Search of human proteins with 10835256

Search of human proteins with 10835256

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10835256 PYD and CARD domain containing isoform a [Homo
sapiens]
         (195 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10835256 PYD and CARD domain containing isoform a [Homo sapiens]   385   e-108
gi|22035620 PYD and CARD domain containing isoform b [Homo sapiens]   337   5e-93
gi|23097246 pyrin domain containing 1 [Homo sapiens]                  107   6e-24
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo...   100   1e-21
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom...   100   1e-21
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom...   100   1e-21
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom...   100   1e-21
gi|4557743 Mediterranean fever protein [Homo sapiens]                  52   4e-07
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]       50   9e-07
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]      46   2e-05
gi|7662404 caspase recruitment domain family, member 8 [Homo sap...    41   7e-04
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso...    40   0.001
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof...    40   0.001
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof...    40   0.001
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho...    35   0.031
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...    35   0.031
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho...    35   0.031
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom...    35   0.031
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...    35   0.031
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...    33   0.20 
gi|5174617 nucleotide-binding oligomerization domain containing ...    32   0.26 
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom...    32   0.34 
gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens]        32   0.45 
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ...    31   0.76 
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]      30   1.7  
gi|56549645 nucleoporin 98kD isoform 4 [Homo sapiens]                  29   2.2  
gi|56549643 nucleoporin 98kD isoform 3 [Homo sapiens]                  29   2.2  
gi|21264365 nucleoporin 98kD isoform 1 [Homo sapiens]                  29   2.2  
gi|21264369 nucleoporin 98kD isoform 2 [Homo sapiens]                  29   2.2  
gi|4507973 zinc finger protein of the cerebellum 3 [Homo sapiens]      29   2.9  

>gi|10835256 PYD and CARD domain containing isoform a [Homo sapiens]
          Length = 195

 Score =  385 bits (990), Expect = e-108
 Identities = 195/195 (100%), Positives = 195/195 (100%)

Query: 1   MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60
           MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
Sbjct: 1   MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60

Query: 61  LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA 120
           LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA
Sbjct: 61  LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA 120

Query: 121 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA 180
           ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
Sbjct: 121 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA 180

Query: 181 LRESQSYLVEDLERS 195
           LRESQSYLVEDLERS
Sbjct: 181 LRESQSYLVEDLERS 195


>gi|22035620 PYD and CARD domain containing isoform b [Homo sapiens]
          Length = 176

 Score =  337 bits (863), Expect = 5e-93
 Identities = 176/195 (90%), Positives = 176/195 (90%), Gaps = 19/195 (9%)

Query: 1   MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60
           MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY
Sbjct: 1   MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60

Query: 61  LETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQHRA 120
           LETYGAELTANVLRDMGLQEMAGQLQAATHQ                   GLHFIDQHRA
Sbjct: 61  LETYGAELTANVLRDMGLQEMAGQLQAATHQ-------------------GLHFIDQHRA 101

Query: 121 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA 180
           ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA
Sbjct: 102 ALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNPSKMRKLFSFTPAWNWTCKDLLLQA 161

Query: 181 LRESQSYLVEDLERS 195
           LRESQSYLVEDLERS
Sbjct: 162 LRESQSYLVEDLERS 176


>gi|23097246 pyrin domain containing 1 [Homo sapiens]
          Length = 89

 Score =  107 bits (267), Expect = 6e-24
 Identities = 57/88 (64%), Positives = 66/88 (75%)

Query: 1  MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60
          MG  R+AIL  LENLT EELKKFK+KL +VPLREG+ RIPRGAL  +D +DLTDKLV+ Y
Sbjct: 1  MGTKREAILKVLENLTPEELKKFKMKLGTVPLREGFERIPRGALGQLDIVDLTDKLVASY 60

Query: 61 LETYGAELTANVLRDMGLQEMAGQLQAA 88
           E Y AEL   VLRDM + E A +LQ A
Sbjct: 61 YEDYAAELVVAVLRDMRMLEEAARLQRA 88


>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
            sapiens]
          Length = 1429

 Score = 99.8 bits (247), Expect = 1e-21
 Identities = 51/96 (53%), Positives = 68/96 (70%)

Query: 97   PAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNP 156
            PA I  P    A   LHF+DQ+R  LIARVT+VE +LD L+G+VL+ EQY+ V AE T P
Sbjct: 1320 PARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRP 1379

Query: 157  SKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDL 192
            S+MRKLFS + +W+  CKD L QAL+E+  +L+ +L
Sbjct: 1380 SQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL 1415



 Score = 32.0 bits (71), Expect = 0.34
 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 6/95 (6%)

Query: 12  LENLTAEELKKFKLKLLS-VPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTA 70
           LE L  EELK+F+L L +    R   G  P         +++   LV+ Y E    +L  
Sbjct: 13  LEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRAWDLAL 71

Query: 71  NVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ 105
           +    MGL+ +  Q Q    +G+G +P+   +P +
Sbjct: 72  HTWEQMGLRSLCAQAQ----EGAGHSPSFPYSPSE 102


>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
            sapiens]
          Length = 1399

 Score = 99.8 bits (247), Expect = 1e-21
 Identities = 51/96 (53%), Positives = 68/96 (70%)

Query: 97   PAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNP 156
            PA I  P    A   LHF+DQ+R  LIARVT+VE +LD L+G+VL+ EQY+ V AE T P
Sbjct: 1290 PARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRP 1349

Query: 157  SKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDL 192
            S+MRKLFS + +W+  CKD L QAL+E+  +L+ +L
Sbjct: 1350 SQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL 1385



 Score = 32.0 bits (71), Expect = 0.34
 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 6/95 (6%)

Query: 12  LENLTAEELKKFKLKLLS-VPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTA 70
           LE L  EELK+F+L L +    R   G  P         +++   LV+ Y E    +L  
Sbjct: 13  LEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRAWDLAL 71

Query: 71  NVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ 105
           +    MGL+ +  Q Q    +G+G +P+   +P +
Sbjct: 72  HTWEQMGLRSLCAQAQ----EGAGHSPSFPYSPSE 102


>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
            sapiens]
          Length = 1443

 Score = 99.8 bits (247), Expect = 1e-21
 Identities = 51/96 (53%), Positives = 68/96 (70%)

Query: 97   PAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNP 156
            PA I  P    A   LHF+DQ+R  LIARVT+VE +LD L+G+VL+ EQY+ V AE T P
Sbjct: 1334 PARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRP 1393

Query: 157  SKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDL 192
            S+MRKLFS + +W+  CKD L QAL+E+  +L+ +L
Sbjct: 1394 SQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL 1429



 Score = 32.0 bits (71), Expect = 0.34
 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 6/95 (6%)

Query: 12  LENLTAEELKKFKLKLLS-VPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTA 70
           LE L  EELK+F+L L +    R   G  P         +++   LV+ Y E    +L  
Sbjct: 13  LEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRAWDLAL 71

Query: 71  NVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ 105
           +    MGL+ +  Q Q    +G+G +P+   +P +
Sbjct: 72  HTWEQMGLRSLCAQAQ----EGAGHSPSFPYSPSE 102


>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
            sapiens]
          Length = 1473

 Score = 99.8 bits (247), Expect = 1e-21
 Identities = 51/96 (53%), Positives = 68/96 (70%)

Query: 97   PAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRAEPTNP 156
            PA I  P    A   LHF+DQ+R  LIARVT+VE +LD L+G+VL+ EQY+ V AE T P
Sbjct: 1364 PARIAVPSPLDAPQLLHFVDQYREQLIARVTSVEVVLDKLHGQVLSQEQYERVLAENTRP 1423

Query: 157  SKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDL 192
            S+MRKLFS + +W+  CKD L QAL+E+  +L+ +L
Sbjct: 1424 SQMRKLFSLSQSWDRKCKDGLYQALKETHPHLIMEL 1459



 Score = 32.0 bits (71), Expect = 0.34
 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 6/95 (6%)

Query: 12  LENLTAEELKKFKLKLLS-VPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTA 70
           LE L  EELK+F+L L +    R   G  P         +++   LV+ Y E    +L  
Sbjct: 13  LEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRAWDLAL 71

Query: 71  NVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ 105
           +    MGL+ +  Q Q    +G+G +P+   +P +
Sbjct: 72  HTWEQMGLRSLCAQAQ----EGAGHSPSFPYSPSE 102


>gi|4557743 Mediterranean fever protein [Homo sapiens]
          Length = 781

 Score = 51.6 bits (122), Expect = 4e-07
 Identities = 28/86 (32%), Positives = 46/86 (53%)

Query: 6  DAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYG 65
          D +L  LE L   + +KFK KL +  +++ + RIPR  +     + +   LV++Y E Y 
Sbjct: 7  DHLLSTLEELVPYDFEKFKFKLQNTSVQKEHSRIPRSQIQRARPVKMATLLVTYYGEEYA 66

Query: 66 AELTANVLRDMGLQEMAGQLQAATHQ 91
           +LT  VLR +  + +A +L  A  Q
Sbjct: 67 VQLTLQVLRAINQRLLAEELHRAAIQ 92


>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
          Length = 892

 Score = 50.4 bits (119), Expect = 9e-07
 Identities = 38/116 (32%), Positives = 56/116 (48%), Gaps = 4/116 (3%)

Query: 4   ARDAILDALENLTAEELKKFKLKLLSVPLREGYGR-IPRGALLSMDALDLTDKLVSFYLE 62
           AR+ +L ALE L+ E+LK+F+ KL  V      GR IP G L   DA+DL ++L  FY  
Sbjct: 18  ARELLLAALEELSQEQLKRFRHKLRDVGPD---GRSIPWGRLERADAVDLAEQLAQFYGP 74

Query: 63  TYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQSAAKPGLHFIDQH 118
               E+    L+    +++A QLQ    Q  G     + +  +   K   H +  H
Sbjct: 75  EPALEVARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLH 130


>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
          Length = 655

 Score = 46.2 bits (108), Expect = 2e-05
 Identities = 28/83 (33%), Positives = 43/83 (51%)

Query: 3  RARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLE 62
          + R+A+L AL +L   + KK K  L  + L EG   + RG L  +  +DL + L+S Y E
Sbjct: 8  KPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGE 67

Query: 63 TYGAELTANVLRDMGLQEMAGQL 85
              ++    L+ M L E+  QL
Sbjct: 68 KEAVKVVLKGLKVMNLLELVDQL 90


>gi|7662404 caspase recruitment domain family, member 8 [Homo
           sapiens]
          Length = 431

 Score = 40.8 bits (94), Expect = 7e-04
 Identities = 30/101 (29%), Positives = 48/101 (47%), Gaps = 3/101 (2%)

Query: 97  PAGIQAPPQSAAKP--GLHFIDQHRAALIARVTNVEWLLDALY-GKVLTDEQYQAVRAEP 153
           P  +Q    SA  P  G  F+ ++   L AR+ +++ +LD L   +VLT+ + + V  E 
Sbjct: 328 PVDLQLVAASAPPPFSGAAFVKENHRQLQARMGDLKGVLDDLQDNEVLTENEKELVEQEK 387

Query: 154 TNPSKMRKLFSFTPAWNWTCKDLLLQALRESQSYLVEDLER 194
           T  SK   L S          D+L +++ E   YLV  L +
Sbjct: 388 TRQSKNEALLSMVEKKGDLALDVLFRSISERDPYLVSYLRQ 428


>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
          isoform 3 [Homo sapiens]
          Length = 1037

 Score = 40.0 bits (92), Expect = 0.001
 Identities = 24/76 (31%), Positives = 36/76 (47%)

Query: 12 LENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTAN 71
          LE L  +ELK FK  L + PL +   + P   +   D   L + LV+   E +    T N
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73

Query: 72 VLRDMGLQEMAGQLQA 87
          +L +M L E+    +A
Sbjct: 74 ILEEMNLTELCKMAKA 89


>gi|75709196 NACHT, leucine rich repeat and PYD containing 7
          isoform 2 [Homo sapiens]
          Length = 980

 Score = 40.0 bits (92), Expect = 0.001
 Identities = 24/76 (31%), Positives = 36/76 (47%)

Query: 12 LENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTAN 71
          LE L  +ELK FK  L + PL +   + P   +   D   L + LV+   E +    T N
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73

Query: 72 VLRDMGLQEMAGQLQA 87
          +L +M L E+    +A
Sbjct: 74 ILEEMNLTELCKMAKA 89


>gi|46049100 NACHT, leucine rich repeat and PYD containing 7
          isoform 1 [Homo sapiens]
          Length = 1009

 Score = 40.0 bits (92), Expect = 0.001
 Identities = 24/76 (31%), Positives = 36/76 (47%)

Query: 12 LENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTAN 71
          LE L  +ELK FK  L + PL +   + P   +   D   L + LV+   E +    T N
Sbjct: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73

Query: 72 VLRDMGLQEMAGQLQA 87
          +L +M L E+    +A
Sbjct: 74 ILEEMNLTELCKMAKA 89


>gi|119395764 NLR family, pyrin domain containing 3 isoform a
          [Homo sapiens]
          Length = 1036

 Score = 35.4 bits (80), Expect = 0.031
 Identities = 20/59 (33%), Positives = 30/59 (50%)

Query: 1  MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSF 59
          M   R  +   LE+L   +LKKFK+ L   P ++G   +PRG     D +DL   ++ F
Sbjct: 3  MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61


>gi|188536116 NLR family, pyrin domain containing 3 isoform c
          [Homo sapiens]
          Length = 979

 Score = 35.4 bits (80), Expect = 0.031
 Identities = 20/59 (33%), Positives = 30/59 (50%)

Query: 1  MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSF 59
          M   R  +   LE+L   +LKKFK+ L   P ++G   +PRG     D +DL   ++ F
Sbjct: 3  MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61


>gi|188536002 NLR family, pyrin domain containing 3 isoform d
          [Homo sapiens]
          Length = 979

 Score = 35.4 bits (80), Expect = 0.031
 Identities = 20/59 (33%), Positives = 30/59 (50%)

Query: 1  MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSF 59
          M   R  +   LE+L   +LKKFK+ L   P ++G   +PRG     D +DL   ++ F
Sbjct: 3  MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61


>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
          sapiens]
          Length = 1036

 Score = 35.4 bits (80), Expect = 0.031
 Identities = 20/59 (33%), Positives = 30/59 (50%)

Query: 1  MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSF 59
          M   R  +   LE+L   +LKKFK+ L   P ++G   +PRG     D +DL   ++ F
Sbjct: 3  MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
          sapiens]
          Length = 922

 Score = 35.4 bits (80), Expect = 0.031
 Identities = 20/59 (33%), Positives = 30/59 (50%)

Query: 1  MGRARDAILDALENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSF 59
          M   R  +   LE+L   +LKKFK+ L   P ++G   +PRG     D +DL   ++ F
Sbjct: 3  MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDF 61


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2
          [Homo sapiens]
          Length = 1061

 Score = 32.7 bits (73), Expect = 0.20
 Identities = 19/49 (38%), Positives = 27/49 (55%), Gaps = 1/49 (2%)

Query: 12 LENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFY 60
          LE L A ELKKFKL  L      G G+IP G++     L++   L++ +
Sbjct: 17 LEELEAVELKKFKL-YLGTATELGEGKIPWGSMEKAGPLEMAQLLITHF 64


>gi|5174617 nucleotide-binding oligomerization domain containing 1
           [Homo sapiens]
          Length = 953

 Score = 32.3 bits (72), Expect = 0.26
 Identities = 19/79 (24%), Positives = 35/79 (44%), Gaps = 1/79 (1%)

Query: 106 SAAKPGLHFIDQHRAALIARVTNVEWLLDALY-GKVLTDEQYQAVRAEPTNPSKMRKLFS 164
           S + P +  +  +R  L+  + N + L+D L      + E  + V A PT P K+RK+  
Sbjct: 14  SESHPHIQLLKSNRELLVTHIRNTQCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKILD 73

Query: 165 FTPAWNWTCKDLLLQALRE 183
              +      +  L  L++
Sbjct: 74  LVQSKGEEVSEFFLYLLQQ 92


>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
           sapiens]
          Length = 1375

 Score = 32.0 bits (71), Expect = 0.34
 Identities = 27/95 (28%), Positives = 44/95 (46%), Gaps = 6/95 (6%)

Query: 12  LENLTAEELKKFKLKLLS-VPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTA 70
           LE L  EELK+F+L L +    R   G  P         +++   LV+ Y E    +L  
Sbjct: 13  LEFLKKEELKEFQLLLANKAHSRSSSGETP-AQPEKTSGMEVASYLVAQYGEQRAWDLAL 71

Query: 71  NVLRDMGLQEMAGQLQAATHQGSGAAPAGIQAPPQ 105
           +    MGL+ +  Q Q    +G+G +P+   +P +
Sbjct: 72  HTWEQMGLRSLCAQAQ----EGAGHSPSFPYSPSE 102


>gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens]
          Length = 559

 Score = 31.6 bits (70), Expect = 0.45
 Identities = 17/65 (26%), Positives = 31/65 (47%)

Query: 42  GALLSMDALDLTDKLVSFYLETYGAELTANVLRDMGLQEMAGQLQAATHQGSGAAPAGIQ 101
           GA L++ + D     V+F  +  G  L    + +M   + A + ++ TH+GS   P  ++
Sbjct: 358 GAFLAISSTDGYCSFVTFEKDELGIPLKEKPVLNMRTPDTAKKTKSQTHRGSSPGPRPVE 417

Query: 102 APPQS 106
             P S
Sbjct: 418 GTPAS 422


>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
           sapiens]
          Length = 540

 Score = 30.8 bits (68), Expect = 0.76
 Identities = 21/82 (25%), Positives = 43/82 (52%), Gaps = 5/82 (6%)

Query: 109 KPGL--HFIDQHRAALIARVTN--VEWLLDALYGK-VLTDEQYQAVRAEPTNPSKMRKLF 163
           +PG+   +I   R  ++ ++T   +   LDAL  + ++  E Y+ V  +PT  SK+R+L 
Sbjct: 432 QPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLL 491

Query: 164 SFTPAWNWTCKDLLLQALRESQ 185
             T         +++Q L++++
Sbjct: 492 DTTDIQGEEFAKVIVQKLKDNK 513


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score = 29.6 bits (65), Expect = 1.7
 Identities = 18/70 (25%), Positives = 32/70 (45%)

Query: 12 LENLTAEELKKFKLKLLSVPLREGYGRIPRGALLSMDALDLTDKLVSFYLETYGAELTAN 71
          LE L  EE +KFK  L  + L+    +IP   +      +L + L+  Y E     +T  
Sbjct: 15 LEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITLR 74

Query: 72 VLRDMGLQEM 81
          + + M  +++
Sbjct: 75 IFQKMDRKDL 84


>gi|56549645 nucleoporin 98kD isoform 4 [Homo sapiens]
          Length = 1726

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 26/107 (24%), Positives = 48/107 (44%), Gaps = 11/107 (10%)

Query: 92  GSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRA 151
           G+  AP  +  P  SAA+  +  + QH    I  +T   +    L+   ++D + +  R 
Sbjct: 463 GAPQAPVALTDPNASAAQQAV--LQQH----INSLTYSPFGDSPLFRNPMSDPKKKEERL 516

Query: 152 EPTNPSKMRKL-----FSFTPAWNWTCKDLLLQALRESQSYLVEDLE 193
           +PTNP+  + L     +  TP      +   LQ    ++S+L + L+
Sbjct: 517 KPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLD 563


>gi|56549643 nucleoporin 98kD isoform 3 [Homo sapiens]
          Length = 937

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 26/107 (24%), Positives = 48/107 (44%), Gaps = 11/107 (10%)

Query: 92  GSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRA 151
           G+  AP  +  P  SAA+  +  + QH    I  +T   +    L+   ++D + +  R 
Sbjct: 480 GAPQAPVALTDPNASAAQQAV--LQQH----INSLTYSPFGDSPLFRNPMSDPKKKEERL 533

Query: 152 EPTNPSKMRKL-----FSFTPAWNWTCKDLLLQALRESQSYLVEDLE 193
           +PTNP+  + L     +  TP      +   LQ    ++S+L + L+
Sbjct: 534 KPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLD 580


>gi|21264365 nucleoporin 98kD isoform 1 [Homo sapiens]
          Length = 1800

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 26/107 (24%), Positives = 48/107 (44%), Gaps = 11/107 (10%)

Query: 92  GSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRA 151
           G+  AP  +  P  SAA+  +  + QH    I  +T   +    L+   ++D + +  R 
Sbjct: 463 GAPQAPVALTDPNASAAQQAV--LQQH----INSLTYSPFGDSPLFRNPMSDPKKKEERL 516

Query: 152 EPTNPSKMRKL-----FSFTPAWNWTCKDLLLQALRESQSYLVEDLE 193
           +PTNP+  + L     +  TP      +   LQ    ++S+L + L+
Sbjct: 517 KPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLD 563


>gi|21264369 nucleoporin 98kD isoform 2 [Homo sapiens]
          Length = 920

 Score = 29.3 bits (64), Expect = 2.2
 Identities = 26/107 (24%), Positives = 48/107 (44%), Gaps = 11/107 (10%)

Query: 92  GSGAAPAGIQAPPQSAAKPGLHFIDQHRAALIARVTNVEWLLDALYGKVLTDEQYQAVRA 151
           G+  AP  +  P  SAA+  +  + QH    I  +T   +    L+   ++D + +  R 
Sbjct: 463 GAPQAPVALTDPNASAAQQAV--LQQH----INSLTYSPFGDSPLFRNPMSDPKKKEERL 516

Query: 152 EPTNPSKMRKL-----FSFTPAWNWTCKDLLLQALRESQSYLVEDLE 193
           +PTNP+  + L     +  TP      +   LQ    ++S+L + L+
Sbjct: 517 KPTNPAAQKALTTPTHYKLTPRPATRVRPKALQTTGTAKSHLFDGLD 563


>gi|4507973 zinc finger protein of the cerebellum 3 [Homo sapiens]
          Length = 467

 Score = 28.9 bits (63), Expect = 2.9
 Identities = 29/90 (32%), Positives = 38/90 (42%), Gaps = 10/90 (11%)

Query: 74  RDMGLQEMA-GQLQAATHQGSGA---APAGIQAPPQSAAKPGLHFIDQHRAALIARVTNV 129
           R  GL E A G  Q     GS +   APAGI  PP     PGLH       +    V N 
Sbjct: 123 RSSGLSEAASGGGQHGLFAGSASSLHAPAGIPEPPSYLLFPGLHEQGAGHPSPTGHVDNN 182

Query: 130 E---WLLDALYGKVLTDEQYQAVRAEPTNP 156
           +    L   L+G+    + Y+ V +  T+P
Sbjct: 183 QVHLGLRGELFGRA---DPYRPVASPRTDP 209


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 6,841,350
Number of Sequences: 37866
Number of extensions: 274051
Number of successful extensions: 1105
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1073
Number of HSP's gapped (non-prelim): 41
length of query: 195
length of database: 18,247,518
effective HSP length: 97
effective length of query: 98
effective length of database: 14,574,516
effective search space: 1428302568
effective search space used: 1428302568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.