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Search of human proteins with 239754056
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239754056 PREDICTED: ankyrin repeat and death domain
containing 1B [Homo sapiens]
(524 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239754056 PREDICTED: ankyrin repeat and death domain containi... 1041 0.0
gi|239748583 PREDICTED: ankyrin repeat and death domain containi... 1041 0.0
gi|239742602 PREDICTED: ankyrin repeat and death domain containi... 1041 0.0
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 302 6e-82
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 154 1e-37
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 154 1e-37
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 154 1e-37
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 148 1e-35
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 148 1e-35
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 148 1e-35
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 148 1e-35
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 148 1e-35
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 145 9e-35
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 144 3e-34
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 138 1e-32
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 135 9e-32
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 134 2e-31
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 131 2e-30
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 125 7e-29
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 119 5e-27
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 117 3e-26
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 113 5e-25
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 113 5e-25
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 108 1e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 108 1e-23
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 106 5e-23
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 106 5e-23
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 105 1e-22
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 103 4e-22
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 102 7e-22
>gi|239754056 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 524
Score = 1041 bits (2693), Expect = 0.0
Identities = 524/524 (100%), Positives = 524/524 (100%)
Query: 1 MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA
Sbjct: 1 MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
Query: 61 GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL
Sbjct: 61 GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV
Sbjct: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW
Sbjct: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL
Sbjct: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT
Sbjct: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS
Sbjct: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
Query: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH
Sbjct: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
Query: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI
Sbjct: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
>gi|239748583 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 524
Score = 1041 bits (2693), Expect = 0.0
Identities = 524/524 (100%), Positives = 524/524 (100%)
Query: 1 MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA
Sbjct: 1 MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
Query: 61 GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL
Sbjct: 61 GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV
Sbjct: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW
Sbjct: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL
Sbjct: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT
Sbjct: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS
Sbjct: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
Query: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH
Sbjct: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
Query: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI
Sbjct: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
>gi|239742602 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 607
Score = 1041 bits (2693), Expect = 0.0
Identities = 524/524 (100%), Positives = 524/524 (100%)
Query: 1 MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA
Sbjct: 1 MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
Query: 61 GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL
Sbjct: 61 GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV
Sbjct: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW
Sbjct: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL
Sbjct: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT
Sbjct: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS
Sbjct: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
Query: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH
Sbjct: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
Query: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI
Sbjct: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 302 bits (773), Expect = 6e-82
Identities = 182/474 (38%), Positives = 267/474 (56%), Gaps = 34/474 (7%)
Query: 65 LLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHK 124
LLP ER AA+ NN+ M++L ++VN N++ R ALH+A G H AV LL+H+
Sbjct: 12 LLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHE 71
Query: 125 ARVDVADK----------HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFA 174
A VD D G+ + L+AW G L ++ +LV +GA +++DG++ LH A
Sbjct: 72 AAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCA 131
Query: 175 TQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKI 234
Q HV ++ ++++DL L+ D+ GR F AAE G ++ ++ L + KDK
Sbjct: 132 AQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE 191
Query: 235 QWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSP 294
+ L AA R +A L + G + + G TALH AA H
Sbjct: 192 GNTALHLAA------GRGHMAVL--QRLVDIGLDLEEQNAE----GLTALHSAAGGSHPD 239
Query: 295 AVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE----NVDLHQKVEPKESPL 350
VQ+LL +N + + N+S L A +G + L+ NV HQ SPL
Sbjct: 240 CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA----SPL 295
Query: 351 HLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDK 410
HL V +N +V L+++ D++ ++ +QQTPLH+AA+ ++ + LL AG DL DK
Sbjct: 296 HLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 355
Query: 411 QGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHI 470
QGKTALAVA RSNH +V M+IKA+R+Y W ++H DPS G +L+FKQDH ET+ +
Sbjct: 356 QGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPS---DPS-GKSLSFKQDHRQETQQL 411
Query: 471 RTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
R++LW LA L+ EW++LA SW FT+ + AIE+QW+G S++EHGHR LLI
Sbjct: 412 RSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLI 465
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 154 bits (390), Expect = 1e-37
Identities = 112/392 (28%), Positives = 187/392 (47%), Gaps = 35/392 (8%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA++ NLD + + + ++IN N ALH A H+ V LL + VD A
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+A+ +G EV+ +LVK GA+ A++Q+G + L+ A Q NH+ +V+YL++
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE-- 130
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
+ + + E G P +A ++GH + + L L K K++ L AA
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKS 186
Query: 244 -------------LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG---------GN 281
+KM +R + + T + V+ +++ L +G G
Sbjct: 187 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 246
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T LH+A+K G++ V++LL + I+ ++ L A R+GH +V LL L
Sbjct: 247 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + SPLH+ +H+ V LL + +D + T LHVAA G+ + + LL
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ A G T L +A + N V+ +L+K
Sbjct: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVK 398
Score = 139 bits (351), Expect = 5e-33
Identities = 105/394 (26%), Positives = 177/394 (44%), Gaps = 29/394 (7%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N + +ME L + +I + T +H A HL+ V L
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L++ A DV + G T +H+AA +G +EV+ L++ GA A+ ++ + LH A++
Sbjct: 430 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 489
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
IV+ L+Q H+ + G P ++A G V++ L S K ++ L
Sbjct: 490 EIVQLLLQ--HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 547
Query: 241 TAA------LTKMKTSRNSIAALTIEGACSP---GTGVSTSSVSLL------------QG 279
AA + K+ R + A + +P V+LL +
Sbjct: 548 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 607
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
G T LH+AAK LL + N + + ++ L +A++ GH +V LL + ++
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Query: 340 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
H + + LHL + + V + L D D + TPL VA GNV++V LL
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727
Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
K G ++ A K G T L A++ H+ ++ +L++
Sbjct: 728 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761
Score = 132 bits (331), Expect = 1e-30
Identities = 89/359 (24%), Positives = 173/359 (48%), Gaps = 14/359 (3%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + + + L +K+ N N T LH A +N + ++ L+K+ A + + G
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
LT IH+AA+ G L ++L+L++ GA N G +ALH A ++ V +V L+++ L D
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+E + P +A+ G E+++ L H ++ L +A + + +
Sbjct: 471 ARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA----REGQVDV 524
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
A++ +E + + G T LH+AAK+G ++LL + + + +
Sbjct: 525 ASVLLEAGAAHSLAT--------KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 576
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
+ L +A + + LL + H + +PLH+ N + + ++LL+ + +I
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ ++ TPLH+A+ G+ ++V LL G ++ K G T+L +A++ + V +L K
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695
Score = 113 bits (283), Expect = 4e-25
Identities = 86/345 (24%), Positives = 150/345 (43%), Gaps = 47/345 (13%)
Query: 89 EKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE 148
+ K+ +N T LH A +++ LL A VD ++G+T +H+A+ G+
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259
Query: 149 VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLL 208
++ +L+ G AK +DG++ LH A +S H ++VE L++ L + G P +
Sbjct: 260 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGAPLLARTKNGLSPLHM 317
Query: 209 AAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG 268
AA+ HVE ++ L H + D + L
Sbjct: 318 AAQGDHVECVKHLL---QHKAPVDDVTLDYL----------------------------- 345
Query: 269 VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASL 328
TALH+AA GH ++LL + + N + L IA + +
Sbjct: 346 -------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392
Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
+ L+ + E +P+H+ H+ +V LL D+ N + +T LH+AA
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452
Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
G VE+V LL+ G + A ++ +T L +ASR + +V +L++
Sbjct: 453 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497
Score = 106 bits (265), Expect = 5e-23
Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 56/415 (13%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AAK ++ L+++L + +++ TALH A V L+K A ++ ++G
Sbjct: 50 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
T +++AA ++V+ L++ GA+Q +DG + L A Q H + V L+++
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169
Query: 190 -----LHL---KD----------------------LNQPDEKGRKPFLLAAERGHVEMIE 219
LH+ KD +N+ E G P +AA G+V +
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229
Query: 220 KLTFLNLHTSEKDKIQWSTLWTAA------LTKMKTSRNS-IAALTIEGA----CSPGTG 268
L + + L A+ + K+ R I A T +G C+ +G
Sbjct: 230 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 289
Query: 269 VSTSSVSLLQ----------GGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
LL+ G + LH+AA+ H V+ LL ++++ +++L
Sbjct: 290 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 349
Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
+A GH + LL + + + + +PLH+ N I V+ L+ I + +
Sbjct: 350 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 409
Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
TP+HVAA G++ +V LL+ G + +G+TAL +A+R+ VV L++
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 464
Score = 74.3 bits (181), Expect = 2e-13
Identities = 49/190 (25%), Positives = 90/190 (47%), Gaps = 2/190 (1%)
Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
N + AA+ G+ V L DIN N+ +++L +A + GH LV LL +
Sbjct: 11 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70
Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
+ + LH+ + VV L+ +I+ +Q TPL++AA ++++V+ LL+
Sbjct: 71 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130
Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWR--EEHHESIRDPSTGFTLT 458
G + + G T LAVA + H+ V +L++ + R H + +D + L
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 190
Query: 459 FKQDHSLETR 468
+ DH+ + +
Sbjct: 191 LQNDHNADVQ 200
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 154 bits (390), Expect = 1e-37
Identities = 112/392 (28%), Positives = 187/392 (47%), Gaps = 35/392 (8%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA++ NLD + + + ++IN N ALH A H+ V LL + VD A
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+A+ +G EV+ +LVK GA+ A++Q+G + L+ A Q NH+ +V+YL++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE-- 151
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
+ + + E G P +A ++GH + + L L K K++ L AA
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKS 207
Query: 244 -------------LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG---------GN 281
+KM +R + + T + V+ +++ L +G G
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T LH+A+K G++ V++LL + I+ ++ L A R+GH +V LL L
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + SPLH+ +H+ V LL + +D + T LHVAA G+ + + LL
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ A G T L +A + N V+ +L+K
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVK 419
Score = 139 bits (351), Expect = 5e-33
Identities = 105/394 (26%), Positives = 177/394 (44%), Gaps = 29/394 (7%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N + +ME L + +I + T +H A HL+ V L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L++ A DV + G T +H+AA +G +EV+ L++ GA A+ ++ + LH A++
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
IV+ L+Q H+ + G P ++A G V++ L S K ++ L
Sbjct: 511 EIVQLLLQ--HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 241 TAA------LTKMKTSRNSIAALTIEGACSP---GTGVSTSSVSLL------------QG 279
AA + K+ R + A + +P V+LL +
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
G T LH+AAK LL + N + + ++ L +A++ GH +V LL + ++
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 340 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
H + + LHL + + V + L D D + TPL VA GNV++V LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
K G ++ A K G T L A++ H+ ++ +L++
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Score = 132 bits (331), Expect = 1e-30
Identities = 89/359 (24%), Positives = 173/359 (48%), Gaps = 14/359 (3%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + + + L +K+ N N T LH A +N + ++ L+K+ A + + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
LT IH+AA+ G L ++L+L++ GA N G +ALH A ++ V +V L+++ L D
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+E + P +A+ G E+++ L H ++ L +A + + +
Sbjct: 492 ARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA----REGQVDV 545
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
A++ +E + + G T LH+AAK+G ++LL + + + +
Sbjct: 546 ASVLLEAGAAHSLAT--------KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
+ L +A + + LL + H + +PLH+ N + + ++LL+ + +I
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ ++ TPLH+A+ G+ ++V LL G ++ K G T+L +A++ + V +L K
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Score = 113 bits (283), Expect = 4e-25
Identities = 86/345 (24%), Positives = 150/345 (43%), Gaps = 47/345 (13%)
Query: 89 EKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE 148
+ K+ +N T LH A +++ LL A VD ++G+T +H+A+ G+
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 149 VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLL 208
++ +L+ G AK +DG++ LH A +S H ++VE L++ L + G P +
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGAPLLARTKNGLSPLHM 338
Query: 209 AAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG 268
AA+ HVE ++ L H + D + L
Sbjct: 339 AAQGDHVECVKHLL---QHKAPVDDVTLDYL----------------------------- 366
Query: 269 VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASL 328
TALH+AA GH ++LL + + N + L IA + +
Sbjct: 367 -------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
+ L+ + E +P+H+ H+ +V LL D+ N + +T LH+AA
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
G VE+V LL+ G + A ++ +T L +ASR + +V +L++
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Score = 106 bits (265), Expect = 5e-23
Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 56/415 (13%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AAK ++ L+++L + +++ TALH A V L+K A ++ ++G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
T +++AA ++V+ L++ GA+Q +DG + L A Q H + V L+++
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 190 -----LHL---KD----------------------LNQPDEKGRKPFLLAAERGHVEMIE 219
LH+ KD +N+ E G P +AA G+V +
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 220 KLTFLNLHTSEKDKIQWSTLWTAA------LTKMKTSRNS-IAALTIEGA----CSPGTG 268
L + + L A+ + K+ R I A T +G C+ +G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
Query: 269 VSTSSVSLLQ----------GGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
LL+ G + LH+AA+ H V+ LL ++++ +++L
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
+A GH + LL + + + + +PLH+ N I V+ L+ I + +
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430
Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
TP+HVAA G++ +V LL+ G + +G+TAL +A+R+ VV L++
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Score = 74.3 bits (181), Expect = 2e-13
Identities = 49/190 (25%), Positives = 90/190 (47%), Gaps = 2/190 (1%)
Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
N + AA+ G+ V L DIN N+ +++L +A + GH LV LL +
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
+ + LH+ + VV L+ +I+ +Q TPL++AA ++++V+ LL+
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWR--EEHHESIRDPSTGFTLT 458
G + + G T LAVA + H+ V +L++ + R H + +D + L
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211
Query: 459 FKQDHSLETR 468
+ DH+ + +
Sbjct: 212 LQNDHNADVQ 221
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 154 bits (390), Expect = 1e-37
Identities = 112/392 (28%), Positives = 187/392 (47%), Gaps = 35/392 (8%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA++ NLD + + + ++IN N ALH A H+ V LL + VD A
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+A+ +G EV+ +LVK GA+ A++Q+G + L+ A Q NH+ +V+YL++
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE-- 151
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
+ + + E G P +A ++GH + + L L K K++ L AA
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKS 207
Query: 244 -------------LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG---------GN 281
+KM +R + + T + V+ +++ L +G G
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T LH+A+K G++ V++LL + I+ ++ L A R+GH +V LL L
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + SPLH+ +H+ V LL + +D + T LHVAA G+ + + LL
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ A G T L +A + N V+ +L+K
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVK 419
Score = 139 bits (351), Expect = 5e-33
Identities = 105/394 (26%), Positives = 177/394 (44%), Gaps = 29/394 (7%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N + +ME L + +I + T +H A HL+ V L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L++ A DV + G T +H+AA +G +EV+ L++ GA A+ ++ + LH A++
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
IV+ L+Q H+ + G P ++A G V++ L S K ++ L
Sbjct: 511 EIVQLLLQ--HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568
Query: 241 TAA------LTKMKTSRNSIAALTIEGACSP---GTGVSTSSVSLL------------QG 279
AA + K+ R + A + +P V+LL +
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
G T LH+AAK LL + N + + ++ L +A++ GH +V LL + ++
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 340 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
H + + LHL + + V + L D D + TPL VA GNV++V LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
K G ++ A K G T L A++ H+ ++ +L++
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Score = 132 bits (331), Expect = 1e-30
Identities = 89/359 (24%), Positives = 173/359 (48%), Gaps = 14/359 (3%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + + + L +K+ N N T LH A +N + ++ L+K+ A + + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
LT IH+AA+ G L ++L+L++ GA N G +ALH A ++ V +V L+++ L D
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+E + P +A+ G E+++ L H ++ L +A + + +
Sbjct: 492 ARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA----REGQVDV 545
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
A++ +E + + G T LH+AAK+G ++LL + + + +
Sbjct: 546 ASVLLEAGAAHSLAT--------KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
+ L +A + + LL + H + +PLH+ N + + ++LL+ + +I
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ ++ TPLH+A+ G+ ++V LL G ++ K G T+L +A++ + V +L K
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716
Score = 113 bits (283), Expect = 4e-25
Identities = 86/345 (24%), Positives = 150/345 (43%), Gaps = 47/345 (13%)
Query: 89 EKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE 148
+ K+ +N T LH A +++ LL A VD ++G+T +H+A+ G+
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 149 VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLL 208
++ +L+ G AK +DG++ LH A +S H ++VE L++ L + G P +
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGAPLLARTKNGLSPLHM 338
Query: 209 AAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG 268
AA+ HVE ++ L H + D + L
Sbjct: 339 AAQGDHVECVKHLL---QHKAPVDDVTLDYL----------------------------- 366
Query: 269 VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASL 328
TALH+AA GH ++LL + + N + L IA + +
Sbjct: 367 -------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413
Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
+ L+ + E +P+H+ H+ +V LL D+ N + +T LH+AA
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
G VE+V LL+ G + A ++ +T L +ASR + +V +L++
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Score = 106 bits (265), Expect = 5e-23
Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 56/415 (13%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AAK ++ L+++L + +++ TALH A V L+K A ++ ++G
Sbjct: 71 AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
T +++AA ++V+ L++ GA+Q +DG + L A Q H + V L+++
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 190 -----LHL---KD----------------------LNQPDEKGRKPFLLAAERGHVEMIE 219
LH+ KD +N+ E G P +AA G+V +
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250
Query: 220 KLTFLNLHTSEKDKIQWSTLWTAA------LTKMKTSRNS-IAALTIEGA----CSPGTG 268
L + + L A+ + K+ R I A T +G C+ +G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310
Query: 269 VSTSSVSLLQ----------GGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
LL+ G + LH+AA+ H V+ LL ++++ +++L
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370
Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
+A GH + LL + + + + +PLH+ N I V+ L+ I + +
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430
Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
TP+HVAA G++ +V LL+ G + +G+TAL +A+R+ VV L++
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485
Score = 74.3 bits (181), Expect = 2e-13
Identities = 49/190 (25%), Positives = 90/190 (47%), Gaps = 2/190 (1%)
Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
N + AA+ G+ V L DIN N+ +++L +A + GH LV LL +
Sbjct: 32 NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91
Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
+ + LH+ + VV L+ +I+ +Q TPL++AA ++++V+ LL+
Sbjct: 92 SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151
Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWR--EEHHESIRDPSTGFTLT 458
G + + G T LAVA + H+ V +L++ + R H + +D + L
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211
Query: 459 FKQDHSLETR 468
+ DH+ + +
Sbjct: 212 LQNDHNADVQ 221
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 148 bits (374), Expect = 1e-35
Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA+S NLD V+IN N LH A H+ V LL + ++
Sbjct: 48 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+AA +G EV+ LV GA+ A++Q G + L+ A Q NH+ +V++L++
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 165
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
+ + N E G P +A ++GH ++ L ++ K K++ L AA +
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 217
Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
AA+ ++ +P T L Q G T LH
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
+A++ G+ V++LL + I + ++ L A RNGH + LL + K +
Sbjct: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
SP+H+ +H+ V LL +ID + TPLHVAA G+ + + LL G
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 397
Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ G T L +A + NH V+ +L+K
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLK 425
Score = 135 bits (340), Expect = 9e-32
Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N++ +ME L + +I+ V T LH A HL V L
Sbjct: 397 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L+ A +V++ T +H+AA +G EV L++ A AK +D + LH A + H
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
+V+ L+++ + N G P +AA GHVE + L + K ++ L
Sbjct: 517 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 574
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
AA K + +A L +E P G++ V+ L +GG+
Sbjct: 575 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630
Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
T LH+AAK + LL N + ++ L +A + GHA +V LLS+
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690
Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
+ + + +PLHLV H+ V + L+ +D + TPLHVA+ GN++LV
Sbjct: 691 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 750
Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ LL+ D+ A K G + L A++ H+ +V +L+K
Sbjct: 751 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 788
Score = 132 bits (333), Expect = 6e-31
Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA NL++ + L + ++N T LH A R ++ V LL A+++ K
Sbjct: 246 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
LT +H AA +G + + +L+ GA +AK ++G+S +H A Q +H+ V L+Q D +
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
D+ P +AA GH + + L L K + +T K +
Sbjct: 366 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 418
Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
+ L ++ TG S +V+ + G T LH+A+ GH P V+ LL + N N
Sbjct: 419 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
+ L +A R GH + +LL ++ K + ++PLH H +V LL + +
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ TPLH+AA G+VE V LL+ + K+G T L VA++ V +L++
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590
Query: 434 AERY 437
+ +
Sbjct: 591 RDAH 594
Score = 132 bits (333), Expect = 6e-31
Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E AA++ + ++ + L + K +N ++T LH A H + V LL++ A +
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+A G T +H+AA G +E +L L++ A Q + G + LH A + VR+ E L++
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590
Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
D H N + G P +A ++++++ L + S W T +
Sbjct: 591 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 639
Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
+ G + SV G T LHLAA+ GH+ V +LL++ + N
Sbjct: 640 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 695
Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
N+ ++ L + + GH + + L+ V + +PLH+ +I +V LL
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
Q D++ + +PLH AA +G+ ++V LLK G V G T LA+A R + V
Sbjct: 756 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815
Query: 428 VGML 431
+L
Sbjct: 816 TDVL 819
Score = 125 bits (315), Expect = 7e-29
Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ ++LD + L + I+ + + T LH A H LL A+ + +G
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+A + VM +L+K GA A + G++ LH A+ H+ IV+ L+Q
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 462
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
N + K P +AA GH E+ + L + K K + L AA + ++
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 518
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
L +E +P + G+T LH+AA+ GH V LL + M +
Sbjct: 519 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 570
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
+ L +A + G + LL D H K +PLH+ V +N++ +V LL
Sbjct: 571 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628
Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
TPLH+AA + VE+ +LL+ G A QG T L +A++ H+ +V +L+
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Query: 433 KAE 435
+
Sbjct: 689 SKQ 691
Score = 73.2 bits (178), Expect = 6e-13
Identities = 45/151 (29%), Positives = 77/151 (50%)
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T+ AA+ G+ L DIN N+ ++ L +A++ GH +V LL + + L
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + LH+ + VV L++ +++ +QK TPL++AA ++E+V+ LL+
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
G + + G T LAVA + H VV LI
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLI 197
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 148 bits (374), Expect = 1e-35
Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA+S NLD V+IN N LH A H+ V LL + ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+AA +G EV+ LV GA+ A++Q G + L+ A Q NH+ +V++L++
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
+ + N E G P +A ++GH ++ L ++ K K++ L AA +
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184
Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
AA+ ++ +P T L Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
+A++ G+ V++LL + I + ++ L A RNGH + LL + K +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
SP+H+ +H+ V LL +ID + TPLHVAA G+ + + LL G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ G T L +A + NH V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 135 bits (340), Expect = 9e-32
Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N++ +ME L + +I+ V T LH A HL V L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L+ A +V++ T +H+AA +G EV L++ A AK +D + LH A + H
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
+V+ L+++ + N G P +AA GHVE + L + K ++ L
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
AA K + +A L +E P G++ V+ L +GG+
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
T LH+AAK + LL N + ++ L +A + GHA +V LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
+ + + +PLHLV H+ V + L+ +D + TPLHVA+ GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ LL+ D+ A K G + L A++ H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 132 bits (333), Expect = 6e-31
Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA NL++ + L + ++N T LH A R ++ V LL A+++ K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
LT +H AA +G + + +L+ GA +AK ++G+S +H A Q +H+ V L+Q D +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
D+ P +AA GH + + L L K + +T K +
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
+ L ++ TG S +V+ + G T LH+A+ GH P V+ LL + N N
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
+ L +A R GH + +LL ++ K + ++PLH H +V LL + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ TPLH+AA G+VE V LL+ + K+G T L VA++ V +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 434 AERY 437
+ +
Sbjct: 558 RDAH 561
Score = 132 bits (333), Expect = 6e-31
Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E AA++ + ++ + L + K +N ++T LH A H + V LL++ A +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+A G T +H+AA G +E +L L++ A Q + G + LH A + VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
D H N + G P +A ++++++ L + S W T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606
Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
+ G + SV G T LHLAA+ GH+ V +LL++ + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
N+ ++ L + + GH + + L+ V + +PLH+ +I +V LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
Q D++ + +PLH AA +G+ ++V LLK G V G T LA+A R + V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 428 VGML 431
+L
Sbjct: 783 TDVL 786
Score = 125 bits (315), Expect = 7e-29
Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ ++LD + L + I+ + + T LH A H LL A+ + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+A + VM +L+K GA A + G++ LH A+ H+ IV+ L+Q
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
N + K P +AA GH E+ + L + K K + L AA + ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
L +E +P + G+T LH+AA+ GH V LL + M +
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
+ L +A + G + LL D H K +PLH+ V +N++ +V LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
TPLH+AA + VE+ +LL+ G A QG T L +A++ H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 433 KAE 435
+
Sbjct: 656 SKQ 658
Score = 73.2 bits (178), Expect = 6e-13
Identities = 45/151 (29%), Positives = 77/151 (50%)
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T+ AA+ G+ L DIN N+ ++ L +A++ GH +V LL + + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + LH+ + VV L++ +++ +QK TPL++AA ++E+V+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
G + + G T LAVA + H VV LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 148 bits (374), Expect = 1e-35
Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA+S NLD V+IN N LH A H+ V LL + ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+AA +G EV+ LV GA+ A++Q G + L+ A Q NH+ +V++L++
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
+ + N E G P +A ++GH ++ L ++ K K++ L AA +
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184
Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
AA+ ++ +P T L Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
+A++ G+ V++LL + I + ++ L A RNGH + LL + K +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
SP+H+ +H+ V LL +ID + TPLHVAA G+ + + LL G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ G T L +A + NH V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 135 bits (340), Expect = 9e-32
Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N++ +ME L + +I+ V T LH A HL V L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L+ A +V++ T +H+AA +G EV L++ A AK +D + LH A + H
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
+V+ L+++ + N G P +AA GHVE + L + K ++ L
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
AA K + +A L +E P G++ V+ L +GG+
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
T LH+AAK + LL N + ++ L +A + GHA +V LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
+ + + +PLHLV H+ V + L+ +D + TPLHVA+ GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ LL+ D+ A K G + L A++ H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 132 bits (333), Expect = 6e-31
Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA NL++ + L + ++N T LH A R ++ V LL A+++ K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
LT +H AA +G + + +L+ GA +AK ++G+S +H A Q +H+ V L+Q D +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
D+ P +AA GH + + L L K + +T K +
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
+ L ++ TG S +V+ + G T LH+A+ GH P V+ LL + N N
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
+ L +A R GH + +LL ++ K + ++PLH H +V LL + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ TPLH+AA G+VE V LL+ + K+G T L VA++ V +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 434 AERY 437
+ +
Sbjct: 558 RDAH 561
Score = 132 bits (333), Expect = 6e-31
Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E AA++ + ++ + L + K +N ++T LH A H + V LL++ A +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+A G T +H+AA G +E +L L++ A Q + G + LH A + VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
D H N + G P +A ++++++ L + S W T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606
Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
+ G + SV G T LHLAA+ GH+ V +LL++ + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
N+ ++ L + + GH + + L+ V + +PLH+ +I +V LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
Q D++ + +PLH AA +G+ ++V LLK G V G T LA+A R + V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 428 VGML 431
+L
Sbjct: 783 TDVL 786
Score = 125 bits (315), Expect = 7e-29
Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ ++LD + L + I+ + + T LH A H LL A+ + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+A + VM +L+K GA A + G++ LH A+ H+ IV+ L+Q
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
N + K P +AA GH E+ + L + K K + L AA + ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
L +E +P + G+T LH+AA+ GH V LL + M +
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
+ L +A + G + LL D H K +PLH+ V +N++ +V LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
TPLH+AA + VE+ +LL+ G A QG T L +A++ H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 433 KAE 435
+
Sbjct: 656 SKQ 658
Score = 73.2 bits (178), Expect = 6e-13
Identities = 45/151 (29%), Positives = 77/151 (50%)
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T+ AA+ G+ L DIN N+ ++ L +A++ GH +V LL + + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + LH+ + VV L++ +++ +QK TPL++AA ++E+V+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
G + + G T LAVA + H VV LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 148 bits (374), Expect = 1e-35
Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA+S NLD V+IN N LH A H+ V LL + ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+AA +G EV+ LV GA+ A++Q G + L+ A Q NH+ +V++L++
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
+ + N E G P +A ++GH ++ L ++ K K++ L AA +
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184
Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
AA+ ++ +P T L Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
+A++ G+ V++LL + I + ++ L A RNGH + LL + K +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
SP+H+ +H+ V LL +ID + TPLHVAA G+ + + LL G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ G T L +A + NH V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 135 bits (340), Expect = 9e-32
Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N++ +ME L + +I+ V T LH A HL V L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L+ A +V++ T +H+AA +G EV L++ A AK +D + LH A + H
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
+V+ L+++ + N G P +AA GHVE + L + K ++ L
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
AA K + +A L +E P G++ V+ L +GG+
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
T LH+AAK + LL N + ++ L +A + GHA +V LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
+ + + +PLHLV H+ V + L+ +D + TPLHVA+ GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ LL+ D+ A K G + L A++ H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 132 bits (333), Expect = 6e-31
Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA NL++ + L + ++N T LH A R ++ V LL A+++ K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
LT +H AA +G + + +L+ GA +AK ++G+S +H A Q +H+ V L+Q D +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
D+ P +AA GH + + L L K + +T K +
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
+ L ++ TG S +V+ + G T LH+A+ GH P V+ LL + N N
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
+ L +A R GH + +LL ++ K + ++PLH H +V LL + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ TPLH+AA G+VE V LL+ + K+G T L VA++ V +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 434 AERY 437
+ +
Sbjct: 558 RDAH 561
Score = 132 bits (333), Expect = 6e-31
Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E AA++ + ++ + L + K +N ++T LH A H + V LL++ A +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+A G T +H+AA G +E +L L++ A Q + G + LH A + VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
D H N + G P +A ++++++ L + S W T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606
Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
+ G + SV G T LHLAA+ GH+ V +LL++ + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
N+ ++ L + + GH + + L+ V + +PLH+ +I +V LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
Q D++ + +PLH AA +G+ ++V LLK G V G T LA+A R + V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 428 VGML 431
+L
Sbjct: 783 TDVL 786
Score = 125 bits (315), Expect = 7e-29
Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ ++LD + L + I+ + + T LH A H LL A+ + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+A + VM +L+K GA A + G++ LH A+ H+ IV+ L+Q
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
N + K P +AA GH E+ + L + K K + L AA + ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
L +E +P + G+T LH+AA+ GH V LL + M +
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
+ L +A + G + LL D H K +PLH+ V +N++ +V LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
TPLH+AA + VE+ +LL+ G A QG T L +A++ H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 433 KAE 435
+
Sbjct: 656 SKQ 658
Score = 73.2 bits (178), Expect = 6e-13
Identities = 45/151 (29%), Positives = 77/151 (50%)
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T+ AA+ G+ L DIN N+ ++ L +A++ GH +V LL + + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + LH+ + VV L++ +++ +QK TPL++AA ++E+V+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
G + + G T LAVA + H VV LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 148 bits (374), Expect = 1e-35
Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
SF AA+S NLD V+IN N LH A H+ V LL + ++
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+AA +G EV+ LV GA+ A++Q G + L+ A Q NH+ +V++L++
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
+ + N E G P +A ++GH ++ L ++ K K++ L AA +
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184
Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
AA+ ++ +P T L Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
+A++ G+ V++LL + I + ++ L A RNGH + LL + K +
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
SP+H+ +H+ V LL +ID + TPLHVAA G+ + + LL G
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364
Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ G T L +A + NH V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 135 bits (340), Expect = 9e-32
Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)
Query: 67 PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
PN R+ A K N++ +ME L + +I+ V T LH A HL V L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423
Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
L+ A +V++ T +H+AA +G EV L++ A AK +D + LH A + H
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
+V+ L+++ + N G P +AA GHVE + L + K ++ L
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
AA K + +A L +E P G++ V+ L +GG+
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597
Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
T LH+AAK + LL N + ++ L +A + GHA +V LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657
Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
+ + + +PLHLV H+ V + L+ +D + TPLHVA+ GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ LL+ D+ A K G + L A++ H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 132 bits (333), Expect = 6e-31
Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA NL++ + L + ++N T LH A R ++ V LL A+++ K
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
LT +H AA +G + + +L+ GA +AK ++G+S +H A Q +H+ V L+Q D +
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
D+ P +AA GH + + L L K + +T K +
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385
Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
+ L ++ TG S +V+ + G T LH+A+ GH P V+ LL + N N
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
+ L +A R GH + +LL ++ K + ++PLH H +V LL + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ TPLH+AA G+VE V LL+ + K+G T L VA++ V +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 434 AERY 437
+ +
Sbjct: 558 RDAH 561
Score = 132 bits (333), Expect = 6e-31
Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E AA++ + ++ + L + K +N ++T LH A H + V LL++ A +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+A G T +H+AA G +E +L L++ A Q + G + LH A + VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
D H N + G P +A ++++++ L + S W T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606
Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
+ G + SV G T LHLAA+ GH+ V +LL++ + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
N+ ++ L + + GH + + L+ V + +PLH+ +I +V LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
Q D++ + +PLH AA +G+ ++V LLK G V G T LA+A R + V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782
Query: 428 VGML 431
+L
Sbjct: 783 TDVL 786
Score = 125 bits (315), Expect = 7e-29
Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ ++LD + L + I+ + + T LH A H LL A+ + +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+A + VM +L+K GA A + G++ LH A+ H+ IV+ L+Q
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
N + K P +AA GH E+ + L + K K + L AA + ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
L +E +P + G+T LH+AA+ GH V LL + M +
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
+ L +A + G + LL D H K +PLH+ V +N++ +V LL
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595
Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
TPLH+AA + VE+ +LL+ G A QG T L +A++ H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 433 KAE 435
+
Sbjct: 656 SKQ 658
Score = 73.2 bits (178), Expect = 6e-13
Identities = 45/151 (29%), Positives = 77/151 (50%)
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T+ AA+ G+ L DIN N+ ++ L +A++ GH +V LL + + L
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ + LH+ + VV L++ +++ +QK TPL++AA ++E+V+ LL+
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
G + + G T LAVA + H VV LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 145 bits (366), Expect = 9e-35
Identities = 108/384 (28%), Positives = 183/384 (47%), Gaps = 27/384 (7%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
S+ AA++ +L+ + V+IN+ N ALH A H+ V LL+ +A VD A
Sbjct: 44 SYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
K G T +H+A+ +G EV+ +LV GA+ A++Q+G + L+ A Q NH+ +V++L+ +
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAAL---TKM 247
+ L E G P +A ++GH +++ L L K K++ L AA TK
Sbjct: 164 ASQSL--ATEDGFTPLAVALQQGHDQVVSLL----LENDTKGKVRLPALHIAARKDDTKA 217
Query: 248 KT------------SRNSIAALTIE---GACSPGTGVSTSSVSL---LQGGNTALHLAAK 289
S++ L I G + T + + ++ + T LH+A+K
Sbjct: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277
Query: 290 HGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESP 349
G++ V++LL + I+ ++ L R+GH +V LL + K + SP
Sbjct: 278 RGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSP 337
Query: 350 LHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVD 409
LH+ +H+ V LL +D + T LHVAA G+ ++ + LL + A
Sbjct: 338 LHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397
Query: 410 KQGKTALAVASRSNHSLVVGMLIK 433
G T L +A + N V+ +L+K
Sbjct: 398 LNGFTPLHIACKKNRIKVMELLLK 421
Score = 143 bits (360), Expect = 4e-34
Identities = 108/415 (26%), Positives = 173/415 (41%), Gaps = 60/415 (14%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + + + L +KK N N T LH A +N + ++ LLKH A + + G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
LT IH+AA+ G + ++ L+ GA N G +ALH A +S +V YL+QD
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 190 ---------LHLK-----------------DLNQPDEKGRKPFLLAAERGHVEMIEKLTF 223
LH+ N G P L+A GH ++ L
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 553
Query: 224 LNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG-------------VS 270
S K ++ L AA K + +A L ++ + SP
Sbjct: 554 HGASLSITTKKGFTPLHVAA----KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD 609
Query: 271 TSSVSLL------------QGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
V+LL + G T LH+AAK LL D N + I+S+
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669
Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
+A + GH +V+ LL N +++ + +PLHL + + V L++ +D +
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
TPLHV GN+++V LL+ + A K G T L A++ H+ ++ +L++
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 784
Score = 127 bits (319), Expect = 2e-29
Identities = 124/512 (24%), Positives = 201/512 (39%), Gaps = 85/512 (16%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
A K N + +ME L + +I V T +H A H++ V L+ H A + + G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+AA SG EV+ LV+ GA AK +D + LH + + IV+ L+Q
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG--AS 524
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
N G P L+A GH ++ L S K ++ L AA K + +
Sbjct: 525 PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA----KYGKLEV 580
Query: 255 AALTIEGACSPGTG-------------VSTSSVSLL------------QGGNTALHLAAK 289
A L ++ + SP V+LL + G T LH+AAK
Sbjct: 581 ANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640
Query: 290 HGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESP 349
LL D N + I+S+ +A + GH +V+ LL N +++ + +P
Sbjct: 641 KNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP 700
Query: 350 LHL-----------VVINN----------------------HITVVNSLLSAQHDIDILN 376
LHL V++N +I +VN LL ++
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 760
Query: 377 QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAER 436
+ TPLH AA +G+ ++ LL+ + G TAL +A R + VV L
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL----- 815
Query: 437 YYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQL-KANEWQRLARSWN 495
I T T T + H + + D++ ++ KAN + L+
Sbjct: 816 ----------KIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEY 865
Query: 496 FTD-----DQIRAIEEQWSGNESFREHGHRAL 522
+D D + +++ G + +E G +L
Sbjct: 866 ISDVEEGEDAMTGDTDKYLGPQDLKELGDDSL 897
Score = 106 bits (265), Expect = 5e-23
Identities = 81/359 (22%), Positives = 151/359 (42%), Gaps = 47/359 (13%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ ++ L + N +V + T LH A +++ LL A VD ++
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
+T +H+A+ G+ ++ +L+ GA AK +DG++ LH +S H ++VE L+
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD--RAAP 326
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+ + G P +A + H+ ++ L N+
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV---------------------------- 358
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
P V+ + TALH+AA GH +VLL + + N
Sbjct: 359 ----------PVDDVTNDYL-------TALHVAAHCGHYKVAKVLLDKKANPNAKALNGF 401
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
+ L IA + ++ LL + E +P+H+ H+ +V+ L+ +
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
N + +T LH+AA G E+V L++ G ++A K +T L +++R + +V L++
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
Score = 72.4 bits (176), Expect = 9e-13
Identities = 42/153 (27%), Positives = 77/153 (50%)
Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
N + AA+ GH + DIN N+ +++L +A++ GH +V+ LL ++
Sbjct: 42 NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVD 101
Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
+ + LH+ + VV L++ +++ +Q TPL++AA ++E+V+ LL
Sbjct: 102 AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
G + G T LAVA + H VV +L++
Sbjct: 162 NGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 144 bits (362), Expect = 3e-34
Identities = 105/346 (30%), Positives = 164/346 (47%), Gaps = 13/346 (3%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + + E L N+NV + RTALH A H V LL A ++ DK
Sbjct: 114 AAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD 173
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
IH AA+ G +EV+ +LV GA+ K++ + LH A S + +V+YL+ DL + D
Sbjct: 174 RRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL-DLGV-D 231
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+N+P+ G P +A G ++ +L ++K++ ++ L AA + +
Sbjct: 232 MNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAS-------TH 284
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
AL +E G V+ S + G T LH+ A HG Q ++ I+ ++
Sbjct: 285 GALCLELLVGNGADVNMKS----KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 340
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
+ L IA R GH L+N L++ D ++ PLHL ++ LLS+ DID
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
+ +T LH AA GN+E + LL G D DK G++ L A+
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446
Score = 134 bits (338), Expect = 2e-31
Identities = 109/383 (28%), Positives = 176/383 (45%), Gaps = 17/383 (4%)
Query: 64 LLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKH 123
L L ++ S A + + D + L KK ++N +N RT LH A ++ L+
Sbjct: 4 LKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS 63
Query: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
ARV+ D LT +H A S S E + +L+K AD A++++ + LH A + V+
Sbjct: 64 GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCA 123
Query: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTL-WTA 242
E L+ L ++N D GR AA GH EM++ L + + DK + W A
Sbjct: 124 EALVP--LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAA 181
Query: 243 ALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQ 302
+ ++ ++ S G V+ + T LH AA G V+ LL
Sbjct: 182 YMGHIE---------VVKLLVSHGAEVTCKD----KKSYTPLHAAASSGMISVVKYLLDL 228
Query: 303 WQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVV 362
D+NE N + L +A NG +VN L+ ++QK E +PLH + H +
Sbjct: 229 GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC 288
Query: 363 NSLLSAQ-HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASR 421
LL D+++ ++ +TPLH+ A G +T++++G + DK G T L +A+R
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348
Query: 422 SNHSLVVGMLIKAERYYAWREEH 444
H L++ LI + A R H
Sbjct: 349 YGHELLINTLITSGADTAKRGIH 371
Score = 125 bits (314), Expect = 9e-29
Identities = 96/352 (27%), Positives = 167/352 (47%), Gaps = 15/352 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + +++E L +N ++ T LH AV AV LLKH A V+ DK+
Sbjct: 48 AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW 107
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+AA + +++ LV ++ ++ G +ALH A S H +V+ L+ +
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS--RGAN 165
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+N D+K R+ AA GH+E+++ L + KDK ++ L AA + M + +
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
L GV + + GNT LH+A +G V L+ +N+ NE
Sbjct: 226 LDL----------GVDMNEPNAY--GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGF 273
Query: 315 SSLQIATRNGHASL-VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
+ L A + H +L + L+ D++ K + ++PLH+ ++ + +++ + ID
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID 333
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHS 425
++ TPLH+AA G+ L+ TL+ +G D G L +A+ S S
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385
Score = 108 bits (271), Expect = 9e-24
Identities = 107/389 (27%), Positives = 172/389 (44%), Gaps = 33/389 (8%)
Query: 57 TAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSA 116
+A GH L L Q A LD++ + + + N + LH A H A
Sbjct: 512 SAAYGHRLCL------QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQA 565
Query: 117 VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQD-GMSALHFAT 175
++ L++ +DV + G T + LAA+ G +E + +L+ GA K+ + +H A
Sbjct: 566 LEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625
Query: 176 QSNHVRIVEYLIQDLHLKD-LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKI 234
+ H + LI + ++ ++ D G+ P +L+ GH + + L + KDK
Sbjct: 626 TNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKW 685
Query: 235 QWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG--GNTALHLAAKHGH 292
+ L A+T + + AL GA LL+ G T +HL+A GH
Sbjct: 686 GRTALHRGAVTGHE---ECVDALLQHGA-----------KCLLRDSRGRTPIHLSAACGH 731
Query: 293 SPAVQVLL--AQWQDINEMNELN--ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKE- 347
+ LL A D N N ++L A NGH + V LL + V QK E
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV--FQKTEGNAF 789
Query: 348 SPLHLVVINNHITVVNSLLSA--QHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
SPLH VIN++ L+ ++ + K +TPLH AA +VE ++ LL +
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849
Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIKA 434
+VD GKT L +A+ + + V ML+ +
Sbjct: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
Score = 105 bits (262), Expect = 1e-22
Identities = 108/398 (27%), Positives = 179/398 (44%), Gaps = 39/398 (9%)
Query: 56 DTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLS 115
DTA G + P AA S D KL +I+ ++ RT LH A +L
Sbjct: 364 DTAKRGIHGMFP----LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
Query: 116 AVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFA- 174
++ LL A + DK G + +H AA + + + + LV +GA ++ G + LH+A
Sbjct: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Query: 175 TQSNHVRIVEYLIQDLHLKDLNQP--DEKGRKPFLLAAERGH---VEMIEKLTFLN--LH 227
T + +EYL+++ D N D++G +A GH +++I T L+ +
Sbjct: 480 TSDTDGKCLEYLLRN----DANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLME 535
Query: 228 TSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQ------GGN 281
TS D + S +R +I+ L + + SLL G
Sbjct: 536 TSGTDMLSDSD-----------NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNE-LNISSLQIATRNGHASLVNFLLSENVDLH 340
T L LAA GH V VL+ Q I + L + + A NGH+ + L+ N +
Sbjct: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG-NAEPQ 643
Query: 341 QKVEPKE----SPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVE 396
V+ ++ +PL L V+N H V SLL+ ++D ++ +T LH A G+ E V+
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVD 703
Query: 397 TLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
LL+ G D +G+T + +++ H V+G L+++
Sbjct: 704 ALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQS 741
Score = 102 bits (255), Expect = 7e-22
Identities = 96/343 (27%), Positives = 146/343 (42%), Gaps = 38/343 (11%)
Query: 94 INVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLML 153
+++ + +T L +V H V LL A VD DK G T +H A +G E + L
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705
Query: 154 VKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLN--QPDEKGRKPFLLAAE 211
++ GA ++ G + +H + H+ ++ L+Q D N D G A
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACY 765
Query: 212 RGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI------EGACSP 265
GH +E L E++ Q KT N+ + L EGA
Sbjct: 766 NGHETCVELLL-------EQEVFQ------------KTEGNAFSPLHCAVINDNEGAAE- 805
Query: 266 GTGVSTSSVSLLQG----GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIAT 321
+ T S++ G T LH AA H +Q+LL+ +N ++ + L +A
Sbjct: 806 -MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAA 864
Query: 322 RNGHASLVNFLLSE-NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ- 379
NG + V L+S + +L + K + LHL H T +L D +++N
Sbjct: 865 ENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNA 924
Query: 380 --QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKT-ALAVA 419
QTPLHVAA G +V+ LL G + AVD+ G T ALA A
Sbjct: 925 ALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967
Score = 91.7 bits (226), Expect = 2e-18
Identities = 80/301 (26%), Positives = 122/301 (40%), Gaps = 50/301 (16%)
Query: 78 SNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTV 137
+ + D + L K N++ + RTALH H VD LL+H A+ + D G T
Sbjct: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722
Query: 138 IHLAAWSGSLEVMLMLVKAGADQRAK----NQDGMSALHFATQSNHVRIVEYLIQD---- 189
IHL+A G + V+ L+++ A A + G +ALH+A + H VE L++
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782
Query: 190 ----------------------------LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
L +N D KGR P AA HVE ++ L
Sbjct: 783 KTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842
Query: 222 TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN 281
N + D ST T + + + + + + A + T S N
Sbjct: 843 LSHNAQVNSVD----STGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK-------N 891
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNI---SSLQIATRNGHASLVNFLLSENVD 338
TALHLA GH + ++L + D N +N N + L +A RNG +V LL +
Sbjct: 892 TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGAS 951
Query: 339 L 339
+
Sbjct: 952 V 952
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 138 bits (347), Expect = 1e-32
Identities = 107/364 (29%), Positives = 175/364 (48%), Gaps = 31/364 (8%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + E L ++NV + R+ALH AV HL V+ LL A ++V DK
Sbjct: 114 AAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE 173
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
+H AA+ G LEV+ +LV GAD K++ G LH A S + +V+YL++ +
Sbjct: 174 RQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR--MGAE 231
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+++P+ G +A G + +L + ++ + ++ L AA+ ++
Sbjct: 232 IDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAV-------STN 284
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
AL +E + G V+ S + G + LH+AA HG Q+L+ +I+ ++
Sbjct: 285 GALCLELLVNNGADVNYQS----KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGN 340
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVI-------------NNHITV 361
+ L +A R GH L++ L++ D ++ PLHL V+ ++
Sbjct: 341 TPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSI 400
Query: 362 VNSL-----LSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTAL 416
V+SL LSA DI+ + +T LH AA GNVE + LL +G DL+ DK G+T L
Sbjct: 401 VSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPL 460
Query: 417 AVAS 420
A+
Sbjct: 461 HYAA 464
Score = 116 bits (291), Expect = 4e-26
Identities = 97/371 (26%), Positives = 169/371 (45%), Gaps = 17/371 (4%)
Query: 64 LLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKH 123
L + ++ A S +++ + L +K NINV++ RT LH A + + LL
Sbjct: 4 LSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63
Query: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
A V+ D LT +H AA S + +V+ +L+ AD A+++ + LH A + +
Sbjct: 64 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 123
Query: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTL-WTA 242
E L L LN D GR A GH+E + L + DK + L W A
Sbjct: 124 EALAP--LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAA 181
Query: 243 ALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQ 302
L ++ + +A G + + G LH AA G V+ LL
Sbjct: 182 FLGHLEVLKLLVAR---------GADLGCKD----RKGYGLLHTAAASGQIEVVKYLLRM 228
Query: 303 WQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVIN-NHITV 361
+I+E N ++L IA G ++ L++ +++Q + +PLH+ ++ N
Sbjct: 229 GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALC 288
Query: 362 VNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASR 421
+ L++ D++ +++ ++PLH+AA G + L++ G ++ DK G T L VA+R
Sbjct: 289 LELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAAR 348
Query: 422 SNHSLVVGMLI 432
H L++ L+
Sbjct: 349 YGHELLISTLM 359
Score = 99.0 bits (245), Expect = 9e-21
Identities = 94/356 (26%), Positives = 153/356 (42%), Gaps = 23/356 (6%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMN---RTALHFAVGRNHLSAVDFLLKHKARVDVAD 131
AA S + D + L + ++ + M+ +T L A+ H+ V LL+ + D AD
Sbjct: 659 AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAAD 718
Query: 132 KHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
G T +H A +G + + L+ A ++ G + +H A+ H ++ L+Q
Sbjct: 719 LRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAAL 778
Query: 192 LKDLNQP--DEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM-K 248
D D G P A+ GH + +E L + S + ++ L A +
Sbjct: 779 STDPLDAGVDYSGYSPMHWASYTGHEDCLE-LLLEHSPFSYLEGNPFTPLHCAVINNQDS 837
Query: 249 TSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINE 308
T+ + AL G + S + G T LH AA + +++LL ++N
Sbjct: 838 TTEMLLGAL--------GAKIVNSRDAK---GRTPLHAAAFADNVSGLRMLLQHQAEVNA 886
Query: 309 MNELNISSLQIATRNGHASLVNFLLSEN-VDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
+ ++L A NG + V FLL DL E K + LHL H +L+
Sbjct: 887 TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILA 946
Query: 368 AQHDIDILNQKQ---QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKT-ALAVA 419
D+ ++N Q PLH+AA G +V+ LL G + AVD++G T ALA A
Sbjct: 947 ETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002
Score = 98.6 bits (244), Expect = 1e-20
Identities = 99/368 (26%), Positives = 152/368 (41%), Gaps = 23/368 (6%)
Query: 75 AAKSNNLDLMEKLFEKKVNI--NVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADK 132
AA N +E L E N +V + + + LH A H A+ L + +DV D
Sbjct: 557 AAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDH 616
Query: 133 HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGM-SALHFATQSNHVRIVEYLIQDLH 191
G T + LA GS E + +L GA K + + LH A S H + LI
Sbjct: 617 KGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGE 676
Query: 192 LKDLNQP-DEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
D+ D G+ P +LA GHV+ + L D + L A+T +
Sbjct: 677 RADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE-- 734
Query: 251 RNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMN 310
+ +AAL A G T +HLA+ GH+ ++ LL + ++
Sbjct: 735 -DCLAALLDHDAFVLCRDFK---------GRTPIHLASACGHTAVLRTLLQAALSTDPLD 784
Query: 311 E----LNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLL 366
S + A+ GH + LL + + + P +PLH VINN + LL
Sbjct: 785 AGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLL 843
Query: 367 SA--QHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNH 424
A ++ + K +TPLH AA NV + LL+ ++ A D G+TAL A+ +
Sbjct: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903
Query: 425 SLVVGMLI 432
+ V L+
Sbjct: 904 TAAVEFLL 911
Score = 97.8 bits (242), Expect = 2e-20
Identities = 92/336 (27%), Positives = 153/336 (45%), Gaps = 21/336 (6%)
Query: 85 EKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWS 144
E + +IN +N+ RT LH A ++ ++ LL A + DK G T +H AA +
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 145 GSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRK 204
GS + + LV AGA + G S LH+A S+ R E H + ++P ++ R+
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRR 526
Query: 205 PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACS 264
+ +E L S +D+ ++ + AA +N L + C
Sbjct: 527 -------KEAFFCLEFLLDNGADPSLRDRQGYTAVHYAA--AYGNRQNLELLLEMSFNCL 577
Query: 265 PGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNG 324
ST VS LHLAA +GH A++ L +++ + ++L +AT G
Sbjct: 578 EDV-ESTIPVS-------PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERG 629
Query: 325 HASLVNFLLSENVD-LHQKVEPKESPLHLVVINNHITVVNSLLSA--QHDI-DILNQKQQ 380
V L + L ++ + K +PLH + H ++ L+ + + DI D+++ Q
Sbjct: 630 STECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689
Query: 381 TPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTAL 416
TPL +A G+V+ V LL+ G A D +G+TAL
Sbjct: 690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725
Score = 81.6 bits (200), Expect = 2e-15
Identities = 64/242 (26%), Positives = 107/242 (44%), Gaps = 12/242 (4%)
Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
+++N D++ R P AA G V +++ L + + KD TLW L + SRN
Sbjct: 32 ENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD-----TLWLTPLHRAAASRN 86
Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
+ G + + L Q T LH+AA + + + L +N +
Sbjct: 87 E----KVLGLLLAHSADVNARDKLWQ---TPLHVAAANRATKCAEALAPLLSSLNVADRS 139
Query: 313 NISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDI 372
S+L A +GH VN LL++ L+ + + PLH H+ V+ L++ D+
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199
Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
++K LH AA G +E+V+ LL+ G ++ + G TAL +A V L+
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259
Query: 433 KA 434
A
Sbjct: 260 NA 261
Score = 76.3 bits (186), Expect = 7e-14
Identities = 95/424 (22%), Positives = 171/424 (40%), Gaps = 57/424 (13%)
Query: 52 LGEEDTAVAGHELLLPNERS---FQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFA 108
L E AG ++ P+ AA N++ + L ++ + RT LH+A
Sbjct: 404 LSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Query: 109 VGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE-------------------- 148
L+ A V+ AD G + +H AA S +
Sbjct: 464 AANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKE 523
Query: 149 --------VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLH--LKDLNQP 198
+ L+ GAD +++ G +A+H+A + + +E L++ L+D+
Sbjct: 524 SRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVEST 583
Query: 199 DEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALT 258
P LAA GH E ++ L ++ +D + L+ A + S + LT
Sbjct: 584 IPVS--PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAT---ERGSTECVEVLT 638
Query: 259 IEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQ--DINE-MNELNIS 315
GA ++ + + T LH AA GH+ ++ +L+ + DI + M+ +
Sbjct: 639 AHGA--------SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQT 690
Query: 316 SLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDIL 375
L +A NGH V+ LL + + LH + + +LL HD +L
Sbjct: 691 PLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLD--HDAFVL 748
Query: 376 NQ--KQQTPLHVAADRGNVELVETLLKAGCDL----KAVDKQGKTALAVASRSNHSLVVG 429
+ K +TP+H+A+ G+ ++ TLL+A VD G + + AS + H +
Sbjct: 749 CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808
Query: 430 MLIK 433
+L++
Sbjct: 809 LLLE 812
Score = 54.3 bits (129), Expect = 3e-07
Identities = 42/155 (27%), Positives = 75/155 (48%), Gaps = 9/155 (5%)
Query: 74 NAAKSNNLDLMEKLFEKKVNINVVNNMN---RTALHFAVGRNHLSAVDFLLKHKARVDVA 130
+ A NN D ++ + +VN+ + RT LH A +++S + LL+H+A V+
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNAT 887
Query: 131 DKHGLTVIHLAAWSG-SLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLI-- 187
D G T + AA +G + V +L + AD +++ +ALH A H + ++
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE 947
Query: 188 -QDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
QDL L +N + + P +AA G +++ L
Sbjct: 948 TQDLGL--INATNSALQMPLHIAARNGLASVVQAL 980
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 135 bits (340), Expect = 9e-32
Identities = 103/347 (29%), Positives = 167/347 (48%), Gaps = 17/347 (4%)
Query: 87 LFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGS 146
L K ++N +++ RT LH A ++ L+ ARV+ D LT +H A S S
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 147 LEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPF 206
E + +L+K AD A++++ + LH A + V+ E +I L +N D GR
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIP--LLSSVNVSDRGGRTAL 119
Query: 207 LLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTL-WTAALTKMKTSRNSIAALTIEGACSP 265
AA GHVEM+ L + + DK L W A + + + AL I +
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHL-----DVVALLI----NH 170
Query: 266 GTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGH 325
G V+ + G T LH AA +G V+ LL +I+E+N ++L IA NG
Sbjct: 171 GAEVTCKD----KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226
Query: 326 ASLVNFLLSENVDLHQKVEPKESPLHLVVINNH-ITVVNSLLSAQHDIDILNQKQQTPLH 384
++VN L+ +++Q +PLH + H + L++ D++I ++ ++PLH
Sbjct: 227 DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286
Query: 385 VAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
+ A G +TL++ G ++ VDK G T L VA+R H L++ L
Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
Score = 135 bits (339), Expect = 1e-31
Identities = 102/362 (28%), Positives = 158/362 (43%), Gaps = 46/362 (12%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
+ +AA + +++++ L K NIN + +R ALH+A HL V L+ H A V
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
DK G T +H AA +G + V+ L+ G + N G +ALH A + +V LI
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID-- 235
Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
+ ++NQP+ G P AA H
Sbjct: 236 YGANVNQPNNNGFTPLHFAAASTH------------------------------------ 259
Query: 251 RNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMN 310
AL +E + G V+ S + G + LH+ A HG Q L+ +I+ ++
Sbjct: 260 ----GALCLELLVNNGADVNIQS----KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311
Query: 311 ELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQH 370
+ + L +A R GH L+N L + D + PLHL +N H LLS+
Sbjct: 312 KDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371
Query: 371 DIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGM 430
+ID ++ +T LH AA GNVE ++ L +G D DK G+T L A+ + H +
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 431 LI 432
L+
Sbjct: 432 LV 433
Score = 130 bits (326), Expect = 4e-30
Identities = 95/352 (26%), Positives = 167/352 (47%), Gaps = 15/352 (4%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA + +++E L +N +NM T LH AV AV L+KH A V+ DK+
Sbjct: 23 AAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNW 82
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H+AA + +++ +++ + ++ G +ALH A + HV +V L+ +
Sbjct: 83 QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL--AKGAN 140
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+N D+K R+ AA GH++++ L + KDK ++ L AA +
Sbjct: 141 INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHL 200
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
L GV +++ GNTALH+A +G V L+ ++N+ N
Sbjct: 201 LNL----------GVEIDEINVY--GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248
Query: 315 SSLQIATRNGHASL-VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
+ L A + H +L + L++ D++ + + +SPLH+ ++ T +L+ +ID
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHS 425
+++ TPLHVAA G+ L+ TL +G D L +A+ + HS
Sbjct: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360
Score = 114 bits (286), Expect = 2e-25
Identities = 108/393 (27%), Positives = 168/393 (42%), Gaps = 44/393 (11%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFA-----------VGRNHLSA------- 116
AA + + +E L N+N ++ RTALH+A +G H ++
Sbjct: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAR 479
Query: 117 ----------VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQD 166
++FLL++ A + DK G IH AA G + + +L++ ++
Sbjct: 480 ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539
Query: 167 GM--SALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFL 224
G S LH A + H + +E L+Q L DL+ DEKGR LAA +GH E +E L
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSL--VDLDIRDEKGRTALDLAAFKGHTECVEALINP 597
Query: 225 NLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTAL 284
KD + T A++ T L +E A +P V G T L
Sbjct: 598 GASIFVKDNVTKRTPLHASVINGHTL---CLRLLLEIADNP-EAVDVKDAK----GQTPL 649
Query: 285 HLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVE 344
LA +GH AV +LL + +++ ++ L ++L GH V LL + V + K
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709
Query: 345 PKESPLHLVVINNHITVVNSLLS---AQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+PLH H T ++ LL ++ D + + TPLH A GN +E LL+
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
C K + T L A ++H +L+ A
Sbjct: 770 KCFRKFIGNP-FTPLHCAIINDHGNCASLLLGA 801
Score = 114 bits (285), Expect = 2e-25
Identities = 103/364 (28%), Positives = 161/364 (44%), Gaps = 46/364 (12%)
Query: 105 LHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKN 164
LH A H LL +D DK G T +H AA G++E + +L +GAD K+
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410
Query: 165 QDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAA-------------- 210
+ G + LH+A + H +E L+ ++N+ D+ GR AA
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTG--ANVNETDDWGRTALHYAAASDMDRNKTILGNA 468
Query: 211 -------ERGHVEMIEK-----LTFL---NLHTSEKDKIQWSTLWTAALTKMKTSRNSIA 255
ER E+ EK L FL + + S +DK ++++ AA + +
Sbjct: 469 HDNSEELERAR-ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
Query: 256 ALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNIS 315
T G +G + S LHLAA +GH A++VLL D++ +E +
Sbjct: 528 ERTNSGFEESDSGATKSP----------LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577
Query: 316 SLQIATRNGHASLVNFLLSENVDLHQKVE-PKESPLHLVVINNHITVVNSLLSAQHD--- 371
+L +A GH V L++ + K K +PLH VIN H + LL +
Sbjct: 578 ALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEA 637
Query: 372 IDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
+D+ + K QTPL +A G+++ V LL+ ++ VD G TAL + H V ML
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697
Query: 432 IKAE 435
++ E
Sbjct: 698 LEQE 701
Score = 92.4 bits (228), Expect = 9e-19
Identities = 103/414 (24%), Positives = 167/414 (40%), Gaps = 75/414 (18%)
Query: 83 LMEKLFEKKVNINVVNNMNRTALHFAVGRNHLS-AVDFLLKHKARVDVADKHGLTVIHLA 141
++ +L + N+N NN T LHFA H + ++ L+ + A V++ K G + +H+
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288
Query: 142 AWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYL--------------I 187
A G L++ G + ++DG + LH A + H ++ L +
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM 348
Query: 188 QDLHLKDLNQ-----------------PDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSE 230
LHL LN PD+ GR AA G+VE I+ L +
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHK 408
Query: 231 KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKH 290
KDK + L AA + IE + G V+ + G TALH AA
Sbjct: 409 KDKCGRTPLHYAAA--------NCHFHCIETLVTTGANVNETD----DWGRTALHYAAAS 456
Query: 291 GHSPAVQVL---------LAQWQDINE-----------MNELNIS--------SLQIATR 322
+L L + +++ E N+ N S S+ A
Sbjct: 457 DMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516
Query: 323 NGHASLVNFLLSENVDLHQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQ 380
GH + LL ++ + +SPLHL N H + LL + D+DI ++K +
Sbjct: 517 YGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGR 576
Query: 381 TPLHVAADRGNVELVETLLKAGCDLKAVDKQGK-TALAVASRSNHSLVVGMLIK 433
T L +AA +G+ E VE L+ G + D K T L + + H+L + +L++
Sbjct: 577 TALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630
Score = 82.0 bits (201), Expect = 1e-15
Identities = 80/302 (26%), Positives = 130/302 (43%), Gaps = 17/302 (5%)
Query: 81 LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHL 140
L L+ ++ + ++V + +T L AV H+ AV LL+ +A VD D G T +H
Sbjct: 625 LRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHR 684
Query: 141 AAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLKDLNQPD 199
+G E + ML++ K+ G + LH+A H + L+Q L +D D
Sbjct: 685 GIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKD 744
Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQW-STLWTAALTKMKTSRNSIAALT 258
+G P A G+ IE L +K ++ +T + + A+L
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLL------EQKCFRKFIGNPFTPLHCAIINDHGNCASLL 798
Query: 259 IEGACSPGTGVSTSSVSLLQG-GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSL 317
+ GA + +S VS G T L AA H +Q+LL +N ++ ++L
Sbjct: 799 L-GA------IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851
Query: 318 QIATRNGHASLVNFLL-SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILN 376
+A NG A V+ L+ S DL K + +PLHL H +L D ++N
Sbjct: 852 MMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911
Query: 377 QK 378
+K
Sbjct: 912 EK 913
Score = 68.6 bits (166), Expect = 1e-11
Identities = 68/274 (24%), Positives = 106/274 (38%), Gaps = 46/274 (16%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
A ++D + L EK+ N++ V+ + TALH + H V LL+ + + D G
Sbjct: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711
Query: 135 LTVIHLAAWSGS---LEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD-- 189
T +H AA G L +L + + D K+ G + LH+A + + +E L++
Sbjct: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771
Query: 190 -----------LHLKDLNQP-------------------DEKGRKPFLLAAERGHVEMIE 219
LH +N D+KGR P AA HVE ++
Sbjct: 772 FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQ 831
Query: 220 KLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
L + + D + L AA N A S ++ L
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMAA-------ENGQAGAVDILVNSAQADLTVKDKDL--- 881
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
NT LHLA GH ++L + QD + +NE N
Sbjct: 882 -NTPLHLACSKGHEKCALLILDKIQDESLINEKN 914
Score = 59.7 bits (143), Expect = 6e-09
Identities = 35/135 (25%), Positives = 67/135 (49%)
Query: 298 VLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINN 357
+L+ + +D+N ++ + L +A G A ++ L+ ++ K +PLH V +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 358 HITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALA 417
V L+ D++ ++ QTPLHVAA V+ E ++ + D+ G+TAL
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 418 VASRSNHSLVVGMLI 432
A+ + H +V +L+
Sbjct: 121 HAALNGHVEMVNLLL 135
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 134 bits (337), Expect = 2e-31
Identities = 96/364 (26%), Positives = 173/364 (47%), Gaps = 19/364 (5%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAV-----GRNHLSAVDFLLKHKARVDV 129
AA + +++E L + +N + RTAL A + H S V L+ A VD
Sbjct: 684 AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743
Query: 130 ADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD 189
DK G+T + +AA+ G ++V+ +L++ GAD + +G + L A H +V L+
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL-- 801
Query: 190 LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
++ D +GR +A+ +G+VE++ L L + +D W+ L AA
Sbjct: 802 FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE---- 857
Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
I IE G T+ + G LA++ GH VQ+LL +I++
Sbjct: 858 GHRLICEALIE------QGARTNEID--NDGRIPFILASQEGHYDCVQILLENKSNIDQR 909
Query: 310 NELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQ 369
++L++A GH +V L S D++ K L+++ + N +T+ L
Sbjct: 910 GYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENG 969
Query: 370 HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVG 429
+++ + + +T LHV+ +G++E+V+ L+ D+ A D + ++AL A+ H VV
Sbjct: 970 ANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQ 1029
Query: 430 MLIK 433
+LI+
Sbjct: 1030 LLIE 1033
Score = 132 bits (333), Expect = 6e-31
Identities = 95/359 (26%), Positives = 167/359 (46%), Gaps = 14/359 (3%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA ++D+++ L E +++ +N RT L A H S V+ LL A VD D G
Sbjct: 755 AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
TV+ +A+ G++EV+ L+ G D+ ++ G + LH A H I E LI+
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG--AR 872
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
N+ D GR PF+LA++ GH + ++ L + ++ + L AAL +
Sbjct: 873 TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD----- 927
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
+E S G V+ G L++ A + L ++ +
Sbjct: 928 ---IVELLFSHGADVNCKDAD----GRPTLYILALENQLTMAEYFLENGANVEASDAEGR 980
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
++L ++ GH +V L++ + D++ K S L H+ VV L+ +D
Sbjct: 981 TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ T L +AA G++++V+ LL+ G D D+ G+TA+ VA+++ HS ++ +L K
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099
Score = 130 bits (326), Expect = 4e-30
Identities = 96/360 (26%), Positives = 159/360 (44%), Gaps = 42/360 (11%)
Query: 74 NAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
NAA S +LD++ L + ++ + + T L A + H V+ L+ A ++ D+
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
G T + AAW G EV+ L+ AG + D +AL A H IV L+Q H
Sbjct: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQ--HGA 668
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
++N+ D +GR + AA GH E++E L + +D +
Sbjct: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV------------------DG 710
Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
AL++ C P A GH+ V +L+ + +++ ++
Sbjct: 711 RTALSVAALCVP----------------------ASKGHASVVSLLIDRGAEVDHCDKDG 748
Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
++ L +A GH +V+ LL D+ +PL H +VVN+LL +D
Sbjct: 749 MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVD 808
Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
++ + +T L +A+ +GNVE+V TLL G D D G T L +A+ H L+ LI+
Sbjct: 809 SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868
Score = 120 bits (300), Expect = 4e-27
Identities = 94/347 (27%), Positives = 160/347 (46%), Gaps = 19/347 (5%)
Query: 91 KVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVM 150
K +V + +RT+ ++ LL + A V+ D +G T++ AA+SGSL+V+
Sbjct: 502 KAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVV 561
Query: 151 LMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAA 210
+LV GAD ++ G + L A + H ++V LI ++N D+ G AA
Sbjct: 562 NLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG--CGANINHTDQDGWTALRSAA 619
Query: 211 ERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVS 270
GH E++ L + + D + L AA + + G V+
Sbjct: 620 WGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED--------IVLNLLQHGAEVN 671
Query: 271 TSSVSLLQGGNTALHLAAKHGHSPAVQVLL-----AQWQDINEMNELNISSLQIATRNGH 325
+ G TAL AA GH V+ LL +D++ L++++L + GH
Sbjct: 672 KAD----NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727
Query: 326 ASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHV 385
AS+V+ L+ ++ + +PL + H+ VV+ LL D+D + +TPL
Sbjct: 728 ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787
Query: 386 AADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
AA G+ +V TLL G + ++D +G+T L++AS + VV L+
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL 834
Score = 114 bits (286), Expect = 2e-25
Identities = 93/362 (25%), Positives = 155/362 (42%), Gaps = 19/362 (5%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ + ++ L NIN + TAL A H V LL +VD AD
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T + AAW G +++L L++ GA+ + +G +AL A H IVE+L+ H +
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD--HGAE 702
Query: 195 LNQPDEKGRKPFLLA-----AERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
+N D GR +A A +GH ++ L DK + L AA
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY----E 758
Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
+ L +EG G V + G T L AA GH+ V LL ++ +
Sbjct: 759 GHVDVVDLLLEG----GADVDHTD----NNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 310 NELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQ 369
+ + L IA+ G+ +V LL +D + + + +PLH+ H + +L+
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 370 HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVG 429
+ ++ + P +A+ G+ + V+ LL+ ++ G+ AL VA+ H +V
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930
Query: 430 ML 431
+L
Sbjct: 931 LL 932
Score = 60.8 bits (146), Expect = 3e-09
Identities = 41/139 (29%), Positives = 65/139 (46%)
Query: 295 AVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVV 354
+++ LL +N+ + + L A +G +VN L+S DL + +PL L
Sbjct: 527 SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586
Query: 355 INNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKT 414
H VVN L+ +I+ +Q T L AA G+ E+V LL AG + D +T
Sbjct: 587 RQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRT 646
Query: 415 ALAVASRSNHSLVVGMLIK 433
AL A+ H +V L++
Sbjct: 647 ALRAAAWGGHEDIVLNLLQ 665
Score = 48.9 bits (115), Expect = 1e-05
Identities = 31/106 (29%), Positives = 53/106 (50%)
Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
+ LL ++Q + L + + VVN L+S D++I + TPL +AA
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
+G+ ++V L+ G ++ D+ G TAL A+ H+ VV L+ A
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
Score = 47.0 bits (110), Expect = 4e-05
Identities = 27/88 (30%), Positives = 47/88 (53%)
Query: 71 SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
+ Q+AA ++ +++ L E ++ N TAL A H+ V LL+H A + A
Sbjct: 1015 ALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHA 1074
Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGA 158
D+ G T + +AA +G +++ +L K GA
Sbjct: 1075 DQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 131 bits (329), Expect = 2e-30
Identities = 98/359 (27%), Positives = 166/359 (46%), Gaps = 14/359 (3%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ NL+++++L + N N+ + N TAL A H+ V+ LLK ++ D G
Sbjct: 45 AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T + A + G +V+ +L+ GA+ + + +A H IV L+Q+
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG--AK 162
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
+N D+ G P + AA +GH+E ++ L + ++ + L A S I
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEI 222
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
+P ++ GNTAL +A+K GH+ VQ LL +N +
Sbjct: 223 LKR------NPNVNLTDKD------GNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGD 270
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
+ L A R GH +V LL + D+ + + ++ L+ V + T+V +L D +I
Sbjct: 271 TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEI 330
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ +TPL A N+E+VE LL G + AVDK+G T L +A R + +L++
Sbjct: 331 CTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389
Score = 87.0 bits (214), Expect = 4e-17
Identities = 65/245 (26%), Positives = 115/245 (46%), Gaps = 12/245 (4%)
Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
KD+++ +E G+ P ++AAE+G++E++++L + + +D W TA ++ K
Sbjct: 29 KDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW----TALISASKEGHV 84
Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
I +E G + + GG TAL A G + V++LL+ + +
Sbjct: 85 HI----VEELLKCGVNLEHRDM----GGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136
Query: 313 NISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDI 372
++ + A GHA +V+ LL ++ + +PL H+ V LL+ D+
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196
Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
D T L VA G + V+ +LK ++ DK G TAL +AS+ H+ +V L+
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256
Query: 433 KAERY 437
A Y
Sbjct: 257 DAGTY 261
Score = 54.7 bits (130), Expect = 2e-07
Identities = 30/80 (37%), Positives = 46/80 (57%)
Query: 354 VINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGK 413
V +I + +LL D+D N+ QTPL +AA++GN+E+V+ L+K G + D
Sbjct: 13 VEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW 72
Query: 414 TALAVASRSNHSLVVGMLIK 433
TAL AS+ H +V L+K
Sbjct: 73 TALISASKEGHVHIVEELLK 92
Score = 54.3 bits (129), Expect = 3e-07
Identities = 42/169 (24%), Positives = 86/169 (50%), Gaps = 10/169 (5%)
Query: 46 IPKREGLGE--EDTAVAGHELLLPNERS---FQNAAKSNNLDLMEKLFEKKVNINVVNNM 100
I +EG E +D AG + +P+ A + +++++ L +K +I++
Sbjct: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301
Query: 101 NRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQ 160
N+TAL++AV + + + V +L+ ++ K G T + A ++EV+ +L+ GA
Sbjct: 302 NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKV 361
Query: 161 RAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD---LNQPDEKGRKPF 206
A ++ G + LH A + ++ E L++ + KD L +P++ G P+
Sbjct: 362 SAVDKKGDTPLHIAIRGRSRKLAELLLR--NPKDGRLLYRPNKAGETPY 408
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 125 bits (315), Expect = 7e-29
Identities = 101/392 (25%), Positives = 172/392 (43%), Gaps = 25/392 (6%)
Query: 42 SLSRIPKREGLGEEDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMN 101
S R P LG D ++ +A S + + K+ + + ++++ +
Sbjct: 390 SFEREPSTSDLGTTDV----------QKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDSG 438
Query: 102 RTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQR 161
+ LH AV +LL + A +++++ G T +H+A V+ +L+
Sbjct: 439 ASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVN 498
Query: 162 AKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
AK++D +ALHFA Q+ L++ +N+ D +GR P +A + G ++ L
Sbjct: 499 AKDEDQWTALHFAAQNGDESSTRLLLEKN--ASVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 222 TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN 281
+ S + K W L AA L I + GVS ++ +L G
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQ---------GHLPIVKLLAKQPGVSVNAQTL--DGR 605
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
T LHLAA+ GH ++L+ D+N + L + L +A GH S LL
Sbjct: 606 TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA 665
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
+ LHL N H+ V L+ + D+ QT LH+AA G+ E+VE L+ A
Sbjct: 666 MTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA 725
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
+ D+QG +AL +A++ H+ V L++
Sbjct: 726 DV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 119 bits (299), Expect = 5e-27
Identities = 101/357 (28%), Positives = 149/357 (41%), Gaps = 14/357 (3%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ DL L + N V+ LHFA LL H A VD ++ G
Sbjct: 402 AAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG 461
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +HLAA + V +LV AD +G + LH A HV +V+ L +
Sbjct: 462 WTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG--AE 519
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
L+ R P LA ERG V I+ L D+ + L TAA +R
Sbjct: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA------ARGKY 573
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
C S G T LHLAA GH + +L ++ + +N
Sbjct: 574 LI------CKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNW 627
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
+ L +A R+G ++V+ LL D + + +PLHL V + V +LL ++
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
N+ TP H+AA +GN +++ L++AG L D T L +A RS ++ L
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 104 bits (259), Expect = 2e-22
Identities = 99/395 (25%), Positives = 164/395 (41%), Gaps = 44/395 (11%)
Query: 69 ERSFQNAAKSNNLDLMEKL--FEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKAR 126
+R+ Q + + N + E+L +E KV T LHF V + + V LL H+
Sbjct: 338 KRALQLSDRKNLVPRDEELCIYENKV----------TPLHFLVAQGSVEQVRLLLAHEVD 387
Query: 127 VDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYL 186
VD G T + +AA ++ +L+ GAD ++DG + LHFA Q+ L
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL 447
Query: 187 IQDLHLKDLNQPDEKGRKPFLLAAERGHVE----MIEKLTFLNLHTSE-KDKIQWSTLWT 241
+ H ++ + +G P LAA+ ++ + NLH +E K + + +
Sbjct: 448 LD--HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFG 505
Query: 242 -AALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
+L K+ TS+ G + +L T LHLA + G A+Q LL
Sbjct: 506 HVSLVKLLTSQ--------------GAELDAQQRNL----RTPLHLAVERGKVRAIQHLL 547
Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
+ +++ L A G + LL L +PLHL H+
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607
Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVA- 419
+++ L + ++ L TPLH+AA G +V LL+ G D A ++ G T L +A
Sbjct: 608 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667
Query: 420 SRSNHSLVVGML-----IKAERYYAWREEHHESIR 449
RS V+ +L + A W H +++
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALK 702
Score = 95.9 bits (237), Expect = 8e-20
Identities = 86/355 (24%), Positives = 149/355 (41%), Gaps = 14/355 (3%)
Query: 80 NLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIH 139
+++ + L +V+++ T L A LL H A + D+ G +H
Sbjct: 374 SVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLH 433
Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
AA +G +L+ GA A+ ++G + LH A Q+N + L+ D N +
Sbjct: 434 FAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS--RQADPNLHE 491
Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI 259
+G+ P +AA GHV +++ LT +E D Q + L + +I L
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLLTSQG---AELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Query: 260 EGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQI 319
GA +L Q G LH AA G ++LL + + L +
Sbjct: 549 SGAVPD---------ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599
Query: 320 ATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ 379
A GH +++ L + ++ +PLHL + VV++LL D + Q
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 380 QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
TPLH+A R V LL+ ++ A +K G T +A+ ++ ++ +L++A
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEA 714
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 117 bits (293), Expect = 3e-26
Identities = 91/367 (24%), Positives = 177/367 (48%), Gaps = 24/367 (6%)
Query: 70 RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV 129
RS + A+S++ E F K I+ +N+ N L +G LS D V+
Sbjct: 325 RSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGS--LSNYD--------VNQ 374
Query: 130 ADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD 189
+KHG + +AA G+++++ +L+K G+ +++ G +A+++A + HV +++L ++
Sbjct: 375 PNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434
Query: 190 LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
D+ D+ G +AA GH ++ + L + + +DK + + L AA +
Sbjct: 435 KCPLDVK--DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYS 492
Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
++ C G V+ + + G T L A+ G+ V+ L D+N
Sbjct: 493 VAKAL--------CEAGCNVNIKN----REGETPLLTASARGYHDIVECLAEHGADLNAC 540
Query: 310 NELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQ 369
++ +L +A R ++ LLS+ + + +PLH+ + ++ +V +L A
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 600
Query: 370 HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVG 429
++DI N+ +TPLH+AA+ G +++V L G ++A+ GKTA +A H V G
Sbjct: 601 CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG 660
Query: 430 MLIKAER 436
+L + +
Sbjct: 661 LLARLRK 667
Score = 95.5 bits (236), Expect = 1e-19
Identities = 71/291 (24%), Positives = 131/291 (45%), Gaps = 47/291 (16%)
Query: 156 AGADQRAKNQDG--MSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERG 213
A +D +D M A+ A ++V +++L+ L D+NQP++ G P L+AA G
Sbjct: 331 ARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCG 390
Query: 214 HVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSS 273
++++++ L +DK
Sbjct: 391 NIQILQLLIKRGSRIDVQDK---------------------------------------- 410
Query: 274 VSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLL 333
GG+ A++ AA+HGH ++ L ++ ++ +L +A R GHA + L
Sbjct: 411 -----GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC 465
Query: 334 SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVE 393
S + + + + +E+PLH + + +V +L A +++I N++ +TPL A+ RG +
Sbjct: 466 SFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHD 525
Query: 394 LVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEH 444
+VE L + G DL A DK G AL +A R V+ L+ + +++ H
Sbjct: 526 IVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH 576
Score = 78.6 bits (192), Expect = 1e-14
Identities = 69/267 (25%), Positives = 109/267 (40%), Gaps = 14/267 (5%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA+ ++D ++ L E K ++V + ALH A H L + ++ DK
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
T +H AAW G V L +AG + KN++G + L A+ + IVE L + H D
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAE--HGAD 536
Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
LN D+ G LA R +E+I+ L +D+ + L A K I
Sbjct: 537 LNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVAC----KDGNMPI 592
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
E C+ + S+ + G T LHLAA +G V+ L + +
Sbjct: 593 VVALCEANCN----LDISN----KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGK 644
Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQ 341
++ +A H + L D H+
Sbjct: 645 TAEDLARSEQHEHVAGLLARLRKDTHR 671
Score = 57.0 bits (136), Expect = 4e-08
Identities = 54/231 (23%), Positives = 94/231 (40%), Gaps = 14/231 (6%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E + AA+ + D+ + L N N+ + T LH A + S L + V+
Sbjct: 446 EMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVN 505
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+ ++ G T + A+ G +++ L + GAD A ++DG ALH A + + +++ L+
Sbjct: 506 IKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS 565
Query: 189 DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMK 248
D D G P +A + G++ ++ L N + +K + L AA
Sbjct: 566 QGCFVDYQ--DRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAA----- 618
Query: 249 TSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVL 299
N+ + C G V +L G TA LA H +L
Sbjct: 619 ---NNGILDVVRYLCLMGASVE----ALTTDGKTAEDLARSEQHEHVAGLL 662
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 113 bits (282), Expect = 5e-25
Identities = 92/333 (27%), Positives = 155/333 (46%), Gaps = 17/333 (5%)
Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
T L A H+ V LL HKA V+ G T + A G ++V+ +L+++GA
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 163 KNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLT 222
N++G + L A + HV + L+++ + + + K LA +GH+EM+ L
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK-ESALTLACYKGHLEMVRFL- 420
Query: 223 FLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNT 282
L + + + TA + +A L ++ G V+ + S +
Sbjct: 421 ---LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS----GAQVNMPADSF----ES 469
Query: 283 ALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH-Q 341
L LAA GH +L+ + + E+N+ + L A R GH +V LL + +++ Q
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
E +E+ L L + V + L+ A DI++ TPL AA G++ELV+ LL A
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAA 586
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
G ++ A G TAL A + H+ V +L++A
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQA 619
Score = 106 bits (265), Expect = 5e-23
Identities = 99/381 (25%), Positives = 159/381 (41%), Gaps = 27/381 (7%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
A +D+++ L E +I N T L A H+ LL++ A ++ +++
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
+ + LA + G LE++ L++AGADQ K + +AL A HV + L+
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--A 458
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------- 245
+N P + P LAA GHVE+ L E + ++ L AA
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Query: 246 --------KMKTSRNSIAALTIEGACSPG-----TGVSTSSVSLLQGGNTALHLAAKHGH 292
+T ALT+ AC G + + + G +T L AA+ GH
Sbjct: 519 LLGQGANINAQTEETQETALTL--ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576
Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
V+ LLA +++ ++L A NGH + + LL DL + E +PL
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 353 VVINNHITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQ 411
H+ V L+S +++ T L +A G++ +VE LL G D K
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
Query: 412 GKTALAVASRSNHSLVVGMLI 432
G T L A++ H+ VV L+
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLL 717
Score = 104 bits (260), Expect = 2e-22
Identities = 91/336 (27%), Positives = 151/336 (44%), Gaps = 18/336 (5%)
Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
TAL A H V LL+ A ++ DK G T + LAA +G + V+ +L+ GAD A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 163 KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
+++ L A +VE L+ K+ + P LAA G+V +I+ L
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 1202
Query: 222 TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
+ + K+ S L AA+ + L ++ + T+
Sbjct: 1203 LNAGAEINSRTGSKLGISPLMLAAMN----GHTAAVKLLLDMGSDINAQIETNR------ 1252
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
NTAL LA G + V +LL + ++ + ++ L A G+A + LL + D+
Sbjct: 1253 -NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311
Query: 340 HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
+ P +++ L + H L+ ID+ N+K TPL +AA+ G++++V+
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371
Query: 398 LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
L++AG D+ A D + T L A R H VV L+K
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 96.7 bits (239), Expect = 5e-20
Identities = 96/383 (25%), Positives = 156/383 (40%), Gaps = 54/383 (14%)
Query: 55 EDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHL 114
E TA AG + RS A +++ + KL + ++N + L A +
Sbjct: 225 ESTANAGQS----DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280
Query: 115 SAVDFLLKHKARV-DVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHF 173
LL A V D K +T + AA G ++++ +L+ AD A++ G +AL +
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 174 ATQSNHVRIVEYLIQD-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKD 232
A +V +V+ L++ ++D N E G P + A GHVE
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHN---ENGHTPLMEAGSAGHVE---------------- 381
Query: 233 KIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGH 292
+A L +E G G++T S + +AL LA GH
Sbjct: 382 ---------------------VARLLLEN----GAGINTHSNEFKE---SALTLACYKGH 413
Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
V+ LL D + ++L A +GH + LL ++ + ESPL L
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
Query: 353 VVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKA-VDKQ 411
H+ + L+ ++ +N + TPL AA G+ E+V LL G ++ A ++
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
Query: 412 GKTALAVASRSNHSLVVGMLIKA 434
+TAL +A V LIKA
Sbjct: 534 QETALTLACCGGFLEVADFLIKA 556
Score = 90.9 bits (224), Expect = 3e-18
Identities = 80/303 (26%), Positives = 143/303 (47%), Gaps = 16/303 (5%)
Query: 136 TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
T + LA G E++ L++ GA +++ G + L A + HV +VE L+ + D+
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG--ADI 1142
Query: 196 NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
E+ + P LA G E++E L + ++ ++ L AA S +
Sbjct: 1143 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA------SGGYV 1196
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
+ I + G +++ + S L G + L LAA +GH+ AV++LL DIN E N
Sbjct: 1197 NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252
Query: 315 SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
++ L +A G +V+ LL ++ + + +PL + V LL D++
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312
Query: 374 I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
+ + T L +AAD+G+ + E L+ G + +K+G T L +A+ H VV +L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Query: 432 IKA 434
++A
Sbjct: 1373 VQA 1375
Score = 71.6 bits (174), Expect = 2e-12
Identities = 48/155 (30%), Positives = 75/155 (48%), Gaps = 3/155 (1%)
Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
+TAL LA GH VQ LL + I ++ + L +A GH +V LL D+
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143
Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
Q K++PL L VV LL+ + + N TPL +AA G V +++ LL
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 400 KAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
AG ++ + K G + L +A+ + H+ V +L+
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 1238
Score = 65.9 bits (159), Expect = 9e-11
Identities = 44/141 (31%), Positives = 74/141 (52%), Gaps = 13/141 (9%)
Query: 64 LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
LLL + + ++ AK+ LME L +K ++N V + TAL A
Sbjct: 1270 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1329
Query: 111 RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
+ H + L+ A +DV +K G T + LAA G L+V+ +LV+AGAD A + ++
Sbjct: 1330 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1389
Query: 171 LHFATQSNHVRIVEYLIQDLH 191
L A + HV++V YL+++++
Sbjct: 1390 LMAAFRKGHVKVVRYLVKEVN 1410
Score = 65.1 bits (157), Expect = 2e-10
Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 29/288 (10%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
AA + ++ ++E L + +I + + T L A V+ LL A + +
Sbjct: 1123 AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
T + LAA G + ++ +L+ AGA+ R ++ G+S L A + H V+ L+ D+
Sbjct: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL-DMG 1241
Query: 192 LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
D+N E R L LA +G E++ L + + K + L AA
Sbjct: 1242 -SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1300
Query: 244 ------------LTKMKTSRNSIAALTIEGA----CSPGTGVSTSSVSLLQGGNTALHLA 287
+ +SR++ + + C G + GNT L LA
Sbjct: 1301 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1360
Query: 288 AKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
A GH VQ+L+ D++ + I+ L A R GH +V +L+ E
Sbjct: 1361 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 1/127 (0%)
Query: 62 HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
H + + A ++ + D+ + L + ++ + RT L A H+ V FL+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
Query: 122 KHKARVD-VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
A V+ + TV+ LA G L V+ +L+ GAD + +DG + L A + H
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 181 RIVEYLI 187
+V YL+
Sbjct: 711 SVVCYLL 717
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 113 bits (282), Expect = 5e-25
Identities = 92/333 (27%), Positives = 155/333 (46%), Gaps = 17/333 (5%)
Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
T L A H+ V LL HKA V+ G T + A G ++V+ +L+++GA
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 163 KNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLT 222
N++G + L A + HV + L+++ + + + K LA +GH+EM+ L
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK-ESALTLACYKGHLEMVRFL- 420
Query: 223 FLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNT 282
L + + + TA + +A L ++ G V+ + S +
Sbjct: 421 ---LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS----GAQVNMPADSF----ES 469
Query: 283 ALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH-Q 341
L LAA GH +L+ + + E+N+ + L A R GH +V LL + +++ Q
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
E +E+ L L + V + L+ A DI++ TPL AA G++ELV+ LL A
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAA 586
Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
G ++ A G TAL A + H+ V +L++A
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQA 619
Score = 106 bits (265), Expect = 5e-23
Identities = 99/381 (25%), Positives = 159/381 (41%), Gaps = 27/381 (7%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
A +D+++ L E +I N T L A H+ LL++ A ++ +++
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
+ + LA + G LE++ L++AGADQ K + +AL A HV + L+
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--A 458
Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------- 245
+N P + P LAA GHVE+ L E + ++ L AA
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518
Query: 246 --------KMKTSRNSIAALTIEGACSPG-----TGVSTSSVSLLQGGNTALHLAAKHGH 292
+T ALT+ AC G + + + G +T L AA+ GH
Sbjct: 519 LLGQGANINAQTEETQETALTL--ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576
Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
V+ LLA +++ ++L A NGH + + LL DL + E +PL
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 353 VVINNHITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQ 411
H+ V L+S +++ T L +A G++ +VE LL G D K
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696
Query: 412 GKTALAVASRSNHSLVVGMLI 432
G T L A++ H+ VV L+
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLL 717
Score = 104 bits (260), Expect = 2e-22
Identities = 91/336 (27%), Positives = 151/336 (44%), Gaps = 18/336 (5%)
Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
TAL A H V LL+ A ++ DK G T + LAA +G + V+ +L+ GAD A
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 163 KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
+++ L A +VE L+ K+ + P LAA G+V +I+ L
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 951
Query: 222 TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
+ + K+ S L AA+ + L ++ + T+
Sbjct: 952 LNAGAEINSRTGSKLGISPLMLAAMN----GHTAAVKLLLDMGSDINAQIETNR------ 1001
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
NTAL LA G + V +LL + ++ + ++ L A G+A + LL + D+
Sbjct: 1002 -NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060
Query: 340 HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
+ P +++ L + H L+ ID+ N+K TPL +AA+ G++++V+
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120
Query: 398 LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
L++AG D+ A D + T L A R H VV L+K
Sbjct: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 97.1 bits (240), Expect = 4e-20
Identities = 100/398 (25%), Positives = 167/398 (41%), Gaps = 28/398 (7%)
Query: 62 HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
H + + A ++ + D+ + L + ++ + RT L A H+ V FL+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650
Query: 122 KHKARVD-VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
A V+ + TV+ LA G L V+ +L+ GAD + +DG + L A + H
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710
Query: 181 RIVEYLIQ-DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDK------ 233
+V YL+ +L PD P R ++ L + + E DK
Sbjct: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMV-VPPQEPDKPPANVA 769
Query: 234 ----IQWSTLWTAALTKMKTSRNSIAA-LTIEGACSPGTGVSTSSVSLL----------- 277
I+ + A T +SIAA ++ +P +S S++ +
Sbjct: 770 TTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829
Query: 278 QGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENV 337
+TAL LA GH VQ LL + I ++ + L +A GH +V LL
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889
Query: 338 DLH-QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVE 396
D+ Q K++PL L VV LL+ + + N TPL +AA G V +++
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949
Query: 397 TLLKAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
LL AG ++ + K G + L +A+ + H+ V +L+
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 987
Score = 96.7 bits (239), Expect = 5e-20
Identities = 96/383 (25%), Positives = 156/383 (40%), Gaps = 54/383 (14%)
Query: 55 EDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHL 114
E TA AG + RS A +++ + KL + ++N + L A +
Sbjct: 225 ESTANAGQS----DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280
Query: 115 SAVDFLLKHKARV-DVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHF 173
LL A V D K +T + AA G ++++ +L+ AD A++ G +AL +
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340
Query: 174 ATQSNHVRIVEYLIQD-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKD 232
A +V +V+ L++ ++D N E G P + A GHVE
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHN---ENGHTPLMEAGSAGHVE---------------- 381
Query: 233 KIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGH 292
+A L +E G G++T S + +AL LA GH
Sbjct: 382 ---------------------VARLLLEN----GAGINTHSNEFKE---SALTLACYKGH 413
Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
V+ LL D + ++L A +GH + LL ++ + ESPL L
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473
Query: 353 VVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKA-VDKQ 411
H+ + L+ ++ +N + TPL AA G+ E+V LL G ++ A ++
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533
Query: 412 GKTALAVASRSNHSLVVGMLIKA 434
+TAL +A V LIKA
Sbjct: 534 QETALTLACCGGFLEVADFLIKA 556
Score = 90.9 bits (224), Expect = 3e-18
Identities = 80/303 (26%), Positives = 143/303 (47%), Gaps = 16/303 (5%)
Query: 136 TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
T + LA G E++ L++ GA +++ G + L A + HV +VE L+ + D+
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG--ADI 891
Query: 196 NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
E+ + P LA G E++E L + ++ ++ L AA S +
Sbjct: 892 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA------SGGYV 945
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
+ I + G +++ + S L G + L LAA +GH+ AV++LL DIN E N
Sbjct: 946 NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1001
Query: 315 SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
++ L +A G +V+ LL ++ + + +PL + V LL D++
Sbjct: 1002 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061
Query: 374 I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
+ + T L +AAD+G+ + E L+ G + +K+G T L +A+ H VV +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Query: 432 IKA 434
++A
Sbjct: 1122 VQA 1124
Score = 65.9 bits (159), Expect = 9e-11
Identities = 44/141 (31%), Positives = 74/141 (52%), Gaps = 13/141 (9%)
Query: 64 LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
LLL + + ++ AK+ LME L +K ++N V + TAL A
Sbjct: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078
Query: 111 RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
+ H + L+ A +DV +K G T + LAA G L+V+ +LV+AGAD A + ++
Sbjct: 1079 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1138
Query: 171 LHFATQSNHVRIVEYLIQDLH 191
L A + HV++V YL+++++
Sbjct: 1139 LMAAFRKGHVKVVRYLVKEVN 1159
Score = 65.1 bits (157), Expect = 2e-10
Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 29/288 (10%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
AA + ++ ++E L + +I + + T L A V+ LL A + +
Sbjct: 872 AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 931
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
T + LAA G + ++ +L+ AGA+ R ++ G+S L A + H V+ L+ D+
Sbjct: 932 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL-DMG 990
Query: 192 LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
D+N E R L LA +G E++ L + + K + L AA
Sbjct: 991 -SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049
Query: 244 ------------LTKMKTSRNSIAALTIEGA----CSPGTGVSTSSVSLLQGGNTALHLA 287
+ +SR++ + + C G + GNT L LA
Sbjct: 1050 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1109
Query: 288 AKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
A GH VQ+L+ D++ + I+ L A R GH +V +L+ E
Sbjct: 1110 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 108 bits (270), Expect = 1e-23
Identities = 96/375 (25%), Positives = 158/375 (42%), Gaps = 27/375 (7%)
Query: 81 LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
+D+++ L + NI N T L A H+ LL H A ++ +++ + +
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
LA + G L+++ L++AGADQ K + +AL A HV + L+ +N P
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 435
Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------------- 245
+ P LAA GHVE+ L + E + ++ L AA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 246 --KMKTSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQV 298
+T ALT+ AC G + + + G +T L A++ GH V+
Sbjct: 496 NINAQTEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553
Query: 299 LLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH 358
LLA +++ ++L A NGH + + LL DL + E +PL H
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
Query: 359 ITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALA 417
+ V L+S +++ T + +A G++ +VE LL G D K G T L
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673
Query: 418 VASRSNHSLVVGMLI 432
A++ H+ VV L+
Sbjct: 674 EAAKGGHTNVVSYLL 688
Score = 106 bits (265), Expect = 5e-23
Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)
Query: 70 RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
RS A +++ + KL ++ ++N + L A + LL A V D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+K +T + A+ G L+++ +L+ AD +++ G +AL +A V IV+ L+
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
+ +++D N E G P + AA GHVE+ L +N H++E
Sbjct: 327 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
D +++ L A + KT A + AC G V + + L G
Sbjct: 384 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 438
Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
+ L LAA GH +L+ + ++ E+N+ + L A R GH +V LL++ +++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
Q E +E+ L L V + L+ A DI++ TPL A+ G++ELV+ LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 555
Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
+G ++ A G TAL A + H+ V +L++A
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 590
Score = 97.8 bits (242), Expect = 2e-20
Identities = 87/336 (25%), Positives = 148/336 (44%), Gaps = 18/336 (5%)
Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
TAL A H V L+ A+++ DK G T + LAA +G + V+ +L+ G D A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 163 KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
+++ L A +V+ L+ K+ + P LAA G+V +I+ L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 1174
Query: 222 TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
+ + K+ S L AA+ L ++ + T+
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMN----GHVPAVKLLLDMGSDINAQIETNR------ 1224
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
NTAL LA G + V +LL + ++ + ++ L A G+A + LL + D+
Sbjct: 1225 -NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 340 HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
+ P +++ L + H L+ ID+ N+K TPL +A++ G+ ++V+
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 398 LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
L++AG D+ A D + T L A R H VV L+K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 91.3 bits (225), Expect = 2e-18
Identities = 81/303 (26%), Positives = 142/303 (46%), Gaps = 16/303 (5%)
Query: 136 TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
T + LA G E++ +L+ A +++ G + L A + HV +VE L+ D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG--DI 1114
Query: 196 NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
E+ + P LA G E+++ L + ++ ++ L AA S +
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA------SGGYV 1168
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
+ I + G +++ + S L G + L LAA +GH PAV++LL DIN E N
Sbjct: 1169 NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 315 SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
++ L +A G A +V+ LL ++ + + +PL + V LL D++
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 374 I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
+ + T L +AAD+G+ + E L+ G + +K+G T L +AS H VV +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 432 IKA 434
++A
Sbjct: 1345 VQA 1347
Score = 68.9 bits (167), Expect = 1e-11
Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 3/155 (1%)
Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
+TAL LA GH V VL+A+ I ++ + L +A GH +V LL + D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
Q K++PL L VV+ LL+ + + N TPL +AA G V +++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 400 KAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
AG ++ + K G + L +A+ + H V +L+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Score = 65.5 bits (158), Expect = 1e-10
Identities = 76/294 (25%), Positives = 125/294 (42%), Gaps = 41/294 (13%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
AA + ++ ++E L +K +I + + T L A VD LL A + +
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
T + LAA G + ++ +L+ AGA+ R ++ G+S L A + HV V+ L+ D+
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL-DMG 1213
Query: 192 LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
D+N E R L LA +G E++ L + + K + L AA
Sbjct: 1214 -SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
Query: 244 ------------LTKMKTSRNSIAALTI----------EGACSPGTGVSTSSVSLLQGGN 281
+ +SR++ ALTI E G + + + GN
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIHRGAHIDVRN----KKGN 1326
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
T L LA+ GH VQ+L+ D++ + I+ L A R GH +V +L+ E
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/261 (24%), Positives = 110/261 (42%), Gaps = 19/261 (7%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
AA +++L L E+ N+ VN+ T L A H V LL A ++ ++
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA-LHFATQSNHVRIVEYLIQDLHL 192
T + LA G EV L+KAGAD G S L A+Q H+ +V+YL+
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIEL----GCSTPLMEASQEGHLELVKYLLASG-- 558
Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
+++ G A E GH ++ + L + + T + +
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE--------GGRTPLMKAAR 610
Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
+ T++ S G V+ ++ + +T + LA GH V++LLA D +
Sbjct: 611 AGHLCTVQFLISKGANVNRATAN---NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
Query: 313 NISSLQIATRNGHASLVNFLL 333
+ L A + GH ++V++LL
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLL 688
Score = 64.3 bits (155), Expect = 3e-10
Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 13/141 (9%)
Query: 64 LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
LLL + + ++ AK+ LME L +K ++N V + TAL A
Sbjct: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
Query: 111 RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
+ H + L+ A +DV +K G T + LA+ G +V+ +LV+AGAD A + ++
Sbjct: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
Query: 171 LHFATQSNHVRIVEYLIQDLH 191
L A + HV++V+YL+++++
Sbjct: 1362 LMSAFRKGHVKVVQYLVKEVN 1382
Score = 62.4 bits (150), Expect = 1e-09
Identities = 63/248 (25%), Positives = 103/248 (41%), Gaps = 25/248 (10%)
Query: 75 AAKSNNLDLMEKLFEKKVNINV-VNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
AA+ + +++ L + NIN TAL A DFL+K A +++
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS- 536
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
T + A+ G LE++ L+ +GA+ A G +AL +A ++ H + + L+Q
Sbjct: 537 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG--A 592
Query: 194 DLNQPDEKGRKPFLLAAERGHV----EMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
DL E GR P + AA GH+ +I K +N T+ D T
Sbjct: 593 DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH-------TVVSLACAG 645
Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
++ L + P L+ G+T L AAK GH+ V LL ++ +
Sbjct: 646 GHLAVVELLLAHGADP--------THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 697
Query: 310 NELNISSL 317
++S L
Sbjct: 698 PTTDVSQL 705
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/127 (27%), Positives = 59/127 (46%), Gaps = 1/127 (0%)
Query: 62 HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
H + + A ++ + D+ + L + ++ + RT L A HL V FL+
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621
Query: 122 KHKARVDVADKHG-LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
A V+ A + TV+ LA G L V+ +L+ GAD + +DG + L A + H
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
Query: 181 RIVEYLI 187
+V YL+
Sbjct: 682 NVVSYLL 688
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 108 bits (270), Expect = 1e-23
Identities = 96/375 (25%), Positives = 158/375 (42%), Gaps = 27/375 (7%)
Query: 81 LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
+D+++ L + NI N T L A H+ LL H A ++ +++ + +
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
LA + G L+++ L++AGADQ K + +AL A HV + L+ +N P
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 435
Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------------- 245
+ P LAA GHVE+ L + E + ++ L AA
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495
Query: 246 --KMKTSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQV 298
+T ALT+ AC G + + + G +T L A++ GH V+
Sbjct: 496 NINAQTEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553
Query: 299 LLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH 358
LLA +++ ++L A NGH + + LL DL + E +PL H
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613
Query: 359 ITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALA 417
+ V L+S +++ T + +A G++ +VE LL G D K G T L
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673
Query: 418 VASRSNHSLVVGMLI 432
A++ H+ VV L+
Sbjct: 674 EAAKGGHTNVVSYLL 688
Score = 106 bits (265), Expect = 5e-23
Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)
Query: 70 RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
RS A +++ + KL ++ ++N + L A + LL A V D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+K +T + A+ G L+++ +L+ AD +++ G +AL +A V IV+ L+
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
+ +++D N E G P + AA GHVE+ L +N H++E
Sbjct: 327 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
D +++ L A + KT A + AC G V + + L G
Sbjct: 384 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 438
Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
+ L LAA GH +L+ + ++ E+N+ + L A R GH +V LL++ +++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
Q E +E+ L L V + L+ A DI++ TPL A+ G++ELV+ LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 555
Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
+G ++ A G TAL A + H+ V +L++A
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 590
Score = 97.8 bits (242), Expect = 2e-20
Identities = 87/336 (25%), Positives = 148/336 (44%), Gaps = 18/336 (5%)
Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
TAL A H V L+ A+++ DK G T + LAA +G + V+ +L+ G D A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 163 KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
+++ L A +V+ L+ K+ + P LAA G+V +I+ L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 1174
Query: 222 TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
+ + K+ S L AA+ L ++ + T+
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMN----GHVPAVKLLLDMGSDINAQIETNR------ 1224
Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
NTAL LA G + V +LL + ++ + ++ L A G+A + LL + D+
Sbjct: 1225 -NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283
Query: 340 HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
+ P +++ L + H L+ ID+ N+K TPL +A++ G+ ++V+
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343
Query: 398 LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
L++AG D+ A D + T L A R H VV L+K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 91.3 bits (225), Expect = 2e-18
Identities = 81/303 (26%), Positives = 142/303 (46%), Gaps = 16/303 (5%)
Query: 136 TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
T + LA G E++ +L+ A +++ G + L A + HV +VE L+ D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG--DI 1114
Query: 196 NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
E+ + P LA G E+++ L + ++ ++ L AA S +
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA------SGGYV 1168
Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
+ I + G +++ + S L G + L LAA +GH PAV++LL DIN E N
Sbjct: 1169 NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224
Query: 315 SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
++ L +A G A +V+ LL ++ + + +PL + V LL D++
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 374 I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
+ + T L +AAD+G+ + E L+ G + +K+G T L +AS H VV +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 432 IKA 434
++A
Sbjct: 1345 VQA 1347
Score = 68.9 bits (167), Expect = 1e-11
Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 3/155 (1%)
Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
+TAL LA GH V VL+A+ I ++ + L +A GH +V LL + D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
Q K++PL L VV+ LL+ + + N TPL +AA G V +++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 400 KAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
AG ++ + K G + L +A+ + H V +L+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Score = 65.5 bits (158), Expect = 1e-10
Identities = 76/294 (25%), Positives = 125/294 (42%), Gaps = 41/294 (13%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
AA + ++ ++E L +K +I + + T L A VD LL A + +
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
T + LAA G + ++ +L+ AGA+ R ++ G+S L A + HV V+ L+ D+
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL-DMG 1213
Query: 192 LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
D+N E R L LA +G E++ L + + K + L AA
Sbjct: 1214 -SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272
Query: 244 ------------LTKMKTSRNSIAALTI----------EGACSPGTGVSTSSVSLLQGGN 281
+ +SR++ ALTI E G + + + GN
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIHRGAHIDVRN----KKGN 1326
Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
T L LA+ GH VQ+L+ D++ + I+ L A R GH +V +L+ E
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380
Score = 64.7 bits (156), Expect = 2e-10
Identities = 65/261 (24%), Positives = 110/261 (42%), Gaps = 19/261 (7%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
AA +++L L E+ N+ VN+ T L A H V LL A ++ ++
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA-LHFATQSNHVRIVEYLIQDLHL 192
T + LA G EV L+KAGAD G S L A+Q H+ +V+YL+
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIEL----GCSTPLMEASQEGHLELVKYLLASG-- 558
Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
+++ G A E GH ++ + L + + T + +
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE--------GGRTPLMKAAR 610
Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
+ T++ S G V+ ++ + +T + LA GH V++LLA D +
Sbjct: 611 AGHLCTVQFLISKGANVNRATAN---NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKD 667
Query: 313 NISSLQIATRNGHASLVNFLL 333
+ L A + GH ++V++LL
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLL 688
Score = 64.3 bits (155), Expect = 3e-10
Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 13/141 (9%)
Query: 64 LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
LLL + + ++ AK+ LME L +K ++N V + TAL A
Sbjct: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
Query: 111 RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
+ H + L+ A +DV +K G T + LA+ G +V+ +LV+AGAD A + ++
Sbjct: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
Query: 171 LHFATQSNHVRIVEYLIQDLH 191
L A + HV++V+YL+++++
Sbjct: 1362 LMSAFRKGHVKVVQYLVKEVN 1382
Score = 62.4 bits (150), Expect = 1e-09
Identities = 63/248 (25%), Positives = 103/248 (41%), Gaps = 25/248 (10%)
Query: 75 AAKSNNLDLMEKLFEKKVNINV-VNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
AA+ + +++ L + NIN TAL A DFL+K A +++
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS- 536
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
T + A+ G LE++ L+ +GA+ A G +AL +A ++ H + + L+Q
Sbjct: 537 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG--A 592
Query: 194 DLNQPDEKGRKPFLLAAERGHV----EMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
DL E GR P + AA GH+ +I K +N T+ D T
Sbjct: 593 DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH-------TVVSLACAG 645
Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
++ L + P L+ G+T L AAK GH+ V LL ++ +
Sbjct: 646 GHLAVVELLLAHGADP--------THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 697
Query: 310 NELNISSL 317
++S L
Sbjct: 698 PTTDVSQL 705
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/127 (27%), Positives = 59/127 (46%), Gaps = 1/127 (0%)
Query: 62 HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
H + + A ++ + D+ + L + ++ + RT L A HL V FL+
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621
Query: 122 KHKARVDVADKHG-LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
A V+ A + TV+ LA G L V+ +L+ GAD + +DG + L A + H
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681
Query: 181 RIVEYLI 187
+V YL+
Sbjct: 682 NVVSYLL 688
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 106 bits (265), Expect = 5e-23
Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)
Query: 70 RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
RS A +++ + KL ++ ++N + L A + LL A V D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+K +T + A+ G L+++ +L+ AD +++ G +AL +A V IV+ L+
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326
Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
+ +++D N E G P + AA GHVE+ L +N H++E
Sbjct: 327 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383
Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
D +++ L A + KT A + AC G V + + L G
Sbjct: 384 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 438
Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
+ L LAA GH +L+ + ++ E+N+ + L A R GH +V LL++ +++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
Q E +E+ L L V + L+ A DI++ TPL A+ G++ELV+ LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 555
Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
+G ++ A G TAL A + H+ V +L++A
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 590
Score = 90.5 bits (223), Expect = 3e-18
Identities = 81/295 (27%), Positives = 126/295 (42%), Gaps = 19/295 (6%)
Query: 81 LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
+D+++ L + NI N T L A H+ LL H A ++ +++ + +
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377
Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
LA + G L+++ L++AGADQ K + +AL A HV + L+ +N P
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 435
Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI 259
+ P LAA GHVE+ L + E + ++ L AA + +A L
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA---REGHEEMVALLLA 492
Query: 260 EGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISS-LQ 318
+GA T TAL LA G S L+ DI EL S+ L
Sbjct: 493 QGANINAQTEETQE--------TALTLACCGGFSEVADFLIKAGADI----ELGCSTPLM 540
Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
A++ GH LV +LL+ ++H ++ L N H V + LL A D+D
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/283 (21%), Positives = 103/283 (36%), Gaps = 59/283 (20%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E + A +LD++ L E + + TAL A H+ LL A+V+
Sbjct: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+ + + LAA G +E+ +L++ GA+ N +G +
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT------------------- 473
Query: 189 DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMK 248
P + AA GH EM+ L L A +
Sbjct: 474 ----------------PLMEAAREGHEEMVALL-----------------LAQGANINAQ 500
Query: 249 TSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQW 303
T ALT+ AC G + + + G +T L A++ GH V+ LLA
Sbjct: 501 TEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG 558
Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPK 346
+++ ++L A NGH + + LL DL ++ + K
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 106 bits (265), Expect = 5e-23
Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)
Query: 70 RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
RS A +++ + KL ++ ++N + L A + LL A V D
Sbjct: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 255
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+K +T + A+ G L+++ +L+ AD +++ G +AL +A V IV+ L+
Sbjct: 256 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315
Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
+ +++D N E G P + AA GHVE+ L +N H++E
Sbjct: 316 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372
Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
D +++ L A + KT A + AC G V + + L G
Sbjct: 373 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 427
Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
+ L LAA GH +L+ + ++ E+N+ + L A R GH +V LL++ +++
Sbjct: 428 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487
Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
Q E +E+ L L V + L+ A DI++ TPL A+ G++ELV+ LL
Sbjct: 488 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 544
Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
+G ++ A G TAL A + H+ V +L++A
Sbjct: 545 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 579
Score = 90.5 bits (223), Expect = 3e-18
Identities = 81/295 (27%), Positives = 126/295 (42%), Gaps = 19/295 (6%)
Query: 81 LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
+D+++ L + NI N T L A H+ LL H A ++ +++ + +
Sbjct: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366
Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
LA + G L+++ L++AGADQ K + +AL A HV + L+ +N P
Sbjct: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 424
Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI 259
+ P LAA GHVE+ L + E + ++ L AA + +A L
Sbjct: 425 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA---REGHEEMVALLLA 481
Query: 260 EGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISS-LQ 318
+GA T TAL LA G S L+ DI EL S+ L
Sbjct: 482 QGANINAQTEETQE--------TALTLACCGGFSEVADFLIKAGADI----ELGCSTPLM 529
Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
A++ GH LV +LL+ ++H ++ L N H V + LL A D+D
Sbjct: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
Score = 51.6 bits (122), Expect = 2e-06
Identities = 62/283 (21%), Positives = 103/283 (36%), Gaps = 59/283 (20%)
Query: 69 ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
E + A +LD++ L E + + TAL A H+ LL A+V+
Sbjct: 362 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 421
Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
+ + + LAA G +E+ +L++ GA+ N +G +
Sbjct: 422 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT------------------- 462
Query: 189 DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMK 248
P + AA GH EM+ L L A +
Sbjct: 463 ----------------PLMEAAREGHEEMVALL-----------------LAQGANINAQ 489
Query: 249 TSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQW 303
T ALT+ AC G + + + G +T L A++ GH V+ LLA
Sbjct: 490 TEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG 547
Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPK 346
+++ ++L A NGH + + LL DL ++ + K
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 105 bits (261), Expect = 1e-22
Identities = 96/357 (26%), Positives = 148/357 (41%), Gaps = 60/357 (16%)
Query: 88 FEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSL 147
+ ++++IN +NN T LH AV L + L + A++D +K T IH AA G+
Sbjct: 226 YSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGAT 285
Query: 148 EVMLMLVK--AGADQRAKNQDGM--SALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGR 203
E++ +++ +G+ DG + LH A+ +H + +YLI D+N+ D +GR
Sbjct: 286 EIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLIS--VGADINKIDSEGR 343
Query: 204 KPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGAC 263
P +LA ++ L KD
Sbjct: 344 SPLILATASASWNIVNLLLSKGAQVDIKDNF----------------------------- 374
Query: 264 SPGTGVSTSSVSLLQGGNTALHLAAKHGHS-PAVQVLLAQWQDINE--MNELN--ISSLQ 318
G LHL + + ++ Q Q I E M+E N + L
Sbjct: 375 ----------------GRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLH 418
Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
A R G VN LL NV +H K + K+SPLH I LL D +LN+
Sbjct: 419 YACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEG 478
Query: 379 Q---QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
TPLH+AA G+ ++V+ LLK G L D G TAL AS ++ + +++
Sbjct: 479 DLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVIL 534
Score = 86.7 bits (213), Expect = 5e-17
Identities = 105/443 (23%), Positives = 179/443 (40%), Gaps = 73/443 (16%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKA-RVDVADKH 133
A + N ++ ++ L + N N+ N LH AV + + LL+H+ V++ ++
Sbjct: 105 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGEN 164
Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLI------ 187
G T + +A + + E + +L+K GA N+ G +H A S +E ++
Sbjct: 165 GNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEH 224
Query: 188 ---QDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAAL 244
+ LH+ +N P LA + G +EMI+ +K + + + AA
Sbjct: 225 GYSRQLHINFMNNGK---ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAA- 280
Query: 245 TKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG-GNTALHLAAKHGHSPAVQVLLAQW 303
T+ T + + G S V+ G T LH A+ H L++
Sbjct: 281 TQGATEIVKLMISSYSG--------SVDIVNTTDGCHETMLHRASLFDHHELADYLISVG 332
Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVD-----------LHQKVEP------- 345
DIN+++ S L +AT + ++VN LLS+ LH V+
Sbjct: 333 ADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNL 392
Query: 346 ----------KE----------SPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHV 385
KE +PLH VN+LL I ++ +++PLH
Sbjct: 393 RPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHF 452
Query: 386 AADRGNVELVETLLKAGCDLKAV---DKQGKTALAVASRSNHSLVVGMLIKAERYY---- 438
AA G + + LL+ D + + D G T L +A+++ H VV +L+K +
Sbjct: 453 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH 512
Query: 439 -AWREEHHESIRDPSTGFTLTFK 460
W HH S+ G+T T K
Sbjct: 513 NGWTALHHASM----GGYTQTMK 531
Score = 79.7 bits (195), Expect = 6e-15
Identities = 70/345 (20%), Positives = 149/345 (43%), Gaps = 11/345 (3%)
Query: 88 FEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKAR--VDVADKHGLTVIHLAAWSG 145
F K+ + ++M+ LH+A + ++ + + + + D +G T +H A
Sbjct: 50 FNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKN 109
Query: 146 SLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKP 205
+E + L+ GA+ +N + M+ LH A Q + +++ L++ + D+N E G
Sbjct: 110 QIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTI-DVNLEGENGNTA 168
Query: 206 FLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSP 265
++A + E ++ L + +K + AA + K I E S
Sbjct: 169 VIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSR 228
Query: 266 GTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGH 325
++ + G T LHLA ++G +++ L I+ + + +++ A G
Sbjct: 229 QLHINFMN----NGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGA 284
Query: 326 ASLVNFLLSE---NVDLHQKVEP-KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQT 381
+V ++S +VD+ + E+ LH + +H + + L+S DI+ ++ + ++
Sbjct: 285 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRS 344
Query: 382 PLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSL 426
PL +A + +V LL G + D G+ L + + + L
Sbjct: 345 PLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL 389
Score = 71.2 bits (173), Expect = 2e-12
Identities = 83/357 (23%), Positives = 141/357 (39%), Gaps = 63/357 (17%)
Query: 68 NERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV 127
+E A+ ++ +L + L +IN +++ R+ L A + V+ LL A+V
Sbjct: 309 HETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQV 368
Query: 128 DV--------------------------------------ADKHGLTVIHLAAWSGSLEV 149
D+ D G T +H A G
Sbjct: 369 DIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGS 428
Query: 150 MLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL-HLKDLNQPDEKGRKPFLL 208
+ L+ +K++D S LHFA + + L+QD+ + LN+ D G P L
Sbjct: 429 VNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHL 488
Query: 209 AAERGHVEMIEKL-----TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGAC 263
AA+ GH ++++ L FL+ H W+ L A++ + I ++ C
Sbjct: 489 AAKNGHDKVVQLLLKKGALFLSDHNG------WTALHHASMGGYTQTMKVILDTNLK--C 540
Query: 264 SPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRN 323
+ L + GNTALH AA+ GH+ AV +LL+ DI +N+ S L +A N
Sbjct: 541 TD---------RLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHN 590
Query: 324 GHASLV-NFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ 379
+V + S+ D K+ SP + I I + + D +L+ +
Sbjct: 591 KRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTE 647
Score = 48.5 bits (114), Expect = 1e-05
Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 1/96 (1%)
Query: 339 LHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETL 398
LH+ + +PLH V N I V LLS + ++ N PLH+A N E+++ L
Sbjct: 91 LHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVL 150
Query: 399 LK-AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
L+ D+ + G TA+ +A +N+S + +L+K
Sbjct: 151 LEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 103 bits (257), Expect = 4e-22
Identities = 95/373 (25%), Positives = 161/373 (43%), Gaps = 43/373 (11%)
Query: 83 LMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAA 142
+ E L K NIN T LH A + H V+ ++KH+A+V+ D G T +H AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441
Query: 143 WSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKG 202
+ G L+ +L+ G D + G +AL ++ +Q L + ++ + +
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN---------VQQLLQEGISLGNSEA 492
Query: 203 RKPFLLAAERGHVEMIEKL-TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEG 261
+ L AA+ G VE ++KL T +++ + + Q + L AA N ++ +E
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAA------GYNRVSV--VEY 544
Query: 262 ACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIAT 321
G V +GG LH A +GH ++L+ +N + + L A
Sbjct: 545 LLQHGADVHAKD----KGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600
Query: 322 RNGHASLVNFLLSENVDLHQKVEPKESPLHLV---------VINNHITVVNSL------- 365
G + LL D +K +PL LV ++ ++++
Sbjct: 601 AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR 660
Query: 366 ---LSAQHDIDILNQ--KQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
LS+ +++ + + TPLH+AA N+E+ E LL+ G D+ A DK G L A+
Sbjct: 661 VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA 720
Query: 421 RSNHSLVVGMLIK 433
H V +LIK
Sbjct: 721 SYGHVDVAALLIK 733
Score = 97.1 bits (240), Expect = 4e-20
Identities = 108/408 (26%), Positives = 155/408 (37%), Gaps = 57/408 (13%)
Query: 73 QNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADK 132
++A N +M L VN + + T LH A G N + V LL+H A V DK
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242
Query: 133 HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ---- 188
L +H A G EV +LVK GA A + + LH A N V + L+
Sbjct: 243 GDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302
Query: 189 ------------DL----HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKD 232
DL LK+ + KG L AA V I+K L + +
Sbjct: 303 PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS-LLQAAREADVTRIKKHLSLEMVNFKHP 361
Query: 233 KIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGH 292
+ + L AA + R I L + G ++ + L T LH+A++ H
Sbjct: 362 QTHETALHCAAASPY-PKRKQICELLLR----KGANINEKTKEFL----TPLHVASEKAH 412
Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVD-----------LHQ 341
+ V+V++ +N ++ L +SL A GH LLS D L
Sbjct: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM 472
Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDI----------------LNQKQQTPLHV 385
E + L + + LL A D+ + +Q TPLH
Sbjct: 473 GNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHF 532
Query: 386 AADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
AA V +VE LL+ G D+ A DK G L A H V +L+K
Sbjct: 533 AAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVK 580
Score = 90.1 bits (222), Expect = 4e-18
Identities = 85/322 (26%), Positives = 136/322 (42%), Gaps = 28/322 (8%)
Query: 69 ERSFQNAAKSNNLDLMEKLFE-KKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV 127
+R AAK+ +++ ++KL + VN + T LHFA G N +S V++LL+H A V
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 128 DVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLI 187
DK GL +H A G EV +LVK GA + + LH A I + L+
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Query: 188 QDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
Q H D + + G P L + G ++ + L + + + A K
Sbjct: 613 Q--HGADPTKKNRDGNTPLDLVKD-GDTDIQDLL------RGDAALLDAAKKGCLARVKK 663
Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
+S +++ +G S T LHLAA + + + LL D+N
Sbjct: 664 LSSPDNVNCRDTQGRHS-----------------TPLHLAAGYNNLEVAEYLLQHGADVN 706
Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
++ + L A GH + L+ N ++ + +PLH + LL+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766
Query: 368 AQHDIDILNQKQQTPLH-VAAD 388
D + NQ+ QTPL V+AD
Sbjct: 767 HGADPTLKNQEGQTPLDLVSAD 788
Score = 84.3 bits (207), Expect = 2e-16
Identities = 90/396 (22%), Positives = 163/396 (41%), Gaps = 50/396 (12%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
A++ + D++E + + + +N ++N+ +T+LH A HL LL + ++ G
Sbjct: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466
Query: 135 LTVIHL--------------------------AAWSGSLEVMLMLVKAGADQRAKNQDGM 168
T + + AA +G +E + L + ++ +G
Sbjct: 467 FTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGR 525
Query: 169 SA--LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNL 226
+ LHFA N V +VEYL+Q H D++ D+ G P A GH E+ E L
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQ--HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583
Query: 227 HTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSL---------- 276
+ D +++ L AA + I L ++ P + L
Sbjct: 584 VVNVADLWKFTPLHEAAAK----GKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI 639
Query: 277 --LQGGNTALHLAAKHGHSPAVQVLLAQWQDIN--EMNELNISSLQIATRNGHASLVNFL 332
L G+ AL AAK G V+ L + ++N + + + L +A + + +L
Sbjct: 640 QDLLRGDAALLDAAKKGCLARVKKLSSP-DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYL 698
Query: 333 LSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNV 392
L D++ + + PLH H+ V L+ ++ ++ TPLH AA +G
Sbjct: 699 LQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRT 758
Query: 393 ELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVV 428
+L LL G D +++G+T L + S + S ++
Sbjct: 759 QLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794
Score = 84.0 bits (206), Expect = 3e-16
Identities = 107/422 (25%), Positives = 168/422 (39%), Gaps = 56/422 (13%)
Query: 58 AVAGHELLLPNERSFQNAAKSNNLDLMEKLFE-KKVNINVVNNMNRTALHFAVGRNHLSA 116
A A E + P R A ++ +++ +++L +KVN T LHFA G
Sbjct: 14 ASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDV 73
Query: 117 VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQ 176
V++LL++ A V D GL +H A G EV+ +L++ GAD A++ + LH A
Sbjct: 74 VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAI 133
Query: 177 SNHVRIVEYLIQ-----------DLHLKDLNQPDEKG------RKPFLLAAERGHVE--M 217
+ + L+Q DL P K +K LL + R E M
Sbjct: 134 KGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKM 193
Query: 218 IEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLL 277
+ LT LN++ D + + L AA +R I L ++ G V
Sbjct: 194 MALLTPLNVNCHASDGRKSTPLHLAA----GYNRVKIVQLLLQ----HGADVHAKD---- 241
Query: 278 QGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENV 337
+G LH A +GH ++L+ +N M+ + L A + + LLS
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301
Query: 338 D-----LHQKVEPKESPL-HLVVINNHITVVNSLLSAQHDIDILN--------------- 376
D H K +P L + +SLL A + D+
Sbjct: 302 DPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHP 361
Query: 377 QKQQTPLHVAADR---GNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
Q +T LH AA ++ E LL+ G ++ K+ T L VAS H+ VV +++K
Sbjct: 362 QTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421
Query: 434 AE 435
E
Sbjct: 422 HE 423
Score = 75.1 bits (183), Expect = 1e-13
Identities = 93/418 (22%), Positives = 163/418 (38%), Gaps = 82/418 (19%)
Query: 75 AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
AA N + +++ L + +++ + + LH A H + L+KH A V+ D
Sbjct: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277
Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA----------------------LH 172
T +H AA +EV +L+ GAD N SA L
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 173 FATQSNHVRIVEYL------------------------------IQDLHLK---DLNQPD 199
A +++ RI ++L I +L L+ ++N+
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-KMKTSRNSIAALT 258
++ P +A+E+ H +++E + + D + ++L AA ++T R L
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR-----LL 452
Query: 259 IEGACSPGTGVSTSSVSLLQGGNTALHLAAKHG----HSPAVQVLL--AQWQDINEMNEL 312
+ C P +S + LQ GN + + G +S A + LL A+ D+ + +L
Sbjct: 453 LSYGCDPNI-ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKL 511
Query: 313 --------------NISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH 358
+ L A S+V +LL D+H K + PLH H
Sbjct: 512 CTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGH 571
Query: 359 ITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTAL 416
V L+ +++ + + TPLH AA +G E+ + LL+ G D ++ G T L
Sbjct: 572 YEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629
Score = 67.4 bits (163), Expect = 3e-11
Identities = 74/316 (23%), Positives = 126/316 (39%), Gaps = 23/316 (7%)
Query: 65 LLPNERSFQNAAKSNNLDLMEKLFEK-KVNINVVNNMNRTALHFAVGRNHLSAVDFLLKH 123
LL + + +AAK L ++KL VN + T LH A G N+L ++LL+H
Sbjct: 642 LLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH 701
Query: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
A V+ DK GL +H AA G ++V +L+K A A ++ + LH A Q ++
Sbjct: 702 GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLC 761
Query: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA 243
L+ H D +++G+ P ++++ L T+ + +
Sbjct: 762 ALLL--AHGADPTLKNQEGQTP---------LDLVSADDVSALLTAAMPPSALPSCYKPQ 810
Query: 244 LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQW 303
+ S + A G SP + + SS+ L G + L + L
Sbjct: 811 VLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSL---- 866
Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH----- 358
+ E+ ++ S Q G L++ E + L VE L + IN +
Sbjct: 867 -EKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHK 925
Query: 359 -ITVVNSLLSAQHDID 373
I V L+S Q ++
Sbjct: 926 LIKGVERLISGQQGLN 941
Score = 53.9 bits (128), Expect = 3e-07
Identities = 45/185 (24%), Positives = 81/185 (43%), Gaps = 3/185 (1%)
Query: 266 GTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISS--LQIATRN 323
G ++++ ++ L A ++G V+ L+ + +N + S L A
Sbjct: 10 GAACASAAAEAVEPAARELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGF 68
Query: 324 GHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPL 383
G +V +LL ++ + + PLH H VVN LL D + + TPL
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 384 HVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREE 443
H AA +G +++ LL+ G + + G+TAL +A S +++ G K E + R
Sbjct: 129 HEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSG 188
Query: 444 HHESI 448
+ E +
Sbjct: 189 NEEKM 193
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 102 bits (255), Expect = 7e-22
Identities = 90/352 (25%), Positives = 141/352 (40%), Gaps = 54/352 (15%)
Query: 83 LMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAA 142
L+ +L + ++ ++ RT LH AV R H V LL+ A V D+ G T +H AA
Sbjct: 56 LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115
Query: 143 WSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKG 202
W G V +L++ GA A++ G++ LH+A H + L++ G
Sbjct: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE-----------APG 164
Query: 203 RKPFLLAAE--RGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIE 260
P AE RG WTAA R ++ L
Sbjct: 165 PGPAAAEAEDARG--------------------------WTAAHWAAAGGRLAVLELLAA 198
Query: 261 GACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIA 320
G G + AL +AA G A++ LLA+ ++ + ++L +A
Sbjct: 199 GGA---------------GLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243
Query: 321 TRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQ 380
G + + LL D + S LH H+ V L++ ++D +
Sbjct: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303
Query: 381 TPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
TPLH A+ G+VE+ LL G + A KT L +A+ H VG+L+
Sbjct: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLL 355
Score = 57.0 bits (136), Expect = 4e-08
Identities = 35/115 (30%), Positives = 55/115 (47%)
Query: 320 ATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ 379
A G A LV LL + + ++ +PLHL V+ H +V LL + +++
Sbjct: 48 AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107
Query: 380 QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
+T LH AA G+ + E LL+ G A G T L A+ H+L+ L++A
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
Score = 38.5 bits (88), Expect = 0.015
Identities = 45/175 (25%), Positives = 69/175 (39%), Gaps = 28/175 (16%)
Query: 11 GATAGGLLLRAAAAAKGLREDLWGAAALPWRSL--SRIPKREGLGEEDTAVAGH------ 62
GA G LL AAAA +G AAL + +R+ R+G G +A
Sbjct: 200 GAGLDGALLVAAAAGRG--------AALRFLLARGARVDARDGAGATALGLAAALGRSQD 251
Query: 63 -ELLLPN-----------ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVG 110
E+LL + + AA +L ++ L + ++ + + T LH A
Sbjct: 252 IEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASR 311
Query: 111 RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQ 165
H+ LL A+VD T +HLAA G + +L+ GA + Q
Sbjct: 312 EGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.130 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,489,578
Number of Sequences: 37866
Number of extensions: 750551
Number of successful extensions: 7249
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 356
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 1986
Number of HSP's gapped (non-prelim): 2531
length of query: 524
length of database: 18,247,518
effective HSP length: 107
effective length of query: 417
effective length of database: 14,195,856
effective search space: 5919671952
effective search space used: 5919671952
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.