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Search of human proteins with 119433677
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
(988 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens] 1994 0.0
gi|156104869 chloride channel 2 [Homo sapiens] 869 0.0
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens] 490 e-138
gi|112382222 chloride channel Ka isoform 2 [Homo sapiens] 490 e-138
gi|155969705 chloride channel Kb [Homo sapiens] 481 e-135
gi|189217923 chloride channel 5 isoform a [Homo sapiens] 209 1e-53
gi|189217921 chloride channel 5 isoform a [Homo sapiens] 209 1e-53
gi|4557473 chloride channel 5 isoform b [Homo sapiens] 209 1e-53
gi|153252026 chloride channel 4 [Homo sapiens] 201 2e-51
gi|55770840 chloride channel 3 isoform e [Homo sapiens] 195 2e-49
gi|55770838 chloride channel 3 isoform b [Homo sapiens] 195 2e-49
gi|167466160 chloride channel 7 isoform b [Homo sapiens] 183 8e-46
gi|14149607 chloride channel 7 isoform a [Homo sapiens] 183 8e-46
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens] 165 2e-40
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens] 103 1e-21
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens] 73 2e-12
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens] 73 2e-12
gi|239757093 PREDICTED: hypothetical protein [Homo sapiens] 39 0.031
gi|239751599 PREDICTED: hypothetical protein XP_002347926 [Homo ... 39 0.031
gi|239746114 PREDICTED: hypothetical protein XP_002344193 [Homo ... 39 0.031
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 38 0.041
gi|122937289 kinesin family member 18B [Homo sapiens] 38 0.054
gi|54860079 nadrin isoform 1 [Homo sapiens] 37 0.091
gi|54860105 nadrin isoform 2 [Homo sapiens] 37 0.091
gi|53831995 splicing factor 3a, subunit 1, 120kDa isoform 2 [Hom... 37 0.091
gi|5032087 splicing factor 3a, subunit 1, 120kDa isoform 1 [Homo... 37 0.091
gi|157785645 SPEG complex locus [Homo sapiens] 37 0.091
gi|30795231 brain abundant, membrane attached signal protein 1 [... 37 0.12
gi|116268091 PHD finger protein 23 [Homo sapiens] 36 0.16
gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens] 36 0.16
>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
Length = 988
Score = 1994 bits (5165), Expect = 0.0
Identities = 988/988 (100%), Positives = 988/988 (100%)
Query: 1 MEQSRSQQRGGEQSWWGSDPQYQYMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHPTQ 60
MEQSRSQQRGGEQSWWGSDPQYQYMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHPTQ
Sbjct: 1 MEQSRSQQRGGEQSWWGSDPQYQYMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHPTQ 60
Query: 61 IYGHHKEQFSDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIF 120
IYGHHKEQFSDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIF
Sbjct: 61 IYGHHKEQFSDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIF 120
Query: 121 LVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCH 180
LVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCH
Sbjct: 121 LVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCH 180
Query: 181 LISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIAS 240
LISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIAS
Sbjct: 181 LISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIAS 240
Query: 241 ICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVR 300
ICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVR
Sbjct: 241 ICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVR 300
Query: 301 NYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGL 360
NYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGL
Sbjct: 301 NYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGL 360
Query: 361 LGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMP 420
LGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMP
Sbjct: 361 LGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMP 420
Query: 421 REAISTLFDNNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIP 480
REAISTLFDNNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIP
Sbjct: 421 REAISTLFDNNTWVKHAGDPESLGQSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIP 480
Query: 481 CGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTV 540
CGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTV
Sbjct: 481 CGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTV 540
Query: 541 STAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSK 600
STAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSK
Sbjct: 541 STAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSK 600
Query: 601 YTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQAL 660
YTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQAL
Sbjct: 601 YTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQAL 660
Query: 661 LQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLS 720
LQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLS
Sbjct: 661 LQRHLCPERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLS 720
Query: 721 GKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRAR 780
GKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRAR
Sbjct: 721 GKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRAR 780
Query: 781 PTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTL 840
PTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTL
Sbjct: 781 PTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTL 840
Query: 841 FSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAP 900
FSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAP
Sbjct: 841 FSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAP 900
Query: 901 PSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEELELVESP 960
PSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEELELVESP
Sbjct: 901 PSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEELELVESP 960
Query: 961 GLEEELADILQGPSLRSTDEEDEDELIL 988
GLEEELADILQGPSLRSTDEEDEDELIL
Sbjct: 961 GLEEELADILQGPSLRSTDEEDEDELIL 988
>gi|156104869 chloride channel 2 [Homo sapiens]
Length = 898
Score = 869 bits (2246), Expect = 0.0
Identities = 460/809 (56%), Positives = 573/809 (70%), Gaps = 19/809 (2%)
Query: 97 SKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPS 156
++C+ C R + + ++GEDWIFLVLLGLLMALVSW MDY A LQA +W + S
Sbjct: 70 ARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTS 129
Query: 157 LPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKV 216
+ LQ+L WVT+P+VLI FSA F +++PQAVGSGIPEMKTILRGVVLKEYLT+K F+AKV
Sbjct: 130 ILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKV 189
Query: 217 VALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVG 276
+ LT LGSG+P+GKEGPFVHIAS+CAA+LSKF+S+F G+YE +++L CAVGVG
Sbjct: 190 IGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVG 249
Query: 277 CCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTN 336
CCF P+GGVLFSIEVTST+FAVRNYWRGFFAATFSAF+FRVLAVWN+D TITALF+T
Sbjct: 250 CCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTR 309
Query: 337 FRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGI 396
FR+DFPFDL+ELPAFA IGI G GA+FVYL+R+++ +RK K +++FL + RLL+P +
Sbjct: 310 FRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPAL 369
Query: 397 VTFVIASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKH--AGDPESLGQSAVWIHPRV 454
VT +I++ TFPPG GQFMAG+L +E + TLFDN TWV+ + E S W PR
Sbjct: 370 VTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTWVRQGLVEELEPPSTSQAWNPPRA 429
Query: 455 NVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDD 514
NV + + +F +MKFWMS +ATT+P+PCG FMPVFV+GAAFGRLVGE MA FPDGI D
Sbjct: 430 NVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDS 489
Query: 515 IIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQ 574
Y+I+PGGYAV+GAAAL GAV+HTVSTAVI FELTGQIAHILP+M+AVILAN VAQSLQ
Sbjct: 490 STYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQ 549
Query: 575 PSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTV 634
PSLYDSII++KKLPYLP+LGW + +Y + VEDIMVRDV V+ S T+ +LR L T
Sbjct: 550 PSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKG 609
Query: 635 KTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAAQEMARKLSELPYDGKARLAG 694
+ L LV+S +SMILLGS+ERS++ ALL L P RR + QE R P +
Sbjct: 610 RMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQE-RRATQTSPLSDQ----- 663
Query: 695 EGLPGAPPGRPESFAFVDEDEDEDL---SGKSELP--PSLALHPSTTAPLSPEEPNGPLP 749
EG PP S F ED G++ P P+L PS T L E P G
Sbjct: 664 EG----PPTPEASVCFQVNTEDSAFPAARGETHKPLKPALKRGPSVTRNLG-ESPTGSAE 718
Query: 750 GHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQ 809
+ P L R + + DL MSPEEI WE++Q
Sbjct: 719 SAGIALRSLFCGSPPPEAASEKLESCEKRKLKRVRISLASDADLEGEMSPEEILEWEEQQ 778
Query: 810 LSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKA 869
L +PV F C ID +PFQLVE+T+LHKTHT+FSLLG+ AYVTS+G+L G++ L+EL+KA
Sbjct: 779 LDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKA 838
Query: 870 IEGH-TKSGVQLRPPLASFRNTTSTRKST 897
IEG T GV++RPPLASFR++ ++ T
Sbjct: 839 IEGSVTAQGVKVRPPLASFRDSATSSSDT 867
>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
Length = 687
Score = 490 bits (1262), Expect = e-138
Identities = 249/560 (44%), Positives = 370/560 (66%), Gaps = 10/560 (1%)
Query: 113 KLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLI 172
+LGEDW FL+ LG+LMALVS++M++ ++A++W Y ++ S L++L W +P+ L+
Sbjct: 45 RLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALV 104
Query: 173 LFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGL--GSGIPVG 230
FS+ F I+P + GSGIPE+KT+L GV+L++YL +K F AKVV L+ L GS + +G
Sbjct: 105 SFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLG 164
Query: 231 KEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSI 290
K GPFVH++ + AA L + + G E +++L AVGV F P GVLFSI
Sbjct: 165 KVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSI 224
Query: 291 EVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPA 350
EV S++F+VR+YWRGFFAAT AF+FR+LAV+N + TIT+L++T+FR+D PFDL E+
Sbjct: 225 EVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFF 284
Query: 351 FAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGM 410
F A+G CG+L +++ R + ++ ++ S+ LA + +Y + T ++AS T+PPG+
Sbjct: 285 FVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGV 344
Query: 411 GQFMAGELMPREAISTLFDNNTWVKHAGD-----PESLGQSAVW---IHPRVNVVIIIFL 462
G F+A L ++ + +LFDN++W + PE L +W HPR + +
Sbjct: 345 GHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAF 404
Query: 463 FFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPG 522
F VMKFWM I+ATT+P+P G FMP+F+LGAA GRL+GE +A+ FP+GI+ + I+PG
Sbjct: 405 FLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPG 464
Query: 523 GYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSII 582
GYA+ GAAA +GAV+HT+STA++ FELTGQI H LP+++AV+ AN +AQS QPS YD I
Sbjct: 465 GYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTI 524
Query: 583 QVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDS 642
VKKLPYLP + + + + VE M + ++ E+ ++ +T V PLV+S
Sbjct: 525 IVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVES 584
Query: 643 KDSMILLGSVERSELQALLQ 662
+S IL+G V+R++L LQ
Sbjct: 585 TESQILVGIVQRAQLVQALQ 604
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/67 (34%), Positives = 34/67 (50%)
Query: 808 EQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQ 867
+Q Q + C + L +TTLH+ LF LL L +VTS G+ G ++ E++
Sbjct: 615 QQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMK 674
Query: 868 KAIEGHT 874
KAI T
Sbjct: 675 KAISNLT 681
>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
Length = 686
Score = 490 bits (1262), Expect = e-138
Identities = 249/560 (44%), Positives = 370/560 (66%), Gaps = 10/560 (1%)
Query: 113 KLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLI 172
+LGEDW FL+ LG+LMALVS++M++ ++A++W Y ++ S L++L W +P+ L+
Sbjct: 45 RLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALV 104
Query: 173 LFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGL--GSGIPVG 230
FS+ F I+P + GSGIPE+KT+L GV+L++YL +K F AKVV L+ L GS + +G
Sbjct: 105 SFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLG 164
Query: 231 KEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSI 290
K GPFVH++ + AA L + + G E +++L AVGV F P GVLFSI
Sbjct: 165 KVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSI 224
Query: 291 EVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPA 350
EV S++F+VR+YWRGFFAAT AF+FR+LAV+N + TIT+L++T+FR+D PFDL E+
Sbjct: 225 EVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFF 284
Query: 351 FAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGM 410
F A+G CG+L +++ R + ++ ++ S+ LA + +Y + T ++AS T+PPG+
Sbjct: 285 FVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGV 344
Query: 411 GQFMAGELMPREAISTLFDNNTWVKHAGD-----PESLGQSAVW---IHPRVNVVIIIFL 462
G F+A L ++ + +LFDN++W + PE L +W HPR + +
Sbjct: 345 GHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAF 404
Query: 463 FFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPG 522
F VMKFWM I+ATT+P+P G FMP+F+LGAA GRL+GE +A+ FP+GI+ + I+PG
Sbjct: 405 FLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPG 464
Query: 523 GYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSII 582
GYA+ GAAA +GAV+HT+STA++ FELTGQI H LP+++AV+ AN +AQS QPS YD I
Sbjct: 465 GYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTI 524
Query: 583 QVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDS 642
VKKLPYLP + + + + VE M + ++ E+ ++ +T V PLV+S
Sbjct: 525 IVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVES 584
Query: 643 KDSMILLGSVERSELQALLQ 662
+S IL+G V+R++L LQ
Sbjct: 585 TESQILVGIVQRAQLVQALQ 604
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/82 (31%), Positives = 37/82 (45%)
Query: 793 LVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVT 852
LV + E Q Q + C + L +TTLH+ LF LL L +VT
Sbjct: 599 LVQALQAEPPSRAPGHQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVT 658
Query: 853 SMGKLRGVLALEELQKAIEGHT 874
S G+ G ++ E++KAI T
Sbjct: 659 SRGRAVGCVSWVEMKKAISNLT 680
>gi|155969705 chloride channel Kb [Homo sapiens]
Length = 687
Score = 481 bits (1239), Expect = e-135
Identities = 251/559 (44%), Positives = 365/559 (65%), Gaps = 11/559 (1%)
Query: 113 KLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLI 172
+LGEDW FL+ LG+LMALVS +MD ++A++W Y ++ S L++L W +P+ L+
Sbjct: 45 RLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALV 104
Query: 173 LFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGL--GSGIPVG 230
FS+ F I+P + GSGIPE+KT+L GVVL++YL +K F AKVV L+ L GS + +G
Sbjct: 105 SFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLG 164
Query: 231 KEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSI 290
K GPFVH++ + AA L + + G E +++L AVGV F P GVLFSI
Sbjct: 165 KVGPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSI 224
Query: 291 EVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPA 350
EV S++F+V +YWRGFFAAT AF+FR+LAV+N + TIT+L++T+FR+D PFDL E+
Sbjct: 225 EVMSSHFSVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFF 284
Query: 351 FAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGM 410
F A+G CG+LG+ +++ R +R ++ S+ LA + +Y + T V+AS T+PP
Sbjct: 285 FVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSA 344
Query: 411 GQFMAGELMPREAISTLFDNNTWVKHAGD-----PESLGQSAVW---IHPRVNVVIIIFL 462
G+F+A L ++ + +LFDN++W + PE L +W HPR + +
Sbjct: 345 GRFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAF 404
Query: 463 FFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPG 522
F VMKFWM I+ATT+P+P G FMP+FV GAA GRL GE ++ +FP+GI+ I I+PG
Sbjct: 405 FLVMKFWMLILATTIPMPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPG 464
Query: 523 GYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSII 582
GYA+ GAAA +GAV+HT+STA++ FE+TGQI H LP+++AV+ AN +AQS QPS YD +
Sbjct: 465 GYALAGAAAFSGAVTHTISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTV 524
Query: 583 QVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDS 642
VKKLPYLP + + + + VE M + ++ E+ ++ +T V PLV+S
Sbjct: 525 IVKKLPYLPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVES 584
Query: 643 KDSMILLGSVERSEL-QAL 660
+S IL+G V R++L QAL
Sbjct: 585 TESQILVGIVRRAQLVQAL 603
Score = 47.8 bits (112), Expect = 5e-05
Identities = 24/67 (35%), Positives = 37/67 (55%)
Query: 808 EQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQ 867
+Q Q + C + +L +T+LH+ H LF LL LH +VTS G+ G ++ E++
Sbjct: 615 QQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTSRGRAVGCVSWVEMK 674
Query: 868 KAIEGHT 874
KAI T
Sbjct: 675 KAISNLT 681
>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 209 bits (532), Expect = 1e-53
Identities = 164/532 (30%), Positives = 256/532 (48%), Gaps = 62/532 (11%)
Query: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218
+ + ++V + L+ + + +P A GSGIPE+KTIL G +++ YL V K +
Sbjct: 208 VNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 267
Query: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278
L + SG+ +GKEGP VH+A C +L + + + ++L+ A GV
Sbjct: 268 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKY---RKNEAKRREVLSAAAAAGVSVA 324
Query: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338
FG P+GGVLFS+E S YF ++ WR FFAA +AF R + + + LF F
Sbjct: 325 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRL---VLFYVEFH 381
Query: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398
P+ L EL F +GI GL GA+F+ R + RK K L K+ ++ +VT
Sbjct: 382 T--PWHLFELVPFILLGIFGGLWGALFI---RTNIAWCRKRKTTQ--LGKYPVIEVLVVT 434
Query: 399 FVIASFTFPPGMGQFMAGELMPREAISTLF--------------DNNTWVKHAGD----P 440
+ A FP + EL IS LF +N G+ P
Sbjct: 435 AITAILAFPNEYTRMSTSEL-----ISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRP 489
Query: 441 ESLG-QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG 499
+G SA+W + L ++K ++I M IP G F+P +GA GRL+G
Sbjct: 490 AGVGVYSAMW---------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
Query: 500 ---EIMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTG 551
E +A + +F+ + I PG YA++GAAA G V+ TVS VI FELTG
Sbjct: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
Query: 552 QIAHILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMV 610
+ +I+P+M A + + VA +L + +YD+ I++ P+L + + T+ ++ +
Sbjct: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--AKEEFAHKTLAMDVMKP 658
Query: 611 RD-----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSEL 657
R S T ++ T++ TT P+V S++S L+G V R +L
Sbjct: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDL 710
Score = 32.3 bits (72), Expect = 2.3
Identities = 16/50 (32%), Positives = 27/50 (54%)
Query: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAI 870
+D SPF + + T + +F LGL VT G+L G++ +++ K I
Sbjct: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
Length = 816
Score = 209 bits (532), Expect = 1e-53
Identities = 164/532 (30%), Positives = 256/532 (48%), Gaps = 62/532 (11%)
Query: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218
+ + ++V + L+ + + +P A GSGIPE+KTIL G +++ YL V K +
Sbjct: 208 VNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 267
Query: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278
L + SG+ +GKEGP VH+A C +L + + + ++L+ A GV
Sbjct: 268 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKY---RKNEAKRREVLSAAAAAGVSVA 324
Query: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338
FG P+GGVLFS+E S YF ++ WR FFAA +AF R + + + LF F
Sbjct: 325 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRL---VLFYVEFH 381
Query: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398
P+ L EL F +GI GL GA+F+ R + RK K L K+ ++ +VT
Sbjct: 382 T--PWHLFELVPFILLGIFGGLWGALFI---RTNIAWCRKRKTTQ--LGKYPVIEVLVVT 434
Query: 399 FVIASFTFPPGMGQFMAGELMPREAISTLF--------------DNNTWVKHAGD----P 440
+ A FP + EL IS LF +N G+ P
Sbjct: 435 AITAILAFPNEYTRMSTSEL-----ISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRP 489
Query: 441 ESLG-QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG 499
+G SA+W + L ++K ++I M IP G F+P +GA GRL+G
Sbjct: 490 AGVGVYSAMW---------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 540
Query: 500 ---EIMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTG 551
E +A + +F+ + I PG YA++GAAA G V+ TVS VI FELTG
Sbjct: 541 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 600
Query: 552 QIAHILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMV 610
+ +I+P+M A + + VA +L + +YD+ I++ P+L + + T+ ++ +
Sbjct: 601 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--AKEEFAHKTLAMDVMKP 658
Query: 611 RD-----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSEL 657
R S T ++ T++ TT P+V S++S L+G V R +L
Sbjct: 659 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDL 710
Score = 32.3 bits (72), Expect = 2.3
Identities = 16/50 (32%), Positives = 27/50 (54%)
Query: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAI 870
+D SPF + + T + +F LGL VT G+L G++ +++ K I
Sbjct: 753 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 802
>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
Length = 746
Score = 209 bits (532), Expect = 1e-53
Identities = 164/532 (30%), Positives = 256/532 (48%), Gaps = 62/532 (11%)
Query: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218
+ + ++V + L+ + + +P A GSGIPE+KTIL G +++ YL V K +
Sbjct: 138 VNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTIT 197
Query: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278
L + SG+ +GKEGP VH+A C +L + + + ++L+ A GV
Sbjct: 198 LVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKY---RKNEAKRREVLSAAAAAGVSVA 254
Query: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338
FG P+GGVLFS+E S YF ++ WR FFAA +AF R + + + LF F
Sbjct: 255 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRL---VLFYVEFH 311
Query: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398
P+ L EL F +GI GL GA+F+ R + RK K L K+ ++ +VT
Sbjct: 312 T--PWHLFELVPFILLGIFGGLWGALFI---RTNIAWCRKRKTTQ--LGKYPVIEVLVVT 364
Query: 399 FVIASFTFPPGMGQFMAGELMPREAISTLF--------------DNNTWVKHAGD----P 440
+ A FP + EL IS LF +N G+ P
Sbjct: 365 AITAILAFPNEYTRMSTSEL-----ISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRP 419
Query: 441 ESLG-QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG 499
+G SA+W + L ++K ++I M IP G F+P +GA GRL+G
Sbjct: 420 AGVGVYSAMW---------QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLG 470
Query: 500 ---EIMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTG 551
E +A + +F+ + I PG YA++GAAA G V+ TVS VI FELTG
Sbjct: 471 VGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG 530
Query: 552 QIAHILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMV 610
+ +I+P+M A + + VA +L + +YD+ I++ P+L + + T+ ++ +
Sbjct: 531 GLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--AKEEFAHKTLAMDVMKP 588
Query: 611 RD-----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSEL 657
R S T ++ T++ TT P+V S++S L+G V R +L
Sbjct: 589 RRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDL 640
Score = 32.3 bits (72), Expect = 2.3
Identities = 16/50 (32%), Positives = 27/50 (54%)
Query: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAI 870
+D SPF + + T + +F LGL VT G+L G++ +++ K I
Sbjct: 683 LDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHI 732
>gi|153252026 chloride channel 4 [Homo sapiens]
Length = 760
Score = 201 bits (512), Expect = 2e-51
Identities = 174/605 (28%), Positives = 277/605 (45%), Gaps = 86/605 (14%)
Query: 118 WIFLVLLGLLMAL--------VSWSMDYVSAKSLQAY----------------------- 146
W+ ++L+GLL V W D L A+
Sbjct: 71 WVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCP 130
Query: 147 ---KWSYAQMQPS-----LPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTIL 198
KWS + S L +L+++ + L+ + + +P A GSGIPE+KTIL
Sbjct: 131 LWQKWSELLVNQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTIL 190
Query: 199 RGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYE 258
G +++ YL + K V L + SG+ +GKEGP VH+A C + F S+F +
Sbjct: 191 SGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCG---NFFSSLFSKYSK 247
Query: 259 QPYYYSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRV 318
++L+ A GV FG P+GGVLFS+E S YF ++ WR FFAA +AF R
Sbjct: 248 NEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRS 307
Query: 319 LAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRK 378
+ + + LF + P+ + EL F +G+ GL G +F+ R + R+
Sbjct: 308 INPFGNSRL---VLFYVEYHT--PWYMAELFPFILLGVFGGLWGTLFI---RCNIAWCRR 359
Query: 379 HKALSQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAGELMPREAISTLF------DNNT 432
K L K+ +L +VT + A +P + EL IS LF +++
Sbjct: 360 RKTTR--LGKYPVLEVIVVTAITAIIAYPNPYTRQSTSEL-----ISELFNDCGALESSQ 412
Query: 433 WVKHAGDPESLGQSAVWIHPRVNVVII------IFLFFVMKFWMSIVATTMPIPCGGFMP 486
+ DP ++ + I R V + + L + K ++I M IP G F+P
Sbjct: 413 LCDYINDP-NMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIP 471
Query: 487 VFVLGAAFGRLVG---EIMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH- 538
+GA GR+VG E +A D I+F + + PG YA++GAAA G V+
Sbjct: 472 SMAVGAIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRM 531
Query: 539 TVSTAVICFELTGQIAHILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQ 597
TVS VI FELTG + +I+P+M A + + VA + + +Y++ I + P+L ++
Sbjct: 532 TVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVK--DE 589
Query: 598 LSKYTIFVEDIMVRDVK-----FVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSV 652
+ T+ + + R + S T ++ TL++ T P+V S+DS L+G
Sbjct: 590 FTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFA 649
Query: 653 ERSEL 657
+R EL
Sbjct: 650 QRREL 654
Score = 30.4 bits (67), Expect = 8.6
Identities = 13/46 (28%), Positives = 25/46 (54%)
Query: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEEL 866
++ SPF + + T + +F LGL VT G+L G++ +++
Sbjct: 697 LNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDV 742
>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
Length = 866
Score = 195 bits (495), Expect = 2e-49
Identities = 155/534 (29%), Positives = 250/534 (46%), Gaps = 55/534 (10%)
Query: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218
+ +++++ + L + + +P A GSGIPE+KTIL G +++ YL + K +
Sbjct: 209 MNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 268
Query: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278
L + SG+ +GKEGP VH+A C + F +F ++L+ A GV
Sbjct: 269 LVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGVSVA 325
Query: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338
FG P+GGVLFS+E S YF ++ WR FFAA +AFV R + + + LF +
Sbjct: 326 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRL---VLFYVEYH 382
Query: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398
P+ L EL F +G+ GL GA F+ R + R+ K S K+ +L IV
Sbjct: 383 T--PWYLFELFPFILLGVFGGLWGAFFI---RANIAWCRRRK--STKFGKYPVLEVIIVA 435
Query: 399 FVIASFTFPPGMGQFMAGELM--------PREAISTL-FDNNTWVKHAGD-----PESLG 444
+ A FP + EL+ P E+ S + N+ D P +G
Sbjct: 436 AITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIG 495
Query: 445 -QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG---E 500
SA+W + L + K M++ + +P G F+P +GA GR+VG E
Sbjct: 496 VYSAIW---------QLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVE 546
Query: 501 IMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTGQIAH 555
+A D +F + I PG YA++GAAA G V+ TVS VI FELTG + +
Sbjct: 547 QLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEY 606
Query: 556 ILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRD-- 612
I+P+M AV+ + V + + +Y++ I++ P+L + +T D+M
Sbjct: 607 IVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA---KEEFTHTTLAADVMRPRRN 663
Query: 613 ----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQ 662
+ T ++ ++ T+ P++ SK+S L+G R +L ++
Sbjct: 664 DPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIE 717
Score = 32.0 bits (71), Expect = 2.9
Identities = 17/63 (26%), Positives = 30/63 (47%)
Query: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIEGHTKSGVQL 880
+D SPF + + T + +F LGL VT G + G++ + + + +E + L
Sbjct: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLEQLKQHVEPL 814
Query: 881 RPP 883
PP
Sbjct: 815 APP 817
>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
Length = 818
Score = 195 bits (495), Expect = 2e-49
Identities = 155/534 (29%), Positives = 250/534 (46%), Gaps = 55/534 (10%)
Query: 159 LQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVA 218
+ +++++ + L + + +P A GSGIPE+KTIL G +++ YL + K +
Sbjct: 209 MNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTIT 268
Query: 219 LTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCC 278
L + SG+ +GKEGP VH+A C + F +F ++L+ A GV
Sbjct: 269 LVLAVASGLSLGKEGPLVHVACCCGNI---FSYLFPKYSTNEAKKREVLSAASAAGVSVA 325
Query: 279 FGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFR 338
FG P+GGVLFS+E S YF ++ WR FFAA +AFV R + + + LF +
Sbjct: 326 FGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRL---VLFYVEYH 382
Query: 339 MDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVT 398
P+ L EL F +G+ GL GA F+ R + R+ K S K+ +L IV
Sbjct: 383 T--PWYLFELFPFILLGVFGGLWGAFFI---RANIAWCRRRK--STKFGKYPVLEVIIVA 435
Query: 399 FVIASFTFPPGMGQFMAGELM--------PREAISTL-FDNNTWVKHAGD-----PESLG 444
+ A FP + EL+ P E+ S + N+ D P +G
Sbjct: 436 AITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGIG 495
Query: 445 -QSAVWIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG---E 500
SA+W + L + K M++ + +P G F+P +GA GR+VG E
Sbjct: 496 VYSAIW---------QLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVE 546
Query: 501 IMAMLFPDGILFDDIIYK----ILPGGYAVIGAAALTGAVSH-TVSTAVICFELTGQIAH 555
+A D +F + I PG YA++GAAA G V+ TVS VI FELTG + +
Sbjct: 547 QLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEY 606
Query: 556 ILPMMVAVILANMVAQSL-QPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVEDIMVRD-- 612
I+P+M AV+ + V + + +Y++ I++ P+L + +T D+M
Sbjct: 607 IVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDA---KEEFTHTTLAADVMRPRRN 663
Query: 613 ----VKFVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQ 662
+ T ++ ++ T+ P++ SK+S L+G R +L ++
Sbjct: 664 DPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIE 717
Score = 32.3 bits (72), Expect = 2.3
Identities = 14/46 (30%), Positives = 25/46 (54%)
Query: 821 IDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEEL 866
+D SPF + + T + +F LGL VT G+L G++ +++
Sbjct: 755 LDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDI 800
>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
Length = 781
Score = 183 bits (464), Expect = 8e-46
Identities = 165/583 (28%), Positives = 270/583 (46%), Gaps = 44/583 (7%)
Query: 118 WIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLV 170
W+ L+G+L LV+ +D V ++L K+ + + L L+W T
Sbjct: 103 WVICALIGILTGLVACFIDIV-VENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAA 161
Query: 171 LILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVG 230
+L ++ I P A GSGIP++K L GV + + +K V KV + + G+ VG
Sbjct: 162 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG 221
Query: 231 KEGPFVHIASICAAVLSKFMSV-------FCGVYEQPYYYSDILTVGCAVGVGCCFGTPL 283
KEGP +H S+ AA +S+ S + + D ++ G A GV FG P+
Sbjct: 222 KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPV 281
Query: 284 GGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFR-VLAVWNKDAVTITALFRTNF-RMD- 340
GGVLFS+E ++++ WR FFA+ S F VL++++ + +++ NF R D
Sbjct: 282 GGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDS 341
Query: 341 --FPFDLKELPAFAAIGICCGLLGAVFVYLHRQV-MLGVRK-HKALSQFL-AKHRLLYPG 395
+ + E+P F A+G+ G+LGAVF L+ + M +R H+ Q + A
Sbjct: 342 EKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA 401
Query: 396 IVTFVI--ASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESLGQSAVWIHPR 453
V FV+ +S P G M+ L A N+ PE S P
Sbjct: 402 TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEY--NSMAAAFFNTPEKSVVSLFHDPPG 459
Query: 454 VNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFD 513
+ + LF ++ F+++ + + G F+P ++GAA+GRL G ++ L I D
Sbjct: 460 SYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD 519
Query: 514 DIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQS 572
PG YA++GAAA L G V T+S VI E T + + P+M+ ++ A +V
Sbjct: 520 -------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDV 572
Query: 573 LQPSLYDSIIQVKKLPYLPDLGWN-QLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQT 631
LYD IQ++ +P+ L W ++ +++ ++M V + G + +L
Sbjct: 573 FIEGLYDMHIQLQSVPF---LHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSD 629
Query: 632 TTV--KTLPLVDSKDS---MILLGSVERSELQALLQRHLCPER 669
T P+V+ D L G + RS+L LL+ + ER
Sbjct: 630 TASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVER 672
>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
Length = 805
Score = 183 bits (464), Expect = 8e-46
Identities = 165/583 (28%), Positives = 270/583 (46%), Gaps = 44/583 (7%)
Query: 118 WIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLV 170
W+ L+G+L LV+ +D V ++L K+ + + L L+W T
Sbjct: 127 WVICALIGILTGLVACFIDIV-VENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAA 185
Query: 171 LILFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVG 230
+L ++ I P A GSGIP++K L GV + + +K V KV + + G+ VG
Sbjct: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVG 245
Query: 231 KEGPFVHIASICAAVLSKFMSV-------FCGVYEQPYYYSDILTVGCAVGVGCCFGTPL 283
KEGP +H S+ AA +S+ S + + D ++ G A GV FG P+
Sbjct: 246 KEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPV 305
Query: 284 GGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFR-VLAVWNKDAVTITALFRTNF-RMD- 340
GGVLFS+E ++++ WR FFA+ S F VL++++ + +++ NF R D
Sbjct: 306 GGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDS 365
Query: 341 --FPFDLKELPAFAAIGICCGLLGAVFVYLHRQV-MLGVRK-HKALSQFL-AKHRLLYPG 395
+ + E+P F A+G+ G+LGAVF L+ + M +R H+ Q + A
Sbjct: 366 EKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLVAAVTA 425
Query: 396 IVTFVI--ASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESLGQSAVWIHPR 453
V FV+ +S P G M+ L A N+ PE S P
Sbjct: 426 TVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEY--NSMAAAFFNTPEKSVVSLFHDPPG 483
Query: 454 VNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFD 513
+ + LF ++ F+++ + + G F+P ++GAA+GRL G ++ L I D
Sbjct: 484 SYNPLTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWAD 543
Query: 514 DIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQS 572
PG YA++GAAA L G V T+S VI E T + + P+M+ ++ A +V
Sbjct: 544 -------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDV 596
Query: 573 LQPSLYDSIIQVKKLPYLPDLGWN-QLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQT 631
LYD IQ++ +P+ L W ++ +++ ++M V + G + +L
Sbjct: 597 FIEGLYDMHIQLQSVPF---LHWEAPVTSHSLTAREVMSTPVTCLRRREKVGVIVDVLSD 653
Query: 632 TTV--KTLPLVDSKDS---MILLGSVERSELQALLQRHLCPER 669
T P+V+ D L G + RS+L LL+ + ER
Sbjct: 654 TASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVER 696
>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
Length = 869
Score = 165 bits (417), Expect = 2e-40
Identities = 205/866 (23%), Positives = 352/866 (40%), Gaps = 116/866 (13%)
Query: 70 SDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMA 129
+ E+D +P+K S D D Y + + + + RR W+ + +G+
Sbjct: 35 TQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDN--KKGRRYEAVKWMVVFAIGVCTG 92
Query: 130 LVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLVLILFSALFCHLI 182
LV +D+ + K+ Q + L L L + F L + ++L LI
Sbjct: 93 LVGLFVDFF-VRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LI 150
Query: 183 SPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASIC 242
P A GSGIPE+K L GV + + ++ + KV+ + + G+ VGKEGP +H S+
Sbjct: 151 EPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVV 210
Query: 243 AAVLSKFMSVFCG--VYEQPYYYS-----DILTVGCAVGVGCCFGTPLGGVLFSIEVTST 295
A L +F S+ + PY+ S D ++ G A GV FG P+GG LFS+E S+
Sbjct: 211 GAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSS 270
Query: 296 YFAVRNYWRGFF---AATFSAFVFRV-LAVWNKDAVTITALFRTNFRMDFPFDLK----- 346
++ W+ F +ATF+ FR + + + + L D K
Sbjct: 271 FWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWT 330
Query: 347 --ELPAFAAIGICCGLLGAVFVYLHRQV----MLGVRKHKALSQFLAKHRLLYPGIVTFV 400
+L F +G+ GLLGA F L++++ M V L + L L +VT V
Sbjct: 331 AMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLES---LLVSLVTTV 387
Query: 401 IASFTFPPGMGQFMAGELMPREAISTLFDNNTWVKHAGDPESL------------GQSAV 448
+ + + GE + S + +++ ++ D S + +
Sbjct: 388 VVF------VASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPNDTYNDMATL 441
Query: 449 WIHPRVNVVIIIF------------LFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGR 496
+ +P+ + ++ +F LFFV+ F ++ + +P G F+P + GAAFGR
Sbjct: 442 FFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFVPSLLCGAAFGR 501
Query: 497 LVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAA-LTGAVSHTVSTAVICFELTGQIAH 555
LV ++ G ++ G +A+IGAAA L G V T+S VI E T +I +
Sbjct: 502 LVANVLKSYIGLGHIYS--------GTFALIGAAAFLGGVVRMTISLTVILIESTNEITY 553
Query: 556 ILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGW-NQLSKYTIFVEDIMVRDVK 614
LP+MV +++A +YD + ++ +P L W ++ + DIM ++
Sbjct: 554 GLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE---WETEVEMDKLRASDIMEPNLT 610
Query: 615 FVSASYTYGELRTLLQTTTVKTLPLVDSKDSMILLGSVERSELQALLQRHLCPERRLRAA 674
+V L ++L+TT P+V ++ +L +
Sbjct: 611 YVYPHTRIQSLVSILRTTVHHAFPVVTENRGN---------------EKEFMKGNQLISN 655
Query: 675 QEMARKLSELPYDGKARLAGEGLPGAPPGR-----PESFAFVDEDEDEDLSGKSELPPSL 729
+K S L G+ R + + P E A + E EDL + L
Sbjct: 656 NIKFKKSSILTRAGEQRKRSQSMKSYPSSELRNMCDEHIASEEPAEKEDLL-QQMLERRY 714
Query: 730 ALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQD 789
+P+ SP E E P I +S L LL R + +
Sbjct: 715 TPYPNLYPDQSPSE-------DWTMEERFRPLTFHGLILRSQLVTLLVRGVCYSESQSSA 767
Query: 790 STDLV-------DNMSPEEIEAWEQEQLSQPVCFD-SCCIDQSPFQLVEQTTLHKTHTLF 841
S + D +I + L+ + D + ++ SPF + T + + LF
Sbjct: 768 SQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLF 827
Query: 842 SLLGL-HLAYVTSMGKLRGVLALEEL 866
+GL HL V ++G++ G++ L
Sbjct: 828 RTMGLRHLPVVNAVGEIVGIITRHNL 853
>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
Length = 353
Score = 103 bits (256), Expect = 1e-21
Identities = 77/265 (29%), Positives = 124/265 (46%), Gaps = 21/265 (7%)
Query: 70 SDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMA 129
+ E+D +P+K S D D Y + + + + RR W+ + +G+
Sbjct: 35 TQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDN--KKGRRYEAVKWMVVFAIGVCTG 92
Query: 130 LVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLVLILFSALFCHLI 182
LV +D+ + K+ Q + L L L + F L + ++L LI
Sbjct: 93 LVGLFVDFF-VRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LI 150
Query: 183 SPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASIC 242
P A GSGIPE+K L GV + + ++ + KV+ + + G+ VGKEGP +H S+
Sbjct: 151 EPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVV 210
Query: 243 AAVLSKFMSVFCG--VYEQPYYYS-----DILTVGCAVGVGCCFGTPLGGVLFSIEVTST 295
A L +F S+ + PY+ S D ++ G A GV FG P+GG LFS+E S+
Sbjct: 211 GAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSS 270
Query: 296 YFAVRNYWRGFF---AATFSAFVFR 317
++ W+ F +ATF+ FR
Sbjct: 271 FWNQGLTWKVLFCSMSATFTLNFFR 295
>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
Length = 308
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/205 (27%), Positives = 93/205 (45%), Gaps = 13/205 (6%)
Query: 70 SDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMA 129
+ E+D +P+K S D D Y + + + + RR W+ + +G+
Sbjct: 35 TQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDN--KKGRRYEAVKWMVVFAIGVCTG 92
Query: 130 LVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLVLILFSALFCHLI 182
LV +D+ + K+ Q + L L L + F L + ++L LI
Sbjct: 93 LVGLFVDFF-VRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LI 150
Query: 183 SPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASIC 242
P A GSGIPE+K L GV + + ++ + KV+ + + G+ VGKEGP +H S+
Sbjct: 151 EPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVV 210
Query: 243 AAVLSKFMSVFCG--VYEQPYYYSD 265
A L +F S+ + PY+ SD
Sbjct: 211 GAGLPQFQSISLRKIQFNFPYFRSD 235
>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
Length = 320
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/205 (27%), Positives = 93/205 (45%), Gaps = 13/205 (6%)
Query: 70 SDREQDIGMPKKTGSSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDWIFLVLLGLLMA 129
+ E+D +P+K S D D Y + + + + RR W+ + +G+
Sbjct: 35 TQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDN--KKGRRYEAVKWMVVFAIGVCTG 92
Query: 130 LVSWSMDYVSAKSLQAYKWSYAQ-------MQPSLPLQFLVWVTFPLVLILFSALFCHLI 182
LV +D+ + K+ Q + L L L + F L + ++L LI
Sbjct: 93 LVGLFVDFF-VRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLV-LI 150
Query: 183 SPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASIC 242
P A GSGIPE+K L GV + + ++ + KV+ + + G+ VGKEGP +H S+
Sbjct: 151 EPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGGLFVGKEGPMIHSGSVV 210
Query: 243 AAVLSKFMSVFCG--VYEQPYYYSD 265
A L +F S+ + PY+ SD
Sbjct: 211 GAGLPQFQSISLRKIQFNFPYFRSD 235
>gi|239757093 PREDICTED: hypothetical protein [Homo sapiens]
Length = 192
Score = 38.5 bits (88), Expect = 0.031
Identities = 31/95 (32%), Positives = 41/95 (43%), Gaps = 15/95 (15%)
Query: 689 KARLAGEGLPGAPPGRPESFAFVDEDEDEDL---SGKSELPPSLALHPSTTAPLSPEEPN 745
+ LAG GLP APPG+ +D L S + +LP L + +T +P P
Sbjct: 23 RGALAGTGLPLAPPGKNRQPIHLDHLRKASLTWASPRVQLPCCLTIAATTESPSPP---- 78
Query: 746 GPLPGHKQQ-------PEAPEPAGQRPSIFQSLLH 773
PLP KQ PE PAG+ + S H
Sbjct: 79 -PLPTEKQSHRVAGSPPEVAGPAGRHRVMPGSCFH 112
>gi|239751599 PREDICTED: hypothetical protein XP_002347926 [Homo
sapiens]
Length = 192
Score = 38.5 bits (88), Expect = 0.031
Identities = 31/95 (32%), Positives = 41/95 (43%), Gaps = 15/95 (15%)
Query: 689 KARLAGEGLPGAPPGRPESFAFVDEDEDEDL---SGKSELPPSLALHPSTTAPLSPEEPN 745
+ LAG GLP APPG+ +D L S + +LP L + +T +P P
Sbjct: 23 RGALAGTGLPLAPPGKNRQPIHLDHLRKASLTWASPRVQLPCCLTIAATTESPSPP---- 78
Query: 746 GPLPGHKQQ-------PEAPEPAGQRPSIFQSLLH 773
PLP KQ PE PAG+ + S H
Sbjct: 79 -PLPTEKQSHRVAGSPPEVAGPAGRHRVMPGSCFH 112
>gi|239746114 PREDICTED: hypothetical protein XP_002344193 [Homo
sapiens]
Length = 192
Score = 38.5 bits (88), Expect = 0.031
Identities = 31/95 (32%), Positives = 41/95 (43%), Gaps = 15/95 (15%)
Query: 689 KARLAGEGLPGAPPGRPESFAFVDEDEDEDL---SGKSELPPSLALHPSTTAPLSPEEPN 745
+ LAG GLP APPG+ +D L S + +LP L + +T +P P
Sbjct: 23 RGALAGTGLPLAPPGKNRQPIHLDHLRKASLTWASPRVQLPCCLTIAATTESPSPP---- 78
Query: 746 GPLPGHKQQ-------PEAPEPAGQRPSIFQSLLH 773
PLP KQ PE PAG+ + S H
Sbjct: 79 -PLPTEKQSHRVAGSPPEVAGPAGRHRVMPGSCFH 112
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 38.1 bits (87), Expect = 0.041
Identities = 35/104 (33%), Positives = 45/104 (43%), Gaps = 19/104 (18%)
Query: 882 PPLASFRNTTSTRKSTGAPPSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLS 941
PP+A T T +PP A+ PE+ P A G P PVP P PP
Sbjct: 809 PPIAP------TGPPTASPPVPAKEE--PEELPAAPGPLPP-PPPPPPPVPGPVTLPPPQ 859
Query: 942 LAPGKVEGELEELELVESPGLEEELADILQGPSLRSTDEEDEDE 985
L P G P LEE+L I ++ S+DEE+E+E
Sbjct: 860 LVPEGTPGG------GGPPALEEDLTVI----NINSSDEEEEEE 893
Score = 31.6 bits (70), Expect = 3.8
Identities = 24/59 (40%), Positives = 28/59 (47%), Gaps = 6/59 (10%)
Query: 911 EDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELEE----LELVESPGLEEE 965
ED T G+V +P P P+ PP S P KV+ E E L VE PG EEE
Sbjct: 961 EDLEFGTAGGEVEEGAPPPPTLPPALPPPES--PPKVQPEPEPEPGLLLEVEEPGTEEE 1017
>gi|122937289 kinesin family member 18B [Homo sapiens]
Length = 855
Score = 37.7 bits (86), Expect = 0.054
Identities = 30/108 (27%), Positives = 47/108 (43%), Gaps = 13/108 (12%)
Query: 879 QLRPPLASFRNTTSTRKSTGAPPSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEP 938
QL+ +A+ R + G PP P+D PG+ +G P +P+P P
Sbjct: 375 QLQAEVAALRKKLQVYEGGGQPP--------PQDLPGSPKSGPPPEHLPSSPLPPHPPSQ 426
Query: 939 PLSLAPGKVEGELEELELVESPGLEEELADILQGPSL-RSTDEEDEDE 985
P + L+E ES G+E ++ ++G S + EDEDE
Sbjct: 427 PCTPELPAGPRALQE----ESLGMEAQVERAMEGNSSDQEQSPEDEDE 470
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 37.0 bits (84), Expect = 0.091
Identities = 28/88 (31%), Positives = 36/88 (40%), Gaps = 13/88 (14%)
Query: 701 PPGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEP 760
PPG P + SG S+ PPSL+ P T +P P + G PG QP AP
Sbjct: 647 PPGHPGG---------QSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPG---QPSAPSQ 694
Query: 761 AGQRPSIFQSLLHCLLGRARPTKKKTTQ 788
P + S L + P + TQ
Sbjct: 695 L-SAPRRYSSSLSPIQAPNHPPPQPPTQ 721
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 37.0 bits (84), Expect = 0.091
Identities = 28/88 (31%), Positives = 36/88 (40%), Gaps = 13/88 (14%)
Query: 701 PPGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEP 760
PPG P + SG S+ PPSL+ P T +P P + G PG QP AP
Sbjct: 569 PPGHPGG---------QSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPG---QPSAPSQ 616
Query: 761 AGQRPSIFQSLLHCLLGRARPTKKKTTQ 788
P + S L + P + TQ
Sbjct: 617 L-SAPRRYSSSLSPIQAPNHPPPQPPTQ 643
>gi|53831995 splicing factor 3a, subunit 1, 120kDa isoform 2 [Homo
sapiens]
Length = 728
Score = 37.0 bits (84), Expect = 0.091
Identities = 59/269 (21%), Positives = 97/269 (36%), Gaps = 51/269 (18%)
Query: 711 VDEDEDEDLSGKSELPPS---------------------LALHPSTTAPLSPEEPNGP-- 747
V+ DE++D K+E PPS + P P+ P P P
Sbjct: 262 VESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQ 321
Query: 748 -LPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIE-AW 805
+ P+A +P P+ + L+ + G P K L+D E+ + +
Sbjct: 322 VIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSI 381
Query: 806 EQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEE 865
++Q V I+ S QL E+ T + G+ T++GK G +++
Sbjct: 382 REKQSDDEVYAPGLDIESSLKQLAERRT--------DIFGVE---ETAIGKKIGEEEIQK 430
Query: 866 LQKAIEGHTKSGVQLRPPLASFRNTT------STRKSTGAPPS---------SAENWNLP 910
++ + SG R A+ N T + K+ G P S N
Sbjct: 431 PEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQ 490
Query: 911 EDRPGATGTGDVIAASPETPVPSPSPEPP 939
+ P ++ T +A P T VP P PP
Sbjct: 491 QPPPPSSATNIPSSAPPITSVPRPPTMPP 519
>gi|5032087 splicing factor 3a, subunit 1, 120kDa isoform 1 [Homo
sapiens]
Length = 793
Score = 37.0 bits (84), Expect = 0.091
Identities = 59/269 (21%), Positives = 97/269 (36%), Gaps = 51/269 (18%)
Query: 711 VDEDEDEDLSGKSELPPS---------------------LALHPSTTAPLSPEEPNGP-- 747
V+ DE++D K+E PPS + P P+ P P P
Sbjct: 327 VESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQ 386
Query: 748 -LPGHKQQPEAPEPAGQRPSIFQSLLHCLLGRARPTKKKTTQDSTDLVDNMSPEEIE-AW 805
+ P+A +P P+ + L+ + G P K L+D E+ + +
Sbjct: 387 VIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQRDRSI 446
Query: 806 EQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEE 865
++Q V I+ S QL E+ T + G+ T++GK G +++
Sbjct: 447 REKQSDDEVYAPGLDIESSLKQLAERRT--------DIFGVE---ETAIGKKIGEEEIQK 495
Query: 866 LQKAIEGHTKSGVQLRPPLASFRNTT------STRKSTGAPPS---------SAENWNLP 910
++ + SG R A+ N T + K+ G P S N
Sbjct: 496 PEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQ 555
Query: 911 EDRPGATGTGDVIAASPETPVPSPSPEPP 939
+ P ++ T +A P T VP P PP
Sbjct: 556 QPPPPSSATNIPSSAPPITSVPRPPTMPP 584
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 37.0 bits (84), Expect = 0.091
Identities = 20/49 (40%), Positives = 24/49 (48%), Gaps = 2/49 (4%)
Query: 715 EDEDLSGKSELPPSLALHPSTTAPLSPE--EPNGPLPGHKQQPEAPEPA 761
E LS SE PS PS P +P+ EP+ P QP AP+PA
Sbjct: 2163 ESPSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQPA 2211
Score = 30.8 bits (68), Expect = 6.6
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 12/55 (21%)
Query: 926 SPETPVPSPSPEPP----LSLAPGKVEGELEELELVESPGLEEELADILQGPSLR 976
+PE P P P PEP SL+P K E+V SPG + +G +LR
Sbjct: 2912 APEPPAPEPPPEPTKVTVQSLSPAK--------EVVSSPGSSPRSSPRPEGTTLR 2958
>gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
Length = 227
Score = 36.6 bits (83), Expect = 0.12
Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 3/77 (3%)
Query: 895 KSTGAPPSSAENWNLPEDR---PGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGEL 951
K+ GA + AE PE PG G+ A+ P+ S P P K EGE
Sbjct: 89 KTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAAPAESAAPAAGEEPSKEEGEP 148
Query: 952 EELELVESPGLEEELAD 968
++ E +P +E +D
Sbjct: 149 KKTEAPAAPAAQETKSD 165
>gi|116268091 PHD finger protein 23 [Homo sapiens]
Length = 403
Score = 36.2 bits (82), Expect = 0.16
Identities = 27/94 (28%), Positives = 39/94 (41%), Gaps = 7/94 (7%)
Query: 668 ERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLSGKSELPP 727
E+R R + RKL + + RL G P APP +S E+E+E+ + E
Sbjct: 210 EKRSRIKKSKKRKLKKA--ERGDRLPPPGPPQAPPSDTDS-----EEEEEEEEEEEEEEM 262
Query: 728 SLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEPA 761
+ + P+ P P P P PE PA
Sbjct: 263 ATVVGGEAPVPVLPTPPEAPRPPATVHPEGVPPA 296
>gi|122937251 lysine (K)-specific demethylase 6B [Homo sapiens]
Length = 1682
Score = 36.2 bits (82), Expect = 0.16
Identities = 26/77 (33%), Positives = 33/77 (42%), Gaps = 14/77 (18%)
Query: 688 GKARLAGEGLPGAPPGRPESFAFVDEDEDEDLSGKSEL-PPSLALHPSTTAPLS-PEEPN 745
G L E + G RP DL G S+ PP+ PS AP + P P+
Sbjct: 1019 GNLDLQSEEIQGREKSRP------------DLGGASKAKPPTAPAPPSAPAPSAQPTPPS 1066
Query: 746 GPLPGHKQQPEAPEPAG 762
+PG K + EAP P G
Sbjct: 1067 ASVPGKKAREEAPGPPG 1083
Score = 35.0 bits (79), Expect = 0.35
Identities = 34/114 (29%), Positives = 51/114 (44%), Gaps = 16/114 (14%)
Query: 857 LRGVLALEELQKAIEGHTKSGVQLRP-PLASFRNTTSTRK-STGAPPSSAENWNLPEDRP 914
L+ + ++ E QK T + V RP PL + + + +T PP+SA +P
Sbjct: 804 LKSLASVLEGQKYCYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSAAPSAQGSPQP 863
Query: 915 GATGTGDVIAA---------SPETPVPSP----SPEPPLSLAPGKVEGE-LEEL 954
A+ + + + E PVP P P PPLSL P + E E LEE+
Sbjct: 864 SASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEI 917
Score = 33.1 bits (74), Expect = 1.3
Identities = 67/272 (24%), Positives = 92/272 (33%), Gaps = 51/272 (18%)
Query: 701 PPGRPESFAFVDEDEDEDLSGKSELPPSLALHPSTTAPLSPEEPNGPLPGHKQQPEAPEP 760
PP P S ++ SG P S P + P +PE GP PG + P P
Sbjct: 607 PPAPPSSC-------HQNTSGSFRRPESP--RPRVSFPKTPEVGPGPPPGPLSKAPQPVP 657
Query: 761 AG------QRPSIFQSLLHCLLGR-ARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQ---- 809
G + P +F L + P + K D + M E I E++Q
Sbjct: 658 PGVGELPARGPRLFDFPPTPLEDQFEEPAEFKILPDGLANIMKMLDESIRKEEEQQQHEA 717
Query: 810 --LSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQ 867
QP + QSPF T T + +A T+ A +E +
Sbjct: 718 GVAPQPPLKEPFASLQSPF---------PTDTAPTTTAPAVAVTTTTTTTTTTTATQEEE 768
Query: 868 KAIEGHTKSGVQLRPPLASFRNTTSTRKSTGAPPSSAENWN-----LPEDRPGATGTGDV 922
K + PPLA F + + PPS A L + GTG
Sbjct: 769 K----KPPPALPPPPPLAKFPPPSQPQPPPPPPPSPASLLKSLASVLEGQKYCYRGTGAA 824
Query: 923 IAASPETPVP----SPSPE------PPLSLAP 944
++ P P+P SP P PP S AP
Sbjct: 825 VSTRP-GPLPTTQYSPGPPSGATALPPTSAAP 855
Score = 31.6 bits (70), Expect = 3.8
Identities = 24/62 (38%), Positives = 28/62 (45%), Gaps = 9/62 (14%)
Query: 925 ASPETPVPSPSPEPPLSLAPGKVEGELEELELVESPGLEEELADILQGPSLRSTDEEDED 984
A P P PS P PP + PGK E E PG+ AD+L+ LRS E
Sbjct: 1051 APPSAPAPSAQPTPPSASVPGKKARE----EAPGPPGVSR--ADMLK---LRSLSEGPPK 1101
Query: 985 EL 986
EL
Sbjct: 1102 EL 1103
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,974,499
Number of Sequences: 37866
Number of extensions: 2235809
Number of successful extensions: 13402
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 12493
Number of HSP's gapped (non-prelim): 1094
length of query: 988
length of database: 18,247,518
effective HSP length: 112
effective length of query: 876
effective length of database: 14,006,526
effective search space: 12269716776
effective search space used: 12269716776
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.