Search of human proteins with 242117953

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|242117953 SH3 domain-containing protein C1orf113 isoform 1
[Homo sapiens]
         (756 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...  1534   0.0  
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H...  1305   0.0  
gi|11321634 CD2-associated protein [Homo sapiens]                     157   3e-38
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ...   111   3e-24
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]    110   4e-24
gi|110349719 titin isoform N2-A [Homo sapiens]                        100   5e-21
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]        100   9e-21
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]        100   9e-21
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]        100   9e-21
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]                97   6e-20
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                97   6e-20
gi|39930351 dynamin binding protein [Homo sapiens]                     97   6e-20
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s...    92   1e-18
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s...    92   1e-18
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa...    92   1e-18
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s...    92   1e-18
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ...    88   3e-17
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ...    88   3e-17
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...    88   3e-17
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ...    88   3e-17
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ...    88   3e-17
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ...    88   3e-17
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s...    88   3e-17
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ...    88   3e-17
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s...    87   7e-17
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   84   6e-16
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   84   6e-16
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   84   6e-16
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    84   6e-16
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]       84   6e-16

>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 1534 bits (3971), Expect = 0.0
 Identities = 756/756 (100%), Positives = 756/756 (100%)

Query: 1   MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60
           MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL
Sbjct: 1   MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60

Query: 61  RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
           RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW
Sbjct: 61  RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120

Query: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV
Sbjct: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180

Query: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240
           SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP
Sbjct: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240

Query: 241 PPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKL 300
           PPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKL
Sbjct: 241 PPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKL 300

Query: 301 TSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTA 360
           TSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTA
Sbjct: 301 TSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTA 360

Query: 361 TPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMV 420
           TPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMV
Sbjct: 361 TPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMV 420

Query: 421 TPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAP 480
           TPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAP
Sbjct: 421 TPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAP 480

Query: 481 TLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQP 540
           TLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQP
Sbjct: 481 TLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQP 540

Query: 541 PSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTP 600
           PSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTP
Sbjct: 541 PSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTP 600

Query: 601 EEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPI 660
           EEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPI
Sbjct: 601 EEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPI 660

Query: 661 KPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWE 720
           KPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWE
Sbjct: 661 KPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWE 720

Query: 721 ELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY 756
           ELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY
Sbjct: 721 ELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY 756


>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
           sapiens]
          Length = 645

 Score = 1305 bits (3376), Expect = 0.0
 Identities = 645/645 (100%), Positives = 645/645 (100%)

Query: 112 MIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYD 171
           MIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYD
Sbjct: 1   MIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYD 60

Query: 172 SPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGV 231
           SPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGV
Sbjct: 61  SPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGV 120

Query: 232 FPDNFVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
           FPDNFVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR
Sbjct: 121 FPDNFVLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR 180

Query: 292 TPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVK 351
           TPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVK
Sbjct: 181 TPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVK 240

Query: 352 RTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPD 411
           RTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPD
Sbjct: 241 RTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPD 300

Query: 412 KVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPK 471
           KVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPK
Sbjct: 301 KVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPK 360

Query: 472 MAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAH 531
           MAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAH
Sbjct: 361 MAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAH 420

Query: 532 TPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEE 591
           TPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEE
Sbjct: 421 TPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEE 480

Query: 592 APSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIER 651
           APSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIER
Sbjct: 481 APSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIER 540

Query: 652 AFAQKTRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQL 711
           AFAQKTRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQL
Sbjct: 541 AFAQKTRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQL 600

Query: 712 ERKLTDIWEELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY 756
           ERKLTDIWEELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY
Sbjct: 601 ERKLTDIWEELKSEKEQRRRLEVQVMQGTQKSQTPRVIHTQTQTY 645



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 135/564 (23%), Positives = 198/564 (35%), Gaps = 105/564 (18%)

Query: 5   VLAGYRAQKEDELSLAPGDVVRQV-RWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGS 63
           VL  Y+ +  DEL+L  GDVV+ + +    +GW  GE  GR G+FP+  V   P   +  
Sbjct: 77  VLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKK-- 134

Query: 64  GEARRPRCARRRGHPAKHPR--------PQRWCKVNFSYSPEQADELKLQAGEIVEMIK- 114
                 +   R   P K P+        P        +  P +A   +  + +  ++   
Sbjct: 135 --LVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSR 192

Query: 115 --------EIEDGWWLGKKNGQLGAFPSNFV---ELLDSGP---PSLGNPDMPSVSPGPQ 160
                   +    +  G+K  +        V   E   S P   PS+    MP  +  P+
Sbjct: 193 DSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPE 252

Query: 161 RPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ--PEAPDELALRRGDVVKVLSK--TTE 216
           RPP   +            V  PE    L D    P       +   D V    K  T E
Sbjct: 253 RPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPE 312

Query: 217 DKGWWEGECQGRRGVFPDNFVLPPPPI---KKLVPRKVVSRESAPIKEPKKLMPKTSLPT 273
           DK              P+N ++P   +   K   P +V S E +P  E     P   +P 
Sbjct: 313 DK-----------ASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAP---PMDKVPN 358

Query: 274 VKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRS 333
            K        P+  K   TP    +++++RD      F S  +    +     + P    
Sbjct: 359 PKMAPLGDEAPTLEKV-LTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDP---- 413

Query: 334 VSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLG 393
            SSQEE H                   TPE P  P   PSS++     K      TL  G
Sbjct: 414 -SSQEEAH-------------------TPEAP--PPQPPSSERCLGEMKC-----TLVRG 446

Query: 394 DKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSV 453
           D +       SG    P   P  EK    E+  ++PE           + PS  ER    
Sbjct: 447 DSSPRQAELKSG----PASRPALEKPHPHEEATTLPE-----------EAPSNDERT-PE 490

Query: 454 EESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQ 513
           EE+P  E  P+ +   PK      E  TL++ L P   +EEV+ ++++       E A  
Sbjct: 491 EEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPP---KEEVAPKEEVP----PIERAFA 543

Query: 514 KVKYFVAKEDPSSQEEAHTPEAPP 537
           + K    K  P SQE    P   P
Sbjct: 544 Q-KTRPIKPPPDSQETLALPSLVP 566


>gi|11321634 CD2-associated protein [Homo sapiens]
          Length = 639

 Score =  157 bits (398), Expect = 3e-38
 Identities = 146/562 (25%), Positives = 233/562 (41%), Gaps = 134/562 (23%)

Query: 1   MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60
           ++ +V   Y A  +DEL++  G+++R V+ +   GWL GE  GR G+FP+  V+EI    
Sbjct: 2   VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRET 61

Query: 61  RGSGEARRPRCARRRGHPAK---------------HPRPQ----------RWCKVNFSYS 95
               ++  P    R G+ A                 P PQ          R CKV F Y 
Sbjct: 62  EFKDDSL-PIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYI 120

Query: 96  PEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLD-------------- 141
           P+  DEL+L+ G+I+++ +E+E+GWW G  N +LG FPSNFV+ L+              
Sbjct: 121 PQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDS 180

Query: 142 ----SGP----PSLGNPDMPSVSPGPQRPPKLSSLAYDS--------------------- 172
               +GP    PSLGN    + S    +P K+  + +                       
Sbjct: 181 ETVLAGPTSPIPSLGNVS-ETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEK 239

Query: 173 ---PPDYLQT------------------VSHPEVYRVLFDYQPEAPDELALRRGDVVKVL 211
               P  LQ+                  +   E  R LF Y+    DEL  + G+++ ++
Sbjct: 240 KPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLI 299

Query: 212 SKTTEDKGWWEGECQGRRGVFPDNFVL--------------PPPPIKKLVPR-KVVSRES 256
           SK T + GWW GE  G+ GVFPDNF +              PPPP K   P+ ++++ E 
Sbjct: 300 SKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAKAPAPKPELIAAEK 359

Query: 257 APIK-EPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGG 315
                +P++   K++L        A   P K  T   P++ S  L           +S G
Sbjct: 360 KYFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPT--PPTKASNLL-----------RSSG 406

Query: 316 SYHPGRKRSKTQTPQQ-RSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPE----N 370
           + +P R       P     ++ +    SS  +   V +  + D    P RP + +     
Sbjct: 407 TVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKL-DSEQLPLRPKSVDFDSLT 465

Query: 371 APSSKKIPAP--DKVPSPEKTLTL-GDKASIPGNSTSGKI-PAPDKVPTPEKMV---TPE 423
             +SK+      D + S E  L L  ++  +PG    G+         +PEK++     E
Sbjct: 466 VRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEE 525

Query: 424 DKASIPENSIIPEETLTVDKPS 445
           D A++ + S + ++T    KPS
Sbjct: 526 DSANL-KPSELKKDTCYSPKPS 546


>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
           sapiens]
          Length = 665

 Score =  111 bits (277), Expect = 3e-24
 Identities = 178/791 (22%), Positives = 281/791 (35%), Gaps = 192/791 (24%)

Query: 1   MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60
           +E +V   Y+AQ +DEL+++ G+++  +R     GW  G+  GR GLFP+  V+EI + +
Sbjct: 2   VEAIVEFDYQAQHDDELTISVGEIITNIRKEDG-GWWEGQINGRRGLFPDNFVREIKKEM 60

Query: 61  RGSGEARRPRCARRRGHPA---------------KHPRPQRWCKVNFSYSPEQADELKLQ 105
           +      +         P+               +  R +R C+V FSY P+  DEL+L+
Sbjct: 61  KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120

Query: 106 AGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKL 165
            G+I+E++ E+E+GWW G  NG+ G FPSNF++ L      LG                 
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELG----------------- 163

Query: 166 SSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGEC 225
                 S  + L   S  E      D    +  +     G V     +  + KG   G+ 
Sbjct: 164 -----ISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGD- 217

Query: 226 QGRRGVFPDNFVLPPPPIKKLVPRKV-VSRESAPIKEPKKLMPKTSLPTVKKLATATTGP 284
                +F D       PI KL PR + V  +  P+++             KKL   T  P
Sbjct: 218 -----IFKDK------PI-KLRPRSIEVENDFLPVEK----------TIGKKLPATTATP 255

Query: 285 SKAKT---SRTPSRDSQK----------------------LTSRDSGPNGGFQSGGSYHP 319
             +KT   SRT S+D  K                      L ++D    G ++   +   
Sbjct: 256 DSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN--- 312

Query: 320 GRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPA 379
           GR+        +      E+E + P K P      +     T ER    +  P  +    
Sbjct: 313 GRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML 372

Query: 380 PDKV-----PSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSII 434
           P++      P  E  L L  K S+P          P K P P K  +     ++P     
Sbjct: 373 PNRTEEKERPEREPKLDL-QKPSVPA--------IPPKKPRPPKTNSLSRPGALP----- 418

Query: 435 PEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEE 494
                    P  PER          ++P +D               +L  +L  +LS+  
Sbjct: 419 ---------PRRPERPVGPLTHTRGDSPKIDLA-----------GSSLSGILDKDLSDRS 458

Query: 495 VSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTL 554
               +DI    F S          V+  +  S      P+A   +PPS            
Sbjct: 459 ----NDIDLEGFDS---------VVSSTEKLSHPTTSRPKATGRRPPS------------ 493

Query: 555 VRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLRE 614
                   Q+   S  +S    + P P E+                +EE      R +  
Sbjct: 494 --------QSLTSSSLSSPDIFDSPSPEED----------------KEEHISLAHRGVDA 529

Query: 615 EVLPKEGVASKEEVTLKEELPPKEEV--------APKEEVPPIERAFAQKTRPIKP-PPD 665
                + V   +    K  LPPK           AP     P   + +  T   +   P 
Sbjct: 530 SKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPS 589

Query: 666 SQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSE 725
              T   P + P   ++       V  LR +V  LR  +E M+ Q +R++  +  EL  E
Sbjct: 590 LFGTEGKPKMEPAASSQ-----AAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEE 644

Query: 726 KEQRRRLEVQV 736
           K+ R RL+++V
Sbjct: 645 KKIRLRLQMEV 655


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score =  110 bits (276), Expect = 4e-24
 Identities = 124/494 (25%), Positives = 199/494 (40%), Gaps = 88/494 (17%)

Query: 240  PPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQK 299
            PP  K   P K  ++  A +K P+K   K+      K       P KAK+   P ++  K
Sbjct: 561  PPEAKS--PEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAKSPEKAKS---PVKEEAK 613

Query: 300  LTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQ-----RSVSSQEEEHSSPVKAPSVKRTP 354
              +    P        +     +++K+ T ++     ++ S ++EE  SP KA S    P
Sbjct: 614  SPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS----P 669

Query: 355  MPDKTATPERPPAPENA----PSSKKIPAPDKVPSPEKTLT-LGDKASIPGNSTSGKIPA 409
            +  +  +PE+  +P  A    P   K P  ++  SPEK  + + ++A  P  + S   P 
Sbjct: 670  VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKS---PV 726

Query: 410  PDKVPTPEKMVTP-EDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVP 468
             ++  TPEK  +P +++A  PE +  PE+  T+D  S   +  + EE+ +    P DK P
Sbjct: 727  KEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS----PADKFP 782

Query: 469  NPKMAPLGDEAPTLEKVLTP-----ELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKED 523
                +P+ +E  + EK  +P     +  E+E+  +++++      EE  Q+VK    KE 
Sbjct: 783  EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK-SPVKEEEKPQEVK---VKEP 838

Query: 524  PSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASR------PALE 577
            P   EE   P  P  +                + DS   +A  K  P  +      PA+E
Sbjct: 839  PKKAEEEKAPATPKTEE---------------KKDSKKEEAPKKEAPKPKVEEKKEPAVE 883

Query: 578  KPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGV--------------- 622
            KP   +      E        TPE+EAP   +  ++E+  PKE                 
Sbjct: 884  KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE--VKEDAKPKEKTEVAKKEPDDAKAKEP 941

Query: 623  --------ASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPD----SQETL 670
                    A+ E+   KEE   K E  PK E    E        P KP  +    S  T 
Sbjct: 942  SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001

Query: 671  ALPSLVPQNYTENK 684
               S  P+  TE+K
Sbjct: 1002 QKDSKPPEKATEDK 1015



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 111/449 (24%), Positives = 200/449 (44%), Gaps = 59/449 (13%)

Query: 325 KTQTPQQRSVSSQEEEHSSPV----KAPSVKRTPMPDKTATPERPPAPENA--PSSKKIP 378
           +T++P     +S E+E  SPV    K+P+  ++P  ++  +P    +PE A  P+ ++  
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559

Query: 379 APDKVPSPEKTLTLGDKASIPGNSTS---GKIPAPDKVPTPEKMVTPED-KASIPENSII 434
           +P +  SPEK     ++A  P    S    K PA ++  +P +  +PE  K+ + E +  
Sbjct: 560 SPPEAKSPEK-----EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKS 614

Query: 435 PEETLT--VDKPSTPERVFSVEESPALEAPPMDKVPNPKMA--PLGDEAPTLEKVLTPEL 490
           P E  +   ++  +P  V S E++   ++P  ++  +P+ A  P  +EA + EK  +P  
Sbjct: 615 PAEAKSPVKEEAKSPAEVKSPEKA---KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVK 671

Query: 491 SEEE--VSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLG 548
           +E +     +  ++    S E+A   V     KE+  S E+A +P     + P   +   
Sbjct: 672 AEAKSPEKAKSPVKAEAKSPEKAKSPV-----KEEAKSPEKAKSPVKEEAKSPEKAKSPV 726

Query: 549 EMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAP------SNDERTPEE 602
           + +        SP + E KS        EK    E+A TL  ++P        + R+P +
Sbjct: 727 KEEAKTPEKAKSPVKEEAKSP-------EKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779

Query: 603 EAPPNEQRPLREEV---------LPKEGVASKEEVTLKEEL--PPKEEVAPKE---EVPP 648
           + P   + P++EEV         L ++  A ++E+  KEE+  P KEE  P+E   + PP
Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPP 839

Query: 649 --IERAFAQKTRPIKPPPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLR-RALE 705
              E   A  T   +   DS++  A     P+   E K E         +VE+ +  A +
Sbjct: 840 KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED 899

Query: 706 LMEVQLERKLTDIWEELKSEKEQRRRLEV 734
             +V    K      E+K + + + + EV
Sbjct: 900 KKKVPTPEKEAPAKVEVKEDAKPKEKTEV 928



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 79/371 (21%), Positives = 145/371 (39%), Gaps = 58/371 (15%)

Query: 398 IPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESP 457
           IP  ST  K+ + +K+   EK        S  E  I+ E+T   ++    E V   EE  
Sbjct: 429 IPSVSTHIKVKSEEKIKVVEK--------SEKETVIVEEQT---EETQVTEEVTEEEEKE 477

Query: 458 ALEAPPMDKVPNPKMAPLGDE----APTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQ 513
           A E    ++    +    G E    +P  E+  +PE                   +EA  
Sbjct: 478 AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPE-------------------KEAKS 518

Query: 514 KVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASR 573
            VK     E+  S  EA +PE    + P+  +   + K        SP +A+      ++
Sbjct: 519 PVK-----EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAK 573

Query: 574 PALEKPHPHEEATTLPEEAPSNDE-RTPEE---------EAPPNEQRPLREEVLPKEGVA 623
              E   P +  +   EEA S  E ++PE+         ++P   + P++EE      V 
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVK 633

Query: 624 SKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQNYTEN 683
           S E    K + P KEE    E+    E+  A+     K P  ++      +  P    E 
Sbjct: 634 SPE----KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVK-AEA 688

Query: 684 KNEGVDVTSLRGEVESLRRALELMEVQL---ERKLTDIWEELKSEKEQRRRLEVQVMQGT 740
           K+     + ++ E +S  +A   ++ +    E+  + + EE K+ ++ +  ++ +  +  
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA-KSP 747

Query: 741 QKSQTPRVIHT 751
           +K+++P    T
Sbjct: 748 EKAKSPEKAKT 758


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score =  100 bits (249), Expect = 5e-21
 Identities = 145/627 (23%), Positives = 235/627 (37%), Gaps = 88/627 (14%)

Query: 108   EIVEMIK----EIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPP 163
             E+ E IK     +E+   + K +  +  F +  VE+ +        P++      P++PP
Sbjct: 10397 EVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEKIIPPKKPP 10456

Query: 164   KLSSLAYDSPPDYLQTVSHPEV-YRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWE 222
                 +    PP  +     PEV  +++ + +   P+E  +    V +VL          E
Sbjct: 10457 T-KVVPRKEPPAKV-----PEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPPK-------E 10503

Query: 223   GECQGRRGVFPDNFVLPPPPIKKLVPRKVVSRESAPIKEPKKL-MPKTSLPTVKKLATAT 281
                + +  V P      PPP     P++VV  +  P+  PKK  +P T +P V K A   
Sbjct: 10504 VVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAV-- 10561

Query: 282   TGPSKAKTSRTPSRDSQKLTSRDSGPNGGF-QSGGSYHPGRKRSKT--QTPQQ-RSVSSQ 337
               P K      P +           P     +      P +K   T  + P+  + V  +
Sbjct: 10562 --PEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVPEAPKEVVPE 10619

Query: 338   EEEHSSPVKAPSVKRTPMPD--KTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDK 395
             ++    P K P V  T +P+  K A PE+   PE  P   + P P+    PE+       
Sbjct: 10620 KKVPVPPPKKPEVPPTKVPEVPKVAVPEKK-VPEAIPPKPESPPPEVFEEPEEVALEEPP 10678

Query: 396   ASI---PGNSTSGKIPAPDKVPTPEKMVT------PE-DKASIPE--NSIIPEETLTVDK 443
             A +   P  +   ++  P K P PEK         PE     +PE    ++PE+ + +  
Sbjct: 10679 AEVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVV 10738

Query: 444   PSTPERVFSVEESPALEAPPMDKVPNPKM-------APLGDEAPTLEKVLTPELSEEEVS 496
             P  PE   +       E  P  KV  PK         P   + P LE+     + E   S
Sbjct: 10739 PKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAES 10798

Query: 497   TRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSS-ERCLGEMKCTLV 555
                ++   +   EE   + +    +E P    E   PE PPP  P   ++ + E K  ++
Sbjct: 10799 PPPEV---YEEPEEIAPEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVI 10855

Query: 556   RGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERT--------PEEEAPPN 607
             +   +P   E    P     +EKP         P   P  D +         P+++ P  
Sbjct: 10856 KKPEAPPPKE----PEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPKKKVPEK 10911

Query: 608   EQRPLREEV---------------LPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERA 652
              Q P + E+               LP+     KEEV LK  L  +    P+EE P +E  
Sbjct: 10912 PQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKR----PEEEEPKVEPK 10967

Query: 653   FAQKTR----PIKPPPDSQETLALPSL 675
               +K +    P  PPP   E + +P++
Sbjct: 10968 KLEKVKKPAVPEPPPPKPVEEVEVPTV 10994



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 106/437 (24%), Positives = 170/437 (38%), Gaps = 79/437 (18%)

Query: 239   PPPPIKKLVPRKVVSRESAPIKEPKKL-MPKTSLPTVKKLATATTG---PSKAKTSRTPS 294
             PPP     VP+K V  E  P+  PKK+  P   +P V K          P+  K    P+
Sbjct: 9999  PPPAKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPPA 10058

Query: 295   RDSQ---KLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVK 351
             +  +   KL   +  P                    TP  + V +       P K P  K
Sbjct: 10059 KVPEVPKKLIPEEKKP--------------------TPVPKKVEAP------PPKVPK-K 10091

Query: 352   RTPMPDKTATPERPPA---PENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIP 408
             R P+P   A P+        E  P  + +P  ++V   E+ +   ++  +P      +IP
Sbjct: 10092 REPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEE---EIP 10148

Query: 409   APDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPS---------TPERVF--SVEESP 457
               ++   PE+   PE++  +PE  ++PE    V  P+         T ++V     EE+P
Sbjct: 10149 PEEEEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAP 10208

Query: 458   ALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKY 517
               + P + K    K   L  E   L   +T E  EE +S  +                  
Sbjct: 10209 PAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEE------------------ 10250

Query: 518   FVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASR---P 574
              + +E PS +E      APP  P   ++ + E    + +   +P     K  P  +   P
Sbjct: 10251 -IPEEPPSIEEVEEV--APPRVPEVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVP 10307

Query: 575   ALEKPHPHEEATTLPEEAPSNDERTPEEEA-PPNEQRPLREEVLPKEGVASKEEVTLKEE 633
               +K  P  +   +P++ P      P++EA PP + R + EE   K  VA ++EV +KE 
Sbjct: 10308 VQKKEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEE---KVSVAFRQEVVVKER 10364

Query: 634   LPPKEEVAPKEEVPPIE 650
             L  +   A  EE+P  E
Sbjct: 10365 LELEVVEAEVEEIPEEE 10381



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 122/509 (23%), Positives = 185/509 (36%), Gaps = 104/509 (20%)

Query: 241   PPIKKLVPRK-VVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQK 299
             PP K    RK VV  E   I+ PK+       P   K  T      +A T    +   Q+
Sbjct: 9688  PPAKVTEFRKRVVKEEKVSIEAPKRE------PQPIKEVTIMEEKERAYTLEEEAVSVQR 9741

Query: 300   LTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEE------EHSSPVKAPSVKRT 353
                 +      ++    Y P  +  + +  ++R     EE      E   P+    V   
Sbjct: 9742  EEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEE 9801

Query: 354   PMPDKTATPERPPA-------PEN---APSSKKI-PAPDKVPSPEK---------TLTLG 393
             P+P K   P+ PPA       PE     P  KK+ P P KVP   K         ++T  
Sbjct: 9802  PVPTK---PKAPPAKVLKKAVPEEKVPVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKR 9858

Query: 394   DKASIPGNSTSGKIP-------APDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPST 446
             +K  +     + K+P       A +KVP P K V P  +       + PEE    ++  T
Sbjct: 9859  EKEQV--TEPAAKVPMKPKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVT 9916

Query: 447   PERVFSVEES------------------------PALEAPPMDKVPNPKMAPLGDEAPTL 482
                 + VEE                         P +   P+ +   P   P   EAP  
Sbjct: 9917  HVEEYLVEEEEEYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPA 9976

Query: 483   EKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTP-----EAPP 537
             +    P+  EE+V             +E     K     + P  +E+   P     EAPP
Sbjct: 9977  KVPEVPKKPEEKVPVL-------IPKKEKPPPAKVPEVPKKPVPEEKVPVPVPKKVEAPP 10029

Query: 538   PQPPS-SERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSND 596
              + P   ++ + E K  +      P   ++++ PA  P + K    EE    P       
Sbjct: 10030 AKVPEVPKKPVPEKKVPV------PAPKKVEAPPAKVPEVPKKLIPEEKKPTP------- 10076

Query: 597   ERTPEE-EAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVAP-KEEVPPIERAFA 654
                P++ EAPP +    RE V     +  +EEV  +EE+ P+EEV P +EEV P E    
Sbjct: 10077 --VPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVL 10134

Query: 655   QKTRPIKP-----PPDSQETLALPSLVPQ 678
              +   + P     PP+ +E       VP+
Sbjct: 10135 PEEEEVLPEEEEIPPEEEEVPPEEEYVPE 10163



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 97/349 (27%), Positives = 143/349 (40%), Gaps = 81/349 (23%)

Query: 330   QQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKT 389
             ++  ++ +E     PVK P V R P+P+     E+ P P   P  K+ P P KVP   K 
Sbjct: 9933  EEEFITEEEVVPVIPVKVPEVPRKPVPE-----EKKPVP--VPKKKEAP-PAKVPEVPKK 9984

Query: 390   LTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPER 449
                  +  +P      + P P KVP   K   PE+K  +P    +P++   V+ P  P +
Sbjct: 9985  ----PEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVP----VPKK---VEAP--PAK 10031

Query: 450   VFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSE 509
             V  V + P     P  KVP P  AP   EAP  +    PE+ ++ +              
Sbjct: 10032 VPEVPKKPV----PEKKVPVP--APKKVEAPPAK---VPEVPKKLI-------------- 10068

Query: 510   EALQKVKYFVAKEDPSSQEEAHTP---EAPPPQPPSSER------CLGEMKCTLVRGDSS 560
                           P  ++    P   EAPPP+ P           L + +  L   +  
Sbjct: 10069 --------------PEEKKPTPVPKKVEAPPPKVPKKREPVPVPVALPQEEEVLFEEEIV 10114

Query: 561   PRQAELKSGPASRPALEKPHPHEEATTLPEEA---PSNDERTPEEEAPPNEQRPLREE-- 615
             P +  L       P  E+  P EE   LPEE    P  +E  PEEE  P E+  + EE  
Sbjct: 10115 PEEEVLPEEEEVLPEEEEVLPEEEEV-LPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEV 10173

Query: 616   ---VLPKEGVAS-----KEEVTLKEELPPKEEVAPKEEVPPIERAFAQK 656
                V PK  V +     K++VT K+ + PK+E AP  +VP + +   +K
Sbjct: 10174 LPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEK 10222



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 135/593 (22%), Positives = 210/593 (35%), Gaps = 114/593 (19%)

Query: 150   PDMPSVSPGPQR----PPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
             P+    +P P++    PPK+       P      V+ P+   VLF+ +    +E+     
Sbjct: 10069 PEEKKPTPVPKKVEAPPPKVPKKREPVPVP----VALPQEEEVLFEEEIVPEEEVLPEEE 10124

Query: 206   DVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP-----PPIKKLVPRK---VVSRESA 257
             +V+    +   ++            V P+   +PP     PP ++ VP +   V   E  
Sbjct: 10125 EVLPEEEEVLPEE----------EEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEEEVL 10174

Query: 258   PIKEPKKLMPKTSLPTVKKLATA--TTGPSK-----AKTSRTPSRDSQKLTSRDSGPNGG 310
             P  +PK  +P   +P +KK  T      P K     AK    P +  +K           
Sbjct: 10175 PEVKPKVPVP-APVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKKVEEKRIILPKEEEV- 10232

Query: 311   FQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDK-TATPERPPAPE 369
                  +  P  +    +   +   S +E E  +P + P V +  +P+  T  P++  AP 
Sbjct: 10233 LPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPRVPEVIKKAVPEAPTPVPKKVEAPP 10292

Query: 370   NAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIP 429
              A  SKKIP  +KVP P +                 K   P KVP   K V PE K  +P
Sbjct: 10293 -AKVSKKIPE-EKVPVPVQK----------------KEAPPAKVPEVPKKV-PEKKVLVP 10333

Query: 430   ENSIIPE---ETLTVDKPSTPERV-FSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKV 485
             +   +P     T+  +K S   R    V+E   LE    +    P+     +     E  
Sbjct: 10334 KKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVVEAEVEEIPEEEEFHEVEEYFE-- 10391

Query: 486   LTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSER 545
                E    EV     ++ H    E  ++KV   +   +    E    P+APP  P  SE+
Sbjct: 10392 ---EGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEVEVFEKPKAPPKGPEISEK 10448

Query: 546   CLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPE---- 601
              +   K          +    K  PA  P + K    EE   +PEE      + PE    
Sbjct: 10449 IIPPKK-------PPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRVPPTKVPEVLPP 10501

Query: 602   ----------------EEAPPNEQRPLREEVLPKEGV--------------------ASK 625
                              EAPP +     +EV+P++ V                    A+ 
Sbjct: 10502 KEVVPEKKVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAV 10561

Query: 626   EEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQ 678
              E  + E +PPK E  P E     +    +K  P  PP   + T   P  VP+
Sbjct: 10562 PEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVT---PVKVPE 10611



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 112/480 (23%), Positives = 175/480 (36%), Gaps = 84/480 (17%)

Query: 239  PPPP--IKKLVPRKV--VSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPS 294
            PPPP  IKK V  K+   SR     K     +P+ S   V +  + T    +    + P+
Sbjct: 9175 PPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIVPQKPSRTPVQEEVIEVKVPA 9234

Query: 295  RDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTP 354
              ++K+   +       +   + H   + S T    Q+ + ++E+ H     A S +  P
Sbjct: 9235 VHTKKMVISEE------KMFFASHTEEEVSVTVPEVQKEIVTEEKIHV----AISKRVEP 9284

Query: 355  MPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIP-----A 409
             P     PE+P   E AP    +P P KV  P   +    K  +P       +P     A
Sbjct: 9285 PPKVPELPEKPAPEEVAP----VPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAA 9340

Query: 410  PDKVPTPEKMVTPEDKASIP---ENSIIPEETLTVDKPSTPERVFSV----EESPALEAP 462
            P KVP   K   PE+K  +P   +    P +   V K    E   ++    EESP    P
Sbjct: 9341 PPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPP---P 9397

Query: 463  PMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKE 522
             + ++P  K+       P  E+ + P                         KV     K 
Sbjct: 9398 AVPEIPKKKVPEERKPVPRKEEEVPPP-----------------------PKVPALPKKP 9434

Query: 523  DPSSQEEAHTP---EAPPPQPPSSERCLGEMKCTLVRGDSS---PRQAELKSGPASRPAL 576
             P  +     P   +APPP+   S++ + E K  +     S   P++ E+     S  A 
Sbjct: 9435 VPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVS--AE 9492

Query: 577  EKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLRE----------EVLPKEGVASKE 626
            E+    EE   +       +ER  EEEA   E   + E           ++ K   A   
Sbjct: 9493 EEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPA 9552

Query: 627  EVT--------LKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQ 678
            EVT        LK ++P K E  P  +VP   +    + +   P P  ++    P  VP+
Sbjct: 9553 EVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPAPVPKKEK--VPPPKVPE 9610



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 102/457 (22%), Positives = 165/457 (36%), Gaps = 78/457 (17%)

Query: 237  VLPPPPIKKLVPRKVVSRESAPIKEPKKLMPKT-SLPTVKKLATATTGPSKAKTSRTPSR 295
            V PPP + +L P K    E AP+  PKK+ P    +P V K       P + K    P +
Sbjct: 9282 VEPPPKVPEL-PEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPV----PEEKKPVPVPKK 9336

Query: 296  DSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQR-SVSSQEEEHSSPVKAPSVKRTP 354
            +          P                 K   P+++  V   +++ + P K P V++  
Sbjct: 9337 EPAAPPKVPEVP-----------------KKPVPEEKIPVPVAKKKEAPPAKVPEVQKGV 9379

Query: 355  MPDK-----TATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPA 409
            + ++     T   E PP        KK+P  ++ P P K                 ++P 
Sbjct: 9380 VTEEKITIVTQREESPPPAVPEIPKKKVP-EERKPVPRK---------------EEEVPP 9423

Query: 410  PDKVPTPEKMVTPEDKASIP---ENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDK 466
            P KVP   K   PE+K ++P        P       K    E+ F  EE  +   P   +
Sbjct: 9424 PPKVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVE 9483

Query: 467  VPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSS 526
            V   +++   + +           SEEE      +       EE   +V  +   E+P  
Sbjct: 9484 VTRHEVSAEEEWS----------YSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEE 9533

Query: 527  ---QEEAH----TPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGP---ASRPAL 576
               +E+ H      EA P +    +     +K  +      P  A++   P        +
Sbjct: 9534 YVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKV 9593

Query: 577  EKPHPHEEATTLPEEAPSNDERTPEEEAPP---NEQRPLREEVLPKEGVASKEEVTL--- 630
              P P +E    P+      +  PE++ PP     + PL  +V  +    ++EE  L   
Sbjct: 9594 PAPVPKKEKVPPPKVPEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAV 9653

Query: 631  -KEELPPKEEV--APKEEVPPIERAFAQKTRPIKPPP 664
             K+E PPK  V   PK  VP  E+    K +  + PP
Sbjct: 9654 TKKEAPPKARVPEEPKRAVPE-EKVLKLKPKREEEPP 9689



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 124/540 (22%), Positives = 197/540 (36%), Gaps = 124/540 (22%)

Query: 237  VLPPPPIKKLVPRKVVSRESAPIKEPKKL---------MPKTSLPTVKKLATATTGPSKA 287
            V PP P    VP+K V  E  P+  PKK          +PK  +P  +K+        +A
Sbjct: 9309 VEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPEVPKKPVPE-EKIPVPVAKKKEA 9367

Query: 288  KTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKR-SKTQTPQQRS-VSSQEEEHSSPV 345
              ++ P  + QK    +       Q   S  P      K + P++R  V  +EEE   P 
Sbjct: 9368 PPAKVP--EVQKGVVTEEKITIVTQREESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPP 9425

Query: 346  KAPSVKRTPMP-DKTATP----ERPPAPENAPSSKKIPAPDKVPSPEK-TLTLGDKASIP 399
            K P++ + P+P +K A P    ++ P P    S K +    +  + EK +  +  +  + 
Sbjct: 9426 KVPALPKKPVPEEKVAVPVPVAKKAPPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVT 9485

Query: 400  GNSTSGK-----------------------------------IPAPDKVPTPEKM----- 419
             +  S +                                   +  P++    EK+     
Sbjct: 9486 RHEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISK 9545

Query: 420  --------VTPEDKASIPENSIIP---EETLTVDKPSTPERVFSVEESPALEAPPMDKVP 468
                    VT   +  I     IP   EE      P  P+++   ++ PA   P  +KVP
Sbjct: 9546 RVEAEPAEVTERQEKKIVLKPKIPAKIEEPPPAKVPEAPKKIVPEKKVPA-PVPKKEKVP 9604

Query: 469  NPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQE 528
             PK+ P   + P  EK + P++ + E      +   H    +  Q+ K  VA     +  
Sbjct: 9605 PPKV-PEEPKKPVPEKKVPPKVIKMEEPLPAKVTERHM---QITQEEKVLVAVTKKEAPP 9660

Query: 529  EAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSP------RQAELKSGPASRPALEK-PHP 581
            +A  PE P    P  +     +K    R +  P      R+  +K    S  A ++ P P
Sbjct: 9661 KARVPEEPKRAVPEEK----VLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKREPQP 9716

Query: 582  HEEAT---------TLPEEAPS--NDERTPE---------EEAPPNEQRPLREEVLPK-- 619
             +E T         TL EEA S   +E   E         EE  P E+    EE   +  
Sbjct: 9717 IKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQYEEYEEREY 9776

Query: 620  EGVASKEEVTLKEELP------PKEEVAPKEEVPP---IERAFAQKTRPI------KPPP 664
            E     EE   + E P      P+E V  K + PP   +++A  ++  P+      KPPP
Sbjct: 9777 ERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVPIPKKLKPPP 9836



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 104/441 (23%), Positives = 175/441 (39%), Gaps = 51/441 (11%)

Query: 331  QRSVSSQEEEHSSPVKAPSVKRTPMPDKTATP--ERPPAPENAPSSKKIPAPDKVPSPEK 388
            Q+ V  +  E   P K P  K  P P     P  E+          +K+    KVP   K
Sbjct: 9153 QKEVYEESHERKVPAKVPEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQV-TKVPEVSK 9211

Query: 389  TLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPE 448
             +     +  P      ++  P      +KMV  E+K     ++   EE ++V  P   +
Sbjct: 9212 KIVPQKPSRTPVQEEVIEVKVP--AVHTKKMVISEEKMFFASHT---EEEVSVTVPEVQK 9266

Query: 449  RVFSVEE-----SPALEAPPMDKVPNPKMAPLGDE---APTLEKVLTPELSEEEVSTR-- 498
             + + E+     S  +E PP  KVP     P  +E    P  +KV  P     EV  +  
Sbjct: 9267 EIVTEEKIHVAISKRVEPPP--KVPELPEKPAPEEVAPVPIPKKVEPPAPKVPEVPKKPV 9324

Query: 499  -DDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTP-----EAPPPQPPSSER-CLGEMK 551
             ++ +      +E     K     + P  +E+   P     EAPP + P  ++  + E K
Sbjct: 9325 PEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEK 9384

Query: 552  CTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRP 611
             T+V       Q E +S P + P + K    EE   +P +         EEE PP  + P
Sbjct: 9385 ITIV------TQRE-ESPPPAVPEIPKKKVPEERKPVPRK---------EEEVPPPPKVP 9428

Query: 612  -LREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETL 670
             L ++ +P+E VA    V  K+  PP+ EV+ K+ V   +R  A++      P   + T 
Sbjct: 9429 ALPKKPVPEEKVAVPVPVA-KKAPPPRAEVS-KKTVVEEKRFVAEEKLSFAVPQRVEVTR 9486

Query: 671  ALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEKEQ-- 728
               S   +     + EGV ++  R E        E+ E ++   + +  E +  EK    
Sbjct: 9487 HEVSAEEEWSYSEEEEGVSISVYREEEREEEEEAEVTEYEV---MEEPEEYVVEEKLHII 9543

Query: 729  RRRLEVQVMQGTQKSQTPRVI 749
             +R+E +  + T++ +   V+
Sbjct: 9544 SKRVEAEPAEVTERQEKKIVL 9564



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 135/594 (22%), Positives = 211/594 (35%), Gaps = 126/594 (21%)

Query: 231   VFPDNFVLPPPPIK-KLVPRKVVSRESAPIKEPKKLMPKT----------------SLPT 273
             + P+  V  P P K K+ P KV      P+ E KK+ PK                  +  
Sbjct: 9587  IVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPE-KKVPPKVIKMEEPLPAKVTERHMQITQ 9645

Query: 274   VKKLATATT---GPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKR------- 323
              +K+  A T    P KA+    P R   +       P    +        RKR       
Sbjct: 9646  EEKVLVAVTKKEAPPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKV 9705

Query: 324   ---------------------SKTQTPQQRSVSSQEEEHSSPVKAPSVK----------- 351
                                   +  T ++ +VS Q EE     +    K           
Sbjct: 9706  SIEAPKREPQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEY 9765

Query: 352   ------------RTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIP 399
                         R    ++  T    P P      + +P   K P P K L    K ++P
Sbjct: 9766  DQYEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAP-PAKVL----KKAVP 9820

Query: 400   GNSTSGKIPAPDKVPTPEKMVTPEDKASIPEN---SIIPEETLTVDKPST-----PERVF 451
                    +P P K+  P   V  E K    E    SI   E   V +P+      P+RV 
Sbjct: 9821  EEKV--PVPIPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVV 9878

Query: 452   SVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPE--LSEEEVSTRDDIQFHHFSSE 509
             + E+ P         VP  ++AP     P + K L PE    EEEV T  + ++     E
Sbjct: 9879  AEEKVP---------VPRKEVAP-PVRVPEVPKELEPEEVAFEEEVVTHVE-EYLVEEEE 9927

Query: 510   EALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCL---GEMKCTLVRGDSSPRQAEL 566
             E + + + F+ +E+         PE P    P  ++ +    + +    +    P++ E 
Sbjct: 9928  EYIHEEEEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEE 9987

Query: 567   KSGPASRPALEKPHPHEEATTLPE--EAPSNDERTPEEEAPPNEQRPLREEVLPKEGVAS 624
             K  P   P  EKP P      +PE  + P  +E+ P       E  P +   +PK+ V  
Sbjct: 9988  KV-PVLIPKKEKPPP----AKVPEVPKKPVPEEKVPVPVPKKVEAPPAKVPEVPKKPVPE 10042

Query: 625   KEEVTLKEELP-PKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQNYTEN 683
             K     K  +P PK+  AP  +VP + +    + +  KP P  ++  A P  VP+     
Sbjct: 10043 K-----KVPVPAPKKVEAPPAKVPEVPKKLIPEEK--KPTPVPKKVEAPPPKVPK----- 10090

Query: 684   KNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEKEQRRRLEVQVM 737
             K E V V     + E +   L   E+  E ++    EE+  E+E+    E +V+
Sbjct: 10091 KREPVPVPVALPQEEEV---LFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVL 10141



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 52/242 (21%), Positives = 94/242 (38%), Gaps = 20/242 (8%)

Query: 260   KEPKKLMPKTSLPTVKKL-ATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYH 318
             +EPKK++P+  +P +KK  A     P   K    P    +      + P    +      
Sbjct: 10841 EEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKE--KIF 10898

Query: 319   PGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKI- 377
               +   K + P++  V  + E   +P+K P  ++     +   PER P P+     K + 
Sbjct: 10899 QLKAIPKKKVPEKPQVPEKVE--LTPLKVPGGEKKV---RKLLPERKPEPKEEVVLKSVL 10953

Query: 378   ---PAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSII 434
                P  ++     K L    K ++P      + P P  V   E     + +  IPE + +
Sbjct: 10954 RKRPEEEEPKVEPKKLEKVKKPAVP------EPPPPKPVEEVEVPTVTKRERKIPEPTKV 11007

Query: 435   PEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEE 494
             PE    +  P+   +     E   ++ PP++  P P  AP+    P + K    +  +EE
Sbjct: 11008 PEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPV--TVPVVGKKAEAKAPKEE 11065

Query: 495   VS 496
              +
Sbjct: 11066 AA 11067



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 86/412 (20%), Positives = 136/412 (33%), Gaps = 100/412 (24%)

Query: 355  MPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNSTSGKIPAPDKVP 414
            MP +   PE  P     P    +P P++   P K + +  KA       + K+ A  K  
Sbjct: 8947 MPIRAVPPEEIPPVVAPPIPLLLPTPEEKKPPPKRIEVTKKAV---KKDAKKVVAKPKEM 9003

Query: 415  TPEKMVTPEDKASIPENSIIPEE-----------------TLTVDKPSTPERVFSVEESP 457
            TP + +    K   P  ++IP +                 T+T  K    E+    E+  
Sbjct: 9004 TPREEIV---KKPPPPTTLIPAKAPEIIDVSSKAEEVKIMTITRKKEVQKEKEAVYEKKQ 9060

Query: 458  AL-----------EAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHF 506
            A+           E P  +    P   P   E P  E+   P+   EE+      + H  
Sbjct: 9061 AVHKEKRVFIESFEEPYDELEVEPYTEPF--EQPYYEE---PDEDYEEIKVEAKKEVHEE 9115

Query: 507  SSEEALQKVKYFVAKEDPSSQEE----------------------------AHTPEAPPP 538
              E+  +  +Y+  +E     EE                            A  PE   P
Sbjct: 9116 WEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKVPEKKAP 9175

Query: 539  QPP------------SSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEK------PH 580
             PP             + R + E K  + +     ++  +   P+  P  E+      P 
Sbjct: 9176 PPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKI-VPQKPSRTPVQEEVIEVKVPA 9234

Query: 581  PHEEATTLPEEAPSNDERTPEE---EAPPNEQRPLREE---VLPKEGVASKEEVTLKEEL 634
             H +   + EE       T EE     P  ++  + EE   V   + V    +V    E 
Sbjct: 9235 VHTKKMVISEEKMFFASHTEEEVSVTVPEVQKEIVTEEKIHVAISKRVEPPPKVPELPEK 9294

Query: 635  PPKEEVA----PKEEVPPIERAFAQKTRPI----KPPPDSQETLALPSLVPQ 678
            P  EEVA    PK+  PP  +      +P+    KP P  ++  A P  VP+
Sbjct: 9295 PAPEEVAPVPIPKKVEPPAPKVPEVPKKPVPEEKKPVPVPKKEPAAPPKVPE 9346


>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
          Length = 731

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 70/241 (29%), Positives = 107/241 (44%), Gaps = 25/241 (10%)

Query: 4   LVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ---EIPETL 60
           +VL  + A++ D+L+L  G++V  +  +    W RG    + G+FP   V+   +IPE  
Sbjct: 442 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDT-DWYRGNCRNQIGIFPANYVKVIIDIPEGG 500

Query: 61  RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
            G  E     C +              C   F Y  EQ DEL    GEI+ + + + + W
Sbjct: 501 NGKRECVSSHCVKGSR-----------CVARFEYIGEQKDELSFSEGEIIILKEYVNEEW 549

Query: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
             G+  G+ G FP NFVE ++  P S  N     V    ++    S+   +S P      
Sbjct: 550 ARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP------ 603

Query: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240
              E    L  +  E  D+L+ +RGD +++L +   D  W  G  Q R G+FP  FV P 
Sbjct: 604 --AEWCEALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRLQDREGIFPAVFVRPC 659

Query: 241 P 241
           P
Sbjct: 660 P 660



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 38/235 (16%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           Y  +++DELS + G+++    +V    W RGE  GR G+FP   V+ + +          
Sbjct: 523 YIGEQKDELSFSEGEIIILKEYVNEE-WARGEVRGRTGIFPLNFVEPVEDYPTSGANVLS 581

Query: 69  PRCARRR------GHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWL 122
            +   +        +   +  P  WC+   S++ E +D+L  + G+ +++++ ++  W  
Sbjct: 582 TKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 641

Query: 123 GKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSH 182
           G+   + G FP+ FV                   P P     +           L  V  
Sbjct: 642 GRLQDREGIFPAVFVR------------------PCPAEAKSM-----------LAIVPK 672

Query: 183 PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
               + L+D++ E  DEL+ + GD++  L    +D  W  GE  G+ G+FP N++
Sbjct: 673 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD--WMSGELMGKSGIFPKNYI 725



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 16/135 (11%)

Query: 6   LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGE 65
           L  + A+  D+LS   GD ++ +  + +  W RG    R G+FP   V+  P       E
Sbjct: 610 LHSFTAETSDDLSFKRGDRIQILERLDS-DWCRGRLQDREGIFPAVFVRPCP------AE 662

Query: 66  ARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
           A+       +G  AK           + +  E  DEL  +AG+I+  ++ ++D W  G+ 
Sbjct: 663 AKSMLAIVPKGRKAK---------ALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL 713

Query: 126 NGQLGAFPSNFVELL 140
            G+ G FP N+++ L
Sbjct: 714 MGKSGIFPKNYIQFL 728



 Score = 37.7 bits (86), Expect = 0.040
 Identities = 70/332 (21%), Positives = 114/332 (34%), Gaps = 44/332 (13%)

Query: 269 TSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQT 328
           + LP   ++   +  P    +S  PS   +   +R SG    + SG          +  T
Sbjct: 29  SGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGE---WDSGTENRLKVTSKEGLT 85

Query: 329 PQQRSVSSQEEEHSSPVKAPSVKRTPMPD--KTATPERP---PAPENAPSSKKIPAPDKV 383
           P        +E  S PV  P + + P P   ++  PE P   P  E++ S KK+P P   
Sbjct: 86  PYP----PLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPR 141

Query: 384 P----------------SPEKTLTLGDKASIPGNSTSGKI-----PAPDKVPT-PEKMVT 421
           P                +P K +T+  + +    + + K      PA   VP    K + 
Sbjct: 142 PLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLV 201

Query: 422 PEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPT 481
             D  S  ++ +        ++    E V  + E P  ++PP    P P   P+G+   T
Sbjct: 202 DIDLISFDDDVLPTPSGNLAEESVGSEMVLGLHEDP--QSPP----PLPAEKPIGNTFST 255

Query: 482 LEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPP 541
           +   L+       + +    Q   F         +    K  P+ Q     P   PP P 
Sbjct: 256 VSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPK 315

Query: 542 SSERCLGEMKCTLVRG----DSSPRQAELKSG 569
            S       K    R     D   +Q+ L +G
Sbjct: 316 LSATRRSNKKLPFNRSSSDMDLQKKQSNLATG 347


>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
          Length = 767

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 70/241 (29%), Positives = 107/241 (44%), Gaps = 25/241 (10%)

Query: 4   LVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ---EIPETL 60
           +VL  + A++ D+L+L  G++V  +  +    W RG    + G+FP   V+   +IPE  
Sbjct: 478 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDT-DWYRGNCRNQIGIFPANYVKVIIDIPEGG 536

Query: 61  RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
            G  E     C +              C   F Y  EQ DEL    GEI+ + + + + W
Sbjct: 537 NGKRECVSSHCVKGSR-----------CVARFEYIGEQKDELSFSEGEIIILKEYVNEEW 585

Query: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
             G+  G+ G FP NFVE ++  P S  N     V    ++    S+   +S P      
Sbjct: 586 ARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP------ 639

Query: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240
              E    L  +  E  D+L+ +RGD +++L +   D  W  G  Q R G+FP  FV P 
Sbjct: 640 --AEWCEALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRLQDREGIFPAVFVRPC 695

Query: 241 P 241
           P
Sbjct: 696 P 696



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 38/235 (16%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           Y  +++DELS + G+++    +V    W RGE  GR G+FP   V+ + +          
Sbjct: 559 YIGEQKDELSFSEGEIIILKEYVNEE-WARGEVRGRTGIFPLNFVEPVEDYPTSGANVLS 617

Query: 69  PRCARRR------GHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWL 122
            +   +        +   +  P  WC+   S++ E +D+L  + G+ +++++ ++  W  
Sbjct: 618 TKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 677

Query: 123 GKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSH 182
           G+   + G FP+ FV                   P P     +           L  V  
Sbjct: 678 GRLQDREGIFPAVFVR------------------PCPAEAKSM-----------LAIVPK 708

Query: 183 PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
               + L+D++ E  DEL+ + GD++  L    +D  W  GE  G+ G+FP N++
Sbjct: 709 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD--WMSGELMGKSGIFPKNYI 761



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 16/135 (11%)

Query: 6   LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGE 65
           L  + A+  D+LS   GD ++ +  + +  W RG    R G+FP   V+  P       E
Sbjct: 646 LHSFTAETSDDLSFKRGDRIQILERLDS-DWCRGRLQDREGIFPAVFVRPCP------AE 698

Query: 66  ARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
           A+       +G  AK           + +  E  DEL  +AG+I+  ++ ++D W  G+ 
Sbjct: 699 AKSMLAIVPKGRKAK---------ALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL 749

Query: 126 NGQLGAFPSNFVELL 140
            G+ G FP N+++ L
Sbjct: 750 MGKSGIFPKNYIQFL 764



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 56/233 (24%), Positives = 93/233 (39%), Gaps = 38/233 (16%)

Query: 238 LPPPPIKKLVPRKVVSRE-----SAPIKE---PKKLMPKTSLPTVKKLATAT-TGPSKAK 288
           +P P  + L+ +K VS E     SAP+K    P +L   +     K L       P    
Sbjct: 135 VPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPV 194

Query: 289 TSRTPSRDSQKLTSRDS---GPNGGF--QSGGS---YHPGRKRSKTQTPQQRSVSSQEEE 340
               P  D   ++  D     P+G    +S GS     P +  +KT+  ++R+V      
Sbjct: 195 LQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQP---- 250

Query: 341 HSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKI-----PAPDKVPSPEKTLTLGDK 395
             +P + P+V R P        E P +P   P+ K I         K+ + E+T  L  +
Sbjct: 251 --APTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNL--E 306

Query: 396 ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPE 448
           ++ PG  T G +  P ++P       P +  +IP     P   +  ++P  P+
Sbjct: 307 SNHPG-QTGGFVRVPPRLPP-----RPVNGKTIPTQQ--PPTKVPPERPPPPK 351



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 71/362 (19%), Positives = 108/362 (29%), Gaps = 68/362 (18%)

Query: 269 TSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQT 328
           + LP   ++   +  P    +S  PS   +   +R SG    + SG          +  T
Sbjct: 29  SGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGE---WDSGTENRLKVTSKEGLT 85

Query: 329 PQQRSVSSQEEEHSSPVKAPSVKRTPMPD--KTATPERP---PAPENAPSSKKIPAPDKV 383
           P        +E  S PV  P + + P P   ++  PE P   P  E++ S KK+P P   
Sbjct: 86  PYP----PLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPR 141

Query: 384 PSPEKTLTLGDKASIP-------------------------GNSTSGKIPAP-------- 410
           P   K     +  + P                         G       P P        
Sbjct: 142 PLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLV 201

Query: 411 ---------DKVPTPEKMVTPE--------DKASIPENSIIPEETLTVDKPSTPERVFSV 453
                    D +PTP   +  E        D   +P  +   +E      P+    V  +
Sbjct: 202 DIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRI 261

Query: 454 EESP--ALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEA 511
              P   L   P    P P   P+G+   T+   L+       + +    Q   F     
Sbjct: 262 PAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPP 321

Query: 512 LQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRG----DSSPRQAELK 567
               +    K  P+ Q     P   PP P  S       K    R     D   +Q+ L 
Sbjct: 322 RLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLA 381

Query: 568 SG 569
           +G
Sbjct: 382 TG 383


>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
          Length = 790

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 70/241 (29%), Positives = 107/241 (44%), Gaps = 25/241 (10%)

Query: 4   LVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ---EIPETL 60
           +VL  + A++ D+L+L  G++V  +  +    W RG    + G+FP   V+   +IPE  
Sbjct: 501 VVLHDFPAEQVDDLNLTSGEIVYLLEKIDT-DWYRGNCRNQIGIFPANYVKVIIDIPEGG 559

Query: 61  RGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
            G  E     C +              C   F Y  EQ DEL    GEI+ + + + + W
Sbjct: 560 NGKRECVSSHCVKGSR-----------CVARFEYIGEQKDELSFSEGEIIILKEYVNEEW 608

Query: 121 WLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
             G+  G+ G FP NFVE ++  P S  N     V    ++    S+   +S P      
Sbjct: 609 ARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP------ 662

Query: 181 SHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPP 240
              E    L  +  E  D+L+ +RGD +++L +   D  W  G  Q R G+FP  FV P 
Sbjct: 663 --AEWCEALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRLQDREGIFPAVFVRPC 718

Query: 241 P 241
           P
Sbjct: 719 P 719



 Score = 88.2 bits (217), Expect = 3e-17
 Identities = 54/235 (22%), Positives = 101/235 (42%), Gaps = 38/235 (16%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           Y  +++DELS + G+++    +V    W RGE  GR G+FP   V+ + +          
Sbjct: 582 YIGEQKDELSFSEGEIIILKEYVNEE-WARGEVRGRTGIFPLNFVEPVEDYPTSGANVLS 640

Query: 69  PRCARRR------GHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWL 122
            +   +        +   +  P  WC+   S++ E +D+L  + G+ +++++ ++  W  
Sbjct: 641 TKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCR 700

Query: 123 GKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSH 182
           G+   + G FP+ FV                   P P     +           L  V  
Sbjct: 701 GRLQDREGIFPAVFVR------------------PCPAEAKSM-----------LAIVPK 731

Query: 183 PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
               + L+D++ E  DEL+ + GD++  L    +D  W  GE  G+ G+FP N++
Sbjct: 732 GRKAKALYDFRGENEDELSFKAGDIITELESVDDD--WMSGELMGKSGIFPKNYI 784



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 37/135 (27%), Positives = 63/135 (46%), Gaps = 16/135 (11%)

Query: 6   LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGE 65
           L  + A+  D+LS   GD ++ +  + +  W RG    R G+FP   V+  P       E
Sbjct: 669 LHSFTAETSDDLSFKRGDRIQILERLDS-DWCRGRLQDREGIFPAVFVRPCP------AE 721

Query: 66  ARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKK 125
           A+       +G  AK           + +  E  DEL  +AG+I+  ++ ++D W  G+ 
Sbjct: 722 AKSMLAIVPKGRKAK---------ALYDFRGENEDELSFKAGDIITELESVDDDWMSGEL 772

Query: 126 NGQLGAFPSNFVELL 140
            G+ G FP N+++ L
Sbjct: 773 MGKSGIFPKNYIQFL 787



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 56/233 (24%), Positives = 93/233 (39%), Gaps = 38/233 (16%)

Query: 238 LPPPPIKKLVPRKVVSRE-----SAPIKE---PKKLMPKTSLPTVKKLATAT-TGPSKAK 288
           +P P  + L+ +K VS E     SAP+K    P +L   +     K L       P    
Sbjct: 135 VPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPV 194

Query: 289 TSRTPSRDSQKLTSRDS---GPNGGF--QSGGS---YHPGRKRSKTQTPQQRSVSSQEEE 340
               P  D   ++  D     P+G    +S GS     P +  +KT+  ++R+V      
Sbjct: 195 LQSKPLVDIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQP---- 250

Query: 341 HSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKI-----PAPDKVPSPEKTLTLGDK 395
             +P + P+V R P        E P +P   P+ K I         K+ + E+T  L  +
Sbjct: 251 --APTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNL--E 306

Query: 396 ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPE 448
           ++ PG  T G +  P ++P       P +  +IP     P   +  ++P  P+
Sbjct: 307 SNHPG-QTGGFVRVPPRLPP-----RPVNGKTIPTQQ--PPTKVPPERPPPPK 351



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 71/362 (19%), Positives = 108/362 (29%), Gaps = 68/362 (18%)

Query: 269 TSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQT 328
           + LP   ++   +  P    +S  PS   +   +R SG    + SG          +  T
Sbjct: 29  SGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAANRASGE---WDSGTENRLKVTSKEGLT 85

Query: 329 PQQRSVSSQEEEHSSPVKAPSVKRTPMPD--KTATPERP---PAPENAPSSKKIPAPDKV 383
           P        +E  S PV  P + + P P   ++  PE P   P  E++ S KK+P P   
Sbjct: 86  PYP----PLQEAGSIPVTKPELPKKPNPGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPR 141

Query: 384 PSPEKTLTLGDKASIP-------------------------GNSTSGKIPAP-------- 410
           P   K     +  + P                         G       P P        
Sbjct: 142 PLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLV 201

Query: 411 ---------DKVPTPEKMVTPE--------DKASIPENSIIPEETLTVDKPSTPERVFSV 453
                    D +PTP   +  E        D   +P  +   +E      P+    V  +
Sbjct: 202 DIDLISFDDDVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPTRKPTVIRI 261

Query: 454 EESP--ALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEA 511
              P   L   P    P P   P+G+   T+   L+       + +    Q   F     
Sbjct: 262 PAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNHPGQTGGFVRVPP 321

Query: 512 LQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRG----DSSPRQAELK 567
               +    K  P+ Q     P   PP P  S       K    R     D   +Q+ L 
Sbjct: 322 RLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLA 381

Query: 568 SG 569
           +G
Sbjct: 382 TG 383


>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
          Length = 1220

 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 42/241 (17%)

Query: 2    EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLR 61
            E + +  Y + ++ +L+   GDV+   +      W  G  G + G+FP   V+   +   
Sbjct: 1006 EFIAMYTYESSEQGDLTFQQGDVILVTK--KDGDWWTGTVGDKAGVFPSNYVRL--KDSE 1061

Query: 62   GSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWW 121
            GSG A +       G   K P      +V  SY+    ++L L  G+++ + K+   GWW
Sbjct: 1062 GSGTAGKT------GSLGKKPEI---AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWW 1112

Query: 122  LGK-----KNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDY 176
             G+     K  Q+G FP+N+V+LL  G   +           P  PPK ++LA       
Sbjct: 1113 EGELQARGKKRQIGWFPANYVKLLSPGTSKIT----------PTEPPKSTALAA-----V 1157

Query: 177  LQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNF 236
             Q +        ++DY  +  DELA  +G ++ VL+K  ED  WW+GE  G+ G+FP N+
Sbjct: 1158 CQVIG-------MYDYTAQNDDELAFNKGQIINVLNK--EDPDWWKGEVNGQVGLFPSNY 1208

Query: 237  V 237
            V
Sbjct: 1209 V 1209



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 46/149 (30%), Positives = 70/149 (46%), Gaps = 18/149 (12%)

Query: 5    VLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGR-----YGLFPERLVQEIPET 59
            V+A Y A   ++L+LAPG ++  +R     GW  GE   R      G FP   V+     
Sbjct: 1081 VIASYTATGPEQLTLAPGQLIL-IRKKNPGGWWEGELQARGKKRQIGWFPANYVK----- 1134

Query: 60   LRGSGEARRPRCARRRGHPAKHPRPQRWCKV--NFSYSPEQADELKLQAGEIVEMIKEIE 117
            L   G ++          P K       C+V   + Y+ +  DEL    G+I+ ++ + +
Sbjct: 1135 LLSPGTSKITPT-----EPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKED 1189

Query: 118  DGWWLGKKNGQLGAFPSNFVELLDSGPPS 146
              WW G+ NGQ+G FPSN+V+L     PS
Sbjct: 1190 PDWWKGEVNGQVGLFPSNYVKLTTDMDPS 1218



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 41/146 (28%), Positives = 73/146 (50%), Gaps = 12/146 (8%)

Query: 92   FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPD 151
            + +  ++ + L     +++ ++++ +D WW G+  GQ G FP ++V+L+ SGP       
Sbjct: 922  YPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI-SGPIRKST-- 977

Query: 152  MPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVL 211
              S+  G    P  +SL   + P     VS  E +  ++ Y+     +L  ++GDV+ V 
Sbjct: 978  --SMDSGSSESP--ASLKRVASPAAKPVVSGEE-FIAMYTYESSEQGDLTFQQGDVILV- 1031

Query: 212  SKTTEDKGWWEGECQGRRGVFPDNFV 237
              T +D  WW G    + GVFP N+V
Sbjct: 1032 --TKKDGDWWTGTVGDKAGVFPSNYV 1055



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 6/105 (5%)

Query: 186 YRVLFDYQPEAPDELALRRGDVVKVLSK-----TTEDKGWWEGECQGRRGVFPDNFVLPP 240
           YR L+ ++  + DE+ ++ GD+V V  +      T + GW  GE +G+ G FP N+    
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804

Query: 241 PPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPS 285
           P  +   P K V+ +S     PK  + +T  P     +  +T P+
Sbjct: 805 PENEVPAPVKPVT-DSTSAPAPKLALRETPAPLAVTSSEPSTTPN 848



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 9/78 (11%)

Query: 92  FSYSPEQADELKLQAGEIV----EMIKEI---EDGWWLGKKNGQLGAFPSNFVELL-DSG 143
           + +     DE+ +Q G+IV    E + E    E GW  G+  G+ G FP+N+ E + ++ 
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENE 808

Query: 144 PPSLGNPDMPSVS-PGPQ 160
            P+   P   S S P P+
Sbjct: 809 VPAPVKPVTDSTSAPAPK 826



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 32/125 (25%), Positives = 51/125 (40%), Gaps = 28/125 (22%)

Query: 632 EELPPKEEVAPKEEVPPIERAFAQKT------------RPIKPPPDSQETLALPSLVPQN 679
           + LPP   V P E +PP  R     +            R  + P    E   L   +P  
Sbjct: 293 QPLPP---VLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVT 349

Query: 680 YTENKNEGVDVTSLRGEVESLRRALELME---------VQLERKLTDIWEELKSEKEQRR 730
           + + K E  +    RG +E  +R   L+E          QLER   +  E  + E+E++R
Sbjct: 350 FEDKKRENFE----RGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKR 405

Query: 731 RLEVQ 735
           +LE++
Sbjct: 406 QLELE 410


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 42/241 (17%)

Query: 2    EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLR 61
            E + +  Y + ++ +L+   GDV+   +      W  G  G + G+FP   V+   +   
Sbjct: 1006 EFIAMYTYESSEQGDLTFQQGDVILVTK--KDGDWWTGTVGDKAGVFPSNYVRL--KDSE 1061

Query: 62   GSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWW 121
            GSG A +       G   K P      +V  SY+    ++L L  G+++ + K+   GWW
Sbjct: 1062 GSGTAGKT------GSLGKKPEI---AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWW 1112

Query: 122  LGK-----KNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDY 176
             G+     K  Q+G FP+N+V+LL  G   +           P  PPK ++LA       
Sbjct: 1113 EGELQARGKKRQIGWFPANYVKLLSPGTSKIT----------PTEPPKSTALAA-----V 1157

Query: 177  LQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNF 236
             Q +        ++DY  +  DELA  +G ++ VL+K  ED  WW+GE  G+ G+FP N+
Sbjct: 1158 CQVIG-------MYDYTAQNDDELAFNKGQIINVLNK--EDPDWWKGEVNGQVGLFPSNY 1208

Query: 237  V 237
            V
Sbjct: 1209 V 1209



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 46/149 (30%), Positives = 70/149 (46%), Gaps = 18/149 (12%)

Query: 5    VLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGR-----YGLFPERLVQEIPET 59
            V+A Y A   ++L+LAPG ++  +R     GW  GE   R      G FP   V+     
Sbjct: 1081 VIASYTATGPEQLTLAPGQLIL-IRKKNPGGWWEGELQARGKKRQIGWFPANYVK----- 1134

Query: 60   LRGSGEARRPRCARRRGHPAKHPRPQRWCKV--NFSYSPEQADELKLQAGEIVEMIKEIE 117
            L   G ++          P K       C+V   + Y+ +  DEL    G+I+ ++ + +
Sbjct: 1135 LLSPGTSKITPT-----EPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKED 1189

Query: 118  DGWWLGKKNGQLGAFPSNFVELLDSGPPS 146
              WW G+ NGQ+G FPSN+V+L     PS
Sbjct: 1190 PDWWKGEVNGQVGLFPSNYVKLTTDMDPS 1218



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 41/146 (28%), Positives = 73/146 (50%), Gaps = 12/146 (8%)

Query: 92   FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPD 151
            + +  ++ + L     +++ ++++ +D WW G+  GQ G FP ++V+L+ SGP       
Sbjct: 922  YPWRAKKDNHLNFNKNDVITVLEQ-QDMWWFGEVQGQKGWFPKSYVKLI-SGPIRKST-- 977

Query: 152  MPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVL 211
              S+  G    P  +SL   + P     VS  E +  ++ Y+     +L  ++GDV+ V 
Sbjct: 978  --SMDSGSSESP--ASLKRVASPAAKPVVSGEE-FIAMYTYESSEQGDLTFQQGDVILV- 1031

Query: 212  SKTTEDKGWWEGECQGRRGVFPDNFV 237
              T +D  WW G    + GVFP N+V
Sbjct: 1032 --TKKDGDWWTGTVGDKAGVFPSNYV 1055



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 6/105 (5%)

Query: 186 YRVLFDYQPEAPDELALRRGDVVKVLSK-----TTEDKGWWEGECQGRRGVFPDNFVLPP 240
           YR L+ ++  + DE+ ++ GD+V V  +      T + GW  GE +G+ G FP N+    
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKI 804

Query: 241 PPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPS 285
           P  +   P K V+ +S     PK  + +T  P     +  +T P+
Sbjct: 805 PENEVPAPVKPVT-DSTSAPAPKLALRETPAPLAVTSSEPSTTPN 848



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 9/78 (11%)

Query: 92  FSYSPEQADELKLQAGEIV----EMIKEI---EDGWWLGKKNGQLGAFPSNFVELL-DSG 143
           + +     DE+ +Q G+IV    E + E    E GW  G+  G+ G FP+N+ E + ++ 
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENE 808

Query: 144 PPSLGNPDMPSVS-PGPQ 160
            P+   P   S S P P+
Sbjct: 809 VPAPVKPVTDSTSAPAPK 826



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 32/125 (25%), Positives = 51/125 (40%), Gaps = 28/125 (22%)

Query: 632 EELPPKEEVAPKEEVPPIERAFAQKT------------RPIKPPPDSQETLALPSLVPQN 679
           + LPP   V P E +PP  R     +            R  + P    E   L   +P  
Sbjct: 293 QPLPP---VLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVT 349

Query: 680 YTENKNEGVDVTSLRGEVESLRRALELME---------VQLERKLTDIWEELKSEKEQRR 730
           + + K E  +    RG +E  +R   L+E          QLER   +  E  + E+E++R
Sbjct: 350 FEDKKRENFE----RGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKR 405

Query: 731 RLEVQ 735
           +LE++
Sbjct: 406 QLELE 410


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 185/801 (23%), Positives = 312/801 (38%), Gaps = 116/801 (14%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEF-GGRYGLFPERLVQEIPETLRGSGEAR 67
           + +Q+ D L L  GD+V  +  +P  GWL+G    G  G FP   V+E    L  S ++R
Sbjct: 77  FTSQELDNLPLHRGDLVI-LDGIPTAGWLQGRSCWGARGFFPSSCVRE----LCLSSQSR 131

Query: 68  RPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG 127
           +           ++   Q   +     S +  +EL  + G+++ +I   E GW+ G+  G
Sbjct: 132 QWHSQSALFQIPEYSMGQ--ARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG 189

Query: 128 QLGAFPSNFVELLDSGP-------PSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           + G FP  FVELL  GP        S GN D   V+     P     +  D   +     
Sbjct: 190 RRGIFPEGFVELL--GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEE----- 242

Query: 181 SHPEVYRV-LFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLP 239
             P  Y V L+ +Q   P+EL    GD +++L+ T ED GW EG  +GR G+FP  FV  
Sbjct: 243 -EPGTYGVALYRFQALEPNELDFEVGDKIRILA-TLED-GWLEGSLKGRTGIFPYRFV-- 297

Query: 240 PPPIKKLVP-RKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ 298
                KL P  +V    + P +     +P+TSL  ++   T      + +TS   + +  
Sbjct: 298 -----KLCPDTRVEETMALPQEGSLARIPETSLDCLEN--TLGVEEQRHETSDHEAEEPD 350

Query: 299 KLTSR-DSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPD 357
            + S   + P G   S   Y   R   + +        S   E   P+   S    P   
Sbjct: 351 CIISEAPTSPLGHLTS--EYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEV 408

Query: 358 KTATPERPPAP---------------ENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNS 402
                 +P  P                + P S++   PD +P   +T    D AS+P   
Sbjct: 409 VNGISSQPQVPFHPNLQKSQYYSTVGGSHPHSEQY--PDLLPLEART---RDYASLPPKR 463

Query: 403 TSGKIPAPDKVPTP---------EKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSV 453
              ++    K   P          ++V P  + S P+   +   T    K      V+S+
Sbjct: 464 MYSQLKTLQKPVLPLYRGSSVSASRVVKP--RQSSPQLHNLASYT----KKHHTSSVYSI 517

Query: 454 EESPALEAPPMDK--VPNPKMAPLGDEAPTLEKVLTPELSEEEVS-----TRDDIQFHHF 506
            E   ++  P  +  V        GD +  L+  LT +L E E S     T  D    HF
Sbjct: 518 SERLEMKPGPQAQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHF 577

Query: 507 ------SSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSS-------ERCLGEMKCT 553
                 S ++ ++     + +++   + +A  P  P P  P S       ++ L      
Sbjct: 578 SIMDFNSEKDIVRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPL 637

Query: 554 LVRGDSS---PRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQR 610
           +VR       P  A+ ++   S   L +  P  E  TL +E P +  R+ ++ +P     
Sbjct: 638 VVRPSRPAPLPPSAQQRTNAVSPKLLSRHRPTCE--TLEKEGPGHMGRSLDQTSPCPLVL 695

Query: 611 PLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETL 670
              EE+     + S+ +  L   L  K++          E + A+    +K    + E+L
Sbjct: 696 VRIEEMERDLDMYSRAQEELNLMLEEKQD----------ESSRAETLEDLKFCESNIESL 745

Query: 671 ALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEKEQRR 730
            +     +  T   ++   + +  G V     A    +  LE++   I E L++E++  R
Sbjct: 746 NMELQQLREMTLLSSQSSSLVAPSGSVS----AENPEQRMLEKRAKVIEELLQTERDYIR 801

Query: 731 RLEV---QVMQGTQKSQTPRV 748
            LE+   ++M   Q++Q P +
Sbjct: 802 DLEMCIERIMVPMQQAQVPNI 822



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 43/148 (29%), Positives = 66/148 (44%), Gaps = 15/148 (10%)

Query: 6   LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ------EIPET 59
           L G  AQ ++EL    GDV+  +  VP  GW  GE  GR G+FPE  V+       + E+
Sbjct: 153 LMGLSAQLDEELDFREGDVI-TIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDES 211

Query: 60  LRG--------SGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVE 111
           +          +GE   P      G       P  +    + +   + +EL  + G+ + 
Sbjct: 212 VSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIR 271

Query: 112 MIKEIEDGWWLGKKNGQLGAFPSNFVEL 139
           ++  +EDGW  G   G+ G FP  FV+L
Sbjct: 272 ILATLEDGWLEGSLKGRTGIFPYRFVKL 299



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 41/147 (27%), Positives = 67/147 (45%), Gaps = 37/147 (25%)

Query: 92  FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPD 151
           F + P  ++EL L  G+I+E++  +++ W LGKK    G FPS+FVE++           
Sbjct: 11  FDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIV----------T 60

Query: 152 MPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVL 211
           +PS+  G +                        ++  + ++  +  D L L RGD+V + 
Sbjct: 61  IPSLKEGER------------------------LFVCICEFTSQELDNLPLHRGDLVILD 96

Query: 212 SKTTEDKGWWEG-ECQGRRGVFPDNFV 237
              T   GW +G  C G RG FP + V
Sbjct: 97  GIPT--AGWLQGRSCWGARGFFPSSCV 121



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 2/53 (3%)

Query: 185 VYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
           V R +FD+ P   +EL L  GD+++VL+    D+ W  G+ +   G FP +FV
Sbjct: 6   VVRAIFDFCPSVSEELPLFVGDIIEVLA--VVDEFWLLGKKEDVTGQFPSSFV 56



 Score = 37.4 bits (85), Expect = 0.052
 Identities = 15/56 (26%), Positives = 30/56 (53%), Gaps = 2/56 (3%)

Query: 184  EVYRVLFDYQPEAPDELALRRGDVVKVLS--KTTEDKGWWEGECQGRRGVFPDNFV 237
            +VY  ++ ++   P+EL++     +K+L     T +  WW  E  G++G  P N++
Sbjct: 1516 QVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYI 1571



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 14/51 (27%), Positives = 29/51 (56%), Gaps = 6/51 (11%)

Query: 92   FSYSPEQADELKLQAGEIVEMIKEIED-----GWWLGKKNGQLGAFPSNFV 137
            +++     +EL + A + ++++ E +D      WWL + NG+ G  PSN++
Sbjct: 1522 YTFKARNPNELSVSANQKLKIL-EFKDVTGNTEWWLAEVNGKKGYVPSNYI 1571


>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
           sapiens]
          Length = 740

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   EL L  GD+V   + +  + W  GE  GR G+FP   ++ +P   +   +   
Sbjct: 510 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 568

Query: 69  PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
           P      G               F+++ +   E+  + GE + +++++++ W+ G+  G 
Sbjct: 569 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 618

Query: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
            + G FP  +V+++    P + NP    D+P       S +  PQ+P           PD
Sbjct: 619 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 673

Query: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
             QT      Y+ L+ Y P+  DEL LR GD+V V+ K   D GW+ G  +  +  G FP
Sbjct: 674 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 731

Query: 234 DNFVLP 239
            N+V P
Sbjct: 732 GNYVKP 737



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 52/210 (24%), Positives = 98/210 (46%), Gaps = 36/210 (17%)

Query: 86  RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
           R  +  F +  +   EL LQ G+IV + K+I+  W+ G+ +G++G FP  ++ELL   PP
Sbjct: 502 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 558

Query: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
           +              +P KL+          +Q + + E     F++  +   E++ R+G
Sbjct: 559 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 597

Query: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPRKVVSRESAPIKE 261
           + + +L +   D+ W+EG   G  R+G+FP  +  V+  P +K  V    +   S+P + 
Sbjct: 598 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 655

Query: 262 PKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
                  T+ P   +       P +++TS+
Sbjct: 656 ------ATASPQQPQAQQRRVTPDRSQTSQ 679



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    +    + E+S   G+ +  +R V    W  G   G  R G+FP   V  I   
Sbjct: 577 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 635

Query: 60  L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
           L                    +   ++P+  +RR  P +    Q        +SY P+  
Sbjct: 636 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 695

Query: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           DEL+L+ G+IV+++++ +DGW++G  ++  Q G FP N+V+ L
Sbjct: 696 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738


>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
           sapiens]
          Length = 781

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   EL L  GD+V   + +  + W  GE  GR G+FP   ++ +P   +   +   
Sbjct: 551 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 609

Query: 69  PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
           P      G               F+++ +   E+  + GE + +++++++ W+ G+  G 
Sbjct: 610 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659

Query: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
            + G FP  +V+++    P + NP    D+P       S +  PQ+P           PD
Sbjct: 660 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 714

Query: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
             QT      Y+ L+ Y P+  DEL LR GD+V V+ K   D GW+ G  +  +  G FP
Sbjct: 715 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 772

Query: 234 DNFVLP 239
            N+V P
Sbjct: 773 GNYVKP 778



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 52/210 (24%), Positives = 98/210 (46%), Gaps = 36/210 (17%)

Query: 86  RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
           R  +  F +  +   EL LQ G+IV + K+I+  W+ G+ +G++G FP  ++ELL   PP
Sbjct: 543 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 599

Query: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
           +              +P KL+          +Q + + E     F++  +   E++ R+G
Sbjct: 600 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 638

Query: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPRKVVSRESAPIKE 261
           + + +L +   D+ W+EG   G  R+G+FP  +  V+  P +K  V    +   S+P + 
Sbjct: 639 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 696

Query: 262 PKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
                  T+ P   +       P +++TS+
Sbjct: 697 ------ATASPQQPQAQQRRVTPDRSQTSQ 720



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    +    + E+S   G+ +  +R V    W  G   G  R G+FP   V  I   
Sbjct: 618 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 676

Query: 60  L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
           L                    +   ++P+  +RR  P +    Q        +SY P+  
Sbjct: 677 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 736

Query: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           DEL+L+ G+IV+++++ +DGW++G  ++  Q G FP N+V+ L
Sbjct: 737 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779


>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 816

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   EL L  GD+V   + +  + W  GE  GR G+FP   ++ +P   +   +   
Sbjct: 586 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 644

Query: 69  PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
           P      G               F+++ +   E+  + GE + +++++++ W+ G+  G 
Sbjct: 645 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 694

Query: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
            + G FP  +V+++    P + NP    D+P       S +  PQ+P           PD
Sbjct: 695 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 749

Query: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
             QT      Y+ L+ Y P+  DEL LR GD+V V+ K   D GW+ G  +  +  G FP
Sbjct: 750 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 807

Query: 234 DNFVLP 239
            N+V P
Sbjct: 808 GNYVKP 813



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 58/222 (26%), Positives = 103/222 (46%), Gaps = 39/222 (17%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RR H  K  RP R     F +  +   EL LQ G+IV + K+I+  W+ G+ +G++G FP
Sbjct: 569 RRRHDDKEMRPAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP 625

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
             ++ELL   PP+              +P KL+          +Q + + E     F++ 
Sbjct: 626 RTYIELL---PPA-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFN 661

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPR 249
            +   E++ R+G+ + +L +   D+ W+EG   G  R+G+FP  +  V+  P +K  V  
Sbjct: 662 GDTQVEMSFRKGERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDY 719

Query: 250 KVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
             +   S+P +        T+ P   +       P +++TS+
Sbjct: 720 MDLPFSSSPSRS------ATASPQQPQAQQRRVTPDRSQTSQ 755



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    +    + E+S   G+ +  +R V    W  G   G  R G+FP   V  I   
Sbjct: 653 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 711

Query: 60  L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
           L                    +   ++P+  +RR  P +    Q        +SY P+  
Sbjct: 712 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 771

Query: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           DEL+L+ G+IV+++++ +DGW++G  ++  Q G FP N+V+ L
Sbjct: 772 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814


>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 684

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   EL L  GD+V   + +  + W  GE  GR G+FP   ++ +P   +   +   
Sbjct: 454 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 512

Query: 69  PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
           P      G               F+++ +   E+  + GE + +++++++ W+ G+  G 
Sbjct: 513 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 562

Query: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
            + G FP  +V+++    P + NP    D+P       S +  PQ+P           PD
Sbjct: 563 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 617

Query: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
             QT      Y+ L+ Y P+  DEL LR GD+V V+ K   D GW+ G  +  +  G FP
Sbjct: 618 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 675

Query: 234 DNFVLP 239
            N+V P
Sbjct: 676 GNYVKP 681



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 58/222 (26%), Positives = 103/222 (46%), Gaps = 39/222 (17%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RR H  K  RP R     F +  +   EL LQ G+IV + K+I+  W+ G+ +G++G FP
Sbjct: 437 RRRHDDKEMRPAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP 493

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
             ++ELL   PP+              +P KL+          +Q + + E     F++ 
Sbjct: 494 RTYIELL---PPA-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFN 529

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPR 249
            +   E++ R+G+ + +L +   D+ W+EG   G  R+G+FP  +  V+  P +K  V  
Sbjct: 530 GDTQVEMSFRKGERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDY 587

Query: 250 KVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
             +   S+P +        T+ P   +       P +++TS+
Sbjct: 588 MDLPFSSSPSRS------ATASPQQPQAQQRRVTPDRSQTSQ 623



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    +    + E+S   G+ +  +R V    W  G   G  R G+FP   V  I   
Sbjct: 521 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 579

Query: 60  L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
           L                    +   ++P+  +RR  P +    Q        +SY P+  
Sbjct: 580 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 639

Query: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           DEL+L+ G+IV+++++ +DGW++G  ++  Q G FP N+V+ L
Sbjct: 640 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682


>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
           sapiens]
          Length = 492

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 266 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 315

Query: 69  PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                 +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 316 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 370

Query: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 371 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 428

Query: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
            +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 429 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 486

Query: 235 NFV 237
           N+V
Sbjct: 487 NYV 489



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 249 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 305

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 306 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 342

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 343 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 386



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 334 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 392

Query: 60  LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
            +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 393 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 452

Query: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 453 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)

Query: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
           +P  PS +   + P   SS   D    +P +   T    ++  + ++D++ +   EL+ +
Sbjct: 218 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 277

Query: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
           +GD V +L K   D+ W+EGE  GR G+FP ++V    P +K  P +
Sbjct: 278 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 322


>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
            sapiens]
          Length = 1004

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9    YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
            ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 778  FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 827

Query: 69   PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                  +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 828  -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 882

Query: 124  KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
            K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 883  KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 940

Query: 181  SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
             +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 941  ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 998

Query: 235  NFV 237
            N+V
Sbjct: 999  NYV 1001



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 761 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 817

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 818 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 854

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 855 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 898



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2    EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
            E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 846  EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 904

Query: 60   LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
             +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 905  TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 964

Query: 103  KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
            +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 965  ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 22/64 (34%), Positives = 39/64 (60%), Gaps = 2/64 (3%)

Query: 187 RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKL 246
           + ++D++ +   EL+ ++GD V +L K   D+ W+EGE  GR G+FP ++V    P +K 
Sbjct: 773 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 830

Query: 247 VPRK 250
            P +
Sbjct: 831 QPAR 834


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
           sapiens]
          Length = 824

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 598 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 647

Query: 69  PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                 +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 648 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 702

Query: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 703 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 760

Query: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
            +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 761 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 818

Query: 235 NFV 237
           N+V
Sbjct: 819 NYV 821



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 581 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 637

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 638 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 674

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 675 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 718



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 666 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 724

Query: 60  LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
            +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 725 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 784

Query: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 785 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)

Query: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
           +P  PS +   + P   SS   D    +P +   T    ++  + ++D++ +   EL+ +
Sbjct: 550 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 609

Query: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
           +GD V +L K   D+ W+EGE  GR G+FP ++V    P +K  P +
Sbjct: 610 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 654


>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
           sapiens]
          Length = 661

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 435 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 484

Query: 69  PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                 +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 485 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 539

Query: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 540 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 597

Query: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
            +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 598 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 655

Query: 235 NFV 237
           N+V
Sbjct: 656 NYV 658



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 418 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 474

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 475 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 511

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 512 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 555



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 503 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 561

Query: 60  LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
            +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 562 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 621

Query: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 622 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)

Query: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
           +P  PS +   + P   SS   D    +P +   T    ++  + ++D++ +   EL+ +
Sbjct: 387 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 446

Query: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
           +GD V +L K   D+ W+EGE  GR G+FP ++V    P +K  P +
Sbjct: 447 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 491


>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 731

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 505 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 554

Query: 69  PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                 +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 555 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 609

Query: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 610 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 667

Query: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
            +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 668 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 725

Query: 235 NFV 237
           N+V
Sbjct: 726 NYV 728



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 488 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 544

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 545 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 581

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 582 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 625



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 573 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 631

Query: 60  LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
            +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 632 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 691

Query: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 692 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)

Query: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
           +P  PS +   + P   SS   D    +P +   T    ++  + ++D++ +   EL+ +
Sbjct: 457 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 516

Query: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
           +GD V +L K   D+ W+EGE  GR G+FP ++V    P +K  P +
Sbjct: 517 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 561


>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
           sapiens]
          Length = 644

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 418 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 467

Query: 69  PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                 +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 468 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 522

Query: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 523 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 580

Query: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
            +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 581 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 638

Query: 235 NFV 237
           N+V
Sbjct: 639 NYV 641



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 401 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 457

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 458 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 494

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 495 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 538



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 486 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 544

Query: 60  LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
            +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 545 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 604

Query: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 605 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)

Query: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
           +P  PS +   + P   SS   D    +P +   T    ++  + ++D++ +   EL+ +
Sbjct: 370 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 429

Query: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
           +GD V +L K   D+ W+EGE  GR G+FP ++V    P +K  P +
Sbjct: 430 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 474


>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
            sapiens]
          Length = 1100

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9    YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
            ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 874  FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 923

Query: 69   PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                  +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 924  -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 978

Query: 124  KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
            K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 979  KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 1036

Query: 181  SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
             +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 1037 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 1094

Query: 235  NFV 237
            N+V
Sbjct: 1095 NYV 1097



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 857 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 913

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 914 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 950

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 951 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 994



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2    EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
            E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 942  EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 1000

Query: 60   LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
             +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 1001 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 1060

Query: 103  KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
            +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 1061 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 22/64 (34%), Positives = 39/64 (60%), Gaps = 2/64 (3%)

Query: 187 RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKL 246
           + ++D++ +   EL+ ++GD V +L K   D+ W+EGE  GR G+FP ++V    P +K 
Sbjct: 869 KAVYDFKAQTSKELSFKKGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKA 926

Query: 247 VPRK 250
            P +
Sbjct: 927 QPAR 930


>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
           sapiens]
          Length = 666

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 67/243 (27%), Positives = 115/243 (47%), Gaps = 33/243 (13%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   ELS   GD V  +R +  + W  GE  GR G+FP   V+++            
Sbjct: 440 FKAQTSKELSFKKGDTVYILRKID-QNWYEGEHHGRVGIFPISYVEKLTPP--------- 489

Query: 69  PRCARRRGHPAKHPRPQRWCKVN-----FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG 123
                 +  PA+ P P +  ++      ++++ +   EL L+ G+ V ++K ++  W+ G
Sbjct: 490 -----EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEG 544

Query: 124 KKNG--QLGAFPSNFVELLDSGPPSLGN-PDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
           K  G  + G FP ++VE++        + PD P   P      ++ SL+ + P   + T 
Sbjct: 545 KIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPI--PHSYSSDRIHSLSSNKPQRPVFTH 602

Query: 181 SH----PEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFPD 234
            +     E ++ L++Y P   DEL LR  DV+ V+ K   D GW+ G  +  +  G FP 
Sbjct: 603 ENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKC--DDGWFVGTSRRTKFFGTFPG 660

Query: 235 NFV 237
           N+V
Sbjct: 661 NYV 663



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 30/166 (18%)

Query: 74  RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
           RRG P K   P    K  + +  + + EL  + G+ V ++++I+  W+ G+ +G++G FP
Sbjct: 423 RRGTPEKEKLP---AKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 479

Query: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
            ++VE L   PP    P  P   P P +P ++                        +++ 
Sbjct: 480 ISYVEKLT--PPEKAQPARP---PPPAQPGEIGEAI------------------AKYNFN 516

Query: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFV 237
            +   EL+LR+GD V +L +   D+ W+EG+  G  R+G+FP ++V
Sbjct: 517 ADTNVELSLRKGDRVILLKRV--DQNWYEGKIPGTNRQGIFPVSYV 560



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 41/160 (25%), Positives = 76/160 (47%), Gaps = 22/160 (13%)

Query: 2   EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
           E +    + A    ELSL  GD V  ++ V  + W  G+  G  R G+FP   V+ + + 
Sbjct: 508 EAIAKYNFNADTNVELSLRKGDRVILLKRVD-QNWYEGKIPGTNRQGIFPVSYVEVVKKN 566

Query: 60  LRGSGEARRPRCARR----RGHPAKHPRPQRWCKVN-------------FSYSPEQADEL 102
            +G+ +   P         R H     +PQR    +             ++Y+P   DEL
Sbjct: 567 TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDEL 626

Query: 103 KLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
           +L+  ++++++++ +DGW++G  ++    G FP N+V+ L
Sbjct: 627 ELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 31/107 (28%), Positives = 55/107 (51%), Gaps = 7/107 (6%)

Query: 149 NPDMPSVSPGPQRPPKLSSLAYD----SPPDYLQTVSHPEV-YRVLFDYQPEAPDELALR 203
           +P  PS +   + P   SS   D    +P +   T    ++  + ++D++ +   EL+ +
Sbjct: 392 SPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFK 451

Query: 204 RGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLVPRK 250
           +GD V +L K   D+ W+EGE  GR G+FP ++V    P +K  P +
Sbjct: 452 KGDTVYILRKI--DQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPAR 496


>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
           sapiens]
          Length = 905

 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 71/264 (26%), Positives = 117/264 (44%), Gaps = 49/264 (18%)

Query: 9   YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
           ++AQ   EL L  GD+V   + +  + W  GE  GR G+FP   ++ +P   +   +   
Sbjct: 655 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 713

Query: 69  PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
           P      G               F+++ +   E+  + GE + +++++++ W+ G+  G 
Sbjct: 714 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 763

Query: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMPSVSPGPQRP----PKLS------------ 166
            + G FP  +V+++    P + NP    D+P  S  P R     P+LS            
Sbjct: 764 SRQGIFPITYVDVIKR--PLVKNPVDYMDLP-FSSSPSRSATASPQLSHHSLRAGPDLTE 820

Query: 167 -SLAYDSP--------PDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTED 217
              +Y  P        PD  QT      Y+ L+ Y P+  DEL LR GD+V V+ K   D
Sbjct: 821 SEKSYVQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--D 878

Query: 218 KGWWEGECQGRR--GVFPDNFVLP 239
            GW+ G  +  +  G FP N+V P
Sbjct: 879 DGWFVGTSRRTKQFGTFPGNYVKP 902



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 47/177 (26%), Positives = 86/177 (48%), Gaps = 30/177 (16%)

Query: 86  RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
           R  +  F +  +   EL LQ G+IV + K+I+  W+ G+ +G++G FP  ++ELL   PP
Sbjct: 647 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 703

Query: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
           +              +P KL+          +Q + + E     F++  +   E++ R+G
Sbjct: 704 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 742

Query: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPRKVVSRESAP 258
           + + +L +   D+ W+EG   G  R+G+FP  +  V+  P +K  V    +   S+P
Sbjct: 743 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 797



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 26/77 (33%), Positives = 47/77 (61%), Gaps = 4/77 (5%)

Query: 68  RPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQADELKLQAGEIVEMIKEIEDGWWLG-- 123
           +P+  +RR  P +    Q        +SY P+  DEL+L+ G+IV+++++ +DGW++G  
Sbjct: 827 QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS 886

Query: 124 KKNGQLGAFPSNFVELL 140
           ++  Q G FP N+V+ L
Sbjct: 887 RRTKQFGTFPGNYVKPL 903



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 104/531 (19%), Positives = 197/531 (37%), Gaps = 88/531 (16%)

Query: 245 KLVPRKVVSRESAPI----KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKL 300
           K++P K V   S  +     +P K+       T++  ++    PS +  S   +R  +  
Sbjct: 40  KIIPVKTVKNASGLVLPTDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESK 99

Query: 301 TSRDSGPNGGFQ--------SGGSYHPGRKRSKTQTPQQRSVSSQEEE----HSSPVKAP 348
              +  P+   +        + G+  P    +K       ++ S + +    HS P +A 
Sbjct: 100 PGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARAS 159

Query: 349 S----VKRTPMPDKTATPERPPAPENAPSSKKIPAPD---KVPSPEKTLTLGDKASIPGN 401
                + +TP       P  PPAPE+    +++  PD    V S + +  L + +S    
Sbjct: 160 GSFAPISQTPPSFSPPPPLVPPAPEDL---RRVSEPDLTGAVSSTDSSPLLNEVSSSLIG 216

Query: 402 STSGKIPAPDKVPT--PEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPAL 459
           + S   P+  K  +  P   +       +  N    +   ++  P +  RV   + +P  
Sbjct: 217 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 276

Query: 460 EAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYF- 518
           E P        K A   D++  + K  T +LS+  +   D++     ++E +    K   
Sbjct: 277 EKPTSPGKAIEKRAK--DDSRRVVK-STQDLSDVSM---DEVGIPLRNTERSKDWYKTMF 330

Query: 519 --VAKEDPSSQEEAHTP----EAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPAS 572
             + K +     + ++P          P S  R   EM  + + G+   +++     PA 
Sbjct: 331 KQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEM--SYIDGEKVVKRSATLPLPAR 388

Query: 573 RPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPN---EQRPLREEVLPKEGVA---SKE 626
             +L+      +      E P     T +  A P    E +P +  VL  E ++   S E
Sbjct: 389 SSSLKSSSERND-----WEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPE 443

Query: 627 EVTLKEE-------------LPPKE---------EVAPKEEVPPIERAFAQKTRPIKPPP 664
           E+ LK E              PPK+          + P+E+         +K+  I P P
Sbjct: 444 EIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPRED---------RKSSAISPTP 494

Query: 665 D-SQETLALPSLVPQNYTENKNEGV--DVTSLRGEVESLRRALELMEVQLE 712
           + S ET         +  + +++G   D+TSL  E +  +  LE  ++ L+
Sbjct: 495 EISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQ 545


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 114/470 (24%), Positives = 164/470 (34%), Gaps = 77/470 (16%)

Query: 239 PPPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRD 296
           P P   K  P     +E AP   KEP    PK   PT  K    TT  S   T + P+  
Sbjct: 247 PAPTTTKSAP--TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 304

Query: 297 SQK----LTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-APSVK 351
           + K     T ++  P              K     TP++ + +++E   ++P + AP+  
Sbjct: 305 TPKKPAPTTPKEPAPTTP-----------KEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP 353

Query: 352 RTPMPDKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPA 409
           + P P     P      E AP++ K P+P   K P+P  T +       P  +T+   P 
Sbjct: 354 KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPT 413

Query: 410 PDKVPTPEKM-----VTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPM 464
             K P+P         TP++ A        P  T     P+TP+     E +P     P 
Sbjct: 414 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP-TTPKEPAPTTPK-----EPAPTTTKKPA 467

Query: 465 DKVP-NPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKED 523
              P  P      + APT  K LTP   E+   T  +                    K  
Sbjct: 468 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE--------------------KPA 507

Query: 524 PSSQEE--AHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHP 581
           P++ EE    TPE P P  P  E      K         P     K    + P  ++P P
Sbjct: 508 PTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP--KEPAP 564

Query: 582 HEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP------ 635
                T P         T +E AP   ++P  +E+ P     +KE  +   + P      
Sbjct: 565 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP---TTTKEPTSTTCDKPAPTTPK 621

Query: 636 ------PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVP 677
                 PKE     PKE  P   +  A  T   +P P + +  A   L P
Sbjct: 622 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKKPAPKELAP 670



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 120/494 (24%), Positives = 173/494 (35%), Gaps = 60/494 (12%)

Query: 239 PPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ 298
           P  P   L P    S+E++ +   K+   +T   T     T+T G  K  TS   ++  +
Sbjct: 123 PINPRPSLPPNSDTSKETS-LTVNKETTVETKETTTTNKQTSTDGKEKT-TSAKETQSIE 180

Query: 299 KLTSRDSGPNGGF----------QSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-A 347
           K +++D  P               + G      K     TP++ + ++ +E   + +K A
Sbjct: 181 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 240

Query: 348 PSVKRTPMPDKT----ATPERP-------PAP----ENAPSSKKIPAPDKVPS----PEK 388
           P+  + P P  T     TP+ P       PAP    E AP++ K PAP    S    P++
Sbjct: 241 PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 300

Query: 389 TLTLGDKASIPGNSTSGKIPAP--DKVPTPEKMVTPEDKASIPENSIIPEETLTVDK--- 443
                 K   P   T+ K PAP   K PTP     P      P  +   E   T  K   
Sbjct: 301 PAPTTPKKPAP---TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 357

Query: 444 PSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQF 503
           P+TP+       +P   AP   K P+P      + APT  K       E   +T      
Sbjct: 358 PTTPKE--PAPTTPKEPAPTTTKEPSPTTPK--EPAPTTTKSAPTTTKEPAPTTTKSAPT 413

Query: 504 HHFSSEEALQKVKYFVAKEDPS----SQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDS 559
                     K       ++P+     +    TP+ P P  P         K        
Sbjct: 414 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE 473

Query: 560 SPRQAELKSGPASRPALEKPHPHEEATTLPEE-APSNDER----TPEEEAP--PNEQRPL 612
                  ++ P +   L    P + A T PE+ AP+  E     TPEE  P  P E  P 
Sbjct: 474 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 533

Query: 613 REEVLPKEGVASKEEVTLKEELP--PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQE 668
             +             T KE  P  PKE     PKE  P   +  A  T   +P P + +
Sbjct: 534 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLK-EPAPTTPK 592

Query: 669 TLALPSLVPQNYTE 682
             A   L P    E
Sbjct: 593 KPAPKELAPTTTKE 606



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 103/456 (22%), Positives = 176/456 (38%), Gaps = 53/456 (11%)

Query: 240 PPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDS 297
           P P     P     + +AP   KEP    PK   PT  K    TT     +T+ T  + +
Sbjct: 522 PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT---PKETAPTTPKGT 578

Query: 298 QKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPV-KAPSVKRTPMP 356
              T ++  P    +        ++ + T T +  S +  +   ++P   AP+  + P P
Sbjct: 579 APTTLKEPAPTTPKKPAP-----KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 633

Query: 357 DKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPAP---- 410
                P        AP++ K PAP   K P+P++      K   P ++TS K PAP    
Sbjct: 634 TTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG--PTSTTSDK-PAPTTPK 690

Query: 411 DKVPTPEKM---VTPEDKA-SIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDK 466
           +  PT  K     TP+  A + PE    P  T  V  P+T +   ++ +SP    P +  
Sbjct: 691 ETAPTTPKEPAPTTPKKPAPTTPETP--PPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 748

Query: 467 VPNPKMAPLGDEAPTLEKVLTPELSEEEVST--RDDIQFHHFSSEEALQKVKYFVAKEDP 524
            P PK      + P +    TP  ++ E++T  +D        +          + KE  
Sbjct: 749 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 808

Query: 525 SSQE---EAHTPEAPPPQPPSSERCLGEMKCTLVRGDS-SPRQAELKSGPASRPALEKPH 580
           ++ E   E+           ++ +     K T ++  + +P+    K    +   + KP 
Sbjct: 809 TTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKP- 867

Query: 581 PHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEV 640
              E T  P++  +N + T      P  Q+P +    PK+  ++K+  T+     PK   
Sbjct: 868 ---EETAKPKDRATNSKAT-----TPKPQKPTK---APKKPTSTKKPKTMPRVRKPKTTP 916

Query: 641 APKE------EVPPIER---AFAQKTRPIKPPPDSQ 667
            P++      E+ P  R   A  Q T      P+S+
Sbjct: 917 TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSK 952



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 67/297 (22%), Positives = 108/297 (36%), Gaps = 47/297 (15%)

Query: 240  PPPIKKLVPRKVVSRESAPI-KEPKKLMPKTSL-PTVKKLATATTGPSKAKTSRTPSRD- 296
            PPP    V     ++E   I K P +  P+ S  PT K L  +   P    T++TP+   
Sbjct: 716  PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG-VPTTKTPAATK 774

Query: 297  -------SQKLTSRD---------SGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEE 340
                     K T RD         + P    ++  +     +   T T  Q  V+S   +
Sbjct: 775  PEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ--VTSTTTQ 832

Query: 341  HSSPVKAPSVKRTPMPDKTATPER---------PPAPENAPSSKKIPAPDKVPSPEKTLT 391
             ++P K  ++K T +  K  T ++          P     P  +   +    P P+K   
Sbjct: 833  DTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 892

Query: 392  LGDK-ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERV 450
               K  S     T  ++  P   PTP KM +   + + P + I      T  +P+     
Sbjct: 893  APKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN-PTSRIAEAMLQTTTRPNQTPNS 951

Query: 451  FSVEESPAL--------EAPPMDKVPN---PKMAPLGDEAPTLEK---VLTPELSEE 493
              VE +P          E P M   P+   P++ P  D  P +     ++ P LS+E
Sbjct: 952  KLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1008


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 114/470 (24%), Positives = 164/470 (34%), Gaps = 77/470 (16%)

Query: 239 PPPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRD 296
           P P   K  P     +E AP   KEP    PK   PT  K    TT  S   T + P+  
Sbjct: 288 PAPTTTKSAP--TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 345

Query: 297 SQK----LTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-APSVK 351
           + K     T ++  P              K     TP++ + +++E   ++P + AP+  
Sbjct: 346 TPKKPAPTTPKEPAPTTP-----------KEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP 394

Query: 352 RTPMPDKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPA 409
           + P P     P      E AP++ K P+P   K P+P  T +       P  +T+   P 
Sbjct: 395 KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPT 454

Query: 410 PDKVPTPEKM-----VTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPM 464
             K P+P         TP++ A        P  T     P+TP+     E +P     P 
Sbjct: 455 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP-TTPKEPAPTTPK-----EPAPTTTKKPA 508

Query: 465 DKVP-NPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKED 523
              P  P      + APT  K LTP   E+   T  +                    K  
Sbjct: 509 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE--------------------KPA 548

Query: 524 PSSQEE--AHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHP 581
           P++ EE    TPE P P  P  E      K         P     K    + P  ++P P
Sbjct: 549 PTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP--KEPAP 605

Query: 582 HEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP------ 635
                T P         T +E AP   ++P  +E+ P     +KE  +   + P      
Sbjct: 606 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP---TTTKEPTSTTCDKPAPTTPK 662

Query: 636 ------PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVP 677
                 PKE     PKE  P   +  A  T   +P P + +  A   L P
Sbjct: 663 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKKPAPKELAP 711



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 120/494 (24%), Positives = 173/494 (35%), Gaps = 60/494 (12%)

Query: 239 PPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ 298
           P  P   L P    S+E++ +   K+   +T   T     T+T G  K  TS   ++  +
Sbjct: 164 PINPRPSLPPNSDTSKETS-LTVNKETTVETKETTTTNKQTSTDGKEKT-TSAKETQSIE 221

Query: 299 KLTSRDSGPNGGF----------QSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-A 347
           K +++D  P               + G      K     TP++ + ++ +E   + +K A
Sbjct: 222 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 281

Query: 348 PSVKRTPMPDKT----ATPERP-------PAP----ENAPSSKKIPAPDKVPS----PEK 388
           P+  + P P  T     TP+ P       PAP    E AP++ K PAP    S    P++
Sbjct: 282 PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 341

Query: 389 TLTLGDKASIPGNSTSGKIPAP--DKVPTPEKMVTPEDKASIPENSIIPEETLTVDK--- 443
                 K   P   T+ K PAP   K PTP     P      P  +   E   T  K   
Sbjct: 342 PAPTTPKKPAP---TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 398

Query: 444 PSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQF 503
           P+TP+       +P   AP   K P+P      + APT  K       E   +T      
Sbjct: 399 PTTPKE--PAPTTPKEPAPTTTKEPSPTTPK--EPAPTTTKSAPTTTKEPAPTTTKSAPT 454

Query: 504 HHFSSEEALQKVKYFVAKEDPS----SQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDS 559
                     K       ++P+     +    TP+ P P  P         K        
Sbjct: 455 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE 514

Query: 560 SPRQAELKSGPASRPALEKPHPHEEATTLPEE-APSNDER----TPEEEAP--PNEQRPL 612
                  ++ P +   L    P + A T PE+ AP+  E     TPEE  P  P E  P 
Sbjct: 515 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 574

Query: 613 REEVLPKEGVASKEEVTLKEELP--PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQE 668
             +             T KE  P  PKE     PKE  P   +  A  T   +P P + +
Sbjct: 575 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLK-EPAPTTPK 633

Query: 669 TLALPSLVPQNYTE 682
             A   L P    E
Sbjct: 634 KPAPKELAPTTTKE 647



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 103/456 (22%), Positives = 176/456 (38%), Gaps = 53/456 (11%)

Query: 240 PPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDS 297
           P P     P     + +AP   KEP    PK   PT  K    TT     +T+ T  + +
Sbjct: 563 PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT---PKETAPTTPKGT 619

Query: 298 QKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPV-KAPSVKRTPMP 356
              T ++  P    +        ++ + T T +  S +  +   ++P   AP+  + P P
Sbjct: 620 APTTLKEPAPTTPKKPAP-----KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 674

Query: 357 DKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPAP---- 410
                P        AP++ K PAP   K P+P++      K   P ++TS K PAP    
Sbjct: 675 TTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG--PTSTTSDK-PAPTTPK 731

Query: 411 DKVPTPEKM---VTPEDKA-SIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDK 466
           +  PT  K     TP+  A + PE    P  T  V  P+T +   ++ +SP    P +  
Sbjct: 732 ETAPTTPKEPAPTTPKKPAPTTPETP--PPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 789

Query: 467 VPNPKMAPLGDEAPTLEKVLTPELSEEEVST--RDDIQFHHFSSEEALQKVKYFVAKEDP 524
            P PK      + P +    TP  ++ E++T  +D        +          + KE  
Sbjct: 790 EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 849

Query: 525 SSQE---EAHTPEAPPPQPPSSERCLGEMKCTLVRGDS-SPRQAELKSGPASRPALEKPH 580
           ++ E   E+           ++ +     K T ++  + +P+    K    +   + KP 
Sbjct: 850 TTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKP- 908

Query: 581 PHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEV 640
              E T  P++  +N + T      P  Q+P +    PK+  ++K+  T+     PK   
Sbjct: 909 ---EETAKPKDRATNSKAT-----TPKPQKPTK---APKKPTSTKKPKTMPRVRKPKTTP 957

Query: 641 APKE------EVPPIER---AFAQKTRPIKPPPDSQ 667
            P++      E+ P  R   A  Q T      P+S+
Sbjct: 958 TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSK 993



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 67/297 (22%), Positives = 108/297 (36%), Gaps = 47/297 (15%)

Query: 240  PPPIKKLVPRKVVSRESAPI-KEPKKLMPKTSL-PTVKKLATATTGPSKAKTSRTPSRD- 296
            PPP    V     ++E   I K P +  P+ S  PT K L  +   P    T++TP+   
Sbjct: 757  PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG-VPTTKTPAATK 815

Query: 297  -------SQKLTSRD---------SGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEE 340
                     K T RD         + P    ++  +     +   T T  Q  V+S   +
Sbjct: 816  PEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ--VTSTTTQ 873

Query: 341  HSSPVKAPSVKRTPMPDKTATPER---------PPAPENAPSSKKIPAPDKVPSPEKTLT 391
             ++P K  ++K T +  K  T ++          P     P  +   +    P P+K   
Sbjct: 874  DTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 933

Query: 392  LGDK-ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERV 450
               K  S     T  ++  P   PTP KM +   + + P + I      T  +P+     
Sbjct: 934  APKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN-PTSRIAEAMLQTTTRPNQTPNS 992

Query: 451  FSVEESPAL--------EAPPMDKVPN---PKMAPLGDEAPTLEK---VLTPELSEE 493
              VE +P          E P M   P+   P++ P  D  P +     ++ P LS+E
Sbjct: 993  KLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1049


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 114/470 (24%), Positives = 164/470 (34%), Gaps = 77/470 (16%)

Query: 239 PPPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRD 296
           P P   K  P     +E AP   KEP    PK   PT  K    TT  S   T + P+  
Sbjct: 340 PAPTTTKSAP--TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 397

Query: 297 SQK----LTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-APSVK 351
           + K     T ++  P              K     TP++ + +++E   ++P + AP+  
Sbjct: 398 TPKKPAPTTPKEPAPTTP-----------KEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP 446

Query: 352 RTPMPDKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPA 409
           + P P     P      E AP++ K P+P   K P+P  T +       P  +T+   P 
Sbjct: 447 KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPT 506

Query: 410 PDKVPTPEKM-----VTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPM 464
             K P+P         TP++ A        P  T     P+TP+     E +P     P 
Sbjct: 507 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP-TTPKEPAPTTPK-----EPAPTTTKKPA 560

Query: 465 DKVP-NPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKED 523
              P  P      + APT  K LTP   E+   T  +                    K  
Sbjct: 561 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE--------------------KPA 600

Query: 524 PSSQEE--AHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHP 581
           P++ EE    TPE P P  P  E      K         P     K    + P  ++P P
Sbjct: 601 PTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP--KEPAP 657

Query: 582 HEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP------ 635
                T P         T +E AP   ++P  +E+ P     +KE  +   + P      
Sbjct: 658 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP---TTTKEPTSTTCDKPAPTTPK 714

Query: 636 ------PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVP 677
                 PKE     PKE  P   +  A  T   +P P + +  A   L P
Sbjct: 715 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKKPAPKELAP 763



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 120/494 (24%), Positives = 173/494 (35%), Gaps = 60/494 (12%)

Query: 239 PPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ 298
           P  P   L P    S+E++ +   K+   +T   T     T+T G  K  TS   ++  +
Sbjct: 216 PINPRPSLPPNSDTSKETS-LTVNKETTVETKETTTTNKQTSTDGKEKT-TSAKETQSIE 273

Query: 299 KLTSRDSGPNGGF----------QSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-A 347
           K +++D  P               + G      K     TP++ + ++ +E   + +K A
Sbjct: 274 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 333

Query: 348 PSVKRTPMPDKT----ATPERP-------PAP----ENAPSSKKIPAPDKVPS----PEK 388
           P+  + P P  T     TP+ P       PAP    E AP++ K PAP    S    P++
Sbjct: 334 PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 393

Query: 389 TLTLGDKASIPGNSTSGKIPAP--DKVPTPEKMVTPEDKASIPENSIIPEETLTVDK--- 443
                 K   P   T+ K PAP   K PTP     P      P  +   E   T  K   
Sbjct: 394 PAPTTPKKPAP---TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 450

Query: 444 PSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQF 503
           P+TP+       +P   AP   K P+P      + APT  K       E   +T      
Sbjct: 451 PTTPKE--PAPTTPKEPAPTTTKEPSPTTPK--EPAPTTTKSAPTTTKEPAPTTTKSAPT 506

Query: 504 HHFSSEEALQKVKYFVAKEDPS----SQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDS 559
                     K       ++P+     +    TP+ P P  P         K        
Sbjct: 507 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE 566

Query: 560 SPRQAELKSGPASRPALEKPHPHEEATTLPEE-APSNDER----TPEEEAP--PNEQRPL 612
                  ++ P +   L    P + A T PE+ AP+  E     TPEE  P  P E  P 
Sbjct: 567 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 626

Query: 613 REEVLPKEGVASKEEVTLKEELP--PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQE 668
             +             T KE  P  PKE     PKE  P   +  A  T   +P P + +
Sbjct: 627 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLK-EPAPTTPK 685

Query: 669 TLALPSLVPQNYTE 682
             A   L P    E
Sbjct: 686 KPAPKELAPTTTKE 699



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 103/456 (22%), Positives = 176/456 (38%), Gaps = 53/456 (11%)

Query: 240  PPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDS 297
            P P     P     + +AP   KEP    PK   PT  K    TT     +T+ T  + +
Sbjct: 615  PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT---PKETAPTTPKGT 671

Query: 298  QKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPV-KAPSVKRTPMP 356
               T ++  P    +        ++ + T T +  S +  +   ++P   AP+  + P P
Sbjct: 672  APTTLKEPAPTTPKKPAP-----KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 726

Query: 357  DKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPAP---- 410
                 P        AP++ K PAP   K P+P++      K   P ++TS K PAP    
Sbjct: 727  TTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG--PTSTTSDK-PAPTTPK 783

Query: 411  DKVPTPEKM---VTPEDKA-SIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDK 466
            +  PT  K     TP+  A + PE    P  T  V  P+T +   ++ +SP    P +  
Sbjct: 784  ETAPTTPKEPAPTTPKKPAPTTPETP--PPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 841

Query: 467  VPNPKMAPLGDEAPTLEKVLTPELSEEEVST--RDDIQFHHFSSEEALQKVKYFVAKEDP 524
             P PK      + P +    TP  ++ E++T  +D        +          + KE  
Sbjct: 842  EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 901

Query: 525  SSQE---EAHTPEAPPPQPPSSERCLGEMKCTLVRGDS-SPRQAELKSGPASRPALEKPH 580
            ++ E   E+           ++ +     K T ++  + +P+    K    +   + KP 
Sbjct: 902  TTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKP- 960

Query: 581  PHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEV 640
               E T  P++  +N + T      P  Q+P +    PK+  ++K+  T+     PK   
Sbjct: 961  ---EETAKPKDRATNSKAT-----TPKPQKPTK---APKKPTSTKKPKTMPRVRKPKTTP 1009

Query: 641  APKE------EVPPIER---AFAQKTRPIKPPPDSQ 667
             P++      E+ P  R   A  Q T      P+S+
Sbjct: 1010 TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSK 1045



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 87/379 (22%), Positives = 137/379 (36%), Gaps = 85/379 (22%)

Query: 340 EHSSPVKAPSVKRTPMPDKTA-----TPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGD 394
           E  +P   PS K+ P P   +     T +R P P N   +KK+   +++ + E +++   
Sbjct: 65  EVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEI-TEEHSVSENQ 123

Query: 395 KASIPGNSTSG---------------------KIPAPD-------KVPTPEKMVTPEDKA 426
           ++S   +S+S                      K+   D       K PTP+  V  E  +
Sbjct: 124 ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 183

Query: 427 SIPENSIIPEETLTVDKPSTPERVFSVEESPAL-EAPPMDKVPNPKMAPLGDEAP----T 481
            +        +  T D  +T      V  SP +  A P++  P P + P  D +     T
Sbjct: 184 GLDNGDF---KVTTPDTSTTQHN--KVSTSPKITTAKPIN--PRPSLPPNSDTSKETSLT 236

Query: 482 LEKVLTPELSE-------------EEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQE 528
           + K  T E  E             E+ ++  + Q    +S + L      +AK  P ++ 
Sbjct: 237 VNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAET 296

Query: 529 EAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTL 588
               P    P+ P+          T       P    +KS P +        P E A T 
Sbjct: 297 TTKGPALTTPKEPTPTTPKEPASTT----PKEPTPTTIKSAPTT--------PKEPAPTT 344

Query: 589 PEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVA---PKEE 645
            + AP+    TP+E AP   + P      PKE   +    T KE  P   + A   PKE 
Sbjct: 345 TKSAPT----TPKEPAPTTTKEP--APTTPKEPAPT----TTKEPAPTTTKSAPTTPKEP 394

Query: 646 VPPIERAFAQKTRPIKPPP 664
            P   +  A  T P +P P
Sbjct: 395 APTTPKKPA-PTTPKEPAP 412



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 67/297 (22%), Positives = 108/297 (36%), Gaps = 47/297 (15%)

Query: 240  PPPIKKLVPRKVVSRESAPI-KEPKKLMPKTSL-PTVKKLATATTGPSKAKTSRTPSRD- 296
            PPP    V     ++E   I K P +  P+ S  PT K L  +   P    T++TP+   
Sbjct: 809  PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG-VPTTKTPAATK 867

Query: 297  -------SQKLTSRD---------SGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEE 340
                     K T RD         + P    ++  +     +   T T  Q  V+S   +
Sbjct: 868  PEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ--VTSTTTQ 925

Query: 341  HSSPVKAPSVKRTPMPDKTATPER---------PPAPENAPSSKKIPAPDKVPSPEKTLT 391
             ++P K  ++K T +  K  T ++          P     P  +   +    P P+K   
Sbjct: 926  DTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 985

Query: 392  LGDK-ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERV 450
               K  S     T  ++  P   PTP KM +   + + P + I      T  +P+     
Sbjct: 986  APKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN-PTSRIAEAMLQTTTRPNQTPNS 1044

Query: 451  FSVEESPAL--------EAPPMDKVPN---PKMAPLGDEAPTLEK---VLTPELSEE 493
              VE +P          E P M   P+   P++ P  D  P +     ++ P LS+E
Sbjct: 1045 KLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1101


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 114/470 (24%), Positives = 164/470 (34%), Gaps = 77/470 (16%)

Query: 239 PPPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRD 296
           P P   K  P     +E AP   KEP    PK   PT  K    TT  S   T + P+  
Sbjct: 381 PAPTTTKSAP--TTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPT 438

Query: 297 SQK----LTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-APSVK 351
           + K     T ++  P              K     TP++ + +++E   ++P + AP+  
Sbjct: 439 TPKKPAPTTPKEPAPTTP-----------KEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP 487

Query: 352 RTPMPDKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPA 409
           + P P     P      E AP++ K P+P   K P+P  T +       P  +T+   P 
Sbjct: 488 KKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPT 547

Query: 410 PDKVPTPEKM-----VTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPM 464
             K P+P         TP++ A        P  T     P+TP+     E +P     P 
Sbjct: 548 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP-TTPKEPAPTTPK-----EPAPTTTKKPA 601

Query: 465 DKVP-NPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSSEEALQKVKYFVAKED 523
              P  P      + APT  K LTP   E+   T  +                    K  
Sbjct: 602 PTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPE--------------------KPA 641

Query: 524 PSSQEE--AHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHP 581
           P++ EE    TPE P P  P  E      K         P     K    + P  ++P P
Sbjct: 642 PTTPEELAPTTPEEPTPTTP-EEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTP--KEPAP 698

Query: 582 HEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP------ 635
                T P         T +E AP   ++P  +E+ P     +KE  +   + P      
Sbjct: 699 TTPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAP---TTTKEPTSTTCDKPAPTTPK 755

Query: 636 ------PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVP 677
                 PKE     PKE  P   +  A  T   +P P + +  A   L P
Sbjct: 756 GTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK-EPAPTTPKKPAPKELAP 804



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 120/494 (24%), Positives = 173/494 (35%), Gaps = 60/494 (12%)

Query: 239 PPPPIKKLVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ 298
           P  P   L P    S+E++ +   K+   +T   T     T+T G  K  TS   ++  +
Sbjct: 257 PINPRPSLPPNSDTSKETS-LTVNKETTVETKETTTTNKQTSTDGKEKT-TSAKETQSIE 314

Query: 299 KLTSRDSGPNGGF----------QSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVK-A 347
           K +++D  P               + G      K     TP++ + ++ +E   + +K A
Sbjct: 315 KTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSA 374

Query: 348 PSVKRTPMPDKT----ATPERP-------PAP----ENAPSSKKIPAPDKVPS----PEK 388
           P+  + P P  T     TP+ P       PAP    E AP++ K PAP    S    P++
Sbjct: 375 PTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKE 434

Query: 389 TLTLGDKASIPGNSTSGKIPAP--DKVPTPEKMVTPEDKASIPENSIIPEETLTVDK--- 443
                 K   P   T+ K PAP   K PTP     P      P  +   E   T  K   
Sbjct: 435 PAPTTPKKPAP---TTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPA 491

Query: 444 PSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQF 503
           P+TP+       +P   AP   K P+P      + APT  K       E   +T      
Sbjct: 492 PTTPKE--PAPTTPKEPAPTTTKEPSPTTPK--EPAPTTTKSAPTTTKEPAPTTTKSAPT 547

Query: 504 HHFSSEEALQKVKYFVAKEDPS----SQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDS 559
                     K       ++P+     +    TP+ P P  P         K        
Sbjct: 548 TPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKE 607

Query: 560 SPRQAELKSGPASRPALEKPHPHEEATTLPEE-APSNDER----TPEEEAP--PNEQRPL 612
                  ++ P +   L    P + A T PE+ AP+  E     TPEE  P  P E  P 
Sbjct: 608 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 667

Query: 613 REEVLPKEGVASKEEVTLKEELP--PKE--EVAPKEEVPPIERAFAQKTRPIKPPPDSQE 668
             +             T KE  P  PKE     PKE  P   +  A  T   +P P + +
Sbjct: 668 TPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLK-EPAPTTPK 726

Query: 669 TLALPSLVPQNYTE 682
             A   L P    E
Sbjct: 727 KPAPKELAPTTTKE 740



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 103/456 (22%), Positives = 176/456 (38%), Gaps = 53/456 (11%)

Query: 240  PPPIKKLVPRKVVSRESAPI--KEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDS 297
            P P     P     + +AP   KEP    PK   PT  K    TT     +T+ T  + +
Sbjct: 656  PTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT---PKETAPTTPKGT 712

Query: 298  QKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPV-KAPSVKRTPMP 356
               T ++  P    +        ++ + T T +  S +  +   ++P   AP+  + P P
Sbjct: 713  APTTLKEPAPTTPKKPAP-----KELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAP 767

Query: 357  DKTATPERPPAPENAPSSKKIPAPD--KVPSPEKTLTLGDKASIPGNSTSGKIPAP---- 410
                 P        AP++ K PAP   K P+P++      K   P ++TS K PAP    
Sbjct: 768  TTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKG--PTSTTSDK-PAPTTPK 824

Query: 411  DKVPTPEKM---VTPEDKA-SIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDK 466
            +  PT  K     TP+  A + PE    P  T  V  P+T +   ++ +SP    P +  
Sbjct: 825  ETAPTTPKEPAPTTPKKPAPTTPETP--PPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 882

Query: 467  VPNPKMAPLGDEAPTLEKVLTPELSEEEVST--RDDIQFHHFSSEEALQKVKYFVAKEDP 524
             P PK      + P +    TP  ++ E++T  +D        +          + KE  
Sbjct: 883  EPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETA 942

Query: 525  SSQE---EAHTPEAPPPQPPSSERCLGEMKCTLVRGDS-SPRQAELKSGPASRPALEKPH 580
            ++ E   E+           ++ +     K T ++  + +P+    K    +   + KP 
Sbjct: 943  TTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKP- 1001

Query: 581  PHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEV 640
               E T  P++  +N + T      P  Q+P +    PK+  ++K+  T+     PK   
Sbjct: 1002 ---EETAKPKDRATNSKAT-----TPKPQKPTK---APKKPTSTKKPKTMPRVRKPKTTP 1050

Query: 641  APKE------EVPPIER---AFAQKTRPIKPPPDSQ 667
             P++      E+ P  R   A  Q T      P+S+
Sbjct: 1051 TPRKMTSTMPELNPTSRIAEAMLQTTTRPNQTPNSK 1086



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 87/379 (22%), Positives = 137/379 (36%), Gaps = 85/379 (22%)

Query: 340 EHSSPVKAPSVKRTPMPDKTA-----TPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGD 394
           E  +P   PS K+ P P   +     T +R P P N   +KK+   +++ + E +++   
Sbjct: 106 EVHNPTSPPSSKKAPPPSGASQTIKSTTKRSPKPPNKKKTKKVIESEEI-TEEHSVSENQ 164

Query: 395 KASIPGNSTSG---------------------KIPAPD-------KVPTPEKMVTPEDKA 426
           ++S   +S+S                      K+   D       K PTP+  V  E  +
Sbjct: 165 ESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTKKKPTPKPPVVDEAGS 224

Query: 427 SIPENSIIPEETLTVDKPSTPERVFSVEESPAL-EAPPMDKVPNPKMAPLGDEAP----T 481
            +        +  T D  +T      V  SP +  A P++  P P + P  D +     T
Sbjct: 225 GLDNGDF---KVTTPDTSTTQHN--KVSTSPKITTAKPIN--PRPSLPPNSDTSKETSLT 277

Query: 482 LEKVLTPELSE-------------EEVSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQE 528
           + K  T E  E             E+ ++  + Q    +S + L      +AK  P ++ 
Sbjct: 278 VNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAKPTPKAET 337

Query: 529 EAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKSGPASRPALEKPHPHEEATTL 588
               P    P+ P+          T       P    +KS P +        P E A T 
Sbjct: 338 TTKGPALTTPKEPTPTTPKEPASTT----PKEPTPTTIKSAPTT--------PKEPAPTT 385

Query: 589 PEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELPPKEEVA---PKEE 645
            + AP+    TP+E AP   + P      PKE   +    T KE  P   + A   PKE 
Sbjct: 386 TKSAPT----TPKEPAPTTTKEP--APTTPKEPAPT----TTKEPAPTTTKSAPTTPKEP 435

Query: 646 VPPIERAFAQKTRPIKPPP 664
            P   +  A  T P +P P
Sbjct: 436 APTTPKKPA-PTTPKEPAP 453



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 67/297 (22%), Positives = 108/297 (36%), Gaps = 47/297 (15%)

Query: 240  PPPIKKLVPRKVVSRESAPI-KEPKKLMPKTSL-PTVKKLATATTGPSKAKTSRTPSRD- 296
            PPP    V     ++E   I K P +  P+ S  PT K L  +   P    T++TP+   
Sbjct: 850  PPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPG-VPTTKTPAATK 908

Query: 297  -------SQKLTSRD---------SGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEE 340
                     K T RD         + P    ++  +     +   T T  Q  V+S   +
Sbjct: 909  PEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQ--VTSTTTQ 966

Query: 341  HSSPVKAPSVKRTPMPDKTATPER---------PPAPENAPSSKKIPAPDKVPSPEKTLT 391
             ++P K  ++K T +  K  T ++          P     P  +   +    P P+K   
Sbjct: 967  DTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTK 1026

Query: 392  LGDK-ASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERV 450
               K  S     T  ++  P   PTP KM +   + + P + I      T  +P+     
Sbjct: 1027 APKKPTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELN-PTSRIAEAMLQTTTRPNQTPNS 1085

Query: 451  FSVEESPAL--------EAPPMDKVPN---PKMAPLGDEAPTLEK---VLTPELSEE 493
              VE +P          E P M   P+   P++ P  D  P +     ++ P LS+E
Sbjct: 1086 KLVEVNPKSEDAGGAEGETPHMLLRPHVFMPEVTPDMDYLPRVPNQGIIINPMLSDE 1142


>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
          Length = 825

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 120/500 (24%), Positives = 193/500 (38%), Gaps = 93/500 (18%)

Query: 249 RKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDSGPN 308
           +KV S E  P    K   P    P + + ATA   P  A+ +    + S + T       
Sbjct: 250 KKVASAEIEPPSTEK--FPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAAT 307

Query: 309 GGFQSGGSYHP--GRKRSKTQTPQQRSVSSQEEEHSSPVKA----PSVKRTPMPDKTATP 362
              ++     P    +    + P +    S EE  S  + A    PS + +P  +  A  
Sbjct: 308 AVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEI 367

Query: 363 ERPPAPEN----------APSSKKIP--------------APDKVPSPEKTLTLGDKASI 398
             PPA ++          +PS++K P              AP KV  P    TL D   +
Sbjct: 368 LPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPL 427

Query: 399 PGNSTSGKIPAPDKVPTPEK--------MVTPEDKASIPENSIIPEETLTVDKPSTPERV 450
                      P++ P  E         M TP ++A     S +P+ET T ++ S   ++
Sbjct: 428 ----------LPEEAPREEARELQLSTAMETPAEEAPTEFQSPLPKET-TAEEASAEIQL 476

Query: 451 FSVEESPALEAPPMDKVPNPKMAPLGDEAPTLE---KVLTPELSEEEVSTRDDIQFHHFS 507
            +  E      PP D+ P    +PL +E    E   +V +P L+EE             +
Sbjct: 477 LAATE------PPADETPAEARSPLSEETSAEEAHAEVQSP-LAEET------------T 517

Query: 508 SEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRG---DSSPRQA 564
           +EEA  +++   A E P+ +  A   ++P  +  S+E    E++    +G   + +P + 
Sbjct: 518 AEEASAEIQLLAAIEAPADETPAEA-QSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL 576

Query: 565 ELKSGP--------------ASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQR 610
           +  SG               A+  A  +  P E      EEAP+  +  P EEAP   Q 
Sbjct: 577 QPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQP 636

Query: 611 PLREEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQ-KTRPIKPPPDSQET 669
           P  EE   +      EE   + + PP EE   + + PP E A A+ ++ P +  P  +ET
Sbjct: 637 PPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEETP-IEET 695

Query: 670 LALPSLVPQNYTENKNEGVD 689
           LA     P +    +   VD
Sbjct: 696 LAAVHSPPADDVPAEEASVD 715



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 112/486 (23%), Positives = 183/486 (37%), Gaps = 69/486 (14%)

Query: 286 KAKTSRTPSRDSQKLTSRDSGPNG--GFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSS 343
           K K    P   S K T R    +G  G  S  +Y   R  S+ Q    +    QE    S
Sbjct: 13  KKKHMAIPKSSSPKATHRIGNTSGSKGSYSAKAYESIRVSSELQQTWTKRKHGQEMTSKS 72

Query: 344 ---------PVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGD 394
                      +   V+ T +P++ +   R  A E   S + +  P  +PS +  +    
Sbjct: 73  LQTDTIVEEKKEVKLVEETVVPEEKSADVREAAIELPESVQDVEIPPNIPSVQLKMDRSQ 132

Query: 395 KASIPGNSTSGKIPAPDKVPTPEKMVTPEDK---ASIPENSIIPEETLTVDKPSTPERVF 451
           + S  G  T   IP  +KV   ++    E +    S P++S    +   + K  +  ++F
Sbjct: 133 QTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSKEDAL-KHKSSGKIF 191

Query: 452 SVEE---SPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEEVSTRDDIQFHHFSS 508
           + E     PA  +       N        E     K   P L E+E+  R+++       
Sbjct: 192 ASEHPEFQPATNSNEEIGQKNISRTSFTQET----KKGPPVLLEDEL--REEVTVPVVQE 245

Query: 509 EEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDSSPRQAELKS 568
             A++KV                   +   +PPS+E+   +++  LV       +A  K+
Sbjct: 246 GSAVKKV------------------ASAEIEPPSTEKFPAKIQPPLV------EEATAKA 281

Query: 569 GPASRPALE---KPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLRE---EVLPKEGV 622
            P  RPA E   +  P  E T   E A +  E + + + PP E+ PL E   E+ P    
Sbjct: 282 EP--RPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAE 339

Query: 623 ASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLALPSLVPQNYTE 682
            S     L E LPP  E +P EE PP E         I PPP ++++ ++  L       
Sbjct: 340 ESPSVELLAEILPPSAEESPSEE-PPAE---------ILPPP-AEKSPSVELLGEIRSPS 388

Query: 683 NKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSE--KEQRRRLEVQVMQGT 740
            +   ++V  L  E        ++    +E  L D+   L  E  +E+ R L++     T
Sbjct: 389 AQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMET 448

Query: 741 QKSQTP 746
              + P
Sbjct: 449 PAEEAP 454


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.129    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,855,021
Number of Sequences: 37866
Number of extensions: 2453601
Number of successful extensions: 24311
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 368
Number of HSP's successfully gapped in prelim test: 1481
Number of HSP's that attempted gapping in prelim test: 13873
Number of HSP's gapped (non-prelim): 7538
length of query: 756
length of database: 18,247,518
effective HSP length: 110
effective length of query: 646
effective length of database: 14,082,258
effective search space: 9097138668
effective search space used: 9097138668
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.