps = 9/134 (6%)

Query: 208 PEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLW 267
           PE + SG DD  L  W      K L     H   +  +  SP    I+A+ S+D+ I LW
Sbjct: 49  PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLW 107

Query: 268 DTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQKAMEERQEATVLTS 327
           D R  K   +       V++I W      LL++    S  K+ +    ++ ++ A  L  
Sbjct: 108 DGRTGKYLASLRGHVAAVYQIAWSA-DSRLLVSGSSDSTLKVWD----VKAQKLAMDLPG 162

Query: 328 HTLPDSLVYGADWS 341
           H      VY  DWS
Sbjct: 163 HA---DEVYAVDWS 173


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 38/134 (28%), Positives = 56/134 (41%), Gaps = 9/134 (6%)

Query: 208 PEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLW 267
           PE + SG DD  L  W      K L     H   +  +  SP    I+A+ S+D+ I LW
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPD-SRIVASASFDKSIKLW 399

Query: 268 DTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQKAMEERQEATVLTS 327
           D R  K   +       V++I W      LL++    S  K+ +    ++ ++ A  L  
Sbjct: 400 DGRTGKYLASLRGHVAAVYQIAWSA-DSRLLVSGSSDSTLKVWD----VKAQKLAMDLPG 454

Query: 328 HTLPDSLVYGADWS 341
           H      VY  DWS
Sbjct: 455 HA---DEVYAVDWS 465



 Score = 39.3 bits (90), Expect = 0.007
 Identities = 55/186 (29%), Positives = 70/186 (37%), Gaps = 35/186 (18%)

Query: 213 SGGDDGLLRGWD--TRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTR 270
           SG  D  +R WD  T  P    FT K H   V SI  SP     LA+G  +  ILLWD  
Sbjct: 131 SGSGDTTVRFWDLSTETPH---FTCKGHRHWVLSISWSPDGRK-LASGCKNGQILLWDPS 186

Query: 271 NMKQPLADTPVQGGVW--RIKWHPFHHH----LLLAACMHSGFKILNCQKAMEERQEATV 324
             KQ +  T      W   + W P H +     + ++      +I +      ER    +
Sbjct: 187 TGKQ-VGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCER----I 241

Query: 325 LTSHTLP--------DSLVYGAD-------W---SWLLFRSLQRAPSWSFPSNLGTKTAD 366
           LT HT          D L+Y A        W     +L R+LQ    W     L T  A 
Sbjct: 242 LTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMALSTDYAL 301

Query: 367 LKGASE 372
             GA E
Sbjct: 302 RTGAFE 307


>gi|118402582 cell division cycle 20 [Homo sapiens]
          Length = 499

 Score = 39.7 bits (91), Expect = 0.006
 Identities = 28/97 (28%), Positives = 45/97 (46%), Gaps = 5/97 (5%)

Query: 206 WHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHIL 265
           W+  I+ SG   G +   D RV    + T   H+  VC ++ +P   H LA+G  D  + 
Sbjct: 276 WNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRH-LASGGNDNLVN 334

Query: 266 LWDTRNMK---QPLAD-TPVQGGVWRIKWHPFHHHLL 298
           +W +   +    PL   T  QG V  + W P+  ++L
Sbjct: 335 VWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVL 371


>gi|209969680 Fzr1 protein isoform 1 [Homo sapiens]
          Length = 496

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 206 WHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKR---HTMGVCSIQSSPHREHILATGSYDE 262
           W+ E + SG  D ++   D R P   L + +R   H   VC ++ S   + +LA+G  D 
Sbjct: 279 WNAEQLSSGSRDRMILQRDIRTPP--LQSERRLQGHRQEVCGLKWSTDHQ-LLASGGNDN 335

Query: 263 HILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
            +L+W+  ++      T     V  I W P  H LL
Sbjct: 336 KLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 39/151 (25%), Positives = 64/151 (42%), Gaps = 8/151 (5%)

Query: 152 GKTGRAGDQPLKIISSDSTGQLHLLMVNETR-PRLQKVASWQAHQFEAWIAAFNYWHPEI 210
           G T R G          S  +  +++  + R P LQ     Q H+ E     ++  H ++
Sbjct: 269 GHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH-QL 327

Query: 211 VYSGGDDGLLRGWD-TRVPGKFLFTSKRHTMGVCSIQSSPHREHILAT--GSYDEHILLW 267
           + SGG+D  L  W+ + +     +T   H   V +I  SPH+  +LA+  G+ D  I  W
Sbjct: 328 LASGGNDNKLLVWNHSSLSPVQQYTE--HLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385

Query: 268 DTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
           +T    QPL        V  + W    + L+
Sbjct: 386 NTLT-GQPLQCIDTGSQVCNLAWSKHANELV 415


>gi|209969678 Fzr1 protein isoform 3 [Homo sapiens]
          Length = 404

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 206 WHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKR---HTMGVCSIQSSPHREHILATGSYDE 262
           W+ E + SG  D ++   D R P   L + +R   H   VC ++ S   + +LA+G  D 
Sbjct: 190 WNAEQLSSGSRDRMILQRDIRTPP--LQSERRLQGHRQEVCGLKWSTDHQ-LLASGGNDN 246

Query: 263 HILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
            +L+W+  ++      T     V  I W P  H LL
Sbjct: 247 KLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 282



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 39/151 (25%), Positives = 64/151 (42%), Gaps = 8/151 (5%)

Query: 152 GKTGRAGDQPLKIISSDSTGQLHLLMVNETR-PRLQKVASWQAHQFEAWIAAFNYWHPEI 210
           G T R G          S  +  +++  + R P LQ     Q H+ E     ++  H ++
Sbjct: 180 GHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH-QL 238

Query: 211 VYSGGDDGLLRGWD-TRVPGKFLFTSKRHTMGVCSIQSSPHREHILAT--GSYDEHILLW 267
           + SGG+D  L  W+ + +     +T   H   V +I  SPH+  +LA+  G+ D  I  W
Sbjct: 239 LASGGNDNKLLVWNHSSLSPVQQYTE--HLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 296

Query: 268 DTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
           +T    QPL        V  + W    + L+
Sbjct: 297 NTLT-GQPLQCIDTGSQVCNLAWSKHANELV 326


>gi|33620742 Fzr1 protein isoform 2 [Homo sapiens]
          Length = 493

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)

Query: 206 WHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKR---HTMGVCSIQSSPHREHILATGSYDE 262
           W+ E + SG  D ++   D R P   L + +R   H   VC ++ S   + +LA+G  D 
Sbjct: 279 WNAEQLSSGSRDRMILQRDIRTPP--LQSERRLQGHRQEVCGLKWSTDHQ-LLASGGNDN 335

Query: 263 HILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
            +L+W+  ++      T     V  I W P  H LL
Sbjct: 336 KLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLL 371



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 39/151 (25%), Positives = 64/151 (42%), Gaps = 8/151 (5%)

Query: 152 GKTGRAGDQPLKIISSDSTGQLHLLMVNETR-PRLQKVASWQAHQFEAWIAAFNYWHPEI 210
           G T R G          S  +  +++  + R P LQ     Q H+ E     ++  H ++
Sbjct: 269 GHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDH-QL 327

Query: 211 VYSGGDDGLLRGWD-TRVPGKFLFTSKRHTMGVCSIQSSPHREHILAT--GSYDEHILLW 267
           + SGG+D  L  W+ + +     +T   H   V +I  SPH+  +LA+  G+ D  I  W
Sbjct: 328 LASGGNDNKLLVWNHSSLSPVQQYTE--HLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385

Query: 268 DTRNMKQPLADTPVQGGVWRIKWHPFHHHLL 298
           +T    QPL        V  + W    + L+
Sbjct: 386 NTLT-GQPLQCIDTGSQVCNLAWSKHANELV 415


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.134    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,240,030
Number of Sequences: 37866
Number of extensions: 889811
Number of successful extensions: 2842
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 2558
Number of HSP's gapped (non-prelim): 357
length of query: 452
length of database: 18,247,518
effective HSP length: 106
effective length of query: 346
effective length of database: 14,233,722
effective search space: 4924867812
effective search space used: 4924867812
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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