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Search of human proteins with 239747543
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239747543 PREDICTED: hypothetical protein XP_002347646 [Homo
sapiens]
(80 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239747543 PREDICTED: hypothetical protein XP_002347646 [Homo ... 164 1e-41
gi|239754420 PREDICTED: hypothetical protein [Homo sapiens] 108 1e-24
gi|239742965 PREDICTED: hypothetical protein XP_002342706 [Homo ... 108 1e-24
gi|169171558 PREDICTED: hypothetical protein [Homo sapiens] 34 0.022
gi|194578898 hypothetical protein LOC100170841 [Homo sapiens] 33 0.064
gi|91208420 bassoon protein [Homo sapiens] 32 0.11
gi|169177385 PREDICTED: hypothetical protein [Homo sapiens] 30 0.42
gi|19923748 dihydrolipoamide S-succinyltransferase (E2 component... 30 0.42
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 30 0.42
gi|110618248 mucin and cadherin-like isoform 1 [Homo sapiens] 30 0.54
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 29 0.71
gi|110832843 TBP-associated factor 4 [Homo sapiens] 29 0.93
gi|239746705 PREDICTED: hypothetical protein XP_002343815 [Homo ... 28 1.2
gi|169177307 PREDICTED: hypothetical protein [Homo sapiens] 28 1.2
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 28 1.2
gi|153285461 fibroblast growth factor 2 [Homo sapiens] 28 1.6
gi|239756085 PREDICTED: hypothetical protein [Homo sapiens] 28 1.6
gi|239750614 PREDICTED: hypothetical protein [Homo sapiens] 28 1.6
gi|239744921 PREDICTED: hypothetical protein XP_002343308 [Homo ... 28 1.6
gi|139394621 chondroitin sulfate proteoglycan 5 (neuroglycan C) ... 28 1.6
gi|22547197 zinc finger protein of the cerebellum 2 [Homo sapiens] 28 1.6
gi|154426272 hypothetical protein LOC54540 [Homo sapiens] 28 1.6
gi|239756307 PREDICTED: similar to ubiquitin-associated protein ... 28 2.1
gi|239755362 PREDICTED: hypothetical protein [Homo sapiens] 28 2.1
gi|239750857 PREDICTED: similar to ubiquitin-associated protein ... 28 2.1
gi|239749695 PREDICTED: hypothetical protein XP_002347121 [Homo ... 28 2.1
gi|239745220 PREDICTED: hypothetical protein [Homo sapiens] 28 2.1
gi|239743961 PREDICTED: hypothetical protein XP_002344246 [Homo ... 28 2.1
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 28 2.1
gi|73476377 LBXCOR1 homolog [Homo sapiens] 28 2.1
>gi|239747543 PREDICTED: hypothetical protein XP_002347646 [Homo
sapiens]
Length = 80
Score = 164 bits (415), Expect = 1e-41
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 1 MGLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGA 60
MGLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGA
Sbjct: 1 MGLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGA 60
Query: 61 KPLTAQSPVVPAGRSEREEF 80
KPLTAQSPVVPAGRSEREEF
Sbjct: 61 KPLTAQSPVVPAGRSEREEF 80
>gi|239754420 PREDICTED: hypothetical protein [Homo sapiens]
Length = 105
Score = 108 bits (269), Expect = 1e-24
Identities = 55/71 (77%), Positives = 58/71 (81%)
Query: 1 MGLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGA 60
MGLGA+EQGA LV EAR AQEPTE EAQAW AAGP+ CPAGRQLRP EKLSTAAAGPGA
Sbjct: 12 MGLGAMEQGAALVREARAAQEPTERGEAQAWRAAGPEPCPAGRQLRPREKLSTAAAGPGA 71
Query: 61 KPLTAQSPVVP 71
PLTA+ P
Sbjct: 72 TPLTARGGGAP 82
>gi|239742965 PREDICTED: hypothetical protein XP_002342706 [Homo
sapiens]
Length = 105
Score = 108 bits (269), Expect = 1e-24
Identities = 55/71 (77%), Positives = 58/71 (81%)
Query: 1 MGLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGA 60
MGLGA+EQGA LV EAR AQEPTE EAQAW AAGP+ CPAGRQLRP EKLSTAAAGPGA
Sbjct: 12 MGLGAMEQGAALVREARAAQEPTERGEAQAWRAAGPEPCPAGRQLRPREKLSTAAAGPGA 71
Query: 61 KPLTAQSPVVP 71
PLTA+ P
Sbjct: 72 TPLTARGGGAP 82
>gi|169171558 PREDICTED: hypothetical protein [Homo sapiens]
Length = 303
Score = 34.3 bits (77), Expect = 0.022
Identities = 14/29 (48%), Positives = 19/29 (65%)
Query: 42 GRQLRPGEKLSTAAAGPGAKPLTAQSPVV 70
G Q RP + S AGP A+PL +Q+P+V
Sbjct: 95 GEQYRPSNEQSQVTAGPPARPLASQAPIV 123
>gi|194578898 hypothetical protein LOC100170841 [Homo sapiens]
Length = 379
Score = 32.7 bits (73), Expect = 0.064
Identities = 22/55 (40%), Positives = 25/55 (45%), Gaps = 4/55 (7%)
Query: 22 PTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAKPLTAQSPVVPAGRSE 76
P G E Q AA P P+ R P LST AGPG TA P +P +E
Sbjct: 160 PAPGLEPQRGPAASPPQEPSSRPPSPPAGLSTEPAGPG----TAPRPFLPGQPAE 210
>gi|91208420 bassoon protein [Homo sapiens]
Length = 3926
Score = 32.0 bits (71), Expect = 0.11
Identities = 20/64 (31%), Positives = 27/64 (42%)
Query: 14 GEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAKPLTAQSPVVPAG 73
G A+ P +G QA A GP RPG A PGA + S ++P G
Sbjct: 3844 GSKGTAKAPQQGRAPQAQPAPGPGPAGVKAGARPGGTPGAPAGQPGADGESVFSKILPGG 3903
Query: 74 RSER 77
+E+
Sbjct: 3904 AAEQ 3907
Score = 25.8 bits (55), Expect = 7.8
Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Query: 34 AGPKLCPA-GRQLRPGEKLSTAAAGPGAKPLTAQSPVVPAGRSERE 78
+GP PA G + PG ++ + GPGA P T + GR+E +
Sbjct: 402 SGPGPGPAPGAKTEPGARMGPGS-GPGALPKTGGTTSPKHGRAEHQ 446
>gi|169177385 PREDICTED: hypothetical protein [Homo sapiens]
Length = 223
Score = 30.0 bits (66), Expect = 0.42
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 7/65 (10%)
Query: 2 GLGAVEQGATLVG-EAREAQEPTEGAEAQAWWA------AGPKLCPAGRQLRPGEKLSTA 54
G+G +G L G +AR +P WA A PKL A PG ++ A
Sbjct: 81 GIGGAGRGQGLAGSQARSTCDPEAAQAMLTTWAPSYRRQATPKLAGAPSLADPGLDVAVA 140
Query: 55 AAGPG 59
AA PG
Sbjct: 141 AAKPG 145
>gi|19923748 dihydrolipoamide S-succinyltransferase (E2 component of
2-oxo-glutarate complex) [Homo sapiens]
Length = 453
Score = 30.0 bits (66), Expect = 0.42
Identities = 22/69 (31%), Positives = 28/69 (40%), Gaps = 11/69 (15%)
Query: 4 GAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAKPL 63
G VE G L + P + A+A AA PK P + AA P A P+
Sbjct: 132 GKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEP-----------TAAAVPPPAAPI 180
Query: 64 TAQSPVVPA 72
Q P VP+
Sbjct: 181 PTQMPPVPS 189
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 30.0 bits (66), Expect = 0.42
Identities = 18/73 (24%), Positives = 29/73 (39%), Gaps = 7/73 (9%)
Query: 2 GLGAVEQGATLVGEAR-------EAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTA 54
GLG EQG L AR ++ T E + W P+ CP + ++ ++
Sbjct: 511 GLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQEASE 570
Query: 55 AAGPGAKPLTAQS 67
P + L+ S
Sbjct: 571 GGDPASPALSLSS 583
>gi|110618248 mucin and cadherin-like isoform 1 [Homo sapiens]
Length = 845
Score = 29.6 bits (65), Expect = 0.54
Identities = 19/70 (27%), Positives = 26/70 (37%), Gaps = 1/70 (1%)
Query: 4 GAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAKPL 63
G + E EP++G + P+G LRP ST PGA+
Sbjct: 469 GTTGPWTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSGTTLRPPTS-STPGGPPGAENS 527
Query: 64 TAQSPVVPAG 73
T+ P P G
Sbjct: 528 TSHQPATPGG 537
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 29.3 bits (64), Expect = 0.71
Identities = 13/31 (41%), Positives = 15/31 (48%)
Query: 32 WAAGPKLCPAGRQLRPGEKLSTAAAGPGAKP 62
W GP PAG QLR + S+ G G P
Sbjct: 43 WCKGPGAGPAGPQLREAARASSGLGGGGRHP 73
>gi|110832843 TBP-associated factor 4 [Homo sapiens]
Length = 1085
Score = 28.9 bits (63), Expect = 0.93
Identities = 21/60 (35%), Positives = 25/60 (41%), Gaps = 7/60 (11%)
Query: 16 AREAQEPTEGAE-------AQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAKPLTAQSP 68
A + + P EG+ A A AAGP+ PAG G A AGPG P P
Sbjct: 123 AAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGP 182
>gi|239746705 PREDICTED: hypothetical protein XP_002343815 [Homo
sapiens]
Length = 411
Score = 28.5 bits (62), Expect = 1.2
Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 2/72 (2%)
Query: 1 MGLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGA 60
+G+G E G +L G A A+ A +LC A Q P + A P A
Sbjct: 127 VGVGDPEAGGSLHGCAGSARAAVGAVSGPDLAARSSRLCRANYQAPP--PTAYHAPPPTA 184
Query: 61 KPLTAQSPVVPA 72
+P +A P P+
Sbjct: 185 QPTSAAHPAAPS 196
>gi|169177307 PREDICTED: hypothetical protein [Homo sapiens]
Length = 223
Score = 28.5 bits (62), Expect = 1.2
Identities = 22/65 (33%), Positives = 28/65 (43%), Gaps = 7/65 (10%)
Query: 2 GLGAVEQGATLVG-EAREAQEPTEGAEAQAWWA------AGPKLCPAGRQLRPGEKLSTA 54
G+G +G L G +AR +P WA A PKL A PG ++ A
Sbjct: 81 GIGGAGRGQGLGGSQARGTCDPEAAQAMLTTWAPSYRRQATPKLAGAPSLADPGMDVAVA 140
Query: 55 AAGPG 59
AA PG
Sbjct: 141 AAKPG 145
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 28.5 bits (62), Expect = 1.2
Identities = 27/78 (34%), Positives = 33/78 (42%), Gaps = 6/78 (7%)
Query: 2 GLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAK 61
G G EQG+TL RE P A A AAG P GR S+A++ +
Sbjct: 111 GAGRAEQGSTLRRRIREHLLPAVKGPAAASGAAG-GTPPGGRSPDSAPSSSSASSSLSSS 169
Query: 62 PLTAQSPVVPAGRSEREE 79
P Q P P G R+E
Sbjct: 170 P---QPP--PRGDRARDE 182
>gi|153285461 fibroblast growth factor 2 [Homo sapiens]
Length = 288
Score = 28.1 bits (61), Expect = 1.6
Identities = 19/56 (33%), Positives = 21/56 (37%), Gaps = 1/56 (1%)
Query: 2 GLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAG 57
G G G L G R G + A P+ PA R RPG T AAG
Sbjct: 83 GRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPG-PAGTMAAG 137
>gi|239756085 PREDICTED: hypothetical protein [Homo sapiens]
Length = 165
Score = 28.1 bits (61), Expect = 1.6
Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 22 PTEGAEAQAWWAAGPKLCP--AGRQLRPGEKLSTAAAGPGAKPLTAQSP 68
P G + AG L P + R + G + S+ +AGPGA P + P
Sbjct: 104 PAVGRASPGAQGAGGSLAPYSSARVRKSGPQSSSGSAGPGAPPASLPEP 152
>gi|239750614 PREDICTED: hypothetical protein [Homo sapiens]
Length = 165
Score = 28.1 bits (61), Expect = 1.6
Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 22 PTEGAEAQAWWAAGPKLCP--AGRQLRPGEKLSTAAAGPGAKPLTAQSP 68
P G + AG L P + R + G + S+ +AGPGA P + P
Sbjct: 104 PAVGRASPGAQGAGGSLAPYSSARVRKSGPQSSSGSAGPGAPPASLPEP 152
>gi|239744921 PREDICTED: hypothetical protein XP_002343308 [Homo
sapiens]
Length = 165
Score = 28.1 bits (61), Expect = 1.6
Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 22 PTEGAEAQAWWAAGPKLCP--AGRQLRPGEKLSTAAAGPGAKPLTAQSP 68
P G + AG L P + R + G + S+ +AGPGA P + P
Sbjct: 104 PAVGRASPGAQGAGGSLAPYSSARVRKSGPQSSSGSAGPGAPPASLPEP 152
>gi|139394621 chondroitin sulfate proteoglycan 5 (neuroglycan C)
precursor [Homo sapiens]
Length = 539
Score = 28.1 bits (61), Expect = 1.6
Identities = 19/54 (35%), Positives = 22/54 (40%), Gaps = 5/54 (9%)
Query: 15 EAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAKPLTAQSP 68
+ RE P E +A W A P G P E L +AA G L A SP
Sbjct: 58 DTREEAGPPAAGEDEASWTA-----PGGELAGPEEVLQESAAVTGTAWLEADSP 106
>gi|22547197 zinc finger protein of the cerebellum 2 [Homo
sapiens]
Length = 532
Score = 28.1 bits (61), Expect = 1.6
Identities = 13/36 (36%), Positives = 19/36 (52%)
Query: 37 KLCPAGRQLRPGEKLSTAAAGPGAKPLTAQSPVVPA 72
KL P +L PG+ + + GPGA P +A + A
Sbjct: 61 KLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAA 96
>gi|154426272 hypothetical protein LOC54540 [Homo sapiens]
Length = 789
Score = 28.1 bits (61), Expect = 1.6
Identities = 25/75 (33%), Positives = 30/75 (40%), Gaps = 14/75 (18%)
Query: 13 VGEAREAQEPTEGAEAQAWWAAGPKL----------CPAGRQLRPGEKLSTAAAGPGAKP 62
VG EA E + G+ WA PK P + RP E+ S GP A+P
Sbjct: 650 VGSCAEAGEGSRGSRPGPGWAGSPKTEKEKGSSWRNWPGEAKARPQEQESVQPPGP-ARP 708
Query: 63 LTAQSPVVPAGRSER 77
QS GRS R
Sbjct: 709 ---QSLPQGKGRSRR 720
>gi|239756307 PREDICTED: similar to ubiquitin-associated protein 1
(predicted) [Homo sapiens]
Length = 290
Score = 27.7 bits (60), Expect = 2.1
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 15 EAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAK 61
EA + P E E +A ++G + PA L+PG S A+ GPG +
Sbjct: 98 EAGHQERPEEEGEDEAEASSGSEEEPAPSSLQPG---SPASPGPGRR 141
>gi|239755362 PREDICTED: hypothetical protein [Homo sapiens]
Length = 112
Score = 27.7 bits (60), Expect = 2.1
Identities = 18/58 (31%), Positives = 24/58 (41%), Gaps = 1/58 (1%)
Query: 1 MGLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGP 58
MG G +EQ A LV ++ QEP + P L P G +K +GP
Sbjct: 25 MGPGVLEQRAALVRDSTAVQEPRRRGGSGMACCRSPAL-PHGEVAEARQKFQREVSGP 81
>gi|239750857 PREDICTED: similar to ubiquitin-associated protein 1
(predicted) [Homo sapiens]
Length = 290
Score = 27.7 bits (60), Expect = 2.1
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 15 EAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAK 61
EA + P E E +A ++G + PA L+PG S A+ GPG +
Sbjct: 98 EAGHQERPEEEGEDEAEASSGSEEEPAPSSLQPG---SPASPGPGRR 141
>gi|239749695 PREDICTED: hypothetical protein XP_002347121 [Homo
sapiens]
Length = 594
Score = 27.7 bits (60), Expect = 2.1
Identities = 18/45 (40%), Positives = 20/45 (44%)
Query: 2 GLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLR 46
GLG Q VGEAREA E A A +L A Q+R
Sbjct: 353 GLGVSPQAGARVGEAREAVTTHERAHLDREGEARARLGQAAAQMR 397
>gi|239745220 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 27.7 bits (60), Expect = 2.1
Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 3/47 (6%)
Query: 15 EAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAGPGAK 61
EA + P E E +A ++G + PA L+PG S A+ GPG +
Sbjct: 98 EAGHQERPEEEGEDEAEASSGSEEEPAPSSLQPG---SPASPGPGRR 141
>gi|239743961 PREDICTED: hypothetical protein XP_002344246 [Homo
sapiens]
Length = 594
Score = 27.7 bits (60), Expect = 2.1
Identities = 18/45 (40%), Positives = 20/45 (44%)
Query: 2 GLGAVEQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLR 46
GLG Q VGEAREA E A A +L A Q+R
Sbjct: 353 GLGVSPQAGARVGEAREAVTTHERAHLDREGEARARLGQAAAQMR 397
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
Length = 1747
Score = 27.7 bits (60), Expect = 2.1
Identities = 15/39 (38%), Positives = 17/39 (43%)
Query: 38 LCPAGRQLRPGEKLSTAAAGPGAKPLTAQSPVVPAGRSE 76
L P + G L+T AGPG P T SP SE
Sbjct: 1322 LVPPPEEFANGVLLATPLAGPGPSPTTVPSPASGKPSSE 1360
>gi|73476377 LBXCOR1 homolog [Homo sapiens]
Length = 921
Score = 27.7 bits (60), Expect = 2.1
Identities = 22/70 (31%), Positives = 28/70 (40%), Gaps = 1/70 (1%)
Query: 7 EQGATLVGEAREAQEPTEGAEAQAWWAAGPKLCPAGRQLRPGEKLSTAAAG-PGAKPLTA 65
E A G + ++PT A + A GP P G RP +L AG P L A
Sbjct: 635 EPSAPSAGGGPDGEQPTGPPSATSSGADGPANSPDGGSPRPRRRLGPPPAGRPAFGDLAA 694
Query: 66 QSPVVPAGRS 75
+ V RS
Sbjct: 695 EDLVRRPERS 704
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.127 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 3,734,666
Number of Sequences: 37866
Number of extensions: 177895
Number of successful extensions: 865
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 817
Number of HSP's gapped (non-prelim): 106
length of query: 80
length of database: 18,247,518
effective HSP length: 52
effective length of query: 28
effective length of database: 16,278,486
effective search space: 455797608
effective search space used: 455797608
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 55 (25.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.