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Search of human proteins with 119392077
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5
[Homo sapiens]
(730 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 1460 0.0
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 565 e-161
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 565 e-161
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 379 e-105
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 379 e-105
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 379 e-105
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 350 3e-96
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 168 1e-41
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 160 5e-39
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 112 9e-25
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 112 2e-24
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 112 2e-24
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 110 4e-24
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 110 4e-24
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 110 4e-24
gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo... 89 1e-17
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 87 4e-17
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 86 9e-17
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 86 2e-16
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 81 3e-15
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 78 3e-14
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 77 7e-14
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 77 7e-14
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 73 1e-12
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 73 1e-12
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 73 1e-12
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 69 1e-11
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 60 5e-09
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 60 5e-09
gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchan... 60 9e-09
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 1460 bits (3779), Expect = 0.0
Identities = 730/730 (100%), Positives = 730/730 (100%)
Query: 1 MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQ 60
MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQ
Sbjct: 1 MAIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFEREEEWQNGVKLLLQ 60
Query: 61 LVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEEN 120
LVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEEN
Sbjct: 61 LVPLIPARGGICELSHQKIEDSEESSDEILVRLTSAVQRELAAVIALKARKSAIEQDEEN 120
Query: 121 NDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQ 180
NDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQ
Sbjct: 121 NDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQ 180
Query: 181 DDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHL 240
DDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHL
Sbjct: 181 DDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHL 240
Query: 241 EEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHL 300
EEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHL
Sbjct: 241 EEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHL 300
Query: 301 VSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDE 360
VSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDE
Sbjct: 301 VSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDE 360
Query: 361 YSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILK 420
YSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILK
Sbjct: 361 YSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKVSSIAQEILK 420
Query: 421 VVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAE 480
VVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAE
Sbjct: 421 VVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISKSLEASGRIYVYRKDLADTLNPFAE 480
Query: 481 NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL 540
NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL
Sbjct: 481 NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL 540
Query: 541 QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR 600
QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR
Sbjct: 541 QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR 600
Query: 601 LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG 660
LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG
Sbjct: 601 LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG 660
Query: 661 NKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALF 720
NKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALF
Sbjct: 661 NKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALF 720
Query: 721 ELSHRIEPRV 730
ELSHRIEPRV
Sbjct: 721 ELSHRIEPRV 730
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 565 bits (1456), Expect = e-161
Identities = 321/757 (42%), Positives = 469/757 (61%), Gaps = 34/757 (4%)
Query: 2 AIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFERE-----EEWQNGVK 56
A+G+WQ+LL+ G++ VDQ +FQD Y+FY+F DE E E EE Q+ +
Sbjct: 114 AVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTML 173
Query: 57 LLLQLVPLIPARGGICELSHQK-IEDSEESSDEIL-----VRLTSAVQRELAAVIALKAR 110
LL Q+ P R + + Q+ ++D E +E+L L++ V+RELA V+ ++
Sbjct: 174 LLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESH 233
Query: 111 KSA----IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK-------- 158
Q EE ++ + + +V GV+C L E D+ G++ LV
Sbjct: 234 AKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIV 293
Query: 159 LAKENYQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHW 218
L ++N FL+ DK++ + +D E TV++KE DQ VLVL+KV A G+++
Sbjct: 294 LREDNCHFLRVDKEDFNRIL-RDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQ 352
Query: 219 RYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSA 278
+Y V+SGTPEKILEH L + LE ++ T+++L+DF++ + VFM LC AL+ HY A
Sbjct: 353 KYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHA 412
Query: 279 KKYQGKE-ENSDVP-RRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEY 336
+ QG E E D KR+V+ LV QW A+Y D L ED+ S FL+ Y +V DD
Sbjct: 413 QPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMI 472
Query: 337 PILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCH 396
L+++L E +KI+ ++ + D +PQKK+K L QF+ + Q R + ++E+
Sbjct: 473 AALKEQLPELEKIV---KQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFK 529
Query: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456
VY +H+Y +++ V++ +E++ VA+K+ + E L +V ++ GEK L+PND+ +
Sbjct: 530 VYCMDHTYTTIRVPVATSVKEVISAVADKLG-SGEGLIIVKMSSGGEKVVLKPNDVSVFT 588
Query: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILG-MNTWDLALELMNFDWSLFNSIH 515
+L +GR++ ++ D+L P E E ++ M++ DLA ++ +DW LFN +H
Sbjct: 589 TLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVH 648
Query: 516 EQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAA 575
E ELIY TF R + TANL L L+R NE+Q WV TEI LCSQL KRVQL+KKFIKIAA
Sbjct: 649 ELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAA 708
Query: 576 HCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDA 635
HCK +NLNSFFAIVMGL+ +VSRL+ TWEK+P KFKK ++E ESL DPS NH+AYR
Sbjct: 709 HCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLT 768
Query: 636 FKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD- 694
K++PP IPFMPLL+KD+TF HEGNKTF+DNLVNFEK+ MIA+T RT+R+ R+ F
Sbjct: 769 VAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPD 828
Query: 695 --LSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
+ K HQ+++SYV L VID+Q+ L ++SHR+EPR
Sbjct: 829 AAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPR 865
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a
[Homo sapiens]
Length = 1011
Score = 565 bits (1456), Expect = e-161
Identities = 321/757 (42%), Positives = 469/757 (61%), Gaps = 34/757 (4%)
Query: 2 AIGVWQLLLDMGIMLSVDQHLYFQDTYVFYQFSSDECSYLYCEFERE-----EEWQNGVK 56
A+G+WQ+LL+ G++ VDQ +FQD Y+FY+F DE E E EE Q+ +
Sbjct: 258 AVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLPTEEEKKECDEELQDTML 317
Query: 57 LLLQLVPLIPARGGICELSHQK-IEDSEESSDEIL-----VRLTSAVQRELAAVIALKAR 110
LL Q+ P R + + Q+ ++D E +E+L L++ V+RELA V+ ++
Sbjct: 318 LLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESH 377
Query: 111 KSA----IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK-------- 158
Q EE ++ + + +V GV+C L E D+ G++ LV
Sbjct: 378 AKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIV 437
Query: 159 LAKENYQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKVQCCGPAPTAGSAESHW 218
L ++N FL+ DK++ + +D E TV++KE DQ VLVL+KV A G+++
Sbjct: 438 LREDNCHFLRVDKEDFNRIL-RDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQ 496
Query: 219 RYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSA 278
+Y V+SGTPEKILEH L + LE ++ T+++L+DF++ + VFM LC AL+ HY A
Sbjct: 497 KYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHA 556
Query: 279 KKYQGKE-ENSDVP-RRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEY 336
+ QG E E D KR+V+ LV QW A+Y D L ED+ S FL+ Y +V DD
Sbjct: 557 QPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMAFLEEFYVSVSDDARMI 616
Query: 337 PILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCH 396
L+++L E +KI+ ++ + D +PQKK+K L QF+ + Q R + ++E+
Sbjct: 617 AALKEQLPELEKIV---KQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFK 673
Query: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456
VY +H+Y +++ V++ +E++ VA+K+ + E L +V ++ GEK L+PND+ +
Sbjct: 674 VYCMDHTYTTIRVPVATSVKEVISAVADKLG-SGEGLIIVKMSSGGEKVVLKPNDVSVFT 732
Query: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILG-MNTWDLALELMNFDWSLFNSIH 515
+L +GR++ ++ D+L P E E ++ M++ DLA ++ +DW LFN +H
Sbjct: 733 TLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVH 792
Query: 516 EQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAA 575
E ELIY TF R + TANL L L+R NE+Q WV TEI LCSQL KRVQL+KKFIKIAA
Sbjct: 793 ELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAA 852
Query: 576 HCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDA 635
HCK +NLNSFFAIVMGL+ +VSRL+ TWEK+P KFKK ++E ESL DPS NH+AYR
Sbjct: 853 HCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLT 912
Query: 636 FKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD- 694
K++PP IPFMPLL+KD+TF HEGNKTF+DNLVNFEK+ MIA+T RT+R+ R+ F
Sbjct: 913 VAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPD 972
Query: 695 --LSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
+ K HQ+++SYV L VID+Q+ L ++SHR+EPR
Sbjct: 973 AAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPR 1009
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 379 bits (973), Expect = e-105
Identities = 269/781 (34%), Positives = 415/781 (53%), Gaps = 65/781 (8%)
Query: 3 IGVWQLLLDMGIMLSVDQHLYFQDTYV-FYQFSSDECSYLYCEFEREEEWQNGVKLLLQL 61
+G+ Q+LLD G + V FQD FY+F E + E EEE V LL Q
Sbjct: 111 VGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTH-EMEEELAEAVALLSQR 169
Query: 62 VPLIPARGGICELSHQKIEDSEESSDEILVR------LTSAVQRELAAVIALKARKSA-- 113
P + + Q+ ++ + E L+ L+++V+RELAAV+ + A
Sbjct: 170 GPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGT 229
Query: 114 --IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK--------LAKEN 163
Q ++ ++ + +V G++ L E D+ G++ LV L ++N
Sbjct: 230 VLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDN 289
Query: 164 YQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKV-QCCGPA--PTAGSAESHWRY 220
FL+ DK++ + +D E T++++E + VLVL++ Q GP+ PT G RY
Sbjct: 290 CHFLRVDKQDFNRII-KDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRN----RY 344
Query: 221 VVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKK 280
V+SGTPEKILE LL + + TET L DFLLT+ VFM + LC ALL H+ +
Sbjct: 345 TVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEP 404
Query: 281 YQGKEENSD--VPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPI 338
G E+ V +++++L LVSQW+ALY L D + FL+ + V D +
Sbjct: 405 AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNL 464
Query: 339 LEKELKEFQKILGMHR-RHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET-EEIFCH 396
L ++ E ++ HR + SPQ K + L ++ L + +++
Sbjct: 465 LREQWPERRRC---HRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYD 521
Query: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456
+ +HS ++++ V++ +E++ +A++ + + + LV + +G+ LQP+ ++
Sbjct: 522 ICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV-LVKVNSAGDAIGLQPDARGVAT 580
Query: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGM-NTWDLALELMNFDWSLFNSIH 515
SL + R++V L P + S L + + DLA +L + DWSLFNSIH
Sbjct: 581 SLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIH 640
Query: 516 EQELIYFTFSRQGSGE-HTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIA 574
+ ELI++ Q + TANL ++R NE+Q WVATE+ LC G R QL++KFIK+A
Sbjct: 641 QVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLA 700
Query: 575 AHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRD 634
AH K Q+NLNSFFA++ GL+ +++SRL+ TWE++P K +KL+S LE L DPS NH+ YR
Sbjct: 701 AHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRL 760
Query: 635 AFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD 694
A K+ PP IPFMPLLLKD+TFIHEGN T ++NL+NFEK+ M+A R L HCR++
Sbjct: 761 ALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVP 820
Query: 695 LSPKE------HQELK---------------------SYVNHLYVIDSQQALFELSHRIE 727
LSP H++ + +YV L VID+Q+ L LS +E
Sbjct: 821 LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 880
Query: 728 P 728
P
Sbjct: 881 P 881
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 379 bits (973), Expect = e-105
Identities = 269/781 (34%), Positives = 415/781 (53%), Gaps = 65/781 (8%)
Query: 3 IGVWQLLLDMGIMLSVDQHLYFQDTYV-FYQFSSDECSYLYCEFEREEEWQNGVKLLLQL 61
+G+ Q+LLD G + V FQD FY+F E + E EEE V LL Q
Sbjct: 111 VGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTH-EMEEELAEAVALLSQR 169
Query: 62 VPLIPARGGICELSHQKIEDSEESSDEILVR------LTSAVQRELAAVIALKARKSA-- 113
P + + Q+ ++ + E L+ L+++V+RELAAV+ + A
Sbjct: 170 GPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGT 229
Query: 114 --IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK--------LAKEN 163
Q ++ ++ + +V G++ L E D+ G++ LV L ++N
Sbjct: 230 VLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDN 289
Query: 164 YQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKV-QCCGPA--PTAGSAESHWRY 220
FL+ DK++ + +D E T++++E + VLVL++ Q GP+ PT G RY
Sbjct: 290 CHFLRVDKQDFNRII-KDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRN----RY 344
Query: 221 VVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKK 280
V+SGTPEKILE LL + + TET L DFLLT+ VFM + LC ALL H+ +
Sbjct: 345 TVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEP 404
Query: 281 YQGKEENSD--VPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPI 338
G E+ V +++++L LVSQW+ALY L D + FL+ + V D +
Sbjct: 405 AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNL 464
Query: 339 LEKELKEFQKILGMHR-RHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET-EEIFCH 396
L ++ E ++ HR + SPQ K + L ++ L + +++
Sbjct: 465 LREQWPERRRC---HRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYD 521
Query: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456
+ +HS ++++ V++ +E++ +A++ + + + LV + +G+ LQP+ ++
Sbjct: 522 ICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV-LVKVNSAGDAIGLQPDARGVAT 580
Query: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGM-NTWDLALELMNFDWSLFNSIH 515
SL + R++V L P + S L + + DLA +L + DWSLFNSIH
Sbjct: 581 SLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIH 640
Query: 516 EQELIYFTFSRQGSGE-HTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIA 574
+ ELI++ Q + TANL ++R NE+Q WVATE+ LC G R QL++KFIK+A
Sbjct: 641 QVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLA 700
Query: 575 AHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRD 634
AH K Q+NLNSFFA++ GL+ +++SRL+ TWE++P K +KL+S LE L DPS NH+ YR
Sbjct: 701 AHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRL 760
Query: 635 AFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD 694
A K+ PP IPFMPLLLKD+TFIHEGN T ++NL+NFEK+ M+A R L HCR++
Sbjct: 761 ALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVP 820
Query: 695 LSPKE------HQELK---------------------SYVNHLYVIDSQQALFELSHRIE 727
LSP H++ + +YV L VID+Q+ L LS +E
Sbjct: 821 LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 880
Query: 728 P 728
P
Sbjct: 881 P 881
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 379 bits (973), Expect = e-105
Identities = 269/781 (34%), Positives = 415/781 (53%), Gaps = 65/781 (8%)
Query: 3 IGVWQLLLDMGIMLSVDQHLYFQDTYV-FYQFSSDECSYLYCEFEREEEWQNGVKLLLQL 61
+G+ Q+LLD G + V FQD FY+F E + E EEE V LL Q
Sbjct: 153 VGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVGTH-EMEEELAEAVALLSQR 211
Query: 62 VPLIPARGGICELSHQKIEDSEESSDEILVR------LTSAVQRELAAVIALKARKSA-- 113
P + + Q+ ++ + E L+ L+++V+RELAAV+ + A
Sbjct: 212 GPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGT 271
Query: 114 --IEQDEENNDKHVAVTEAESVPDSQAGVMCKLQERDEIGRIELVQK--------LAKEN 163
Q ++ ++ + +V G++ L E D+ G++ LV L ++N
Sbjct: 272 VLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDN 331
Query: 164 YQFLQTDKKEQEKSEHQDDEVTTVQVKEQDQSVLVLKKV-QCCGPA--PTAGSAESHWRY 220
FL+ DK++ + +D E T++++E + VLVL++ Q GP+ PT G RY
Sbjct: 332 CHFLRVDKQDFNRII-KDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRN----RY 386
Query: 221 VVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKK 280
V+SGTPEKILE LL + + TET L DFLLT+ VFM + LC ALL H+ +
Sbjct: 387 TVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEP 446
Query: 281 YQGKEENSD--VPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPI 338
G E+ V +++++L LVSQW+ALY L D + FL+ + V D +
Sbjct: 447 AGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNL 506
Query: 339 LEKELKEFQKILGMHR-RHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET-EEIFCH 396
L ++ E ++ HR + SPQ K + L ++ L + +++
Sbjct: 507 LREQWPERRRC---HRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYD 563
Query: 397 VYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPNDLVISK 456
+ +HS ++++ V++ +E++ +A++ + + + LV + +G+ LQP+ ++
Sbjct: 564 ICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQV-LVKVNSAGDAIGLQPDARGVAT 622
Query: 457 SLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGM-NTWDLALELMNFDWSLFNSIH 515
SL + R++V L P + S L + + DLA +L + DWSLFNSIH
Sbjct: 623 SLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIH 682
Query: 516 EQELIYFTFSRQGSGE-HTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIA 574
+ ELI++ Q + TANL ++R NE+Q WVATE+ LC G R QL++KFIK+A
Sbjct: 683 QVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLA 742
Query: 575 AHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRD 634
AH K Q+NLNSFFA++ GL+ +++SRL+ TWE++P K +KL+S LE L DPS NH+ YR
Sbjct: 743 AHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRL 802
Query: 635 AFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGD 694
A K+ PP IPFMPLLLKD+TFIHEGN T ++NL+NFEK+ M+A R L HCR++
Sbjct: 803 ALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVP 862
Query: 695 LSPKE------HQELK---------------------SYVNHLYVIDSQQALFELSHRIE 727
LSP H++ + +YV L VID+Q+ L LS +E
Sbjct: 863 LSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELE 922
Query: 728 P 728
P
Sbjct: 923 P 923
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 350 bits (898), Expect = 3e-96
Identities = 191/445 (42%), Positives = 275/445 (61%), Gaps = 11/445 (2%)
Query: 293 RKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVLDDVYEYPILEKE-LKEFQKILG 351
RK+ L ++ ++ Y+ L E+E + +K +Y ++ D Y L ++ L+ Q +
Sbjct: 9 RKQACLAMLLHFLDTYQGLLQEEEGAGHIIKDLYLLIMKDESLYQGLREDTLRLHQLVET 68
Query: 352 MHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTETEEIFCHVYITEHSYVSVKAKV 411
+ + + P K+ K LF F ++ LQ R ++EIFC VY+ +HSYV++++++
Sbjct: 69 VELKIPEENQPPSKQVKPLFRHFRRIDSCLQTRVAFRGSDEIFCRVYMPDHSYVTIRSRL 128
Query: 412 SSIAQEILKVVAEKIQYAEE------DLALVAITFSGEKHELQPNDLVISKSLEASGRIY 465
S+ Q+IL V EK+QY+EE L LVA++ SGEK LQP + + +L + ++
Sbjct: 129 SASVQDILGSVTEKLQYSEEPAGREDSLILVAVSSSGEKVLLQPTEDCVFTALGINSHLF 188
Query: 466 VYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFS 525
+D + L P E + I + D+A L F W LF +HE E + + F
Sbjct: 189 ACTRDSYEALVPLPEEIQVSPGDTEIHRVEPEDVANHLTAFHWELFRCVHELEFVDYVFH 248
Query: 526 RQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNS 585
+ TANL LLLQRC+EV WVATE+LLC GKR QL+KKFIKIAA CK ++L S
Sbjct: 249 GERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLS 308
Query: 586 FFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIP 645
F+A+VMGL+ A+VSRL TWEK+PGKFK LF + E+LTDP NHK+YR+ KMKPP IP
Sbjct: 309 FYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFENLTDPCRNHKSYREVISKMKPPVIP 368
Query: 646 FMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQF---GDLSPKEHQE 702
F+PL+LKD+TF+HEG+KT +D LVN EKLH +A+ VRT+R R+ + SP H +
Sbjct: 369 FVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASP-NHLQ 427
Query: 703 LKSYVNHLYVIDSQQALFELSHRIE 727
K+YV VID+Q LFELS+++E
Sbjct: 428 TKAYVRQFQVIDNQNLLFELSYKLE 452
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 168 bits (426), Expect = 1e-41
Identities = 105/267 (39%), Positives = 157/267 (58%), Gaps = 9/267 (3%)
Query: 421 VVAEKIQYAEEDLALVAITFSGE-KHELQPNDLV-ISKSLEASGRIYVYRKDLADTLNPF 478
V A QY+ L V++T G K P+ L ++ ++ SGR Y+ +TL
Sbjct: 643 VTATPDQYS---LCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSD 699
Query: 479 AENEESQQRS-MRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLS 537
+ +E + S + +L ++T ++A +L ++ LF +I E I F + S ANL
Sbjct: 700 EDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLR-SKTSCANLK 758
Query: 538 LLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTAS 597
+ N+ WVA+EIL + KR++++K FIKIA HC+ +N NS FAI+ GLN A
Sbjct: 759 RFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAP 818
Query: 598 VSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAF--KKMKPPKIPFMPLLLKDVT 655
V+RL TWEK+P K++KLF +L+ L DPS N YR+ + ++PP IP P++ KD+T
Sbjct: 819 VARLRTTWEKLPNKYEKLFQDLQDLFDPSRNMAKYRNVLNSQNLQPPIIPLFPVIKKDLT 878
Query: 656 FIHEGNKTFLDNLVNFEKLHMIADTVR 682
F+HEGN + +D LVNFEKL MIA +R
Sbjct: 879 FLHEGNDSKVDGLVNFEKLRMIAKEIR 905
Score = 41.2 bits (95), Expect = 0.003
Identities = 53/260 (20%), Positives = 106/260 (40%), Gaps = 60/260 (23%)
Query: 93 LTSAVQRELAAVIAL----KARKSAIEQDEENNDKHVAVTEAESV--PDSQAGVMC---- 142
+T +V+REL AV+ +A + EE + V + + V PD +A ++C
Sbjct: 139 MTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNS 198
Query: 143 ------------KLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVK 190
K R ++ + V ++ + L +K +K E + + V + +
Sbjct: 199 FGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHR 258
Query: 191 EQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETET 250
E D++ G+ + H +V+ GT E++ HL+ + + + T
Sbjct: 259 ELDRT----------------GTRKGH---IVIKGTSERLTMHLVEEHSVVD------PT 293
Query: 251 LLDDFLLTYTVFMTTD-DLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYK 309
++DFLLTY F+++ ++ + LL ++ P + KV +V W+ +
Sbjct: 294 FIEDFLLTYRTFLSSPMEVGKKLLEWFND------------PSLRDKVTRVVLLWVNNHF 341
Query: 310 DWLPEDEHSKMFLKTIYRNV 329
+ D FL+ N+
Sbjct: 342 NDFEGDPAMTRFLEEFENNL 361
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 160 bits (404), Expect = 5e-39
Identities = 90/232 (38%), Positives = 140/232 (60%), Gaps = 4/232 (1%)
Query: 454 ISKSLEASGRIYVYRKDLADTLNPFAENEESQQRS-MRILGMNTWDLALELMNFDWSLFN 512
++ ++ +GR Y+ +TL + +E + S + +L ++T ++A +L D+ LF
Sbjct: 818 LADRIQLNGRYYLKNNMETETLCSDEDAQELVKESQLSMLQLSTIEVATQLSMRDFDLFR 877
Query: 513 SIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIK 572
+I E I F +T +L N+ WVA+EIL + KR++++K FIK
Sbjct: 878 NIEPTEYIDDLFKLNSKTGNT-HLKRFEDIVNQETFWVASEILTEANQLKRMKIIKHFIK 936
Query: 573 IAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAY 632
IA HC+ +N NS FAI+ GLN ASV+RL TWEK+P K++K +L+ + DPS N Y
Sbjct: 937 IALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLPSKYEKHLQDLQDIFDPSRNMAKY 996
Query: 633 RD--AFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVR 682
R+ + + M+PP IP P++ KD+TF+HEGN + +D LVNFEKL MI+ +R
Sbjct: 997 RNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMISKEIR 1048
Score = 39.3 bits (90), Expect = 0.013
Identities = 54/262 (20%), Positives = 108/262 (41%), Gaps = 60/262 (22%)
Query: 93 LTSAVQRELAAVIALKARKSA----IEQDEENNDKHVAV--TEAESVPDSQA-------- 138
+T +V+REL +V+ + + A +E +E + +V + T S PD +
Sbjct: 284 MTMSVRRELCSVMIFEVVEQAGAIILEDGQELDSWYVILNGTVEISHPDGKVENLFMGNS 343
Query: 139 -GVMCKLQE-------RDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVK 190
G+ L + R ++ + V ++ ++ L +K K E + + V + +
Sbjct: 344 FGITPTLDKQYMHGIVRTKVDDCQFVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHR 403
Query: 191 EQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETET 250
E D+S G+ + H +V+ TPE+++ HL+ + + + T
Sbjct: 404 ELDRS----------------GTRKGH---IVIKATPERLIMHLIEEHSIVD------PT 438
Query: 251 LLDDFLLTYTVFMTTD-DLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYK 309
++DFLLTY F+ + D+ LL + + + KV +V W+ +
Sbjct: 439 YIEDFLLTYRTFLESPLDVGIKLLEWFK------------IDSLRDKVTRIVLLWVNNHF 486
Query: 310 DWLPEDEHSKMFLKTIYRNVLD 331
+ D FL+ +N+ D
Sbjct: 487 NDFEGDPAMTRFLEEFEKNLED 508
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 112 bits (281), Expect = 9e-25
Identities = 67/239 (28%), Positives = 118/239 (49%), Gaps = 6/239 (2%)
Query: 494 MNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATE 553
++ +LA ++ D +F SI +E + + + E T + Q N++ VA++
Sbjct: 1001 LSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQ 1060
Query: 554 ILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFK 613
I+ + + R ++K++ +A C+ N N I LN +++ RL +TW K+ + K
Sbjct: 1061 IMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTK 1120
Query: 614 KLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFE 672
L +L+ K R+ K PP +P++ + L D+ FI EG F + LVNF
Sbjct: 1121 ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFS 1180
Query: 673 KLHMIADTVRTLRHCRTNQFG-DLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV 730
K+ MI+ +R +R + + D PK Q Y+ +I + L+ELS +IEPR+
Sbjct: 1181 KMRMISHIIREIRQFQQTSYRIDHQPKVAQ----YLLDKDLIIDEDTLYELSLKIEPRL 1235
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 112 bits (279), Expect = 2e-24
Identities = 71/232 (30%), Positives = 131/232 (56%), Gaps = 10/232 (4%)
Query: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
++A +L D LF I E++ + +++ + E + NL+ + N + WV + I+L
Sbjct: 861 EIAEQLTLLDAELFYKIEIPEVLLW--AKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 918
Query: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
+ R +L+ KFIKI H + N NS+ AI+ L++A + RL W+K + + +
Sbjct: 919 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLA 973
Query: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMI 677
E +L D S + +AYR A +++PP IP++ L+L+D+TF+H GN ++D VNF K
Sbjct: 974 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1033
Query: 678 ADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
+ + ++R C D+ + + ++ ++ N +++AL+ELS +I+PR
Sbjct: 1034 FNILDSMR-CFQQAHYDM--RRNDDIINFFNDFSDHLAEEALWELSLKIKPR 1082
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 112 bits (279), Expect = 2e-24
Identities = 71/232 (30%), Positives = 131/232 (56%), Gaps = 10/232 (4%)
Query: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
++A +L D LF I E++ + +++ + E + NL+ + N + WV + I+L
Sbjct: 843 EIAEQLTLLDAELFYKIEIPEVLLW--AKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQ 900
Query: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
+ R +L+ KFIKI H + N NS+ AI+ L++A + RL W+K + + +
Sbjct: 901 EKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE--WQK---QTSEGLA 955
Query: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMI 677
E +L D S + +AYR A +++PP IP++ L+L+D+TF+H GN ++D VNF K
Sbjct: 956 EYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYIDGKVNFSKRWQQ 1015
Query: 678 ADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
+ + ++R C D+ + + ++ ++ N +++AL+ELS +I+PR
Sbjct: 1016 FNILDSMR-CFQQAHYDM--RRNDDIINFFNDFSDHLAEEALWELSLKIKPR 1064
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 110 bits (276), Expect = 4e-24
Identities = 67/236 (28%), Positives = 120/236 (50%), Gaps = 8/236 (3%)
Query: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
++A +L D +F I +E + + E T + + N++ +A+EI+
Sbjct: 1025 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1084
Query: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
+ RV ++K++ +A C+ N N+ I +N +++ RL +TW K+ + K L
Sbjct: 1085 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1144
Query: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHM 676
+L+ L K R+A K PP +P++ + L D+ FI EG + D LVNF K+ M
Sbjct: 1145 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1204
Query: 677 IADTVRTLRHCRTNQFGDLSPK-EHQ-ELKSYVNHLYVIDSQQALFELSHRIEPRV 730
I+ +R +R QF + K EHQ ++ Y+ + +++L+E S RIEP++
Sbjct: 1205 ISHIIREIR-----QFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 1255
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 110 bits (276), Expect = 4e-24
Identities = 67/236 (28%), Positives = 120/236 (50%), Gaps = 8/236 (3%)
Query: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
++A +L D +F I +E + + E T + + N++ +A+EI+
Sbjct: 1041 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 1100
Query: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
+ RV ++K++ +A C+ N N+ I +N +++ RL +TW K+ + K L
Sbjct: 1101 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 1160
Query: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHM 676
+L+ L K R+A K PP +P++ + L D+ FI EG + D LVNF K+ M
Sbjct: 1161 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 1220
Query: 677 IADTVRTLRHCRTNQFGDLSPK-EHQ-ELKSYVNHLYVIDSQQALFELSHRIEPRV 730
I+ +R +R QF + K EHQ ++ Y+ + +++L+E S RIEP++
Sbjct: 1221 ISHIIREIR-----QFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 1271
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 110 bits (276), Expect = 4e-24
Identities = 67/236 (28%), Positives = 120/236 (50%), Gaps = 8/236 (3%)
Query: 498 DLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLC 557
++A +L D +F I +E + + E T + + N++ +A+EI+
Sbjct: 257 EIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRN 316
Query: 558 SQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFS 617
+ RV ++K++ +A C+ N N+ I +N +++ RL +TW K+ + K L
Sbjct: 317 EDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALID 376
Query: 618 ELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHM 676
+L+ L K R+A K PP +P++ + L D+ FI EG + D LVNF K+ M
Sbjct: 377 KLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRM 436
Query: 677 IADTVRTLRHCRTNQFGDLSPK-EHQ-ELKSYVNHLYVIDSQQALFELSHRIEPRV 730
I+ +R +R QF + K EHQ ++ Y+ + +++L+E S RIEP++
Sbjct: 437 ISHIIREIR-----QFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKL 487
>gi|32441283 Ral GEF with PH domain and SH3 binding motif 2 [Homo
sapiens]
Length = 583
Score = 89.4 bits (220), Expect = 1e-17
Identities = 63/244 (25%), Positives = 116/244 (47%), Gaps = 8/244 (3%)
Query: 491 ILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWV 550
+L + + A ++ D +F +I EL ++++ N +R N V WV
Sbjct: 45 VLKVTPEEYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWV 104
Query: 551 ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610
EIL L R +++ +IK A NL++ A+V GL +A + RL++TW +
Sbjct: 105 VREILHAQTLKIRAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSR 164
Query: 611 KFKKLFSELESLTDPSLNHKAYRDAFKKMK-PPKIPFMPLLLKDVTFIHEGNKTFLDNLV 669
K K F +LE + N+K RD +K P IP++ + L D+T+I + L
Sbjct: 165 KDKTTFEKLEYVMSKEDNYKRLRDYISSLKMTPCIPYLGIYLSDLTYIDSAYPSTGSILE 224
Query: 670 NFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELSH 724
N ++ +++ + +R + + + D+ H ++ Y+N + I+ Q ++LS
Sbjct: 225 NEQRSNLMNNILRIISDLQQSCEYDIPMLPH--VQKYLNSVQYIEELQKFVEDDNYKLSL 282
Query: 725 RIEP 728
+IEP
Sbjct: 283 KIEP 286
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 87.4 bits (215), Expect = 4e-17
Identities = 61/245 (24%), Positives = 117/245 (47%), Gaps = 9/245 (3%)
Query: 491 ILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWV 550
+L + + A ++ D +F +I +EL +S++ N+ +R N+V WV
Sbjct: 46 VLKVTPEEFASQITLMDIPVFKAIQPEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWV 105
Query: 551 ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610
EIL L R +++ F+KIA NL+S ++V L +A + RL++TW +
Sbjct: 106 VREILTAQTLKIRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNR 165
Query: 611 KFKKLFSELESLTDPSLNHKAYRDAFKKMK-PPKIPFMPLLLKDVTFIHEGNKTFLDNLV 669
K K F +L+ L N+K R+ + +K P IP++ + L D+ +I +
Sbjct: 166 KDKTTFEKLDYLMSKEDNYKRTREYIRSLKMVPSIPYLGIYLLDLIYIDSAYPASGSIME 225
Query: 670 NFEKLHMIADTVRTLRHCRTN-QFGDLSPKEHQELKSYVNHLYVIDSQQAL-----FELS 723
N ++ + + + +R + + + + L+ H ++ Y+ + I+ Q ++LS
Sbjct: 226 NEQRSNQMNNILRIIADLQVSCSYDHLTTLPH--VQKYLKSVRYIEELQKFVEDDNYKLS 283
Query: 724 HRIEP 728
RIEP
Sbjct: 284 LRIEP 288
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 86.3 bits (212), Expect = 9e-17
Identities = 70/230 (30%), Positives = 104/230 (45%), Gaps = 24/230 (10%)
Query: 473 DTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQ----- 527
D L +S QR + + + + LA +L + + N I +E + +
Sbjct: 183 DRLTVLKTKPQSIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDND 242
Query: 528 ----GSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNL 583
+ T NL ++ N + VATEI + + R ++++ FI +A C N
Sbjct: 243 KSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNF 302
Query: 584 NSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFK------ 637
NS AI+ G+N + VSRL +TW K+ K K F LE DPS N YR A +
Sbjct: 303 NSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQRS 359
Query: 638 -----KMKPPKIPFMPLLLKDVTFIHEGNKTFLDN-LVNFEKLHMIADTV 681
+ IPF LL+KD+ F++EG L N VNFEK +A V
Sbjct: 360 LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQV 409
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 85.5 bits (210), Expect = 2e-16
Identities = 57/249 (22%), Positives = 116/249 (46%), Gaps = 15/249 (6%)
Query: 491 ILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWV 550
+L ++ ++A +L + L+ ++ EL+ ++++ ++ NL +++ + LW
Sbjct: 776 LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWF 835
Query: 551 ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610
I+ L +RV +V + I+I + N N +V +N++ V RL T+E+IP
Sbjct: 836 EKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPS 895
Query: 611 KFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL----D 666
+ KK+ E L++ ++K Y + + PP +PF + L ++ EGN L
Sbjct: 896 RQKKILEEAHELSED--HYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGK 953
Query: 667 NLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQA------LF 720
L+NF K +A+ ++ + + + ++K + +L + + LF
Sbjct: 954 ELINFSKRRKVAEITGEIQQYQNQPY---CLRVESDIKRFFENLNPMGNSMEKEFTDYLF 1010
Query: 721 ELSHRIEPR 729
S IEPR
Sbjct: 1011 NKSLEIEPR 1019
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 81.3 bits (199), Expect = 3e-15
Identities = 58/163 (35%), Positives = 85/163 (52%), Gaps = 15/163 (9%)
Query: 531 EHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIV 590
+ T+NL ++ N + VATEI + ++ +R Q+++ FI +A C N NS AI+
Sbjct: 243 DKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAII 302
Query: 591 MGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFK-----------KM 639
G+N + VSRL +TW K+ + K F LE DP+ N YR A +
Sbjct: 303 SGMNMSPVSRLKKTWAKV--RTAKFFI-LEHQMDPTGNFCNYRTALRGAAHRSLTAHSSR 359
Query: 640 KPPKIPFMPLLLKDVTFIHEGNKTFLDN-LVNFEKLHMIADTV 681
+ IPF LL+KD+ F++EG L N VNFEK +A V
Sbjct: 360 EKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQV 402
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 78.2 bits (191), Expect = 3e-14
Identities = 58/265 (21%), Positives = 115/265 (43%), Gaps = 27/265 (10%)
Query: 481 NEESQQRSMRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLL 540
++ Q + ++ ++ ++A +L + L+ + EL+ ++++ ++ NL ++
Sbjct: 764 SKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMI 823
Query: 541 QRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSR 600
+ + LW I+ +RV ++ + I+I + N N IV +N+ SV R
Sbjct: 824 RHTTNLTLWFEKCIVEAENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYR 883
Query: 601 LSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEG 660
L T+E + + +K+ E L+ + K Y K + PP +PF + L ++ EG
Sbjct: 884 LDHTFEALQERKRKILDEAVELSQD--HFKKYLVKLKSINPPCVPFFGIYLTNILKTEEG 941
Query: 661 NKTFL----DNLVNFEKLHMIADTVRTLRHCRTNQ------------FGDLSPKEHQELK 704
N FL +L+NF K +A+ ++ + F +L+P K
Sbjct: 942 NNDFLKKKGKDLINFSKRRKVAEITGEIQQYQNQPYCLRIEPDMRRFFENLNPMGSASEK 1001
Query: 705 SYVNHLYVIDSQQALFELSHRIEPR 729
+ ++ LF S IEPR
Sbjct: 1002 EFTDY---------LFNKSLEIEPR 1017
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 76.6 bits (187), Expect = 7e-14
Identities = 71/291 (24%), Positives = 131/291 (45%), Gaps = 21/291 (7%)
Query: 451 DLVISKSLEASGRIY----VYRKDLADTLNPFAENEESQQRSMRIL--GMNTWDLALELM 504
+LV +K E R+ + +D + L ++ S++R + +L + +L+ L
Sbjct: 155 ELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLT 214
Query: 505 NFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRV 564
++ F I + + + T S+ L CN + WV +L R
Sbjct: 215 YLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIAL--CNGISQWVQLMVLSRPTPQLRA 272
Query: 565 QLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTD 624
++ KFI++A +N N+ A++ GL +S+SRL +T +P + K+ E+ L
Sbjct: 273 EVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLS 332
Query: 625 PSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHMIADTVRT 683
S N+ YR A+ + KIP + + LKD+ ++E +L D VN KL + + +
Sbjct: 333 SSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISE 392
Query: 684 LRHCRTNQFGDLSPKEHQELKSYVNHLYVID-----SQQALFELSHRIEPR 729
L Q +++P E + HL + ++ ++ELS+ EPR
Sbjct: 393 L-----VQLQEVAPP--LEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 76.6 bits (187), Expect = 7e-14
Identities = 71/291 (24%), Positives = 131/291 (45%), Gaps = 21/291 (7%)
Query: 451 DLVISKSLEASGRIY----VYRKDLADTLNPFAENEESQQRSMRIL--GMNTWDLALELM 504
+LV +K E R+ + +D + L ++ S++R + +L + +L+ L
Sbjct: 155 ELVKAKGEELHCRLIDTTQINARDWSRKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLT 214
Query: 505 NFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRV 564
++ F I + + + T S+ L CN + WV +L R
Sbjct: 215 YLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIAL--CNGISQWVQLMVLSRPTPQLRA 272
Query: 565 QLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTD 624
++ KFI++A +N N+ A++ GL +S+SRL +T +P + K+ E+ L
Sbjct: 273 EVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLS 332
Query: 625 PSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHMIADTVRT 683
S N+ YR A+ + KIP + + LKD+ ++E +L D VN KL + + +
Sbjct: 333 SSRNYDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISE 392
Query: 684 LRHCRTNQFGDLSPKEHQELKSYVNHLYVID-----SQQALFELSHRIEPR 729
L Q +++P E + HL + ++ ++ELS+ EPR
Sbjct: 393 L-----VQLQEVAPP--LEANKDLVHLLTLSLDLYYTEDEIYELSYAREPR 436
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 72.8 bits (177), Expect = 1e-12
Identities = 56/211 (26%), Positives = 103/211 (48%), Gaps = 5/211 (2%)
Query: 521 YFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQ 580
Y ++ G E+ L + N + WV +L +R +++ KFI +A
Sbjct: 176 YQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQL 235
Query: 581 RNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMK 640
+N N+ A+V GL+ +S+SRL +T + + K ++E+ L + N+ YR AF
Sbjct: 236 KNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCD 295
Query: 641 PPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKE 699
KIP + + LKD+ +H + +N VN K+H ++ T+ L + N L P
Sbjct: 296 GFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQ-NASHHLEP-- 352
Query: 700 HQELKSYVN-HLYVIDSQQALFELSHRIEPR 729
+ +L + + L + ++ +++LS +EPR
Sbjct: 353 NMDLINLLTLSLDLYHTEDDIYKLSLVLEPR 383
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 72.8 bits (177), Expect = 1e-12
Identities = 56/211 (26%), Positives = 103/211 (48%), Gaps = 5/211 (2%)
Query: 521 YFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQ 580
Y ++ G E+ L + N + WV +L +R +++ KFI +A
Sbjct: 176 YQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQL 235
Query: 581 RNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMK 640
+N N+ A+V GL+ +S+SRL +T + + K ++E+ L + N+ YR AF
Sbjct: 236 KNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCD 295
Query: 641 PPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKE 699
KIP + + LKD+ +H + +N VN K+H ++ T+ L + N L P
Sbjct: 296 GFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQ-NASHHLEP-- 352
Query: 700 HQELKSYVN-HLYVIDSQQALFELSHRIEPR 729
+ +L + + L + ++ +++LS +EPR
Sbjct: 353 NMDLINLLTLSLDLYHTEDDIYKLSLVLEPR 383
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 72.8 bits (177), Expect = 1e-12
Identities = 56/211 (26%), Positives = 103/211 (48%), Gaps = 5/211 (2%)
Query: 521 YFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQ 580
Y ++ G E+ L + N + WV +L +R +++ KFI +A
Sbjct: 176 YQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQL 235
Query: 581 RNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMK 640
+N N+ A+V GL+ +S+SRL +T + + K ++E+ L + N+ YR AF
Sbjct: 236 KNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAFADCD 295
Query: 641 PPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFEKLHMIADTVRTLRHCRTNQFGDLSPKE 699
KIP + + LKD+ +H + +N VN K+H ++ T+ L + N L P
Sbjct: 296 GFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQ-NASHHLEP-- 352
Query: 700 HQELKSYVN-HLYVIDSQQALFELSHRIEPR 729
+ +L + + L + ++ +++LS +EPR
Sbjct: 353 NMDLINLLTLSLDLYHTEDDIYKLSLVLEPR 383
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 69.3 bits (168), Expect = 1e-11
Identities = 68/249 (27%), Positives = 113/249 (45%), Gaps = 27/249 (10%)
Query: 499 LALELMNFDWSLFNSIHEQELIYFTFSRQGSGEH--------TANLSLLLQRCNEVQLWV 550
LA +L + + +SI+ ++L+ H T +L N + + V
Sbjct: 218 LAQQLTHIELDRVSSIYPEDLMQIVSHMDSLDNHRCRGDLTKTYSLEAYDNWFNCLSMLV 277
Query: 551 ATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPG 610
ATE+ + R ++++ FI +A C N NS AI+ G+N + V+RL +TW K+
Sbjct: 278 ATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKV-- 335
Query: 611 KFKKLFSELESLTDPSLNHKAYRDAFK-----------KMKPPKIPFMPLLLKDVTFIHE 659
K K F LE DPS N YR A + + IP L +KD+ F+H+
Sbjct: 336 KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHK 394
Query: 660 GNKTFLDN-LVNFEKLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQA 718
+ L N +NF+K I+ R + T + ++ ++++SY+ I S++A
Sbjct: 395 IHTNHLPNGHINFKKFWEIS---RQIHEFMTWTQVECPFEKDKKIQSYL-LTAPIYSEEA 450
Query: 719 LFELSHRIE 727
LF S E
Sbjct: 451 LFVASFESE 459
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 60.5 bits (145), Expect = 5e-09
Identities = 60/237 (25%), Positives = 102/237 (43%), Gaps = 5/237 (2%)
Query: 494 MNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATE 553
+ T +LA L ++ F +I Q+L + QGS L + N V WV
Sbjct: 200 LETGELAQHLTYLEFRSFQAITPQDLRSYVL--QGSVRGCPALEGSVGLSNSVSRWVQVM 257
Query: 554 ILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFK 613
+L +R Q++ KFI +A +N N+ A+ GL +++SRL + +
Sbjct: 258 VLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 317
Query: 614 KLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFE 672
K EL L N+ YR + ++P + + LKD+ +HE L D ++
Sbjct: 318 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 377
Query: 673 KLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
KL+ + ++ L + Q S E L L + ++ ++ELS+ EPR
Sbjct: 378 KLNNLYLRLQELVALQ-GQHPPCSANE-DLLHLLTLSLDLFYTEDEIYELSYAREPR 432
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 60.5 bits (145), Expect = 5e-09
Identities = 60/237 (25%), Positives = 102/237 (43%), Gaps = 5/237 (2%)
Query: 494 MNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATE 553
+ T +LA L ++ F +I Q+L + QGS L + N V WV
Sbjct: 186 LETGELAQHLTYLEFRSFQAITPQDLRSYVL--QGSVRGCPALEGSVGLSNSVSRWVQVM 243
Query: 554 ILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFK 613
+L +R Q++ KFI +A +N N+ A+ GL +++SRL + +
Sbjct: 244 VLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDST 303
Query: 614 KLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFL-DNLVNFE 672
K EL L N+ YR + ++P + + LKD+ +HE L D ++
Sbjct: 304 KALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLP 363
Query: 673 KLHMIADTVRTLRHCRTNQFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPR 729
KL+ + ++ L + Q S E L L + ++ ++ELS+ EPR
Sbjct: 364 KLNNLYLRLQELVALQ-GQHPPCSANE-DLLHLLTLSLDLFYTEDEIYELSYAREPR 418
>gi|239752520 PREDICTED: similar to Rap guanine nucleotide exchange
factor 2, partial [Homo sapiens]
Length = 803
Score = 59.7 bits (143), Expect = 9e-09
Identities = 51/165 (30%), Positives = 85/165 (51%), Gaps = 7/165 (4%)
Query: 421 VVAEKIQYAEEDLALVAITFSGE-KHELQPNDLV-ISKSLEASGRIYVYRKDLADTLNPF 478
V A QY+ L V++T G K P+ L ++ ++ SGR Y+ +TL
Sbjct: 643 VTATPDQYS---LCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSD 699
Query: 479 AENEESQQRS-MRILGMNTWDLALELMNFDWSLFNSIHEQELIYFTFSRQGSGEHTANLS 537
+ +E + S + +L ++T ++A +L ++ LF +I E I F + S ANL
Sbjct: 700 EDAQELLRESQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLR-SKTSCANLK 758
Query: 538 LLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRN 582
+ N+ WVA+EIL + KR++++K FIKIA HC+ +N
Sbjct: 759 RFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKN 803
Score = 41.2 bits (95), Expect = 0.003
Identities = 53/260 (20%), Positives = 106/260 (40%), Gaps = 60/260 (23%)
Query: 93 LTSAVQRELAAVIAL----KARKSAIEQDEENNDKHVAVTEAESV--PDSQAGVMC---- 142
+T +V+REL AV+ +A + EE + V + + V PD +A ++C
Sbjct: 139 MTMSVRRELCAVMVFAVVERAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNS 198
Query: 143 ------------KLQERDEIGRIELVQKLAKENYQFLQTDKKEQEKSEHQDDEVTTVQVK 190
K R ++ + V ++ + L +K +K E + + V + +
Sbjct: 199 FGVSPTMDKEYMKGVMRTKVDDCQFVCIAQQDYCRILNQVEKNMQKVEEEGEIVMVKEHR 258
Query: 191 EQDQSVLVLKKVQCCGPAPTAGSAESHWRYVVVSGTPEKILEHLLNDLHLEEVQDKETET 250
E D++ G+ + H +V+ GT E++ HL+ + + + T
Sbjct: 259 ELDRT----------------GTRKGH---IVIKGTSERLTMHLVEEHSVVD------PT 293
Query: 251 LLDDFLLTYTVFMTTD-DLCQALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYK 309
++DFLLTY F+++ ++ + LL ++ P + KV +V W+ +
Sbjct: 294 FIEDFLLTYRTFLSSPMEVGKKLLEWFND------------PSLRDKVTRVVLLWVNNHF 341
Query: 310 DWLPEDEHSKMFLKTIYRNV 329
+ D FL+ N+
Sbjct: 342 NDFEGDPAMTRFLEEFENNL 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,578,524
Number of Sequences: 37866
Number of extensions: 1184547
Number of successful extensions: 4317
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 87
Number of HSP's that attempted gapping in prelim test: 4114
Number of HSP's gapped (non-prelim): 240
length of query: 730
length of database: 18,247,518
effective HSP length: 110
effective length of query: 620
effective length of database: 14,082,258
effective search space: 8730999960
effective search space used: 8730999960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.