Search of human proteins with 118498337

Search of human proteins with 118498337

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|118498337 HECT domain containing 1 [Homo sapiens]
         (2610 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|118498337 HECT domain containing 1 [Homo sapiens]                 5222   0.0  
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]     179   4e-44
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...   119   3e-26
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]     115   4e-25
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]     115   4e-25
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]     115   4e-25
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i...   113   3e-24
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i...   113   3e-24
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [...   112   4e-24
gi|222352183 neural precursor cell expressed, developmentally do...   107   1e-22
gi|21361472 neural precursor cell expressed, developmentally dow...   107   1e-22
gi|222352094 neural precursor cell expressed, developmentally do...   107   1e-22
gi|222352092 neural precursor cell expressed, developmentally do...   107   1e-22
gi|222352090 neural precursor cell expressed, developmentally do...   107   1e-22
gi|222352088 neural precursor cell expressed, developmentally do...   107   1e-22
gi|222352086 neural precursor cell expressed, developmentally do...   107   1e-22
gi|222352084 neural precursor cell expressed, developmentally do...   107   1e-22
gi|222352082 neural precursor cell expressed, developmentally do...   107   1e-22
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]              106   3e-22
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi...   105   8e-22
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]       98   9e-20
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa...    93   4e-18
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      91   1e-17
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]         89   4e-17
gi|114520609 neural precursor cell expressed, developmentally do...    89   6e-17
gi|114520607 neural precursor cell expressed, developmentally do...    89   6e-17
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H...    83   3e-15
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H...    83   3e-15
gi|7657152 hect domain and RLD 3 [Homo sapiens]                        83   3e-15
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]                82   5e-15

>gi|118498337 HECT domain containing 1 [Homo sapiens]
          Length = 2610

 Score = 5222 bits (13547), Expect = 0.0
 Identities = 2610/2610 (100%), Positives = 2610/2610 (100%)

Query: 1    MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKI 60
            MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKI
Sbjct: 1    MADVDPDTLLEWLQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKI 60

Query: 61   FLDESAPDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLA 120
            FLDESAPDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLA
Sbjct: 61   FLDESAPDNVLEVTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLA 120

Query: 121  EQCVKVLELICTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQ 180
            EQCVKVLELICTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQ
Sbjct: 121  EQCVKVLELICTRESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQ 180

Query: 181  DSSLEICVESLSSLLKHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRM 240
            DSSLEICVESLSSLLKHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRM
Sbjct: 181  DSSLEICVESLSSLLKHEDHQVSDGALRCFASLADRFTRRGVDPAPLAKHGLTEELLSRM 240

Query: 241  AAAGGTVSGPSSACKPGRSTTGAPSTTADSKLSNQVSTIVSLLSTLCRGSPVVTHDLLRS 300
            AAAGGTVSGPSSACKPGRSTTGAPSTTADSKLSNQVSTIVSLLSTLCRGSPVVTHDLLRS
Sbjct: 241  AAAGGTVSGPSSACKPGRSTTGAPSTTADSKLSNQVSTIVSLLSTLCRGSPVVTHDLLRS 300

Query: 301  ELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAGSTGRIPGLRRLDSSGE 360
            ELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAGSTGRIPGLRRLDSSGE
Sbjct: 301  ELPDSIESALQGDERCVLDTMRLVDLLLVLLFEGRKALPKSSAGSTGRIPGLRRLDSSGE 360

Query: 361  RSHRQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGA 420
            RSHRQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGA
Sbjct: 361  RSHRQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCERGA 420

Query: 421  DVNRGQRSSSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQ 480
            DVNRGQRSSSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQ
Sbjct: 421  DVNRGQRSSSLHYAACFGRPQVAKTLLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQ 480

Query: 481  SPGDWMCPVNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSI 540
            SPGDWMCPVNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSI
Sbjct: 481  SPGDWMCPVNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSI 540

Query: 541  RKASLALIRKMIHFCSEALLKEVCDSDVGHNLPTILVEITATVLDQEDDDDGHLLALQII 600
            RKASLALIRKMIHFCSEALLKEVCDSDVGHNLPTILVEITATVLDQEDDDDGHLLALQII
Sbjct: 541  RKASLALIRKMIHFCSEALLKEVCDSDVGHNLPTILVEITATVLDQEDDDDGHLLALQII 600

Query: 601  RDLVDKGGDIFLDQLARLGVISKVSTLAGPSSDDENEEESKPEKEDEPQEDAKELQQGKP 660
            RDLVDKGGDIFLDQLARLGVISKVSTLAGPSSDDENEEESKPEKEDEPQEDAKELQQGKP
Sbjct: 601  RDLVDKGGDIFLDQLARLGVISKVSTLAGPSSDDENEEESKPEKEDEPQEDAKELQQGKP 660

Query: 661  YHWRDWSIIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSES 720
            YHWRDWSIIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSES
Sbjct: 661  YHWRDWSIIRGRDCLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGSPEGGSDSSES 720

Query: 721  RSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATI 780
            RSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATI
Sbjct: 721  RSEFLEKLQRARGQVKPSTSSQPILSAPGPTKLTVGNWSLTCLKEGEIAIHNSDGQQATI 780

Query: 781  LKEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDL 840
            LKEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDL
Sbjct: 781  LKEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKRGRKLKSKLEKTKQKVRTMARDL 840

Query: 841  YDDHFKAVESMPRGVVVTLRNIATQLESSWELHTNRQCIESENTWRDLMKTALENLIVLL 900
            YDDHFKAVESMPRGVVVTLRNIATQLESSWELHTNRQCIESENTWRDLMKTALENLIVLL
Sbjct: 841  YDDHFKAVESMPRGVVVTLRNIATQLESSWELHTNRQCIESENTWRDLMKTALENLIVLL 900

Query: 901  KDENTISPYEMCSSGLVQALLTVLNNSMDLDMKQDCSQLVERINVFKTAFSENEDDESRP 960
            KDENTISPYEMCSSGLVQALLTVLNNSMDLDMKQDCSQLVERINVFKTAFSENEDDESRP
Sbjct: 901  KDENTISPYEMCSSGLVQALLTVLNNSMDLDMKQDCSQLVERINVFKTAFSENEDDESRP 960

Query: 961  AVALIRKLIAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETALIDRTGRML 1020
            AVALIRKLIAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETALIDRTGRML
Sbjct: 961  AVALIRKLIAVLESIERLPLHLYDTPGSTYNLQILTRRLRFRLERAPGETALIDRTGRML 1020

Query: 1021 KMEPLATVESLEQYLLKMVAKQWYDFDRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWI 1080
            KMEPLATVESLEQYLLKMVAKQWYDFDRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWI
Sbjct: 1021 KMEPLATVESLEQYLLKMVAKQWYDFDRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWI 1080

Query: 1081 GTNAKTAYEWVNPAAYGLVVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAID 1140
            GTNAKTAYEWVNPAAYGLVVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAID
Sbjct: 1081 GTNAKTAYEWVNPAAYGLVVVTSSEGRNLPYGRLEDILSRDNSALNCHSNDDKNAWFAID 1140

Query: 1141 LGLWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPL 1200
            LGLWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPL
Sbjct: 1141 LGLWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQNWTSLYTHVDDCSLNEPGSTATWPL 1200

Query: 1201 DPPKDEKQGWRHVRIKQMGKNASGQTHYLSLSGFELYGTVNGVCEDQLGKAAKEAEANLR 1260
            DPPKDEKQGWRHVRIKQMGKNASGQTHYLSLSGFELYGTVNGVCEDQLGKAAKEAEANLR
Sbjct: 1201 DPPKDEKQGWRHVRIKQMGKNASGQTHYLSLSGFELYGTVNGVCEDQLGKAAKEAEANLR 1260

Query: 1261 RQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVTGELHNGWIDVTWDAGGSN 1320
            RQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVTGELHNGWIDVTWDAGGSN
Sbjct: 1261 RQRRLVRSQVLKYMVPGARVIRGLDWKWRDQDGSPQGEGTVTGELHNGWIDVTWDAGGSN 1320

Query: 1321 SYRMGAEGKFDLKLAPGYDPDTVASPKPVSSTVSGTTQSWSSLVKNNCPDKTSAAAGSSS 1380
            SYRMGAEGKFDLKLAPGYDPDTVASPKPVSSTVSGTTQSWSSLVKNNCPDKTSAAAGSSS
Sbjct: 1321 SYRMGAEGKFDLKLAPGYDPDTVASPKPVSSTVSGTTQSWSSLVKNNCPDKTSAAAGSSS 1380

Query: 1381 RKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEV 1440
            RKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEV
Sbjct: 1381 RKGSSSSVCSVASSSDISLGSTKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEV 1440

Query: 1441 GSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVSSVSELTNK 1500
            GSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVSSVSELTNK
Sbjct: 1441 GSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVSSVSELTNK 1500

Query: 1501 EAASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNA 1560
            EAASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNA
Sbjct: 1501 EAASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNA 1560

Query: 1561 TNNMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSN 1620
            TNNMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSN
Sbjct: 1561 TNNMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSN 1620

Query: 1621 VATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDED 1680
            VATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDED
Sbjct: 1621 VATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDED 1680

Query: 1681 LPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPAGAGS 1740
            LPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPAGAGS
Sbjct: 1681 LPEPDEEDDENEDDNQEDQEYEEVMILRRPSLQRRAGSRSDVTHHAVTSQLPQVPAGAGS 1740

Query: 1741 RPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT 1800
            RPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT
Sbjct: 1741 RPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTDLEIPPPGT 1800

Query: 1801 PHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVK 1860
            PHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVK
Sbjct: 1801 PHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLTNFRSTIFYYVQKLLQLSCNGNVK 1860

Query: 1861 SDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKN 1920
            SDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKN
Sbjct: 1861 SDKLRRIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKN 1920

Query: 1921 ADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLT 1980
            ADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLT
Sbjct: 1921 ADAAFLRHWKLTGTNKSIRKNRNCSQLIAAYKDFCEHGTKSGLNQGAISTLQSSDILNLT 1980

Query: 1981 KEQPQAKAGNGQNSCGVEDVLQLLRILYIVASDPYSRISQEDGDEQLQFTFPPDEFTSKK 2040
            KEQPQAKAGNGQNSCGVEDVLQLLRILYIVASDPYSRISQEDGDEQLQFTFPPDEFTSKK
Sbjct: 1981 KEQPQAKAGNGQNSCGVEDVLQLLRILYIVASDPYSRISQEDGDEQLQFTFPPDEFTSKK 2040

Query: 2041 ITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQN 2100
            ITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQN
Sbjct: 2041 ITTKILQQIEEPLALASGALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQN 2100

Query: 2101 RREATVERTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLE 2160
            RREATVERTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLE
Sbjct: 2101 RREATVERTRTTSSVRRDDPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLE 2160

Query: 2161 VEFLGEEGTGLGPTLEFYALVAAEFQRTDLGAWLCDDNFPDDESRHVDLGGGLKPPGYYV 2220
            VEFLGEEGTGLGPTLEFYALVAAEFQRTDLGAWLCDDNFPDDESRHVDLGGGLKPPGYYV
Sbjct: 2161 VEFLGEEGTGLGPTLEFYALVAAEFQRTDLGAWLCDDNFPDDESRHVDLGGGLKPPGYYV 2220

Query: 2221 QRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMCMGDIK 2280
            QRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMCMGDIK
Sbjct: 2221 QRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMCMGDIK 2280

Query: 2281 SNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWF 2340
            SNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWF
Sbjct: 2281 SNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSEFILDPPKPKPPAWF 2340

Query: 2341 NGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSG 2400
            NGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSG
Sbjct: 2341 NGILTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSG 2400

Query: 2401 PPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQK 2460
            PPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQK
Sbjct: 2401 PPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQK 2460

Query: 2461 QMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGF 2520
            QMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGF
Sbjct: 2461 QMEAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGF 2520

Query: 2521 LRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCV 2580
            LRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCV
Sbjct: 2521 LRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCV 2580

Query: 2581 HYLKLPEYSSEEIMRERLLAATMEKGFHLN 2610
            HYLKLPEYSSEEIMRERLLAATMEKGFHLN
Sbjct: 2581 HYLKLPEYSSEEIMRERLLAATMEKGFHLN 2610


>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
          Length = 1992

 Score =  179 bits (453), Expect = 4e-44
 Identities = 99/273 (36%), Positives = 158/273 (57%), Gaps = 19/273 (6%)

Query: 2344 LTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSGPPL 2403
            LT  D   ++P  AR +  ++D+  +++++  +K  +++     L+ L +          
Sbjct: 1733 LTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNG-------C 1785

Query: 2404 SIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQME 2463
            S+EDLGL+F       + GF  ++LK  G+D  +T+ N EEY+ L+  + ++ G+ +Q +
Sbjct: 1786 SVEDLGLDFT------LPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFD 1839

Query: 2464 AFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRF 2523
            +FRDGF  VFP+  L  F  EE+  +LCG+++ +W A+ ++    P  GYT DS      
Sbjct: 1840 SFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFL 1899

Query: 2524 VRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRK----VDATDASYPSVNTC 2579
              +L    +++++ FLQF TG   LP GG  +L+P LT+VRK     +  D   PSV TC
Sbjct: 1900 FEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTC 1959

Query: 2580 VHYLKLPEYSSEEIMRERLLAATME--KGFHLN 2610
            V+YLKLP+YSS EIMRE+LL A  E  + FHL+
Sbjct: 1960 VNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS 1992



 Score =  162 bits (410), Expect = 4e-39
 Identities = 113/350 (32%), Positives = 173/350 (49%), Gaps = 42/350 (12%)

Query: 1999 DVLQLLRILYIVASDPYSRISQEDGDEQLQFTFPPDEFTSKKITTKILQQIEEPLALASG 2058
            DV+ LLR+L+ ++   Y         E +    P  EF + K+T K  +Q+++PL + +G
Sbjct: 1470 DVILLLRVLHAISRYWYYLYDNAMCKEII----PTSEFINSKLTAKANRQLQDPLVIMTG 1525

Query: 2059 ALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRD 2118
             +P W  +L   CPF  PF+TRQ+ F  TAF   RA+  L +          T   + + 
Sbjct: 1526 NIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLD----------TNPEINQS 1575

Query: 2119 DPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFY 2178
            D  + RV      + +    E L++ AE+VMQ     +++LE+++  E GTGLGPTLEFY
Sbjct: 1576 DSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFY 1635

Query: 2179 ALVAAEFQRTDLGAWLCDDNFPDDESRHVDLGG--GLKPPGYYVQRSCGLFTAPFPQDSD 2236
            ALV+ E QR DLG W             V L    G +    Y+Q   GLF  PF + + 
Sbjct: 1636 ALVSQELQRADLGLW---------RGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAK 1686

Query: 2237 --ELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMC----------MGDIKSNMS 2284
               + ++   F FLG  +AK I D RLVDLP+  PF+K M           + DI   ++
Sbjct: 1687 PAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVA 1746

Query: 2285 KLIYE----SRGDRDLHCTESQSEASTEEGHDSLSV-GSFEEDSKSEFIL 2329
            + +Y      R  + L   +SQ++ S +   ++L++ G   ED   +F L
Sbjct: 1747 RSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTL 1796



 Score = 65.9 bits (159), Expect = 5e-10
 Identities = 55/208 (26%), Positives = 95/208 (45%), Gaps = 20/208 (9%)

Query: 13  LQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDESAPDNVLE 72
           LQ  Q  +   QL A+ ++C LL+M +  +      P ++ +PAL  +   E   D ++ 
Sbjct: 443 LQGLQASDESQQLQAVIEMCQLLVMGN--EETLGGFPVKSVVPALITLLQMEHNFD-IMN 499

Query: 73  VTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELICT 132
              RA+TY ++     +  +V    AI     +L V++       D+AEQ +  LE++  
Sbjct: 500 HACRALTYMMEALPRSSAVVVD---AIPVFLEKLQVIQCI-----DVAEQALTALEMLSR 551

Query: 133 RESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLS 192
           R S A+ +AGGL   L ++         +   +A+A+ +  C  + P +       +SL 
Sbjct: 552 RHSKAILQAGGLADCLLYL----EFFSINAQRNALAIAANCCQSITPDE--FHFVADSLP 605

Query: 193 SL---LKHEDHQVSDGALRCFASLADRF 217
            L   L H+D +  +    CFA L D F
Sbjct: 606 LLTQRLTHQDKKSVESTCLCFARLVDNF 633



 Score = 52.4 bits (124), Expect = 6e-06
 Identities = 40/154 (25%), Positives = 77/154 (50%), Gaps = 20/154 (12%)

Query: 903  ENTISPYEMCSSGLVQALLTVLNNSMDLDMKQDCSQLVERINVFKTAFSENEDDESR--- 959
            E+ +S +E+  SG V+ LL  L +  + D      +L   ++VF ++    E+   R   
Sbjct: 1150 ESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPIGRVEP 1209

Query: 960  ----PAVALIRKLIAVLESIERLPLHLYDTP-----GSTYNLQ--------ILTRRLRFR 1002
                P +AL+ K+   L  +E+ P+ ++D P     G +++L           T +L+ +
Sbjct: 1210 VGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKFFNTHQLKCQ 1269

Query: 1003 LERAPGETALIDRTGRMLKMEPLATVESLEQYLL 1036
            L+R P    +    G  +K++PLA V+++E+YL+
Sbjct: 1270 LQRHPDCANVKQWKGGPVKIDPLALVQAIERYLV 1303



 Score = 49.3 bits (116), Expect = 5e-05
 Identities = 38/146 (26%), Positives = 67/146 (45%), Gaps = 10/146 (6%)

Query: 488 PVNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSIRKASLAL 547
           P+   +     ++ KD+      K DPE+A  ++K L  V  + +  +  P++R   L  
Sbjct: 802 PLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRA 861

Query: 548 IRKMIHFCSEALLKEVCDSD-VGHNLPTILVEITATVLDQEDDDDGHLLALQIIRDLVDK 606
           I ++I+F    LLK+V  +  V  ++ ++L      ++         + ALQ+   L+ K
Sbjct: 862 ILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIV---------VGALQMAEILMQK 912

Query: 607 GGDIFLDQLARLGVISKVSTLAGPSS 632
             DIF     R GV+ +V  LA   S
Sbjct: 913 LPDIFSVYFRREGVMHQVKHLAESES 938



 Score = 40.8 bits (94), Expect = 0.018
 Identities = 65/286 (22%), Positives = 117/286 (40%), Gaps = 30/286 (10%)

Query: 1344 ASPKPVSSTVSGTTQSWSSLV---KNNCPDKTSAA----AGSSSRKGSSSSVCSVASSSD 1396
            A  +P   ++ G + S SS V   +   PD+ + +     G   +K +S  V   ++S D
Sbjct: 21   AGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSRGV-KRSASPD 79

Query: 1397 ISLGSTKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTL-TAET 1455
             +  ++ +  +    ++H+  S ++ ++P           + ++ S+ S STS   T ++
Sbjct: 80   YNRTNSPSSAKKPKALQHT-ESPSETNKPHSKSKKRHLDQEQQLKSAQSPSTSKAHTRKS 138

Query: 1456 GSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNR 1515
            G+    R     S  R   ESS +  G          S SE T  E  S +P   ++ + 
Sbjct: 139  GATGGSR-----SQKRKRTESSCVKSG----------SGSESTGAEERSAKPTKLASKSA 183

Query: 1516 LSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSDNNT 1575
             S  +  +     SS+AS  + SS   +S  S V   A + +    N    SRS+S  + 
Sbjct: 184  TSAKAGCSTITDSSSAAS-TSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSP 242

Query: 1576 NTLGRNVMSTATSPL----MGAQSFPNLTTPGTTSTVTMSTSSVTS 1617
                R    + T         A+  P ++ P T  ++  S+ S TS
Sbjct: 243  RRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETS 288



 Score = 32.0 bits (71), Expect = 8.2
 Identities = 52/219 (23%), Positives = 87/219 (39%), Gaps = 38/219 (17%)

Query: 1372 TSAAAG------SSSRKGSSSSVCSVASSSDI-------------------SLGSTKTER 1406
            TSA AG      SSS   +SSS  +VAS+S                        S+ + R
Sbjct: 184  TSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSPR 243

Query: 1407 RSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAE----R 1462
            RS    E S   G+   +     S   ++P+T++    S+ + T         A+    R
Sbjct: 244  RSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLASLR 303

Query: 1463 KLGPDSSVRTPGESSAI-------SMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNR 1515
            K     S   P E  ++       + G  + +S   S + +    EA  Q  ++   SN+
Sbjct: 304  KSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPESNQ 363

Query: 1516 LSVSSLLAA--GAPMSSSASVPNLSSRETSSLESFVRRV 1552
             +V+S  A    AP  ++ +V   +S E+ S +S + R+
Sbjct: 364  EAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRL 402


>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
            protein ligase 1 [Homo sapiens]
          Length = 909

 Score =  119 bits (299), Expect = 3e-26
 Identities = 85/258 (32%), Positives = 126/258 (48%), Gaps = 21/258 (8%)

Query: 2350 ELVNPHRAR-FLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSGPPLSIEDL 2408
            +LVN +  R F K I  + +  + + S      D +  K  + +L N         I DL
Sbjct: 656  QLVNIYFTRSFYKHILGIPVNYQDVASI-----DPEYAKNLQWILDN--------DISDL 702

Query: 2409 GLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRD 2467
            GL   F   + ++G    V LKP G   ++T +N  EYV L+ +  M   IQ Q+ AF  
Sbjct: 703  GLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQ 762

Query: 2468 GFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVL 2527
            GF+   P   +  F   E++++L G   P     D I  TE   GY R+ P    F  V+
Sbjct: 763  GFHMFIPPSLIQLFDEYELELLLSG--MPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVV 820

Query: 2528 CGMSSDERKAFLQFTTGCSTLPPGGLANLHP----RLTVVRKVDATDASYPSVNTCVHYL 2583
              ++ +ER   LQF TG S +P GG AN+      +   +  V  T    P+ +TC++ L
Sbjct: 821  EDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINML 880

Query: 2584 KLPEYSSEEIMRERLLAA 2601
            KLPEY S+EI+++RLL A
Sbjct: 881  KLPEYPSKEILKDRLLVA 898



 Score = 52.0 bits (123), Expect = 8e-06
 Identities = 34/94 (36%), Positives = 52/94 (55%), Gaps = 3/94 (3%)

Query: 388 EVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVNRGQRSSS--LHYAACFGRPQVAKT 445
           +V+  D +GQT L+ A   G +  V+ L + GAD+NR   S +  L++A   G+   A+ 
Sbjct: 156 DVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQI 215

Query: 446 LLRHGANPDLRDEDGKTPLDKARERGHSEVVAIL 479
           LL  GA   L D++G TPLD   + G+ E   +L
Sbjct: 216 LLLRGAK-YLPDKNGVTPLDLCVQGGYGETCEVL 248



 Score = 48.5 bits (114), Expect = 8e-05
 Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 2/96 (2%)

Query: 390 NFMDDVGQTLLNWASAFGTQEMVEFLCERGADVN--RGQRSSSLHYAACFGRPQVAKTLL 447
           N+ D  G T L+ A+  G ++ +  L E  ADVN    +  +++H+ A  GR ++   L+
Sbjct: 92  NYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLV 151

Query: 448 RHGANPDLRDEDGKTPLDKARERGHSEVVAILQSPG 483
           +H ++ D+ D  G+T L  A + GH   V  L   G
Sbjct: 152 QHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSG 187



 Score = 40.4 bits (93), Expect = 0.023
 Identities = 29/107 (27%), Positives = 47/107 (43%), Gaps = 2/107 (1%)

Query: 388 EVNFMDDVGQTLLNWASAFGTQEMVEFLCERGADVN--RGQRSSSLHYAACFGRPQVAKT 445
           +VN  ++ G T ++W +  G  E++  L +  +DV+       ++LH A   G     + 
Sbjct: 123 DVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQC 182

Query: 446 LLRHGANPDLRDEDGKTPLDKARERGHSEVVAILQSPGDWMCPVNKG 492
           LL  GA+ +  +  G TPL  A   G  +   IL   G    P   G
Sbjct: 183 LLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNG 229



 Score = 37.7 bits (86), Expect = 0.15
 Identities = 28/85 (32%), Positives = 39/85 (45%), Gaps = 3/85 (3%)

Query: 398 TLLNWASAFGTQEMVEFLCERGADVNRG---QRSSSLHYAACFGRPQVAKTLLRHGANPD 454
           TL+    A   + + E L     DVN      + S LH AA  G  +    LL+ GANP+
Sbjct: 33  TLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPN 92

Query: 455 LRDEDGKTPLDKARERGHSEVVAIL 479
            +D  G TPL  A   G  + ++ L
Sbjct: 93  YQDISGCTPLHLAARNGQKKCMSKL 117


>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
          Length = 872

 Score =  115 bits (289), Expect = 4e-25
 Identities = 71/204 (34%), Positives = 113/204 (55%), Gaps = 7/204 (3%)

Query: 2406 EDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAF 2465
            +D+ + FQ   +         DLK +G+   IT +N +E+V+L  D+ ++  ++KQ +AF
Sbjct: 671  DDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAF 730

Query: 2466 RDGFNKVFPMEKLS-SFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFV 2524
            R GF+ V     L   F  EE+++++CG+++  + A  +   TE   GYTRDS     F 
Sbjct: 731  RRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQA--LEETTEYDGGYTRDSVLIREFW 788

Query: 2525 RVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLK 2584
             ++   + ++++ FLQFTTG    P GGL  L     ++ K        P+ +TC + L 
Sbjct: 789  EIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDTERLPTSHTCFNVLL 845

Query: 2585 LPEYSSEEIMRERLL-AATMEKGF 2607
            LPEYSS+E ++ERLL A T  KGF
Sbjct: 846  LPEYSSKEKLKERLLKAITYAKGF 869



 Score = 33.9 bits (76), Expect = 2.2
 Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 2132 RVKVPRG----ESLMEWAENVMQIHADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQ 2186
            R+KV R     ++L+      M+  AD K  L VEF GE+G    G + EF+ LV  E  
Sbjct: 521  RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIF 580

Query: 2187 RTDLGAWLCDDN 2198
              D+G +  D++
Sbjct: 581  NPDIGMFTYDES 592


>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
          Length = 852

 Score =  115 bits (289), Expect = 4e-25
 Identities = 71/204 (34%), Positives = 113/204 (55%), Gaps = 7/204 (3%)

Query: 2406 EDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAF 2465
            +D+ + FQ   +         DLK +G+   IT +N +E+V+L  D+ ++  ++KQ +AF
Sbjct: 651  DDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAF 710

Query: 2466 RDGFNKVFPMEKLS-SFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFV 2524
            R GF+ V     L   F  EE+++++CG+++  + A  +   TE   GYTRDS     F 
Sbjct: 711  RRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQA--LEETTEYDGGYTRDSVLIREFW 768

Query: 2525 RVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLK 2584
             ++   + ++++ FLQFTTG    P GGL  L     ++ K        P+ +TC + L 
Sbjct: 769  EIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDTERLPTSHTCFNVLL 825

Query: 2585 LPEYSSEEIMRERLL-AATMEKGF 2607
            LPEYSS+E ++ERLL A T  KGF
Sbjct: 826  LPEYSSKEKLKERLLKAITYAKGF 849



 Score = 33.9 bits (76), Expect = 2.2
 Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 2132 RVKVPRG----ESLMEWAENVMQIHADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQ 2186
            R+KV R     ++L+      M+  AD K  L VEF GE+G    G + EF+ LV  E  
Sbjct: 501  RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIF 560

Query: 2187 RTDLGAWLCDDN 2198
              D+G +  D++
Sbjct: 561  NPDIGMFTYDES 572


>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
          Length = 875

 Score =  115 bits (289), Expect = 4e-25
 Identities = 71/204 (34%), Positives = 113/204 (55%), Gaps = 7/204 (3%)

Query: 2406 EDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAF 2465
            +D+ + FQ   +         DLK +G+   IT +N +E+V+L  D+ ++  ++KQ +AF
Sbjct: 674  DDMMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAF 733

Query: 2466 RDGFNKVFPMEKLS-SFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFV 2524
            R GF+ V     L   F  EE+++++CG+++  + A  +   TE   GYTRDS     F 
Sbjct: 734  RRGFHMVTNESPLKYLFRPEEIELLICGSRNLDFQA--LEETTEYDGGYTRDSVLIREFW 791

Query: 2525 RVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLK 2584
             ++   + ++++ FLQFTTG    P GGL  L     ++ K        P+ +TC + L 
Sbjct: 792  EIVHSFTDEQKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDTERLPTSHTCFNVLL 848

Query: 2585 LPEYSSEEIMRERLL-AATMEKGF 2607
            LPEYSS+E ++ERLL A T  KGF
Sbjct: 849  LPEYSSKEKLKERLLKAITYAKGF 872



 Score = 33.9 bits (76), Expect = 2.2
 Identities = 25/72 (34%), Positives = 37/72 (51%), Gaps = 5/72 (6%)

Query: 2132 RVKVPRG----ESLMEWAENVMQIHADRKSVLEVEFLGEEGTGL-GPTLEFYALVAAEFQ 2186
            R+KV R     ++L+      M+  AD K  L VEF GE+G    G + EF+ LV  E  
Sbjct: 524  RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIF 583

Query: 2187 RTDLGAWLCDDN 2198
              D+G +  D++
Sbjct: 584  NPDIGMFTYDES 595


>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
            isoform 2 [Homo sapiens]
          Length = 431

 Score =  113 bits (282), Expect = 3e-24
 Identities = 76/213 (35%), Positives = 112/213 (52%), Gaps = 16/213 (7%)

Query: 2404 SIEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQM 2462
            ++E+ GL   F     I G  T  +LK  GE   +T +N EEY+ L+ D+    G+++Q 
Sbjct: 223  NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQT 282

Query: 2463 EAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQS---PSWAAEDIINYTEPKLGYTRDSPG 2519
            +AF DGFN+V P+E L  F  +E++++LCG Q      W    I  +      YT++S  
Sbjct: 283  KAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH------YTKNSKQ 336

Query: 2520 FLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANL----HPRLTVVRKVDATDASYPS 2575
               F +V+  M +++R   LQF TG   LP GG A L     P+   + KV   +   P 
Sbjct: 337  IQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKV-GKETWLPR 395

Query: 2576 VNTCVHYLKLPEYSSEEIMRERLLAATME-KGF 2607
             +TC + L LP Y S E +RE+LL A  E +GF
Sbjct: 396  SHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 428


>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
            isoform 1 [Homo sapiens]
          Length = 870

 Score =  113 bits (282), Expect = 3e-24
 Identities = 76/213 (35%), Positives = 112/213 (52%), Gaps = 16/213 (7%)

Query: 2404 SIEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQM 2462
            ++E+ GL   F     I G  T  +LK  GE   +T +N EEY+ L+ D+    G+++Q 
Sbjct: 662  NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQT 721

Query: 2463 EAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQS---PSWAAEDIINYTEPKLGYTRDSPG 2519
            +AF DGFN+V P+E L  F  +E++++LCG Q      W    I  +      YT++S  
Sbjct: 722  KAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH------YTKNSKQ 775

Query: 2520 FLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANL----HPRLTVVRKVDATDASYPS 2575
               F +V+  M +++R   LQF TG   LP GG A L     P+   + KV   +   P 
Sbjct: 776  IQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKV-GKETWLPR 834

Query: 2576 VNTCVHYLKLPEYSSEEIMRERLLAATME-KGF 2607
             +TC + L LP Y S E +RE+LL A  E +GF
Sbjct: 835  SHTCFNRLDLPPYKSYEQLREKLLYAIEETEGF 867


>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
            sapiens]
          Length = 922

 Score =  112 bits (281), Expect = 4e-24
 Identities = 74/213 (34%), Positives = 112/213 (52%), Gaps = 16/213 (7%)

Query: 2404 SIEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQM 2462
            +IE+ GL   F     I G  T+ DLK  G + ++T +N +EY+ LM ++    G+Q+Q 
Sbjct: 714  NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQT 773

Query: 2463 EAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQS---PSWAAEDIINYTEPKLGYTRDSPG 2519
            +AF DGFN+V P++ L  F  +E++++LCG Q      W    +  +      YTR+S  
Sbjct: 774  KAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH------YTRNSKQ 827

Query: 2520 FLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANL----HPRLTVVRKVDATDASYPS 2575
             + F + +    ++ R   LQF TG   LP GG A L     P+   + KV   D   P 
Sbjct: 828  IIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKV-GKDTWLPR 886

Query: 2576 VNTCVHYLKLPEYSSEEIMRERLLAATME-KGF 2607
             +TC + L LP Y S E ++E+LL A  E +GF
Sbjct: 887  SHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919


>gi|222352183 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 650  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 709

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 710  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 767

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 768  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 826

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 827  LPPYETFEDLREKLLMA 843


>gi|21361472 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 3 [Homo sapiens]
          Length = 955

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 751  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 810

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 811  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 868

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 869  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 927

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 928  LPPYETFEDLREKLLMA 944


>gi|222352094 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 630  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 689

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 690  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 747

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 748  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 806

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 807  LPPYETFEDLREKLLMA 823


>gi|222352092 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 6 [Homo sapiens]
          Length = 834

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 630  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 689

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 690  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 747

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 748  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 806

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 807  LPPYETFEDLREKLLMA 823


>gi|222352090 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 5 [Homo sapiens]
          Length = 947

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 743  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 802

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 803  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 860

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 861  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 919

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 920  LPPYETFEDLREKLLMA 936


>gi|222352088 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 4 [Homo sapiens]
          Length = 967

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 763  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 822

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 823  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 880

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 881  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 939

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 940  LPPYETFEDLREKLLMA 956


>gi|222352086 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 1 [Homo sapiens]
          Length = 975

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 771  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 830

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 831  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 888

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 889  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 947

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 948  LPPYETFEDLREKLLMA 964


>gi|222352084 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 650  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 709

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 710  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 767

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 768  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 826

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 827  LPPYETFEDLREKLLMA 843


>gi|222352082 neural precursor cell expressed, developmentally
            down-regulated 4-like isoform 2 [Homo sapiens]
          Length = 854

 Score =  107 bits (268), Expect = 1e-22
 Identities = 64/197 (32%), Positives = 105/197 (53%), Gaps = 8/197 (4%)

Query: 2410 LNFQFCPSSRIYGFT-AVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G T  VDLKP+G + M+T +N  EY+DL+  +     +QKQM AF +G
Sbjct: 650  LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEG 709

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P++ +  F   E+++++CG         D   ++  K GY  + P    F + + 
Sbjct: 710  FTELLPIDLIKIFDENELELLMCGLGDVD--VNDWRQHSIYKNGYCPNHPVIQWFWKAVL 767

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M +++R   LQF TG S +P  G A L+    P+L  + +  + +   P  +TC + L 
Sbjct: 768  LMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPE-KLPRAHTCFNRLD 826

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP Y + E +RE+LL A
Sbjct: 827  LPPYETFEDLREKLLMA 843


>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
          Length = 1083

 Score =  106 bits (265), Expect = 3e-22
 Identities = 67/207 (32%), Positives = 111/207 (53%), Gaps = 4/207 (1%)

Query: 2405 IEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEA 2464
            +E+LGLNF    ++ +     V+LK  G+D  +T  N   Y+ L+ D+ ++  I++   A
Sbjct: 880  VEELGLNFTVV-NNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLA 938

Query: 2465 FRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFV 2524
            FR G   V  +E L  F  +E+Q+++ G Q P  + ED+ ++T    GY+ D P    F 
Sbjct: 939  FRQGLANVVSLEWLRMFDQQEIQVLISGAQVPI-SLEDLKSFTNYSGGYSADHPVIKVFW 997

Query: 2525 RVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLK 2584
            RV+ G + +E++  L+F T CS  P  G   L+P    +    +     P+ +TC++ LK
Sbjct: 998  RVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAF-CIHNGGSDLERLPTASTCMNLLK 1056

Query: 2585 LPEYSSEEIMRERLL-AATMEKGFHLN 2610
            LPE+  E ++R +LL A     GF L+
Sbjct: 1057 LPEFYDETLLRSKLLYAIECAAGFELS 1083


>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
          Length = 862

 Score =  105 bits (261), Expect = 8e-22
 Identities = 68/213 (31%), Positives = 113/213 (53%), Gaps = 16/213 (7%)

Query: 2404 SIEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQM 2462
            +IE+  L   F     I G   + DLKP+G + ++T +N EEY+ ++ ++ +  G+++Q 
Sbjct: 654  NIEECDLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQT 713

Query: 2463 EAFRDGFNKVFPMEKLSSFSHEEVQMILCGNQS---PSWAAEDIINYTEPKLGYTRDSPG 2519
            +AF +GFN++ P + L  F  +E++++LCG Q      W    I  +      Y R S  
Sbjct: 714  QAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH------YARTSKQ 767

Query: 2520 FLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANL----HPRLTVVRKVDATDASYPS 2575
             + F + +  + +++R   LQF TG   LP GG A+L     P+   + KV   +   P 
Sbjct: 768  IMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKV-GKENWLPR 826

Query: 2576 VNTCVHYLKLPEYSSEEIMRERLLAATME-KGF 2607
             +TC + L LP Y S E ++E+LL A  E +GF
Sbjct: 827  SHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 859


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score = 98.2 bits (243), Expect = 9e-20
 Identities = 69/212 (32%), Positives = 108/212 (50%), Gaps = 10/212 (4%)

Query: 2405 IEDLGLNFQFCPSSRIYGFTAV-DLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQME 2463
            +  LG +  F    + +G   V DLKP+G + ++T +N +EYV L+    M   I+KQ+ 
Sbjct: 4165 VSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLA 4224

Query: 2464 AFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRF 2523
            AF +GF ++ P   +S F+ +E+++++ G   P+   +D+ + TE    Y  +S     F
Sbjct: 4225 AFLEGFYEIIPKRLISIFTEQELELLISG--LPTIDIDDLKSNTEYH-KYQSNSIQIQWF 4281

Query: 2524 VRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTV----VRKVDATDASYPSVNTC 2579
             R L      +R  FLQF TG S +P  G A L     +    + + D +    PS +TC
Sbjct: 4282 WRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTC 4341

Query: 2580 VHYLKLPEYSSEEIMRERLLAATME--KGFHL 2609
             + L LP Y S E +R  LL A  E  +GF L
Sbjct: 4342 FNQLDLPAYESFEKLRHMLLLAIQECSEGFGL 4373



 Score = 38.9 bits (89), Expect = 0.067
 Identities = 50/207 (24%), Positives = 91/207 (43%), Gaps = 18/207 (8%)

Query: 1448 TSTLTAETGSENAERKLGPDSSVRTPGESSAISMGIVS-----VSSPDVSSVSELTNKEA 1502
            T   T ET  E+ +R+ G  +   +P  S + S GI +     +   D  +VS    K +
Sbjct: 3352 TQQRTKETNCES-DRERG--NKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSR-KGKNS 3407

Query: 1503 ASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNATN 1562
                P+S+      S  SL A+      +     +  R +   E  +R ++ I+     N
Sbjct: 3408 VKSVPVSAGGEGETSPYSLEASPLGQLMNMLSHPVIRRSSLLTEKLLRLLSLISIALPEN 3467

Query: 1563 NMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTPGTTSTVTMSTSSVTSSSNVA 1622
             ++ ++++S +     G +  +TATS      S    T   TT T   + + VTS+  + 
Sbjct: 3468 KVSEAQANSGS-----GASSTTTATS----TTSTTTTTAASTTPTPPTAPTPVTSAPALV 3518

Query: 1623 TATTVLSVGQSLSNTLTTSLTSTSSES 1649
             AT + ++  + S T+TT  T+T++ S
Sbjct: 3519 AATAISTIVVAASTTVTTPTTATTTVS 3545



 Score = 35.4 bits (80), Expect = 0.74
 Identities = 13/28 (46%), Positives = 23/28 (82%)

Query: 1676 DDDEDLPEPDEEDDENEDDNQEDQEYEE 1703
            +D++D  + +EE++E+E+D+QED E EE
Sbjct: 2426 EDEDDSQDEEEEEEEDEEDDQEDDEGEE 2453



 Score = 33.9 bits (76), Expect = 2.2
 Identities = 56/279 (20%), Positives = 102/279 (36%), Gaps = 60/279 (21%)

Query: 1424 EPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAERKLGPDSSVRTPGESSAISMGI 1483
            +P+  LS   N P +  GS S++S +   +E  ++ A +     S+ + PGE      G 
Sbjct: 2248 KPLETLSRIVNQPSSLFGSKSASSKNK--SEQDAQGASQD--SSSNQQDPGEP-----GE 2298

Query: 1484 VSVSSPDVSSVSELTNKEAASQRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETS 1543
              V   D     ++T  E A    +   A       S++ AG P   S+    + +    
Sbjct: 2299 AEVQEED----HDVTQTEVADGDIMDGEAET----DSVVIAGQPEVLSSQEMQVENELED 2350

Query: 1544 SLESFVRRVANIARTNATNNMNLSRSSSDNNTNTLGRNVMSTATSPLMGAQSFPNLTTPG 1603
             ++  + R       +  + + +SRS  D +   +   +M  A S L  A          
Sbjct: 2351 LIDELLERDGG----SGNSTIIVSRSGEDESQEDV---LMDEAPSNLSQAS--------- 2394

Query: 1604 TTSTVTMSTSSVTSSSNVATATTVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFL 1663
                        T  +N   +  +L       +T     + ++ + D  Q+ E       
Sbjct: 2395 ------------TLQANREDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEE----- 2437

Query: 1664 DSCRASTLLAELDDDEDLPEPDEEDDENEDDNQEDQEYE 1702
                      E +D+ED  E DE ++ +EDD+ +  E E
Sbjct: 2438 ----------EEEDEEDDQEDDEGEEGDEDDDDDGSEME 2466



 Score = 32.3 bits (72), Expect = 6.3
 Identities = 19/71 (26%), Positives = 38/71 (53%), Gaps = 2/71 (2%)

Query: 1633 SLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDDEDLPEPDEEDDENE 1692
            S ++TL  +   + +  D   E E++  +  DS  ++    +  D+E+  E DEEDD+ +
Sbjct: 2391 SQASTLQANREDSMNILDPEDEEEHTQEE--DSSGSNEDEDDSQDEEEEEEEDEEDDQED 2448

Query: 1693 DDNQEDQEYEE 1703
            D+ +E  E ++
Sbjct: 2449 DEGEEGDEDDD 2459


>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
            sapiens]
          Length = 748

 Score = 92.8 bits (229), Expect = 4e-18
 Identities = 61/203 (30%), Positives = 95/203 (46%), Gaps = 14/203 (6%)

Query: 2410 LNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     YG     +LKP+G+   +  +N +EYV L  ++    GI+ Q  A + G
Sbjct: 545  LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKG 604

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCG---NQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVR 2525
            FN+V P   L +F  +E+++I+CG        W     + +  P      DS     F +
Sbjct: 605  FNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTP------DSNIVKWFWK 658

Query: 2526 VLCGMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVH 2581
             +     + R   LQF TG S +P  G   L     PRL  + ++DA   + P  +TC +
Sbjct: 659  AVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFN 718

Query: 2582 YLKLPEYSSEEIMRERLLAATME 2604
             + +P Y S E + E+LL A  E
Sbjct: 719  RIDIPPYESYEKLYEKLLTAIEE 741


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 91.3 bits (225), Expect = 1e-17
 Identities = 51/117 (43%), Positives = 65/117 (55%), Gaps = 10/117 (8%)

Query: 1229 LSLSGFELYGTVNGVCEDQLGKAAKEAEANLRRQRRLVRSQV---------LKYMVPGAR 1279
            L+ +   L G      E+ +  +A+ A A +  + R   + V            M  G R
Sbjct: 1813 LTQTALRLIGPSCDNVEEDMNASAQGASATVLEETRKETAPVQLPVSGPELAAMMKIGTR 1872

Query: 1280 VIRGLDWKWRDQDGSPQGEGTVTGEL-HNGWIDVTWDAGGSNSYRMGAEGKFDLKLA 1335
            V+RG+DWKW DQDG P G G V GEL  +GWI V WD G +NSYRMG EGK+DLKLA
Sbjct: 1873 VMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLA 1929



 Score = 73.9 bits (180), Expect = 2e-12
 Identities = 53/176 (30%), Positives = 88/176 (50%), Gaps = 10/176 (5%)

Query: 2427 DLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEV 2486
            D++ S +   IT+DN  EYV L  ++ +H    +Q+ A R+G  +V P+  LS F+  E+
Sbjct: 4612 DIQLSSKHTHITLDNRAEYVRLAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYEL 4670

Query: 2487 QMILCGNQS-PSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGC 2545
            + ++CG+   P    + +  Y     G    +     F  V+   S+ ER  FL+F  G 
Sbjct: 4671 ETMVCGSPDIPLHLLKSVATYK----GIEPSASLIQWFWEVMESFSNTERSLFLRFVWGR 4726

Query: 2546 STLPPGGLANLHPR---LTVVRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERL 2598
            + LP   +A+   R   + V+ K +  D   P   TC   LKLP YS ++++ E+L
Sbjct: 4727 TRLPRT-IADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKL 4781


>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
          Length = 776

 Score = 89.4 bits (220), Expect = 4e-17
 Identities = 59/184 (32%), Positives = 95/184 (51%), Gaps = 7/184 (3%)

Query: 2427 DLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEV 2486
            +LKP G+   +T  N +EYV L  DF ++  I KQ  AF  GF+ V     L     EEV
Sbjct: 598  NLKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEV 657

Query: 2487 QMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCS 2546
            ++++CG  SP      +   T+   GY +       F  V+ G   D +K  L FTTG  
Sbjct: 658  EILVCG--SPDLDMHALQRSTQYD-GYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSD 714

Query: 2547 TLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLKLPEYSSEEIMRERL-LAATMEK 2605
             +P GG+A+L+ +++   K + +    P  +TC + L LP Y S++ ++++L +  +  +
Sbjct: 715  RVPVGGMADLNFKIS---KNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSE 771

Query: 2606 GFHL 2609
            GF L
Sbjct: 772  GFGL 775


>gi|114520609 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 1 [Homo sapiens]
          Length = 900

 Score = 89.0 bits (219), Expect = 6e-17
 Identities = 61/204 (29%), Positives = 102/204 (50%), Gaps = 9/204 (4%)

Query: 2410 LNFQFCPSSRIYGFTAV-DLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+ +F     ++G T   +LK  G + ++T  N +EY+ L+  +     IQKQM AF++G
Sbjct: 696  LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEG 755

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P + +  F   E+++++CG         D   +T+ K GY+ +      F + + 
Sbjct: 756  FFELIPQDLIKIFDENELELLMCGLGDVD--VNDWREHTKYKNGYSANHQVIQWFWKAVL 813

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M S++R   LQF TG S +P  G A L+    P+   V +   T    P  +TC + L 
Sbjct: 814  MMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQW-GTPEKLPRAHTCFNRLD 872

Query: 2585 LPEYSS-EEIMRERLLAATMEKGF 2607
            LP Y S EE+  +  +A    +GF
Sbjct: 873  LPPYESFEELWDKLQMAIENTQGF 896


>gi|114520607 neural precursor cell expressed, developmentally
            down-regulated 4 isoform 2 [Homo sapiens]
          Length = 1247

 Score = 89.0 bits (219), Expect = 6e-17
 Identities = 61/204 (29%), Positives = 102/204 (50%), Gaps = 9/204 (4%)

Query: 2410 LNFQFCPSSRIYGFTAV-DLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+ +F     ++G T   +LK  G + ++T  N +EY+ L+  +     IQKQM AF++G
Sbjct: 1043 LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEG 1102

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFVRVLC 2528
            F ++ P + +  F   E+++++CG         D   +T+ K GY+ +      F + + 
Sbjct: 1103 FFELIPQDLIKIFDENELELLMCGLGDVD--VNDWREHTKYKNGYSANHQVIQWFWKAVL 1160

Query: 2529 GMSSDERKAFLQFTTGCSTLPPGGLANLH----PRLTVVRKVDATDASYPSVNTCVHYLK 2584
             M S++R   LQF TG S +P  G A L+    P+   V +   T    P  +TC + L 
Sbjct: 1161 MMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQW-GTPEKLPRAHTCFNRLD 1219

Query: 2585 LPEYSS-EEIMRERLLAATMEKGF 2607
            LP Y S EE+  +  +A    +GF
Sbjct: 1220 LPPYESFEELWDKLQMAIENTQGF 1243


>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
            sapiens]
          Length = 757

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 17/206 (8%)

Query: 2410 LNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G     +LKP+G +  +T +N +EYV L  ++    GI+ Q  A + G
Sbjct: 551  LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKG 610

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQS---PSWAAEDIINYTEPKLGYTRDSPGFLRFVR 2525
            FN++ P   L  F  +E+++I+ G        W +   + +         DS     F +
Sbjct: 611  FNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHC------VADSNIVRWFWQ 664

Query: 2526 VLCGMSSDERKAFLQFTTGCSTLPPGGLANLH-------PRLTVVRKVDATDASYPSVNT 2578
             +     + R   LQF TG + +P  G   L        PRL  +  +DA   + P  +T
Sbjct: 665  AVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHT 724

Query: 2579 CVHYLKLPEYSSEEIMRERLLAATME 2604
            C + + +P Y S E + E+LL A  E
Sbjct: 725  CFNRIDIPPYESYEKLYEKLLTAVEE 750


>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
            sapiens]
          Length = 731

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 57/206 (27%), Positives = 93/206 (45%), Gaps = 17/206 (8%)

Query: 2410 LNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEAFRDG 2468
            L+  FC     +G     +LKP+G +  +T +N +EYV L  ++    GI+ Q  A + G
Sbjct: 525  LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKG 584

Query: 2469 FNKVFPMEKLSSFSHEEVQMILCGNQS---PSWAAEDIINYTEPKLGYTRDSPGFLRFVR 2525
            FN++ P   L  F  +E+++I+ G        W +   + +         DS     F +
Sbjct: 585  FNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHC------VADSNIVRWFWQ 638

Query: 2526 VLCGMSSDERKAFLQFTTGCSTLPPGGLANLH-------PRLTVVRKVDATDASYPSVNT 2578
             +     + R   LQF TG + +P  G   L        PRL  +  +DA   + P  +T
Sbjct: 639  AVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHT 698

Query: 2579 CVHYLKLPEYSSEEIMRERLLAATME 2604
            C + + +P Y S E + E+LL A  E
Sbjct: 699  CFNRIDIPPYESYEKLYEKLLTAVEE 724


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score = 83.2 bits (204), Expect = 3e-15
 Identities = 58/197 (29%), Positives = 92/197 (46%), Gaps = 8/197 (4%)

Query: 2406 EDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEA 2464
            E   LNF  C  S  YG      L P G++  +  DN +E+VD   ++     + +   A
Sbjct: 851  ETFCLNFTICRES--YGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTA 908

Query: 2465 FRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRFV 2524
            F  GF KV   + L  F   E++ ++ GN + +W  E++      K  Y+   P    F 
Sbjct: 909  FSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNW--EELEETAIYKGDYSATHPTVKLFW 966

Query: 2525 RVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATDASYPSVNTCVHYLK 2584
                    +++K FL F TG   +P  G+A+L     V++   + +   P  +TC + L 
Sbjct: 967  ETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQ---IVIQSTASGEEYLPVAHTCYNLLD 1023

Query: 2585 LPEYSSEEIMRERLLAA 2601
            LP+YSS+EI+  RL  A
Sbjct: 1024 LPKYSSKEILSARLTQA 1040


>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
          Length = 1068

 Score = 82.4 bits (202), Expect = 5e-15
 Identities = 68/233 (29%), Positives = 103/233 (44%), Gaps = 31/233 (13%)

Query: 2405 IEDLGLNFQFCPSSRIYG-FTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQME 2463
            I DLGL   +     + G     +L P G+   +T +N   Y+ LM  F MHT I+ Q  
Sbjct: 840  ITDLGLTLSY--DEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTA 897

Query: 2464 AFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRF 2523
            A   GF  +   E +  FS  E+Q ++ G+ +     ED+  +T    G+       +  
Sbjct: 898  ALISGFRSIIKPEWIRMFSTPELQRLISGDNA-EIDLEDLKKHTVYYGGFHGSHRVIIWL 956

Query: 2524 VRVLCG-MSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRKVDATD------------ 2570
              +L    + DER  FL+F T CS  P  G A L P  + +R V+ +D            
Sbjct: 957  WDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFS-IRCVEVSDDQDTGDTLGSVL 1015

Query: 2571 ------------ASYPSVNTCVHYLKLPEYSSEEIMRERL-LAATMEKGFHLN 2610
                           P+ +TC + LKLP YS + ++RE+L  A +M  GF L+
Sbjct: 1016 RGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,799,411
Number of Sequences: 37866
Number of extensions: 4893954
Number of successful extensions: 33697
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 354
Number of HSP's successfully gapped in prelim test: 422
Number of HSP's that attempted gapping in prelim test: 23949
Number of HSP's gapped (non-prelim): 6372
length of query: 2610
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2491
effective length of database: 13,741,464
effective search space: 34229986824
effective search space used: 34229986824
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.