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Search of human proteins with 10863903
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10863903 thyroid hormone receptor interactor 12 [Homo
sapiens]
(1992 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens] 3950 0.0
gi|118498337 HECT domain containing 1 [Homo sapiens] 179 3e-44
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 151 5e-36
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 151 5e-36
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 151 5e-36
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 144 9e-34
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 144 9e-34
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 139 4e-32
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 135 5e-31
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 127 1e-28
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 127 1e-28
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 126 2e-28
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 120 1e-26
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 115 3e-25
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 115 3e-25
gi|222352183 neural precursor cell expressed, developmentally do... 114 1e-24
gi|21361472 neural precursor cell expressed, developmentally dow... 114 1e-24
gi|222352094 neural precursor cell expressed, developmentally do... 114 1e-24
gi|222352092 neural precursor cell expressed, developmentally do... 114 1e-24
gi|222352090 neural precursor cell expressed, developmentally do... 114 1e-24
gi|222352088 neural precursor cell expressed, developmentally do... 114 1e-24
gi|222352086 neural precursor cell expressed, developmentally do... 114 1e-24
gi|222352084 neural precursor cell expressed, developmentally do... 114 1e-24
gi|222352082 neural precursor cell expressed, developmentally do... 114 1e-24
gi|114520609 neural precursor cell expressed, developmentally do... 112 5e-24
gi|114520607 neural precursor cell expressed, developmentally do... 112 5e-24
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 104 8e-22
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 103 1e-21
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 103 2e-21
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 103 2e-21
>gi|10863903 thyroid hormone receptor interactor 12 [Homo sapiens]
Length = 1992
Score = 3950 bits (10245), Expect = 0.0
Identities = 1992/1992 (100%), Positives = 1992/1992 (100%)
Query: 1 MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKT 60
MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKT
Sbjct: 1 MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKT 60
Query: 61 GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQ 120
GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQ
Sbjct: 61 GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKRHLDQEQ 120
Query: 121 QLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLAS 180
QLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLAS
Sbjct: 121 QLKSAQSPSTSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLAS 180
Query: 181 KSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSP 240
KSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSP
Sbjct: 181 KSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSP 240
Query: 241 SPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLA 300
SPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLA
Sbjct: 241 SPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLA 300
Query: 301 SLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPE 360
SLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPE
Sbjct: 301 SLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPE 360
Query: 361 SNQEAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLG 420
SNQEAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLG
Sbjct: 361 SNQEAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRLQALLEARGLPPHLFGPLG 420
Query: 421 PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKS 480
PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKS
Sbjct: 421 PRMSQLFHRTIGSGASSKAQQLLQGLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKS 480
Query: 481 VVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAE 540
VVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAE
Sbjct: 481 VVPALITLLQMEHNFDIMNHACRALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAE 540
Query: 541 QALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFV 600
QALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFV
Sbjct: 541 QALTALEMLSRRHSKAILQAGGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFV 600
Query: 601 ADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTP 660
ADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTP
Sbjct: 601 ADSLPLLTQRLTHQDKKSVESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTP 660
Query: 661 PILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRS 720
PILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRS
Sbjct: 661 PILSSGMFIMVVRMFSLMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRS 720
Query: 721 PQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDS 780
PQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDS
Sbjct: 721 PQELYELTSLICELMPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDS 780
Query: 781 RIIEQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFG 840
RIIEQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFG
Sbjct: 781 RIIEQINEDTGTARAIQRKPNPLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFG 840
Query: 841 VLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVV 900
VLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVV
Sbjct: 841 VLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIVV 900
Query: 901 GALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSV 960
GALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSV
Sbjct: 901 GALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSMGSTTSV 960
Query: 961 SSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRD 1020
SSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRD
Sbjct: 961 SSGTATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRD 1020
Query: 1021 DDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKD 1080
DDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKD
Sbjct: 1021 DDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSTQSNSNNIEPARTAGGSGLARAASKD 1080
Query: 1081 TISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAEC 1140
TISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAEC
Sbjct: 1081 TISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQVDGGAEC 1140
Query: 1141 LVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPG 1200
LVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPG
Sbjct: 1141 LVEIRSIVSESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPG 1200
Query: 1201 EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKF 1260
EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKF
Sbjct: 1201 EEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKF 1260
Query: 1261 FNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDD 1320
FNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDD
Sbjct: 1261 FNTHQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDD 1320
Query: 1321 GSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDE 1380
GSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDE
Sbjct: 1321 GSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQAVRQFSIQAEDERESTDDE 1380
Query: 1381 SNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHD 1440
SNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHD
Sbjct: 1381 SNPLGRAGIWTKTHTIWYKPVREDEESNKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHD 1440
Query: 1441 GVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPT 1500
GVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPT
Sbjct: 1441 GVCPSVSNPLEVYLIPTPPENITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPT 1500
Query: 1501 SEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDR 1560
SEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDR
Sbjct: 1501 SEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDR 1560
Query: 1561 AMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQY 1620
AMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQY
Sbjct: 1561 AMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQY 1620
Query: 1621 ENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALP 1680
ENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALP
Sbjct: 1621 ENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALP 1680
Query: 1681 FGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFD 1740
FGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFD
Sbjct: 1681 FGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFD 1740
Query: 1741 IDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFP 1800
IDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFP
Sbjct: 1741 IDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFP 1800
Query: 1801 NIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPE 1860
NIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPE
Sbjct: 1801 NIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPE 1860
Query: 1861 ELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTG 1920
ELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTG
Sbjct: 1861 ELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTG 1920
Query: 1921 SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLI 1980
SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLI
Sbjct: 1921 SPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLI 1980
Query: 1981 AAREGQQSFHLS 1992
AAREGQQSFHLS
Sbjct: 1981 AAREGQQSFHLS 1992
>gi|118498337 HECT domain containing 1 [Homo sapiens]
Length = 2610
Score = 179 bits (453), Expect = 3e-44
Identities = 99/273 (36%), Positives = 158/273 (57%), Gaps = 19/273 (6%)
Query: 1733 LTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNG-------C 1785
LT D ++P AR + ++D+ +++++ +K +++ L+ L +
Sbjct: 2344 LTWEDFELVNPHRARFLKEIKDLAIKRRQILSNKGLSEDEKNTKLQELVLKNPSGSGPPL 2403
Query: 1786 SVEDLGLDFT------LPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFD 1839
S+EDLGL+F + GF ++LK G+D +T+ N EEY+ L+ + ++ G+ +Q +
Sbjct: 2404 SIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQME 2463
Query: 1840 SFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFL 1899
+FRDGF VFP+ L F EE+ +LCG+++ +W A+ ++ P GYT DS
Sbjct: 2464 AFRDGFNKVFPMEKLSSFSHEEVQMILCGNQSPSWAAEDIINYTEPKLGYTRDSPGFLRF 2523
Query: 1900 FEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTC 1959
+L +++++ FLQF TG LP GG +L+P LT+VRK + D PSV TC
Sbjct: 2524 VRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTVVRK----VDATDASYPSVNTC 2579
Query: 1960 VNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS 1992
V+YLKLP+YSS EIMRE+LL A E + FHL+
Sbjct: 2580 VHYLKLPEYSSEEIMRERLLAATME--KGFHLN 2610
Score = 162 bits (410), Expect = 3e-39
Identities = 113/350 (32%), Positives = 173/350 (49%), Gaps = 42/350 (12%)
Query: 1470 DVILLLRVLHAISRYWYYLYDNAMCKEII----PTSEFINSKLTAKANRQLQDPLVIMTG 1525
DV+ LLR+L+ ++ Y E + P EF + K+T K +Q+++PL + +G
Sbjct: 1999 DVLQLLRILYIVASDPYSRISQEDGDEQLQFTFPPDEFTSKKITTKILQQIEEPLALASG 2058
Query: 1526 NIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLD----------TNPEINQS 1575
+P W +L CPF PF+TRQ+ F TAF RA+ L + T + +
Sbjct: 2059 ALPDWCEQLTSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSVRRD 2118
Query: 1576 DSQDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFY 1635
D + RV + + E L++ AE+VMQ +++LE+++ E GTGLGPTLEFY
Sbjct: 2119 DPGEFRVGRLKHERVKVPRGESLMEWAENVMQIHADRKSVLEVEFLGEEGTGLGPTLEFY 2178
Query: 1636 ALVSQELQRADLGLW---------RGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAK 1686
ALV+ E QR DLG W V L G + Y+Q GLF PF + +
Sbjct: 2179 ALVAAEFQRTDLGAWLCDDNFPDDESRHVDLGG--GLKPPGYYVQRSCGLFTAPFPQDSD 2236
Query: 1687 PAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVA 1746
+ ++ F FLG +AK I D RLVDLP+ PF+K M + DI ++
Sbjct: 2237 --ELERITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLMC----------MGDIKSNMS 2284
Query: 1747 RSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTL 1796
+ +Y R + L +SQ++ S + ++L++ G ED +F L
Sbjct: 2285 KLIYE----SRGDRDLHCTESQSEASTEEGHDSLSV-GSFEEDSKSEFIL 2329
Score = 65.9 bits (159), Expect = 4e-10
Identities = 55/208 (26%), Positives = 95/208 (45%), Gaps = 20/208 (9%)
Query: 443 LQGLQASDESQQLQAVIEMCQLLVMGN--EETLGGFPVKSVVPALITLLQMEHNFD-IMN 499
LQ Q + QL A+ ++C LL+M + + P ++ +PAL + E D ++
Sbjct: 13 LQMGQGDERDMQLIALEQLCMLLLMSDNVDRCFETCPPRTFLPALCKIFLDESAPDNVLE 72
Query: 500 HACRALTYMMEALPRSSAVVVD---AIPVFLEKLQVIQCI-----DVAEQALTALEMLSR 551
RA+TY ++ + +V AI +L V++ D+AEQ + LE++
Sbjct: 73 VTARAITYYLDVSAECTRRIVGVDGAIKALCNRLVVVELNNRTSRDLAEQCVKVLELICT 132
Query: 552 RHSKAILQAGGLADCLLYL----EFFSINAQRNALAIAANCCQSITPDE--FHFVADSLP 605
R S A+ +AGGL L ++ + +A+A+ + C + P + +SL
Sbjct: 133 RESGAVFEAGGLNCVLTFIRDSGHLVHKDTLHSAMAVVSRLCGKMEPQDSSLEICVESLS 192
Query: 606 LLTQRLTHQDKKSVESTCLCFARLVDNF 633
L L H+D + + CFA L D F
Sbjct: 193 SL---LKHEDHQVSDGALRCFASLADRF 217
Score = 52.4 bits (124), Expect = 4e-06
Identities = 40/154 (25%), Positives = 77/154 (50%), Gaps = 20/154 (12%)
Query: 1150 ESDVSSFEIQHSGFVKQLLLYLTSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPIGRVEP 1209
E+ +S +E+ SG V+ LL L + + D +L ++VF ++ E+ R
Sbjct: 903 ENTISPYEMCSSGLVQALLTVLNNSMDLDMKQDCSQLVERINVFKTAFSENEDDESR--- 959
Query: 1210 VGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGSFSLNRGSQALKFFNTHQLKCQ 1269
P +AL+ K+ L +E+ P+ ++D P G +++L T +L+ +
Sbjct: 960 ----PAVALIRKLIAVLESIERLPLHLYDTP-----GSTYNLQ--------ILTRRLRFR 1002
Query: 1270 LQRHPDCANVKQWKGGPVKIDPLALVQAIERYLV 1303
L+R P + G +K++PLA V+++E+YL+
Sbjct: 1003 LERAPGETALIDRTGRMLKMEPLATVESLEQYLL 1036
Score = 49.3 bits (116), Expect = 4e-05
Identities = 38/146 (26%), Positives = 67/146 (45%), Gaps = 10/146 (6%)
Query: 802 PLANSNTSGYSESKKDDARAQLMKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRA 861
P+ + ++ KD+ K DPE+A ++K L V + + + P++R L
Sbjct: 488 PVNKGDDKKKKDTNKDEEECNEPKGDPEMAPIYLKRLLPVFAQTFQQTMLPSIRKASLAL 547
Query: 862 ILRIIYFADAELLKDVLKNHAVSSHIASMLSSQDLKIV---------VGALQMAEILMQK 912
I ++I+F LLK+V + V ++ ++L ++ + ALQ+ L+ K
Sbjct: 548 IRKMIHFCSEALLKEVCDSD-VGHNLPTILVEITATVLDQEDDDDGHLLALQIIRDLVDK 606
Query: 913 LPDIFSVYFRREGVMHQVKHLAESES 938
DIF R GV+ +V LA S
Sbjct: 607 GGDIFLDQLARLGVISKVSTLAGPSS 632
Score = 40.8 bits (94), Expect = 0.013
Identities = 65/286 (22%), Positives = 117/286 (40%), Gaps = 30/286 (10%)
Query: 21 AGAQPQDDSIGGRSCSSSSAVIVPQPEDPDRANTSERQKTGQVPKKDNSRGV-KRSASPD 79
A +P ++ G + S SS V + PD+ + + G +K +S V ++S D
Sbjct: 1344 ASPKPVSSTVSGTTQSWSSLV---KNNCPDKTSAA----AGSSSRKGSSSSVCSVASSSD 1396
Query: 80 YNRTNSPSSAKKPKALQHT-ESPSETNKPHSKSKKRHLDQEQQLKSAQSPSTSKAHTRKS 138
+ ++ + + ++H+ S ++ ++P + ++ S+ S STS T ++
Sbjct: 1397 ISLGSTKTERRSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTL-TAET 1455
Query: 139 GATGGSR-----SQKRKRTESSCVKSG----------SGSESTGAEERSAKPTKLASKSA 183
G+ R S R ESS + G S SE T E S +P ++ +
Sbjct: 1456 GSENAERKLGPDSSVRTPGESSAISMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNR 1515
Query: 184 TSAKAGCSTITDSSSAAS-TSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSP 242
S + + SS+AS + SS +S S V A + + N SRS+S +
Sbjct: 1516 LSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRSSSDNNT 1575
Query: 243 RRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETS 288
R + T A+ P ++ P T ++ S+ S TS
Sbjct: 1576 NTLGRNVMSTATSPL----MGAQSFPNLTTPGTTSTVTMSTSSVTS 1617
Score = 32.0 bits (71), Expect = 6.2
Identities = 52/219 (23%), Positives = 87/219 (39%), Gaps = 38/219 (17%)
Query: 184 TSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSPR 243
TSA AG SSS +SSS +VAS+S S+ + R
Sbjct: 1372 TSAAAG------SSSRKGSSSSVCSVASSSDI-------------------SLGSTKTER 1406
Query: 244 RSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLASLR 303
RS E S G+ + S ++P+T++ S+ + T A+ R
Sbjct: 1407 RSEIVMEHSIVSGADVHEPIVVLSSAENVPQTEVGSSSSASTSTLTAETGSENAE----R 1462
Query: 304 KSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPESNQ 363
K S P E ++ + G + +S S + + EA Q ++ SN+
Sbjct: 1463 KLGPDSSVRTPGESSAI-------SMGIVSVSSPDVSSVSELTNKEAASQRPLSSSASNR 1515
Query: 364 EAVNSSAARTDEAPQGAAGAVGMTTSGESESDDSEMGRL 402
+V+S A AP ++ +V +S E+ S +S + R+
Sbjct: 1516 LSVSSLLAA--GAPMSSSASVPNLSSRETSSLESFVRRV 1552
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 151 bits (382), Expect = 5e-36
Identities = 144/494 (29%), Positives = 225/494 (45%), Gaps = 76/494 (15%)
Query: 1495 KEIIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVT 1554
K +IP EFIN L N L+ + T TCPF T+ + Y
Sbjct: 438 KPLIPFEEFINEPL----NEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYY- 492
Query: 1555 AFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRT--VNREELLKQAESVMQDLGSS 1612
D ++ + + S Q ++ P L K R + + L++ M++
Sbjct: 493 ----DNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 548
Query: 1613 RAMLEIQYENEVGTGLGP-TLEFYALVSQELQRADLGLWRGEEVTLS---NPKGSQEGTK 1668
+ L +++E E G G + EF+ LV +E+ D+G++ +E T NP +
Sbjct: 549 KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFET--- 605
Query: 1669 YIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLR 1728
+G F L +G ++ AI + ++D+ + Y+ ++
Sbjct: 606 -----EGQFTL--------------------IGIVLGLAIYNNCILDVHFPMVVYRKLMG 640
Query: 1729 QETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVE 1788
++ T DL D PV+ +S L+D++ + +E D T + Q L M
Sbjct: 641 KKG--TFRDLGDSHPVLYQS---LKDLLEYEGNVEDDMMITFQISQTDLFGNPMM----- 690
Query: 1789 DLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESV 1848
+LK+ G IP+T N +E++ L + LN+ V +QF +FR GF V
Sbjct: 691 -------------YDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMV 737
Query: 1849 FPLSHLQY-FYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFD 1907
S L+Y F PEE++ L+CGS+ D + L E D GYT DS ++ +EI+ SF
Sbjct: 738 TNESPLKYLFRPEEIELLICGSR--NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFT 795
Query: 1908 NEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPD 1967
+EQ+RLFLQF TG+ R PVGG L I+ K TE LP+ TC N L LP+
Sbjct: 796 DEQKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDTER----LPTSHTCFNVLLLPE 848
Query: 1968 YSSIEIMREKLLIA 1981
YSS E ++E+LL A
Sbjct: 849 YSSKEKLKERLLKA 862
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 151 bits (382), Expect = 5e-36
Identities = 144/494 (29%), Positives = 225/494 (45%), Gaps = 76/494 (15%)
Query: 1495 KEIIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVT 1554
K +IP EFIN L N L+ + T TCPF T+ + Y
Sbjct: 418 KPLIPFEEFINEPL----NEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYY- 472
Query: 1555 AFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRT--VNREELLKQAESVMQDLGSS 1612
D ++ + + S Q ++ P L K R + + L++ M++
Sbjct: 473 ----DNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 528
Query: 1613 RAMLEIQYENEVGTGLGP-TLEFYALVSQELQRADLGLWRGEEVTLS---NPKGSQEGTK 1668
+ L +++E E G G + EF+ LV +E+ D+G++ +E T NP +
Sbjct: 529 KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFET--- 585
Query: 1669 YIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLR 1728
+G F L +G ++ AI + ++D+ + Y+ ++
Sbjct: 586 -----EGQFTL--------------------IGIVLGLAIYNNCILDVHFPMVVYRKLMG 620
Query: 1729 QETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVE 1788
++ T DL D PV+ +S L+D++ + +E D T + Q L M
Sbjct: 621 KKG--TFRDLGDSHPVLYQS---LKDLLEYEGNVEDDMMITFQISQTDLFGNPMM----- 670
Query: 1789 DLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESV 1848
+LK+ G IP+T N +E++ L + LN+ V +QF +FR GF V
Sbjct: 671 -------------YDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMV 717
Query: 1849 FPLSHLQY-FYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFD 1907
S L+Y F PEE++ L+CGS+ D + L E D GYT DS ++ +EI+ SF
Sbjct: 718 TNESPLKYLFRPEEIELLICGSR--NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFT 775
Query: 1908 NEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPD 1967
+EQ+RLFLQF TG+ R PVGG L I+ K TE LP+ TC N L LP+
Sbjct: 776 DEQKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDTER----LPTSHTCFNVLLLPE 828
Query: 1968 YSSIEIMREKLLIA 1981
YSS E ++E+LL A
Sbjct: 829 YSSKEKLKERLLKA 842
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 151 bits (382), Expect = 5e-36
Identities = 144/494 (29%), Positives = 225/494 (45%), Gaps = 76/494 (15%)
Query: 1495 KEIIPTSEFINSKLTAKANRQLQDPLVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVT 1554
K +IP EFIN L N L+ + T TCPF T+ + Y
Sbjct: 441 KPLIPFEEFINEPL----NEVLEMDKDYTFFKVETENKFSFMTCPFILNAVTKNLGLYY- 495
Query: 1555 AFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRT--VNREELLKQAESVMQDLGSS 1612
D ++ + + S Q ++ P L K R + + L++ M++
Sbjct: 496 ----DNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHIIDDALVRLEMIAMENPADL 551
Query: 1613 RAMLEIQYENEVGTGLGP-TLEFYALVSQELQRADLGLWRGEEVTLS---NPKGSQEGTK 1668
+ L +++E E G G + EF+ LV +E+ D+G++ +E T NP +
Sbjct: 552 KKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPSSFET--- 608
Query: 1669 YIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLR 1728
+G F L +G ++ AI + ++D+ + Y+ ++
Sbjct: 609 -----EGQFTL--------------------IGIVLGLAIYNNCILDVHFPMVVYRKLMG 643
Query: 1729 QETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVE 1788
++ T DL D PV+ +S L+D++ + +E D T + Q L M
Sbjct: 644 KKG--TFRDLGDSHPVLYQS---LKDLLEYEGNVEDDMMITFQISQTDLFGNPMM----- 693
Query: 1789 DLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESV 1848
+LK+ G IP+T N +E++ L + LN+ V +QF +FR GF V
Sbjct: 694 -------------YDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMV 740
Query: 1849 FPLSHLQY-FYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFD 1907
S L+Y F PEE++ L+CGS+ D + L E D GYT DS ++ +EI+ SF
Sbjct: 741 TNESPLKYLFRPEEIELLICGSR--NLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFT 798
Query: 1908 NEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPD 1967
+EQ+RLFLQF TG+ R PVGG L I+ K TE LP+ TC N L LP+
Sbjct: 799 DEQKRLFLQFTTGTDRAPVGGLGKLK---MIIAKNGPDTER----LPTSHTCFNVLLLPE 851
Query: 1968 YSSIEIMREKLLIA 1981
YSS E ++E+LL A
Sbjct: 852 YSSKEKLKERLLKA 865
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 144 bits (363), Expect = 9e-34
Identities = 102/295 (34%), Positives = 145/295 (49%), Gaps = 43/295 (14%)
Query: 1697 FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIV 1756
FRF+G+ +A A+ + +D LPFYK ML + +L DL IDP S+ +++
Sbjct: 166 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK--DLESIDPEFYNSIVWIKENN 223
Query: 1757 RQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIH 1816
++ LE Q E L +T + ELK+GG+ I VT
Sbjct: 224 LEECGLELYFIQDME----ILGKVTTH-------------------ELKEGGESIRVTEE 260
Query: 1817 NLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSK---ADT 1873
N EEY+ L+ W GV Q +F DGF V PL L+YF +EL+ +LCG +
Sbjct: 261 NKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSD 320
Query: 1874 WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL- 1932
W T+ YT +S+ +++ ++++ DNE++ LQFVTG+ RLPVGGF L
Sbjct: 321 WQKSTIY------RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELI 374
Query: 1933 ---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 1984
P + K + T +LP TC N L LP Y S E +REKLL A E
Sbjct: 375 GSNGPQKFCIDKVGKET-----WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEE 424
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 144 bits (363), Expect = 9e-34
Identities = 102/295 (34%), Positives = 145/295 (49%), Gaps = 43/295 (14%)
Query: 1697 FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIV 1756
FRF+G+ +A A+ + +D LPFYK ML + +L DL IDP S+ +++
Sbjct: 605 FRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLK--DLESIDPEFYNSIVWIKENN 662
Query: 1757 RQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIH 1816
++ LE Q E L +T + ELK+GG+ I VT
Sbjct: 663 LEECGLELYFIQDME----ILGKVTTH-------------------ELKEGGESIRVTEE 699
Query: 1817 NLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSK---ADT 1873
N EEY+ L+ W GV Q +F DGF V PL L+YF +EL+ +LCG +
Sbjct: 700 NKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSD 759
Query: 1874 WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL- 1932
W T+ YT +S+ +++ ++++ DNE++ LQFVTG+ RLPVGGF L
Sbjct: 760 WQKSTIY------RHYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELI 813
Query: 1933 ---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 1984
P + K + T +LP TC N L LP Y S E +REKLL A E
Sbjct: 814 GSNGPQKFCIDKVGKET-----WLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEE 863
Score = 35.8 bits (81), Expect = 0.43
Identities = 40/155 (25%), Positives = 62/155 (40%), Gaps = 19/155 (12%)
Query: 116 LDQEQQLKSAQSPSTSKA----HTRKSGATGGSRSQKRKRTESSC-VKSGSGSESTGAEE 170
L QL S S T+ A H S G RS+ + + +S +G +S GA
Sbjct: 157 LTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGARS 216
Query: 171 RSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNK 230
R +P K + S + T+ D + A+ S V S PP A + + N
Sbjct: 217 RHRQPVKNSGHSGLAN----GTVNDEPTTATDPEEPSVVGVTS---PPAAPLSVTPNPN- 268
Query: 231 ARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAAR 265
+ S P+P + E E+ T G+ + AA+
Sbjct: 269 -----TTSLPAP-ATPAEGEEPSTSGTQQLPAAAQ 297
Score = 33.5 bits (75), Expect = 2.1
Identities = 22/74 (29%), Positives = 31/74 (41%), Gaps = 6/74 (8%)
Query: 191 STITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQN------KARRSRSASSPSPRR 244
S +TD S S SS +AVA + PP G+ + AR + + SP
Sbjct: 155 SALTDGSQLPSRDSSGTAVAPENRHQPPSTNCFGGRSRTHRHSGASARTTPATGEQSPGA 214
Query: 245 SSREKEQSKTGGSS 258
SR ++ K G S
Sbjct: 215 RSRHRQPVKNSGHS 228
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 139 bits (349), Expect = 4e-32
Identities = 97/294 (32%), Positives = 141/294 (47%), Gaps = 41/294 (13%)
Query: 1697 FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIV 1756
FRF+G+ +A A+ + +D LPFYK +L + L DL IDP S+ +++
Sbjct: 597 FRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLK--DLESIDPEFYNSLIWVKENN 654
Query: 1757 RQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIH 1816
++ LE S KE L + +LK G +I VT
Sbjct: 655 IEECDLEMYFSVDKE-----------------------ILGEIKSHDLKPNGGNILVTEE 691
Query: 1817 NLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSK---ADT 1873
N EEY+R+V W L+ GV Q +F +GF + P +LQYF +EL+ LLCG + +
Sbjct: 692 NKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLND 751
Query: 1874 WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL- 1932
W + Y S+ + + ++ + DNE++ LQFVTG+ RLPVGGF L
Sbjct: 752 WQRHAIY------RHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFADLM 805
Query: 1933 --NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 1984
N P +K +++LP TC N L LP Y S E ++EKLL A E
Sbjct: 806 GSNGP----QKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEE 855
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 135 bits (339), Expect = 5e-31
Identities = 104/308 (33%), Positives = 145/308 (47%), Gaps = 47/308 (15%)
Query: 1684 TAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDP 1743
T P H++ F F+G+ +A A+ + +D LPFYK ML ++ LT DL ID
Sbjct: 648 TINPDHLSY----FCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKK--LTIKDLESIDT 701
Query: 1744 VVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIE 1803
S+ + D ++ LE S E L + +
Sbjct: 702 EFYNSLIWIRDNNIEECGLEMYFSVDME-----------------------ILGKVTSHD 738
Query: 1804 LKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELD 1863
LK GG +I VT N +EY+ L+ W + GV Q +F DGF V PL LQYF +EL+
Sbjct: 739 LKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELE 798
Query: 1864 QLLCGSK----ADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVT 1919
+LCG + AD W T+ YT +S+ + + ++ + DNE + LQFVT
Sbjct: 799 VMLCGMQEVDLAD-WQRNTVY------RHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVT 851
Query: 1920 GSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMRE 1976
G+ RLP+GGF L N P +K D +LP TC N L LP Y S E ++E
Sbjct: 852 GTCRLPLGGFAELMGSNGP----QKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKE 907
Query: 1977 KLLIAARE 1984
KLL A E
Sbjct: 908 KLLFAIEE 915
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 127 bits (318), Expect = 1e-28
Identities = 111/384 (28%), Positives = 169/384 (44%), Gaps = 62/384 (16%)
Query: 1616 LEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWR---GEEVTLS-NPKGSQEGTKYI 1670
L I +E E G G L E+Y ++S+E+ L+R G+ VT + NP
Sbjct: 4046 LYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH------- 4098
Query: 1671 QNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQE 1730
P H++ F+F+G+++AKA+ D RL++ FYK +L +
Sbjct: 4099 --------------CNPNHLSY----FKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS 4140
Query: 1731 TSLTSHDLFDIDPVVARSVYHL-EDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVED 1789
T + D YH + +V LE D S L ++ E C V D
Sbjct: 4141 VRYTDMESED---------YHFYQGLVYL---LENDVSTLGYDLTFSTEVQEFGVCEVRD 4188
Query: 1790 LGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVF 1849
L K G +I VT N +EY+ LV + + +Q +F +GF +
Sbjct: 4189 L--------------KPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEII 4234
Query: 1850 PLSHLQYFYPEELDQLLCGSKA-DTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
P + F +EL+ L+ G D D K+ E H Y +S +++ + L SFD
Sbjct: 4235 PKRLISIFTEQELELLISGLPTIDIDDLKSNTEY----HKYQSNSIQIQWFWRALRSFDQ 4290
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDY 1968
+ FLQFVTG+ ++P+ GF +L I + + D LPS TC N L LP Y
Sbjct: 4291 ADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAY 4350
Query: 1969 SSIEIMREKLLIAAREGQQSFHLS 1992
S E +R LL+A +E + F L+
Sbjct: 4351 ESFEKLRHMLLLAIQECSEGFGLA 4374
Score = 37.0 bits (84), Expect = 0.19
Identities = 75/341 (21%), Positives = 116/341 (34%), Gaps = 50/341 (14%)
Query: 61 GQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPKALQHTESPSETNKPHSKSKKR--HLDQ 118
G+ K++ + + +AS + T S P + +PS T+ S+SK+ L
Sbjct: 2708 GKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTLQS 2767
Query: 119 EQQLKSAQSPSTS---KAHTRKSGATGGSRSQKRKRTESSCV--KSGSGSESTGAEERSA 173
QQ + +P + GGS +Q E + SG T E S
Sbjct: 2768 SQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQMELSP 2827
Query: 174 KPTKLA---------------------SKSATSAKAGCST--ITDSSSAASTSSSSSAVA 210
PT + S TS+ A C+ +SAA +S A +
Sbjct: 2828 APTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAGS 2887
Query: 211 SASSTVPPGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKV 270
S PP QG+ ++ SP SS SS D A S
Sbjct: 2888 STPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSE--------SSSTRDSAVAISGAD 2939
Query: 271 SLPKTKLSLPGSSKSETSKPG----PSGLQAK-LASLRKSTKKRSESPPAELPSLRRSTR 325
S + LP +S E P G+ LA+L ++ E+ + R
Sbjct: 2940 SRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIRR-------EVLQNQLGIR 2992
Query: 326 QKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPESNQEAV 366
T + ++ S + +G G E + A P + QE V
Sbjct: 2993 PPTRTAPSTNSSAPAVVGNPGVTEVSPEFLAALPPAIQEEV 3033
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 127 bits (318), Expect = 1e-28
Identities = 101/402 (25%), Positives = 178/402 (44%), Gaps = 51/402 (12%)
Query: 1593 VNREELLKQAESVMQDLGSSRAM--LEIQYENEVGTGLGPTLEFYALVSQELQRADLGLW 1650
V+R+ + + + V+ ++ + +++ E G G G E++ ++S E+ D L+
Sbjct: 557 VHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALF 616
Query: 1651 RGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMD 1710
S +GT + N P H+ FRF G+++ A+
Sbjct: 617 TQ----------SADGTTFQPNSNSY--------VNPDHLNY----FRFAGQILGLALNH 654
Query: 1711 FRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTK 1770
+LV++ FYK +L + D+ IDP A+++ + L+ D S
Sbjct: 655 RQLVNIYFTRSFYKHILG--IPVNYQDVASIDPEYAKNLQWI---------LDNDISDLG 703
Query: 1771 ESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWAL 1830
L +++ET + LK GG I VT +N EY++LV +
Sbjct: 704 LELTFSVETDVFGAME--------------EVPLKPGGGSILVTQNNKAEYVQLVTELRM 749
Query: 1831 NEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYT 1890
+ Q ++F GF P S +Q F EL+ LL G D ++ GY
Sbjct: 750 TRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI--DVSDWIKNTEYTSGYE 807
Query: 1891 HDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPD 1950
+ +++ +E++ E++ L LQFVTGS R+P GGF ++ + T +
Sbjct: 808 REDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTP 867
Query: 1951 DFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS 1992
+ LP+ TC+N LKLP+Y S EI++++LL+A G + ++
Sbjct: 868 NLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 909
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 126 bits (317), Expect = 2e-28
Identities = 118/421 (28%), Positives = 184/421 (43%), Gaps = 79/421 (18%)
Query: 1580 SRVAPRLDRKKRTVNREELLKQAESVMQDLGSS----RAMLEIQYENEVGTGLGPTLEFY 1635
S+ P+ + V+REE+ +++ + + R M++ + E + G G E+
Sbjct: 384 SQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYG-GVAREWL 442
Query: 1636 ALVSQELQRADLGLW---RGEEVTLS-NPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIA 1691
L+S E+ GL+ R + TL NP + P H++
Sbjct: 443 YLLSHEMLNPYYGLFQYSRDDIYTLQINPDSA---------------------VNPEHLS 481
Query: 1692 KVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYH 1751
F F+G++M A+ +D LPFYK +L + S+T D+ +DP + S+
Sbjct: 482 Y----FHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGK--SITLDDMELVDPDLHNSLVW 535
Query: 1752 LEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPG-FPNIELKKGGKD 1810
+ LE D + G ++ G ELK GK
Sbjct: 536 I---------LEND----------------ITGVLDHTFCVEHNAYGEIIQHELKPNGKS 570
Query: 1811 IPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCG-S 1869
IPV N +EY+RL + W G+ QF + + GF V P L+ F +EL+ ++CG
Sbjct: 571 IPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLG 630
Query: 1870 KADT--WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVG 1927
K D W T ++ C P DS VK+ ++ + FD E++ LQFVTGS R+P+
Sbjct: 631 KIDVNDWKVNTRLKHCTP------DSNIVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQ 684
Query: 1928 GFRSL----NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAR 1983
GF++L P L + + T N LP TC N + +P Y S E + EKLL A
Sbjct: 685 GFKALQGAAGPRLFTIHQIDACTNN----LPKAHTCFNRIDIPPYESYEKLYEKLLTAIE 740
Query: 1984 E 1984
E
Sbjct: 741 E 741
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 120 bits (301), Expect = 1e-26
Identities = 92/301 (30%), Positives = 141/301 (46%), Gaps = 40/301 (13%)
Query: 1697 FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIV 1756
+ FLG+++ KA+ + LV+LP F +L + H L +DP V +++ L
Sbjct: 818 YYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFL---- 873
Query: 1757 RQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFT-----LPGFPNIELKKGGKDI 1811
K E D VE+LGL+FT L +ELK GGKDI
Sbjct: 874 ---KSYEDD---------------------VEELGLNFTVVNNDLGEAQVVELKFGGKDI 909
Query: 1812 PVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKA 1871
PVT N Y+ LV + LN + + +FR G +V L L+ F +E+ L+ G++
Sbjct: 910 PVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQV 969
Query: 1872 DTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRS 1931
+ L GY+ D +K + ++ F +E++R L+FVT R P+ GF+
Sbjct: 970 PI-SLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKE 1028
Query: 1932 LNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQQSFHL 1991
L P I + + + LP+ TC+N LKLP++ ++R KLL A E F L
Sbjct: 1029 LYPAFCI-----HNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAI-ECAAGFEL 1082
Query: 1992 S 1992
S
Sbjct: 1083 S 1083
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 115 bits (289), Expect = 3e-25
Identities = 109/414 (26%), Positives = 184/414 (44%), Gaps = 70/414 (16%)
Query: 1584 PRLDRKKRTVNREELLKQAESVMQDLGSS--RAMLEIQYENEVGTGLGPTL-EFYALVSQ 1640
P+ + V+REE+ +++ + + + L +++ E G G E+ L+
Sbjct: 394 PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCH 453
Query: 1641 ELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFL 1700
E+ GL+ Q T I LQ + + P H++ F F+
Sbjct: 454 EMLNPYYGLF-------------QYSTDNIYMLQ----INPDSSINPDHLSY----FHFV 492
Query: 1701 GKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKK 1760
G++M A+ ++ +PFYK +L + L+ DL +DP + +S+ +
Sbjct: 493 GRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLS--DLESVDPELHKSLVWI-------- 542
Query: 1761 RLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEE 1820
LE D + + + VE L ELK G+++PVT N +E
Sbjct: 543 -LENDITPVLD-----------HTFCVEHNAFGRILQH----ELKPNGRNVPVTEENKKE 586
Query: 1821 YLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCG-SKAD--TWDAK 1877
Y+RL + W G+ QF + + GF + P L+ F +EL+ ++ G K D W +
Sbjct: 587 YVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSN 646
Query: 1878 TLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL----- 1932
T ++ C DS V++ ++ + +FD E++ LQFVTGS R+P+ GF++L
Sbjct: 647 TRLKHC------VADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTG 700
Query: 1933 --NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 1984
P L + +T+N LP TC N + +P Y S E + EKLL A E
Sbjct: 701 AAGPRLFTIHLIDANTDN----LPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 750
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 115 bits (289), Expect = 3e-25
Identities = 109/414 (26%), Positives = 184/414 (44%), Gaps = 70/414 (16%)
Query: 1584 PRLDRKKRTVNREELLKQAESVMQDLGSS--RAMLEIQYENEVGTGLGPTL-EFYALVSQ 1640
P+ + V+REE+ +++ + + + L +++ E G G E+ L+
Sbjct: 368 PQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCH 427
Query: 1641 ELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFL 1700
E+ GL+ Q T I LQ + + P H++ F F+
Sbjct: 428 EMLNPYYGLF-------------QYSTDNIYMLQ----INPDSSINPDHLSY----FHFV 466
Query: 1701 GKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKK 1760
G++M A+ ++ +PFYK +L + L+ DL +DP + +S+ +
Sbjct: 467 GRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLS--DLESVDPELHKSLVWI-------- 516
Query: 1761 RLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIHNLEE 1820
LE D + + + VE L ELK G+++PVT N +E
Sbjct: 517 -LENDITPVLD-----------HTFCVEHNAFGRILQH----ELKPNGRNVPVTEENKKE 560
Query: 1821 YLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCG-SKAD--TWDAK 1877
Y+RL + W G+ QF + + GF + P L+ F +EL+ ++ G K D W +
Sbjct: 561 YVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSN 620
Query: 1878 TLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL----- 1932
T ++ C DS V++ ++ + +FD E++ LQFVTGS R+P+ GF++L
Sbjct: 621 TRLKHC------VADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTG 674
Query: 1933 --NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 1984
P L + +T+N LP TC N + +P Y S E + EKLL A E
Sbjct: 675 AAGPRLFTIHLIDANTDN----LPKAHTCFNRIDIPPYESYEKLYEKLLTAVEE 724
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 524 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 575
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 576 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 622
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 623 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 662
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 663 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 771
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 772 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 827
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 828 PPYETFEDLREKLLMAVENAQ 848
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 625 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 676
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 677 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 723
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 724 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 763
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 764 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 817
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 818 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 872
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 873 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 928
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 929 PPYETFEDLREKLLMAVENAQ 949
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 504 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 555
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 556 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 602
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 603 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 642
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 643 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 696
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 697 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 751
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 752 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 807
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 808 PPYETFEDLREKLLMAVENAQ 828
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 504 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 555
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 556 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 602
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 603 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 642
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 643 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 696
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 697 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 751
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 752 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 807
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 808 PPYETFEDLREKLLMAVENAQ 828
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 617 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 668
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 669 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 715
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 716 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 755
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 756 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 809
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 810 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 864
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 865 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 920
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 921 PPYETFEDLREKLLMAVENAQ 941
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 637 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 688
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 689 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 735
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 736 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 775
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 776 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 829
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 830 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 884
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 885 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 940
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 941 PPYETFEDLREKLLMAVENAQ 961
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 645 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 696
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 697 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 743
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 744 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 783
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 784 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 837
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 838 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 892
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 893 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 948
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 949 PPYETFEDLREKLLMAVENAQ 969
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 524 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 575
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 576 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 622
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 623 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 662
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 663 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 771
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 772 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 827
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 828 PPYETFEDLREKLLMAVENAQ 848
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 114 bits (284), Expect = 1e-24
Identities = 104/381 (27%), Positives = 172/381 (45%), Gaps = 63/381 (16%)
Query: 1613 RAMLEIQYENEVGTGLGPTL-EFYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQ 1671
+A L I++E+E G G E++ L+S+E+ GL+ + T I
Sbjct: 524 KARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYS--------ATDNYTLQIN 575
Query: 1672 NLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1731
GL H++ F F+G++ A+ +L+D PFYK ML ++
Sbjct: 576 PNSGL--------CNEDHLSY----FTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ- 622
Query: 1732 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1791
+T +D+ +D S+ K LE D T+ L + ++ E+ G
Sbjct: 623 -ITLNDMESVDSEYYNSL---------KWILENDP--TELDLMFCIDE--------ENFG 662
Query: 1792 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPL 1851
+ ++LK G +I VT N EY+ LVI W V +Q ++F +GF + P+
Sbjct: 663 QTY------QVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPI 716
Query: 1852 SHLQYFYPEELDQLLCG---SKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDN 1908
++ F EL+ L+CG + W ++ + +GY + +++ ++ + D
Sbjct: 717 DLIKIFDENELELLMCGLGDVDVNDWRQHSIYK-----NGYCPNHPVIQWFWKAVLLMDA 771
Query: 1909 EQQRLFLQFVTGSPRLPVGGFRSL---NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKL 1965
E++ LQFVTG+ R+P+ GF L N P + + S E LP TC N L L
Sbjct: 772 EKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK----LPRAHTCFNRLDL 827
Query: 1966 PDYSSIEIMREKLLIAAREGQ 1986
P Y + E +REKLL+A Q
Sbjct: 828 PPYETFEDLREKLLMAVENAQ 848
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 112 bits (279), Expect = 5e-24
Identities = 111/416 (26%), Positives = 187/416 (44%), Gaps = 67/416 (16%)
Query: 1585 RLDRKKRTVNREELLKQAESVMQD-----LGSSRA-----MLEIQYENEVGTGLGPTL-E 1633
+L ++ N+ E+ + +V++D +G RA L I+++ E G G E
Sbjct: 532 KLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVARE 591
Query: 1634 FYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKV 1693
++ L+S+E+ GL+ + T I GL H++
Sbjct: 592 WFFLISKEMFNPYYGLFEYS--------ATDNYTLQINPNSGL--------CNEDHLSY- 634
Query: 1694 KMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLE 1753
F+F+G++ A+ +L+D PFYK ML + +T HD+ +D S+ +
Sbjct: 635 ---FKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHK--PITLHDMESVDSEYYNSLRWI- 688
Query: 1754 DIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPV 1813
LE D T+ L++ ++ E+L ELK GG +I V
Sbjct: 689 --------LEND--PTELDLRFIID---------EEL-----FGQTHQHELKNGGSEIVV 724
Query: 1814 TIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADT 1873
T N +EY+ LVI W + +Q +F++GF + P ++ F EL+ L+CG
Sbjct: 725 TNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG--LGD 782
Query: 1874 WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL- 1932
D E + +GY+ + + +++ ++ + D+E++ LQFVTG+ R+P+ GF L
Sbjct: 783 VDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELY 842
Query: 1933 --NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQ 1986
N P + T E P+ LP TC N L LP Y S E + +KL +A Q
Sbjct: 843 GSNGPQSF---TVEQWGTPEK-LPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 894
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 112 bits (279), Expect = 5e-24
Identities = 111/416 (26%), Positives = 187/416 (44%), Gaps = 67/416 (16%)
Query: 1585 RLDRKKRTVNREELLKQAESVMQD-----LGSSRA-----MLEIQYENEVGTGLGPTL-E 1633
+L ++ N+ E+ + +V++D +G RA L I+++ E G G E
Sbjct: 879 KLKKQNDIPNKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVARE 938
Query: 1634 FYALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKV 1693
++ L+S+E+ GL+ + T I GL H++
Sbjct: 939 WFFLISKEMFNPYYGLFEYS--------ATDNYTLQINPNSGL--------CNEDHLSY- 981
Query: 1694 KMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLE 1753
F+F+G++ A+ +L+D PFYK ML + +T HD+ +D S+ +
Sbjct: 982 ---FKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLHK--PITLHDMESVDSEYYNSLRWI- 1035
Query: 1754 DIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPV 1813
LE D T+ L++ ++ E+L ELK GG +I V
Sbjct: 1036 --------LEND--PTELDLRFIID---------EEL-----FGQTHQHELKNGGSEIVV 1071
Query: 1814 TIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADT 1873
T N +EY+ LVI W + +Q +F++GF + P ++ F EL+ L+CG
Sbjct: 1072 TNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG--LGD 1129
Query: 1874 WDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL- 1932
D E + +GY+ + + +++ ++ + D+E++ LQFVTG+ R+P+ GF L
Sbjct: 1130 VDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELY 1189
Query: 1933 --NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAAREGQ 1986
N P + T E P+ LP TC N L LP Y S E + +KL +A Q
Sbjct: 1190 GSNGPQSF---TVEQWGTPEK-LPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQ 1241
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 104 bits (260), Expect = 8e-22
Identities = 85/297 (28%), Positives = 135/297 (45%), Gaps = 44/297 (14%)
Query: 1696 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET------------SLTSHDLFDIDP 1743
+FR +G LM A+ + +D+ YK +L ++T DL I P
Sbjct: 501 EFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMP 560
Query: 1744 VVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIE 1803
+A L +++ + +E+D T + Q E+ G+ +
Sbjct: 561 ELAHG---LSELLSHEGNVEEDFYSTFQVFQ-------------EEFGI------IKSYN 598
Query: 1804 LKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELD 1863
LK GG I VT N +EY++L + LN+ + +QF +F GF SV + L PEE++
Sbjct: 599 LKPGGDKISVTNQNRKEYVQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVE 658
Query: 1864 QLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPR 1923
L+CGS D L + D GY +K+ ++++ F + Q+ L F TGS R
Sbjct: 659 ILVCGS--PDLDMHALQRSTQYD-GYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDR 715
Query: 1924 LPVGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLI 1980
+PVGG LN ++ E + LP TC N L LP Y S + +++KL+I
Sbjct: 716 VPVGGMADLNFKIS-------KNETSTNCLPVAHTCFNQLCLPPYKSKKDLKQKLII 765
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 103 bits (258), Expect = 1e-21
Identities = 118/412 (28%), Positives = 177/412 (42%), Gaps = 80/412 (19%)
Query: 1590 KRTVNREELLKQAESVMQDLGSSRAMLE-----IQYENEVGTGL-GPTLEFYALVSQELQ 1643
K + R+ LL+ A + Q +G SR L+ + + E G GP+ EF+ LVS+EL
Sbjct: 1217 KLIIRRDHLLEDAFN--QIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELF 1274
Query: 1644 RADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKL 1703
GL+ + S T +Q + A + FRF G++
Sbjct: 1275 NPYYGLF----------EYSANDTYTVQI-----------SPMSAFVDNHHEWFRFSGRI 1313
Query: 1704 MAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLE 1763
+ A++ L+D PFYK +LR L+ + D + +H
Sbjct: 1314 LGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEE-------FH------------ 1354
Query: 1764 QDKSQTKESLQYALETLTMNGCSVED-LGLDFTLPG--FPNI---ELKKGGKDIPVTIHN 1817
+SLQ+ M + D L L FT+ F I ELK GG +IPVT N
Sbjct: 1355 -------QSLQW------MKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKN 1401
Query: 1818 LEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCG-SKADTWDA 1876
+EY+ ++ W + GV +Q +S GF V + F EL+ ++ G ++ D D
Sbjct: 1402 KKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDW 1461
Query: 1877 KTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSL---- 1932
+ E GY + +++ + + F+NEQ+ LQFVTG+ +P GF SL
Sbjct: 1462 RNNTEY---RGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSN 1518
Query: 1933 NPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 1984
P V K + T LP TC N L LP Y S ++ EKLL A E
Sbjct: 1519 GPRRFCVEKWGKITA-----LPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1565
Score = 40.4 bits (93), Expect = 0.017
Identities = 59/250 (23%), Positives = 97/250 (38%), Gaps = 21/250 (8%)
Query: 130 TSKAHTRKSGATGGSRSQKRKRTESSCVKSGSGSESTGAEERSAKPTKLASKSATSAK-A 188
TS A T S A+GGSR R +E+ + GS +E + P + S S S +
Sbjct: 577 TSGADTGTSDASGGSR---RAVSETESLDQGSEPSQVSSETEPSDPARTESVSEASTRPE 633
Query: 189 GCSTI--TDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQNKARRSRSASSPSPRRSS 246
G S + DSS S ++ S+V + S++ AR + + A + P S
Sbjct: 634 GESDLECADSSCNESVTTQLSSVDTRCSSL-ESARFPETPAFSSQEEEDGACAAEPTSSG 692
Query: 247 REKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETSKPGPSGLQAKLASLRKST 306
+ GS + A P V +P + PG+ + G + +
Sbjct: 693 PAE------GSQESVCTAGSLPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGA 746
Query: 307 KKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAAEARRQEKMADPESNQEAV 366
+ESPP E + + G+C + + G G ++A + + S ++ V
Sbjct: 747 AAAAESPPQE-----EGSAGEAQGTCEGATAQEE--GATGGSQANGHQPLRSLPSVRQDV 799
Query: 367 NSSAARTDEA 376
S R DEA
Sbjct: 800 -SRYQRVDEA 808
Score = 32.0 bits (71), Expect = 6.2
Identities = 47/241 (19%), Positives = 83/241 (34%), Gaps = 10/241 (4%)
Query: 169 EERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPPGARVKQGKDQ 228
EE P S SA+ S D ++ + + +S A + V + QG +
Sbjct: 548 EEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGSRRAVSETESLDQGSEP 607
Query: 229 NKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTKLSLPGSSKSETS 288
++ S P+ S E G S + + V+ + + SS
Sbjct: 608 SQVSSETEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRCSSLESAR 667
Query: 289 KPGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRRGSGLGKRGAA 348
P ++ + + S PAE S T + SG + A
Sbjct: 668 FPETPAFSSQEEEDGACAAEPTSSGPAE-----GSQESVCTAGSLPVVQVPSGEDEGPGA 722
Query: 349 EARR---QEKMADPESNQEAVNSSAARTDEAPQ--GAAGAVGMTTSGESESDDSEMGRLQ 403
E+ QE++ + + ++ +AA + PQ G+AG T G + ++ G Q
Sbjct: 723 ESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGTCEGATAQEEGATGGSQ 782
Query: 404 A 404
A
Sbjct: 783 A 783
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 103 bits (256), Expect = 2e-21
Identities = 79/285 (27%), Positives = 129/285 (45%), Gaps = 32/285 (11%)
Query: 1697 FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIV 1756
F +G + AI + +VDL L YK +L+++ SL DL ++ P V RS+ L D
Sbjct: 787 FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLD--DLKELMPDVGRSMQQLLDY- 843
Query: 1757 RQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIH 1816
+D + L + + V++L L+ G D V
Sbjct: 844 ------PEDDIEETFCLNFTITVENFGATEVKELVLN--------------GADTAVNKQ 883
Query: 1817 NLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDA 1876
N +E++ + + N+ V+ FD+F GF V L F P EL ++ G+ +D
Sbjct: 884 NRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGN--TNYDW 941
Query: 1877 KTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPL 1936
K L + Y + +K +E+ E+++ FL F+TGS R+P+ G +SL
Sbjct: 942 KELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL---- 997
Query: 1937 TIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIA 1981
+ +ST +++LP TC N L LP Y+ E +R KL+ A
Sbjct: 998 ---KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQA 1039
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 103 bits (256), Expect = 2e-21
Identities = 79/285 (27%), Positives = 129/285 (45%), Gaps = 32/285 (11%)
Query: 1697 FRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIV 1756
F +G + AI + +VDL L YK +L+++ SL DL ++ P V RS+ L D
Sbjct: 795 FHLIGVICGLAIYNCTIVDLHFPLALYKKLLKKKPSLD--DLKELMPDVGRSMQQLLDY- 851
Query: 1757 RQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGKDIPVTIH 1816
+D + L + + V++L L+ G D V
Sbjct: 852 ------PEDDIEETFCLNFTITVENFGATEVKELVLN--------------GADTAVNKQ 891
Query: 1817 NLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYFYPEELDQLLCGSKADTWDA 1876
N +E++ + + N+ V+ FD+F GF V L F P EL ++ G+ +D
Sbjct: 892 NRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGN--TNYDW 949
Query: 1877 KTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPL 1936
K L + Y + +K +E+ E+++ FL F+TGS R+P+ G +SL
Sbjct: 950 KELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIPILGMKSL---- 1005
Query: 1937 TIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMREKLLIA 1981
+ +ST +++LP TC N L LP Y+ E +R KL+ A
Sbjct: 1006 ---KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQA 1047
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,368,508
Number of Sequences: 37866
Number of extensions: 3573975
Number of successful extensions: 24433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 194
Number of HSP's successfully gapped in prelim test: 841
Number of HSP's that attempted gapping in prelim test: 17792
Number of HSP's gapped (non-prelim): 4984
length of query: 1992
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1875
effective length of database: 13,817,196
effective search space: 25907242500
effective search space used: 25907242500
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.