Guide to the Human Genome
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Search of human proteins with 239747467

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens]
         (654 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens]         1329   0.0  
gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens]         1324   0.0  
gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens]         1320   0.0  
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi...   525   e-149
gi|83281200 protogenin [Homo sapiens]                                 329   4e-90
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [...   244   2e-64
gi|157311649 neogenin homolog 1 [Homo sapiens]                        187   2e-47
gi|110431348 deleted in colorectal carcinoma [Homo sapiens]           174   2e-43
gi|224994173 roundabout 1 isoform d [Homo sapiens]                    142   1e-33
gi|224994171 roundabout 1 isoform c [Homo sapiens]                    142   1e-33
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ...   142   1e-33
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ...   142   1e-33
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                   140   5e-33
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                   140   5e-33
gi|19743806 roundabout 1 isoform b [Homo sapiens]                     139   6e-33
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                   139   6e-33
gi|4506569 roundabout 1 isoform a [Homo sapiens]                      139   6e-33
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...   136   5e-32
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ...   136   7e-32
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...   134   2e-31
gi|109150416 peroxidasin [Homo sapiens]                               127   3e-29
gi|118572606 hemicentin 1 [Homo sapiens]                              122   1e-27
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [...   122   1e-27
gi|126517478 peroxidasin homolog-like [Homo sapiens]                  118   1e-26
gi|15147240 brother of CDO [Homo sapiens]                             117   3e-26
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]        110   3e-24
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]            110   4e-24
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...   107   3e-23
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...   107   3e-23
gi|7657359 contactin 5 isoform long [Homo sapiens]                    107   5e-23

>gi|239747467 PREDICTED: similar to hCG1996527 [Homo sapiens]
          Length = 654

 Score = 1329 bits (3439), Expect = 0.0
 Identities = 654/654 (100%), Positives = 654/654 (100%)

Query: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
           MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA
Sbjct: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60

Query: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH 120
           NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH
Sbjct: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH 120

Query: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
           PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM
Sbjct: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180

Query: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
           GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH
Sbjct: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240

Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
           PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ
Sbjct: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300

Query: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
           GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ
Sbjct: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360

Query: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
           WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED
Sbjct: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420

Query: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
           EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII
Sbjct: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480

Query: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
           GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA
Sbjct: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540

Query: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLRDVP 600
           STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLRDVP
Sbjct: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLRDVP 600

Query: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
           LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS
Sbjct: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654


>gi|169162264 PREDICTED: similar to hCG1996527 [Homo sapiens]
          Length = 654

 Score = 1324 bits (3427), Expect = 0.0
 Identities = 652/654 (99%), Positives = 653/654 (99%)

Query: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
           MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA
Sbjct: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60

Query: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH 120
           NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSR+ARVQLASLSRFHQH
Sbjct: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH 120

Query: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
           PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM
Sbjct: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180

Query: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
           GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH
Sbjct: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240

Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
           PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ
Sbjct: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300

Query: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
           GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ
Sbjct: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360

Query: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
           WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED
Sbjct: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420

Query: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
           EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII
Sbjct: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480

Query: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
           GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA
Sbjct: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540

Query: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLRDVP 600
           STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSL DVP
Sbjct: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP 600

Query: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
           LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS
Sbjct: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654


>gi|239741341 PREDICTED: similar to hCG1996527 [Homo sapiens]
          Length = 654

 Score = 1320 bits (3415), Expect = 0.0
 Identities = 651/654 (99%), Positives = 652/654 (99%)

Query: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
           MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA
Sbjct: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60

Query: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH 120
           NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSR+ARVQLASLSRFHQH
Sbjct: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRQARVQLASLSRFHQH 120

Query: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180
           PESIEVERGGVA FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM
Sbjct: 121 PESIEVERGGVARFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDM 180

Query: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
           GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH
Sbjct: 181 GTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240

Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
           PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ
Sbjct: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300

Query: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360
           GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ
Sbjct: 301 GVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ 360

Query: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420
           WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED
Sbjct: 361 WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVED 420

Query: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480
           EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII
Sbjct: 421 EAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDII 480

Query: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540
           GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA
Sbjct: 481 GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFA 540

Query: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLRDVP 600
           STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSL DVP
Sbjct: 541 STMGSNLGEALNLPVPLKACLSQCDLAPEPAALYDIKLQAFNGNGDGNSSARCVSLCDVP 600

Query: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654
           LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS
Sbjct: 601 LATPDGTVSTESKTGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWRHS 654


>gi|134244585 putative neuronal cell adhesion molecule [Homo
           sapiens]
          Length = 814

 Score =  525 bits (1353), Expect = e-149
 Identities = 313/698 (44%), Positives = 409/698 (58%), Gaps = 107/698 (15%)

Query: 3   LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
           LLLL  P  G    +ELAF  E  D VAV   P+VL C+VEG PPV I+W+++ + L   
Sbjct: 26  LLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES 85

Query: 63  SGVTLMPDGSL---HLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQ 119
           +  TL+ +GSL   H    P     PS   +Y CVAQNR+G +VSR+AR+Q A++S FH 
Sbjct: 86  THSTLLANGSLMIRHFRLEPG--GSPSDEGDYECVAQNRFGLVVSRKARIQAATMSDFHV 143

Query: 120 HPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTD 179
           HP++   E GGVA FQC I G+P+P I+WE N   ++T N R TLLP G+L IT +   D
Sbjct: 144 HPQATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDTDNERYTLLPKGVLQITGLRAED 203

Query: 180 MGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATS 239
            G + CVA N+AS R S  A+LT+S       +EP IL GP+NLTLTVHQTAVLEC+AT 
Sbjct: 204 GGIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATG 263

Query: 240 HPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTA 299
           +P P+VSWSRLDGR IGVEGIQV   L TGNL+ISDV+VQHSGVYVCAANRPGT VRRTA
Sbjct: 264 NPRPIVSWSRLDGRPIGVEGIQV---LGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTA 320

Query: 300 QGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFV 359
           QG L+VQ                                      AP+         EFV
Sbjct: 321 QGRLVVQ--------------------------------------APA---------EFV 333

Query: 360 QWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVE 419
           Q PQS+S+P G++A+FTC AQG P   + WLKNG+VL PG ++RL +NNSTL ++G+  E
Sbjct: 334 QHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGPGGHVRLKNNNSTLTISGIGPE 393

Query: 420 DEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATP-PSSRD 478
           DEAIYQCVAENS GS+QASARL V      P P       S+      V  + P  ++++
Sbjct: 394 DEAIYQCVAENSAGSSQASARLTVLWAEGLPGPPRNVRAVSVSSTEVRVSWSEPLANTKE 453

Query: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
           IIGYVLH+R   +P   E QEA+SK T +H+ S+LEP+TAY+ +++AY+  GAS  S P 
Sbjct: 454 IIGYVLHIRKAADPPELEYQEAVSKSTFQHLVSDLEPSTAYSFYIKAYTPRGASSASVPT 513

Query: 539 FASTMGSN----------LG-EALNL-----------------------------PVPLK 558
            AST+G            LG  +L L                             P+ L 
Sbjct: 514 LASTLGEAPAPPPLSVRVLGSSSLQLLWEPWPRLAQHEGGFKLFYRPASKTSFTGPILLP 573

Query: 559 ACLSQCDLAP-EPAALYDIKLQAFNGNGDGNSSARCVSLRDVPLATPDGTVSTESKTGCS 617
             +S  +L+  +P A+Y++KL A+N +GDGN++ R VSLR         +  T     C 
Sbjct: 574 GTVSSYNLSQLDPTAVYEVKLLAYNQHGDGNATVRFVSLR-------GASERTALSPPCD 626

Query: 618 CSQGES---SPLPGVVVGIHVGLAALIICLLCLFLGWR 652
           C + E+   +   G+V+GIH+G+  +I C+L L  G R
Sbjct: 627 CRKEEAANQTSTTGIVIGIHIGVTCIIFCVLFLLFGQR 664


>gi|83281200 protogenin [Homo sapiens]
          Length = 1150

 Score =  329 bits (844), Expect = 4e-90
 Identities = 199/545 (36%), Positives = 284/545 (52%), Gaps = 58/545 (10%)

Query: 3   LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
           LLLLL P  G    SEL+FV+E  D     + P+VL CQ  GE P+ ++W ++   ++  
Sbjct: 23  LLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMSEN 82

Query: 63  SGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPE 122
             + ++ +GSL+++ +  RR   S    Y C+A N+YG ++S++A + L+++S F   P 
Sbjct: 83  KRIEVLSNGSLYISEVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPI 142

Query: 123 SIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGT 182
           S EV  GGVA F C I   P   I+WE N T L     R+T LP+G+L I  VSQ D G 
Sbjct: 143 STEVHEGGVARFACKISSHPPAVITWEFNRTTLPMTMDRITALPTGVLQIYDVSQRDSGN 202

Query: 183 YRCVAWNVASTRHSQDAQLT-LSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHP 241
           YRC+A  VA  R S +A LT +     +    P I++GPQN+T ++HQT VLEC+AT +P
Sbjct: 203 YRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTSLHQTVVLECMATGNP 262

Query: 242 WPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQG 301
            P++SWSRLD +SI V   +V   L  GNLMISDV +QH+GVYVC A  PGT     A  
Sbjct: 263 KPIISWSRLDHKSIDVFNTRV---LGNGNLMISDVRLQHAGVYVCRATTPGTRNFTVAMA 319

Query: 302 VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQW 361
            L V   P    W                                               
Sbjct: 320 TLTVLAPPSFVEW----------------------------------------------- 332

Query: 362 PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDE 421
           P+SL++P   +A F C A+G+P  ++ WLKNG+ +   +N R+   NS L++  +  ED+
Sbjct: 333 PESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRKIH--SNGRIKMYNSKLVINQIIPEDD 390

Query: 422 AIYQCVAENSTGSNQASARLVVTGGPEPPRPQGP-ACHGSLYFCHSSVLGATPP--SSRD 478
           AIYQC+AENS GS  + ARL V    +  RP  P   H       + +L    P  +S  
Sbjct: 391 AIYQCMAENSQGSILSRARLTVVMSED--RPSAPYNVHAETMSSSAILLAWERPLYNSDK 448

Query: 479 IIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPI 538
           +I Y +H       +  E Q  I   T+ ++  +LEPA+ YT ++ AY   GASQ S  +
Sbjct: 449 VIAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHV 508

Query: 539 FASTM 543
             +T+
Sbjct: 509 TQNTL 513



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 22/81 (27%), Positives = 37/81 (45%), Gaps = 7/81 (8%)

Query: 573 LYDIKLQAFNGNGDGNSSARCVSLRDVPLAT------PDGTVSTESKTGCSCSQGESSPL 626
           +Y +K+ A N  G+G  S   V L  +P  T      P    S ++K        +   +
Sbjct: 890 VYIVKISASNEVGEGPFS-NSVELAVLPKETSESNQRPKRLDSADAKVYSGYYHLDQKSM 948

Query: 627 PGVVVGIHVGLAALIICLLCL 647
            G+ VG+ + L  ++IC+L L
Sbjct: 949 TGIAVGVGIALTCILICVLIL 969


>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
           [Homo sapiens]
          Length = 1250

 Score =  244 bits (622), Expect = 2e-64
 Identities = 177/528 (33%), Positives = 249/528 (47%), Gaps = 71/528 (13%)

Query: 33  EHPLVLPCQVEGE---PPVSISWQRDRLALANESGVTLMPDGSLHL----AALPSRRSLP 85
           E   VL C +      PP  ++W +D   L     + L+P+GSL L    A   S  S+P
Sbjct: 50  EQAAVLNCSLGAAAAGPPTRVTWSKDGDTLLEHDHLHLLPNGSLWLSQPLAPNGSDESVP 109

Query: 86  SRAH----EYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
                    Y C+A    G L S+ A V+LA+L+ F  HPES  VE  G A F+C I+G+
Sbjct: 110 EAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIEGL 169

Query: 142 PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
           P P I+WE +   L     R+ +LP+G+L I  V ++D G YRCVA N A    SQ+A L
Sbjct: 170 PAPIITWEKDQVTL-PEEPRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALL 228

Query: 202 TLS-VGPLRLL--QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
           +++  G L     Q+  I++ P+N T+   Q+ V+EC+A++ P P VSW R DG+ I  +
Sbjct: 229 SVAHRGSLASTRGQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD 288

Query: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
            I    +L   NL+I++    HSGVYVC AN+P T    TA   L             RV
Sbjct: 289 VI----VLGRTNLLIANAQPWHSGVYVCRANKPRTRDFATAAAEL-------------RV 331

Query: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCV 378
           L  P+                                    Q P++LS+   S+A F C 
Sbjct: 332 LAAPA----------------------------------ITQAPEALSRTRASTARFVCR 357

Query: 379 AQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQAS 438
           A G P   L WL NG  L P   +++     +L++  + ++D   YQCVAENS G   A+
Sbjct: 358 ASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAENSAGMACAA 417

Query: 439 ARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGA---TPPSSRDIIGYVLHLRPVGEPSGP 495
           A L V        P  P    +     S+VL A       S  IIG+ LH +        
Sbjct: 418 ASLAVV--VREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLHYQKARGMDNV 475

Query: 496 ELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
           E Q A++  T+E    +LEP T Y  ++ AYS  GAS+ S P    T+
Sbjct: 476 EYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTL 523



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 73/323 (22%), Positives = 127/323 (39%), Gaps = 23/323 (7%)

Query: 16  GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANESGVTLMPDGSLH 74
           G ++  V    +T  V    +V+ C    +P   +SW R D   ++ +  V ++   +L 
Sbjct: 241 GQDVVIVAAPENTTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTD--VIVLGRTNLL 298

Query: 75  LAALPSRRSLPSRAHEYHCVAQNRYGR-LVSRRARVQLASLSRFHQHPESIEVERGGVAC 133
           +A      + P  +  Y C A     R   +  A +++ +     Q PE++   R   A 
Sbjct: 299 IA-----NAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTAR 353

Query: 134 FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           F C   G P P++ W HNG  L            G L IT +   D G Y+CVA N    
Sbjct: 354 FVCRASGEPRPALRWLHNGAPLRPNGRVKVQGGGGSLVITQIGLQDAGYYQCVAEN---- 409

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLT-VHQTAVLEC--IATSHPWPLVSWSRL 250
                A +  +   L ++    + S P  +T T +  +AVL        H   ++ +S  
Sbjct: 410 ----SAGMACAAASLAVVVREGLPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIGFSLH 465

Query: 251 DGRSIGVEGIQVLDIL--DTGNLMISDVSVQHS-GVYVCAANRPGTHVRRTAQGVLLVQG 307
             ++ G++ ++    +  DT  L + D+        YV A ++ G     T   V  +  
Sbjct: 466 YQKARGMDNVEYQFAVNNDTTELQVRDLEPNTDYEFYVVAYSQLGASRTSTPALVHTLDD 525

Query: 308 EPQGPNWVGRVLEHPSSLTGAWI 330
            P     +     +PS +  AW+
Sbjct: 526 VPSAAPQLSLSSPNPSDIRVAWL 548


>gi|157311649 neogenin homolog 1 [Homo sapiens]
          Length = 1461

 Score =  187 bits (476), Expect = 2e-47
 Identities = 150/568 (26%), Positives = 242/568 (42%), Gaps = 112/568 (19%)

Query: 9   PGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDR--LALANESGVT 66
           PG      +   F+ E  DT++V    ++L C    EP   I W++D   L L ++    
Sbjct: 43  PGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQ 102

Query: 67  LMPDGSLHLA-ALPSRRSLPSRAHEYHCVAQ-NRYGRLVSRRARVQLASLSRFHQHPESI 124
           L+PDGSL ++  + S+ + P   + Y CVA     G ++SR A++ +A L RF   PE  
Sbjct: 103 LLPDGSLFISNVVHSKHNKPDEGY-YQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPS 161

Query: 125 EVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYR 184
            V  G  A   C +     P + WE N   L   + RV  LPSG+L I++ ++ D G YR
Sbjct: 162 SVYAGNNAILNCEVNADLVPFVRWEQNRQPL-LLDDRVIKLPSGMLVISNATEGDGGLYR 220

Query: 185 CVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSG------PQNLTLTVHQTAVLECIAT 238
           CV  +    ++S + +       L++L +PE++S       P  L   + Q  VL C+A+
Sbjct: 221 CVVESGGPPKYSDEVE-------LKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVAS 273

Query: 239 SHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRT 298
             P P + W + +  ++  E  + L +L  G+L ISDV+   +G Y C A+     +   
Sbjct: 274 GLPTPTIKWMK-NEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIE-- 330

Query: 299 AQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEF 358
           AQ  L VQ +P                                               EF
Sbjct: 331 AQAELTVQAQP-----------------------------------------------EF 343

Query: 359 VQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSV 418
           ++ P ++        +F C   G P   + W+KNG ++ P +  ++   ++ L + G+  
Sbjct: 344 LKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHN-LQVLGLVK 402

Query: 419 EDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRD 478
            DE  YQC+AEN  G+ QA A+L++           PA  G L           P + RD
Sbjct: 403 SDEGFYQCIAENDVGNAQAGAQLIIL-------EHAPATTGPL-----------PSAPRD 444

Query: 479 IIGYVLHLR--------PVGEPSGPEL-------QEAISK---------GTSEHVFSNLE 514
           ++  ++  R        P  +P G  L       +E I++         G  +    NL 
Sbjct: 445 VVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLM 504

Query: 515 PATAYTIHLRAYSAEGASQDSAPIFAST 542
           PAT Y   + A +  G+ + SAP+   T
Sbjct: 505 PATVYIFRVMAQNKHGSGESSAPLRVET 532



 Score =  103 bits (257), Expect = 5e-22
 Identities = 119/518 (22%), Positives = 206/518 (39%), Gaps = 69/518 (13%)

Query: 37  VLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQ 96
           +L C+V  +    + W+++R  L  +  V  +P G L ++      +       Y CV +
Sbjct: 170 ILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVIS-----NATEGDGGLYRCVVE 224

Query: 97  N----RYGRLVSRRARVQLASLSR--FHQHPESIEVERGGVACFQCLIQGVPEPSISWEH 150
           +    +Y   V  +       +S   F + P  +    G      C+  G+P P+I W  
Sbjct: 225 SGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMK 284

Query: 151 NGTALNT-ANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLR 209
           N  AL+T ++ R+ LL  G L I+ V++ D GTY C+A N   T  +Q A+LT+      
Sbjct: 285 NEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQ-AELTVQA---- 339

Query: 210 LLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
              +PE L  P N+        V EC  T  P P V W +     I  +  +   I+   
Sbjct: 340 ---QPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDYFK---IVKEH 393

Query: 270 NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
           NL +  +     G Y C A     + +  AQ +               +LEH  + TG  
Sbjct: 394 NLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLI---------------ILEHAPATTGPL 438

Query: 330 IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ--WPQSLSKPPGSSAIFTC--VAQGVPES 385
                         +AP  ++       F++  W    S P G +  ++     +G+   
Sbjct: 439 P-------------SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGIARE 485

Query: 386 RLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTG 445
           R+          PG  +++T  N  LM A V      I++ +A+N  GS ++SA L V  
Sbjct: 486 RVE-----NTSHPGE-MQVTIQN--LMPATVY-----IFRVMAQNKHGSGESSAPLRVET 532

Query: 446 GPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGT 505
            PE   P GPA +   Y    + +  T  +     G + + +      G + ++ +   +
Sbjct: 533 QPEVQLP-GPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDKEQDVDVSS 591

Query: 506 SEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
             +  + L+  T Y+  + AY+  G    +  +   T+
Sbjct: 592 HSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTL 629



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 68/325 (20%), Positives = 136/325 (41%), Gaps = 24/325 (7%)

Query: 17  SELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESG--VTLMPDGSLH 74
           S+L F+++    V V    +VLPC   G P  +I W ++  AL  ES   + L+  GSL 
Sbjct: 247 SDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLE 306

Query: 75  LAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACF 134
           ++ +         A  Y C+A N     +  +A + + +   F + P +I         F
Sbjct: 307 ISDVTE-----DDAGTYFCIADNG-NETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVF 360

Query: 135 QCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTR 194
           +C + G P P++ W  NG  +  +++   ++    L +  + ++D G Y+C+A N     
Sbjct: 361 ECEVTGKPTPTVKWVKNGDMVIPSDY-FKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNA 419

Query: 195 HSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECI----ATSHPWPLVSWSRL 250
            +    + L   P      P   S P+++  ++  T  ++      A+      +++S  
Sbjct: 420 QAGAQLIILEHAPATTGPLP---SAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVF 476

Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQ 310
             +  G+   +V +    G + ++  ++  + VY+        H    +   L V+ +P+
Sbjct: 477 YTKE-GIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPE 535

Query: 311 ------GPNWVGRVLEHPSSLTGAW 329
                  PN +      P+S+T  W
Sbjct: 536 VQLPGPAPN-LRAYAASPTSITVTW 559



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 16/166 (9%)

Query: 317 RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQW-----PQSLSKPPGS 371
           R+L  PS      +  G RA G     +  +     A +  F  +     P       GS
Sbjct: 9   RLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGS 68

Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLS-PGNNIRLTHNNSTLMLAGV-----SVEDEAIYQ 425
           S I  C A   P  ++ W K+G  L+   ++ R    + +L ++ V     +  DE  YQ
Sbjct: 69  SVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQ 128

Query: 426 CVA--ENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVL 469
           CVA  E+       +A+L+V G P       P+   S+Y  ++++L
Sbjct: 129 CVATVESLGTIISRTAKLIVAGLPRFTSQPEPS---SVYAGNNAIL 171



 Score = 29.6 bits (65), Expect = 9.2
 Identities = 20/80 (25%), Positives = 41/80 (51%), Gaps = 8/80 (10%)

Query: 466 SSVLGATPPSSRDII--GYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHL 523
           S V+  TPP +++I+  GY +    +G P    ++  +      +   NL+P++ Y I L
Sbjct: 753 SIVVSWTPPENQNIVVRGYAIGYG-IGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITL 809

Query: 524 RAYSAEGASQDSAPIFASTM 543
           +A++  G   +  P++ S +
Sbjct: 810 KAFNNVG---EGIPLYESAV 826


>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
          Length = 1447

 Score =  174 bits (442), Expect = 2e-43
 Identities = 164/571 (28%), Positives = 240/571 (42%), Gaps = 110/571 (19%)

Query: 6   LLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVS-ISWQRD--RLALANE 62
           L + G+   A + L F+ E  D V +    ++L C  E +  V  I W++D   LAL  +
Sbjct: 27  LQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMD 86

Query: 63  SGVTLMPDGSLHLA-ALPSRRSLPSRAHEYHCVAQ-NRYGRLVSRRARVQLASLSRFHQH 120
                + +GSL +   L SR   P     Y C A     G ++SR A+V +A   RF   
Sbjct: 87  ERKQQLSNGSLLIQNILHSRHHKPDEGL-YQCEASLGDSGSIISRTAKVAVAGPLRFLSQ 145

Query: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALN--TANHRVTLLPSGILHITSVSQT 178
            ES+    G     +C + G P P+I W+ N   L     + RV +LPSG L I+ +   
Sbjct: 146 TESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPG 205

Query: 179 DMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIAT 238
           D+G YRC A N AS+R   +A++ +   P  L ++   L  P N+     + AVLEC  +
Sbjct: 206 DIGIYRCSARNPASSRTGNEAEVRILSDP-GLHRQLYFLQRPSNVVAIEGKDAVLECCVS 264

Query: 239 SHPWPLVSWSRLDGRSIGVEGIQV----LDILDTGNLMISDVSVQHSGVYVCAANRPGTH 294
            +P P  +W R      G E IQ+      +L   NL+IS+V+   SG+Y C       +
Sbjct: 265 GYPPPSFTWLR------GEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNEN 318

Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
           +  +A+  +LV      P W    L HPS+                  L A  SM +   
Sbjct: 319 ISASAELTVLV------PPW---FLNHPSN------------------LYAYESMDIE-- 349

Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
                               F C   G P   + W+KNG V+ P +  ++    S L + 
Sbjct: 350 --------------------FECTVSGKPVPTVNWMKNGDVVIPSDYFQIV-GGSNLRIL 388

Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPP 474
           GV   DE  YQCVAEN  G+ Q SA+L+V      P+P  P+         SSVL   P 
Sbjct: 389 GVVKSDEGFYQCVAENEAGNAQTSAQLIV------PKPAIPS---------SSVL---PS 430

Query: 475 SSRDIIGYV-------LHLRPVGEPSG----------------PELQEAISKGTSEHVFS 511
           + RD++  +       L  RP  E  G                         G+ +    
Sbjct: 431 APRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVG 490

Query: 512 NLEPATAYTIHLRAYSAEGASQDSAPIFAST 542
           NL+P   YT  + AY+  G  + S PI  +T
Sbjct: 491 NLKPEAMYTFRVVAYNEWGPGESSQPIKVAT 521


>gi|224994173 roundabout 1 isoform d [Homo sapiens]
          Length = 1551

 Score =  142 bits (358), Expect = 1e-33
 Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)

Query: 22  VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
           V+   D +     P  L C+ EG P  +I W +    +  +     S   L+P GSL  L
Sbjct: 32  VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 76  AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL-SRFHQHPESIEVERGGVACF 134
             +  R+S P     Y CVA+N  G  VS  A +++A L   F Q+P  + V  G  A  
Sbjct: 92  RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150

Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           +C   +G PEP+ISW+ +G+ L+  + R+T+   G L IT   ++D G Y CV  N+   
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
           R S+ A+LT+       L+ P  +  P NL +TV  +A  +C A   P P V W + DG 
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262

Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
                     +I D   L I  V+    G Y C A N  G   +  A   L VQ   + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315

Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
           ++V          GR +      TG    A  WR                 SR    + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375

Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
                              L    S++  A L           P   Q P + +     +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435

Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
            + +CVA G P   ++W K+G ++S  ++      N  L +    + D   Y C+A   +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495

Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
           G    SA + V   G P +PPRP  P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521



 Score =  106 bits (265), Expect = 6e-23
 Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
           R  +HP  + V +G  A   C  +G P P+I W   G  + T      +HR+ LLPSG L
Sbjct: 30  RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88

Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
               +     S+ D G Y CVA N      S +A L +++         +    P ++ +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142

Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
            V + AV+EC     HP P +SW + DG  +  +  ++   +  G LMI+      +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199

Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
           VC                        G N VG      + LT                  
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218

Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
                    + P FV+ P +L+     SA F C A+G P   + W K +G++      IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271

Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
             H   TL +  V+  D   Y CVAEN  G  +ASA L V  G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)

Query: 20  AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
           +FV+   +     +      C+  G+P  ++ W++D   L  +S   +  D +L +    
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278

Query: 80  SRRSLPSRAHEYHCVAQNRYGRL-VSRRARVQLASLS-RFHQHPESIEVERGGVACFQCL 137
            R+        Y CVA+N  G+   S    VQ+ S    F   P    V  G    FQC 
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337

Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
             G P+P+I W   G+           ++ R ++  +G L IT+V ++D+G Y C   NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397

Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
           A +  ++       V   R    P I  GP N T+ V  T VL C+AT  P P + W R 
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454

Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
           DG  +  +  ++   L+ G L I    +  +G Y C A+ P      +A       GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513

Query: 305 VQGEPQGPNWV 315
               P  PN +
Sbjct: 514 QPPRPTDPNLI 524



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)

Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
           P  V+ P  L    G  A   C A+G P   + W K G+ +      P ++  L  + S 
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
             L  V    S  DE +Y CVA N  G   S+ AS  + +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128


>gi|224994171 roundabout 1 isoform c [Homo sapiens]
          Length = 1606

 Score =  142 bits (358), Expect = 1e-33
 Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)

Query: 22  VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
           V+   D +     P  L C+ EG P  +I W +    +  +     S   L+P GSL  L
Sbjct: 32  VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 76  AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL-SRFHQHPESIEVERGGVACF 134
             +  R+S P     Y CVA+N  G  VS  A +++A L   F Q+P  + V  G  A  
Sbjct: 92  RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150

Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           +C   +G PEP+ISW+ +G+ L+  + R+T+   G L IT   ++D G Y CV  N+   
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
           R S+ A+LT+       L+ P  +  P NL +TV  +A  +C A   P P V W + DG 
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262

Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
                     +I D   L I  V+    G Y C A N  G   +  A   L VQ   + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315

Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
           ++V          GR +      TG    A  WR                 SR    + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375

Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
                              L    S++  A L           P   Q P + +     +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435

Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
            + +CVA G P   ++W K+G ++S  ++      N  L +    + D   Y C+A   +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495

Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
           G    SA + V   G P +PPRP  P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521



 Score =  106 bits (265), Expect = 6e-23
 Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
           R  +HP  + V +G  A   C  +G P P+I W   G  + T      +HR+ LLPSG L
Sbjct: 30  RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88

Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
               +     S+ D G Y CVA N      S +A L +++         +    P ++ +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142

Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
            V + AV+EC     HP P +SW + DG  +  +  ++   +  G LMI+      +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199

Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
           VC                        G N VG      + LT                  
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218

Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
                    + P FV+ P +L+     SA F C A+G P   + W K +G++      IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271

Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
             H   TL +  V+  D   Y CVAEN  G  +ASA L V  G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)

Query: 20  AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
           +FV+   +     +      C+  G+P  ++ W++D   L  +S   +  D +L +    
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278

Query: 80  SRRSLPSRAHEYHCVAQNRYGRL-VSRRARVQLASLS-RFHQHPESIEVERGGVACFQCL 137
            R+        Y CVA+N  G+   S    VQ+ S    F   P    V  G    FQC 
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337

Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
             G P+P+I W   G+           ++ R ++  +G L IT+V ++D+G Y C   NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397

Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
           A +  ++       V   R    P I  GP N T+ V  T VL C+AT  P P + W R 
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454

Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
           DG  +  +  ++   L+ G L I    +  +G Y C A+ P      +A       GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513

Query: 305 VQGEPQGPNWV 315
               P  PN +
Sbjct: 514 QPPRPTDPNLI 524



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)

Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
           P  V+ P  L    G  A   C A+G P   + W K G+ +      P ++  L  + S 
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
             L  V    S  DE +Y CVA N  G   S+ AS  + +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128


>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
           sapiens]
          Length = 1562

 Score =  142 bits (358), Expect = 1e-33
 Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)

Query: 22  VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
           V+   D +     P  L C+ EG P  +I W +    +  +     S   L+P GSL  L
Sbjct: 32  VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 76  AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL-SRFHQHPESIEVERGGVACF 134
             +  R+S P     Y CVA+N  G  VS  A +++A L   F Q+P  + V  G  A  
Sbjct: 92  RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150

Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           +C   +G PEP+ISW+ +G+ L+  + R+T+   G L IT   ++D G Y CV  N+   
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
           R S+ A+LT+       L+ P  +  P NL +TV  +A  +C A   P P V W + DG 
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262

Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
                     +I D   L I  V+    G Y C A N  G   +  A   L VQ   + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315

Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
           ++V          GR +      TG    A  WR                 SR    + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375

Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
                              L    S++  A L           P   Q P + +     +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435

Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
            + +CVA G P   ++W K+G ++S  ++      N  L +    + D   Y C+A   +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495

Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
           G    SA + V   G P +PPRP  P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521



 Score =  106 bits (265), Expect = 6e-23
 Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
           R  +HP  + V +G  A   C  +G P P+I W   G  + T      +HR+ LLPSG L
Sbjct: 30  RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88

Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
               +     S+ D G Y CVA N      S +A L +++         +    P ++ +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142

Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
            V + AV+EC     HP P +SW + DG  +  +  ++   +  G LMI+      +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199

Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
           VC                        G N VG      + LT                  
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218

Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
                    + P FV+ P +L+     SA F C A+G P   + W K +G++      IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271

Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
             H   TL +  V+  D   Y CVAEN  G  +ASA L V  G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)

Query: 20  AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
           +FV+   +     +      C+  G+P  ++ W++D   L  +S   +  D +L +    
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278

Query: 80  SRRSLPSRAHEYHCVAQNRYGRL-VSRRARVQLASLS-RFHQHPESIEVERGGVACFQCL 137
            R+        Y CVA+N  G+   S    VQ+ S    F   P    V  G    FQC 
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337

Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
             G P+P+I W   G+           ++ R ++  +G L IT+V ++D+G Y C   NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397

Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
           A +  ++       V   R    P I  GP N T+ V  T VL C+AT  P P + W R 
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454

Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
           DG  +  +  ++   L+ G L I    +  +G Y C A+ P      +A       GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513

Query: 305 VQGEPQGPNWV 315
               P  PN +
Sbjct: 514 QPPRPTDPNLI 524



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)

Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
           P  V+ P  L    G  A   C A+G P   + W K G+ +      P ++  L  + S 
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
             L  V    S  DE +Y CVA N  G   S+ AS  + +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128


>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
           sapiens]
          Length = 1615

 Score =  142 bits (358), Expect = 1e-33
 Identities = 140/506 (27%), Positives = 206/506 (40%), Gaps = 88/506 (17%)

Query: 22  VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
           V+   D +     P  L C+ EG P  +I W +    +  +     S   L+P GSL  L
Sbjct: 32  VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 76  AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL-SRFHQHPESIEVERGGVACF 134
             +  R+S P     Y CVA+N  G  VS  A +++A L   F Q+P  + V  G  A  
Sbjct: 92  RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150

Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           +C   +G PEP+ISW+ +G+ L+  + R+T+   G L IT   ++D G Y CV  N+   
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
           R S+ A+LT+       L+ P  +  P NL +TV  +A  +C A   P P V W + DG 
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262

Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
                     +I D   L I  V+    G Y C A N  G   +  A   L VQ   + P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQVGSEPP 315

Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
           ++V          GR +      TG    A  WR                 SR    + G
Sbjct: 316 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375

Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
                              L    S++  A L           P   Q P + +     +
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 435

Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
            + +CVA G P   ++W K+G ++S  ++      N  L +    + D   Y C+A   +
Sbjct: 436 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 495

Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
           G    SA + V   G P +PPRP  P
Sbjct: 496 GEATWSAYIEVQEFGVPVQPPRPTDP 521



 Score =  106 bits (265), Expect = 6e-23
 Identities = 98/347 (28%), Positives = 140/347 (40%), Gaps = 73/347 (21%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
           R  +HP  + V +G  A   C  +G P P+I W   G  + T      +HR+ LLPSG L
Sbjct: 30  RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88

Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
               +     S+ D G Y CVA N      S +A L +++         +    P ++ +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142

Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
            V + AV+EC     HP P +SW + DG  +  +  ++   +  G LMI+      +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199

Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
           VC                        G N VG      + LT                  
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218

Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
                    + P FV+ P +L+     SA F C A+G P   + W K +G++      IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271

Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
             H   TL +  V+  D   Y CVAEN  G  +ASA L V  G EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPP 315



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 84/311 (27%), Positives = 131/311 (42%), Gaps = 25/311 (8%)

Query: 20  AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
           +FV+   +     +      C+  G+P  ++ W++D   L  +S   +  D +L +    
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278

Query: 80  SRRSLPSRAHEYHCVAQNRYGRL-VSRRARVQLASLS-RFHQHPESIEVERGGVACFQCL 137
            R+        Y CVA+N  G+   S    VQ+ S    F   P    V  G    FQC 
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCE 337

Query: 138 IQGVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNV 190
             G P+P+I W   G+           ++ R ++  +G L IT+V ++D+G Y C   NV
Sbjct: 338 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 397

Query: 191 ASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRL 250
           A +  ++       V   R    P I  GP N T+ V  T VL C+AT  P P + W R 
Sbjct: 398 AGSIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RK 454

Query: 251 DGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLL 304
           DG  +  +  ++   L+ G L I    +  +G Y C A+ P      +A       GV +
Sbjct: 455 DGVLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPV 513

Query: 305 VQGEPQGPNWV 315
               P  PN +
Sbjct: 514 QPPRPTDPNLI 524



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)

Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
           P  V+ P  L    G  A   C A+G P   + W K G+ +      P ++  L  + S 
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
             L  V    S  DE +Y CVA N  G   S+ AS  + +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score =  140 bits (352), Expect = 5e-33
 Identities = 129/462 (27%), Positives = 195/462 (42%), Gaps = 63/462 (13%)

Query: 30   AVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
            AV E  ++LPC+  G P  +I+WQ++ L +A      ++P G L +A      + P  A 
Sbjct: 2768 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIA-----HASPEDAG 2822

Query: 90   EYHCVAQNRYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISW 148
             Y C+A+N  G  + + R  VQ+  +         +    G  A   C  +G PEP+I+W
Sbjct: 2823 NYLCIAKNSAGSAMGKTRLVVQVPPV--IENGLPDLSTTEGSHAFLPCKARGSPEPNITW 2880

Query: 149  EHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPL 208
            + +G  ++ A  + T+ PSG L + ++   D GTY C A N A  R  +   LT+ V P+
Sbjct: 2881 DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRRVHLTILVLPV 2939

Query: 209  RLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
                     + P + +L +     L C A   P P + W+ ++ R +  EG+   D    
Sbjct: 2940 -------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSEQD--GG 2988

Query: 269  GNLMISDVSVQHSGVYVC-AANRPG-------THVRR------------------TAQGV 302
              L  + VS + SG YVC A NR G        HV+                   + Q  
Sbjct: 2989 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLD 3048

Query: 303  LLVQGEP-QGPNWV-------GRVLEHPSSLTGAWIWRGSRAGGKR--------LGLTAP 346
             +V+G+P    +W+       G  L H        I R  R    R        +G+   
Sbjct: 3049 CVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 3108

Query: 347  SSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTH 406
              +L+    P F   PQ ++   G      C A G P   + WL+ G+ L     +R T 
Sbjct: 3109 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR-TL 3167

Query: 407  NNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
             + +L L  V   D   Y CVA N  GS  A A LVV G P+
Sbjct: 3168 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3209



 Score =  139 bits (350), Expect = 8e-33
 Identities = 149/545 (27%), Positives = 216/545 (39%), Gaps = 72/545 (13%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGS-LHLAALPSRRSLPSRAHEYHCV 94
            LVL C VE EP   I+W RD + L  ++       G  L L AL +  S      +Y C 
Sbjct: 2408 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-----GDYSCT 2462

Query: 95   AQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTA 154
            A+N  G   S   RV++ ++      P ++ V     A   C   GVP P +SW  +   
Sbjct: 2463 ARNAAGS-TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2521

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA-STRHSQDAQLTLSVGPLRLLQE 213
            L+  + R  +LP G L I  V   D G Y C+A N A S R  +D         LR+L+ 
Sbjct: 2522 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD---------LRVLEP 2572

Query: 214  PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ-VLDILDTGNLM 272
            P I   P NLTLT H  A+L C A+  P PLV W + DG+ +     Q    +L +  L+
Sbjct: 2573 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALL 2631

Query: 273  ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ---GEPQGPNWVGRVLE-----HPSS 324
            ++    Q S  + C  +       R  Q  + V     + Q    V  +       H + 
Sbjct: 2632 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2691

Query: 325  L---TGAWIWRGSRAGGKRLGL-TAPSSMLLPAQL------------------------- 355
            +   T +W   G++ G +  G   +PS  L   Q                          
Sbjct: 2692 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2751

Query: 356  -----PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNST 410
                 P     P  +        +  C A G+P   + W K G  ++ G + ++      
Sbjct: 2752 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ- 2810

Query: 411  LMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP--EPPRPQGPACHGSLYFCHSSV 468
            L +A  S ED   Y C+A+NS GS     RLVV   P  E   P      GS  F     
Sbjct: 2811 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2870

Query: 469  LGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSA 528
             G+  P+    I +    +PV   SG E +  I + + E +  NLE   A T    A +A
Sbjct: 2871 RGSPEPN----ITWDKDGQPV---SGAEGKFTI-QPSGELLVKNLEGQDAGTYTCTAENA 2922

Query: 529  EGASQ 533
             G ++
Sbjct: 2923 VGRAR 2927



 Score =  108 bits (270), Expect = 2e-23
 Identities = 139/603 (23%), Positives = 215/603 (35%), Gaps = 99/603 (16%)

Query: 24  ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
           E G+   + +H + L C+  G P  +I+W +D   L   + V     G      L   R+
Sbjct: 317 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR----QLQLGRA 372

Query: 84  LPSRAHEYHCVAQNRYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACFQCLIQG 140
             S A  Y C A N  G    +  R+ +    ++      P  ++   G     +C+ +G
Sbjct: 373 QSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431

Query: 141 VPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQ 200
            P P++SW H G  +  +N         +L + S  +   G Y CVA + A     Q   
Sbjct: 432 HPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YS 490

Query: 201 LTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
           + + V P  L+ E     G   +T  V Q   L C A+  P P + W +    +  + G+
Sbjct: 491 VEVQVPPQLLVAE-----GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 545

Query: 261 QVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
           QV     T  L I  V + HSG++ C A N  GT     A+  + V GE     W   VL
Sbjct: 546 QVASQGTT--LHIDHVELDHSGLFACQATNEAGT---AGAEVEVSVHGE-----WAPGVL 595

Query: 320 -----------EHPSSLTGA--------------------WIWRGSRAGGKRLGLTAPSS 348
                      EH SS   A                    W   GS   G+  G+    S
Sbjct: 596 EVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 654

Query: 349 MLLPAQL---------------------------------PEFVQWPQSLSKPPGSSAIF 375
           +  P Q+                                 P     P + +    +S   
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTL 714

Query: 376 TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
            C+A GVP   + W K  + +S    + ++ +   L +    + D   Y+CVA N  GS 
Sbjct: 715 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 774

Query: 436 QASARLVVTGGPE---PPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEP 492
           +    L V   P    PP   GP    +      +  GA  P+    + ++    PV   
Sbjct: 775 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT----LMWLKDGNPVSPA 830

Query: 493 SGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTMGSNLGEALN 552
             P LQ  +  G      ++   + +      A SA G  +    +      S LGE LN
Sbjct: 831 GTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN 888

Query: 553 LPV 555
           + V
Sbjct: 889 VSV 891



 Score =  107 bits (267), Expect = 3e-23
 Identities = 113/408 (27%), Positives = 165/408 (40%), Gaps = 85/408 (20%)

Query: 35   PLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
            P+ L C  +G P  +I+W +D  AL      T + + S     L  R      A  Y C+
Sbjct: 2321 PMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRVLRVRD-----AGLYTCL 2369

Query: 95   AQNRYGRLV-SRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGT 153
            A++  G +  S R RVQ        + P  +     G    +C ++  P P I+W  +G 
Sbjct: 2370 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGI 2429

Query: 154  ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQE 213
             L    H         L + ++S  D G Y C A N A +        T     + +   
Sbjct: 2430 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS--------TSVAFRVEIHTV 2481

Query: 214  PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSR----LDGRSIGVEGIQVLDILDTG 269
            P I SGP  + ++V+QTA+L C A   P PLVSW +    LD RS   E      IL  G
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE------ILPEG 2535

Query: 270  NLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
            +L I  V  Q +G Y+C A+N  G+              + QG +   RVLE P+     
Sbjct: 2536 SLRIQPVLAQDAGHYLCLASNSAGS--------------DRQGRDL--RVLEPPAI---- 2575

Query: 329  WIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLV 388
                            +PS++ L A  P                A+  C A G P+  +V
Sbjct: 2576 --------------APSPSNLTLTAHTP----------------ALLPCEASGSPKPLVV 2605

Query: 389  WLKNGKVLS---PGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
            W K+G+ L         RL  +N+ L+L     +D A ++CV  N  G
Sbjct: 2606 WWKDGQKLDFRLQQGAYRLLPSNA-LLLTAPGPQDSAQFECVVSNEVG 2652



 Score =  102 bits (254), Expect = 1e-21
 Identities = 113/458 (24%), Positives = 163/458 (35%), Gaps = 64/458 (13%)

Query: 35   PLVLPCQVEGEPPVSISWQRDRLAL---ANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
            P +LPC+  G P   + W +D   L     +    L+P  +L L A P     P  + ++
Sbjct: 2589 PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTA-PG----PQDSAQF 2643

Query: 92   HCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHN 151
             CV  N  G    R  +V +              V         C   G+P P++SW   
Sbjct: 2644 ECVVSNEVGE-AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2702

Query: 152  GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
            G  L        + PSG L I        G Y C A N A   H +   LT+   P+   
Sbjct: 2703 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASPV--- 2758

Query: 212  QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
                +   P  +     +  +L C A+  P P ++W + +G ++   G+    +L  G L
Sbjct: 2759 ----VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK-EGLNVAT-GVST-QVLPGGQL 2811

Query: 272  MISDVSVQHSGVYVC-AANRPGTHVRRTAQGV----LLVQGEPQGPNWVGRVLEHPSSLT 326
             I+  S + +G Y+C A N  G+ + +T   V    ++  G P      G     P    
Sbjct: 2812 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 2871

Query: 327  GA------WIWRGSRAGGKRLGLT-APSSMLLPAQ------------------------- 354
            G+      W   G    G     T  PS  LL                            
Sbjct: 2872 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2931

Query: 355  -----LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNS 409
                 LP F   P   S   G      C A+G P  R+ W  N + ++ G  +      S
Sbjct: 2932 LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQDGGS 2989

Query: 410  TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
            TL  A VS ED   Y C AEN  G  QA + + V   P
Sbjct: 2990 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 3027



 Score =  102 bits (253), Expect = 1e-21
 Identities = 109/416 (26%), Positives = 162/416 (38%), Gaps = 66/416 (15%)

Query: 23   QELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRR 82
            +EL  +V   E  + L CQ    PP  +SW +D   L    GV L  D +L    L   R
Sbjct: 885  EELNVSVVANES-VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL----LQVDR 939

Query: 83   SLPSRAHEYHCVAQNRYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
            +    A  Y C A N+ GR        V +A +    +   ++ V  G      C  +GV
Sbjct: 940  ADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRES-HTLTVREGHPTSLSCECRGV 998

Query: 142  PEPSISWEHNGTAL--NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
            P P ISW  +G  L    A  +       +L++        GTY C   NV     SQD 
Sbjct: 999  PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG-NSSQDL 1057

Query: 200  QLTLSVGP-LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
            QL + V P +   +EP     P  +++     A LEC AT  P P V+W R DG+ +G E
Sbjct: 1058 QLEVHVPPQIAGPREP-----PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAE 1111

Query: 259  -GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGR 317
             G+Q+ +     +L +      H+G Y C A        R  +  +LV  E  G      
Sbjct: 1112 LGLQLQN--QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD----- 1164

Query: 318  VLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTC 377
             L+  +++T A              L +P ++L                          C
Sbjct: 1165 -LDPLTNITAA--------------LHSPLTLL--------------------------C 1183

Query: 378  VAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
             A G+P   + W +  + +SPG +  L      L +     +D  +Y C+A N  G
Sbjct: 1184 EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 1239



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 138/552 (25%), Positives = 200/552 (36%), Gaps = 95/552 (17%)

Query: 24   ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
            +L    A+    + LPC V   P   ++W +D  AL+    V L+P        L   R+
Sbjct: 1752 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH----TLQLGRA 1807

Query: 84   LPSRAHEYHCVAQNRYGRLVSRRARVQLASL--SRFHQHP----ESIEVERGGVACFQCL 137
              S +  Y C A N  GR    +  VQL+ L    F Q P    +++ V  G  A   C 
Sbjct: 1808 RLSDSGMYTCEALNAAGR---DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 1864

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
               +PEP+++W  +G  L  A     L     L I     +D G Y C   NVA      
Sbjct: 1865 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG----- 1919

Query: 198  DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA----VLECIATSHPWPLVSW--SRLD 251
            +A  T ++     +Q P     P+  T TV Q A    VL C  +  P P V+W   R+ 
Sbjct: 1920 EAVRTFTL----TVQVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 1973

Query: 252  GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
              S  V G+    +   G L +S +    +G Y C A       R+     +LV    + 
Sbjct: 1974 VESSAVHGV----VSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS 2029

Query: 312  PNWV-------GRVLEHPSSLTG------AWIWRGSRAG---GKRL------------GL 343
                       G+ +       G      AW+  GS  G   G  L            GL
Sbjct: 2030 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGL 2089

Query: 344  TAPS---------------------SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
             A                       ++L+P  + +      +L   PG      C  +G 
Sbjct: 2090 RASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 2149

Query: 383  PESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
            P   + WLK+G  L       L  +  TL ++ V + D  I+ CVA +  G    +  L 
Sbjct: 2150 PPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 2209

Query: 443  VTGGP--EPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPS---GP 495
            V   P  EP   Q       GSL        G   P    ++ ++    P+   S   GP
Sbjct: 2210 VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP----LVSWMKDGEPLLSQSLEQGP 2265

Query: 496  ELQ-EAISKGTS 506
             LQ EA+  G S
Sbjct: 2266 SLQLEAVGAGDS 2277



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 112/426 (26%), Positives = 167/426 (39%), Gaps = 82/426 (19%)

Query: 38   LPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAHEYHCV 94
            L C+ +G+PP  ++W +D   L  + G  L   +  GSL L  L +     S A  Y CV
Sbjct: 2046 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA-----SDAGAYTCV 2100

Query: 95   AQNRYGRLVSRRARVQLASLSRFHQHPE---SIEVERGGVACFQCLIQGVPEPSISWEHN 151
            A N  G   +R   V +       Q  +   ++    G +    C ++G P   +SW  +
Sbjct: 2101 AHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 2159

Query: 152  GTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
            G  L   + R  L  SG  L I+ V   D G + CVA   AS     D   TL V    +
Sbjct: 2160 GLPL-PLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGVADRNFTLQVQVPPV 2215

Query: 211  LQEPEILSGPQNLTLTVHQTAV-LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
            L+  E     QN  + V  + V L C A   P PLVSW + DG  +  + ++        
Sbjct: 2216 LEPVEF----QNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLE-----QGP 2265

Query: 270  NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
            +L +  V    SG Y C A       RR  Q                             
Sbjct: 2266 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------------------------- 2296

Query: 330  IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
                              +++ P  + +  Q P  LS  PG+     C AQG P+  + W
Sbjct: 2297 -----------------LTVMEPPHIEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITW 2338

Query: 390  LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
             K+G+ L+     RL +N+    +  + V D  +Y C+AE+  G+ + S R+ V   P  
Sbjct: 2339 HKDGQALT-----RLENNSRATRV--LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI 2391

Query: 450  PRPQGP 455
              P+GP
Sbjct: 2392 VGPRGP 2397



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 131/596 (21%), Positives = 217/596 (36%), Gaps = 88/596 (14%)

Query: 31   VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
            V  +P  L C     PP  ++W R+   L+    V+++  G   +  +P  R+    A  
Sbjct: 1572 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRA--ENAGR 1627

Query: 91   YHCVAQNRYGRLVSRRARVQLAS---LSRFHQHPESIEVERGGVACFQCLIQGVPEPSIS 147
            Y C A N  G        + L     L    +  E + V        QC   G P P+IS
Sbjct: 1628 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1687

Query: 148  WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
            W  NG   + +     L    +L +++    D  +Y CVA N A    S +   TL V  
Sbjct: 1688 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG---SAEKLFTLRV-- 1742

Query: 208  LRLLQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDI 265
                Q P  ++G   + +T  ++ +  L C   +HP P V+W + D +++ + G +V  +
Sbjct: 1743 ----QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK-DSQALSL-GEEVFLL 1796

Query: 266  LDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLV----QGEPQGPNWVGRVLEH 321
              T  L +    +  SG+Y C A       ++  Q  +LV    +  P+GP     V   
Sbjct: 1797 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1856

Query: 322  PSSL-----------TGAWIWRG----------SRAGGKRLGL----------------- 343
              ++           T  W   G          +  GG+RL +                 
Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 1916

Query: 344  ---TAPSSMLLPAQLPEFVQWP--QSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
                A  +  L  Q+P   + P  +++S+  GS  + TC   GVP   + WLK+   +  
Sbjct: 1917 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1976

Query: 399  GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPA-- 456
                 +      L L+ +       Y CVAEN+    +    + V   P   R  G A  
Sbjct: 1977 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-IRSSGVARE 2035

Query: 457  ---CHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNL 513
                 G          G  PP     + ++    P+G+  GP L+  +  G+        
Sbjct: 2036 HHVLEGQEVRLDCEADGQPPPD----VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 2091

Query: 514  EPATAYTIHLRAYSAEGASQDSAPIF-----------ASTMGSNLGEALNLPVPLK 558
              A AYT      + E A   +  +            + T+ S  GE + +  P++
Sbjct: 2092 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVR 2147



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 119/494 (24%), Positives = 190/494 (38%), Gaps = 100/494 (20%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            + L C   G PP  +SW +    +++  GVT+  DG +    L   ++  S A  Y CVA
Sbjct: 712  VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVA 767

Query: 96   QN-------RYGRLVSRRARVQLASLSRFHQHPESIE--VERGGVACFQCLIQGVPEPSI 146
             N       RYG  V+   R+ L         P S+   V         C   G P P++
Sbjct: 768  SNVAGSTELRYGLRVNVPPRITL---------PPSLPGPVLVNTPVRLTCNATGAPSPTL 818

Query: 147  SWEHNGTALNTANHR-VTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
             W  +G  ++ A    + + P G +L + S   +D G Y CVA +       +D Q  + 
Sbjct: 819  MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVV- 873

Query: 205  VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE-GIQVL 263
               L++   P IL    N+++  +++  LEC + + P P++SW + DGR +    G+ + 
Sbjct: 874  ---LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLEPRPGVHL- 928

Query: 264  DILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPS 323
               D   L +    V  +G Y C A                        N  GR  +H +
Sbjct: 929  -SADKALLQVDRADVWDAGHYTCEA-----------------------LNQAGRSEKHYN 964

Query: 324  SLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVP 383
                 W+              AP   L  +          +L+   G     +C  +GVP
Sbjct: 965  --LNVWV--------------APVFPLRES---------HTLTVREGHPTSLSCECRGVP 999

Query: 384  ESRLVWLKNGKVLSPGNNIRLTHNNST---LMLAGVSVEDEAIYQCVAENSTGSNQASAR 440
              ++ W K+G+ L PG    L H ++    L L    +  E  Y C   N  G++    +
Sbjct: 1000 FPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQ 1058

Query: 441  LVV-----TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGP 495
            L V       GP  P  Q       +     +  G  PP+    + +    +PVG   G 
Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT----VTWERDGQPVGAELGL 1114

Query: 496  ELQEAISKGTSEHV 509
            +LQ   ++G S HV
Sbjct: 1115 QLQ---NQGQSLHV 1125



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 95/421 (22%), Positives = 156/421 (37%), Gaps = 68/421 (16%)

Query: 34   HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP----SRAH 89
            HP  L C+  G P   ISW++D   L  E        G  H++A+     L     ++  
Sbjct: 987  HPTSLSCECRGVPFPKISWRKDGQPLPGEGA------GLQHVSAVGRLLYLGQAQLAQEG 1040

Query: 90   EYHCVAQNRYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSI 146
             Y C   N  G   S+  ++++     ++   + P  + V + GVA  +C   G P P++
Sbjct: 1041 TYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTV 1099

Query: 147  SWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVG 206
            +WE +G  +              LH+        G Y CVA N+A  R  +  +L++ V 
Sbjct: 1100 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELSVLVP 1158

Query: 207  PLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDIL 266
            P  L+ + + L+   N+T  +H    L C A   P P + W R  G      G     + 
Sbjct: 1159 P-ELIGDLDPLT---NITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLA 1212

Query: 267  DTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
                L ++    Q SG+Y C A+      RR               N+   VL  PS   
Sbjct: 1213 GGWMLKMTQTQEQDSGLYSCLASNEAGEARR---------------NFSVEVLVPPSI-- 1255

Query: 327  GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
                                          E     + +    G +A   C   G P+ +
Sbjct: 1256 ------------------------------ENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1285

Query: 387  LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
            L W K+G+ L+ G+   ++ +   L +   ++     Y C+A N+ G      +L V   
Sbjct: 1286 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 1345

Query: 447  P 447
            P
Sbjct: 1346 P 1346



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 101/415 (24%), Positives = 163/415 (39%), Gaps = 83/415 (20%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            + + C V G PP+ +SW +D L L       L   GS H   + S+  L + A  + CVA
Sbjct: 2140 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL--HGSGHTLRI-SKVQL-ADAGIFTCVA 2195

Query: 96   QNRYGRLVSRR---ARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNG 152
             +  G  V+ R    +VQ+  +    +    + V RG +    C  +GVP P +SW  +G
Sbjct: 2196 ASPAG--VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDG 2253

Query: 153  TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA--STRHSQDAQLTLSVGPLRL 210
              L +     +L     L + +V   D GTY CVA + A  + RH Q          L +
Sbjct: 2254 EPLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------LTV 2299

Query: 211  LQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
            ++ P I     P  L+LT      L C A   P P ++W + DG        Q L  L+ 
Sbjct: 2300 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG--------QALTRLEN 2350

Query: 269  GNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
             +     + V+ +G+Y C A  P   + ++                              
Sbjct: 2351 NSRATRVLRVRDAGLYTCLAESPAGAIEKSF----------------------------- 2381

Query: 329  WIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLV 388
                       R+ + AP +++ P + P FV     +   PG   +  C  +  P  ++ 
Sbjct: 2382 -----------RVRVQAPPNIVGP-RGPRFV-----VGLAPG-QLVLECSVEAEPAPKIT 2423

Query: 389  WLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            W ++G VL    + +       L L  +S  D   Y C A N+ GS   + R+ +
Sbjct: 2424 WHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2478



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 111/460 (24%), Positives = 174/460 (37%), Gaps = 81/460 (17%)

Query: 16   GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHL 75
            G+E +  +E+  TV    +P+ L C+    P  +I+W +D         + L+P G+  L
Sbjct: 1351 GAEDSADEEVTVTV---NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP-GTHGL 1406

Query: 76   AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHP------ESIEVERG 129
              L +++     A +Y CV  N  G  V       L   S     P      + ++ +  
Sbjct: 1407 QILNAQKE---DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 1463

Query: 130  GVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
                 +C    VP P+I W  +G  +  ++    L    +L I     +D G Y CVA N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523

Query: 190  VASTRHSQDAQLTLSVGPL------------RLLQEPEILSG-PQNLTLTVHQTAVLECI 236
            VA     QD  + + V P+             L +E E   G  +   +  +  A L C 
Sbjct: 1524 VAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1582

Query: 237  ATSHPWPLVSWSRLD-GRSIGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTH 294
              + P P ++W R D   S G E    + +L  G  L I  V  +++G Y C A+     
Sbjct: 1583 TNAIPPPDLTWYREDQPLSAGDE----VSVLQGGRVLQIPLVRAENAGRYSCKAS----- 1633

Query: 295  VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
                            G +W+   L                     L LT P   ++   
Sbjct: 1634 -------------NEVGEDWLHYEL---------------------LVLTPP---VILGD 1656

Query: 355  LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
              E V   + ++    S+    C A G P   + WL+NG   SP   +++  +   L ++
Sbjct: 1657 TEELV---EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 1713

Query: 415  GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQG 454
               V D A Y CVAEN  GS   + +L       PPR  G
Sbjct: 1714 TAEVADAASYMCVAENQAGS---AEKLFTLRVQVPPRIAG 1750



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 99/437 (22%), Positives = 161/437 (36%), Gaps = 78/437 (17%)

Query: 25   LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
            L +  A    PL L C+  G PP +I W R    ++      L+  G +    L   ++ 
Sbjct: 1168 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM----LKMTQTQ 1223

Query: 85   PSRAHEYHCVAQNRYGRLVSRR---ARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
               +  Y C+A N  G   +RR     V +          E I+V  G  A   C + G 
Sbjct: 1224 EQDSGLYSCLASNEAGE--ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGH 1281

Query: 142  PEPSISWEHNGTAL--NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVA--STRHS 196
            P+P ++W  +G  L    A+H   + P G+ L +   + +  G Y C+A N     T+H 
Sbjct: 1282 PQPKLTWFKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHF 1338

Query: 197  QDAQLTLSVGPLRLLQEPEILSGPQN-----LTLTVHQTAVLECIATSHPWPLVSWSRLD 251
            Q          L +L  P IL G ++     +T+TV+    L C A + P P ++W +  
Sbjct: 1339 Q----------LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG 1388

Query: 252  GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQ 310
                    IQ+L    T  L I +   + +G Y C   N  G  V+     VL+      
Sbjct: 1389 APFEASRNIQLLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI------ 1440

Query: 311  GPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPG 370
                                               P S+     L E     + +     
Sbjct: 1441 -----------------------------------PPSISKDDPLGEV--GVKEVKTKVN 1463

Query: 371  SSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAEN 430
            S+    C +  VP   + W K+G+ ++P + +++      L +    V D   Y CVA N
Sbjct: 1464 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1523

Query: 431  STGSNQASARLVVTGGP 447
              G +     +++   P
Sbjct: 1524 VAGEDDQDFNVLIQVPP 1540



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 81/278 (29%), Positives = 115/278 (41%), Gaps = 24/278 (8%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            L L C   G P   I W  +   +    GV+    GS    A  SR      +  Y C A
Sbjct: 2955 LWLRCAARGSPTPRIGWTVNDRPVTE--GVSEQDGGSTLQRAAVSRED----SGTYVCWA 3008

Query: 96   QNRYGRLVSRRARVQLASLSRFHQHPESIEVER-GGVACFQCLIQGVPEPSISWEHNGTA 154
            +NR GR     + V +           S  VE  GG     C+++G P P I W  +G  
Sbjct: 3009 ENRVGR-TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 3067

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
            L   +H    L +G L I    + D G Y+C+A N        +  +   V  L L   P
Sbjct: 3068 LR-GSHLRHQLQNGSLTIHRTERDDAGRYQCLAEN--------EMGVAKKVVILVLQSAP 3118

Query: 215  EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
                 PQ++T+       L C AT  P P + W +  G+ +     + L  L  G+L + 
Sbjct: 3119 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRAS--RRLRTLPDGSLWLE 3175

Query: 275  DVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQG 311
            +V    +G Y C A N  G+    TA+  L+V+GEPQG
Sbjct: 3176 NVETGDAGTYDCVAHNLLGS---ATARAFLVVRGEPQG 3210



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 109/452 (24%), Positives = 162/452 (35%), Gaps = 99/452 (21%)

Query: 18  ELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDG-SLHLA 76
           +L   + LG    +   PL LPCQ  G P  +I W ++       +GV +   G +LH+ 
Sbjct: 498 QLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHID 557

Query: 77  ALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLA------------SLSRFH---QHP 121
            +    S       + C A N  G   +  A V+++             + ++H   +H 
Sbjct: 558 HVELDHS-----GLFACQATNEAG---TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 609

Query: 122 ESI------EVERG-GVACFQCLIQGVPEPSISW-EHNGTALNTANHRVTLLPSGILHIT 173
            S        V RG G      L++G   P   W E  G  +       +L P   L I 
Sbjct: 610 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIE 662

Query: 174 SVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVL 233
            V   D G Y C A N+A     + A        L++L  P I  GP N  +  + +  L
Sbjct: 663 KVDLRDEGIYTCAATNLAGESKREVA--------LKVLVPPNIEPGPVNKAVLENASVTL 714

Query: 234 ECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGT 293
           EC+A+  P P VSW +  G       + V   +D   L I    +  +G Y C A+    
Sbjct: 715 ECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA- 771

Query: 294 HVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPA 353
                                                  GS      L +  P  + LP 
Sbjct: 772 ---------------------------------------GSTELRYGLRVNVPPRITLPP 792

Query: 354 QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN--NIRLTHNNSTL 411
            LP     P  ++ P       TC A G P   L+WLK+G  +SP     +++      L
Sbjct: 793 SLP----GPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 844

Query: 412 MLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            LA     D   Y CVA ++ G ++    L V
Sbjct: 845 TLASARASDSGRYSCVAVSAVGEDRQDVVLQV 876



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 91/414 (21%), Positives = 142/414 (34%), Gaps = 68/414 (16%)

Query: 38  LPCQVEGEPPVSISWQRDRL-ALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQ 96
           L C   G P   + W +DR   L     + +  DG +    L    S       Y CVA 
Sbjct: 237 LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV----LRITGSHVGDEGRYQCVAF 292

Query: 97  NRYGRLV-SRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTAL 155
           +  G+     + RV              + V    +    C  +GVP P+I+W  +G  L
Sbjct: 293 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 352

Query: 156 NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPE 215
            T+   V       L +     +D G Y C A N       +  +L + V        P 
Sbjct: 353 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA-EKATRLDVYV--------PP 403

Query: 216 ILSG----PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
            + G    P  +     +   LEC+A  HP P +SW   +G  +       L+  D   L
Sbjct: 404 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH-EGLPVAESNESRLE-TDGSVL 461

Query: 272 MISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIW 331
            +       SG+Y C A+ P        + VL    E Q P         P  L    + 
Sbjct: 462 RLESPGEASSGLYSCVASSP------AGEAVLQYSVEVQVP---------PQLLVAEGLG 506

Query: 332 RGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK 391
           + +   G+            P +LP                    C A G P   + WL+
Sbjct: 507 QVTTIVGQ------------PLELP--------------------CQASGSPVPTIQWLQ 534

Query: 392 NGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTG 445
           NG+       +++    +TL +  V ++   ++ C A N  G+  A   + V G
Sbjct: 535 NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 588



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 107/436 (24%), Positives = 156/436 (35%), Gaps = 88/436 (20%)

Query: 22   VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSR 81
            V+   D V V    + LPC+  G P   +SW +D   L ++S   L    SL L A+ + 
Sbjct: 2219 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAG 2275

Query: 82   RSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFH----QHPESIEVERGGVACFQCL 137
             S       Y CVA +  G     R   QL  +   H      P  + +  G      C 
Sbjct: 2276 DS-----GTYSCVAVSEAG---EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 2327

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
             QG P+P+I+W  +G AL       T L +       +   D G Y C+A + A      
Sbjct: 2328 AQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKS 2380

Query: 198  DAQLTLSVGPLRLLQEPEILS--GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
                      +R+   P I+   GP+ +        VLEC   + P P ++W R DG  I
Sbjct: 2381 FR--------VRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DG--I 2429

Query: 256  GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
             ++        + G  L +  +S   SG Y C A        R A G   V         
Sbjct: 2430 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA--------RNAAGSTSV--------- 2472

Query: 315  VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
              RV  H                                 +P     P +++     +A+
Sbjct: 2473 AFRVEIH--------------------------------TVPTIRSGPPAVNVSVNQTAL 2500

Query: 375  FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
              C A GVP   + W K+   L P +         +L +  V  +D   Y C+A NS GS
Sbjct: 2501 LPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 2560

Query: 435  NQASARLVVTGGPEPP 450
            ++    L V    EPP
Sbjct: 2561 DRQGRDLRVL---EPP 2573



 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 87/349 (24%), Positives = 132/349 (37%), Gaps = 78/349 (22%)

Query: 123 SIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHR-VTLLPSGILHITSVSQTDMG 181
           ++ +E GG     C   G P+P ++W    ++        V +L  G L + SVS  D G
Sbjct: 16  TVGLEAGG-----CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSG 70

Query: 182 TYRCVAWN-VASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSH 240
            Y C A N V ST  S+ A+L + V P   ++E        N++    Q+  LEC A   
Sbjct: 71  DYECQATNEVGST--SRRAKLVVYVPP--SIRED---GRKANVSGMAGQSLTLECDANGF 123

Query: 241 PWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ 300
           P P + W + D + +GV                                     +     
Sbjct: 124 PVPEIVWLK-DAQLVGVP------------------------------------LGWAGY 146

Query: 301 GVLLVQGEPQGPNWV--GRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEF 358
           G  L  G+  G   +  G+ L  P    G    RG++AGG     +A +     A L  F
Sbjct: 147 GWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGG-----SAQTKAPWXAGLAGF 201

Query: 359 VQWPQ----SLSKPP---------------GSSAIFTCVAQGVPESRLVWLKNGKVLSPG 399
            Q+P     S   PP               G+     C   GVP  ++ W K+ + + PG
Sbjct: 202 EQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG 261

Query: 400 N-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
             ++++  +   L + G  V DE  YQCVA +  G      +L V   P
Sbjct: 262 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPP 310


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score =  140 bits (352), Expect = 5e-33
 Identities = 129/462 (27%), Positives = 195/462 (42%), Gaps = 63/462 (13%)

Query: 30   AVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
            AV E  ++LPC+  G P  +I+WQ++ L +A      ++P G L +A      + P  A 
Sbjct: 3959 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIA-----HASPEDAG 4013

Query: 90   EYHCVAQNRYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISW 148
             Y C+A+N  G  + + R  VQ+  +         +    G  A   C  +G PEP+I+W
Sbjct: 4014 NYLCIAKNSAGSAMGKTRLVVQVPPV--IENGLPDLSTTEGSHAFLPCKARGSPEPNITW 4071

Query: 149  EHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPL 208
            + +G  ++ A  + T+ PSG L + ++   D GTY C A N A  R  +   LT+ V P+
Sbjct: 4072 DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRRVHLTILVLPV 4130

Query: 209  RLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
                     + P + +L +     L C A   P P + W+ ++ R +  EG+   D    
Sbjct: 4131 -------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSEQD--GG 4179

Query: 269  GNLMISDVSVQHSGVYVC-AANRPG-------THVRR------------------TAQGV 302
              L  + VS + SG YVC A NR G        HV+                   + Q  
Sbjct: 4180 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLD 4239

Query: 303  LLVQGEP-QGPNWV-------GRVLEHPSSLTGAWIWRGSRAGGKR--------LGLTAP 346
             +V+G+P    +W+       G  L H        I R  R    R        +G+   
Sbjct: 4240 CVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKK 4299

Query: 347  SSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTH 406
              +L+    P F   PQ ++   G      C A G P   + WL+ G+ L     +R T 
Sbjct: 4300 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR-TL 4358

Query: 407  NNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
             + +L L  V   D   Y CVA N  GS  A A LVV G P+
Sbjct: 4359 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 4400



 Score =  139 bits (350), Expect = 8e-33
 Identities = 149/545 (27%), Positives = 216/545 (39%), Gaps = 72/545 (13%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGS-LHLAALPSRRSLPSRAHEYHCV 94
            LVL C VE EP   I+W RD + L  ++       G  L L AL +  S      +Y C 
Sbjct: 3599 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-----GDYSCT 3653

Query: 95   AQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTA 154
            A+N  G   S   RV++ ++      P ++ V     A   C   GVP P +SW  +   
Sbjct: 3654 ARNAAGS-TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 3712

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA-STRHSQDAQLTLSVGPLRLLQE 213
            L+  + R  +LP G L I  V   D G Y C+A N A S R  +D         LR+L+ 
Sbjct: 3713 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD---------LRVLEP 3763

Query: 214  PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ-VLDILDTGNLM 272
            P I   P NLTLT H  A+L C A+  P PLV W + DG+ +     Q    +L +  L+
Sbjct: 3764 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALL 3822

Query: 273  ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ---GEPQGPNWVGRVLE-----HPSS 324
            ++    Q S  + C  +       R  Q  + V     + Q    V  +       H + 
Sbjct: 3823 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 3882

Query: 325  L---TGAWIWRGSRAGGKRLGL-TAPSSMLLPAQL------------------------- 355
            +   T +W   G++ G +  G   +PS  L   Q                          
Sbjct: 3883 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 3942

Query: 356  -----PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNST 410
                 P     P  +        +  C A G+P   + W K G  ++ G + ++      
Sbjct: 3943 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ- 4001

Query: 411  LMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP--EPPRPQGPACHGSLYFCHSSV 468
            L +A  S ED   Y C+A+NS GS     RLVV   P  E   P      GS  F     
Sbjct: 4002 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 4061

Query: 469  LGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSA 528
             G+  P+    I +    +PV   SG E +  I + + E +  NLE   A T    A +A
Sbjct: 4062 RGSPEPN----ITWDKDGQPV---SGAEGKFTI-QPSGELLVKNLEGQDAGTYTCTAENA 4113

Query: 529  EGASQ 533
             G ++
Sbjct: 4114 VGRAR 4118



 Score =  109 bits (273), Expect = 7e-24
 Identities = 119/460 (25%), Positives = 174/460 (37%), Gaps = 81/460 (17%)

Query: 40   CQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRY 99
            C   G P   ISW R+  AL  +S + +   G+L +  +      P  A  Y C A N  
Sbjct: 629  CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVA-----PEDAGNYSCQATNEV 683

Query: 100  GRLVSRRARVQLASLSRFHQHPESIE-------VERGGVACFQCLIQGVPEPSISWEHNG 152
            G            +++ ++  P S+        V  G  A   C   GVP P + W   G
Sbjct: 684  G--------TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 735

Query: 153  TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
              +  A    +   SG L I +  + D GTY C A N         A++ L+VG      
Sbjct: 736  LEMILAPEGSS---SGKLRIPAAQERDAGTYTCRAVNELG---DASAEIQLAVG-----H 784

Query: 213  EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV-----EGIQVLDILD 267
             P++   P+++T+ + ++A+L C AT  P P V+W R DG+ +G+      G +     D
Sbjct: 785  APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ-PD 843

Query: 268  TGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG--RVLE-HPSS 324
            +G L    V+ +    YVC A      V+  A+ ++     PQ  +     RVLE  P S
Sbjct: 844  SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 903

Query: 325  L-----------TGAWIWRG-SRAGGKRLGLTAPSSMLLPAQLPE--------------- 357
            L              W+  G     G R  + A  S+ L   L E               
Sbjct: 904  LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 963

Query: 358  -------FVQWPQSLSKP-------PGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIR 403
                    VQ P  +           G  A   CVA GVP   + W K    L+      
Sbjct: 964  QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 1023

Query: 404  LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
                  TL++A  S +D   Y C A N+ G +    RL V
Sbjct: 1024 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSV 1063



 Score =  108 bits (270), Expect = 2e-23
 Identities = 139/603 (23%), Positives = 215/603 (35%), Gaps = 99/603 (16%)

Query: 24   ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
            E G+   + +H + L C+  G P  +I+W +D   L   + V     G      L   R+
Sbjct: 1508 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR----QLQLGRA 1563

Query: 84   LPSRAHEYHCVAQNRYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACFQCLIQG 140
              S A  Y C A N  G    +  R+ +    ++      P  ++   G     +C+ +G
Sbjct: 1564 QSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622

Query: 141  VPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQ 200
             P P++SW H G  +  +N         +L + S  +   G Y CVA + A     Q   
Sbjct: 1623 HPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YS 1681

Query: 201  LTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
            + + V P  L+ E     G   +T  V Q   L C A+  P P + W +    +  + G+
Sbjct: 1682 VEVQVPPQLLVAE-----GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 1736

Query: 261  QVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
            QV     T  L I  V + HSG++ C A N  GT     A+  + V GE     W   VL
Sbjct: 1737 QVASQGTT--LHIDHVELDHSGLFACQATNEAGT---AGAEVEVSVHGE-----WAPGVL 1786

Query: 320  -----------EHPSSLTGA--------------------WIWRGSRAGGKRLGLTAPSS 348
                       EH SS   A                    W   GS   G+  G+    S
Sbjct: 1787 EVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 1845

Query: 349  MLLPAQL---------------------------------PEFVQWPQSLSKPPGSSAIF 375
            +  P Q+                                 P     P + +    +S   
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTL 1905

Query: 376  TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
             C+A GVP   + W K  + +S    + ++ +   L +    + D   Y+CVA N  GS 
Sbjct: 1906 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965

Query: 436  QASARLVVTGGPE---PPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEP 492
            +    L V   P    PP   GP    +      +  GA  P+    + ++    PV   
Sbjct: 1966 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT----LMWLKDGNPVSPA 2021

Query: 493  SGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTMGSNLGEALN 552
              P LQ  +  G      ++   + +      A SA G  +    +      S LGE LN
Sbjct: 2022 GTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN 2079

Query: 553  LPV 555
            + V
Sbjct: 2080 VSV 2082



 Score =  107 bits (267), Expect = 3e-23
 Identities = 113/408 (27%), Positives = 165/408 (40%), Gaps = 85/408 (20%)

Query: 35   PLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
            P+ L C  +G P  +I+W +D  AL      T + + S     L  R      A  Y C+
Sbjct: 3512 PMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRVLRVRD-----AGLYTCL 3560

Query: 95   AQNRYGRLV-SRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGT 153
            A++  G +  S R RVQ        + P  +     G    +C ++  P P I+W  +G 
Sbjct: 3561 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGI 3620

Query: 154  ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQE 213
             L    H         L + ++S  D G Y C A N A +        T     + +   
Sbjct: 3621 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS--------TSVAFRVEIHTV 3672

Query: 214  PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSR----LDGRSIGVEGIQVLDILDTG 269
            P I SGP  + ++V+QTA+L C A   P PLVSW +    LD RS   E      IL  G
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE------ILPEG 3726

Query: 270  NLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
            +L I  V  Q +G Y+C A+N  G+              + QG +   RVLE P+     
Sbjct: 3727 SLRIQPVLAQDAGHYLCLASNSAGS--------------DRQGRDL--RVLEPPAI---- 3766

Query: 329  WIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLV 388
                            +PS++ L A  P                A+  C A G P+  +V
Sbjct: 3767 --------------APSPSNLTLTAHTP----------------ALLPCEASGSPKPLVV 3796

Query: 389  WLKNGKVLS---PGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
            W K+G+ L         RL  +N+ L+L     +D A ++CV  N  G
Sbjct: 3797 WWKDGQKLDFRLQQGAYRLLPSNA-LLLTAPGPQDSAQFECVVSNEVG 3843



 Score =  102 bits (254), Expect = 1e-21
 Identities = 113/458 (24%), Positives = 163/458 (35%), Gaps = 64/458 (13%)

Query: 35   PLVLPCQVEGEPPVSISWQRDRLAL---ANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
            P +LPC+  G P   + W +D   L     +    L+P  +L L A P     P  + ++
Sbjct: 3780 PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTA-PG----PQDSAQF 3834

Query: 92   HCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHN 151
             CV  N  G    R  +V +              V         C   G+P P++SW   
Sbjct: 3835 ECVVSNEVGE-AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 3893

Query: 152  GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
            G  L        + PSG L I        G Y C A N A   H +   LT+   P+   
Sbjct: 3894 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASPV--- 3949

Query: 212  QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
                +   P  +     +  +L C A+  P P ++W + +G ++   G+    +L  G L
Sbjct: 3950 ----VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK-EGLNVAT-GVST-QVLPGGQL 4002

Query: 272  MISDVSVQHSGVYVC-AANRPGTHVRRTAQGV----LLVQGEPQGPNWVGRVLEHPSSLT 326
             I+  S + +G Y+C A N  G+ + +T   V    ++  G P      G     P    
Sbjct: 4003 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 4062

Query: 327  GA------WIWRGSRAGGKRLGLT-APSSMLLPAQ------------------------- 354
            G+      W   G    G     T  PS  LL                            
Sbjct: 4063 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 4122

Query: 355  -----LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNS 409
                 LP F   P   S   G      C A+G P  R+ W  N + ++ G  +      S
Sbjct: 4123 LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQDGGS 4180

Query: 410  TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
            TL  A VS ED   Y C AEN  G  QA + + V   P
Sbjct: 4181 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 4218



 Score =  101 bits (251), Expect = 2e-21
 Identities = 124/468 (26%), Positives = 170/468 (36%), Gaps = 117/468 (25%)

Query: 28   TVAVWE-HPLVLPCQV-EGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP 85
            TV V E  P+ LPC V  G P     W +D   L   S  ++  DGSLHL      R+L 
Sbjct: 893  TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-----RALQ 947

Query: 86   SRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIE--VERGGVACFQCLIQGVPE 143
              A  Y CVA N  G   S+   V+L        HP +       G  A   C+  GVP 
Sbjct: 948  EHAGRYSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 1004

Query: 144  PSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLT- 202
            P+I+W     AL +      +   G L I   S  D G Y C A N      SQ+ +L+ 
Sbjct: 1005 PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF-SSQEMRLSV 1063

Query: 203  ---------------LSVGPLRLLQ------------------------------EPEIL 217
                           L  G LRL Q                               P++ 
Sbjct: 1064 NRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQ 1123

Query: 218  SGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVS 277
             GP+ L + V +   L C+A  +P P +SWS+ DG  +   G Q       G++  + + 
Sbjct: 1124 PGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK-DGVVLQGRGPQ-------GSVHFAAIR 1175

Query: 278  VQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAG 337
               +G Y C A+         + GV   + E        RVLE P        W      
Sbjct: 1176 TSDAGRYRCEAS--------NSAGVDAWEVEL-------RVLEPPH-------WGADETS 1213

Query: 338  GKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK--NGKV 395
            G                          L +  G +A   C A+G P+ ++ W K  + + 
Sbjct: 1214 G-------------------------LLERVAGENASLPCPARGTPKPQVTWRKGPSSEP 1248

Query: 396  LSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            L     + +    S L LA VS  D   Y+C A N  GS    A+LVV
Sbjct: 1249 LHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295



 Score =  100 bits (248), Expect = 6e-21
 Identities = 117/443 (26%), Positives = 180/443 (40%), Gaps = 70/443 (15%)

Query: 37   VLPCQVEGEPPVSISWQRD-------RLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
            +L C+  G PP +++W+R        RL     S       G L   ++      P    
Sbjct: 804  LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP---- 859

Query: 90   EYHCVAQNRYGR-------LVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLI-QGV 141
             Y C A+N +G+       +V+  A  Q+AS +       ++ V  G      C++  G 
Sbjct: 860  -YVCEARNVFGKVQAEARLIVTGHAPPQIASSA------PTVRVLEGQPVSLPCIVLAGR 912

Query: 142  PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
            P P   W  +G  L   + R ++   G LH+    Q   G Y CVA N A ++H +D +L
Sbjct: 913  PLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH-RDVEL 970

Query: 202  TLSVGPLRLLQEPEILSGPQNLTLTVHQT-----AVLECIATSHPWPLVSWSRLDGRSIG 256
             + V P R+           + T T H T     A L C+A+  P P ++W++ +  ++ 
Sbjct: 971  VVQVPP-RI-----------HPTATHHITNEGVPASLPCVASGVPAPTITWTK-ETNALT 1017

Query: 257  VEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPG-------THVRRTAQGVLLVQGE 308
              G    ++   G L+I+  S Q +G YVC A N  G         V R A    + +  
Sbjct: 1018 SRGPH-YNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEY 1076

Query: 309  PQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ-WPQSLSK 367
               P+   R+ +     +G +    S   G     +A    +L  Q+P  VQ  P+ L  
Sbjct: 1077 GLLPSGSLRLAQVQVGDSGHYECTASNPAG-----SASHRYVLGVQVPPQVQPGPRVLKV 1131

Query: 368  PPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCV 427
              G +    CVA+G PE +L W K+G VL         H       A +   D   Y+C 
Sbjct: 1132 LVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVH------FAAIRTSDAGRYRCE 1185

Query: 428  AENSTGSNQASARLVVTGGPEPP 450
            A NS G +     L V    EPP
Sbjct: 1186 ASNSAGVDAWEVELRVL---EPP 1205



 Score =  100 bits (248), Expect = 6e-21
 Identities = 108/416 (25%), Positives = 161/416 (38%), Gaps = 66/416 (15%)

Query: 23   QELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRR 82
            +EL  +V   E  + L CQ    PP  +SW +D   L    GV L  D +L    L   R
Sbjct: 2076 EELNVSVVANES-VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL----LQVDR 2130

Query: 83   SLPSRAHEYHCVAQNRYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
            +    A  Y C A N+ G         V +A +    +   ++ V  G      C  +GV
Sbjct: 2131 ADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRES-HTLTVREGHPTSLSCECRGV 2189

Query: 142  PEPSISWEHNGTAL--NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
            P P ISW  +G  L    A  +       +L++        GTY C   NV     SQD 
Sbjct: 2190 PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG-NSSQDL 2248

Query: 200  QLTLSVGP-LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
            QL + V P +   +EP     P  +++     A LEC AT  P P V+W R DG+ +G E
Sbjct: 2249 QLEVHVPPQIAGPREP-----PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAE 2302

Query: 259  -GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGR 317
             G+Q+ +     +L +      H+G Y C A        R  +  +LV  E  G      
Sbjct: 2303 LGLQLQN--QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD----- 2355

Query: 318  VLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTC 377
             L+  +++T A              L +P ++L                          C
Sbjct: 2356 -LDPLTNITAA--------------LHSPLTLL--------------------------C 2374

Query: 378  VAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
             A G+P   + W +  + +SPG +  L      L +     +D  +Y C+A N  G
Sbjct: 2375 EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 2430



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 138/552 (25%), Positives = 200/552 (36%), Gaps = 95/552 (17%)

Query: 24   ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
            +L    A+    + LPC V   P   ++W +D  AL+    V L+P        L   R+
Sbjct: 2943 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH----TLQLGRA 2998

Query: 84   LPSRAHEYHCVAQNRYGRLVSRRARVQLASL--SRFHQHP----ESIEVERGGVACFQCL 137
              S +  Y C A N  GR    +  VQL+ L    F Q P    +++ V  G  A   C 
Sbjct: 2999 RLSDSGMYTCEALNAAGR---DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 3055

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
               +PEP+++W  +G  L  A     L     L I     +D G Y C   NVA      
Sbjct: 3056 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG----- 3110

Query: 198  DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA----VLECIATSHPWPLVSW--SRLD 251
            +A  T ++     +Q P     P+  T TV Q A    VL C  +  P P V+W   R+ 
Sbjct: 3111 EAVRTFTL----TVQVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 3164

Query: 252  GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
              S  V G+    +   G L +S +    +G Y C A       R+     +LV    + 
Sbjct: 3165 VESSAVHGV----VSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS 3220

Query: 312  PNWV-------GRVLEHPSSLTG------AWIWRGSRAG---GKRL------------GL 343
                       G+ +       G      AW+  GS  G   G  L            GL
Sbjct: 3221 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGL 3280

Query: 344  TAPS---------------------SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
             A                       ++L+P  + +      +L   PG      C  +G 
Sbjct: 3281 RASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 3340

Query: 383  PESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
            P   + WLK+G  L       L  +  TL ++ V + D  I+ CVA +  G    +  L 
Sbjct: 3341 PPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 3400

Query: 443  VTGGP--EPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPS---GP 495
            V   P  EP   Q       GSL        G   P    ++ ++    P+   S   GP
Sbjct: 3401 VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP----LVSWMKDGEPLLSQSLEQGP 3456

Query: 496  ELQ-EAISKGTS 506
             LQ EA+  G S
Sbjct: 3457 SLQLEAVGAGDS 3468



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 112/426 (26%), Positives = 167/426 (39%), Gaps = 82/426 (19%)

Query: 38   LPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAHEYHCV 94
            L C+ +G+PP  ++W +D   L  + G  L   +  GSL L  L +     S A  Y CV
Sbjct: 3237 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA-----SDAGAYTCV 3291

Query: 95   AQNRYGRLVSRRARVQLASLSRFHQHPE---SIEVERGGVACFQCLIQGVPEPSISWEHN 151
            A N  G   +R   V +       Q  +   ++    G +    C ++G P   +SW  +
Sbjct: 3292 AHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 3350

Query: 152  GTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
            G  L   + R  L  SG  L I+ V   D G + CVA   AS     D   TL V    +
Sbjct: 3351 GLPL-PLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGVADRNFTLQVQVPPV 3406

Query: 211  LQEPEILSGPQNLTLTVHQTAV-LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
            L+  E     QN  + V  + V L C A   P PLVSW + DG  +  + ++        
Sbjct: 3407 LEPVEF----QNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLE-----QGP 3456

Query: 270  NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
            +L +  V    SG Y C A       RR  Q                             
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------------------------- 3487

Query: 330  IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
                              +++ P  + +  Q P  LS  PG+     C AQG P+  + W
Sbjct: 3488 -----------------LTVMEPPHIEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITW 3529

Query: 390  LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
             K+G+ L+     RL +N+    +  + V D  +Y C+AE+  G+ + S R+ V   P  
Sbjct: 3530 HKDGQALT-----RLENNSRATRV--LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI 3582

Query: 450  PRPQGP 455
              P+GP
Sbjct: 3583 VGPRGP 3588



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 131/596 (21%), Positives = 217/596 (36%), Gaps = 88/596 (14%)

Query: 31   VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
            V  +P  L C     PP  ++W R+   L+    V+++  G   +  +P  R+    A  
Sbjct: 2763 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRA--ENAGR 2818

Query: 91   YHCVAQNRYGRLVSRRARVQLAS---LSRFHQHPESIEVERGGVACFQCLIQGVPEPSIS 147
            Y C A N  G        + L     L    +  E + V        QC   G P P+IS
Sbjct: 2819 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 2878

Query: 148  WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
            W  NG   + +     L    +L +++    D  +Y CVA N A    S +   TL V  
Sbjct: 2879 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG---SAEKLFTLRV-- 2933

Query: 208  LRLLQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDI 265
                Q P  ++G   + +T  ++ +  L C   +HP P V+W + D +++ + G +V  +
Sbjct: 2934 ----QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK-DSQALSL-GEEVFLL 2987

Query: 266  LDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLV----QGEPQGPNWVGRVLEH 321
              T  L +    +  SG+Y C A       ++  Q  +LV    +  P+GP     V   
Sbjct: 2988 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 3047

Query: 322  PSSL-----------TGAWIWRG----------SRAGGKRLGL----------------- 343
              ++           T  W   G          +  GG+RL +                 
Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 3107

Query: 344  ---TAPSSMLLPAQLPEFVQWP--QSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
                A  +  L  Q+P   + P  +++S+  GS  + TC   GVP   + WLK+   +  
Sbjct: 3108 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 3167

Query: 399  GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPA-- 456
                 +      L L+ +       Y CVAEN+    +    + V   P   R  G A  
Sbjct: 3168 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-IRSSGVARE 3226

Query: 457  ---CHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNL 513
                 G          G  PP     + ++    P+G+  GP L+  +  G+        
Sbjct: 3227 HHVLEGQEVRLDCEADGQPPPD----VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 3282

Query: 514  EPATAYTIHLRAYSAEGASQDSAPIF-----------ASTMGSNLGEALNLPVPLK 558
              A AYT      + E A   +  +            + T+ S  GE + +  P++
Sbjct: 3283 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVR 3338



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 119/495 (24%), Positives = 187/495 (37%), Gaps = 102/495 (20%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            + L C   G PP  +SW +    +++  GVT+  DG +    L   ++  S A  Y CVA
Sbjct: 1903 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVA 1958

Query: 96   QN-------RYGRLVSRRARVQLASLSRFHQHPESIE--VERGGVACFQCLIQGVPEPSI 146
             N       RYG  V+   R+ L         P S+   V         C   G P P++
Sbjct: 1959 SNVAGSTELRYGLRVNVPPRITL---------PPSLPGPVLVNTPVRLTCNATGAPSPTL 2009

Query: 147  SWEHNGTALNTANHR-VTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
             W  +G  ++ A    + + P G +L + S   +D G Y CVA +       +D Q  + 
Sbjct: 2010 MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVV- 2064

Query: 205  VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE-GIQVL 263
               L++   P IL    N+++  +++  LEC + + P P++SW + DGR +    G+ + 
Sbjct: 2065 ---LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLEPRPGVHL- 2119

Query: 264  DILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHP 322
               D   L +    V  +G Y C A N+ G   +     V           WV  V    
Sbjct: 2120 -SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV-----------WVAPVFPLR 2167

Query: 323  SSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
             S T                                      L+   G     +C  +GV
Sbjct: 2168 ESHT--------------------------------------LTVREGHPTSLSCECRGV 2189

Query: 383  PESRLVWLKNGKVLSPGNNIRLTHNNST---LMLAGVSVEDEAIYQCVAENSTGSNQASA 439
            P  ++ W K+G+ L PG    L H ++    L L    +  E  Y C   N  G++    
Sbjct: 2190 PFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL 2248

Query: 440  RLVV-----TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSG 494
            +L V       GP  P  Q       +     +  G  PP+    + +    +PVG   G
Sbjct: 2249 QLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT----VTWERDGQPVGAELG 2304

Query: 495  PELQEAISKGTSEHV 509
             +LQ   ++G S HV
Sbjct: 2305 LQLQ---NQGQSLHV 2316



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 110/465 (23%), Positives = 172/465 (36%), Gaps = 72/465 (15%)

Query: 35  PLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
           PL++ C V    P  +  +R    L  E       + S  +      R+  +    Y C 
Sbjct: 443 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEIL-----RASKAEEGTYECT 497

Query: 95  AQNRYGRLVSRRARVQLASLSRFHQ--HPESIEVERGGVACFQCLIQGVPEPSISWEHNG 152
           A +R G   + RA+ Q+       Q     ++ V  G  A   C + G    +++W  + 
Sbjct: 498 AVSRAG---TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW 554

Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
             L  +  RV  L    L I+ +  TD G Y+CVA N           +T +   L + +
Sbjct: 555 RVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG--------VTRASVWLLVRE 606

Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM 272
            P++     +   +      + C A+ +P P +SWSR    S  ++    + +   G L+
Sbjct: 607 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR---ESQALQEDSRIHVDAQGTLI 663

Query: 273 ISDVSVQHSGVYVC-AANRPGTH----------------------VRRTAQGVLLVQGEP 309
           I  V+ + +G Y C A N  GT                       V    + VL+ +   
Sbjct: 664 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASG 723

Query: 310 QGPNWVGRVLEHPSSLTGAWIWRGSRAGGKR-------------------LGLTAPSSML 350
             P    RV+ +   L       GS +G  R                   LG  +    L
Sbjct: 724 VPP---PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 780

Query: 351 LPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKN-----GKVLSPGNNIRLT 405
                P+  + P+ ++   G SA+  C A G P   + W +      G  L  G   R  
Sbjct: 781 AVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR 840

Query: 406 HNNS-TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
             +S  L    V+ ED+A Y C A N  G  QA ARL+VTG   P
Sbjct: 841 QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 885



 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 116/433 (26%), Positives = 169/433 (39%), Gaps = 89/433 (20%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            L L C  EG P   +SW +D + L         P GS+H AA+ +     S A  Y C A
Sbjct: 1137 LDLNCVAEGNPEPQLSWSKDGVVLQGRG-----PQGSVHFAAIRT-----SDAGRYRCEA 1186

Query: 96   QNRYGRLVSRRARVQLASLSRFHQHPES----IEVERGGVACFQCLIQGVPEPSISWEHN 151
             N  G        V+L  L   H   +     +E   G  A   C  +G P+P ++W   
Sbjct: 1187 SNSAG---VDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKG 1243

Query: 152  GTALNTANHR-VTLLPSGILHITSVSQTDMGTYRCVAWN-VASTRHSQDAQLTLSVGPLR 209
             ++        V +L  G L + SVS  D G Y C A N V ST  S+ A+L + V P  
Sbjct: 1244 PSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST--SRRAKLVVYVPPS- 1300

Query: 210  LLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSW---SRLDGRSIGVEG------- 259
             ++E        N++    Q+  LEC A   P P + W   ++L G  +G  G       
Sbjct: 1301 -IRED---GRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 1356

Query: 260  --IQVLDILDTG-NLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGPNWV 315
              +    +LD G +L    +    SG+Y C A N+ GT  R                ++ 
Sbjct: 1357 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR----------------DFH 1400

Query: 316  GRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIF 375
              VL  PS L       G+ A  + LGL                          G+    
Sbjct: 1401 LLVLTPPSVL-------GAGAAQEVLGLA-------------------------GADVEL 1428

Query: 376  TCVAQGVPESRLVWLKNGKVLSPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
             C   GVP  ++ W K+ + + PG  ++++  +   L + G  V DE  YQCVA +  G 
Sbjct: 1429 QCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 1488

Query: 435  NQASARLVVTGGP 447
                 +L V   P
Sbjct: 1489 QARDFQLRVHAPP 1501



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 95/421 (22%), Positives = 156/421 (37%), Gaps = 68/421 (16%)

Query: 34   HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP----SRAH 89
            HP  L C+  G P   ISW++D   L  E        G  H++A+     L     ++  
Sbjct: 2178 HPTSLSCECRGVPFPKISWRKDGQPLPGEGA------GLQHVSAVGRLLYLGQAQLAQEG 2231

Query: 90   EYHCVAQNRYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSI 146
             Y C   N  G   S+  ++++     ++   + P  + V + GVA  +C   G P P++
Sbjct: 2232 TYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTV 2290

Query: 147  SWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVG 206
            +WE +G  +              LH+        G Y CVA N+A  R  +  +L++ V 
Sbjct: 2291 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELSVLVP 2349

Query: 207  PLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDIL 266
            P  L+ + + L+   N+T  +H    L C A   P P + W R  G      G     + 
Sbjct: 2350 P-ELIGDLDPLT---NITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLA 2403

Query: 267  DTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
                L ++    Q SG+Y C A+      RR               N+   VL  PS   
Sbjct: 2404 GGWMLKMTQTQEQDSGLYSCLASNEAGEARR---------------NFSVEVLVPPSI-- 2446

Query: 327  GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
                                          E     + +    G +A   C   G P+ +
Sbjct: 2447 ------------------------------ENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 2476

Query: 387  LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
            L W K+G+ L+ G+   ++ +   L +   ++     Y C+A N+ G      +L V   
Sbjct: 2477 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 2536

Query: 447  P 447
            P
Sbjct: 2537 P 2537



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 101/415 (24%), Positives = 163/415 (39%), Gaps = 83/415 (20%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            + + C V G PP+ +SW +D L L       L   GS H   + S+  L + A  + CVA
Sbjct: 3331 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL--HGSGHTLRI-SKVQL-ADAGIFTCVA 3386

Query: 96   QNRYGRLVSRR---ARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNG 152
             +  G  V+ R    +VQ+  +    +    + V RG +    C  +GVP P +SW  +G
Sbjct: 3387 ASPAG--VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDG 3444

Query: 153  TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA--STRHSQDAQLTLSVGPLRL 210
              L +     +L     L + +V   D GTY CVA + A  + RH Q          L +
Sbjct: 3445 EPLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------LTV 3490

Query: 211  LQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
            ++ P I     P  L+LT      L C A   P P ++W + DG        Q L  L+ 
Sbjct: 3491 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG--------QALTRLEN 3541

Query: 269  GNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
             +     + V+ +G+Y C A  P   + ++                              
Sbjct: 3542 NSRATRVLRVRDAGLYTCLAESPAGAIEKSF----------------------------- 3572

Query: 329  WIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLV 388
                       R+ + AP +++ P + P FV     +   PG   +  C  +  P  ++ 
Sbjct: 3573 -----------RVRVQAPPNIVGP-RGPRFV-----VGLAPG-QLVLECSVEAEPAPKIT 3614

Query: 389  WLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            W ++G VL    + +       L L  +S  D   Y C A N+ GS   + R+ +
Sbjct: 3615 WHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 3669



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 111/460 (24%), Positives = 174/460 (37%), Gaps = 81/460 (17%)

Query: 16   GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHL 75
            G+E +  +E+  TV    +P+ L C+    P  +I+W +D         + L+P G+  L
Sbjct: 2542 GAEDSADEEVTVTV---NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP-GTHGL 2597

Query: 76   AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHP------ESIEVERG 129
              L +++     A +Y CV  N  G  V       L   S     P      + ++ +  
Sbjct: 2598 QILNAQKE---DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN 2654

Query: 130  GVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
                 +C    VP P+I W  +G  +  ++    L    +L I     +D G Y CVA N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714

Query: 190  VASTRHSQDAQLTLSVGPL------------RLLQEPEILSG-PQNLTLTVHQTAVLECI 236
            VA     QD  + + V P+             L +E E   G  +   +  +  A L C 
Sbjct: 2715 VAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 2773

Query: 237  ATSHPWPLVSWSRLD-GRSIGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTH 294
              + P P ++W R D   S G E    + +L  G  L I  V  +++G Y C A+     
Sbjct: 2774 TNAIPPPDLTWYREDQPLSAGDE----VSVLQGGRVLQIPLVRAENAGRYSCKAS----- 2824

Query: 295  VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
                            G +W+   L                     L LT P   ++   
Sbjct: 2825 -------------NEVGEDWLHYEL---------------------LVLTPP---VILGD 2847

Query: 355  LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
              E V   + ++    S+    C A G P   + WL+NG   SP   +++  +   L ++
Sbjct: 2848 TEELV---EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 2904

Query: 415  GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQG 454
               V D A Y CVAEN  GS   + +L       PPR  G
Sbjct: 2905 TAEVADAASYMCVAENQAGS---AEKLFTLRVQVPPRIAG 2941



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 109/430 (25%), Positives = 154/430 (35%), Gaps = 89/430 (20%)

Query: 38   LPCQVEGEPPVSISWQRDRLA--LANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            LPC   G P   ++W++   +  L  + GV ++ +GSL LA++      P+ + +Y C A
Sbjct: 1226 LPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVS-----PADSGDYECQA 1280

Query: 96   QNRYGRLVSRRAR--VQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHN-- 151
             N  G   SRRA+  V +    R      ++    G     +C   G P P I W  +  
Sbjct: 1281 TNEVGS-TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQ 1339

Query: 152  --GTALNTAN------------HRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHS 196
              G  L  A             HR  LL  G  LH   + + D G Y C A N A T   
Sbjct: 1340 LVGVPLGWAGYGWDLGWGQVGGHR--LLDEGQSLHFPRIQEGDSGLYSCRAENQAGT--- 1394

Query: 197  QDAQLTLSVGPLRLLQEPEIL--SGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRS 254
              AQ       L +L  P +L     Q +         L+C  +  P P V W++   R 
Sbjct: 1395 --AQRDFH---LLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTK--DRQ 1447

Query: 255  IGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPN 313
              + G   L + + G  L I+   V   G Y C A  P     R  Q  L V   P    
Sbjct: 1448 PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQ--LRVHAPPT--- 1502

Query: 314  WVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSA 373
                            IW GS   G+   +      LL                      
Sbjct: 1503 ----------------IW-GSNETGEVAVMEDHLVQLL---------------------- 1523

Query: 374  IFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
               C A+GVP   + W K+G +L     +  T     L L      D  +Y C A N+ G
Sbjct: 1524 ---CEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVG 1580

Query: 434  SNQASARLVV 443
            + + + RL V
Sbjct: 1581 AAEKATRLDV 1590



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 99/437 (22%), Positives = 161/437 (36%), Gaps = 78/437 (17%)

Query: 25   LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
            L +  A    PL L C+  G PP +I W R    ++      L+  G +    L   ++ 
Sbjct: 2359 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM----LKMTQTQ 2414

Query: 85   PSRAHEYHCVAQNRYGRLVSRR---ARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
               +  Y C+A N  G   +RR     V +          E I+V  G  A   C + G 
Sbjct: 2415 EQDSGLYSCLASNEAGE--ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGH 2472

Query: 142  PEPSISWEHNGTAL--NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVA--STRHS 196
            P+P ++W  +G  L    A+H   + P G+ L +   + +  G Y C+A N     T+H 
Sbjct: 2473 PQPKLTWFKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHF 2529

Query: 197  QDAQLTLSVGPLRLLQEPEILSGPQN-----LTLTVHQTAVLECIATSHPWPLVSWSRLD 251
            Q          L +L  P IL G ++     +T+TV+    L C A + P P ++W +  
Sbjct: 2530 Q----------LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG 2579

Query: 252  GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQ 310
                    IQ+L    T  L I +   + +G Y C   N  G  V+     VL+      
Sbjct: 2580 APFEASRNIQLLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI------ 2631

Query: 311  GPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPG 370
                                               P S+     L E     + +     
Sbjct: 2632 -----------------------------------PPSISKDDPLGEV--GVKEVKTKVN 2654

Query: 371  SSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAEN 430
            S+    C +  VP   + W K+G+ ++P + +++      L +    V D   Y CVA N
Sbjct: 2655 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 2714

Query: 431  STGSNQASARLVVTGGP 447
              G +     +++   P
Sbjct: 2715 VAGEDDQDFNVLIQVPP 2731



 Score = 80.1 bits (196), Expect = 6e-15
 Identities = 81/278 (29%), Positives = 115/278 (41%), Gaps = 24/278 (8%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            L L C   G P   I W  +   +    GV+    GS    A  SR      +  Y C A
Sbjct: 4146 LWLRCAARGSPTPRIGWTVNDRPVTE--GVSEQDGGSTLQRAAVSRED----SGTYVCWA 4199

Query: 96   QNRYGRLVSRRARVQLASLSRFHQHPESIEVER-GGVACFQCLIQGVPEPSISWEHNGTA 154
            +NR GR     + V +           S  VE  GG     C+++G P P I W  +G  
Sbjct: 4200 ENRVGR-TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 4258

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
            L   +H    L +G L I    + D G Y+C+A N        +  +   V  L L   P
Sbjct: 4259 LR-GSHLRHQLQNGSLTIHRTERDDAGRYQCLAEN--------EMGVAKKVVILVLQSAP 4309

Query: 215  EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
                 PQ++T+       L C AT  P P + W +  G+ +     + L  L  G+L + 
Sbjct: 4310 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRAS--RRLRTLPDGSLWLE 4366

Query: 275  DVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQG 311
            +V    +G Y C A N  G+    TA+  L+V+GEPQG
Sbjct: 4367 NVETGDAGTYDCVAHNLLGS---ATARAFLVVRGEPQG 4401



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 109/452 (24%), Positives = 162/452 (35%), Gaps = 99/452 (21%)

Query: 18   ELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDG-SLHLA 76
            +L   + LG    +   PL LPCQ  G P  +I W ++       +GV +   G +LH+ 
Sbjct: 1689 QLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHID 1748

Query: 77   ALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLA------------SLSRFH---QHP 121
             +    S       + C A N  G   +  A V+++             + ++H   +H 
Sbjct: 1749 HVELDHS-----GLFACQATNEAG---TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 1800

Query: 122  ESI------EVERG-GVACFQCLIQGVPEPSISW-EHNGTALNTANHRVTLLPSGILHIT 173
             S        V RG G      L++G   P   W E  G  +       +L P   L I 
Sbjct: 1801 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIE 1853

Query: 174  SVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVL 233
             V   D G Y C A N+A     + A        L++L  P I  GP N  +  + +  L
Sbjct: 1854 KVDLRDEGIYTCAATNLAGESKREVA--------LKVLVPPNIEPGPVNKAVLENASVTL 1905

Query: 234  ECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGT 293
            EC+A+  P P VSW +  G       + V   +D   L I    +  +G Y C A+    
Sbjct: 1906 ECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA- 1962

Query: 294  HVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPA 353
                                                   GS      L +  P  + LP 
Sbjct: 1963 ---------------------------------------GSTELRYGLRVNVPPRITLPP 1983

Query: 354  QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN--NIRLTHNNSTL 411
             LP     P  ++ P       TC A G P   L+WLK+G  +SP     +++      L
Sbjct: 1984 SLP----GPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 2035

Query: 412  MLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
             LA     D   Y CVA ++ G ++    L V
Sbjct: 2036 TLASARASDSGRYSCVAVSAVGEDRQDVVLQV 2067



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 107/436 (24%), Positives = 156/436 (35%), Gaps = 88/436 (20%)

Query: 22   VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSR 81
            V+   D V V    + LPC+  G P   +SW +D   L ++S   L    SL L A+ + 
Sbjct: 3410 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAG 3466

Query: 82   RSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFH----QHPESIEVERGGVACFQCL 137
             S       Y CVA +  G     R   QL  +   H      P  + +  G      C 
Sbjct: 3467 DS-----GTYSCVAVSEAG---EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 3518

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
             QG P+P+I+W  +G AL       T L +       +   D G Y C+A + A      
Sbjct: 3519 AQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKS 3571

Query: 198  DAQLTLSVGPLRLLQEPEILS--GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
                      +R+   P I+   GP+ +        VLEC   + P P ++W R DG  I
Sbjct: 3572 FR--------VRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DG--I 3620

Query: 256  GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
             ++        + G  L +  +S   SG Y C A        R A G   V         
Sbjct: 3621 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA--------RNAAGSTSV--------- 3663

Query: 315  VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
              RV  H                                 +P     P +++     +A+
Sbjct: 3664 AFRVEIH--------------------------------TVPTIRSGPPAVNVSVNQTAL 3691

Query: 375  FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
              C A GVP   + W K+   L P +         +L +  V  +D   Y C+A NS GS
Sbjct: 3692 LPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 3751

Query: 435  NQASARLVVTGGPEPP 450
            ++    L V    EPP
Sbjct: 3752 DRQGRDLRVL---EPP 3764



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 115/481 (23%), Positives = 170/481 (35%), Gaps = 90/481 (18%)

Query: 36   LVLPCQVEGEPPVSISWQRDR---------------LALANESGVTLMPDG-SLHLAALP 79
            L L C   G P   I W +D                L      G  L+ +G SLH   + 
Sbjct: 1318 LTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 1377

Query: 80   SRRS--LPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCL 137
               S     RA      AQ  +  LV     V  A  ++        +VE       QC 
Sbjct: 1378 EGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVE------LQCW 1431

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHS 196
              GVP P + W  +   +      + +   G +L IT     D G Y+CVA++ A  + +
Sbjct: 1432 TSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG-QQA 1490

Query: 197  QDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLE--CIATSHPWPLVSWSRLDGRS 254
            +D Q       LR+   P I    +   + V +  +++  C A   P P ++W + DG  
Sbjct: 1491 RDFQ-------LRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFK-DGAL 1542

Query: 255  IGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAAN----------RPGTHVRRTAQG--- 301
            +     +V+       L +       +GVY C A+          R   +V  T +G   
Sbjct: 1543 LPT-STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG 1601

Query: 302  ----VLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRG----------SRAGGKRLGLTAP- 346
                V  V G P     V R   HPS  T +W   G              G  L L +P 
Sbjct: 1602 RPYVVKAVAGRPVALECVAR--GHPSP-TLSWHHEGLPVAESNESRLETDGSVLRLESPG 1658

Query: 347  --SSMLL------PA-----QLPEFVQWPQSLSKPPGSSAIFT---------CVAQGVPE 384
              SS L       PA     Q    VQ P  L    G   + T         C A G P 
Sbjct: 1659 EASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPV 1718

Query: 385  SRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVT 444
              + WL+NG+       +++    +TL +  V ++   ++ C A N  G+  A   + V 
Sbjct: 1719 PTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH 1778

Query: 445  G 445
            G
Sbjct: 1779 G 1779



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 2/68 (2%)

Query: 408 NSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP--PRPQGPACHGSLYFCH 465
           NS+  +   S  +E  Y+C A +  G+ +A A++VVT  P    P P      G      
Sbjct: 478 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 537

Query: 466 SSVLGATP 473
             VLG  P
Sbjct: 538 CRVLGEAP 545


>gi|19743806 roundabout 1 isoform b [Homo sapiens]
          Length = 1612

 Score =  139 bits (351), Expect = 6e-33
 Identities = 142/506 (28%), Positives = 207/506 (40%), Gaps = 91/506 (17%)

Query: 22  VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
           V+   D +     P  L C+ EG P  +I W +    +  +     S   L+P GSL  L
Sbjct: 32  VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91

Query: 76  AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL-SRFHQHPESIEVERGGVACF 134
             +  R+S P     Y CVA+N  G  VS  A +++A L   F Q+P  + V  G  A  
Sbjct: 92  RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 150

Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           +C   +G PEP+ISW+ +G+ L+  + R+T+   G L IT   ++D G Y CV  N+   
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 209

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
           R S+ A+LT+       L+ P  +  P NL +TV  +A  +C A   P P V W + DG 
Sbjct: 210 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262

Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
                     +I D   L I  V+    G Y C A N  G   +  A   L VQ EP  P
Sbjct: 263 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQ-EP--P 312

Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
           ++V          GR +      TG    A  WR                 SR    + G
Sbjct: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372

Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
                              L    S++  A L           P   Q P + +     +
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432

Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
            + +CVA G P   ++W K+G ++S  ++      N  L +    + D   Y C+A   +
Sbjct: 433 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 492

Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
           G    SA + V   G P +PPRP  P
Sbjct: 493 GEATWSAYIEVQEFGVPVQPPRPTDP 518



 Score =  100 bits (249), Expect = 4e-21
 Identities = 97/347 (27%), Positives = 139/347 (40%), Gaps = 76/347 (21%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
           R  +HP  + V +G  A   C  +G P P+I W   G  + T      +HR+ LLPSG L
Sbjct: 30  RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 88

Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
               +     S+ D G Y CVA N      S +A L +++         +    P ++ +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 142

Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
            V + AV+EC     HP P +SW + DG  +  +  ++   +  G LMI+      +G Y
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 199

Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
           VC                        G N VG      + LT                  
Sbjct: 200 VCV-----------------------GTNMVGERESEVAELT------------------ 218

Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
                    + P FV+ P +L+     SA F C A+G P   + W K +G++      IR
Sbjct: 219 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271

Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
             H   TL +  V+  D   Y CVAEN  G  +ASA L V    EPP
Sbjct: 272 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV---QEPP 312



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 81/309 (26%), Positives = 129/309 (41%), Gaps = 24/309 (7%)

Query: 20  AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
           +FV+   +     +      C+  G+P  ++ W++D   L  +S   +  D +L +    
Sbjct: 224 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 278

Query: 80  SRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQ 139
            R+        Y CVA+N  G+     A + +     F   P    V  G    FQC   
Sbjct: 279 -RKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 336

Query: 140 GVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAS 192
           G P+P+I W   G+           ++ R ++  +G L IT+V ++D+G Y C   NVA 
Sbjct: 337 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 396

Query: 193 TRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDG 252
           +  ++       V   R    P I  GP N T+ V  T VL C+AT  P P + W R DG
Sbjct: 397 SIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDG 453

Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLLVQ 306
             +  +  ++   L+ G L I    +  +G Y C A+ P      +A       GV +  
Sbjct: 454 VLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 512

Query: 307 GEPQGPNWV 315
             P  PN +
Sbjct: 513 PRPTDPNLI 521



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)

Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
           P  V+ P  L    G  A   C A+G P   + W K G+ +      P ++  L  + S 
Sbjct: 29  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88

Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
             L  V    S  DE +Y CVA N  G   S+ AS  + +
Sbjct: 89  FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 128


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score =  139 bits (351), Expect = 6e-33
 Identities = 129/462 (27%), Positives = 195/462 (42%), Gaps = 63/462 (13%)

Query: 30   AVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
            AV E  ++LPC+  G P  +I+WQ++ L +A      ++P G L +A      + P  A 
Sbjct: 2677 AVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIA-----HASPEDAG 2731

Query: 90   EYHCVAQNRYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISW 148
             Y C+A+N  G  + + R  VQ+  +         +    G  A   C  +G PEP+I+W
Sbjct: 2732 NYLCIAKNSAGSAMGKTRLVVQVPPV--IENGLPDLSTTEGSHAFLPCKARGSPEPNITW 2789

Query: 149  EHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPL 208
            + +G  ++ A  + T+ PSG L + ++   D GTY C A N A  R  +   LT+ V P+
Sbjct: 2790 DKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAEN-AVGRARRRVHLTILVLPV 2848

Query: 209  RLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
                     + P + +L +     L C A   P P + W+ ++ R +  EG+   D    
Sbjct: 2849 -------FTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-TEGVSEQD--GG 2897

Query: 269  GNLMISDVSVQHSGVYVC-AANRPG-------THVRR------------------TAQGV 302
              L  + VS + SG YVC A NR G        HV+                   + Q  
Sbjct: 2898 STLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLD 2957

Query: 303  LLVQGEP-QGPNWV-------GRVLEHPSSLTGAWIWRGSRAGGKR--------LGLTAP 346
             +V+G+P    +W+       G  L H        I R  R    R        +G+   
Sbjct: 2958 CVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKK 3017

Query: 347  SSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTH 406
              +L+    P F   PQ ++   G      C A G P   + WL+ G+ L     +R T 
Sbjct: 3018 VVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLR-TL 3076

Query: 407  NNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
             + +L L  V   D   Y CVA N  GS  A A LVV G P+
Sbjct: 3077 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQ 3118



 Score =  139 bits (350), Expect = 8e-33
 Identities = 149/545 (27%), Positives = 216/545 (39%), Gaps = 72/545 (13%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGS-LHLAALPSRRSLPSRAHEYHCV 94
            LVL C VE EP   I+W RD + L  ++       G  L L AL +  S      +Y C 
Sbjct: 2317 LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADS-----GDYSCT 2371

Query: 95   AQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTA 154
            A+N  G   S   RV++ ++      P ++ V     A   C   GVP P +SW  +   
Sbjct: 2372 ARNAAGS-TSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVP 2430

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA-STRHSQDAQLTLSVGPLRLLQE 213
            L+  + R  +LP G L I  V   D G Y C+A N A S R  +D         LR+L+ 
Sbjct: 2431 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRD---------LRVLEP 2481

Query: 214  PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ-VLDILDTGNLM 272
            P I   P NLTLT H  A+L C A+  P PLV W + DG+ +     Q    +L +  L+
Sbjct: 2482 PAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK-DGQKLDFRLQQGAYRLLPSNALL 2540

Query: 273  ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ---GEPQGPNWVGRVLE-----HPSS 324
            ++    Q S  + C  +       R  Q  + V     + Q    V  +       H + 
Sbjct: 2541 LTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTG 2600

Query: 325  L---TGAWIWRGSRAGGKRLGL-TAPSSMLLPAQL------------------------- 355
            +   T +W   G++ G +  G   +PS  L   Q                          
Sbjct: 2601 IPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFL 2660

Query: 356  -----PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNST 410
                 P     P  +        +  C A G+P   + W K G  ++ G + ++      
Sbjct: 2661 TVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQ- 2719

Query: 411  LMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP--EPPRPQGPACHGSLYFCHSSV 468
            L +A  S ED   Y C+A+NS GS     RLVV   P  E   P      GS  F     
Sbjct: 2720 LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKA 2779

Query: 469  LGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSA 528
             G+  P+    I +    +PV   SG E +  I + + E +  NLE   A T    A +A
Sbjct: 2780 RGSPEPN----ITWDKDGQPV---SGAEGKFTI-QPSGELLVKNLEGQDAGTYTCTAENA 2831

Query: 529  EGASQ 533
             G ++
Sbjct: 2832 VGRAR 2836



 Score =  108 bits (270), Expect = 2e-23
 Identities = 139/603 (23%), Positives = 215/603 (35%), Gaps = 99/603 (16%)

Query: 24  ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
           E G+   + +H + L C+  G P  +I+W +D   L   + V     G      L   R+
Sbjct: 226 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGR----QLQLGRA 281

Query: 84  LPSRAHEYHCVAQNRYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACFQCLIQG 140
             S A  Y C A N  G    +  R+ +    ++      P  ++   G     +C+ +G
Sbjct: 282 QSSDAGVYTCKASNAVGA-AEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARG 340

Query: 141 VPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQ 200
            P P++SW H G  +  +N         +L + S  +   G Y CVA + A     Q   
Sbjct: 341 HPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQ-YS 399

Query: 201 LTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
           + + V P  L+ E     G   +T  V Q   L C A+  P P + W +    +  + G+
Sbjct: 400 VEVQVPPQLLVAE-----GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGV 454

Query: 261 QVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
           QV     T  L I  V + HSG++ C A N  GT     A+  + V GE     W   VL
Sbjct: 455 QVASQGTT--LHIDHVELDHSGLFACQATNEAGT---AGAEVEVSVHGE-----WAPGVL 504

Query: 320 -----------EHPSSLTGA--------------------WIWRGSRAGGKRLGLTAPSS 348
                      EH SS   A                    W   GS   G+  G+    S
Sbjct: 505 EVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 563

Query: 349 MLLPAQL---------------------------------PEFVQWPQSLSKPPGSSAIF 375
           +  P Q+                                 P     P + +    +S   
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTL 623

Query: 376 TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
            C+A GVP   + W K  + +S    + ++ +   L +    + D   Y+CVA N  GS 
Sbjct: 624 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 683

Query: 436 QASARLVVTGGPE---PPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEP 492
           +    L V   P    PP   GP    +      +  GA  P+    + ++    PV   
Sbjct: 684 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPT----LMWLKDGNPVSPA 739

Query: 493 SGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIFASTMGSNLGEALN 552
             P LQ  +  G      ++   + +      A SA G  +    +      S LGE LN
Sbjct: 740 GTPGLQ--VFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELN 797

Query: 553 LPV 555
           + V
Sbjct: 798 VSV 800



 Score =  107 bits (267), Expect = 3e-23
 Identities = 113/408 (27%), Positives = 165/408 (40%), Gaps = 85/408 (20%)

Query: 35   PLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
            P+ L C  +G P  +I+W +D  AL      T + + S     L  R      A  Y C+
Sbjct: 2230 PMELLCDAQGTPQPNITWHKDGQAL------TRLENNSRATRVLRVRD-----AGLYTCL 2278

Query: 95   AQNRYGRLV-SRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGT 153
            A++  G +  S R RVQ        + P  +     G    +C ++  P P I+W  +G 
Sbjct: 2279 AESPAGAIEKSFRVRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGI 2338

Query: 154  ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQE 213
             L    H         L + ++S  D G Y C A N A +        T     + +   
Sbjct: 2339 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGS--------TSVAFRVEIHTV 2390

Query: 214  PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSR----LDGRSIGVEGIQVLDILDTG 269
            P I SGP  + ++V+QTA+L C A   P PLVSW +    LD RS   E      IL  G
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFE------ILPEG 2444

Query: 270  NLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
            +L I  V  Q +G Y+C A+N  G+              + QG +   RVLE P+     
Sbjct: 2445 SLRIQPVLAQDAGHYLCLASNSAGS--------------DRQGRDL--RVLEPPAI---- 2484

Query: 329  WIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLV 388
                            +PS++ L A  P                A+  C A G P+  +V
Sbjct: 2485 --------------APSPSNLTLTAHTP----------------ALLPCEASGSPKPLVV 2514

Query: 389  WLKNGKVLS---PGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
            W K+G+ L         RL  +N+ L+L     +D A ++CV  N  G
Sbjct: 2515 WWKDGQKLDFRLQQGAYRLLPSNA-LLLTAPGPQDSAQFECVVSNEVG 2561



 Score =  102 bits (254), Expect = 1e-21
 Identities = 113/458 (24%), Positives = 163/458 (35%), Gaps = 64/458 (13%)

Query: 35   PLVLPCQVEGEPPVSISWQRDRLAL---ANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
            P +LPC+  G P   + W +D   L     +    L+P  +L L A P     P  + ++
Sbjct: 2498 PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTA-PG----PQDSAQF 2552

Query: 92   HCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHN 151
             CV  N  G    R  +V +              V         C   G+P P++SW   
Sbjct: 2553 ECVVSNEVGE-AHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKA 2611

Query: 152  GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
            G  L        + PSG L I        G Y C A N A   H +   LT+   P+   
Sbjct: 2612 GAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH-KHVFLTVQASPV--- 2667

Query: 212  QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
                +   P  +     +  +L C A+  P P ++W + +G ++   G+    +L  G L
Sbjct: 2668 ----VKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQK-EGLNVAT-GVST-QVLPGGQL 2720

Query: 272  MISDVSVQHSGVYVC-AANRPGTHVRRTAQGV----LLVQGEPQGPNWVGRVLEHPSSLT 326
             I+  S + +G Y+C A N  G+ + +T   V    ++  G P      G     P    
Sbjct: 2721 RIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKAR 2780

Query: 327  GA------WIWRGSRAGGKRLGLT-APSSMLLPAQ------------------------- 354
            G+      W   G    G     T  PS  LL                            
Sbjct: 2781 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2840

Query: 355  -----LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNS 409
                 LP F   P   S   G      C A+G P  R+ W  N + ++ G  +      S
Sbjct: 2841 LTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEG--VSEQDGGS 2898

Query: 410  TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
            TL  A VS ED   Y C AEN  G  QA + + V   P
Sbjct: 2899 TLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP 2936



 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 108/416 (25%), Positives = 161/416 (38%), Gaps = 66/416 (15%)

Query: 23   QELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRR 82
            +EL  +V   E  + L CQ    PP  +SW +D   L    GV L  D +L    L   R
Sbjct: 794  EELNVSVVANES-VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKAL----LQVDR 848

Query: 83   SLPSRAHEYHCVAQNRYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
            +    A  Y C A N+ G         V +A +    +   ++ V  G      C  +GV
Sbjct: 849  ADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRES-HTLTVREGHPTRLSCECRGV 907

Query: 142  PEPSISWEHNGTAL--NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
            P P ISW  +G  L    A  +       +L++        GTY C   NV     SQD 
Sbjct: 908  PFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG-NSSQDL 966

Query: 200  QLTLSVGP-LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
            QL + V P +   +EP     P  +++     A LEC AT  P P V+W R DG+ +G E
Sbjct: 967  QLEVHVPPQIAGPREP-----PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAE 1020

Query: 259  -GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGR 317
             G+Q+ +     +L +      H+G Y C A        R  +  +LV  E  G      
Sbjct: 1021 LGLQLQN--QGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGD----- 1073

Query: 318  VLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTC 377
             L+  +++T A              L +P ++L                          C
Sbjct: 1074 -LDPLTNITAA--------------LHSPLTLL--------------------------C 1092

Query: 378  VAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
             A G+P   + W +  + +SPG +  L      L +     +D  +Y C+A N  G
Sbjct: 1093 EAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG 1148



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 138/552 (25%), Positives = 200/552 (36%), Gaps = 95/552 (17%)

Query: 24   ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
            +L    A+    + LPC V   P   ++W +D  AL+    V L+P        L   R+
Sbjct: 1661 DLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH----TLQLGRA 1716

Query: 84   LPSRAHEYHCVAQNRYGRLVSRRARVQLASL--SRFHQHP----ESIEVERGGVACFQCL 137
              S +  Y C A N  GR    +  VQL+ L    F Q P    +++ V  G  A   C 
Sbjct: 1717 RLSDSGMYTCEALNAAGR---DQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCE 1773

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
               +PEP+++W  +G  L  A     L     L I     +D G Y C   NVA      
Sbjct: 1774 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG----- 1828

Query: 198  DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA----VLECIATSHPWPLVSW--SRLD 251
            +A  T ++     +Q P     P+  T TV Q A    VL C  +  P P V+W   R+ 
Sbjct: 1829 EAVRTFTL----TVQVPPTFENPK--TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 1882

Query: 252  GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
              S  V G+    +   G L +S +    +G Y C A       R+     +LV    + 
Sbjct: 1883 VESSAVHGV----VSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRS 1938

Query: 312  PNWV-------GRVLEHPSSLTG------AWIWRGSRAG---GKRL------------GL 343
                       G+ +       G      AW+  GS  G   G  L            GL
Sbjct: 1939 SGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGL 1998

Query: 344  TAPS---------------------SMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
             A                       ++L+P  + +      +L   PG      C  +G 
Sbjct: 1999 RASDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGS 2058

Query: 383  PESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
            P   + WLK+G  L       L  +  TL ++ V + D  I+ CVA +  G    +  L 
Sbjct: 2059 PPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 2118

Query: 443  VTGGP--EPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPS---GP 495
            V   P  EP   Q       GSL        G   P    ++ ++    P+   S   GP
Sbjct: 2119 VQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLP----LVSWMKDGEPLLSQSLEQGP 2174

Query: 496  ELQ-EAISKGTS 506
             LQ EA+  G S
Sbjct: 2175 SLQLEAVGAGDS 2186



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 112/426 (26%), Positives = 167/426 (39%), Gaps = 82/426 (19%)

Query: 38   LPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAHEYHCV 94
            L C+ +G+PP  ++W +D   L  + G  L   +  GSL L  L +     S A  Y CV
Sbjct: 1955 LDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA-----SDAGAYTCV 2009

Query: 95   AQNRYGRLVSRRARVQLASLSRFHQHPE---SIEVERGGVACFQCLIQGVPEPSISWEHN 151
            A N  G   +R   V +       Q  +   ++    G +    C ++G P   +SW  +
Sbjct: 2010 AHNPAGE-DARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 2068

Query: 152  GTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
            G  L   + R  L  SG  L I+ V   D G + CVA   AS     D   TL V    +
Sbjct: 2069 GLPL-PLSQRTLLHGSGHTLRISKVQLADAGIFTCVA---ASPAGVADRNFTLQVQVPPV 2124

Query: 211  LQEPEILSGPQNLTLTVHQTAV-LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTG 269
            L+  E     QN  + V  + V L C A   P PLVSW + DG  +  + ++        
Sbjct: 2125 LEPVEF----QNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLE-----QGP 2174

Query: 270  NLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAW 329
            +L +  V    SG Y C A       RR  Q                             
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------------------------- 2205

Query: 330  IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW 389
                              +++ P  + +  Q P  LS  PG+     C AQG P+  + W
Sbjct: 2206 -----------------LTVMEPPHIEDSGQ-PTELSLTPGAPMELLCDAQGTPQPNITW 2247

Query: 390  LKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
             K+G+ L+     RL +N+    +  + V D  +Y C+AE+  G+ + S R+ V   P  
Sbjct: 2248 HKDGQALT-----RLENNSRATRV--LRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPNI 2300

Query: 450  PRPQGP 455
              P+GP
Sbjct: 2301 VGPRGP 2306



 Score = 97.1 bits (240), Expect = 5e-20
 Identities = 131/596 (21%), Positives = 217/596 (36%), Gaps = 88/596 (14%)

Query: 31   VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
            V  +P  L C     PP  ++W R+   L+    V+++  G   +  +P  R+    A  
Sbjct: 1481 VENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG--RVLQIPLVRA--ENAGR 1536

Query: 91   YHCVAQNRYGRLVSRRARVQLAS---LSRFHQHPESIEVERGGVACFQCLIQGVPEPSIS 147
            Y C A N  G        + L     L    +  E + V        QC   G P P+IS
Sbjct: 1537 YSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTIS 1596

Query: 148  WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
            W  NG   + +     L    +L +++    D  +Y CVA N A    S +   TL V  
Sbjct: 1597 WLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG---SAEKLFTLRV-- 1651

Query: 208  LRLLQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDI 265
                Q P  ++G   + +T  ++ +  L C   +HP P V+W + D +++ + G +V  +
Sbjct: 1652 ----QVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK-DSQALSL-GEEVFLL 1705

Query: 266  LDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLV----QGEPQGPNWVGRVLEH 321
              T  L +    +  SG+Y C A       ++  Q  +LV    +  P+GP     V   
Sbjct: 1706 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1765

Query: 322  PSSL-----------TGAWIWRG----------SRAGGKRLGL----------------- 343
              ++           T  W   G          +  GG+RL +                 
Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSN 1825

Query: 344  ---TAPSSMLLPAQLPEFVQWP--QSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
                A  +  L  Q+P   + P  +++S+  GS  + TC   GVP   + WLK+   +  
Sbjct: 1826 VAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1885

Query: 399  GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPA-- 456
                 +      L L+ +       Y CVAEN+    +    + V   P   R  G A  
Sbjct: 1886 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPR-IRSSGVARE 1944

Query: 457  ---CHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNL 513
                 G          G  PP     + ++    P+G+  GP L+  +  G+        
Sbjct: 1945 HHVLEGQEVRLDCEADGQPPPD----VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 2000

Query: 514  EPATAYTIHLRAYSAEGASQDSAPIF-----------ASTMGSNLGEALNLPVPLK 558
              A AYT      + E A   +  +            + T+ S  GE + +  P++
Sbjct: 2001 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVR 2056



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 119/495 (24%), Positives = 187/495 (37%), Gaps = 102/495 (20%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            + L C   G PP  +SW +    +++  GVT+  DG +    L   ++  S A  Y CVA
Sbjct: 621  VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRV----LRIEQAQLSDAGSYRCVA 676

Query: 96   QN-------RYGRLVSRRARVQLASLSRFHQHPESIE--VERGGVACFQCLIQGVPEPSI 146
             N       RYG  V+   R+ L         P S+   V         C   G P P++
Sbjct: 677  SNVAGSTELRYGLRVNVPPRITL---------PPSLPGPVLVNTPVRLTCNATGAPSPTL 727

Query: 147  SWEHNGTALNTANHR-VTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
             W  +G  ++ A    + + P G +L + S   +D G Y CVA +       +D Q  + 
Sbjct: 728  MWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVG----EDRQDVV- 782

Query: 205  VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE-GIQVL 263
               L++   P IL    N+++  +++  LEC + + P P++SW + DGR +    G+ + 
Sbjct: 783  ---LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWK-DGRPLEPRPGVHL- 837

Query: 264  DILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHP 322
               D   L +    V  +G Y C A N+ G   +     V           WV  V    
Sbjct: 838  -SADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNV-----------WVAPVFPLR 885

Query: 323  SSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGV 382
             S T                                      L+   G     +C  +GV
Sbjct: 886  ESHT--------------------------------------LTVREGHPTRLSCECRGV 907

Query: 383  PESRLVWLKNGKVLSPGNNIRLTHNNST---LMLAGVSVEDEAIYQCVAENSTGSNQASA 439
            P  ++ W K+G+ L PG    L H ++    L L    +  E  Y C   N  G++    
Sbjct: 908  PFPKISWRKDGQPL-PGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDL 966

Query: 440  RLVV-----TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSG 494
            +L V       GP  P  Q       +     +  G  PP+    + +    +PVG   G
Sbjct: 967  QLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPT----VTWERDGQPVGAELG 1022

Query: 495  PELQEAISKGTSEHV 509
             +LQ   ++G S HV
Sbjct: 1023 LQLQ---NQGQSLHV 1034



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 95/421 (22%), Positives = 156/421 (37%), Gaps = 68/421 (16%)

Query: 34   HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP----SRAH 89
            HP  L C+  G P   ISW++D   L  E        G  H++A+     L     ++  
Sbjct: 896  HPTRLSCECRGVPFPKISWRKDGQPLPGEGA------GLQHVSAVGRLLYLGQAQLAQEG 949

Query: 90   EYHCVAQNRYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSI 146
             Y C   N  G   S+  ++++     ++   + P  + V + GVA  +C   G P P++
Sbjct: 950  TYTCECSNVVGNS-SQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTV 1008

Query: 147  SWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVG 206
            +WE +G  +              LH+        G Y CVA N+A  R  +  +L++ V 
Sbjct: 1009 TWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG-RAERKFELSVLVP 1067

Query: 207  PLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDIL 266
            P  L+ + + L+   N+T  +H    L C A   P P + W R  G      G     + 
Sbjct: 1068 P-ELIGDLDPLT---NITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLA 1121

Query: 267  DTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
                L ++    Q SG+Y C A+      RR               N+   VL  PS   
Sbjct: 1122 GGWMLKMTQTQEQDSGLYSCLASNEAGEARR---------------NFSVEVLVPPSI-- 1164

Query: 327  GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
                                          E     + +    G +A   C   G P+ +
Sbjct: 1165 ------------------------------ENEDLEEVIKVLDGQTAHLMCNVTGHPQPK 1194

Query: 387  LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
            L W K+G+ L+ G+   ++ +   L +   ++     Y C+A N+ G      +L V   
Sbjct: 1195 LTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLA 1254

Query: 447  P 447
            P
Sbjct: 1255 P 1255



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 101/415 (24%), Positives = 163/415 (39%), Gaps = 83/415 (20%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            + + C V G PP+ +SW +D L L       L   GS H   + S+  L + A  + CVA
Sbjct: 2049 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL--HGSGHTLRI-SKVQL-ADAGIFTCVA 2104

Query: 96   QNRYGRLVSRR---ARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNG 152
             +  G  V+ R    +VQ+  +    +    + V RG +    C  +GVP P +SW  +G
Sbjct: 2105 ASPAG--VADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDG 2162

Query: 153  TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVA--STRHSQDAQLTLSVGPLRL 210
              L +     +L     L + +V   D GTY CVA + A  + RH Q          L +
Sbjct: 2163 EPLLSQ----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQ----------LTV 2208

Query: 211  LQEPEILSG--PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
            ++ P I     P  L+LT      L C A   P P ++W + DG        Q L  L+ 
Sbjct: 2209 MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHK-DG--------QALTRLEN 2259

Query: 269  GNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
             +     + V+ +G+Y C A  P   + ++                              
Sbjct: 2260 NSRATRVLRVRDAGLYTCLAESPAGAIEKSF----------------------------- 2290

Query: 329  WIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLV 388
                       R+ + AP +++ P + P FV     +   PG   +  C  +  P  ++ 
Sbjct: 2291 -----------RVRVQAPPNIVGP-RGPRFV-----VGLAPG-QLVLECSVEAEPAPKIT 2332

Query: 389  WLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            W ++G VL    + +       L L  +S  D   Y C A N+ GS   + R+ +
Sbjct: 2333 WHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2387



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 111/460 (24%), Positives = 174/460 (37%), Gaps = 81/460 (17%)

Query: 16   GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHL 75
            G+E +  +E+  TV    +P+ L C+    P  +I+W +D         + L+P G+  L
Sbjct: 1260 GAEDSADEEVTVTV---NNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLP-GTHGL 1315

Query: 76   AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHP------ESIEVERG 129
              L +++     A +Y CV  N  G  V       L   S     P      + ++ +  
Sbjct: 1316 QILNAQKE---DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVN 1372

Query: 130  GVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
                 +C    VP P+I W  +G  +  ++    L    +L I     +D G Y CVA N
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432

Query: 190  VASTRHSQDAQLTLSVGPL------------RLLQEPEILSG-PQNLTLTVHQTAVLECI 236
            VA     QD  + + V P+             L +E E   G  +   +  +  A L C 
Sbjct: 1433 VAG-EDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCD 1491

Query: 237  ATSHPWPLVSWSRLD-GRSIGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTH 294
              + P P ++W R D   S G E    + +L  G  L I  V  +++G Y C A+     
Sbjct: 1492 TNAIPPPDLTWYREDQPLSAGDE----VSVLQGGRVLQIPLVRAENAGRYSCKAS----- 1542

Query: 295  VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
                            G +W+   L                     L LT P   ++   
Sbjct: 1543 -------------NEVGEDWLHYEL---------------------LVLTPP---VILGD 1565

Query: 355  LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
              E V   + ++    S+    C A G P   + WL+NG   SP   +++  +   L ++
Sbjct: 1566 TEELV---EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 1622

Query: 415  GVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQG 454
               V D A Y CVAEN  GS   + +L       PPR  G
Sbjct: 1623 TAEVADAASYMCVAENQAGS---AEKLFTLRVQVPPRIAG 1659



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 99/437 (22%), Positives = 161/437 (36%), Gaps = 78/437 (17%)

Query: 25   LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
            L +  A    PL L C+  G PP +I W R    ++      L+  G +    L   ++ 
Sbjct: 1077 LTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM----LKMTQTQ 1132

Query: 85   PSRAHEYHCVAQNRYGRLVSRR---ARVQLASLSRFHQHPESIEVERGGVACFQCLIQGV 141
               +  Y C+A N  G   +RR     V +          E I+V  G  A   C + G 
Sbjct: 1133 EQDSGLYSCLASNEAGE--ARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGH 1190

Query: 142  PEPSISWEHNGTAL--NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVA--STRHS 196
            P+P ++W  +G  L    A+H   + P G+ L +   + +  G Y C+A N     T+H 
Sbjct: 1191 PQPKLTWFKDGRPLARGDAHH---ISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHF 1247

Query: 197  QDAQLTLSVGPLRLLQEPEILSGPQN-----LTLTVHQTAVLECIATSHPWPLVSWSRLD 251
            Q          L +L  P IL G ++     +T+TV+    L C A + P P ++W +  
Sbjct: 1248 Q----------LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDG 1297

Query: 252  GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQ 310
                    IQ+L    T  L I +   + +G Y C   N  G  V+     VL+      
Sbjct: 1298 APFEASRNIQLLP--GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI------ 1349

Query: 311  GPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPG 370
                                               P S+     L E     + +     
Sbjct: 1350 -----------------------------------PPSISKDDPLAEV--GVKEVKTKVN 1372

Query: 371  SSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAEN 430
            S+    C +  VP   + W K+G+ ++P + +++      L +    V D   Y CVA N
Sbjct: 1373 STLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATN 1432

Query: 431  STGSNQASARLVVTGGP 447
              G +     +++   P
Sbjct: 1433 VAGEDDQDFNVLIQVPP 1449



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 81/278 (29%), Positives = 115/278 (41%), Gaps = 24/278 (8%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            L L C   G P   I W  +   +    GV+    GS    A  SR      +  Y C A
Sbjct: 2864 LWLRCAARGSPTPRIGWTVNDRPVTE--GVSEQDGGSTLQRAAVSRED----SGTYVCWA 2917

Query: 96   QNRYGRLVSRRARVQLASLSRFHQHPESIEVER-GGVACFQCLIQGVPEPSISWEHNGTA 154
            +NR GR     + V +           S  VE  GG     C+++G P P I W  +G  
Sbjct: 2918 ENRVGR-TQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLP 2976

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
            L   +H    L +G L I    + D G Y+C+A N        +  +   V  L L   P
Sbjct: 2977 LR-GSHLRHQLQNGSLTIRRTERDDAGRYQCLAEN--------EMGVAKKVVILVLQSAP 3027

Query: 215  EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
                 PQ++T+       L C AT  P P + W +  G+ +     + L  L  G+L + 
Sbjct: 3028 VFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQA-GQPLRAS--RRLRTLPDGSLWLE 3084

Query: 275  DVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQG 311
            +V    +G Y C A N  G+    TA+  L+V+GEPQG
Sbjct: 3085 NVETGDAGTYDCVAHNLLGS---ATARAFLVVRGEPQG 3119



 Score = 79.7 bits (195), Expect = 8e-15
 Identities = 109/452 (24%), Positives = 162/452 (35%), Gaps = 99/452 (21%)

Query: 18  ELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDG-SLHLA 76
           +L   + LG    +   PL LPCQ  G P  +I W ++       +GV +   G +LH+ 
Sbjct: 407 QLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHID 466

Query: 77  ALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLA------------SLSRFH---QHP 121
            +    S       + C A N  G   +  A V+++             + ++H   +H 
Sbjct: 467 HVELDHS-----GLFACQATNEAG---TAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHH 518

Query: 122 ESI------EVERG-GVACFQCLIQGVPEPSISW-EHNGTALNTANHRVTLLPSGILHIT 173
            S        V RG G      L++G   P   W E  G  +       +L P   L I 
Sbjct: 519 SSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPV-----AYSLPPP--LQIE 571

Query: 174 SVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVL 233
            V   D G Y C A N+A     + A        L++L  P I  GP N  +  + +  L
Sbjct: 572 KVDLRDEGIYTCAATNLAGESKREVA--------LKVLVPPNIEPGPVNKAVLENASVTL 623

Query: 234 ECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGT 293
           EC+A+  P P VSW +  G       + V   +D   L I    +  +G Y C A+    
Sbjct: 624 ECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA- 680

Query: 294 HVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPA 353
                                                  GS      L +  P  + LP 
Sbjct: 681 ---------------------------------------GSTELRYGLRVNVPPRITLPP 701

Query: 354 QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN--NIRLTHNNSTL 411
            LP     P  ++ P       TC A G P   L+WLK+G  +SP     +++      L
Sbjct: 702 SLP----GPVLVNTP----VRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVL 753

Query: 412 MLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            LA     D   Y CVA ++ G ++    L V
Sbjct: 754 TLASARASDSGRYSCVAVSAVGEDRQDVVLQV 785



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 91/414 (21%), Positives = 142/414 (34%), Gaps = 68/414 (16%)

Query: 38  LPCQVEGEPPVSISWQRDRL-ALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQ 96
           L C   G P   + W +DR   L     + +  DG +    L    S       Y CVA 
Sbjct: 146 LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQV----LRITGSHVGDEGRYQCVAF 201

Query: 97  NRYGRLV-SRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTAL 155
           +  G+     + RV              + V    +    C  +GVP P+I+W  +G  L
Sbjct: 202 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 261

Query: 156 NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPE 215
            T+   V       L +     +D G Y C A N       +  +L + V        P 
Sbjct: 262 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAA-EKATRLDVYV--------PP 312

Query: 216 ILSG----PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
            + G    P  +     +   LEC+A  HP P +SW   +G  +       L+  D   L
Sbjct: 313 TIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHH-EGLPVAESNESRLE-TDGSVL 370

Query: 272 MISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIW 331
            +       SG+Y C A+ P        + VL    E Q P         P  L    + 
Sbjct: 371 RLESPGEASSGLYSCVASSP------AGEAVLQYSVEVQVP---------PQLLVAEGLG 415

Query: 332 RGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK 391
           + +   G+            P +LP                    C A G P   + WL+
Sbjct: 416 QVTTIVGQ------------PLELP--------------------CQASGSPVPTIQWLQ 443

Query: 392 NGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTG 445
           NG+       +++    +TL +  V ++   ++ C A N  G+  A   + V G
Sbjct: 444 NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 497



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 107/436 (24%), Positives = 156/436 (35%), Gaps = 88/436 (20%)

Query: 22   VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSR 81
            V+   D V V    + LPC+  G P   +SW +D   L ++S   L    SL L A+ + 
Sbjct: 2128 VEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQS---LEQGPSLQLEAVGAG 2184

Query: 82   RSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFH----QHPESIEVERGGVACFQCL 137
             S       Y CVA +  G     R   QL  +   H      P  + +  G      C 
Sbjct: 2185 DS-----GTYSCVAVSEAG---EARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCD 2236

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQ 197
             QG P+P+I+W  +G AL       T L +       +   D G Y C+A + A      
Sbjct: 2237 AQGTPQPNITWHKDGQAL-------TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKS 2289

Query: 198  DAQLTLSVGPLRLLQEPEILS--GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
                      +R+   P I+   GP+ +        VLEC   + P P ++W R DG  I
Sbjct: 2290 FR--------VRVQAPPNIVGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR-DG--I 2338

Query: 256  GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
             ++        + G  L +  +S   SG Y C A        R A G   V         
Sbjct: 2339 VLQEDAHTQFPERGRFLQLQALSTADSGDYSCTA--------RNAAGSTSV--------- 2381

Query: 315  VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
              RV  H                                 +P     P +++     +A+
Sbjct: 2382 AFRVEIH--------------------------------TVPTIRSGPPAVNVSVNQTAL 2409

Query: 375  FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
              C A GVP   + W K+   L P +         +L +  V  +D   Y C+A NS GS
Sbjct: 2410 LPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGS 2469

Query: 435  NQASARLVVTGGPEPP 450
            ++    L V    EPP
Sbjct: 2470 DRQGRDLRVL---EPP 2482



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 82/329 (24%), Positives = 109/329 (33%), Gaps = 79/329 (24%)

Query: 135 QCLIQGVPEPSISWEHN----GTALNTAN------------HRVTLLPSG-ILHITSVSQ 177
           +C   G P P I W  +    G  L  A             HR  LL  G  LH   + +
Sbjct: 39  ECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHR--LLDEGQSLHFPRIQE 96

Query: 178 TDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEIL--SGPQNLTLTVHQTAVLEC 235
            D G Y C A N A T     AQ       L +L  P +L     Q +         L+C
Sbjct: 97  GDSGLYSCRAENQAGT-----AQRDFH---LLVLTPPSVLGAGAAQEVLGLAGADVELQC 148

Query: 236 IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTH 294
             +  P P V W++   R   + G   L + + G  L I+   V   G Y C A  P   
Sbjct: 149 WTSGVPTPQVEWTK--DRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206

Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
             R  Q  L V   P                    IW GS   G+   +      LL   
Sbjct: 207 QARDFQ--LRVHAPPT-------------------IW-GSNETGEVAVMEDHLVQLL--- 241

Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
                                 C A+GVP   + W K+G +L     +  T     L L 
Sbjct: 242 ----------------------CEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLG 279

Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVV 443
                D  +Y C A N+ G+ + + RL V
Sbjct: 280 RAQSSDAGVYTCKASNAVGAAEKATRLDV 308



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 59/241 (24%), Positives = 90/241 (37%), Gaps = 63/241 (26%)

Query: 222 NLTLTVHQTAVLECIATSHPWPLVSW---SRLDGRSIGVEG---------IQVLDILDTG 269
           N++    Q+  LEC A   P P + W   ++L G  +G  G         +    +LD G
Sbjct: 27  NVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEG 86

Query: 270 -NLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTG 327
            +L    +    SG+Y C A N+ GT  R                ++   VL  PS L  
Sbjct: 87  QSLHFPRIQEGDSGLYSCRAENQAGTAQR----------------DFHLLVLTPPSVL-- 128

Query: 328 AWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRL 387
                G+ A  + LGL                          G+     C   GVP  ++
Sbjct: 129 -----GAGAAQEVLGLA-------------------------GADVELQCWTSGVPTPQV 158

Query: 388 VWLKNGKVLSPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
            W K+ + + PG  ++++  +   L + G  V DE  YQCVA +  G      +L V   
Sbjct: 159 EWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAP 218

Query: 447 P 447
           P
Sbjct: 219 P 219


>gi|4506569 roundabout 1 isoform a [Homo sapiens]
          Length = 1651

 Score =  139 bits (351), Expect = 6e-33
 Identities = 142/506 (28%), Positives = 207/506 (40%), Gaps = 91/506 (17%)

Query: 22  VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
           V+   D +     P  L C+ EG P  +I W +    +  +     S   L+P GSL  L
Sbjct: 71  VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 130

Query: 76  AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL-SRFHQHPESIEVERGGVACF 134
             +  R+S P     Y CVA+N  G  VS  A +++A L   F Q+P  + V  G  A  
Sbjct: 131 RIVHGRKSRPDEG-VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVM 189

Query: 135 QCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           +C   +G PEP+ISW+ +G+ L+  + R+T+   G L IT   ++D G Y CV  N+   
Sbjct: 190 ECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGE 248

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
           R S+ A+LT+       L+ P  +  P NL +TV  +A  +C A   P P V W + DG 
Sbjct: 249 RESEVAELTV-------LERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 301

Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGP 312
                     +I D   L I  V+    G Y C A N  G   +  A   L VQ EP  P
Sbjct: 302 LPKSR----YEIRDDHTLKIRKVTAGDMGSYTCVAENMVG---KAEASATLTVQ-EP--P 351

Query: 313 NWV----------GRVLEHPSSLTG----AWIWR----------------GSRAGGKRLG 342
           ++V          GR +      TG    A  WR                 SR    + G
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411

Query: 343 -------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPGSS 372
                              L    S++  A L           P   Q P + +     +
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471

Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
            + +CVA G P   ++W K+G ++S  ++      N  L +    + D   Y C+A   +
Sbjct: 472 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 531

Query: 433 GSNQASARLVVT--GGP-EPPRPQGP 455
           G    SA + V   G P +PPRP  P
Sbjct: 532 GEATWSAYIEVQEFGVPVQPPRPTDP 557



 Score =  100 bits (249), Expect = 4e-21
 Identities = 97/347 (27%), Positives = 139/347 (40%), Gaps = 76/347 (21%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
           R  +HP  + V +G  A   C  +G P P+I W   G  + T      +HR+ LLPSG L
Sbjct: 69  RIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGSL 127

Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
               +     S+ D G Y CVA N      S +A L +++         +    P ++ +
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI------LRDDFRQNPSDVMV 181

Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
            V + AV+EC     HP P +SW + DG  +  +  ++   +  G LMI+      +G Y
Sbjct: 182 AVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERI--TIRGGKLMITYTRKSDAGKY 238

Query: 285 VCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLT 344
           VC                        G N VG      + LT                  
Sbjct: 239 VCV-----------------------GTNMVGERESEVAELT------------------ 257

Query: 345 APSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK-NGKVLSPGNNIR 403
                    + P FV+ P +L+     SA F C A+G P   + W K +G++      IR
Sbjct: 258 -------VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 310

Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
             H   TL +  V+  D   Y CVAEN  G  +ASA L V    EPP
Sbjct: 311 DDH---TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV---QEPP 351



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 81/309 (26%), Positives = 129/309 (41%), Gaps = 24/309 (7%)

Query: 20  AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
           +FV+   +     +      C+  G+P  ++ W++D   L  +S   +  D +L +    
Sbjct: 263 SFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-KSRYEIRDDHTLKI---- 317

Query: 80  SRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQ 139
            R+        Y CVA+N  G+     A + +     F   P    V  G    FQC   
Sbjct: 318 -RKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEAT 375

Query: 140 GVPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAS 192
           G P+P+I W   G+           ++ R ++  +G L IT+V ++D+G Y C   NVA 
Sbjct: 376 GNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAG 435

Query: 193 TRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDG 252
           +  ++       V   R    P I  GP N T+ V  T VL C+AT  P P + W R DG
Sbjct: 436 SIITKAYLEVTDVIADR--PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW-RKDG 492

Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQ------GVLLVQ 306
             +  +  ++   L+ G L I    +  +G Y C A+ P      +A       GV +  
Sbjct: 493 VLVSTQDSRIKQ-LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 551

Query: 307 GEPQGPNWV 315
             P  PN +
Sbjct: 552 PRPTDPNLI 560



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 30/100 (30%), Positives = 42/100 (42%), Gaps = 12/100 (12%)

Query: 356 PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL-----SPGNNIRLTHNNST 410
           P  V+ P  L    G  A   C A+G P   + W K G+ +      P ++  L  + S 
Sbjct: 68  PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127

Query: 411 LMLAGV----SVEDEAIYQCVAENSTG---SNQASARLVV 443
             L  V    S  DE +Y CVA N  G   S+ AS  + +
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 167


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score =  136 bits (343), Expect = 5e-32
 Identities = 164/616 (26%), Positives = 229/616 (37%), Gaps = 139/616 (22%)

Query: 2   GLLLLLLPGWGCAA-----GSELA-------FVQELGDTVAVWEHPLVLPCQVEGEPPVS 49
           GLL++ +  WG        GS L         V+   D +     P  L C+ EG P  +
Sbjct: 18  GLLMMTVVFWGHQGNGQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPT 77

Query: 50  ISWQRDRLALANE-----SGVTLMPDGSLH-LAALPSRRSLPSRAHEYHCVAQNRYGRLV 103
           I W +D   +  +     S   L+P GSL  L  +  RRS P     Y CVA+N  G  V
Sbjct: 78  IEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEG-SYVCVARNYLGEAV 136

Query: 104 SRRARVQLASL-SRFHQHPESIEVERGGVACFQCL-IQGVPEPSISWEHNGTALNTANHR 161
           SR A +++A L   F Q+P  + V  G  A  +C   +G PEP+I W+ +   ++    R
Sbjct: 137 SRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEER 196

Query: 162 VTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQ 221
           ++ +  G L I++  ++D G Y CV  N+   R S  A+LT       + + P  L  P 
Sbjct: 197 IS-IRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELT-------VFERPTFLRRPI 248

Query: 222 NLTLTVHQTAVLECIATSHPWPLVSWSRLD-----GRSIGVEGIQVLDILDTGNLMISDV 276
           N  +   +     C     P P V W + D     GR          DI D   L I   
Sbjct: 249 NQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGR---------YDIKDDYTLRIKKT 299

Query: 277 SVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQ---GPN----WVGRVLEHPSSLTG- 327
                G Y+C A NR G   +  A   L V+  PQ    P       GR +  P    G 
Sbjct: 300 MSTDEGTYMCIAENRVG---KMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGN 356

Query: 328 ---AWIWR----------------GSRAGGKRLG-------------------LTAPSSM 349
              A  W+                 SR      G                   LT   S+
Sbjct: 357 PQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSI 416

Query: 350 LLPAQL-----------PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSP 398
           L  AQL           P  +Q P + +     +A+  C A G P   + WLK G    P
Sbjct: 417 LAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTF-P 475

Query: 399 GNNIRLT-HNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPAC 457
           G + R T     TL +  + + D   Y CVA +S+G    SA L VT             
Sbjct: 476 GRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTES----------- 524

Query: 458 HGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPAT 517
                       GAT   + D+          G PS P++ +     T   V  + +P T
Sbjct: 525 ------------GATISKNYDLSDL------PGPPSKPQVTDV----TKNSVTLSWQPGT 562

Query: 518 AYTIHLRAYSAEGASQ 533
             T+   AY  E  SQ
Sbjct: 563 PGTLPASAYIIEAFSQ 578


>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
           sapiens]
          Length = 1386

 Score =  136 bits (342), Expect = 7e-32
 Identities = 154/612 (25%), Positives = 227/612 (37%), Gaps = 96/612 (15%)

Query: 6   LLLPGWGCAAGSELA-------FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRD--R 56
           LL PG     GS +         V++  D +     P  LPC+ EG P  +I W ++  R
Sbjct: 44  LLPPGDPSLNGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGAR 103

Query: 57  LALANESGVT---LMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLAS 113
           +A   E       L+P G+L    +   R        Y CVA+N  G   SR A +++A 
Sbjct: 104 VATVREDPRAHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV 163

Query: 114 L-SRFHQHPESIEVERGGVACFQCLI-QGVPEPSISWEHNGTALNTANHRVTLLPSGILH 171
           L   F Q P ++ V  G  A  +C+  +G PEPS+SW  +G  L     R+T+   G L 
Sbjct: 164 LRDDFRQSPGNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIR-GGKLM 222

Query: 172 ITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA 231
           ++   ++D G Y CVA N+A  R S  A++ +       L+ P  L  P N  +      
Sbjct: 223 MSHTLKSDAGMYVCVASNMAGERESAAAEVMV-------LERPSFLRRPVNQVVLADAPV 275

Query: 232 VLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANR- 290
              C     P P + W + DG           +I    +L I  VS +  G Y C A   
Sbjct: 276 TFLCEVKGDPPPRLRWRKEDGELPTGR----YEIRSDHSLWIGHVSAEDEGTYTCVAENS 331

Query: 291 ----------------------------PGTHV----------------RRTAQGVLLVQ 306
                                       PG  V                ++    VLL  
Sbjct: 332 VGRAEASGSLSVHVPPQLVTQPQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFP 391

Query: 307 GEPQGPNWVGRVLEHP-SSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQL---------- 355
            +   P   GR    P   L    + RG         ++   S+L  A L          
Sbjct: 392 SQSLQPT--GRFSVSPRGQLNITAVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGL 449

Query: 356 -PEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
            P  +Q P + +   GSS    C   G P+  + W K+G+ L   +    T  N TL +A
Sbjct: 450 PPVILQGPANQTLVLGSSVWLPCRVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIA 509

Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVVTG----GPEPPR-----PQGPACHGSLYFCH 465
            V   D   Y CVA++STG    S  L +       P+PP      P  P+         
Sbjct: 510 NVQEMDMGFYSCVAKSSTGEATWSGWLKMREDWGVSPDPPTEPSSPPGAPSQPVVTEITK 569

Query: 466 SSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGT--SEHVFSNLEPATAYTIHL 523
           +S+     P+ +       ++     P+       ++ G     H  S L+P T Y   +
Sbjct: 570 NSITLTWKPNPQTGAAVTSYVIEAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLV 629

Query: 524 RAYSAEGASQDS 535
           RA  A G S+ S
Sbjct: 630 RAVGAWGLSEPS 641



 Score =  114 bits (286), Expect = 2e-25
 Identities = 125/451 (27%), Positives = 175/451 (38%), Gaps = 88/451 (19%)

Query: 113 SLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTAN-----HRVTLLPS 167
           ++ R  + P  + V RG  A   C  +G P P+I W  NG  + T       HR+ LLPS
Sbjct: 62  AMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRAHRL-LLPS 120

Query: 168 GILHITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQN 222
           G L    +     ++ D G Y CVA N      S++A L ++V         +    P N
Sbjct: 121 GALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAV------LRDDFRQSPGN 174

Query: 223 LTLTVHQTAVLECIAT-SHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHS 281
           + + V + AVLEC+    HP P VSW R DG  +  E  ++   +  G LM+S      +
Sbjct: 175 VVVAVGEPAVLECVPPRGHPEPSVSW-RKDGARLKEEEGRIT--IRGGKLMMSHTLKSDA 231

Query: 282 GVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRL 341
           G+YVC A+         A  V+              VLE PS L                
Sbjct: 232 GMYVCVASNMAGERESAAAEVM--------------VLERPSFLR--------------- 262

Query: 342 GLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN- 400
               P + ++ A  P                  F C  +G P  RL W K    L  G  
Sbjct: 263 ---RPVNQVVLADAP----------------VTFLCEVKGDPPPRLRWRKEDGELPTGRY 303

Query: 401 NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE---PPRPQGPAC 457
            IR  H+   L +  VS EDE  Y CVAENS G  +AS  L V   P+    P+ Q  A 
Sbjct: 304 EIRSDHS---LWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQPQDQMAAP 360

Query: 458 HGSLYFCHSSVLGATPPS-------SRDIIGYVLHLRPVG----EPSGPELQEAISKGTS 506
             S+ F      G  PP+       S+ ++     L+P G     P G     A+ +G +
Sbjct: 361 GESVAF-QCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITAVQRGDA 419

Query: 507 EHVFSNLEPATAYTIHLRAYSAEGASQDSAP 537
            +            +       +GAS D  P
Sbjct: 420 GYYVCQAVSVAGSILAKALLEIKGASLDGLP 450


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score =  134 bits (338), Expect = 2e-31
 Identities = 156/584 (26%), Positives = 218/584 (37%), Gaps = 127/584 (21%)

Query: 22  VQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE-----SGVTLMPDGSLH-L 75
           V+   D +     P  L C+ EG P  +I W +D   +  +     S   L+P GSL  L
Sbjct: 34  VEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFL 93

Query: 76  AALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL-SRFHQHPESIEVERGGVACF 134
             +  RRS P     Y CVA+N  G  VSR A +++A L   F Q+P  + V  G  A  
Sbjct: 94  RIVHGRRSKPDEG-SYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAIL 152

Query: 135 QCL-IQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
           +C   +G PEP+I W+ +   ++    R++ +  G L I++  ++D G Y CV  N+   
Sbjct: 153 ECQPPRGHPEPTIYWKKDKVRIDDKEERIS-IRGGKLMISNTRKSDAGMYTCVGTNMVGE 211

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLD-- 251
           R S  A+LT       + + P  L  P N  +   +     C     P P V W + D  
Sbjct: 212 RDSDPAELT-------VFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDAD 264

Query: 252 ---GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQG 307
              GR          DI D   L I        G Y+C A NR G   +  A   L V+ 
Sbjct: 265 LPRGR---------YDIKDDYTLRIKKTMSTDEGTYMCIAENRVG---KMEASATLTVRA 312

Query: 308 EPQ---GPN----WVGRVLEHPSSLTG----AWIWR----------------GSRAGGKR 340
            PQ    P       GR +  P    G    A  W+                 SR     
Sbjct: 313 PPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSP 372

Query: 341 LG-------------------LTAPSSMLLPAQL-----------PEFVQWPQSLSKPPG 370
            G                   LT   S+L  AQL           P  +Q P + +    
Sbjct: 373 TGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVD 432

Query: 371 SSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLT-HNNSTLMLAGVSVEDEAIYQCVAE 429
            +A+  C A G P   + WLK G    PG + R T     TL +  + + D   Y CVA 
Sbjct: 433 GTALLKCKATGDPLPVISWLKEGFTF-PGRDPRATIQEQGTLQIKNLRISDTGTYTCVAT 491

Query: 430 NSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPV 489
           +S+G    SA L VT                         GAT   + D+          
Sbjct: 492 SSSGETSWSAVLDVTES-----------------------GATISKNYDLSDL------P 522

Query: 490 GEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQ 533
           G PS P++ +     T   V  + +P T  T+   AY  E  SQ
Sbjct: 523 GPPSKPQVTDV----TKNSVTLSWQPGTPGTLPASAYIIEAFSQ 562



 Score =  107 bits (266), Expect = 5e-23
 Identities = 77/275 (28%), Positives = 135/275 (49%), Gaps = 18/275 (6%)

Query: 21  FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
           F++   + V + E  +   CQV+G+P  ++ W++D   L       +  D +L +     
Sbjct: 227 FLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPR-GRYDIKDDYTLRI----- 280

Query: 81  RRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQG 140
           ++++ +    Y C+A+NR G++ +  A + + +  +F   P    V +G    F C  +G
Sbjct: 281 KKTMSTDEGTYMCIAENRVGKMEAS-ATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKG 339

Query: 141 VPEPSISWEHNGTAL-------NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
            P+P++ W+  G+            N R ++ P+G L IT++ ++D G Y C A  VA +
Sbjct: 340 NPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGS 399

Query: 194 RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
             ++ AQL ++   L     P IL GP N TL V  TA+L+C AT  P P++SW +    
Sbjct: 400 ILAK-AQLEVT-DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFT 457

Query: 254 SIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA 288
             G +      I + G L I ++ +  +G Y C A
Sbjct: 458 FPGRD--PRATIQEQGTLQIKNLRISDTGTYTCVA 490



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 102/409 (24%), Positives = 158/409 (38%), Gaps = 83/409 (20%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNT-----ANHRVTLLPSGIL 170
           R  +HP  + V +G      C  +G P P+I W  +G  + T      +HR+ LLPSG L
Sbjct: 32  RIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRM-LLPSGSL 90

Query: 171 HITSV-----SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTL 225
               +     S+ D G+Y CVA N      S++A L ++      L   +    P ++ +
Sbjct: 91  FFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVA------LLRDDFRQNPTDVVV 144

Query: 226 TVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVY 284
              + A+LEC     HP P + W +     + ++  +    +  G LMIS+     +G+Y
Sbjct: 145 AAGEPAILECQPPRGHPEPTIYWKK---DKVRIDDKEERISIRGGKLMISNTRKSDAGMY 201

Query: 285 VCAA-----------------NRPGTHVRRTAQGVLL----------VQGEPQ------- 310
            C                    RP T +RR    V+L          VQG+PQ       
Sbjct: 202 TCVGTNMVGERDSDPAELTVFERP-TFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260

Query: 311 ------------GPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEF 358
                         ++  R+ +  S+  G ++         R+G    S+ L     P+F
Sbjct: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMC----IAENRVGKMEASATLTVRAPPQF 316

Query: 359 VQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNG--KVLSPG-----NNIRLTHNNSTL 411
           V  P+      G +  F C  +G P+  + W K G   +L P      N+         L
Sbjct: 317 VVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDL 376

Query: 412 MLAGVSVEDEAIYQCVAENSTGSNQASARL----VVTGGPEPPRPQGPA 456
            +  +   D   Y C A    GS  A A+L    V+T  P P   QGPA
Sbjct: 377 TITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPA 425



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 75/305 (24%), Positives = 115/305 (37%), Gaps = 61/305 (20%)

Query: 201 LTLSVGPLRLLQE---PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV 257
           L + V   RL QE   P I+  P ++ ++  +   L C A   P P + W + DG  +  
Sbjct: 15  LYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYK-DGERVET 73

Query: 258 EGIQVLD---ILDTGNLMISDV-----SVQHSGVYVCAA-NRPGTHVRRTAQ-------- 300
           +         +L +G+L    +     S    G YVC A N  G  V R A         
Sbjct: 74  DKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRD 133

Query: 301 -------GVLLVQGEP-----QGPN--------W------VGRVLEHPSSLTGAWIWRGS 334
                   V++  GEP     Q P         W      +    E  S   G  +   +
Sbjct: 134 DFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNT 193

Query: 335 RAGGKRLGLTAPSSML-----LPAQL-----PEFVQWPQSLSKPPGSSAIFTCVAQGVPE 384
           R     +     ++M+      PA+L     P F++ P +       +  F C  QG P+
Sbjct: 194 RKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQ 253

Query: 385 SRLVWLKNGKVLSPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
             + W K+   L  G  +I+   ++ TL +      DE  Y C+AEN  G  +ASA L V
Sbjct: 254 PTVRWKKDDADLPRGRYDIK---DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310

Query: 444 TGGPE 448
              P+
Sbjct: 311 RAPPQ 315


>gi|109150416 peroxidasin [Homo sapiens]
          Length = 1479

 Score =  127 bits (319), Expect = 3e-29
 Identities = 96/329 (29%), Positives = 136/329 (41%), Gaps = 57/329 (17%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALN-TANHRVTLLPSGILHITS 174
           R    P+  +V  G    F C  +G P+P I W  N   L+   + R+ LL  G L I +
Sbjct: 247 RITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQN 306

Query: 175 VSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLE 234
             +TD G Y+C+A NVA    +Q+  L     P R    P  +  PQN  + V ++  LE
Sbjct: 307 TQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPAR----PTFVIQPQNTEVLVGESVTLE 362

Query: 235 CIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTH 294
           C AT HP P +SW+R D   + V+    ++I  +G L I +V    SG Y C+A      
Sbjct: 363 CSATGHPPPRISWTRGDRTPLPVD--PRVNITPSGGLYIQNVVQGDSGEYACSATNNIDS 420

Query: 295 VRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQ 354
           V  TA   ++VQ  PQ                                            
Sbjct: 421 VHATA--FIIVQALPQ-------------------------------------------- 434

Query: 355 LPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLA 414
              F   PQ      G +  F C A+G P   + W K G  LS      L  ++ TL ++
Sbjct: 435 ---FTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRR-HLVLSSGTLRIS 490

Query: 415 GVSVEDEAIYQCVAENSTGSNQASARLVV 443
           GV++ D+  Y+C A N  GS +  A L V
Sbjct: 491 GVALHDQGQYECQAVNIIGSQKVVAHLTV 519



 Score =  109 bits (273), Expect = 7e-24
 Identities = 99/409 (24%), Positives = 168/409 (41%), Gaps = 69/409 (16%)

Query: 40  CQVEGEPPVSISWQRDR--LALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
           C+ EG P   I W R+   L++  +S + L+ DG+L +     + +  +    Y C+A+N
Sbjct: 267 CRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMI-----QNTQETDQGIYQCMAKN 321

Query: 98  RYGRLVSRRARVQ-LASLSR--FHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTA 154
             G + ++   ++   S +R  F   P++ EV  G     +C   G P P ISW      
Sbjct: 322 VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRT 381

Query: 155 LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
               + RV + PSG L+I +V Q D G Y C A N   + H+    +  ++        P
Sbjct: 382 PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQAL--------P 433

Query: 215 EILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMIS 274
           +    PQ+  +   QT   +C A  +P P+++W++  G  + V+   +  +L +G L IS
Sbjct: 434 QFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK-GGSQLSVDRRHL--VLSSGTLRIS 490

Query: 275 DVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGS 334
            V++   G Y C             Q V ++  +        +V+ H +           
Sbjct: 491 GVALHDQGQYEC-------------QAVNIIGSQ--------KVVAHLT----------- 518

Query: 335 RAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGK 394
                          + P   P F   P   +   G++    C +QG PE  + W K+G 
Sbjct: 519 ---------------VQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGV 563

Query: 395 VLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            ++      ++     L +  V   D   Y+CVA N+ GS   S  L V
Sbjct: 564 QVTESGKFHIS-PEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611



 Score = 99.4 bits (246), Expect = 9e-21
 Identities = 82/269 (30%), Positives = 118/269 (43%), Gaps = 17/269 (6%)

Query: 21  FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANESGVTLMPDGSLHLAALP 79
           FV +  +T  +    + L C   G PP  ISW R DR  L  +  V + P G L++    
Sbjct: 344 FVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYI---- 399

Query: 80  SRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQ 139
            +  +   + EY C A N     V   A + + +L +F   P+   V  G    FQC  +
Sbjct: 400 -QNVVQGDSGEYACSATNNIDS-VHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAK 457

Query: 140 GVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
           G P P I+W   G+ L + + R  +L SG L I+ V+  D G Y C A N+     SQ  
Sbjct: 458 GNPPPVIAWTKGGSQL-SVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG---SQKV 513

Query: 200 QLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEG 259
              L+V P      P   S P + T+ V     L C +   P P ++W++ DG  +   G
Sbjct: 514 VAHLTVQP---RVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNK-DGVQVTESG 569

Query: 260 IQVLDILDTGNLMISDVSVQHSGVYVCAA 288
                I   G L I+DV    +G Y C A
Sbjct: 570 --KFHISPEGFLTINDVGPADAGRYECVA 596



 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 51/180 (28%), Positives = 75/180 (41%), Gaps = 10/180 (5%)

Query: 27  DTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPS 86
           D V +    +   C+ +G PP  I+W +    L+ +    ++  G+L ++ +        
Sbjct: 441 DRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQ--- 497

Query: 87  RAHEYHCVAQNRYG-RLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPS 145
              +Y C A N  G + V     VQ      F   P    VE G      C  QG PEP+
Sbjct: 498 --GQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPA 555

Query: 146 ISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSV 205
           I+W  +G  + T + +  + P G L I  V   D G Y CVA N   T  S    + LSV
Sbjct: 556 ITWNKDGVQV-TESGKFHISPEGFLTINDVGPADAGRYECVARN---TIGSASVSMVLSV 611



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 72/315 (22%), Positives = 114/315 (36%), Gaps = 72/315 (22%)

Query: 159 NHRVT-LLPSGILHITSVSQT--DMGTYRC---VAW------NVASTRHSQDAQL----- 201
           N+R+T L+P    H+ S+ +   D  T  C   + W        A + ++Q A +     
Sbjct: 167 NNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPR 226

Query: 202 ------TLSVGPLRL-LQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRS 254
                   ++ P  L  + P I S PQ+  +T   T    C A  +P P + W R +   
Sbjct: 227 RIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLR-NNNE 285

Query: 255 IGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
           + ++    L++LD G LMI +      G+Y C A      V+ T +  L   G P  P  
Sbjct: 286 LSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVK-TQEVTLRYFGSPARPT- 343

Query: 315 VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
                                                      FV  PQ+     G S  
Sbjct: 344 -------------------------------------------FVIQPQNTEVLVGESVT 360

Query: 375 FTCVAQGVPESRLVWLKNGKVLSPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
             C A G P  R+ W +  +   P +  + +T +   L +  V   D   Y C A N+  
Sbjct: 361 LECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATNNID 419

Query: 434 SNQASARLVVTGGPE 448
           S  A+A ++V   P+
Sbjct: 420 SVHATAFIIVQALPQ 434



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 6/80 (7%)

Query: 38  LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
           LPC  +GEP  +I+W +D + +       + P+G L +  +      P+ A  Y CVA+N
Sbjct: 544 LPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVG-----PADAGRYECVARN 598

Query: 98  RYGRL-VSRRARVQLASLSR 116
             G   VS    V +  +SR
Sbjct: 599 TIGSASVSMVLSVNVPDVSR 618


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score =  122 bits (306), Expect = 1e-27
 Identities = 116/445 (26%), Positives = 176/445 (39%), Gaps = 73/445 (16%)

Query: 19   LAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAAL 78
            +A   E  D   +    + L C+ +  PP  I+W R+   L     V ++  G      L
Sbjct: 3622 IAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRY----L 3677

Query: 79   PSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLI 138
                +       Y CVA N  G+  +R   + +         P+S+ +        +C+ 
Sbjct: 3678 QINNADLGDTANYTCVASNIAGK-TTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIA 3736

Query: 139  QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST-RHSQ 197
            +GVP P I+W  +G  L   + R ++L +G LHI S   TD G Y C+A N A T R   
Sbjct: 3737 EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRI 3796

Query: 198  DAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV 257
            D Q+ +          P I  GP N+T+ V+    L C AT  P P ++W R +G  + V
Sbjct: 3797 DLQVHV---------PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINW-RKNGHLLNV 3846

Query: 258  EGIQ-VLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG 316
            +  Q    +L +G+L+I   SV  +  Y C         +RT                V 
Sbjct: 3847 DQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRT----------------VD 3890

Query: 317  RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFT 376
              ++ P S+                    P+  L+    P                A+ T
Sbjct: 3891 LTVQVPPSIA-----------------DEPTDFLVTKHAP----------------AVIT 3917

Query: 377  CVAQGVPESRLVWLKNG-KVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
            C A GVP   + W KNG ++L  G+  R+  + +  +LA   +     Y CVA N+ GS 
Sbjct: 3918 CTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILA-TQLNHAGRYTCVARNAAGSA 3976

Query: 436  QASARLVVTGGPEPP--RPQGPACH 458
                 L V    EPP  +PQ    H
Sbjct: 3977 HRHVTLHV---HEPPVIQPQPSELH 3998



 Score =  119 bits (299), Expect = 7e-27
 Identities = 124/480 (25%), Positives = 192/480 (40%), Gaps = 77/480 (16%)

Query: 20   AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANES-GVTLMPDGSLHLAAL 78
            +   E  D +     P V+ C   G P  SI W ++ + L     G  ++  G++ + A 
Sbjct: 3898 SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILAT 3957

Query: 79   PSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLI 138
                   + A  Y CVA+N  G    R   + +         P  + V         C  
Sbjct: 3958 QL-----NHAGRYTCVARNAAGS-AHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEA 4011

Query: 139  QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
             G P P I+W+  G  +NT+     +LPSG L I+   + D GTY CVA N A T     
Sbjct: 4012 TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGT----- 4066

Query: 199  AQLTLSVGPLRL-LQEPEILSGP-QNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIG 256
                 ++G ++L +Q P ++S   +   + V +   L C A   P P ++W + DGR+I 
Sbjct: 4067 -----ALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHK-DGRAI- 4119

Query: 257  VEGIQVLDILDTGNLMISDVSVQHSGVYVC-AANRPGTH--------------------- 294
            VE I+   +L +G+L I+ V    +G Y C AAN  G+                      
Sbjct: 4120 VESIR-QRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHY 4178

Query: 295  -VRRTAQGVL--LVQGEP-QGPNW----------VGRVLEHPSSL----------TGAWI 330
             V   +Q +L  +  G P    NW          +G+    P             +G + 
Sbjct: 4179 TVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYT 4238

Query: 331  WRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWL 390
               + A G+       +  L    LP F + P  +S   G     +C A G+P  +L W 
Sbjct: 4239 CVANNAAGE----DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWT 4294

Query: 391  KNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
             N  ++    +    + +S L++  VS ED   Y C AENS G  +A   + V    EPP
Sbjct: 4295 FNNNIIPA--HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYV---KEPP 4349



 Score =  116 bits (291), Expect = 6e-26
 Identities = 113/421 (26%), Positives = 172/421 (40%), Gaps = 74/421 (17%)

Query: 35   PLVLPCQVEGEPPVSISW-QRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHC 93
            P+ LPC+  G P  S+ W ++  L   + +  +   DGSL++ +     S      EY C
Sbjct: 997  PVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEES-----GEYVC 1051

Query: 94   VAQNRYGRLVSR-------RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSI 146
             A N  G    +       R RV           P  I V  G      C ++ +P P I
Sbjct: 1052 TATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII 1111

Query: 147  SWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVG 206
            +W      ++  + R T LPSG + IT    +D G Y CVA N+A    +Q  +L + V 
Sbjct: 1112 TWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAG-NVTQAVKLNVHV- 1169

Query: 207  PLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDIL 266
                   P+I  GP++L + V Q   + C A   P P+++WS+  G ++ V+G   +   
Sbjct: 1170 ------PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSK-GGSTMLVDGEHHVSNP 1222

Query: 267  DTGNLMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSL 325
            D G L I   +   +G+Y C A N  GT      +  L VQ  P   +     LE P + 
Sbjct: 1223 D-GTLSIDQATPSDAGIYTCVATNIAGTD---ETEITLHVQEPPTVED-----LEPPYNT 1273

Query: 326  TGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPES 385
            T        R   +R+                                 F C A+G P+ 
Sbjct: 1274 TFQ-----ERVANQRIE--------------------------------FPCPAKGTPKP 1296

Query: 386  RLVWLKNGKVLS---PGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLV 442
             + WL NG+ L+   PG  I +  + + L++A V+  D   Y CVA N  G+ +    L 
Sbjct: 1297 TIKWLHNGRELTGREPG--ISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLK 1354

Query: 443  V 443
            V
Sbjct: 1355 V 1355



 Score =  115 bits (288), Expect = 1e-25
 Identities = 108/460 (23%), Positives = 181/460 (39%), Gaps = 77/460 (16%)

Query: 38   LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
            L C+V+G PP +++W +D   L    GV ++ +G +    L  +    S    Y CVA N
Sbjct: 2312 LECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHI----LQLKNIHVSDTGRYVCVAVN 2367

Query: 98   RYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTA 154
              G +  ++  + +    S+   H+ PE+I V         C   G+P PSI+W  +G  
Sbjct: 2368 VAG-MTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWP 2426

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
            ++ +N    L    +L +   +  D G Y CV  N A             +  L +L  P
Sbjct: 2427 VSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERK--------IFGLSVLVPP 2478

Query: 215  EILSGP--QNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGN-L 271
             I+     +++ +   Q+  L C  T +P P ++W + DG+ +  +  +   I+  G  L
Sbjct: 2479 HIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK-DGQPLQED--EAHHIISGGRFL 2535

Query: 272  MISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ------GEPQGPNWVGRVLEHPSSL 325
             I++V V H+G Y C A+ P  H  R+    + V       G    P  V  +L  P+SL
Sbjct: 2536 QITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSL 2595

Query: 326  ----------TGAWIWRGSRAGGKRLGLTAPSS---MLLPAQ------------------ 354
                      T  W   G+     R     P      +L AQ                  
Sbjct: 2596 VCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEM 2655

Query: 355  ---------LPEFVQ----W-----PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL 396
                     +P  +     W     P+ +     ++    C A  +P + L W K+G+ L
Sbjct: 2656 IKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPL 2715

Query: 397  SPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
               +++ +  N  TL +    + D   Y CVA N  G ++
Sbjct: 2716 KSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDE 2755



 Score =  115 bits (288), Expect = 1e-25
 Identities = 102/403 (25%), Positives = 156/403 (38%), Gaps = 67/403 (16%)

Query: 38   LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
            L C+V G PP  +SW ++   +   +   ++P G      L   R+  S   EY C+A N
Sbjct: 2984 LTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGR----TLQIIRAKVSDGGEYTCIAIN 3039

Query: 98   RYGRLVSRRARVQLASLSRFHQHPES---IEVERGGVACFQCLIQGVPEPSISWEHNGTA 154
            + G    + +       S      ES   + V  G     +C    VP P I+W  NG  
Sbjct: 3040 QAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRM 3099

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
            +  + H   L    +LHI     +D G Y C A NVA  R  ++  L + V        P
Sbjct: 3100 ITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAG-RDDKNFHLNVYV--------P 3150

Query: 215  EILSGPQN--LTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM 272
              + GP+   +  T+     L C AT  P P ++W +   R    + ++V  +     L 
Sbjct: 3151 PSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQ 3210

Query: 273  ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWR 332
            I+      SG Y C A+               ++G+ Q   ++   ++ P S+ GA I  
Sbjct: 3211 IARSQHSDSGNYTCIASN--------------MEGKAQKYYFLS--IQVPPSVAGAEI-- 3252

Query: 333  GSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKN 392
                                         P  +S   G +    C A G+P   + WLK+
Sbjct: 3253 -----------------------------PSDVSVLLGENVELVCNANGIPTPLIQWLKD 3283

Query: 393  GKVLSPG--NNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
            GK ++ G    IR++ N STL + G    D   Y CVA N  G
Sbjct: 3284 GKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAG 3326



 Score =  113 bits (283), Expect = 5e-25
 Identities = 124/477 (25%), Positives = 189/477 (39%), Gaps = 85/477 (17%)

Query: 37   VLPCQVEGEPPVSISWQRDRLALA-NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            VL C  EG P   I+W++D   LA N +  +++ +G LH+ +     +  +    Y C+A
Sbjct: 3731 VLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQS-----AHVTDTGRYLCMA 3785

Query: 96   QNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTAL 155
             N  G    RR  +Q+         P ++ V         C   G+P+PSI+W  NG  L
Sbjct: 3786 TNAAGT-DRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLL 3844

Query: 156  NTANHRVT--LLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQE 213
            N   ++ +  LL SG L I S S  D  TY C   N A     +   LT+ V        
Sbjct: 3845 NVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGD-DKRTVDLTVQV-------P 3896

Query: 214  PEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLD------ILD 267
            P I   P +  +T H  AV+ C A+  P+P + W++         GI++L       IL 
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTK--------NGIRLLPRGDGYRILS 3948

Query: 268  TGNLMISDVSVQHSGVYVCAA-NRPGT---HVRRTAQGVLLVQGEPQGPNWV-GRVLEHP 322
            +G + I    + H+G Y C A N  G+   HV        ++Q +P   + +    +  P
Sbjct: 3949 SGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLP 4008

Query: 323  SSLTGA------WIWRG--------------------SRA---------------GGKRL 341
               TG       W   G                    SRA                G  L
Sbjct: 4009 CEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTAL 4068

Query: 342  GLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNN 401
            G    +  + P   P   ++  ++ KP       +C A G+P   + W K+G+ +     
Sbjct: 4069 GKIKLNVQVPPVISPHLKEYVIAVDKP----ITLSCEADGLPPPDITWHKDGRAIVESIR 4124

Query: 402  IRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACH 458
             R+  + S L +A V   D   Y C+A N  GS+  S +L V     PPR +    H
Sbjct: 4125 QRVLSSGS-LQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV---HVPPRIRSTEGH 4177



 Score =  108 bits (271), Expect = 1e-23
 Identities = 143/602 (23%), Positives = 228/602 (37%), Gaps = 90/602 (14%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGV-TLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
            + LPC+V+  PP  I+W ++   ++  S   T +P GS+ +       +  S +  Y CV
Sbjct: 1097 VTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKIT-----ETRTSDSGMYLCV 1151

Query: 95   AQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTA 154
            A N  G  V++  ++ +    +  + P+ ++V+ G      C  QG P P I+W   G+ 
Sbjct: 1152 ATNIAGN-VTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGST 1210

Query: 155  LNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEP 214
            +          P G L I   + +D G Y CVA N+A T    + ++TL V      QEP
Sbjct: 1211 MLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGT---DETEITLHV------QEP 1261

Query: 215  ---EILSGPQNLTL---TVHQTAVLECIATSHPWPLVSW----SRLDGRSIGVEGIQVLD 264
               E L  P N T      +Q     C A   P P + W      L GR  G+       
Sbjct: 1262 PTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGIS------ 1315

Query: 265  ILDTGNLM-ISDVSVQHSGVYVCAA-NRPGTHVRR-----------------TAQGVLL- 304
            IL+ G L+ I+ V+   +G Y+C A N  GT  R+                 T   VLL 
Sbjct: 1316 ILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLN 1375

Query: 305  --------VQGEPQGP-NWVGRVLEHPSSLTGAWIWRGS-------------RAGGKRLG 342
                    V+G P     W    ++   S T   +  G              R   K + 
Sbjct: 1376 QLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAIN 1435

Query: 343  LTAPSS------MLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVL 396
            +   S       +L+P  +     +P  +S          C  +G P   + W K+GK L
Sbjct: 1436 IAGTSQKYFNIDVLVPPTIIG-TNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPL 1494

Query: 397  SPGN-NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGP 455
              G+ N+ L      L L      D+  YQC   N+ G      +L +     PP  +G 
Sbjct: 1495 FLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIY---IPPSIKGG 1551

Query: 456  ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEA-ISKGTSEHV-FSNL 513
                 +    +S++      +R +    +     G+P     Q   I KG   H+  + +
Sbjct: 1552 NVTTDISVLINSLI-KLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQV 1610

Query: 514  EPATAYTIHLRAYSAEGASQDSAPIFASTM-GSNLGEALNLPVPLKACLS-QCDLAPEPA 571
              +  YT H+   +          ++   M   NL   LN  V +   L+ +C  A  P+
Sbjct: 1611 SDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPS 1670

Query: 572  AL 573
             +
Sbjct: 1671 PI 1672



 Score =  108 bits (269), Expect = 2e-23
 Identities = 117/461 (25%), Positives = 182/461 (39%), Gaps = 77/461 (16%)

Query: 38   LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
            + C+  G PP  I+W ++ L L   S + L+  G +    +   R+  S    Y CVA N
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQV----IRIVRAQVSDVAVYTCVASN 3417

Query: 98   RYGRLVSRRARVQLASLSRFHQH--PESIEVERGGVACFQCLIQGVPEPSISWEHNGTAL 155
            R G + ++   +Q+ +          E I V +G      C+  G P PS++W  +G  L
Sbjct: 3418 RAG-VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPL 3476

Query: 156  NTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAS--TRHSQDAQLTLSVGPLRLLQE 213
                H        +L +      D G Y C+A N A   ++H            L++L+ 
Sbjct: 3477 GLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHF----------ILKVLEP 3526

Query: 214  PEILSGPQN--LTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
            P I    ++  +++ V+    L CIA+  P P ++W + DGR +  +  QV  +     L
Sbjct: 3527 PHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMK-DGRPL-PQTDQVQTLGGGEVL 3584

Query: 272  MISDVSVQHSGVYVCAANRPG----------THVRRTAQGVLLVQGEPQGPNWVGR---V 318
             IS   V+ +G Y C A+ P            HV     G      EP+    +      
Sbjct: 3585 RISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGT----DEPRDITVLRNRQVT 3640

Query: 319  LEHPSSLTG----AWIWRGSR----------AGGKRL---------------------GL 343
            LE  S         W+  G R          +GG+ L                     G 
Sbjct: 3641 LECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGK 3700

Query: 344  TAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIR 403
            T    +L     P     PQSL      S +  C+A+GVP  R+ W K+G VL+ GN+ R
Sbjct: 3701 TTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA-GNHAR 3759

Query: 404  LT-HNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
             +   N  L +    V D   Y C+A N+ G+++    L V
Sbjct: 3760 YSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQV 3800



 Score =  106 bits (264), Expect = 8e-23
 Identities = 110/454 (24%), Positives = 172/454 (37%), Gaps = 65/454 (14%)

Query: 25   LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
            L + V   + P+ L C+ +G PP  I+W +D  A+       ++  GSL +A +      
Sbjct: 4085 LKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQ----- 4139

Query: 85   PSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEP 144
            P  A  Y C+A N  G   S   ++ +    R         V     A   C+  G+P P
Sbjct: 4140 PGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTP 4198

Query: 145  SISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
            +I+W+ +   L     + T  P G L + +V   D G Y CVA N A    +    LT+ 
Sbjct: 4199 AINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAG-EDTHTVSLTVH 4257

Query: 205  VGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLD 264
            V        P     P +++L   +   L C AT  P P ++W+  +     +       
Sbjct: 4258 V-------LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN----IIPAHFDS 4306

Query: 265  ILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEP-----QGPNWVGRV- 318
            +     L+I  VS + SG YVC A      V+  A G + V+  P        NW+  + 
Sbjct: 4307 VNGHSELVIERVSKEDSGTYVCTAENSVGFVK--AIGFVYVKEPPVFKGDYPSNWIEPLG 4364

Query: 319  --------LEHPSSLTGAWIWRG---------SRAGGKRLGL------------------ 343
                    ++   + T  W  +G          + G   L +                  
Sbjct: 4365 GNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNE 4424

Query: 344  --TAPSSMLLPAQLPEFVQW-PQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGN 400
                  SM L  Q P  +   P       G   I  C A G P+  + W + G  +S  +
Sbjct: 4425 AGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDD 4484

Query: 401  NIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
             + +  NNS L +A    ED + ++CVA N  GS
Sbjct: 4485 RVNVLSNNS-LYIADAQKEDTSEFECVARNLMGS 4517



 Score =  102 bits (255), Expect = 9e-22
 Identities = 121/503 (24%), Positives = 187/503 (37%), Gaps = 90/503 (17%)

Query: 16   GSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQR-DRLALANE----SGVTLMPD 70
            GS   F+QE  D        + LPC V+G P  +I W+R D + + +     S ++ +  
Sbjct: 790  GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRT 849

Query: 71   GSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASL--SRFHQHPESIEVER 128
            G+L +  L       S    Y C A+N++G++ S    V +  L        P    V  
Sbjct: 850  GALFILNL-----WASDKGTYICEAENQFGKIQS-ETTVTVTGLVAPLIGISPSVANVIE 903

Query: 129  GGVACFQC-LIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVA 187
            G      C L+ G P P   W  N +A+   N  +T+   G LHI  V   D G Y CVA
Sbjct: 904  GQQLTLPCTLLAGNPIPERRWIKN-SAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVA 962

Query: 188  WNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSW 247
             NVA T +   + +   +        P I  G Q L+        L C A+ +P P V W
Sbjct: 963  SNVAGTNNKTTSVVVHVL--------PTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIW 1014

Query: 248  SRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ- 306
            S+  G  I     +     D G+L +     + SG YVC A     + +R  Q  + V+ 
Sbjct: 1015 SK-KGELISTSSAKFSAGAD-GSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRP 1072

Query: 307  ---GEPQG--------------------------------------------------PN 313
               G+ +G                                                  P+
Sbjct: 1073 RVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPS 1132

Query: 314  WVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQ-WPQSLSKPPGSS 372
               ++ E  +S +G ++   +   G         ++ L   +P  +Q  P+ L    G  
Sbjct: 1133 GSMKITETRTSDSGMYLCVATNIAG-----NVTQAVKLNVHVPPKIQRGPKHLKVQVGQR 1187

Query: 373  AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENST 432
                C AQG P   + W K G  +       +++ + TL +   +  D  IY CVA N  
Sbjct: 1188 VDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIA 1247

Query: 433  GSNQASARLVVTGGP-----EPP 450
            G+++    L V   P     EPP
Sbjct: 1248 GTDETEITLHVQEPPTVEDLEPP 1270



 Score = 99.8 bits (247), Expect = 7e-21
 Identities = 105/429 (24%), Positives = 169/429 (39%), Gaps = 80/429 (18%)

Query: 25   LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
            L +TV V  +P+ L C+  G P   I+W +D   L+  + +T +  G +    +    + 
Sbjct: 1928 LNETVLV-SNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQI----IDIESAQ 1982

Query: 85   PSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVAC-------FQCL 137
             S A  Y CVA N  G         +L    + H  P SI      VA         +C 
Sbjct: 1983 ISDAGIYKCVAINSAGA-------TELFYSLQVHVAP-SISGSNNMVAVVVNNPVRLECE 2034

Query: 138  IQGVPEPSISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHS 196
             +G+P PS++W  +G+ +++ ++ + +L  G IL +TS   +D G Y CVA N A  +  
Sbjct: 2035 ARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQR 2094

Query: 197  QDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIG 256
                       LR+   P I+   QN+++ + Q   L C + + P P ++W +     + 
Sbjct: 2095 DI--------DLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLK 2146

Query: 257  VEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG 316
              G+ + +  +   L I D  VQ +G Y C A                V G+ +    V 
Sbjct: 2147 KPGLSISE--NRSVLKIEDAQVQDTGRYTCEATN--------------VAGKTEKNYNVN 2190

Query: 317  RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFT 376
                         IW     GG                  E  Q    L+   G+     
Sbjct: 2191 -------------IWVPPNIGGS----------------DELTQ----LTVIEGNLISLL 2217

Query: 377  CVAQGVPESRLVWLKNGK-VLSPG-NNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
            C + G+P   L+W K G  VL+     +R+      L ++     D A+Y CVA N  G+
Sbjct: 2218 CESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGT 2277

Query: 435  NQASARLVV 443
             +    L V
Sbjct: 2278 AKKEYNLQV 2286



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 116/475 (24%), Positives = 176/475 (37%), Gaps = 105/475 (22%)

Query: 34   HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHC 93
            +P+ L C+    PP +++W +D   L +   V ++P G +    L   R+    A  Y C
Sbjct: 2793 NPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRV----LQIPRAKVEDAGRYTC 2848

Query: 94   VAQNRYGR-LVSRRARVQLASLSRFHQH--PESIEVERGGVACFQCLIQGVPEPSISWEH 150
            VA N  G   +    RV +  + +      PE + V     A  +CL  G P P  SW+ 
Sbjct: 2849 VAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK 2908

Query: 151  NGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
            +G  L   +H   L    IL I +   TD+G Y CVA N A    S      L+V     
Sbjct: 2909 DGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAG---SAKKYFNLNV----- 2960

Query: 211  LQEPEILSGP--QNLTLTVHQTAVLECIATSHPWPLVSW------SRLDGRSIGVEGIQV 262
               P  + GP  +NLT+ V+    L C  +  P P +SW       +L+  ++ V G + 
Sbjct: 2961 -HVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRT 3019

Query: 263  LDIL--------------------------------------DTGNLMISDVSVQHSGVY 284
            L I+                                      D+ +L + +V    S   
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSL 3079

Query: 285  VCAAN----------------RPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGA 328
             C +N                   THV   A G +L             + +   S TG 
Sbjct: 3080 ECESNAVPPPVITWYKNGRMITESTHVEILADGQML------------HIKKAEVSDTGQ 3127

Query: 329  WIWRGSRAGGK-----RLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVP 383
            ++ R     G+      L +  P S+    + PE     +++S P       TC A G+P
Sbjct: 3128 YVCRAINVAGRDDKNFHLNVYVPPSI----EGPEREVIVETISNP----VTLTCDATGIP 3179

Query: 384  ESRLVWLKNGKVL--SPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
               + WLKN K +  S    +R+    S L +A     D   Y C+A N  G  Q
Sbjct: 3180 PPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQ 3234



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 111/479 (23%), Positives = 178/479 (37%), Gaps = 96/479 (20%)

Query: 24   ELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRS 83
            EL     +  + + L C+  G PP ++ W++         G  ++ D    +  L   R 
Sbjct: 2202 ELTQLTVIEGNLISLLCESSGIPPPNLIWKK--------KGSPVLTDSMGRVRILSGGRQ 2253

Query: 84   LP------SRAHEYHCVAQNRYGRLVSRRARVQL---ASLSRFHQHPESIEVERGGVACF 134
            L       S A  Y CVA N  G    +   +Q+    +++    HP  I V RG     
Sbjct: 2254 LQISIAEKSDAALYSCVASNVAGT-AKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISL 2312

Query: 135  QCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTR 194
            +C +QG+P P+++W  +G  L  A     L    IL + ++  +D G Y CVA NVA   
Sbjct: 2313 ECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAG-- 2370

Query: 195  HSQDAQLTLSVGPLRLLQEPEILS---GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLD 251
               D +  LSV        P I+     P+N+++    +  L C A+  P P ++W + D
Sbjct: 2371 -MTDKKYDLSVH-----APPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFK-D 2423

Query: 252  GRSIGVEGIQVLDILDTGNLM-ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQ 310
            G  + +     + IL  G ++ +   +++ +G Y C         R+     +LV     
Sbjct: 2424 GWPVSLS--NSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIV 2481

Query: 311  GPNWVG--RVLEHPS-----SLTG------AWIWRGSR----------AGGKRLGLTAPS 347
            G N +   +V E  S      +TG       W   G            +GG+ L +T   
Sbjct: 2482 GENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQIT--- 2538

Query: 348  SMLLPAQLPEFVQWPQSLSKPPG---------------------------------SSAI 374
                  Q+P   ++    S P G                                 S   
Sbjct: 2539 ----NVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS 2594

Query: 375  FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTG 433
              C A   P + + W K+G  L    NIR+     TL +     ++   Y CVA N  G
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653



 Score = 92.8 bits (229), Expect = 9e-19
 Identities = 98/441 (22%), Positives = 164/441 (37%), Gaps = 67/441 (15%)

Query: 27   DTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPS 86
            D   +   P  L C+    PP +I+W +D   L +   + ++P G      L    +   
Sbjct: 2584 DVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGR----TLQILNAQED 2639

Query: 87   RAHEYHCVAQNRYGRLVSR-RARVQLASLSRFHQ------HPESIEVERGGVACFQCLIQ 139
             A  Y CVA N  G ++     +V +  +            P+ ++++       +C   
Sbjct: 2640 NAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAY 2699

Query: 140  GVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
             +P  S+SW  +G  L + +H         L I     +D G Y CVA N+A      D 
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG-EDELDF 2758

Query: 200  QLTLSVGP--LRLLQEPEILSGPQN---LTLTVHQTAVLECIATSHPWPLVSWSRLDGRS 254
             + + V P   +L +   +L   +N     + ++    L C   + P P ++W + DG  
Sbjct: 2759 DVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYK-DGHP 2817

Query: 255  IGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
            +     +VL +     L I    V+ +G Y C A      V    +  L          +
Sbjct: 2818 L-TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVA------VNEAGEDSL---------QY 2861

Query: 315  VGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAI 374
              RVL  P       I +G+ +                         P+ ++     SA+
Sbjct: 2862 DVRVLVPP-------IIKGANS-----------------------DLPEEVTVLVNKSAL 2891

Query: 375  FTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGS 434
              C++ G P  R  W K+G+ L   ++ +   N   L +    + D   Y CVAEN+ GS
Sbjct: 2892 IECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGS 2951

Query: 435  NQASARLVVTGGPEPPRPQGP 455
             +    L V     PP   GP
Sbjct: 2952 AKKYFNLNV---HVPPSVIGP 2969



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 98/427 (22%), Positives = 160/427 (37%), Gaps = 85/427 (19%)

Query: 36   LVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVA 95
            L L C+    P  S+SW +D   L ++  V +  +G      L  + +  S    Y CVA
Sbjct: 2692 LTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGH----TLQIKEAQISDTGRYTCVA 2747

Query: 96   QNRYGR-LVSRRARVQLA-SLSRFHQHPESIEVERGGVA---------CFQCLIQGVPEP 144
             N  G   +     +Q+  S  +  +    ++  R G A            C     P P
Sbjct: 2748 SNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPP 2807

Query: 145  SISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQ-DAQLT 202
            +++W  +G  L T++ +V +LP G +L I      D G Y CVA N A     Q D ++ 
Sbjct: 2808 TLTWYKDGHPL-TSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL 2866

Query: 203  LSVGPLRLLQEPEILSG-----PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV 257
            +          P I+ G     P+ +T+ V+++A++EC+++  P P  SW + DG+ +  
Sbjct: 2867 V----------PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQK-DGQPLLE 2915

Query: 258  EGIQVLDILDTGNLM-ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG 316
            +       L  G ++ I +  +   G YVC A                            
Sbjct: 2916 DDHH--KFLSNGRILQILNTQITDIGRYVCVAENTA------------------------ 2949

Query: 317  RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFT 376
                            GS      L +  P S++ P          ++L+    +    T
Sbjct: 2950 ----------------GSAKKYFNLNVHVPPSVIGPKS--------ENLTVVVNNFISLT 2985

Query: 377  CVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
            C   G P   L WLKN + +    N  +     TL +    V D   Y C+A N  G ++
Sbjct: 2986 CEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESK 3045

Query: 437  ASARLVV 443
                L V
Sbjct: 3046 KKFSLTV 3052



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 102/418 (24%), Positives = 156/418 (37%), Gaps = 78/418 (18%)

Query: 37  VLPCQVEGEPPVSISWQR-DR-LALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
           VL C +      +++WQR DR + LA  + +  + + SL L ++       + A EYHC+
Sbjct: 538 VLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKF-----NDAGEYHCM 592

Query: 95  AQNRYGRLVSRRARVQLASLS--RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNG 152
             +  G   S  A V L      +    P++     G      C   G P+P I+W  N 
Sbjct: 593 VSSEGG---SSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND 649

Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
             +   +HR  +   G L I + +  D G Y C+A N A T              LR ++
Sbjct: 650 MFI-VGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNST--------LRYIE 700

Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM 272
            P+++     L + +    V+EC  +  P P V W + D   +      ++D L  G L 
Sbjct: 701 APKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGD-LELRPSTFLIIDPL-LGLLK 758

Query: 273 ISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWR 332
           I +     +G Y C A                                         I  
Sbjct: 759 IQETQDLDAGDYTCVA-----------------------------------------INE 777

Query: 333 GSRAGGK-RLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVW-- 389
             RA GK  L + +P         P F+Q P  +S   GS+    C  QG PE  + W  
Sbjct: 778 AGRATGKITLDVGSP---------PVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRR 828

Query: 390 LKNGKVLSPGNNIRLTHNNST--LMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTG 445
           L N  + S   ++       T  L +  +   D+  Y C AEN  G  Q+   + VTG
Sbjct: 829 LDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG 886



 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 110/472 (23%), Positives = 187/472 (39%), Gaps = 70/472 (14%)

Query: 31   VWEHPLVLPCQVEGEPPVSISWQRDRLAL-ANESGVTLMPDGS-LHLAALPSRRSLPSRA 88
            V    + L CQV+G P   I W +D   L   +  V L+  G  LHL    +RR+   R 
Sbjct: 1466 VLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKN--ARRNDKGR- 1522

Query: 89   HEYHCVAQNRYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSIS 147
              Y C   N  G+     +  + +    +       I V    +   +C  +G+P P+I+
Sbjct: 1523 --YQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAIT 1580

Query: 148  WEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGP 207
            W  +G  + +++  + +     LHI     +D  TY C   NVA T   +   + + V P
Sbjct: 1581 WYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTA-EKSFHVDVYVPP 1639

Query: 208  LRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV-EGIQVLDIL 266
            +        L+ P N  + +  +  LEC A  +P P+++W + DG  +   + I++    
Sbjct: 1640 M----IEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLK-DGVPVKANDNIRI---- 1690

Query: 267  DTGNLMISDVSVQH--SGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPN-------WVGR 317
            + G   +  +S Q    G Y+C A           +  +LV    +G +        V  
Sbjct: 1691 EAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNN 1750

Query: 318  VLEHPSSLTGA------WIWRG---SRAGGKRLGLTAPSSMLLPAQL------------- 355
            +LE    +TG+      W+  G       G ++ L     ++  AQ+             
Sbjct: 1751 LLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANT 1810

Query: 356  -----PEF---VQWPQSLSKPPGSSAI--------FTCVAQGVPESRLVWLKNGK-VLSP 398
                  EF   V  P ++     S  +          C+A G+P   + WLK+ + V + 
Sbjct: 1811 AGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTA 1870

Query: 399  GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
              N+++  +   L +A   +ED   Y CVA N+ G  Q   +L V    EPP
Sbjct: 1871 QGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHV---HEPP 1919



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 99/432 (22%), Positives = 156/432 (36%), Gaps = 70/432 (16%)

Query: 34   HPLVLPCQVEGEPPVSISWQRDRLALANESG--VTLMPDGSLHLAALPSRRSLPSRAHEY 91
            +P+ L C   G PP +I+W ++   + N     V ++  GS     L   RS  S +  Y
Sbjct: 3167 NPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGS----KLQIARSQHSDSGNY 3222

Query: 92   HCVAQNRYGRLVSRR-ARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEH 150
             C+A N  G+        +Q+       + P  + V  G      C   G+P P I W  
Sbjct: 3223 TCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLK 3282

Query: 151  NGTALNTAN-HRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPL 208
            +G  + +    R+ +  +G  L+I     +D G Y CVA N A     +   L + V P 
Sbjct: 3283 DGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAG-EEDRIFNLNVYVTPT 3341

Query: 209  RLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
                + E     + L   V  +  +EC AT  P P ++W +     + +     + +L  
Sbjct: 3342 IRGNKDEA----EKLMTLVDTSINIECRATGTPPPQINWLK---NGLPLPLSSHIRLLAA 3394

Query: 269  GNLM-ISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
            G ++ I    V    VY C A+NR G   +      L V   P   N +G          
Sbjct: 3395 GQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYN---LQVFAPPNMDNSMGT--------- 3442

Query: 327  GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
                                                + ++   GSS    C+  G P   
Sbjct: 3443 ------------------------------------EEITVLKGSSTSMACITDGTPAPS 3466

Query: 387  LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
            + WL++G+ L    ++ ++ +   L L     ED   Y C+A N  G       L V   
Sbjct: 3467 MAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL-- 3524

Query: 447  PEPPRPQGPACH 458
             EPP   G   H
Sbjct: 3525 -EPPHINGSEEH 3535



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 96/413 (23%), Positives = 148/413 (35%), Gaps = 70/413 (16%)

Query: 37   VLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQ 96
            V+ C+  G PP  + W +  L L       L+ D  L L  +   + L   A +Y CVA 
Sbjct: 720  VMECKTSGIPPPQVKWFKGDLEL--RPSTFLIIDPLLGLLKIQETQDLD--AGDYTCVAI 775

Query: 97   NRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGT--- 153
            N  GR   +   + + S   F Q P  + +E G      C +QG PEP+I W        
Sbjct: 776  NEAGRATGK-ITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI 834

Query: 154  -ALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
             +   +   ++ L +G L I ++  +D GTY C A N      S+             L 
Sbjct: 835  FSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTG------LV 888

Query: 213  EPEILSGPQNLTLTVHQTAVLEC-IATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
             P I   P    +   Q   L C +   +P P   W +    S  +     + +   G+L
Sbjct: 889  APLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIK---NSAMLLQNPYITVRSDGSL 945

Query: 272  MISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWI 330
             I  V +Q  G Y C A+N  GT+ + T+                  V+ H         
Sbjct: 946  HIERVQLQDGGEYTCVASNVAGTNNKTTS------------------VVVH--------- 978

Query: 331  WRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWL 390
                                    LP      Q LS   G      C A G P+  ++W 
Sbjct: 979  -----------------------VLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWS 1015

Query: 391  KNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVV 443
            K G+++S  +       + +L +     E+   Y C A N+ G  +   +L V
Sbjct: 1016 KKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTV 1068



 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 96/450 (21%), Positives = 173/450 (38%), Gaps = 66/450 (14%)

Query: 39   PCQVEGEPPVSISWQRD-RLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
            PC  +G P  +I W  + R     E G++++ DG+L + A  +    P    EY CVA N
Sbjct: 1287 PCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVT----PYDNGEYICVAVN 1342

Query: 98   RYGRLVSR-RARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALN 156
              G    +   +V +  + +  +   ++ V    +    C ++G P P I W  +   + 
Sbjct: 1343 EAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT 1402

Query: 157  TANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEI 216
             ++   T+    IL +   +  D G Y C A N+A T     +Q   ++    +L  P I
Sbjct: 1403 ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT-----SQKYFNID---VLVPPTI 1454

Query: 217  L--SGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM-I 273
            +  + P  +++ +++   LEC     P+P + W + DG+ + + G   +++LD G ++ +
Sbjct: 1455 IGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFK-DGKPLFL-GDPNVELLDRGQVLHL 1512

Query: 274  SDVSVQHSGVYVC----AANRPGTHVRRT-------------------AQGVLLVQGEPQ 310
             +      G Y C    AA +    ++ T                      ++ ++ E +
Sbjct: 1513 KNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETR 1572

Query: 311  G-----PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGL---------------TAPSSML 350
            G       W        SS    +I +G      R  +               TA  S  
Sbjct: 1573 GLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFH 1632

Query: 351  LPAQLPEFVQ----WPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTH 406
            +   +P  ++     P +       S    C A G P   L WLK+G  +   +NIR+  
Sbjct: 1633 VDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEA 1692

Query: 407  NNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
                L +      D   Y CVA +  G  +
Sbjct: 1693 GGKKLEIMSAQEIDRGQYICVATSVAGEKE 1722



 Score = 80.9 bits (198), Expect = 3e-15
 Identities = 91/420 (21%), Positives = 153/420 (36%), Gaps = 70/420 (16%)

Query: 34   HPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAH---- 89
            H L L C+  G P   ++W +D        GV +  + ++ + A   +  + S       
Sbjct: 1657 HSLTLECKAAGNPSPILTWLKD--------GVPVKANDNIRIEAGGKKLEIMSAQEIDRG 1708

Query: 90   EYHCVAQNRYG-RLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISW 148
            +Y CVA +  G + +     V +              V    +    C + G P P+I W
Sbjct: 1709 QYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMW 1768

Query: 149  EHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPL 208
              +G  ++  +    LL    L I     ++ G YRC+A N A   H ++ ++T+ V P 
Sbjct: 1769 LKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD-HKKEFEVTVHVPPT 1827

Query: 209  RLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDT 268
                     SG     +  ++   L+CIA   P P ++W + D      +G   L I  +
Sbjct: 1828 IK------SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQG--NLKIQSS 1879

Query: 269  GN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTG 327
            G  L I+   ++ +G Y C A         T Q + L   EP      G++L     ++ 
Sbjct: 1880 GRVLQIAKTLLEDAGRYTCVATNA---AGETQQHIQLHVHEPPSLEDAGKMLNETVLVSN 1936

Query: 328  AWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRL 387
                                    P QL                     C A G P   +
Sbjct: 1937 ------------------------PVQL--------------------ECKAAGNPVPVI 1952

Query: 388  VWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
             W K+ ++LS   ++   +    + +    + D  IY+CVA NS G+ +    L V   P
Sbjct: 1953 TWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAP 2012



 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 100/435 (22%), Positives = 157/435 (36%), Gaps = 90/435 (20%)

Query: 38   LPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQN 97
            L C+    PP  I+W ++   +   + V ++ DG +    L  +++  S   +Y C A N
Sbjct: 3079 LECESNAVPPPVITWYKNGRMITESTHVEILADGQM----LHIKKAEVSDTGQYVCRAIN 3134

Query: 98   RYGRLVSRRARVQLASLSRFHQH---PESIEVERGGV--------ACFQCLIQGVPEPSI 146
              GR               FH +   P SIE     V            C   G+P P+I
Sbjct: 3135 VAGR-----------DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTI 3183

Query: 147  SWEHNGTAL-NTANHRVTLLPSGI-LHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLS 204
            +W  N   + N+ +  V +L  G  L I     +D G Y C+A N+            LS
Sbjct: 3184 AWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKY---YFLS 3240

Query: 205  VGPLRLLQEPEILSG---PQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQ 261
            +      Q P  ++G   P ++++ + +   L C A   P PL+ W + DG+ I     +
Sbjct: 3241 I------QVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLK-DGKPIASGETE 3293

Query: 262  VLDILDTGN-LMISDVSVQHSGVYVC-AANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVL 319
             + +   G+ L I       +G Y C A N  G   R     V +               
Sbjct: 3294 RIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTP------------- 3340

Query: 320  EHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVA 379
                        RG++   ++L     +S+ +                         C A
Sbjct: 3341 ----------TIRGNKDEAEKLMTLVDTSINIE------------------------CRA 3366

Query: 380  QGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASA 439
             G P  ++ WLKNG  L   ++IRL      + +    V D A+Y CVA N  G +    
Sbjct: 3367 TGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHY 3426

Query: 440  RLVVTGGPEPPRPQG 454
             L V   P      G
Sbjct: 3427 NLQVFAPPNMDNSMG 3441



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 99/425 (23%), Positives = 150/425 (35%), Gaps = 86/425 (20%)

Query: 25   LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESG-VTLMPDGSLHLAALPSRRS 83
            L + V V   P+ L C   G P  SI+W +D   +    G + +   G +    L   ++
Sbjct: 1833 LSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV----LQIAKT 1888

Query: 84   LPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH-PESIE---------VERGGVAC 133
            L   A  Y CVA N  G     +  +QL      H H P S+E         V       
Sbjct: 1889 LLEDAGRYTCVATNAAGET---QQHIQL------HVHEPPSLEDAGKMLNETVLVSNPVQ 1939

Query: 134  FQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVAST 193
             +C   G P P I+W  +   L+ +     L    I+ I S   +D G Y+CVA N A  
Sbjct: 1940 LECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGA 1999

Query: 194  RHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGR 253
                  +L  S   L++   P I      + + V+    LEC A   P P ++W + DG 
Sbjct: 2000 -----TELFYS---LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLK-DGS 2050

Query: 254  SIG--VEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
             +     G+QVL       L ++   +  +G Y C A       +R     + V      
Sbjct: 2051 PVSSFSNGLQVLS--GGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVP----- 2103

Query: 312  PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGS 371
            PN +G                                              Q++S     
Sbjct: 2104 PNIMGE--------------------------------------------EQNVSVLISQ 2119

Query: 372  SAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENS 431
            +    C +  +P   L WLK+G  L     + ++ N S L +    V+D   Y C A N 
Sbjct: 2120 AVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNV 2179

Query: 432  TGSNQ 436
             G  +
Sbjct: 2180 AGKTE 2184



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 77/296 (26%), Positives = 115/296 (38%), Gaps = 21/296 (7%)

Query: 21   FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
            F +  GD        L L C+  G P   ++W        N + +    D     + L  
Sbjct: 4262 FTELPGDVSLNKGEQLRLSCKATGIPLPKLTWT------FNNNIIPAHFDSVNGHSELVI 4315

Query: 81   RRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFH-QHPESIEVERGGVACFQCLIQ 139
             R     +  Y C A+N  G  V     V +     F   +P +     GG A   C ++
Sbjct: 4316 ERVSKEDSGTYVCTAENSVG-FVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVK 4374

Query: 140  GVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDA 199
            G P P+I W   G  +  + HR+  L +G L I      D G Y CVA N A     +  
Sbjct: 4375 GDPTPTIQWNRKGVDIEIS-HRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVE-RSM 4432

Query: 200  QLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEG 259
             LTL   P+  L+       P    +      +L C AT  P P ++WSR  G SI  + 
Sbjct: 4433 SLTLQSPPIITLE-------PVETVINAGGKIILNCQATGEPQPTITWSR-QGHSISWD- 4483

Query: 260  IQVLDILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQGPNW 314
               +++L   +L I+D   + +  + C A N  G+ + R    V +  G  Q   W
Sbjct: 4484 -DRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAW 4538



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 96/436 (22%), Positives = 162/436 (37%), Gaps = 71/436 (16%)

Query: 25   LGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSL 84
            L D     +  + L C+V G P   I+W +D   L  +    ++  G      L      
Sbjct: 2486 LEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRF----LQITNVQ 2541

Query: 85   PSRAHEYHCVAQNRYG---RLVSRRARVQ--LASLSRFHQHPESIEVERGGVACFQCLIQ 139
                  Y C+A +  G   R  S    V   +A +     +PE + V         C   
Sbjct: 2542 VPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGS-DGNPEDVTVILNSPTSLVCEAY 2600

Query: 140  GVPEPSISWEHNGTALNTANHRVTLLPSG-ILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
              P  +I+W  +GT L  +N  + +LP G  L I +  + + G Y CVA N A     + 
Sbjct: 2601 SYPPATITWFKDGTPLE-SNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG-EMIKH 2658

Query: 199  AQLTLSVGPLRLLQEPEILS---GPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
             ++ + + P  ++ + ++      P+ + + V+ T  LEC A + P   +SW + DG+ +
Sbjct: 2659 YEVKVYIPP--IINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYK-DGQPL 2715

Query: 256  GVEGIQVLDILDTGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNW 314
              +    ++I   G+ L I +  +  +G Y C A+               + GE +    
Sbjct: 2716 --KSDDHVNIAANGHTLQIKEAQISDTGRYTCVASN--------------IAGEDELDFD 2759

Query: 315  VGRVLEHPSSLTGAW-----IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPP 369
            V   ++ P S    W     +  G     K + +  P S+                    
Sbjct: 2760 VN--IQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLY------------------- 2798

Query: 370  GSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAE 429
                   C     P   L W K+G  L+  + + +      L +    VED   Y CVA 
Sbjct: 2799 -------CETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAV 2851

Query: 430  NSTG--SNQASARLVV 443
            N  G  S Q   R++V
Sbjct: 2852 NEAGEDSLQYDVRVLV 2867



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 51/194 (26%), Positives = 86/194 (44%), Gaps = 23/194 (11%)

Query: 13   CAAGSELAFVQELG------------DTVAVWEHPL----VLPCQVEGEPPVSISWQRDR 56
            C A + + FV+ +G            D  + W  PL    +L C+V+G+P  +I W R  
Sbjct: 4328 CTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKG 4387

Query: 57   LALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSR 116
            + +     +  + +GSL +       ++   A +Y CVA N  G +V R   + L S   
Sbjct: 4388 VDIEISHRIRQLGNGSLAIYG-----TVNEDAGDYTCVATNEAG-VVERSMSLTLQSPPI 4441

Query: 117  FHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVS 176
                P    +  GG     C   G P+P+I+W   G +++  + RV +L +  L+I    
Sbjct: 4442 ITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISW-DDRVNVLSNNSLYIADAQ 4500

Query: 177  QTDMGTYRCVAWNV 190
            + D   + CVA N+
Sbjct: 4501 KEDTSEFECVARNL 4514



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 77/355 (21%), Positives = 131/355 (36%), Gaps = 63/355 (17%)

Query: 136 CLIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRH 195
           C +  +   ++S+  NG  L    + +    S  L I  V+ +D G Y C+A + A T  
Sbjct: 451 CSVDSLLPFTLSFVRNGVTLGVDQY-LKESASVNLDIAKVTLSDEGFYECIAVSSAGTGR 509

Query: 196 SQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSI 255
           +Q            + + P ++  P N+T+T  + AVL C+  S     ++W R D R +
Sbjct: 510 AQTF--------FDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRND-RDV 560

Query: 256 GVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWV 315
            +     +  L   +L +  V    +G Y C  +  G                       
Sbjct: 561 RLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG----------------------- 597

Query: 316 GRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIF 375
                                     G +A S  L   + P+    P++ S   GS    
Sbjct: 598 --------------------------GSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSI 631

Query: 376 TCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSN 435
            C A G P+ ++ W  N   +   +  R+T ++ TL +   + +D  IY C+A NS G++
Sbjct: 632 MCSATGYPKPKIAWTVNDMFIVGSHRYRMT-SDGTLFIKNAAPKDAGIYGCLASNSAGTD 690

Query: 436 QASARLVVTGGPEPPRPQGP--ACHGSLYFCHSSVLGATPPSSRDIIGYVLHLRP 488
           + ++ L     P+    Q       G +        G  PP  +   G  L LRP
Sbjct: 691 KQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKG-DLELRP 744



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 93/421 (22%), Positives = 149/421 (35%), Gaps = 64/421 (15%)

Query: 31   VWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHE 90
            V  +P+ L C+  G P  S++W +D   +++ S    +  G   LA   ++ S   R   
Sbjct: 2024 VVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGR--- 2080

Query: 91   YHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEH 150
            Y CVA N  G    R   +++          +++ V         C    +P P+++W  
Sbjct: 2081 YTCVAVNAAGEK-QRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLK 2139

Query: 151  NGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRL 210
            +G  L             +L I      D G Y C A NVA  +  ++  + + V     
Sbjct: 2140 DGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG-KTEKNYNVNIWV----- 2193

Query: 211  LQEPEILSGPQNLT-LTVHQTAVLE--CIATSHPWPLVSWSRLDGRSIGVEGIQVLDILD 267
               P  + G   LT LTV +  ++   C ++  P P + W +  G  +  + +  + IL 
Sbjct: 2194 ---PPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKK-KGSPVLTDSMGRVRILS 2249

Query: 268  TGN-LMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLT 326
             G  L IS      + +Y C A    ++V  TA+    +Q           V   P+   
Sbjct: 2250 GGRQLQISIAEKSDAALYSCVA----SNVAGTAKKEYNLQ-----------VYIRPTITN 2294

Query: 327  GAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
                  GS                           P  +    G S    C  QG+P   
Sbjct: 2295 S-----GSH--------------------------PTEIIVTRGKSISLECEVQGIPPPT 2323

Query: 387  LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGG 446
            + W+K+G  L     + +      L L  + V D   Y CVA N  G       L V   
Sbjct: 2324 VTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAP 2383

Query: 447  P 447
            P
Sbjct: 2384 P 2384


>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
           [Homo sapiens]
          Length = 1030

 Score =  122 bits (306), Expect = 1e-27
 Identities = 115/446 (25%), Positives = 177/446 (39%), Gaps = 42/446 (9%)

Query: 27  DTVAVWEHPLVLPCQVEGEPPVSISWQ-RDRLALANESG------VTLMPDGSLHLAALP 79
           D V       +  CQ   +PP S+ W   D   + N S        T+  +GSL L  + 
Sbjct: 233 DVVVARYEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVR 292

Query: 80  SRRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLI- 138
                P  A  Y C+ Q + G  +   A + LA +         +    G      CL  
Sbjct: 293 -----PRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRV-FTAGSEERVTCLPP 346

Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
           +G+PEPS+ WEH G  L T  H         L + +++++D G Y C A N+A  R  QD
Sbjct: 347 KGLPEPSVWWEHAGVRLPT--HGRVYQKGHELVLANIAESDAGVYTCHAANLAGQRR-QD 403

Query: 199 AQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVE 258
             +T++         P  L  PQ+  L   +   L+C+  + P P V W R     + + 
Sbjct: 404 VNITVAT-------VPSWLKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYR---NQMLIS 453

Query: 259 GIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRV 318
                ++   G L I+ V V     Y C ++ P   +   A+ V ++ G    P WV   
Sbjct: 454 EDSRFEVFKNGTLRINSVEVYDGTWYRCMSSTPAGSIEAQAR-VQVLDGSSL-PEWV--- 508

Query: 319 LEHPSSLTGAWIWRGSRAGGKRLGLTAPSSM------LLPAQLPEFVQWPQSLSKPPGSS 372
            ++  +L  A + R        +    P         L  A    F   P+  +   G +
Sbjct: 509 TDNAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHT 568

Query: 373 AIFTCVAQGVPESRLVWLKNGKVLSP---GNNIRLTHNNSTLMLAGVSVEDEAIYQCVAE 429
           A+  C AQG P+  + W    ++L P   G  + +  N S L++  V+ ED   Y C+A 
Sbjct: 569 ALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGS-LVIHDVAPEDSGRYTCIAG 627

Query: 430 NSTGSNQASARLVVTGGPEPPRPQGP 455
           NS       A L V   P P   +GP
Sbjct: 628 NSCNIKHTEAPLYVVDKPVPEESEGP 653



 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 111/512 (21%), Positives = 194/512 (37%), Gaps = 87/512 (16%)

Query: 3   LLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANE 62
           L +LLLP  G    + + F+++     A+     +L C+VE   PV + W  D  A   +
Sbjct: 17  LSVLLLPLLG-GTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVHVYWLLDG-APVQD 74

Query: 63  SGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQ-----LASLSRF 117
           +        SL  AA+   +     +  + CVA++      +R A        + +    
Sbjct: 75  TERRFAQGSSLSFAAVDRLQD----SGTFQCVARDDVTGEEARSANASFNIKWIEAGPVV 130

Query: 118 HQHPES-IEVERGGVACFQCLIQGVPEPSISWEHNGTALN--TANHRV-------TLLPS 167
            +HP S  E++       +C I G P P+  W  +GT L+   +NH V       TL P+
Sbjct: 131 LKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPA 190

Query: 168 GILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTV 227
           G  H         G Y C A + A  +       TLS+      +   ++  PQ++ +  
Sbjct: 191 GPEH--------SGLYSCCA-HSAFGQACSSQNFTLSIADESFAR---VVLAPQDVVVAR 238

Query: 228 HQTAVLECIATSHPWPLVSWSRLDGRSIGVEG----IQVLDILDTGNLMISDVSVQHSGV 283
           ++ A+  C  ++ P P + W   D   I        ++   +   G+L+++ V  +++G+
Sbjct: 239 YEEAMFHCQFSAQPPPSLQWLFEDETPITNRSRPPHLRRATVFANGSLLLTQVRPRNAGI 298

Query: 284 YVCAAN------------------------RPGTHVRRTAQGV--LLVQGEPQGPNW--- 314
           Y C                            P      + + V  L  +G P+   W   
Sbjct: 299 YRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVTCLPPKGLPEPSVWWEH 358

Query: 315 -------VGRVLEHPSSL---------TGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEF 358
                   GRV +    L          G +    +   G+R         +  A +P +
Sbjct: 359 AGVRLPTHGRVYQKGHELVLANIAESDAGVYTCHAANLAGQR----RQDVNITVATVPSW 414

Query: 359 VQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSV 418
           ++ PQ      G      C+ Q  P+  +VW +N  ++S  +   +   N TL +  V V
Sbjct: 415 LKKPQDSQLEEGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEV-FKNGTLRINSVEV 473

Query: 419 EDEAIYQCVAENSTGSNQASARLVVTGGPEPP 450
            D   Y+C++    GS +A AR+ V  G   P
Sbjct: 474 YDGTWYRCMSSTPAGSIEAQARVQVLDGSSLP 505



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 32/114 (28%), Positives = 47/114 (41%), Gaps = 9/114 (7%)

Query: 332 RGSRAGGKRLGLTAPSSMLLPA-----QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR 386
           RGS A  +RL L   S +LLP          F++ P S     G  A+  C  +      
Sbjct: 5   RGSPARPRRLPLL--SVLLLPLLGGTQTAIVFIKQPSSQDALQGRRALLRCEVEAPGPVH 62

Query: 387 LVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVA-ENSTGSNQASA 439
           + WL +G  +      R    +S    A   ++D   +QCVA ++ TG    SA
Sbjct: 63  VYWLLDGAPVQDTER-RFAQGSSLSFAAVDRLQDSGTFQCVARDDVTGEEARSA 115


>gi|126517478 peroxidasin homolog-like [Homo sapiens]
          Length = 1463

 Score =  118 bits (296), Expect = 1e-26
 Identities = 95/375 (25%), Positives = 156/375 (41%), Gaps = 67/375 (17%)

Query: 121 PESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANH-RVTLLPSGILHITSVSQTD 179
           P+ +EV  G    F C  +G P+P I W HN  +L+  +  R+ +   G L I +  ++D
Sbjct: 240 PQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESD 299

Query: 180 MGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATS 239
            G Y+C+A N A    +Q A L  S  P +    P  +  PQ+  + +  +  LEC+AT 
Sbjct: 300 QGVYQCMARNSAGEAKTQSAMLRYSSLPAK----PSFVIQPQDTEVLIGTSTTLECMATG 355

Query: 240 HPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTA 299
           HP PL++W+R +G  + ++G +   +  +  L + +++ +  G + C AN   +H    A
Sbjct: 356 HPHPLITWTRDNG--LELDGSR--HVATSSGLYLQNITQRDHGRFTCHAN--NSHGTVQA 409

Query: 300 QGVLLVQGEPQ--------------GPNWVGRVLEHPSSLTGAWIWRGSRAGGK------ 339
              ++VQ  PQ                 W+     +P  +    +W  ++ GG+      
Sbjct: 410 AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVI---VW--TKTGGQLPVEGQ 464

Query: 340 ----------------------------RLGLTAPSSMLL--PAQLPEFVQWPQSLSKPP 369
                                        LG+   S  L   P  L  F Q PQ  S   
Sbjct: 465 HTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEV 524

Query: 370 GSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAE 429
           G +   +C AQG P+  + W K G  ++      +  +  TL +      D+  Y+CVA 
Sbjct: 525 GKNINISCHAQGEPQPIITWNKEGVQITESGKFHV-DDEGTLTIYDAGFPDQGRYECVAR 583

Query: 430 NSTGSNQASARLVVT 444
           NS G    +  L VT
Sbjct: 584 NSFGLAVTNMFLTVT 598



 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 83/305 (27%), Positives = 126/305 (41%), Gaps = 34/305 (11%)

Query: 20  AFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALP 79
           +FV +  DT  +      L C   G P   I+W RD       +G+ L  DGS H+A   
Sbjct: 331 SFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRD-------NGLEL--DGSRHVATSS 381

Query: 80  SR--RSLPSRAH-EYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQC 136
               +++  R H  + C A N +G  V   A + + +  +F   P+   V       + C
Sbjct: 382 GLYLQNITQRDHGRFTCHANNSHGT-VQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLC 440

Query: 137 LIQGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHS 196
              G P P I W   G  L       T+L SG L I   +Q D G Y C A    S+   
Sbjct: 441 EADGNPPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQA---VSSLGV 496

Query: 197 QDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIG 256
           +   + L+V P  L    ++   PQ+ ++ V +   + C A   P P+++W++       
Sbjct: 497 KKVSVQLTVKPKALAVFTQL---PQDTSVEVGKNINISCHAQGEPQPIITWNK------- 546

Query: 257 VEGIQVLD-----ILDTGNLMISDVSVQHSGVYVCAA-NRPGTHVRRTAQGVLLVQGEPQ 310
            EG+Q+ +     + D G L I D      G Y C A N  G  V      V  +QG   
Sbjct: 547 -EGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQA 605

Query: 311 GPNWV 315
           G ++V
Sbjct: 606 GDDFV 610



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 60/237 (25%), Positives = 91/237 (38%), Gaps = 48/237 (20%)

Query: 212 QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
           Q P I   PQ++ +    T    C A  +P P + W   +  S+ +E    L++ D G L
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIH-NNHSLDLEDDTRLNVFDDGTL 290

Query: 272 MISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIW 331
           MI +      GVY C A        R + G    Q           +L + S        
Sbjct: 291 MIRNTRESDQGVYQCMA--------RNSAGEAKTQSA---------MLRYSS-------- 325

Query: 332 RGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLK 391
                              LPA+ P FV  PQ      G+S    C+A G P   + W +
Sbjct: 326 -------------------LPAK-PSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTR 365

Query: 392 NGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPE 448
           +  +   G+  R    +S L L  ++  D   + C A NS G+ QA+A ++V   P+
Sbjct: 366 DNGLELDGS--RHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQ 420



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 33/99 (33%), Positives = 51/99 (51%), Gaps = 2/99 (2%)

Query: 354 QLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRL-THNNSTLM 412
           Q P     PQ +  P G++  FTC A+G P+  ++W+ N   L   ++ RL   ++ TLM
Sbjct: 232 QSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLM 291

Query: 413 LAGVSVEDEAIYQCVAENSTG-SNQASARLVVTGGPEPP 450
           +      D+ +YQC+A NS G +   SA L  +  P  P
Sbjct: 292 IRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKP 330


>gi|15147240 brother of CDO [Homo sapiens]
          Length = 1114

 Score =  117 bits (294), Expect = 3e-26
 Identities = 149/618 (24%), Positives = 232/618 (37%), Gaps = 151/618 (24%)

Query: 3   LLLLLLPGWGCAAG---------SELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQ 53
           L  LLL   GC A             + VQ+ G TV       +L C VE  P ++++W+
Sbjct: 18  LACLLLATAGCFADLNEVPQVTVQPASTVQKPGGTV-------ILGCVVE-PPRMNVTWR 69

Query: 54  RDRLAL--ANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQL 111
            +   L  ++++   L+  G+L + AL +          Y CVA+   G + S  A V L
Sbjct: 70  LNGKELNGSDDALGVLITHGTLVITALNNHT-----VGRYQCVARMPAGAVASVPATVTL 124

Query: 112 ASLSRFHQHPES-IEVERGGVACFQC-LIQGVPEPSISWEHNGTALNTANHRVTLLPSGI 169
           A+L  F    +  IEV+ G  A   C L +  P+  + +      L  +     ++PSG 
Sbjct: 125 ANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLEASRGNYLIMPSGN 184

Query: 170 LHITSVSQTDMGTYRCVAWN-----VASTRHSQDAQLTLSVG-PLRLLQEPEILSGPQNL 223
           L I + SQ D G Y+C A+N     V ++  S   ++  S     R++  PE     Q +
Sbjct: 185 LQIVNASQEDEGMYKCAAYNPVTQEVKTSGSSDRLRVRRSTAEAARIIYPPE----AQTI 240

Query: 224 TLTVHQTAVLECIATSHPWPLVSWSRLDGRSI-GVEGIQVLDILDTGNLMISDVSVQHSG 282
            +T  Q+ +LEC+A+  P P V+W++ DG S+ G    + L      NL+I   S + SG
Sbjct: 241 IVTKGQSLILECVASGIPPPRVTWAK-DGSSVTGYNKTRFL----LSNLLIDTTSEEDSG 295

Query: 283 VYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLG 342
            Y C A+     V +    V+L   +   P                              
Sbjct: 296 TYRCMAD---NGVGQPGAAVILYNVQVFEP------------------------------ 322

Query: 343 LTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNI 402
                        PE       L  P G SA  TC  +G P   ++WL+N   L     +
Sbjct: 323 -------------PEVTMELSQLVIPWGQSAKLTCEVRGNPPPSVLWLRNAVPLISSQRL 369

Query: 403 RLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARL----------------VVTGG 446
           RL+     L +  +  EDE +YQC+AEN  GS  A  +L                + TG 
Sbjct: 370 RLSRR--ALRVLSMGPEDEGVYQCMAENEVGSAHAVVQLRTSRPSITPRLWQDAELATGT 427

Query: 447 PE---------------------------PPRPQGPACHGSLYFCHSSVLGATPPSSR-- 477
           P                            P  PQ P   G      + ++ ++P +S+  
Sbjct: 428 PPVSPSKLGNPEQMLRGQPALPRPPTSVGPASPQCPGEKGQGAPAEAPIILSSPRTSKTD 487

Query: 478 ----------------DIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTI 521
                            I+ YV+  R V   S       I         + L+P + Y +
Sbjct: 488 SYELVWRPRHEGSGRAPILYYVVKHRKVTNSSDDWTISGIPANQHRLTLTRLDPGSLYEV 547

Query: 522 HLRAYSAEGASQDSAPIF 539
            + AY+  G  Q +   F
Sbjct: 548 EMAAYNCAGEGQTAMVTF 565



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 30/99 (30%), Positives = 40/99 (40%), Gaps = 15/99 (15%)

Query: 569 EPAALYDIKLQAFNGNGDGN-------------SSARCVSLRDVPLATPDGTV--STESK 613
           +P   YDIK+Q FN  G+               SS +   L    LA P   +  + E  
Sbjct: 781 QPETSYDIKMQCFNEGGESEFSNVMICETKARKSSGQPGRLPPPTLAPPQPPLPETIERP 840

Query: 614 TGCSCSQGESSPLPGVVVGIHVGLAALIICLLCLFLGWR 652
            G       SS LP ++VG+ +G   LII     F  WR
Sbjct: 841 VGTGAMVARSSDLPYLIVGVVLGSIVLIIVTFIPFCLWR 879


>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
          Length = 1215

 Score =  110 bits (276), Expect = 3e-24
 Identities = 120/464 (25%), Positives = 175/464 (37%), Gaps = 81/464 (17%)

Query: 40  CQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRY 99
           C   G P   ISW R+  AL  +S + +   G+L +  +      P  A  Y C A N  
Sbjct: 512 CSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVA-----PEDAGNYSCQATNEV 566

Query: 100 GRLVSRRARVQLASLSRFHQHPESIE-------VERGGVACFQCLIQGVPEPSISWEHNG 152
           G            +++ ++  P S+        V  G  A   C   GVP P + W   G
Sbjct: 567 G--------TDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 618

Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
             +  A    +   SG L I +  + D GTY C A N         A++ L+VG      
Sbjct: 619 LEMILAPEGSS---SGKLRIPAAQERDAGTYTCRAVNELG---DASAEIQLAVG-----H 667

Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGV-----EGIQVLDILD 267
            P++   P+++T+ + ++A+L C AT  P P V+W R DG+ +G+      G +     D
Sbjct: 668 APQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQ-PD 726

Query: 268 TGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG--RVLE-HPSS 324
           +G L    V+ +    YVC A      V+  A+ ++     PQ  +     RVLE  P S
Sbjct: 727 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVS 786

Query: 325 L-----------TGAWIWRG-SRAGGKRLGLTAPSSMLLPAQLPE--------------- 357
           L              W+  G     G R  + A  S+ L   L E               
Sbjct: 787 LPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGS 846

Query: 358 -------FVQWPQSLSKP-------PGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIR 403
                   VQ P  +           G  A   CVA GVP   + W K    L+      
Sbjct: 847 QHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHY 906

Query: 404 LTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGP 447
                 TL++A  S +D   Y C A N+ G +    RL V   P
Sbjct: 907 NVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKP 950



 Score =  103 bits (257), Expect = 5e-22
 Identities = 93/304 (30%), Positives = 130/304 (42%), Gaps = 17/304 (5%)

Query: 28   TVAVWE-HPLVLPCQV-EGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLP 85
            TV V E  P+ LPC V  G P     W +D   L   S  ++  DGSLHL      R+L 
Sbjct: 776  TVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLD-----RALQ 830

Query: 86   SRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQHPESIE--VERGGVACFQCLIQGVPE 143
              A  Y CVA N  G   S+   V+L        HP +       G  A   C+  GVP 
Sbjct: 831  EHAGRYSCVATNTAG---SQHRDVELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPA 887

Query: 144  PSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTL 203
            P+I+W     AL +      +   G L I   S  D G Y C A N      SQ+ +L++
Sbjct: 888  PTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGF-SSQEMRLSV 946

Query: 204  SVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVL 263
            +  P   +      + P  +T    +   L+C A   P PLV+W++ D R +        
Sbjct: 947  NTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTK-DSRPV-PPITNRY 1004

Query: 264  DILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPS 323
             +L +G+L ++ V V  SG Y C A+ P      + + VL VQG          V  HP+
Sbjct: 1005 GLLPSGSLRLAQVQVGDSGHYECTASNPAGSA--SHRYVLGVQGRTSWQPQSLPVPHHPA 1062

Query: 324  SLTG 327
             L+G
Sbjct: 1063 CLSG 1066



 Score = 94.0 bits (232), Expect = 4e-19
 Identities = 118/475 (24%), Positives = 180/475 (37%), Gaps = 106/475 (22%)

Query: 37   VLPCQVEGEPPVSISWQRD-------RLALANESGVTLMPDGSLHLAALPSRRSLPSRAH 89
            +L C+  G PP +++W+R        RL     S       G L   ++      P    
Sbjct: 687  LLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP---- 742

Query: 90   EYHCVAQNRYGR-------LVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLI-QGV 141
             Y C A+N +G+       +V+  A  Q+AS +       ++ V  G      C++  G 
Sbjct: 743  -YVCEARNVFGKVQAEARLIVTGHAPPQIASSA------PTVRVLEGQPVSLPCIVLAGR 795

Query: 142  PEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQL 201
            P P   W  +G  L   + R ++   G LH+    Q   G Y CVA N A ++H +D +L
Sbjct: 796  PLPERHWLKDGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQH-RDVEL 853

Query: 202  TLSVGPLRLLQEPEILSGPQNLTLTVHQT-----AVLECIATSHPWPLVSWSRLDGRSIG 256
             + V P R+           + T T H T     A L C+A+  P P ++W++ +  ++ 
Sbjct: 854  VVQVPP-RI-----------HPTATHHITNEGVPASLPCVASGVPAPTITWTK-ETNALT 900

Query: 257  VEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVG 316
              G    ++   G L+I+  S Q +G YVC A    T    + +  L V  +P+      
Sbjct: 901  SRGPH-YNVSKEGTLLIAQPSAQDAGAYVCTAT--NTVGFSSQEMRLSVNTKPR------ 951

Query: 317  RVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFT 376
                            GSR     L +TA +                      G      
Sbjct: 952  ------------IHMNGSRNANVPLQVTAKA----------------------GEEVTLD 977

Query: 377  CVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQ 436
            C A+G P   + W K+ + + P  N      + +L LA V V D   Y+C A N  GS  
Sbjct: 978  CEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037

Query: 437  ASARLVVTGGP--EP---PRPQGPACHG------------SLYFCHSSVLGATPP 474
                L V G    +P   P P  PAC              S+  CH S+    PP
Sbjct: 1038 HRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLLQPTPRSVRLCHLSLRAPLPP 1092



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 110/465 (23%), Positives = 172/465 (36%), Gaps = 72/465 (15%)

Query: 35  PLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCV 94
           PL++ C V    P  +  +R    L  E       + S  +      R+  +    Y C 
Sbjct: 326 PLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEIL-----RASKAEEGTYECT 380

Query: 95  AQNRYGRLVSRRARVQLASLSRFHQ--HPESIEVERGGVACFQCLIQGVPEPSISWEHNG 152
           A +R G   + RA+ Q+       Q     ++ V  G  A   C + G    +++W  + 
Sbjct: 381 AVSRAG---TGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW 437

Query: 153 TALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQ 212
             L  +  RV  L    L I+ +  TD G Y+CVA N           +T +   L + +
Sbjct: 438 RVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG--------VTRASVWLLVRE 489

Query: 213 EPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLM 272
            P++     +   +      + C A+ +P P +SWSR    S  ++    + +   G L+
Sbjct: 490 APQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSR---ESQALQEDSRIHVDAQGTLI 546

Query: 273 ISDVSVQHSGVYVC-AANRPGTH----------------------VRRTAQGVLLVQGEP 309
           I  V+ + +G Y C A N  GT                       V    + VL+ +   
Sbjct: 547 IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASG 606

Query: 310 QGPNWVGRVLEHPSSLTGAWIWRGSRAGGKR-------------------LGLTAPSSML 350
             P    RV+ +   L       GS +G  R                   LG  +    L
Sbjct: 607 VPP---PRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQL 663

Query: 351 LPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKN-----GKVLSPGNNIRLT 405
                P+  + P+ ++   G SA+  C A G P   + W +      G  L  G   R  
Sbjct: 664 AVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSR 723

Query: 406 HNNS-TLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP 449
             +S  L    V+ ED+A Y C A N  G  QA ARL+VTG   P
Sbjct: 724 QPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 768



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 21/68 (30%), Positives = 30/68 (44%), Gaps = 2/68 (2%)

Query: 408 NSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEP--PRPQGPACHGSLYFCH 465
           NS+  +   S  +E  Y+C A +  G+ +A A++VVT  P    P P      G      
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420

Query: 466 SSVLGATP 473
             VLG  P
Sbjct: 421 CRVLGEAP 428


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score =  110 bits (275), Expect = 4e-24
 Identities = 113/429 (26%), Positives = 175/429 (40%), Gaps = 77/429 (17%)

Query: 33  EHPLVLPCQVEGEPPVSISWQRDRLALANESGVTL---MPDGSLHLAALPSRRSLPSRAH 89
           E  + L C+V+G P   I W+ +   +  ++G+     + +GSL    L +  +    A 
Sbjct: 43  EKKVKLNCEVKGNPKPHIRWKLNGTDV--DTGMDFRYSVVEGSL----LINNPNKTQDAG 96

Query: 90  EYHCVAQNRYGRLVSRRARVQLASLSRFHQHPES-IEVERGGVACFQCLIQGVP----EP 144
            Y C A N +G +VSR A++Q A L  F     S + V RG      C   G P    E 
Sbjct: 97  TYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLC---GPPPHSGEL 153

Query: 145 SISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRH---SQDAQL 201
           S +W  N       N R     +G L+I  V ++D+G Y CV  N   T H        L
Sbjct: 154 SYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTV-TNHKVLGPPTPL 212

Query: 202 TLSVGPLRLLQEPEI-LSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGI 260
            L    +    EP+I +  P+ +      T  LEC A  +P P + W R DG+ I  +  
Sbjct: 213 ILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKAR 272

Query: 261 QVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLE 320
           +       G L I +   + +G+Y C A    +  +  A+G L    +   PNW+ ++ +
Sbjct: 273 R---HKSNGILEIPNFQQEDAGLYECVAE--NSRGKNVARGQLTFYAQ---PNWIQKIND 324

Query: 321 HPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQ 380
                                         +   + E V W               C A 
Sbjct: 325 ------------------------------IHVAMEENVFW--------------ECKAN 340

Query: 381 GVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASAR 440
           G P+    WLKNG+ L   + I++     TL +  V++ D  +YQC+AEN  G   ++A 
Sbjct: 341 GRPKPTYKWLKNGEPLLTRDRIQI--EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAE 398

Query: 441 L-VVTGGPE 448
           L V+  GP+
Sbjct: 399 LSVIAVGPD 407



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 149/646 (23%), Positives = 251/646 (38%), Gaps = 100/646 (15%)

Query: 21  FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
           ++Q++ D     E  +   C+  G P  +  W ++   L     + +   G+L++  +  
Sbjct: 318 WIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQI-EQGTLNITIVNL 376

Query: 81  RRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRFHQH--PESIEVERGGVACFQCLI 138
                S A  Y C+A+N++G + S      +A    F +        V+ GG    +C  
Sbjct: 377 -----SDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKP 431

Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
           +  P+P  +W+  G  +   N R+T+   G L I +V+++D G+Y C+A N   T     
Sbjct: 432 KASPKPVYTWK-KGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGT----- 485

Query: 199 AQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIAT-SHPWPLV-SWS----RLDG 252
                S G L +     ++  P ++ +TV ++ VL C  T  H   +V +WS     +D 
Sbjct: 486 ---ASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDF 542

Query: 253 RSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHV-RRTAQGVLLVQGEPQG 311
              G    +V      G+LMI ++ ++H+G YVC      T V R +A   L+V+G P  
Sbjct: 543 DRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQ---TSVDRLSAAADLIVRGPPGP 599

Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPG- 370
           P  V   ++  +  T    WR        +     +  ++ A+ P  V W Q++S  P  
Sbjct: 600 PEAV--TIDEITDTTAQLSWRPGPDNHSPI-----TMYVIQARTPFSVGW-QAVSTVPEL 651

Query: 371 -SSAIFTCVAQGVP-----ESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIY 424
                FT    G+      E R V      V+  G   R +    T         +EA+ 
Sbjct: 652 IDGKTFTATVVGLNPWVEYEFRTV---AANVIGIGEPSRPSEKRRT---------EEALP 699

Query: 425 QCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLYFCH---SSVLGATPPSSRDIIG 481
           +    N +G   + + LV+T    P   Q     G +         +   T  +S D   
Sbjct: 700 EVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASR 759

Query: 482 YVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEG----------- 530
           YV     V   S  E++  +     E  FS   P T        YSAE            
Sbjct: 760 YVFRNESVHPFSPFEVKVGVFNNKGEGPFS---PTTV------VYSAEEEPTKPPASIFA 810

Query: 531 ---ASQDSAPIFASTMGSNLGEALNLPV-------------PLKACLSQCDLA---PEPA 571
              ++ D    +AS +  N G      V              ++   +Q        + +
Sbjct: 811 RSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGS 870

Query: 572 ALYDIKLQAFNGNGDGNSSARC-VSLRDVPLATPDGTV---STESK 613
            LY + ++A+N  G G SSA   V+ R  P + P G +   S++SK
Sbjct: 871 VLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSK 916



 Score = 36.6 bits (83), Expect = 0.075
 Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 4/83 (4%)

Query: 356 PEFVQWPQSLSKPPGSS---AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLM 412
           P F+Q P  +  P  S        C  +G P+  + W  NG  +  G + R +    +L+
Sbjct: 26  PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLL 85

Query: 413 LAGVS-VEDEAIYQCVAENSTGS 434
           +   +  +D   YQC A NS G+
Sbjct: 86  INNPNKTQDAGTYQCTATNSFGT 108


>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
           isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score =  107 bits (267), Expect = 3e-23
 Identities = 148/604 (24%), Positives = 221/604 (36%), Gaps = 105/604 (17%)

Query: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
           MGLL++LL G GCAA     F++E  D + V        CQ  G+P   ++W +    + 
Sbjct: 16  MGLLVVLLVG-GCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN 74

Query: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQL------ASL 114
           ++   T+  D S            P   + Y CVAQN  G +        L      +  
Sbjct: 75  SQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGF 134

Query: 115 SRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALN--TANHRVTLLPSGILHI 172
                 P+   VER   A   C   G P+P I+W  +   ++   +N R+  L SG L I
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQI 194

Query: 173 TSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAV 232
            S  +TD G Y CVA N A  R+S  A L + V  +     P     P +  +       
Sbjct: 195 ESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVA----PRFSILPMSHEIMPGGNVN 250

Query: 233 LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA---- 288
           + C+A   P P V W +      G E +   D +  G  ++    V+ S  Y C A    
Sbjct: 251 ITCVAVGSPMPYVKWMQ------GAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSL 304

Query: 289 ---------------NRPGTHV--RRTAQGVLLV--QGEPQGPNWVGRVLEHPS-SLTGA 328
                            PGT +    TA  + +    G P   ++   V+E+ S S  G 
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYY--VIEYKSKSQDGP 362

Query: 329 W-IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR- 386
           + I          +G  +P+S     +   +V    S+ + P S ++ T   +  P S  
Sbjct: 363 YQIKEDITTTRYSIGGLSPNS-----EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417

Query: 387 --------------LVWLK----NGKV--------LSP----GNNIRLTHNNSTLMLAGV 416
                         + W +    NG +        + P    GN  +   ++S L   G 
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477

Query: 417 SVEDEAI-YQCVAENSTGSNQASARLVVT---GGPEPPRPQGPACHGSLYFCHSSVLGAT 472
            +EDE    + +A  S G    S  + V    G P  P               S  L  +
Sbjct: 478 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET----SITLSWS 533

Query: 473 PPSSRDIIGYVL------HLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAY 526
           PP    II Y L      H R VG    P         T+ +V  +L+P T Y   L A 
Sbjct: 534 PPRQESIIKYELLFREGDHGREVGRTFDP---------TTSYVVEDLKPNTEYAFRLAAR 584

Query: 527 SAEG 530
           S +G
Sbjct: 585 SPQG 588



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 103/440 (23%), Positives = 163/440 (37%), Gaps = 78/440 (17%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSG---ILHI 172
           RF + P+      GGVA F C   G P+P ++W   G  +N+              +L I
Sbjct: 34  RFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRI 93

Query: 173 TSV-SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA 231
             + +  D   Y CVA N      +  A+LT+          P I  GPQ   +   +TA
Sbjct: 94  QPLRTPRDENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152

Query: 232 VLECIATSHPWPLVSW---------SRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSG 282
            + C A+ +P P ++W         S  +GR         +  L +G L I        G
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGR---------IKQLRSGALQIESSEETDQG 203

Query: 283 VYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLG 342
            Y C A      VR ++   L V+        V RV                        
Sbjct: 204 KYECVATN-SAGVRYSSPANLYVR--------VRRVA----------------------- 231

Query: 343 LTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNI 402
                        P F   P S    PG +   TCVA G P   + W++  + L+P +++
Sbjct: 232 -------------PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDM 278

Query: 403 RLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLY 462
            +  N    +L    V+D A Y CVA +S G  +A A++ V   P+ P       + +  
Sbjct: 279 PVGRN----VLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATS 334

Query: 463 FCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIH 522
              +   G   P S     YV+  +   +    +++E I+  T+ +    L P + Y I 
Sbjct: 335 ITITWDSGNPDPVSY----YVIEYKSKSQDGPYQIKEDIT--TTRYSIGGLSPNSEYEIW 388

Query: 523 LRAYSAEGASQDSAPIFAST 542
           + A ++ G    S  +   T
Sbjct: 389 VSAVNSIGQGPPSESVVTRT 408



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 7/129 (5%)

Query: 427 VAENSTGSNQASARLVV-TGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSRD---IIGY 482
           VA    G    S+ +VV T    P  P       +L      VL  +P   R    I GY
Sbjct: 684 VAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGY 743

Query: 483 VLH-LRPVG-EPSGP-ELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAEGASQDSAPIF 539
            +H +R  G E  GP  +++ +     E V +NL+P TAY+I + AY+ +G    S P  
Sbjct: 744 QVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKV 803

Query: 540 ASTMGSNLG 548
             T G+ LG
Sbjct: 804 VVTKGAVLG 812



 Score = 33.5 bits (75), Expect = 0.63
 Identities = 21/73 (28%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 473 PPSSRD--IIGYVLHLRPVG-EPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAYSAE 529
           PP + +  ++GY +  RP+G E   P+    I   T++ +   LE  T Y I   A++  
Sbjct: 630 PPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEV 689

Query: 530 GASQDSAPIFAST 542
           G   +S+P+   T
Sbjct: 690 GPGPESSPVVVRT 702


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
           isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score =  107 bits (267), Expect = 3e-23
 Identities = 148/604 (24%), Positives = 221/604 (36%), Gaps = 105/604 (17%)

Query: 1   MGLLLLLLPGWGCAAGSELAFVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALA 60
           MGLL++LL G GCAA     F++E  D + V        CQ  G+P   ++W +    + 
Sbjct: 16  MGLLVVLLVG-GCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVN 74

Query: 61  NESGVTLMPDGSLHLAALPSRRSLPSRAHEYHCVAQNRYGRLVSRRARVQL------ASL 114
           ++   T+  D S            P   + Y CVAQN  G +        L      +  
Sbjct: 75  SQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGF 134

Query: 115 SRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALN--TANHRVTLLPSGILHI 172
                 P+   VER   A   C   G P+P I+W  +   ++   +N R+  L SG L I
Sbjct: 135 PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQI 194

Query: 173 TSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAV 232
            S  +TD G Y CVA N A  R+S  A L + V  +     P     P +  +       
Sbjct: 195 ESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVA----PRFSILPMSHEIMPGGNVN 250

Query: 233 LECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAA---- 288
           + C+A   P P V W +      G E +   D +  G  ++    V+ S  Y C A    
Sbjct: 251 ITCVAVGSPMPYVKWMQ------GAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSL 304

Query: 289 ---------------NRPGTHV--RRTAQGVLLV--QGEPQGPNWVGRVLEHPS-SLTGA 328
                            PGT +    TA  + +    G P   ++   V+E+ S S  G 
Sbjct: 305 GVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYY--VIEYKSKSQDGP 362

Query: 329 W-IWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESR- 386
           + I          +G  +P+S     +   +V    S+ + P S ++ T   +  P S  
Sbjct: 363 YQIKEDITTTRYSIGGLSPNS-----EYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAP 417

Query: 387 --------------LVWLK----NGKV--------LSP----GNNIRLTHNNSTLMLAGV 416
                         + W +    NG +        + P    GN  +   ++S L   G 
Sbjct: 418 RNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGS 477

Query: 417 SVEDEAI-YQCVAENSTGSNQASARLVVT---GGPEPPRPQGPACHGSLYFCHSSVLGAT 472
            +EDE    + +A  S G    S  + V    G P  P               S  L  +
Sbjct: 478 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET----SITLSWS 533

Query: 473 PPSSRDIIGYVL------HLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIHLRAY 526
           PP    II Y L      H R VG    P         T+ +V  +L+P T Y   L A 
Sbjct: 534 PPRQESIIKYELLFREGDHGREVGRTFDP---------TTSYVVEDLKPNTEYAFRLAAR 584

Query: 527 SAEG 530
           S +G
Sbjct: 585 SPQG 588



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 103/440 (23%), Positives = 163/440 (37%), Gaps = 78/440 (17%)

Query: 116 RFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHNGTALNTANHRVTLLPSG---ILHI 172
           RF + P+      GGVA F C   G P+P ++W   G  +N+              +L I
Sbjct: 34  RFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRI 93

Query: 173 TSV-SQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTA 231
             + +  D   Y CVA N      +  A+LT+          P I  GPQ   +   +TA
Sbjct: 94  QPLRTPRDENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTA 152

Query: 232 VLECIATSHPWPLVSW---------SRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSG 282
            + C A+ +P P ++W         S  +GR         +  L +G L I        G
Sbjct: 153 TMLCAASGNPDPEITWFKDFLPVDPSASNGR---------IKQLRSGALQIESSEETDQG 203

Query: 283 VYVCAANRPGTHVRRTAQGVLLVQGEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLG 342
            Y C A      VR ++   L V+        V RV                        
Sbjct: 204 KYECVATN-SAGVRYSSPANLYVR--------VRRVA----------------------- 231

Query: 343 LTAPSSMLLPAQLPEFVQWPQSLSKPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNI 402
                        P F   P S    PG +   TCVA G P   + W++  + L+P +++
Sbjct: 232 -------------PRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDM 278

Query: 403 RLTHNNSTLMLAGVSVEDEAIYQCVAENSTGSNQASARLVVTGGPEPPRPQGPACHGSLY 462
            +  N    +L    V+D A Y CVA +S G  +A A++ V   P+ P       + +  
Sbjct: 279 PVGRN----VLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATS 334

Query: 463 FCHSSVLGATPPSSRDIIGYVLHLRPVGEPSGPELQEAISKGTSEHVFSNLEPATAYTIH 522
              +   G   P S     YV+  +   +    +++E I+  T+ +    L P + Y I 
Sbjct: 335 ITITWDSGNPDPVSY----YVIEYKSKSQDGPYQIKEDIT--TTRYSIGGLSPNSEYEIW 388

Query: 523 LRAYSAEGASQDSAPIFAST 542
           + A ++ G    S  +   T
Sbjct: 389 VSAVNSIGQGPPSESVVTRT 408


>gi|7657359 contactin 5 isoform long [Homo sapiens]
          Length = 1100

 Score =  107 bits (266), Expect = 5e-23
 Identities = 118/437 (27%), Positives = 176/437 (40%), Gaps = 76/437 (17%)

Query: 21  FVQELGDTVAVW---EHPLVLPCQVEGEPPVSISWQRDRLALANESGVTL-MPDGSLHLA 76
           FVQE  D +      E  + L C+V G P  S  W R+   +  ES     + DG+  + 
Sbjct: 101 FVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFII- 159

Query: 77  ALPSRRSLPSRAHE---YHCVAQNRYGRLVSRRARVQLASLSRFHQHPES-IEVERG-GV 131
                 S PS A +   Y C+A N  G ++SR A +Q A L  F     S + V  G GV
Sbjct: 160 ------SNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSVREGQGV 213

Query: 132 ACFQCLIQGVPEPSISWEHNGTALNTA--NHRVTLLPSGILHITSVSQTDMGTYRCVAWN 189
                     PE   SW  N      A  + R     +G L+I+ V  +D+G+Y C+  N
Sbjct: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273

Query: 190 VASTRH--SQDAQLTLSVGPLRLLQEPEI-LSGPQNLTLTVHQTAVLECIATSHPWPLVS 246
             +     S    LTL    +    EP+I +  P  +T     T  +EC A  +P P ++
Sbjct: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333

Query: 247 WSRLDGRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQ 306
           W +++G       ++    +    L I +V +  +G+Y C A    +  + + +G L V 
Sbjct: 334 WMKVNGYIPSKARLRKSQAV----LEIPNVQLDDAGIYECRAE--NSRGKNSFRGQLQVY 387

Query: 307 GEPQGPNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLS 366
                P+WV                       ++L  T   S                  
Sbjct: 388 ---TYPHWV-----------------------EKLNDTQLDS------------------ 403

Query: 367 KPPGSSAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQC 426
              GS   + C A G P     WLKNG  LSP + + +   N  LM+  V+  D  +YQC
Sbjct: 404 ---GSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV--NGVLMIHNVNQSDAGMYQC 458

Query: 427 VAENSTGSNQASARLVV 443
           +AEN  G+  ASA L +
Sbjct: 459 LAENKYGAIYASAELKI 475



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 130/556 (23%), Positives = 220/556 (39%), Gaps = 80/556 (14%)

Query: 21  FVQELGDTVAVWEHPLVLPCQVEGEPPVSISWQRDRLALANESGVTLMPDGSLHLAALPS 80
           +V++L DT      PL   C+  G+P  +  W ++ + L+ +S V ++ +G L +  +  
Sbjct: 392 WVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV-NGVLMIHNVNQ 450

Query: 81  RRSLPSRAHEYHCVAQNRYGRLVSRRARVQLASLSRF--HQHPESIEVERGGVACFQCLI 138
                S A  Y C+A+N+YG + +      LAS   F  +Q  ++I V +      +C  
Sbjct: 451 -----SDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQEVVIECKP 505

Query: 139 QGVPEPSISWEHNGTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQD 198
           QG P+P+ISW+    A+   N R+ +LP G L I + S++D G Y C   NV  +     
Sbjct: 506 QGSPKPTISWKKGDRAVRE-NKRIAILPDGSLRILNASKSDEGKYVCRGENVFGSAE--- 561

Query: 199 AQLTLSVGPLRLLQEPEILSGPQNLTLTVHQTAVLECIA-------TSHPWPLVSWSRLD 251
                 +  L + +   I   P+   LTV ++ VL C A        +  W L     +D
Sbjct: 562 -----IIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTL-KGQPID 615

Query: 252 GRSIGVEGIQVLDILDTGNLMISDVSVQHSGVYVCAANRPGTHVRRTAQGVLLVQGEPQG 311
               G     +     + +LMI ++ + H+G Y C        V   A+  LLV+G P  
Sbjct: 616 FEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE--LLVRGPPGP 673

Query: 312 PNWVGRVLEHPSSLTGAWIWRGSRAGGKRLGLTAPSSMLLPAQLPEFVQWPQSLSKPPGS 371
           P  V  ++E  +  T    W  +      +     SS  L A+ P  + W          
Sbjct: 674 PGIV--IVEEITESTATLSWSPAADNHSPI-----SSYNLQARSPFSLGWQ--------- 717

Query: 372 SAIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLMLAGVSVEDEAIYQCVAEN- 430
                   + VPE                   +T +  + M   ++   E  ++ VA N 
Sbjct: 718 ------TVKTVPEI------------------ITGDMESAMAVDLNPWVEYEFRVVATNP 753

Query: 431 -STGSNQASARLVVTGGPEPPRPQGPACHGSLYFCHSSVLGATPPSSR----DIIGYVLH 485
             TG     +R++ T     P+       G     H  V+   P S      +  GY++ 
Sbjct: 754 IGTGDPSTPSRMIRT-NEAVPKTAPTNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVA 812

Query: 486 LRPVGEPSGPELQEAISKGTSEHVF--SNLEPATAYTIHLRAYSAEGASQDSAPIFASTM 543
            RP G     E +   S   S+ ++   ++ P T + + +  Y+ +G    S  +    +
Sbjct: 813 FRPNGTRGWKE-KMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDGPFSQIV---VI 868

Query: 544 GSNLGEALNLPVPLKA 559
            S  GE    P  +KA
Sbjct: 869 CSAEGEPSAAPTDVKA 884



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 64/255 (25%), Positives = 112/255 (43%), Gaps = 29/255 (11%)

Query: 38  LPCQVEGEPPVSISWQR------DRLALANESGVTLMPDGSLHLAALPSRRSLPSRAHEY 91
           + C   G P  +I+W +       +  L     V  +P+  L  A +            Y
Sbjct: 320 MECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGI------------Y 367

Query: 92  HCVAQNRYGRLVSRRARVQLASLSRFHQHPESIEVERGGVACFQCLIQGVPEPSISWEHN 151
            C A+N  G+  S R ++Q+ +   + +     +++ G    ++C   G P P+  W  N
Sbjct: 368 ECRAENSRGKN-SFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKN 426

Query: 152 GTALNTANHRVTLLPSGILHITSVSQTDMGTYRCVAWNVASTRHSQDAQLTLSVGPLRLL 211
           G  L+  + RV ++ +G+L I +V+Q+D G Y+C+A N     ++      L+  P   L
Sbjct: 427 GVPLSPQS-RVEMV-NGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFAL 484

Query: 212 QEPEILSGPQNLTLTVHQTAVLECIATSHPWPLVSWSRLDGRSIGVEGIQVLDILDTGNL 271
            + +     + + +T  Q  V+EC     P P +SW + D     V   + + IL  G+L
Sbjct: 485 NQLK-----KTIIVTKDQEVVIECKPQGSPKPTISWKKGDR---AVRENKRIAILPDGSL 536

Query: 272 MISDVSVQHSGVYVC 286
            I + S    G YVC
Sbjct: 537 RILNASKSDEGKYVC 551



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 25/83 (30%), Positives = 39/83 (46%), Gaps = 4/83 (4%)

Query: 356 PEFVQWPQSLSKPPGSS---AIFTCVAQGVPESRLVWLKNGKVLSPGNNIRLTHNNSTLM 412
           P FVQ P  +  P  S        C  +G P     WL+NG  +   ++ R +  + T +
Sbjct: 99  PVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFI 158

Query: 413 LAGVS-VEDEAIYQCVAENSTGS 434
           ++  S  +D   YQC+A N+ GS
Sbjct: 159 ISNPSEAKDSGHYQCLATNTVGS 181


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,422,497
Number of Sequences: 37866
Number of extensions: 1518531
Number of successful extensions: 10172
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 258
Number of HSP's successfully gapped in prelim test: 183
Number of HSP's that attempted gapping in prelim test: 4559
Number of HSP's gapped (non-prelim): 3371
length of query: 654
length of database: 18,247,518
effective HSP length: 109
effective length of query: 545
effective length of database: 14,120,124
effective search space: 7695467580
effective search space used: 7695467580
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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