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Search of human proteins with 118766328
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118766328 transmembrane and tetratricopeptide repeat
containing 4 isoform 2 [Homo sapiens]
(741 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118766328 transmembrane and tetratricopeptide repeat containi... 1496 0.0
gi|118766330 transmembrane and tetratricopeptide repeat containi... 1496 0.0
gi|224809432 transmembrane and tetratricopeptide repeat containi... 392 e-109
gi|22749211 transmembrane and tetratricopeptide repeat containin... 377 e-104
gi|83415184 transmembrane and tetratricopeptide repeat containin... 307 3e-83
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 113 6e-25
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 113 6e-25
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 71 3e-12
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 71 3e-12
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 71 3e-12
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 58 4e-08
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 58 4e-08
gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 57 8e-08
gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 57 8e-08
gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 57 8e-08
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 55 3e-07
gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens] 52 2e-06
gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens] 51 3e-06
gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens] 49 2e-05
gi|34304360 nephrocystin 3 [Homo sapiens] 48 3e-05
gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo sap... 47 6e-05
gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo sap... 47 6e-05
gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo sap... 47 6e-05
gi|118402596 cell division cycle protein 23 [Homo sapiens] 47 6e-05
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 47 8e-05
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 46 1e-04
gi|189011544 ubiquitously transcribed tetratricopeptide repeat, ... 46 1e-04
gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens] 46 1e-04
gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens] 46 1e-04
gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens] 46 1e-04
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 1496 bits (3872), Expect = 0.0
Identities = 741/741 (100%), Positives = 741/741 (100%)
Query: 1 MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAET 60
MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAET
Sbjct: 1 MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAET 60
Query: 61 PLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISV 120
PLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISV
Sbjct: 61 PLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISV 120
Query: 121 LMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALF 180
LMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALF
Sbjct: 121 LMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALF 180
Query: 181 FLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIG 240
FLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIG
Sbjct: 181 FLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIG 240
Query: 241 KFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTE 300
KFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTE
Sbjct: 241 KFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTE 300
Query: 301 VDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAA 360
VDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAA
Sbjct: 301 VDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAA 360
Query: 361 LWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVG 420
LWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVG
Sbjct: 361 LWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVG 420
Query: 421 YCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPL 480
YCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPL
Sbjct: 421 YCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPL 480
Query: 481 NAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS 540
NAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS
Sbjct: 481 NAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS 540
Query: 541 LAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRH 600
LAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRH
Sbjct: 541 LAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRH 600
Query: 601 VDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLAN 660
VDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLAN
Sbjct: 601 VDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLAN 660
Query: 661 VLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTAS 720
VLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTAS
Sbjct: 661 VLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTAS 720
Query: 721 GTKENYGLLRRKLELMQKKAV 741
GTKENYGLLRRKLELMQKKAV
Sbjct: 721 GTKENYGLLRRKLELMQKKAV 741
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 1496 bits (3872), Expect = 0.0
Identities = 741/741 (100%), Positives = 741/741 (100%)
Query: 1 MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAET 60
MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAET
Sbjct: 20 MAVLDTDLDHILPSSVLPPFWAKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAET 79
Query: 61 PLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISV 120
PLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISV
Sbjct: 80 PLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISV 139
Query: 121 LMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALF 180
LMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALF
Sbjct: 140 LMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALF 199
Query: 181 FLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIG 240
FLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIG
Sbjct: 200 FLLSFLGYCKAFRESNKEGAHSSTFWVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIG 259
Query: 241 KFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTE 300
KFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTE
Sbjct: 260 KFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTE 319
Query: 301 VDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAA 360
VDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAA
Sbjct: 320 VDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAA 379
Query: 361 LWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVG 420
LWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVG
Sbjct: 380 LWFCLIGLICQALCSEDGHKRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVG 439
Query: 421 YCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPL 480
YCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPL
Sbjct: 440 YCVLLTFGFGALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPL 499
Query: 481 NAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS 540
NAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS
Sbjct: 500 NAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS 559
Query: 541 LAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRH 600
LAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRH
Sbjct: 560 LAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRH 619
Query: 601 VDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLAN 660
VDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLAN
Sbjct: 620 VDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLAN 679
Query: 661 VLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTAS 720
VLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTAS
Sbjct: 680 VLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTAS 739
Query: 721 GTKENYGLLRRKLELMQKKAV 741
GTKENYGLLRRKLELMQKKAV
Sbjct: 740 GTKENYGLLRRKLELMQKKAV 760
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 392 bits (1006), Expect = e-109
Identities = 248/694 (35%), Positives = 383/694 (55%), Gaps = 49/694 (7%)
Query: 24 LVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKS 83
L+VG V C+ S FVFDD AI++NKDL TPL L+ +DFWG+ +S SHKS
Sbjct: 11 LIVG-VVTACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKS 69
Query: 84 YRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLH 143
YRPLTVLTFR+NY LS P+ +H++N++ H+ +SV+ + V +L
Sbjct: 70 YRPLTVLTFRLNYLLSE-LKPMSYHLLNMIFHAVVSVIFLKVC--------------KLF 114
Query: 144 LAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSS 203
L ++S++A+LLFAVHP+HTE V GVVGRA+LL ++FFL +FL Y ++ +G +S
Sbjct: 115 LDNKSSVIASLLFAVHPIHTEAVTGVVGRAELLSSIFFLAAFLSYTRS------KGPDNS 168
Query: 204 TFW--VLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNV--LEIVQKVLHKDKSLE 259
W + L++FL AVA LCKEQGITV+G+ V+++ + + + L + K
Sbjct: 169 IIWTPIALTVFLVAVATLCKEQGITVVGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSI 228
Query: 260 NLGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYN 319
ML+ L ++ +L ++ +R +++ + P FT DNPA+ + + R + +N
Sbjct: 229 PFSMLQT---LVKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPAAVSPTP-TRQLTFN 284
Query: 320 YYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCSEDGH 379
Y +NAWLLL P LC DW+MG IPLI+S+ D R +A +FC +G++ G
Sbjct: 285 YLLPVNAWLLLNPSELCCDWTMGTIPLIESLLDIRNLATFT-FFCFLGMLGVFSIRYSGD 343
Query: 380 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKKK 439
+ + + L + +PF+PASNLFF VGFVVAERVLY+PS+G+C+L+ G+ +S + K
Sbjct: 344 SSKTVLMALCLMALPFIPASNLFFPVGFVVAERVLYVPSMGFCILVAHGWQKISTKSVFK 403
Query: 440 KLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQT 499
KL + ++ ++L+ R+ +W SE LF SAL V NAK+ N+G L ++ N
Sbjct: 404 KLSWICLSMVILTHSLKTFHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALENEKNFE 463
Query: 500 AAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSL--------------AVQI 545
A++Y+ +A + P + A N+G K N +EAEE + A +I
Sbjct: 464 RALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQIIPGKKYAARI 523
Query: 546 QPDFAAAWMNL-GIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDAL 604
P+ ++NL +++ + R E A+Q YR AI R + Y + G L +N+ + A
Sbjct: 524 APNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAK 583
Query: 605 NAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGK 664
A+ A L ++ W N+ I+ +A ALEL P +F+ A V+ +
Sbjct: 584 EAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQE 643
Query: 665 SQKYK---ESEALFLKAIKANPNAASYHGNLAVL 695
S + K E+ L I P A+ + NL +L
Sbjct: 644 SGEVKLRPEARKRLLSYINEEPLDANGYFNLGML 677
Score = 55.8 bits (133), Expect = 1e-07
Identities = 52/241 (21%), Positives = 107/241 (44%), Gaps = 10/241 (4%)
Query: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510
+I+ +L+ + ++ + AL + NA + YN+ + A++ + A+
Sbjct: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625
Query: 511 LNPKYVHAMNNLGNILKERNELQ---EAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFE 567
LNPK+ A+ N +++E E++ EA + L + +P A + NLG++ K+
Sbjct: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685
Query: 568 AAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMI-- 625
AE + AIK + + +NL LY+ + + AL P+H +I
Sbjct: 686 EAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRYYPDHI---KGLILK 742
Query: 626 --ILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 683
IL++ ++ A+ LE+ P++ +L V + + ++E L+ + P
Sbjct: 743 GDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALAP 802
Query: 684 N 684
+
Sbjct: 803 H 803
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 377 bits (968), Expect = e-104
Identities = 249/787 (31%), Positives = 387/787 (49%), Gaps = 102/787 (12%)
Query: 22 AKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSH 81
A+LV ++ + + + DF +DDS AI N+DL ETP ++++DFWG+ L+ + SH
Sbjct: 3 AELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSH 62
Query: 82 KSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRR 141
KSYRPL L+FR+N+ + GG +P +H+VN+LLH+ ++ L +L G +T
Sbjct: 63 KSYRPLCTLSFRLNHAI-GGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWT----- 116
Query: 142 LHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAH 201
+A L+FA HP+HTE VAG+VGRAD+ +LFFLLS L Y K + G
Sbjct: 117 --------FMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIK---HCSTRGYS 165
Query: 202 SSTF-WVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLEN 260
+ T+ W L S +ML KEQG+TVL ++AV+D+ V + + +I+ + +
Sbjct: 166 ARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKR------ 219
Query: 261 LGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNY 320
+N L ++LL G+ +L R MG PP+F+ DNPA+ +DS+L R + + Y
Sbjct: 220 ----KNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFY 275
Query: 321 YYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCS----- 375
+ N WLLLCP L FDWSM +PL+K++ DWR + A + L+ L L S
Sbjct: 276 LPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDR 335
Query: 376 -------------EDGHK-------------------------------------RRILT 385
+GH I+
Sbjct: 336 ECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVV 395
Query: 386 LGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKK---KKLI 442
L L L+IPF+PA+NLFF VGFV+AERVLY+PS+G+C+L+T G AL +K K LI
Sbjct: 396 LSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLI 455
Query: 443 AAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAI 502
++ L+ +R+G+W++EE L+RS + V P AK N+G L + + A
Sbjct: 456 FYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISEAE 513
Query: 503 RYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIV--- 559
YR A+ + NLG +L+E + EA LA+ +P A+A++N GI+
Sbjct: 514 SAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMN 573
Query: 560 --------QNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNAT 611
+ LK E +++ + H+ C YNLG+LY + + +AL+ ++ A
Sbjct: 574 QGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAI 633
Query: 612 VLKPEH---SLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKY 668
P +N M L +AE E+L + + +L + +
Sbjct: 634 QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRK 693
Query: 669 KESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGL 728
E+E LFLKAI+ +P + + + L A + + + +LD T N
Sbjct: 694 SEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAH 753
Query: 729 LRRKLEL 735
+ R+ L
Sbjct: 754 MLRQASL 760
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/118 (24%), Positives = 60/118 (50%)
Query: 461 SGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMN 520
+G E+LF A+ + P + + G+ L ++ A ++A L+ +
Sbjct: 690 TGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVF 749
Query: 521 NLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 578
N ++L++ + + AE+ LA +++P++ AA MNLG + + R + AE +Y A++
Sbjct: 750 NAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQ 807
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 307 bits (786), Expect = 3e-83
Identities = 222/635 (34%), Positives = 325/635 (51%), Gaps = 48/635 (7%)
Query: 103 HPVGFHVVNILLHSGIS-VLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFAVHPV 161
+P FH VNI+LH ++ VLM +F K R L + + ALLFAVHP+
Sbjct: 2 NPFYFHAVNIILHCLVTLVLMYTCDKTVF-------KNRGL------AFVTALLFAVHPI 48
Query: 162 HTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSST---FWVLLSIFLGAVAM 218
HTE VAG+VGRAD+L L FLL+FL Y ++ + G+ ST F++LLS+FLG AM
Sbjct: 49 HTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAM 108
Query: 219 LCKEQGITVLGLNAVFDILVI---------GKFNVLEIVQKVLHKDKSLENLGMLRNGGL 269
L KE GITV G+ V+D+ + G Q + SL NG
Sbjct: 109 LVKETGITVFGVCLVYDLFSLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGK- 167
Query: 270 LFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPAS-FADSMLVRAVNYNYYYSLNAWL 328
+ G G + PP P S A ++R + Y+Y + N WL
Sbjct: 168 --QQRFPHKGAWGGCH------SPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWL 219
Query: 329 LLCPWWLCFDWSMGCIPLIKSISDWRVIA--LAALWFCLIGLICQALCSEDGHKRRILTL 386
LL P LC+DW +G IPL+++I D R +A A+ L+ L C A HK + +
Sbjct: 220 LLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMALLSLHCLAAFKRLEHKE--VLV 277
Query: 387 GLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKK---KKLIA 443
GL FLV PF+PASNLFFRVGFVVAERVLY+PS+GYC+L G L + LI
Sbjct: 278 GLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATTLIV 337
Query: 444 AVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIR 503
+ VL +L + + + V ++ W S E LFRS + P NAKVHYN L D+G AI
Sbjct: 338 STVL-LLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIY 396
Query: 504 YYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSL 563
+YR A++L P++ A+NNLG + + + EA+ A+Q+ P A NLG + S
Sbjct: 397 HYRTALKLYPRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQ 453
Query: 564 KRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNN 623
++ E A + +IK+ ++ D Y +L L A+ R +A ++ P+ S NN
Sbjct: 454 EKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNN 513
Query: 624 MIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANP 683
+ L +TG +A A ++A++L P+ H M +L + + +E + +A++
Sbjct: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQV-A 572
Query: 684 NAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPT 718
+ A L LY+ G + A + Y+ + L P+
Sbjct: 573 HKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607
Score = 70.9 bits (172), Expect = 4e-12
Identities = 54/198 (27%), Positives = 90/198 (45%), Gaps = 3/198 (1%)
Query: 536 EELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYA 595
E L VQ P A N R + A YRTA+K ++ NLG L
Sbjct: 361 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR 420
Query: 596 DLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLM 655
D +A ++ A L P+H+ A N+ LL + +A + +++++ P
Sbjct: 421 DT---AEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAY 477
Query: 656 FSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQL 715
SLA++L + +++KE+E ++ IK P+++ H N V G + A HY+ +++L
Sbjct: 478 SSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKL 537
Query: 716 DPTASGTKENYGLLRRKL 733
P+ N G L R L
Sbjct: 538 SPSHHVAMVNLGRLYRSL 555
Score = 64.3 bits (155), Expect = 4e-10
Identities = 73/315 (23%), Positives = 124/315 (39%), Gaps = 80/315 (25%)
Query: 427 FGFGALSKHTKKKK-----LIAAVVLGILFIN---TLRCVLRSGE-WRSEEQLFRSALSV 477
F G L K +KK+ L ++ G F + +L +L E ++ E+++++ +
Sbjct: 444 FNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKN 503
Query: 478 CPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEE 537
CP ++ +H N G L D G A+ +Y++A++L+P + AM NLG + + E AEE
Sbjct: 504 CPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEE 563
Query: 538 LLSLAVQ------IQPDFAAAWMNLGIVQNSLKRFEAA------EQSYRTAI-------- 577
A+Q I A + N G + +L+ ++ A ++ R A+
Sbjct: 564 WYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMG 623
Query: 578 --KHRRKYP-----------DCYYNLGRLYADLNRHVDALNA------------------ 606
K K +CY L +Y+ H AL+A
Sbjct: 624 QTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISEL 683
Query: 607 --------------------WRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 646
+R A L P+ + AW NM + G A A AL+
Sbjct: 684 FFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQ 743
Query: 647 LIPNDHSLMFSLANV 661
L+P+ L +LA +
Sbjct: 744 LVPDSKLLKENLAKL 758
Score = 38.9 bits (89), Expect = 0.017
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 4/106 (3%)
Query: 474 ALSVCPLNAKV----HYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 529
AL + P + KV + G L ++ A YR AV+LNP A N+G I +
Sbjct: 669 ALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIK 728
Query: 530 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 575
+ A A+Q+ PD NL + KR + + +T
Sbjct: 729 GKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVREKDQT 774
Score = 37.4 bits (85), Expect = 0.051
Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 3/97 (3%)
Query: 638 EAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYH 697
E++ R ++ +P++ + ++ AN L + KE+ + A+K P AS NL L
Sbjct: 361 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR 420
Query: 698 RWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLE 734
AK +Y+ +LQL P + N G L + E
Sbjct: 421 DTAE---AKMYYQRALQLHPQHNRALFNLGNLLKSQE 454
Score = 31.6 bits (70), Expect = 2.8
Identities = 20/67 (29%), Positives = 30/67 (44%)
Query: 471 FRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERN 530
+R A+ + P A+ N+G KG +A YY A++L P NL + +
Sbjct: 704 YRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEK 763
Query: 531 ELQEAEE 537
LQE E
Sbjct: 764 RLQEVRE 770
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 113 bits (283), Expect = 6e-25
Identities = 80/310 (25%), Positives = 138/310 (44%), Gaps = 34/310 (10%)
Query: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
G+ + + +R AL + P + N+ L G+ A++ Y A++ NP ++
Sbjct: 93 GQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSD 152
Query: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
LGN+LK L+EA+ A++ QP+FA AW NLG V N+ A + A+
Sbjct: 153 LGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDP 212
Query: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSL---------------------- 619
+ D Y NLG + + A+ A+ A L P H++
Sbjct: 213 NFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTY 272
Query: 620 ------------AWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQK 667
A+ N+ L G++A+AE AL L P + +LAN+ +
Sbjct: 273 RRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGN 332
Query: 668 YKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYG 727
+E+ L+ KA++ P A+ H NLA + + G L A HY+ ++++ PT + N G
Sbjct: 333 IEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMG 392
Query: 728 LLRRKLELMQ 737
++++ +Q
Sbjct: 393 NTLKEMQDVQ 402
Score = 101 bits (251), Expect = 3e-21
Identities = 69/270 (25%), Positives = 123/270 (45%)
Query: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
G + + A+ P A N+G +G AI ++ +AV L+P ++ A N
Sbjct: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
Query: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
LGN+LKE A A+ + P+ A NL V + A +YR AI+ +
Sbjct: 221 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 280
Query: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 641
+PD Y NL + +A + + A L P H+ + NN+ + GN+ +A +
Sbjct: 281 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY 340
Query: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
R+ALE+ P + +LA+VL + K +E+ + +AI+ +P A + N+
Sbjct: 341 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 400
Query: 702 LDLAKKHYEISLQLDPTASGTKENYGLLRR 731
+ A + Y ++Q++P + N + +
Sbjct: 401 VQGALQCYTRAIQINPAFADAHSNLASIHK 430
Score = 94.7 bits (234), Expect = 3e-19
Identities = 67/252 (26%), Positives = 122/252 (48%), Gaps = 10/252 (3%)
Query: 471 FRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERN 530
+R A+ + P + N+ L +KG+ A Y A+RL P + ++NNL NI +E+
Sbjct: 272 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 331
Query: 531 ELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNL 590
++EA L A+++ P+FAAA NL V + + A Y+ AI+ + D Y N+
Sbjct: 332 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
Query: 591 GRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPN 650
G ++ AL + A + P + A +N+ + ++GN+ +A A R AL+L P+
Sbjct: 392 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
Query: 651 DHSLMFSLANVL-------GKSQKYKESEALFLKAIKAN--PNAASYHGNLAVLYHRWGH 701
+LA+ L ++ K+ ++ ++ N P+ +H L L H +
Sbjct: 452 FPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGF-R 510
Query: 702 LDLAKKHYEISL 713
+A++H + L
Sbjct: 511 KAIAERHGNLCL 522
Score = 91.7 bits (226), Expect = 2e-18
Identities = 50/174 (28%), Positives = 91/174 (52%)
Query: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510
+ N + G E + +AL +CP +A N+ ++GN A+R YR+A+
Sbjct: 286 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345
Query: 511 LNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAE 570
+ P++ A +NL ++L+++ +LQEA A++I P FA A+ N+G ++ + A
Sbjct: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405
Query: 571 QSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624
Q Y AI+ + D + NL ++ D +A+ ++R A LKP+ A+ N+
Sbjct: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 459
Score = 91.3 bits (225), Expect = 3e-18
Identities = 67/266 (25%), Positives = 118/266 (44%), Gaps = 1/266 (0%)
Query: 453 NTLRCVLRS-GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRL 511
+ L CV + GE F A+++ P + N+G L + A+ Y A+ L
Sbjct: 185 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL 244
Query: 512 NPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQ 571
+P + NL + E+ + A + A+++QP F A+ NL AE
Sbjct: 245 SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAED 304
Query: 572 SYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNT 631
Y TA++ + D NL + + +A+ +R A + PE + A +N+ +L
Sbjct: 305 CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ 364
Query: 632 GNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGN 691
G L +A +EA+ + P ++ N L + Q + + + +AI+ NP A H N
Sbjct: 365 GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSN 424
Query: 692 LAVLYHRWGHLDLAKKHYEISLQLDP 717
LA ++ G++ A Y +L+L P
Sbjct: 425 LASIHKDSGNIPEAIASYRTALKLKP 450
Score = 82.4 bits (202), Expect = 1e-15
Identities = 65/256 (25%), Positives = 111/256 (43%), Gaps = 34/256 (13%)
Query: 496 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555
G+ AA R+ + R P + L +I + L + +LA++ P A A+ N
Sbjct: 25 GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSN 84
Query: 556 LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYN-------------------------- 589
LG V + + A + YR A++ + + D Y N
Sbjct: 85 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 144
Query: 590 --------LGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 641
LG L L R +A + A +P ++AW+N+ + + G + A
Sbjct: 145 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 204
Query: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
+A+ L PN +L NVL +++ + + A +L+A+ +PN A HGNLA +Y+ G
Sbjct: 205 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 264
Query: 702 LDLAKKHYEISLQLDP 717
+DLA Y +++L P
Sbjct: 265 IDLAIDTYRRAIELQP 280
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/193 (25%), Positives = 91/193 (47%)
Query: 546 QPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALN 605
+PD + L + +R + + AIK + Y NLG +Y + + +A+
Sbjct: 41 EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 100
Query: 606 AWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKS 665
+R+A LKP+ + N+ L G++ A AL+ P+ + + L N+L
Sbjct: 101 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 160
Query: 666 QKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKEN 725
+ +E++A +LKAI+ PN A NL +++ G + LA H+E ++ LDP N
Sbjct: 161 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 220
Query: 726 YGLLRRKLELMQK 738
G + ++ + +
Sbjct: 221 LGNVLKEARIFDR 233
Score = 39.3 bits (90), Expect = 0.013
Identities = 24/80 (30%), Positives = 37/80 (46%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Q + A+ + P A H N+ D GN AI YR A++L P + A NL + L+
Sbjct: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQI 465
Query: 529 RNELQEAEELLSLAVQIQPD 548
+ + +E + V I D
Sbjct: 466 VCDWTDYDERMKKLVSIVAD 485
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 113 bits (283), Expect = 6e-25
Identities = 80/310 (25%), Positives = 138/310 (44%), Gaps = 34/310 (10%)
Query: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
G+ + + +R AL + P + N+ L G+ A++ Y A++ NP ++
Sbjct: 103 GQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSD 162
Query: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
LGN+LK L+EA+ A++ QP+FA AW NLG V N+ A + A+
Sbjct: 163 LGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDP 222
Query: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSL---------------------- 619
+ D Y NLG + + A+ A+ A L P H++
Sbjct: 223 NFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTY 282
Query: 620 ------------AWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQK 667
A+ N+ L G++A+AE AL L P + +LAN+ +
Sbjct: 283 RRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGN 342
Query: 668 YKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYG 727
+E+ L+ KA++ P A+ H NLA + + G L A HY+ ++++ PT + N G
Sbjct: 343 IEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMG 402
Query: 728 LLRRKLELMQ 737
++++ +Q
Sbjct: 403 NTLKEMQDVQ 412
Score = 101 bits (251), Expect = 3e-21
Identities = 69/270 (25%), Positives = 123/270 (45%)
Query: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
G + + A+ P A N+G +G AI ++ +AV L+P ++ A N
Sbjct: 171 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 230
Query: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
LGN+LKE A A+ + P+ A NL V + A +YR AI+ +
Sbjct: 231 LGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQP 290
Query: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 641
+PD Y NL + +A + + A L P H+ + NN+ + GN+ +A +
Sbjct: 291 HFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLY 350
Query: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
R+ALE+ P + +LA+VL + K +E+ + +AI+ +P A + N+
Sbjct: 351 RKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQD 410
Query: 702 LDLAKKHYEISLQLDPTASGTKENYGLLRR 731
+ A + Y ++Q++P + N + +
Sbjct: 411 VQGALQCYTRAIQINPAFADAHSNLASIHK 440
Score = 94.7 bits (234), Expect = 3e-19
Identities = 67/252 (26%), Positives = 122/252 (48%), Gaps = 10/252 (3%)
Query: 471 FRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERN 530
+R A+ + P + N+ L +KG+ A Y A+RL P + ++NNL NI +E+
Sbjct: 282 YRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQG 341
Query: 531 ELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNL 590
++EA L A+++ P+FAAA NL V + + A Y+ AI+ + D Y N+
Sbjct: 342 NIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 401
Query: 591 GRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPN 650
G ++ AL + A + P + A +N+ + ++GN+ +A A R AL+L P+
Sbjct: 402 GNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461
Query: 651 DHSLMFSLANVL-------GKSQKYKESEALFLKAIKAN--PNAASYHGNLAVLYHRWGH 701
+LA+ L ++ K+ ++ ++ N P+ +H L L H +
Sbjct: 462 FPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGF-R 520
Query: 702 LDLAKKHYEISL 713
+A++H + L
Sbjct: 521 KAIAERHGNLCL 532
Score = 91.7 bits (226), Expect = 2e-18
Identities = 50/174 (28%), Positives = 91/174 (52%)
Query: 451 FINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVR 510
+ N + G E + +AL +CP +A N+ ++GN A+R YR+A+
Sbjct: 296 YCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 355
Query: 511 LNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAE 570
+ P++ A +NL ++L+++ +LQEA A++I P FA A+ N+G ++ + A
Sbjct: 356 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 415
Query: 571 QSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624
Q Y AI+ + D + NL ++ D +A+ ++R A LKP+ A+ N+
Sbjct: 416 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL 469
Score = 91.3 bits (225), Expect = 3e-18
Identities = 67/266 (25%), Positives = 118/266 (44%), Gaps = 1/266 (0%)
Query: 453 NTLRCVLRS-GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRL 511
+ L CV + GE F A+++ P + N+G L + A+ Y A+ L
Sbjct: 195 SNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSL 254
Query: 512 NPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQ 571
+P + NL + E+ + A + A+++QP F A+ NL AE
Sbjct: 255 SPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAED 314
Query: 572 SYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNT 631
Y TA++ + D NL + + +A+ +R A + PE + A +N+ +L
Sbjct: 315 CYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ 374
Query: 632 GNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGN 691
G L +A +EA+ + P ++ N L + Q + + + +AI+ NP A H N
Sbjct: 375 GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSN 434
Query: 692 LAVLYHRWGHLDLAKKHYEISLQLDP 717
LA ++ G++ A Y +L+L P
Sbjct: 435 LASIHKDSGNIPEAIASYRTALKLKP 460
Score = 82.4 bits (202), Expect = 1e-15
Identities = 65/256 (25%), Positives = 111/256 (43%), Gaps = 34/256 (13%)
Query: 496 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555
G+ AA R+ + R P + L +I + L + +LA++ P A A+ N
Sbjct: 35 GDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSN 94
Query: 556 LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYN-------------------------- 589
LG V + + A + YR A++ + + D Y N
Sbjct: 95 LGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNP 154
Query: 590 --------LGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVG 641
LG L L R +A + A +P ++AW+N+ + + G + A
Sbjct: 155 DLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHF 214
Query: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
+A+ L PN +L NVL +++ + + A +L+A+ +PN A HGNLA +Y+ G
Sbjct: 215 EKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGL 274
Query: 702 LDLAKKHYEISLQLDP 717
+DLA Y +++L P
Sbjct: 275 IDLAIDTYRRAIELQP 290
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/193 (25%), Positives = 91/193 (47%)
Query: 546 QPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALN 605
+PD + L + +R + + AIK + Y NLG +Y + + +A+
Sbjct: 51 EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIE 110
Query: 606 AWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKS 665
+R+A LKP+ + N+ L G++ A AL+ P+ + + L N+L
Sbjct: 111 HYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKAL 170
Query: 666 QKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKEN 725
+ +E++A +LKAI+ PN A NL +++ G + LA H+E ++ LDP N
Sbjct: 171 GRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYIN 230
Query: 726 YGLLRRKLELMQK 738
G + ++ + +
Sbjct: 231 LGNVLKEARIFDR 243
Score = 39.3 bits (90), Expect = 0.013
Identities = 24/80 (30%), Positives = 37/80 (46%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Q + A+ + P A H N+ D GN AI YR A++L P + A NL + L+
Sbjct: 416 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQI 475
Query: 529 RNELQEAEELLSLAVQIQPD 548
+ + +E + V I D
Sbjct: 476 VCDWTDYDERMKKLVSIVAD 495
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 71.2 bits (173), Expect = 3e-12
Identities = 66/294 (22%), Positives = 130/294 (44%), Gaps = 4/294 (1%)
Query: 448 GILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTA---AIRY 504
G L T C R E+ F AL + P + G + + G+ A A +
Sbjct: 1304 GSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKD 1363
Query: 505 YREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLK 564
+ +A+ +NP Y+ A + G L+ + + Q+A ++A+ P A+ +V +
Sbjct: 1364 FLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Query: 565 RFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624
AA Q A+K + N G ++ + +A+ +++A L P++SLA+ N
Sbjct: 1424 NNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482
Query: 625 IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
+ + +QA +AL+ P + ++ + A +KY+E++ F I++ P
Sbjct: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
Query: 685 AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738
A+ + N A Y+ +LA++ +L L P + +R K+ L+++
Sbjct: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEE 1596
Score = 70.1 bits (170), Expect = 7e-12
Identities = 43/152 (28%), Positives = 73/152 (48%)
Query: 496 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555
G++ A++ Y++A+ LNPKY A N GNI + +A + S A++ P+ MN
Sbjct: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMN 1515
Query: 556 LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKP 615
I LK++E A++ + I+ + Y+N Y L ++ A A LKP
Sbjct: 1516 RAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP 1575
Query: 616 EHSLAWNNMIILLDNTGNLAQAEAVGREALEL 647
+L +N + G + +A A +AL+L
Sbjct: 1576 NDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 71.2 bits (173), Expect = 3e-12
Identities = 66/294 (22%), Positives = 130/294 (44%), Gaps = 4/294 (1%)
Query: 448 GILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTA---AIRY 504
G L T C R E+ F AL + P + G + + G+ A A +
Sbjct: 1304 GSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKD 1363
Query: 505 YREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLK 564
+ +A+ +NP Y+ A + G L+ + + Q+A ++A+ P A+ +V +
Sbjct: 1364 FLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Query: 565 RFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624
AA Q A+K + N G ++ + +A+ +++A L P++SLA+ N
Sbjct: 1424 NNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482
Query: 625 IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
+ + +QA +AL+ P + ++ + A +KY+E++ F I++ P
Sbjct: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
Query: 685 AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738
A+ + N A Y+ +LA++ +L L P + +R K+ L+++
Sbjct: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEE 1596
Score = 70.1 bits (170), Expect = 7e-12
Identities = 43/152 (28%), Positives = 73/152 (48%)
Query: 496 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555
G++ A++ Y++A+ LNPKY A N GNI + +A + S A++ P+ MN
Sbjct: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMN 1515
Query: 556 LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKP 615
I LK++E A++ + I+ + Y+N Y L ++ A A LKP
Sbjct: 1516 RAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP 1575
Query: 616 EHSLAWNNMIILLDNTGNLAQAEAVGREALEL 647
+L +N + G + +A A +AL+L
Sbjct: 1576 NDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 71.2 bits (173), Expect = 3e-12
Identities = 66/294 (22%), Positives = 130/294 (44%), Gaps = 4/294 (1%)
Query: 448 GILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTA---AIRY 504
G L T C R E+ F AL + P + G + + G+ A A +
Sbjct: 1304 GSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKD 1363
Query: 505 YREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLK 564
+ +A+ +NP Y+ A + G L+ + + Q+A ++A+ P A+ +V +
Sbjct: 1364 FLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
Query: 565 RFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624
AA Q A+K + N G ++ + +A+ +++A L P++SLA+ N
Sbjct: 1424 NNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482
Query: 625 IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
+ + +QA +AL+ P + ++ + A +KY+E++ F I++ P
Sbjct: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
Query: 685 AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738
A+ + N A Y+ +LA++ +L L P + +R K+ L+++
Sbjct: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEE 1596
Score = 70.1 bits (170), Expect = 7e-12
Identities = 43/152 (28%), Positives = 73/152 (48%)
Query: 496 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555
G++ A++ Y++A+ LNPKY A N GNI + +A + S A++ P+ MN
Sbjct: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMN 1515
Query: 556 LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKP 615
I LK++E A++ + I+ + Y+N Y L ++ A A LKP
Sbjct: 1516 RAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP 1575
Query: 616 EHSLAWNNMIILLDNTGNLAQAEAVGREALEL 647
+L +N + G + +A A +AL+L
Sbjct: 1576 NDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 57.8 bits (138), Expect = 4e-08
Identities = 38/153 (24%), Positives = 70/153 (45%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
+ F+ A+ V P A + +G A+ +R A+R+NP++ +A LG I +
Sbjct: 594 KFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYK 653
Query: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYY 588
+ + AE A+ I P + ++G+VQ++LK+ E A + AI K P C +
Sbjct: 654 QEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 713
Query: 589 NLGRLYADLNRHVDALNAWRNATVLKPEHSLAW 621
+ + ++ AL + P+ SL +
Sbjct: 714 HRASVLFANEKYKSALQELEELKQIVPKESLVY 746
Score = 57.0 bits (136), Expect = 6e-08
Identities = 46/233 (19%), Positives = 95/233 (40%), Gaps = 34/233 (14%)
Query: 501 AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQ 560
AI++++ A++++P Y +A LG+ EL +A A+++ P AW LG++
Sbjct: 592 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 651
Query: 561 NSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 620
++F AE ++ A+ + ++G + L + AL+ A V+ P++ L
Sbjct: 652 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLC 711
Query: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 680
F A+VL ++KYK + + +
Sbjct: 712 ----------------------------------KFHRASVLFANEKYKSALQELEELKQ 737
Query: 681 ANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKL 733
P + + + +Y + G LA ++ ++ LDP + + + +R L
Sbjct: 738 IVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYL 790
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/255 (19%), Positives = 100/255 (39%), Gaps = 28/255 (10%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAI-----RYYREAVRLNPKYVHAMNNLG 523
++ + L++C N K NI +L T + R Y E +Y+ A
Sbjct: 474 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFEL----SEYMQAERIFS 529
Query: 524 NILKERNELQEAEELLSLAV-QIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRK 582
+ + N E E+ S + +Q D A L ++ L + +
Sbjct: 530 EVRRIENYRVEGMEIYSTTLWHLQKDVA-----LSVLSKDLTDMD-------------KN 571
Query: 583 YPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGR 642
P+ + G ++ H A+ ++ A + P ++ A+ + T L +A A R
Sbjct: 572 SPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFR 631
Query: 643 EALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHL 702
A+ + P ++ + L + K +K+ +E F KA+ NP ++ ++ V+ H
Sbjct: 632 NAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 691
Query: 703 DLAKKHYEISLQLDP 717
+ A ++ +DP
Sbjct: 692 EKALDTLNKAIVIDP 706
Score = 36.6 bits (83), Expect = 0.087
Identities = 21/97 (21%), Positives = 50/97 (51%)
Query: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
+ A+++ PN L + +++ ++ A F AI+ NP + L ++Y++
Sbjct: 597 QRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEK 656
Query: 702 LDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738
LA+ H++ +L ++P +S + G+++ L+ +K
Sbjct: 657 FSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 693
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 57.8 bits (138), Expect = 4e-08
Identities = 38/153 (24%), Positives = 70/153 (45%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
+ F+ A+ V P A + +G A+ +R A+R+NP++ +A LG I +
Sbjct: 588 KFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYK 647
Query: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYY 588
+ + AE A+ I P + ++G+VQ++LK+ E A + AI K P C +
Sbjct: 648 QEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKF 707
Query: 589 NLGRLYADLNRHVDALNAWRNATVLKPEHSLAW 621
+ + ++ AL + P+ SL +
Sbjct: 708 HRASVLFANEKYKSALQELEELKQIVPKESLVY 740
Score = 57.0 bits (136), Expect = 6e-08
Identities = 46/233 (19%), Positives = 95/233 (40%), Gaps = 34/233 (14%)
Query: 501 AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQ 560
AI++++ A++++P Y +A LG+ EL +A A+++ P AW LG++
Sbjct: 586 AIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIY 645
Query: 561 NSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 620
++F AE ++ A+ + ++G + L + AL+ A V+ P++ L
Sbjct: 646 YKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLC 705
Query: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 680
F A+VL ++KYK + + +
Sbjct: 706 ----------------------------------KFHRASVLFANEKYKSALQELEELKQ 731
Query: 681 ANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKL 733
P + + + +Y + G LA ++ ++ LDP + + + +R L
Sbjct: 732 IVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYL 784
Score = 42.4 bits (98), Expect = 0.002
Identities = 50/255 (19%), Positives = 100/255 (39%), Gaps = 28/255 (10%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAI-----RYYREAVRLNPKYVHAMNNLG 523
++ + L++C N K NI +L T + R Y E +Y+ A
Sbjct: 468 EMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFEL----SEYMQAERIFS 523
Query: 524 NILKERNELQEAEELLSLAV-QIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRK 582
+ + N E E+ S + +Q D A L ++ L + +
Sbjct: 524 EVRRIENYRVEGMEIYSTTLWHLQKDVA-----LSVLSKDLTDMD-------------KN 565
Query: 583 YPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGR 642
P+ + G ++ H A+ ++ A + P ++ A+ + T L +A A R
Sbjct: 566 SPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFR 625
Query: 643 EALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHL 702
A+ + P ++ + L + K +K+ +E F KA+ NP ++ ++ V+ H
Sbjct: 626 NAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKS 685
Query: 703 DLAKKHYEISLQLDP 717
+ A ++ +DP
Sbjct: 686 EKALDTLNKAIVIDP 700
Score = 36.6 bits (83), Expect = 0.087
Identities = 21/97 (21%), Positives = 50/97 (51%)
Query: 642 REALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH 701
+ A+++ PN L + +++ ++ A F AI+ NP + L ++Y++
Sbjct: 591 QRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEK 650
Query: 702 LDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738
LA+ H++ +L ++P +S + G+++ L+ +K
Sbjct: 651 FSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEK 687
>gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo
sapiens]
Length = 515
Score = 56.6 bits (135), Expect = 8e-08
Identities = 48/218 (22%), Positives = 97/218 (44%), Gaps = 3/218 (1%)
Query: 470 LFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 529
LF+ L P + I + + N ++A YY+E ++ + +V A+ +G+
Sbjct: 280 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 339
Query: 530 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAI---KHRRKYPDC 586
++ + A +Q+ + NLG+ ++++ S+ A+ ++ + D
Sbjct: 340 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 399
Query: 587 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 646
+YNLG + + A +R A V H+ A+NN+ +L G++ QA A+ + A
Sbjct: 400 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 459
Query: 647 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
L P+ + F+ A + K + S K+ A P+
Sbjct: 460 LAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPD 497
Score = 35.4 bits (80), Expect = 0.19
Identities = 53/289 (18%), Positives = 100/289 (34%), Gaps = 38/289 (13%)
Query: 456 RCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKY 515
+C R G +R E+ F+SAL + Y + K A+ +++ + P
Sbjct: 233 KCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGE 291
Query: 516 VHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 575
V + + I +E N + A E Y+
Sbjct: 292 VTLLCGIARIYEEMNNMSSAAEY----------------------------------YKE 317
Query: 576 AIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLA 635
+K + + +G + ++ AL +R + + +NN+ +
Sbjct: 318 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 377
Query: 636 QAEAVGREALELIPNDHS---LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNL 692
AL L N+ + ++L +V + F A+ N N A + NL
Sbjct: 378 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 437
Query: 693 AVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV 741
AVL R GH++ A+ + + L P N+ + K+ +Q+ V
Sbjct: 438 AVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYV 486
>gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo
sapiens]
Length = 475
Score = 56.6 bits (135), Expect = 8e-08
Identities = 48/218 (22%), Positives = 97/218 (44%), Gaps = 3/218 (1%)
Query: 470 LFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 529
LF+ L P + I + + N ++A YY+E ++ + +V A+ +G+
Sbjct: 240 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 299
Query: 530 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAI---KHRRKYPDC 586
++ + A +Q+ + NLG+ ++++ S+ A+ ++ + D
Sbjct: 300 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 359
Query: 587 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 646
+YNLG + + A +R A V H+ A+NN+ +L G++ QA A+ + A
Sbjct: 360 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 419
Query: 647 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
L P+ + F+ A + K + S K+ A P+
Sbjct: 420 LAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPD 457
Score = 38.1 bits (87), Expect = 0.030
Identities = 69/366 (18%), Positives = 129/366 (35%), Gaps = 49/366 (13%)
Query: 380 KRRILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALS-KHTKK 438
++ I T + P +S F R+G + E + + + V ALS +H++
Sbjct: 126 EQAIRTPRTAYTARPITSSSGRFVRLGTALFEYIFHHEND---VKTALDLAALSTEHSQY 182
Query: 439 KKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQ 498
K V +G +C R G +R E+ F+SAL + Y + K
Sbjct: 183 KDWWWKVQIG-------KCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQP 234
Query: 499 TAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGI 558
A+ +++ + P V + + I +E N + A E
Sbjct: 235 VTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEY-------------------- 274
Query: 559 VQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHS 618
Y+ +K + + +G + ++ AL +R + +
Sbjct: 275 --------------YKEVLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNG 320
Query: 619 LAWNNMIILLDNTGNLAQAEAVGREALELIPNDHS---LMFSLANVLGKSQKYKESEALF 675
+NN+ + AL L N+ + ++L +V + F
Sbjct: 321 QLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCF 380
Query: 676 LKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLEL 735
A+ N N A + NLAVL R GH++ A+ + + L P N+ + K+
Sbjct: 381 RLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGD 440
Query: 736 MQKKAV 741
+Q+ V
Sbjct: 441 LQRSYV 446
>gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo
sapiens]
Length = 505
Score = 56.6 bits (135), Expect = 8e-08
Identities = 48/218 (22%), Positives = 97/218 (44%), Gaps = 3/218 (1%)
Query: 470 LFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKER 529
LF+ L P + I + + N ++A YY+E ++ + +V A+ +G+
Sbjct: 270 LFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKEVLKQDNTHVEAIACIGSNHFYS 329
Query: 530 NELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAI---KHRRKYPDC 586
++ + A +Q+ + NLG+ ++++ S+ A+ ++ + D
Sbjct: 330 DQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYDMTLTSFERALSLAENEEEAADV 389
Query: 587 YYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALE 646
+YNLG + + A +R A V H+ A+NN+ +L G++ QA A+ + A
Sbjct: 390 WYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNLAVLEMRKGHVEQARALLQTASS 449
Query: 647 LIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684
L P+ + F+ A + K + S K+ A P+
Sbjct: 450 LAPHMYEPHFNFATISDKIGDLQRSYVAAQKSEAAFPD 487
Score = 35.4 bits (80), Expect = 0.19
Identities = 53/289 (18%), Positives = 100/289 (34%), Gaps = 38/289 (13%)
Query: 456 RCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKY 515
+C R G +R E+ F+SAL + Y + K A+ +++ + P
Sbjct: 223 KCYYRLGMYREAEKQFKSALKQQEMVDTFLY-LAKVYVSLDQPVTALNLFKQGLDKFPGE 281
Query: 516 VHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRT 575
V + + I +E N + A E Y+
Sbjct: 282 VTLLCGIARIYEEMNNMSSAAEY----------------------------------YKE 307
Query: 576 AIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNLA 635
+K + + +G + ++ AL +R + + +NN+ +
Sbjct: 308 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLCCFYAQQYD 367
Query: 636 QAEAVGREALELIPNDHS---LMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNL 692
AL L N+ + ++L +V + F A+ N N A + NL
Sbjct: 368 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 427
Query: 693 AVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKKAV 741
AVL R GH++ A+ + + L P N+ + K+ +Q+ V
Sbjct: 428 AVLEMRKGHVEQARALLQTASSLAPHMYEPHFNFATISDKIGDLQRSYV 476
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 54.7 bits (130), Expect = 3e-07
Identities = 68/304 (22%), Positives = 113/304 (37%), Gaps = 39/304 (12%)
Query: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
G + +LF++ + P +A + ++L G AAI Y EA +LN K +N
Sbjct: 81 GNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHN 140
Query: 522 LGNI---LKERNELQE------------------------------AEELLSLAVQIQPD 548
LG LK+ N+ Q+ A E+ AV+ P+
Sbjct: 141 LGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPE 200
Query: 549 FAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD---ALN 605
LG++ L ++ A + A+ + P Y + + + H D AL
Sbjct: 201 NTELLTTLGLLYLQLGIYQKAFEHLGNALTYD---PTNYKAILAAGSMMQTHGDFDVALT 257
Query: 606 AWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKS 665
+R PE WNN+ + A + + A L P D ++++L V
Sbjct: 258 KYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTM 317
Query: 666 QKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKEN 725
Q+Y + AI P + LAV ++ AK+ Y ++ LD N
Sbjct: 318 QQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLN 377
Query: 726 YGLL 729
Y +L
Sbjct: 378 YAVL 381
Score = 50.1 bits (118), Expect = 8e-06
Identities = 52/241 (21%), Positives = 96/241 (39%), Gaps = 3/241 (1%)
Query: 488 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQP 547
+GK +G+ AI Y++AV +P+ + LG + + Q+A E L A+ P
Sbjct: 174 LGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
Query: 548 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAW 607
A + G + + F+ A YR + P + N+G + ++V A++
Sbjct: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCL 293
Query: 608 RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQK 667
+ A L P N+ ++ A A A+ P L LA L +
Sbjct: 294 KRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLED 353
Query: 668 YKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYG 727
+ ++ + +A+ + + N AVL + G A Y+ +++ S K+N
Sbjct: 354 IENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQ---EMEKKVSLLKDNSS 410
Query: 728 L 728
L
Sbjct: 411 L 411
Score = 44.3 bits (103), Expect = 4e-04
Identities = 51/213 (23%), Positives = 86/213 (40%), Gaps = 10/213 (4%)
Query: 447 LGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYR 506
LG+L+ L+ G ++ + +AL+ P N K G + G+ A+ YR
Sbjct: 208 LGLLY-------LQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKYR 260
Query: 507 EAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRF 566
P+ NN+G + + A L A + P NLG+V +++++
Sbjct: 261 VVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQY 320
Query: 567 EAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMII 626
+A AI + K + Y L +L +A A+ A L + L N +
Sbjct: 321 ASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAV 380
Query: 627 LLDNTGNLAQAEAVGRE---ALELIPNDHSLMF 656
LL N G A A +E + L+ ++ SL F
Sbjct: 381 LLYNQGEKKNALAQYQEMEKKVSLLKDNSSLEF 413
>gi|110225358 tetratricopeptide repeat domain 7A [Homo sapiens]
Length = 858
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/113 (30%), Positives = 55/113 (48%)
Query: 472 RSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNE 531
+ A + P + V Y G+ KGN A + Y+EA+ +NP V M++LG +L
Sbjct: 735 QEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGH 794
Query: 532 LQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYP 584
A+++L AV+ Q AW LG V + + EAA + TA++ P
Sbjct: 795 KSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELEASSP 847
Score = 38.9 bits (89), Expect = 0.017
Identities = 22/87 (25%), Positives = 40/87 (45%)
Query: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 680
W L +L +A +EA L P HS+++ + +E++ L+ +A+
Sbjct: 714 WLQAAELFMEQQHLKEAGFCIQEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALT 773
Query: 681 ANPNAASYHGNLAVLYHRWGHLDLAKK 707
NP+ +L ++ R GH LA+K
Sbjct: 774 VNPDGVRIMHSLGLMLSRLGHKSLAQK 800
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/85 (23%), Positives = 45/85 (52%)
Query: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNN 521
G +QL++ AL+V P ++ +++G L+ G+++ A + R+AV A
Sbjct: 759 GNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGHKSLAQKVLRDAVERQSTCHEAWQG 818
Query: 522 LGNILKERNELQEAEELLSLAVQIQ 546
LG +L+ + + + A + A++++
Sbjct: 819 LGEVLQAQGQNEAAVDCFLTALELE 843
Score = 35.8 bits (81), Expect = 0.15
Identities = 23/109 (21%), Positives = 51/109 (46%)
Query: 506 REAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKR 565
+EA L P + G + + + L+EA++L A+ + PD +LG++ + L
Sbjct: 735 QEAAGLFPTSHSVLYMRGRLAEVKGNLEEAKQLYKEALTVNPDGVRIMHSLGLMLSRLGH 794
Query: 566 FEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLK 614
A++ R A++ + + + LG + ++ A++ + A L+
Sbjct: 795 KSLAQKVLRDAVERQSTCHEAWQGLGEVLQAQGQNEAAVDCFLTALELE 843
>gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens]
Length = 843
Score = 51.2 bits (121), Expect = 3e-06
Identities = 32/113 (28%), Positives = 55/113 (48%)
Query: 472 RSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNE 531
+ A ++ P++ V Y G+ +G+ A R+Y EA+ ++P +V +M L IL +
Sbjct: 720 QEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGR 779
Query: 532 LQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYP 584
AE++L AVQ+ W LG V + AA + + TA++ P
Sbjct: 780 YSLAEKILRDAVQVNSTAHEVWNGLGEVLQAQGNDAAATECFLTALELEASSP 832
Score = 32.7 bits (73), Expect = 1.2
Identities = 20/87 (22%), Positives = 37/87 (42%), Gaps = 1/87 (1%)
Query: 595 ADLNRHVDALNAW-RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHS 653
A+L +D W A + P H + + ++L G + AE + R+A+++ H
Sbjct: 740 AELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHE 799
Query: 654 LMFSLANVLGKSQKYKESEALFLKAIK 680
+ L VL + FL A++
Sbjct: 800 VWNGLGEVLQAQGNDAAATECFLTALE 826
>gi|42476022 tetratricopeptide repeat domain 27 [Homo sapiens]
Length = 843
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 11/193 (5%)
Query: 457 CVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAA--IRYYREAVRLNPK 514
C R+G+ E++ R L ++ +G L D A + YR A K
Sbjct: 475 CYERAGQHGKAEEILRQELEKKE-TPSLYCLLGDVLGDHSCYDKAWELSRYRSARAQRSK 533
Query: 515 YVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYR 574
+ + N E QE E +V+I P W +LG +L+ ++ + ++++
Sbjct: 534 ALLHLRN--------KEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQ 585
Query: 575 TAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDNTGNL 634
+ + + NL Y L + V A + A EH W N I+ + G
Sbjct: 586 RCVTLEPDNAEAWNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEF 645
Query: 635 AQAEAVGREALEL 647
++A L+L
Sbjct: 646 SEAIKAYHRLLDL 658
Score = 40.4 bits (93), Expect = 0.006
Identities = 39/184 (21%), Positives = 74/184 (40%), Gaps = 14/184 (7%)
Query: 502 IRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQN 561
+ + +V++NP + +LG + Q + + V ++PD A AW NL
Sbjct: 547 VECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDNAEAWNNLSTSYI 606
Query: 562 SLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAW 621
LK+ A ++ + A+K ++ + N D+ +A+ A+ L+ ++
Sbjct: 607 RLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKYKDVQ 666
Query: 622 NNMII-------LLDNTGNLAQA------EAVGREALELIPNDHSLMFSLANVLGKSQKY 668
I+ + D +G++A E GR + ND + A+V G Q
Sbjct: 667 VLKILVRAVIDGMTDRSGDVATGLKGKLQELFGR-VTSRVTNDGEIWRLYAHVYGNGQSE 725
Query: 669 KESE 672
K E
Sbjct: 726 KPDE 729
Score = 38.9 bits (89), Expect = 0.017
Identities = 26/127 (20%), Positives = 52/127 (40%)
Query: 459 LRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHA 518
LR+ E++ + F ++ + P+ V +++G + + + ++ V L P A
Sbjct: 538 LRNKEFQECVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDNAEA 597
Query: 519 MNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 578
NNL + +A L A++ + W N + + F A ++Y +
Sbjct: 598 WNNLSTSYIRLKQKVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLD 657
Query: 579 HRRKYPD 585
R KY D
Sbjct: 658 LRDKYKD 664
>gi|34304360 nephrocystin 3 [Homo sapiens]
Length = 1330
Score = 48.1 bits (113), Expect = 3e-05
Identities = 45/209 (21%), Positives = 88/209 (42%), Gaps = 32/209 (15%)
Query: 479 PLNAKVHYNIGKNLADKGNQTAAIRYYREAVRL--------NPKYVHAMNNLGNILKERN 530
P NA+ +G + N A ++ + ++ + +P ++NNL + E+
Sbjct: 1090 PDNARTLNELGVLYYLQNNLETADQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKK 1149
Query: 531 ELQEAEELLSLAVQIQ--------PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRK 582
+ +AEEL A+ I+ P A +L I+ + + + A Y A++ R+K
Sbjct: 1150 QYDKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKMGKLDKAVPLYELAVEIRQK 1209
Query: 583 -----YPD---CYYNLGRLYADLNRHVDALNAWRNATV--------LKPEHSLAWNNMII 626
+P NL LY+ + +HV+AL + A + P N+ +
Sbjct: 1210 SFGPKHPSVATALVNLAVLYSQMKKHVEALPLYERALKIYEDSLGRMHPRVGETLKNLAV 1269
Query: 627 LLDNTGNLAQAEAVGREALELIPNDHSLM 655
L G+ +A + + A+E+ + SL+
Sbjct: 1270 LSYEGGDFEKAAELYKRAMEIKEAETSLL 1298
Score = 45.8 bits (107), Expect = 1e-04
Identities = 59/276 (21%), Positives = 119/276 (43%), Gaps = 38/276 (13%)
Query: 482 AKVHYNIGKNLADKGNQTAAIRYYREAVRL--------NPKYVHAMNNLGNILKERNELQ 533
A ++ +G+ L D G + AI + ++ + +P+ +++ L ++ + +
Sbjct: 943 ADLYETLGRFLKDLGLLSQAIVPLQRSLEIRETALDPDHPRVAQSLHQLASVYVQWKKFG 1002
Query: 534 EAEELLSLAVQIQ--------PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPD 585
AE+L A++I P A L + ++E AE + + K +K
Sbjct: 1003 NAEQLYKQALEISENAYGADHPYTARELEALATLYQKQNKYEQAEHFRKKSFKIHQK--- 1059
Query: 586 CYYNLGRLYADLNRHVDALNAWRNATVLK--PEHSLAWNNMIILLDNTGNLAQAEAVGRE 643
G LY AL T+ K P+++ N + +L NL A+ +
Sbjct: 1060 AIKKKGNLYGFALLRRRALQL-EELTLGKDTPDNARTLNELGVLYYLQNNLETADQFLKR 1118
Query: 644 ALEL----IPNDH----SLMFSLANVLGKSQKYKESEALFLKAIKA--------NPNAAS 687
+LE+ + DH + +LA + + ++Y ++E L+ +A+ +P+ A
Sbjct: 1119 SLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYDKAEELYERALDIRRRALAPDHPSLAY 1178
Query: 688 YHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTK 723
+LA+LY + G LD A YE+++++ + G K
Sbjct: 1179 TVKHLAILYKKMGKLDKAVPLYELAVEIRQKSFGPK 1214
>gi|33188431 tetratricopeptide repeat protein isoform 3 [Homo
sapiens]
Length = 1347
Score = 47.0 bits (110), Expect = 6e-05
Identities = 46/200 (23%), Positives = 90/200 (45%), Gaps = 24/200 (12%)
Query: 447 LGILF-INTLRCVLRSGEWRSEEQLFRSALSVCP----LNAKVHYNIGKNLADKGNQTAA 501
LG++F +NT +++S + F+ AL C NA++ ++I + +A
Sbjct: 170 LGLMFKVNT--------DYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSA 221
Query: 502 IRYYREAVRLN--PKYVHAM---------NNLGNILKERNELQEAEELLSLAVQIQPDFA 550
Y + ++ P V A +N+ + + + A + L +++ P+
Sbjct: 222 KEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSG 281
Query: 551 AAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNA 610
+W LG +S+ + + A SYR +I D + ++G LY N+ +DAL A+ A
Sbjct: 282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 341
Query: 611 TVLKPEHSLAWNNMIILLDN 630
L H+ AW ++ L ++
Sbjct: 342 VQLDHGHAAAWMDLGTLYES 361
Score = 45.1 bits (105), Expect = 2e-04
Identities = 27/113 (23%), Positives = 55/113 (48%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Q + +L P + + Y +G+ + G A YR+++ + ++G + ++
Sbjct: 268 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
Query: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
+N+ +A + AVQ+ AAAWM+LG + S + + A + Y A + +R
Sbjct: 328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKR 380
Score = 40.0 bits (92), Expect = 0.008
Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 2/128 (1%)
Query: 484 VHYNIGKNLADKGNQTA-AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLA 542
+H+N+ + DK + + AI+Y ++++ +P + LG ++Q+A +
Sbjct: 249 MHHNMDL-VGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQS 307
Query: 543 VQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD 602
+ A W ++G++ + A Q+Y A++ + + +LG LY N+ D
Sbjct: 308 IDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQD 367
Query: 603 ALNAWRNA 610
A+ + NA
Sbjct: 368 AIKCYLNA 375
>gi|33188429 tetratricopeptide repeat protein isoform 1 [Homo
sapiens]
Length = 1079
Score = 47.0 bits (110), Expect = 6e-05
Identities = 46/200 (23%), Positives = 90/200 (45%), Gaps = 24/200 (12%)
Query: 447 LGILF-INTLRCVLRSGEWRSEEQLFRSALSVCP----LNAKVHYNIGKNLADKGNQTAA 501
LG++F +NT +++S + F+ AL C NA++ ++I + +A
Sbjct: 170 LGLMFKVNT--------DYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSA 221
Query: 502 IRYYREAVRLN--PKYVHAM---------NNLGNILKERNELQEAEELLSLAVQIQPDFA 550
Y + ++ P V A +N+ + + + A + L +++ P+
Sbjct: 222 KEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSG 281
Query: 551 AAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNA 610
+W LG +S+ + + A SYR +I D + ++G LY N+ +DAL A+ A
Sbjct: 282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 341
Query: 611 TVLKPEHSLAWNNMIILLDN 630
L H+ AW ++ L ++
Sbjct: 342 VQLDHGHAAAWMDLGTLYES 361
Score = 45.1 bits (105), Expect = 2e-04
Identities = 27/113 (23%), Positives = 55/113 (48%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Q + +L P + + Y +G+ + G A YR+++ + ++G + ++
Sbjct: 268 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
Query: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
+N+ +A + AVQ+ AAAWM+LG + S + + A + Y A + +R
Sbjct: 328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKR 380
Score = 40.0 bits (92), Expect = 0.008
Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 2/128 (1%)
Query: 484 VHYNIGKNLADKGNQTA-AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLA 542
+H+N+ + DK + + AI+Y ++++ +P + LG ++Q+A +
Sbjct: 249 MHHNMDL-VGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQS 307
Query: 543 VQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD 602
+ A W ++G++ + A Q+Y A++ + + +LG LY N+ D
Sbjct: 308 IDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQD 367
Query: 603 ALNAWRNA 610
A+ + NA
Sbjct: 368 AIKCYLNA 375
>gi|33188427 tetratricopeptide repeat protein isoform 2 [Homo
sapiens]
Length = 1240
Score = 47.0 bits (110), Expect = 6e-05
Identities = 46/200 (23%), Positives = 90/200 (45%), Gaps = 24/200 (12%)
Query: 447 LGILF-INTLRCVLRSGEWRSEEQLFRSALSVCP----LNAKVHYNIGKNLADKGNQTAA 501
LG++F +NT +++S + F+ AL C NA++ ++I + +A
Sbjct: 170 LGLMFKVNT--------DYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSA 221
Query: 502 IRYYREAVRLN--PKYVHAM---------NNLGNILKERNELQEAEELLSLAVQIQPDFA 550
Y + ++ P V A +N+ + + + A + L +++ P+
Sbjct: 222 KEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSG 281
Query: 551 AAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNA 610
+W LG +S+ + + A SYR +I D + ++G LY N+ +DAL A+ A
Sbjct: 282 QSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICA 341
Query: 611 TVLKPEHSLAWNNMIILLDN 630
L H+ AW ++ L ++
Sbjct: 342 VQLDHGHAAAWMDLGTLYES 361
Score = 45.1 bits (105), Expect = 2e-04
Identities = 27/113 (23%), Positives = 55/113 (48%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Q + +L P + + Y +G+ + G A YR+++ + ++G + ++
Sbjct: 268 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 327
Query: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
+N+ +A + AVQ+ AAAWM+LG + S + + A + Y A + +R
Sbjct: 328 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKR 380
Score = 40.0 bits (92), Expect = 0.008
Identities = 28/128 (21%), Positives = 60/128 (46%), Gaps = 2/128 (1%)
Query: 484 VHYNIGKNLADKGNQTA-AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLA 542
+H+N+ + DK + + AI+Y ++++ +P + LG ++Q+A +
Sbjct: 249 MHHNMDL-VGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQS 307
Query: 543 VQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVD 602
+ A W ++G++ + A Q+Y A++ + + +LG LY N+ D
Sbjct: 308 IDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQD 367
Query: 603 ALNAWRNA 610
A+ + NA
Sbjct: 368 AIKCYLNA 375
>gi|118402596 cell division cycle protein 23 [Homo sapiens]
Length = 597
Score = 47.0 bits (110), Expect = 6e-05
Identities = 28/97 (28%), Positives = 47/97 (48%)
Query: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRR 581
+GN R++ ++A A+++ P + AW +G +K AA Q+YR AI+ +
Sbjct: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
Query: 582 KYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHS 618
+ +Y LG+ Y L L +R A L+P S
Sbjct: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDS 433
Score = 43.5 bits (101), Expect = 7e-04
Identities = 33/122 (27%), Positives = 50/122 (40%), Gaps = 1/122 (0%)
Query: 488 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQP 547
IG + + A Y++ A++LNP+Y+ A +G+ E A + A+++
Sbjct: 337 IGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNK 396
Query: 548 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNA- 606
AW LG LK YR A + R LG Y LN+ V+A
Sbjct: 397 RDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCY 456
Query: 607 WR 608
WR
Sbjct: 457 WR 458
Score = 37.4 bits (85), Expect = 0.051
Identities = 34/178 (19%), Positives = 69/178 (38%)
Query: 501 AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQ 560
A+ + E + +P + M+ N+L R+ E L +I +G
Sbjct: 282 ALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYY 341
Query: 561 NSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 620
+ + E A ++ A+K +Y + +G Y ++ A+ A+R+A + A
Sbjct: 342 SLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRA 401
Query: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKA 678
W + + R A +L PND ++ +L K + E++ + +A
Sbjct: 402 WYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRA 459
Score = 34.7 bits (78), Expect = 0.33
Identities = 33/140 (23%), Positives = 56/140 (40%), Gaps = 11/140 (7%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Q +R A+ V + + Y +G+ + YYR A +L P + LG ++
Sbjct: 386 QAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEK 445
Query: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYY 588
N+L EA++ A + A + L + L E A Q Y KY Y
Sbjct: 446 LNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCY-------IKYIQDIY 498
Query: 589 NLGRLYADLNRHVDALNAWR 608
+ G ++ H++ A+R
Sbjct: 499 SCG----EIVEHLEESTAFR 514
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 46.6 bits (109), Expect = 8e-05
Identities = 21/90 (23%), Positives = 47/90 (52%)
Query: 494 DKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAW 553
+K +Q A+ Y++ +R + K ++A N +G +L + +EA ++ + + D + W
Sbjct: 625 EKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVW 684
Query: 554 MNLGIVQNSLKRFEAAEQSYRTAIKHRRKY 583
+NL + K++ +A Q Y ++ K+
Sbjct: 685 LNLAHIYVEQKQYISAVQMYENCLRKFYKH 714
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/215 (18%), Positives = 86/215 (40%), Gaps = 14/215 (6%)
Query: 480 LNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELL 539
++ YN+ + A + Y+ +R +P YV LG + +++ EA +
Sbjct: 495 ISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWF 554
Query: 540 SLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCY--YNLGRLYADL 597
A+QI D AW +G + + + + ++ + +K D Y LG ++
Sbjct: 555 KEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQT 614
Query: 598 -----------NRHVD-ALNAWRNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREAL 645
RH D AL ++ ++ A N + +L + G +A V +
Sbjct: 615 LHQPTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVR 674
Query: 646 ELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIK 680
E + + +LA++ + ++Y + ++ ++
Sbjct: 675 EATADISDVWLNLAHIYVEQKQYISAVQMYENCLR 709
Score = 37.7 bits (86), Expect = 0.039
Identities = 57/255 (22%), Positives = 99/255 (38%), Gaps = 24/255 (9%)
Query: 462 GEWRSEEQLFRSALSVCPLNAKVHYNIGKNLA---DKGNQTAAIRYYREAVRLNPKYVHA 518
G+ + Q F L P N + +G A D+ + A + ++ P V A
Sbjct: 355 GDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEA 414
Query: 519 MNNLGNILKERNELQEAEELLSLAVQI-----QPDFAAAWMN--------LGIVQNSLKR 565
L IL E+ ++Q A A +I Q D +N LG + + K
Sbjct: 415 WIELAQIL-EQTDIQGALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKY 473
Query: 566 FEAAEQSYRTAIKHRRKYPDCY-----YNLGRLYADLNRHVDALNAWRNATVLKPEHSLA 620
F A+ + +H Y + YNL RLY + +A ++N P +
Sbjct: 474 FLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDC 533
Query: 621 WNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSL-ANVLGKSQKYKESEALFLKAI 679
+ + + + GN +A +EAL+ I DH +SL N+ Q++ + F + +
Sbjct: 534 YLRLGAMARDKGNFYEASDWFKEALQ-INQDHPDAWSLIGNLHLAKQEWGPGQKKFERIL 592
Query: 680 KANPNAASYHGNLAV 694
K + + LA+
Sbjct: 593 KQPSTQSDTYSMLAL 607
Score = 35.8 bits (81), Expect = 0.15
Identities = 56/285 (19%), Positives = 117/285 (41%), Gaps = 26/285 (9%)
Query: 480 LNAKVHYNIGKNLADKGNQTAAIRYYREAVRL-NPKYVHAMNNLGNILKERNELQEAEEL 538
+ A+ Y + ++ + + A +YY +A + + +V LG + R + + A +
Sbjct: 304 MQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQC 363
Query: 539 LSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPD---CYYNLGRLYA 595
++ P+ LG + + + E + + K +YPD + L ++
Sbjct: 364 FEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILE 423
Query: 596 DLNRHVDALNAWRNATVLKPEHSLA------WNNMIILLDNTGNLAQAE-----AVGREA 644
+ AL+A+ AT + E A NN+ L GNL +A+ ++ R
Sbjct: 424 QTDIQ-GALSAYGTATRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAK 482
Query: 645 LELIPNDH-------SLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYH 697
E ++H + ++LA + ++ E+E L+ ++ +PN + L +
Sbjct: 483 AEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYVDCYLRLGAMAR 542
Query: 698 RWGHLDLAKKHYEISLQLD---PTASGTKENYGLLRRKLELMQKK 739
G+ A ++ +LQ++ P A N L +++ QKK
Sbjct: 543 DKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKK 587
Score = 32.7 bits (73), Expect = 1.2
Identities = 23/113 (20%), Positives = 49/113 (43%), Gaps = 1/113 (0%)
Query: 457 CVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKY- 515
C+L + + F L+ P N +K + A+ YY++A+R NP
Sbjct: 138 CLLEGDKMDQADAQFHFVLNQSPNNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCP 197
Query: 516 VHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEA 568
+G+ + N+L++A S A+++ A + L +++ + K ++
Sbjct: 198 AEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADS 250
>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
protein) [Homo sapiens]
Length = 543
Score = 46.2 bits (108), Expect = 1e-04
Identities = 28/109 (25%), Positives = 47/109 (43%)
Query: 489 GKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPD 548
G GN A++ Y EA++L+P +N ++ + Q+A E V ++PD
Sbjct: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70
Query: 549 FAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADL 597
+ + L RFE A+++Y +KH P L + A L
Sbjct: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARL 119
Score = 44.3 bits (103), Expect = 4e-04
Identities = 49/232 (21%), Positives = 91/232 (39%), Gaps = 37/232 (15%)
Query: 488 IGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQP 547
+G + K + A+++Y +A L+P + + N + E+ + + EL A+++
Sbjct: 231 LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGR 290
Query: 548 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAW 607
+ + + + E+ Y+ AI +YN + A+ +R D L
Sbjct: 291 ENREDYRQIAKAYARIGNSYFKEEKYKDAIH--------FYN--KSLAE-HRTPDVLKKC 339
Query: 608 RNAT-VLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQ 666
+ A +LK + LA+ N + L+ G E +
Sbjct: 340 QQAEKILKEQERLAYINPDLALEEKNK-------GNECFQ------------------KG 374
Query: 667 KYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPT 718
Y ++ + +AIK NP A + N A Y + LA K E +QL+PT
Sbjct: 375 DYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPT 426
Score = 40.0 bits (92), Expect = 0.008
Identities = 53/220 (24%), Positives = 83/220 (37%), Gaps = 9/220 (4%)
Query: 431 ALSKHTKKKKLIAAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGK 490
AL + K K+L + I N G++ +L A+ V N + + I K
Sbjct: 244 ALKHYDKAKELDPTNMTYIT--NQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIAK 301
Query: 491 NLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLS---LAVQIQP 547
A GN Y++A+ K + A + ++LK+ Q+AE++L I P
Sbjct: 302 AYARIGNSYFKEEKYKDAIHFYNKSL-AEHRTPDVLKK---CQQAEKILKEQERLAYINP 357
Query: 548 DFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAW 607
D A N G + A + Y AIK K Y N Y L AL
Sbjct: 358 DLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDC 417
Query: 608 RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALEL 647
L+P + L+ + +A V ++AL+L
Sbjct: 418 EECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDL 457
Score = 31.6 bits (70), Expect = 2.8
Identities = 25/110 (22%), Positives = 46/110 (41%), Gaps = 2/110 (1%)
Query: 630 NTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPNAASYH 689
+ GN+ A EA++L P++H L + + K Y+++ K + P+ +
Sbjct: 16 SVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGY 75
Query: 690 GNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQKK 739
A + AK+ YE L+ + KE GL + L ++K
Sbjct: 76 SRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKE--GLQNMEARLAERK 123
>gi|189011544 ubiquitously transcribed tetratricopeptide repeat, X
chromosome [Homo sapiens]
Length = 1401
Score = 45.8 bits (107), Expect = 1e-04
Identities = 27/96 (28%), Positives = 49/96 (51%)
Query: 535 AEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLY 594
A + L +++ P+ +W LG +S+ + + A SYR +I D + ++G LY
Sbjct: 269 AIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLY 328
Query: 595 ADLNRHVDALNAWRNATVLKPEHSLAWNNMIILLDN 630
N+ +DAL A+ A L H+ AW ++ L ++
Sbjct: 329 QQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYES 364
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/112 (23%), Positives = 54/112 (48%)
Query: 469 QLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKE 528
Q + +L P + + Y +G+ + G A YR+++ + ++G + ++
Sbjct: 271 QYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQ 330
Query: 529 RNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIKHR 580
+N+ +A + AVQ+ AAAWM+LG + S + + A + Y A + +
Sbjct: 331 QNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNATRSK 382
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/121 (23%), Positives = 56/121 (46%), Gaps = 1/121 (0%)
Query: 492 LADKGNQTA-AIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFA 550
L DK + + AI+Y ++++ +P + LG ++Q+A ++ A
Sbjct: 259 LGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASA 318
Query: 551 AAWMNLGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNA 610
W ++G++ + A Q+Y A++ + + +LG LY N+ DA+ + NA
Sbjct: 319 DTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNA 378
Query: 611 T 611
T
Sbjct: 379 T 379
Score = 30.0 bits (66), Expect = 8.1
Identities = 48/219 (21%), Positives = 88/219 (40%), Gaps = 30/219 (13%)
Query: 522 LGNILKERNELQEAEELLSLAVQIQPDFAAA---WMNLGIV-------QNSLKRFEAA-- 569
LG + N Q A + + + P F A + LG++ ++SLK F+ A
Sbjct: 136 LGLVYFHYNAFQWAIKAFQEVLYVDPSFCRAKEIHLRLGLMFKVNTDYESSLKHFQLALV 195
Query: 570 --------EQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAW 621
+ I H + Y++ Y L + + L+A ATVL+ L W
Sbjct: 196 DCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQ-TENLSAQVKATVLQ---QLGW 251
Query: 622 NNMIILLDNTGNLAQAEAVG----REALELIPNDHSLMFSLANVLGKSQKYKESEALFLK 677
+ + D G+ A E+ +++LE PN + L K +++ + +
Sbjct: 252 MHHTV--DLLGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQ 309
Query: 678 AIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLD 716
+I + +A ++ VLY + A + Y ++QLD
Sbjct: 310 SIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLD 348
>gi|194306559 kinesin light chain 1 isoform 3 [Homo sapiens]
Length = 618
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/188 (26%), Positives = 79/188 (42%), Gaps = 32/188 (17%)
Query: 555 NLGIVQNSLKRFEAAEQSYRTAIKHRRK-----YPDCYYNLGRL---YADLNRHVDALNA 606
NL I S R+E A + A++ K +PD L L Y D N++ DA N
Sbjct: 218 NLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANL 277
Query: 607 WRNATVLK--------PEHSLAWNNMIILLDNTGNLAQAEAVGREALEL----IPNDH-- 652
+A ++ P + NN+ +L G +AE + + ALE+ + DH
Sbjct: 278 LNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
Query: 653 --SLMFSLANVLGKSQKYKESEALFLKAIKA--------NPNAASYHGNLAVLYHRWGHL 702
+ +LA + KY+E E + +A++ +PN A NLA Y + G
Sbjct: 338 VAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKF 397
Query: 703 DLAKKHYE 710
A+ Y+
Sbjct: 398 KQAETLYK 405
Score = 34.3 bits (77), Expect = 0.43
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 9/97 (9%)
Query: 490 KNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQ--- 546
K+ A+ N AIR + + +P +NNL + +R + +EAE L A++I+
Sbjct: 272 KDAANLLNDALAIRE-KTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKV 330
Query: 547 -----PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 578
PD A NL ++ + ++E E Y+ A++
Sbjct: 331 LGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALE 367
>gi|110735431 kinesin light chain 1 isoform 2 [Homo sapiens]
Length = 573
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/188 (26%), Positives = 79/188 (42%), Gaps = 32/188 (17%)
Query: 555 NLGIVQNSLKRFEAAEQSYRTAIKHRRK-----YPDCYYNLGRL---YADLNRHVDALNA 606
NL I S R+E A + A++ K +PD L L Y D N++ DA N
Sbjct: 218 NLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANL 277
Query: 607 WRNATVLK--------PEHSLAWNNMIILLDNTGNLAQAEAVGREALEL----IPNDH-- 652
+A ++ P + NN+ +L G +AE + + ALE+ + DH
Sbjct: 278 LNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
Query: 653 --SLMFSLANVLGKSQKYKESEALFLKAIKA--------NPNAASYHGNLAVLYHRWGHL 702
+ +LA + KY+E E + +A++ +PN A NLA Y + G
Sbjct: 338 VAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKF 397
Query: 703 DLAKKHYE 710
A+ Y+
Sbjct: 398 KQAETLYK 405
Score = 34.3 bits (77), Expect = 0.43
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 9/97 (9%)
Query: 490 KNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQ--- 546
K+ A+ N AIR + + +P +NNL + +R + +EAE L A++I+
Sbjct: 272 KDAANLLNDALAIRE-KTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKV 330
Query: 547 -----PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 578
PD A NL ++ + ++E E Y+ A++
Sbjct: 331 LGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALE 367
>gi|33620730 kinesin light chain 1 isoform 1 [Homo sapiens]
Length = 560
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/188 (26%), Positives = 79/188 (42%), Gaps = 32/188 (17%)
Query: 555 NLGIVQNSLKRFEAAEQSYRTAIKHRRK-----YPDCYYNLGRL---YADLNRHVDALNA 606
NL I S R+E A + A++ K +PD L L Y D N++ DA N
Sbjct: 218 NLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANL 277
Query: 607 WRNATVLK--------PEHSLAWNNMIILLDNTGNLAQAEAVGREALEL----IPNDH-- 652
+A ++ P + NN+ +L G +AE + + ALE+ + DH
Sbjct: 278 LNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPD 337
Query: 653 --SLMFSLANVLGKSQKYKESEALFLKAIKA--------NPNAASYHGNLAVLYHRWGHL 702
+ +LA + KY+E E + +A++ +PN A NLA Y + G
Sbjct: 338 VAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKF 397
Query: 703 DLAKKHYE 710
A+ Y+
Sbjct: 398 KQAETLYK 405
Score = 34.3 bits (77), Expect = 0.43
Identities = 26/97 (26%), Positives = 47/97 (48%), Gaps = 9/97 (9%)
Query: 490 KNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQ--- 546
K+ A+ N AIR + + +P +NNL + +R + +EAE L A++I+
Sbjct: 272 KDAANLLNDALAIRE-KTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKV 330
Query: 547 -----PDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 578
PD A NL ++ + ++E E Y+ A++
Sbjct: 331 LGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALE 367
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.139 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,782,579
Number of Sequences: 37866
Number of extensions: 1136260
Number of successful extensions: 3689
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 64
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 3080
Number of HSP's gapped (non-prelim): 427
length of query: 741
length of database: 18,247,518
effective HSP length: 110
effective length of query: 631
effective length of database: 14,082,258
effective search space: 8885904798
effective search space used: 8885904798
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.