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Search of human proteins with 239752049
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239752049 PREDICTED: ankyrin repeat domain 60 [Homo sapiens]
(337 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239757533 PREDICTED: ankyrin repeat domain 60 [Homo sapiens] 685 0.0
gi|239752049 PREDICTED: ankyrin repeat domain 60 [Homo sapiens] 685 0.0
gi|239746532 PREDICTED: ankyrin repeat domain 60 [Homo sapiens] 681 0.0
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 69 8e-12
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 69 8e-12
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 69 8e-12
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 69 8e-12
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 69 8e-12
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 62 7e-10
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 61 2e-09
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 60 2e-09
gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens] 59 5e-09
gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens] 59 5e-09
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 59 6e-09
gi|20270347 ankyrin repeat domain 54 [Homo sapiens] 59 6e-09
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 58 1e-08
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 58 1e-08
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 58 1e-08
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 58 1e-08
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 56 5e-08
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 55 7e-08
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 55 7e-08
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 55 9e-08
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 55 1e-07
gi|156142184 ankyrin repeat domain 39 [Homo sapiens] 55 1e-07
gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens] 54 2e-07
gi|41350198 fetal globin inducing factor [Homo sapiens] 54 2e-07
gi|8051593 GA binding protein transcription factor, beta subunit... 54 2e-07
gi|8051595 GA binding protein transcription factor, beta subunit... 54 2e-07
gi|32483404 GA binding protein transcription factor, beta subuni... 54 2e-07
>gi|239757533 PREDICTED: ankyrin repeat domain 60 [Homo sapiens]
Length = 337
Score = 685 bits (1768), Expect = 0.0
Identities = 337/337 (100%), Positives = 337/337 (100%)
Query: 1 MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC 60
MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC
Sbjct: 1 MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC 60
Query: 61 ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM 120
ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM
Sbjct: 61 ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM 120
Query: 121 VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL 180
VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL
Sbjct: 121 VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL 180
Query: 181 SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS 240
SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS
Sbjct: 181 SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS 240
Query: 241 RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLL 300
RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLL
Sbjct: 241 RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLL 300
Query: 301 HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH 337
HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH
Sbjct: 301 HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH 337
>gi|239752049 PREDICTED: ankyrin repeat domain 60 [Homo sapiens]
Length = 337
Score = 685 bits (1768), Expect = 0.0
Identities = 337/337 (100%), Positives = 337/337 (100%)
Query: 1 MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC 60
MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC
Sbjct: 1 MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC 60
Query: 61 ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM 120
ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM
Sbjct: 61 ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM 120
Query: 121 VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL 180
VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL
Sbjct: 121 VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL 180
Query: 181 SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS 240
SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS
Sbjct: 181 SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS 240
Query: 241 RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLL 300
RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLL
Sbjct: 241 RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLL 300
Query: 301 HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH 337
HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH
Sbjct: 301 HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH 337
>gi|239746532 PREDICTED: ankyrin repeat domain 60 [Homo sapiens]
Length = 345
Score = 681 bits (1756), Expect = 0.0
Identities = 336/337 (99%), Positives = 336/337 (99%)
Query: 1 MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC 60
MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC
Sbjct: 9 MRRAAAGAGGARAAGPTGGASRLHPNAGRRSGARAGAQGCGGPRVGSADSRALPAQPLAC 68
Query: 61 ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM 120
ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM
Sbjct: 69 ARGRSQRLVCDPKAASALPDLAPDVFVLRVRLEETGEMFRVANCRGDMTVRELKEELDLM 128
Query: 121 VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL 180
VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL
Sbjct: 129 VGIPFNLQRLQYLDEGVLMDDTTLKFHDVVPGGIISLCIWHHDGWTELVLAAVEGDPSKL 188
Query: 181 SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS 240
SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS
Sbjct: 189 SCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLS 248
Query: 241 RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLL 300
RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAH LNHTLSERQMVLL
Sbjct: 249 RSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHRLNHTLSERQMVLL 308
Query: 301 HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH 337
HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH
Sbjct: 309 HRIAKSGIRDLNDLVMKNALQRVKSGFRSEKMTMTPH 345
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 68.6 bits (166), Expect = 8e-12
Identities = 33/83 (39%), Positives = 55/83 (66%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ + L+VASH G+ V++LL+H A +++ LG +PLH AA G +D + LLL++
Sbjct: 730 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 789
Query: 268 GASIHDRDAKGETPISIAHCLNH 290
GAS ++ + G TP++IA L +
Sbjct: 790 GASPNEVSSDGTTPLAIAKRLGY 812
Score = 61.6 bits (148), Expect = 9e-10
Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + LL+HGA +++ G +P+H+AA DC+ LLLQ+ A I D
Sbjct: 309 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 368
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
TP+ + AHC +H +++ VLL + AK R LN
Sbjct: 369 LDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALN 403
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + H ++ LL+ GAS + + G TPLHVA+ MG + LLQ GAS +
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNALQRV 323
+ K ETP+ +A HT E LL AK + +D + R+
Sbjct: 465 VSNVKVETPLHMAARAGHT--EVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/75 (40%), Positives = 41/75 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA+H GH + LL+ GA SR+ G TPLH+A + LLL+ GASI
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 276 AKGETPISIAHCLNH 290
G TP+ +A + H
Sbjct: 435 ESGLTPLHVASFMGH 449
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/80 (36%), Positives = 43/80 (53%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
++T Q L++AS RG+ V+ LL+ GA +++ TPLH AA G +LL
Sbjct: 266 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 325
Query: 266 QHGASIHDRDAKGETPISIA 285
HGA I + G +PI +A
Sbjct: 326 DHGAPIQAKTKNGLSPIHMA 345
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/89 (32%), Positives = 51/89 (57%), Gaps = 2/89 (2%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH + +YLL++ A +++ +TPLH AA +G ++ + LLL++ A+ +
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 533
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA 304
G TP+ IA H E + LL + A
Sbjct: 534 TAGHTPLHIAAREGHV--ETVLALLEKEA 560
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 8/103 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA H + D V+ LL G S S + G TPLH+AA + + LLQ+G S +
Sbjct: 606 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 665
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLN 312
+G TP+ +A H +E +LL + A KSG+ L+
Sbjct: 666 VQGVTPLHLAAQEGH--AEMVALLLSKQANGNLGNKSGLTPLH 706
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/83 (33%), Positives = 44/83 (53%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ L+VAS GH V+ LL+ GAS + TPLH+AA G ++ LLQ+
Sbjct: 434 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493
Query: 269 ASIHDRDAKGETPISIAHCLNHT 291
A ++ + +TP+ A + HT
Sbjct: 494 AKVNAKAKDDQTPLHCAARIGHT 516
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 18/103 (17%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++ + GH L++HG + + +G TPLHVA+ G + LLQH A ++ +
Sbjct: 705 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 764
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKN 318
G +P LH+ A+ G D+ L++KN
Sbjct: 765 KLGYSP------------------LHQAAQQGHTDIVTLLLKN 789
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/115 (33%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + V+ LLE+ A+ + G TPLH+AA G + ++ LL+ AS
Sbjct: 507 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 566
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLNDLVMKNALQRVK 324
KG TP+ +A + +LL R A K+G+ L+ V N L VK
Sbjct: 567 KKGFTPLHVA--AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619
Score = 47.8 bits (112), Expect = 1e-05
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A S +H + +Q L++AS GH V LL +
Sbjct: 48 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+AA G+ + + L+ +GA+++ + KG TP+ +A NH
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 156
Score = 47.8 bits (112), Expect = 1e-05
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
S+ F L++A+H + + Q LL GAS G TPLH+A+ G + LLL G
Sbjct: 236 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 295
Query: 269 ASIHDRDAKGETPISIAHC 287
A I + TP+ HC
Sbjct: 296 AQIETKTKDELTPL---HC 311
Score = 47.0 bits (110), Expect = 2e-05
Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 17/135 (12%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
+++A+ H D V+ LL++ A + TPLHVAA G +LL GA + R
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHR-------IAKSGIRDLNDL-------VMKNALQ 321
G TP+ IA NH R M LL + + +SG+ L+ ++KN LQ
Sbjct: 402 LNGFTPLHIACKKNHV---RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 458
Query: 322 RVKSGFRSEKMTMTP 336
R S S TP
Sbjct: 459 RGASPNVSNVKVETP 473
Score = 46.6 bits (109), Expect = 3e-05
Identities = 24/78 (30%), Positives = 48/78 (61%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+++ AL++A+ G + V+ L+ +GA+ ++S G TPL++AA + + LL++
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 268 GASIHDRDAKGETPISIA 285
GA+ + G TP+++A
Sbjct: 167 GANQNVATEDGFTPLAVA 184
Score = 46.6 bits (109), Expect = 3e-05
Identities = 30/90 (33%), Positives = 41/90 (45%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G + LLE A + G TPLHVA D + LLL G
Sbjct: 566 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 625
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMV 298
S H G TP+ IA N R ++
Sbjct: 626 GSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655
Score = 45.1 bits (105), Expect = 9e-05
Identities = 22/60 (36%), Positives = 35/60 (58%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ+ F LY+A+ H + V++LLE+GA+ + G TPL VA G + + L+ +G
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Score = 45.1 bits (105), Expect = 9e-05
Identities = 23/79 (29%), Positives = 43/79 (54%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H + + L++A+ + + + LL++G S + S G TPLH+AA G ++ + LLL
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Query: 266 QHGASIHDRDAKGETPISI 284
A+ + + G TP+ +
Sbjct: 689 SKQANGNLGNKSGLTPLHL 707
Score = 38.9 bits (89), Expect = 0.007
Identities = 40/160 (25%), Positives = 62/160 (38%), Gaps = 38/160 (23%)
Query: 191 YRTANSEHFEGEKW-------KHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSP 243
Y A H E K+ ++ ++ F L VA +GH + V +L+ +G R P
Sbjct: 149 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 208
Query: 244 L-----------------------------GRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
G TPLH+AA + LLL GAS++
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268
Query: 275 DAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDL 314
G TP+ IA + + R +LL R A+ + ++L
Sbjct: 269 PQNGITPLHIASRRGNVIMVR--LLLDRGAQIETKTKDEL 306
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 68.6 bits (166), Expect = 8e-12
Identities = 33/83 (39%), Positives = 55/83 (66%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ + L+VASH G+ V++LL+H A +++ LG +PLH AA G +D + LLL++
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 268 GASIHDRDAKGETPISIAHCLNH 290
GAS ++ + G TP++IA L +
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGY 779
Score = 61.6 bits (148), Expect = 9e-10
Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + LL+HGA +++ G +P+H+AA DC+ LLLQ+ A I D
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
TP+ + AHC +H +++ VLL + AK R LN
Sbjct: 336 LDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALN 370
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + H ++ LL+ GAS + + G TPLHVA+ MG + LLQ GAS +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNALQRV 323
+ K ETP+ +A HT E LL AK + +D + R+
Sbjct: 432 VSNVKVETPLHMAARAGHT--EVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/75 (40%), Positives = 41/75 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA+H GH + LL+ GA SR+ G TPLH+A + LLL+ GASI
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 276 AKGETPISIAHCLNH 290
G TP+ +A + H
Sbjct: 402 ESGLTPLHVASFMGH 416
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/80 (36%), Positives = 43/80 (53%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
++T Q L++AS RG+ V+ LL+ GA +++ TPLH AA G +LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 266 QHGASIHDRDAKGETPISIA 285
HGA I + G +PI +A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMA 312
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/89 (32%), Positives = 51/89 (57%), Gaps = 2/89 (2%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH + +YLL++ A +++ +TPLH AA +G ++ + LLL++ A+ +
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA 304
G TP+ IA H E + LL + A
Sbjct: 501 TAGHTPLHIAAREGHV--ETVLALLEKEA 527
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 8/103 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA H + D V+ LL G S S + G TPLH+AA + + LLQ+G S +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLN 312
+G TP+ +A H +E +LL + A KSG+ L+
Sbjct: 633 VQGVTPLHLAAQEGH--AEMVALLLSKQANGNLGNKSGLTPLH 673
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/83 (33%), Positives = 44/83 (53%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ L+VAS GH V+ LL+ GAS + TPLH+AA G ++ LLQ+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 269 ASIHDRDAKGETPISIAHCLNHT 291
A ++ + +TP+ A + HT
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHT 483
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 18/103 (17%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++ + GH L++HG + + +G TPLHVA+ G + LLQH A ++ +
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKN 318
G +P LH+ A+ G D+ L++KN
Sbjct: 732 KLGYSP------------------LHQAAQQGHTDIVTLLLKN 756
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/115 (33%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + V+ LLE+ A+ + G TPLH+AA G + ++ LL+ AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLNDLVMKNALQRVK 324
KG TP+ +A + +LL R A K+G+ L+ V N L VK
Sbjct: 534 KKGFTPLHVA--AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Score = 47.8 bits (112), Expect = 1e-05
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A S +H + +Q L++AS GH V LL +
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+AA G+ + + L+ +GA+++ + KG TP+ +A NH
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Score = 47.8 bits (112), Expect = 1e-05
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
S+ F L++A+H + + Q LL GAS G TPLH+A+ G + LLL G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 269 ASIHDRDAKGETPISIAHC 287
A I + TP+ HC
Sbjct: 263 AQIETKTKDELTPL---HC 278
Score = 47.0 bits (110), Expect = 2e-05
Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 17/135 (12%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
+++A+ H D V+ LL++ A + TPLHVAA G +LL GA + R
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHR-------IAKSGIRDLNDL-------VMKNALQ 321
G TP+ IA NH R M LL + + +SG+ L+ ++KN LQ
Sbjct: 369 LNGFTPLHIACKKNHV---RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 322 RVKSGFRSEKMTMTP 336
R S S TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 46.6 bits (109), Expect = 3e-05
Identities = 24/78 (30%), Positives = 48/78 (61%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+++ AL++A+ G + V+ L+ +GA+ ++S G TPL++AA + + LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 268 GASIHDRDAKGETPISIA 285
GA+ + G TP+++A
Sbjct: 134 GANQNVATEDGFTPLAVA 151
Score = 46.6 bits (109), Expect = 3e-05
Identities = 30/90 (33%), Positives = 41/90 (45%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G + LLE A + G TPLHVA D + LLL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMV 298
S H G TP+ IA N R ++
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Score = 45.1 bits (105), Expect = 9e-05
Identities = 22/60 (36%), Positives = 35/60 (58%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ+ F LY+A+ H + V++LLE+GA+ + G TPL VA G + + L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 45.1 bits (105), Expect = 9e-05
Identities = 23/79 (29%), Positives = 43/79 (54%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H + + L++A+ + + + LL++G S + S G TPLH+AA G ++ + LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 266 QHGASIHDRDAKGETPISI 284
A+ + + G TP+ +
Sbjct: 656 SKQANGNLGNKSGLTPLHL 674
Score = 38.9 bits (89), Expect = 0.007
Identities = 40/160 (25%), Positives = 62/160 (38%), Gaps = 38/160 (23%)
Query: 191 YRTANSEHFEGEKW-------KHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSP 243
Y A H E K+ ++ ++ F L VA +GH + V +L+ +G R P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 244 L-----------------------------GRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
G TPLH+AA + LLL GAS++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 275 DAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDL 314
G TP+ IA + + R +LL R A+ + ++L
Sbjct: 236 PQNGITPLHIASRRGNVIMVR--LLLDRGAQIETKTKDEL 273
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 68.6 bits (166), Expect = 8e-12
Identities = 33/83 (39%), Positives = 55/83 (66%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ + L+VASH G+ V++LL+H A +++ LG +PLH AA G +D + LLL++
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 268 GASIHDRDAKGETPISIAHCLNH 290
GAS ++ + G TP++IA L +
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGY 779
Score = 61.6 bits (148), Expect = 9e-10
Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + LL+HGA +++ G +P+H+AA DC+ LLLQ+ A I D
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
TP+ + AHC +H +++ VLL + AK R LN
Sbjct: 336 LDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALN 370
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + H ++ LL+ GAS + + G TPLHVA+ MG + LLQ GAS +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNALQRV 323
+ K ETP+ +A HT E LL AK + +D + R+
Sbjct: 432 VSNVKVETPLHMAARAGHT--EVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/75 (40%), Positives = 41/75 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA+H GH + LL+ GA SR+ G TPLH+A + LLL+ GASI
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 276 AKGETPISIAHCLNH 290
G TP+ +A + H
Sbjct: 402 ESGLTPLHVASFMGH 416
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/80 (36%), Positives = 43/80 (53%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
++T Q L++AS RG+ V+ LL+ GA +++ TPLH AA G +LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 266 QHGASIHDRDAKGETPISIA 285
HGA I + G +PI +A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMA 312
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/89 (32%), Positives = 51/89 (57%), Gaps = 2/89 (2%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH + +YLL++ A +++ +TPLH AA +G ++ + LLL++ A+ +
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA 304
G TP+ IA H E + LL + A
Sbjct: 501 TAGHTPLHIAAREGHV--ETVLALLEKEA 527
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 8/103 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA H + D V+ LL G S S + G TPLH+AA + + LLQ+G S +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLN 312
+G TP+ +A H +E +LL + A KSG+ L+
Sbjct: 633 VQGVTPLHLAAQEGH--AEMVALLLSKQANGNLGNKSGLTPLH 673
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/83 (33%), Positives = 44/83 (53%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ L+VAS GH V+ LL+ GAS + TPLH+AA G ++ LLQ+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 269 ASIHDRDAKGETPISIAHCLNHT 291
A ++ + +TP+ A + HT
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHT 483
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 18/103 (17%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++ + GH L++HG + + +G TPLHVA+ G + LLQH A ++ +
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKN 318
G +P LH+ A+ G D+ L++KN
Sbjct: 732 KLGYSP------------------LHQAAQQGHTDIVTLLLKN 756
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/115 (33%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + V+ LLE+ A+ + G TPLH+AA G + ++ LL+ AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLNDLVMKNALQRVK 324
KG TP+ +A + +LL R A K+G+ L+ V N L VK
Sbjct: 534 KKGFTPLHVA--AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Score = 47.8 bits (112), Expect = 1e-05
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A S +H + +Q L++AS GH V LL +
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+AA G+ + + L+ +GA+++ + KG TP+ +A NH
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Score = 47.8 bits (112), Expect = 1e-05
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
S+ F L++A+H + + Q LL GAS G TPLH+A+ G + LLL G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 269 ASIHDRDAKGETPISIAHC 287
A I + TP+ HC
Sbjct: 263 AQIETKTKDELTPL---HC 278
Score = 47.0 bits (110), Expect = 2e-05
Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 17/135 (12%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
+++A+ H D V+ LL++ A + TPLHVAA G +LL GA + R
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHR-------IAKSGIRDLNDL-------VMKNALQ 321
G TP+ IA NH R M LL + + +SG+ L+ ++KN LQ
Sbjct: 369 LNGFTPLHIACKKNHV---RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 322 RVKSGFRSEKMTMTP 336
R S S TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 46.6 bits (109), Expect = 3e-05
Identities = 24/78 (30%), Positives = 48/78 (61%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+++ AL++A+ G + V+ L+ +GA+ ++S G TPL++AA + + LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 268 GASIHDRDAKGETPISIA 285
GA+ + G TP+++A
Sbjct: 134 GANQNVATEDGFTPLAVA 151
Score = 46.6 bits (109), Expect = 3e-05
Identities = 30/90 (33%), Positives = 41/90 (45%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G + LLE A + G TPLHVA D + LLL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMV 298
S H G TP+ IA N R ++
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Score = 45.1 bits (105), Expect = 9e-05
Identities = 22/60 (36%), Positives = 35/60 (58%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ+ F LY+A+ H + V++LLE+GA+ + G TPL VA G + + L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 45.1 bits (105), Expect = 9e-05
Identities = 23/79 (29%), Positives = 43/79 (54%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H + + L++A+ + + + LL++G S + S G TPLH+AA G ++ + LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 266 QHGASIHDRDAKGETPISI 284
A+ + + G TP+ +
Sbjct: 656 SKQANGNLGNKSGLTPLHL 674
Score = 38.9 bits (89), Expect = 0.007
Identities = 40/160 (25%), Positives = 62/160 (38%), Gaps = 38/160 (23%)
Query: 191 YRTANSEHFEGEKW-------KHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSP 243
Y A H E K+ ++ ++ F L VA +GH + V +L+ +G R P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 244 L-----------------------------GRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
G TPLH+AA + LLL GAS++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 275 DAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDL 314
G TP+ IA + + R +LL R A+ + ++L
Sbjct: 236 PQNGITPLHIASRRGNVIMVR--LLLDRGAQIETKTKDEL 273
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 68.6 bits (166), Expect = 8e-12
Identities = 33/83 (39%), Positives = 55/83 (66%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ + L+VASH G+ V++LL+H A +++ LG +PLH AA G +D + LLL++
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 268 GASIHDRDAKGETPISIAHCLNH 290
GAS ++ + G TP++IA L +
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGY 779
Score = 61.6 bits (148), Expect = 9e-10
Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + LL+HGA +++ G +P+H+AA DC+ LLLQ+ A I D
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
TP+ + AHC +H +++ VLL + AK R LN
Sbjct: 336 LDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALN 370
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + H ++ LL+ GAS + + G TPLHVA+ MG + LLQ GAS +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNALQRV 323
+ K ETP+ +A HT E LL AK + +D + R+
Sbjct: 432 VSNVKVETPLHMAARAGHT--EVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/75 (40%), Positives = 41/75 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA+H GH + LL+ GA SR+ G TPLH+A + LLL+ GASI
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 276 AKGETPISIAHCLNH 290
G TP+ +A + H
Sbjct: 402 ESGLTPLHVASFMGH 416
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/80 (36%), Positives = 43/80 (53%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
++T Q L++AS RG+ V+ LL+ GA +++ TPLH AA G +LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 266 QHGASIHDRDAKGETPISIA 285
HGA I + G +PI +A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMA 312
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/89 (32%), Positives = 51/89 (57%), Gaps = 2/89 (2%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH + +YLL++ A +++ +TPLH AA +G ++ + LLL++ A+ +
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA 304
G TP+ IA H E + LL + A
Sbjct: 501 TAGHTPLHIAAREGHV--ETVLALLEKEA 527
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 8/103 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA H + D V+ LL G S S + G TPLH+AA + + LLQ+G S +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLN 312
+G TP+ +A H +E +LL + A KSG+ L+
Sbjct: 633 VQGVTPLHLAAQEGH--AEMVALLLSKQANGNLGNKSGLTPLH 673
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/83 (33%), Positives = 44/83 (53%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ L+VAS GH V+ LL+ GAS + TPLH+AA G ++ LLQ+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 269 ASIHDRDAKGETPISIAHCLNHT 291
A ++ + +TP+ A + HT
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHT 483
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 18/103 (17%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++ + GH L++HG + + +G TPLHVA+ G + LLQH A ++ +
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKN 318
G +P LH+ A+ G D+ L++KN
Sbjct: 732 KLGYSP------------------LHQAAQQGHTDIVTLLLKN 756
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/115 (33%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + V+ LLE+ A+ + G TPLH+AA G + ++ LL+ AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLNDLVMKNALQRVK 324
KG TP+ +A + +LL R A K+G+ L+ V N L VK
Sbjct: 534 KKGFTPLHVA--AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Score = 47.8 bits (112), Expect = 1e-05
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A S +H + +Q L++AS GH V LL +
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+AA G+ + + L+ +GA+++ + KG TP+ +A NH
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Score = 47.8 bits (112), Expect = 1e-05
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
S+ F L++A+H + + Q LL GAS G TPLH+A+ G + LLL G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 269 ASIHDRDAKGETPISIAHC 287
A I + TP+ HC
Sbjct: 263 AQIETKTKDELTPL---HC 278
Score = 47.0 bits (110), Expect = 2e-05
Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 17/135 (12%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
+++A+ H D V+ LL++ A + TPLHVAA G +LL GA + R
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHR-------IAKSGIRDLNDL-------VMKNALQ 321
G TP+ IA NH R M LL + + +SG+ L+ ++KN LQ
Sbjct: 369 LNGFTPLHIACKKNHV---RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 322 RVKSGFRSEKMTMTP 336
R S S TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 46.6 bits (109), Expect = 3e-05
Identities = 24/78 (30%), Positives = 48/78 (61%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+++ AL++A+ G + V+ L+ +GA+ ++S G TPL++AA + + LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 268 GASIHDRDAKGETPISIA 285
GA+ + G TP+++A
Sbjct: 134 GANQNVATEDGFTPLAVA 151
Score = 46.6 bits (109), Expect = 3e-05
Identities = 30/90 (33%), Positives = 41/90 (45%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G + LLE A + G TPLHVA D + LLL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMV 298
S H G TP+ IA N R ++
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Score = 45.1 bits (105), Expect = 9e-05
Identities = 22/60 (36%), Positives = 35/60 (58%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ+ F LY+A+ H + V++LLE+GA+ + G TPL VA G + + L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 45.1 bits (105), Expect = 9e-05
Identities = 23/79 (29%), Positives = 43/79 (54%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H + + L++A+ + + + LL++G S + S G TPLH+AA G ++ + LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 266 QHGASIHDRDAKGETPISI 284
A+ + + G TP+ +
Sbjct: 656 SKQANGNLGNKSGLTPLHL 674
Score = 38.9 bits (89), Expect = 0.007
Identities = 40/160 (25%), Positives = 62/160 (38%), Gaps = 38/160 (23%)
Query: 191 YRTANSEHFEGEKW-------KHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSP 243
Y A H E K+ ++ ++ F L VA +GH + V +L+ +G R P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 244 L-----------------------------GRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
G TPLH+AA + LLL GAS++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 275 DAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDL 314
G TP+ IA + + R +LL R A+ + ++L
Sbjct: 236 PQNGITPLHIASRRGNVIMVR--LLLDRGAQIETKTKDEL 273
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 68.6 bits (166), Expect = 8e-12
Identities = 33/83 (39%), Positives = 55/83 (66%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ + L+VASH G+ V++LL+H A +++ LG +PLH AA G +D + LLL++
Sbjct: 697 TTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN 756
Query: 268 GASIHDRDAKGETPISIAHCLNH 290
GAS ++ + G TP++IA L +
Sbjct: 757 GASPNEVSSDGTTPLAIAKRLGY 779
Score = 61.6 bits (148), Expect = 9e-10
Identities = 37/98 (37%), Positives = 56/98 (57%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + LL+HGA +++ G +P+H+AA DC+ LLLQ+ A I D
Sbjct: 276 LHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDIT 335
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
TP+ + AHC +H +++ VLL + AK R LN
Sbjct: 336 LDHLTPLHVAAHCGHHRVAK---VLLDKGAKPNSRALN 370
Score = 55.8 bits (133), Expect = 5e-08
Identities = 38/111 (34%), Positives = 56/111 (50%), Gaps = 2/111 (1%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + H ++ LL+ GAS + + G TPLHVA+ MG + LLQ GAS +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNALQRV 323
+ K ETP+ +A HT E LL AK + +D + R+
Sbjct: 432 VSNVKVETPLHMAARAGHT--EVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/75 (40%), Positives = 41/75 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA+H GH + LL+ GA SR+ G TPLH+A + LLL+ GASI
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 276 AKGETPISIAHCLNH 290
G TP+ +A + H
Sbjct: 402 ESGLTPLHVASFMGH 416
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/80 (36%), Positives = 43/80 (53%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
++T Q L++AS RG+ V+ LL+ GA +++ TPLH AA G +LL
Sbjct: 233 NFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILL 292
Query: 266 QHGASIHDRDAKGETPISIA 285
HGA I + G +PI +A
Sbjct: 293 DHGAPIQAKTKNGLSPIHMA 312
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/89 (32%), Positives = 51/89 (57%), Gaps = 2/89 (2%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH + +YLL++ A +++ +TPLH AA +G ++ + LLL++ A+ +
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLAT 500
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA 304
G TP+ IA H E + LL + A
Sbjct: 501 TAGHTPLHIAAREGHV--ETVLALLEKEA 527
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/103 (34%), Positives = 53/103 (51%), Gaps = 8/103 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA H + D V+ LL G S S + G TPLH+AA + + LLQ+G S +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAES 632
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLN 312
+G TP+ +A H +E +LL + A KSG+ L+
Sbjct: 633 VQGVTPLHLAAQEGH--AEMVALLLSKQANGNLGNKSGLTPLH 673
Score = 50.1 bits (118), Expect = 3e-06
Identities = 28/83 (33%), Positives = 44/83 (53%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ L+VAS GH V+ LL+ GAS + TPLH+AA G ++ LLQ+
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 269 ASIHDRDAKGETPISIAHCLNHT 291
A ++ + +TP+ A + HT
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHT 483
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 18/103 (17%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++ + GH L++HG + + +G TPLHVA+ G + LLQH A ++ +
Sbjct: 672 LHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKN 318
G +P LH+ A+ G D+ L++KN
Sbjct: 732 KLGYSP------------------LHQAAQQGHTDIVTLLLKN 756
Score = 48.1 bits (113), Expect = 1e-05
Identities = 38/115 (33%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + V+ LLE+ A+ + G TPLH+AA G + ++ LL+ AS
Sbjct: 474 LHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT 533
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLNDLVMKNALQRVK 324
KG TP+ +A + +LL R A K+G+ L+ V N L VK
Sbjct: 534 KKGFTPLHVA--AKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Score = 47.8 bits (112), Expect = 1e-05
Identities = 32/109 (29%), Positives = 51/109 (46%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A S +H + +Q L++AS GH V LL +
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+AA G+ + + L+ +GA+++ + KG TP+ +A NH
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENH 123
Score = 47.8 bits (112), Expect = 1e-05
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 3/79 (3%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
S+ F L++A+H + + Q LL GAS G TPLH+A+ G + LLL G
Sbjct: 203 SKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 269 ASIHDRDAKGETPISIAHC 287
A I + TP+ HC
Sbjct: 263 AQIETKTKDELTPL---HC 278
Score = 47.0 bits (110), Expect = 2e-05
Identities = 43/135 (31%), Positives = 61/135 (45%), Gaps = 17/135 (12%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
+++A+ H D V+ LL++ A + TPLHVAA G +LL GA + R
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHR-------IAKSGIRDLNDL-------VMKNALQ 321
G TP+ IA NH R M LL + + +SG+ L+ ++KN LQ
Sbjct: 369 LNGFTPLHIACKKNHV---RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ 425
Query: 322 RVKSGFRSEKMTMTP 336
R S S TP
Sbjct: 426 RGASPNVSNVKVETP 440
Score = 46.6 bits (109), Expect = 3e-05
Identities = 24/78 (30%), Positives = 48/78 (61%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+++ AL++A+ G + V+ L+ +GA+ ++S G TPL++AA + + LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 268 GASIHDRDAKGETPISIA 285
GA+ + G TP+++A
Sbjct: 134 GANQNVATEDGFTPLAVA 151
Score = 46.6 bits (109), Expect = 3e-05
Identities = 30/90 (33%), Positives = 41/90 (45%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G + LLE A + G TPLHVA D + LLL G
Sbjct: 533 TKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRG 592
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMV 298
S H G TP+ IA N R ++
Sbjct: 593 GSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Score = 45.1 bits (105), Expect = 9e-05
Identities = 22/60 (36%), Positives = 35/60 (58%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ+ F LY+A+ H + V++LLE+GA+ + G TPL VA G + + L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 45.1 bits (105), Expect = 9e-05
Identities = 23/79 (29%), Positives = 43/79 (54%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H + + L++A+ + + + LL++G S + S G TPLH+AA G ++ + LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 266 QHGASIHDRDAKGETPISI 284
A+ + + G TP+ +
Sbjct: 656 SKQANGNLGNKSGLTPLHL 674
Score = 38.9 bits (89), Expect = 0.007
Identities = 40/160 (25%), Positives = 62/160 (38%), Gaps = 38/160 (23%)
Query: 191 YRTANSEHFEGEKW-------KHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSP 243
Y A H E K+ ++ ++ F L VA +GH + V +L+ +G R P
Sbjct: 116 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLP 175
Query: 244 L-----------------------------GRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
G TPLH+AA + LLL GAS++
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 275 DAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDL 314
G TP+ IA + + R +LL R A+ + ++L
Sbjct: 236 PQNGITPLHIASRRGNVIMVR--LLLDRGAQIETKTKDEL 273
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 62.0 bits (149), Expect = 7e-10
Identities = 34/83 (40%), Positives = 43/83 (51%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L +A GH D V LLE G++ + GRT LH A G DC+ LL H A + RD
Sbjct: 692 LMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRD 751
Query: 276 AKGETPISIAHCLNHTLSERQMV 298
KG TPI +A HT R ++
Sbjct: 752 FKGRTPIHLASACGHTAVLRTLL 774
Score = 55.5 bits (132), Expect = 7e-08
Identities = 27/70 (38%), Positives = 39/70 (55%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ G+ + + LL GA R GRTPLH AAA G C + L+ GA +++ D
Sbjct: 427 LHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEAD 486
Query: 276 AKGETPISIA 285
KG +P+ A
Sbjct: 487 CKGCSPLHYA 496
Score = 48.9 bits (115), Expect = 6e-06
Identities = 24/76 (31%), Positives = 42/76 (55%)
Query: 210 QRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGA 269
++ + L+ A+ G + V+YLL GA + G T LH+A +G+ I L+ GA
Sbjct: 204 RKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGA 263
Query: 270 SIHDRDAKGETPISIA 285
+++ + KG TP+ +A
Sbjct: 264 NVNQPNDKGFTPLHVA 279
Score = 48.5 bits (114), Expect = 8e-06
Identities = 34/102 (33%), Positives = 55/102 (53%), Gaps = 8/102 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A++ GH +A++ L E + R GRT L +A G ++C+ +L HGAS ++
Sbjct: 589 LHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKE 648
Query: 276 AKGE-TPISIAHCLNHTLSERQMVLLHRIAKSGIR-DLNDLV 315
K + TP+ A HT S LH + SG R D+ D++
Sbjct: 649 RKRKWTPLHAAAASGHTDS------LHLLIDSGERADITDVM 684
Score = 47.0 bits (110), Expect = 2e-05
Identities = 26/70 (37%), Positives = 39/70 (55%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A++ G +Q LL GA+ ++ L TPLH AAA + LLL H A ++ RD
Sbjct: 45 LHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARD 104
Query: 276 AKGETPISIA 285
+TP+ +A
Sbjct: 105 KLWQTPLHVA 114
Score = 45.8 bits (107), Expect = 5e-05
Identities = 26/64 (40%), Positives = 34/64 (53%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+ A H GH + V LL GAS R PLH AA +G + + LL+ GA + +
Sbjct: 143 ALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCK 202
Query: 275 DAKG 278
D KG
Sbjct: 203 DRKG 206
Score = 44.3 bits (103), Expect = 2e-04
Identities = 29/86 (33%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 209 SQRAFVALYVA--SHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ 266
+ + F L+VA S G ++ L+ +GA +S G++PLH+AA GR +L+Q
Sbjct: 269 NDKGFTPLHVAAVSTNGAL-CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQ 327
Query: 267 HGASIHDRDAKGETPISIAHCLNHTL 292
+G+ I D G TP+ +A H L
Sbjct: 328 NGSEIDCADKFGNTPLHVAARYGHEL 353
Score = 44.3 bits (103), Expect = 2e-04
Identities = 23/57 (40%), Positives = 32/57 (56%)
Query: 229 QYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
+++L G + LGRT LH AA+ G +C+ LLL GA + RD G TP+ A
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Score = 44.3 bits (103), Expect = 2e-04
Identities = 36/133 (27%), Positives = 60/133 (45%), Gaps = 19/133 (14%)
Query: 154 IISLCIWHHDGWTELVLAAVEGDPSKLSCLGLTEDSFYRTAN-SEHFEGEKWKHWTSQRA 212
+++L + H G T L LA G + L TA+ + E+ + WT
Sbjct: 608 LVNLDVRDHKGRTALFLATERGSTECVEVL---------TAHGASALIKERKRKWTP--- 655
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPL---GRTPLHVAAAMGRSDCIILLLQHGA 269
L+ A+ GH D++ L++ G + G+TPL +A G DC+ LLL+ G+
Sbjct: 656 ---LHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
Query: 270 SIHDRDAKGETPI 282
+ D +G T +
Sbjct: 713 TADAADLRGRTAL 725
Score = 42.7 bits (99), Expect = 5e-04
Identities = 34/90 (37%), Positives = 48/90 (53%), Gaps = 6/90 (6%)
Query: 216 LYVASHRGHFDAVQYLLEHGA-SCLSRSPLGRTPLHVAAAMGRSDCIILLLQH-GASI-H 272
++ AS+ GH D ++ LLEH S L +P TPLH A + +LL GA I +
Sbjct: 795 MHWASYTGHEDCLELLLEHSPFSYLEGNPF--TPLHCAVINNQDSTTEMLLGALGAKIVN 852
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLLHR 302
RDAKG TP+ A +S +M+L H+
Sbjct: 853 SRDAKGRTPLHAA-AFADNVSGLRMLLQHQ 881
Score = 41.6 bits (96), Expect = 0.001
Identities = 24/70 (34%), Positives = 38/70 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH + ++ L+ GA + G LH AAA G+ + + LL+ GA I + +
Sbjct: 177 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPN 236
Query: 276 AKGETPISIA 285
A G T + IA
Sbjct: 237 AFGNTALHIA 246
Score = 41.2 bits (95), Expect = 0.001
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 6/98 (6%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
++ S+ L++A+ G F Q L+++G+ G TPLHVAA G I L+
Sbjct: 300 NYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLM 359
Query: 266 QHGASIHDRDAKGETPISIA------HCLNHTLSERQM 297
+GA R P+ +A C LS Q+
Sbjct: 360 TNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQL 397
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 4/84 (4%)
Query: 211 RAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGAS 270
R AL+ + G D + LL+H A L R GRTP+H+A+A G + + LLQ S
Sbjct: 720 RGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALS 779
Query: 271 IHDRDA----KGETPISIAHCLNH 290
DA G +P+ A H
Sbjct: 780 TDPLDAGVDYSGYSPMHWASYTGH 803
Score = 39.7 bits (91), Expect = 0.004
Identities = 23/72 (31%), Positives = 42/72 (58%), Gaps = 1/72 (1%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAA-AMGRSDCIILLLQHGASIHD 273
AL++A + G L+ GA+ + G TPLHVAA + + C+ LL+ +GA ++
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 274 RDAKGETPISIA 285
+ +G++P+ +A
Sbjct: 302 QSKEGKSPLHMA 313
Score = 37.4 bits (85), Expect = 0.019
Identities = 29/90 (32%), Positives = 42/90 (46%), Gaps = 12/90 (13%)
Query: 215 ALYVASHRGHFDAVQYLLEH----GASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGAS 270
AL++A +GH +L G + S L + PLH+AA G + + LL HGA+
Sbjct: 928 ALHLACSKGHEKCALMILAETQDLGLINATNSAL-QMPLHIAARNGLASVVQALLSHGAT 986
Query: 271 IHDRDAKGETPI-------SIAHCLNHTLS 293
+ D +G TP +A CL LS
Sbjct: 987 VLAVDEEGHTPALACAPNKDVADCLALILS 1016
Score = 37.0 bits (84), Expect = 0.025
Identities = 22/78 (28%), Positives = 42/78 (53%), Gaps = 2/78 (2%)
Query: 210 QRAFVALYVASHRGHFDAVQYLLEHGASCLS--RSPLGRTPLHVAAAMGRSDCIILLLQH 267
++ + A++ A+ G+ ++ LLE +CL S + +PLH+AA G + + L +
Sbjct: 548 RQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAET 607
Query: 268 GASIHDRDAKGETPISIA 285
++ RD KG T + +A
Sbjct: 608 LVNLDVRDHKGRTALFLA 625
Score = 35.4 bits (80), Expect = 0.073
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 3/92 (3%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTP-LHVAAAMGRSDCIILLLQ 266
T+ + L++A+ G VQ LL HGA+ L+ G TP L A +DC+ L+L
Sbjct: 957 TNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALILS 1016
Query: 267 HGASIHDRDAKGETPISIAHCLNHTLSERQMV 298
+DA +P S + N +++ + V
Sbjct: 1017 TMKPFPPKDA--VSPFSFSLLKNCSIAAAKTV 1046
Score = 35.0 bits (79), Expect = 0.095
Identities = 25/80 (31%), Positives = 40/80 (50%), Gaps = 2/80 (2%)
Query: 231 LLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
LL H A +R L +TPLHVAAA + C L +S++ D G + ++ H ++
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRS--ALHHAVHS 150
Query: 291 TLSERQMVLLHRIAKSGIRD 310
E +LL++ A + D
Sbjct: 151 GHLETVNLLLNKGASLNVCD 170
Score = 33.9 bits (76), Expect = 0.21
Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 2/66 (3%)
Query: 245 GRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIA 304
GR+ LH A G + + LLL GAS++ D K P+ A L H E +L+ R A
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHL--EVLKLLVARGA 197
Query: 305 KSGIRD 310
G +D
Sbjct: 198 DLGCKD 203
Score = 33.1 bits (74), Expect = 0.36
Identities = 16/37 (43%), Positives = 23/37 (62%)
Query: 246 RTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPI 282
RTPLH AA +G + LLL GA+++ +D TP+
Sbjct: 42 RTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPL 78
Score = 32.3 bits (72), Expect = 0.62
Identities = 20/62 (32%), Positives = 32/62 (51%), Gaps = 1/62 (1%)
Query: 225 FDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISI 284
F +++LL++GA R G T +H AAA G + LLL+ + + D + P+S
Sbjct: 530 FFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLE-DVESTIPVSP 588
Query: 285 AH 286
H
Sbjct: 589 LH 590
Score = 32.0 bits (71), Expect = 0.81
Identities = 31/126 (24%), Positives = 51/126 (40%), Gaps = 7/126 (5%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG-ASIHDR 274
L+ A+ + ++ LL+H A + GRT L AA G++ + LL G A +
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVL 921
Query: 275 DAKGETPISIA------HCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNALQRVKSGFR 328
D T + +A C L+E Q + L S ++ + +N L V
Sbjct: 922 DENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981
Query: 329 SEKMTM 334
S T+
Sbjct: 982 SHGATV 987
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 60.8 bits (146), Expect = 2e-09
Identities = 39/115 (33%), Positives = 60/115 (52%), Gaps = 10/115 (8%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
+ L++++ GH D +LL+HGAS + G TPLHVAA G+ + LLLQ AS
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS-- 590
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLL-------HRIAKSGIRDLNDLVMKNAL 320
DA G++ ++ H H +++ +LL H AK+G L+ KN +
Sbjct: 591 -PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644
Score = 59.3 bits (142), Expect = 5e-09
Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 15/122 (12%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+VA+H GH+ + LL+ A+ +++ G TPLH+A R + LLL+HGASI
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAV 429
Query: 275 DAKGETPISIAHCLNH---------------TLSERQMVLLHRIAKSGIRDLNDLVMKNA 319
G TPI +A + H T + R LH A+SG ++ ++++
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG 489
Query: 320 LQ 321
Q
Sbjct: 490 AQ 491
Score = 58.9 bits (141), Expect = 6e-09
Identities = 43/144 (29%), Positives = 74/144 (51%), Gaps = 19/144 (13%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+ R AL++A+ G + V+YL++ GA +++ +TPLH++A +G++D + LLQ
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Query: 268 GASIHDRDAKGETPISI----------AHCLNHTLS-----ERQMVLLHRIAKSGIRDLN 312
GAS + G TP+ + A L+H S ++ LH AK G ++
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581
Query: 313 DLVMKNALQRVKSGFRSEKMTMTP 336
+L+ LQ+ S + K +TP
Sbjct: 582 NLL----LQKSASPDAAGKSGLTP 601
Score = 56.6 bits (135), Expect = 3e-08
Identities = 27/73 (36%), Positives = 44/73 (60%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + ++ LL+HGAS + + G TP+HVAA MG + + L+ HGAS +
Sbjct: 401 FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPN 460
Query: 273 DRDAKGETPISIA 285
+ +GET + +A
Sbjct: 461 TTNVRGETALHMA 473
Score = 54.7 bits (130), Expect = 1e-07
Identities = 28/82 (34%), Positives = 45/82 (54%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ + L+V H G+ V +LL+H A +++ G TPLH AA G + I +LLQ+
Sbjct: 727 TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNN 786
Query: 269 ASIHDRDAKGETPISIAHCLNH 290
AS ++ G T + IA L +
Sbjct: 787 ASPNELTVNGNTALGIARRLGY 808
Score = 53.1 bits (126), Expect = 3e-07
Identities = 26/82 (31%), Positives = 49/82 (59%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+Q AL++AS GH + V LL+ A+ + + G T LH+A+ G+++ + +L+ +G
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
Query: 269 ASIHDRDAKGETPISIAHCLNH 290
A+++ + G TP+ +A NH
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENH 152
Score = 52.4 bits (124), Expect = 6e-07
Identities = 30/78 (38%), Positives = 40/78 (51%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+++ F L+VA+ G + LL+ AS + G TPLHVAA +LLL
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQ 620
Query: 268 GASIHDRDAKGETPISIA 285
GAS H G TP+ IA
Sbjct: 621 GASPHAAAKNGYTPLHIA 638
Score = 51.2 bits (121), Expect = 1e-06
Identities = 31/97 (31%), Positives = 53/97 (54%), Gaps = 1/97 (1%)
Query: 207 WTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ 266
+T++ L+VAS RG+ + V+ LL+ GA +++ G TPLH A G + +LL
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD 322
Query: 267 HGASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRI 303
A I + G +P+ +A +H L+ Q++L H +
Sbjct: 323 RAAPILSKTKNGLSPLHMATQGDH-LNCVQLLLQHNV 358
Score = 51.2 bits (121), Expect = 1e-06
Identities = 24/77 (31%), Positives = 44/77 (57%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ ++VA+ GH + V L+ HGAS + + G T LH+AA G+++ + L+Q G
Sbjct: 430 TESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDG 489
Query: 269 ASIHDRDAKGETPISIA 285
A + + +TP+ I+
Sbjct: 490 AQVEAKAKDDQTPLHIS 506
Score = 49.7 bits (117), Expect = 4e-06
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ + GH V+ LL+ A LS++ G +PLH+A +C+ LLLQH + D
Sbjct: 305 LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVT 364
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
T + + AHC ++ +++ VLL + A + LN
Sbjct: 365 NDYLTALHVAAHCGHYKVAK---VLLDKKANPNAKALN 399
Score = 47.4 bits (111), Expect = 2e-05
Identities = 27/78 (34%), Positives = 40/78 (51%), Gaps = 7/78 (8%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ F LY+A+ H + V++LL++GAS + G TPL VA G + LLL++
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLEN- 195
Query: 269 ASIHDRDAKGETPISIAH 286
D KG+ + H
Sbjct: 196 ------DTKGKVRLPALH 207
Score = 46.6 bits (109), Expect = 3e-05
Identities = 40/139 (28%), Positives = 69/139 (49%), Gaps = 18/139 (12%)
Query: 148 DVVPGGI-ISLCIWHHDGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKH 206
D + G+ I++C + +G L LA+ EG +S L R AN +
Sbjct: 59 DYIKNGVDINIC--NQNGLNALHLASKEGHVEVVSEL------LQREANVDA-------- 102
Query: 207 WTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ 266
+++ AL++AS G + V+ L+ +GA+ ++S G TPL++AA + + LL
Sbjct: 103 -ATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161
Query: 267 HGASIHDRDAKGETPISIA 285
+GAS G TP+++A
Sbjct: 162 NGASQSLATEDGFTPLAVA 180
Score = 46.2 bits (108), Expect = 4e-05
Identities = 23/84 (27%), Positives = 41/84 (48%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
+++ L++A+ + + L+ GA +++ +G TPLHV G + LLQH
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752
Query: 268 GASIHDRDAKGETPISIAHCLNHT 291
A ++ + G TP+ A HT
Sbjct: 753 SAKVNAKTKNGYTPLHQAAQQGHT 776
Score = 45.4 bits (106), Expect = 7e-05
Identities = 23/80 (28%), Positives = 42/80 (52%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H ++ + L++A+ + D LLE+GA + + G +H+AA G D + LLL
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Query: 266 QHGASIHDRDAKGETPISIA 285
A+++ + G TP+ +A
Sbjct: 685 GRNANVNLSNKSGLTPLHLA 704
Score = 43.5 bits (101), Expect = 3e-04
Identities = 22/76 (28%), Positives = 40/76 (52%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ ++++A+ GH D V LL A+ + G TPLH+AA R + +L+ G
Sbjct: 661 TRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG 720
Query: 269 ASIHDRDAKGETPISI 284
A + + G TP+ +
Sbjct: 721 AHVDAQTKMGYTPLHV 736
Score = 41.2 bits (95), Expect = 0.001
Identities = 32/103 (31%), Positives = 50/103 (48%), Gaps = 8/103 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VA+H + LL+ GAS + + G TPLH+AA + D LL++GA +
Sbjct: 602 LHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVT 661
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIA------KSGIRDLN 312
+G + +A H + +LL R A KSG+ L+
Sbjct: 662 RQGIASVHLAAQEGHV--DMVSLLLGRNANVNLSNKSGLTPLH 702
Score = 38.1 bits (87), Expect = 0.011
Identities = 26/86 (30%), Positives = 42/86 (48%), Gaps = 1/86 (1%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ H + VQ LL+H + T LHVAA G +LL A+ + +
Sbjct: 338 LHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397
Query: 276 AKGETPISIAHCLNHTLSERQMVLLH 301
G TP+ IA C + + +++L H
Sbjct: 398 LNGFTPLHIA-CKKNRIKVMELLLKH 422
Score = 37.7 bits (86), Expect = 0.015
Identities = 22/71 (30%), Positives = 35/71 (49%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL++A+ + A LL++ + S G TPLH+AA G + LLL A++
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 275 DAKGETPISIA 285
TP+ +A
Sbjct: 265 ARNDITPLHVA 275
Score = 31.6 bits (70), Expect = 1.1
Identities = 25/98 (25%), Positives = 41/98 (41%), Gaps = 7/98 (7%)
Query: 195 NSEHFEGEKWKHWTSQR-------AFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRT 247
N+E +K KH R A + A+ GH + +++G + G
Sbjct: 17 NAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLN 76
Query: 248 PLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
LH+A+ G + + LLQ A++ KG T + IA
Sbjct: 77 ALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIA 114
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 60.5 bits (145), Expect = 2e-09
Identities = 43/126 (34%), Positives = 59/126 (46%), Gaps = 17/126 (13%)
Query: 161 HHD--GWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYV 218
H D GWT L +AA EG +L C L E A + + + + +
Sbjct: 842 HRDDAGWTPLHMAAFEGH--RLICEALIEQG----ARTNEIDND---------GRIPFIL 886
Query: 219 ASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKG 278
AS GH+D VQ LLE+ ++ R GR L VAA G D + LL HGA ++ +DA G
Sbjct: 887 ASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADG 946
Query: 279 ETPISI 284
+ I
Sbjct: 947 RPTLYI 952
Score = 55.8 bits (133), Expect = 5e-08
Identities = 45/125 (36%), Positives = 61/125 (48%), Gaps = 14/125 (11%)
Query: 163 DGWTELVLAAVEGDPSK--LSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVAS 220
DG T L +AA+ SK S + L D R A +H + + L VA+
Sbjct: 709 DGRTALSVAALCVPASKGHASVVSLLID---RGAEVDHCDKD---------GMTPLLVAA 756
Query: 221 HRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGET 280
+ GH D V LLE GA GRTPL AA+MG + + LL GA++ D++G T
Sbjct: 757 YEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRT 816
Query: 281 PISIA 285
+SIA
Sbjct: 817 VLSIA 821
Score = 55.5 bits (132), Expect = 7e-08
Identities = 41/123 (33%), Positives = 54/123 (43%), Gaps = 15/123 (12%)
Query: 163 DGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHR 222
DGWT L AA G +S L Y + + + + AL A+
Sbjct: 610 DGWTALRSAAWGGHTEVVSAL------LYAGVKVDCADAD---------SRTALRAAAWG 654
Query: 223 GHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPI 282
GH D V LL+HGA GRT L AA MG + + LL HGA ++ D G T +
Sbjct: 655 GHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL 714
Query: 283 SIA 285
S+A
Sbjct: 715 SVA 717
Score = 52.8 bits (125), Expect = 4e-07
Identities = 29/63 (46%), Positives = 35/63 (55%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T + AL +A+ GH D VQ LLEHGA GRT + VAA G S I LL ++
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Query: 268 GAS 270
GAS
Sbjct: 1101 GAS 1103
Score = 52.4 bits (124), Expect = 6e-07
Identities = 40/127 (31%), Positives = 54/127 (42%), Gaps = 15/127 (11%)
Query: 164 GWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRG 223
G T L LAA +G ++CL AN H + + W AL A+ G
Sbjct: 578 GHTPLTLAARQGHTKVVNCL------IGCGANINHTDQDGW---------TALRSAAWGG 622
Query: 224 HFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPIS 283
H + V LL G RT L AA G D ++ LLQHGA ++ D +G T +
Sbjct: 623 HTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALI 682
Query: 284 IAHCLNH 290
A + H
Sbjct: 683 AAAYMGH 689
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/76 (38%), Positives = 38/76 (50%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL V + +GH V L++ GA G TPL VAA G D + LLL+ GA +
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777
Query: 275 DAKGETPISIAHCLNH 290
D G TP+ A + H
Sbjct: 778 DNNGRTPLLAAASMGH 793
Score = 49.7 bits (117), Expect = 4e-06
Identities = 29/81 (35%), Positives = 42/81 (51%), Gaps = 5/81 (6%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVA-----AAMGRSDCIILLLQHGA 269
AL A++ GH + V++LL+HGA GRT L VA A+ G + + LL+ GA
Sbjct: 680 ALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGA 739
Query: 270 SIHDRDAKGETPISIAHCLNH 290
+ D G TP+ +A H
Sbjct: 740 EVDHCDKDGMTPLLVAAYEGH 760
Score = 49.7 bits (117), Expect = 4e-06
Identities = 35/98 (35%), Positives = 49/98 (50%), Gaps = 6/98 (6%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL A+ +GH VQ L+EHGA G T L +AA G D + +LL+HGA +
Sbjct: 1015 ALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHA 1074
Query: 275 DAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLN 312
D G T + +A H+ Q++ L + K G LN
Sbjct: 1075 DQFGRTAMRVAAKNGHS----QIIKL--LEKYGASSLN 1106
Score = 48.5 bits (114), Expect = 8e-06
Identities = 40/130 (30%), Positives = 52/130 (40%), Gaps = 15/130 (11%)
Query: 163 DGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHR 222
DG T L++AA EG + L EG T L A+
Sbjct: 747 DGMTPLLVAAYEGHVDVVDLL---------------LEGGADVDHTDNNGRTPLLAAASM 791
Query: 223 GHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPI 282
GH V LL GA+ S GRT L +A+A G + + LL G + RD G TP+
Sbjct: 792 GHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851
Query: 283 SIAHCLNHTL 292
+A H L
Sbjct: 852 HMAAFEGHRL 861
Score = 46.2 bits (108), Expect = 4e-05
Identities = 26/66 (39%), Positives = 37/66 (56%)
Query: 226 DAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
D+++ LL++GAS GRT L AA G D + LL+ GA + DA G TP+++A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 286 HCLNHT 291
HT
Sbjct: 586 ARQGHT 591
Score = 41.6 bits (96), Expect = 0.001
Identities = 25/75 (33%), Positives = 37/75 (49%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L +AS +G+ + V+ LL+ G R G TPLH+AA G L++ GA ++ D
Sbjct: 818 LSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEID 877
Query: 276 AKGETPISIAHCLNH 290
G P +A H
Sbjct: 878 NDGRIPFILASQEGH 892
Score = 39.7 bits (91), Expect = 0.004
Identities = 24/73 (32%), Positives = 34/73 (46%)
Query: 219 ASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKG 278
A++ G D V L+ GA G TPL +AA G + + L+ GA+I+ D G
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDG 611
Query: 279 ETPISIAHCLNHT 291
T + A HT
Sbjct: 612 WTALRSAAWGGHT 624
Score = 37.7 bits (86), Expect = 0.015
Identities = 19/75 (25%), Positives = 36/75 (48%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
LY+ + +Y LE+GA+ + GRT LHV+ G + + +L+ + A ++ D
Sbjct: 950 LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
Query: 276 AKGETPISIAHCLNH 290
+ + + A H
Sbjct: 1010 NEKRSALQSAAWQGH 1024
Score = 31.6 bits (70), Expect = 1.1
Identities = 21/60 (35%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 226 DAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
+ +Q L++ GA S RT V A+ R D I LL +GAS++ D+ G T ++ A
Sbjct: 495 EVLQLLVKAGAHVNSEDD--RTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552
>gi|169403959 ankyrin repeat domain 53 isoform a [Homo sapiens]
Length = 530
Score = 59.3 bits (142), Expect = 5e-09
Identities = 32/84 (38%), Positives = 46/84 (54%), Gaps = 4/84 (4%)
Query: 216 LYVASHRGH----FDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASI 271
L++ HR + + YLLE GA +++ G TPLH+AA G DC+ +L+Q GA++
Sbjct: 178 LHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANV 237
Query: 272 HDRDAKGETPISIAHCLNHTLSER 295
H +DA G PI NH R
Sbjct: 238 HAQDAMGYKPIDFCKIWNHRACAR 261
>gi|169403957 ankyrin repeat domain 53 isoform b [Homo sapiens]
Length = 343
Score = 59.3 bits (142), Expect = 5e-09
Identities = 32/84 (38%), Positives = 46/84 (54%), Gaps = 4/84 (4%)
Query: 216 LYVASHRGH----FDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASI 271
L++ HR + + YLLE GA +++ G TPLH+AA G DC+ +L+Q GA++
Sbjct: 178 LHLVIHRDNTTVALPCIYYLLEKGADLNAQTCNGSTPLHLAARDGLLDCVKVLVQSGANV 237
Query: 272 HDRDAKGETPISIAHCLNHTLSER 295
H +DA G PI NH R
Sbjct: 238 HAQDAMGYKPIDFCKIWNHRACAR 261
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 58.9 bits (141), Expect = 6e-09
Identities = 29/68 (42%), Positives = 38/68 (55%)
Query: 223 GHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPI 282
GH D V LL GA+ ++ GRT LH A G +C+ LLQHGA RD++G TPI
Sbjct: 664 GHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 723
Query: 283 SIAHCLNH 290
++ H
Sbjct: 724 HLSAACGH 731
Score = 55.5 bits (132), Expect = 7e-08
Identities = 34/95 (35%), Positives = 49/95 (51%), Gaps = 1/95 (1%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ G+ + + LL GA + GR+PLH AAA C+ L+ GAS++D D
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRD 310
+G TP+ A + T + LL A GIRD
Sbjct: 469 ERGCTPLHYA-ATSDTDGKCLEYLLRNDANPGIRD 502
Score = 52.8 bits (125), Expect = 4e-07
Identities = 26/75 (34%), Positives = 42/75 (56%), Gaps = 1/75 (1%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
A++ A++ GH + V+ L+ HGA + TPLH AA+ G + LL G +++
Sbjct: 176 AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEP 235
Query: 275 DAKGETPISIAHCLN 289
+A G TP+ +A C N
Sbjct: 236 NAYGNTPLHVA-CYN 249
Score = 52.0 bits (123), Expect = 8e-07
Identities = 27/65 (41%), Positives = 37/65 (56%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+ + GH + V LL+HGA CL R GRTP+H++AA G + LLQ AS+
Sbjct: 689 ALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDAN 748
Query: 275 DAKGE 279
A +
Sbjct: 749 PATAD 753
Score = 49.7 bits (117), Expect = 4e-06
Identities = 25/81 (30%), Positives = 42/81 (51%)
Query: 210 QRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGA 269
++++ L+ A+ G V+YLL+ G + G TPLHVA G+ + L+ GA
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 270 SIHDRDAKGETPISIAHCLNH 290
++ ++ KG TP+ A H
Sbjct: 264 IVNQKNEKGFTPLHFAAASTH 284
Score = 47.8 bits (112), Expect = 1e-05
Identities = 26/71 (36%), Positives = 39/71 (54%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+ A+ GH + V+ LL GA+ + R +H AA MG + + LL+ HGA + +
Sbjct: 143 ALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCK 202
Query: 275 DAKGETPISIA 285
D K TP+ A
Sbjct: 203 DKKSYTPLHAA 213
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/80 (36%), Positives = 45/80 (56%), Gaps = 2/80 (2%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEH-GASCLSRSPL-GRTPLHVAAAMGRSDCIILLL 265
T AF L+ A + A + L++ GAS ++ + GRTPLH AA +C+ LLL
Sbjct: 784 TEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL 843
Query: 266 QHGASIHDRDAKGETPISIA 285
H A ++ D+ G+TP+ +A
Sbjct: 844 SHNAQVNSVDSTGKTPLMMA 863
Score = 46.6 bits (109), Expect = 3e-05
Identities = 26/70 (37%), Positives = 37/70 (52%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ G D + LL G + GRT LH AAA G +C+ LLL GA + +D
Sbjct: 376 LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD 435
Query: 276 AKGETPISIA 285
G +P+ A
Sbjct: 436 KFGRSPLHYA 445
Score = 46.6 bits (109), Expect = 3e-05
Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 1/84 (1%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A++ GH A++ L++ R+ GRTPL +AA G +C+ +L+ GASI +D
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKD 613
Query: 276 -AKGETPISIAHCLNHTLSERQMV 298
TPI A H+ R ++
Sbjct: 614 YILKRTPIHAAATNGHSECLRLLI 637
Score = 45.1 bits (105), Expect = 9e-05
Identities = 28/85 (32%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 209 SQRAFVALYVASHRGHFD-AVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
+++ F L+ A+ H ++ L+ +GA +S G+TPLH+ A GR ++Q
Sbjct: 269 NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS 328
Query: 268 GASIHDRDAKGETPISIAHCLNHTL 292
GA I D G TP+ IA H L
Sbjct: 329 GAVIDCEDKNGNTPLHIAARYGHEL 353
Score = 44.7 bits (104), Expect = 1e-04
Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 15/118 (12%)
Query: 168 LVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRGHFDA 227
LV A GDP ++ L ++ N + L+ A++ G +
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKR---------------TPLHAAAYLGDAEI 56
Query: 228 VQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
++ L+ GA ++ TPLH A A + + +LL+H A ++ RD +TP+ IA
Sbjct: 57 IELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIA 114
Score = 43.9 bits (102), Expect = 2e-04
Identities = 30/84 (35%), Positives = 38/84 (45%), Gaps = 6/84 (7%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH + L+ GA R G PLH+AA G SDC LL G I D
Sbjct: 343 LHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD 402
Query: 276 AKGETPISIA------HCLNHTLS 293
G T + A CLN L+
Sbjct: 403 DFGRTCLHAAAAGGNLECLNLLLN 426
Score = 40.0 bits (92), Expect = 0.003
Identities = 27/114 (23%), Positives = 53/114 (46%), Gaps = 3/114 (2%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T + L+ A+ H + +Q LL H A S G+TPL +AA G+++ + +L+
Sbjct: 819 TDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSS 878
Query: 268 -GASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVMKNAL 320
A + +D T + +A H S +++L +I + + + ++ L
Sbjct: 879 ASAELTLQDNSKNTALHLACSKGHETS--ALLILEKITDRNLINATNAALQTPL 930
Score = 38.9 bits (89), Expect = 0.007
Identities = 29/88 (32%), Positives = 41/88 (46%), Gaps = 2/88 (2%)
Query: 226 DAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
+AVQ LL+H A +R +TPLH+AAA C L+ ++++ D G T + A
Sbjct: 88 EAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHA 147
Query: 286 HCLNHTLSERQMVLLHRIAKSGIRDLND 313
H E +LL R A D D
Sbjct: 148 AFSGH--GEMVKLLLSRGANINAFDKKD 173
Score = 38.5 bits (88), Expect = 0.009
Identities = 22/70 (31%), Positives = 32/70 (45%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++ + G F Q +++ GA G TPLH+AA G I L+ GA R
Sbjct: 310 LHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRG 369
Query: 276 AKGETPISIA 285
G P+ +A
Sbjct: 370 IHGMFPLHLA 379
Score = 37.7 bits (86), Expect = 0.015
Identities = 36/132 (27%), Positives = 49/132 (37%), Gaps = 39/132 (29%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSP-LGRTPLHVAAAMGRS---------------- 258
L +A+ +GH + V L+ GAS L + L RTP+H AA G S
Sbjct: 587 LDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAV 646
Query: 259 --------------------DCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMV 298
DC+ LL GA++ +D G T + H E
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGH--EECVDA 704
Query: 299 LLHRIAKSGIRD 310
LL AK +RD
Sbjct: 705 LLQHGAKCLLRD 716
Score = 33.9 bits (76), Expect = 0.21
Identities = 19/46 (41%), Positives = 24/46 (52%)
Query: 245 GRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
GRT LH AA G + + LLL GA+I+ D K I A + H
Sbjct: 140 GRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGH 185
Score = 32.7 bits (73), Expect = 0.47
Identities = 24/70 (34%), Positives = 35/70 (50%), Gaps = 3/70 (4%)
Query: 215 ALYVASHRGHFDAVQYLLEHGAS---CLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASI 271
AL++A +GH + +LE + + +TPLHVAA G + + LL GAS+
Sbjct: 893 ALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV 952
Query: 272 HDRDAKGETP 281
D G TP
Sbjct: 953 LAVDENGYTP 962
Score = 30.8 bits (68), Expect = 1.8
Identities = 19/64 (29%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Query: 247 TPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIAKS 306
+PLH+AA G + +L+Q + R++ G TP+ +A H E VL+++ A
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHV--ECVDVLINQGASI 609
Query: 307 GIRD 310
++D
Sbjct: 610 LVKD 613
>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
Length = 300
Score = 58.9 bits (141), Expect = 6e-09
Identities = 29/65 (44%), Positives = 36/65 (55%)
Query: 226 DAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
+ VQ LLE GA + GRT LH A+ G + LLL HGA + RD G TP+ +A
Sbjct: 124 ETVQQLLEDGADPCAADDKGRTALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLA 183
Query: 286 HCLNH 290
C NH
Sbjct: 184 ACTNH 188
Score = 56.6 bits (135), Expect = 3e-08
Identities = 33/80 (41%), Positives = 42/80 (52%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+ AS G+ VQ LL+HGA R LG TPLH+AA I LL+ GA +
Sbjct: 146 ALHFASCNGNDQIVQLLLDHGADPNQRDGLGNTPLHLAACTNHVPVITTLLRGGARVDAL 205
Query: 275 DAKGETPISIAHCLNHTLSE 294
D G TP+ +A + L E
Sbjct: 206 DRAGRTPLHLAKSKLNILQE 225
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 58.2 bits (139), Expect = 1e-08
Identities = 34/104 (32%), Positives = 50/104 (48%), Gaps = 5/104 (4%)
Query: 204 WKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIIL 263
W + + + L +A +G +D V L++H S + +H AA GR D + L
Sbjct: 136 WPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVAL 195
Query: 264 LLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSG 307
LL+HG ++H RD G TP+ +A H VL H I K G
Sbjct: 196 LLKHGGNVHLRDGFGVTPLGVAAEYGHC-----DVLEHLIHKGG 234
Score = 49.7 bits (117), Expect = 4e-06
Identities = 32/100 (32%), Positives = 53/100 (53%), Gaps = 3/100 (3%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L VA+ GH D +++L+ G L+ + G + L AA G DCI LLL++G S + +
Sbjct: 214 LGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPN 273
Query: 276 AKGETPISIAHCLNHTLSERQMVLL---HRIAKSGIRDLN 312
G PI A H L+ + ++ + + I KSG+ ++
Sbjct: 274 RAGHLPIHRAAYEGHYLALKYLIPVTSKNAIRKSGLTPIH 313
Score = 35.0 bits (79), Expect = 0.095
Identities = 26/89 (29%), Positives = 42/89 (47%), Gaps = 15/89 (16%)
Query: 245 GRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA----------HCLNHTLSE 294
G TPL +A G + + LL+ G + ++ KGETP+ IA + H S
Sbjct: 111 GETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNTSL 170
Query: 295 RQMVL-----LHRIAKSGIRDLNDLVMKN 318
Q + +H AK G +D+ L++K+
Sbjct: 171 DQPCVKRWSAMHEAAKQGRKDIVALLLKH 199
Score = 33.9 bits (76), Expect = 0.21
Identities = 17/57 (29%), Positives = 34/57 (59%), Gaps = 1/57 (1%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
++ A++ GH+ A++YL+ + R G TP+H AA + C+ LL+++G ++
Sbjct: 280 IHRAAYEGHYLALKYLIPVTSKNAIRKS-GLTPIHSAADGQNAQCLELLIENGFDVN 335
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 58.2 bits (139), Expect = 1e-08
Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 5/91 (5%)
Query: 205 KHWTSQRA-----FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSD 259
KH Q A + L VA H G+ V +LL+ GA+ +++ G TPLH AA G +
Sbjct: 695 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 754
Query: 260 CIILLLQHGASIHDRDAKGETPISIAHCLNH 290
I +LLQHGA + A G T ++IA L +
Sbjct: 755 IINVLLQHGAKPNATTANGNTALAIAKRLGY 785
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/109 (32%), Positives = 59/109 (54%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A + E+ +G + +Q AL++A+ GH VQ LL G+S S
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+A+ G+++ + +L++ GA+I+ + G TP+ +A NH
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 121
Score = 55.5 bits (132), Expect = 7e-08
Identities = 32/98 (32%), Positives = 51/98 (52%), Gaps = 6/98 (6%)
Query: 207 WTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ 266
+T++ L+VAS RG+ + V+ LL+ G +++ G TPLH AA G + LLL+
Sbjct: 240 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 299
Query: 267 HGASIHDRDAKGETPISIA------HCLNHTLSERQMV 298
GA + R G +P+ +A C+ H L + V
Sbjct: 300 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 337
Score = 55.1 bits (131), Expect = 9e-08
Identities = 39/122 (31%), Positives = 60/122 (49%), Gaps = 6/122 (4%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ F L++A+H G+ + LL GA+ + G TPLHVA+ G ++ + LLL
Sbjct: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267
Query: 268 GASIHDRDAKGETPISIAHCLNH-----TLSERQMVLLHRIAKSGIRDLNDLVMKNALQR 322
G I + G TP+ A H L ER LL R K+G+ L+ + ++
Sbjct: 268 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQGDHVEC 326
Query: 323 VK 324
VK
Sbjct: 327 VK 328
Score = 55.1 bits (131), Expect = 9e-08
Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH V+ LLE GA L+R+ G +PLH+AA +C+ LLQH A + D
Sbjct: 282 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 341
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
T + + AHC ++ +++ +LL + A R LN
Sbjct: 342 LDYLTALHVAAHCGHYRVTK---LLLDKRANPNARALN 376
Score = 55.1 bits (131), Expect = 9e-08
Identities = 30/76 (39%), Positives = 45/76 (59%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+VA+H GH+ + LL+ A+ +R+ G TPLH+A R + LL+++GASI
Sbjct: 347 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
Query: 275 DAKGETPISIAHCLNH 290
G TPI +A + H
Sbjct: 407 TESGLTPIHVAAFMGH 422
Score = 55.1 bits (131), Expect = 9e-08
Identities = 27/73 (36%), Positives = 46/73 (63%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + ++ L+++GAS + + G TP+HVAA MG + ++LLLQ+GAS
Sbjct: 378 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 273 DRDAKGETPISIA 285
+ +GET + +A
Sbjct: 438 VTNIRGETALHMA 450
Score = 54.3 bits (129), Expect = 2e-07
Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 19/144 (13%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+ R AL++A+ G + V+ LL +GA +R+ +TPLH+A+ +G+++ + LLLQH
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 268 GASIHDRDAKGETPISI---------------AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
A G TP+ I A + +++ LH AK G D
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD-- 556
Query: 313 DLVMKNALQRVKSGFRSEKMTMTP 336
V K LQR + + K +TP
Sbjct: 557 --VAKLLLQRRAAADSAGKNGLTP 578
Score = 54.3 bits (129), Expect = 2e-07
Identities = 38/116 (32%), Positives = 54/116 (46%), Gaps = 10/116 (8%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
+ L++++ G D LLE GA+ + G TPLHVAA G D LLLQ A+
Sbjct: 510 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 569
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLL-------HRIAKSGIRDLNDLVMKNALQ 321
G TP+ H H +++ +LL H AK+G L+ KN +Q
Sbjct: 570 SAGKNGLTPL---HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 622
Score = 53.5 bits (127), Expect = 3e-07
Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 18/139 (12%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G D + LL+ A+ S G TPLHVAA +LLL+ G
Sbjct: 539 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 598
Query: 269 ASIHDRDAKGETPISIAHCLN---------------HTLSERQMVLLHRIAKSGIRDLND 313
AS H G TP+ IA N + ++++ + LH ++ G D+
Sbjct: 599 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 658
Query: 314 LVM---KNALQRVKSGFRS 329
L++ N KSG S
Sbjct: 659 LLLDKGANIHMSTKSGLTS 677
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 8/112 (7%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ F LY+A+ H D V+YLLE+GA+ + + G TPL VA G + + +LL++
Sbjct: 106 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 165
Query: 269 A-------SIHDRDAKGETPISIAHCLN-HTLSERQMVLLHRIAKSGIRDLN 312
++H K +T + N H + ++++R +SG L+
Sbjct: 166 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLH 217
Score = 52.4 bits (124), Expect = 6e-07
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 145 KFHDVVPGGI-ISLCIWHHDGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEK 203
K + + GGI I+ C + +G L LAA EG +GL ++ R ++ +
Sbjct: 25 KVVEYLKGGIDINTC--NQNGLNALHLAAKEGH------VGLVQELLGRGSSVDS----- 71
Query: 204 WKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIIL 263
+++ AL++AS G + V+ L++ GA+ ++S G TPL++AA D +
Sbjct: 72 ----ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
Query: 264 LLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIR 309
LL++GA+ G TP+++A H ++ +LL K +R
Sbjct: 128 LLENGANQSTATEDGFTPLAVALQQGH--NQAVAILLENDTKGKVR 171
Score = 51.2 bits (121), Expect = 1e-06
Identities = 26/80 (32%), Positives = 42/80 (52%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H T++ + L++A+ + LL +GA + G TPLH+A+ G +D + LLL
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 266 QHGASIHDRDAKGETPISIA 285
GA+IH G T + +A
Sbjct: 662 DKGANIHMSTKSGLTSLHLA 681
Score = 50.4 bits (119), Expect = 2e-06
Identities = 32/96 (33%), Positives = 53/96 (55%), Gaps = 2/96 (2%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ ++VA+ GH + V LL++GAS + G T LH+AA G+ + + LL++G
Sbjct: 407 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIA 304
A + R + +TP+ IA L T E +LL +A
Sbjct: 467 ALVDARAREEQTPLHIASRLGKT--EIVQLLLQHMA 500
Score = 46.6 bits (109), Expect = 3e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H +++ +L++A+ + L +HGA + + LG TPL VA G + LL
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727
Query: 266 QHGASIHDRDAKGETPISIAHCLNHT 291
+ GA+++ + G TP+ A HT
Sbjct: 728 KQGANVNAKTKNGYTPLHQAAQQGHT 753
Score = 45.1 bits (105), Expect = 9e-05
Identities = 25/77 (32%), Positives = 40/77 (51%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ L++AS GH D V LL+ GA+ + G T LH+AA + + +L +HG
Sbjct: 638 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 697
Query: 269 ASIHDRDAKGETPISIA 285
A G TP+ +A
Sbjct: 698 ADQDAHTKLGYTPLIVA 714
Score = 37.7 bits (86), Expect = 0.015
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ H + V++LL+H A + T LHVAA G LLL A+ + R
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374
Query: 276 AKGETPISIAHCLNHTLSERQMVL-----LHRIAKSGIRDLN 312
G TP+ IA C + + ++++ + I +SG+ ++
Sbjct: 375 LNGFTPLHIA-CKKNRIKVMELLVKYGASIQAITESGLTPIH 415
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 58.2 bits (139), Expect = 1e-08
Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 5/91 (5%)
Query: 205 KHWTSQRA-----FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSD 259
KH Q A + L VA H G+ V +LL+ GA+ +++ G TPLH AA G +
Sbjct: 716 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 775
Query: 260 CIILLLQHGASIHDRDAKGETPISIAHCLNH 290
I +LLQHGA + A G T ++IA L +
Sbjct: 776 IINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/109 (32%), Positives = 59/109 (54%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A + E+ +G + +Q AL++A+ GH VQ LL G+S S
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+A+ G+++ + +L++ GA+I+ + G TP+ +A NH
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142
Score = 55.5 bits (132), Expect = 7e-08
Identities = 32/98 (32%), Positives = 51/98 (52%), Gaps = 6/98 (6%)
Query: 207 WTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ 266
+T++ L+VAS RG+ + V+ LL+ G +++ G TPLH AA G + LLL+
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Query: 267 HGASIHDRDAKGETPISIA------HCLNHTLSERQMV 298
GA + R G +P+ +A C+ H L + V
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Score = 55.1 bits (131), Expect = 9e-08
Identities = 39/122 (31%), Positives = 60/122 (49%), Gaps = 6/122 (4%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ F L++A+H G+ + LL GA+ + G TPLHVA+ G ++ + LLL
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 268 GASIHDRDAKGETPISIAHCLNH-----TLSERQMVLLHRIAKSGIRDLNDLVMKNALQR 322
G I + G TP+ A H L ER LL R K+G+ L+ + ++
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQGDHVEC 347
Query: 323 VK 324
VK
Sbjct: 348 VK 349
Score = 55.1 bits (131), Expect = 9e-08
Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH V+ LLE GA L+R+ G +PLH+AA +C+ LLQH A + D
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
T + + AHC ++ +++ +LL + A R LN
Sbjct: 363 LDYLTALHVAAHCGHYRVTK---LLLDKRANPNARALN 397
Score = 55.1 bits (131), Expect = 9e-08
Identities = 30/76 (39%), Positives = 45/76 (59%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+VA+H GH+ + LL+ A+ +R+ G TPLH+A R + LL+++GASI
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 275 DAKGETPISIAHCLNH 290
G TPI +A + H
Sbjct: 428 TESGLTPIHVAAFMGH 443
Score = 55.1 bits (131), Expect = 9e-08
Identities = 27/73 (36%), Positives = 46/73 (63%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + ++ L+++GAS + + G TP+HVAA MG + ++LLLQ+GAS
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 273 DRDAKGETPISIA 285
+ +GET + +A
Sbjct: 459 VTNIRGETALHMA 471
Score = 54.3 bits (129), Expect = 2e-07
Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 19/144 (13%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+ R AL++A+ G + V+ LL +GA +R+ +TPLH+A+ +G+++ + LLLQH
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 268 GASIHDRDAKGETPISI---------------AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
A G TP+ I A + +++ LH AK G D
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD-- 577
Query: 313 DLVMKNALQRVKSGFRSEKMTMTP 336
V K LQR + + K +TP
Sbjct: 578 --VAKLLLQRRAAADSAGKNGLTP 599
Score = 54.3 bits (129), Expect = 2e-07
Identities = 38/116 (32%), Positives = 54/116 (46%), Gaps = 10/116 (8%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
+ L++++ G D LLE GA+ + G TPLHVAA G D LLLQ A+
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLL-------HRIAKSGIRDLNDLVMKNALQ 321
G TP+ H H +++ +LL H AK+G L+ KN +Q
Sbjct: 591 SAGKNGLTPL---HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Score = 53.5 bits (127), Expect = 3e-07
Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 18/139 (12%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G D + LL+ A+ S G TPLHVAA +LLL+ G
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
Query: 269 ASIHDRDAKGETPISIAHCLN---------------HTLSERQMVLLHRIAKSGIRDLND 313
AS H G TP+ IA N + ++++ + LH ++ G D+
Sbjct: 620 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 314 LVM---KNALQRVKSGFRS 329
L++ N KSG S
Sbjct: 680 LLLDKGANIHMSTKSGLTS 698
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 8/112 (7%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ F LY+A+ H D V+YLLE+GA+ + + G TPL VA G + + +LL++
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 186
Query: 269 A-------SIHDRDAKGETPISIAHCLN-HTLSERQMVLLHRIAKSGIRDLN 312
++H K +T + N H + ++++R +SG L+
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLH 238
Score = 52.4 bits (124), Expect = 6e-07
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 145 KFHDVVPGGI-ISLCIWHHDGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEK 203
K + + GGI I+ C + +G L LAA EG +GL ++ R ++ +
Sbjct: 46 KVVEYLKGGIDINTC--NQNGLNALHLAAKEGH------VGLVQELLGRGSSVDS----- 92
Query: 204 WKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIIL 263
+++ AL++AS G + V+ L++ GA+ ++S G TPL++AA D +
Sbjct: 93 ----ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 264 LLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIR 309
LL++GA+ G TP+++A H ++ +LL K +R
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGH--NQAVAILLENDTKGKVR 192
Score = 51.2 bits (121), Expect = 1e-06
Identities = 26/80 (32%), Positives = 42/80 (52%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H T++ + L++A+ + LL +GA + G TPLH+A+ G +D + LLL
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 266 QHGASIHDRDAKGETPISIA 285
GA+IH G T + +A
Sbjct: 683 DKGANIHMSTKSGLTSLHLA 702
Score = 50.4 bits (119), Expect = 2e-06
Identities = 32/96 (33%), Positives = 53/96 (55%), Gaps = 2/96 (2%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ ++VA+ GH + V LL++GAS + G T LH+AA G+ + + LL++G
Sbjct: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIA 304
A + R + +TP+ IA L T E +LL +A
Sbjct: 488 ALVDARAREEQTPLHIASRLGKT--EIVQLLLQHMA 521
Score = 46.6 bits (109), Expect = 3e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H +++ +L++A+ + L +HGA + + LG TPL VA G + LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 266 QHGASIHDRDAKGETPISIAHCLNHT 291
+ GA+++ + G TP+ A HT
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHT 774
Score = 45.1 bits (105), Expect = 9e-05
Identities = 25/77 (32%), Positives = 40/77 (51%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ L++AS GH D V LL+ GA+ + G T LH+AA + + +L +HG
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718
Query: 269 ASIHDRDAKGETPISIA 285
A G TP+ +A
Sbjct: 719 ADQDAHTKLGYTPLIVA 735
Score = 37.7 bits (86), Expect = 0.015
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ H + V++LL+H A + T LHVAA G LLL A+ + R
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 276 AKGETPISIAHCLNHTLSERQMVL-----LHRIAKSGIRDLN 312
G TP+ IA C + + ++++ + I +SG+ ++
Sbjct: 396 LNGFTPLHIA-CKKNRIKVMELLVKYGASIQAITESGLTPIH 436
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 58.2 bits (139), Expect = 1e-08
Identities = 35/91 (38%), Positives = 49/91 (53%), Gaps = 5/91 (5%)
Query: 205 KHWTSQRA-----FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSD 259
KH Q A + L VA H G+ V +LL+ GA+ +++ G TPLH AA G +
Sbjct: 716 KHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTH 775
Query: 260 CIILLLQHGASIHDRDAKGETPISIAHCLNH 290
I +LLQHGA + A G T ++IA L +
Sbjct: 776 IINVLLQHGAKPNATTANGNTALAIAKRLGY 806
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/109 (32%), Positives = 59/109 (54%), Gaps = 7/109 (6%)
Query: 189 SFYRTANS-------EHFEGEKWKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSR 241
SF R A + E+ +G + +Q AL++A+ GH VQ LL G+S S
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 242 SPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
+ G T LH+A+ G+++ + +L++ GA+I+ + G TP+ +A NH
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENH 142
Score = 55.5 bits (132), Expect = 7e-08
Identities = 32/98 (32%), Positives = 51/98 (52%), Gaps = 6/98 (6%)
Query: 207 WTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ 266
+T++ L+VAS RG+ + V+ LL+ G +++ G TPLH AA G + LLL+
Sbjct: 261 FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE 320
Query: 267 HGASIHDRDAKGETPISIA------HCLNHTLSERQMV 298
GA + R G +P+ +A C+ H L + V
Sbjct: 321 RGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPV 358
Score = 55.1 bits (131), Expect = 9e-08
Identities = 39/122 (31%), Positives = 60/122 (49%), Gaps = 6/122 (4%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T++ F L++A+H G+ + LL GA+ + G TPLHVA+ G ++ + LLL
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 268 GASIHDRDAKGETPISIAHCLNH-----TLSERQMVLLHRIAKSGIRDLNDLVMKNALQR 322
G I + G TP+ A H L ER LL R K+G+ L+ + ++
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQGDHVEC 347
Query: 323 VK 324
VK
Sbjct: 348 VK 349
Score = 55.1 bits (131), Expect = 9e-08
Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 4/98 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+ A+ GH V+ LLE GA L+R+ G +PLH+AA +C+ LLQH A + D
Sbjct: 303 LHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVT 362
Query: 276 AKGETPISI-AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
T + + AHC ++ +++ +LL + A R LN
Sbjct: 363 LDYLTALHVAAHCGHYRVTK---LLLDKRANPNARALN 397
Score = 55.1 bits (131), Expect = 9e-08
Identities = 30/76 (39%), Positives = 45/76 (59%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+VA+H GH+ + LL+ A+ +R+ G TPLH+A R + LL+++GASI
Sbjct: 368 ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 427
Query: 275 DAKGETPISIAHCLNH 290
G TPI +A + H
Sbjct: 428 TESGLTPIHVAAFMGH 443
Score = 55.1 bits (131), Expect = 9e-08
Identities = 27/73 (36%), Positives = 46/73 (63%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
F L++A + ++ L+++GAS + + G TP+HVAA MG + ++LLLQ+GAS
Sbjct: 399 FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 273 DRDAKGETPISIA 285
+ +GET + +A
Sbjct: 459 VTNIRGETALHMA 471
Score = 54.3 bits (129), Expect = 2e-07
Identities = 43/144 (29%), Positives = 68/144 (47%), Gaps = 19/144 (13%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+ R AL++A+ G + V+ LL +GA +R+ +TPLH+A+ +G+++ + LLLQH
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 268 GASIHDRDAKGETPISI---------------AHCLNHTLSERQMVLLHRIAKSGIRDLN 312
A G TP+ I A + +++ LH AK G D
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLD-- 577
Query: 313 DLVMKNALQRVKSGFRSEKMTMTP 336
V K LQR + + K +TP
Sbjct: 578 --VAKLLLQRRAAADSAGKNGLTP 599
Score = 54.3 bits (129), Expect = 2e-07
Identities = 38/116 (32%), Positives = 54/116 (46%), Gaps = 10/116 (8%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
+ L++++ G D LLE GA+ + G TPLHVAA G D LLLQ A+
Sbjct: 531 YTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAAD 590
Query: 273 DRDAKGETPISIAHCLNHTLSERQMVLL-------HRIAKSGIRDLNDLVMKNALQ 321
G TP+ H H +++ +LL H AK+G L+ KN +Q
Sbjct: 591 SAGKNGLTPL---HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQ 643
Score = 53.5 bits (127), Expect = 3e-07
Identities = 41/139 (29%), Positives = 63/139 (45%), Gaps = 18/139 (12%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ F L+VA+ G D + LL+ A+ S G TPLHVAA +LLL+ G
Sbjct: 560 TKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKG 619
Query: 269 ASIHDRDAKGETPISIAHCLN---------------HTLSERQMVLLHRIAKSGIRDLND 313
AS H G TP+ IA N + ++++ + LH ++ G D+
Sbjct: 620 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 314 LVM---KNALQRVKSGFRS 329
L++ N KSG S
Sbjct: 680 LLLDKGANIHMSTKSGLTS 698
Score = 53.1 bits (126), Expect = 3e-07
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 8/112 (7%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
SQ F LY+A+ H D V+YLLE+GA+ + + G TPL VA G + + +LL++
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND 186
Query: 269 A-------SIHDRDAKGETPISIAHCLN-HTLSERQMVLLHRIAKSGIRDLN 312
++H K +T + N H + ++++R +SG L+
Sbjct: 187 TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLH 238
Score = 52.4 bits (124), Expect = 6e-07
Identities = 46/166 (27%), Positives = 82/166 (49%), Gaps = 20/166 (12%)
Query: 145 KFHDVVPGGI-ISLCIWHHDGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEK 203
K + + GGI I+ C + +G L LAA EG +GL ++ R ++ +
Sbjct: 46 KVVEYLKGGIDINTC--NQNGLNALHLAAKEGH------VGLVQELLGRGSSVDS----- 92
Query: 204 WKHWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIIL 263
+++ AL++AS G + V+ L++ GA+ ++S G TPL++AA D +
Sbjct: 93 ----ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 148
Query: 264 LLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIR 309
LL++GA+ G TP+++A H ++ +LL K +R
Sbjct: 149 LLENGANQSTATEDGFTPLAVALQQGH--NQAVAILLENDTKGKVR 192
Score = 51.2 bits (121), Expect = 1e-06
Identities = 26/80 (32%), Positives = 42/80 (52%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H T++ + L++A+ + LL +GA + G TPLH+A+ G +D + LLL
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 266 QHGASIHDRDAKGETPISIA 285
GA+IH G T + +A
Sbjct: 683 DKGANIHMSTKSGLTSLHLA 702
Score = 50.4 bits (119), Expect = 2e-06
Identities = 32/96 (33%), Positives = 53/96 (55%), Gaps = 2/96 (2%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++ ++VA+ GH + V LL++GAS + G T LH+AA G+ + + LL++G
Sbjct: 428 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Query: 269 ASIHDRDAKGETPISIAHCLNHTLSERQMVLLHRIA 304
A + R + +TP+ IA L T E +LL +A
Sbjct: 488 ALVDARAREEQTPLHIASRLGKT--EIVQLLLQHMA 521
Score = 46.6 bits (109), Expect = 3e-05
Identities = 25/86 (29%), Positives = 43/86 (50%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H +++ +L++A+ + L +HGA + + LG TPL VA G + LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 266 QHGASIHDRDAKGETPISIAHCLNHT 291
+ GA+++ + G TP+ A HT
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHT 774
Score = 45.1 bits (105), Expect = 9e-05
Identities = 25/77 (32%), Positives = 40/77 (51%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ L++AS GH D V LL+ GA+ + G T LH+AA + + +L +HG
Sbjct: 659 TKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG 718
Query: 269 ASIHDRDAKGETPISIA 285
A G TP+ +A
Sbjct: 719 ADQDAHTKLGYTPLIVA 735
Score = 37.7 bits (86), Expect = 0.015
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 6/102 (5%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ H + V++LL+H A + T LHVAA G LLL A+ + R
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 276 AKGETPISIAHCLNHTLSERQMVL-----LHRIAKSGIRDLN 312
G TP+ IA C + + ++++ + I +SG+ ++
Sbjct: 396 LNGFTPLHIA-CKKNRIKVMELLVKYGASIQAITESGLTPIH 436
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 55.8 bits (133), Expect = 5e-08
Identities = 42/137 (30%), Positives = 61/137 (44%), Gaps = 21/137 (15%)
Query: 163 DGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHR 222
D WT L+ A+ EG + + E+ N EH + W AL A ++
Sbjct: 70 DNWTALISASKEGH------VHIVEELLKCGVNLEHRDMGGW---------TALMWACYK 114
Query: 223 GHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPI 282
G D V+ LL HGA+ P+ AA G +D + LLLQ+GA ++ D G TP+
Sbjct: 115 GRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPL 174
Query: 283 SIA------HCLNHTLS 293
A C+ H L+
Sbjct: 175 VWAARKGHLECVKHLLA 191
Score = 42.0 bits (97), Expect = 8e-04
Identities = 34/107 (31%), Positives = 49/107 (45%), Gaps = 15/107 (14%)
Query: 164 GWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRG 223
G T L++AA +G+ L + ++ AN + + W AL AS G
Sbjct: 38 GQTPLMIAAEQGN------LEIVKELIKNGANCNLEDLDNW---------TALISASKEG 82
Query: 224 HFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGAS 270
H V+ LL+ G + R G T L A GR+D + LLL HGA+
Sbjct: 83 HVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGAN 129
Score = 39.7 bits (91), Expect = 0.004
Identities = 25/71 (35%), Positives = 36/71 (50%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
ALY A +G+ V+ +L+ + G TPL A M + + LLL GA +
Sbjct: 305 ALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAV 364
Query: 275 DAKGETPISIA 285
D KG+TP+ IA
Sbjct: 365 DKKGDTPLHIA 375
Score = 35.4 bits (80), Expect = 0.073
Identities = 21/73 (28%), Positives = 34/73 (46%)
Query: 219 ASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKG 278
A+ +GH + V++LL GA T L VA G + + +L+ +++ D G
Sbjct: 177 AARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDG 236
Query: 279 ETPISIAHCLNHT 291
T + IA HT
Sbjct: 237 NTALMIASKEGHT 249
Score = 30.8 bits (68), Expect = 1.8
Identities = 24/75 (32%), Positives = 32/75 (42%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T + AL +AS GH + VQ LL+ G G T L A G + + LLQ
Sbjct: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQK 291
Query: 268 GASIHDRDAKGETPI 282
A I R +T +
Sbjct: 292 YADIDIRGQDNKTAL 306
Score = 30.4 bits (67), Expect = 2.3
Identities = 19/64 (29%), Positives = 32/64 (50%)
Query: 227 AVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAH 286
A++ LLE R+ G+TPL +AA G + + L+++GA+ + D T + A
Sbjct: 20 ALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79
Query: 287 CLNH 290
H
Sbjct: 80 KEGH 83
Score = 29.3 bits (64), Expect = 5.2
Identities = 18/69 (26%), Positives = 33/69 (47%)
Query: 212 AFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASI 271
+ AL VA G+ +V+ +L+ + G T L +A+ G ++ + LL G +
Sbjct: 203 SMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYV 262
Query: 272 HDRDAKGET 280
+ D G+T
Sbjct: 263 NIPDRSGDT 271
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 55.5 bits (132), Expect = 7e-08
Identities = 41/123 (33%), Positives = 63/123 (51%), Gaps = 15/123 (12%)
Query: 164 GWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTSQRAFVALYVASHRG 223
G T L AA+ GD ++ L ++E + N + F G WT AL+ A +RG
Sbjct: 168 GETRLHRAAIRGDARRIKEL-ISEGA---DVNVKDFAG-----WT------ALHEACNRG 212
Query: 224 HFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPIS 283
++D + LL GA ++ TPLH AA G + LLL++G + + KGETP+
Sbjct: 213 YYDVAKQLLAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLK 272
Query: 284 IAH 286
+A+
Sbjct: 273 VAN 275
Score = 33.1 bits (74), Expect = 0.36
Identities = 21/74 (28%), Positives = 34/74 (45%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
++R L+ A+ RG ++ L+ GA + G T LH A G D LL G
Sbjct: 165 NERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQLLAAG 224
Query: 269 ASIHDRDAKGETPI 282
A ++ + +TP+
Sbjct: 225 AEVNTKGLDDDTPL 238
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 55.5 bits (132), Expect = 7e-08
Identities = 33/88 (37%), Positives = 48/88 (54%), Gaps = 1/88 (1%)
Query: 214 VALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHD 273
V L++A +GHF V+ LL+ A + G TPL A + G + + LLLQHGASI+
Sbjct: 779 VPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINA 838
Query: 274 RDAKGETPISIAHCLNHTLSERQMVLLH 301
+ KG T + A H +++LLH
Sbjct: 839 SNNKGNTALHEAVIEKHVFVV-ELLLLH 865
Score = 48.1 bits (113), Expect = 1e-05
Identities = 27/78 (34%), Positives = 39/78 (50%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
TSQ L+VA+ G D + LL+HGA+ +R+ PLH+A G + LL
Sbjct: 740 TSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVPLHLACQQGHFQVVKCLLDS 799
Query: 268 GASIHDRDAKGETPISIA 285
A + +D G TP+ A
Sbjct: 800 NAKPNKKDLSGNTPLIYA 817
Score = 46.2 bits (108), Expect = 4e-05
Identities = 27/73 (36%), Positives = 39/73 (53%), Gaps = 2/73 (2%)
Query: 240 SRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNHTLSERQMVL 299
SR G TPLHVAA G++ I LL+ GA ++ D G TP+ +A ++L
Sbjct: 458 SRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLA--CQKGYQSVTLLL 515
Query: 300 LHRIAKSGIRDLN 312
LH A + ++D N
Sbjct: 516 LHYKASAEVQDNN 528
Score = 45.1 bits (105), Expect = 9e-05
Identities = 26/80 (32%), Positives = 37/80 (46%)
Query: 211 RAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGAS 270
R L+VA+ G + L+ GA + G TPLH+A G +LLL + AS
Sbjct: 462 RGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKAS 521
Query: 271 IHDRDAKGETPISIAHCLNH 290
+D G TP+ +A H
Sbjct: 522 AEVQDNNGNTPLHLACTYGH 541
Score = 42.0 bits (97), Expect = 8e-04
Identities = 24/81 (29%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T L++A +G+ LL + AS + G TPLH+A G DC+ L+ +
Sbjct: 492 TDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYY 551
Query: 268 ---GASIHDRDAKGETPISIA 285
+ + KG+TP+ IA
Sbjct: 552 DVESCRLDIGNEKGDTPLHIA 572
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 6/99 (6%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L A GH + V LL+HGAS + + G T LH A + LLL HGAS+ +
Sbjct: 814 LIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLN 873
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRDLNDL 314
+ T + A +++ L ++ S + L+D+
Sbjct: 874 KRQRTAVDCAE------QNSKIMELLQVVPSCVASLDDV 906
Score = 40.0 bits (92), Expect = 0.003
Identities = 28/73 (38%), Positives = 39/73 (53%), Gaps = 3/73 (4%)
Query: 216 LYVASHRGHFDAVQYLLEHGA-SCLSR--SPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
L++A GH D V+ L+ + SC + G TPLH+AA G I LLQ+GAS
Sbjct: 533 LHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTE 592
Query: 273 DRDAKGETPISIA 285
++ ETP+ A
Sbjct: 593 IQNRLKETPLKCA 605
Score = 29.3 bits (64), Expect = 5.2
Identities = 18/74 (24%), Positives = 36/74 (48%), Gaps = 3/74 (4%)
Query: 209 SQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHG 268
+++ L++A+ G+ ++ LL++GAS ++ L TPL A S + ++ +
Sbjct: 562 NEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCAL---NSKILSVMEAYH 618
Query: 269 ASIHDRDAKGETPI 282
S R E P+
Sbjct: 619 LSFERRQKSSEAPV 632
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 55.1 bits (131), Expect = 9e-08
Identities = 35/77 (45%), Positives = 41/77 (53%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A RGH V+ LL+ GA + GRT LH AA G S LLLQ GAS R
Sbjct: 78 LHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARS 137
Query: 276 AKGETPISIAHCLNHTL 292
G TP+ A L HTL
Sbjct: 138 GTGLTPLHWAAALGHTL 154
Score = 51.2 bits (121), Expect = 1e-06
Identities = 33/84 (39%), Positives = 46/84 (54%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL VA+ G A+++LL GA +R G T L +AAA+GRS I +LL HGA R
Sbjct: 206 ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIR 265
Query: 275 DAKGETPISIAHCLNHTLSERQMV 298
D G + + A H L+ + +V
Sbjct: 266 DRHGRSALHRAAARGHLLAVQLLV 289
Score = 48.5 bits (114), Expect = 8e-06
Identities = 36/94 (38%), Positives = 43/94 (45%), Gaps = 2/94 (2%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L A RG V LL GAS R GRTPLH+A G + + LLLQ GA + D
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVD 104
Query: 276 AKGETPISIAHCLNHTLSERQMVLLHRIAKSGIR 309
G T + A H S +LL R A + R
Sbjct: 105 RAGRTALHEAAWHGH--SRVAELLLQRGASAAAR 136
Score = 47.0 bits (110), Expect = 2e-05
Identities = 28/71 (39%), Positives = 38/71 (53%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL+ A+ RGH AVQ L+ GA +R LG TPLH A+ G + LL GA +
Sbjct: 272 ALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDAT 331
Query: 275 DAKGETPISIA 285
+TP+ +A
Sbjct: 332 GWLRKTPLHLA 342
Score = 44.7 bits (104), Expect = 1e-04
Identities = 29/76 (38%), Positives = 38/76 (50%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDR 274
AL +A+ G ++ LL HGA R GR+ LH AAA G + LL+ GA + R
Sbjct: 239 ALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDAR 298
Query: 275 DAKGETPISIAHCLNH 290
D G TP+ A H
Sbjct: 299 DTLGLTPLHHASREGH 314
Score = 43.9 bits (102), Expect = 2e-04
Identities = 28/70 (40%), Positives = 38/70 (54%), Gaps = 4/70 (5%)
Query: 215 ALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQ----HGAS 270
AL+ A+ GH + LL+ GAS +RS G TPLH AAA+G + LL+ A+
Sbjct: 110 ALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAA 169
Query: 271 IHDRDAKGET 280
DA+G T
Sbjct: 170 AEAEDARGWT 179
Score = 42.0 bits (97), Expect = 8e-04
Identities = 23/55 (41%), Positives = 30/55 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGAS 270
L+ AS GH + LL+ GA + L +TPLH+AA G + LLL GAS
Sbjct: 306 LHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 54.7 bits (130), Expect = 1e-07
Identities = 30/72 (41%), Positives = 39/72 (54%)
Query: 214 VALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHD 273
+ L+ A GH + V LL HGA +R TPLH AA G+ D I+LLQHGA
Sbjct: 93 IPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTI 152
Query: 274 RDAKGETPISIA 285
R+ G T + +A
Sbjct: 153 RNTDGRTALDLA 164
Score = 54.3 bits (129), Expect = 2e-07
Identities = 29/75 (38%), Positives = 44/75 (58%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T+ R L+ A+ G D V+YLL++GA+ +R G PLH A + G ++ + LLL+H
Sbjct: 54 TAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRH 113
Query: 268 GASIHDRDAKGETPI 282
GA + RD TP+
Sbjct: 114 GADPNARDNWNYTPL 128
Score = 51.6 bits (122), Expect = 1e-06
Identities = 28/79 (35%), Positives = 41/79 (51%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H + V L+ A GH++ + L++HGA TPLH AAA G+ + LLL
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Query: 266 QHGASIHDRDAKGETPISI 284
QHGA ++ G TP+ +
Sbjct: 613 QHGADPTKKNRDGNTPLDL 631
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/132 (28%), Positives = 57/132 (43%), Gaps = 16/132 (12%)
Query: 211 RAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGA- 269
R L+ A+ V+YLL+HGA ++ G PLH A + G + LL++HGA
Sbjct: 525 RQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAV 584
Query: 270 ----------SIHDRDAKGETPIS---IAHCLNHTLSERQMVLLHRIAKSGIRDLNDLVM 316
+H+ AKG+ I + H + T R + K G D+ DL+
Sbjct: 585 VNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLR 644
Query: 317 KNA--LQRVKSG 326
+A L K G
Sbjct: 645 GDAALLDAAKKG 656
Score = 47.0 bits (110), Expect = 2e-05
Identities = 24/71 (33%), Positives = 38/71 (53%)
Query: 214 VALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHD 273
+ L+ A+ GH D L+++ A + TPLH AA GR+ LLL HGA
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL 773
Query: 274 RDAKGETPISI 284
++ +G+TP+ +
Sbjct: 774 KNQEGQTPLDL 784
Score = 46.2 bits (108), Expect = 4e-05
Identities = 24/75 (32%), Positives = 40/75 (53%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
T R L++A+ + + +YLL+HGA ++ G PLH AA+ G D LL+++
Sbjct: 675 TQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKY 734
Query: 268 GASIHDRDAKGETPI 282
A ++ D TP+
Sbjct: 735 NACVNATDKWAFTPL 749
Score = 44.3 bits (103), Expect = 2e-04
Identities = 35/97 (36%), Positives = 46/97 (47%), Gaps = 5/97 (5%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGR--TPLHVAAAMGRSDCIILLLQHGASIHD 273
L+ A G + V+ L+ SR GR TPLH AA GR D + LLQ+GA++
Sbjct: 28 LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQA 86
Query: 274 RDAKGETPISIAHCLNHTLSERQMVLLHRIAKSGIRD 310
RD G P+ A H +E +LL A RD
Sbjct: 87 RDDGGLIPLHNACSFGH--AEVVNLLLRHGADPNARD 121
Score = 42.4 bits (98), Expect = 6e-04
Identities = 26/84 (30%), Positives = 40/84 (47%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLL 265
H + R L++A+ VQ LL+HGA ++ PLH A + G + LL+
Sbjct: 205 HASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 264
Query: 266 QHGASIHDRDAKGETPISIAHCLN 289
+HGA ++ D TP+ A N
Sbjct: 265 KHGACVNAMDLWQFTPLHEAASKN 288
Score = 40.4 bits (93), Expect = 0.002
Identities = 24/65 (36%), Positives = 37/65 (56%), Gaps = 2/65 (3%)
Query: 206 HWTSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGR-TPLHVAAAMGRSDCIILL 264
H + V L+ A GH++ + L++HGA C++ L + TPLH AA+ R + LL
Sbjct: 238 HAKDKGDLVPLHNACSYGHYEVTELLVKHGA-CVNAMDLWQFTPLHEAASKNRVEVCSLL 296
Query: 265 LQHGA 269
L +GA
Sbjct: 297 LSYGA 301
Score = 40.4 bits (93), Expect = 0.002
Identities = 23/71 (32%), Positives = 37/71 (52%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L+VAS + H D V+ +++H A + LG+T LH AA G LLL +G +
Sbjct: 404 LHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS 463
Query: 276 AKGETPISIAH 286
+G T + + +
Sbjct: 464 LQGFTALQMGN 474
Score = 39.3 bits (90), Expect = 0.005
Identities = 19/44 (43%), Positives = 24/44 (54%)
Query: 247 TPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCLNH 290
TPLH+AA R + LLLQHGA +H +D P+ A H
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGH 256
Score = 36.2 bits (82), Expect = 0.043
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 1/81 (1%)
Query: 211 RAFVALYVASHRGHFDAVQYLLE-HGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGA 269
R AL A+ +G V+ L +C TPLH+AA + LLQHGA
Sbjct: 644 RGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGA 703
Query: 270 SIHDRDAKGETPISIAHCLNH 290
++ +D G P+ A H
Sbjct: 704 DVNAQDKGGLIPLHNAASYGH 724
Score = 35.0 bits (79), Expect = 0.095
Identities = 18/62 (29%), Positives = 33/62 (53%)
Query: 229 QYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIAHCL 288
+ LL GA+ ++ TPLHVA+ +D + ++++H A ++ D G+T + A
Sbjct: 384 ELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYC 443
Query: 289 NH 290
H
Sbjct: 444 GH 445
Score = 32.0 bits (71), Expect = 0.81
Identities = 32/142 (22%), Positives = 54/142 (38%), Gaps = 36/142 (25%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVA-------------------- 252
+ L+ A+ +G D LL+HGA R+ GRT L +A
Sbjct: 125 YTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLES 184
Query: 253 AAMGRSDCIILLLQH-GASIHDRDAKGETPISIAHCLN---------------HTLSERQ 296
A G + ++ LL + H D + TP+ +A N H +
Sbjct: 185 ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244
Query: 297 MVLLHRIAKSGIRDLNDLVMKN 318
+V LH G ++ +L++K+
Sbjct: 245 LVPLHNACSYGHYEVTELLVKH 266
Score = 31.2 bits (69), Expect = 1.4
Identities = 16/47 (34%), Positives = 25/47 (53%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAA 254
T + AF L+ A+ +G LL HGA ++ G+TPL + +A
Sbjct: 741 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
>gi|156142184 ankyrin repeat domain 39 [Homo sapiens]
Length = 183
Score = 54.7 bits (130), Expect = 1e-07
Identities = 36/104 (34%), Positives = 52/104 (50%), Gaps = 13/104 (12%)
Query: 213 FVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIH 272
+ AL+ AS GH+ Q+LLE GA C +++ G T LH A+ G ++ LLL HG++
Sbjct: 65 YTALHYASRNGHYAVCQFLLESGAKCDAQTHGGATALHRASYCGHTEIARLLLSHGSNPR 124
Query: 273 DRDAKGETPISIAHCLNHTLSER------QMVLLHRIAKSGIRD 310
D G T + H +ER ++L H A IRD
Sbjct: 125 VVDDDGMTSL-------HKAAERGHGDICSLLLQHSPALKAIRD 161
>gi|52486194 phospholipase A2, group VI isoform a [Homo sapiens]
Length = 806
Score = 54.3 bits (129), Expect = 2e-07
Identities = 32/95 (33%), Positives = 48/95 (50%)
Query: 208 TSQRAFVALYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQH 267
TS AL+VA R FD LL HGA+ +R G TPLH+A + + I L+
Sbjct: 313 TSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVF 372
Query: 268 GASIHDRDAKGETPISIAHCLNHTLSERQMVLLHR 302
GA + + GETP +A + ++ + ++ L R
Sbjct: 373 GAEVDTPNDFGETPTFLASKIGRLVTRKAILTLLR 407
Score = 49.7 bits (117), Expect = 4e-06
Identities = 25/60 (41%), Positives = 33/60 (55%)
Query: 226 DAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGETPISIA 285
+ + LL+ G + S S G T LHVA R DC I+LL HGA+ R G TP+ +A
Sbjct: 298 EMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFDCAIVLLTHGANADARGEHGNTPLHLA 357
Score = 30.8 bits (68), Expect = 1.8
Identities = 22/70 (31%), Positives = 37/70 (52%), Gaps = 4/70 (5%)
Query: 245 GRTPLHVAAAMGRSDCIILLLQHGASIHD-RDAKGETPISIAHCLNHTLSERQMVLLHRI 303
G TPLH+A G + ++ L+Q+ + D D KGET + H + + + LL R
Sbjct: 152 GCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGET---VFHYAVQGDNSQVLQLLGRN 208
Query: 304 AKSGIRDLND 313
A +G+ +N+
Sbjct: 209 AVAGLNQVNN 218
>gi|41350198 fetal globin inducing factor [Homo sapiens]
Length = 239
Score = 54.3 bits (129), Expect = 2e-07
Identities = 40/151 (26%), Positives = 69/151 (45%), Gaps = 5/151 (3%)
Query: 162 HDGWTELVLAAVEGDPSKLSCLGLTEDSFYRTANSEHFEGEKWKHWTS--QRAFVALYVA 219
++ W L +E DPS+L ++ R EK H + + + L+ A
Sbjct: 59 NEEWYRLQEKKMEKDPSRLLLWAAEKN---RLTTVRRLLSEKATHVNTRDEDEYTPLHRA 115
Query: 220 SHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRDAKGE 279
++ GH D VQ L+ GA + + G TPLH A + LLQH A I+ +
Sbjct: 116 AYSGHLDIVQELIAQGADVHAVTVDGWTPLHSACKWNNTRVASFLLQHDADINAQTKGLL 175
Query: 280 TPISIAHCLNHTLSERQMVLLHRIAKSGIRD 310
TP+ +A + +++L++R K G+++
Sbjct: 176 TPLHLAAGNRDSKDTLELLLMNRYVKPGLKN 206
>gi|8051593 GA binding protein transcription factor, beta subunit 1
isoform beta 1 [Homo sapiens]
Length = 395
Score = 53.9 bits (128), Expect = 2e-07
Identities = 27/75 (36%), Positives = 45/75 (60%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH+ + LL G S +R+ + RTPLH+AA+ G + + +LL+HGA ++ +D
Sbjct: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
Query: 276 AKGETPISIAHCLNH 290
T + A NH
Sbjct: 102 MLKMTALHWATEHNH 116
Score = 44.7 bits (104), Expect = 1e-04
Identities = 22/70 (31%), Positives = 38/70 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH V+ LL+HGA ++ L T LH A + + LL+++GA +H +
Sbjct: 75 LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQS 134
Query: 276 AKGETPISIA 285
+T I+
Sbjct: 135 KFCKTAFDIS 144
Score = 36.6 bits (83), Expect = 0.033
Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L A+ G D V+ L+ +GA + LG +PLH+AA G +LL+ G S R
Sbjct: 10 LLEAARAGQDDEVRILMANGAP-FTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
Query: 276 AKGETPISIAHCLNH 290
TP+ +A H
Sbjct: 69 KVDRTPLHMAASEGH 83
>gi|8051595 GA binding protein transcription factor, beta subunit 1
isoform beta 2 [Homo sapiens]
Length = 383
Score = 53.9 bits (128), Expect = 2e-07
Identities = 27/75 (36%), Positives = 45/75 (60%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH+ + LL G S +R+ + RTPLH+AA+ G + + +LL+HGA ++ +D
Sbjct: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
Query: 276 AKGETPISIAHCLNH 290
T + A NH
Sbjct: 102 MLKMTALHWATEHNH 116
Score = 44.7 bits (104), Expect = 1e-04
Identities = 22/70 (31%), Positives = 38/70 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH V+ LL+HGA ++ L T LH A + + LL+++GA +H +
Sbjct: 75 LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQS 134
Query: 276 AKGETPISIA 285
+T I+
Sbjct: 135 KFCKTAFDIS 144
Score = 36.6 bits (83), Expect = 0.033
Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L A+ G D V+ L+ +GA + LG +PLH+AA G +LL+ G S R
Sbjct: 10 LLEAARAGQDDEVRILMANGAP-FTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
Query: 276 AKGETPISIAHCLNH 290
TP+ +A H
Sbjct: 69 KVDRTPLHMAASEGH 83
>gi|32483404 GA binding protein transcription factor, beta subunit 1
isoform gamma 2 [Homo sapiens]
Length = 348
Score = 53.9 bits (128), Expect = 2e-07
Identities = 27/75 (36%), Positives = 45/75 (60%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH+ + LL G S +R+ + RTPLH+AA+ G + + +LL+HGA ++ +D
Sbjct: 42 LHLAAQYGHYSTTEVLLRAGVSRDARTKVDRTPLHMAASEGHASIVEVLLKHGADVNAKD 101
Query: 276 AKGETPISIAHCLNH 290
T + A NH
Sbjct: 102 MLKMTALHWATEHNH 116
Score = 44.7 bits (104), Expect = 1e-04
Identities = 22/70 (31%), Positives = 38/70 (54%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L++A+ GH V+ LL+HGA ++ L T LH A + + LL+++GA +H +
Sbjct: 75 LHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQS 134
Query: 276 AKGETPISIA 285
+T I+
Sbjct: 135 KFCKTAFDIS 144
Score = 36.6 bits (83), Expect = 0.033
Identities = 25/75 (33%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
Query: 216 LYVASHRGHFDAVQYLLEHGASCLSRSPLGRTPLHVAAAMGRSDCIILLLQHGASIHDRD 275
L A+ G D V+ L+ +GA + LG +PLH+AA G +LL+ G S R
Sbjct: 10 LLEAARAGQDDEVRILMANGAP-FTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDART 68
Query: 276 AKGETPISIAHCLNH 290
TP+ +A H
Sbjct: 69 KVDRTPLHMAASEGH 83
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,498,005
Number of Sequences: 37866
Number of extensions: 646010
Number of successful extensions: 5447
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 342
Number of HSP's successfully gapped in prelim test: 159
Number of HSP's that attempted gapping in prelim test: 3370
Number of HSP's gapped (non-prelim): 1918
length of query: 337
length of database: 18,247,518
effective HSP length: 103
effective length of query: 234
effective length of database: 14,347,320
effective search space: 3357272880
effective search space used: 3357272880
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.