Guide to the Human Genome
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Search of human proteins with 239754540

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239754540 PREDICTED: NAC alpha domain containing [Homo
sapiens]
         (1522 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens]   3006   0.0  
gi|239749105 PREDICTED: NAC alpha domain containing [Homo sapiens]   3004   0.0  
gi|239508792 PREDICTED: NAC alpha domain containing [Homo sapiens]   3004   0.0  
gi|226437579 NAC alpha domain containing [Homo sapiens]              2984   0.0  
gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens]   2984   0.0  
gi|163965366 nascent polypeptide-associated complex alpha subuni...   317   4e-86
gi|163965362 nascent polypeptide-associated complex alpha subuni...   243   8e-64
gi|5031931 nascent polypeptide-associated complex alpha subunit ...   243   8e-64
gi|163965364 nascent polypeptide-associated complex alpha subuni...   243   8e-64
gi|40548328 nascent-polypeptide-associated complex alpha polypep...   222   2e-57
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   107   7e-23
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   100   2e-20
gi|91982772 mucin 17 [Homo sapiens]                                    95   5e-19
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         90   2e-17
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   89   2e-17
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    89   2e-17
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   87   9e-17
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   87   9e-17
gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]        86   4e-16
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             84   1e-15
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e...    83   2e-15
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d...    83   2e-15
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ...    83   2e-15
gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]            82   3e-15
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f...    79   4e-14
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ...    79   4e-14
gi|167736355 mucin 4 isoform a [Homo sapiens]                          77   1e-13
gi|56676397 ankyrin repeat domain 11 [Homo sapiens]                    75   4e-13
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    75   5e-13
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    72   4e-12

>gi|239754540 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1522

 Score = 3006 bits (7793), Expect = 0.0
 Identities = 1522/1522 (100%), Positives = 1522/1522 (100%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS 600

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
            AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
Sbjct: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 840
            AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 840

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL 900
            AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL
Sbjct: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL 900

Query: 901  AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ 960
            AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ
Sbjct: 901  AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ 960

Query: 961  DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020
            DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT
Sbjct: 961  DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020

Query: 1021 GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL 1080
            GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL
Sbjct: 1021 GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL 1080

Query: 1081 SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ 1140
            SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ
Sbjct: 1081 SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ 1140

Query: 1141 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL 1200
            QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL
Sbjct: 1141 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL 1200

Query: 1201 PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS 1260
            PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS
Sbjct: 1201 PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS 1260

Query: 1261 PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP 1320
            PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP
Sbjct: 1261 PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP 1320

Query: 1321 RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA 1380
            RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA
Sbjct: 1321 RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA 1380

Query: 1381 MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA 1440
            MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA
Sbjct: 1381 MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA 1440

Query: 1441 AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA 1500
            AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA
Sbjct: 1441 AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA 1500

Query: 1501 KAVRALRDNHSDIVNAIMELTM 1522
            KAVRALRDNHSDIVNAIMELTM
Sbjct: 1501 KAVRALRDNHSDIVNAIMELTM 1522


>gi|239749105 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1522

 Score = 3004 bits (7787), Expect = 0.0
 Identities = 1520/1522 (99%), Positives = 1522/1522 (100%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQA+EDLTLPQDS
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
            AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
Sbjct: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 840
            AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT+VSQQAEEGLTLPQDS
Sbjct: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL 900
            AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL
Sbjct: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL 900

Query: 901  AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ 960
            AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ
Sbjct: 901  AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ 960

Query: 961  DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020
            DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT
Sbjct: 961  DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020

Query: 1021 GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL 1080
            GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL
Sbjct: 1021 GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL 1080

Query: 1081 SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ 1140
            SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ
Sbjct: 1081 SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ 1140

Query: 1141 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL 1200
            QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL
Sbjct: 1141 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL 1200

Query: 1201 PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS 1260
            PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS
Sbjct: 1201 PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS 1260

Query: 1261 PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP 1320
            PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP
Sbjct: 1261 PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP 1320

Query: 1321 RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA 1380
            RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA
Sbjct: 1321 RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA 1380

Query: 1381 MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA 1440
            MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA
Sbjct: 1381 MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA 1440

Query: 1441 AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA 1500
            AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA
Sbjct: 1441 AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA 1500

Query: 1501 KAVRALRDNHSDIVNAIMELTM 1522
            KAVRALRDNHSDIVNAIMELTM
Sbjct: 1501 KAVRALRDNHSDIVNAIMELTM 1522


>gi|239508792 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1522

 Score = 3004 bits (7787), Expect = 0.0
 Identities = 1520/1522 (99%), Positives = 1522/1522 (100%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQA+EDLTLPQDS
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
            AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
Sbjct: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 840
            AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT+VSQQAEEGLTLPQDS
Sbjct: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL 900
            AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL
Sbjct: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPL 900

Query: 901  AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ 960
            AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ
Sbjct: 901  AVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQ 960

Query: 961  DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020
            DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT
Sbjct: 961  DDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020

Query: 1021 GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL 1080
            GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL
Sbjct: 1021 GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLL 1080

Query: 1081 SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ 1140
            SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ
Sbjct: 1081 SPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ 1140

Query: 1141 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL 1200
            QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL
Sbjct: 1141 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAAL 1200

Query: 1201 PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS 1260
            PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS
Sbjct: 1201 PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLS 1260

Query: 1261 PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP 1320
            PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP
Sbjct: 1261 PHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSP 1320

Query: 1321 RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA 1380
            RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA
Sbjct: 1321 RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKA 1380

Query: 1381 MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA 1440
            MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA
Sbjct: 1381 MSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAA 1440

Query: 1441 AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA 1500
            AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA
Sbjct: 1441 AEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRA 1500

Query: 1501 KAVRALRDNHSDIVNAIMELTM 1522
            KAVRALRDNHSDIVNAIMELTM
Sbjct: 1501 KAVRALRDNHSDIVNAIMELTM 1522


>gi|226437579 NAC alpha domain containing [Homo sapiens]
          Length = 1562

 Score = 2984 bits (7736), Expect = 0.0
 Identities = 1520/1562 (97%), Positives = 1522/1562 (97%), Gaps = 40/1562 (2%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQA+EDLTLPQDS
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
            AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
Sbjct: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 840
            AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT+VSQQAEEGLTLPQDS
Sbjct: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMT----------------- 883
            AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMT                 
Sbjct: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900

Query: 884  -----------------------APLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920
                                   APLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
Sbjct: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960

Query: 921  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 980
            VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
Sbjct: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020

Query: 981  STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1040
            STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
Sbjct: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080

Query: 1041 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1100
            EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
Sbjct: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140

Query: 1101 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1160
            SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
Sbjct: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200

Query: 1161 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1220
            LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
Sbjct: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260

Query: 1221 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1280
            DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
Sbjct: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320

Query: 1281 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1340
            QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
Sbjct: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380

Query: 1341 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1400
            EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
Sbjct: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440

Query: 1401 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1460
            KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
Sbjct: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500

Query: 1461 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1520
            PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
Sbjct: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560

Query: 1521 TM 1522
            TM
Sbjct: 1561 TM 1562


>gi|239743134 PREDICTED: NAC alpha domain containing [Homo sapiens]
          Length = 1562

 Score = 2984 bits (7736), Expect = 0.0
 Identities = 1520/1562 (97%), Positives = 1522/1562 (97%), Gaps = 40/1562 (2%)

Query: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60
            MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK
Sbjct: 1    MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSK 60

Query: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120
            PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV
Sbjct: 61   PGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIV 120

Query: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180
            MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP
Sbjct: 121  MGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTP 180

Query: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240
            TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA
Sbjct: 181  TKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLA 240

Query: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300
            PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL
Sbjct: 241  PAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFL 300

Query: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360
            ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS
Sbjct: 301  ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSAS 360

Query: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420
            FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV
Sbjct: 361  FLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSV 420

Query: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480
            QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST
Sbjct: 421  QKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQEST 480

Query: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540
            ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES
Sbjct: 481  ATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES 540

Query: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS 600
            VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQA+EDLTLPQDS
Sbjct: 541  VTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDS 600

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
            AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV
Sbjct: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS
Sbjct: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780
            AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV
Sbjct: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 780

Query: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 840
            AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT+VSQQAEEGLTLPQDS
Sbjct: 781  AAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 840

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMT----------------- 883
            AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMT                 
Sbjct: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 900

Query: 884  -----------------------APLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920
                                   APLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP
Sbjct: 901  AAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 960

Query: 921  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 980
            VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD
Sbjct: 961  VATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD 1020

Query: 981  STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1040
            STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ
Sbjct: 1021 STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQ 1080

Query: 1041 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1100
            EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP
Sbjct: 1081 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLP 1140

Query: 1101 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1160
            SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV
Sbjct: 1141 SAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1200

Query: 1161 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1220
            LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE
Sbjct: 1201 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1260

Query: 1221 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1280
            DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL
Sbjct: 1261 DEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLAL 1320

Query: 1281 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1340
            QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD
Sbjct: 1321 QILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELD 1380

Query: 1341 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1400
            EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS
Sbjct: 1381 EQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKS 1440

Query: 1401 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1460
            KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR
Sbjct: 1441 KNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPR 1500

Query: 1461 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1520
            PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL
Sbjct: 1501 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMEL 1560

Query: 1521 TM 1522
            TM
Sbjct: 1561 TM 1562


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  317 bits (813), Expect = 4e-86
 Identities = 441/1571 (28%), Positives = 589/1571 (37%), Gaps = 247/1571 (15%)

Query: 82   AWADPGEGGP---SPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTA 138
            ++A P   GP   S ++ P   +  A   E+  PA + P    G  T     SP    T 
Sbjct: 625  SYAGPDSAGPLLKSSLITP---TVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTV 681

Query: 139  LRDQEG-----GHASPDPPPELCSQGDLSVPSPPPDPDSFFT---PPSTPTKTTYALLPA 190
                +      G  +  P     S+     PSP        T    P  P       LP 
Sbjct: 682  SLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPP 741

Query: 191  CGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSG 250
             G     +  +       L    +SP        G S  +S   +L+ LA +     P G
Sbjct: 742  AGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPS---PLG 798

Query: 251  WGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAAL 310
              +SPQ             T  PP+ + S   D+       G+            +P   
Sbjct: 799  VSVSPQ-------------TKRPPTKKGSAGPDTPI-----GNLSSPVSPVEASFLPENS 840

Query: 311  LPFQGSLIFQVEAVEVTPLSPEEEEEEAVADP-DPGGDLAGEGEEDSTSASFLQSLSDLS 369
            L FQGS          TP SP+     +   P  P G      E  + S   L    +  
Sbjct: 841  LSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGP 900

Query: 370  ITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGG 429
             T    +A A     S  SS    A    A      S  P    T             GG
Sbjct: 901  ATPAPKQAPAL----SMTSSSPKKARATPAPKGIPASPSPKGAPT---PPAATPPSPKGG 953

Query: 430  GAKGLQAQDGTVSWAVE--AAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHT 487
             A        +  WA    AA   S +G   +   +             +   AT +P  
Sbjct: 954  PATP------SPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG 1007

Query: 488  LQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEIL----GQESVTA 543
                P +     T  +P+     T    G  +   A P PS +G         G  +  A
Sbjct: 1008 APTPPAV-----TPPSPKGSPAATPFPKGASTPPAATP-PSPKGSPAATPLPKGAPTTPA 1061

Query: 544  EKLPTPQ---EETSLTLCPDSPQNL--KEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQ 598
              LP+P+      SL   P  P       +GG   PS +         P   +  L  P 
Sbjct: 1062 ATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPP 1121

Query: 599  DS------AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTE 652
                    A TPP P       + P P  A T  +         P+  + TPP     T 
Sbjct: 1122 HKGAPTTPAATPPSPKGGL---ATPPPKGAPTTPAATPPS----PKGGLATPPPKGAPTT 1174

Query: 653  LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQ---Q 709
             ++ P P     L +   +   T P   A TPP P       + P P  A T  +     
Sbjct: 1175 PAATP-PSPKGGLATPSPKGAPTTP---AATPPSPKGGL---ATPSPKGAPTTPAATPPS 1227

Query: 710  AEEGLTLPQDS------AMTPPLPLQDTDL---SSAPKPVAAATLVSQQAEEGLTLP--- 757
             + GL  P         A TPP P           AP P AA        + GL  P   
Sbjct: 1228 PKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP---PSLKGGLATPPHK 1284

Query: 758  ---QDSAMTPPLPLQDTDLS---SAPKPVAAATIVSQQAEEGLTLPQDS----AMTPPLP 807
                 + +TPP P      S    AP P  AAT  S +   G   P+ +    A+TPP P
Sbjct: 1285 GAPNPAVVTPPSPKGGPATSPPKGAPTP-PAATPPSPKGSPGTPPPKGAPTPPAVTPPSP 1343

Query: 808  LQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS-------AMTPPLPLQDTDLSS----- 855
             + T    A  P +     +  ++EG T P  +       AMTPP P +   + S     
Sbjct: 1344 -KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDP 1402

Query: 856  --------APKPVAAATPVSQQAEEGLTLPQDSAMT----APLPLQDTGPTSGPEPLAVA 903
                    +PK  A ATPV++   EG   P    +T     P+ L+    TS P+    A
Sbjct: 1403 TSPAVIPLSPKK-APATPVTR---EGAATPSKGDLTPPAVTPVSLKKAPATSAPKG-GPA 1457

Query: 904  TPQ-----TLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKN--------AALPTVP 950
            TP      TL A    +P   P    A ++V  +  P+ AP            A +P+ P
Sbjct: 1458 TPSSKGDPTLPAVTPPSPKEPP----APKQVATSSSPKKAPATPAPMGAPTLPAVIPSSP 1513

Query: 951  EPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGR 1010
            +        + DP     A T     +   +TL  +   +P   +    +   A+  P  
Sbjct: 1514 KEVPATPSSRRDPI----APTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPK- 1568

Query: 1011 EACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAA 1070
                EA A T    +  SP   T    +  +G   P      P       +E P  PPA 
Sbjct: 1569 ----EAPA-TPSSKEASSPPAVT---PSTYKGAPSPKELLIPPAVTSPSPKEAP-TPPAV 1619

Query: 1071 CPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGA-VSSLDRGCPD 1129
             P   +    +PA +     G  T  P  PS++    +  +     +GA V    +G P 
Sbjct: 1620 TPPSPEKGPATPAPK-----GTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPA 1674

Query: 1130 APAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLA-KGQPSTPVDRPLGPD 1188
               PT+               +++    P+   TP++  P     + + S+    P+ PD
Sbjct: 1675 KKGPTA---------------LKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPD 1719

Query: 1189 PSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE-------DEEPPGSLGLPPPQAGVQPAA 1241
            PSA     G    PL   AP      Q+DS +          P G L  PP      P  
Sbjct: 1720 PSAKNGSKG----PLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLA-PPESKASTPLT 1774

Query: 1242 AAVSGTTQPLGTGPRVSLSPHSPLLSP----KVASMDAKDLALQILPPCQVPPPSGPQSP 1297
            AA      P      VS +P  P+  P     V ++  K   L   P   +  PS P +P
Sbjct: 1775 AAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAP 1834

Query: 1298 AG--------------------------PQGLSAPEQQEDEDSLEEDSPRALGSGQHSDS 1331
            A                           P   SA        + +  +    GSG  SDS
Sbjct: 1835 ADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDS 1894

Query: 1332 HGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQG 1391
              ES  EL+EQD     T Q    A A   EE ++KAKQSRSEKKARKAMSKLGLRQ+ G
Sbjct: 1895 D-ESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTG 1953

Query: 1392 VTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPS 1451
            VTR+TI+KSKNILFVI KPDV+KSPASDTY+VFGEAKIEDLSQQ   AAAEKFKV  E  
Sbjct: 1954 VTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAV 2013

Query: 1452 ALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHS 1511
            + + E+   P V      +EE EEEEVDE G+E++DIELVM+QANVSRAKAVRAL++N +
Sbjct: 2014 SNIQENTQTPTV------QEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSN 2067

Query: 1512 DIVNAIMELTM 1522
            DIVNAIMELTM
Sbjct: 2068 DIVNAIMELTM 2078



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 205/872 (23%), Positives = 299/872 (34%), Gaps = 154/872 (17%)

Query: 529  QEGISEILGQESVTAEKLPTPQ-EETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVP 587
            Q G++ +      T   + +PQ ++T+++    SPQN    G L L     P AA ++  
Sbjct: 224  QSGVASLPQTTPTTTLAIASPQVKDTTISSVLISPQN---PGSLSLKGPVSPPAALSL-S 279

Query: 588  RQAEEDLTLPQDSA--MTPP----------LPLQDTDLSS----------APKPVAAATI 625
             Q+   +T  Q +A   TPP           PL  +   S          A       TI
Sbjct: 280  TQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTI 339

Query: 626  VSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP 685
                +  G + P    + PPLP ++  +   P  VAA  +V+   ++G +       +P 
Sbjct: 340  SVDHSSTGASYPSQRSVIPPLPSRNEVV---PATVAAFPVVAPSVDKGPSTISSITCSPS 396

Query: 686  -----------LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 734
                        P     L S+P       LV+Q       +P  S  T PL + +    
Sbjct: 397  GSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQ-------MPVSSVGTTPLVVTN---- 445

Query: 735  SAPKPVAAATLVSQQAEEGLTLPQDSAM------TPPLPLQDTDLSSAPKPVAAATIVSQ 788
              P  +AAA   + +    ++ P  S        T P  L    ++        AT +  
Sbjct: 446  --PCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRI 503

Query: 789  QAEEGLTLPQD-----SAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMT 843
                 L  P+D     S++    P Q  DL + P  +  A     QA  GLT  +D  + 
Sbjct: 504  PVSPPLPDPEDLKNLPSSVLVKFPTQK-DLQTVPASLEGAPFSPAQA--GLTTKKDPTVL 560

Query: 844  PPLPLQDTDL----SSAPKPVAAATPVSQQAEEGLTLPQD-----SAMTAPLPLQDT--- 891
            P +     +     S++  P    +P +  A++ L  P       S+MT+PL +  +   
Sbjct: 561  PLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASV 620

Query: 892  -------GPTS-GP-------EPLAVATPQTLQAEAGCAP----GTEPVATMAQQ--EVG 930
                   GP S GP        P   A P      AG AP    GT    T A    E  
Sbjct: 621  IKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGT 680

Query: 931  EALGPR--PAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEAL 988
             +L P+  P  E     LP VP  +    V        A   T   A E   S   + + 
Sbjct: 681  VSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKS---VPSP 737

Query: 989  SLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLA 1048
            SLP   +  G +  + +S            HT   A   S  KE       ++ G    A
Sbjct: 738  SLPPAGTPPGTKKVDGIS------------HTSALAPVASSPKEC----PTEDSGASATA 781

Query: 1049 QEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVA-TEA 1107
               G  + L       D+P      VS      P +  +G +G  TP   L S V+  EA
Sbjct: 782  SSKGTLTYLA------DSPSPLGVSVSPQTKRPPTK--KGSAGPDTPIGNLSSPVSPVEA 833

Query: 1108 SLDSCPESSVGAVSSLDRGC----PDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGT 1163
            S    PE+S+    S D       P  P+P  APT     P+   G    P E P+    
Sbjct: 834  SF--LPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVV 891

Query: 1164 PLLQPPENLAKGQPSTPVDRP---LGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1220
             L  P E      P+TP  +    L    S+P        P   P +P     P   +  
Sbjct: 892  NLPFPKEG-----PATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAAT 946

Query: 1221 DEEPPGSLGLPPPQ------AGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMD 1274
               P G    P P+      A   P+      T  P G     + +P SP   P   S  
Sbjct: 947  PPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPK 1006

Query: 1275 AKDLALQILPPCQVPPPSGPQSPAGPQGLSAP 1306
                   + PP    P   P +   P+G S P
Sbjct: 1007 GAPTPPAVTPP---SPKGSPAATPFPKGASTP 1035



 Score = 90.9 bits (224), Expect = 9e-18
 Identities = 227/994 (22%), Positives = 338/994 (34%), Gaps = 184/994 (18%)

Query: 474  ALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAM-PQPSQEGI 532
            ++G        P T+  AP    EVAT V+P        +      AA+ M P   +E  
Sbjct: 435  SVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKEPS 494

Query: 533  SEILGQESV-TAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQA- 590
            +++     +  +  LP P++  +L     S   +K     DL +    +  A   P QA 
Sbjct: 495  TQVATTLRIPVSPPLPDPEDLKNL----PSSVLVKFPTQKDLQTVPASLEGAPFSPAQAG 550

Query: 591  ----EEDLTLPQDSAMTPPLPLQDTDLSSAPKPVA-AATIVSQQAEEGLTLPQD-SVMTP 644
                ++   LP   A     P   +  SS   P++  AT+  +   E L + +  S MT 
Sbjct: 551  LTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTS 610

Query: 645  PLPLQD------TELSSAPK---PVAAATLVS--------QQAEEGLTLP-----QDSAM 682
            PL +        T+  + P    P+  ++L++        + A+     P       +  
Sbjct: 611  PLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYT 670

Query: 683  TPPLPLQDTDLSSAPK--PVAAATLVS----QQAEEGLTL---PQDS-AMTPPLPLQDTD 732
            T   P  +  +S APK  PV   TL +      A E   +   PQ++ A    L L    
Sbjct: 671  TTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEI 730

Query: 733  LSSAPKP--VAAATLVSQQAEEGLTLPQDSAMTP------PLPLQD-------------T 771
              S P P    A T    +  +G++    SA+ P        P +D             T
Sbjct: 731  PKSVPSPSLPPAGTPPGTKKVDGIS--HTSALAPVASSPKECPTEDSGASATASSKGTLT 788

Query: 772  DLSSAPKPVAAATI------VSQQAEEGLTLPQDSAMTPPLPLQ---------------- 809
             L+ +P P+  +         +++   G   P  +  +P  P++                
Sbjct: 789  YLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKD 848

Query: 810  ---DTDLSSAPKPVAAAT--LVSQQAEEGLTLPQDSAMTP-----PLPLQDTDLSSAPKP 859
                T   + P P  A T   V+  + +G+TLP     TP     P P ++   + APK 
Sbjct: 849  SPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFP-KEGPATPAPKQ 907

Query: 860  VAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAP--- 916
              A +  S   ++    P    + A        P   P P A   P      A  +P   
Sbjct: 908  APALSMTSSSPKKARATPAPKGIPA-----SPSPKGAPTPPAATPPSPKGGPATPSPKWA 962

Query: 917  GTEPVATMAQQEVGEAL-GPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAA 975
             T P AT    + G A   P+ AP    A   T P P            P   A TP + 
Sbjct: 963  PTPPAATPPSPKGGPATPSPKGAPTPPAA---TPPSPKGGPATPSPKGAPTPPAVTPPSP 1019

Query: 976  QEDADSTLGMEALSLPEPAS---------------GAGEEIAEALSRP-GREACLEAR-A 1018
            +    +T   +  S P  A+               GA    A  L  P G  A    + A
Sbjct: 1020 KGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGA 1079

Query: 1019 HTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG-----GAREVPDAPP----- 1068
             T   A P SP K      + +   + P A    P+  L      GA   P A P     
Sbjct: 1080 PTPPAATPPSP-KGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKG 1138

Query: 1069 -AACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGC 1127
              A P    A     A       G +TP P    A  T A+    P+   G  +   +G 
Sbjct: 1139 GLATPPPKGAPTTPAATPPSPKGGLATPPP--KGAPTTPAATPPSPKG--GLATPSPKGA 1194

Query: 1128 PDAPAPT-----------------SAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPE 1170
            P  PA T                 + P +  P P  GL +   P   P+   TP   PP 
Sbjct: 1195 PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGL-ATPSPKGAPT---TPAATPPS 1250

Query: 1171 NLAKGQPSTPVDR--PLGPDPSAPGTLAGAALPPLE-PPAPCLCQDPQEDSVEDEEPPGS 1227
               KG P+TP  +  P  P  + P    G A PP +  P P +   P         PP  
Sbjct: 1251 --PKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPP-- 1306

Query: 1228 LGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQ 1287
             G P P A   P+     GT  P G     +++P SP  +P           L    P  
Sbjct: 1307 KGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTP----------TLPATTPSS 1356

Query: 1288 VPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPR 1321
               P+ P S  GP   +A    +   ++   SP+
Sbjct: 1357 KGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPK 1390



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 209/1020 (20%), Positives = 346/1020 (33%), Gaps = 145/1020 (14%)

Query: 13   PEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASW 72
            P + + GP T     A     +     +   A TP P   +     + P  +  P     
Sbjct: 993  PPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPL 1052

Query: 73   DAGPGGAPSAWADPGEGGPSPMLL-------------PEGLSSQALSTEAPL-PATLEPR 118
              G    P+A     +GGP+   L             P+G  +      AP+ PA   P 
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPS 1112

Query: 119  IVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVP--SPPPDPDSFFTP 176
               G  T     +P          +GG A+P P      +G  + P  +PP       TP
Sbjct: 1113 PKGGLATPPHKGAPTTPAATPPSPKGGLATPPP------KGAPTTPAATPPSPKGGLATP 1166

Query: 177  PSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSL 236
            P     TT A  P     G A  S          +PP SP G   T       ++P+ + 
Sbjct: 1167 PPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP-SPKGGLATPSPKGAPTTPAATP 1225

Query: 237  SLLAPAEGLDFPSGWGL---------SPQGSMVDERELHPAGTPEPPSSESSLSADSSSS 287
               +P  GL  PS  G          SP+G         P G P PP++         ++
Sbjct: 1226 P--SPKGGLATPSPKGAPTTPAATPPSPKGGPATP---PPKGAPTPPAATPPSLKGGLAT 1280

Query: 288  WGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGG- 346
               +G        A +P +     P  G      +     P +     + +   P P G 
Sbjct: 1281 PPHKG--------APNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGA 1332

Query: 347  ---------DLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYA 397
                        G     +T+ S     +  S  EG     A        +    S    
Sbjct: 1333 PTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRG 1392

Query: 398  EADDERLYSGEPHAQATL-----LQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTS 452
             A       G+P + A +        +   T E +   +KG          +++ AP TS
Sbjct: 1393 PAIPSP--KGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATS 1450

Query: 453  -DRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEET 511
              +G   +   +            G  +   VTP + +  P  + +VAT  +P+     T
Sbjct: 1451 APKGGPATPSSK------------GDPTLPAVTPPSPKEPPAPK-QVATSSSPKKA-PAT 1496

Query: 512  DSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGL 571
             +  G  +    +P   +E  +    +    A       ++T  TL   +P+       +
Sbjct: 1497 PAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATL---APKEALIPPAM 1553

Query: 572  DLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 631
             +PS +K  A  T            P+++  TP      +  +S+P  V  +T     + 
Sbjct: 1554 TVPSPKKTPAIPT------------PKEAPATP-----SSKEASSPPAVTPSTYKGAPSP 1596

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 691
            + L +P    +T P P        AP P A   +     E+G   P         P+  +
Sbjct: 1597 KELLIP--PAVTSPSP------KEAPTPPA---VTPPSPEKGPATPAPKGTPTSPPVTPS 1645

Query: 692  DLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSAPKPVAAATLVS 747
             L  +P   A+ T      + G T+PQ S   P    P  L++  ++ AP+   +  +++
Sbjct: 1646 SLKDSPTSPASVT-----CKMGATVPQASKGLPAKKGPTALKEVLVAPAPE---STPIIT 1697

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKP---VAAATIVSQQAEEGLTLP-QDSAMT 803
                +G    + SA +PP+    +  + +  P   VA A ++  Q +   T   +D++ +
Sbjct: 1698 APTRKGPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHS 1757

Query: 804  PPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 863
            P  PL       AP    A+T ++  A E +    +SA     P     L  AP PV   
Sbjct: 1758 PKGPL-------APPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTL 1810

Query: 864  TPVSQ--QAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLA-----------VATPQTLQA 910
             P  Q   +  GL L   S   AP    +  P   PEP++           + TP++   
Sbjct: 1811 PPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGI 1870

Query: 911  EAGCAPGTEPVATMAQQEVGEALGPRPAPE-EKNAALPTVPEPAALDQVQQDDPQPAAEA 969
                    +PV    +    E+      PE E+  +     + A L    + D +P ++A
Sbjct: 1871 PVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKA 1930



 Score = 70.9 bits (172), Expect = 9e-12
 Identities = 221/1029 (21%), Positives = 337/1029 (32%), Gaps = 244/1029 (23%)

Query: 478  ESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQ------------------ES 519
            E+T TV P T Q  P  Q E A  V P +      +  GQ                   +
Sbjct: 4    EATETV-PATEQELPQPQAETA--VLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSA 60

Query: 520  AAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTL----CPDSPQNLKEEGGLDL-- 573
            A  A P PS   I+        T  ++P PQ  +   L     P++P  L    G  +  
Sbjct: 61   ANQASPFPSPSTIAS-------TPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISP 113

Query: 574  -----------------PSGRKPVAAATIVPRQAEEDLTLPQDSAMTPP----------- 605
                             PS   P+A   + P   ++    P +   +PP           
Sbjct: 114  AALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVI 173

Query: 606  ---LPL----QDTDLSSAPKPVA-----------------------AATIVSQQAEEGLT 635
                P+      T+L+  P  V                         A+I S  A    T
Sbjct: 174  TLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQT 233

Query: 636  LPQDSVMTPPLPLQDTELSS--------------APKPVAAATLVSQQAEEGLTLPQDSA 681
             P  ++      ++DT +SS               P    AA  +S Q+   +T  Q +A
Sbjct: 234  TPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTA 293

Query: 682  --MTPP----------LPLQDTDLS----------SAPKPVAAATLVSQQAEEGLTLPQD 719
               TPP           PL  +             SA       T+    +  G + P  
Sbjct: 294  GPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQ 353

Query: 720  SAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP-----------LPL 768
             ++ PPLP ++      P  VAA  +V+   ++G +       +P             P 
Sbjct: 354  RSVIPPLPSRN---EVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSPT 410

Query: 769  QDTDLSSAPKPVAAATIVSQQAEEG-------LTLPQDSAMTPPLPLQ-----DTDLSSA 816
                L S+P       +V+Q            +T P   A  P    +        +SS 
Sbjct: 411  TSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSG 470

Query: 817  P----KPVAAATLV---------SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 863
            P    +P + A LV         S Q    L +P    ++PPLP    DL + P  V   
Sbjct: 471  PISNIEPTSPAALVMAPVAPKEPSTQVATTLRIP----VSPPLP-DPEDLKNLPSSVLVK 525

Query: 864  TPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPE----PLAVATPQTLQAEAGCAPGTE 919
             P  +  +   T+P  S   AP      G T+  +    PL  A P+   +    +   E
Sbjct: 526  FPTQKDLQ---TVPA-SLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPE 581

Query: 920  ----PVATMAQQEVGEALGPRPAPEEKNAALPTVPEPA-ALDQVQQDDPQPAAEAGTPWA 974
                P AT+A++ +GE     P P  K A+  T P    +   V + D     ++  P  
Sbjct: 582  IPLSPEATLAKKSLGE-----PLPIGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLL 636

Query: 975  AQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETL 1034
                   T+    L   +PA  A        +  G        +   +G    +P+   +
Sbjct: 637  KSSLITPTVAAFPLESADPAGVA------PTTAKGTSTYTTTASPFLEGTVSLAPKNHPV 690

Query: 1035 EVENQQEGGLKPLAQEH-----------GPRSALGGAREVPDAPPAACPEVSQARLLSPA 1083
            +        L P A E+            P + L  A E+P + P+  P +  A      
Sbjct: 691  KEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPS--PSLPPAGTPPGT 748

Query: 1084 REERGLSGKS--TPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAP---TSAPT 1138
            ++  G+S  S   P  + P    TE S  S   SS G ++ L     D+P+P   + +P 
Sbjct: 749  KKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYL----ADSPSPLGVSVSPQ 804

Query: 1139 SQQPEPVLGLGSVEQPHEVPSVLGTPLLQP--PENLAKGQPS----------TPVDRPLG 1186
            +++P    G    + P    S   +P+     PEN    Q S          TP      
Sbjct: 805  TKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGA 864

Query: 1187 PDPSA--PGTLAGAALPPLEPPAPCLC------QDPQEDSVEDEEPPGSLGLPPPQAGVQ 1238
            P PSA  P +  G  LPP E P P +       + P   + +           P +A   
Sbjct: 865  PTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARAT 924

Query: 1239 PAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPP-PSGPQSP 1297
            PA   +  +  P G     + +P SP   P   S           PP   PP P G  + 
Sbjct: 925  PAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAP-----TPPAATPPSPKGGPAT 979

Query: 1298 AGPQGLSAP 1306
              P+G   P
Sbjct: 980  PSPKGAPTP 988



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 68/283 (24%), Positives = 93/283 (32%), Gaps = 42/283 (14%)

Query: 18   PGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPG 77
            P P+   +  AA   +  GG         P P  +        P A P P+GAS      
Sbjct: 980  PSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGAS------ 1033

Query: 78   GAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAART 137
              P+A     +G P+   LP+G  +         PA   P    G  T     +P     
Sbjct: 1034 TPPAATPPSPKGSPAATPLPKGAPT--------TPAATLPSPKGGPATPSLKGAPTPPAA 1085

Query: 138  ALRDQEGGHASPDP-----PPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACG 192
                 +GG A+P P     PP           +PP       TPP     TT A  P   
Sbjct: 1086 TPPSPKGGPATPSPKGAPMPP---------AATPPSPKGGLATPPHKGAPTTPAATPP-S 1135

Query: 193  PHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWG 252
            P G       +       + P SP G   T       ++P+ +    +P  GL  PS  G
Sbjct: 1136 PKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP--SPKGGLATPSPKG 1193

Query: 253  L---------SPQGSMVDERELHPAGTP--EPPSSESSLSADS 284
                      SP+G +          TP   PPS +  L+  S
Sbjct: 1194 APTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPS 1236



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 61/240 (25%), Positives = 83/240 (34%), Gaps = 42/240 (17%)

Query: 46   TPGPSH---LALTFL-PSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLS 101
            TP P     L++T   P K  A P P+G      P GAP+    P    PSP   P   S
Sbjct: 902  TPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPT---PPAATPPSPKGGPATPS 958

Query: 102  SQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDP-----PPELC 156
             +   T    PA   P    G  T     +P          +GG A+P P     PP + 
Sbjct: 959  PKWAPTP---PAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVT 1015

Query: 157  SQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASP 216
                   P+  P P    TPP+  T  +    PA  P              L    P +P
Sbjct: 1016 PPSPKGSPAATPFPKGASTPPAA-TPPSPKGSPAATP--------------LPKGAPTTP 1060

Query: 217  SGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSS 276
            + +  +  G    ++PS   +   PA     P G   +P           P G P PP++
Sbjct: 1061 AATLPSPKGG--PATPSLKGAPTPPAATPPSPKGGPATPS----------PKGAPMPPAA 1108


>gi|163965362 nascent polypeptide-associated complex alpha subunit
            isoform b [Homo sapiens]
          Length = 215

 Score =  243 bits (621), Expect = 8e-64
 Identities = 139/219 (63%), Positives = 162/219 (73%), Gaps = 10/219 (4%)

Query: 1307 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1363
            E  E   + E++ P+     GSG  SDS  ES  EL+EQD     T Q    A A   EE
Sbjct: 4    EATETVPATEQELPQPQAETGSGTESDSD-ESVPELEEQDSTQATTQQAQLAAAAEIDEE 62

Query: 1364 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1423
             ++KAKQSRSEKKARKAMSKLGLRQ+ GVTR+TI+KSKNILFVI KPDV+KSPASDTY+V
Sbjct: 63   PVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIV 122

Query: 1424 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1483
            FGEAKIEDLSQQ   AAAEKFKV  E  + + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1484 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1522
            E++DIELVM+QANVSRAKAVRAL++N +DIVNAIMELTM
Sbjct: 177  EVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215


>gi|5031931 nascent polypeptide-associated complex alpha subunit
            isoform b [Homo sapiens]
          Length = 215

 Score =  243 bits (621), Expect = 8e-64
 Identities = 139/219 (63%), Positives = 162/219 (73%), Gaps = 10/219 (4%)

Query: 1307 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1363
            E  E   + E++ P+     GSG  SDS  ES  EL+EQD     T Q    A A   EE
Sbjct: 4    EATETVPATEQELPQPQAETGSGTESDSD-ESVPELEEQDSTQATTQQAQLAAAAEIDEE 62

Query: 1364 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1423
             ++KAKQSRSEKKARKAMSKLGLRQ+ GVTR+TI+KSKNILFVI KPDV+KSPASDTY+V
Sbjct: 63   PVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIV 122

Query: 1424 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1483
            FGEAKIEDLSQQ   AAAEKFKV  E  + + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1484 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1522
            E++DIELVM+QANVSRAKAVRAL++N +DIVNAIMELTM
Sbjct: 177  EVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215


>gi|163965364 nascent polypeptide-associated complex alpha subunit
            isoform b [Homo sapiens]
          Length = 215

 Score =  243 bits (621), Expect = 8e-64
 Identities = 139/219 (63%), Positives = 162/219 (73%), Gaps = 10/219 (4%)

Query: 1307 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1363
            E  E   + E++ P+     GSG  SDS  ES  EL+EQD     T Q    A A   EE
Sbjct: 4    EATETVPATEQELPQPQAETGSGTESDSD-ESVPELEEQDSTQATTQQAQLAAAAEIDEE 62

Query: 1364 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1423
             ++KAKQSRSEKKARKAMSKLGLRQ+ GVTR+TI+KSKNILFVI KPDV+KSPASDTY+V
Sbjct: 63   PVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIV 122

Query: 1424 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1483
            FGEAKIEDLSQQ   AAAEKFKV  E  + + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1484 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1522
            E++DIELVM+QANVSRAKAVRAL++N +DIVNAIMELTM
Sbjct: 177  EVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 215


>gi|40548328 nascent-polypeptide-associated complex alpha
            polypeptide-like [Homo sapiens]
          Length = 215

 Score =  222 bits (566), Expect = 2e-57
 Identities = 128/219 (58%), Positives = 157/219 (71%), Gaps = 10/219 (4%)

Query: 1307 EQQEDEDSLEEDSPRA---LGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1363
            E  E   + E++ P++    GSG  SDS GES   ++EQD     T +    A A   EE
Sbjct: 4    EATETVPATEQELPQSQAETGSGTASDS-GESVPGIEEQDSTQTTTQKAWLVAAAEIDEE 62

Query: 1364 TIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVV 1423
             + KAKQSRSEK+ARKAMSKLGL Q+ GVTR+TI KSKNILFVI K DV+KSPASD Y+V
Sbjct: 63   PVGKAKQSRSEKRARKAMSKLGLLQVTGVTRVTIWKSKNILFVITKLDVYKSPASDAYIV 122

Query: 1424 FGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1483
            FGEAKI+DLSQQ   AAAEKF+V  E    + E+   P V      +EE EEEEVDE G+
Sbjct: 123  FGEAKIQDLSQQAQLAAAEKFRVQGEAVGNIQENTQTPTV------QEESEEEEVDETGV 176

Query: 1484 ELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM 1522
            E++D++LVM+QANVSRAKAVRAL++N +DIVNAIMELT+
Sbjct: 177  EVKDVKLVMSQANVSRAKAVRALKNNSNDIVNAIMELTV 215


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score =  107 bits (268), Expect = 7e-23
 Identities = 200/823 (24%), Positives = 297/823 (36%), Gaps = 127/823 (15%)

Query: 597  PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSA 656
            P+   +T   P +   L    KP+  A +   Q E  L  P +  M    P +++ LS  
Sbjct: 396  PKGGHVTSMQPKEPGPLQCEAKPLGKAGV---QLEPQLEAPLNEEMPLLPPPEESPLSPP 452

Query: 657  PK-----PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK-----PVAAATLV 706
            P+     P   A+ +S   EE    P   A+    PL+++ LS  P+     P   ++  
Sbjct: 453  PEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPF 512

Query: 707  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL 766
            S   E  L+ P++S   PP P  +T LS  P+    A+ +S   EE       S ++PP 
Sbjct: 513  SPLEESPLSPPEES---PPSPALETPLSPPPE----ASPLSPPFEE-------SPLSPP- 557

Query: 767  PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPL-------PLQDTDLSSAPK- 818
                 +L ++P P A+      +       P++S M+PP        P +++ LS  P+ 
Sbjct: 558  ---PEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEE 614

Query: 819  ----PVAAATLVSQQAEEGLTLP--QDSAMTPPLP---LQDTDLSSAPKPVAAATPVSQQ 869
                P   A+ +S   E+    P  ++S M+PP     L    + S   P    +P+S  
Sbjct: 615  SPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPP 674

Query: 870  AEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQ--Q 927
             EE  T P   A     P +D+ PTS P   + A+P    +         P+  + +  Q
Sbjct: 675  PEESPTSPPPEASRLSPPPEDS-PTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQ 733

Query: 928  EVGEALGPR--PAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGM 985
                + GP   P PEE + + P   EP    Q ++    P  E     A  E+   +   
Sbjct: 734  LCPRSEGPHLSPRPEEPHLS-PRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQA 792

Query: 986  EALSL---PEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQ-QE 1041
            E   L   PE    + +     LS    E CL             SPQ E   +  Q +E
Sbjct: 793  EGPHLSPQPEELHLSPQTEEPHLSPVPEEPCL-------------SPQPEESHLSPQSEE 839

Query: 1042 GGLKPLAQEHG-----PRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPE 1096
              L P  +E        +  L    E P   P  CP   +  L  P  E         P 
Sbjct: 840  PCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPA 899

Query: 1097 PTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAP---TSQQPEPVLGLGSVEQ 1153
             + P         +  P S  G  S   +  P  P P       T+  P  +  LG +E 
Sbjct: 900  LSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEY 959

Query: 1154 PH--------EVP---SVLGTPLLQPPE-NLAKGQPSTPVDRPLGPDPSAPGTLAGAALP 1201
            P         E P    +L TP+  PPE N    +P  P+  P      +PG+  G A P
Sbjct: 960  PFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILP-----PSPGSPVGPASP 1014

Query: 1202 PLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSP 1261
             L  P P  C    + S+  +  P S   PP          +V     P+  G  V +S 
Sbjct: 1015 ILMEPLPPQCSPLLQHSLVPQNSPPSQCSPP------ALPLSVPSPLSPI--GKVVGVSD 1066

Query: 1262 HSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQG-LSAPEQQEDEDSLEEDSP 1320
             + L   +   +          P C    PS       P G LS P            +P
Sbjct: 1067 EAELHEMETEKVSE--------PECPALEPSATSPLPSPMGDLSCP------------AP 1106

Query: 1321 RALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEE 1363
                +       GE +A LD  D  AP +   P Q P   + E
Sbjct: 1107 SPAPALDDFSGLGEDTAPLDGID--APGSQPEPGQTPGSLASE 1147



 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 212/900 (23%), Positives = 312/900 (34%), Gaps = 140/900 (15%)

Query: 503  TPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSP 562
            +P +  EE+  +   E+     P+ S           S   E+LPT     +  L P   
Sbjct: 518  SPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPE 577

Query: 563  QNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 622
            ++       + P    P A+    P +       P++S ++PP    +    S P     
Sbjct: 578  ESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPP---PEASRLSPP----- 629

Query: 623  ATIVSQQAEEGLTLPQDSVMTPP---LPLQDTELSSAPKPVAAATLVSQQAEEG-LTLPQ 678
                          P+DS M+PP    P+      S   P+   + +S   EE  L+ P 
Sbjct: 630  --------------PEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPP 675

Query: 679  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 738
            + + T P P + + LS  P P  + T    +       P+DS M+  LPL+++ L   P+
Sbjct: 676  EESPTSP-PPEASRLS--PPPEDSPTSPPPEDSPASPPPEDSLMS--LPLEESPLLPLPE 730

Query: 739  -----PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATI-----VSQ 788
                 P +    +S + EE    P+          ++  LS  P+      +     +S 
Sbjct: 731  EPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSP 790

Query: 789  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ-DSAMTPPLP 847
            QAE     PQ   +      ++  LS    PV     +S Q EE    PQ +     P P
Sbjct: 791  QAEGPHLSPQPEELHLSPQTEEPHLS----PVPEEPCLSPQPEESHLSPQSEEPCLSPRP 846

Query: 848  LQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQT 907
             +++ LS    P     P+S + E+    P        LPL        P P   +    
Sbjct: 847  -EESHLS----PELEKPPLSPRPEKPPEEPGQCPAPEELPL-------FPPPGEPSLSPL 894

Query: 908  LQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVP--EPAALDQVQQDDPQP 965
            L   A   PG  P++              P PEE    LP  P  EP+   Q+   DP P
Sbjct: 895  LGEPALSEPGEPPLS--------------PLPEE----LPLSPSGEPSLSPQLMPPDPLP 936

Query: 966  AAEAGTPWAAQEDADSTLG-----MEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020
               +    AA   A S LG       A    +P S     I E    P  EA        
Sbjct: 937  PPLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPV 996

Query: 1021 GDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPR--SALGGAREVP-DAPPAACP----E 1073
                 P SP            G   P+  E  P   S L     VP ++PP+ C      
Sbjct: 997  PPMILPPSP--------GSPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALP 1048

Query: 1074 VSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSL-----DRGCP 1128
            +S    LSP  +  G+S     E  L      + S   CP     A S L     D  CP
Sbjct: 1049 LSVPSPLSPIGKVVGVS----DEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCP 1104

Query: 1129 -DAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGP 1187
              +PAP     S   E    L  ++ P   P        Q P +LA     +PV   L P
Sbjct: 1105 APSPAPALDDFSGLGEDTAPLDGIDAPGSQPEP-----GQTPGSLASELKGSPV--LLDP 1157

Query: 1188 DPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGT 1247
            +  AP T       P+E    C     Q    E++E P +   P P   ++   + +   
Sbjct: 1158 EELAPVT-------PMEVYPECKQTAGQGSPCEEQEEPRAPVAPTPPTLIK---SDIVNE 1207

Query: 1248 TQPLGTGPRVSLSPHS-PLL-SPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQG--- 1302
               L  G   +  P S PLL SP      +  + L +         S   SPA  +G   
Sbjct: 1208 ISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGV---------STDVSPARDEGSLR 1258

Query: 1303 LSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPA-QAPAGGS 1361
            L      E +DSL  D+  A+  G+     G   +      I   ++   P  + P GG+
Sbjct: 1259 LCTDSLPETDDSLLCDAGTAISGGKAEGEKGRRRSSPARSRIKQGRSSSFPGRRRPRGGA 1318



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 141/522 (27%), Positives = 179/522 (34%), Gaps = 110/522 (21%)

Query: 877  PQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQ-------EV 929
            P  S  + P P  DT PT  P+ L VA     Q + G     +P      Q       + 
Sbjct: 367  PVCSRFSPPEP-GDT-PTDEPDALYVACQG--QPKGGHVTSMQPKEPGPLQCEAKPLGKA 422

Query: 930  GEALGPR-PAPEEKNAALPTVPEPAALDQVQQDDP-QPAAEAGTPWAAQEDADSTLGMEA 987
            G  L P+  AP  +   L   PE + L    ++ P  P  EA       E+  ++   EA
Sbjct: 423  GVQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEA 482

Query: 988  LSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPL 1047
            L L  P   +       LS P  E+             P SP  E+      +E  L P 
Sbjct: 483  LHLSRPLEES------PLSPPPEES-------------PLSPPPESSPFSPLEESPLSP- 522

Query: 1048 AQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEA 1107
             +E  P  AL    E P +PP   PE S    LSP  EE  LS    P   LP++   EA
Sbjct: 523  PEESPPSPAL----ETPLSPP---PEASP---LSPPFEESPLS---PPPEELPTSPPPEA 569

Query: 1108 S-LDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLL 1166
            S L   PE S           P +P P  +P S  PE        E+    P    +PL 
Sbjct: 570  SRLSPPPEES-----------PMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLS 618

Query: 1167 QPPENLAKGQPSTPVDRPLGPDPS-------------APGTLAGAALPPLE--------- 1204
             PPE      P  P D P+ P P              +P  +     PP E         
Sbjct: 619  PPPEASRLSPP--PEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPE 676

Query: 1205 ------PPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQ--------P 1250
                  PP       P EDS     P  S   PPP+  +       S            P
Sbjct: 677  ESPTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCP 736

Query: 1251 LGTGPRVSLSPHSPLLSPKV----ASMDAKDLALQILP--PCQVPPPSGPQ-SP--AGPQ 1301
               GP +S  P  P LSP+      S  A++  L   P  PC    P  P  SP   GP 
Sbjct: 737  RSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPH 796

Query: 1302 GLSAPEQ-----QEDEDSLEEDSPRALGSGQHSDSHGESSAE 1338
                PE+     Q +E  L         S Q  +SH    +E
Sbjct: 797  LSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSE 838



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 165/741 (22%), Positives = 253/741 (34%), Gaps = 113/741 (15%)

Query: 556  TLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEED-------LTLPQDSAMTPPLPL 608
            +L PDS   L +E  L L   R  +A      +Q ++        + + Q     P +  
Sbjct: 3708 SLGPDS--RLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLGQVAIQQQQQQGPGV-- 3763

Query: 609  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQ 668
              T+ +  PKP     ++   + +GL + Q S    P P Q  +    P  VA    V Q
Sbjct: 3764 -QTNQALGPKPQG---LMPPSSHQGLLVQQLS----PQPPQGPQGMLGPAQVA----VLQ 3811

Query: 669  QAEEGLTLPQDS----AMTPPLPLQDTDLSSAPKPVAAATLVS-QQAEEGLTLPQDSAMT 723
            Q   G   PQ       MT    L    L+   + +    LV+ QQ ++     Q  +M 
Sbjct: 3812 QQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGSMA 3871

Query: 724  PPLPLQDTDLSSAPKPVAAATLVS--QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 781
                LQ + +S + +P  +A  +   QQ ++   L Q       L  Q        + + 
Sbjct: 3872 GLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQ----LQQQQQQQLQQQQQLQ 3927

Query: 782  AATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSA 841
               +  QQ ++ L   Q       L  Q   L    +         QQ ++   L Q   
Sbjct: 3928 QQQLQQQQQQQQLQQQQQQQ----LQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQSRT 3983

Query: 842  MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQ----DSAMTAPLPLQDTGPTSGP 897
            +  P   Q   ++  P     A P+   +  G   P             P   +  T GP
Sbjct: 3984 LLSPQQQQQQQVALGPG--MPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGP 4041

Query: 898  E-----PLAVAT-PQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPE 951
                  PLA+ T P+++  E G     E   +++       + P+P P+  +  L     
Sbjct: 4042 STHQGGPLAIGTTPESMATEPG-----EVKPSLSGDSQLLLVQPQPQPQPSSLQLQP--- 4093

Query: 952  PAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLP----EPASGAGEE---IAEA 1004
            P  L   QQ        AG     Q  + S+   EA S+P    +P+   G++   + + 
Sbjct: 4094 PLRLPGQQQQQVSLLHTAGGGSHGQLGSGSS--SEASSVPHLLAQPSVSLGDQPGSMTQN 4151

Query: 1005 LSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVP 1064
            L  P ++  LE       G +P  P       +     G+ P   +   R+ L G     
Sbjct: 4152 LLGP-QQPMLERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQL--RAQLQGVLAKN 4208

Query: 1065 DAPPAACPEVSQA--RLLSPAREERGLSGKSTP---EP-----TLPSAVATEASLDSCPE 1114
                   P+  Q    LL   + ++  + + TP   EP      L   +  +  L   P 
Sbjct: 4209 PQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPG 4268

Query: 1115 SSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAK 1174
               G +  L  G    P P   P    P   L  G V  P     V  TP    P+    
Sbjct: 4269 PQTGPLQELGAG----PRPQGPPRLPAPPGALSTGPVLGP-----VHPTPPPSSPQ---- 4315

Query: 1175 GQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQ 1234
             +P  P   P  P    P     A LPP  P  P     PQ  ++E           PP 
Sbjct: 4316 -EPKRPSQLP-SPSSQLP---TEAQLPPTHPGTP----KPQGPTLE-----------PPP 4355

Query: 1235 AGVQPAAAAVSGTTQPLGTGP 1255
              V PAAA ++ T    G GP
Sbjct: 4356 GRVSPAAAQLADTLFSKGLGP 4376



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 131/590 (22%), Positives = 191/590 (32%), Gaps = 70/590 (11%)

Query: 606  LPLQDTDLSSAPKPVAAATIV--SQQAEEGLTLPQDSVMTPPL-----PLQDTELSSAPK 658
            +P Q   L S P P AA TI   S     GL+   D  + PP      P    EL     
Sbjct: 2106 IPPQPGALGSPP-PAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPGELFLKLP 2164

Query: 659  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT---LVSQQAEEGLT 715
            P   A + SQ   +   L     + P  P         P P  A     ++   +  G  
Sbjct: 2165 PQVPAQVPSQ---DPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAG 2221

Query: 716  LPQDSAMTPP-------------LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAM 762
             P +   TPP             L  +   L +   P +      + +E  L+ P     
Sbjct: 2222 QPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGES 2281

Query: 763  TPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 822
               L ++  +L ++        +    +      P        L L+  D+  AP    A
Sbjct: 2282 RKALEVKKEELGASSPSYGPPNLGFVDS------PSSGTHLGGLELKTPDVFKAPLTPRA 2335

Query: 823  ATLVSQQAEEGLTL--PQDSAMTPPLPLQDTDL-------SSAPKPVAAATPVSQQAEEG 873
            + +  Q    GL    P  +    P P    D+           +P     P     E  
Sbjct: 2336 SQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESC 2395

Query: 874  LTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEAL 933
              LP  S  + P       P S     +  TP+ L AEA C     PV    Q     + 
Sbjct: 2396 CALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFC---PSPVTPRFQSPDPYSR 2452

Query: 934  GP-RPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPE 992
             P RP   +  A L   P P          P+ A +AG+       A ++LG        
Sbjct: 2453 PPSRPQSRDPFAPLHKPPRP--------QPPEVAFKAGSL------AHTSLGAGGFPAAL 2498

Query: 993  PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHG 1052
            PA  AGE  A+  S  G+         TG      SP + T   +   E  LKP   + G
Sbjct: 2499 PAGPAGELHAKVPS--GQPPNFVRSPGTGAFVGTPSPMRFTFP-QAVGEPSLKPPVPQPG 2555

Query: 1053 PRSALGGAREVPDAPPAACPEVSQARLLS----PAREERGLSGKSTPEPTLPSAVATEAS 1108
                 G        P    P+ +   + +    P+    G S  ST E    S +   + 
Sbjct: 2556 LPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGLSPLRPPSV 2615

Query: 1109 LDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVP 1158
            L   P +  G++  L  G       TS P  ++ +P  G+GS     E+P
Sbjct: 2616 LP--PPAPDGSLPYLSHGASQRSGITS-PVEKREDPGTGMGSSLATAELP 2662



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 192/874 (21%), Positives = 301/874 (34%), Gaps = 149/874 (17%)

Query: 574  PSGRKPVAAATIVPRQAEEDLTLPQ-----DSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 628
            P  R P AA    PR A     LP+     +     P P Q T  +   +P  AA  +  
Sbjct: 3096 PEERPPPAADASEPRLAS---VLPEVKPKVEEGGRHPSPCQFTIATPKVEPAPAANSLGL 3152

Query: 629  QAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 688
              + G ++         +  +DT + + P   +  T  +++A  G T    + +  P PL
Sbjct: 3153 GLKPGQSM---------MGSRDTRMGTGPFSSSGHT--AEKASFGATGGPPAHLLTPSPL 3201

Query: 689  QDTDLSSAPKPVAAATLVSQQAEEG-LTLPQDSAMT-PPLPLQDTDLSSAPKPVAAATLV 746
                      P  ++ L   + E G LTLP   A +   L   ++ L ++  P+    L+
Sbjct: 3202 SG--------PGGSSLLEKFELESGALTLPGGPAASGDELDKMESSLVASELPLLIEDLL 3253

Query: 747  SQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAATIVSQQA-------EEGL 794
              + +E     Q SA   P   Q        L SAP P  A ++  + +       ++ L
Sbjct: 3254 EHEKKELQKKQQLSAQLQPAQQQQQQQQQHSLLSAPGPAQAMSLPHEGSSPSLAGSQQQL 3313

Query: 795  TLPQDSAMTP--PLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLP-QDSAMTPPLPLQDT 851
            +L    A  P  P PL  T   +       A  ++  + +G  L  Q       +P Q +
Sbjct: 3314 SLGLAGARQPGLPQPLMPTQPPAHALQQRLAPSMAMVSNQGHMLSGQHGGQAGLVPQQSS 3373

Query: 852  DLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPE---PLAVATPQTL 908
                + KP+    P      + L + Q  A +   P  D    +  +   P+A A    L
Sbjct: 3374 QPVLSQKPMGTMPPSMCMKPQQLAMQQQLANSF-FPDTDLDKFAAEDIIDPIAKAKMVAL 3432

Query: 909  --------QAEAGCAPGT--EPVATMAQQEVGEALGPRP---------APEEKNAALPTV 949
                    Q   G APG   + V+ +AQ+  G   GP           + +E++A  P+ 
Sbjct: 3433 KGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSG---GPSSDLQNHVAAGSGQERSAGDPSQ 3489

Query: 950  PEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPG 1009
            P P         +P   A+     A Q   +  L      L        E+I   + R  
Sbjct: 3490 PRP---------NPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIG--VHRKS 3538

Query: 1010 REA-CLEARAHTGDGAKPDSPQKETLEVENQQEGGL-KPLAQ------EHGPRSA--LGG 1059
            R+A C + R     G +      E L++  +Q+  + K L Q      EH    A     
Sbjct: 3539 RKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNK 3598

Query: 1060 AREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGA 1119
             ++          + S    LSP++  R L+        LP  +     L   P+   G 
Sbjct: 3599 QQQQQQQQQQQQQQHSAVLALSPSQSPRLLT-------KLPGQLLPGHGLQP-PQGPPGG 3650

Query: 1120 VSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPST 1179
             +   R  P   A    P      P L     +Q  +  S     L  P      G  + 
Sbjct: 3651 QAGGLRLTPGGMALPGQPGG----PFLNTALAQQQQQQHSGGAGSLAGPSGGFFPGNLAL 3706

Query: 1180 PVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQP 1239
               R LGPD      L       L+     L Q  Q+   + ++    LG    Q  +Q 
Sbjct: 3707 ---RSLGPD----SRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQHLLG----QVAIQQ 3755

Query: 1240 AAAAVSG--TTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSP 1297
                  G  T Q LG  P+  + P S            + L +Q L P    PP GPQ  
Sbjct: 3756 QQQQGPGVQTNQALGPKPQGLMPPSSH-----------QGLLVQQLSP---QPPQGPQGM 3801

Query: 1298 AGPQGLSAPEQQEDEDSLEEDSPRALG-SGQHSDSHGESSAELDEQDILAPQTVQCPAQA 1356
             GP  ++  +QQ          P ALG  G H       S  L    +         AQ 
Sbjct: 3802 LGPAQVAVLQQQH---------PGALGPQGPHRQVLMTQSRVLSSPQL---------AQQ 3843

Query: 1357 PAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQ 1390
              G     +  A+Q + +++ ++  S  GL  +Q
Sbjct: 3844 GQGLMGHRLVTAQQQQQQQQHQQQGSMAGLSHLQ 3877



 Score = 45.1 bits (105), Expect = 5e-04
 Identities = 78/294 (26%), Positives = 107/294 (36%), Gaps = 46/294 (15%)

Query: 45   LTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLS--- 101
            L+P P    L  +P +P   PQ EG          P     P E   SP      LS   
Sbjct: 770  LSPQPEEPCLCAVPEEPHLSPQAEG----------PHLSPQPEELHLSPQTEEPHLSPVP 819

Query: 102  SQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQ-EGGHASPDP--PPELCSQ 158
             +   +  P  + L P+    EE C   LSPR   + L  + E    SP P  PPE   Q
Sbjct: 820  EEPCLSPQPEESHLSPQ---SEEPC---LSPRPEESHLSPELEKPPLSPRPEKPPEEPGQ 873

Query: 159  GDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSG 218
                   P P+    F PP  P+ +     PA    G+   S   L +EL  SP   PS 
Sbjct: 874  ------CPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLS--PLPEELPLSPSGEPSL 925

Query: 219  SYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSES 278
            S      D      S  ++  AP           LSP G +  E      G  +P S  +
Sbjct: 926  SPQLMPPDPLPPPLSPIITAAAPP---------ALSPLGEL--EYPFGAKGDSDPESPLA 974

Query: 279  SLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPE 332
            +   ++  S   E +  D      +P+ P  L P  GS +     + + PL P+
Sbjct: 975  APILETPISPPPEANCTD-----PEPVPPMILPPSPGSPVGPASPILMEPLPPQ 1023



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 137/604 (22%), Positives = 196/604 (32%), Gaps = 56/604 (9%)

Query: 727  PLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 786
            P   T+ +  PKP     L+   + +GL + Q S    P P Q       P  VA    V
Sbjct: 3761 PGVQTNQALGPKPQG---LMPPSSHQGLLVQQLS----PQPPQGPQGMLGPAQVA----V 3809

Query: 787  SQQAEEGLTLPQDS----AMTPPLPLQDTDLSSAPKPVAAATLVS-QQAEEGLTLPQDSA 841
             QQ   G   PQ       MT    L    L+   + +    LV+ QQ ++     Q  +
Sbjct: 3810 LQQQHPGALGPQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQQGS 3869

Query: 842  MTPPLPLQDTDLSSAPKPVAAATPVSQ----QAEEGLTLPQDSAMTAPLPLQDTGPTSGP 897
            M     LQ + +S + +P  +A P+      Q ++ L   Q         LQ        
Sbjct: 3870 MAGLSHLQQSLMSHSGQPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQLQQQQQLQQQ 3929

Query: 898  EPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQ 957
            +       Q LQ +       +      QQ+  +    +   +++   L        L  
Sbjct: 3930 QLQQQQQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQ--SRTLLSP 3987

Query: 958  VQQDDPQPAAEAGTPWAAQEDADS--TLGMEALSLPEPASGAGEEIAEALSRPGREACLE 1015
             QQ   Q A   G P    +   S   LG   L         G+E          EA   
Sbjct: 3988 QQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLL-------TGKEQNTVDPAVSSEATEG 4040

Query: 1016 ARAHTGD----GAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDA--PPA 1069
               H G     G  P+S   E  EV+    G  + L  +  P+      +  P    P  
Sbjct: 4041 PSTHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQ 4100

Query: 1070 ACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEA-SLDSCPESSVGAVSSLDRGCP 1128
               +VS           +  SG S+   ++P  +A  + SL   P S    +    +   
Sbjct: 4101 QQQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPML 4160

Query: 1129 DAPAPTSA-PTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGP 1187
            + P   +  P   +P PVL  G       +   +G    Q    LAK     P  R L P
Sbjct: 4161 ERPMQNNTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKN----PQLRHLSP 4216

Query: 1188 DPSAPGTLAGAALPPLEPPAPCLCQDP--QEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1245
                   L    +      +  + Q P  QE   +     G LG  P   G        +
Sbjct: 4217 QQQQQ--LQALLMQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFP---GPQT 4271

Query: 1246 GTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSA 1305
            G  Q LG GPR    P  P      A   A      + P    PPPS PQ P  P  L +
Sbjct: 4272 GPLQELGAGPRPQGPPRLP------APPGALSTGPVLGPVHPTPPPSSPQEPKRPSQLPS 4325

Query: 1306 PEQQ 1309
            P  Q
Sbjct: 4326 PSSQ 4329



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 120/517 (23%), Positives = 163/517 (31%), Gaps = 129/517 (24%)

Query: 806  LPLQDTDLSSAPKPVAAATLV--SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 863
            +P Q   L S P P AA T+   S     GL+   D  + PP         S P P    
Sbjct: 2106 IPPQPGALGSPP-PAAAPTIFIGSPTTPAGLSTSADGFLKPPA-------GSVPGP---- 2153

Query: 864  TPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVAT 923
                   E  L LP    + A +P QD        P  +A    L+     AP T P   
Sbjct: 2154 ---DSPGELFLKLPPQ--VPAQVPSQD--------PFGLAPAYPLEPRFPTAPPTYP--- 2197

Query: 924  MAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTL 983
                       P P+P    A  P +   +     Q  +       GTP       D  L
Sbjct: 2198 -----------PYPSPTGAPAQPPMLGASSRPGAGQPGEFH-TTPPGTPRHQPSTPDPFL 2245

Query: 984  -----GMEALSLPE-PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVE 1037
                  ++ L++PE P  G G+     LS P                 P    ++ LEV+
Sbjct: 2246 KPRCPSLDNLAVPESPGVGGGKASEPLLSPP-----------------PFGESRKALEVK 2288

Query: 1038 NQQEGGLKP------LAQEHGPRSA--LGGAR-EVPDAPPAAC-PEVSQARLLSPAREER 1087
             ++ G   P      L     P S   LGG   + PD   A   P  SQ    SP     
Sbjct: 2289 KEELGASSPSYGPPNLGFVDSPSSGTHLGGLELKTPDVFKAPLTPRASQVEPQSP----- 2343

Query: 1088 GLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLG 1147
            GL G    EP    A+A                          P+P S P   +P     
Sbjct: 2344 GL-GLRPQEPPPAQALA--------------------------PSPPSHPDIFRP----- 2371

Query: 1148 LGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALP--PLEP 1205
             GS   P+  P +   P   PPE+     P +    P    P++P + + +  P  P   
Sbjct: 2372 -GSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPL 2430

Query: 1206 PAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPL 1265
             A   C  P     +  +P      PP +   +   A       PL   PR    P  P 
Sbjct: 2431 SAEAFCPSPVTPRFQSPDP---YSRPPSRPQSRDPFA-------PLHKPPR----PQPPE 2476

Query: 1266 LSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQG 1302
            ++ K  S+    L     P      P+G      P G
Sbjct: 2477 VAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSG 2513



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 87/375 (23%), Positives = 133/375 (35%), Gaps = 54/375 (14%)

Query: 891  TGPTSGPEPLAVATPQTLQAEA--GCAP----GTEPVATMAQQEVGEALGPRPAPEEKN- 943
            + P + P  L    P ++Q +   G  P    G  P    + ++   AL  R   E K+ 
Sbjct: 4617 SNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASARDSERAL--RDTSEVKSL 4674

Query: 944  ---AALPTVPEPAALD-QVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGE 999
               AALPT P     D +++ D+   + ++  P ++ E   S LG EA   P   SG  E
Sbjct: 4675 DLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPE---SILGEEAPRFPHLGSGRWE 4731

Query: 1000 EIAEALS-----------------RPGREACLEARA-------HTGDGAKPDSPQKETLE 1035
            +   ALS                 +P     LE            G G++       +  
Sbjct: 4732 QEDRALSPVIPLIPRASIPVFPDTKPYGALGLEVPGKLPVTTWEKGKGSEVSVMLTVSAA 4791

Query: 1036 VENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP 1095
                  G +  +A+    +         P++P  A  E  +     P  +E+GL GKS P
Sbjct: 4792 AAKNLNGVMVAVAELLSMKIPNSYEVLFPESPARAGTEPKKGEAEGPGGKEKGLEGKS-P 4850

Query: 1096 EPTLPSAVATEASLDSCP-ESSVGAVSSLDRGCPDAPAPT----SAPTSQQPEPVLGLGS 1150
            +         +A L     +S +  +S L +  P    PT    +   S      L    
Sbjct: 4851 DTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPP 4910

Query: 1151 VEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCL 1210
             E+P   PS L      PP       P+ P+      +P  P  L  A+ P    P P  
Sbjct: 4911 PEEPSPPPSPLAPSPASPPTEPLVELPTEPL-----AEPPVPSPLPLASSPESARPKP-R 4964

Query: 1211 CQDPQEDSVEDEEPP 1225
             + P+E   ED  PP
Sbjct: 4965 ARPPEEG--EDSRPP 4977



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 164/746 (21%), Positives = 240/746 (32%), Gaps = 114/746 (15%)

Query: 560  DSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKP 619
            DSP +    GGL+L +    V  A + PR ++ +   PQ    +P L L+  +      P
Sbjct: 2308 DSPSSGTHLGGLELKT--PDVFKAPLTPRASQVE---PQ----SPGLGLRPQE-----PP 2353

Query: 620  VAAATIVSQQAEEGLTLP---QDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTL 676
             A A   S  +   +  P    D    PPL    T     P P +   L  +      +L
Sbjct: 2354 PAQALAPSPPSHPDIFRPGSYTDPYAQPPL----TPRPQPPPPESCCALPPR------SL 2403

Query: 677  PQDSAMTPPLPLQDTDLSSAP---KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 733
            P D     P   Q    S +P   +P++A              P   +  P  P      
Sbjct: 2404 PSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPF 2463

Query: 734  SSA-----PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL---SSAP----KPVA 781
            +       P+P   A      A   L      A  P  P  +      S  P    +   
Sbjct: 2464 APLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPG 2523

Query: 782  AATIVSQQAEEGLTLPQ---DSAMTPPLPL------QDTDLSSAPKP-VAAATLVSQQAE 831
                V   +    T PQ   + ++ PP+P          +    P P +      +    
Sbjct: 2524 TGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVA 2583

Query: 832  EGLTLPQDSAMTPPL----------PLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSA 881
             G   P  S + P            PL+   +   P P  +   +S  A       Q S 
Sbjct: 2584 TGNFHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGAS------QRSG 2637

Query: 882  MTAPLPLQDTGPTSGPEPLAVAT-PQTLQAEAGCAPGTEPVATMAQQEVGEAL------- 933
            +T+P+  ++   T     LA A  P T          TE      +Q + E L       
Sbjct: 2638 ITSPVEKREDPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQR 2697

Query: 934  -GPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAE----AGTPWAAQEDADSTLGMEAL 988
               R   E   AA   V  P +      +   PA E      TP+A  +D  S +G+   
Sbjct: 2698 NTLRQEKETAAAAAGAVGPPGSWGA---EPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPS 2754

Query: 989  SLPEPASGAGE-EIAEALSRPGREAC-----LEARAHTGDGAK--PDSPQKETLEVENQQ 1040
             L  P  G G     + LSRP   A      + +R   G        +P   +L ++ QQ
Sbjct: 2755 KLSGPILGPGSFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQ 2814

Query: 1041 EGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSP-AREERGLSGKSTPEPTL 1099
            +   +              +   P  P    PE+ +  L SP A     L G   P P  
Sbjct: 2815 QQLWQQQQATAATSMRFAMSARFPSTPG---PELGRQALGSPLAGISTRLPGPGEPVPG- 2870

Query: 1100 PSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQ-----PEPVLGLGSVEQP 1154
            P+  A    L    +  +G   +   G      P   P S+      PE + GL     P
Sbjct: 2871 PAGPAQFIELRHNVQKGLGPGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLP 2930

Query: 1155 HEVPSVLGTPLLQ---PPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLC 1211
             + PS    P L     P    KG P+ P    L   P +  T  G   P         C
Sbjct: 2931 PQKPSAPPAPELNNSLHPTPHTKG-PTLPTGLELVNRPPS-STELGRPNPLALEAGKLPC 2988

Query: 1212 QDPQED-------SVEDEEPPGSLGL 1230
            +DP+ D       ++ED+E    LGL
Sbjct: 2989 EDPELDDDFDAHKALEDDEELAHLGL 3014



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 159/773 (20%), Positives = 239/773 (30%), Gaps = 152/773 (19%)

Query: 686  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL 745
            L L+  D+  AP    A+ +  Q    GL  PQ+    PP         S P      + 
Sbjct: 2319 LELKTPDVFKAPLTPRASQVEPQSPGLGLR-PQEP---PPAQALAPSPPSHPDIFRPGSY 2374

Query: 746  VSQQAEEGLTL------PQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQD 799
                A+  LT       P+     PP  L     S  P     A+  SQ + +    P+ 
Sbjct: 2375 TDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVP-----ASPQSQSSSQSPLTPRP 2429

Query: 800  SAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL------PLQDTDL 853
             +     P   T    +P P +      Q  +    L +     PP        L  T L
Sbjct: 2430 LSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSL 2489

Query: 854  SSAPKPVAAATPVSQQAEEGLTLPQDSA------------MTAPLPLQDTGPTSGPEPL- 900
             +   P  AA P     E    +P                +  P P++ T P +  EP  
Sbjct: 2490 GAGGFP--AALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSL 2547

Query: 901  -------AVATPQTLQAEAGCAPG-------TEPVATMAQQEVGEALGPRPAPEEKNAAL 946
                    +  P  + +  G  P           VAT      G  LGP      ++  L
Sbjct: 2548 KPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPLGPSSGSTGESYGL 2607

Query: 947  PTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDAD-STLGMEALSLPEPASGAGEEIAEAL 1005
              +  P+ L       P PA +   P+ +   +  S +        +P +G G  +A A 
Sbjct: 2608 SPLRPPSVL-------PPPAPDGSLPYLSHGASQRSGITSPVEKREDPGTGMGSSLATAE 2660

Query: 1006 SRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPD 1065
                ++  +   + T    +    ++   E+  +Q+     L QE    +A  GA   P 
Sbjct: 2661 LPGTQDPGMSGLSQTE--LEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPG 2718

Query: 1066 A------------------PPAACPEVSQARLLSPAREERGLSGK----STPEPTLPSAV 1103
            +                  P A   + S    L P++    + G     S    + P   
Sbjct: 2719 SWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPP 2778

Query: 1104 ATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPV-----------------L 1146
            AT +S+D      VG   +  +    AP P S P  QQ + +                  
Sbjct: 2779 ATPSSMDVNSRQLVGGSQAFYQR---APYPGSLPLQQQQQQLWQQQQATAATSMRFAMSA 2835

Query: 1147 GLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDP------------SAPGT 1194
               S   P      LG+PL      L    P  PV  P GP                 GT
Sbjct: 2836 RFPSTPGPELGRQALGSPLAGISTRLPG--PGEPVPGPAGPAQFIELRHNVQKGLGPGGT 2893

Query: 1195 LAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPA---------AAAVS 1245
                  PP  P    + +DP   + E        GLPP +    PA              
Sbjct: 2894 PFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTK 2953

Query: 1246 GTTQPLGTGPRVSLSPHSPLLS-PKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLS 1304
            G T P G    V+  P S  L  P   +++A  L      PC        + P       
Sbjct: 2954 GPTLPTGL-ELVNRPPSSTELGRPNPLALEAGKL------PC--------EDPELDDDFD 2998

Query: 1305 APEQQEDEDSLE-----------EDSPRALGSGQHSDSHGESSAELDEQDILA 1346
            A +  ED++ L            +D    L + + +D H +     DE D+LA
Sbjct: 2999 AHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLA 3051



 Score = 35.0 bits (79), Expect = 0.55
 Identities = 36/128 (28%), Positives = 51/128 (39%), Gaps = 18/128 (14%)

Query: 132  PRAARTALRDQEGGHASPDPPP---ELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALL 188
            P   ++ LR   G  A P  P    +L ++ +LS P  PP       PPS   K    + 
Sbjct: 4584 PVNGQSQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVT 4643

Query: 189  PA--CGPH----GDARDSEAELRD-------ELLDSPPASPSGSY--ITADGDSWASSPS 233
            P+   G H      ARDSE  LRD       +LL + P  P      +  + D  + SP 
Sbjct: 4644 PSEELGEHPKDAASARDSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPD 4703

Query: 234  CSLSLLAP 241
              +   +P
Sbjct: 4704 SIVPASSP 4711



 Score = 34.7 bits (78), Expect = 0.72
 Identities = 46/174 (26%), Positives = 63/174 (36%), Gaps = 16/174 (9%)

Query: 112  PATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPD 171
            P    P I +G  T  A LS  +A   L+   G    PD P EL  +    VP+  P  D
Sbjct: 2117 PPAAAPTIFIGSPTTPAGLST-SADGFLKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQD 2175

Query: 172  SFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDS---PPASPSGSYITADGDSW 228
             F   P+ P +  +   P   P   +  + A  +  +L +   P A   G + T    + 
Sbjct: 2176 PFGLAPAYPLEPRFPTAPPTYPPYPS-PTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTP 2234

Query: 229  ASSPSCSLSLLAP----AEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSES 278
               PS     L P     + L  P   G+   G    E  L P     PP  ES
Sbjct: 2235 RHQPSTPDPFLKPRCPSLDNLAVPESPGVG--GGKASEPLLSP-----PPFGES 2281



 Score = 32.3 bits (72), Expect = 3.6
 Identities = 69/269 (25%), Positives = 96/269 (35%), Gaps = 57/269 (21%)

Query: 44   ALTPGPSHLALTFLP-------SKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPML- 95
            AL P P      F P       ++P   P+P+       P    S  A P    PS    
Sbjct: 2357 ALAPSPPSHPDIFRPGSYTDPYAQPPLTPRPQ-------PPPPESCCALPPRSLPSDPFS 2409

Query: 96   -LPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDP--- 151
             +P    SQ+ S+++PL     PR +  E  C + ++PR              SPDP   
Sbjct: 2410 RVPASPQSQS-SSQSPLT----PRPLSAEAFCPSPVTPR------------FQSPDPYSR 2452

Query: 152  PPELCSQGD----LSVPSPPPDPDSFFTPPSTP-TKTTYALLPACGPHGDARDSEAELRD 206
            PP      D    L  P  P  P+  F   S   T       PA  P G A +  A++  
Sbjct: 2453 PPSRPQSRDPFAPLHKPPRPQPPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPS 2512

Query: 207  ELLDSPPASP-SGSYITADGDSWASSPSC----SLSLLAPAEGLDFPSGWGL-------- 253
                +   SP +G+++        + P      SL    P  GL  P G           
Sbjct: 2513 GQPPNFVRSPGTGAFVGTPSPMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTL 2572

Query: 254  -SPQGS--MVDERELHPAGTPEPPSSESS 279
              PQ +   V     HP+G+P  PSS S+
Sbjct: 2573 GKPQSTNYTVATGNFHPSGSPLGPSSGST 2601



 Score = 31.2 bits (69), Expect = 8.0
 Identities = 83/340 (24%), Positives = 111/340 (32%), Gaps = 37/340 (10%)

Query: 13  PEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASW 72
           PEA R  P  + S  +            E   L P      L+  P +    P PE +  
Sbjct: 567 PEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRL 626

Query: 73  DAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSP 132
              P  +P +   P E   SP   PE      +S  +PLP     R+    E       P
Sbjct: 627 SPPPEDSPMS-PPPEESPMSPP--PE------VSRLSPLPVV--SRLSPPPEESPLSPPP 675

Query: 133 RAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFT-----PPSTPTKTTYAL 187
             + T+    E    SP P     S      P+ PP  DS  +      P  P      L
Sbjct: 676 EESPTS-PPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQL 734

Query: 188 LPAC-GPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLD 246
            P   GPH   R  E  L     + P  SP      A+    +  P        P E   
Sbjct: 735 CPRSEGPHLSPRPEEPHLSPR-PEEPHLSPQ-----AEEPHLSPQPEEPCLCAVPEEPHL 788

Query: 247 FPSGWG--LSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDP 304
            P   G  LSPQ       ELH +   E P           S   +E H   L   + +P
Sbjct: 789 SPQAEGPHLSPQ-----PEELHLSPQTEEPHLSPVPEEPCLSPQPEESH---LSPQSEEP 840

Query: 305 MIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP 344
            +     P +  L  ++E   ++P  PE+  EE    P P
Sbjct: 841 CLSPR--PEESHLSPELEKPPLSP-RPEKPPEEPGQCPAP 877


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 99.8 bits (247), Expect = 2e-20
 Identities = 209/802 (26%), Positives = 275/802 (34%), Gaps = 134/802 (16%)

Query: 600  SAMTPPLPLQDTDLS-SAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK 658
            S  T P PL    L  SA + VA            L+       + P P         P 
Sbjct: 121  SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-------GTPS 173

Query: 659  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ 718
            P  A    +   E GL  P  SA   P P +    S           VS  +E   T P 
Sbjct: 174  PAMARRSRAAGTEVGLPRPAPSARPRP-PTEGPRKS-----------VSSASEHSTTEPS 221

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 778
             +A   P         ++    ++AT +S  A  G      +  TP  P       S PK
Sbjct: 222  PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG----PSARGTPRAPAHP----SQPK 273

Query: 779  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS----------APKPVAAATLVSQ 828
            P     +   Q    +T P+  A     PL  + L++           P P  AAT +  
Sbjct: 274  PKGLQALRPPQ----VTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPA 329

Query: 829  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATPVSQQAEEGLTLPQDSAMTA 884
                  TLP    +  PLPL     S+ P     P   ATP S QA   +T P    M A
Sbjct: 330  ------TLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPS-QAPPSMTTP---PMQA 379

Query: 885  PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNA 944
            P  LQ   P   P  L   T  +LQA         P+A ++  +   +LG  P  +  ++
Sbjct: 380  PPSLQTIPPIQVPHSL---TSPSLQAP------PSPLA-LSSLQATTSLG-SPTLQATHS 428

Query: 945  ALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLP--EPASGAGEEIA 1002
             L   P      Q Q     P+  A TP       DS      LSLP   P   +     
Sbjct: 429  FLTMSPR-----QTQASLTSPSRPASTP------PDSPPLQAPLSLPASPPLQTSLSPAV 477

Query: 1003 EALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGARE 1062
              LS P     L+A +     + P +P    +    + +  L P + +  P S      E
Sbjct: 478  SPLSSPLTIHPLQALSSLASHS-PQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLE 536

Query: 1063 -VPD---------APPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSC 1112
             +P          + P   P +      +P   +   S  +TP P  PS++AT       
Sbjct: 537  NLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPP----- 591

Query: 1113 PESSVGAVSSLDRGCPDAP-APTSAPTSQQPEPVLGLGSVEQPHEVP-----SVLGTPLL 1166
            P++     S   +G P  P +P + P  Q P P L L  ++ P   P     S L TP  
Sbjct: 592  PQAPPALASPPLQGLPSPPLSPLATPPPQAP-PXLALPPLQAPPSPPASPPLSPLATPSP 650

Query: 1167 QPPENLA--------KGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDS 1218
            Q P  LA           PS PV  P  P  S P  ++ +A PP + P        Q   
Sbjct: 651  QAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP--VSPSATPPSQAPPSLAAPPLQVPP 708

Query: 1219 VEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDL 1278
                 PP S    PP     P AA       PL   P     P SP +SP  A+   +  
Sbjct: 709  SPPASPPMSPSATPPPQAPPPLAA------PPLQVPPS---PPASPPMSPS-ATPPPRVP 758

Query: 1279 ALQILPPCQV---PPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGES 1335
             L   PP QV   PP S P SP       AP            SP A   GQ   S    
Sbjct: 759  PLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFS---P 815

Query: 1336 SAELDEQDILAPQTVQCPAQAP 1357
            SA L    +  P     P QAP
Sbjct: 816  SASLPMSPLATP-----PPQAP 832



 Score = 92.4 bits (228), Expect = 3e-18
 Identities = 187/763 (24%), Positives = 253/763 (33%), Gaps = 147/763 (19%)

Query: 483  VTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVT 542
            + P +    P LQ   +   TP +    + +T   ++       PS + I  I    S+T
Sbjct: 343  LAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAP------PSLQTIPPIQVPHSLT 396

Query: 543  AEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAM 602
            +  L  P    +L+       +L+    L  P+ +   +  T+ PRQ +  LT P   A 
Sbjct: 397  SPSLQAPPSPLALS-------SLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAS 449

Query: 603  TPP--LPLQ-----------DTDLSSAPKPVAAATIV------SQQAEEGLTLPQDSVMT 643
            TPP   PLQ            T LS A  P+++   +      S  A      P  S++ 
Sbjct: 450  TPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIM 509

Query: 644  PPLPLQDTELSSAPKPVAA--ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 701
            PPL   +T+ S AP  +    A+L +   E   +L      T   PL    L + P P  
Sbjct: 510  PPL---ETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAP 566

Query: 702  AATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSA 761
                        L  P     TPP    +T  S A  P  A   ++    +GL  P  S 
Sbjct: 567  CP----------LQAPPSPLTTPP---PETPSSIATPPPQAPPALASPPLQGLPSPPLSP 613

Query: 762  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 821
            +  P P     L+  P                L  P     +PPL    T    AP  +A
Sbjct: 614  LATPPPQAPPXLALPP----------------LQAPPSPPASPPLSPLATPSPQAPNALA 657

Query: 822  AATL---VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQ 878
               L    S      +  P     +PP+    T  S AP P  AA P        L +P 
Sbjct: 658  VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAP-PSLAAPP--------LQVPP 708

Query: 879  DSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVG-EALGPRP 937
                + P+    T P   P PLA A P  +      +P   P AT   +     A  P  
Sbjct: 709  SPPASPPMSPSATPPPQAPPPLA-APPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQ 767

Query: 938  APEEKNAALP----TVPEPAALDQVQQDDPQ--PAAEAGTPWAAQEDADSTLGMEALSLP 991
             P    A+LP      P P A   +     Q  P+  A  P  A     ++L M  L+ P
Sbjct: 768  VPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATP 827

Query: 992  EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEH 1051
             P      +    L+ P  +              P  P   TL+   +      P     
Sbjct: 828  PP------QAPPVLAAPLLQ------------VPPSPPASPTLQAPRRPPTP-GPDTSVS 868

Query: 1052 GPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDS 1111
            GPR  L  A   P  PP+  P    + L  P       S  STPE             DS
Sbjct: 869  GPRLTLALA-PGPPPPPSRSP---SSTLSGPDLAGHSSSATSTPEEL--------RGYDS 916

Query: 1112 CPESSVGAVSSLDRGCPDAPAPTSAPT--SQQPEPVLGLGSVEQPHEVPSVLGTPLLQPP 1169
             PE    A        PDA      P   S+ P P L               G PL  PP
Sbjct: 917  GPEGGAAASPP-----PDAELAACHPAAWSRGPAPPLAFRGAP---------GAPLPWPP 962

Query: 1170 ---ENLAKG----------QPSTPVDRPLGPDPSAPGTLAGAA 1199
                  A G          + +TP    L P PS PGT  G A
Sbjct: 963  ATGPGSADGLCTIYETEGPESATPAPGALDPGPS-PGTSGGKA 1004



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 243/992 (24%), Positives = 339/992 (34%), Gaps = 181/992 (18%)

Query: 498  VATRVTPQAGEEETDSTAGQESAAMAMP-QPSQEGISEILGQESVTAEKLPTPQEETSLT 556
            +++  TP +    +  +A     A A P QP  +G+      +++   ++  P+++ +  
Sbjct: 242  LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL------QALRPPQVTPPRKDAAPA 295

Query: 557  LCPDSPQNLKEEGGLDLPSGRK------PVAAATIVPRQAEEDLTLPQDSAMTPPLPLQD 610
            L P S   L        PSG K      P  AAT +P       TLP    +  PLPL  
Sbjct: 296  LGPLSSSPLATPS----PSGTKARPVPPPDNAATPLPA------TLPPSPPLATPLPLAP 345

Query: 611  TDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQA 670
               S+ P   +  T+ S  A      P  S+ TPP+            P +  T+   Q 
Sbjct: 346  PSPSAPP---SLQTLPSPPATPPSQAPP-SMTTPPMQA----------PPSLQTIPPIQV 391

Query: 671  EEGLTLPQDSAMTPPLPLQDTDL---SSAPKPVAAAT-----LVSQQAEEGLTLPQDSAM 722
               LT P  S   PP PL  + L   +S   P   AT     +  +Q +  LT P   A 
Sbjct: 392  PHSLTSP--SLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAS 449

Query: 723  TPP--LPLQ-----------DTDLSSAPKPVAAATLV------SQQAEEGLTLPQDSAMT 763
            TPP   PLQ            T LS A  P+++   +      S  A      P  S + 
Sbjct: 450  TPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIM 509

Query: 764  PPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAA 823
            PPL  Q + L+        A++ +   E   +L      T   PL    L + P P   A
Sbjct: 510  PPLETQSS-LAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCP---A 565

Query: 824  TLVSQQAEEGLTLPQD---SAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDS 880
                Q     LT P     S++  P P     L+S P     + P+S  A      P   
Sbjct: 566  PCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXL 625

Query: 881  AMTAPLPLQDTGPTSGP-EPLAVATPQTLQAEAGC---APGTEPVATMAQQEVGEALGPR 936
            A+  PL    + P S P  PLA  +PQ   A A     AP + P +   Q        P 
Sbjct: 626  ALP-PLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 684

Query: 937  PAPEEKNAALPTVPEPA-ALDQVQQDDPQPAAEAGTPWAAQE-DADSTLGMEALSLPEPA 994
             +P   +A  P+   P+ A   +Q     PA+   +P A     A   L    L +P P+
Sbjct: 685  VSP---SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVP-PS 740

Query: 995  SGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPR 1054
              A   ++ + + P R   L A       A P       L+V       L        P 
Sbjct: 741  PPASPPMSPSATPPPRVPPLLA-------APP-------LQVPPSPPASL--------PM 778

Query: 1055 SALGGAREVPDAPPAACPEVSQARLLSPAREERG-----------LSGKSTPEPTLPSAV 1103
            S L  A+  P APPA      QA L SP     G           +S  +TP P  P  +
Sbjct: 779  SPL--AKPPPQAPPALATPPLQA-LPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVL 835

Query: 1104 ATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGT 1163
            A  A L   P S     +S     P  P PT  P +    P L L     P   PS   +
Sbjct: 836  A--APLLQVPPSPP---ASPTLQAPRRP-PTPGPDTSVSGPRLTLALAPGPPPPPSRSPS 889

Query: 1164 PLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEE 1223
              L  P+       +T     L    S P   A A+ PP    A C              
Sbjct: 890  STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAAC-------------- 935

Query: 1224 PPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQIL 1283
                           PAA +  G   PL        +P +PL  P      + D      
Sbjct: 936  --------------HPAAWS-RGPAPPLA----FRGAPGAPLPWPPATGPGSAD------ 970

Query: 1284 PPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDE-- 1341
              C +    GP+S     G   P               A G+G  + S     A L E  
Sbjct: 971  GLCTIYETEGPESATPAPGALDPGPSPGTSG----GKAAAGAGAGASSRSPKQARLGELP 1026

Query: 1342 ---------QDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGV 1392
                     Q +L+   +   A+  AGGS      A+       AR A+S   L +   +
Sbjct: 1027 LGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAEL 1086

Query: 1393 TRITIQKSKNILFVIA-KPDVFKSPASDTYVV 1423
                 +   +I  V +  PD   SP  D  VV
Sbjct: 1087 LSPLDESRASITSVTSFSPDDVASPQGDWTVV 1118



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 135/546 (24%), Positives = 178/546 (32%), Gaps = 55/546 (10%)

Query: 909  QAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAE 968
            +A+AG A  T                PRP P    AAL  +    A+ +    +      
Sbjct: 7    KAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIG 66

Query: 969  AGT-----PWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDG 1023
              T     P A    +  T      S P PASG GE    A +          RA     
Sbjct: 67   GATIPESAPRAGPTRSAGTSSRNPASRP-PASGRGERAPPAKNTSPGPVSSPGRA--SGT 123

Query: 1024 AKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALG-GAREVPDAPPAACPEVSQARLLSP 1082
             +P    ++ L + + +E   +  A E   RSAL  GAR     P    P  + AR    
Sbjct: 124  TRPGPLGQKGLRI-SAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRA 182

Query: 1083 AREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDA------PA---- 1132
            A  E GL   +      P       S+ S  E S    S   R  P A      PA    
Sbjct: 183  AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSL 242

Query: 1133 -----PTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGP 1187
                 P S+P    P    G          P   G   L+PP+     + + P   PL  
Sbjct: 243  SSSATPLSSPARSGPS-ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301

Query: 1188 DPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAA-AAVSG 1246
             P A  + +G    P+ PP       P   +     PP  L  P P A   P+A  ++  
Sbjct: 302  SPLATPSPSGTKARPVPPPDNAATPLP---ATLPPSPP--LATPLPLAPPSPSAPPSLQT 356

Query: 1247 TTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVP---PPSGPQSPAGPQGL 1303
               P  T P  S +P S    P  A       +LQ +PP QVP        Q+P  P  L
Sbjct: 357  LPSPPATPP--SQAPPSMTTPPMQAPP-----SLQTIPPIQVPHSLTSPSLQAPPSPLAL 409

Query: 1304 S---------APEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPA 1354
            S         +P  Q     L   SPR   +   S S   +S   D   + AP  +  PA
Sbjct: 410  SSLQATTSLGSPTLQATHSFLTM-SPRQTQASLTSPSR-PASTPPDSPPLQAP--LSLPA 465

Query: 1355 QAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFK 1414
              P   S         S       +A+S L     Q      I         +A P +  
Sbjct: 466  SPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQT 525

Query: 1415 SPASDT 1420
             PAS T
Sbjct: 526  PPASLT 531



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 65/279 (23%), Positives = 87/279 (31%), Gaps = 45/279 (16%)

Query: 80  PSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTAL 139
           PS    P +   +P+  P  L +       PL A   P      ET  ++ +P       
Sbjct: 539 PSLAPPPLQTASAPLTTPH-LETPPCPAPCPLQAPPSPLTTPPPETPSSIATP------- 590

Query: 140 RDQEGGHASPDPPPELCSQGDLSVPSPP------PDPDS--------FFTPPSTPTKTTY 185
                    P  PP L S     +PSPP      P P +           PPS P     
Sbjct: 591 --------PPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASP-- 640

Query: 186 ALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGL 245
            L P   P   A ++ A    +   SPP SP      +   S   SPS +    AP    
Sbjct: 641 PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLA 700

Query: 246 DFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPM 305
             P     SP  S        P     PP +   L    S               A+ PM
Sbjct: 701 APPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPP-------------ASPPM 747

Query: 306 IPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP 344
            P+A  P +   +     ++V P  P       +A P P
Sbjct: 748 SPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPP 786



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 76/309 (24%), Positives = 105/309 (33%), Gaps = 72/309 (23%)

Query: 13  PEADRPGPRTDLSCDAAAATT----------ILGGDRREPCA------LTP-------GP 49
           P     GPR  +S  +  +TT            GG  + P +       TP       GP
Sbjct: 198 PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGP 257

Query: 50  SHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGP---SPMLLPEGLSSQAL- 105
           S       P+ P ++P+P+G      P   P         GP   SP+  P    ++A  
Sbjct: 258 SARGTPRAPAHP-SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARP 316

Query: 106 -----STEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGD 160
                +   PLPATL P   +   T   L  P               SP  PP L  Q  
Sbjct: 317 VPPPDNAATPLPATLPPSPPLA--TPLPLAPP---------------SPSAPPSL--QTL 357

Query: 161 LSVPSPPPD--PDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSG 218
            S P+ PP   P S  TPP     +   + P   PH         L    L +PP+  + 
Sbjct: 358 PSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPH--------SLTSPSLQAPPSPLAL 409

Query: 219 SYITADGDSWASSPSCSLSLLAPA-----EGLDFPSGWGLSPQGSMVDERELH-PAGTPE 272
           S + A     + +   + S L  +       L  PS     P  +  D   L  P   P 
Sbjct: 410 SSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPS----RPASTPPDSPPLQAPLSLPA 465

Query: 273 PPSSESSLS 281
            P  ++SLS
Sbjct: 466 SPPLQTSLS 474


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 95.1 bits (235), Expect = 5e-19
 Identities = 221/1073 (20%), Positives = 362/1073 (33%), Gaps = 158/1073 (14%)

Query: 468  VTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQP 527
            V+   +A  + ST + TP          V+ +  VT       + +TA   S  ++ P  
Sbjct: 2876 VSTTPVASSEASTLSTTP----------VDTSIPVTTSTEGSSSPTTAEGTSMPISTPSE 2925

Query: 528  SQEGISEIL-------GQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSG---- 576
                ++ IL       G E+ T    P     T +T   ++  +     G  +P      
Sbjct: 2926 VSTPLTSILVSTVPVAGSEASTLSTTPV-DTRTPVTTSAEASSSPTTAEGTSMPISTPGE 2984

Query: 577  -RKPVAAATI--VPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEG 633
             R P+ + ++  +P  + E  TL +  A T       T+ SS+P       I      EG
Sbjct: 2985 RRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEG 3044

Query: 634  LT-LPQDSVMTPPLPLQDTE-LSSAP----KPVAAATLVSQQAE--EGLTLPQDSAMTPP 685
             T L    V T P+ + +   LS+ P     PV  +T VS      EG ++P  +     
Sbjct: 3045 STPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGS 3104

Query: 686  LPLQDTDLSSAP-----------KPVAAATLVSQQAE--------EGLTLPQDSAMTPPL 726
             PL    +S+ P            PV  +T V+   E        EG ++P  +      
Sbjct: 3105 TPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGST 3164

Query: 727  PL-------------QDTDLSSAP----KPVAAAT-LVSQQAEEGLTLPQDSAMTPPLPL 768
            PL             +D+ LS+ P     PV  +T   S    EG ++P  +      PL
Sbjct: 3165 PLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPL 3224

Query: 769  QDTDLSSAPKPVAAATIVSQQAEEG---LTLPQDSAMTPP------LPLQDTDLSSAP-- 817
                +S+ P   + A+I+S    +    LT   +++ +PP      +P       S P  
Sbjct: 3225 TSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLT 3284

Query: 818  -KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT--PVSQQAEEGL 874
              PV+  T+ S +     T P D++     P+     +S+  P+A  T  P S  +E   
Sbjct: 3285 SMPVSTTTVASSETSTLSTTPADTST----PVTTYSQASSSPPIADGTSMPTSTYSEGST 3340

Query: 875  TLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALG 934
             L   S  T P+ +     T    P+  +TP T   EA  +P T    ++      E   
Sbjct: 3341 PLTNMSFSTTPV-VSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTT 3399

Query: 935  PRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPA 994
            P        A++P    P    +V      P         + E + S    E  SLP   
Sbjct: 3400 PL-------ASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTST 3452

Query: 995  SGAG---------------EEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQ 1039
            +  G                  A  LS    +        +   + P + +  ++     
Sbjct: 3453 TSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTA 3512

Query: 1040 QEGGL----KPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTP 1095
             EG       P++      S        P          SQA   SPA  +      STP
Sbjct: 3513 GEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQAS-SSPATLQVTTMRMSTP 3571

Query: 1096 EPTLPS--AVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQ 1153
                 S   +   ++  +  E+S  +  S+DR  P   +  S  T   PE       +  
Sbjct: 3572 SEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPE------VITL 3625

Query: 1154 PHEVPSVLGTPLLQPPENLAK------GQPST-PVDRPL-----GPDPSAPGTLAGAALP 1201
            P   PS + TPL   P +         G  ST PVD            S+P T  G  +P
Sbjct: 3626 PMSTPSEVSTPLTIMPVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMP 3685

Query: 1202 ---PLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVS 1258
               P E   P          V   E  GS    P      P    V+ +T+ + +   + 
Sbjct: 3686 IWTPSEGSTPLTTMPVSTTRVTSSE--GSTLSTPSVVTSTP----VTTSTEAISSSATLD 3739

Query: 1259 LSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEED 1318
             +  S  +  +++++    + +   P  + P  S P  P+    +S     E        
Sbjct: 3740 STTMSVSMPMEISTL-GTTILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEG-----SS 3793

Query: 1319 SPRAL-GSGQHSDSHGESSAELDEQDILAPQTVQCPAQA------PAGGSEETIAKAKQS 1371
            SP  L G+     S     + L    +++P +V  P++A      P   S   +   K  
Sbjct: 3794 SPTTLEGTTTMPMSTTSERSTLLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAG 3853

Query: 1372 RSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVF 1424
                 A     ++ +   +     T+  S  +        +  +P  DT   F
Sbjct: 3854 SFSIPAEVTTIRISITSERSTPLTTLLVSTTLPTSFPGASIASTPPLDTSTTF 3906



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 214/972 (22%), Positives = 330/972 (33%), Gaps = 120/972 (12%)

Query: 384  TSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSW 443
            TS  S  S   +        + S E    +T+  DS       S   +    A+D +++ 
Sbjct: 385  TSTLSEGSTPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIAT 444

Query: 444  AVEAAPQTSDRGAYLSQRQELISEVTEEGLA-LGQESTATVTPHTLQVAPGLQVEVATRV 502
            +  +   T      +S      SE +      +  ++  T +       P  +V      
Sbjct: 445  STPSEGSTPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTS 504

Query: 503  TPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDS- 561
            TP  G     ST     +   MP  S E  S +      T+  + T  E +S +  P+  
Sbjct: 505  TPSEG-----STPLTSMSVSTMPVASSEA-STLSTTPVDTSTPVTTSSEASSSSTTPEGT 558

Query: 562  --PQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKP 619
              P +   EG   L +   PV+   +V  +A    T P DS        + +  S+  + 
Sbjct: 559  SIPTSTPSEGSTPLTN--MPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEG 616

Query: 620  VAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTE-LSSAPKPVAAATLVSQQAEEGLTLPQ 678
             +  T  S  +E G T+   SV T  +   +   LS+ P         S +A    T  +
Sbjct: 617  TSMPT--STYSERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAE 674

Query: 679  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 738
             ++M P     +        PV    + S +A    T P D++ TP      T+ SS+P 
Sbjct: 675  GTSM-PTSTYTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTS-TPVTT--STEASSSPT 730

Query: 739  PVAAATLVSQQAEEGLTLPQDSAMTPPL--PLQDTDLSSAPKPVAAATIVSQQAEEGLTL 796
                A++ +    EG T      ++  L    + + LS+ P   +     S +A    T 
Sbjct: 731  TADGASMPTSTPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTT 790

Query: 797  PQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 856
             + ++M    P + + L ++  PV+   + S +A    T P DS    P+    T++SS+
Sbjct: 791  TEGTSMPISTPSEGSPLLTSI-PVSITPVTSPEASTLSTTPVDS--NSPVTTS-TEVSSS 846

Query: 857  PKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAP 916
            P P    +  +    EG T      ++  L       T    P+  +TP T   EA  +P
Sbjct: 847  PTPAEGTSMPTSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSP 906

Query: 917  GTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQ 976
             T    +M          P   P E +  L ++P+           P  ++EA T  A  
Sbjct: 907  TTSEGTSM----------PTSTPGEGSTPLTSMPDSTT--------PVVSSEARTLSATP 948

Query: 977  EDADS--TLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETL 1034
             D  +  T   EA S P  A G     +   S P            G      +P   TL
Sbjct: 949  VDTSTPVTTSTEATSSPTTAEGT----SIPTSTPSE----------GTTPLTSTPVSHTL 994

Query: 1035 EVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKST 1094
             V N +   L     +    + L  + E    PP A                    G S 
Sbjct: 995  -VANSEASTLSTTPVD--SNTPLTTSTEASSPPPTA-------------------EGTSM 1032

Query: 1095 PEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPT---SQQPEPVLGLGSV 1151
            P  T PS  +T   L   P S+    SS        PA TS P    SQ           
Sbjct: 1033 PTST-PSEGST--PLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADGT 1089

Query: 1152 EQPHEVPSVLGTPLLQPP-------ENLAKGQPSTPVDRPL-----GPDPSAPGTLAGAA 1199
              P    S   TPL   P        + A    +TPVD  +         S+P T  G +
Sbjct: 1090 SMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAEGTS 1149

Query: 1200 L---PPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSG--------TT 1248
            +   PP E   P L   P   ++       +L   P  +  Q A +  +         T+
Sbjct: 1150 IPTSPPSEGTTP-LASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTAEVTS 1208

Query: 1249 QPLGT-GPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPP-----SGPQSPAGPQG 1302
             P  T G R +     P+    VAS +A  L+     P     P         SP   +G
Sbjct: 1209 MPTSTPGERSTPLTSMPVRHTPVASSEASTLSTS---PVDTSTPVTTSAETSSSPTTAEG 1265

Query: 1303 LSAPEQQEDEDS 1314
             S P     E S
Sbjct: 1266 TSLPTSTTSEGS 1277



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 287/1433 (20%), Positives = 495/1433 (34%), Gaps = 198/1433 (13%)

Query: 12   LPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGAS 71
            +P +     RT L+     +TT++        + TP  +   +T   +   AR  P  + 
Sbjct: 855  MPTSTYSEGRTPLT-SMPVSTTLVATSAISTLSTTPVDTSTPVT---NSTEARSSPTTSE 910

Query: 72   WDAGPGGAPSAWADPGEGGP---SPMLLPEG--LSSQALSTEAPLP----ATLEPRIVMG 122
              + P   P   + P    P   +P++  E   LS+  + T  P+     AT  P    G
Sbjct: 911  GTSMPTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEG 970

Query: 123  --------EETCQALLSPRAARTALRDQEGGHASPDPPPE---LCSQGDLSVPSPPPDPD 171
                     E    L S   + T + + E    S  P      L +  + S  SPPP  +
Sbjct: 971  TSIPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEAS--SPPPTAE 1028

Query: 172  SFFTPPSTPTK--TTYALLPACGPHGDARDSEAELRDELLDSPPASP----SGSYITADG 225
                P STP++  T    +P       + ++          S P +     S S  TADG
Sbjct: 1029 GTSMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADG 1088

Query: 226  DSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSS 285
             S  +S     S   P   +   +   +S + S +      P  T  P ++ +  S+  +
Sbjct: 1089 TSMPTSTYSEGS--TPLTSVPVSTRLVVSSEASTLSTT---PVDTSIPVTTSTEASSSPT 1143

Query: 286  SSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEA--VEVTPLSPEEEEEEAVADPD 343
            ++ G            ++   P A +P   +L+   EA  +  TP+  + +   +     
Sbjct: 1144 TAEGTSIPTSP----PSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASS 1199

Query: 344  PGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDER 403
            P           ST       L+ + +             T  ASS++ + S +  D   
Sbjct: 1200 PPPTAEVTSMPTSTPGERSTPLTSMPVRH-----------TPVASSEASTLSTSPVDTST 1248

Query: 404  --LYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSD-------- 453
                S E  +  T  + +   T   S G           VS  +  +P+ S         
Sbjct: 1249 PVTTSAETSSSPTTAEGTSLPTSTTSEGSTLLTSIP---VSTTLVTSPEASTLLTTPVDT 1305

Query: 454  RGAYLSQRQELISEVTEEGLALGQES--------------TATVTPHTLQVAPGLQVEVA 499
            +G  ++  +   S    EG ++   +              T  V    + +     V+ +
Sbjct: 1306 KGPVVTSNEVSSSPTPAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNS 1365

Query: 500  TRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETS-LTLC 558
            T VT     E   S    E  +M    PS EG + +    S+     P    E S L+  
Sbjct: 1366 TPVTTST--EACSSPTTSEGTSMPNSNPS-EGTTPLT---SIPVSTTPVVSSEASTLSAT 1419

Query: 559  PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPK 618
            P           +D  +     A AT  P  AE  +++P  +      PL+   +S+ P 
Sbjct: 1420 P-----------VDTSTPGTTSAEATSSPTTAE-GISIPTSTPSEGKTPLKSIPVSNTPV 1467

Query: 619  PVAAATIVSQQAEEGLT--LPQDSVMTPPLPLQDTELS-SAPK---------PVAAATLV 666
              + A+ +S    +  +  +   +V + P P + T ++ S P          PV+  T+ 
Sbjct: 1468 ANSEASTLSTTPVDSNSPVVTSTAVSSSPTPAEGTSIAISTPSEGSTALTSIPVSTTTVA 1527

Query: 667  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL 726
            S +     T P   A+T       +  SS+P      ++ +    EG T      ++  L
Sbjct: 1528 SSEINSLSTTP---AVTSTPVTTYSQASSSPTTADGTSMQTSTYSEGSTPLTSLPVSTML 1584

Query: 727  PLQDTDLSSAPKPVAAATLVSQQAE-EGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATI 785
             +     + +  P+ + T V+   E    T  + S+MT   P + + L ++  PV+   +
Sbjct: 1585 VVSSEANTLSTTPIDSKTQVTASTEASSSTTAEGSSMTISTPSEGSPLLTSI-PVSTTPV 1643

Query: 786  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP 845
             S +A    T P DS    P+ +  T++SS+P P    ++ +    EG T P  S     
Sbjct: 1644 ASPEASTLSTTPVDS--NSPV-ITSTEVSSSPTPAEGTSMPTSTYTEGRT-PLTSITVRT 1699

Query: 846  LPLQDTDLSS-APKPVAAATPVSQQAE--------EGLTLPQDSAMTAPLPLQDTGPTSG 896
             P+  + +S+ +  PV  +TPV+   E        EG ++P  +      PL     ++ 
Sbjct: 1700 TPVASSAISTLSTTPVDNSTPVTTSTEARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTT 1759

Query: 897  P-----------EPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPA------- 938
            P            P+  +TP T   EA  +P T    ++    + E + P  +       
Sbjct: 1760 PVLSSEASTLSATPIDTSTPVTTSTEATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTL 1819

Query: 939  -PEEKNAALPTVP----EPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEP 993
                + + L T P     P          P PA   GT  A    ++ +  +   S+P  
Sbjct: 1820 VANSEASTLSTTPVDSNSPVVTSTAVSSSPTPA--EGTSIATSTPSEGSTAL--TSIPVS 1875

Query: 994  ASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGP 1053
             +         LS            +    + P +    ++     +EG  +P       
Sbjct: 1876 TTTVASSETNTLSTTPAVTSTPVTTYAQVSSSPTTADGSSMPTSTPREG--RPPLTSIPV 1933

Query: 1054 RSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPT-LPSAVATEAS--LD 1110
             +    + E+           +     S A      S  +T + T +P+   +E S  L 
Sbjct: 1934 STTTVASSEINTLSTTLADTRTPVTTYSQAS-----SSPTTADGTSMPTPAYSEGSTPLT 1988

Query: 1111 SCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPE----PVLGLGSVEQPHEVPSVLGTPLL 1166
            S P S+   VSS        P  TS P +   E    P    G+  Q    PS   TPL 
Sbjct: 1989 SMPLSTTLVVSSEASTLSTTPVDTSTPATTSTEGSSSPTTAGGTSIQT-STPSERTTPLA 2047

Query: 1167 QPPENL-----AKGQ--PSTPVDRPL----GPDPSAPGTLAGAALPPLEPP--APCLCQD 1213
              P +      ++G    +TPVD         + S+  T  G+++    P   +P L   
Sbjct: 2048 GMPVSTTLVVSSEGNTLSTTPVDSKTQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSI 2107

Query: 1214 PQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGT-GPRVSLSPHS----PLLSP 1268
            P   +        +L   P  +   P   +   ++ P+ T G  +  S +S    PL S 
Sbjct: 2108 PLSTTPVASPEASTLSTTPVDSN-SPVITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSM 2166

Query: 1269 KVASMDAKDLALQIL--PPCQVPPP-----SGPQSPAGPQGLSAPEQQEDEDS 1314
             V++      A+  L   P     P         SP   +G S P     E S
Sbjct: 2167 PVSTTVVASSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSMPTSTPSEGS 2219



 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 212/1036 (20%), Positives = 357/1036 (34%), Gaps = 173/1036 (16%)

Query: 384  TSAASSDSDSASYAEADDERLY-SGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS 442
            T +A++ +   +     + R+Y S   + + T ++ SV            G+ +   T +
Sbjct: 61   TGSAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSD-------TPGVSSTRMTPT 113

Query: 443  WAVEAAPQTSDRGA-YLSQRQELISEVTEEG----LALGQESTATVTPHTLQVAPGLQVE 497
             +   +  TSD    + S  ++  S  T EG    ++   E + + T   +  AP    E
Sbjct: 114  ESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISSTMAFVSTAPLPSFE 173

Query: 498  VATRVTPQAGEEETDSTAGQESAAMAMPQPS-------QEGISEILGQESVTAEK----- 545
              T +T +       +T+ Q S++   P+ +        EG + +    + T +      
Sbjct: 174  AYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPLTSMPASTMKVASSEA 233

Query: 546  ---LPTPQE-ETSLTLCPDSPQNLKEEGGLDL----PSG------RKPVAAATIVPRQAE 591
               L TP E  T +T+   +  +     G  L    PSG      R P++   +V  +A 
Sbjct: 234  ITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTPLTRMPLSVMLVVSSEAS 293

Query: 592  EDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLT---------------- 635
               TL    A T    +  T+ SS+P      +I +    EG T                
Sbjct: 294  ---TLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGSTPLTSTPASTMPVATSE 350

Query: 636  ---LPQDSVMTPPLPLQDTELSSAP----------------------KPVAAATLVSQQA 670
               L    V T  L    TE SS P                       PV+   + S +A
Sbjct: 351  MSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGSTPLTNMPVSTILVASSEA 410

Query: 671  EEGLTLPQDS---------AMTPPLPLQDTDLSSA----------PKPVAAATLVSQQAE 711
                T+P DS         A + P   +DT ++++            PV+   + S +A 
Sbjct: 411  STTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEGSTPLTSMPVSTTPVASSEAS 470

Query: 712  EGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 771
               T P DS          T+ SS+P      ++ +    EG T P  S     +P+  +
Sbjct: 471  NLSTTPVDSKTQ---VTTSTEASSSPPTAEVNSMPTSTPSEGST-PLTSMSVSTMPVASS 526

Query: 772  D---LSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQ-DTDLSSAPKPVAAATLVS 827
            +   LS+ P   +     S +A    T P+ +++    P +  T L++   PV+   +VS
Sbjct: 527  EASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPSEGSTPLTN--MPVSTRLVVS 584

Query: 828  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLP 887
             +A    T P DS     +       SS+      + P S  +E G T+   S  T  L 
Sbjct: 585  SEASTTSTTPADS--NTFVTTSSEASSSSTTAEGTSMPTSTYSERGTTITSMSVSTT-LV 641

Query: 888  LQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPA--------P 939
                  T    P+   TP T   EA  +  T    +M      E   P  +         
Sbjct: 642  ASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTSTYTEGSTPLTSMPVNTTLVA 701

Query: 940  EEKNAALPTVP----EPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPAS 995
              + + L T P     P          P  A  A  P +   +  + L     S+P   +
Sbjct: 702  SSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTSTPSEGSTPL----TSMPVSKT 757

Query: 996  GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRS 1055
                  A  LS    +        T     P + +  ++ +    EG   PL       +
Sbjct: 758  LLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPISTPSEG--SPLL------T 809

Query: 1056 ALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPE--PTLPSAVATE--ASLDS 1111
            ++  +     +P A+    +     SP      +S   TP    ++P++  +E    L S
Sbjct: 810  SIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMPTSTYSEGRTPLTS 869

Query: 1112 CPES----SVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQ 1167
             P S    +  A+S+L     D   P +  T  +  P    G+   P   P    TPL  
Sbjct: 870  MPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGT-SMPTSTPGEGSTPLTS 928

Query: 1168 PPENL-------AKGQPSTPVD--RPLGPD---PSAPGTLAGAALP---PLEPPAPCLCQ 1212
             P++        A+   +TPVD   P+       S+P T  G ++P   P E   P L  
Sbjct: 929  MPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTSIPTSTPSEGTTP-LTS 987

Query: 1213 DPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHS--------- 1263
             P   ++       +L   P  +      +  + +  P   G  +  S  S         
Sbjct: 988  TPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGTSMPTSTPSEGSTPLTRM 1047

Query: 1264 PLLSPKVASMDAKDLA 1279
            P+ +  VAS +   L+
Sbjct: 1048 PVSTTMVASSETSTLS 1063



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 248/1216 (20%), Positives = 409/1216 (33%), Gaps = 147/1216 (12%)

Query: 88   EGGPSPMLLPEGLS---SQALSTEAPLPATLEPRI-VMGEETCQALLSPRAARTALRDQE 143
            EG  SP    EG S   S       PL + L   + V G E      +P   RT +    
Sbjct: 2905 EGSSSPTTA-EGTSMPISTPSEVSTPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTS- 2962

Query: 144  GGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAE 203
               AS  P     +   +S P     P +  +  + P  ++ A   +  P   A  S   
Sbjct: 2963 -AEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSRTP---ADTSTPV 3018

Query: 204  LRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGS---MV 260
                   S P +  G+ I     S  S+P  S+ +      +   S    +P  S   +V
Sbjct: 3019 TTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVV 3078

Query: 261  DERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQ 320
               E+  + TP   +S   +S  S  S    G             +P +  P   S I  
Sbjct: 3079 TSTEVSSSPTPAEGTS-MPISTYSEGSTPLTG-------------VPVSTTPVTSSAIST 3124

Query: 321  VEAVEVTPLSPEEEEEEAVADPDPGGDLA---GEGEEDSTSASFLQSLSDLSITEGMDEA 377
            +    V   +P     EA + P      +       E ST  +++   + L ++      
Sbjct: 3125 LSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTL 3184

Query: 378  FAFRDDTSA-ASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQA 436
             A   DTS   ++ +++ S   A+   + +  P    T L          +   A  L  
Sbjct: 3185 SATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILST 3244

Query: 437  QDG------TVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQV 490
                     T S    ++P T++ G  +              + +   + A+    TL  
Sbjct: 3245 TPVDSNTPLTTSTEASSSPPTAE-GTSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLST 3303

Query: 491  APGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQ 550
             P    + +T VT  +    +   A   S    MP  +    S  L   S +   + + +
Sbjct: 3304 TPA---DTSTPVTTYSQASSSPPIADGTS----MPTSTYSEGSTPLTNMSFSTTPVVSSE 3356

Query: 551  EETSLTLCPDS--PQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPL 608
              T  T   D+  P     E  L         A  T +P  +  + T P  S      P+
Sbjct: 3357 ASTLSTTPVDTSTPVTTSTEASLS-----PTTAEGTSIPTSSPSEGTTPLASMPVSTTPV 3411

Query: 609  QDTDLSS-APKPVAAATIVSQQAE--------EGLTLPQDSVMTPPLPLQDTELSSAPKP 659
              +++++ +  PV + T+V+   E        EG +LP  +      PL    LS+ P  
Sbjct: 3412 VSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLSTTPVA 3471

Query: 660  VAAATLVSQQAEEGLT-----LPQDSAMTPP----LPLQDTDLSSAP---KPVAAATLVS 707
             + A+ +S    +  T      P +S+ T      +P       S P    PV+   + S
Sbjct: 3472 SSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVAS 3531

Query: 708  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 767
             +A    T P DS          +  SS+P  +   T+      EG      S++T  L 
Sbjct: 3532 SEASTLSTTPVDSNT---FVTSSSQASSSPATLQVTTMRMSTPSEG-----SSSLTTML- 3582

Query: 768  LQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP----LPLQDTDLSSAP---KPV 820
            L  T ++S+     +   V +      +   +S  TPP    LP+      S P    PV
Sbjct: 3583 LSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIMPV 3642

Query: 821  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDS 880
            +  ++   +A    TLP D++ TP +    T +SS+P      T       EG T     
Sbjct: 3643 STTSVTISEAGTASTLPVDTS-TPVIT--STQVSSSPVTPEGTTMPIWTPSEGSTPLTTM 3699

Query: 881  AMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGE--------A 932
             ++        G T     +  +TP T   EA  +  T    TM+     E         
Sbjct: 3700 PVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGTTIL 3759

Query: 933  LGPRPA---PEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALS 989
            +   P    PE    ++P+V    ++    +    P    GT             +    
Sbjct: 3760 VSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTV 3819

Query: 990  LPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVE--NQQEGGLKPL 1047
            L  P S      A  LS P  +        T  G+     +  T+ +   +++   L  L
Sbjct: 3820 LISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSERSTPLTTL 3879

Query: 1048 AQEHGPRSALGGAREVPDAPP-------------AACPEVSQARLLSPAREERGLSGKST 1094
                   ++  GA  +   PP             A+ P +  A  +S +    G    ST
Sbjct: 3880 LVSTTLPTSFPGA-SIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEG----ST 3934

Query: 1095 PEPT--LPSAVATEASLDSCPESSVGAVSS--LDRGCPDAPAPTSAPTSQQPEPVLGLGS 1150
            P  T  +PS   T ++ D  P ++ GAVS+  +     + P+ +S+ T+          +
Sbjct: 3935 PGTTIFIPSTPVTSSTADVFP-ATTGAVSTPVITSTELNTPSTSSSSTTTSFSTTKEFTT 3993

Query: 1151 VEQPHEVPSVLGTPLLQP--PENLAKG---------QPSTP------VDRPLGP--DPSA 1191
                   P    T    P  P   ++G           STP        RP+ P  + S 
Sbjct: 3994 PAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVTPSSESSR 4053

Query: 1192 PGTLAGAALPPLEPPA 1207
            P T+    +PP  PPA
Sbjct: 4054 PSTITSHTIPPTFPPA 4069



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 265/1203 (22%), Positives = 403/1203 (33%), Gaps = 167/1203 (13%)

Query: 217  SGSYITADGDS-WASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPS 275
            S S  TA G S   S+PS       P  G+   +   +S +G+ +         TP    
Sbjct: 2023 SSSPTTAGGTSIQTSTPS---ERTTPLAGMPVSTTLVVSSEGNTLST-------TPVDSK 2072

Query: 276  SESSLSADSSSSWGQEGHFFDLDFLAN-DPM---IPAALLPFQGSLIFQVEAVEVTPLSP 331
            ++ + S ++SSS   EG    +   +   P+   IP +  P        +    V   SP
Sbjct: 2073 TQVTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSP 2132

Query: 332  EEEEEEAVADPDP--GGDLAGEGEED----------STSASFLQSLSDLSITEGMDEAFA 379
                 E  + P P  G  +      D          ST+     ++S LS T  +D +  
Sbjct: 2133 VITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTP-VDTSTP 2191

Query: 380  FRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDG 439
              + T A SS + S   +           P     +    V  +E  +        +   
Sbjct: 2192 VTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTSTPV 2251

Query: 440  TVSWAVEAAPQTSDRGAY----LSQRQELISE--VTEEGLALGQESTATVTPHTLQVAPG 493
            T S    ++P T++  +     LS+    ++   V+   +A  + ST + TP        
Sbjct: 2252 TTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDSNTPFT 2311

Query: 494  LQVEVATRVTPQAGEEETDSTAGQESAAMA-MPQPSQEGISEILGQESVTAEKLPTP--- 549
               E ++      G     ST+ + +  +  MP  +    S      S T     TP   
Sbjct: 2312 TSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPADTSTPVTT 2371

Query: 550  --QEETSLTLCPDS--PQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPP 605
              Q  +S T   D+  P +   EG   L S   PV+   +V  +A    T P D++ TP 
Sbjct: 2372 YSQAGSSPTTADDTSMPTSTYSEGSTPLTS--VPVSTMPVVSSEASTHSTTPVDTS-TPV 2428

Query: 606  LPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATL 665
                 T+ SS+P      +I +    EG T           PL       A  PV+   +
Sbjct: 2429 TT--STEASSSPTTAEGTSIPTSPPSEGTT-----------PL-------ASMPVSTTPV 2468

Query: 666  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAM--T 723
            VS +A    T P D++ TP      T+ SS+P       +    A EG TL     +  T
Sbjct: 2469 VSSEAGTLSTTPVDTS-TPMTT--STEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTT 2525

Query: 724  PPLPLQDTDLSSAP----KPVAAATLVSQQAE--EGLTLPQDSAMTPPLPLQDTDLSSAP 777
            P    + + LS+ P     PV  +T +S  A   EG ++P  +      PL+   +S+ P
Sbjct: 2526 PVASPEASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKP 2585

Query: 778  KPVAAATIVSQQAEEGLTLPQDSAM---------TPPLPLQDTDLS-SAPKPVAAAT--- 824
                   + S +A    T P D+++         + P   +DT +  S P  V+ +    
Sbjct: 2586 -------LASSEASTLSTTPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSI 2638

Query: 825  LVSQQ---AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSA 881
            LVS     + E  TL      T  L    T  SS+P     ++  +    E  T   +  
Sbjct: 2639 LVSTMPVASSEASTLSTTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNIL 2698

Query: 882  MTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEE 941
            ++  L       T    P+  +TP T  AEA  +P T    +M      +  G  P    
Sbjct: 2699 VSTTLLANSEASTLSTTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSD--GSTPLTSI 2756

Query: 942  KNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEI 1001
              + LP     A+       D        T     E + S    E  S+  P S   E  
Sbjct: 2757 LVSTLPVASSEASTVSTTAVDTSIPVTTST-----EASSSPTTAEVTSM--PTSTPSETS 2809

Query: 1002 AEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEH---GPRSALG 1058
                S P     +   A +  G    +P   +  V    +    P   E       +A  
Sbjct: 2810 TPLTSMPVNHTPV---ASSEAGTLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASE 2866

Query: 1059 GAREVPDAPPAACPEV-SQARLLSP---------AREERGLSGKSTPEPT-LPSAVATEA 1107
            G+  +   P +  P   S+A  LS               G S  +T E T +P +  +E 
Sbjct: 2867 GSTLLTSIPVSTTPVASSEASTLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEV 2926

Query: 1108 S--LDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPE-------------PVLGLGSVE 1152
            S  L S   S+V    S        P  T  P +   E             P+   G   
Sbjct: 2927 STPLTSILVSTVPVAGSEASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERR 2986

Query: 1153 QPHEVPSVLGTPLLQPPENLAKGQP---STPVDRPLGPDPSAPGTLAGAALP---PLEPP 1206
             P    SV   P+     +     P   STPV        S+P T  G  +P   P E  
Sbjct: 2987 TPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEAS-SSPTTAEGTGIPISTPSEGS 3045

Query: 1207 APCLCQDP--------QEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVS 1258
             P L   P         E S     P  S         V  +     GT+ P+ T    S
Sbjct: 3046 TP-LTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGS 3104

Query: 1259 LSPHSPLLSPKVASMDAKDLALQIL--PPCQVPPP-----SGPQSPAGPQGLSAPEQQED 1311
                +PL    V++      A+  L   P     P         SP   +G S P     
Sbjct: 3105 ----TPLTGVPVSTTPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPS 3160

Query: 1312 EDS 1314
            E S
Sbjct: 3161 EGS 3163



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 86/398 (21%), Positives = 130/398 (32%), Gaps = 65/398 (16%)

Query: 479  STATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEG------- 531
            ST  VT       P +     +     A E  +  T  + +  M M   S+         
Sbjct: 3761 STTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERSTLLTTVL 3820

Query: 532  ISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAE 591
            IS I       A  L TP  +TS  L   +     + G   +P+    +  +    R   
Sbjct: 3821 ISPISVMSPSEASTLSTPPGDTSTPLLTST-----KAGSFSIPAEVTTIRISITSERSTP 3875

Query: 592  -----EDLTLPQDS-----AMTPPLPLQ-----DTDLSSAPKPVAAATIVSQQAEEGLTL 636
                    TLP        A TPPL         TD +S P    A TI      EG T 
Sbjct: 3876 LTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVITEGST- 3934

Query: 637  PQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 696
            P  ++  P  P+  +     P    A +                  TP +    T+L++ 
Sbjct: 3935 PGTTIFIPSTPVTSSTADVFPATTGAVS------------------TPVIT--STELNT- 3973

Query: 697  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP---KPVAAATLVSQQAEEG 753
            P   +++T  S    +  T P   AMT   PL    +S+AP   +  +     S      
Sbjct: 3974 PSTSSSSTTTSFSTTKEFTTP---AMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSA 4030

Query: 754  LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDL 813
             + P  S      P+  +  SS P  + + TI         T P   + TPP     +  
Sbjct: 4031 TSTPHTSTSVTTRPVTPSSESSRPSTITSHTIPP-------TFPPAHSSTPP---TTSAS 4080

Query: 814  SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 851
            S+   P A  T+ ++      T    +  T  +P   T
Sbjct: 4081 STTVNPEAVTTMTTRTKPSTRTTSFPTVTTTAVPTNTT 4118


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 217/901 (24%), Positives = 316/901 (35%), Gaps = 180/901 (19%)

Query: 507  GEEETDSTAGQESAAMAMPQPSQEGISEIL---GQESVTAEKL---------PTPQEETS 554
            G + T + A     A+  P+P Q  +  ++   GQ  + ++           PTP     
Sbjct: 1213 GNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHHLISQPAHVALIQAVAPTPGPTPV 1272

Query: 555  LTLCPDSPQNLKEEGGLDLPSGRKPV--------AAATIVPRQAEEDLTLPQDSAMTPPL 606
              L   +P       GL LP     V            IV RQA  D        +TP  
Sbjct: 1273 SVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRD-------GLTPVP 1325

Query: 607  PLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTP---PLPLQDTELSSAPKPVAAA 663
            PL     + AP+P ++             L     +TP   P P   T  +  P P    
Sbjct: 1326 PL-----APAPRPPSSGLPA--------VLNPRPTLTPGRLPTPTLGTARAPMPTPTLVR 1372

Query: 664  TLV----SQQAEEGLTLPQDSAMTPPLPLQDTDL----SSAPKPVAAATLVSQQAEEGLT 715
             L+    S   E   + P  + +T   PL         +S+P P+  ++ ++      ++
Sbjct: 1373 PLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVS 1432

Query: 716  LPQDSAMTPPLPLQDTDLSSAPK--PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 773
            +P  S++   +P      +SAP   P++A   VS      LT     ++TPPL      +
Sbjct: 1433 VPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLT-----SVTPPLA---PVV 1484

Query: 774  SSAPKPVAAATIVSQQAEEGLTL------PQDSAMTP--PLPLQDTD-----LSSAPKPV 820
             +AP P + A   +  +   LTL         S+ TP  PL L  T      L+S   P 
Sbjct: 1485 PAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPA 1544

Query: 821  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA-ATPVSQQA--EEGLTLP 877
             +  LV   A   L  P  SA  P  P Q + L+ A     A ATP++  A  +  +  P
Sbjct: 1545 CSPVLVPASA---LASPFPSAPNPA-PAQASLLAPASSASQALATPLAPMAAPQTAILAP 1600

Query: 878  QDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRP 937
              +   APLP+    P + P   +  TP  + A     P + P  ++A      A  P  
Sbjct: 1601 SPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMA-----PSSTPGTSLASASPVPAPTPVL 1655

Query: 938  APEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGA 997
            AP      LP  P P+ L           A A  P         TL +         +  
Sbjct: 1656 APSSTQTMLPA-PVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGT------GNPQ 1708

Query: 998  GEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSAL 1057
            G    + LS     + +   A T   A P  P   T      Q   L P A    P S +
Sbjct: 1709 GPFPTQTLSLTPASSLVPTPAQTLSLA-PGPPLGPT------QTLSLAP-APPLAPASPV 1760

Query: 1058 GGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSV 1117
            G A   P       P  S A LL+PA  +  L+    P PTL  A A   +L        
Sbjct: 1761 GPA---PAHTLTLAPASSSASLLAPASVQT-LTLSPAPVPTLGPAAAQTLAL-------- 1808

Query: 1118 GAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQP 1177
                        APA T +P SQ    V+   S   P  V  V   P+       +K +P
Sbjct: 1809 ------------APASTQSPASQASSLVVS-ASGAAPLPVTMVSRLPV-------SKDEP 1848

Query: 1178 STPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQE----DSVEDE----------- 1222
             T   R   P P +  T  G   P  +PP P     P+     DS+E++           
Sbjct: 1849 DTLTLRSGPPSPPSTATSFGGPRPRRQPPPP-----PRSPFYLDSLEEKRKRQRSERLER 1903

Query: 1223 -----EPPGSLG------------LPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPL 1265
                 E  G+L             LP P A   P      G + P  T    + + H  +
Sbjct: 1904 IFQLSEAHGALAPVYGTEVLDFCTLPQPVAS--PIGPRSPGPSHP--TFWTYTEAAHRAV 1959

Query: 1266 LSPKVASMDAKDLA---LQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDS-PR 1321
            L P+       ++    + ++PP + PPPS       P    AP Q   ++ L  +  PR
Sbjct: 1960 LFPQQRLDQLSEIIERFIFVMPPVEAPPPS--LHACHPPPWLAPRQAAFQEQLASELWPR 2017

Query: 1322 A 1322
            A
Sbjct: 2018 A 2018



 Score = 87.0 bits (214), Expect = 1e-16
 Identities = 226/932 (24%), Positives = 327/932 (35%), Gaps = 168/932 (18%)

Query: 526  QPSQEGISEIL----GQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVA 581
            QP+   + ++L    G  S T+   PTP    +L+L P  P  ++      L     P +
Sbjct: 1076 QPNSGSLPQVLPSPLGVLSGTSRP-PTP----TLSLKPTPPAPVR------LSPAPPPGS 1124

Query: 582  AATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSV 641
            ++ + P       T P  +A T          ++ P P  A   +    +    LP   V
Sbjct: 1125 SSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEV 1184

Query: 642  MTPPLPLQDTELSS-APKPVAAA----TLVSQQAEEGLTLP----QDSAMTPPLPLQDTD 692
            ++        +L+S A +PVA A     L  Q     LTL     +  A+  P PLQ  +
Sbjct: 1185 VSIG------QLASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQ-RN 1237

Query: 693  LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTP-PLPLQDTDLSSAPKPVAAATLVSQQAE 751
            +           L+SQ A   + L Q  A TP P P+     SS P    A T       
Sbjct: 1238 VVHLVSAGGQHHLISQPAH--VALIQAVAPTPGPTPVSVLP-SSTPSTTPAPT------- 1287

Query: 752  EGLTLPQDSAMTPPLPLQDTDL-----SSAPK----PVAAATIVSQQAEEGL--TLPQDS 800
             GL+LP  +   PP  + +T +       AP+    PV       +    GL   L    
Sbjct: 1288 -GLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRP 1346

Query: 801  AMTP---PLPLQDTDLSSAPKPVAAATLV----SQQAEEGLTLPQDSAMTPPLPLQDTDL 853
             +TP   P P   T  +  P P     L+    S   E   + P  + +T   PL     
Sbjct: 1347 TLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSS 1406

Query: 854  ----SSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQ 909
                +S+P P+  ++P++      +++P  S++   +P     P S P  + ++ P T+ 
Sbjct: 1407 LPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVS 1466

Query: 910  AE---------------AGCAPGTEPVATMAQQEVGEA--LGPRPAPEEKNAALPTVP-- 950
            A                   APG   +A         A  LG   AP   ++  P  P  
Sbjct: 1467 ASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLL 1526

Query: 951  -------------------EPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLP 991
                                P  +       P P+A    P  A   A ++   +AL+ P
Sbjct: 1527 LAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATP 1586

Query: 992  EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEH 1051
                 A +    A S     A L   A    GA P     +T          +  +A   
Sbjct: 1587 LAPMAAPQTAILAPSPAPPLAPLPVLA-PSPGAAPVLASSQT---------PVPVMAPSS 1636

Query: 1052 GPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATE----- 1106
             P ++L  A  VP   P   P  +Q  L +P            P P LPS  +T+     
Sbjct: 1637 TPGTSLASASPVPAPTPVLAPSSTQTMLPAP-----------VPSP-LPSPASTQTLALA 1684

Query: 1107 -ASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPL 1165
             A   +   SS     SL  G P  P PT    S  P   L    V  P +  S+   P 
Sbjct: 1685 PALAPTLGGSSPSQTLSLGTGNPQGPFPTQT-LSLTPASSL----VPTPAQTLSLAPGPP 1739

Query: 1166 LQPPE--NLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEE 1223
            L P +  +LA   P  P   P+GP P+   TLA     P    A  L     +       
Sbjct: 1740 LGPTQTLSLAPAPPLAPAS-PVGPAPAHTLTLA-----PASSSASLLAPASVQTLTLSPA 1793

Query: 1224 PPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPR--VSLSPHSPL----LSPKVASMDAKD 1277
            P  +LG     A  Q  A A + T  P        VS S  +PL    +S    S D  D
Sbjct: 1794 PVPTLG----PAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPD 1849

Query: 1278 -LALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDE----DSLEEDSPRALGSG-----Q 1327
             L L+  PP    PPS   S  GP+    P          DSLEE   R          Q
Sbjct: 1850 TLTLRSGPP---SPPSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQ 1906

Query: 1328 HSDSHGESSAELDEQDILAPQTVQCPAQAPAG 1359
             S++HG + A +   ++L   T+  P  +P G
Sbjct: 1907 LSEAHG-ALAPVYGTEVLDFCTLPQPVASPIG 1937



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 185/861 (21%), Positives = 286/861 (33%), Gaps = 117/861 (13%)

Query: 499  ATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLC 558
            A +V   A   E D     E      P    E +S    + +   E+L TP E  ++   
Sbjct: 2262 AEQVAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQL-TPIERYAMKFL 2320

Query: 559  PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDL-TLPQDSAMTPPLPLQDT------ 611
              S + +  E   +L    + V AA     QA+E++  LPQ+    P    + +      
Sbjct: 2321 EASLEEVSRE---ELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGG 2377

Query: 612  ---DLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQ 668
                   A  P    T VS++        Q +  TP +    T  ++ P   + A     
Sbjct: 2378 THRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARE--- 2434

Query: 669  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLT-LPQDSAMTPPLP 727
                   +P+ +    P P        A  PV  +  V   A   +T LP     +PP P
Sbjct: 2435 ------RVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPP 2488

Query: 728  LQDTDLSS-APKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 786
             Q    SS A  P  A T                A TPP         S+P  +   ++ 
Sbjct: 2489 SQIPPCSSPACTPPPACT-------------PPPAHTPPPAQTCLVTPSSPLLLGPPSVP 2535

Query: 787  SQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQD--SAMTP 844
               +   L L     + P   L    L+S      A+   S+ +   L  P+D       
Sbjct: 2536 ISASVTNLPL----GLRPEAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVE 2591

Query: 845  PLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPE----PL 900
             LP+ + +LS  P   +          E  ++P      AP   + T  T  PE    PL
Sbjct: 2592 ILPVSEKNLSLTPSAPSLTL-------EAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPL 2644

Query: 901  AVATPQTLQAEAGCA---PGTEPV-ATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALD 956
             V+    L+     A   P  EP+ A    +E+ EA  P  +PE+    +       +  
Sbjct: 2645 CVSESNGLELPPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTS 2704

Query: 957  QVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEA 1016
                  P+  + A  P   +    + + +       P    G ++   L  PGR   +  
Sbjct: 2705 SSATSSPEGPSPARPP---RRRTSADVEIRGQGTGRPGQPPGPKVLRKL--PGRLVTVVE 2759

Query: 1017 RAHTGDGAKPDSPQKETLEV---ENQQEGGLKPLAQEHGPRSA--LGGAREVPDAPPAAC 1071
                    +       TL     E     G   +    GP S+  +GG  E   AP ++ 
Sbjct: 2760 EKELVRRRRQQRGAASTLVPGVSETSASPGSPSVRSMSGPESSPPIGGPCEA--APSSSL 2817

Query: 1072 PEVSQARLLSPAREERGLSGKSTPE-------PTLPSAVATEASLDSCPESSVGAVSSLD 1124
            P   Q   ++    E G++G  +PE          P AV         P     + +   
Sbjct: 2818 PTPPQQPFIARRHIELGVTGGGSPENGDGALLAITPPAVKRRRGR---PPKKNRSPADAG 2874

Query: 1125 RGCPDAPAPTSAPTSQQPEPVLG------LGSVEQPHEVPSV--LG-------TPLLQPP 1169
            RG  +AP+ T    +   +PV G         V +P  +P    LG        PLL P 
Sbjct: 2875 RGVDEAPSSTLKGKTNGADPVPGPETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPV 2934

Query: 1170 ENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLG 1229
            E   +G+P    D P+      PGT++ A                 E   +    P  L 
Sbjct: 2935 EKRRRGRPPKARDLPI------PGTISSAG------------DGNSESRTQPPPHPSPLT 2976

Query: 1230 LPPPQAGVQPAAAAVSGTTQPLGTGP--RVSLSPHSPLLSPKVASMDAKDL-ALQILPPC 1286
              PP      A  A + TT  + T P  R    P     SP+ + +   D  +  +L  C
Sbjct: 2977 PLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNPPSPRPSQLPVLDRDSTSVLESC 3036

Query: 1287 QVPPPSGPQSPAGPQGLSAPE 1307
             +     PQ     +G S+ E
Sbjct: 3037 GLGRRRQPQGQGESEGSSSDE 3057



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 113/481 (23%), Positives = 173/481 (35%), Gaps = 79/481 (16%)

Query: 911  EAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAG 970
            EAG     +   + A+QE+  AL  +  P E+ A        A+L++V +++ + A E  
Sbjct: 2284 EAGRPGAEDEEMSRAEQEIA-ALVEQLTPIERYAMKFL---EASLEEVSREELKQAEEQV 2339

Query: 971  TPWAAQEDADSTLGMEALSLP---EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPD 1027
               AA++D D     E   LP   E   GAG+E               +   TG G    
Sbjct: 2340 E--AARKDLDQAKE-EVFRLPQEEEEGPGAGDE---------------SSCGTGGGT--- 2378

Query: 1028 SPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREER 1087
               + + + +  +  G +   +  G R+   GA   P          +     SPARE R
Sbjct: 2379 --HRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARE-R 2435

Query: 1088 GLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLD-------RGCPDAPAPTSAPTSQ 1140
                   P PT  SA A   +L   P S+   +S+ +          P  P P+  P   
Sbjct: 2436 VPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCS 2495

Query: 1141 QPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPV-----DRPLGPDPSAPGTL 1195
             P           P   P    T L+ P   L  G PS P+     + PLG  P A    
Sbjct: 2496 SPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAELCA 2555

Query: 1196 AGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGP 1255
               A P          +  +  SV   E   SL L PP+  + P A  +   ++      
Sbjct: 2556 QALASP----------ESLELASVASSE-TSSLSLVPPK-DLLPVAVEILPVSE-----K 2598

Query: 1256 RVSLSPHSPLLSPKVASM----------DAKDLALQILPPCQVPPPSGPQSPAGPQGLSA 1305
             +SL+P +P L+ +  S+           A+   L +LP  +  P    +S     GL  
Sbjct: 2599 NLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSES----NGLEL 2654

Query: 1306 PEQQEDEDSLEED-----SPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGG 1360
            P     ++ L+E      +   L   +   S  E   EL   ++ AP T      +P G 
Sbjct: 2655 PPSAASDEPLQEPLEADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGP 2714

Query: 1361 S 1361
            S
Sbjct: 2715 S 2715



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 182/895 (20%), Positives = 284/895 (31%), Gaps = 193/895 (21%)

Query: 606  LPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATL 665
            +PL++   SS P          ++ EE +   Q  ++   L   + E        A A  
Sbjct: 2212 MPLEEPSSSSVPS-------APEEEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQ 2264

Query: 666  VSQQAE--EGLTLPQDSAMTPPLP-LQDTDLSSAPKPVAAA----TLVSQQAEEGLTLPQ 718
            V++ AE  E    P         P  +D ++S A + +AA     T + + A + L    
Sbjct: 2265 VAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFLEASL 2324

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT------- 771
            +      L   +  + +A K +       Q  EE   LPQ+    P    + +       
Sbjct: 2325 EEVSREELKQAEEQVEAARKDL------DQAKEEVFRLPQEEEEGPGAGDESSCGTGGGT 2378

Query: 772  --DLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQ 829
                  A  P    T VS++        Q +  TP +    T  ++ P   + A      
Sbjct: 2379 HRRSKKAKAPERPGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARE---- 2434

Query: 830  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQ 889
                  +P+ +    P P        A  PV  + PV   A   +T+     + +P P  
Sbjct: 2435 -----RVPRPAPRPRPTPASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPS 2489

Query: 890  DTGPTSGPE---------------------------------------------PLAVAT 904
               P S P                                              PL +  
Sbjct: 2490 QIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRP 2549

Query: 905  PQTLQAEAGCAPGTEPVATMAQQEVGE------------ALGPRPAPEEKNAALPTVP-- 950
               L A+A  +P +  +A++A  E               A+   P  E+  +  P+ P  
Sbjct: 2550 EAELCAQALASPESLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLTPSAPSL 2609

Query: 951  --EPAALDQVQQDDPQPAAEAGTPWAAQEDAD---------------STLGMEALSLPEP 993
              E  ++   Q+ +   +AE  T     E  +               S    E L  P  
Sbjct: 2610 TLEAGSIPNGQEQEAPDSAEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPLE 2669

Query: 994  ASGAGEEIAEALS------RPGREACLEARAHTGDGAKPDSPQ----------KETLEVE 1037
            A    EE+ EA +      +P      E  A +   +   SP+          + + +VE
Sbjct: 2670 ADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADVE 2729

Query: 1038 NQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEP 1097
             + +G  +P  Q  GP       + +   P      V +  L+   R++RG +    P  
Sbjct: 2730 IRGQGTGRP-GQPPGP-------KVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPGV 2781

Query: 1098 TLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEP----------VLG 1147
            +  SA     S+     S  G  SS   G P   AP+S+  +   +P          V G
Sbjct: 2782 SETSASPGSPSV----RSMSGPESSPPIGGPCEAAPSSSLPTPPQQPFIARRHIELGVTG 2837

Query: 1148 LGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAG---------- 1197
             GS E        +  P ++        +  +P D   G D +   TL G          
Sbjct: 2838 GGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSSTLKGKTNGADPVPG 2897

Query: 1198 -----AALPPLEP----------PAPCLCQDPQEDSVEDE---EPPGSLGLPPPQAGVQP 1239
                  A P LEP          P P    +P    VE      PP +  LP P      
Sbjct: 2898 PETLIVADPVLEPQLIPGPQPLGPQPVHRPNPLLSPVEKRRRGRPPKARDLPIPGTISSA 2957

Query: 1240 AAAAVSGTTQPLGTGPRVS-LSPHSPLLSPKVASM--DAKDLALQILPPCQV--PPPSGP 1294
                    TQP    P  S L+P  PLL    A++      + +   PP +    PP  P
Sbjct: 2958 GDGNSESRTQP---PPHPSPLTPLPPLLVCPTATVANTVTTVTISTSPPKRKRGRPPKNP 3014

Query: 1295 QSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQT 1349
             SP   Q    P    D  S+ E     LG  +     GES     ++D   P T
Sbjct: 3015 PSPRPSQ---LPVLDRDSTSVLESC--GLGRRRQPQGQGESEGSSSDEDGSRPLT 3064



 Score = 45.8 bits (107), Expect = 3e-04
 Identities = 82/302 (27%), Positives = 113/302 (37%), Gaps = 58/302 (19%)

Query: 13   PEADRPGP-RTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGAS 71
            P A  P P +  L   A++A+  L      P A    P    L   P+ P A P P  A 
Sbjct: 1560 PSAPNPAPAQASLLAPASSASQALA----TPLAPMAAPQTAILAPSPAPPLA-PLPVLAP 1614

Query: 72   WDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALL- 130
                PG AP   +      P P++ P      +L++ +P+PA   P  V+   + Q +L 
Sbjct: 1615 ---SPGAAPVLASSQT---PVPVMAPSSTPGTSLASASPVPA---PTPVLAPSSTQTMLP 1665

Query: 131  --------SPRAART-----ALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPP 177
                    SP + +T     AL    GG +    P +  S G  +   P P      TP 
Sbjct: 1666 APVPSPLPSPASTQTLALAPALAPTLGGSS----PSQTLSLGTGNPQGPFPTQTLSLTPA 1721

Query: 178  S----TPTKT-TYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSP 232
            S    TP +T + A  P  GP              L  +PP +P+     A   +   +P
Sbjct: 1722 SSLVPTPAQTLSLAPGPPLGPTQTL---------SLAPAPPLAPASPVGPAPAHTLTLAP 1772

Query: 233  -SCSLSLLAPAEGLDFPSGWGLSPQ------GSMVDERELHPAGTPEPPSSESSLSADSS 285
             S S SLLAPA          LSP        +      L PA T  P S  SSL   +S
Sbjct: 1773 ASSSASLLAPASVQTLT----LSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSAS 1828

Query: 286  SS 287
             +
Sbjct: 1829 GA 1830



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 61/262 (23%), Positives = 100/262 (38%), Gaps = 47/262 (17%)

Query: 198 RDSEAELRDELLDSPP------ASPSGSYITADGDSWASSPSCSLSLLAPAEGLDF--PS 249
           R+ E  L + L   PP      +SPS +  + D D+             P EG +   P 
Sbjct: 326 REGELPLEELLRSLPPQLLEGPSSPSQTPSSHDSDTRDG----------PEEGAEEEPPQ 375

Query: 250 GWGLSPQGSMVDERELHP-----------AGTPEPPSSESSLSADSSSSWGQEGHFFDLD 298
              + P  S V +R   P           A   E    E +++A+     G+  H  +L 
Sbjct: 376 VLEIKPPPSAVTQRNKQPWHPDEDDEEFTANEEEAEDEEDTIAAEEQLE-GEVDHAMELS 434

Query: 299 FLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAV----ADPDPGGDLAGEGEE 354
            LA +       L  +  L     A      S E+E+E+ V    +D +P G +  E   
Sbjct: 435 ELARE-----GELSMEELLQQYAGAYAPGSGSSEDEDEDEVDANSSDCEPEGPVEAEEPP 489

Query: 355 DSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDS------DSASYAEADDERLYSGE 408
              S+S   S+ D S  E  + +       S+AS +S      D+ S ++AD+E     +
Sbjct: 490 QEDSSSQSDSVEDRSEDEEDEHSEEEETSGSSASEESESEESEDAQSQSQADEEE--EDD 547

Query: 409 PHAQATLLQDSVQKTEEESGGG 430
                 LL    +++E ++G G
Sbjct: 548 DFGVEYLLARDEEQSEADAGSG 569



 Score = 36.2 bits (82), Expect = 0.25
 Identities = 167/729 (22%), Positives = 234/729 (32%), Gaps = 128/729 (17%)

Query: 44   ALTPGPSHLALTFLPSK-PGARPQPEGASWDAGPGGAPSAWAD------------PGEG- 89
            A TPGP+ +++  LPS  P   P P G S        P    +            P +G 
Sbjct: 1264 APTPGPTPVSV--LPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGL 1321

Query: 90   GPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGE-----ETCQALLSPRAARTALRDQEG 144
             P P L P           + LPA L PR  +        T     +P    T +R    
Sbjct: 1322 TPVPPLAPA-----PRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLK 1376

Query: 145  GHASPDPPPELCSQG--DLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEA 202
               SP P     + G   L++ SP   P S   P S+P       +P   P      S  
Sbjct: 1377 LVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMP-----IPNSSPLASPVSSTV 1431

Query: 203  ELR---------DELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGL--DFPSGW 251
             +             L +P ++P    I+A     AS P+   S+  P   +    P   
Sbjct: 1432 SVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPP 1491

Query: 252  GLSPQGSMVDERELHPAGTPEPPSSESS-------LSADSSSSWGQEGHFFDLDFLANDP 304
             L+P G+      L   G    PS  SS       L A +SS     G    +    +  
Sbjct: 1492 SLAPSGASPSASAL-TLGLATAPSLSSSQTPGHPLLLAPTSSH--VPGLNSTVAPACSPV 1548

Query: 305  MIPAALL-----------PFQGSLIFQVEAVE---VTPLSPEEEEEEAVADPDPGGDLAG 350
            ++PA+ L           P Q SL+    +      TPL+P    + A+  P P   LA 
Sbjct: 1549 LVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLA- 1607

Query: 351  EGEEDSTSASFLQSLSDLSITEGMDEAFAFRDD--TSAASSDSDSASYAEADDERLYSGE 408
                          L  L+ + G     A         A S +   S A A      S  
Sbjct: 1608 -------------PLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASA------SPV 1648

Query: 409  PHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL---- 464
            P     L   S Q              A   T++ A   AP     G+  SQ   L    
Sbjct: 1649 PAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLG--GSSPSQTLSLGTGN 1706

Query: 465  -ISEVTEEGLALGQESTATVTP-HTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAM 522
                   + L+L   S+   TP  TL +APG          P  G  +T S A     A 
Sbjct: 1707 PQGPFPTQTLSLTPASSLVPTPAQTLSLAPG----------PPLGPTQTLSLAPAPPLAP 1756

Query: 523  AMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDL----PSGRK 578
            A P       +  L   S +A  L  P    +LTL P     L       L     S + 
Sbjct: 1757 ASPVGPAPAHTLTLAPASSSASLL-APASVQTLTLSPAPVPTLGPAAAQTLALAPASTQS 1815

Query: 579  PVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDL----SSAPKPVAAATIVSQQAEEGL 634
            P + A+ +   A     LP       P+   + D     S  P P + AT          
Sbjct: 1816 PASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGG------ 1869

Query: 635  TLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQ-DSAMTPPLPLQDTDL 693
              P+     PP P     L S  +        S++ E    L +   A+ P    +  D 
Sbjct: 1870 --PRPRRQPPPPPRSPFYLDSLEEKRKRQR--SERLERIFQLSEAHGALAPVYGTEVLDF 1925

Query: 694  SSAPKPVAA 702
             + P+PVA+
Sbjct: 1926 CTLPQPVAS 1934



 Score = 33.1 bits (74), Expect = 2.1
 Identities = 44/168 (26%), Positives = 58/168 (34%), Gaps = 26/168 (15%)

Query: 1184 PLGPDPSAPGTLAGAALPPLEPPAPCL--------CQDPQEDSVEDEEPPGSLGLPP--P 1233
            PLGP P  P      +  P   P P +                +    PPG + LPP  P
Sbjct: 1018 PLGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQP 1077

Query: 1234 QAGVQPAA-----AAVSGTTQPLGTGPRVSLSPHSPL---LSPKVASMDAKDLALQILPP 1285
             +G  P         +SGT++P    P +SL P  P    LSP      +  L    +PP
Sbjct: 1078 NSGSLPQVLPSPLGVLSGTSRP--PTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTVPP 1135

Query: 1286 CQVPPP------SGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQ 1327
                PP      S   + A    + AP        L  D    L SG+
Sbjct: 1136 GYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGE 1183



 Score = 31.6 bits (70), Expect = 6.1
 Identities = 63/263 (23%), Positives = 83/263 (31%), Gaps = 57/263 (21%)

Query: 90   GPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASP 149
            GP P+  P G    A  T  P+P  L   +++        L P              AS 
Sbjct: 1020 GPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIP--------------ASR 1065

Query: 150  DPPPEL---CSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRD 206
             P P L         S+P   P P    +  S P   T +L P   P    R S      
Sbjct: 1066 PPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPT--PPAPVRLS------ 1117

Query: 207  ELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELH 266
                  PA P G                S SLL P   L  P G+   P  +        
Sbjct: 1118 ------PAPPPG----------------SSSLLKP---LTVPPGYTFPPAAATTTSTTTA 1152

Query: 267  PAGT-----PEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQV 321
             A T     P P      LS D  +     G    +  LA+    P A       L FQ+
Sbjct: 1153 TATTTAVPAPTPAPQRLILSPDMQARL-PSGEVVSIGQLASLAQRPVANAGGSKPLTFQI 1211

Query: 322  EAVEVTPLSPEEEEEEAVADPDP 344
            +  ++T L+  +  + AV  P P
Sbjct: 1212 QGNKLT-LTGAQVRQLAVGQPRP 1233


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 197/908 (21%), Positives = 310/908 (34%), Gaps = 130/908 (14%)

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPD 560
            +  P +G  +T  +  + S       P+++   +++  E +T E   +  +E+S +    
Sbjct: 77   KAPPPSGASQTIKSTTKRSPK----PPNKKKTKKVIESEEITEEHSVSENQESSSSSSSS 132

Query: 561  SPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPV 620
            S                   +++TI  R+ +       +  +   L ++D   +   K  
Sbjct: 133  S-------------------SSSTI--RKIKSSKNSAANRELQKKLKVKDNKKNRTKKKP 171

Query: 621  AAATIVSQQAEEGLTLPQDSVMTPPLPL-QDTELSSAPKPVAAATLVSQQA--------- 670
                 V  +A  GL      V TP     Q  ++S++PK   A  +  + +         
Sbjct: 172  TPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSK 231

Query: 671  EEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 729
            E  LT+ +++ + T      +   S+  K    +   +Q  E+  T  +D A T  +  +
Sbjct: 232  ETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK--TSAKDLAPTSKVLAK 289

Query: 730  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK------PVAAA 783
             T  +       A T   +      T P++ A T P     T + SAP       P    
Sbjct: 290  PTPKAETTTKGPALTTPKEPTP---TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK 346

Query: 784  TIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMT 843
            +  +   E   T  ++ A T P     T  +  P P    +  +   E   T P+  A T
Sbjct: 347  SAPTTPKEPAPTTTKEPAPTTPKEPAPTT-TKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 405

Query: 844  PPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVA 903
             P     T     P P     P     E   T P++ A TAP   +   PT+  EP A  
Sbjct: 406  TPKEPAPTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEP-APT 460

Query: 904  TPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALD----QVQ 959
            TP+            EP  T   +E        PAP    +A  T  EPA          
Sbjct: 461  TPK------------EPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 507

Query: 960  QDDPQP-AAEAGTPWAAQEDADSTLGMEALSLP-EPASGAGEEIAEALS-RPGREACLEA 1016
              +P P   +   P   +E A +T    A + P EPA    +E A   + +P      E 
Sbjct: 508  PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 567

Query: 1017 RAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQ 1076
               T     P +P+K T                   P +    A   P+ P    PE   
Sbjct: 568  APTTPKETAPTTPKKLT-------------------PTTPEKLAPTTPEKPAPTTPE--- 605

Query: 1077 ARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSA 1136
              L     EE   +    P PT P A A     +  P +      +     P  PAPT+ 
Sbjct: 606  -ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT----TPKEPAPTT- 659

Query: 1137 PTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLA----KGQPSTPVDRPLGPDPSAP 1192
            P    P    G          P+   TP    P+ LA    K   ST  D+P      AP
Sbjct: 660  PKETAPTTPKGTAPTTLKEPAPT---TPKKPAPKELAPTTTKEPTSTTCDKP------AP 710

Query: 1193 GTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLG 1252
             T  G A    + PAP   ++P   + +   P  +L  P P    +PA   ++ TT    
Sbjct: 711  TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT-TLKEPAPTTPKKPAPKELAPTTT--- 766

Query: 1253 TGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDE 1312
             GP  + S      +PK  +           P  + P P+ P++P       +      E
Sbjct: 767  KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP--KKPAPTTPETPPPTTSEVSTPTTTKE 824

Query: 1313 DSLEEDSPRALGSGQHSDSHGESSAELDEQDI-LAPQTVQCP-AQAPAGGSEETIAKAKQ 1370
             +    SP         +S  E SAE   + +  +P+    P  + PA    E    AK 
Sbjct: 825  PTTIHKSP--------DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD 876

Query: 1371 SRSEKKAR 1378
              +E+  R
Sbjct: 877  KTTERDLR 884



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 108/516 (20%), Positives = 161/516 (31%), Gaps = 59/516 (11%)

Query: 446 EAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQ 505
           E AP T    A  + ++   +   E      +E   T T       P       T+  P 
Sbjct: 432 EPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 491

Query: 506 AGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNL 565
             +E   +T          P P+             T E  PT  +E + T         
Sbjct: 492 TTKEPAPTTTKSAPTTPKEPSPT------------TTKEPAPTTPKEPAPTTPKKPAPTT 539

Query: 566 KEEGGLDLPSGRKPVAAATIVPRQAEEDL-TLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 624
            +E     P    P       P   +E   T P+++A T P  L  T             
Sbjct: 540 PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 599

Query: 625 IVSQQAEEGLTLPQDSV-MTPPLPLQDTELSSAPKPVA--AATLVSQQA-----EEGLTL 676
             +   E   T P++    TP  P   T  ++AP      A T   + A     E   T 
Sbjct: 600 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 659

Query: 677 PQDSAMTPPL---------PLQDTDLSSAPKPVAAATLVSQQA----EEGLTLPQDSAMT 723
           P+++A T P          P   T    APK +A  T     +    +   T P+ +A T
Sbjct: 660 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 719

Query: 724 PPL---------PLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 774
            P          P   T   +AP  +      + +      L   +   P     D    
Sbjct: 720 TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 779

Query: 775 SAPKPVAAATIVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEG 833
           + PK  A  T      E   T P+  A  TP  P   T   S P      T + +  +E 
Sbjct: 780 TTPKETAPTT----PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE- 834

Query: 834 LTLPQDSAMTPPLPLQD---------TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA 884
            + P+ SA   P  L++         T   +A KP    T   +  E  L    ++   A
Sbjct: 835 -STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 893

Query: 885 PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920
           P   ++T  T+     +  T  T Q  +     T P
Sbjct: 894 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 929


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 197/908 (21%), Positives = 310/908 (34%), Gaps = 130/908 (14%)

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPD 560
            +  P +G  +T  +  + S       P+++   +++  E +T E   +  +E+S +    
Sbjct: 118  KAPPPSGASQTIKSTTKRSPK----PPNKKKTKKVIESEEITEEHSVSENQESSSSSSSS 173

Query: 561  SPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPV 620
            S                   +++TI  R+ +       +  +   L ++D   +   K  
Sbjct: 174  S-------------------SSSTI--RKIKSSKNSAANRELQKKLKVKDNKKNRTKKKP 212

Query: 621  AAATIVSQQAEEGLTLPQDSVMTPPLPL-QDTELSSAPKPVAAATLVSQQA--------- 670
                 V  +A  GL      V TP     Q  ++S++PK   A  +  + +         
Sbjct: 213  TPKPPVVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRPSLPPNSDTSK 272

Query: 671  EEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 729
            E  LT+ +++ + T      +   S+  K    +   +Q  E+  T  +D A T  +  +
Sbjct: 273  ETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK--TSAKDLAPTSKVLAK 330

Query: 730  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK------PVAAA 783
             T  +       A T   +      T P++ A T P     T + SAP       P    
Sbjct: 331  PTPKAETTTKGPALTTPKEPTP---TTPKEPASTTPKEPTPTTIKSAPTTPKEPAPTTTK 387

Query: 784  TIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMT 843
            +  +   E   T  ++ A T P     T  +  P P    +  +   E   T P+  A T
Sbjct: 388  SAPTTPKEPAPTTTKEPAPTTPKEPAPTT-TKEPAPTTTKSAPTTPKEPAPTTPKKPAPT 446

Query: 844  PPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVA 903
             P     T     P P     P     E   T P++ A TAP   +   PT+  EP A  
Sbjct: 447  TPKEPAPTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAPTTPKEP-APT 501

Query: 904  TPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALD----QVQ 959
            TP+            EP  T   +E        PAP    +A  T  EPA          
Sbjct: 502  TPK------------EPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTT 548

Query: 960  QDDPQP-AAEAGTPWAAQEDADSTLGMEALSLP-EPASGAGEEIAEALS-RPGREACLEA 1016
              +P P   +   P   +E A +T    A + P EPA    +E A   + +P      E 
Sbjct: 549  PKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEP 608

Query: 1017 RAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQ 1076
               T     P +P+K T                   P +    A   P+ P    PE   
Sbjct: 609  APTTPKETAPTTPKKLT-------------------PTTPEKLAPTTPEKPAPTTPE--- 646

Query: 1077 ARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSA 1136
              L     EE   +    P PT P A A     +  P +      +     P  PAPT+ 
Sbjct: 647  -ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT----TPKEPAPTT- 700

Query: 1137 PTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLA----KGQPSTPVDRPLGPDPSAP 1192
            P    P    G          P+   TP    P+ LA    K   ST  D+P      AP
Sbjct: 701  PKETAPTTPKGTAPTTLKEPAPT---TPKKPAPKELAPTTTKEPTSTTCDKP------AP 751

Query: 1193 GTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLG 1252
             T  G A    + PAP   ++P   + +   P  +L  P P    +PA   ++ TT    
Sbjct: 752  TTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT-TLKEPAPTTPKKPAPKELAPTTT--- 807

Query: 1253 TGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDE 1312
             GP  + S      +PK  +           P  + P P+ P++P       +      E
Sbjct: 808  KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP--KKPAPTTPETPPPTTSEVSTPTTTKE 865

Query: 1313 DSLEEDSPRALGSGQHSDSHGESSAELDEQDI-LAPQTVQCP-AQAPAGGSEETIAKAKQ 1370
             +    SP         +S  E SAE   + +  +P+    P  + PA    E    AK 
Sbjct: 866  PTTIHKSP--------DESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKD 917

Query: 1371 SRSEKKAR 1378
              +E+  R
Sbjct: 918  KTTERDLR 925



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 108/516 (20%), Positives = 161/516 (31%), Gaps = 59/516 (11%)

Query: 446 EAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQ 505
           E AP T    A  + ++   +   E      +E   T T       P       T+  P 
Sbjct: 473 EPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 532

Query: 506 AGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNL 565
             +E   +T          P P+             T E  PT  +E + T         
Sbjct: 533 TTKEPAPTTTKSAPTTPKEPSPT------------TTKEPAPTTPKEPAPTTPKKPAPTT 580

Query: 566 KEEGGLDLPSGRKPVAAATIVPRQAEEDL-TLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 624
            +E     P    P       P   +E   T P+++A T P  L  T             
Sbjct: 581 PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 640

Query: 625 IVSQQAEEGLTLPQDSV-MTPPLPLQDTELSSAPKPVA--AATLVSQQA-----EEGLTL 676
             +   E   T P++    TP  P   T  ++AP      A T   + A     E   T 
Sbjct: 641 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 700

Query: 677 PQDSAMTPPL---------PLQDTDLSSAPKPVAAATLVSQQA----EEGLTLPQDSAMT 723
           P+++A T P          P   T    APK +A  T     +    +   T P+ +A T
Sbjct: 701 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 760

Query: 724 PPL---------PLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 774
            P          P   T   +AP  +      + +      L   +   P     D    
Sbjct: 761 TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 820

Query: 775 SAPKPVAAATIVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEG 833
           + PK  A  T      E   T P+  A  TP  P   T   S P      T + +  +E 
Sbjct: 821 TTPKETAPTT----PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE- 875

Query: 834 LTLPQDSAMTPPLPLQD---------TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA 884
            + P+ SA   P  L++         T   +A KP    T   +  E  L    ++   A
Sbjct: 876 -STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 934

Query: 885 PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920
           P   ++T  T+     +  T  T Q  +     T P
Sbjct: 935 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 970


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 87.4 bits (215), Expect = 9e-17
 Identities = 184/798 (23%), Positives = 271/798 (33%), Gaps = 110/798 (13%)

Query: 611  TDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPL-QDTELSSAPKPVAAATLVSQQ 669
            T     PKP      V  +A  GL      V TP     Q  ++S++PK   A  +  + 
Sbjct: 74   TKKKPTPKPP-----VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRP 128

Query: 670  A---------EEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQD 719
            +         E  LT+ +++ + T      +   S+  K    +   +Q  E+  T  +D
Sbjct: 129  SLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK--TSAKD 186

Query: 720  SAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK- 778
             A T  +  + T  +       A T   +      T P++ A T P     T + SAP  
Sbjct: 187  LAPTSKVLAKPTPKAETTTKGPALTTPKEPTP---TTPKEPASTTPKEPTPTTIKSAPTT 243

Query: 779  -----PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEG 833
                 P    +  +   E   T  ++ A T P     T  +  P P    +  +   E  
Sbjct: 244  PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT-TKEPAPTTTKSAPTTPKEPA 302

Query: 834  LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGP 893
             T P+  A T P     T     P P     P     E   T P++ A TAP   +   P
Sbjct: 303  PTTPKKPAPTTPKEPAPTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAP 358

Query: 894  TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPA 953
            T+  EP A  TP+            EP  T   +E        PAP    +A  T  EPA
Sbjct: 359  TTPKEP-APTTPK------------EPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPA 404

Query: 954  ALD----QVQQDDPQP-AAEAGTPWAAQEDADSTLGMEALSLP-EPASGAGEEIAEALS- 1006
                        +P P   +   P   +E A +T    A + P EPA    +E A   + 
Sbjct: 405  PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK 464

Query: 1007 RPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDA 1066
            +P      E    T     P +P+K T                   P +    A   P+ 
Sbjct: 465  KPAPTTPKEPAPTTPKETAPTTPKKLT-------------------PTTPEKLAPTTPEK 505

Query: 1067 PPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRG 1126
            P    PE     L     EE   +    P PT P A A     +  P +      +    
Sbjct: 506  PAPTTPE----ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT---- 557

Query: 1127 CPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLA----KGQPSTPVD 1182
             P  PAPT+ P    P    G          P+   TP    P+ LA    K   ST  D
Sbjct: 558  TPKEPAPTT-PKETAPTTPKGTAPTTLKEPAPT---TPKKPAPKELAPTTTKEPTSTTCD 613

Query: 1183 RPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAA 1242
            +P      AP T  G A    + PAP   ++P   + +   P  +L  P P    +PA  
Sbjct: 614  KP------APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT-TLKEPAPTTPKKPAPK 666

Query: 1243 AVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQG 1302
             ++ TT     GP  + S      +PK  +           P  + P P+ P++P     
Sbjct: 667  ELAPTTT---KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP--KKPAPTTPETPPPTTS 721

Query: 1303 LSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDI-LAPQTVQCP-AQAPAGG 1360
              +      E +    SP         +S  E SAE   + +  +P+    P  + PA  
Sbjct: 722  EVSTPTTTKEPTTIHKSP--------DESTPELSAEPTPKALENSPKEPGVPTTKTPAAT 773

Query: 1361 SEETIAKAKQSRSEKKAR 1378
              E    AK   +E+  R
Sbjct: 774  KPEMTTTAKDKTTERDLR 791



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 171/811 (21%), Positives = 269/811 (33%), Gaps = 99/811 (12%)

Query: 484  TPHTLQVAPGLQVEVATRVTPQAGE--EETDSTAGQESAAMAMPQPSQEGISEILGQESV 541
            TP T++ AP    E A   T  A    +E   T  +E A     +P+     E       
Sbjct: 233  TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE---PAPT 289

Query: 542  TAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSA 601
            T +  PT  +E + T          +E     P    P       P   E   T P++ A
Sbjct: 290  TTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 349

Query: 602  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVA 661
             T P            KP  A T   + A      P  +    P P    E    P P  
Sbjct: 350  PTAP-----------KKP--APTTPKEPAPTTPKEPAPTTTKEPSPTTPKE----PAPTT 392

Query: 662  AATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSA 721
              +  +   E   T  + +  TP  P   T    AP         + +     T  + + 
Sbjct: 393  TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 452

Query: 722  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 781
             TP  P   T    AP         +   E   T P+++A T P  L  T     P+ +A
Sbjct: 453  TTPKEPAPTTTKKPAP---------TTPKEPAPTTPKETAPTTPKKLTPT----TPEKLA 499

Query: 782  AATIVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAP-KPVAAATLVSQQAEEGLTLPQD 839
              T      +   T P++ A  TP  P   T    AP  P AAA   +   E   T P++
Sbjct: 500  PTT----PEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKE 553

Query: 840  SAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEP 899
             A T P     T     PK  A  TP                 TAP  L++  PT+  +P
Sbjct: 554  PAPTTPKEPAPT----TPKETAPTTPKG---------------TAPTTLKEPAPTTPKKP 594

Query: 900  LAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQ 959
                   T   E       +P  T   +         PAP       PT P+  A   ++
Sbjct: 595  APKELAPTTTKEPTSTTCDKPAPT-TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK 653

Query: 960  QDDP----QPAAEAGTPWAAQEDADSTLGMEALSLP-EPASGAGEEIAEALSRPGREACL 1014
            +  P    +PA +   P   +    +T    A + P E A    +E A    +       
Sbjct: 654  EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP 713

Query: 1015 EARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEV 1074
            E    T       +  KE   +    +     L+ E  P+ AL  + + P  P    P  
Sbjct: 714  ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK-ALENSPKEPGVPTTKTPAA 772

Query: 1075 SQARLLSPARE---ERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1131
            ++  + + A++   ER L  ++TPE T  +   T+ +  +  +++   +++         
Sbjct: 773  TKPEMTTTAKDKTTERDL--RTTPETTTAAPKMTKETATTTEKTTESKITA-------TT 823

Query: 1132 APTSAPTSQQPEP--VLGLGSVEQPHEV----PSVLGTPLLQPPENLAKGQPSTPVDRPL 1185
               ++ T+Q   P  +  L +     +V     ++  T ++  PE  AK +      +  
Sbjct: 824  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 883

Query: 1186 GPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1245
             P P           P   P  P   + P+  ++     P +   P       P     S
Sbjct: 884  TPKPQK---------PTKAPKKPTSTKKPK--TMPRVRKPKTTPTPRKMTSTMPELNPTS 932

Query: 1246 GTTQP-LGTGPRVSLSPHSPLLSPKVASMDA 1275
               +  L T  R + +P+S L+     S DA
Sbjct: 933  RIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 963



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 136/573 (23%), Positives = 193/573 (33%), Gaps = 85/573 (14%)

Query: 446 EAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATV----TPHTLQVAPGLQVEVATR 501
           ++AP T    A  + ++   +   E      +E T T      P T + AP    E A  
Sbjct: 292 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 351

Query: 502 VTPQAGE---EETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLC 558
              +      +E   T  +E A     +PS     E       T +  PT  +E + T  
Sbjct: 352 APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTT 408

Query: 559 PDSPQNLKEEGGLDL--PSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPL-PLQDTDLSS 615
             +P   KE        P+   P   A   P++     T P++ A T P  P   T    
Sbjct: 409 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP--TTPKEPAPTTPKEPAPTTTKKP 466

Query: 616 APKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLT 675
           AP         +   E   T P+++  T P  L  T     P+ +A  T      +   T
Sbjct: 467 AP---------TTPKEPAPTTPKETAPTTPKKLTPT----TPEKLAPTT----PEKPAPT 509

Query: 676 LPQDSA-MTPPLPLQDTDLSSAPK-PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 733
            P++ A  TP  P   T    AP  P AAA   +   E   T P++ A T P     T  
Sbjct: 510 TPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAPT-- 565

Query: 734 SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEG 793
              PK  A  T    +     TL + +  TP  P        APK +A  T         
Sbjct: 566 --TPKETAPTT---PKGTAPTTLKEPAPTTPKKP--------APKELAPTTTKE------ 606

Query: 794 LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 853
              P  +    P P       + PK  A  T      E   T P++ A T P     T L
Sbjct: 607 ---PTSTTCDKPAP-------TTPKGTAPTT----PKEPAPTTPKEPAPTTPKGTAPTTL 652

Query: 854 SSAPKPVAAATPVSQQAEEGLTLPQDSAMT---APLPLQDTGPTSGPEPLAVATPQTLQA 910
              P P     P  ++     T    S  +   AP   ++T PT+  EP     P T + 
Sbjct: 653 KE-PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP----APTTPKK 707

Query: 911 EAGCAPGTEPVATMAQQEVGEALGP---RPAPEEKNAALPTVPEPAALDQVQQDDPQPAA 967
            A   P T P  T           P     +P+E    L   P P AL+   ++   P  
Sbjct: 708 PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 767

Query: 968 E---AGTPWAAQEDADSTLGMEALSLPEPASGA 997
           +   A  P       D T   +  + PE  + A
Sbjct: 768 KTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 800



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 108/516 (20%), Positives = 161/516 (31%), Gaps = 59/516 (11%)

Query: 446 EAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQ 505
           E AP T    A  + ++   +   E      +E   T T       P       T+  P 
Sbjct: 339 EPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 398

Query: 506 AGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNL 565
             +E   +T          P P+             T E  PT  +E + T         
Sbjct: 399 TTKEPAPTTTKSAPTTPKEPSPT------------TTKEPAPTTPKEPAPTTPKKPAPTT 446

Query: 566 KEEGGLDLPSGRKPVAAATIVPRQAEEDL-TLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 624
            +E     P    P       P   +E   T P+++A T P  L  T             
Sbjct: 447 PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 506

Query: 625 IVSQQAEEGLTLPQDSV-MTPPLPLQDTELSSAPKPVA--AATLVSQQA-----EEGLTL 676
             +   E   T P++    TP  P   T  ++AP      A T   + A     E   T 
Sbjct: 507 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 566

Query: 677 PQDSAMTPPL---------PLQDTDLSSAPKPVAAATLVSQQA----EEGLTLPQDSAMT 723
           P+++A T P          P   T    APK +A  T     +    +   T P+ +A T
Sbjct: 567 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 626

Query: 724 PPL---------PLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 774
            P          P   T   +AP  +      + +      L   +   P     D    
Sbjct: 627 TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 686

Query: 775 SAPKPVAAATIVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEG 833
           + PK  A  T      E   T P+  A  TP  P   T   S P      T + +  +E 
Sbjct: 687 TTPKETAPTT----PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE- 741

Query: 834 LTLPQDSAMTPPLPLQD---------TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA 884
            + P+ SA   P  L++         T   +A KP    T   +  E  L    ++   A
Sbjct: 742 -STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 800

Query: 885 PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920
           P   ++T  T+     +  T  T Q  +     T P
Sbjct: 801 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 836


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 87.4 bits (215), Expect = 9e-17
 Identities = 184/798 (23%), Positives = 271/798 (33%), Gaps = 110/798 (13%)

Query: 611  TDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPL-QDTELSSAPKPVAAATLVSQQ 669
            T     PKP      V  +A  GL      V TP     Q  ++S++PK   A  +  + 
Sbjct: 115  TKKKPTPKPP-----VVDEAGSGLDNGDFKVTTPDTSTTQHNKVSTSPKITTAKPINPRP 169

Query: 670  A---------EEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQD 719
            +         E  LT+ +++ + T      +   S+  K    +   +Q  E+  T  +D
Sbjct: 170  SLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEK--TSAKD 227

Query: 720  SAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK- 778
             A T  +  + T  +       A T   +      T P++ A T P     T + SAP  
Sbjct: 228  LAPTSKVLAKPTPKAETTTKGPALTTPKEPTP---TTPKEPASTTPKEPTPTTIKSAPTT 284

Query: 779  -----PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEG 833
                 P    +  +   E   T  ++ A T P     T  +  P P    +  +   E  
Sbjct: 285  PKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT-TKEPAPTTTKSAPTTPKEPA 343

Query: 834  LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGP 893
             T P+  A T P     T     P P     P     E   T P++ A TAP   +   P
Sbjct: 344  PTTPKKPAPTTPKEPAPTT-PKEPTPTTPKEPAPTTKEPAPTTPKEPAPTAP---KKPAP 399

Query: 894  TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPA 953
            T+  EP A  TP+            EP  T   +E        PAP    +A  T  EPA
Sbjct: 400  TTPKEP-APTTPK------------EPAPT-TTKEPSPTTPKEPAPTTTKSAPTTTKEPA 445

Query: 954  ALD----QVQQDDPQP-AAEAGTPWAAQEDADSTLGMEALSLP-EPASGAGEEIAEALS- 1006
                        +P P   +   P   +E A +T    A + P EPA    +E A   + 
Sbjct: 446  PTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTK 505

Query: 1007 RPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDA 1066
            +P      E    T     P +P+K T                   P +    A   P+ 
Sbjct: 506  KPAPTTPKEPAPTTPKETAPTTPKKLT-------------------PTTPEKLAPTTPEK 546

Query: 1067 PPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRG 1126
            P    PE     L     EE   +    P PT P A A     +  P +      +    
Sbjct: 547  PAPTTPE----ELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT---- 598

Query: 1127 CPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLA----KGQPSTPVD 1182
             P  PAPT+ P    P    G          P+   TP    P+ LA    K   ST  D
Sbjct: 599  TPKEPAPTT-PKETAPTTPKGTAPTTLKEPAPT---TPKKPAPKELAPTTTKEPTSTTCD 654

Query: 1183 RPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAA 1242
            +P      AP T  G A    + PAP   ++P   + +   P  +L  P P    +PA  
Sbjct: 655  KP------APTTPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPT-TLKEPAPTTPKKPAPK 707

Query: 1243 AVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQG 1302
             ++ TT     GP  + S      +PK  +           P  + P P+ P++P     
Sbjct: 708  ELAPTTT---KGPTSTTSDKPAPTTPKETAPTTPKEPAPTTP--KKPAPTTPETPPPTTS 762

Query: 1303 LSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDI-LAPQTVQCP-AQAPAGG 1360
              +      E +    SP         +S  E SAE   + +  +P+    P  + PA  
Sbjct: 763  EVSTPTTTKEPTTIHKSP--------DESTPELSAEPTPKALENSPKEPGVPTTKTPAAT 814

Query: 1361 SEETIAKAKQSRSEKKAR 1378
              E    AK   +E+  R
Sbjct: 815  KPEMTTTAKDKTTERDLR 832



 Score = 84.7 bits (208), Expect = 6e-16
 Identities = 171/811 (21%), Positives = 269/811 (33%), Gaps = 99/811 (12%)

Query: 484  TPHTLQVAPGLQVEVATRVTPQAGE--EETDSTAGQESAAMAMPQPSQEGISEILGQESV 541
            TP T++ AP    E A   T  A    +E   T  +E A     +P+     E       
Sbjct: 274  TPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKE---PAPT 330

Query: 542  TAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSA 601
            T +  PT  +E + T          +E     P    P       P   E   T P++ A
Sbjct: 331  TTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPA 390

Query: 602  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVA 661
             T P            KP  A T   + A      P  +    P P    E    P P  
Sbjct: 391  PTAP-----------KKP--APTTPKEPAPTTPKEPAPTTTKEPSPTTPKE----PAPTT 433

Query: 662  AATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSA 721
              +  +   E   T  + +  TP  P   T    AP         + +     T  + + 
Sbjct: 434  TKSAPTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAP 493

Query: 722  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 781
             TP  P   T    AP         +   E   T P+++A T P  L  T     P+ +A
Sbjct: 494  TTPKEPAPTTTKKPAP---------TTPKEPAPTTPKETAPTTPKKLTPT----TPEKLA 540

Query: 782  AATIVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAP-KPVAAATLVSQQAEEGLTLPQD 839
              T      +   T P++ A  TP  P   T    AP  P AAA   +   E   T P++
Sbjct: 541  PTT----PEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKE 594

Query: 840  SAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEP 899
             A T P     T     PK  A  TP                 TAP  L++  PT+  +P
Sbjct: 595  PAPTTPKEPAPT----TPKETAPTTPKG---------------TAPTTLKEPAPTTPKKP 635

Query: 900  LAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQ 959
                   T   E       +P  T   +         PAP       PT P+  A   ++
Sbjct: 636  APKELAPTTTKEPTSTTCDKPAPT-TPKGTAPTTPKEPAPTTPKEPAPTTPKGTAPTTLK 694

Query: 960  QDDP----QPAAEAGTPWAAQEDADSTLGMEALSLP-EPASGAGEEIAEALSRPGREACL 1014
            +  P    +PA +   P   +    +T    A + P E A    +E A    +       
Sbjct: 695  EPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEPAPTTPKKPAPTTP 754

Query: 1015 EARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEV 1074
            E    T       +  KE   +    +     L+ E  P+ AL  + + P  P    P  
Sbjct: 755  ETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPK-ALENSPKEPGVPTTKTPAA 813

Query: 1075 SQARLLSPARE---ERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAP 1131
            ++  + + A++   ER L  ++TPE T  +   T+ +  +  +++   +++         
Sbjct: 814  TKPEMTTTAKDKTTERDL--RTTPETTTAAPKMTKETATTTEKTTESKITA-------TT 864

Query: 1132 APTSAPTSQQPEP--VLGLGSVEQPHEV----PSVLGTPLLQPPENLAKGQPSTPVDRPL 1185
               ++ T+Q   P  +  L +     +V     ++  T ++  PE  AK +      +  
Sbjct: 865  TQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIMNKPEETAKPKDRATNSKAT 924

Query: 1186 GPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1245
             P P           P   P  P   + P+  ++     P +   P       P     S
Sbjct: 925  TPKPQK---------PTKAPKKPTSTKKPK--TMPRVRKPKTTPTPRKMTSTMPELNPTS 973

Query: 1246 GTTQP-LGTGPRVSLSPHSPLLSPKVASMDA 1275
               +  L T  R + +P+S L+     S DA
Sbjct: 974  RIAEAMLQTTTRPNQTPNSKLVEVNPKSEDA 1004



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 136/573 (23%), Positives = 193/573 (33%), Gaps = 85/573 (14%)

Query: 446 EAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATV----TPHTLQVAPGLQVEVATR 501
           ++AP T    A  + ++   +   E      +E T T      P T + AP    E A  
Sbjct: 333 KSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT 392

Query: 502 VTPQAGE---EETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLC 558
              +      +E   T  +E A     +PS     E       T +  PT  +E + T  
Sbjct: 393 APKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKE---PAPTTTKSAPTTTKEPAPTTT 449

Query: 559 PDSPQNLKEEGGLDL--PSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPL-PLQDTDLSS 615
             +P   KE        P+   P   A   P++     T P++ A T P  P   T    
Sbjct: 450 KSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAP--TTPKEPAPTTPKEPAPTTTKKP 507

Query: 616 APKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLT 675
           AP         +   E   T P+++  T P  L  T     P+ +A  T      +   T
Sbjct: 508 AP---------TTPKEPAPTTPKETAPTTPKKLTPT----TPEKLAPTT----PEKPAPT 550

Query: 676 LPQDSA-MTPPLPLQDTDLSSAPK-PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 733
            P++ A  TP  P   T    AP  P AAA   +   E   T P++ A T P     T  
Sbjct: 551 TPEELAPTTPEEPTPTTPEEPAPTTPKAAAP--NTPKEPAPTTPKEPAPTTPKEPAPT-- 606

Query: 734 SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEG 793
              PK  A  T    +     TL + +  TP  P        APK +A  T         
Sbjct: 607 --TPKETAPTT---PKGTAPTTLKEPAPTTPKKP--------APKELAPTTTKE------ 647

Query: 794 LTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 853
              P  +    P P       + PK  A  T      E   T P++ A T P     T L
Sbjct: 648 ---PTSTTCDKPAP-------TTPKGTAPTT----PKEPAPTTPKEPAPTTPKGTAPTTL 693

Query: 854 SSAPKPVAAATPVSQQAEEGLTLPQDSAMT---APLPLQDTGPTSGPEPLAVATPQTLQA 910
              P P     P  ++     T    S  +   AP   ++T PT+  EP     P T + 
Sbjct: 694 KE-PAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP----APTTPKK 748

Query: 911 EAGCAPGTEPVATMAQQEVGEALGP---RPAPEEKNAALPTVPEPAALDQVQQDDPQPAA 967
            A   P T P  T           P     +P+E    L   P P AL+   ++   P  
Sbjct: 749 PAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSPKEPGVPTT 808

Query: 968 E---AGTPWAAQEDADSTLGMEALSLPEPASGA 997
           +   A  P       D T   +  + PE  + A
Sbjct: 809 KTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 841



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 108/516 (20%), Positives = 161/516 (31%), Gaps = 59/516 (11%)

Query: 446 EAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQ 505
           E AP T    A  + ++   +   E      +E   T T       P       T+  P 
Sbjct: 380 EPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 439

Query: 506 AGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNL 565
             +E   +T          P P+             T E  PT  +E + T         
Sbjct: 440 TTKEPAPTTTKSAPTTPKEPSPT------------TTKEPAPTTPKEPAPTTPKKPAPTT 487

Query: 566 KEEGGLDLPSGRKPVAAATIVPRQAEEDL-TLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 624
            +E     P    P       P   +E   T P+++A T P  L  T             
Sbjct: 488 PKEPAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP 547

Query: 625 IVSQQAEEGLTLPQDSV-MTPPLPLQDTELSSAPKPVA--AATLVSQQA-----EEGLTL 676
             +   E   T P++    TP  P   T  ++AP      A T   + A     E   T 
Sbjct: 548 APTTPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 607

Query: 677 PQDSAMTPPL---------PLQDTDLSSAPKPVAAATLVSQQA----EEGLTLPQDSAMT 723
           P+++A T P          P   T    APK +A  T     +    +   T P+ +A T
Sbjct: 608 PKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPT 667

Query: 724 PPL---------PLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 774
            P          P   T   +AP  +      + +      L   +   P     D    
Sbjct: 668 TPKEPAPTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAP 727

Query: 775 SAPKPVAAATIVSQQAEEGLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEG 833
           + PK  A  T      E   T P+  A  TP  P   T   S P      T + +  +E 
Sbjct: 728 TTPKETAPTT----PKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDE- 782

Query: 834 LTLPQDSAMTPPLPLQD---------TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA 884
            + P+ SA   P  L++         T   +A KP    T   +  E  L    ++   A
Sbjct: 783 -STPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRTTPETTTAA 841

Query: 885 PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEP 920
           P   ++T  T+     +  T  T Q  +     T P
Sbjct: 842 PKMTKETATTTEKTTESKITATTTQVTSTTTQDTTP 877


>gi|132626688 mediator of DNA-damage checkpoint 1 [Homo sapiens]
          Length = 2089

 Score = 85.5 bits (210), Expect = 4e-16
 Identities = 197/860 (22%), Positives = 294/860 (34%), Gaps = 121/860 (14%)

Query: 538  QESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLP 597
            QES  A   PT  E  +    P + Q+ K      L S   P    T+  R+  +D    
Sbjct: 1031 QESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTV--RKTRQD---- 1084

Query: 598  QDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAP 657
              S   P  PL        PKP     I ++++      P  S    P P   T     P
Sbjct: 1085 -GSQEAPEAPLSSELEPFHPKP----KIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTP 1139

Query: 658  KPVAAATLVSQQAEEGLTLPQDSAMTPP--LPLQDTDLSSAPKPVAAATLVSQQAEEGLT 715
            KP + AT  S+     +  P+    T P   P   TD     +P +  T   +++   + 
Sbjct: 1140 KPTSQATR-SRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTR-GRKSRSSVK 1197

Query: 716  LPQDSAMTPP--LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP--LPLQDT 771
             P+    T     P   TD     +P + AT   ++    +  P+    T P   P   T
Sbjct: 1198 TPETVVPTALELQPSTSTDRPVTSEPTSQATR-GRKNRSSVKTPEPVVPTAPELQPSTST 1256

Query: 772  DLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPP--LPLQDTDLSSAPKPVAAATLVSQQ 829
            D     +P   AT   ++    +  P+    T P   P   TD    PKP +  T  S+ 
Sbjct: 1257 DQPVTSEPTYQATR-GRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTR-SRT 1314

Query: 830  AEEGLTLPQDSAMTPPLPLQ---DTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPL 886
                +  P+    T P  LQ    TD    PKP +  T  S+     +  P+ +   AP 
Sbjct: 1315 NMSSVKTPETVVPTAP-ELQISTSTDQPVTPKPTSRTTR-SRTNMSSVKNPESTVPIAPE 1372

Query: 887  --PLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT---------------EPVATMAQQEV 929
              P   T     PEP + AT       +G  P T               +PV      + 
Sbjct: 1373 LPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLEPSTSTDQPVTPEPTSQA 1432

Query: 930  GEALGPRPAPEEKNAALPTVPE---PAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGME 986
                  R + +     +PT PE     + DQ    +P   A  G    +      T+   
Sbjct: 1433 TRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQATRGRTDRSSVKTPETVVPT 1492

Query: 987  ALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKP 1046
            A  L   AS      +E  SR  R     +   T +   P +P+ +     +Q      P
Sbjct: 1493 APELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVVPAAPELQPSTSTDQ------P 1546

Query: 1047 LAQEHGPRSALGGARE---------VPDAPPAACPEVSQARLLSPAREERGL------SG 1091
            +  E   R+  G             VP AP    P  S+ +L++P    R        S 
Sbjct: 1547 VTPEPTSRATRGRTNRSSVKTPESIVPIAPELQ-PSTSRNQLVTPEPTSRATRCRTNRSS 1605

Query: 1092 KSTPEPTLPSAV----ATEASLDSCPESSVGAV------SSLDRGCPDAPAPTS----AP 1137
              TPEP +P+A      T       P+ +  A       SS+    P  PA +      P
Sbjct: 1606 VKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSVKTPKPVEPAASDLEPFTP 1665

Query: 1138 TSQQPEP-VLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSA----- 1191
            T Q   P  +  G   +     +V   P+   PE     Q     D+P+ P+P       
Sbjct: 1666 TDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEF----QSPVTTDQPISPEPITQPSCI 1721

Query: 1192 --------PGTLAGA-----ALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPP-PQAGV 1237
                    PG+LA          PLEP +    ++ +  +V   E   ++  P  PQ   
Sbjct: 1722 KRQRAAGNPGSLAAPIDHKPCSAPLEPKSQA-SRNQRWGAVRAAESLTAIPEPASPQLLE 1780

Query: 1238 QPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSP 1297
             P  A+     +P G       S  +P L PK +    + LA    PP Q  P  G  S 
Sbjct: 1781 TPIHASQIQKVEPAGR------SRFTPELQPKASQSRKRSLATMDSPPHQKQPQRGEVSQ 1834

Query: 1298 AGPQGLSAPEQQEDEDSLEE 1317
                  +   ++E+ED+ E+
Sbjct: 1835 K-----TVIIKEEEEDTAEK 1849



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 171/812 (21%), Positives = 274/812 (33%), Gaps = 103/812 (12%)

Query: 487  TLQVAPGLQVEVATRVTPQAG--EEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAE 544
            T+    G+  E A RV P+ G  E ET+    +    +   +   +G  +   ++ +  +
Sbjct: 809  TVDKVMGIPKETAERVGPERGPLERETEKLLPERQTDVTGEEELTKGKQDREQKQLLARD 868

Query: 545  KLPTPQEETSLTLCPDSP-QNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMT 603
                  ++   +  P+   ++LK E         K V   T+  +  E ++  P  +   
Sbjct: 869  TQRQESDKNGESASPERDRESLKVEIETSEEIQEKQVQKQTLPSKAFEREVERPVANREC 928

Query: 604  PPLPLQDTDLSSAPKPVAAATIVSQQAE-EGLTLPQDSVMTPPLPLQDTELSSAPKPVAA 662
             P  L++      PK +      +Q+ E EG +  Q    + P P         P P +A
Sbjct: 929  DPAELEE----KVPKVILERD--TQRGEPEGGSQDQKGQASSPTPEPGVGAGDLPGPTSA 982

Query: 663  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKP--VAAATLVSQQAEEG--LTLPQ 718
               V   ++ G      S       L +  +  A K   + AA  VS+  +E     LP 
Sbjct: 983  P--VPSGSQSGGRGSPVSPRRHQKGLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPP 1040

Query: 719  DSAMTPPLPLQDTDLSS----APKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS 774
                 P  P +  +  S    AP P+ +  L S +     T    S   P  PL      
Sbjct: 1041 TVPEAPAPPQKPLNSQSQKHLAPPPLLSPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEP 1100

Query: 775  SAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGL 834
              PKP     I ++++      P  SA   P P   T     PKP + AT  S+     +
Sbjct: 1101 FHPKP----KIRTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATR-SRTNRSSV 1155

Query: 835  TLPQDSAMTPP--LPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTG 892
              P+    T P   P   TD     +P +  T   +++   +  P+    TA L LQ + 
Sbjct: 1156 KTPEPVVPTAPELQPSTSTDQPVTSEPTSQVTR-GRKSRSSVKTPETVVPTA-LELQPST 1213

Query: 893  PTSGP---EPLAVATP--------QTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEE 941
             T  P   EP + AT         +T +     AP  +P +T   Q V      +     
Sbjct: 1214 STDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQP-STSTDQPVTSEPTYQATRGR 1272

Query: 942  KNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEI 1001
            KN +    PEP      +           TP        S   M ++  PE       E 
Sbjct: 1273 KNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMSSVKTPETVVPTAPE- 1331

Query: 1002 AEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAR 1061
                        L+    T     P    + T    N        ++    P S +  A 
Sbjct: 1332 ------------LQISTSTDQPVTPKPTSRTTRSRTN--------MSSVKNPESTVPIAP 1371

Query: 1062 EVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVS 1121
            E+P +     P   +    +    +   SGK TPE  +P+A   E S  +          
Sbjct: 1372 ELPPSTSTEQPVTPEPTSRATRGRKNRSSGK-TPETLVPTAPKLEPSTST---------- 1420

Query: 1122 SLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPV 1181
                   D P  T  PTSQ         SV+ P  V  V   P LQP         ST  
Sbjct: 1421 -------DQPV-TPEPTSQATRGRTNRSSVKTPETV--VPTAPELQP---------STST 1461

Query: 1182 DRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQ-EDSVEDEEPPGSLGLPPPQAGVQPA 1240
            D+P+ P+P++  T        ++ P   +   P+ + S   ++P  S          +P 
Sbjct: 1462 DQPVTPEPTSQATRGRTDRSSVKTPETVVPTAPELQASASTDQPVTS----------EPT 1511

Query: 1241 AAAVSGTTQPLGTGPRVSLSPHSPLLSPKVAS 1272
            +    G           ++ P +P L P  ++
Sbjct: 1512 SRTTRGRKNRSSVKTPETVVPAAPELQPSTST 1543



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 186/904 (20%), Positives = 302/904 (33%), Gaps = 150/904 (16%)

Query: 470  EEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQP-S 528
            EEG +L     A V    L        E A  V  Q    E  +  G   A +    P S
Sbjct: 582  EEGTSLTASVVADVRKSQLPAEGDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPIS 641

Query: 529  QEGISEILGQESVTAE---------KLPTPQE-ETSLTLCPDSPQNLKEEGGLDLPSGRK 578
            +E +++++       E         ++PT +E E  +    DS  N  +   LDL + + 
Sbjct: 642  RENLTDLVVDTDTLGESTQPQREGAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQC 701

Query: 579  PVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQ 638
             +    +   Q+ ED    Q   +TPP  L  +  S              Q    L  P 
Sbjct: 702  FLENQGLEAVQSMEDEPT-QAFMLTPPQELGPSHCSF-------------QTTGTLDEPW 747

Query: 639  DSVMTPPLPLQDTELSSAPK-----PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 693
            + + T P  L+++E S               L   +A  G   P+    T P+ +Q    
Sbjct: 748  EVLATQPFCLRESEDSETQPFDTHLEAYGPCLSPPRAIPGDQHPESPVHTEPMGIQGRGR 807

Query: 694  SSAPKPVAAATLVSQQA--EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAE 751
             +  K +      +++   E G   P +      LP + TD++                E
Sbjct: 808  QTVDKVMGIPKETAERVGPERG---PLERETEKLLPERQTDVTG---------------E 849

Query: 752  EGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDT 811
            E LT  +       L  +DT    + K   +A+   ++  E L +  +           T
Sbjct: 850  EELTKGKQDREQKQLLARDTQRQESDKNGESAS--PERDRESLKVEIE-----------T 896

Query: 812  DLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAE 871
                  K V   TL S+  E  +  P  +    P  L++      PK +      +Q+ E
Sbjct: 897  SEEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEE----KVPKVILERD--TQRGE 950

Query: 872  -EGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVG 930
             EG +  Q    ++P P    G    P P +   P   Q+    +P    V+    Q+  
Sbjct: 951  PEGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSP----VSPRRHQK-- 1004

Query: 931  EALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSL 990
              L  +  P EK + +    + +  DQ   D   P      P   Q+  +S    + L+ 
Sbjct: 1005 GLLNCKMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQ-SQKHLAP 1063

Query: 991  PEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQE 1050
            P   S     I   + +  ++   EA         P++P    LE          P  + 
Sbjct: 1064 PPLLSPLLPSIKPTVRKTRQDGSQEA---------PEAPLSSELEP-------FHPKPKI 1107

Query: 1051 HGPRSALGGAREVPDAPPAACPEVSQARLLSP------AREERGLSGKSTPEPTLPSAVA 1104
               +S+         A P   P  S A+ ++P       R     S   TPEP +P+A  
Sbjct: 1108 RTRKSSRMTPFPATSAAPEPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPE 1167

Query: 1105 TEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEV-PSVLGT 1163
             + S  +                 D P  TS PTSQ         SV+ P  V P+ L  
Sbjct: 1168 LQPSTST-----------------DQPV-TSEPTSQVTRGRKSRSSVKTPETVVPTALEL 1209

Query: 1164 PLLQPPENLAKGQPSTPVDRPLGPDPSAPGT-----LAGAALP-PLEPPAPCLCQDPQED 1217
                        QPST  DRP+  +P++  T      +    P P+ P AP L      D
Sbjct: 1210 ------------QPSTSTDRPVTSEPTSQATRGRKNRSSVKTPEPVVPTAPELQPSTSTD 1257

Query: 1218 SVEDEEPP----------GSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRV----SLSPHS 1263
                 EP            S+  P P     P     + T +P+   P      S +  S
Sbjct: 1258 QPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDRPVTPKPTSRTTRSRTNMS 1317

Query: 1264 PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRAL 1323
             + +P+     A +L +       V P    ++      +S+ +  E    +  + P + 
Sbjct: 1318 SVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNMSSVKNPESTVPIAPELPPST 1377

Query: 1324 GSGQ 1327
             + Q
Sbjct: 1378 STEQ 1381


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 141/568 (24%), Positives = 201/568 (35%), Gaps = 53/568 (9%)

Query: 698  KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA-PKPVAAATLVSQQAEEGLTL 756
            K V  A       EE + + Q  + T  +P     L +A P P    ++ +  A EG  +
Sbjct: 812  KQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAV 871

Query: 757  PQDSAMTPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTD 812
                A   P P +D  ++S      + V AA +    A E  T+P  +   P        
Sbjct: 872  V---AALVPFPHEDILVASIVSLEEEDVTAAAV---SAPERATVPAVTVSVPEGTAAVAA 925

Query: 813  LSS----APKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQ 868
            +SS    AP   AA T     A  G + P+ +A+   +P+ + D  +   PV  AT V  
Sbjct: 926  VSSPEETAPAVAAAITQEGMSAVAGFS-PEWAALAITVPITEED-GTPEGPVTPATTVHA 983

Query: 869  QAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQE 928
              E     P  +A+    P +   P +     AV TP+   + A   P  E   + A   
Sbjct: 984  PEE-----PDTAAVRVSTPEEPASPAA-----AVPTPEEPTSPAAAVPTPEEPTSPAA-- 1031

Query: 929  VGEALGPRPAPEEKNAALPTVPEP---AALDQVQQDDPQPAAEAGTPWAAQEDADSTLGM 985
               A+ P   P    AA+PT  EP   AA     ++   PAA   TP      A +    
Sbjct: 1032 ---AVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTP 1088

Query: 986  EALSLPEPASGAGEEI---AEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEG 1042
            E  + P  A    EE    A A+  P   A   A   T     P+ P      V   +E 
Sbjct: 1089 EEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPT-----PEEPASPAAAVPTPEEP 1143

Query: 1043 GLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKST-PEPTLPS 1101
               P      P  +   A  VP    +A P    A + +PA      +  +T  EPT P+
Sbjct: 1144 AF-PAPAVPTPEESASAAVAVPTPEESASPA---AAVPTPAESASFAAVVATLEEPTSPA 1199

Query: 1102 A-VATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSV 1160
            A V T A++ +  E      +S+     + PA  +A  S   EP     +V    E  S 
Sbjct: 1200 ASVPTPAAMVATLEEFTSPAASVPTS--EEPASLAAAVSNPEEPTSPAAAVPTLEEPTSS 1257

Query: 1161 LGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVE 1220
                L   PE L+    S P         +A   L   A P    P P +   P      
Sbjct: 1258 AAAVLT--PEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPT 1315

Query: 1221 DEEPPGSLGLPPPQAGVQPAAAAVSGTT 1248
             E P       PP   V P      G +
Sbjct: 1316 PEVPAIPAAAVPPMEEVSPIGVPFLGVS 1343



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 140/587 (23%), Positives = 208/587 (35%), Gaps = 100/587 (17%)

Query: 658  KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA-PKPVAAATLVSQQAEEGLTL 716
            K V  A       EE + + Q  + T  +P     L +A P P    ++ +  A EG  +
Sbjct: 812  KQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAV 871

Query: 717  PQDSAMTPPLPLQDTDLSSAPK-PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS 775
                A   P P +D  ++S         T  +  A E  T+P  +   P        +SS
Sbjct: 872  V---AALVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSS 928

Query: 776  ----APKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAE 831
                AP   AA T     A  G + P+ +A+   +P+ + D  +   PV  AT V    E
Sbjct: 929  PEETAPAVAAAITQEGMSAVAGFS-PEWAALAITVPITEED-GTPEGPVTPATTVHAPEE 986

Query: 832  EGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDT 891
                 P  +A+    P +       P   AAA P  ++       P   A   P P + T
Sbjct: 987  -----PDTAAVRVSTPEE-------PASPAAAVPTPEE-------PTSPAAAVPTPEEPT 1027

Query: 892  GPTSGPEP--------LAVATPQTLQAEAGCAP----GTEPVATM-AQQEVGEALGPRPA 938
             P +   P         AV TP+   + A   P     T P A +   +E        P 
Sbjct: 1028 SPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPT 1087

Query: 939  PEEKN---AALPTVPE---PAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPE 992
            PEE     AA+PT  E   PAA     ++   PAA   TP      A +    E  + P 
Sbjct: 1088 PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPA 1147

Query: 993  PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHG 1052
            PA    EE A A                       +P+      E+       P   E  
Sbjct: 1148 PAVPTPEESASA------------------AVAVPTPE------ESASPAAAVPTPAESA 1183

Query: 1053 PRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSC 1112
              +A+    E P +P A+ P  +    +    EE      S P    P+++A   S    
Sbjct: 1184 SFAAVVATLEEPTSPAASVPTPA---AMVATLEEFTSPAASVPTSEEPASLAAAVSNPEE 1240

Query: 1113 PESSVGAVSSLDRGCPDAPA----------PTSAPTSQQP-EPVLGLGSVEQPHEVPSVL 1161
            P S   AV +L+     A A            S PT ++P  P   + ++E+P    + +
Sbjct: 1241 PTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAV 1300

Query: 1162 GTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAP 1208
             TP +          P+  V     P P  P  +  AA+PP+E  +P
Sbjct: 1301 PTPEV-------AAIPAASV-----PTPEVP-AIPAAAVPPMEEVSP 1334



 Score = 58.2 bits (139), Expect = 6e-08
 Identities = 109/496 (21%), Positives = 177/496 (35%), Gaps = 84/496 (16%)

Query: 922  ATMAQQEVGEALGPRPAPEEKNAALPTVPEP------AALDQVQQDDPQPAA-----EAG 970
            A +   E G ++   PAPE        VP P      A++  ++++D   AA      A 
Sbjct: 849  AALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAAVSAPERAT 908

Query: 971  TPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPD--- 1027
             P       + T  + A+S PE  + A   +A A+++ G  A          G  P+   
Sbjct: 909  VPAVTVSVPEGTAAVAAVSSPEETAPA---VAAAITQEGMSAVA--------GFSPEWAA 957

Query: 1028 -SPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREE 1086
             +      E +   EG + P    H P                  P+ +  R+ +P  EE
Sbjct: 958  LAITVPITEEDGTPEGPVTPATTVHAPEE----------------PDTAAVRVSTP--EE 999

Query: 1087 RGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQP-EPV 1145
                  + P P  P++ A        P S   AV   +   P +PA  + PT ++P  P 
Sbjct: 1000 PASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEE--PTSPA-AAVPTPEEPTSPA 1056

Query: 1146 LGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALP-PLE 1204
              + + E+P    + + TP           +P++P      P P  P T   AA+P P E
Sbjct: 1057 AAVPTPEEPTSPAAAVPTP----------EEPTSPAAAV--PTPEEP-TSPAAAVPTPEE 1103

Query: 1205 PPAPCLCQDPQED------SVEDEEPPGS--LGLPPPQAGVQPAAAA----VSGTTQPLG 1252
            P +P       E+      +V   E P S    +P P+    PA A      S +     
Sbjct: 1104 PTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAV 1163

Query: 1253 TGPRVSLSPHSPLLSPKVASMDAKDLAL---QILPPCQVPPPSGPQSPAGPQGLSAPEQQ 1309
              P  S SP + + +P  ++  A  +A       P   VP P+     A  +  ++P   
Sbjct: 1164 PTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAA--MVATLEEFTSPAAS 1221

Query: 1310 EDEDSLEEDSPRALGSGQHSDSHGESSAELDEQD-----ILAPQTVQCPAQAPAGGSEET 1364
                        A+ + +   S   +   L+E       +L P+ +  PA +     E  
Sbjct: 1222 VPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPA 1281

Query: 1365 IAKAKQSRSEKKARKA 1380
               A  S  E+ A  A
Sbjct: 1282 SPAAAVSNLEEPASPA 1297


>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
            [Homo sapiens]
          Length = 1451

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 198/972 (20%), Positives = 339/972 (34%), Gaps = 144/972 (14%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  ----------GLDLP------------SGRKPVAAA-----TIVPRQAEEDLTLPQDSAM 602
                      G  +P            SG+ P  +A     T +  + EE+ ++P   A 
Sbjct: 126  KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185

Query: 603  TPPLPLQDTDLSSAPKPVAAAT----IVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK 658
              P  +      S+ +  ++++    +  + + +   +   SV T   P +     +AP 
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR----KAAPA 241

Query: 659  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ 718
            P      V+ Q + G   P   A  P    + ++  S  +  A A   SQ       L  
Sbjct: 242  PGKVGD-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 778
             +A  P         + AP   A A  V+ Q + G   P++ + +        + S + +
Sbjct: 301  RAASAPAKGTPGKGATPAPPGKAGA--VASQTKAGK--PEEDSES-----SSEESSDSEE 351

Query: 779  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATLVSQQAEEGL 834
               AA  + Q    G T    +A  P         + AP     P  A     ++ E+  
Sbjct: 352  ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 411

Query: 835  TLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPT 894
            +  ++S      P Q      AP+  AA+ P  +   +G          AP P + TGP 
Sbjct: 412  SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAPAPPRKTGPA 462

Query: 895  -------------------SGPEPLAVATPQTLQAEA-GCAPGTEPVATMAQQEVGEALG 934
                               S  +  A+A     Q +  G +P  +P +TM    +G+  G
Sbjct: 463  AAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522

Query: 935  PRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLG--MEALSL 990
            P P P +   A P+  V +     +   ++   +++   P A     + +LG  ++A   
Sbjct: 523  PVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581

Query: 991  PEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETLEVENQQEGGLKPL 1047
              PA G  ++      +   E  +   E+   + D A  DS +        Q +  LK  
Sbjct: 582  SSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAAMTAAQAKPALKIP 639

Query: 1048 AQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVAT 1105
              +  P+  +    A+  P       P  +     SPA     ++G  T  P   S+ + 
Sbjct: 640  QTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG-GTQRPAEDSSSSE 697

Query: 1106 EASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPVL------------ 1146
            E+  DS  E +     VG   S+ +G     A  P      Q   PVL            
Sbjct: 698  ES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVK 755

Query: 1147 -----GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGA 1198
                    S E+  +      +P        +  AK  P+           SAPG +  A
Sbjct: 756  AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTA 815

Query: 1199 ALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPL 1251
            A          ++PP     ++PQ  +V    P     +P     V  AA A +G  +  
Sbjct: 816  AAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVATAAQAQTGPEEDS 868

Query: 1252 GTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQE 1310
            G+    S S   +  L+    S     +   + P  + P      +P G  G SA +  +
Sbjct: 869  GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928

Query: 1311 DEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQ 1370
             +DS          S + SDS GE+ A +    ++ P  +         G   T A+A+ 
Sbjct: 929  QDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQA 980

Query: 1371 SRSEKKARKAMS 1382
            + + +KAR + S
Sbjct: 981  ASTPRKARASES 992



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 243/1186 (20%), Positives = 408/1186 (34%), Gaps = 167/1186 (14%)

Query: 348  LAGEGEEDSTSASFLQSLSDLSITEGMDEAF---AFRDDTSAASSDSDSASYAEADDERL 404
            L+G+    S   S   +L   +  EG   AF   A     SA  +DS S   + + DE  
Sbjct: 152  LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211

Query: 405  YSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL 464
              G+P  +   ++ S   T+E     A     + G V+  V+       + A   ++ E 
Sbjct: 212  VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA---KKPEE 268

Query: 465  ISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT---RVTPQAGEEETDSTAGQESAA 521
             SE +EEG    +E+ A            LQV  A+   + TP  G+  T +  G+  A 
Sbjct: 269  ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP--GKGATPAPPGKAGAV 326

Query: 522  MAM-----PQPSQEGISEILGQESVTAEKLPTPQE--------ETSLTLCPDSP-QNLKE 567
             +      P+   E  SE   + S + E+ P  +         +TS      +P +    
Sbjct: 327  ASQTKAGKPEEDSESSSE---ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR 383

Query: 568  EGGLDLPSGRK-PVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 626
            +G    P G+  P  A     ++ E+  +  ++S      P Q      AP+  AA+   
Sbjct: 384  KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443

Query: 627  SQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDS-----A 681
             +   +G           P P + T       P AA   V +Q E+  +  ++S     A
Sbjct: 444  KESPRKG---------AAPAPPRKT------GPAAAQVQVGKQEEDSRSSSEESDSDREA 488

Query: 682  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL-------QDTDLS 734
            +      Q   L  +P+   A+T+      +G        + P  P        +D++ S
Sbjct: 489  LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 735  ------SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 788
                  S+   V  A   +Q+   G  L      +P         +  P   A    V  
Sbjct: 549  SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP---------AKGPPQKAGPVAVQV 599

Query: 789  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 848
            +AE+    P D++ +        D   AP  + AA     QA+  L +PQ  A       
Sbjct: 600  KAEK----PMDNSESSEESSDSADSEEAPAAMTAA-----QAKPALKIPQTKACPKK--- 647

Query: 849  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA---PLPLQDTGPTSGPEPLAVATP 905
             +T  S+   PV   T   ++A    +    S   A     P +D+  +   +     T 
Sbjct: 648  TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707

Query: 906  QTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQP 965
              +      + G       A   V  +LG   AP       PTV +  A  + Q+D    
Sbjct: 708  LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA--EKQEDSESS 765

Query: 966  AAEAGTPWAAQEDAD-STLGMEALSLPEPASGAGEEIAEALSRPGR--EACLEARAHTGD 1022
              E+ +  AA   A   T   +  +   PA+         +S PG+   A  +A+  +  
Sbjct: 766  EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825

Query: 1023 GAKPD--SPQKETL------EVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAA---- 1070
              KP   +PQ  T+       V +  +        + GP    G + E  D+   A    
Sbjct: 826  KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLA 885

Query: 1071 ----CPEVSQAR-LLSPAREE-RGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLD 1124
                  +  Q R  L+PA+E  R  +  + P  T PSA       DS         SS +
Sbjct: 886  QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS--------GSSSE 937

Query: 1125 RGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRP 1184
                D  AP +  ++Q  +P L       P+  P+        P    A+ Q ++   + 
Sbjct: 938  ESDSDGEAPAAVTSAQVIKPPL---IFVDPNRSPA-------GPAATPAQAQAASTPRKA 987

Query: 1185 LGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPA--AA 1242
               + +A  + + +    + P   CL    + + V        +      AG   +  ++
Sbjct: 988  RASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESS 1047

Query: 1243 AVSGTTQPLGTGPRVSLSPHS-PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQ 1301
             +S   +  G   +V  +  + P  SP+  S+ AK                 P+ P   Q
Sbjct: 1048 RISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG----------TNKLRKPKLPEVQQ 1097

Query: 1302 GLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1361
               APE  +D +   + S     SG   D  G   A+     +            P    
Sbjct: 1098 ATKAPESSDDSEDSSDSS-----SGSEEDGEGPQGAKSAHTLV-----------GPTPSR 1141

Query: 1362 EETIAK--AKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASD 1419
             ET+ +  A +S  +     + S L      G+T    Q SK      A P +  SP+  
Sbjct: 1142 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK------ATPKLDSSPSVS 1195

Query: 1420 TYVVF---GEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPR 1462
            + +      + K E   QQ     + K       S   P+ + +P+
Sbjct: 1196 STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1241



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 155/802 (19%), Positives = 276/802 (34%), Gaps = 91/802 (11%)

Query: 729  QDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 788
            +D  L +    V+     S+ +EE      ++A   P       L+S    V  A + S 
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPR------LASTNSSVLGADLPSS 120

Query: 789  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 848
              E+     + +  T          +S P P    T+ +  + +      + +    L  
Sbjct: 121  MKEKAKAETEKAGKTG---------NSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS 171

Query: 849  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTL 908
            +  +  S P   AAA P    A +  +  +D++ ++     +  P+  P  +  ++  T 
Sbjct: 172  ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231

Query: 909  QAEAG-CAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAA 967
            ++ A   AP    V  +  Q  G AL P    ++        PE  +    +  + +  A
Sbjct: 232  ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK--------PEEESESSEEGSESEEEA 283

Query: 968  EAGTPWAAQEDADSTLGMEALSLPEPAS-GAGEEIAEALSRPGREACLEARAHTGDGAKP 1026
             AGT  +  + ++  L + A S P   + G G   A     PG+   + ++   G   + 
Sbjct: 284  PAGTR-SQVKASEKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTKAGKPEED 338

Query: 1027 DSPQKETLEVENQQEGGLKPL--AQEHGPRSALGGA----REVP-----DAPPAAC-PEV 1074
                 E      ++    K L  A+  G  S +G A    +E P      APP    P V
Sbjct: 339  SESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398

Query: 1075 SQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPT 1134
            ++A+      + +  S +S  E   P+             +S  A  S  +G   AP   
Sbjct: 399  AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458

Query: 1135 SAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGT 1194
            + P + Q +    +G  E+     S          +  A    +    +PLG  P     
Sbjct: 459  TGPAAAQVQ----VGKQEEDSRSSSEESDS-----DREALAAMNAAQVKPLGKSPQVK-- 507

Query: 1195 LAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTG 1254
                       PA  +   P           G+  +PP + G    +A V    +   + 
Sbjct: 508  -----------PASTMGMGPLGK--------GAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 1255 PRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDS 1314
               S       +   VA    K L   +       P  GP   AGP  +    ++  ++S
Sbjct: 549  SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608

Query: 1315 LEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSE 1374
              E S  +  S    ++    +A   +  +  PQT  CP +     S +       +++ 
Sbjct: 609  --ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666

Query: 1375 KKARKAMSKLGLRQ-IQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLS 1433
            +KA  A S  G    + G T+   + S +     ++    +   +   V  G+AK     
Sbjct: 667  RKAGTATSPAGSSPAVAGGTQRPAEDSSS-----SEESDSEEEKTGLAVTVGQAKSVGKG 721

Query: 1434 QQVHKAAAEKFK----------VPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1483
             QV KAA+   K          +P +    V +     +   E  EEE + EE       
Sbjct: 722  LQV-KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 1484 ELRDIELVMAQANVSRAKAVRA 1505
                ++   A+AN + A+A  A
Sbjct: 781  VKTSVKKTQAKANPAAARAPSA 802


>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
            [Homo sapiens]
          Length = 1488

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 198/972 (20%), Positives = 339/972 (34%), Gaps = 144/972 (14%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  ----------GLDLP------------SGRKPVAAA-----TIVPRQAEEDLTLPQDSAM 602
                      G  +P            SG+ P  +A     T +  + EE+ ++P   A 
Sbjct: 126  KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185

Query: 603  TPPLPLQDTDLSSAPKPVAAAT----IVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK 658
              P  +      S+ +  ++++    +  + + +   +   SV T   P +     +AP 
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR----KAAPA 241

Query: 659  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ 718
            P      V+ Q + G   P   A  P    + ++  S  +  A A   SQ       L  
Sbjct: 242  PGKVGD-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 778
             +A  P         + AP   A A  V+ Q + G   P++ + +        + S + +
Sbjct: 301  RAASAPAKGTPGKGATPAPPGKAGA--VASQTKAGK--PEEDSES-----SSEESSDSEE 351

Query: 779  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATLVSQQAEEGL 834
               AA  + Q    G T    +A  P         + AP     P  A     ++ E+  
Sbjct: 352  ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 411

Query: 835  TLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPT 894
            +  ++S      P Q      AP+  AA+ P  +   +G          AP P + TGP 
Sbjct: 412  SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAPAPPRKTGPA 462

Query: 895  -------------------SGPEPLAVATPQTLQAEA-GCAPGTEPVATMAQQEVGEALG 934
                               S  +  A+A     Q +  G +P  +P +TM    +G+  G
Sbjct: 463  AAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522

Query: 935  PRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLG--MEALSL 990
            P P P +   A P+  V +     +   ++   +++   P A     + +LG  ++A   
Sbjct: 523  PVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581

Query: 991  PEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETLEVENQQEGGLKPL 1047
              PA G  ++      +   E  +   E+   + D A  DS +        Q +  LK  
Sbjct: 582  SSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAAMTAAQAKPALKIP 639

Query: 1048 AQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVAT 1105
              +  P+  +    A+  P       P  +     SPA     ++G  T  P   S+ + 
Sbjct: 640  QTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG-GTQRPAEDSSSSE 697

Query: 1106 EASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPVL------------ 1146
            E+  DS  E +     VG   S+ +G     A  P      Q   PVL            
Sbjct: 698  ES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVK 755

Query: 1147 -----GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGA 1198
                    S E+  +      +P        +  AK  P+           SAPG +  A
Sbjct: 756  AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTA 815

Query: 1199 ALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPL 1251
            A          ++PP     ++PQ  +V    P     +P     V  AA A +G  +  
Sbjct: 816  AAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVATAAQAQTGPEEDS 868

Query: 1252 GTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQE 1310
            G+    S S   +  L+    S     +   + P  + P      +P G  G SA +  +
Sbjct: 869  GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928

Query: 1311 DEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQ 1370
             +DS          S + SDS GE+ A +    ++ P  +         G   T A+A+ 
Sbjct: 929  QDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQA 980

Query: 1371 SRSEKKARKAMS 1382
            + + +KAR + S
Sbjct: 981  ASTPRKARASES 992



 Score = 81.6 bits (200), Expect = 5e-15
 Identities = 248/1204 (20%), Positives = 419/1204 (34%), Gaps = 166/1204 (13%)

Query: 348  LAGEGEEDSTSASFLQSLSDLSITEGMDEAF---AFRDDTSAASSDSDSASYAEADDERL 404
            L+G+    S   S   +L   +  EG   AF   A     SA  +DS S   + + DE  
Sbjct: 152  LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211

Query: 405  YSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL 464
              G+P  +   ++ S   T+E     A     + G V+  V+       + A   ++ E 
Sbjct: 212  VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA---KKPEE 268

Query: 465  ISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT---RVTPQAGEEETDSTAGQESAA 521
             SE +EEG    +E+ A            LQV  A+   + TP  G+  T +  G+  A 
Sbjct: 269  ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP--GKGATPAPPGKAGAV 326

Query: 522  MAM-----PQPSQEGISEILGQESVTAEKLPTPQE--------ETSLTLCPDSP-QNLKE 567
             +      P+   E  SE   + S + E+ P  +         +TS      +P +    
Sbjct: 327  ASQTKAGKPEEDSESSSE---ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR 383

Query: 568  EGGLDLPSGRK-PVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 626
            +G    P G+  P  A     ++ E+  +  ++S      P Q      AP+  AA+   
Sbjct: 384  KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443

Query: 627  SQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDS-----A 681
             +   +G           P P + T       P AA   V +Q E+  +  ++S     A
Sbjct: 444  KESPRKG---------AAPAPPRKT------GPAAAQVQVGKQEEDSRSSSEESDSDREA 488

Query: 682  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL-------QDTDLS 734
            +      Q   L  +P+   A+T+      +G        + P  P        +D++ S
Sbjct: 489  LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 735  ------SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 788
                  S+   V  A   +Q+   G  L      +P         +  P   A    V  
Sbjct: 549  SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP---------AKGPPQKAGPVAVQV 599

Query: 789  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 848
            +AE+    P D++ +        D   AP  + AA     QA+  L +PQ  A       
Sbjct: 600  KAEK----PMDNSESSEESSDSADSEEAPAAMTAA-----QAKPALKIPQTKACPKK--- 647

Query: 849  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA---PLPLQDTGPTSGPEPLAVATP 905
             +T  S+   PV   T   ++A    +    S   A     P +D+  +   +     T 
Sbjct: 648  TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707

Query: 906  QTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQP 965
              +      + G       A   V  +LG   AP       PTV +  A  + Q+D    
Sbjct: 708  LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA--EKQEDSESS 765

Query: 966  AAEAGTPWAAQEDAD-STLGMEALSLPEPASGAGEEIAEALSRPGR--EACLEARAHTGD 1022
              E+ +  AA   A   T   +  +   PA+         +S PG+   A  +A+  +  
Sbjct: 766  EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825

Query: 1023 GAKPD--SPQKETL------EVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAA---- 1070
              KP   +PQ  T+       V +  +        + GP    G + E  D+   A    
Sbjct: 826  KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLA 885

Query: 1071 ----CPEVSQAR-LLSPAREE-RGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLD 1124
                  +  Q R  L+PA+E  R  +  + P  T PSA       DS         SS +
Sbjct: 886  QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS--------GSSSE 937

Query: 1125 RGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRP 1184
                D  AP +  ++Q  +P L       P+  P+        P    A+ Q ++   + 
Sbjct: 938  ESDSDGEAPAAVTSAQVIKPPL---IFVDPNRSPA-------GPAATPAQAQAASTPRKA 987

Query: 1185 LGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAV 1244
               + +A  + + +    + P   CL    + + V        +      AG   +  + 
Sbjct: 988  RASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESS 1047

Query: 1245 SGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQIL---------PPCQVPPPSGPQ 1295
              +      GP   +S  +P      AS+     AL++L         P  +  P SG  
Sbjct: 1048 RISDGKKQEGPATQVSKKNP------ASLPLTQAALKVLAQKASEAQPPVARTQPSSGVD 1101

Query: 1296 SPAGPQGLSAPE----QQEDEDSLE-------EDSPRALGSGQHSDSHGESSAELDEQDI 1344
            S  G    ++P+    Q +  + L        + + +A  S   S+   +SS+   E+D 
Sbjct: 1102 SAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSG-SEEDG 1160

Query: 1345 LAPQTVQ-CPAQAPAGGSEETIAK--AKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSK 1401
              PQ  +      P     ET+ +  A +S  +     + S L      G+T    Q SK
Sbjct: 1161 EGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK 1220

Query: 1402 NILFVIAKPDVFKSPASDTYVVF---GEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESA 1458
                  A P +  SP+  + +      + K E   QQ     + K       S   P+ +
Sbjct: 1221 ------ATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKS 1274

Query: 1459 PRPR 1462
             +P+
Sbjct: 1275 RKPK 1278



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 155/802 (19%), Positives = 276/802 (34%), Gaps = 91/802 (11%)

Query: 729  QDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 788
            +D  L +    V+     S+ +EE      ++A   P       L+S    V  A + S 
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPR------LASTNSSVLGADLPSS 120

Query: 789  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 848
              E+     + +  T          +S P P    T+ +  + +      + +    L  
Sbjct: 121  MKEKAKAETEKAGKTG---------NSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS 171

Query: 849  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTL 908
            +  +  S P   AAA P    A +  +  +D++ ++     +  P+  P  +  ++  T 
Sbjct: 172  ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231

Query: 909  QAEAG-CAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAA 967
            ++ A   AP    V  +  Q  G AL P    ++        PE  +    +  + +  A
Sbjct: 232  ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK--------PEEESESSEEGSESEEEA 283

Query: 968  EAGTPWAAQEDADSTLGMEALSLPEPAS-GAGEEIAEALSRPGREACLEARAHTGDGAKP 1026
             AGT  +  + ++  L + A S P   + G G   A     PG+   + ++   G   + 
Sbjct: 284  PAGTR-SQVKASEKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTKAGKPEED 338

Query: 1027 DSPQKETLEVENQQEGGLKPL--AQEHGPRSALGGA----REVP-----DAPPAAC-PEV 1074
                 E      ++    K L  A+  G  S +G A    +E P      APP    P V
Sbjct: 339  SESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398

Query: 1075 SQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPT 1134
            ++A+      + +  S +S  E   P+             +S  A  S  +G   AP   
Sbjct: 399  AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458

Query: 1135 SAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGT 1194
            + P + Q +    +G  E+     S          +  A    +    +PLG  P     
Sbjct: 459  TGPAAAQVQ----VGKQEEDSRSSSEESDS-----DREALAAMNAAQVKPLGKSPQVK-- 507

Query: 1195 LAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTG 1254
                       PA  +   P           G+  +PP + G    +A V    +   + 
Sbjct: 508  -----------PASTMGMGPLGK--------GAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 1255 PRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDS 1314
               S       +   VA    K L   +       P  GP   AGP  +    ++  ++S
Sbjct: 549  SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608

Query: 1315 LEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSE 1374
              E S  +  S    ++    +A   +  +  PQT  CP +     S +       +++ 
Sbjct: 609  --ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666

Query: 1375 KKARKAMSKLGLRQ-IQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLS 1433
            +KA  A S  G    + G T+   + S +     ++    +   +   V  G+AK     
Sbjct: 667  RKAGTATSPAGSSPAVAGGTQRPAEDSSS-----SEESDSEEEKTGLAVTVGQAKSVGKG 721

Query: 1434 QQVHKAAAEKFK----------VPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1483
             QV KAA+   K          +P +    V +     +   E  EEE + EE       
Sbjct: 722  LQV-KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 1484 ELRDIELVMAQANVSRAKAVRA 1505
                ++   A+AN + A+A  A
Sbjct: 781  VKTSVKKTQAKANPAAARAPSA 802


>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
            sapiens]
          Length = 1450

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 198/972 (20%), Positives = 339/972 (34%), Gaps = 144/972 (14%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  ----------GLDLP------------SGRKPVAAA-----TIVPRQAEEDLTLPQDSAM 602
                      G  +P            SG+ P  +A     T +  + EE+ ++P   A 
Sbjct: 126  KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185

Query: 603  TPPLPLQDTDLSSAPKPVAAAT----IVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK 658
              P  +      S+ +  ++++    +  + + +   +   SV T   P +     +AP 
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR----KAAPA 241

Query: 659  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ 718
            P      V+ Q + G   P   A  P    + ++  S  +  A A   SQ       L  
Sbjct: 242  PGKVGD-VTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQV 300

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 778
             +A  P         + AP   A A  V+ Q + G   P++ + +        + S + +
Sbjct: 301  RAASAPAKGTPGKGATPAPPGKAGA--VASQTKAGK--PEEDSES-----SSEESSDSEE 351

Query: 779  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATLVSQQAEEGL 834
               AA  + Q    G T    +A  P         + AP     P  A     ++ E+  
Sbjct: 352  ETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ 411

Query: 835  TLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPT 894
            +  ++S      P Q      AP+  AA+ P  +   +G          AP P + TGP 
Sbjct: 412  SSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKG---------AAPAPPRKTGPA 462

Query: 895  -------------------SGPEPLAVATPQTLQAEA-GCAPGTEPVATMAQQEVGEALG 934
                               S  +  A+A     Q +  G +P  +P +TM    +G+  G
Sbjct: 463  AAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAG 522

Query: 935  PRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLG--MEALSL 990
            P P P +   A P+  V +     +   ++   +++   P A     + +LG  ++A   
Sbjct: 523  PVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPT 581

Query: 991  PEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETLEVENQQEGGLKPL 1047
              PA G  ++      +   E  +   E+   + D A  DS +        Q +  LK  
Sbjct: 582  SSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAAMTAAQAKPALKIP 639

Query: 1048 AQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVAT 1105
              +  P+  +    A+  P       P  +     SPA     ++G  T  P   S+ + 
Sbjct: 640  QTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG-GTQRPAEDSSSSE 697

Query: 1106 EASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPVL------------ 1146
            E+  DS  E +     VG   S+ +G     A  P      Q   PVL            
Sbjct: 698  ES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVK 755

Query: 1147 -----GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGA 1198
                    S E+  +      +P        +  AK  P+           SAPG +  A
Sbjct: 756  AEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTA 815

Query: 1199 ALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPL 1251
            A          ++PP     ++PQ  +V    P     +P     V  AA A +G  +  
Sbjct: 816  AAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVATAAQAQTGPEEDS 868

Query: 1252 GTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQE 1310
            G+    S S   +  L+    S     +   + P  + P      +P G  G SA +  +
Sbjct: 869  GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGK 928

Query: 1311 DEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQ 1370
             +DS          S + SDS GE+ A +    ++ P  +         G   T A+A+ 
Sbjct: 929  QDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQA 980

Query: 1371 SRSEKKARKAMS 1382
            + + +KAR + S
Sbjct: 981  ASTPRKARASES 992



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 243/1186 (20%), Positives = 407/1186 (34%), Gaps = 168/1186 (14%)

Query: 348  LAGEGEEDSTSASFLQSLSDLSITEGMDEAF---AFRDDTSAASSDSDSASYAEADDERL 404
            L+G+    S   S   +L   +  EG   AF   A     SA  +DS S   + + DE  
Sbjct: 152  LSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETD 211

Query: 405  YSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQEL 464
              G+P  +   ++ S   T+E     A     + G V+  V+       + A   ++ E 
Sbjct: 212  VEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA---KKPEE 268

Query: 465  ISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT---RVTPQAGEEETDSTAGQESAA 521
             SE +EEG    +E+ A            LQV  A+   + TP  G+  T +  G+  A 
Sbjct: 269  ESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTP--GKGATPAPPGKAGAV 326

Query: 522  MAM-----PQPSQEGISEILGQESVTAEKLPTPQE--------ETSLTLCPDSP-QNLKE 567
             +      P+   E  SE   + S + E+ P  +         +TS      +P +    
Sbjct: 327  ASQTKAGKPEEDSESSSE---ESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPR 383

Query: 568  EGGLDLPSGRK-PVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIV 626
            +G    P G+  P  A     ++ E+  +  ++S      P Q      AP+  AA+   
Sbjct: 384  KGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPA 443

Query: 627  SQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDS-----A 681
             +   +G           P P + T       P AA   V +Q E+  +  ++S     A
Sbjct: 444  KESPRKG---------AAPAPPRKT------GPAAAQVQVGKQEEDSRSSSEESDSDREA 488

Query: 682  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL-------QDTDLS 734
            +      Q   L  +P+   A+T+      +G        + P  P        +D++ S
Sbjct: 489  LAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 735  ------SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 788
                  S+   V  A   +Q+   G  L      +P         +  P   A    V  
Sbjct: 549  SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSP---------AKGPPQKAGPVAVQV 599

Query: 789  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 848
            +AE+    P D++ +        D   AP  + AA     QA+  L +PQ  A       
Sbjct: 600  KAEK----PMDNSESSEESSDSADSEEAPAAMTAA-----QAKPALKIPQTKACPKK--- 647

Query: 849  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTA---PLPLQDTGPTSGPEPLAVATP 905
             +T  S+   PV   T   ++A    +    S   A     P +D+  +   +     T 
Sbjct: 648  TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTG 707

Query: 906  QTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQP 965
              +      + G       A   V  +LG   AP       PTV +  A  + Q+D    
Sbjct: 708  LAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA--EKQEDSESS 765

Query: 966  AAEAGTPWAAQEDAD-STLGMEALSLPEPASGAGEEIAEALSRPGR--EACLEARAHTGD 1022
              E+ +  AA   A   T   +  +   PA+         +S PG+   A  +A+  +  
Sbjct: 766  EEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPS 825

Query: 1023 GAKPD--SPQKETL------EVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAA---- 1070
              KP   +PQ  T+       V +  +        + GP    G + E  D+   A    
Sbjct: 826  KVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEAETLA 885

Query: 1071 ----CPEVSQAR-LLSPAREE-RGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLD 1124
                  +  Q R  L+PA+E  R  +  + P  T PSA       DS         SS +
Sbjct: 886  QVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDS--------GSSSE 937

Query: 1125 RGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRP 1184
                D  AP +  ++Q  +P L       P+  P+        P    A+ Q ++   + 
Sbjct: 938  ESDSDGEAPAAVTSAQVIKPPL---IFVDPNRSPA-------GPAATPAQAQAASTPRKA 987

Query: 1185 LGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPA--AA 1242
               + +A  + + +    + P   CL    + + V        +      AG   +  ++
Sbjct: 988  RASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESS 1047

Query: 1243 AVSGTTQPLGTGPRVSLSPHS-PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQ 1301
             +S   +  G   +V  +  + P  SP+  S+ AK                 P+ P   Q
Sbjct: 1048 RISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKG----------TNKLRKPKLPEVQQ 1097

Query: 1302 GLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1361
               APE  +D +   + S     SG   D  G   A+                  P    
Sbjct: 1098 ATKAPESSDDSEDSSDSS-----SGSEEDGEGPQGAK------------SAHTLGPTPSR 1140

Query: 1362 EETIAK--AKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASD 1419
             ET+ +  A +S  +     + S L      G+T    Q SK      A P +  SP+  
Sbjct: 1141 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASK------ATPKLDSSPSVS 1194

Query: 1420 TYVVF---GEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPR 1462
            + +      + K E   QQ     + K       S   P+ + +P+
Sbjct: 1195 STLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPK 1240



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 155/802 (19%), Positives = 276/802 (34%), Gaps = 91/802 (11%)

Query: 729  QDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQ 788
            +D  L +    V+     S+ +EE      ++A   P       L+S    V  A + S 
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPR------LASTNSSVLGADLPSS 120

Query: 789  QAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL 848
              E+     + +  T          +S P P    T+ +  + +      + +    L  
Sbjct: 121  MKEKAKAETEKAGKTG---------NSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS 171

Query: 849  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTL 908
            +  +  S P   AAA P    A +  +  +D++ ++     +  P+  P  +  ++  T 
Sbjct: 172  ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231

Query: 909  QAEAG-CAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAA 967
            ++ A   AP    V  +  Q  G AL P    ++        PE  +    +  + +  A
Sbjct: 232  ESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKK--------PEEESESSEEGSESEEEA 283

Query: 968  EAGTPWAAQEDADSTLGMEALSLPEPAS-GAGEEIAEALSRPGREACLEARAHTGDGAKP 1026
             AGT  +  + ++  L + A S P   + G G   A     PG+   + ++   G   + 
Sbjct: 284  PAGTR-SQVKASEKILQVRAASAPAKGTPGKGATPAP----PGKAGAVASQTKAGKPEED 338

Query: 1027 DSPQKETLEVENQQEGGLKPL--AQEHGPRSALGGA----REVP-----DAPPAAC-PEV 1074
                 E      ++    K L  A+  G  S +G A    +E P      APP    P V
Sbjct: 339  SESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAV 398

Query: 1075 SQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPT 1134
            ++A+      + +  S +S  E   P+             +S  A  S  +G   AP   
Sbjct: 399  AKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRK 458

Query: 1135 SAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGT 1194
            + P + Q +    +G  E+     S          +  A    +    +PLG  P     
Sbjct: 459  TGPAAAQVQ----VGKQEEDSRSSSEESDS-----DREALAAMNAAQVKPLGKSPQVK-- 507

Query: 1195 LAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTG 1254
                       PA  +   P           G+  +PP + G    +A V    +   + 
Sbjct: 508  -----------PASTMGMGPLGK--------GAGPVPPGKVGPATPSAQVGKWEEDSESS 548

Query: 1255 PRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDS 1314
               S       +   VA    K L   +       P  GP   AGP  +    ++  ++S
Sbjct: 549  SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNS 608

Query: 1315 LEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSE 1374
              E S  +  S    ++    +A   +  +  PQT  CP +     S +       +++ 
Sbjct: 609  --ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666

Query: 1375 KKARKAMSKLGLRQ-IQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLS 1433
            +KA  A S  G    + G T+   + S +     ++    +   +   V  G+AK     
Sbjct: 667  RKAGTATSPAGSSPAVAGGTQRPAEDSSS-----SEESDSEEEKTGLAVTVGQAKSVGKG 721

Query: 1434 QQVHKAAAEKFK----------VPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGL 1483
             QV KAA+   K          +P +    V +     +   E  EEE + EE       
Sbjct: 722  LQV-KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQ 780

Query: 1484 ELRDIELVMAQANVSRAKAVRA 1505
                ++   A+AN + A+A  A
Sbjct: 781  VKTSVKKTQAKANPAAARAPSA 802


>gi|169205253 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 3859

 Score = 82.4 bits (202), Expect = 3e-15
 Identities = 176/780 (22%), Positives = 260/780 (33%), Gaps = 113/780 (14%)

Query: 572  DLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 631
            D P     +A +  VP    +   +P   A  P +P+   D    P   A   IVS    
Sbjct: 604  DSPVLSVTLADSPAVPVTPADSPVVPVTPADGPVVPVASADSPFVPVTPADDPIVSVTPA 663

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 691
            E   +P     +P +P+   +    P   A   +V   A     +P   A TP  P+   
Sbjct: 664  ESPAIPVTQADSPVVPVTSADRPVIPVTTADGRIVPVTAAGDPIVPVTPADTPGSPVTSA 723

Query: 692  D-----LSSAPKPVAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSA 736
            D     ++SA  P    T     +V   + +G   P  SA  P +P+   D     +SSA
Sbjct: 724  DGPVVPVTSADSPFVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTSADGPVAPVSSA 783

Query: 737  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL 796
              PV   T        G  +P  SA +P +P+   D    P   A   IV     +   +
Sbjct: 784  DGPVVPVTPAD---TNGPAVPVTSADSPFVPVIPADSPVVPVTPADDPIVPVTPADSSFV 840

Query: 797  PQDSAMTPPLPL----------QDTDLSSAPKPVAAATLVSQQAEEGLT--LPQDS---A 841
            P  SA +P +P+            TD+   P       LV   A+E +    P DS    
Sbjct: 841  PVISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETVVPLNPADSPVIP 900

Query: 842  MTPP----LPLQDTD-----LSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTG 892
            +TPP    +P+  TD     ++SA  PV   TP    A+     P  +A    +P     
Sbjct: 901  VTPPDDLVVPVTPTDCPVAPVTSADCPVVPVTPADSPAD-----PVTAADGPVVPF---- 951

Query: 893  PTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEP 952
             T   +P+   TP          P   PV  +A                 +A  P VP  
Sbjct: 952  -TPADDPIVPVTPAD-SPVVSVTPADGPVVPVA-----------------SADSPFVPVT 992

Query: 953  AALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREA 1012
             A D +    P     A +P      ADS +         P + A   ++   +  GR  
Sbjct: 993  PADDPIVSVTP-----AESPAIPVTQADSPV--------VPVTSADRPVSPVTTADGRIV 1039

Query: 1013 CLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACP 1072
             + A    GD   P +P           +G + P+     P         VP  PP   P
Sbjct: 1040 PVTA---AGDPIVPVTPADTPGSPVTSADGPVVPVTSADSP--------FVPVTPPDG-P 1087

Query: 1073 EVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPA 1132
             V       P        G   P  +    VA  +S D      V  V+  D   P  P 
Sbjct: 1088 VVPVTSADGPVAPVSSADGPVVPVTSADGPVAPVSSAD----GPVVPVTPAD--SPFIPV 1141

Query: 1133 PTS----APTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPD 1188
             T+     P +    PVL +   + P    +   +P++  P       P +  D P  P 
Sbjct: 1142 TTADDPIVPVTPADSPVLSVTLADSPVVPVTPADSPVIPVPPANGPVVPVSSADSPFVPV 1201

Query: 1189 PSAPGTL-----AGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLP--PPQAGVQPAA 1241
              A G +         + P+ P    L  D  +D V       S  +P  P  + V P  
Sbjct: 1202 IPADGLVVLDSSTDVLVVPVSPTDGILVPDLADDPVVSVTIADSPVIPVTPADSPVVPVT 1261

Query: 1242 AAVSGTTQPL-GTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGP 1300
            +A S          P + ++P  P++S   A      ++    P   V     P  P  P
Sbjct: 1262 SADSPVVPVTPADSPVILVTPVGPVVSVTTADGPVVLVSTADSPVIPVTSADSPVVPVTP 1321



 Score = 80.9 bits (198), Expect = 9e-15
 Identities = 172/772 (22%), Positives = 264/772 (34%), Gaps = 121/772 (15%)

Query: 572  DLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAE 631
            D P     +A + +VP    +   +P   A  P +P+   D    P   A   +VS  + 
Sbjct: 334  DSPVLSVTLADSPVVPVTPADSPFVPAIPADGPVVPVTPADSPVVPVTPADGPVVSVASA 393

Query: 632  EGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDT 691
            +   +P      P + +   +    P   A + L+     +G  +P  +A  P +P+   
Sbjct: 394  DSPFVPVTPADDPIVSVTPADSPVVPVTSADSPLIPVTTADGRVVPVTAAGDPIVPVTPA 453

Query: 692  D-----LSSAPKPVAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 741
            D     ++SA  PV   T     LV     +G  +P  SA  P  P+   D    P   A
Sbjct: 454  DTPGSPVTSADGPVVPVTSADIPLVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTPA 513

Query: 742  AATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSA 801
             +  +     + L +P   A +P L +   +  + P   A + IV      G  +P  SA
Sbjct: 514  DSPFIPVTTADDLIVPVTPADSPVLSVTPAESPAIPVTPADSPIVPVTPANGPVVPVTSA 573

Query: 802  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 861
             +P +P+   D    P   A + +V     +   L    A +P +P+   D      PV 
Sbjct: 574  DSPFVPVIPADGPVVPVTPADSPVVPVTPADSPVLSVTLADSPAVPVTPAD-----SPVV 628

Query: 862  AATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTE-- 919
              TP      +G  +P  SA +  +P+     T   +P+   TP    AE+   P T+  
Sbjct: 629  PVTPA-----DGPVVPVASADSPFVPV-----TPADDPIVSVTP----AESPAIPVTQAD 674

Query: 920  -PVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQED 978
             PV  +   +       RP      A    VP  AA D +      P   A TP +    
Sbjct: 675  SPVVPVTSAD-------RPVIPVTTADGRIVPVTAAGDPI-----VPVTPADTPGSPVTS 722

Query: 979  ADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVEN 1038
            AD  +         P + A                            P +P    +    
Sbjct: 723  ADGPV--------VPVTSADSPFV-----------------------PVTPPDGPVVPVT 751

Query: 1039 QQEGGLKPLAQEHGP----RSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKST 1094
              +G + P++   GP     SA G    V  A     P V+ A    PA           
Sbjct: 752  SADGPVAPVSSADGPVVPVTSADGPVAPVSSADGPVVP-VTPADTNGPAVPVTSADSPFV 810

Query: 1095 P-----EPTLPSAVATEASLDSCP-ESSVGAVSSLDRGC-----PDAPAPTSAPTSQQPE 1143
            P      P +P   A +  +   P +SS   V S D         D P    + T     
Sbjct: 811  PVIPADSPVVPVTPADDPIVPVTPADSSFVPVISADSPFVPVIPADGPVVVDSSTDVLVV 870

Query: 1144 PVLGLGSVEQPHEVPSVLGTPL---------LQPPENLAKGQPSTPVDRPLGPDPSA--- 1191
            PV  +  +  P      +  PL         + PP++L    P TP D P+ P  SA   
Sbjct: 871  PVFPVNCILVPAFADETV-VPLNPADSPVIPVTPPDDLV--VPVTPTDCPVAPVTSADCP 927

Query: 1192 --PGTLAGAALPPL-EPPAPCLCQDPQEDSVEDEEPPGS--LGLPPPQAGVQPAAAAVSG 1246
              P T A +   P+     P +   P +D +    P  S  + + P    V P A+A S 
Sbjct: 928  VVPVTPADSPADPVTAADGPVVPFTPADDPIVPVTPADSPVVSVTPADGPVVPVASADS- 986

Query: 1247 TTQPLGTGPRVSLSP-HSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSP 1297
                    P V ++P   P++S   A   A  +     P   V     P SP
Sbjct: 987  --------PFVPVTPADDPIVSVTPAESPAIPVTQADSPVVPVTSADRPVSP 1030



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 171/792 (21%), Positives = 263/792 (33%), Gaps = 90/792 (11%)

Query: 560  DSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTD-----LS 614
            DSP         D P      A   +VP  + + L +P   A  P +P+   D     +S
Sbjct: 1712 DSPVVPVTSADTDSPGSPVTSADGPVVPVTSADSLPVPVTPADGPVVPVTSADGPVAPVS 1771

Query: 615  SAPKPVAAAT-----IVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQ 669
            SA  PV   T     +V     +  T+P     +P +P+        P   A +  V   
Sbjct: 1772 SADGPVVPVTPADSPVVPVTTADDPTVPVTPADSPVVPVPPANGPIVPVTSADSPFVPVI 1831

Query: 670  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 729
              +GL +   S     +P+  TD    P  +A   +VS    +   +P   A +P + + 
Sbjct: 1832 PADGLVVLDSSTDVLVVPVSPTDGILVP-DLADDPVVSVTIADSPVIPVTPADSPVVLVT 1890

Query: 730  DTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 789
              D    P       +V     +   +P      P +P+   D    P   A + IVS  
Sbjct: 1891 PADGPVVPVTSVDNPVVPVTPADNPVIPVTPVDDPVVPVTPADDPIVPVTSADSPIVSVT 1950

Query: 790  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 849
              +    P   A +P +P+   D    P   A   +V     +G  +P   A +P +P+ 
Sbjct: 1951 PADSPVFPVTPADSPVIPVASADSPLVPVTPADMVVVPVIPADGPVIPVTPAESPAIPVT 2010

Query: 850  DTD-----LSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVAT 904
             TD     ++SA  PV    PV+  +      P DS +    P  D      P    V  
Sbjct: 2011 PTDSPVVPVTSADSPV---IPVTADSPFVPVTPADSPVIPVTPPDDLVVPVTPIDCPV-V 2066

Query: 905  PQTLQ--AEAGCAPGTEPVATMAQQE-----VGEALGP-RPAPEEKNAALPTVPEPAALD 956
            P TL         P   PV  +   +     V  A  P  P     +  +P  P  + + 
Sbjct: 2067 PVTLVDCPVVSVTPANSPVDPVTPADGPVVPVTPADSPVIPVTPADDLIVPVTPADSLIV 2126

Query: 957  QVQQDDPQ--PAAEAGTPWAAQEDADSTL----GMEALSLP-EPASGAGEEIAEALSRPG 1009
             V   D    P   A +P  +   ADS +      + + +P  PA G    +  A S   
Sbjct: 2127 SVTPADSPVVPVTPADSPVISVASADSPVVPVTPADTVVVPVTPADGPVIPVTPAES--- 2183

Query: 1010 REACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPA 1069
                          A P +P    +      +  + P+     P         +   PPA
Sbjct: 2184 -------------PAIPVTPADSPVVPVTPADDPVVPVTPADSP---------IVPVPPA 2221

Query: 1070 ACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPD 1129
            + P V      +P        G   P  +  S +      DS P   V    S       
Sbjct: 2222 SDPVVPVTPADTPGSPVASADGPVVPVTSADSPLVPVTPGDS-PVVPVTPADSPVFPVTS 2280

Query: 1130 APAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDP 1189
            A  P   P +   +PV  +   + P    S   +P++          P TP + P+ P P
Sbjct: 2281 ADGPV-FPVTLADDPVFPVTPADDPIFPVSPADSPVV----------PVTPANIPVVPVP 2329

Query: 1190 SA-----PGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAV 1244
             A     P T AG+   P+ P    +  D   D +     P   G+P P     P  +  
Sbjct: 2330 PANGSVVPVTSAGSPFVPIIPADGLVVLDSSTDVLVVLVSPTD-GIPVPDLADDPVVSVT 2388

Query: 1245 SGTTQPLGTGPRVS-LSPHSPLLSP--KVASMDAKDLALQILPPCQVPPPSGPQSPAGP- 1300
            +  +  +   P  S + P +P   P   V S+D+        P   V P   P  P  P 
Sbjct: 2389 TSDSPVIPVTPTDSPVVPVAPADGPVVPVTSVDS--------PVVPVTPADSPVIPVTPA 2440

Query: 1301 QGLSAPEQQEDE 1312
              L  P    D+
Sbjct: 2441 DSLVVPATPADD 2452



 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 185/836 (22%), Positives = 282/836 (33%), Gaps = 125/836 (14%)

Query: 548  TPQEETSLTLCPDS----PQNLKEEGGLDLPSGRKPVAAAT-----IVPRQAEEDLTLPQ 598
            TP ++  +++ P      P    +   + + S  +PV+  T     IVP  A  D  +P 
Sbjct: 992  TPADDPIVSVTPAESPAIPVTQADSPVVPVTSADRPVSPVTTADGRIVPVTAAGDPIVPV 1051

Query: 599  DSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK 658
              A TP  P+   D    P   A +  V     +G  +P  S   P  P+   +    P 
Sbjct: 1052 TPADTPGSPVTSADGPVVPVTSADSPFVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPV 1111

Query: 659  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ 718
              A   +    + +G  +P   A +P +P+   D    P   A + ++S    +   +P 
Sbjct: 1112 TSADGPVAPVSSADGPVVPVTPADSPFIPVTTADDPIVPVTPADSPVLSVTLADSPVVPV 1171

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 778
              A +P +P+   +    P   A +  V     +GL +   S     +P+  TD    P 
Sbjct: 1172 TPADSPVIPVPPANGPVVPVSSADSPFVPVIPADGLVVLDSSTDVLVVPVSPTDGILVP- 1230

Query: 779  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAAT----LVSQQ 829
             +A   +VS    +   +P   A +P +P+   D     ++ A  PV   T    +VS  
Sbjct: 1231 DLADDPVVSVTIADSPVIPVTPADSPVVPVTSADSPVVPVTPADSPVILVTPVGPVVSVT 1290

Query: 830  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQ 889
              +G  +   +A +P +P     ++SA  PV   TP      +G  +P  SA +  +P+ 
Sbjct: 1291 TADGPVVLVSTADSPVIP-----VTSADSPVVPVTPA-----DGPVVPVTSADSPFVPV- 1339

Query: 890  DTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTV 949
                T   +P+   TP          P   P   +   +        P     +A  P +
Sbjct: 1340 ----TPADDPIVPVTPAD-SPIVSVTPAESPAIPVTPAD-------SPVVPVTSADSPLI 1387

Query: 950  PEPAALDQVQQDDPQ-----PAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEA 1004
            P   A  +V    P      P   A TP +    AD  +         P + AG+ I   
Sbjct: 1388 PLTTAGSRVVPVTPTGDPIVPVTPADTPGSPVTSADGPV--------VPVTPAGDPIVPV 1439

Query: 1005 --LSRPGREACLE----ARAHTGDG-AKPDSPQKETLEVENQQEGGLKPLAQEHGPRSAL 1057
                 PG              T DG   P SP    +      +G + P+     P   +
Sbjct: 1440 TPADTPGSPVTSADGPVVPVTTPDGPLVPVSPPDGPVVPVTSADGPVVPVTPADSPFIPV 1499

Query: 1058 GGARE--VPDAP---------PAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATE 1106
              A +  VP  P         PA  P V       P            P       VA +
Sbjct: 1500 TTADDPIVPVTPADSPVVPVTPADIPVVPVTPANGPVIHVTSADCPFVPVIPADGLVALD 1559

Query: 1107 ASLD---------------SCPESSVGAVSSLDRG-CPDAPA-PTSAPTSQQPEPVLGLG 1149
            +S D                  +  V +V+  D    P  PA  T  P +    PV+ + 
Sbjct: 1560 SSTDVLVVPVSPTDGVLVPDLADDPVVSVTIADSPVIPVTPADSTVVPVTLADGPVVPVT 1619

Query: 1150 SVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPC 1209
            SV    ++P V  TP   P        P TPVD P+     A G++    +P      P 
Sbjct: 1620 SV----DIPVVPVTPANGPV------APVTPVDDPVVSVNPADGSV----VPVTSADCPV 1665

Query: 1210 LCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSL---------- 1259
            +   P +  V    P  S  +P   A   P     S  +  +   P  S           
Sbjct: 1666 VPVTPADGLVVPVTPADSPIVPVTPAD-SPVVLVTSADSPVIPVTPADSPVVPVTSADTD 1724

Query: 1260 SPHSPLLS---PKVASMDAKDLALQILPPCQVPPPSGPQSP-AGPQGLSAPEQQED 1311
            SP SP+ S   P V    A  L      P  V P  GP  P     G  AP    D
Sbjct: 1725 SPGSPVTSADGPVVPVTSADSL------PVPVTPADGPVVPVTSADGPVAPVSSAD 1774



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 168/768 (21%), Positives = 255/768 (33%), Gaps = 89/768 (11%)

Query: 585  IVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTP 644
            +VP    +DL  P   A +P +P+   D    P   A   +V   +  G  +P     +P
Sbjct: 88   VVPVTPADDLVFPVTPADSPVIPVTSADDPVVPITPADNPVVPVTSANGPVIPVTPADSP 147

Query: 645  PLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 704
              P+   +    P   A + +      +    P   A +P  P+   D ++ P   A   
Sbjct: 148  VFPVASADGPVVPVTPADSPVFPVTPADSPLFPVTPADSPLFPVTPADSAAIPVTPADGP 207

Query: 705  LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTP 764
            +V      G  +P   A +P + +  TD    P   A   +V     +   +P  SA +P
Sbjct: 208  VVHVTPANGTVVPVTPADSPVVTVASTDSPVVPVTPADDPIVPVTPADSSFVPVISADSP 267

Query: 765  PLPL----------QDTDLSSAPK-PV--------AAATIVSQQAEEGLTLPQDSAMTPP 805
             +P+            TD+   P  PV        A  TI        L +   +A  P 
Sbjct: 268  FVPVIPADGPVVVDSSTDVLVVPVFPVNCILVPAFADETIXXXXXXXSLVVSVTTADDPI 327

Query: 806  LPLQDTD-----LSSAPKPVAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTD--- 852
            +P+   D     ++ A  PV   T      V     +G  +P   A +P +P+   D   
Sbjct: 328  VPVTPADSPVLSVTLADSPVVPVTPADSPFVPAIPADGPVVPVTPADSPVVPVTPADGPV 387

Query: 853  --LSSAPKPVAAATP-----VSQQAEEGLTLPQDSAMTAPLPLQDTG-----PTSGPEPL 900
              ++SA  P    TP     VS    +   +P  SA +  +P+          T+  +P+
Sbjct: 388  VSVASADSPFVPVTPADDPIVSVTPADSPVVPVTSADSPLIPVTTADGRVVPVTAAGDPI 447

Query: 901  AVATPQTLQAEAGCAPGTE---PVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQ 957
               TP    A+   +P T    PV  +   ++   L P   P+     + +   P A   
Sbjct: 448  VPVTP----ADTPGSPVTSADGPVVPVTSADI--PLVPVTPPDGPVVPVTSADGPVAPVS 501

Query: 958  VQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEAR 1017
                   P   A +P+     AD         L  P + A   +   LS    E+     
Sbjct: 502  SADGPVVPVTPADSPFIPVTTAD--------DLIVPVTPADSPV---LSVTPAESPAIPV 550

Query: 1018 AHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGA-REVPDAPPAACPEVSQ 1076
                    P +P    +      +    P+    GP   +  A   V    PA  P +S 
Sbjct: 551  TPADSPIVPVTPANGPVVPVTSADSPFVPVIPADGPVVPVTPADSPVVPVTPADSPVLSV 610

Query: 1077 ARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSA 1136
                SPA           P       V   AS DS     V    + D      PA + A
Sbjct: 611  TLADSPAVPVTPADSPVVPVTPADGPVVPVASADS---PFVPVTPADDPIVSVTPAESPA 667

Query: 1137 -PTSQQPEPVLGLGSVEQP---------HEVP-SVLGTPLLQPPENLAKGQPSTPVDRPL 1185
             P +Q   PV+ + S ++P           VP +  G P++        G P T  D P+
Sbjct: 668  IPVTQADSPVVPVTSADRPVIPVTTADGRIVPVTAAGDPIVPVTPADTPGSPVTSADGPV 727

Query: 1186 GPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPP--GSLGLPPPQAGVQPAAAA 1243
             P  SA         PP  P  P    D     V   + P         P A V  A   
Sbjct: 728  VPVTSADSPFV-PVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTSADGPVAPVSSADGP 786

Query: 1244 VSGTTQPLGTGPRVSL----SPHSPLL---SPKVASMDAKDLALQILP 1284
            V   T     GP V +    SP  P++   SP V    A D  + + P
Sbjct: 787  VVPVTPADTNGPAVPVTSADSPFVPVIPADSPVVPVTPADDPIVPVTP 834



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 164/777 (21%), Positives = 252/777 (32%), Gaps = 93/777 (11%)

Query: 585  IVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTP 644
            +VP    + + +P D A  P + +   D    P   A +T+V     +G  +P  SV  P
Sbjct: 1566 VVPVSPTDGVLVP-DLADDPVVSVTIADSPVIPVTPADSTVVPVTLADGPVVPVTSVDIP 1624

Query: 645  PLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKP 699
             +P+       AP       +VS    +G  +P  SA  P +P+   D     ++ A  P
Sbjct: 1625 VVPVTPANGPVAPVTPVDDPVVSVNPADGSVVPVTSADCPVVPVTPADGLVVPVTPADSP 1684

Query: 700  VAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT---------- 744
            +   T     +V   + +   +P   A +P +P+   D  S   PV +A           
Sbjct: 1685 IVPVTPADSPVVLVTSADSPVIPVTPADSPVVPVTSADTDSPGSPVTSADGPVVPVTSAD 1744

Query: 745  --LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM 802
               V     +G  +P  SA  P  P+   D    P   A + +V     +  T+P   A 
Sbjct: 1745 SLPVPVTPADGPVVPVTSADGPVAPVSSADGPVVPVTPADSPVVPVTTADDPTVPVTPAD 1804

Query: 803  TPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 862
            +P +P+   +    P   A +  V     +GL +   S     +P+  TD    P  +A 
Sbjct: 1805 SPVVPVPPANGPIVPVTSADSPFVPVIPADGLVVLDSSTDVLVVPVSPTDGILVP-DLAD 1863

Query: 863  ATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVA 922
               VS    +   +P      A  P+    P  GP    V             P   PV 
Sbjct: 1864 DPVVSVTIADSPVIP---VTPADSPVVLVTPADGP---VVPVTSVDNPVVPVTPADNPVI 1917

Query: 923  TMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADST 982
             +    V + + P    ++    + +   P            P   A +P      ADS 
Sbjct: 1918 PVT--PVDDPVVPVTPADDPIVPVTSADSPIVSVTPADSPVFPVTPADSPVIPVASADSP 1975

Query: 983  LGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKP-DSPQKETLEVENQQE 1041
            L         P + A   +   +   G    +           P DSP    + V +   
Sbjct: 1976 L--------VPVTPADMVVVPVIPADGPVIPVTPAESPAIPVTPTDSP---VVPVTSADS 2024

Query: 1042 GGLKPLAQEHGPRSALGGAREVPDAPP-------------------AACPEVSQARLLSP 1082
              +   A           +  +P  PP                     CP VS     SP
Sbjct: 2025 PVIPVTADSPFVPVTPADSPVIPVTPPDDLVVPVTPIDCPVVPVTLVDCPVVSVTPANSP 2084

Query: 1083 AREERGLSGKSTP-----EPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAP 1137
                    G   P      P +P   A +  +   P  S+  + S+     D+P     P
Sbjct: 2085 VDPVTPADGPVVPVTPADSPVIPVTPADDLIVPVTPADSL--IVSVTPA--DSPV---VP 2137

Query: 1138 TSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQ--PSTPVDRPLGP-----DPS 1190
             +    PV+ + S + P  V  V     +  P   A G   P TP + P  P      P 
Sbjct: 2138 VTPADSPVISVASADSP--VVPVTPADTVVVPVTPADGPVIPVTPAESPAIPVTPADSPV 2195

Query: 1191 APGTLAGAALPPLEP-PAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQ 1249
             P T A   + P+ P  +P +   P  D V    P  + G   P A        V+    
Sbjct: 2196 VPVTPADDPVVPVTPADSPIVPVPPASDPVVPVTPADTPG--SPVASADGPVVPVTSADS 2253

Query: 1250 PL-----GTGPRVSLSP-HSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGP 1300
            PL     G  P V ++P  SP+     A      + L   P   V P   P  P  P
Sbjct: 2254 PLVPVTPGDSPVVPVTPADSPVFPVTSADGPVFPVTLADDPVFPVTPADDPIFPVSP 2310



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 165/795 (20%), Positives = 262/795 (32%), Gaps = 108/795 (13%)

Query: 581  AAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 640
            A + ++P    +DL +P      P +P+   D        A + +      +G  +P   
Sbjct: 2041 ADSPVIPVTPPDDLVVPVTPIDCPVVPVTLVDCPVVSVTPANSPVDPVTPADGPVVPVTP 2100

Query: 641  VMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPV 700
              +P +P+   +    P   A + +VS    +   +P   A +P + +   D    P   
Sbjct: 2101 ADSPVIPVTPADDLIVPVTPADSLIVSVTPADSPVVPVTPADSPVISVASADSPVVPVTP 2160

Query: 701  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 760
            A   +V     +G  +P   A +P +P+   D    P   A   +V     +   +P   
Sbjct: 2161 ADTVVVPVTPADGPVIPVTPAESPAIPVTPADSPVVPVTPADDPVVPVTPADSPIVPVPP 2220

Query: 761  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTD-----LSS 815
            A  P +P+   D   +P   A   +V   + +   +P     +P +P+   D     ++S
Sbjct: 2221 ASDPVVPVTPADTPGSPVASADGPVVPVTSADSPLVPVTPGDSPVVPVTPADSPVFPVTS 2280

Query: 816  APKPVAAATLVSQQA-----EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA--AATPVSQ 868
            A  PV   TL           +    P   A +P +P+   ++   P P A  +  PV+ 
Sbjct: 2281 ADGPVFPVTLADDPVFPVTPADDPIFPVSPADSPVVPVTPANIPVVPVPPANGSVVPVTS 2340

Query: 869  QAE--------EGLTLPQDS--------AMTAPLPLQD------TGPTSGPEPLAVATPQ 906
                       +GL +   S        + T  +P+ D         T+   P+   TP 
Sbjct: 2341 AGSPFVPIIPADGLVVLDSSTDVLVVLVSPTDGIPVPDLADDPVVSVTTSDSPVIPVTP- 2399

Query: 907  TLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVP-EPAALDQVQQDDP-- 963
            T       AP   PV  +   +        P     +  +P  P +   +     DDP  
Sbjct: 2400 TDSPVVPVAPADGPVVPVTSVDSPVV----PVTPADSPVIPVTPADSLVVPATPADDPVV 2455

Query: 964  ---------QPAAEAGTPWAAQEDADSTLGMEALSLP-EPASGAGEEIAEALSRPGREAC 1013
                      P   A  P  +   ADS +      +P  PA G    +  A      ++ 
Sbjct: 2456 SVTPADGPVVPVTTADIPVISVTSADSPV------VPVTPADGLVVPVTSA------DSV 2503

Query: 1014 LEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGA-REVPDAPPAACP 1072
            +           P  P    + +    +  +  +  +  P   +  A   V    PA  P
Sbjct: 2504 VVPATPADCPLVPVDPADSPIVLFTPYDNPVVSVTSDDSPVFPVTPADSSVVPVTPAGVP 2563

Query: 1073 EVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGC-PDAP 1131
             V     ++P        G   P     S V    S D    S V  V+  D    P +P
Sbjct: 2564 VVP----VTPG------DGPVVPVTPADSLVVPVTSAD----SPVFPVTPADSPVFPVSP 2609

Query: 1132 A-PTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQP--PENLAKGQ--PSTPVDRPLG 1186
            A     P +    PV+ +     P + P VL TP   P  P   A G   P T  D P  
Sbjct: 2610 ADDLVVPVTPGDSPVVPV----SPADSPVVLVTPADGPVVPVTPANGPVVPVTSADSPFV 2665

Query: 1187 PDPSAPGTL-----AGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAA 1241
            P   A G +         + P+ P    L  D  +D V     PG   + P   G  P  
Sbjct: 2666 PVIPADGLVVLDSSTDVLVVPVFPTDGILVPDLADDPVV-PVTPGDDPVVPVTPGDDPVI 2724

Query: 1242 AAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQ 1301
                    P   GP V   P +P + P V  + A D    ++P      P     P    
Sbjct: 2725 PVT-----PADDGPFV---PVTPAVGPVVPDLTADD---SVVPDSLTDDPVISVCP--DD 2771

Query: 1302 GLSAPEQQEDEDSLE 1316
            GL  P+   D D  E
Sbjct: 2772 GLVVPDTVRDSDGPE 2786



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 172/864 (19%), Positives = 288/864 (33%), Gaps = 132/864 (15%)

Query: 548  TPQEETSLTLCP-DSPQNLKEEGGLDLPSGRKPVAAATIV-----PRQAEEDLTLPQDSA 601
            TP ++  + + P DSP        + +P    PV   T       P  + +   +P  SA
Sbjct: 2199 TPADDPVVPVTPADSPI-------VPVPPASDPVVPVTPADTPGSPVASADGPVVPVTSA 2251

Query: 602  MTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLP---QDSVMTPPLPLQDT--ELSSA 656
             +P +P+   D    P   A + +    + +G   P    D  + P  P  D    +S A
Sbjct: 2252 DSPLVPVTPGDSPVVPVTPADSPVFPVTSADGPVFPVTLADDPVFPVTPADDPIFPVSPA 2311

Query: 657  PKPVAAAT-----LVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAE 711
              PV   T     +V      G  +P  SA +P +P+   D            +V     
Sbjct: 2312 DSPVVPVTPANIPVVPVPPANGSVVPVTSAGSPFVPIIPADGLVVLDSSTDVLVVLVSPT 2371

Query: 712  EGLTLPQ---------DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAM 762
            +G+ +P           ++ +P +P+  TD    P   A   +V   + +   +P   A 
Sbjct: 2372 DGIPVPDLADDPVVSVTTSDSPVIPVTPTDSPVVPVAPADGPVVPVTSVDSPVVPVTPAD 2431

Query: 763  TPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA 822
            +P +P+   D    P   A   +VS    +G  +P  +A  P + +   D    P   A 
Sbjct: 2432 SPVIPVTPADSLVVPATPADDPVVSVTPADGPVVPVTTADIPVISVTSADSPVVPVTPAD 2491

Query: 823  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATP-----VSQQAEEGLTLP 877
              +V   + + + +P   A  P +P+   D      P+   TP     VS  +++    P
Sbjct: 2492 GLVVPVTSADSVVVPATPADCPLVPVDPAD-----SPIVLFTPYDNPVVSVTSDDSPVFP 2546

Query: 878  QDSAMTAPLPLQDTG-----PTSGPEPLAVATP------QTLQAEAGCAPGTE------P 920
               A ++ +P+   G      T G  P+   TP          A++   P T       P
Sbjct: 2547 VTPADSSVVPVTPAGVPVVPVTPGDGPVVPVTPADSLVVPVTSADSPVFPVTPADSPVFP 2606

Query: 921  VATMAQQEVGEALGPRP----APEEKNAALPTVPEPAALDQVQQDDP-QPAAEAGTPWAA 975
            V+      V    G  P    +P +    L T  +   +     + P  P   A +P+  
Sbjct: 2607 VSPADDLVVPVTPGDSPVVPVSPADSPVVLVTPADGPVVPVTPANGPVVPVTSADSPFVP 2666

Query: 976  QEDADSTLGMEALS--LPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKE- 1032
               AD  + +++ +  L  P       +   L+    +  +       D   P +P  + 
Sbjct: 2667 VIPADGLVVLDSSTDVLVVPVFPTDGILVPDLA----DDPVVPVTPGDDPVVPVTPGDDP 2722

Query: 1033 TLEVENQQEGGLKPLAQEHGP--RSALGGAREVPDAPP-----AACPEVSQARLLSPARE 1085
             + V    +G   P+    GP           VPD+       + CP+      L     
Sbjct: 2723 VIPVTPADDGPFVPVTPAVGPVVPDLTADDSVVPDSLTDDPVISVCPDDG----LVVPDT 2778

Query: 1086 ERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPT----------- 1134
             R   G       +   V T+++ D CP  SV     L   CP    P            
Sbjct: 2779 VRDSDGPEVSVYPVTGPVVTDSAAD-CPVVSVPLTDGLVVLCPPDEVPAVHDSVTNGLVV 2837

Query: 1135 -----SAPTSQQPE---PVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVD---- 1182
                   P    P    P++ + S + P     +   P++  P   +    STP D    
Sbjct: 2838 PDPVIDGPVFSNPSVDGPIVPVASADNPGVPDPIRAFPVVPKPSTFSPVVTSTPADWIDV 2897

Query: 1183 --RPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEP------------PGSL 1228
               P          + G  +P L    P +   P +D V    P             G +
Sbjct: 2898 IVTPADCADVPVNPVNGPVVPDLSGDCPVVPVPPTDDIVVLNPPDVVFAVVSTPVTDGPV 2957

Query: 1229 GLPPPQAGVQPAAAAVSGTTQP--LGTGPRVSLSPH-----SPLLSPKVASMDAKDLALQ 1281
               P   G+       +G+  P  L   P V+++P      SP +   V    + D ++ 
Sbjct: 2958 VTDPATDGLMVPVTPANGSVAPVTLSEYPDVTVTPADGTVVSPTIGGPVVPDPSADSSVV 3017

Query: 1282 ILPPCQ---VPPP--SGPQSPAGP 1300
              P      VP P  +GP  P  P
Sbjct: 3018 SNPTTDGLIVPNPLLAGPVVPVTP 3041



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 169/836 (20%), Positives = 285/836 (34%), Gaps = 136/836 (16%)

Query: 532  ISEILGQESVTAEKLPTPQEETSLTLCPDS----PQNLKEEGGLDLPSGRKPVAAATIVP 587
            + ++   +SV  + L    ++  +++CPD     P  +++  G ++     PV    +  
Sbjct: 2745 VPDLTADDSVVPDSLT---DDPVISVCPDDGLVVPDTVRDSDGPEVSV--YPVTGPVVTD 2799

Query: 588  RQAE-EDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPL 646
              A+   +++P    +    P    ++ +    V    +V     +G      SV  P +
Sbjct: 2800 SAADCPVVSVPLTDGLVVLCP--PDEVPAVHDSVTNGLVVPDPVIDGPVFSNPSVDGPIV 2857

Query: 647  PLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLV 706
            P+   +    P P+ A  +V          P+ S  +P +     D        A    V
Sbjct: 2858 PVASADNPGVPDPIRAFPVV----------PKPSTFSPVVTSTPADWIDVIVTPADCADV 2907

Query: 707  SQQAEEGLTLPQDSAMTPPLPLQDTD-----------LSSAPKPVAAATLVSQQAEEGLT 755
                  G  +P  S   P +P+  TD            +    PV    +V+  A +GL 
Sbjct: 2908 PVNPVNGPVVPDLSGDCPVVPVPPTDDIVVLNPPDVVFAVVSTPVTDGPVVTDPATDGLM 2967

Query: 756  LPQDSAMTPPLPLQ-----DTDLSSA--------------PKPVAAATIVSQQAEEGLTL 796
            +P   A     P+      D  ++ A              P P A +++VS    +GL +
Sbjct: 2968 VPVTPANGSVAPVTLSEYPDVTVTPADGTVVSPTIGGPVVPDPSADSSVVSNPTTDGLIV 3027

Query: 797  PQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 856
            P      P +P+  TD   AP  +A    V+    +G  +   +   P  P    +    
Sbjct: 3028 PNPLLAGPVVPVTPTDGPLAPVILADCPDVTVTPADGPVVCAFTTGGPVFPDPTAEGLVV 3087

Query: 857  PKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAP 916
              P      V+  + +GL     SA  A        P   P+ L       L  ++    
Sbjct: 3088 SNPTVDDPVVTNPSTKGLV----SATPADCADVPVIPADCPDVLV-----NLVNDSVVPD 3138

Query: 917  GTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQ 976
             T     ++     + + P P  E     +P    P   D            AG P    
Sbjct: 3139 FTADWTVVSVSPPDDLVAPDPPDEVPVVLVPITDGPVVPDLTTDGLVVSVTPAGAPVVPV 3198

Query: 977  EDAD----STLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKE 1032
               D    +    ++  +P+P+S  G  +A++L   G    L       D   PDSP   
Sbjct: 3199 FLTDCPDVTVTPADSPVVPDPSSD-GPVVADSLDDDG----LVPVTPADDSVVPDSPANG 3253

Query: 1033 TLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPP-----AACPEVSQARL--LSPARE 1085
             +  +   +G + P     GP   +  A    DAP      A CP+V+      L  +  
Sbjct: 3254 LVVPDPTTDGPVAPDPSVDGPVVPVTPA----DAPTVSVTLADCPDVTVTPPDGLVVSDS 3309

Query: 1086 ERG---LSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQ- 1141
            +RG   ++G ST +P + +  A  + +   P +    V      CPD P    +P     
Sbjct: 3310 KRGGPVVTGLSTNDPVITATPADFSDVTVTP-ADFEDVPVTPANCPDVPVNPESPVVSDL 3368

Query: 1142 --------PEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKG-QPSTPV-DRPLGPDPSA 1191
                      P   L  +E P +VP V        P+ ++ G   S P+ +     DPS 
Sbjct: 3369 AVDFLVVPVVPSDDLVVLEPPDKVPVV--------PDPISNGLVVSDPITNNTAATDPSV 3420

Query: 1192 PGTL--AGAALPPLEPPAPCLCQD----PQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVS 1245
             G++     A  P+ P     C D    P +DSV  +                   A   
Sbjct: 3421 DGSVVPVSPADGPVAPVTLADCPDVTITPADDSVVSD---------------SKIRAEFE 3465

Query: 1246 GTTQPLGTGPRVSLSPHS-PLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGP 1300
                 +   P V ++P S P++S         DLA+   P   +PPP    +P  P
Sbjct: 3466 DVPVTIADCPNVPVNPKSGPVVS---------DLAVD-CPVVPIPPPDDLVAPEPP 3511



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 153/712 (21%), Positives = 241/712 (33%), Gaps = 99/712 (13%)

Query: 579  PVAAAT--IVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTL 636
            PV +A   ++P    +    P  SA  P +P+   D    P   A + +           
Sbjct: 130  PVTSANGPVIPVTPADSPVFPVASADGPVVPVTPADSPVFPVTPADSPLFP-------VT 182

Query: 637  PQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA 696
            P DS   P  P+   + ++ P   A   +V      G  +P   A +P + +  TD    
Sbjct: 183  PADS---PLFPVTPADSAAIPVTPADGPVVHVTPANGTVVPVTPADSPVVTVASTDSPVV 239

Query: 697  PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPL----------QDTDLSSAPKPVAAATLV 746
            P   A   +V     +   +P  SA +P +P+            TD+   P       LV
Sbjct: 240  PVTPADDPIVPVTPADSSFVPVISADSPFVPVIPADGPVVVDSSTDVLVVPVFPVNCILV 299

Query: 747  SQQAEE---------GLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAAT-----IVS 787
               A+E          L +   +A  P +P+   D     ++ A  PV   T      V 
Sbjct: 300  PAFADETIXXXXXXXSLVVSVTTADDPIVPVTPADSPVLSVTLADSPVVPVTPADSPFVP 359

Query: 788  QQAEEGLTLPQDSAMTPPLPLQDTD-----LSSAPKPVAAAT-----LVSQQAEEGLTLP 837
                +G  +P   A +P +P+   D     ++SA  P    T     +VS    +   +P
Sbjct: 360  AIPADGPVVPVTPADSPVVPVTPADGPVVSVASADSPFVPVTPADDPIVSVTPADSPVVP 419

Query: 838  QDSAMTPPLPLQDTD-----LSSAPKPVAAATPVSQ-----QAEEGLTLPQDSAMTAPLP 887
              SA +P +P+   D     +++A  P+   TP         + +G  +P  S   A +P
Sbjct: 420  VTSADSPLIPVTTADGRVVPVTAAGDPIVPVTPADTPGSPVTSADGPVVPVTS---ADIP 476

Query: 888  LQDTGPTSGP-EPLAVA---TPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKN 943
            L    P  GP  P+  A         A+    P T   +        + L     P +  
Sbjct: 477  LVPVTPPDGPVVPVTSADGPVAPVSSADGPVVPVTPADSPFIPVTTADDLIVPVTPADSP 536

Query: 944  AALPTVPEPAALDQVQQDDP-QPAAEAGTPWAAQEDADSTLGMEALSLPE-PASGAGEEI 1001
                T  E  A+     D P  P   A  P      ADS        +P  PA G    +
Sbjct: 537  VLSVTPAESPAIPVTPADSPIVPVTPANGPVVPVTSADSPF------VPVIPADGPVVPV 590

Query: 1002 AEALS-----RPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSA 1056
              A S      P     L         A P +P    +      +G + P+A    P   
Sbjct: 591  TPADSPVVPVTPADSPVLSVTL-ADSPAVPVTPADSPVVPVTPADGPVVPVASADSPFVP 649

Query: 1057 LGGARE-VPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPES 1115
            +  A + +    PA  P +   +  SP      +   S   P +P    T A     P +
Sbjct: 650  VTPADDPIVSVTPAESPAIPVTQADSPV-----VPVTSADRPVIP---VTTADGRIVPVT 701

Query: 1116 SVGAVSSLDRGCPDAPAPT-SAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAK 1174
            + G     D   P  PA T  +P +    PV+ + S + P    +    P++        
Sbjct: 702  AAG-----DPIVPVTPADTPGSPVTSADGPVVPVTSADSPFVPVTPPDGPVVPVTSADGP 756

Query: 1175 GQPSTPVDRPLGPDPSAPGTLA--GAALPPLEPPAPCLCQDPQEDSVEDEEP 1224
              P +  D P+ P  SA G +A   +A  P+ P  P     P       + P
Sbjct: 757  VAPVSSADGPVVPVTSADGPVAPVSSADGPVVPVTPADTNGPAVPVTSADSP 808



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 193/917 (21%), Positives = 306/917 (33%), Gaps = 112/917 (12%)

Query: 438  DGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTA----TVTPHTLQVAPG 493
            DGTV       P   D  A  S    ++S  T +GL +     A     VTP    +AP 
Sbjct: 2994 DGTVVSPTIGGPVVPDPSADSS----VVSNPTTDGLIVPNPLLAGPVVPVTPTDGPLAPV 3049

Query: 494  LQVEVA-TRVTPQAGEEETDSTAGQESAAMAMPQPSQEGI--------SEILGQESVTAE 544
            +  +     VTP  G      T G        P P+ EG+          ++   S    
Sbjct: 3050 ILADCPDVTVTPADGPVVCAFTTG----GPVFPDPTAEGLVVSNPTVDDPVVTNPSTKGL 3105

Query: 545  KLPTPQEETSLTL----CPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDS 600
               TP +   + +    CPD   NL  +  +         A  T+V     +DL  P   
Sbjct: 3106 VSATPADCADVPVIPADCPDVLVNLVNDSVVP-----DFTADWTVVSVSPPDDLVAPDPP 3160

Query: 601  AMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPV 660
               P + +  TD    P       +VS        +P      P + +   +    P P 
Sbjct: 3161 DEVPVVLVPITDGPVVPDLTTDGLVVSVTPAGAPVVPVFLTDCPDVTVTPADSPVVPDPS 3220

Query: 661  AAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDS 720
            +   +V+   +       D  + P  P  D+ +  +P   A   +V     +G   P  S
Sbjct: 3221 SDGPVVADSLD-------DDGLVPVTPADDSVVPDSP---ANGLVVPDPTTDGPVAPDPS 3270

Query: 721  AMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPP---LPLQDTDLSSAP 777
               P +P+   D  +    +A    V+    +GL +       P    L   D  +++ P
Sbjct: 3271 VDGPVVPVTPADAPTVSVTLADCPDVTVTPPDGLVVSDSKRGGPVVTGLSTNDPVITATP 3330

Query: 778  KPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTL- 836
               +  T+     E+   +P   A  P +P+       +   V    +    +++ + L 
Sbjct: 3331 ADFSDVTVTPADFED---VPVTPANCPDVPVNPESPVVSDLAVDFLVVPVVPSDDLVVLE 3387

Query: 837  PQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSA--MTAPLPLQDTGP- 893
            P D     P P+ +  + S   P+   T  +  + +G  +P   A    AP+ L D    
Sbjct: 3388 PPDKVPVVPDPISNGLVVS--DPITNNTAATDPSVDGSVVPVSPADGPVAPVTLADCPDV 3445

Query: 894  TSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPA 953
            T  P   +V +   ++AE    P T  +A      V    GP     +     P VP P 
Sbjct: 3446 TITPADDSVVSDSKIRAEFEDVPVT--IADCPNVPVNPKSGP--VVSDLAVDCPVVPIPP 3501

Query: 954  ALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAG-EEIAEALSRPGREA 1012
              D V    P+P  E   P       DS +  + ++    AS    + I   +  P    
Sbjct: 3502 PDDLVA---PEPPDEV--PVVPDPITDSLVVSDPMTDGPVASDPSIDGIVVPVVSPSGLL 3556

Query: 1013 CLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACP 1072
             L++ A       PD+     +      +G +                  VPD+ P  CP
Sbjct: 3557 VLDSVADVS--ILPDTSADVPVTPVTLADGSV------------------VPDSAPD-CP 3595

Query: 1073 EVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPA 1132
             V           +  + G   P P     V  + + D     S+     +    PD P 
Sbjct: 3596 VVPVLPTDGFVVLDLLVDGVVVPNPADVGPVVPDPTTDG--PDSIKDFPLVPDPWPDCPV 3653

Query: 1133 PTSAPTSQQPEPVLGLGSVEQPHEVPSVLG---TPLLQPPENLAKGQPSTPVDRPLGPDP 1189
                P ++   PV+ L S      VP   G     L+ P +NL    P    D P+ PDP
Sbjct: 3654 ---VPVTRTDGPVV-LDSSADGVVVPVTPGDDSVALVTPTDNLVV--PDLTTDGPVVPDP 3707

Query: 1190 SAPG-----TLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAV 1244
            SA G     +LA   L P  P    +  +   D+    +P     L P     +P+A  +
Sbjct: 3708 SADGPVVLVSLADDLLVPNPPVKDTVVPNSVADNPVALDPVTDCPLVP-----EPSANGL 3762

Query: 1245 SGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPA-GPQGL 1303
               T  L  GP V   P      P V + +   L   ++P      P  P +P  G    
Sbjct: 3763 V-VTDSLDEGPVV---PDPSADDPVVLNPETNGL---VVPDISANGPVVPDTPTDGSDAT 3815

Query: 1304 SAPEQQEDEDSLEEDSP 1320
              P+   +      D P
Sbjct: 3816 VTPDDCSEVFVTATDGP 3832



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 99/432 (22%), Positives = 150/432 (34%), Gaps = 50/432 (11%)

Query: 541  VTAEKLPTPQEETSLTL--CPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQ 598
            V+  K+    E+  +T+  CP+ P N K       P          +VP    +DL  P+
Sbjct: 3455 VSDSKIRAEFEDVPVTIADCPNVPVNPKSG-----PVVSDLAVDCPVVPIPPPDDLVAPE 3509

Query: 599  DSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLP---------QDSVMTPPLPLQ 649
                 P +P   TD      P+    + S  + +G+ +P          DSV    + L 
Sbjct: 3510 PPDEVPVVPDPITDSLVVSDPMTDGPVASDPSIDGIVVPVVSPSGLLVLDSVADVSI-LP 3568

Query: 650  DTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQ 709
            DT   SA  PV   TL      +G  +P  +   P +P+  TD       +    +V   
Sbjct: 3569 DT---SADVPVTPVTLA-----DGSVVPDSAPDCPVVPVLPTDGFVVLDLLVDGVVVPNP 3620

Query: 710  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ 769
            A+ G  +P D     P  ++D  L   P P     +V     +G  +   SA    +P+ 
Sbjct: 3621 ADVGPVVP-DPTTDGPDSIKDFPL--VPDPWPDCPVVPVTRTDGPVVLDSSADGVVVPVT 3677

Query: 770  DTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQ 829
              D S A        +V     +G  +P  SA  P + +   D    P P    T+V   
Sbjct: 3678 PGDDSVALVTPTDNLVVPDLTTDGPVVPDPSADGPVVLVSLADDLLVPNPPVKDTVV--- 3734

Query: 830  AEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQ 889
                   P   A  P      TD    P+P A    V+   +EG  +P  SA        
Sbjct: 3735 -------PNSVADNPVALDPVTDCPLVPEPSANGLVVTDSLDEGPVVPDPSA-------- 3779

Query: 890  DTGPTSGPEPLAVATPQTLQAEAGCAPGTE---PVATMAQQEVGEALGPRPAPEEKNAAL 946
            D      PE   +  P  + A     P T      AT+   +  E         +  +  
Sbjct: 3780 DDPVVLNPETNGLVVPD-ISANGPVVPDTPTDGSDATVTPDDCSEVFVTATDGPDVVSDC 3838

Query: 947  PTVPEPAALDQV 958
            P VPE +  D +
Sbjct: 3839 PIVPETSDDDLI 3850



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 85/411 (20%), Positives = 143/411 (34%), Gaps = 53/411 (12%)

Query: 483  VTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVT 542
            V P T++ + G +V V     P  G   TDS A     ++    P  +G+  +   + V 
Sbjct: 2774 VVPDTVRDSDGPEVSVY----PVTGPVVTDSAADCPVVSV----PLTDGLVVLCPPDEVP 2825

Query: 543  AEK--------LPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDL 594
            A          +P P  +  +   P     +      D P    P+ A  +VP+ +    
Sbjct: 2826 AVHDSVTNGLVVPDPVIDGPVFSNPSVDGPIVPVASADNPGVPDPIRAFPVVPKPSTFSP 2885

Query: 595  TLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS-----VMTPPLPLQ 649
             +    A    + +   D +  P       +V   + +   +P        V+ PP    
Sbjct: 2886 VVTSTPADWIDVIVTPADCADVPVNPVNGPVVPDLSGDCPVVPVPPTDDIVVLNPP---- 2941

Query: 650  DTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQ-----DTDLSSA-------- 696
            D   +    PV    +V+  A +GL +P   A     P+      D  ++ A        
Sbjct: 2942 DVVFAVVSTPVTDGPVVTDPATDGLMVPVTPANGSVAPVTLSEYPDVTVTPADGTVVSPT 3001

Query: 697  ------PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQA 750
                  P P A +++VS    +GL +P      P +P+  TD   AP  +A    V+   
Sbjct: 3002 IGGPVVPDPSADSSVVSNPTTDGLIVPNPLLAGPVVPVTPTDGPLAPVILADCPDVTVTP 3061

Query: 751  EEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGL--TLPQDSAMTPPLPL 808
             +G  +   +   P  P    +      P     +V+  + +GL    P D A  P +P 
Sbjct: 3062 ADGPVVCAFTTGGPVFPDPTAEGLVVSNPTVDDPVVTNPSTKGLVSATPADCADVPVIPA 3121

Query: 809  QDTDL-------SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTD 852
               D+       S  P   A  T+VS    + L  P      P + +  TD
Sbjct: 3122 DCPDVLVNLVNDSVVPDFTADWTVVSVSPPDDLVAPDPPDEVPVVLVPITD 3172


>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
            [Homo sapiens]
          Length = 1412

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 187/925 (20%), Positives = 326/925 (35%), Gaps = 127/925 (13%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  GLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 629
              +     K       +P  A         S  +P           + +P A  T+VS+ 
Sbjct: 126  KAETEKAGK---TGNSMPHPATGKTVANLLSGKSP---------RKSAEPSANTTLVSET 173

Query: 630  AEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAAT----LVSQQAEEGLTLPQDSAMTPP 685
             EEG ++P       P  +   +  S+ +  ++++    +  + +E+ L +   SA    
Sbjct: 174  EEEG-SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKG 232

Query: 686  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL 745
             P +     + P P   A  V+ Q + G   P++ + +        + S + +   AA  
Sbjct: 233  TPGK----GATPAPPGKAGAVASQTKAGK--PEEDSES-----SSEESSDSEEETPAAKA 281

Query: 746  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATIVSQQAEEGLTLPQDSA 801
            + Q    G T    +A  P         + AP     P  A     ++ E+  +  ++S 
Sbjct: 282  LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 341

Query: 802  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 861
                 P Q      AP+  AA+    +   +G           P P + T       P A
Sbjct: 342  SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA---------PAPPRKTG------PAA 386

Query: 862  AATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPV 921
            A   V +Q E+  +  ++S              S  E LA      ++   G +P  +P 
Sbjct: 387  AQVQVGKQEEDSRSSSEES-------------DSDREALAAMNAAQVKP-LGKSPQVKPA 432

Query: 922  ATMAQQEVGEALGPRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDA 979
            +TM    +G+  GP P P +   A P+  V +     +   ++   +++   P A     
Sbjct: 433  STMGMGPLGKGAGPVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 491

Query: 980  DSTLG--MEALSLPEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETL 1034
            + +LG  ++A     PA G  ++      +   E  +   E+   + D A  DS +    
Sbjct: 492  EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAA 549

Query: 1035 EVENQQEGGLKPLAQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGK 1092
                Q +  LK    +  P+  +    A+  P       P  +     SPA     ++G 
Sbjct: 550  MTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG- 607

Query: 1093 STPEPTLPSAVATEASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPV 1145
             T  P   S+ + E+  DS  E +     VG   S+ +G     A  P      Q   PV
Sbjct: 608  GTQRPAEDSSSSEES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 665

Query: 1146 L-----------------GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPL 1185
            L                    S E+  +      +P        +  AK  P+       
Sbjct: 666  LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 725

Query: 1186 GPDPSAPGTLAGAALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQ 1238
                SAPG +  AA          ++PP     ++PQ  +V    P     +P     V 
Sbjct: 726  KGTISAPGKVVTAAAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVA 778

Query: 1239 PAAAAVSGTTQPLGTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSP 1297
             AA A +G  +  G+    S S   +  L+    S     +   + P  + P      +P
Sbjct: 779  TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 838

Query: 1298 AGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAP 1357
             G  G SA +  + +DS          S + SDS GE+ A +    ++ P  +       
Sbjct: 839  PGKTGPSAAQAGKQDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRS 890

Query: 1358 AGGSEETIAKAKQSRSEKKARKAMS 1382
              G   T A+A+ + + +KAR + S
Sbjct: 891  PAGPAATPAQAQAASTPRKARASES 915



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 158/768 (20%), Positives = 261/768 (33%), Gaps = 76/768 (9%)

Query: 328  PLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDL----SITEGMDEAFAFRDD 383
            P       EE+ ++ +  G     G+  S         + +    S+ +G       +  
Sbjct: 612  PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 671

Query: 384  TSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS- 442
             +     ++    +E+ +E   S E  A    ++ SV+KT+ ++   A    +  GT+S 
Sbjct: 672  PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 731

Query: 443  --WAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT 500
                V AA Q   R      +  + +      LA G  S  +V      VA   Q +   
Sbjct: 732  PGKVVTAAAQAKQRSP-SKVKPPVRNPQNSTVLARGPASVPSVGK---AVATAAQAQTGP 787

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEIL--GQESVTAEKLPTPQEETSLTLC 558
                 + EEE+DS    E+ A   P      I   L   +ES      PTP  +T  +  
Sbjct: 788  EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847

Query: 559  ----PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLS 614
                 D   +  EE   D  +     +A  I P     D   P  S   P         +
Sbjct: 848  QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD---PNRSPAGPAATPAQAQAA 904

Query: 615  SAPKPVAA----ATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSA-PK--PVAAATLVS 667
            S P+   A    A   S ++E+   +P    +TP +      + +A P+  P A+    S
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 964

Query: 668  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 727
               E            P   +   + +S P   AA  +++Q+A E        A T P  
Sbjct: 965  SSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEA---QPPVARTQPSS 1021

Query: 728  LQDTDLSSAPKPVAAATLVSQQAEEGLTLP-----QDSAMTPPLPLQDTDLSSAPKPVAA 782
              D+ + + P     +T V  +    L  P     Q +   P       D S +      
Sbjct: 1022 GVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEE 1081

Query: 783  ATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA--ATLVSQQAEEGLTLPQDS 840
                 Q A+   TL   +       +++T   S+   V A   +L+S     GLT P +S
Sbjct: 1082 DGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLT-PANS 1140

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSA-MTAPLPLQDTGPTSGPEP 899
              +   P  D+  S +    A   P  +Q  +    PQ +A M +P        T G E 
Sbjct: 1141 QASKATPKLDSSPSVSSTLAAKDDPDGKQEAK----PQQAAGMLSP-------KTGGKEA 1189

Query: 900  LAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAP-------------------E 940
             +  TPQ  +     A   +      Q  + + L  +P P                   +
Sbjct: 1190 ASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQ 1249

Query: 941  EKNAALPTVPEPAALD----QVQQDDPQPAAEAGTPWA-AQEDADSTLGMEALSLPEPAS 995
            E+   + T  E +       + +    QPAA   TP +  ++   +  G EA   PE  S
Sbjct: 1250 ERKKVVDTTKESSRKGWESRKRKLSGDQPAAR--TPRSKKKKKLGAGEGGEASVSPEKTS 1307

Query: 996  GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGG 1043
               +  A+     G     + +   G     D P++E  +     EGG
Sbjct: 1308 TTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGG 1355



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 165/765 (21%), Positives = 271/765 (35%), Gaps = 134/765 (17%)

Query: 769  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATLVS 827
            +D  L +    V+     S+ +EE      ++A  TP L   ++ +  A  P +      
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 828  QQAEE----GLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 882
             + E+    G ++P  +   T    L       + +P A  T VS+  EEG ++P   A 
Sbjct: 127  AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG-SVPAFGAA 185

Query: 883  TAPLPL---------QDTGPTSGPEPLAV-ATPQTLQAEAGCAPGTEPVATMAQQEVGEA 932
              P  +         +DT  +S    + V A+ + LQ  A  AP        A+   G+ 
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP--------AKGTPGK- 236

Query: 933  LGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPE 992
             G  PAP  K  A+ +        Q +   P+  +E+ +  ++  + + T   +AL L  
Sbjct: 237  -GATPAPPGKAGAVAS--------QTKAGKPEEDSESSSEESSDSE-EETPAAKAL-LQA 285

Query: 993  PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHG 1052
             ASG   ++  A S P +E+  +       GA P  P K    V   Q G  +  +Q   
Sbjct: 286  KASGKTSQVGAA-SAPAKESPRK-------GAAPAPPGKTGPAVAKAQAGKREEDSQSSS 337

Query: 1053 PRSALGGAREVPDAPPAACPEVSQARLLSPAREE-RGLSGKSTPEPTLPSAVATEASLDS 1111
              S           P    P+V  A   +PA+E  R  +  + P  T P+A   +     
Sbjct: 338  EESDSEEEAPAQAKPSGKAPQVRAAS--APAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 395

Query: 1112 CPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPEN 1171
                S    S  DR         +A  + Q +P   LG             +P ++P   
Sbjct: 396  EDSRSSSEESDSDREA------LAAMNAAQVKP---LGK------------SPQVKPAST 434

Query: 1172 LAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLP 1231
            +  G    P+ +  GP P  PG +      P  P A     +   +S  +E    S G  
Sbjct: 435  MGMG----PLGKGAGPVP--PGKVG-----PATPSAQVGKWEEDSESSSEESSDSSDGEV 483

Query: 1232 PPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPP 1291
            P    V PA     G                  +L  K  S  AK               
Sbjct: 484  P--TAVAPAQEKSLGN-----------------ILQAKPTSSPAK--------------- 509

Query: 1292 SGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQ 1351
             GP   AGP  +    ++  ++S  E S  +  S    ++    +A   +  +  PQT  
Sbjct: 510  -GPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566

Query: 1352 CPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLR-QIQGVTRITIQKSKNILFVIAKP 1410
            CP +     S +       +++ +KA  A S  G    + G T+   + S +     ++ 
Sbjct: 567  CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS-----SEE 621

Query: 1411 DVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFK----------VPSEPSALVPESAPR 1460
               +   +   V  G+AK      QV KAA+   K          +P +    V +    
Sbjct: 622  SDSEEEKTGLAVTVGQAKSVGKGLQV-KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE 680

Query: 1461 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRA 1505
             +   E  EEE + EE           ++   A+AN + A+A  A
Sbjct: 681  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 725



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 208/1044 (19%), Positives = 352/1044 (33%), Gaps = 181/1044 (17%)

Query: 270  TPEPPSSESSLSADSSSSWGQEGHFFDLDFLAN-DPMIPAALLPFQGSLIFQVEAVEVTP 328
            TP PP    ++++ + +   +E      +  ++ +   PAA    Q     +   V    
Sbjct: 239  TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAAS 298

Query: 329  LSPEEEEEEAVADPDPGGD-------LAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFR 381
               +E   +  A   PG          AG+ EEDS S+S      + +  +      A +
Sbjct: 299  APAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQ 358

Query: 382  -DDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGT 440
                SA + +S     A A   +        Q    ++  + + EES    + L A +  
Sbjct: 359  VRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAA 418

Query: 441  VSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT 500
                +  +PQ                 +   G   G      V P T    P  QV    
Sbjct: 419  QVKPLGKSPQVKPASTM---------GMGPLGKGAGPVPPGKVGPAT----PSAQVGKWE 465

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEE--TSLTLC 558
              +  + EE +DS+ G+   A+A  Q  ++ +  IL  +  ++     PQ+    ++ + 
Sbjct: 466  EDSESSSEESSDSSDGEVPTAVAPAQ--EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 523

Query: 559  PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPK 618
             + P +  E       S     A A +   QA+  L +PQ  A       + T+ +++ K
Sbjct: 524  AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP-----KKTNTTASAK 578

Query: 619  PVAAATIVSQQAEEGLTLPQDSVMTPPL------PLQDTELSSAPKPVAAATLVSQQAEE 672
             VA   + +Q   +  T    +  +P +      P +D+  S            S++ + 
Sbjct: 579  -VAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESD--------SEEEKT 629

Query: 673  GLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTD 732
            GL +    A +    LQ   + +A  PV  +            L Q +A  P LP     
Sbjct: 630  GLAVTVGQAKSVGKGLQ---VKAASVPVKGS------------LGQGTA--PVLP----- 667

Query: 733  LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEE 792
                   V       Q+  E      DS      P Q    +S  K  A A   + +A  
Sbjct: 668  -GKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK--TSVKKTQAKANPAAARA-- 722

Query: 793  GLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL--PLQD 850
                          P     +S+  K V AA    Q++         S + PP+  P   
Sbjct: 723  --------------PSAKGTISAPGKVVTAAAQAKQRSP--------SKVKPPVRNPQNS 760

Query: 851  TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATP--QTL 908
            T L+  P  V +       A +  T P++ + ++    +++      E LA   P  +T 
Sbjct: 761  TVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE---EESDSEEEAETLAQVKPSGKTH 817

Query: 909  QAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAE 968
            Q  A  AP  E              G  P P  K         P+A    +QDD   ++E
Sbjct: 818  QIRAALAPAKE----------SPRKGAAPTPPGKTG-------PSAAQAGKQDDSGSSSE 860

Query: 969  AGTPWAAQEDADSTLGMEALSLPEPA--------SGAGEEI----AEALSRPGREACLEA 1016
                  +  D ++   + +  + +P         S AG       A+A S P +    E+
Sbjct: 861  E-----SDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 915

Query: 1017 RAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQ 1076
             A +      +S  ++ +        G++                 +P A P   P+ S 
Sbjct: 916  TARSSSS---ESEDEDVIPATQCLTPGIRT------------NVVTMPTAHPRIAPKASM 960

Query: 1077 ARLLSPAREERGLSGKSTPEP----------TLP------SAVATEASLDSCPESSVGAV 1120
            A   S     R   GK    P          +LP        +A +AS    P +     
Sbjct: 961  AGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPS 1020

Query: 1121 SSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTP 1180
            S +D      PA +   TS Q +   G   + +P ++P V      + PE+    + S+ 
Sbjct: 1021 SGVDSAVGTLPATSPQSTSVQAK---GTNKLRKP-KLPEV--QQATKAPESSDDSEDSS- 1073

Query: 1181 VDRPLGPDPSAPGTLAGAALPPLEPPAP----CLCQDPQEDSVEDE--EPPGSLGLPPPQ 1234
             D   G +    G     +   L  P P     L ++   +S ED+   P  SL      
Sbjct: 1074 -DSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMT 1132

Query: 1235 AGVQPAAAAVSGTTQPLGTGPRVS 1258
             G+ PA +  S  T  L + P VS
Sbjct: 1133 PGLTPANSQASKATPKLDSSPSVS 1156


>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
            sapiens]
          Length = 1411

 Score = 78.6 bits (192), Expect = 4e-14
 Identities = 187/925 (20%), Positives = 326/925 (35%), Gaps = 127/925 (13%)

Query: 510  ETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEG 569
            E D+    +   ++ P  + E   E    E+ TA+  P      S  L  D P ++KE+ 
Sbjct: 66   EEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKA 125

Query: 570  GLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ 629
              +     K       +P  A         S  +P           + +P A  T+VS+ 
Sbjct: 126  KAETEKAGK---TGNSMPHPATGKTVANLLSGKSP---------RKSAEPSANTTLVSET 173

Query: 630  AEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAAT----LVSQQAEEGLTLPQDSAMTPP 685
             EEG ++P       P  +   +  S+ +  ++++    +  + +E+ L +   SA    
Sbjct: 174  EEEG-SVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKG 232

Query: 686  LPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATL 745
             P +     + P P   A  V+ Q + G   P++ + +        + S + +   AA  
Sbjct: 233  TPGK----GATPAPPGKAGAVASQTKAGK--PEEDSES-----SSEESSDSEEETPAAKA 281

Query: 746  VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK----PVAAATIVSQQAEEGLTLPQDSA 801
            + Q    G T    +A  P         + AP     P  A     ++ E+  +  ++S 
Sbjct: 282  LLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESD 341

Query: 802  MTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 861
                 P Q      AP+  AA+    +   +G           P P + T       P A
Sbjct: 342  SEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAA---------PAPPRKTG------PAA 386

Query: 862  AATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPV 921
            A   V +Q E+  +  ++S              S  E LA      ++   G +P  +P 
Sbjct: 387  AQVQVGKQEEDSRSSSEES-------------DSDREALAAMNAAQVKP-LGKSPQVKPA 432

Query: 922  ATMAQQEVGEALGPRPAPEEKNAALPT--VPEPAALDQVQQDDPQPAAEAGTPWAAQEDA 979
            +TM    +G+  GP P P +   A P+  V +     +   ++   +++   P A     
Sbjct: 433  STMGMGPLGKGAGPVP-PGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQ 491

Query: 980  DSTLG--MEALSLPEPASGAGEEIAEALSRPGREACL---EARAHTGDGAKPDSPQKETL 1034
            + +LG  ++A     PA G  ++      +   E  +   E+   + D A  DS +    
Sbjct: 492  EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSA--DSEEAPAA 549

Query: 1035 EVENQQEGGLKPLAQEHGPR--SALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGK 1092
                Q +  LK    +  P+  +    A+  P       P  +     SPA     ++G 
Sbjct: 550  MTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKA-GTATSPAGSSPAVAG- 607

Query: 1093 STPEPTLPSAVATEASLDSCPESS-----VGAVSSLDRGCP--DAPAPTSAPTSQQPEPV 1145
             T  P   S+ + E+  DS  E +     VG   S+ +G     A  P      Q   PV
Sbjct: 608  GTQRPAEDSSSSEES--DSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 665

Query: 1146 L-----------------GLGSVEQPHEVPSVLGTPL---LQPPENLAKGQPSTPVDRPL 1185
            L                    S E+  +      +P        +  AK  P+       
Sbjct: 666  LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 725

Query: 1186 GPDPSAPGTLAGAALPP-------LEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQ 1238
                SAPG +  AA          ++PP     ++PQ  +V    P     +P     V 
Sbjct: 726  KGTISAPGKVVTAAAQAKQRSPSKVKPPV----RNPQNSTVLARGPAS---VPSVGKAVA 778

Query: 1239 PAAAAVSGTTQPLGTGPRVSLSPH-SPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSP 1297
             AA A +G  +  G+    S S   +  L+    S     +   + P  + P      +P
Sbjct: 779  TAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTP 838

Query: 1298 AGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAP 1357
             G  G SA +  + +DS          S + SDS GE+ A +    ++ P  +       
Sbjct: 839  PGKTGPSAAQAGKQDDSGS--------SSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRS 890

Query: 1358 AGGSEETIAKAKQSRSEKKARKAMS 1382
              G   T A+A+ + + +KAR + S
Sbjct: 891  PAGPAATPAQAQAASTPRKARASES 915



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 160/768 (20%), Positives = 263/768 (34%), Gaps = 77/768 (10%)

Query: 328  PLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDL----SITEGMDEAFAFRDD 383
            P       EE+ ++ +  G     G+  S         + +    S+ +G       +  
Sbjct: 612  PAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTG 671

Query: 384  TSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVS- 442
             +     ++    +E+ +E   S E  A    ++ SV+KT+ ++   A    +  GT+S 
Sbjct: 672  PTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 731

Query: 443  --WAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT 500
                V AA Q   R      +  + +      LA G  S  +V      VA   Q +   
Sbjct: 732  PGKVVTAAAQAKQRSP-SKVKPPVRNPQNSTVLARGPASVPSVGK---AVATAAQAQTGP 787

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEIL--GQESVTAEKLPTPQEETSLTLC 558
                 + EEE+DS    E+ A   P      I   L   +ES      PTP  +T  +  
Sbjct: 788  EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847

Query: 559  ----PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLS 614
                 D   +  EE   D  +     +A  I P     D   P  S   P         +
Sbjct: 848  QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD---PNRSPAGPAATPAQAQAA 904

Query: 615  SAPKPVAA----ATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSA-PK--PVAAATLVS 667
            S P+   A    A   S ++E+   +P    +TP +      + +A P+  P A+    S
Sbjct: 905  STPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGAS 964

Query: 668  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 727
               E            P   +   + +S P   AA  +++Q+A E        A T P  
Sbjct: 965  SSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEA---QPPVARTQPSS 1021

Query: 728  LQDTDLSSAPKPVAAATLVSQQAEEGLTLP-----QDSAMTPPLPLQDTDLSSAPKPVAA 782
              D+ + + P     +T V  +    L  P     Q +   P       D S +      
Sbjct: 1022 GVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEE 1081

Query: 783  ATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAA--ATLVSQQAEEGLTLPQDS 840
                 Q A+   TL    + T  L +++T   S+   V A   +L+S     GLT P +S
Sbjct: 1082 DGEGPQGAKSAHTLGPTPSRTETL-VEETAAESSEDDVVAPSQSLLSGYMTPGLT-PANS 1139

Query: 841  AMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSA-MTAPLPLQDTGPTSGPEP 899
              +   P  D+  S +    A   P  +Q  +    PQ +A M +P        T G E 
Sbjct: 1140 QASKATPKLDSSPSVSSTLAAKDDPDGKQEAK----PQQAAGMLSP-------KTGGKEA 1188

Query: 900  LAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAP-------------------E 940
             +  TPQ  +     A   +      Q  + + L  +P P                   +
Sbjct: 1189 ASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQ 1248

Query: 941  EKNAALPTVPEPAALD----QVQQDDPQPAAEAGTPWA-AQEDADSTLGMEALSLPEPAS 995
            E+   + T  E +       + +    QPAA   TP +  ++   +  G EA   PE  S
Sbjct: 1249 ERKKVVDTTKESSRKGWESRKRKLSGDQPAAR--TPRSKKKKKLGAGEGGEASVSPEKTS 1306

Query: 996  GAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGG 1043
               +  A+     G     + +   G     D P++E  +     EGG
Sbjct: 1307 TTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGG 1354



 Score = 59.3 bits (142), Expect = 3e-08
 Identities = 165/765 (21%), Positives = 271/765 (35%), Gaps = 134/765 (17%)

Query: 769  QDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAM-TPPLPLQDTDLSSAPKPVAAATLVS 827
            +D  L +    V+     S+ +EE      ++A  TP L   ++ +  A  P +      
Sbjct: 67   EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKEKAK 126

Query: 828  QQAEE----GLTLPQDSA-MTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAM 882
             + E+    G ++P  +   T    L       + +P A  T VS+  EEG ++P   A 
Sbjct: 127  AETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEG-SVPAFGAA 185

Query: 883  TAPLPL---------QDTGPTSGPEPLAV-ATPQTLQAEAGCAPGTEPVATMAQQEVGEA 932
              P  +         +DT  +S    + V A+ + LQ  A  AP        A+   G+ 
Sbjct: 186  AKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAP--------AKGTPGK- 236

Query: 933  LGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPE 992
             G  PAP  K  A+ +        Q +   P+  +E+ +  ++  + + T   +AL L  
Sbjct: 237  -GATPAPPGKAGAVAS--------QTKAGKPEEDSESSSEESSDSE-EETPAAKAL-LQA 285

Query: 993  PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHG 1052
             ASG   ++  A S P +E+  +       GA P  P K    V   Q G  +  +Q   
Sbjct: 286  KASGKTSQVGAA-SAPAKESPRK-------GAAPAPPGKTGPAVAKAQAGKREEDSQSSS 337

Query: 1053 PRSALGGAREVPDAPPAACPEVSQARLLSPAREE-RGLSGKSTPEPTLPSAVATEASLDS 1111
              S           P    P+V  A   +PA+E  R  +  + P  T P+A   +     
Sbjct: 338  EESDSEEEAPAQAKPSGKAPQVRAAS--APAKESPRKGAAPAPPRKTGPAAAQVQVGKQE 395

Query: 1112 CPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPEN 1171
                S    S  DR         +A  + Q +P   LG             +P ++P   
Sbjct: 396  EDSRSSSEESDSDREA------LAAMNAAQVKP---LGK------------SPQVKPAST 434

Query: 1172 LAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLP 1231
            +  G    P+ +  GP P  PG +      P  P A     +   +S  +E    S G  
Sbjct: 435  MGMG----PLGKGAGPVP--PGKVG-----PATPSAQVGKWEEDSESSSEESSDSSDGEV 483

Query: 1232 PPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPP 1291
            P    V PA     G                  +L  K  S  AK               
Sbjct: 484  P--TAVAPAQEKSLGN-----------------ILQAKPTSSPAK--------------- 509

Query: 1292 SGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQ 1351
             GP   AGP  +    ++  ++S  E S  +  S    ++    +A   +  +  PQT  
Sbjct: 510  -GPPQKAGPVAVQVKAEKPMDNS--ESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKA 566

Query: 1352 CPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLR-QIQGVTRITIQKSKNILFVIAKP 1410
            CP +     S +       +++ +KA  A S  G    + G T+   + S +     ++ 
Sbjct: 567  CPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSS-----SEE 621

Query: 1411 DVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFK----------VPSEPSALVPESAPR 1460
               +   +   V  G+AK      QV KAA+   K          +P +    V +    
Sbjct: 622  SDSEEEKTGLAVTVGQAKSVGKGLQV-KAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAE 680

Query: 1461 PRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRA 1505
             +   E  EEE + EE           ++   A+AN + A+A  A
Sbjct: 681  KQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSA 725



 Score = 56.6 bits (135), Expect = 2e-07
 Identities = 207/1041 (19%), Positives = 350/1041 (33%), Gaps = 176/1041 (16%)

Query: 270  TPEPPSSESSLSADSSSSWGQEGHFFDLDFLAN-DPMIPAALLPFQGSLIFQVEAVEVTP 328
            TP PP    ++++ + +   +E      +  ++ +   PAA    Q     +   V    
Sbjct: 239  TPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAAS 298

Query: 329  LSPEEEEEEAVADPDPGGD-------LAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFR 381
               +E   +  A   PG          AG+ EEDS S+S      + +  +      A +
Sbjct: 299  APAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQ 358

Query: 382  -DDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGT 440
                SA + +S     A A   +        Q    ++  + + EES    + L A +  
Sbjct: 359  VRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAA 418

Query: 441  VSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVAT 500
                +  +PQ                 +   G   G      V P T    P  QV    
Sbjct: 419  QVKPLGKSPQVKPASTM---------GMGPLGKGAGPVPPGKVGPAT----PSAQVGKWE 465

Query: 501  RVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEE--TSLTLC 558
              +  + EE +DS+ G+   A+A  Q  ++ +  IL  +  ++     PQ+    ++ + 
Sbjct: 466  EDSESSSEESSDSSDGEVPTAVAPAQ--EKSLGNILQAKPTSSPAKGPPQKAGPVAVQVK 523

Query: 559  PDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPK 618
             + P +  E       S     A A +   QA+  L +PQ  A       + T+ +++ K
Sbjct: 524  AEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACP-----KKTNTTASAK 578

Query: 619  PVAAATIVSQQAEEGLTLPQDSVMTPPL------PLQDTELSSAPKPVAAATLVSQQAEE 672
             VA   + +Q   +  T    +  +P +      P +D+  S            S++ + 
Sbjct: 579  -VAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESD--------SEEEKT 629

Query: 673  GLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTD 732
            GL +    A +    LQ   + +A  PV  +            L Q +A  P LP     
Sbjct: 630  GLAVTVGQAKSVGKGLQ---VKAASVPVKGS------------LGQGTA--PVLP----- 667

Query: 733  LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEE 792
                   V       Q+  E      DS      P Q    +S  K  A A   + +A  
Sbjct: 668  -GKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVK--TSVKKTQAKANPAAARA-- 722

Query: 793  GLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPL--PLQD 850
                          P     +S+  K V AA    Q++         S + PP+  P   
Sbjct: 723  --------------PSAKGTISAPGKVVTAAAQAKQRSP--------SKVKPPVRNPQNS 760

Query: 851  TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATP--QTL 908
            T L+  P  V +       A +  T P++ + ++    +++      E LA   P  +T 
Sbjct: 761  TVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSE---EESDSEEEAETLAQVKPSGKTH 817

Query: 909  QAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAE 968
            Q  A  AP  E              G  P P  K         P+A    +QDD   ++E
Sbjct: 818  QIRAALAPAKE----------SPRKGAAPTPPGKTG-------PSAAQAGKQDDSGSSSE 860

Query: 969  AGTPWAAQEDADSTLGMEALSLPEPA--------SGAGEEI----AEALSRPGREACLEA 1016
                  +  D ++   + +  + +P         S AG       A+A S P +    E+
Sbjct: 861  E-----SDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASES 915

Query: 1017 RAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQ 1076
             A +      +S  ++ +        G++                 +P A P   P+ S 
Sbjct: 916  TARSSSS---ESEDEDVIPATQCLTPGIRT------------NVVTMPTAHPRIAPKASM 960

Query: 1077 ARLLSPAREERGLSGKSTPEP----------TLP------SAVATEASLDSCPESSVGAV 1120
            A   S     R   GK    P          +LP        +A +AS    P +     
Sbjct: 961  AGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPS 1020

Query: 1121 SSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTP 1180
            S +D      PA +   TS Q +   G   + +P ++P V      + PE+    + S+ 
Sbjct: 1021 SGVDSAVGTLPATSPQSTSVQAK---GTNKLRKP-KLPEV--QQATKAPESSDDSEDSSD 1074

Query: 1181 VDRPLGPDPSAP-GTLAGAALPPLEPPAPCLCQDPQEDSVEDE--EPPGSLGLPPPQAGV 1237
                   D   P G  +   L P       L ++   +S ED+   P  SL       G+
Sbjct: 1075 SSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGL 1134

Query: 1238 QPAAAAVSGTTQPLGTGPRVS 1258
             PA +  S  T  L + P VS
Sbjct: 1135 TPANSQASKATPKLDSSPSVS 1155


>gi|167736355 mucin 4 isoform a [Homo sapiens]
          Length = 5284

 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 309/1430 (21%), Positives = 464/1430 (32%), Gaps = 205/1430 (14%)

Query: 66   QPEGASWDAGPGGAPSAWADPGEGGPSPM----LLPEGLSSQALSTEAPLPATLEPRIVM 121
            +  G +  + P  + S     G   PS        P G    + S E    ++   R   
Sbjct: 780  EASGQTQTSEPASSGSRTTSAGTATPSSSGASGTTPSGSEGISTSGETTRFSSNPSRDSH 839

Query: 122  GEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTPT 181
              ++   LLS  A+  A+    G  +S  P     +  + S    P    S  +P ++P 
Sbjct: 840  TTQSTTELLSASASHGAIPVSTGMASSIVPGTFHPTLSEASTAGRPTGQSSPTSPSASPQ 899

Query: 182  KTTYALLPA------CGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCS 235
            +T      A           D     ++  D     PP  PS   IT+ G    +SP   
Sbjct: 900  ETAAISRMAQTQRTRTSRGSDTISLASQATDTFSTVPPTPPS---ITSTG---LTSPQTE 953

Query: 236  LSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFF 295
               L+P       SG G +   +++         TP P +  SS S   ++      H  
Sbjct: 954  THTLSP-------SGSGKTFTTALISN------ATPLPVTYASSASTGHTTPL----HVT 996

Query: 296  DLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEED 355
            D   ++     P   LP               P++    E      P P    +     D
Sbjct: 997  DASSVSTGHATP---LPVTSPSSVSTGHTTPLPVTDTSSESTGHVTPLPVTSFSSASTGD 1053

Query: 356  ST-------SASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGE 408
            ST       S++    ++ L +T     +    D T    +D+ SAS   A    +    
Sbjct: 1054 STPLPVTDTSSASTGHVTPLPVTSLSSASTG--DTTPLPVTDTSSASTGHATSLPVTDTS 1111

Query: 409  PHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEV 468
              +        V  T   S G A  L   D +        P      +  S  Q     V
Sbjct: 1112 SVSTGHTTPLPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLHVTDASSASTGQATPLPV 1171

Query: 469  TEEGLALGQESTATVTP---------HTLQVAPGLQVEVATRVTPQAG-----EEETDST 514
            T    +L   ST   TP          T    P L  + ++  T  A      +  + ST
Sbjct: 1172 T----SLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPLPVTDASSVST 1227

Query: 515  AGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLP 574
                S  + +P  +  G +  L    VT     +  + TSL +   S  +  +   L + 
Sbjct: 1228 DHATSLPVTIPSAASTGHTTPL---PVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPVT 1284

Query: 575  SGRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSA------PKPVAAATIVSQ 628
            S     +   + P      +T P  ++     PL  T LSSA      P PV + +  S 
Sbjct: 1285 S-TSSASTGHVTPLH----VTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSAST 1339

Query: 629  QAEEGLTLPQDSVMTP--PLPLQDTELSSA------PKPVAAATLVSQQAEEGL--TLPQ 678
                 L +   S ++     PL  T+ SSA      P PV + + VS      L  T P 
Sbjct: 1340 GDTTPLPVTDASSVSTGHTTPLHVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPS 1399

Query: 679  DSAMTPPLPLQDTDLSSA------PKPVAAATLVSQQAEEGL--TLPQDSAMTPPLPLQD 730
             ++     PL  TD SSA      P PV  A+ VS      L  T+P  ++     PL  
Sbjct: 1400 SASTGHATPLLVTDTSSASTGHATPLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLPV 1459

Query: 731  TDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK--PVAAATIVSQ 788
            TD SSA    A + LV+       T    +  T PLP+  T  +S     P+   +  S 
Sbjct: 1460 TDTSSASTGQATSLLVTD------TSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSA 1513

Query: 789  QAEEGLTLPQDSAM------TPPLPLQDTDLSSA----PKPVAAATLVSQQAEEGL--TL 836
                   LP  S        T PLP+     +S     P PV  A+ VS      L  T 
Sbjct: 1514 STGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLPVTS 1573

Query: 837  PQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDT--GPT 894
            P  ++     PL  TD SSA K      PV+  +         +  T PLP+ DT    T
Sbjct: 1574 PSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSS------ASTGHTTPLPVTDTSSAST 1627

Query: 895  SGPEPLAV----------ATPQTLQAEAGCAPGTE---PVATMAQQEVGEA-----LGPR 936
                PL V          ATP  + + +  + G     PV + +    G A      G  
Sbjct: 1628 GDTTPLPVTNASSLSTGHATPLHVTSPSSASTGHATPLPVTSTSSASTGHATPLPVTGLS 1687

Query: 937  PAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAG-------TPWAAQEDADSTLGMEALS 989
             A  +    LP     +A     Q  P P            TP      + ++ G  +  
Sbjct: 1688 SATTDDTTRLPVTDVSSA--STGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHASPL 1745

Query: 990  LPEPASGAGEEIAEALSRPGREACLEARAHT--------GDGAKPDSPQKETLEVENQQE 1041
            L   AS A     +A   P  +    + AH            +  D+ +    +V +   
Sbjct: 1746 LVTDASSA--STGQATPLPVTDTSSVSTAHATPLPVTGLSSASTDDTTRLPVTDVSSAST 1803

Query: 1042 GGLKPLAQEHGPRSALGGAREVP--DAPPAACPEVSQARLLSPAREERGLSGKSTPEPTL 1099
            G   PL       ++ G    +P  DA  A+  + +   +  P+      SG +T  P  
Sbjct: 1804 GQAIPLPVTSPSSASTGDTTPLPVTDASSASTGDTTSLPVTIPSSAS---SGHTTSLPVT 1860

Query: 1100 PSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ-QPEPVLGLGSVEQPH--- 1155
             ++  +     S   +   +VS+ D          SA T    P  V    SV   H   
Sbjct: 1861 DASSVSTGHATSLLVTDASSVSTGDTTPLPVTDTNSASTGDTTPLHVTDASSVSTGHATS 1920

Query: 1156 -EVPSVLG------TPLLQPPENLAKGQPSTPV------DRPLGPDPSAPGTLAGAALPP 1202
              V S+        TPL     + A    +TP+        P G   S P T A +    
Sbjct: 1921 LPVTSLSSASTGDTTPLPVTSPSSASSGHTTPLPVTDASSVPTGHATSLPVTDASSVSTG 1980

Query: 1203 LEPPAPCLCQDPQEDSVEDEEP-------PGSLGLPPPQAGVQPAAAAVSGTTQ-PLGTG 1254
               P P    D    S     P         S G   P      ++A+   TT  P+   
Sbjct: 1981 HATPLP--VTDASSVSTGHATPLPVTDTSSVSTGQATPLPVTSLSSASTGDTTPLPVTDT 2038

Query: 1255 PRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDS 1314
               S    +PL    ++S+   D       P  V  PS   +     G + P    D  S
Sbjct: 2039 SSASTGQDTPLPVTSLSSVSTGDTT-----PLPVTSPSSAST-----GHATPLLVTDASS 2088

Query: 1315 LEEDSPRAL---GSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGS 1361
            +      +L    +   S  H  +    D   +    T   P  +P+  S
Sbjct: 2089 VSTGHATSLLVTDASSVSTGHATALHVTDASSLSTGDTTPLPVTSPSSAS 2138



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 235/1033 (22%), Positives = 343/1033 (33%), Gaps = 130/1033 (12%)

Query: 25   SCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGA---PS 81
            S     AT +L  D          P H+      S     P P   +     G A   P 
Sbjct: 3176 SVSTGHATPLLVTDASSASTGHATPLHVTSPSSASTGDTTPVPVTDTSSVSTGHATPLPV 3235

Query: 82   AWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRD 141
                    G +  L    +SS +     PLP T    +  G+     + SP +A T    
Sbjct: 3236 TGLSSASTGDTTRLPVTDISSASTGQATPLPVTNTSSVSTGDTMPLPVTSPSSAST---- 3291

Query: 142  QEGGHASPDPPPELCSQGD-LSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDS 200
               GHA+P P     S     + P P     S  T  +TP   T           D   +
Sbjct: 3292 ---GHATPLPVTSTSSASTGHATPVPVTSTSSASTGHTTPLPVT-----------DTSSA 3337

Query: 201  EAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMV 260
                   L  + P+S S  + T    +  SS S   +   P  G    S    +P     
Sbjct: 3338 STGDTTPLPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTGASSASTGHATPLPVTD 3397

Query: 261  DERELHPAGTPEPPSSESSLSADSSS-------SWGQEGHFFDLDFLANDPMIPAALLPF 313
                     TP P +S SS+S   ++       S    G    L   +   +      P 
Sbjct: 3398 TSSVSTGHATPLPVTSLSSVSTGDTTPLPVTDASSASTGQATPLPVTSLSSVSTGDTTPL 3457

Query: 314  QGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEG 373
              +    V     TPL   +    +       GD       D++SAS  Q+ + L +T  
Sbjct: 3458 LVTDASSVSTGHATPLPVTDTSSAST------GDTTRLPVTDTSSASTGQA-TPLPVTSL 3510

Query: 374  MDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKG 433
               + +  D T    +D+ S S   A    +      +     +  V  T   S G A  
Sbjct: 3511 --SSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQATP 3568

Query: 434  LQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPG 493
            L     + S +    P      + +S        VT    A    ST  VTP  +     
Sbjct: 3569 LPVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTSPSSA----STGHVTPLPVTSTSS 3624

Query: 494  LQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQES---VTAEKLPTPQ 550
                 AT +          + A   S   A P P  +  S   G  +   VT     +  
Sbjct: 3625 ASTGHATPLLV--------TDASSVSTGHATPLPVTDASSASTGDTTPLPVTDTSSASTG 3676

Query: 551  EETSLTLCPDSPQNLKEEGGLDLPSGRKPVAA-ATIVPRQAEEDLTLPQDSAMTPPLPLQ 609
            + T L +   S  +  +   L +          AT +P      +T+P   +    +PL 
Sbjct: 3677 QATPLPVTSLSSVSTGDTTPLPVTDASSASTGHATPLP------VTIPSSVSTGDTMPLP 3730

Query: 610  DTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSA----PKPVAAATL 665
             T  SSA    A    V+     GL+       TP LP+ DT  +S     P PV   + 
Sbjct: 3731 VTSPSSASTGHATPLPVT-----GLSSASTGDTTP-LPVTDTSSASTRHATPLPVTDTSS 3784

Query: 666  VSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSA----PKPVAAATLVSQQAEEGLTLP 717
             S      L +   S+ +     PLP+  T  +S     P PV   + VS      L + 
Sbjct: 3785 ASTDDTTRLPVTDVSSASTGHATPLPVTSTSSASTGDTTPLPVTDTSSVSTGHATSLPVT 3844

Query: 718  QDSAMTP----PLPLQDTDLSSA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----P 765
              S+ +     PLP+ DT   S     P PV + + VS      L +   S+ +     P
Sbjct: 3845 SRSSASTGHATPLPVTDTSSVSTGHATPLPVTSTSSVSTGHATPLPVTSPSSASTGHATP 3904

Query: 766  LPLQDTDLSSA----PKPVAAATIVSQQAEEGL--TLPQDSAMTPPLPLQDTDLSSA--- 816
            +P+  T  +S     P PV  A+ +S      L  T P  ++      L  TD SSA   
Sbjct: 3905 VPVTSTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASRGDTSTLPVTDASSASTG 3964

Query: 817  ---PKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA------PKPVAAATPVS 867
               P P+ + + VS            +  T PLP+  TD SSA      P PV + + VS
Sbjct: 3965 HATPLPLTSLSSVS------------TGDTTPLPV--TDTSSASTGQATPLPVTSLSSVS 4010

Query: 868  QQAEEGL--TLPQ--DSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVAT 923
                  L  T+P    S  T  LP+ D    S      +    T  A  G      PV  
Sbjct: 4011 TGDTTPLPVTIPSSASSGHTTSLPVTDASSVSTGHGTPLPVTSTSSASTGDTTPL-PVTD 4069

Query: 924  MAQQEVGEALGPRPAPEEKNAAL-PTVPEP-AALDQVQQDDPQPAAEAGTPWAAQEDADS 981
             +    G A  P P  +  +A+     P P  +L  V      P A +    A+   +DS
Sbjct: 4070 TSSASTGHAT-PLPVTDTSSASTGHATPLPVTSLSSVSTGHATPLAVSSATSASTVSSDS 4128

Query: 982  TLGMEALSLPEPA 994
             L ME   +  P+
Sbjct: 4129 PLKMETPGMTTPS 4141



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 137/589 (23%), Positives = 206/589 (34%), Gaps = 91/589 (15%)

Query: 603  TPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSVM----TPPLPLQDTELS 654
            T PLP  DT   S     P  V  A+ VS      L +   S      T PLP+ DT  +
Sbjct: 2462 TTPLPGTDTSSVSTGHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVTDTPSA 2521

Query: 655  SA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSA----PKPVAA 702
            S     P PV  A+ +S +    L +   S+ +      LP+ DT  +S     P PV +
Sbjct: 2522 STGDTTPLPVTNASSLSTRHATSLHVTSPSSASTGHATSLPVTDTSAASTGHATPLPVTS 2581

Query: 703  ATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAM 762
             +  S            +  T PLP+ DT  +S  +        +  A  G         
Sbjct: 2582 TSSAS------------TGDTTPLPVTDTYSASTGQATPLPVTDTSSASTG--------D 2621

Query: 763  TPPLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSAM----TPPLPLQDTD-- 812
            T PLP+ DT  +S     P PV   + VS      L +   S+     T PLP+ D    
Sbjct: 2622 TTPLPVTDTSSASTGHATPLPVTNTSSVSTGHATPLHVTSPSSASTGHTTPLPVTDASSV 2681

Query: 813  ----LSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQ 868
                 +S P   A++          +T+P  ++     PL  TD SS     A + PV+ 
Sbjct: 2682 STGHATSLPVTDASSVFTGHATSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLPVTD 2741

Query: 869  QAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTE---PVATMA 925
             +         +    PLP+ D    S       ATP  L + +  + G     PV   +
Sbjct: 2742 ASS------VSTGHATPLPVTDASSVS----TGHATPLPLTSLSSVSTGDTTPLPVTDTS 2791

Query: 926  QQEVGEALGPRPAPEEKNAAL-PTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLG 984
                G+A  P P     + +   T P P         D   A+          D  S   
Sbjct: 2792 SASTGQAT-PLPVTSLSSVSTGDTTPLPVT-------DTSSASTGHATSLPVTDTSSAST 2843

Query: 985  MEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGL 1044
              A  LP+          +  S     A L     T   +   +      +  +   G  
Sbjct: 2844 GHATPLPD---------TDTSSASTGHATLLPVTDTSSASIGHATSLPVTDTSSISTGHA 2894

Query: 1045 KPLAQEHGPRSALGGAREVP--DAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSA 1102
             PL       ++ G A  +P  D   A+    +   + SP+      +G +TP P   ++
Sbjct: 2895 TPLHVTSPSSASTGHATPLPVTDTSSASTGHANPLHVTSPSSAS---TGHATPLPVTDTS 2951

Query: 1103 VATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQ-QPEPVLGLGS 1150
             A+       P +S+ +VS+ D       +P+SA T    P PV    S
Sbjct: 2952 SASTGHATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHTTPLPVTDTSS 3000



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 254/1180 (21%), Positives = 379/1180 (32%), Gaps = 166/1180 (14%)

Query: 90   GPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASP 149
            G + +L     SS ++     LP T    I  G  T   + SP +A T       GHA+P
Sbjct: 2860 GHATLLPVTDTSSASIGHATSLPVTDTSSISTGHATPLHVTSPSSAST-------GHATP 2912

Query: 150  DPPPELCSQGDLSV-PSPPPDPDSFFTPPSTP---TKTTYALLPACGPHGDARDSEAELR 205
             P  +  S       P     P S  T  +TP   T T+ A      P      S     
Sbjct: 2913 LPVTDTSSASTGHANPLHVTSPSSASTGHATPLPVTDTSSASTGHATPLPVTSLSSVSTG 2972

Query: 206  DE--LLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDER 263
            D   L  + P+S S  + T    +  SS S   +   P       S    +P        
Sbjct: 2973 DTTPLPVTSPSSASTGHTTPLPVTDTSSASTGQATALPVTSTSSASTGDTTPLPVTDTSS 3032

Query: 264  ELHPAGTPEPPSSESSLSAD-------SSSSWGQEGHFFDLDFLANDPMIPAALLPFQGS 316
                  TP P +S SS+S         +S S    GH   L              P   +
Sbjct: 3033 ASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSASTGQATPLPVT 3092

Query: 317  LIFQVEAVEVTPL---SPEEEEE-EAVADPDPGGDLAGEGEEDS-----TSASFLQSLSD 367
             +  V   + TPL   SP       A + P      A  G+  S     TS+++    + 
Sbjct: 3093 SLSSVSTGDTTPLPVTSPSSASTGHATSLPVTDTSSASTGDTTSLPVTDTSSAYTGDTTS 3152

Query: 368  LSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEES 427
            L +T+    +    D T    +++ S S   A    +      +        V      S
Sbjct: 3153 LPVTDTSSSSTG--DTTPLLVTETSSVSTGHATPLLVTDASSASTGHATPLHVTSPSSAS 3210

Query: 428  GGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHT 487
             G    +   D +      A P      +  S        VT+   A   ++T     +T
Sbjct: 3211 TGDTTPVPVTDTSSVSTGHATPLPVTGLSSASTGDTTRLPVTDISSASTGQATPLPVTNT 3270

Query: 488  LQVAPG--LQVEVATRVTPQAGEEE----TDSTAGQESAAMAMPQPSQEGISEILGQESV 541
              V+ G  + + V +  +   G       T +++     A  +P  S    S        
Sbjct: 3271 SSVSTGDTMPLPVTSPSSASTGHATPLPVTSTSSASTGHATPVPVTSTSSAS-------- 3322

Query: 542  TAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDL-TLPQDS 600
            T    P P  +TS     D+   L         +G       TI    +  D  TLP   
Sbjct: 3323 TGHTTPLPVTDTSSASTGDTTP-LPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTG 3381

Query: 601  AMTP------PLPLQDTDLSSA----PKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQD 650
            A +       PLP+ DT   S     P PV + + VS               T PLP+ D
Sbjct: 3382 ASSASTGHATPLPVTDTSSVSTGHATPLPVTSLSSVSTGD------------TTPLPVTD 3429

Query: 651  TELSSA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDT----------- 691
               +S     P PV + + VS      L +   S+++     PLP+ DT           
Sbjct: 3430 ASSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRL 3489

Query: 692  ---DLSSA------PKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSAPK 738
               D SSA      P PV + + VS      L +   S+++     PLP+ DT  +S   
Sbjct: 3490 PVTDTSSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGD 3549

Query: 739  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGL--TL 796
                    +  A  G   P    +   +P   +   + P PV + + VS      L  T 
Sbjct: 3550 TTRLPVTDTSSASTGQATP----LPVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTS 3605

Query: 797  PQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAE----EGLTLPQDSAM------TPPL 846
            P  ++     PL  T  SSA    A   LV+  +         LP   A       T PL
Sbjct: 3606 PSSASTGHVTPLPVTSTSSASTGHATPLLVTDASSVSTGHATPLPVTDASSASTGDTTPL 3665

Query: 847  PLQDTDLSSA----PKPVAAATPVS------------QQAEEG------LTLPQDSAMTA 884
            P+ DT  +S     P PV + + VS              A  G      +T+P   +   
Sbjct: 3666 PVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTDASSASTGHATPLPVTIPSSVSTGD 3725

Query: 885  PLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNA 944
             +PL  T P+S     A   P T  + A     T    T           P P  +  +A
Sbjct: 3726 TMPLPVTSPSSASTGHATPLPVTGLSSASTGDTTPLPVTDTSSASTRHATPLPVTDTSSA 3785

Query: 945  ALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGE-EIAE 1003
            +          D              T  ++    D+T        P P +         
Sbjct: 3786 STDDTTRLPVTDVSSASTGHATPLPVTSTSSASTGDTT--------PLPVTDTSSVSTGH 3837

Query: 1004 ALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREV 1063
            A S P     + +R+    G     P  +T  V     G   PL        + G A  +
Sbjct: 3838 ATSLP-----VTSRSSASTGHATPLPVTDTSSVST---GHATPLPVTSTSSVSTGHATPL 3889

Query: 1064 PDAPPAACPEVSQARLLSPAREERGLSGKSTPEP-----TLPSAVATEASLDSCPESSVG 1118
            P   P++      A  +         +G +TP P     +L +  AT   + S   +S G
Sbjct: 3890 PVTSPSSA-STGHATPVPVTSTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASRG 3948

Query: 1119 AVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVP 1158
              S+L    P   A +++     P P+  L SV      P
Sbjct: 3949 DTSTL----PVTDASSASTGHATPLPLTSLSSVSTGDTTP 3984



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 284/1283 (22%), Positives = 423/1283 (32%), Gaps = 171/1283 (13%)

Query: 84   ADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQE 143
            A  G+  P P+  P   SS +     PLP T    +  G  T   +    +A T      
Sbjct: 1321 ASTGDTMPLPVTSP---SSASTGDTTPLPVTDASSVSTGHTTPLHVTDASSAST------ 1371

Query: 144  GGHASPDPPPELCS--QGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACG-----PHGD 196
             G A+P P   L S   GD + P P   P S  T  +TP   T     + G     P  D
Sbjct: 1372 -GQATPLPVTSLSSVSTGD-TTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPLPVTD 1429

Query: 197  ARDSEAELRDELLDSPPASPSGSYITA--DGDSWASSPSCSLSLLAP-----AEGLDFPS 249
            A     +    L  + P++ S  + T     D+ ++S   + SLL       + G   P 
Sbjct: 1430 ASSVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPL 1489

Query: 250  GWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAA 309
                +   S      LH        +  ++    +S S    G    L   +        
Sbjct: 1490 PVTSTSSASTGHVTPLHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGD 1549

Query: 310  LLPFQGSLIFQVEAVEVTPLSPEEEEEEAVAD--PDPGGDLAGEGEEDSTSASFLQSLSD 367
              P   +    V     TPL        +     P P  D +   + D+T    L   S 
Sbjct: 1550 TTPLPVTDASSVSTGHTTPLPVTSPSSASTGHTTPLPVTDTSSASKGDTTP---LPVTSP 1606

Query: 368  LSITEGMDEAFAFRDDTSAASSDS------DSASYAEADDERLYSGEPHAQAT--LLQDS 419
             S + G        D +SA++ D+      +++S +      L+   P + +T       
Sbjct: 1607 SSASTGHTTPLPVTDTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASTGHATPLP 1666

Query: 420  VQKTEEESGGGAKGLQAQDGTVSWAVEAA--PQTSDRGAYLSQRQELISEVTEEGLALGQ 477
            V  T   S G A  L     + +   +    P T    A   Q   L   VT    +L  
Sbjct: 1667 VTSTSSASTGHATPLPVTGLSSATTDDTTRLPVTDVSSASTGQATPL--PVT----SLSS 1720

Query: 478  ESTATVTP---------HTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPS 528
             ST   TP          T   +P L  + ++  T QA       T+   S A A P P 
Sbjct: 1721 VSTGDTTPLPVTSPSSASTGHASPLLVTDASSASTGQATPLPVTDTSSV-STAHATPLP- 1778

Query: 529  QEGISEILGQESVTAEKLPTPQEETSLT-----LCPDSPQNLKEEGGLDLP---SGRKPV 580
               ++ +    +    +LP     ++ T     L   SP +        LP   +     
Sbjct: 1779 ---VTGLSSASTDDTTRLPVTDVSSASTGQAIPLPVTSPSSASTGDTTPLPVTDASSAST 1835

Query: 581  AAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDS 640
               T +P      +T+P  ++      L  TD SS     A + +V+  +         +
Sbjct: 1836 GDTTSLP------VTIPSSASSGHTTSLPVTDASSVSTGHATSLLVTDASSVS------T 1883

Query: 641  VMTPPLPLQDTELSSA----PKPVAAATLVSQQAEEGLTLPQDSAM----TPPLPLQDTD 692
              T PLP+ DT  +S     P  V  A+ VS      L +   S+     T PLP+    
Sbjct: 1884 GDTTPLPVTDTNSASTGDTTPLHVTDASSVSTGHATSLPVTSLSSASTGDTTPLPVTSPS 1943

Query: 693  LSSA----PKPVAAATLVSQQAEEGLTLPQDSAMTP----PLPLQDTDLSSA----PKPV 740
             +S+    P PV  A+ V       L +   S+++     PLP+ D    S     P PV
Sbjct: 1944 SASSGHTTPLPVTDASSVPTGHATSLPVTDASSVSTGHATPLPVTDASSVSTGHATPLPV 2003

Query: 741  AAATLVSQQAEEGLTLPQDSAM----TPPLPLQDTDLSSA----PKPVAAATIVSQQAEE 792
               + VS      L +   S+     T PLP+ DT  +S     P PV + + VS     
Sbjct: 2004 TDTSSVSTGQATPLPVTSLSSASTGDTTPLPVTDTSSASTGQDTPLPVTSLSSVSTGDTT 2063

Query: 793  GL--TLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQD 850
             L  T P  ++     PL  TD SS     A + LV+  +           +T    L  
Sbjct: 2064 PLPVTSPSSASTGHATPLLVTDASSVSTGHATSLLVTDASSVSTGHATALHVTDASSLST 2123

Query: 851  TDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQA 910
             D  + P PV + +  S            +  T PLP+ DT   S     ++    T  A
Sbjct: 2124 GD--TTPLPVTSPSSAS------------TGDTTPLPVTDTSSVSTGHATSLPVTDTSSA 2169

Query: 911  EAGCA---PGTE------------PVATMAQQEVGEALGPRPAPEEKNA----ALPTVPE 951
              G A   P T+            PV   +    G+A  P P     +A    A+P +  
Sbjct: 2170 STGHATSLPVTDTSSASTGHATPLPVTDTSSASTGQAT-PLPVTSPSSASTGHAIPLLVT 2228

Query: 952  PAALDQVQQDDPQP------AAEAGTPWAAQEDADSTLGMEALSLPEPASGA---GEEIA 1002
              +     Q  P P      A+   T      DA S     A SLP  +  +   G+   
Sbjct: 2229 DTSSASTGQATPLPVTSLSSASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVSTGDTTP 2288

Query: 1003 EALSRPGREACLEAR-AHTGDGAKPDSPQKETLEV---ENQQEGGLKPLAQEHGPRSALG 1058
              ++ P   +   A   H  D +   +     L V    +   G   PL     P SA  
Sbjct: 2289 LPVTSPSSASTGHATPLHVTDASSASTGHATPLPVTSLSSASTGDTTPLPVT-SPSSAST 2347

Query: 1059 GAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVG 1118
            G         A+         L         SG +TP P   ++ A+       P +   
Sbjct: 2348 GHATPLHVTDASSVSTGDTTPLPVTSSSSASSGHTTPLPVTDASSASTGDTTPLPVTDTS 2407

Query: 1119 AVSSLDRGCPDAPAPTSAPTSQQPE-PVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQP 1177
            + S+           +SA T      PV  + S    H       TPL     + A    
Sbjct: 2408 SASTGHATHLPVTGLSSASTGDTTRLPVTNVSSASTGH------ATPLPVTSTSSASTGD 2461

Query: 1178 STPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGV 1237
            +TP+    G D S+  T  G   P L   A  +                S G   P   V
Sbjct: 2462 TTPLP---GTDTSSVST--GHTTPLLVTDASSVSTGDTTRLPVTSPSSASTGHTTP-LPV 2515

Query: 1238 QPAAAAVSGTTQPLGTGPRVSLS 1260
                +A +G T PL      SLS
Sbjct: 2516 TDTPSASTGDTTPLPVTNASSLS 2538



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 257/1173 (21%), Positives = 380/1173 (32%), Gaps = 179/1173 (15%)

Query: 49   PSHLALTFLPSKPGARPQPEGASWDAGPGGAP------SAWADPGEGGPSPMLLPEGLSS 102
            P  +  T   S     P P   ++ A  G A       ++ A  G+  P P+      SS
Sbjct: 2576 PLPVTSTSSASTGDTTPLPVTDTYSASTGQATPLPVTDTSSASTGDTTPLPVT---DTSS 2632

Query: 103  QALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLS 162
             +     PLP T    +  G  T   + SP +A T       GH +P P  +  S     
Sbjct: 2633 ASTGHATPLPVTNTSSVSTGHATPLHVTSPSSAST-------GHTTPLPVTDASSVSTGH 2685

Query: 163  VPS-PPPDPDSFFTPPSTPTKTTYALLPACG-----PHGDARDSEAELRDELLDSPPASP 216
              S P  D  S FT  +T    T     + G     P  DA          L  +  +S 
Sbjct: 2686 ATSLPVTDASSVFTGHATSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLPVTDASSV 2745

Query: 217  SGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSS 276
            S  + T    + ASS S   +   P   L   S    +P              TP P +S
Sbjct: 2746 STGHATPLPVTDASSVSTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPLPVTS 2805

Query: 277  ESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEE 336
             SS+S   ++                        LP   +           P++      
Sbjct: 2806 LSSVSTGDTTP-----------------------LPVTDTSSASTGHATSLPVTDTSSAS 2842

Query: 337  EAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASY 396
               A P P  D +      ST  + L  ++D S       + +    TS   +D+ S S 
Sbjct: 2843 TGHATPLPDTDTSSA----STGHATLLPVTDTS-------SASIGHATSLPVTDTSSIST 2891

Query: 397  AEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGA 456
              A    + S    +        V  T   S G A  L     + +    A P      +
Sbjct: 2892 GHATPLHVTSPSSASTGHATPLPVTDTSSASTGHANPLHVTSPSSASTGHATPLPVTDTS 2951

Query: 457  YLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAG 516
              S        VT    +L   ST   TP  +  +P       T   P      TD+++ 
Sbjct: 2952 SASTGHATPLPVT----SLSSVSTGDTTPLPV-TSPSSASTGHTTPLP-----VTDTSSA 3001

Query: 517  QESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLP-S 575
                A A+P  S    S        T +  P P  +TS         +        LP +
Sbjct: 3002 STGQATALPVTSTSSAS--------TGDTTPLPVTDTS---------SASTGQATPLPVT 3044

Query: 576  GRKPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSA------PKPVAAATIVSQQ 629
                V+     P      +T P  ++     PL  TD SSA      P PV + + VS  
Sbjct: 3045 SLSSVSTGDTTPL----PVTSPSSASTGHATPLLVTDASSASTGQATPLPVTSLSSVSTG 3100

Query: 630  AEEGLTLPQDSVMT----PPLPLQDTELSSAPKPVAAATLVSQQAEEG------LTLPQD 679
                L +   S  +      LP+ DT  +S     +     +  A  G      +T    
Sbjct: 3101 DTTPLPVTSPSSASTGHATSLPVTDTSSASTGDTTSLPVTDTSSAYTGDTTSLPVTDTSS 3160

Query: 680  SAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEG--------LTLPQDSAM--TPPLPLQ 729
            S+     PL  T+ SS     A   LV+  +           +T P  ++   T P+P+ 
Sbjct: 3161 SSTGDTTPLLVTETSSVSTGHATPLLVTDASSASTGHATPLHVTSPSSASTGDTTPVPVT 3220

Query: 730  DTDLSS----APKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSA------PKP 779
            DT   S     P PV   +  S            +  T  LP+  TD+SSA      P P
Sbjct: 3221 DTSSVSTGHATPLPVTGLSSAS------------TGDTTRLPV--TDISSASTGQATPLP 3266

Query: 780  VAAATIVSQQAEEGL--TLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLP 837
            V   + VS      L  T P  ++     PL  T  SSA    A    V+       T  
Sbjct: 3267 VTNTSSVSTGDTMPLPVTSPSSASTGHATPLPVTSTSSASTGHATPVPVTS------TSS 3320

Query: 838  QDSAMTPPLPLQDTDLSS----APKPVAAATPVSQQAEEGL--TLPQDSAMTAPLPLQDT 891
              +  T PLP+ DT  +S     P PV + +  S      L  T+P  ++      L  T
Sbjct: 3321 ASTGHTTPLPVTDTSSASTGDTTPLPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVT 3380

Query: 892  GPTSGPEPLAVATPQTLQAEAGCAPGTE-PVATMAQQEVGEALGPRPAPEEKNAAL-PTV 949
            G +S     A   P T  +       T  PV +++    G+   P P  +  +A+     
Sbjct: 3381 GASSASTGHATPLPVTDTSSVSTGHATPLPVTSLSSVSTGDTT-PLPVTDASSASTGQAT 3439

Query: 950  PEP-AALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRP 1008
            P P  +L  V   D  P            DA S     A  LP         + +  S  
Sbjct: 3440 PLPVTSLSSVSTGDTTPLLVT--------DASSVSTGHATPLP---------VTDTSSAS 3482

Query: 1009 GREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPP 1068
              +        T   +   +       + +   G   PL        + G A  +P    
Sbjct: 3483 TGDTTRLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLLVTDASSVSTGHATPLPVTDT 3542

Query: 1069 AACPEVSQARLLSPAREERGLS-GKSTPEP-TLPSAVATEASLDSCPESSVGAVSSLDRG 1126
            ++       RL  P  +    S G++TP P T+PS+ ++       P +S  +VS+    
Sbjct: 3543 SSASTGDTTRL--PVTDTSSASTGQATPLPVTIPSS-SSSGHTTPLPVTSTSSVSTGHVT 3599

Query: 1127 CPDAPAPTSAPTSQ-QPEPVLGLGSVEQPHEVP 1158
                 +P+SA T    P PV    S    H  P
Sbjct: 3600 PLHVTSPSSASTGHVTPLPVTSTSSASTGHATP 3632



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 218/1005 (21%), Positives = 328/1005 (32%), Gaps = 160/1005 (15%)

Query: 382  DDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTV 441
            D T    +D+ SAS  +A    + S    +        V  T   S G A  L   D + 
Sbjct: 2781 DTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTDTSSASTGHATSLPVTDTSS 2840

Query: 442  SWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATR 501
            +    A P      +  S     +  VT+   A    +T+     T  ++ G        
Sbjct: 2841 ASTGHATPLPDTDTSSASTGHATLLPVTDTSSASIGHATSLPVTDTSSISTG-------H 2893

Query: 502  VTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDS 561
             TP      + ++ G      A P P  +  S   G  +      P+       T  P +
Sbjct: 2894 ATPLHVTSPSSASTGH-----ATPLPVTDTSSASTGHANPLHVTSPSSASTGHATPLPVT 2948

Query: 562  PQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQDSAM----TPPLPLQDTDLSSAP 617
              +    G     +   PV + + V       L +   S+     T PLP+ DT  +S  
Sbjct: 2949 DTSSASTGH----ATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHTTPLPVTDTSSASTG 3004

Query: 618  KPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSS----APKPVAAATLVSQQAEEG 673
            +  A     +  A  G         T PLP+ DT  +S     P PV + + VS      
Sbjct: 3005 QATALPVTSTSSASTG--------DTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTP 3056

Query: 674  L--TLPQDSAMTPPLPLQDTDLSSA------PKPVAAATLVSQQAEEGLTLPQDSAMT-- 723
            L  T P  ++     PL  TD SSA      P PV + + VS      L +   S+ +  
Sbjct: 3057 LPVTSPSSASTGHATPLLVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTG 3116

Query: 724  --PPLPLQDT------DLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS 775
                LP+ DT      D +S P    ++          +T    S+     PL  T+ SS
Sbjct: 3117 HATSLPVTDTSSASTGDTTSLPVTDTSSAYTGDTTSLPVTDTSSSSTGDTTPLLVTETSS 3176

Query: 776  APKPVAAATIVSQQAEEG--------LTLPQDSAM--TPPLPLQDTDLSSA--PKPVAAA 823
                 A   +V+  +           +T P  ++   T P+P+ DT   S     P+   
Sbjct: 3177 VSTGHATPLLVTDASSASTGHATPLHVTSPSSASTGDTTPVPVTDTSSVSTGHATPLPVT 3236

Query: 824  TLVSQQAEEGLTLP------QDSAMTPPLPLQDTDLSSA----PKPVAA--------ATP 865
             L S    +   LP        +    PLP+ +T   S     P PV +        ATP
Sbjct: 3237 GLSSASTGDTTRLPVTDISSASTGQATPLPVTNTSSVSTGDTMPLPVTSPSSASTGHATP 3296

Query: 866  V----SQQAEEGLTLP--------QDSAMTAPLPLQDT--GPTSGPEPLAVATPQ----- 906
            +    +  A  G   P          +  T PLP+ DT    T    PL V +P      
Sbjct: 3297 LPVTSTSSASTGHATPVPVTSTSSASTGHTTPLPVTDTSSASTGDTTPLPVTSPSSASTG 3356

Query: 907  -------TLQAEAGCA-PGTEPVATMAQQEVGEALGPRPAPEEKNAALPT---VPEP-AA 954
                   T+ + A      T PV   +    G A    P P    +++ T    P P  +
Sbjct: 3357 HTTPLHVTIPSSASTGDTSTLPVTGASSASTGHA---TPLPVTDTSSVSTGHATPLPVTS 3413

Query: 955  LDQVQQDD--PQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREA 1012
            L  V   D  P P  +A +    Q    + L + +LS           + +A S     A
Sbjct: 3414 LSSVSTGDTTPLPVTDASSASTGQA---TPLPVTSLSSVSTGDTTPLLVTDASSVSTGHA 3470

Query: 1013 CLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACP 1072
                   T   +  D+ +    +  +   G   PL     P ++L       D  P    
Sbjct: 3471 TPLPVTDTSSASTGDTTRLPVTDTSSASTGQATPL-----PVTSLSSV-STGDTTPLLVT 3524

Query: 1073 EVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPA 1132
            + S              +G +TP P   ++ A+       P +   + S+        P 
Sbjct: 3525 DASSVS-----------TGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQA----TPL 3569

Query: 1133 PTSAPTSQQ-----PEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGP 1187
            P + P+S       P PV    SV   H  P  + +P             ST    PL P
Sbjct: 3570 PVTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTSP----------SSASTGHVTPL-P 3618

Query: 1188 DPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGT 1247
              S      G A P L   A  +           +    S G   P   V   ++A +G 
Sbjct: 3619 VTSTSSASTGHATPLLVTDASSVSTGHATPLPVTDASSASTGDTTP-LPVTDTSSASTGQ 3677

Query: 1248 TQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPS 1292
              PL   P  SLS  S   +  +   DA   +     P  V  PS
Sbjct: 3678 ATPL---PVTSLSSVSTGDTTPLPVTDASSASTGHATPLPVTIPS 3719



 Score = 39.7 bits (91), Expect = 0.022
 Identities = 107/505 (21%), Positives = 159/505 (31%), Gaps = 97/505 (19%)

Query: 734  SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEG 793
            ++ PK   A        E G T   ++ ++ P       + +A  P ++  +    +++ 
Sbjct: 553  TTLPKTTGAGAQTQWTQETGTT--GEALLSSPSYSVTQMIKTATSPSSSPMLDRHTSQQI 610

Query: 794  LTLPQDSAMTPPLPLQDTDLSSAPKPVAAA---TLVSQQAEEGLTLPQDSAMTPPLPLQD 850
             T P  +  T    +  T  S    P  +    T   Q  +E  T    S MT       
Sbjct: 611  TTAPSTNHST----IHSTSTSPQESPAVSQRGHTQAPQTTQESQTTRSVSPMT------- 659

Query: 851  TDLSSAPKPVAAATPVSQQAEEGLTLPQD----SAMT--APLPLQDTGPTSGPEPLAVAT 904
             D  +   P ++ T       E   +PQD    SA T  AP P  D   T  P     A 
Sbjct: 660  -DTKTVTTPGSSFTASGHSPSE--IVPQDAPTISAATTFAPAPTGDGHTTQAPTTALQAA 716

Query: 905  PQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEK--NAALPTVPEPAAL------- 955
            P +  A  G + GT    T A       +     PE +  +A+  T P+ AA        
Sbjct: 717  PSSHDATLGPSGGTSLSKTGALTLANSVVSTPGGPEGQWTSASASTSPDTAAAMTHTHQA 776

Query: 956  ------DQVQQDDPQPA----AEAGTPWAAQEDADSTL--GMEALSL----------PEP 993
                   Q Q  +P  +      AGT   +   A  T   G E +S           P  
Sbjct: 777  ESTEASGQTQTSEPASSGSRTTSAGTATPSSSGASGTTPSGSEGISTSGETTRFSSNPSR 836

Query: 994  ASGAGEEIAEALSRPGREACLEAR----------------AHTGDGAKPDSPQKETLEVE 1037
             S   +   E LS       +                   +      +P      T    
Sbjct: 837  DSHTTQSTTELLSASASHGAIPVSTGMASSIVPGTFHPTLSEASTAGRPTGQSSPTSPSA 896

Query: 1038 NQQE-GGLKPLAQEHGPRSALGG--------AREVPDAPPAACPEVSQARLLSPAREERG 1088
            + QE   +  +AQ    R++ G         A +     P   P ++   L SP  E   
Sbjct: 897  SPQETAAISRMAQTQRTRTSRGSDTISLASQATDTFSTVPPTPPSITSTGLTSPQTETHT 956

Query: 1089 L----SGKS------TPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPT 1138
            L    SGK+      +    LP   A+ AS        V   SS+  G    P P ++P+
Sbjct: 957  LSPSGSGKTFTTALISNATPLPVTYASSASTGHTTPLHVTDASSVSTG-HATPLPVTSPS 1015

Query: 1139 S-----QQPEPVLGLGSVEQPHEVP 1158
            S       P PV    S    H  P
Sbjct: 1016 SVSTGHTTPLPVTDTSSESTGHVTP 1040


>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
          Length = 2663

 Score = 75.5 bits (184), Expect = 4e-13
 Identities = 128/560 (22%), Positives = 199/560 (35%), Gaps = 73/560 (13%)

Query: 520  AAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGL--DLPSGR 577
            AA+    PS EG+       S+ A+  P+P+ E    L P        EG L  DL +  
Sbjct: 1870 AAVVTVTPSPEGVFS-----SLQAKPSPSPRAEL---LVPSL------EGALPPDLDTSE 1915

Query: 578  KPVAAATIVPRQAE--EDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLT 635
               A A I+P +    E L     SA+    P++    S   +   A++++   +E  ++
Sbjct: 1916 DQQATAAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPS---EQALASSLIGGTSENPVS 1972

Query: 636  LPQDSVMTPPLPLQDTEL-----------SSAPKPVAAATLVSQQAEEGLTLPQDSAMTP 684
             P  S +    P +  E            S+AP P +A+       E     P  S    
Sbjct: 1973 WPVGSDLLLKSPQRFPESPKRFCPADPLHSAAPGPFSAS-------EAPYPAPPASPAPY 2025

Query: 685  PLPLQDT---DLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 741
             LP+ +    D+      V AA   S+ A        +S  +    L +  L  AP+P  
Sbjct: 2026 ALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPEAPLDVAPEPAC 2085

Query: 742  AATLVSQQAE--------EGLTLPQDSAMTPPLPLQDT------DLSSAPKPVAAATIVS 787
             A +   +A         +G           P+P  D       DL   P  +    + +
Sbjct: 2086 VAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFSLPELPLQT 2145

Query: 788  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMT---- 843
            + A +G   P + ++ PP  +       AP  +    + +  AEE   LP D A T    
Sbjct: 2146 KDAADGEAEPVEESLAPPEEMPP----GAPGVINGGDVSTVVAEEPPALPPDQASTRLPA 2201

Query: 844  --PPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLA 901
               P P  +  L  A +    A  V ++   G   P  S   AP+P +     SG +   
Sbjct: 2202 ELEPEPSGEPKLDVALEAAVEAETVPEERARGD--PDSSVEPAPVPPEQRPLGSGDQGAE 2259

Query: 902  VATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQD 961
               P    A + CAP      T+AQ +  +  GP    E   AA P    P  + Q +  
Sbjct: 2260 AEGPP---AASLCAPDGPAPNTVAQAQAADGAGPEDDTEASRAAAPAEGPPGGI-QPEAA 2315

Query: 962  DPQPAAEA-GTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHT 1020
            +P+P AEA   P   +     T     +   +   G      E    P      +AR   
Sbjct: 2316 EPKPTAEAPKAPRVEEIPQRMTRNRAQMLANQSKQGPPPSEKECAPTPAPVTRAKARGSE 2375

Query: 1021 GDGAKPDSPQKETLEVENQQ 1040
             D A+   P+K   +   QQ
Sbjct: 2376 DDDAQAQHPRKRRFQRSTQQ 2395



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 164/751 (21%), Positives = 258/751 (34%), Gaps = 106/751 (14%)

Query: 694  SSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLS-SAPKPVAAATLV----SQ 748
            S  PK    A       ++GL +P         P +D  L  S P P AA   +      
Sbjct: 1615 SGDPKLKEKAKPADDGRKKGLDIPAKKPPGLDPPFKDKKLKESTPIPPAAENKLHPASGA 1674

Query: 749  QAEEGLTLPQDSAMTPPLPLQDTDL-SSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLP 807
             +++ L  P    + P  P  D    +  P P +  +  S   EE +  P+    TP   
Sbjct: 1675 DSKDWLAGPHMKEVLPASPRPDQSRPTGVPTPTSVLSCPSY--EEVMHTPR----TPSCS 1728

Query: 808  LQD--------------TDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDL 853
              D              T + +AP    + +   + +     L ++++  P  PL  T+L
Sbjct: 1729 ADDYADLVFDCADSQHSTPVPTAPTSACSPSFFDRFSVASSGLSENASQAPARPLS-TNL 1787

Query: 854  SSAPKPVAAATP-----VSQQAEEGLTLPQDSAMTAPLP--LQDTGPTSG--PEPLAVAT 904
              +       TP     V  +     ++P  S+  +P+P  ++D  P      E  A  +
Sbjct: 1788 YRSVSVDIRRTPEEEFSVGDKLFRQQSVPAASSYDSPMPPSMEDRAPLPPVPAEKFACLS 1847

Query: 905  PQTLQAEAG----------CAPGTEPVATMAQQEVGEALGPRPAPEEKNAAL-PTVPEPA 953
            P     + G          C P      T + + V  +L  +P+P  +   L P++    
Sbjct: 1848 PGYYSPDYGLPSPKVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGAL 1907

Query: 954  ALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREAC 1013
              D    +D Q  A    P  +  +        A+   EP   A          P  +A 
Sbjct: 1908 PPDLDTSEDQQATAAIIPPEPSYLEPLDEGPFSAVITEEPVEWA---------HPSEQA- 1957

Query: 1014 LEARAHTGDGAKPDS-PQKETLEVENQQEGGLKP--LAQEHGPRSALGGAREVPDAPPAA 1070
            L +    G    P S P    L +++ Q     P          SA  G     +AP  A
Sbjct: 1958 LASSLIGGTSENPVSWPVGSDLLLKSPQRFPESPKRFCPADPLHSAAPGPFSASEAPYPA 2017

Query: 1071 CPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPD- 1129
             P  S A    P  E  GL         +P+A++T  +    P S + +  S  +  P+ 
Sbjct: 2018 -PPASPAPYALPVAEP-GLEDVKDGVDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPEA 2075

Query: 1130 ----APAPTSAPTSQQPEPV-----------LGLGSVEQPHEVPSVLGTPLLQPPENLAK 1174
                AP P       Q E +            GL  + Q   VP         P ++L  
Sbjct: 2076 PLDVAPEPACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVP--WADAFAGPEDDLDL 2133

Query: 1175 GQPSTPVDRPLGPDPSAPG---TLAGAALPPLE--PPAPCLCQDPQEDSVEDEEPPGSLG 1229
            G  S P + PL    +A G    +  +  PP E  P AP +       +V  EEPP    
Sbjct: 2134 GPFSLP-ELPLQTKDAADGEAEPVEESLAPPEEMPPGAPGVINGGDVSTVVAEEPP---A 2189

Query: 1230 LPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVP 1289
            LPP QA  +  A       +P G  P++ ++  + + +  V    A+      + P  VP
Sbjct: 2190 LPPDQASTRLPAEL---EPEPSGE-PKLDVALEAAVEAETVPEERARGDPDSSVEPAPVP 2245

Query: 1290 PPSGPQSPAGPQGLSAPEQQEDEDSL---EEDSPRALGSGQHSDSHGESSAELDEQDILA 1346
            P    Q P G     A  +     SL   +  +P  +   Q +D  G        +D   
Sbjct: 2246 P---EQRPLGSGDQGAEAEGPPAASLCAPDGPAPNTVAQAQAADGAG-------PEDDTE 2295

Query: 1347 PQTVQCPAQAPAGGSEETIAKAKQSRSEKKA 1377
                  PA+ P GG +   A+ K +    KA
Sbjct: 2296 ASRAAAPAEGPPGGIQPEAAEPKPTAEAPKA 2326



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 88/374 (23%), Positives = 131/374 (35%), Gaps = 55/374 (14%)

Query: 13   PEADRPGPRTD-LSCDAAAATTILGGDRREPCALT--PGPSHLALTFLPSKPGARPQPEG 69
            P+   P P+ D L C  AA  T+         +L   P PS  A   +PS  GA P    
Sbjct: 1853 PDYGLPSPKVDALHCPPAAVVTVTPSPEGVFSSLQAKPSPSPRAELLVPSLEGALPPDLD 1912

Query: 70   ASWDAGPGGA----PSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEET 125
             S D     A      ++ +P + GP   ++ E     A  +E  L ++L     +G  +
Sbjct: 1913 TSEDQQATAAIIPPEPSYLEPLDEGPFSAVITEEPVEWAHPSEQALASSL-----IGGTS 1967

Query: 126  CQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTY 185
               +  P  +   L+  +     P+ P   C    L   +P P   S    P+ P     
Sbjct: 1968 ENPVSWPVGSDLLLKSPQ---RFPESPKRFCPADPLHSAAPGPFSASEAPYPAPPASPAP 2024

Query: 186  ALLPACGPH-GDARDSEAELRDELLDS---PPASPSG---------SYITADGDSWASSP 232
              LP   P   D +D    +   +  S   P A PSG         S   A  D  A  P
Sbjct: 2025 YALPVAEPGLEDVKDGVDAVPAAISTSEAAPYAPPSGLESFFSNCKSLPEAPLDV-APEP 2083

Query: 233  SC-----SLSLLAPAEGLDFPSGWGLSPQGSM------------VDERELHPAGTPEPPS 275
            +C      +  L P E        GLS  G +             D+ +L P   PE P 
Sbjct: 2084 ACVAAVAQVEALGPLENSFLDGSRGLSHLGQVEPVPWADAFAGPEDDLDLGPFSLPELP- 2142

Query: 276  SESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEE 335
             ++  +AD  +   +E           + M P A     G  +  V A E   L P++  
Sbjct: 2143 LQTKDAADGEAEPVEE------SLAPPEEMPPGAPGVINGGDVSTVVAEEPPALPPDQAS 2196

Query: 336  EE--AVADPDPGGD 347
                A  +P+P G+
Sbjct: 2197 TRLPAELEPEPSGE 2210


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 855

 Score = 75.1 bits (183), Expect = 5e-13
 Identities = 161/689 (23%), Positives = 224/689 (32%), Gaps = 126/689 (18%)

Query: 470  EEGLALGQEST-----ATVTPHTLQVAPGLQVEVA--TRVTPQAGEEETDSTAGQE---- 518
            ++GL +  E T     AT  P    ++ G + + +  T  TP          AG E    
Sbjct: 131  QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP 190

Query: 519  -SAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGR 577
              A  A P+P  EG  + +   S  +   P+P             +     GGL  P+ R
Sbjct: 191  RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAAR----------RRPSAGGGLQRPASR 240

Query: 578  KPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLP 637
               ++AT +   A         +  TP  P       S PKP     +   Q    +T P
Sbjct: 241  SLSSSATPLSSPARSG----PSARGTPRAPAHP----SQPKPKGLQALRPPQ----VTPP 288

Query: 638  QDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMT----------PPLP 687
            +        PL  + L++   P  +A L SQ        P  S++T          PP P
Sbjct: 289  RKDAAPALGPLSSSPLAT---PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP 345

Query: 688  LQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVS 747
                 L + P P A       QA   L  P   A    LP       + P P A   L  
Sbjct: 346  SAPPSLQTLPSPPATPP---SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL-- 400

Query: 748  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATI---VSQQAEEGLTLPQDSAMTP 804
              A   L  P     +PPL    T    AP  +A   +    S      +  P     +P
Sbjct: 401  --ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458

Query: 805  PLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAAT 864
            P+    T  S AP  +AA  L          +P     +PP+    T    AP P+AA  
Sbjct: 459  PVSPSATPPSQAPPSLAAPPL---------QVPPSPPASPPMSPSATPPPQAPPPLAAP- 508

Query: 865  PVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATP--QTLQAEAGCAPGTEPVA 922
                                PL L    P + P   A+ATP  Q L +     PG  P +
Sbjct: 509  --------------------PLQLAKPPPQAPP---ALATPPLQALPSPPASFPGQAPFS 545

Query: 923  TMAQQEVGEALGPRP-APEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADS 981
              A   +     P P AP    A L  VP         Q   +P      P    + + S
Sbjct: 546  PSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP------PTPGPDTSVS 599

Query: 982  TLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQE 1041
               +     P P        +  LS P            G  +   S  +E    ++  E
Sbjct: 600  GPRLTLALAPGPPPPPSRSPSSTLSGPDL---------AGHSSSATSTPEELRGYDSGPE 650

Query: 1042 GGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEP--TL 1099
            GG                A   PDA  AAC   + +R  +P    RG  G   P P  T 
Sbjct: 651  GG--------------AAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 696

Query: 1100 PSAVATEASL--DSCPESSVGAVSSLDRG 1126
            P +     ++     PES+  A  +LD G
Sbjct: 697  PGSADGLCTIYETEGPESATPAPGALDPG 725



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 129/535 (24%), Positives = 180/535 (33%), Gaps = 93/535 (17%)

Query: 800  SAMTPPLPLQDTDLS-SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 858
            S  T P PL    L  SA + VA            L+       + P P         P 
Sbjct: 121  SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-------GTPS 173

Query: 859  PVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT 918
            P  A    +   E GL  P  SA   P       PT GP     +  +    E   A   
Sbjct: 174  PAMARRSRAAGTEVGLPRPAPSARPRP-------PTEGPRKSVSSASEHSTTEPSPAARR 226

Query: 919  EPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQED 978
             P A    Q        RPA    +++   +  PA      +  P+  A    P      
Sbjct: 227  RPSAGGGLQ--------RPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP------ 272

Query: 979  ADSTLGMEALSLPE-------PASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQK 1031
                 G++AL  P+        A   G   +  L+ P   A L+++A       P +P  
Sbjct: 273  --KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP---TLPATPHS 327

Query: 1032 ETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERG--- 1088
             +L  +      L P      P  +   + +   +PPA  P  +   L SP  +      
Sbjct: 328  SSLTCQLATPLPLAP------PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFL 381

Query: 1089 ----LSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTS-----APTS 1139
                LS  +TP P  P A+A           +   +S L    P AP   +     AP S
Sbjct: 382  PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 441

Query: 1140 QQPEPVLGLGSVEQPHEVP-----SVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGT 1194
              P P      V+ P   P     S   TP  Q P +LA    + P+  P  P P A   
Sbjct: 442  PPPSP-----PVQAPFSPPASPPVSPSATPPSQAPPSLA----APPLQVP--PSPPASPP 490

Query: 1195 LAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTG 1254
            ++ +A PP + P P               PP  L  PPPQA    A   +     P  + 
Sbjct: 491  MSPSATPPPQAPPPLAA------------PPLQLAKPPPQAPPALATPPLQALPSPPASF 538

Query: 1255 P-RVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQ 1308
            P +   SP + L    +A+   +   +   P  QV PPS P SP     L AP +
Sbjct: 539  PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV-PPSPPASPT----LQAPRR 588



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 149/579 (25%), Positives = 189/579 (32%), Gaps = 82/579 (14%)

Query: 480  TATVTPHTLQVAP-GLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQ 538
            T     H  Q  P GLQ     +VTP   ++   +     S+ +A P PS          
Sbjct: 262  TPRAPAHPSQPKPKGLQALRPPQVTPPR-KDAAPALGPLSSSPLATPSPSA-------AL 313

Query: 539  ESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAEEDLTLPQ 598
            +S     LP     +SLT    +P  L        PS +   +     P QA   L  P 
Sbjct: 314  QSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPT 373

Query: 599  DSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK 658
              A    LP       + P P A   +    A   L  P     +PPL    T    AP 
Sbjct: 374  LQATHSFLPSPPLSPLATPPPQAPPAL----ALPPLQAPPSPPASPPLSPLATPSPQAPN 429

Query: 659  PVAAATL---VSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLT 715
             +A   L    S      +  P     +PP+    T  S AP  +AA  L          
Sbjct: 430  ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL---------Q 480

Query: 716  LPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSS 775
            +P     +PP+    T    AP P+AA  L  Q A+     P   A TPPL      L S
Sbjct: 481  VPPSPPASPPMSPSATPPPQAPPPLAAPPL--QLAKPPPQAPPALA-TPPLQA----LPS 533

Query: 776  APKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLT 835
             P         S  A    +LP     TPP          AP PV AA L+        +
Sbjct: 534  PPASFPGQAPFSPSA----SLPMSPLATPP--------PQAP-PVLAAPLLQVPPSPPAS 580

Query: 836  LPQDSAMTPPLPLQDTDLSS---------APKPVAAATPVSQQAEEGLTLPQDSAMTAPL 886
                +   PP P  DT +S           P P  + +P S  +   L     SA + P 
Sbjct: 581  PTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPE 640

Query: 887  PLQDTGPTSGPEPLAVATPQTLQAEAGCAPGT---EPVATMAQQEVGEALGPRPAPE--- 940
             L+  G  SGPE  A A+P      A C P      P   +A +  G    P P P    
Sbjct: 641  ELR--GYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFR--GAPGAPLPWPPATG 696

Query: 941  -----------EKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALS 989
                       E        P P ALD      P P    G   A      S+   +   
Sbjct: 697  PGSADGLCTIYETEGPESATPAPGALD----PGPSPGTSGGKAAAGAGAGASSRSPKQAR 752

Query: 990  LPEPASGA--GEEIAEALSRPGREACLEARAHTGDGAKP 1026
            L E   GA     +   LSR    A  E  A  G G  P
Sbjct: 753  LGELPLGALQASVVQHLLSRTLLLAAAEGAA-GGSGGGP 790



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 202/856 (23%), Positives = 278/856 (32%), Gaps = 159/856 (18%)

Query: 600  SAMTPPLPLQDTDLS-SAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPK 658
            S  T P PL    L  SA + VA            L+       + P P         P 
Sbjct: 121  SGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-------GTPS 173

Query: 659  PVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ 718
            P  A    +   E GL  P  SA   P P +    S           VS  +E   T P 
Sbjct: 174  PAMARRSRAAGTEVGLPRPAPSARPRP-PTEGPRKS-----------VSSASEHSTTEPS 221

Query: 719  DSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPK 778
             +A   P         ++    ++AT +S  A  G      +  TP  P       S PK
Sbjct: 222  PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG----PSARGTPRAPAHP----SQPK 273

Query: 779  PVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQ 838
            P     +   Q    +T P+  A     PL  + L++   P  +A L SQ        P 
Sbjct: 274  PKGLQALRPPQ----VTPPRKDAAPALGPLSSSPLAT---PSPSAALQSQAPPTLPATPH 326

Query: 839  DSAMT----PPLPLQDTDLSSAPK----PVAAATPVSQQAEEGLTLPQDSAMTAPLPLQD 890
             S++T     PLPL     S+ P     P   ATP SQ A   L  P   A  + LP   
Sbjct: 327  SSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQ-ATTSLGSPTLQATHSFLPSPP 385

Query: 891  TGPTSGPEPLA---VATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAAL- 946
              P + P P A   +A P  LQA     P + P++ +A           P+P+  NA   
Sbjct: 386  LSPLATPPPQAPPALALPP-LQAPPS-PPASPPLSPLAT----------PSPQAPNALAV 433

Query: 947  -----PTVPEPAALDQVQQDDPQ--PAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGE 999
                 P  P P+   Q     P   P + + TP      A  +L    L +P P+  A  
Sbjct: 434  HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP---PSQAPPSLAAPPLQVP-PSPPASP 489

Query: 1000 EIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGG 1059
             ++ + + P  +A     A     AKP       L           PL     P ++  G
Sbjct: 490  PMSPSATPPP-QAPPPLAAPPLQLAKPPPQAPPALATP--------PLQALPSPPASFPG 540

Query: 1060 AREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGA 1119
              + P +P A+ P                +S  +TP P  P  +A  A L   P S    
Sbjct: 541  --QAPFSPSASLP----------------MSPLATPPPQAPPVLA--APLLQVPPSPP-- 578

Query: 1120 VSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPST 1179
             +S     P  P PT  P +    P L L     P   PS   +  L  P+       +T
Sbjct: 579  -ASPTLQAPRRP-PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT 636

Query: 1180 PVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQP 1239
                 L    S P   A A+ PP    A C                             P
Sbjct: 637  STPEELRGYDSGPEGGAAASPPPDAELAAC----------------------------HP 668

Query: 1240 AAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAG 1299
            AA +  G   PL        +P +PL  P      + D        C +    GP+S   
Sbjct: 669  AAWS-RGPAPPLA----FRGAPGAPLPWPPATGPGSAD------GLCTIYETEGPESATP 717

Query: 1300 PQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDE-----------QDILAPQ 1348
              G   P               A G+G  + S     A L E           Q +L+  
Sbjct: 718  APGALDPGPSPGTSG----GKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRT 773

Query: 1349 TVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIA 1408
             +   A+  AGGS      A+       AR A+S   L +   +     +   +I  V +
Sbjct: 774  LLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTS 833

Query: 1409 -KPDVFKSPASDTYVV 1423
              PD   SP  D  VV
Sbjct: 834  FSPDDVASPQGDWTVV 849



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 72/295 (24%), Positives = 98/295 (33%), Gaps = 25/295 (8%)

Query: 1043 GLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSA 1102
            G KPLA+  G    +GGA  +P++ P A P  S              SG+    P   + 
Sbjct: 54   GRKPLAERAG---GIGGAT-IPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNT 109

Query: 1103 VATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLG 1162
                      P SS G  S   R     P           E V    + E P    S L 
Sbjct: 110  -------SPGPVSSPGRASGTTR---PGPLGQKGLRISAEETVARGKATEAPKR--SALS 157

Query: 1163 TPLLQPPENLAKGQPSTPV---DRPLGPDPSAPGTLAGAA-LPPLEPPAPCLCQDPQEDS 1218
                +       G PS  +    R  G +   P     A   PP E P   +    +  +
Sbjct: 158  AGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHST 217

Query: 1219 VEDEEPPGSLGLPPPQAGVQ-PAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKD 1277
             E    P +   P    G+Q PA+ ++S +  PL +  R   S      +P   S   K 
Sbjct: 218  TEPS--PAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQP-KP 274

Query: 1278 LALQIL-PPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDS 1331
              LQ L PP   PP        GP   S         +L+  +P  L +  HS S
Sbjct: 275  KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 86/368 (23%), Positives = 120/368 (32%), Gaps = 67/368 (18%)

Query: 27  DAAAATTILGGDRREPCALTPGPSHLALTF----------LPSK-PGARPQP-------- 67
           +A   + +  G RR+    TPG    A+            LP   P ARP+P        
Sbjct: 149 EAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS 208

Query: 68  -EGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETC 126
              AS  +    +P+A   P  GG         LSS A    +P  +    R        
Sbjct: 209 VSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH 268

Query: 127 QALLSPRAARTALRDQEGGHASPDPPPEL--CSQGDLSVPSPPPDPDSFFTP--PSTPTK 182
            +   P+  + ALR  +      D  P L   S   L+ PSP     S   P  P+TP  
Sbjct: 269 PSQPKPKGLQ-ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHS 327

Query: 183 TTYAL-----LPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGD-------SWAS 230
           ++        LP   P   A  S      + L SPPA+P     T+ G        S+  
Sbjct: 328 SSLTCQLATPLPLAPPSPSAPPSL-----QTLPSPPATPPSQATTSLGSPTLQATHSFLP 382

Query: 231 SPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQ 290
           SP  S     P +    P    L P    +      PA  P  P +  S  A ++ +   
Sbjct: 383 SPPLSPLATPPPQA---PPALALPP----LQAPPSPPASPPLSPLATPSPQAPNALAV-- 433

Query: 291 EGHFFDLDFL--------------ANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEE 336
             H     F               A+ P+ P+A  P Q         ++V P  P     
Sbjct: 434 --HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPM 491

Query: 337 EAVADPDP 344
              A P P
Sbjct: 492 SPSATPPP 499



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 74/262 (28%), Positives = 90/262 (34%), Gaps = 41/262 (15%)

Query: 31  ATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPG--GAPSAWADPGE 88
           ATT LG         T   +H  L   P  P A P P+     A P     PS  A P  
Sbjct: 365 ATTSLGSP-------TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 417

Query: 89  GGPSPMLLPEGLSSQALST---EAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGG 145
              SP+  P   +  AL+    +AP      P +       QA  SP A+          
Sbjct: 418 ---SPLATPSPQAPNALAVHLLQAPFSPPPSPPV-------QAPFSPPASPPV-----SP 462

Query: 146 HASP--DPPPELCSQGDLSVPSPPPDPD---SFFTPPSTPTKTTYALLPACGPHGDARDS 200
            A+P    PP L +      PSPP  P    S   PP  P       L    P   A  +
Sbjct: 463 SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA 522

Query: 201 EAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAP----AEGLDFPSGWGLSPQ 256
            A    + L SPPAS  G    +   S   SP  +    AP    A  L  P     SP 
Sbjct: 523 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPP----SPP 578

Query: 257 GSMVDERELHPAGTPEPPSSES 278
            S   +    P  TP P +S S
Sbjct: 579 ASPTLQAPRRPP-TPGPDTSVS 599


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
          Length = 816

 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 160/615 (26%), Positives = 211/615 (34%), Gaps = 118/615 (19%)

Query: 738  KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQ--AEE--- 792
            K  AAA   + +A   LT     +  PP P+    L    + + AA  V ++  AE    
Sbjct: 9    KAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAAL----RVLGAAGAVGRKPLAERAGG 64

Query: 793  --GLTLPQDSAMTPPLPLQDTDLSSAPK--PVAAATLVSQQAEEGLTLPQDSAMTPPLPL 848
              G T+P+ +    P        S   +  P A  T     +  G    + S  T P PL
Sbjct: 65   IGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPG----RASGTTRPGPL 120

Query: 849  QDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTL 908
                L  + +   A    ++        P+ SA++A      +GPT G       TP   
Sbjct: 121  GQKGLRISAEETVARGKATEA-------PKRSALSAGARRDTSGPTPG-------TPSPA 166

Query: 909  QAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAE 968
             A    A GTE         VG    PRPAP    +A P  P       V         E
Sbjct: 167  MARRSRAAGTE---------VGL---PRPAP----SARPRPPTEGPRKSVSSASEHSTTE 210

Query: 969  AGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDS 1028
               P  A     S  G     L  PAS +    A  LS P R     AR      A P  
Sbjct: 211  ---PSPAARRRPSAGG----GLQRPASRSLSSSATPLSSPARSGP-SARGTPRAPAHPSQ 262

Query: 1029 PQKETLEVEN--QQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSP---- 1082
            P+ + L+     Q     K  A   GP S+   A   P APP+     S   L SP    
Sbjct: 263  PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATP 322

Query: 1083 ---AREERG---------------LSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLD 1124
               A    G               LS  +TP P  P A+A           +   +S L 
Sbjct: 323  PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLA 382

Query: 1125 RGCPDAPAPTS-----APTSQQPEPVLGLGSVEQPHEVP-----SVLGTPLLQPPENLAK 1174
               P AP   +     AP S  P P      V+ P   P     S   TP  Q P +LA 
Sbjct: 383  TPSPQAPNALAVHLLQAPFSPPPSP-----PVQAPFSPPASPPVSPSATPPSQAPPSLA- 436

Query: 1175 GQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQ 1234
               + P+  P  P P A   ++ +A PP + P P               PP  L  PPPQ
Sbjct: 437  ---APPLQVP--PSPPASPPMSPSATPPPQAPPPLAA------------PPLQLAKPPPQ 479

Query: 1235 AGVQPAAAAVSGTTQPLGTGP-RVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSG 1293
            A    A   +     P  + P +   SP + L    +A+   +   +   P  QV PPS 
Sbjct: 480  APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV-PPSP 538

Query: 1294 PQSPAGPQGLSAPEQ 1308
            P SP     L AP +
Sbjct: 539  PASPT----LQAPRR 549



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 158/679 (23%), Positives = 217/679 (31%), Gaps = 136/679 (20%)

Query: 470  EEGLALGQEST-----ATVTPHTLQVAPGLQVEVA--TRVTPQAGEEETDSTAGQE---- 518
            ++GL +  E T     AT  P    ++ G + + +  T  TP          AG E    
Sbjct: 122  QKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLP 181

Query: 519  -SAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGR 577
              A  A P+P  EG  + +   S  +   P+P             +     GGL  P+ R
Sbjct: 182  RPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAAR----------RRPSAGGGLQRPASR 231

Query: 578  KPVAAATIVPRQAEEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLP 637
               ++AT +   A         +  TP  P       S PKP            +GL   
Sbjct: 232  SLSSSATPLSSPARSG----PSARGTPRAPAHP----SQPKP------------KGLQAL 271

Query: 638  QDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAP 697
            +   +TPP                AA  +   +   L  P  SA  PP P     L + P
Sbjct: 272  RPPQVTPPRK-------------DAAPALGPLSSSPLATPSPSA--PPSPSAPPSLQTLP 316

Query: 698  KPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLP 757
             P A       QA   L  P   A    LP       + P P A   L    A   L  P
Sbjct: 317  SPPATPP---SQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPAL----ALPPLQAP 369

Query: 758  QDSAMTPPLPLQDTDLSSAPKPVAAATI---VSQQAEEGLTLPQDSAMTPPLPLQDTDLS 814
                 +PPL    T    AP  +A   +    S      +  P     +PP+    T  S
Sbjct: 370  PSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS 429

Query: 815  SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGL 874
             AP  +AA  L          +P     +PP+    T    AP P+AA            
Sbjct: 430  QAPPSLAAPPL---------QVPPSPPASPPMSPSATPPPQAPPPLAAP----------- 469

Query: 875  TLPQDSAMTAPLPLQDTGPTSGPEPLAVATP--QTLQAEAGCAPGTEPVATMAQQEVGEA 932
                      PL L    P + P   A+ATP  Q L +     PG  P +  A   +   
Sbjct: 470  ----------PLQLAKPPPQAPP---ALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 516

Query: 933  LGPRP-APEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLP 991
              P P AP    A L  VP         Q   +P      P    + + S   +     P
Sbjct: 517  ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP------PTPGPDTSVSGPRLTLALAP 570

Query: 992  EPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEH 1051
             P        +  LS P            G  +   S  +E    ++  EGG        
Sbjct: 571  GPPPPPSRSPSSTLSGPDL---------AGHSSSATSTPEELRGYDSGPEGG-------- 613

Query: 1052 GPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEP--TLPSAVATEASL 1109
                    A   PDA  AAC   + +R  +P    RG  G   P P  T P +     ++
Sbjct: 614  ------AAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTI 667

Query: 1110 --DSCPESSVGAVSSLDRG 1126
                 PES+  A  +LD G
Sbjct: 668  YETEGPESATPAPGALDPG 686



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 142/567 (25%), Positives = 190/567 (33%), Gaps = 86/567 (15%)

Query: 498  VATRVTPQAGEEETDSTAGQESAAMAMP-QPSQEGISEILGQESVTAEKLPTPQEETSLT 556
            +++  TP +    +  +A     A A P QP  +G+      +++   ++  P+++ +  
Sbjct: 233  LSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGL------QALRPPQVTPPRKDAAPA 286

Query: 557  LCPDSPQNLKEEGGLDLPSGRKPVAAATIV------PRQAEEDLTLPQDSAMTPPLPLQD 610
            L P S   L        PS   P +  T+       P QA   L  P   A    LP   
Sbjct: 287  LGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPP 346

Query: 611  TDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATL---VS 667
                + P P A   +    A   L  P     +PPL    T    AP  +A   L    S
Sbjct: 347  LSPLATPPPQAPPAL----ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS 402

Query: 668  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 727
                  +  P     +PP+    T  S AP  +AA  L          +P     +PP+ 
Sbjct: 403  PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL---------QVPPSPPASPPMS 453

Query: 728  LQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVS 787
               T    AP P+AA  L  Q A+     P   A TPPL      L S P         S
Sbjct: 454  PSATPPPQAPPPLAAPPL--QLAKPPPQAPPALA-TPPLQA----LPSPPASFPGQAPFS 506

Query: 788  QQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLP 847
              A    +LP     TPP          AP PV AA L+        +    +   PP P
Sbjct: 507  PSA----SLPMSPLATPP--------PQAP-PVLAAPLLQVPPSPPASPTLQAPRRPPTP 553

Query: 848  LQDTDLSS---------APKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPE 898
              DT +S           P P  + +P S  +   L     SA + P  L+  G  SGPE
Sbjct: 554  GPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELR--GYDSGPE 611

Query: 899  PLAVATPQTLQAEAGCAPGT---EPVATMAQQEVGEALGPRPAPE--------------E 941
              A A+P      A C P      P   +A +  G    P P P               E
Sbjct: 612  GGAAASPPPDAELAACHPAAWSRGPAPPLAFR--GAPGAPLPWPPATGPGSADGLCTIYE 669

Query: 942  KNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGA--GE 999
                    P P ALD      P P    G   A      S+   +   L E   GA    
Sbjct: 670  TEGPESATPAPGALD----PGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQAS 725

Query: 1000 EIAEALSRPGREACLEARAHTGDGAKP 1026
             +   LSR    A  E  A  G G  P
Sbjct: 726  VVQHLLSRTLLLAAAEGAA-GGSGGGP 751



 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 195/816 (23%), Positives = 264/816 (32%), Gaps = 155/816 (18%)

Query: 643  TPPLPLQDTELS-SAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVA 701
            T P PL    L  SA + VA            L+       + P P         P P  
Sbjct: 115  TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTP-------GTPSPAM 167

Query: 702  AATLVSQQAEEGLTLPQDSAMT-PPLPLQDTDLSSA-------PKPVAAATLVSQQAEEG 753
            A    +   E GL  P  SA   PP       +SSA       P P A        A  G
Sbjct: 168  ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRR---PSAGGG 224

Query: 754  LTLPQD---SAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQD 810
            L  P     S+   PL        SA     A    SQ   +GL   +   +TPP     
Sbjct: 225  LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK--- 281

Query: 811  TDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQA 870
             D + A  P++++ L +         P  SA  PP P     L + P P   ATP SQ A
Sbjct: 282  -DAAPALGPLSSSPLAT---------PSPSA--PPSPSAPPSLQTLPSP--PATPPSQ-A 326

Query: 871  EEGLTLPQDSAMTAPLPLQDTGPTSGPEPLA---VATPQTLQAEAGCAPGTEPVATMAQQ 927
               L  P   A  + LP     P + P P A   +A P  LQA     P + P++ +A  
Sbjct: 327  TTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP-LQAPPS-PPASPPLSPLAT- 383

Query: 928  EVGEALGPRPAPEEKNAAL------PTVPEPAALDQVQQDDPQ--PAAEAGTPWAAQEDA 979
                     P+P+  NA        P  P P+   Q     P   P + + TP      A
Sbjct: 384  ---------PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP---PSQA 431

Query: 980  DSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQ 1039
              +L    L +P P+  A   ++ + + P  +A     A     AKP       L     
Sbjct: 432  PPSLAAPPLQVP-PSPPASPPMSPSATPPP-QAPPPLAAPPLQLAKPPPQAPPALATP-- 487

Query: 1040 QEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTL 1099
                  PL     P ++  G  + P +P A+ P                +S  +TP P  
Sbjct: 488  ------PLQALPSPPASFPG--QAPFSPSASLP----------------MSPLATPPPQA 523

Query: 1100 PSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPS 1159
            P  +A  A L   P S     +S     P  P PT  P +    P L L     P   PS
Sbjct: 524  PPVLA--APLLQVPPSPP---ASPTLQAPRRP-PTPGPDTSVSGPRLTLALAPGPPPPPS 577

Query: 1160 VLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSV 1219
               +  L  P+       +T     L    S P   A A+ PP    A C          
Sbjct: 578  RSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAAC---------- 627

Query: 1220 EDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLA 1279
                               PAA +  G   PL        +P +PL  P      + D  
Sbjct: 628  ------------------HPAAWS-RGPAPPLA----FRGAPGAPLPWPPATGPGSAD-- 662

Query: 1280 LQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAEL 1339
                  C +    GP+S     G   P               A G+G  + S     A L
Sbjct: 663  ----GLCTIYETEGPESATPAPGALDPGPSPGTSG----GKAAAGAGAGASSRSPKQARL 714

Query: 1340 DE-----------QDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQ 1388
             E           Q +L+   +   A+  AGGS      A+       AR A+S   L +
Sbjct: 715  GELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGGARAALSDAELGR 774

Query: 1389 IQGVTRITIQKSKNILFVIA-KPDVFKSPASDTYVV 1423
               +     +   +I  V +  PD   SP  D  VV
Sbjct: 775  WAELLSPLDESRASITSVTSFSPDDVASPQGDWTVV 810



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 76/342 (22%), Positives = 108/342 (31%), Gaps = 45/342 (13%)

Query: 27  DAAAATTILGGDRREPCALTPGPSHLALTF----------LPSK-PGARPQP-------- 67
           +A   + +  G RR+    TPG    A+            LP   P ARP+P        
Sbjct: 140 EAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKS 199

Query: 68  -EGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETC 126
              AS  +    +P+A   P  GG         LSS A    +P  +    R        
Sbjct: 200 VSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAH 259

Query: 127 QALLSPRAARTALRDQEGGHASPDPPPEL--CSQGDLSVPSP--PPDPDSFFTPPSTPTK 182
            +   P+  + ALR  +      D  P L   S   L+ PSP  PP P +   PPS  T 
Sbjct: 260 PSQPKPKGLQ-ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA---PPSLQTL 315

Query: 183 TTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPA 242
            +    P             +     L SPP SP  +       + A  P  +     P+
Sbjct: 316 PSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQA----PPS 371

Query: 243 EGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLAN 302
                P     +P     +   +H    P  P     + A  S               A+
Sbjct: 372 PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPP-------------AS 418

Query: 303 DPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDP 344
            P+ P+A  P Q         ++V P  P        A P P
Sbjct: 419 PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPP 460



 Score = 38.1 bits (87), Expect = 0.065
 Identities = 51/212 (24%), Positives = 75/212 (35%), Gaps = 32/212 (15%)

Query: 13  PEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASW 72
           P     GPR  +S  +  +TT             P P   A    PS  G   +P   S 
Sbjct: 189 PRPPTEGPRKSVSSASEHSTT------------EPSP---AARRRPSAGGGLQRPASRSL 233

Query: 73  DAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSP 132
            +    + +  + P   GPS    P   +  +      L A   P++    +     L P
Sbjct: 234 SS----SATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP 289

Query: 133 RAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPP-STPT-KTTYALLPA 190
            ++            SP  PP L      ++PSPP  P S  T    +PT + T++ LP+
Sbjct: 290 LSSSPLATPSPSAPPSPSAPPSL-----QTLPSPPATPPSQATTSLGSPTLQATHSFLPS 344

Query: 191 ------CGPHGDARDSEAELRDELLDSPPASP 216
                   P   A  + A    +   SPPASP
Sbjct: 345 PPLSPLATPPPQAPPALALPPLQAPPSPPASP 376



 Score = 34.3 bits (77), Expect = 0.94
 Identities = 74/262 (28%), Positives = 90/262 (34%), Gaps = 41/262 (15%)

Query: 31  ATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPG--GAPSAWADPGE 88
           ATT LG         T   +H  L   P  P A P P+     A P     PS  A P  
Sbjct: 326 ATTSLGSP-------TLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 378

Query: 89  GGPSPMLLPEGLSSQALST---EAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGG 145
              SP+  P   +  AL+    +AP      P +       QA  SP A+          
Sbjct: 379 ---SPLATPSPQAPNALAVHLLQAPFSPPPSPPV-------QAPFSPPASPPV-----SP 423

Query: 146 HASP--DPPPELCSQGDLSVPSPPPDPD---SFFTPPSTPTKTTYALLPACGPHGDARDS 200
            A+P    PP L +      PSPP  P    S   PP  P       L    P   A  +
Sbjct: 424 SATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA 483

Query: 201 EAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAP----AEGLDFPSGWGLSPQ 256
            A    + L SPPAS  G    +   S   SP  +    AP    A  L  P     SP 
Sbjct: 484 LATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPP----SPP 539

Query: 257 GSMVDERELHPAGTPEPPSSES 278
            S   +    P  TP P +S S
Sbjct: 540 ASPTLQAPRRPP-TPGPDTSVS 560


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.125    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,138,818
Number of Sequences: 37866
Number of extensions: 5120030
Number of successful extensions: 37699
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 151
Number of HSP's successfully gapped in prelim test: 1749
Number of HSP's that attempted gapping in prelim test: 21448
Number of HSP's gapped (non-prelim): 13241
length of query: 1522
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1407
effective length of database: 13,892,928
effective search space: 19547349696
effective search space used: 19547349696
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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