BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] (1614 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 3232 0.0 gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 3230 0.0 gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 3227 0.0 gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 93 2e-18 gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 93 2e-18 gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 82 4e-15 gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 82 4e-15 gi|54607135 translocase of outer mitochondrial membrane 70 homol... 77 1e-13 gi|118766328 transmembrane and tetratricopeptide repeat containi... 71 7e-12 gi|118766330 transmembrane and tetratricopeptide repeat containi... 71 7e-12 gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 70 2e-11 gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ... 69 4e-11 gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 65 5e-10 gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 62 3e-09 gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H... 61 8e-09 gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 60 2e-08 gi|83415184 transmembrane and tetratricopeptide repeat containin... 60 2e-08 gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H... 59 4e-08 gi|224809432 transmembrane and tetratricopeptide repeat containi... 59 5e-08 gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens] 55 4e-07 gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 55 5e-07 gi|22749211 transmembrane and tetratricopeptide repeat containin... 55 5e-07 gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 55 5e-07 gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap... 54 2e-06 gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 53 3e-06 gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-... 52 5e-06 gi|225735595 RNA polymerase II associated protein 3 isoform 3 [H... 52 6e-06 gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens] 48 7e-05 gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens] 47 1e-04 gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 47 2e-04 >gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 3232 bits (8380), Expect = 0.0 Identities = 1614/1614 (100%), Positives = 1614/1614 (100%) Query: 1 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA Sbjct: 1 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60 Query: 61 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF Sbjct: 61 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120 Query: 121 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH Sbjct: 121 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180 Query: 181 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR Sbjct: 181 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240 Query: 241 EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300 EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI Sbjct: 241 EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300 Query: 301 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM Sbjct: 301 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360 Query: 361 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA Sbjct: 361 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420 Query: 421 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE Sbjct: 421 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480 Query: 481 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH Sbjct: 481 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540 Query: 541 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET Sbjct: 541 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600 Query: 601 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL Sbjct: 601 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660 Query: 661 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES Sbjct: 661 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720 Query: 721 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS Sbjct: 721 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780 Query: 781 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR Sbjct: 781 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840 Query: 841 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES Sbjct: 841 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900 Query: 901 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI Sbjct: 901 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960 Query: 961 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD Sbjct: 961 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020 Query: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN Sbjct: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 Query: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV Sbjct: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140 Query: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN Sbjct: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200 Query: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL 1260 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL Sbjct: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL 1260 Query: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF Sbjct: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320 Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440 Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500 Query: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY Sbjct: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560 Query: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI Sbjct: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 >gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo sapiens] Length = 1614 Score = 3230 bits (8375), Expect = 0.0 Identities = 1613/1614 (99%), Positives = 1613/1614 (99%) Query: 1 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA Sbjct: 1 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60 Query: 61 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF Sbjct: 61 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120 Query: 121 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH Sbjct: 121 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180 Query: 181 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR Sbjct: 181 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240 Query: 241 EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300 EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI Sbjct: 241 EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300 Query: 301 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM Sbjct: 301 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360 Query: 361 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA Sbjct: 361 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420 Query: 421 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE Sbjct: 421 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480 Query: 481 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH Sbjct: 481 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540 Query: 541 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET Sbjct: 541 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600 Query: 601 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL Sbjct: 601 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660 Query: 661 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES Sbjct: 661 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720 Query: 721 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS Sbjct: 721 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780 Query: 781 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR Sbjct: 781 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840 Query: 841 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES Sbjct: 841 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900 Query: 901 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI Sbjct: 901 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960 Query: 961 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD Sbjct: 961 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020 Query: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN Sbjct: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 Query: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV Sbjct: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140 Query: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN Sbjct: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200 Query: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL 1260 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSY AFYNRALCYTKIRELQMALTDYGIVL Sbjct: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVL 1260 Query: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF Sbjct: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320 Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440 Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500 Query: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY Sbjct: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560 Query: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI Sbjct: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 >gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 3227 bits (8367), Expect = 0.0 Identities = 1611/1614 (99%), Positives = 1612/1614 (99%) Query: 1 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA Sbjct: 1 MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60 Query: 61 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF Sbjct: 61 RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120 Query: 121 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH Sbjct: 121 YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180 Query: 181 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR Sbjct: 181 LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240 Query: 241 EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300 EAAGLGAQGEQ+SWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI Sbjct: 241 EAAGLGAQGEQDSWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300 Query: 301 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM Sbjct: 301 RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360 Query: 361 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA Sbjct: 361 SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420 Query: 421 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE Sbjct: 421 KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480 Query: 481 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH Sbjct: 481 LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540 Query: 541 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET Sbjct: 541 IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600 Query: 601 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL Sbjct: 601 LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660 Query: 661 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES Sbjct: 661 RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720 Query: 721 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS Sbjct: 721 IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780 Query: 781 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR Sbjct: 781 KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840 Query: 841 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES Sbjct: 841 TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900 Query: 901 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI Sbjct: 901 EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960 Query: 961 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD Sbjct: 961 YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020 Query: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN Sbjct: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 Query: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV Sbjct: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140 Query: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDA SHSDKGPDAT ISADCLYN Sbjct: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDASSHSDKGPDATTISADCLYN 1200 Query: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL 1260 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL Sbjct: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL 1260 Query: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF Sbjct: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320 Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440 Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500 Query: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY Sbjct: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560 Query: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI Sbjct: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 >gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] Length = 1036 Score = 93.2 bits (230), Expect = 2e-18 Identities = 82/302 (27%), Positives = 128/302 (42%), Gaps = 18/302 (5%) Query: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373 H + + + +F T A+K NP +AY GN Y E G ++A + + AL + P Sbjct: 55 HFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQ---LQEAIEHYRHALRLKPD 111 Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433 +I I+ L A G + A + A+ +P Y V +GN A+ + Sbjct: 112 FIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY-------CVRSDLGNLLKALGRLE 164 Query: 1434 AA-----MKISTTAEFL---TNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNI 1485 A I T F +N G + G A+ ++ A+TL+P + AY N GN+ Sbjct: 165 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 224 Query: 1486 YFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAA 1545 R F +A + +AL P + V N A + A + + IE P + Sbjct: 225 LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284 Query: 1546 VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQAL 1605 Y N A+ AE+ N AL L P A N A ++ + G IEEA+ Y +AL Sbjct: 285 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 344 Query: 1606 DL 1607 ++ Sbjct: 345 EV 346 Score = 76.6 bits (187), Expect = 2e-13 Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 27/291 (9%) Query: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIV 1259 NLG + +G + LAI A+++D N A+ N + R A+ Y Sbjct: 186 NLGCVFNAQGEIW----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 241 Query: 1260 LLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRIN 1318 L L V N +Y E G A++ +++A L + C+ + Sbjct: 242 LSLSPNHAVVHG---NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK-G 297 Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378 EA + + AL++ P D+ N E G+ E +A + + KAL + P + A Sbjct: 298 SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIE---EAVRLYRKALEVFPEFAAAH 354 Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438 + LQ QGK Q+A H+ AI P AY MGN MQD+ A++ Sbjct: 355 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN-------MGNTLKEMQDVQGALQC 407 Query: 1439 STTA--------EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFN 1481 T A + +N IH+ G+ A+ Y+ A+ L P + AY N Sbjct: 408 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCN 458 Score = 74.7 bits (182), Expect = 7e-13 Identities = 67/286 (23%), Positives = 129/286 (45%), Gaps = 9/286 (3%) Query: 1225 AISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284 AI N +A+ N + E+ +A+ + + LD L+ ++N G + E Sbjct: 173 AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF---LDAYINLGNVLKEAR 229 Query: 1285 QYGFALEDFKQAALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVG 1343 + A+ + +A +S N ++ H C ++ + A++ + A+++ P F DAY Sbjct: 230 IFDRAVAAYLRALSLS-PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 288 Query: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAID 1403 N+ E G + +A+ + AL + P + + + + QG ++A + A++ Sbjct: 289 LANALKEKG---SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345 Query: 1404 TDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAM 1462 P+ A+ A V Q G A+ A++IS T A+ +N G + M Q A+ Sbjct: 346 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405 Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPE 1508 + Y AI +NP ++ A+ N +I+ +A + ALK P+ Sbjct: 406 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451 Score = 72.8 bits (177), Expect = 3e-12 Identities = 96/394 (24%), Positives = 152/394 (38%), Gaps = 61/394 (15%) Query: 1264 ATETVKLNTFL-----NRGLIYVELGQYGFALEDFKQAALISRT--NGSLCHATAMCHHR 1316 +T +K N L N G +Y E GQ A+E ++ A + +G + A A+ Sbjct: 68 STLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALV--A 125 Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK 1376 + E AV + AL+ NP GN G E K +LKA+ P + Sbjct: 126 AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPNFAV 182 Query: 1377 ARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAM 1436 A + G AQG+ A +HF A+ DP AY + +GN + + A+ Sbjct: 183 AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY-------INLGNVLKEARIFDRAV 235 Query: 1437 KISTTAEFLT-NRGVIHEFMG---HKQN----AMKDYQDAITLNPKYSLAYFNAGNIYFH 1488 A L+ N V+H + ++Q A+ Y+ AI L P + AY N N Sbjct: 236 AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 295 Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548 ++A D ++ AL+ P + L N A EEA + +E P +AA + Sbjct: 296 KGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHS 355 Query: 1549 NRA--------------HFYYCLK--------------------QYELAEEDLNKALSLK 1574 N A H+ ++ + A + +A+ + Sbjct: 356 NLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQIN 415 Query: 1575 PNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 P A ++ A + G I EA+A Y AL L+ Sbjct: 416 PAFADAHSNLASIHKDSGNIPEAIASYRTALKLK 449 Score = 57.0 bits (136), Expect = 1e-07 Identities = 91/426 (21%), Positives = 155/426 (36%), Gaps = 49/426 (11%) Query: 917 AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976 A AY G +Y++ G+LQ A+ + + L+P F++ Y + + + A+ Sbjct: 79 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 138 Query: 977 IHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV- 1035 +YN + + + + A Y +AI++ P A + G ++ ++ Sbjct: 139 ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 198 Query: 1036 LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLM 1095 LAI F K + DP DA + G E + A+ + L++ ++ G L Sbjct: 199 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGN--LA 256 Query: 1096 MKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCA 1155 YY +Q LI + + +AIE+ C Sbjct: 257 CVYY-----------------------EQGLIDLAIDTYRRAIELQP-----HFPDAYCN 288 Query: 1156 LLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215 L ++ K EA + AL AD L NL E+GN++ Sbjct: 289 LANALKEKGS-VAEAEDCYNTAL----------RLCPTHADSLNNLANIKREQGNIEEAV 337 Query: 1216 KLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275 +L A+ + A N A + +LQ AL Y + + T + + N Sbjct: 338 RL----YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA---DAYSN 390 Query: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335 G E+ AL+ + +A I+ A H EA+ + ALK+ P Sbjct: 391 MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450 Query: 1336 CFLDAY 1341 F DAY Sbjct: 451 DFPDAY 456 Score = 36.2 bits (82), Expect = 0.26 Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 8/152 (5%) Query: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985 I R+ G ++ A+ ++ + + P F A+ + + Q K+ EAL + + Sbjct: 326 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385 Query: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV-LAIDDFSKC 1044 +AY + + +D+ A+ YT+AI+ P AD + +++ + + AI + Sbjct: 386 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445 Query: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFT 1076 + P DA YC + + D+T Sbjct: 446 LKLKPDFPDA-------YCNLAHCLQIVCDWT 470 >gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] Length = 1046 Score = 93.2 bits (230), Expect = 2e-18 Identities = 82/302 (27%), Positives = 128/302 (42%), Gaps = 18/302 (5%) Query: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373 H + + + +F T A+K NP +AY GN Y E G ++A + + AL + P Sbjct: 65 HFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQ---LQEAIEHYRHALRLKPD 121 Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433 +I I+ L A G + A + A+ +P Y V +GN A+ + Sbjct: 122 FIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY-------CVRSDLGNLLKALGRLE 174 Query: 1434 AA-----MKISTTAEFL---TNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNI 1485 A I T F +N G + G A+ ++ A+TL+P + AY N GN+ Sbjct: 175 EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 234 Query: 1486 YFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAA 1545 R F +A + +AL P + V N A + A + + IE P + Sbjct: 235 LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 294 Query: 1546 VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQAL 1605 Y N A+ AE+ N AL L P A N A ++ + G IEEA+ Y +AL Sbjct: 295 AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 354 Query: 1606 DL 1607 ++ Sbjct: 355 EV 356 Score = 76.6 bits (187), Expect = 2e-13 Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 27/291 (9%) Query: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIV 1259 NLG + +G + LAI A+++D N A+ N + R A+ Y Sbjct: 196 NLGCVFNAQGEIW----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 251 Query: 1260 LLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRIN 1318 L L V N +Y E G A++ +++A L + C+ + Sbjct: 252 LSLSPNHAVVHG---NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK-G 307 Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378 EA + + AL++ P D+ N E G+ E +A + + KAL + P + A Sbjct: 308 SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIE---EAVRLYRKALEVFPEFAAAH 364 Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438 + LQ QGK Q+A H+ AI P AY MGN MQD+ A++ Sbjct: 365 SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN-------MGNTLKEMQDVQGALQC 417 Query: 1439 STTA--------EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFN 1481 T A + +N IH+ G+ A+ Y+ A+ L P + AY N Sbjct: 418 YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCN 468 Score = 74.7 bits (182), Expect = 7e-13 Identities = 67/286 (23%), Positives = 129/286 (45%), Gaps = 9/286 (3%) Query: 1225 AISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284 AI N +A+ N + E+ +A+ + + LD L+ ++N G + E Sbjct: 183 AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF---LDAYINLGNVLKEAR 239 Query: 1285 QYGFALEDFKQAALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVG 1343 + A+ + +A +S N ++ H C ++ + A++ + A+++ P F DAY Sbjct: 240 IFDRAVAAYLRALSLS-PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 298 Query: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAID 1403 N+ E G + +A+ + AL + P + + + + QG ++A + A++ Sbjct: 299 LANALKEKG---SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 355 Query: 1404 TDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAM 1462 P+ A+ A V Q G A+ A++IS T A+ +N G + M Q A+ Sbjct: 356 VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 415 Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPE 1508 + Y AI +NP ++ A+ N +I+ +A + ALK P+ Sbjct: 416 QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461 Score = 72.8 bits (177), Expect = 3e-12 Identities = 96/394 (24%), Positives = 152/394 (38%), Gaps = 61/394 (15%) Query: 1264 ATETVKLNTFL-----NRGLIYVELGQYGFALEDFKQAALISRT--NGSLCHATAMCHHR 1316 +T +K N L N G +Y E GQ A+E ++ A + +G + A A+ Sbjct: 78 STLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALV--A 135 Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK 1376 + E AV + AL+ NP GN G E K +LKA+ P + Sbjct: 136 AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPNFAV 192 Query: 1377 ARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAM 1436 A + G AQG+ A +HF A+ DP AY + +GN + + A+ Sbjct: 193 AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY-------INLGNVLKEARIFDRAV 245 Query: 1437 KISTTAEFLT-NRGVIHEFMG---HKQN----AMKDYQDAITLNPKYSLAYFNAGNIYFH 1488 A L+ N V+H + ++Q A+ Y+ AI L P + AY N N Sbjct: 246 AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 305 Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548 ++A D ++ AL+ P + L N A EEA + +E P +AA + Sbjct: 306 KGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHS 365 Query: 1549 NRA--------------HFYYCLK--------------------QYELAEEDLNKALSLK 1574 N A H+ ++ + A + +A+ + Sbjct: 366 NLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQIN 425 Query: 1575 PNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 P A ++ A + G I EA+A Y AL L+ Sbjct: 426 PAFADAHSNLASIHKDSGNIPEAIASYRTALKLK 459 Score = 57.0 bits (136), Expect = 1e-07 Identities = 91/426 (21%), Positives = 155/426 (36%), Gaps = 49/426 (11%) Query: 917 AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976 A AY G +Y++ G+LQ A+ + + L+P F++ Y + + + A+ Sbjct: 89 AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 148 Query: 977 IHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV- 1035 +YN + + + + A Y +AI++ P A + G ++ ++ Sbjct: 149 ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 208 Query: 1036 LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLM 1095 LAI F K + DP DA + G E + A+ + L++ ++ G L Sbjct: 209 LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGN--LA 266 Query: 1096 MKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCA 1155 YY +Q LI + + +AIE+ C Sbjct: 267 CVYY-----------------------EQGLIDLAIDTYRRAIELQP-----HFPDAYCN 298 Query: 1156 LLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215 L ++ K EA + AL AD L NL E+GN++ Sbjct: 299 LANALKEKGS-VAEAEDCYNTAL----------RLCPTHADSLNNLANIKREQGNIEEAV 347 Query: 1216 KLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275 +L A+ + A N A + +LQ AL Y + + T + + N Sbjct: 348 RL----YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA---DAYSN 400 Query: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335 G E+ AL+ + +A I+ A H EA+ + ALK+ P Sbjct: 401 MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 460 Query: 1336 CFLDAY 1341 F DAY Sbjct: 461 DFPDAY 466 Score = 36.2 bits (82), Expect = 0.26 Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 8/152 (5%) Query: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985 I R+ G ++ A+ ++ + + P F A+ + + Q K+ EAL + + Sbjct: 336 IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 395 Query: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV-LAIDDFSKC 1044 +AY + + +D+ A+ YT+AI+ P AD + +++ + + AI + Sbjct: 396 DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455 Query: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFT 1076 + P DA YC + + D+T Sbjct: 456 LKLKPDFPDA-------YCNLAHCLQIVCDWT 480 >gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapiens] Length = 830 Score = 82.0 bits (201), Expect = 4e-15 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 8/194 (4%) Query: 1423 GNNFAAMQDINAAMKISTTA-EFLTNRGVIHEFMGHK-------QNAMKDYQDAITLNPK 1474 GN F+ ++ + A+K A + N + +GH+ A+ +++AI +NP+ Sbjct: 580 GNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPR 639 Query: 1475 YSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534 + A++ G IY+ +FS A +F KAL +P++ +L + + LKK E+A + Sbjct: 640 HYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLN 699 Query: 1535 NVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594 I P F+RA + ++Y+ A ++L + + P ++LVY KV K+G Sbjct: 700 KAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 759 Query: 1595 EEAMADYNQALDLE 1608 A+ +++ A+DL+ Sbjct: 760 HLALMNFSWAMDLD 773 Score = 65.5 bits (158), Expect = 4e-10 Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 4/221 (1%) Query: 1309 ATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKAL 1368 A C E + A+ FF A++++P + AY G+ E+ E +A F A+ Sbjct: 578 AAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGH---EFVLTEELDKALACFRNAI 634 Query: 1369 HINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAA 1428 +NP + A G Q KF A HF A+D +P++ + VV + + A Sbjct: 635 RVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 694 Query: 1429 MQDINAAMKISTTAEFLTNRGVIHEFMGHK-QNAMKDYQDAITLNPKYSLAYFNAGNIYF 1487 + +N A+ I F K ++A+++ ++ + PK SL YF G +Y Sbjct: 695 LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYK 754 Query: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEE 1528 Q A FS A+ DP+ + AI L EE Sbjct: 755 KLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEE 795 Score = 59.7 bits (143), Expect = 2e-08 Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 51/315 (16%) Query: 1275 NRGLIYVELGQYGFALEDFKQAALIS---------RTNGSLCHATAMCHHRINEFEEAVN 1325 N G + ++G+ F L ++ QA I R G ++T + H + + ++ Sbjct: 503 NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLS 562 Query: 1326 F-FTWALKINPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383 T K +P +A+ GN + ++ HD A K F +A+ ++P Y A G+ Sbjct: 563 KDLTDMDKNSP---EAWCAAGNCFSLQREHDIAIKF----FQRAIQVDPNYAYAYTLLGH 615 Query: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAE 1443 + KA F AI +P++Y A+ G Sbjct: 616 EFVLTEELDKALACFRNAIRVNPRHYNAWYGL---------------------------- 647 Query: 1444 FLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKAL 1503 G+I+ A +Q A+ +NP+ S+ + G + ++ +A D +KA+ Sbjct: 648 -----GMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 702 Query: 1504 KFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA 1563 DP+N +RA +KY+ A ++ + + P + VYF Y L Q LA Sbjct: 703 VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLA 762 Query: 1564 EEDLNKALSLKPNDA 1578 + + A+ L P A Sbjct: 763 LMNFSWAMDLDPKGA 777 Score = 52.4 bits (124), Expect = 4e-06 Identities = 43/199 (21%), Positives = 86/199 (43%), Gaps = 4/199 (2%) Query: 902 VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961 + +L++++ D K A+C G + + A+ QR I ++P + AY + Sbjct: 558 LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 617 Query: 962 LFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADI 1021 + +++++AL + N + A+ IY ++ +LA +++ +A+ P + + Sbjct: 618 VLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 677 Query: 1022 YFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 G + K A+D +K I DPK R NE + +A+++ L Sbjct: 678 LCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQ 737 Query: 1081 IDHQNSQARGQYLLMMKYY 1099 I + S Y L+ K Y Sbjct: 738 IVPKESLV---YFLIGKVY 753 Score = 49.7 bits (117), Expect = 2e-05 Identities = 38/152 (25%), Positives = 67/152 (44%), Gaps = 10/152 (6%) Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522 KD D +P+ A+ AGN + R+ A +F +A++ DP Y + Sbjct: 563 KDLTDMDKNSPE---AWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 619 Query: 1523 LKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582 ++ ++A F N I P ++ YY +++ LAE KAL + P +++ Sbjct: 620 TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL- 678 Query: 1583 FRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 IG+++ A+ +ALD + A VI Sbjct: 679 ------CHIGVVQHALKKSEKALDTLNKAIVI 704 Score = 42.0 bits (97), Expect = 0.005 Identities = 28/128 (21%), Positives = 55/128 (42%), Gaps = 4/128 (3%) Query: 897 YYESEVKILTE----EINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLN 952 YY+ E L E + D + C G + L K + A++ L + I+++P Sbjct: 651 YYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 710 Query: 953 AYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAI 1012 +HR + +K AL +L + + + Y ++Y+ LA++N++ A+ Sbjct: 711 CKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAM 770 Query: 1013 KSTPTDAD 1020 P A+ Sbjct: 771 DLDPKGAN 778 Score = 39.3 bits (90), Expect = 0.031 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 21/194 (10%) Query: 907 EEINDKTKYPAFAY------CRRGAIYRKLGKLQSAMNDLQRVILLE-------PLFLNA 953 E IN + P+ Y C+ G Y +L + A V +E ++ Sbjct: 489 EAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT 548 Query: 954 YWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIK 1013 WH +++ L D++ KN+ EA+ + + +++ +AI + +AI+ Sbjct: 549 LWHLQKDVALS-VLSKDLTDMD------KNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQ 601 Query: 1014 STPTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAI 1072 P A Y G + +T ++ A+ F I +P+ +A G+ Y + E + A Sbjct: 602 VDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAE 661 Query: 1073 EDFTALLNIDHQNS 1086 F L+I+ Q+S Sbjct: 662 MHFQKALDINPQSS 675 >gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapiens] Length = 824 Score = 82.0 bits (201), Expect = 4e-15 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 8/194 (4%) Query: 1423 GNNFAAMQDINAAMKISTTA-EFLTNRGVIHEFMGHK-------QNAMKDYQDAITLNPK 1474 GN F+ ++ + A+K A + N + +GH+ A+ +++AI +NP+ Sbjct: 574 GNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPR 633 Query: 1475 YSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534 + A++ G IY+ +FS A +F KAL +P++ +L + + LKK E+A + Sbjct: 634 HYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLN 693 Query: 1535 NVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594 I P F+RA + ++Y+ A ++L + + P ++LVY KV K+G Sbjct: 694 KAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 753 Query: 1595 EEAMADYNQALDLE 1608 A+ +++ A+DL+ Sbjct: 754 HLALMNFSWAMDLD 767 Score = 65.5 bits (158), Expect = 4e-10 Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 4/221 (1%) Query: 1309 ATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKAL 1368 A C E + A+ FF A++++P + AY G+ E+ E +A F A+ Sbjct: 572 AAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGH---EFVLTEELDKALACFRNAI 628 Query: 1369 HINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAA 1428 +NP + A G Q KF A HF A+D +P++ + VV + + A Sbjct: 629 RVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 688 Query: 1429 MQDINAAMKISTTAEFLTNRGVIHEFMGHK-QNAMKDYQDAITLNPKYSLAYFNAGNIYF 1487 + +N A+ I F K ++A+++ ++ + PK SL YF G +Y Sbjct: 689 LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYK 748 Query: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEE 1528 Q A FS A+ DP+ + AI L EE Sbjct: 749 KLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEE 789 Score = 59.7 bits (143), Expect = 2e-08 Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 51/315 (16%) Query: 1275 NRGLIYVELGQYGFALEDFKQAALIS---------RTNGSLCHATAMCHHRINEFEEAVN 1325 N G + ++G+ F L ++ QA I R G ++T + H + + ++ Sbjct: 497 NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLS 556 Query: 1326 F-FTWALKINPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383 T K +P +A+ GN + ++ HD A K F +A+ ++P Y A G+ Sbjct: 557 KDLTDMDKNSP---EAWCAAGNCFSLQREHDIAIKF----FQRAIQVDPNYAYAYTLLGH 609 Query: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAE 1443 + KA F AI +P++Y A+ G Sbjct: 610 EFVLTEELDKALACFRNAIRVNPRHYNAWYGL---------------------------- 641 Query: 1444 FLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKAL 1503 G+I+ A +Q A+ +NP+ S+ + G + ++ +A D +KA+ Sbjct: 642 -----GMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696 Query: 1504 KFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA 1563 DP+N +RA +KY+ A ++ + + P + VYF Y L Q LA Sbjct: 697 VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLA 756 Query: 1564 EEDLNKALSLKPNDA 1578 + + A+ L P A Sbjct: 757 LMNFSWAMDLDPKGA 771 Score = 52.4 bits (124), Expect = 4e-06 Identities = 43/199 (21%), Positives = 86/199 (43%), Gaps = 4/199 (2%) Query: 902 VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961 + +L++++ D K A+C G + + A+ QR I ++P + AY + Sbjct: 552 LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 611 Query: 962 LFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADI 1021 + +++++AL + N + A+ IY ++ +LA +++ +A+ P + + Sbjct: 612 VLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 671 Query: 1022 YFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080 G + K A+D +K I DPK R NE + +A+++ L Sbjct: 672 LCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQ 731 Query: 1081 IDHQNSQARGQYLLMMKYY 1099 I + S Y L+ K Y Sbjct: 732 IVPKESLV---YFLIGKVY 747 Score = 49.7 bits (117), Expect = 2e-05 Identities = 38/152 (25%), Positives = 67/152 (44%), Gaps = 10/152 (6%) Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522 KD D +P+ A+ AGN + R+ A +F +A++ DP Y + Sbjct: 557 KDLTDMDKNSPE---AWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613 Query: 1523 LKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582 ++ ++A F N I P ++ YY +++ LAE KAL + P +++ Sbjct: 614 TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL- 672 Query: 1583 FRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614 IG+++ A+ +ALD + A VI Sbjct: 673 ------CHIGVVQHALKKSEKALDTLNKAIVI 698 Score = 42.0 bits (97), Expect = 0.005 Identities = 28/128 (21%), Positives = 55/128 (42%), Gaps = 4/128 (3%) Query: 897 YYESEVKILTE----EINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLN 952 YY+ E L E + D + C G + L K + A++ L + I+++P Sbjct: 645 YYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 704 Query: 953 AYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAI 1012 +HR + +K AL +L + + + Y ++Y+ LA++N++ A+ Sbjct: 705 CKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAM 764 Query: 1013 KSTPTDAD 1020 P A+ Sbjct: 765 DLDPKGAN 772 Score = 39.3 bits (90), Expect = 0.031 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 21/194 (10%) Query: 907 EEINDKTKYPAFAY------CRRGAIYRKLGKLQSAMNDLQRVILLE-------PLFLNA 953 E IN + P+ Y C+ G Y +L + A V +E ++ Sbjct: 483 EAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT 542 Query: 954 YWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIK 1013 WH +++ L D++ KN+ EA+ + + +++ +AI + +AI+ Sbjct: 543 LWHLQKDVALS-VLSKDLTDMD------KNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQ 595 Query: 1014 STPTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAI 1072 P A Y G + +T ++ A+ F I +P+ +A G+ Y + E + A Sbjct: 596 VDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAE 655 Query: 1073 EDFTALLNIDHQNS 1086 F L+I+ Q+S Sbjct: 656 MHFQKALDINPQSS 669 >gi|54607135 translocase of outer mitochondrial membrane 70 homolog A [Homo sapiens] Length = 608 Score = 77.4 bits (189), Expect = 1e-13 Identities = 111/493 (22%), Positives = 190/493 (38%), Gaps = 76/493 (15%) Query: 1004 AILNYTQAIKSTPTDADI-----YFRRGEMYEITNKVLAI-DDFSKCIFYDPKRTDALLK 1057 AI YT+AI PT+ ++ Y R +E K + D +K + +PK AL + Sbjct: 133 AIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 192 Query: 1058 RGLFYCENENWFAAIEDFTALLNID---HQNSQARGQYLLMMKYYDLAKFTIYQIAEMDK 1114 R + + +N +ED TA+ ++ +Q S +L + + AK E K Sbjct: 193 RAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAK-------EKYK 245 Query: 1115 GLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVL 1174 L P Q + F D ++++ +K +++ E Sbjct: 246 NREPLMPSPQFIKSYFSSFTDD-------------------IISQPMLKGEKSDE----- 281 Query: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMD-KNSY 1233 DK +A + + Y YMEE N Y I++ + I + K Sbjct: 282 --------DKDKEGEALEVKENSGYLKAKQYMEEEN----YDKIISECSKEIDAEGKYMA 329 Query: 1234 IAFYNRALCYTKIRELQMALTDYG-IVLLLDATETVKLNTFLNRGLIYVELGQYGFALED 1292 A RA Y I A D ++ L +A ++ N + RG +Y++ Q + +D Sbjct: 330 EALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQD 389 Query: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP---------CFL---DA 1340 F AA I N + H +++ EEAV F +++ P CF A Sbjct: 390 FNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQA 449 Query: 1341 YVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTI 1400 Y G +S ++ A K F + + P + + L Q +F KA + Sbjct: 450 YTGNNSSQIQ--------AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDK 501 Query: 1401 AIDTDPKNYLAYEGRAVVCLQMGNNF-AAMQDINAAMKISTTAEF-LTNRGVIHEFMGHK 1458 ID +P N Y + ++ LQ + ++ I+ A++I +F G I G+ Sbjct: 502 CIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNM 561 Query: 1459 QNAMKDYQDAITL 1471 + A+ + AI L Sbjct: 562 EKAIDMFNKAINL 574 Score = 51.6 bits (122), Expect = 6e-06 Identities = 73/327 (22%), Positives = 130/327 (39%), Gaps = 53/327 (16%) Query: 1314 HHRINEFEEAVNFFTWALKINPCF--LDAYVGRGNSYMEYGHDEATKQAQKDFLKALHIN 1371 + + ++E+A+ +T A+ + P +D N + + K+ +D KA+ +N Sbjct: 124 YFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELN 183 Query: 1372 PAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQD 1431 P Y+KA F++A H + D K + AV L+ N +M Sbjct: 184 PKYVKAL------------FRRAKAHEKL----DNKKECLEDVTAVCILEGFQNQQSMLL 227 Query: 1432 INAAMKI---STTAEFLTNR-------------------GVIHEFM--GHKQNAMKDYQD 1467 + +K+ E NR +I + M G K + KD ++ Sbjct: 228 ADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKD-KE 286 Query: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYV---LMNRAITNTILK 1524 L K + Y A Y + + SK + D E +Y+ L+ RA ++ Sbjct: 287 GEALEVKENSGYLKAKQ-YMEEENYDKIISECSKEI--DAEGKYMAEALLLRATFYLLIG 343 Query: 1525 KYEEAKEDFANVIE----SCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580 AK D VI + A R Y +Q L+ +D N A + P +A V Sbjct: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403 Query: 1581 YNFRAKVRGKIGLIEEAMADYNQALDL 1607 Y+ R +++ + +EEA+AD+++ + L Sbjct: 404 YHHRGQLKILLDQVEEAVADFDECIRL 430 Score = 48.5 bits (114), Expect = 5e-05 Identities = 51/225 (22%), Positives = 94/225 (41%), Gaps = 20/225 (8%) Query: 1371 NPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG--RAVVCLQMGNNFAA 1428 N Y+KA+ + + K + + ID + K Y+A RA L +GN AA Sbjct: 295 NSGYLKAK-----QYMEEENYDKIISECSKEIDAEGK-YMAEALLLRATFYLLIGNANAA 348 Query: 1429 MQDINAAMKISTT-----AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAG 1483 D++ + + A L RG ++ + +D+ A ++P+ + Y + G Sbjct: 349 KPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRG 408 Query: 1484 NIYFHHRQFSQASDYFSKALKFDPENE-------YVLMNRAITNTILKKYEEAKEDFANV 1536 + Q +A F + ++ PE+ + L +A T + + A + F V Sbjct: 409 QLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEV 468 Query: 1537 IESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581 I+ P A Y A +Q+ A+E +K + L+P++A Y Sbjct: 469 IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTY 513 Score = 40.8 bits (94), Expect = 0.011 Identities = 49/244 (20%), Positives = 92/244 (37%), Gaps = 27/244 (11%) Query: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973 K A A +RG++Y + + + D ++P + Y HR + + D++ EA+ D Sbjct: 364 KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423 Query: 974 LNYIHKYNKNNTEAYLSKA-EIYR------GKKDITLAILNYTQAIKSTPTDADIYFRRG 1026 + + + A K +YR I A+ + + IK P A+ Y Sbjct: 424 FDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYA 483 Query: 1027 EMYEITNKVLAIDD-FSKCIFYDPKRTDALLKRGLFYCE-NENWFAAIEDFTALLNIDHQ 1084 + + D+ + KCI +P + +GL + ++ +E + + ID++ Sbjct: 484 QALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNK 543 Query: 1085 NSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSEL--------SPMQQALIYSFCENHDK 1136 A Y+ Q M+K + S M+ A +YS C+ Sbjct: 544 CDFA----------YETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHA 593 Query: 1137 AIEV 1140 EV Sbjct: 594 QTEV 597 Score = 40.4 bits (93), Expect = 0.014 Identities = 38/192 (19%), Positives = 75/192 (39%), Gaps = 15/192 (7%) Query: 1339 DAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR----ISFGYNLQAQGKFQKA 1394 +A + R Y+ G+ A K D K + + A +K R I G Q + + Sbjct: 330 EALLLRATFYLLIGNANAAKP---DLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLS 386 Query: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEF--------LT 1446 F +A D DP+N Y R + + + A+ D + +++ + L Sbjct: 387 TQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALY 446 Query: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506 + Q AMK +++ I P+ + Y +QF +A + + K + + Sbjct: 447 RQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506 Query: 1507 PENEYVLMNRAI 1518 P+N +++ + Sbjct: 507 PDNATTYVHKGL 518 Score = 38.1 bits (87), Expect = 0.069 Identities = 83/403 (20%), Positives = 149/403 (36%), Gaps = 58/403 (14%) Query: 1262 LDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHAT-----AMCHHR 1316 LD + N+G Y + G+Y A++ + +A + T ++ +T A + Sbjct: 106 LDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQ 165 Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGH-----DEATK-------QAQKDF 1364 + +++E T A+++NP ++ A R ++ + + ++ T Q Q+ Sbjct: 166 LQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSM 225 Query: 1365 LKALHINPAYIKARISFGYN----LQAQGKFQKAW-NHFTIAIDTDPK-------NYLAY 1412 L A + K + Y L +F K++ + FT I + P Sbjct: 226 LLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDK 285 Query: 1413 EGRAVVCLQMGNNFAAMQ----------------DINAAMKISTTAEFLTNRGVIHEFMG 1456 EG A+ + A Q +I+A K AE L R + +G Sbjct: 286 EGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYM--AEALLLRATFYLLIG 343 Query: 1457 HKQNAMKDYQDAITLNPKYSLAYFNA----GNIYFHHRQFSQASDYFSKALKFDPENEYV 1512 + A D I+L NA G++Y +Q ++ F+ A DP+N V Sbjct: 344 NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403 Query: 1513 LMNRAITNTILKKYEEAKEDFANVIESCPFWAA-------VYFNRAHFYYCLKQYELAEE 1565 +R +L + EEA DF I P A + +A+ Q + A + Sbjct: 404 YHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMK 463 Query: 1566 DLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 + + P A Y A+ +A Y++ +DLE Sbjct: 464 GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506 Score = 37.0 bits (84), Expect = 0.15 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 5/91 (5%) Query: 1525 KYEEAKEDFANVIESCPFWAAV-----YFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579 KYE+A + + I CP V Y NRA + L++++ +D KA+ L P Sbjct: 129 KYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVK 188 Query: 1580 VYNFRAKVRGKIGLIEEAMADYNQALDLEDY 1610 RAK K+ +E + D LE + Sbjct: 189 ALFRRAKAHEKLDNKKECLEDVTAVCILEGF 219 Score = 32.3 bits (72), Expect = 3.8 Identities = 23/100 (23%), Positives = 44/100 (44%), Gaps = 5/100 (5%) Query: 879 KLKLNDYVESDLPQEVIKYYESEVKILTEEIN-DKTKYPAFAYCRRGAIYRKLGKLQSAM 937 K K N Y ++ ++ I+ Y + + E N D + + Y R A + +L K + Sbjct: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTF----YQNRAAAFEQLQKWKEVA 173 Query: 938 NDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYI 977 D + + L P ++ A + R + D E L+D+ + Sbjct: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAV 213 >gi|118766328 transmembrane and tetratricopeptide repeat containing 4 isoform 2 [Homo sapiens] Length = 741 Score = 71.2 bits (173), Expect = 7e-12 Identities = 66/294 (22%), Positives = 130/294 (44%), Gaps = 4/294 (1%) Query: 1304 GSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKD 1363 G L T C R E+ F AL + P + G + + G+ A A + Sbjct: 448 GILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTA---AIRY 504 Query: 1364 FLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423 + +A+ +NP Y+ A + G L+ + + Q+A ++A+ P A+ +V + Sbjct: 505 YREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLK 564 Query: 1424 NNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482 AA Q A+K + N G ++ + +A+ +++A L P++SLA+ N Sbjct: 565 RFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624 Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542 + + +QA +AL+ P + ++ + A +KY+E++ F I++ P Sbjct: 625 IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684 Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEE 1596 A+ + N A Y+ +LA++ +L L P + +R K+ L+++ Sbjct: 685 AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738 Score = 70.1 bits (170), Expect = 2e-11 Identities = 43/152 (28%), Positives = 73/152 (48%) Query: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMN 1515 G++ A++ Y++A+ LNPKY A N GNI + +A + S A++ P+ MN Sbjct: 496 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555 Query: 1516 RAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP 1575 I LK++E A++ + I+ + Y+N Y L ++ A A LKP Sbjct: 556 LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKP 615 Query: 1576 NDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607 +L +N + G + +A A +AL+L Sbjct: 616 EHSLAWNNMIILLDNTGNLAQAEAVGREALEL 647 >gi|118766330 transmembrane and tetratricopeptide repeat containing 4 isoform 1 [Homo sapiens] Length = 760 Score = 71.2 bits (173), Expect = 7e-12 Identities = 66/294 (22%), Positives = 130/294 (44%), Gaps = 4/294 (1%) Query: 1304 GSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKD 1363 G L T C R E+ F AL + P + G + + G+ A A + Sbjct: 467 GILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTA---AIRY 523 Query: 1364 FLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423 + +A+ +NP Y+ A + G L+ + + Q+A ++A+ P A+ +V + Sbjct: 524 YREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLK 583 Query: 1424 NNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482 AA Q A+K + N G ++ + +A+ +++A L P++SLA+ N Sbjct: 584 RFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 643 Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542 + + +QA +AL+ P + ++ + A +KY+E++ F I++ P Sbjct: 644 IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 703 Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEE 1596 A+ + N A Y+ +LA++ +L L P + +R K+ L+++ Sbjct: 704 AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 757 Score = 70.1 bits (170), Expect = 2e-11 Identities = 43/152 (28%), Positives = 73/152 (48%) Query: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMN 1515 G++ A++ Y++A+ LNPKY A N GNI + +A + S A++ P+ MN Sbjct: 515 GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 574 Query: 1516 RAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP 1575 I LK++E A++ + I+ + Y+N Y L ++ A A LKP Sbjct: 575 LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKP 634 Query: 1576 NDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607 +L +N + G + +A A +AL+L Sbjct: 635 EHSLAWNNMIILLDNTGNLAQAEAVGREALEL 666 >gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] Length = 519 Score = 70.1 bits (170), Expect = 2e-11 Identities = 74/310 (23%), Positives = 136/310 (43%), Gaps = 19/310 (6%) Query: 1283 LGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342 LG++ A+E + +AA +++ + + H +C+ + +F +A + AL +N L Y+ Sbjct: 114 LGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL-TYI 172 Query: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402 G ++ G + + K KA+ +P + + G G +QKA+ H A+ Sbjct: 173 MLGKIHLLEGDLDKAIEVYK---KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNAL 229 Query: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINA-AMKISTTAEFLTNRGVIHEFMGHKQN- 1460 DP NY A + G+ A+ A + + N G+ F G K+ Sbjct: 230 TYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC--FFGKKKYV 287 Query: 1461 -AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT 1519 A+ + A L P +N G ++ +Q++ A + S A+ F P+ + M A+ Sbjct: 288 AAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVA 347 Query: 1520 NTILKKYEEAKEDFANVI--ESC-PF----WAAVYFNRAHFYYCLKQYELAEEDLNKALS 1572 T L+ E AK +A + + C P +A + +N+ L QY+ E+ K Sbjct: 348 LTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEK---KVSL 404 Query: 1573 LKPNDALVYN 1582 LK N +L ++ Sbjct: 405 LKDNSSLEFD 414 Score = 50.8 bits (120), Expect = 1e-05 Identities = 59/257 (22%), Positives = 107/257 (41%), Gaps = 13/257 (5%) Query: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412 ++EA K QKD+ + ++ YI + +F KA + A++ + ++ L Y Sbjct: 124 YNEAAKLNQKDWEISHNLGVCYIYLK-----------QFNKAQDQLHNALNLN-RHDLTY 171 Query: 1413 EGRAVVCLQMGNNFAAMQDINAAMKIST-TAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471 + L G+ A++ A++ S E LT G+++ +G Q A + +A+T Sbjct: 172 IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231 Query: 1472 NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531 +P A AG++ H F A + PE+ + N + KKY A Sbjct: 232 DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAIS 291 Query: 1532 DFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKI 1591 PF + +N + ++QY A L+ A++ +P +Y A + Sbjct: 292 CLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNL 351 Query: 1592 GLIEEAMADYNQALDLE 1608 IE A Y +A+ L+ Sbjct: 352 EDIENAKRAYAEAVHLD 368 Score = 48.1 bits (113), Expect = 7e-05 Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 7/169 (4%) Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433 Y++A I + +G Q++ F P++ + A +G + AA++ N Sbjct: 71 YVQALI-----FRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYN 125 Query: 1434 AAMKISTTA-EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492 A K++ E N GV + ++ A +A+ LN ++ L Y G I+ Sbjct: 126 EAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIHLLEGDL 184 Query: 1493 SQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCP 1541 +A + + KA++F PEN +L + L Y++A E N + P Sbjct: 185 DKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233 Score = 41.6 bits (96), Expect = 0.006 Identities = 75/374 (20%), Positives = 143/374 (38%), Gaps = 25/374 (6%) Query: 1097 KYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCAL 1156 K Y+ K I + + +GL E + QALI+ N +++E+ CA+ Sbjct: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQ----------TCAV 95 Query: 1157 LAKVQM-KAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215 L+ K+ ++ +L K AI ++ + +NLG+CY+ + Sbjct: 96 LSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI----YLKQF 151 Query: 1216 KLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275 A L A++++++ + + + +L A+ Y + T L T Sbjct: 152 NKAQDQLHNALNLNRHD-LTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTL-- 208 Query: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335 GL+Y++LG Y A E A TN A +F+ A+ + ++ Sbjct: 209 -GLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKY----RVVA 263 Query: 1336 CFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKA 1394 C + N+ M + + A +A ++ P K + G ++ A Sbjct: 264 CAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASA 323 Query: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT-NRGVIHE 1453 ++ + AI+ PK Y AV + + A + A+ + + N V+ Sbjct: 324 FHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLY 383 Query: 1454 FMGHKQNAMKDYQD 1467 G K+NA+ YQ+ Sbjct: 384 NQGEKKNALAQYQE 397 Score = 35.4 bits (80), Expect = 0.45 Identities = 40/194 (20%), Positives = 74/194 (38%), Gaps = 2/194 (1%) Query: 896 KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYW 955 K YE+ ++ E++ + +A + I+R G +Q ++ Q +L P + Sbjct: 46 KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLK 105 Query: 956 HRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKST 1015 K A++ N K N+ + E + Y K A A+ Sbjct: 106 QVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN 165 Query: 1016 PTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIED 1074 D Y G+++ + + AI+ + K + + P+ T+ L GL Y + + A E Sbjct: 166 RHDL-TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEH 224 Query: 1075 FTALLNIDHQNSQA 1088 L D N +A Sbjct: 225 LGNALTYDPTNYKA 238 >gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo sapiens] Length = 860 Score = 68.9 bits (167), Expect = 4e-11 Identities = 56/241 (23%), Positives = 99/241 (41%), Gaps = 7/241 (2%) Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG-----NNFAAMQDIN 1433 ++ Y L G + +A HF+ + +P A GR + + G N A+ +++ Sbjct: 147 LAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELS 206 Query: 1434 AAMKISTTA-EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492 + + E R I +G A+ D AI L P L Y + G +YF + Sbjct: 207 RVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARL-YRHRGTLYFISEDY 265 Query: 1493 SQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAH 1552 + A + F ++L+ + ++ + +T +EA E F ++ + Y + Sbjct: 266 ATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQ 325 Query: 1553 FYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYAS 1612 Y L +E A E KAL L N R + G ++EA+ ++ + L LE Y Sbjct: 326 AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNE 385 Query: 1613 V 1613 V Sbjct: 386 V 386 Score = 67.4 bits (163), Expect = 1e-10 Identities = 55/234 (23%), Positives = 105/234 (44%), Gaps = 8/234 (3%) Query: 1198 LYNLGLCYMEEGNLQM-TYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDY 1256 +Y G+ Y ++G + +LA+ +L+ I+++ + F RA + + + A+ D Sbjct: 180 IYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDL 239 Query: 1257 GIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316 + L + + + +RG +Y Y A EDF+Q+ +++ + Sbjct: 240 TKAIQLQPSARL----YRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFH 295 Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK 1376 +EA+ F ALK F+DAY G +Y E G+ EA A + F KAL +N +++ Sbjct: 296 RGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEA---ATESFQKALLLNQNHVQ 352 Query: 1377 ARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQ 1430 G L G Q+A +F + +P N + + + + MG + ++ Sbjct: 353 TLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIK 406 Score = 62.0 bits (149), Expect = 4e-09 Identities = 51/205 (24%), Positives = 90/205 (43%), Gaps = 4/205 (1%) Query: 922 RRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYN 981 +R I LG++ A+NDL + I L+P Y HR +Y + A +D + N Sbjct: 221 QRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELN 279 Query: 982 KNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDD 1040 KN A L K + + + AI ++ +A+K D Y G+ Y E+ N A + Sbjct: 280 KNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATES 339 Query: 1041 FSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYD 1100 F K + + L RG+ + + A+++F L ++ N QY+ + + Sbjct: 340 FQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC--QYMKGLSHVA 397 Query: 1101 LAKFTIYQIAEMDKGLSELSPMQQA 1125 + +F A+ L++ P Q+A Sbjct: 398 MGQFYEGIKAQTKVMLNDPLPGQKA 422 Score = 48.5 bits (114), Expect = 5e-05 Identities = 70/299 (23%), Positives = 115/299 (38%), Gaps = 47/299 (15%) Query: 1215 YKLAITDLTTAISMDKNSYIAFYNRALCYTK-----IRELQMALTDYGIVLLLDATETVK 1269 Y AI +T + + + A Y R + Y K I+ ++AL + V+ L+ Sbjct: 159 YDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRP-- 216 Query: 1270 LNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTW 1329 E F+Q A I G RINE AVN T Sbjct: 217 ---------------------EVFEQRAEILSPLG-----------RINE---AVNDLTK 241 Query: 1330 ALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQG 1389 A+++ P Y RG Y D AT A +DF ++L +N A + G +G Sbjct: 242 AIQLQPS-ARLYRHRGTLYF-ISEDYAT--AHEDFQQSLELNKNQPIAMLYKGLTFFHRG 297 Query: 1390 KFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNR 1448 ++A F A+ AY+ ++GN AA + A+ ++ + L R Sbjct: 298 LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLR 357 Query: 1449 GVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDP 1507 G++ G Q A+K+++ + L P + + G + QF + +K + DP Sbjct: 358 GMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDP 416 Score = 47.4 bits (111), Expect = 1e-04 Identities = 55/245 (22%), Positives = 99/245 (40%), Gaps = 18/245 (7%) Query: 886 VESDLPQEVIKYYESEVKILT------EEINDKTKY-----PAFAYCRRGAIYRKLGKLQ 934 +E D P+ +E +IL+ E +ND TK A Y RG +Y Sbjct: 211 LEPDRPE----VFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYA 266 Query: 935 SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEI 994 +A D Q+ + L A ++ L + + + EA++ K + +AY S + Sbjct: 267 TAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQA 326 Query: 995 YRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM-YEITNKVLAIDDFSKCIFYDPKRTD 1053 YR + A ++ +A+ RG M Y + A+ +F +C+ +P Sbjct: 327 YRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 386 Query: 1054 ALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMD 1113 +GL + ++ I+ T ++ D Q L +KY L +++ Y A +D Sbjct: 387 CQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKY--LREYSRYLHAHLD 444 Query: 1114 KGLSE 1118 L+E Sbjct: 445 TPLTE 449 Score = 43.5 bits (101), Expect = 0.002 Identities = 47/246 (19%), Positives = 95/246 (38%), Gaps = 38/246 (15%) Query: 1320 FEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG-HD-EATKQAQKDFLKALHINPAYIKA 1377 ++EA+ F+ L+ P + A GRG +Y + G HD + + A + + + + P + Sbjct: 159 YDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEV 218 Query: 1378 RISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK 1437 L G+ +A N T AI P L Y R + + A +D +++ Sbjct: 219 FEQRAEILSPLGRINEAVNDLTKAIQLQPSARL-YRHRGTLYFISEDYATAHEDFQQSLE 277 Query: 1438 ISTTAEFLT--------NRGVIHEF---------------------------MGHKQNAM 1462 ++ +RG++ E +G+ + A Sbjct: 278 LNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAAT 337 Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522 + +Q A+ LN + G + +HH +A F + L+ +P NE + +++ Sbjct: 338 ESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVA 397 Query: 1523 LKKYEE 1528 + ++ E Sbjct: 398 MGQFYE 403 >gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] Length = 2481 Score = 65.1 bits (157), Expect = 5e-10 Identities = 149/680 (21%), Positives = 276/680 (40%), Gaps = 92/680 (13%) Query: 1000 DITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKCIFYDPKRTDALLKR 1058 D AI+ Y +A+ P + +Y R Y +I A+DD K +PK A ++ Sbjct: 73 DFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQ 132 Query: 1059 GLFYCENENWFAAIEDFTALLNIDHQNSQAR-GQYLLMMK--YYDLAKFTIYQIAEMDKG 1115 G+ A+ F + L D ++ Q G MK D + T Q+ +M Sbjct: 133 GVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLD 192 Query: 1116 LSE---LSPMQQALIYSFCENHDKAIEVLD-----GISWNRAEMTMCALLAKVQMKAKRT 1167 S +S + Q L+ + +H ++ VL+ G + ++ + L+ T Sbjct: 193 KSPFVVVSVVGQELLTA--GHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNT 250 Query: 1168 KEAVEVLKKALD-AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITD----- 1221 +++ +++ LD A + D+ + A NLG + +GN Y+ A+T+ Sbjct: 251 EKSTGYMQQDLDVAKTLGDQTGECRAHG-----NLGSAFFSKGN----YREALTNHRHQL 301 Query: 1222 -LTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLL---DATETVKLNTFLNRG 1277 L + + + A + YT I + AL + +LL E + N G Sbjct: 302 VLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMG 361 Query: 1278 LIYVELGQYGFALEDFKQAALISRTNG-------SLCHATAMCHHRINEFEEAVNFFTWA 1330 +Y+ +G + A++ +Q I++ G + + + H+R N F++A+++ + Sbjct: 362 AVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRN-FDKAMSYHNYV 420 Query: 1331 LKINPCFLD------AYVGRGNSYMEYGHDEATKQ---AQKDFLKALHINPAYIKARISF 1381 L++ ++ AY G G++ E KQ Q + L A +A + Sbjct: 421 LELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL 480 Query: 1382 GYNLQAQGKFQKAWN-HFT-IAIDTDPKNYLAYEGRAVVCLQMGNNFAAM---------- 1429 G Q +G + A H T + I + +Y A +GRA MGN + A+ Sbjct: 481 GIIHQMKGDYDTALKLHKTHLCIAQELSDYAA-QGRAYG--NMGNAYNALGMYDQAVKYH 537 Query: 1430 -QDINAAMKISTTAEFLTNRG---VIHEFMGHKQNAMKDYQDAITLNPKY------SLAY 1479 Q++ +M+++ A + G V ++ +G A++ YQ+ + + + + A Sbjct: 538 RQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARAL 597 Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENE------YVLMNRAITNTILKKYEEAKEDF 1533 N GN + ++ QA+ Y+ + L+ P+ + V N + L Y+EA + + Sbjct: 598 SNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYY 657 Query: 1534 ------ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKV 1587 A + A Y N + L + AEE LSL + + N +AK Sbjct: 658 EQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS---LNNSQAKF 714 Query: 1588 R--GKIGLIEEAMADYNQAL 1605 R G +G I D N A+ Sbjct: 715 RALGNLGDIFICKKDINGAI 734 Score = 40.4 bits (93), Expect = 0.014 Identities = 94/467 (20%), Positives = 161/467 (34%), Gaps = 118/467 (25%) Query: 1215 YKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFL 1274 + AI A+++D + I + NR+ Y KI++ AL D LL+ + Sbjct: 74 FHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWP---KAYF 130 Query: 1275 NRGLIYVELGQYGFALEDFK-----------------QAALISRTNGSL----------- 1306 +G+ LG++ AL F +AA+ S SL Sbjct: 131 RQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMK 190 Query: 1307 -------------CHATAMCHH--RINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEY 1351 HH + E A+ T +LK+ A ++Y Sbjct: 191 LDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL---SSAYWSL 247 Query: 1352 GHDEATK---QAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAW-NH---FTIAIDT 1404 G+ E + Q D K L +A + G ++G +++A NH +A+ Sbjct: 248 GNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKL 307 Query: 1405 DPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS--------------TTAEFLTNRGV 1450 + E + +G+ + A+ D A+ + A L N G Sbjct: 308 KDR-----EAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGA 362 Query: 1451 IHEFMGHKQNAMKDYQDAITL------NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALK 1504 ++ MG +NA++ ++ + + + + AY N G+ Y + R F +A Y + L+ Sbjct: 363 VYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLE 422 Query: 1505 FDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA- 1563 E LM +AI Y H C++ E A Sbjct: 423 LAQE----LMEKAIE------------------------MRAYAGLGHAARCMQDLERAK 454 Query: 1564 ---EEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607 E+ L A LK A + +G+I + DY+ AL L Sbjct: 455 QYHEQQLGIAEDLKDRAA-----EGRASSNLGIIHQMKGDYDTALKL 496 Score = 40.0 bits (92), Expect = 0.018 Identities = 103/464 (22%), Positives = 175/464 (37%), Gaps = 86/464 (18%) Query: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDK------------NSY--IAFYNRALCYTK 1245 NLG+ + +G+ KL T L A + N+Y + Y++A+ Y + Sbjct: 479 NLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHR 538 Query: 1246 IRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGS 1305 +ELQ+++ + +T N + Y LG + AL+ ++ I+R Sbjct: 539 -QELQISMEVND--------RASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRD 589 Query: 1306 L-CHATAMC-----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGN-----SYMEY--- 1351 + A A+ H E+ +A ++ L++ P D G G Y Y Sbjct: 590 IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDME-GEGKVCHNLGYAHYCLG 648 Query: 1352 GHDEATKQAQKDFL--KALHINPAYIKARISFGYNLQAQGKFQKA--WNHFTIAIDTDPK 1407 + EA K ++D K LH + KA + G +A F KA + +++ Sbjct: 649 NYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLN 708 Query: 1408 NYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQD 1467 N A + RA+ +G+ F +DIN A+K + G+ H+ + A Sbjct: 709 NSQA-KFRALG--NLGDIFICKKDINGAIKF-----YEQQLGLAHQVKDRRLEAS----- 755 Query: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENE-------------YVLM 1514 AY G Y +++ +A Y ++ L+ E V M Sbjct: 756 ----------AYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYM 805 Query: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA----EEDLNKA 1570 K YEE + D ++ A VY N + E A E+ L Sbjct: 806 ALGKYTMAFKCYEE-QLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864 Query: 1571 LSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALD-LEDYASV 1613 L N++++ R + G +G EA+ DY +A+ E Y SV Sbjct: 865 QQLSGNESVLD--RGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906 Score = 38.1 bits (87), Expect = 0.069 Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 5/96 (5%) Query: 1313 CHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372 CH +F A+ + AL ++P Y R +YM+ + +A D +KA +NP Sbjct: 69 CHD--GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKI---QQYDKALDDAIKARLLNP 123 Query: 1373 AYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN 1408 + KA G LQ G+ A F + DPK+ Sbjct: 124 KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKS 159 Score = 35.8 bits (81), Expect = 0.34 Identities = 127/625 (20%), Positives = 216/625 (34%), Gaps = 145/625 (23%) Query: 892 QEVIKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFL 951 QE +KYYE ++ L ++++DK A AYC G ++ L A Sbjct: 651 QEAVKYYEQDL-ALAKDLHDKLS-QAKAYCNLGLAFKALLNFSKAEE------------- 695 Query: 952 NAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQ- 1010 ++L+ L Q N ++ A + +I+ KKDI AI Y Q Sbjct: 696 ---CQKYLLSLAQSLNN------------SQAKFRALGNLGDIFICKKDINGAIKFYEQQ 740 Query: 1011 -----AIKSTPTDADIYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLF--YC 1063 +K +A Y G Y + K + K + Y + + + C Sbjct: 741 LGLAHQVKDRRLEASAYAALGTAYRMIQK------YDKALGYHTQELEVYQELSDLPGEC 794 Query: 1064 ENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQ 1123 AA+ A G+Y + K Y+ ++D G P Sbjct: 795 RAHGHLAAV-------------YMALGKYTMAFKCYE---------EQLDLGQKLKDPSL 832 Query: 1124 QALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISH 1183 +A +Y + +M +EA+ ++ L A+ Sbjct: 833 EAQVY--------------------------GNMGITKMNMNVMEEAIGYFEQQL-AMLQ 865 Query: 1184 SDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRAL-- 1241 G ++ NLG CY G+ + K L+ A S+++ A R L Sbjct: 866 QLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGN 925 Query: 1242 CYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISR 1301 + + LQ AL + L++ +L N+ Y ELG L +++QA Sbjct: 926 GHRAMGSLQQALVCFEKRLVV----AHELGEAFNKAQAYGELGSLHSQLGNYEQA----- 976 Query: 1302 TNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG-HDEATKQA 1360 I+ E +N +K DA G G Y + G +D A + Sbjct: 977 ---------------ISCLERQLN-IARDMKDRALESDAACGLGGVYQQMGEYDTALQYH 1020 Query: 1361 QKDFLKALHINPAYIKARI--SFGYNLQAQGKFQKA----WNHFTIAIDTDPKNYLAYEG 1414 Q D A N + R + G ++ G F++A H +IA N LA Sbjct: 1021 QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQ---MNDLA--A 1075 Query: 1415 RAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPK 1474 + V +G A+Q+ + A+ +L + E +G +++ K + Sbjct: 1076 KTVSYSSLGRTHHALQNYSQAVM------YLQEGLRLAEQLGRREDEAK-------IRHG 1122 Query: 1475 YSLAYFNAGNIYFHHRQFSQASDYF 1499 L+ + +GN+ Q +AS F Sbjct: 1123 LGLSLWASGNLEEAQHQLYRASALF 1147 Score = 33.5 bits (75), Expect = 1.7 Identities = 17/63 (26%), Positives = 30/63 (47%) Query: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVY 1547 H F A +++AL DP+N + NR+ +++Y++A +D P W Y Sbjct: 70 HDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAY 129 Query: 1548 FNR 1550 F + Sbjct: 130 FRQ 132 >gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1 [Homo sapiens] Length = 494 Score = 62.4 bits (150), Expect = 3e-09 Identities = 87/386 (22%), Positives = 156/386 (40%), Gaps = 44/386 (11%) Query: 1261 LLDATETVK-LNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINE 1319 LLD E + TF +G Y Y A + +A + N S A + Sbjct: 18 LLDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGR 77 Query: 1320 FEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARI 1379 F EA+ +++++ F+ ++ G ++ G+ A A + F +AL ++ +A+ Sbjct: 78 FREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMA---ACRSFQRALELDHKNAQAQQ 134 Query: 1380 SFG-------YNLQAQGKFQKAWNHFTI-----AIDTDPKNYLAYEGRAVVCLQMGNNFA 1427 F Y A+ F+K + A++ P + ++ CL M + Sbjct: 135 EFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACH-RFKILKAECLAMLGRYP 193 Query: 1428 AMQDINAAM--KISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP---KYSLAYFNA 1482 Q + + + ST A+ L RG+ + + A++ + A+ + P K +A NA Sbjct: 194 EAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNA 253 Query: 1483 ---------GNIYFHHRQFSQASDYFSKALKFDPEN----EYVLMNRAITNTILKKYEEA 1529 GN F + A + +++AL DP N + NR N+ L+K ++A Sbjct: 254 KALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDA 313 Query: 1530 KEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKAL---SLKPNDALVYNFRAK 1586 ED N ++ + Y RA Y +QYE A D K K + L+ N + + Sbjct: 314 IEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLKNAQLE 373 Query: 1587 VRGKIGLIEEAMADYNQALDLEDYAS 1612 +R + DY + L ++ AS Sbjct: 374 LR------KSKRKDYYKILGVDKNAS 393 Score = 53.1 bits (126), Expect = 2e-06 Identities = 81/356 (22%), Positives = 131/356 (36%), Gaps = 63/356 (17%) Query: 969 EALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM 1028 E LDD + K E + + Y KKD A YT+AI P +A Y R Sbjct: 17 ELLDD-----QEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAAT 71 Query: 1029 YEITNKVL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQ 1087 + + A+ D + + D L+ G + N AA F L +DH+N+Q Sbjct: 72 LMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQ 131 Query: 1088 ARGQYL---LMMKYYDLAKFTIYQ------IAEMDKGLSELSPMQQ----------ALIY 1128 A+ ++ +M+Y +A+ + + MD+ L E +P A++ Sbjct: 132 AQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRAL-EFAPACHRFKILKAECLAMLG 190 Query: 1129 SFCENHDKAIEVLDGISWNRAEMTMCAL-LAKVQMKAKRTKEAVEVLKKALDAISHSDKG 1187 + E A ++L S N + + L L K + V+ L+ A D Sbjct: 191 RYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIAC 250 Query: 1188 PDATAISADCLYNLGLCYMEEGNLQMTYKL------------------------------ 1217 +A A+ A G +EGN ++ Y+L Sbjct: 251 RNAKALKAK--KEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLR 308 Query: 1218 ----AITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVK 1269 AI D T A+ +D A+ RA CY + + A+ DY V + T+ K Sbjct: 309 KLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHK 364 Score = 45.4 bits (106), Expect = 4e-04 Identities = 26/97 (26%), Positives = 44/97 (45%), Gaps = 3/97 (3%) Query: 898 YESEVKILTEEIN---DKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954 Y+ ++ TE + + K A YC RG + KL KL A+ D + L+ ++ AY Sbjct: 272 YKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAY 331 Query: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK 991 R Y+ ++ EA+ D +++ K L K Sbjct: 332 LRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLK 368 >gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo sapiens] Length = 665 Score = 61.2 bits (147), Expect = 8e-09 Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 14/268 (5%) Query: 1355 EATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG 1414 E+ Q + +H++ G QGK+ +A + +T +D DP N + Sbjct: 113 ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTN 172 Query: 1415 RAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473 RA ++ A D N A+ ++ + + + RG + + A KDY+ + L P Sbjct: 173 RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232 Query: 1474 ----------KYSLAYFNAGNIYFHHRQFS-QASDYFSKALKFDPENEYVLMNRAITNTI 1522 K S A + N Y ++++ K ++ + + + N Sbjct: 233 NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292 Query: 1523 LK--KYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580 K KYE A E + I + A + NRA Y +++YE AE+D +A+ L + + Sbjct: 293 FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352 Query: 1581 YNFRAKVRGKIGLIEEAMADYNQALDLE 1608 + R R +G + EA D+ L LE Sbjct: 353 FARRGTARTFLGKLNEAKQDFETVLLLE 380 Score = 58.9 bits (141), Expect = 4e-08 Identities = 35/120 (29%), Positives = 59/120 (49%) Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548 H SQ S+ + D + VL + KY+EA + + +++ P+ + Sbjct: 112 HESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT 171 Query: 1549 NRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 NRA Y+ LK++ +AE D N A++L + Y+ R R + +EEA DY + L+LE Sbjct: 172 NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 231 Score = 43.5 bits (101), Expect = 0.002 Identities = 66/292 (22%), Positives = 117/292 (40%), Gaps = 61/292 (20%) Query: 1022 YFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNI 1081 YF++G+ E AID ++K + DP R Y + + A D + + Sbjct: 143 YFKQGKYDE------AIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVAL 196 Query: 1082 DHQNSQA---RGQYLLMMKYYDLAKFTIYQIAEMD----KGLSELSPMQQALIY---SFC 1131 + ++A RG ++ + AK ++ E++ + +EL + QAL S+ Sbjct: 197 NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYP 256 Query: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191 + D I+ +G + Q++A++ K+ AIS D+G Sbjct: 257 KEADIVIKSTEG--------------ERKQIEAQQNKQ---------QAISEKDRGNG-- 291 Query: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251 + +EG Y+ AI T I+ D + + NRA+ Y KI++ + Sbjct: 292 -------------FFKEGK----YERAIECYTRGIAADGANALLPANRAMAYLKIQKYEE 334 Query: 1252 ALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN 1303 A D +LLD + + F RG LG+ A +DF+ L+ N Sbjct: 335 AEKDCTQAILLDGSYS---KAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383 Score = 38.5 bits (88), Expect = 0.053 Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 35/220 (15%) Query: 919 AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978 AY RRGA L KL+ A D +RV+ LEP N + EA ++L I Sbjct: 203 AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 245 Query: 979 KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034 + + +Y +A+I G++ A N QAI S + +F+ G+ YE Sbjct: 246 QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 299 Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA---RGQ 1091 AI+ +++ I D R + Y + + + A +D T + +D S+A RG Sbjct: 300 -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 358 Query: 1092 YLLMMKYYDLAKFTIYQIAEMDKG----LSELSPMQQALI 1127 + + AK + ++ G ++ELS +++ LI Sbjct: 359 ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELI 398 Score = 34.7 bits (78), Expect = 0.77 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%) Query: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334 +RG + + G+Y A+E + + N L AM + +I ++EEA T A+ ++ Sbjct: 287 DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 346 Query: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372 + A+ RG + G +A++DF L + P Sbjct: 347 GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 381 Score = 34.3 bits (77), Expect = 1.0 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%) Query: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948 I+ YE K T+ I Y A+ RRG LGKL A D + V+LLEP Sbjct: 329 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 381 >gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo sapiens] Length = 807 Score = 60.1 bits (144), Expect = 2e-08 Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 16/227 (7%) Query: 1387 AQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT 1446 +Q K F A D D N E A+ + +G+ A ST + L+ Sbjct: 123 SQAKSIAEQKRFPFATDNDSTN----EELAIAYVLIGSGLYD----EAIRHFSTMLQILS 174 Query: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506 G I+E A+ D AI L P L Y + G +YF ++ A + F ++L+ + Sbjct: 175 PLGRINE-------AVNDLTKAIQLQPSARL-YRHRGTLYFISEDYATAHEDFQQSLELN 226 Query: 1507 PENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEED 1566 ++ + +T +EA E F ++ + Y + Y L +E A E Sbjct: 227 KNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATES 286 Query: 1567 LNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASV 1613 KAL L N R + G ++EA+ ++ + L LE Y V Sbjct: 287 FQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333 Score = 60.1 bits (144), Expect = 2e-08 Identities = 50/201 (24%), Positives = 88/201 (43%), Gaps = 4/201 (1%) Query: 926 IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985 I LG++ A+NDL + I L+P Y HR +Y + A +D + NKN Sbjct: 172 ILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230 Query: 986 EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKC 1044 A L K + + + AI ++ +A+K D Y G+ Y E+ N A + F K Sbjct: 231 IAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290 Query: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKF 1104 + + L RG+ + + A+++F L ++ N QY+ + + + +F Sbjct: 291 LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC--QYMKGLSHVAMGQF 348 Query: 1105 TIYQIAEMDKGLSELSPMQQA 1125 A+ L++ P Q+A Sbjct: 349 YEGIKAQTKVMLNDPLPGQKA 369 Score = 58.5 bits (140), Expect = 5e-08 Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 7/172 (4%) Query: 1263 DATETVKLNT----FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRIN 1318 D T+ ++L + +RG +Y Y A EDF+Q+ +++ + Sbjct: 185 DLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRG 244 Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378 +EA+ F ALK F+DAY G +Y E G+ EA A + F KAL +N +++ Sbjct: 245 LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEA---ATESFQKALLLNQNHVQTL 301 Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQ 1430 G L G Q+A +F + +P N + + + + MG + ++ Sbjct: 302 QLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIK 353 Score = 51.6 bits (122), Expect = 6e-06 Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 14/245 (5%) Query: 886 VESDLPQEVIKYYESEVKILT------EEINDKTKY-----PAFAYCRRGAIYRKLGKLQ 934 + S L E I+++ + ++IL+ E +ND TK A Y RG +Y Sbjct: 154 IGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYA 213 Query: 935 SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEI 994 +A D Q+ + L A ++ L + + + EA++ K + +AY S + Sbjct: 214 TAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQA 273 Query: 995 YRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM-YEITNKVLAIDDFSKCIFYDPKRTD 1053 YR + A ++ +A+ RG M Y + A+ +F +C+ +P Sbjct: 274 YRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333 Query: 1054 ALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMD 1113 +GL + ++ I+ T ++ D Q L +KY L +++ Y A +D Sbjct: 334 CQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKY--LREYSRYLHAHLD 391 Query: 1114 KGLSE 1118 L+E Sbjct: 392 TPLTE 396 Score = 47.4 bits (111), Expect = 1e-04 Identities = 60/245 (24%), Positives = 97/245 (39%), Gaps = 19/245 (7%) Query: 1264 ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEA 1323 AT+ N L + + G Y A+ F I G RINE A Sbjct: 137 ATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLG-----------RINE---A 182 Query: 1324 VNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383 VN T A+++ P Y RG Y D AT A +DF ++L +N A + G Sbjct: 183 VNDLTKAIQLQPS-ARLYRHRGTLYF-ISEDYAT--AHEDFQQSLELNKNQPIAMLYKGL 238 Query: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-A 1442 +G ++A F A+ AY+ ++GN AA + A+ ++ Sbjct: 239 TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHV 298 Query: 1443 EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKA 1502 + L RG++ G Q A+K+++ + L P + + G + QF + +K Sbjct: 299 QTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358 Query: 1503 LKFDP 1507 + DP Sbjct: 359 MLNDP 363 >gi|83415184 transmembrane and tetratricopeptide repeat containing 1 [Homo sapiens] Length = 774 Score = 60.1 bits (144), Expect = 2e-08 Identities = 67/305 (21%), Positives = 119/305 (39%), Gaps = 41/305 (13%) Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 EEA+ ++K P F DAY + E E K+A++ + + P + Sbjct: 457 EEAITLLKDSIKYGPEFADAYSSLASLLAE---QERFKEAEEIYQTGIKNCPDSSDLHNN 513 Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440 +G L G +KA H+ AI P +++A + +G N A + A++++ Sbjct: 514 YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573 Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP-----KYSLA----------------- 1478 AE L+ G ++ G + A++ YQ+A L P + +LA Sbjct: 574 KAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTN 633 Query: 1479 ------------YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT--NTILK 1524 Y IY +A D KAL+ P++ V+ T N + + Sbjct: 634 HIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLRE 693 Query: 1525 K--YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582 + ++A E + ++ P A + N + +Y A +AL L P+ L+ Sbjct: 694 QNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKE 753 Query: 1583 FRAKV 1587 AK+ Sbjct: 754 NLAKL 758 Score = 55.5 bits (132), Expect = 4e-07 Identities = 66/325 (20%), Positives = 130/325 (40%), Gaps = 44/325 (13%) Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 +EA+ + ALK+ P A G + T +A+ + +AL ++P + +A + Sbjct: 392 KEAIYHYRTALKLYPRHASALNNLGTLTRD------TAEAKMYYQRALQLHPQHNRALFN 445 Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-IS 1439 G L++Q K ++A +I P+ AY A + + A + +K Sbjct: 446 LGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCP 505 Query: 1440 TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYF 1499 +++ N GV G + A+ YQ AI L+P + +A N G +Y + S A +++ Sbjct: 506 DSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWY 565 Query: 1500 SKALK---------------------------------FDPENEYVLMNRAITNTILKKY 1526 +AL+ P + + A ++ + Sbjct: 566 KRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQT 625 Query: 1527 EEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAK 1586 +EA++ +++ Y + Y + ++ A + ++KAL LKP D V + Sbjct: 626 KEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685 Query: 1587 VRG----KIGLIEEAMADYNQALDL 1607 +G + L+++A Y A+ L Sbjct: 686 TKGNQLREQNLLDKAFESYRVAVQL 710 Score = 53.9 bits (128), Expect = 1e-06 Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 8/220 (3%) Query: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMG 1456 F + T P N + A G N A+ A+K+ A L N G + Sbjct: 364 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR--- 420 Query: 1457 HKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNR 1516 A YQ A+ L+P+++ A FN GN+ + +A ++K+ PE + Sbjct: 421 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480 Query: 1517 AITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPN 1576 A ++++EA+E + I++CP + ++ N F E A +A+ L P+ Sbjct: 481 ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540 Query: 1577 DALVYNFRAKVRGKIGLIEEAMAD--YNQALDLEDYASVI 1614 + ++ +G E +MA+ Y +AL + A ++ Sbjct: 541 HHVAMVNLGRLYRSLG--ENSMAEEWYKRALQVAHKAEIL 578 Score = 53.9 bits (128), Expect = 1e-06 Identities = 55/283 (19%), Positives = 109/283 (38%), Gaps = 42/283 (14%) Query: 1291 EDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFTWALKINPCFLDAYVG 1343 E FK+A I +T C ++ H+ F E+AV + A+K++P A V Sbjct: 488 ERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVN 547 Query: 1344 RGNSYMEYGHDEATKQAQKDFLKALH------------------------------INPA 1373 G Y G + ++ K L+ H + P+ Sbjct: 548 LGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607 Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433 + R++ L G+ ++A + + Y + + + N+ A+ I+ Sbjct: 608 QRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAID 667 Query: 1434 AAMKIS-----TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFH 1488 A+++ +E +G A + Y+ A+ LNP + A+ N G I Sbjct: 668 KALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHI 727 Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531 ++ A Y+ +AL+ P+++ + N A + + K+ +E +E Sbjct: 728 KGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVRE 770 Score = 38.1 bits (87), Expect = 0.069 Identities = 61/264 (23%), Positives = 92/264 (34%), Gaps = 42/264 (15%) Query: 920 YCRRGAIYRKLGKLQ----SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLN 975 Y R + LG L A QR + L P A ++ + Q+K EA+ L Sbjct: 405 YPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 464 Query: 976 YIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN-K 1034 KY +AY S A + ++ A Y IK+ P +D++ G T Sbjct: 465 DSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLP 524 Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFY---CEN---ENWF------------------- 1069 A+ + + I P A++ G Y EN E W+ Sbjct: 525 EKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGAL 584 Query: 1070 -----------AAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSE 1118 ++ AL + A Q L +M A+ I + G E Sbjct: 585 YYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLE 644 Query: 1119 LSPMQQALIYSFCENHDKAIEVLD 1142 + A IYS ENHDKA++ +D Sbjct: 645 CYRLLSA-IYSKQENHDKALDAID 667 >gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo sapiens] Length = 631 Score = 58.9 bits (141), Expect = 4e-08 Identities = 35/120 (29%), Positives = 59/120 (49%) Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548 H SQ S+ + D + VL + KY+EA + + +++ P+ + Sbjct: 112 HESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT 171 Query: 1549 NRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 NRA Y+ LK++ +AE D N A++L + Y+ R R + +EEA DY + L+LE Sbjct: 172 NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 231 Score = 54.7 bits (130), Expect = 7e-07 Identities = 33/122 (27%), Positives = 58/122 (47%) Query: 1466 QDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525 +D I ++ + +L GN YF ++ +A D ++K + DP N + NRA LKK Sbjct: 123 EDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKK 182 Query: 1526 YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRA 1585 + A+ D + + Y R + L++ E A++D + L L+PN+ N Sbjct: 183 FAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELR 242 Query: 1586 KV 1587 K+ Sbjct: 243 KI 244 Score = 53.1 bits (126), Expect = 2e-06 Identities = 57/305 (18%), Positives = 115/305 (37%), Gaps = 50/305 (16%) Query: 1355 EATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG 1414 E+ Q + +H++ G QGK+ +A + +T +D DP N + Sbjct: 113 ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTN 172 Query: 1415 RAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473 RA ++ A D N A+ ++ + + + RG + + A KDY+ + L P Sbjct: 173 RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232 Query: 1474 -----------------------------------------------KYSLAYFNAGNIY 1486 + +++ + GN + Sbjct: 233 NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292 Query: 1487 FHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAV 1546 F ++ +A + +++ + D N + NRA+ ++KYEEA++D I ++ Sbjct: 293 FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352 Query: 1547 YFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGK--IGLIEEAMADYNQA 1604 + R L + A++D L L+P + +K++ K +I E + Q Sbjct: 353 FARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKKPLKKVIIEETGNLIQT 412 Query: 1605 LDLED 1609 +D+ D Sbjct: 413 IDVPD 417 Score = 43.5 bits (101), Expect = 0.002 Identities = 66/292 (22%), Positives = 117/292 (40%), Gaps = 61/292 (20%) Query: 1022 YFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNI 1081 YF++G+ E AID ++K + DP R Y + + A D + + Sbjct: 143 YFKQGKYDE------AIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVAL 196 Query: 1082 DHQNSQA---RGQYLLMMKYYDLAKFTIYQIAEMD----KGLSELSPMQQALIY---SFC 1131 + ++A RG ++ + AK ++ E++ + +EL + QAL S+ Sbjct: 197 NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYP 256 Query: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191 + D I+ +G + Q++A++ K+ AIS D+G Sbjct: 257 KEADIVIKSTEG--------------ERKQIEAQQNKQ---------QAISEKDRGNG-- 291 Query: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251 + +EG Y+ AI T I+ D + + NRA+ Y KI++ + Sbjct: 292 -------------FFKEGK----YERAIECYTRGIAADGANALLPANRAMAYLKIQKYEE 334 Query: 1252 ALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN 1303 A D +LLD + + F RG LG+ A +DF+ L+ N Sbjct: 335 AEKDCTQAILLDGSYS---KAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383 Score = 36.6 bits (83), Expect = 0.20 Identities = 47/174 (27%), Positives = 76/174 (43%), Gaps = 28/174 (16%) Query: 919 AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978 AY RRGA L KL+ A D +RV+ LEP N + EA ++L I Sbjct: 203 AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 245 Query: 979 KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034 + + +Y +A+I G++ A N QAI S + +F+ G+ YE Sbjct: 246 QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 299 Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA 1088 AI+ +++ I D R + Y + + + A +D T + +D S+A Sbjct: 300 -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352 Score = 34.7 bits (78), Expect = 0.77 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%) Query: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334 +RG + + G+Y A+E + + N L AM + +I ++EEA T A+ ++ Sbjct: 287 DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 346 Query: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372 + A+ RG + G +A++DF L + P Sbjct: 347 GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 381 Score = 34.3 bits (77), Expect = 1.0 Identities = 24/87 (27%), Positives = 37/87 (42%), Gaps = 2/87 (2%) Query: 923 RGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNK 982 R Y K+ K + A D + ILL+ + A+ R F K+NEA D + Sbjct: 322 RAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEP 381 Query: 983 NNTEAYLSKAEIYRGKKDITLAILNYT 1009 N +A ++I KK + I+ T Sbjct: 382 GNKQAVTELSKI--KKKPLKKVIIEET 406 Score = 34.3 bits (77), Expect = 1.0 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%) Query: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948 I+ YE K T+ I Y A+ RRG LGKL A D + V+LLEP Sbjct: 329 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 381 >gi|224809432 transmembrane and tetratricopeptide repeat containing 3 [Homo sapiens] Length = 914 Score = 58.5 bits (140), Expect = 5e-08 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%) Query: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 F A +++ N L + FE A+ +F A + P + A++ G +Y Sbjct: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494 Query: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397 TK+A++ ++ A I P ++ I+ ++A + + ++A Sbjct: 495 R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551 Query: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456 + AI P AY R + L+M A + A+++ A+ N ++H + Sbjct: 552 YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611 Query: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479 A+K++ A+ LNPK+ LA Y Sbjct: 612 EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525 FN G + ++ ++A + KA+K + L N A I +L+ Sbjct: 672 FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731 Query: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564 Y + AK+ F ++E P N Y+ K AE Sbjct: 732 YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791 Query: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591 L + L+L P++ + VR KI Sbjct: 792 RCLLETLALAPHEEYIQRHLNIVRDKI 818 Score = 55.5 bits (132), Expect = 4e-07 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%) Query: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352 FK+ + I + L H+ HR ++E F ALK+N + G++ Sbjct: 402 FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457 Query: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412 +++ ++A K FL+A H+ P I A ++ G + + ++A + +A P+ Sbjct: 458 NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512 Query: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472 + G +AA N ++ +I + A + Y+ AI++ Sbjct: 513 -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559 Query: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532 P + AY + G + + +A + + KAL+ D N + N AI + LK+ EA ++ Sbjct: 560 PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619 Query: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581 F +E P FN A + +L E + LS +P DA Y Sbjct: 620 FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671 Score = 43.9 bits (102), Expect = 0.001 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%) Query: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332 +++RG + +++ + A E + +A + R N L + A+ H + E EA+ F AL+ Sbjct: 566 YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625 Query: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392 +NP A E G + +A+K L ++ P + G K Sbjct: 626 LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685 Query: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449 +A W I + D ++ A A++ Q A+ + ++ + L +G Sbjct: 686 EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743 Query: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506 I M K++ A K ++ + ++P N +YF + +A + L Sbjct: 744 DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801 Query: 1507 PENEYV 1512 P EY+ Sbjct: 802 PHEEYI 807 Score = 39.3 bits (90), Expect = 0.031 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%) Query: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492 +A+K++ A+ N G E + + A+K + A + P A+ N G Y + + Sbjct: 437 SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496 Query: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535 +A + + A P+ N Y+ L N N + EEA + + Sbjct: 497 KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554 Query: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595 I P + Y +R + + A+E KAL L N+A ++ A V ++ Sbjct: 555 AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614 Query: 1596 EAMADYNQALDL 1607 EA+ ++N+AL+L Sbjct: 615 EALKNFNRALEL 626 Score = 32.3 bits (72), Expect = 3.8 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%) Query: 976 YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034 Y + N+ Y++ A + R + + A Y QAI P Y RGE+ NK Sbjct: 519 YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578 Query: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093 L A + + K + D D + + E + A+++F L ++ ++ A Sbjct: 579 PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638 Query: 1094 LMMK 1097 ++M+ Sbjct: 639 IVMQ 642 >gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens] Length = 873 Score = 55.5 bits (132), Expect = 4e-07 Identities = 74/321 (23%), Positives = 134/321 (41%), Gaps = 34/321 (10%) Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378 ++E AV F+ AL ++P +D Y R +Y++ + Q + N +++ R Sbjct: 76 DWETAVLLFSRALHLDPQLVDFYALRAEAYLQLCDFSSAAQNLRRAYSLQQDNCKHLE-R 134 Query: 1379 ISFGYNLQAQGKFQK-----AWNHFTIAIDTDPKNYLAYEGRAVVC-LQMGNNFAAMQDI 1432 ++F LQ Q F++ A N F+ A + P+ + R + C L + + A + I Sbjct: 135 LTFVLYLQGQCLFEQCAFLDALNVFSHAAELQPEK-PCFRYRCMACLLALKQHQACLTLI 193 Query: 1433 NAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQ 1491 +K TT A+ R ++ F+ +D A+ LNPK+ A + +Q Sbjct: 194 TNELKQDTTNADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQ 253 Query: 1492 FSQ-------------ASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIE 1538 Q A ++A++ +P + + + R L++++ A EDF V++ Sbjct: 254 ARQDAGILAVQGKLQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLD 313 Query: 1539 SCPFWAAVYFNRAH----------FYYCLKQ--YELAEEDLNKALSLKPNDALVYNFRAK 1586 +A +C +Q Y+ LNKAL + + +Y R Sbjct: 314 MVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGD 373 Query: 1587 VRGKIGLIEEAMADYNQALDL 1607 ++G + A ADY QAL L Sbjct: 374 CFFQLGNLAFAEADYQQALAL 394 Score = 50.8 bits (120), Expect = 1e-05 Identities = 103/500 (20%), Positives = 181/500 (36%), Gaps = 101/500 (20%) Query: 1049 PKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQ 1108 P + RG E +W A+ F+ L++D Q ++ +Y L Q Sbjct: 58 PLKVREYYSRGQQCLEQADWETAVLLFSRALHLDPQ----------LVDFYALRAEAYLQ 107 Query: 1109 IAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAE--MTMCALLAKVQMKAKR 1166 + + L YS +++ K +E L + + + + CA L Sbjct: 108 LCDFSSAAQNLRRA-----YSLQQDNCKHLERLTFVLYLQGQCLFEQCAFL--------- 153 Query: 1167 TKEAVEVLKKALDAISHS-DKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTA 1225 AL+ SH+ + P+ C+ C + ++ +T +T Sbjct: 154 ---------DALNVFSHAAELQPEKPCFRYRCM----ACLLA----LKQHQACLTLITNE 196 Query: 1226 ISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQ 1285 + D + + RA Y +++ + D LLL+ R L+ + Q Sbjct: 197 LKQDTTNADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQA------RMLLQKMVAQ 250 Query: 1286 YGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRG 1345 + +Q A I G L HA RIN A++ NP ++ RG Sbjct: 251 ----AQQARQDAGILAVQGKLQHAL----QRINR----------AIENNPLDPSLFLFRG 292 Query: 1346 NSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTD 1405 Y + A +DFLK L + + + QAQ + +N F Sbjct: 293 TMYRRLQEFDG---AVEDFLKVLDMVTEDQEDMVR-----QAQRQLLLTYNDF------- 337 Query: 1406 PKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFL-TNRGVIHEFMGHKQNAMKD 1464 AV C + G + +N A++ + L NRG +G+ A D Sbjct: 338 ----------AVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFAEAD 387 Query: 1465 YQDAITLNP-------KYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA 1517 YQ A+ L+P + L G +QF +A ++FS A++ +P+ + RA Sbjct: 388 YQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRA 447 Query: 1518 ITNTILKKYEEAKEDFANVI 1537 + +L+ A++D A V+ Sbjct: 448 KSRQLLQNIFGARQDVATVL 467 Score = 50.1 bits (118), Expect = 2e-05 Identities = 48/186 (25%), Positives = 81/186 (43%), Gaps = 22/186 (11%) Query: 1273 FLNRGLIYVELGQYGFALEDF---------KQAALISRTNGSLC---HATAMCHHRINEF 1320 FL RG +Y L ++ A+EDF Q ++ + L + A+ +R + Sbjct: 288 FLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAY 347 Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380 +E V AL+ Y+ RG+ + + G+ A+ D+ +AL ++P A Sbjct: 348 QEGVLLLNKALRDEQQEKGLYINRGDCFFQLGN---LAFAEADYQQALALSPQDEGANTR 404 Query: 1381 FGYNLQAQG-------KFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433 G + G +FQKA NHF+ AI +P+ Y RA + N F A QD+ Sbjct: 405 MGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKSRQLLQNIFGARQDVA 464 Query: 1434 AAMKIS 1439 + ++ Sbjct: 465 TVLLLN 470 Score = 38.1 bits (87), Expect = 0.069 Identities = 45/204 (22%), Positives = 71/204 (34%), Gaps = 26/204 (12%) Query: 1372 PAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQD 1431 P ++ S G Q ++ A F+ A+ DP+ Y RA LQ+ + +A Q+ Sbjct: 58 PLKVREYYSRGQQCLEQADWETAVLLFSRALHLDPQLVDFYALRAEAYLQLCDFSSAAQN 117 Query: 1432 INAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQ 1491 + A + QD + + + G F Sbjct: 118 LRRAYSLQ--------------------------QDNCKHLERLTFVLYLQGQCLFEQCA 151 Query: 1492 FSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRA 1551 F A + FS A + PE LK+++ N ++ A VY RA Sbjct: 152 FLDALNVFSHAAELQPEKPCFRYRCMACLLALKQHQACLTLITNELKQDTTNADVYIFRA 211 Query: 1552 HFYYCLKQYELAEEDLNKALSLKP 1575 Y L++ L DL+ AL L P Sbjct: 212 RLYNFLQKPHLCYRDLHSALLLNP 235 Score = 36.6 bits (83), Expect = 0.20 Identities = 60/321 (18%), Positives = 113/321 (35%), Gaps = 46/321 (14%) Query: 1289 ALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSY 1348 AL F AA + + C + + + + T LK + D Y+ R Y Sbjct: 155 ALNVFSHAAELQPEKPCFRYRCMACLLALKQHQACLTLITNELKQDTTNADVYIFRARLY 214 Query: 1349 MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYN-------------LQAQGKFQKAW 1395 + +D AL +NP + +AR+ L QGK Q A Sbjct: 215 ---NFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQARQDAGILAVQGKLQHAL 271 Query: 1396 NHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFM 1455 AI+ +P + + L G + +Q+ + G + +F+ Sbjct: 272 QRINRAIENNPLDPSLF-------LFRGTMYRRLQEFD---------------GAVEDFL 309 Query: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHR-QFSQASDYFSKALKFDPENEYVLM 1514 +D +D + + L +N ++ + + + + +KAL+ + + + + + Sbjct: 310 KVLDMVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYI 369 Query: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFN----RAHFYYC---LKQYELAEEDL 1567 NR L A+ D+ + P + +C KQ++ AE Sbjct: 370 NRGDCFFQLGNLAFAEADYQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHF 429 Query: 1568 NKALSLKPNDALVYNFRAKVR 1588 + A+ P A Y +RAK R Sbjct: 430 STAIRHNPQKAQYYLYRAKSR 450 Score = 32.7 bits (73), Expect = 2.9 Identities = 36/152 (23%), Positives = 61/152 (40%), Gaps = 23/152 (15%) Query: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954 +K +++ + ++T E+ T A Y R +Y L K DL +LL P A Sbjct: 183 LKQHQACLTLITNELKQDTTN-ADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQA- 240 Query: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKS 1014 R L+ + +A D + +GK L +N +AI++ Sbjct: 241 --RMLLQKMVAQAQQARQDAGIL----------------AVQGKLQHALQRIN--RAIEN 280 Query: 1015 TPTDADIYFRRGEMYEITNKV-LAIDDFSKCI 1045 P D ++ RG MY + A++DF K + Sbjct: 281 NPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVL 312 >gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 2 [Homo sapiens] Length = 438 Score = 55.1 bits (131), Expect = 5e-07 Identities = 85/361 (23%), Positives = 138/361 (38%), Gaps = 57/361 (15%) Query: 1275 NRGLIYVELGQYGFALEDFKQAALI--SRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332 NR + LG++ AL D +Q+ + S G L CH + A F AL+ Sbjct: 11 NRAATLMMLGRFREALGDAQQSVRLDDSFVRGHL--REGKCHLSLGNAMAACRSFQRALE 68 Query: 1333 INPCFLDAY--VGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGK 1390 ++ A N+ MEY T ++DF K + + + + Sbjct: 69 LDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVV--------------FCMDRALE 114 Query: 1391 FQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGV 1450 F A + F I LA GR + ++ M ST A+ L RG+ Sbjct: 115 FAPACHRFKIL----KAECLAMLGRYPEAQSVASDILRMD--------STNADALYVRGL 162 Query: 1451 IHEFMGHKQNAMKDYQDAITLNP---KYSLAYFNA---------GNIYFHHRQFSQASDY 1498 + + A++ + A+ + P K +A NA GN F + A + Sbjct: 163 CLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYEL 222 Query: 1499 FSKALKFDPEN----EYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFY 1554 +++AL DP N + NR N+ L+K ++A ED N ++ + Y RA Y Sbjct: 223 YTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCY 282 Query: 1555 YCLKQYELAEEDLNKAL---SLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYA 1611 +QYE A D K K + L+ N ++ L + DY + L ++ A Sbjct: 283 MDTEQYEEAVRDYEKVYQTEKTKEHKQLLKN------AQLELKKSKRKDYYKILGVDKNA 336 Query: 1612 S 1612 S Sbjct: 337 S 337 Score = 46.2 bits (108), Expect = 3e-04 Identities = 73/312 (23%), Positives = 126/312 (40%), Gaps = 35/312 (11%) Query: 1016 PTDADIYFRRGEMYEITNKVL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIED 1074 P +A Y R + + A+ D + + D L+ G + N AA Sbjct: 3 PKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRS 62 Query: 1075 FTALLNIDHQNSQARGQYL---LMMKYYDLAKFTIYQ------IAEMDKGLSELSPMQQ- 1124 F L +DH+N+QA+ ++ +M+Y +A+ + + MD+ L E +P Sbjct: 63 FQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRAL-EFAPACHR 121 Query: 1125 ---------ALIYSFCENHDKAIEVLDGISWNRAEMTMCAL-LAKVQMKAKRTKEAVEVL 1174 A++ + E A ++L S N + + L L K + V+ L Sbjct: 122 FKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQAL 181 Query: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYI 1234 + A D +A A+ A G +EGN YKLA T A+ +D N+ Sbjct: 182 RMAPDHEKACIACRNAKALKAK--KEDGNKAFKEGN----YKLAYELYTEALGIDPNNIK 235 Query: 1235 A----FYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFAL 1290 + NR +K+R+L A+ D + LD T + +L R Y++ QY A+ Sbjct: 236 TNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDT---YIKAYLRRAQCYMDTEQYEEAV 292 Query: 1291 EDFKQAALISRT 1302 D+++ +T Sbjct: 293 RDYEKVYQTEKT 304 Score = 45.4 bits (106), Expect = 4e-04 Identities = 26/97 (26%), Positives = 44/97 (45%), Gaps = 3/97 (3%) Query: 898 YESEVKILTEEIN---DKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954 Y+ ++ TE + + K A YC RG + KL KL A+ D + L+ ++ AY Sbjct: 216 YKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAY 275 Query: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK 991 R Y+ ++ EA+ D +++ K L K Sbjct: 276 LRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLK 312 >gi|22749211 transmembrane and tetratricopeptide repeat containing 2 [Homo sapiens] Length = 836 Score = 55.1 bits (131), Expect = 5e-07 Identities = 73/289 (25%), Positives = 118/289 (40%), Gaps = 15/289 (5%) Query: 1195 ADCLYNLGLCYMEEGNLQMT---YKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251 AD LYNLGL E YKLAI T S N+ I N+ + R + Sbjct: 527 ADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRT-EEARRTFL 585 Query: 1252 ALTDYGIVLLLD--ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN---GSL 1306 ++ L D A ++ + N G +Y E G Y AL +K+A SL Sbjct: 586 KCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSL 645 Query: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366 + + R+++ EA +++ +L+ + A++ G G +A+K FLK Sbjct: 646 YNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGR---KSEAEKLFLK 702 Query: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426 A+ ++P + +G L + + +A A + D + A + Q N Sbjct: 703 AIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNE 762 Query: 1427 AAMQ--DINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473 AA + D+ A ++ + A L N G I G Q A +Y A+ L P Sbjct: 763 AAEKYYDLAARLRPNYPAA-LMNLGAILHLNGRLQKAEANYLRALQLKP 810 Score = 55.1 bits (131), Expect = 5e-07 Identities = 64/282 (22%), Positives = 109/282 (38%), Gaps = 28/282 (9%) Query: 1318 NEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK- 1376 + F EA++++ A+ P AY+ G M G T++A++ FLK I +K Sbjct: 541 SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGR---TEEARRTFLKCSEIPDENLKD 597 Query: 1377 ------ARISFGYNL----QAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426 + S YNL QG +++A + + AI P+ + + MG + Sbjct: 598 PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQS----LYNMMGEAY 653 Query: 1427 AAMQDINAA---------MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSL 1477 + + A K LT G + G K A K + AI L+P Sbjct: 654 MRLSKLPEAEHWYMESLRSKTDHIPAHLTY-GKLLALTGRKSEAEKLFLKAIELDPTKGN 712 Query: 1478 AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVI 1537 Y + G + +A++ KA + D V+ N A E A++ + Sbjct: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772 Query: 1538 ESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579 P + A N + + + AE + +AL LKP+D + Sbjct: 773 RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVI 814 Score = 42.0 bits (97), Expect = 0.005 Identities = 61/263 (23%), Positives = 102/263 (38%), Gaps = 30/263 (11%) Query: 1160 VQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISA-DCLYNLGLCYMEEGNLQ---MTY 1215 + M RT+EA K + + K P A S CLYNLG Y E+G+ + Y Sbjct: 570 ILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVY 629 Query: 1216 KLAITDLTTAISMDKNSYIAFYN-RALCYTKIRELQMALTDYGIVLLLDATETVKLNTFL 1274 K AI + + + YN Y ++ +L A Y L ++T + L Sbjct: 630 KEAIQKMPRQFAPQ-----SLYNMMGEAYMRLSKLPEAEHWYMESL---RSKTDHIPAHL 681 Query: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFF 1327 G + G+ A + F +A + T G+ C+ +F EA Sbjct: 682 TYGKLLALTGRKSEAEKLFLKAIELDPTKGN-------CYMHYGQFLLEEARLIEAAEMA 734 Query: 1328 TWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQA 1387 A +++ D + + +EA A+K + A + P Y A ++ G L Sbjct: 735 KKAAELDSTEFDVVFNAAHMLRQASLNEA---AEKYYDLAARLRPNYPAALMNLGAILHL 791 Query: 1388 QGKFQKAWNHFTIAIDTDPKNYL 1410 G+ QKA ++ A+ P + + Sbjct: 792 NGRLQKAEANYLRALQLKPDDVI 814 Score = 33.9 bits (76), Expect = 1.3 Identities = 61/267 (22%), Positives = 100/267 (37%), Gaps = 21/267 (7%) Query: 1359 QAQKDFLKALHINPAYIKARISFGYNLQA---QGKFQKAWNHFTIAIDTDPKNYLAYEGR 1415 + QK FLK+L Y A + Y L+ G +Q + I +P G Sbjct: 445 KVQKRFLKSLIF---YATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGN 501 Query: 1416 AVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKY 1475 V+ Q + A NA S A+ L N G++ + A+ Y+ AI P Sbjct: 502 -VLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTL 560 Query: 1476 SLAYFNAGNIYFHHRQFSQASDYFSKALKFDPEN--EYVLMNRAITNTILK--------- 1524 + AY N G I + + +A F K + EN + ++T+ + Sbjct: 561 ASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG 620 Query: 1525 KYEEAKEDFANVIESCPFWAA---VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581 YEEA + I+ P A +Y Y L + AE ++L K + + Sbjct: 621 HYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAH 680 Query: 1582 NFRAKVRGKIGLIEEAMADYNQALDLE 1608 K+ G EA + +A++L+ Sbjct: 681 LTYGKLLALTGRKSEAEKLFLKAIELD 707 >gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] Length = 1564 Score = 55.1 bits (131), Expect = 5e-07 Identities = 89/388 (22%), Positives = 155/388 (39%), Gaps = 37/388 (9%) Query: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY-KLAITDLTTAISMDKN-- 1231 KK DA+ + +G + + Y+L E ++M K A+ + A+ + N Sbjct: 286 KKYEDAVRNLTEGLKESPVCTSGWYHLA-----EAQVKMHRPKEAVLSCSQALKIVDNLG 340 Query: 1232 -SYIAFYNRALCYTKIRELQMALTDYG--------IVLLLDATETVKLNTFLNRGLIYVE 1282 S + Y R LC E + L+DY + + DA L + + L Y Sbjct: 341 ASGNSLYQRNLCLHLKAEALIKLSDYDSSEEAIRTLDQISDADNIPGL--LVLKSLAYRN 398 Query: 1283 LGQYGFALEDFKQAALISRTNGSLCHAT-AMCHHRINEFEEAVNFFTWALKINPCFLDAY 1341 G + A + + L S + + HA A+ H ++ +A F AL+ + + + Sbjct: 399 KGSFDEAAK-IMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYH 457 Query: 1342 VGRGNSYMEYGHD---EATKQAQKDFLKALHINPAYIKARISFGYNLQ--------AQGK 1390 G +Y G + + TK A FLKA ++ K G+ + A+G Sbjct: 458 YQLGLTYWFMGEETRKDKTK-ALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGC 516 Query: 1391 FQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGV 1450 ++KA+ DTD ++ A +V M A + + T RG+ Sbjct: 517 YRKAFE----LDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGL 572 Query: 1451 IHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENE 1510 + G A+ D Q A+ +PK + + G Y ++ A F+KA + +PE+ Sbjct: 573 YYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESI 632 Query: 1511 YVLMNRAITNTILKKYEEAKEDFANVIE 1538 Y + A IL KY+EA + +I+ Sbjct: 633 YSVFKVAAIQQILGKYKEAVAQYQMIIK 660 Score = 39.7 bits (91), Expect = 0.024 Identities = 100/521 (19%), Positives = 188/521 (36%), Gaps = 82/521 (15%) Query: 918 FAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYI 977 +A+ RRG Y K G+ A+ DLQ + +P N + YL + AL Sbjct: 565 WAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKA 624 Query: 978 HKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKVLA 1037 + N + + A I + A+ Y IK GE + + K Sbjct: 625 SELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAAL 684 Query: 1038 IDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMK 1097 +D + D K D + K A+E FT L Q R + K Sbjct: 685 VD------YLDGKAVDYIEK-------------ALEYFTCAL-------QHRADVSCLWK 718 Query: 1098 YYDLAKFTIYQIAEMDKGLSELSPM-----------QQALIYSFCENHDKAIEVLD---- 1142 A +Y +A + L + + L++ + +A++++ Sbjct: 719 LAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNT 778 Query: 1143 ----GISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCL 1198 GI++ R + + + + ++++ LKKA+ S++ +A + A Sbjct: 779 WCDLGINYYRQAQHLAETGSNMNDLKELLEKSLHCLKKAVRLDSNNHLYWNALGVVA--- 835 Query: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGI 1258 CY GN Y LA +I ++ + +A+ N + Y ++ A + + Sbjct: 836 -----CYSGIGN----YALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHEAFKM 886 Query: 1259 VLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRI 1317 LD + L ++ + LI +G Y ++ F+ L T G+L +A +C Sbjct: 887 AQSLDPS---YLMCWIGQALIAEAVGSYD-TMDLFRHTTELNMHTEGALGYAYWVCTTLQ 942 Query: 1318 NEFEEAVNFFTW------ALKINPCFLDAYVGRGNSYME--------YGHDEATKQAQKD 1363 ++ + + A+ L+ YV R +Y H + K+A Sbjct: 943 DKSNRETELYQYNILQMNAIPAAQVILNKYVERIQNYAPAFTMLGYLNEHLQLKKEAANA 1002 Query: 1364 FLKALHI------NPAYIKARISFGYNLQAQGKFQKAWNHF 1398 + +A+ + Y A ++G L + G++ KA F Sbjct: 1003 YQRAILLLQTAEDQDTYNVAIRNYGRLLCSTGEYDKAIQAF 1043 Score = 34.3 bits (77), Expect = 1.0 Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 3/137 (2%) Query: 1213 MTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNT 1272 M LAI T + + A+ R L Y K + A+ D L D + N Sbjct: 544 MEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKD---FNC 600 Query: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332 + + G Y+ G Y AL+ F +A+ ++ + A + +++EAV + +K Sbjct: 601 WESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIK 660 Query: 1333 INPCFLDAYVGRGNSYM 1349 ++ A G G ++ Sbjct: 661 KKEDYVPALKGLGECHL 677 >gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens] Length = 504 Score = 53.5 bits (127), Expect = 2e-06 Identities = 57/238 (23%), Positives = 100/238 (42%), Gaps = 22/238 (9%) Query: 1373 AYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDI 1432 A ++ + G L A G+ A + F A+D DP NY+AY RA V L MG + AA+ D+ Sbjct: 35 ADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDL 94 Query: 1433 NAA--MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHR 1490 +K+ TA L RG + G A D++ + NP Sbjct: 95 TKVIQLKMDFTAARL-QRGHLLLKQGKLDEAEDDFKKVLKSNPSE--------------- 138 Query: 1491 QFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNR 1550 ++ + S+ +K D L ++A+ Y A ++E C + A + R Sbjct: 139 --NEEKEAQSQLIKSDEMQR--LRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELR 194 Query: 1551 AHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 A + + A DL A LK ++ + + + ++G E ++++ + L L+ Sbjct: 195 AECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLD 252 Score = 49.7 bits (117), Expect = 2e-05 Identities = 45/195 (23%), Positives = 81/195 (41%), Gaps = 16/195 (8%) Query: 919 AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978 AY RR ++ +GK ++A+ DL +VI L+ F A R + L Q K++EA DD + Sbjct: 73 AYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVL 132 Query: 979 KYNKNNTEAYLSKAEIYR---------------GKKDITLAILNYTQAIKSTPTDADIYF 1023 K N + E +++++ + G D T AI + ++ DA++ Sbjct: 133 KSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRE 192 Query: 1024 RRGEMY-EITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNID 1082 R E + + AI D T+A K Y + + ++ + L +D Sbjct: 193 LRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLD 252 Query: 1083 HQNSQARGQYLLMMK 1097 + + Y + K Sbjct: 253 QDHKRCFAHYKQVKK 267 Score = 40.0 bits (92), Expect = 0.018 Identities = 58/318 (18%), Positives = 123/318 (38%), Gaps = 35/318 (11%) Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378 + +A++ F A+ +P AY R ++ G +A A D K + + + AR Sbjct: 52 QLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKA---ALPDLTKVIQLKMDFTAAR 108 Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYE---------------GRAVVCLQMG 1423 + G+ L QGK +A + F + ++P E +A+ G Sbjct: 109 LQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSG 168 Query: 1424 NNFAAMQDINAAMKIST-TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482 + AA+ ++ +++ AE R G + A+ D + A L + A++ Sbjct: 169 DYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKI 228 Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILK------------KYEEAK 1530 +Y+ + + LK D +++ + + K +Y +A Sbjct: 229 STLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDAT 288 Query: 1531 EDFANVIESCPFWAA-VYFNRAHFYYCLKQYELAEEDL---NKALSLKPNDALVYNFRAK 1586 + +V+++ P A ++ +C + E E + ++ L ++P++ RA+ Sbjct: 289 SKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAE 348 Query: 1587 VRGKIGLIEEAMADYNQA 1604 + +EA+ DY A Sbjct: 349 AYLIEEMYDEAIQDYETA 366 Score = 38.1 bits (87), Expect = 0.069 Identities = 65/345 (18%), Positives = 124/345 (35%), Gaps = 56/345 (16%) Query: 1218 AITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRG 1277 A++ A+ D ++YIA+Y RA + + + + AL D V+ L T L RG Sbjct: 56 ALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTA---ARLQRG 112 Query: 1278 LIYVELGQYGFALEDFK---------------QAALISRTNGSLCHATAMCHHRINEFEE 1322 + ++ G+ A +DFK Q+ LI + A+ ++ Sbjct: 113 HLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTA 172 Query: 1323 AVNFF-------TWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYI 1375 A+ F W ++ + ++ G +A + + D +A + Sbjct: 173 AIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFY------ 226 Query: 1376 KARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAA 1435 +IS Y + + + +D D K FA + + Sbjct: 227 --KISTLYYQLGDHELSLSEVRECLKLDQDHKRC----------------FAHYKQVKKL 268 Query: 1436 MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQD--AITLNPKYSLAYFNAGNIYFHHRQFS 1493 K+ +AE L G + ++ MK T+ K + + + + Sbjct: 269 NKLIESAEELIRDGRYTDATSKYESVMKTEPSIAEYTVRSKERICH-----CFSKDEKPV 323 Query: 1494 QASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIE 1538 +A S+ L+ +P+N L +RA I + Y+EA +D+ E Sbjct: 324 EAIRVCSEVLQMEPDNVNALKDRAEAYLIEEMYDEAIQDYETAQE 368 Score = 37.4 bits (85), Expect = 0.12 Identities = 43/195 (22%), Positives = 82/195 (42%), Gaps = 26/195 (13%) Query: 1180 AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNR 1239 AI+ DK + A+ C+++EG + AI+DL A + ++ AFY Sbjct: 173 AIAFLDKILEVCVWDAELRELRAECFIKEGEPRK----AISDLKAASKLKNDNTEAFYKI 228 Query: 1240 ALCYTKIRELQMALTDYGIVLLLDA---------TETVKLNTFLNRGLIYVELGQYGFAL 1290 + Y ++ + +++L++ L LD + KLN + + G+Y A Sbjct: 229 STLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDAT 288 Query: 1291 EDFKQ--------AALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342 ++ A R+ +CH C + + EA+ + L++ P ++A Sbjct: 289 SKYESVMKTEPSIAEYTVRSKERICH----CFSKDEKPVEAIRVCSEVLQMEPDNVNALK 344 Query: 1343 GRGNSYM-EYGHDEA 1356 R +Y+ E +DEA Sbjct: 345 DRAEAYLIEEMYDEA 359 Score = 32.7 bits (73), Expect = 2.9 Identities = 42/206 (20%), Positives = 84/206 (40%), Gaps = 28/206 (13%) Query: 931 GKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLS 990 G+L A++ + +P AY+ R ++L K AL DL + + + T A L Sbjct: 51 GQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQ 110 Query: 991 KAEIYRGKKDITLAILNYTQAIKSTPTDAD------IYFRRGEMYEITNKVL---AIDDF 1041 + + + + A ++ + +KS P++ + + EM + ++ L D+ Sbjct: 111 RGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDY 170 Query: 1042 SKCIFYDPKRTDAL--------LKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093 + I + K + L+ F E E AI D A + + N++A Sbjct: 171 TAAIAFLDKILEVCVWDAELRELRAECFIKEGEP-RKAISDLKAASKLKNDNTEA----- 224 Query: 1094 LMMKYYDLAKFTIYQIAEMDKGLSEL 1119 +Y ++ YQ+ + + LSE+ Sbjct: 225 ----FYKISTL-YYQLGDHELSLSEV 245 >gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) [Homo sapiens] Length = 543 Score = 52.8 bits (125), Expect = 3e-06 Identities = 50/228 (21%), Positives = 95/228 (41%), Gaps = 4/228 (1%) Query: 1350 EYGHDEATKQ----AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTD 1405 E G+D K+ A K + KA ++P + + +G + K AI+ Sbjct: 230 ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289 Query: 1406 PKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDY 1465 +N Y A ++GN++ + A+ + + + + +K+ Sbjct: 290 RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQ 349 Query: 1466 QDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525 + +NP +L N GN F + QA ++++A+K +P++ + NRA T L + Sbjct: 350 ERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409 Query: 1526 YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL 1573 ++ A +D I+ P + Y +A +K Y A + KAL L Sbjct: 410 FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDL 457 Score = 48.5 bits (114), Expect = 5e-05 Identities = 52/229 (22%), Positives = 95/229 (41%), Gaps = 41/229 (17%) Query: 1421 QMGNNFAAMQDINAAMKI--------STTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472 ++GN+ +D + A+K T ++TN+ ++ G + + AI + Sbjct: 230 ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289 Query: 1473 PK-------YSLAYFNAGNIYFHHRQFSQASDYFSKAL----------------KFDPEN 1509 + + AY GN YF ++ A +++K+L K E Sbjct: 290 RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQ 349 Query: 1510 E---YVLMNRAIT-----NTILKK--YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQ 1559 E Y+ + A+ N +K Y +A + + I+ P A +Y NRA Y L + Sbjct: 350 ERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409 Query: 1560 YELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 ++LA +D + + L+P Y +A + +AM Y +ALDL+ Sbjct: 410 FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458 Score = 40.8 bits (94), Expect = 0.011 Identities = 48/188 (25%), Positives = 79/188 (42%), Gaps = 14/188 (7%) Query: 917 AFAYCRRGAIYRKLGKLQSAMNDLQRVILLE--PLFLNAYWHRHLIYLFQDKINEALDDL 974 A AY R G Y K K + A++ + + P L I Q+++ DL Sbjct: 300 AKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDL 359 Query: 975 NYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITN 1033 K NK N E ++ K D A+ +YT+AIK P DA +Y R Y ++ Sbjct: 360 ALEEK-NKGN--------ECFQ-KGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409 Query: 1034 KVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQAR-GQY 1092 LA+ D +CI +P ++ +++ A++ + L++D +A G Sbjct: 410 FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQ 469 Query: 1093 LLMMKYYD 1100 MM Y+ Sbjct: 470 RCMMAQYN 477 Score = 40.4 bits (93), Expect = 0.014 Identities = 24/95 (25%), Positives = 40/95 (42%) Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542 GN A +S+A+K DP N + NR+ Y++A ED ++ P Sbjct: 11 GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70 Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPND 1577 W Y +A L ++E A+ + L + N+ Sbjct: 71 WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANN 105 Score = 37.4 bits (85), Expect = 0.12 Identities = 45/224 (20%), Positives = 85/224 (37%), Gaps = 39/224 (17%) Query: 1175 KKALD-AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLA-------------IT 1220 KK D A+ H DK + + + N Y E+G+ +L Sbjct: 238 KKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYR 297 Query: 1221 DLTTAISMDKNSY---------IAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLN 1271 + A + NSY I FYN++L + ++ + +L + +N Sbjct: 298 QIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDV-LKKCQQAEKILKEQERLAYIN 356 Query: 1272 TFL-----NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNF 1326 L N+G + G Y A++ + +A + + L A C+ ++ EF+ A+ Sbjct: 357 PDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKD 416 Query: 1327 FTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHI 1370 +++ P F+ Y + A +A KD+ KA+ + Sbjct: 417 CEECIQLEPTFIKGYTRKA----------AALEAMKDYTKAMDV 450 Score = 36.2 bits (82), Expect = 0.26 Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 1/57 (1%) Query: 898 YESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954 Y +K TE I K A Y R A Y KL + Q A+ D + I LEP F+ Y Sbjct: 376 YPQAMKHYTEAIKRNPK-DAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGY 431 Score = 33.9 bits (76), Expect = 1.3 Identities = 23/82 (28%), Positives = 38/82 (46%) Query: 1527 EEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAK 1586 ++A + ++ I+ P +Y NR+ Y Y+ A ED K + LKP+ Y+ +A Sbjct: 21 DDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAA 80 Query: 1587 VRGKIGLIEEAMADYNQALDLE 1608 + EEA Y + L E Sbjct: 81 ALEFLNRFEEAKRTYEEGLKHE 102 Score = 33.1 bits (74), Expect = 2.2 Identities = 19/79 (24%), Positives = 36/79 (45%) Query: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM 1514 +G+ +A++ Y +AI L+P + Y N Y + +A + K + P+ Sbjct: 17 VGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYS 76 Query: 1515 NRAITNTILKKYEEAKEDF 1533 +A L ++EEAK + Sbjct: 77 RKAAALEFLNRFEEAKRTY 95 >gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta [Homo sapiens] Length = 304 Score = 52.0 bits (123), Expect = 5e-06 Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 8/120 (6%) Query: 1414 GRAVVCLQMGNNFAAMQDINAAMKIST--------TAEFLTNRGVIHEFMGHKQNAMKDY 1465 G+A GNN ++ AA+ T A + NR +GH +A+KD Sbjct: 83 GKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDC 142 Query: 1466 QDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525 + AI ++ KYS AY G +F +A + KAL DPEN+ N I L++ Sbjct: 143 EKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLRE 202 Score = 47.0 bits (110), Expect = 1e-04 Identities = 44/159 (27%), Positives = 67/159 (42%), Gaps = 14/159 (8%) Query: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373 H + + AV+ +T A++++P Y R + + GH A KD KA+ I+ Sbjct: 95 HMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGH---YTDAIKDCEKAIAIDSK 151 Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQ----------MG 1423 Y KA G L A KF++A + A+D DP+N +Y+ + Q G Sbjct: 152 YSKAYGRMGLALTALNKFEEAVTSYQKALDLDPEND-SYKSNLKIAEQKLREVSSPTGTG 210 Query: 1424 NNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAM 1462 +F IN IS A + N V G NA+ Sbjct: 211 LSFDMASLINNPAFISMAASLMQNPQVQQLMSGMMTNAI 249 Score = 42.7 bits (99), Expect = 0.003 Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 1/103 (0%) Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542 GN + ++ A D +++A++ DP N NRA + L Y +A +D I Sbjct: 92 GNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSK 151 Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP-NDALVYNFR 1584 ++ Y L ++E A KAL L P ND+ N + Sbjct: 152 YSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLK 194 Score = 37.4 bits (85), Expect = 0.12 Identities = 37/164 (22%), Positives = 70/164 (42%), Gaps = 12/164 (7%) Query: 1179 DAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYN 1238 D + S+ P+ AD L + G +M+E N Y A+ T AI +D N+ + + N Sbjct: 70 DVLPLSNSVPEDVG-KADQLKDEGNNHMKEEN----YAAAVDCYTQAIELDPNNAVYYCN 124 Query: 1239 RALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAAL 1298 RA +K+ A+ D + +D+ + + GL L ++ A+ +++A Sbjct: 125 RAAAQSKLGHYTDAIKDCEKAIAIDSKYS---KAYGRMGLALTALNKFEEAVTSYQKALD 181 Query: 1299 ISRTNGSLCHATAMCHHRINEFEE----AVNFFTWALKINPCFL 1338 + N S + ++ E ++F +L NP F+ Sbjct: 182 LDPENDSYKSNLKIAEQKLREVSSPTGTGLSFDMASLINNPAFI 225 Score = 37.4 bits (85), Expect = 0.12 Identities = 25/85 (29%), Positives = 37/85 (43%) Query: 1524 KKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNF 1583 + Y A + + IE P A Y NRA L Y A +D KA+++ + Y Sbjct: 99 ENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGR 158 Query: 1584 RAKVRGKIGLIEEAMADYNQALDLE 1608 + EEA+ Y +ALDL+ Sbjct: 159 MGLALTALNKFEEAVTSYQKALDLD 183 Score = 36.6 bits (83), Expect = 0.20 Identities = 35/139 (25%), Positives = 58/139 (41%), Gaps = 7/139 (5%) Query: 860 KDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYESEVKILTEEINDKTKYPAFA 919 K+D + + PE V + +LK D + + +E Y + V T+ I + A Sbjct: 68 KNDVLPLSNSVPEDVGKADQLK--DEGNNHMKEE---NYAAAVDCYTQAI-ELDPNNAVY 121 Query: 920 YCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHK 979 YC R A KLG A+ D ++ I ++ + AY L +K EA+ Sbjct: 122 YCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALD 181 Query: 980 YNKNNTEAYLSKAEIYRGK 998 + N ++Y S +I K Sbjct: 182 LDPEN-DSYKSNLKIAEQK 199 >gi|225735595 RNA polymerase II associated protein 3 isoform 3 [Homo sapiens] Length = 506 Score = 51.6 bits (122), Expect = 6e-06 Identities = 53/221 (23%), Positives = 92/221 (41%), Gaps = 14/221 (6%) Query: 1402 IDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQN 1460 +D DP N + RA ++ A D N A+ ++ + + + RG + + Sbjct: 1 MDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEE 60 Query: 1461 AMKDYQDAITLNP----------KYSLAYFNAGNIYFHHRQFS-QASDYFSKALKFDPEN 1509 A KDY+ + L P K S A + N Y ++++ K ++ Sbjct: 61 AKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNK 120 Query: 1510 EYVLMNRAITNTILK--KYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDL 1567 + + + N K KYE A E + I + A + NRA Y +++YE AE+D Sbjct: 121 QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 180 Query: 1568 NKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608 +A+ L + + + R R +G + EA D+ L LE Sbjct: 181 TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLE 221 Score = 45.4 bits (106), Expect = 4e-04 Identities = 47/232 (20%), Positives = 94/232 (40%), Gaps = 20/232 (8%) Query: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419 A+ D A+ +N +Y KA G A K ++A + ++ +P Sbjct: 27 AESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP------------- 73 Query: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479 NNF A ++ KIS N + K + Q N + +++ Sbjct: 74 ----NNFEATNELR---KISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISE 126 Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539 + GN +F ++ +A + +++ + D N + NRA+ ++KYEEA++D I Sbjct: 127 KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILL 186 Query: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKI 1591 ++ + R L + A++D L L+P + +K++ ++ Sbjct: 187 DGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 238 Score = 38.9 bits (89), Expect = 0.041 Identities = 35/136 (25%), Positives = 57/136 (41%), Gaps = 22/136 (16%) Query: 1168 KEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAIS 1227 ++ +E + AIS D+G + +EG Y+ AI T I+ Sbjct: 111 RKQIEAQQNKQQAISEKDRGNG---------------FFKEGK----YERAIECYTRGIA 151 Query: 1228 MDKNSYIAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYG 1287 D + + NRA+ Y KI++ + A D +LLD + + F RG LG+ Sbjct: 152 ADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYS---KAFARRGTARTFLGKLN 208 Query: 1288 FALEDFKQAALISRTN 1303 A +DF+ L+ N Sbjct: 209 EAKQDFETVLLLEPGN 224 Score = 38.5 bits (88), Expect = 0.053 Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 35/220 (15%) Query: 919 AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978 AY RRGA L KL+ A D +RV+ LEP N + EA ++L I Sbjct: 44 AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 86 Query: 979 KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034 + + +Y +A+I G++ A N QAI S + +F+ G+ YE Sbjct: 87 QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 140 Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA---RGQ 1091 AI+ +++ I D R + Y + + + A +D T + +D S+A RG Sbjct: 141 -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 199 Query: 1092 YLLMMKYYDLAKFTIYQIAEMDKG----LSELSPMQQALI 1127 + + AK + ++ G ++ELS +++ LI Sbjct: 200 ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELI 239 Score = 34.7 bits (78), Expect = 0.77 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%) Query: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334 +RG + + G+Y A+E + + N L AM + +I ++EEA T A+ ++ Sbjct: 128 DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 187 Query: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372 + A+ RG + G +A++DF L + P Sbjct: 188 GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 222 Score = 34.3 bits (77), Expect = 1.0 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%) Query: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948 I+ YE K T+ I Y A+ RRG LGKL A D + V+LLEP Sbjct: 170 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 222 >gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens] Length = 313 Score = 48.1 bits (113), Expect = 7e-05 Identities = 30/107 (28%), Positives = 54/107 (50%), Gaps = 1/107 (0%) Query: 1420 LQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLA 1478 +++ N AA+ A++++ A + NR + +G+ A++D + AI ++P YS A Sbjct: 102 MKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKA 161 Query: 1479 YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525 Y G + +A Y+ KAL+ DP+NE N I L++ Sbjct: 162 YGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLRE 208 Score = 46.2 bits (108), Expect = 3e-04 Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 3/93 (3%) Query: 1316 RINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYI 1375 ++ FE AV+F+ A+++NP + R +Y + G+ Q D +A+ I+PAY Sbjct: 103 KVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQ---DCERAICIDPAYS 159 Query: 1376 KARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN 1408 KA G L + K +A ++ A++ DP N Sbjct: 160 KAYGRMGLALSSLNKHVEAVAYYKKALELDPDN 192 Score = 38.5 bits (88), Expect = 0.053 Identities = 42/160 (26%), Positives = 64/160 (40%), Gaps = 22/160 (13%) Query: 847 LIEYKDASIPVKEKDDKISVPEDPP---ERVKEPPKLKL--NDYVESDLPQEVIKYYESE 901 L E +A+ KE + P P E E +LK N+ ++ + + + +Y Sbjct: 58 LPEIFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKA 117 Query: 902 VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961 + E+N A +C R A Y KLG A+ D +R I ++P + AY L Sbjct: 118 I-----ELNPAN---AVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLAL 169 Query: 962 LFQDKINEA---------LDDLNYIHKYNKNNTEAYLSKA 992 +K EA LD N +K N E L +A Sbjct: 170 SSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLREA 209 Score = 38.1 bits (87), Expect = 0.069 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 3/91 (3%) Query: 1245 KIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNG 1304 K+ + A+ YG + L+ V F NR Y +LG Y A++D ++A I Sbjct: 103 KVENFEAAVHFYGKAIELNPANAVY---FCNRAAAYSKLGNYAGAVQDCERAICIDPAYS 159 Query: 1305 SLCHATAMCHHRINEFEEAVNFFTWALKINP 1335 + +N+ EAV ++ AL+++P Sbjct: 160 KAYGRMGLALSSLNKHVEAVAYYKKALELDP 190 Score = 35.4 bits (80), Expect = 0.45 Identities = 25/95 (26%), Positives = 38/95 (40%) Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542 GN F A ++ KA++ +P N NRA + L Y A +D I P Sbjct: 98 GNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPA 157 Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPND 1577 ++ Y L ++ A KAL L P++ Sbjct: 158 YSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDN 192 >gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens] Length = 151 Score = 47.0 bits (110), Expect = 1e-04 Identities = 34/110 (30%), Positives = 49/110 (44%), Gaps = 4/110 (3%) Query: 1427 AAMQDINAAMKISTT--AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGN 1484 AA D + K S A NRG I F AM DY AI + P + + Y+N G Sbjct: 41 AASSDESPGSKCSPEDLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGL 100 Query: 1485 IYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534 I + F A + F K L +P + + ++ TIL K E+ + + A Sbjct: 101 ILYRLGYFDDALEDFKKVLDLNPGFQDATL--SLKQTILDKEEKQRRNVA 148 Score = 37.7 bits (86), Expect = 0.091 Identities = 18/64 (28%), Positives = 32/64 (50%) Query: 1544 AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQ 1603 A Y NR Y + A +D A+ ++PN + Y R + ++G ++A+ D+ + Sbjct: 58 ATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKK 117 Query: 1604 ALDL 1607 LDL Sbjct: 118 VLDL 121 Score = 37.4 bits (85), Expect = 0.12 Identities = 20/64 (31%), Positives = 32/64 (50%) Query: 1478 AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVI 1537 AY N G I + F +A D ++ A++ P E NR + L +++A EDF V+ Sbjct: 60 AYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVL 119 Query: 1538 ESCP 1541 + P Sbjct: 120 DLNP 123 Score = 36.6 bits (83), Expect = 0.20 Identities = 26/82 (31%), Positives = 35/82 (42%), Gaps = 1/82 (1%) Query: 1495 ASDYFSKALKFDPEN-EYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHF 1553 AS S K PE+ NR + EA +D+ + IE P + Y+NR Sbjct: 42 ASSDESPGSKCSPEDLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLI 101 Query: 1554 YYCLKQYELAEEDLNKALSLKP 1575 Y L ++ A ED K L L P Sbjct: 102 LYRLGYFDDALEDFKKVLDLNP 123 Score = 34.7 bits (78), Expect = 0.77 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 3/62 (4%) Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378 +F EA++ +T A+++ P F Y RG G+ + A +DF K L +NP + A Sbjct: 73 DFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFD---DALEDFKKVLDLNPGFQDAT 129 Query: 1379 IS 1380 +S Sbjct: 130 LS 131 Score = 32.0 bits (71), Expect = 5.0 Identities = 24/84 (28%), Positives = 37/84 (44%) Query: 917 AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976 A AY RG I AM+D I ++P F Y++R LI ++AL+D Sbjct: 58 ATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKK 117 Query: 977 IHKYNKNNTEAYLSKAEIYRGKKD 1000 + N +A LS + K++ Sbjct: 118 VLDLNPGFQDATLSLKQTILDKEE 141 >gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo sapiens] Length = 833 Score = 46.6 bits (109), Expect = 2e-04 Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%) Query: 914 KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973 +Y A +G G + A + + + A ++ L Y ++++EALD Sbjct: 490 RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549 Query: 974 LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032 +H +N+ E A IY ++ + AI Q + PTD + + GE+Y+ Sbjct: 550 FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609 Query: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075 +K A + + Y P + + G +Y + + W AI+ F Sbjct: 610 DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652 Score = 42.7 bits (99), Expect = 0.003 Identities = 61/297 (20%), Positives = 110/297 (37%), Gaps = 22/297 (7%) Query: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DAISHSDK 1186 +KA+ L +N+A +L ++ K R K A AL A S++D Sbjct: 429 NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 484 Query: 1187 GPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKI 1246 ++ + L N G G+ Y+ A A+ D + A YN L Y K+ Sbjct: 485 AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540 Query: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306 L AL + L L A IY + A+E Q + T+ + Sbjct: 541 NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 597 Query: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366 + R + +A ++ + + PC ++ G Y++ + ++A + F + Sbjct: 598 LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 654 Query: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423 A I P +K ++ + G +QKA + + P+N +C +G Sbjct: 655 ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 711 Score = 42.0 bits (97), Expect = 0.005 Identities = 88/436 (20%), Positives = 160/436 (36%), Gaps = 80/436 (18%) Query: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGI 1258 Y++ Y E N TY++ + + M N+ I N Y K R A+ Y + Sbjct: 216 YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 267 Query: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316 L + + +++ N G+ +++ GQY A+ ++ ++ N + +C+ Sbjct: 268 ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 326 Query: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359 I + E+ F T L+I+ D Y+ N ++ E Sbjct: 327 IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 383 Query: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419 A+K + + + I+ + GY+ + KA + +A D + + Y Sbjct: 384 AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 434 Query: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479 +D N A++I E K + +K S A Sbjct: 435 -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 462 Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539 N +Y+ + F+QAS Y A+ D N L N+ T YE+A E + + + Sbjct: 463 TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 522 Query: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599 +N Y L + + A + K ++ N A+V +I I E M Sbjct: 523 DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 575 Query: 1600 DYNQALD-LEDYASVI 1614 + +QA++ L SVI Sbjct: 576 NPSQAIEWLMQVVSVI 591 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.133 0.385 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 59,723,188 Number of Sequences: 37866 Number of extensions: 2775223 Number of successful extensions: 11982 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 75 Number of HSP's successfully gapped in prelim test: 150 Number of HSP's that attempted gapping in prelim test: 10739 Number of HSP's gapped (non-prelim): 1052 length of query: 1614 length of database: 18,247,518 effective HSP length: 116 effective length of query: 1498 effective length of database: 13,855,062 effective search space: 20754882876 effective search space used: 20754882876 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.