Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 117414137
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
(2400 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 4820 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 215 5e-55
gi|5454016 retinitis pigmentosa RP1 protein [Homo sapiens] 172 3e-42
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 130 2e-29
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 128 6e-29
gi|27894378 chloride intracellular channel 6 [Homo sapiens] 124 1e-27
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 122 3e-27
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 122 3e-27
gi|222537747 hypothetical protein LOC342979 [Homo sapiens] 119 4e-26
gi|83921609 hypothetical protein LOC127254 [Homo sapiens] 116 2e-25
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 111 7e-24
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 109 3e-23
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 109 3e-23
gi|24415404 MDN1, midasin homolog [Homo sapiens] 106 2e-22
gi|119220598 apolipoprotein B48 receptor [Homo sapiens] 105 4e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 100 1e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 100 1e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 100 1e-20
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 100 1e-20
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 100 1e-20
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 100 1e-20
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 100 1e-20
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 100 1e-20
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 100 2e-20
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 100 2e-20
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 99 4e-20
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 99 4e-20
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 97 2e-19
gi|38176300 nestin [Homo sapiens] 96 3e-19
gi|217330641 IWS1 homolog [Homo sapiens] 94 2e-18
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 4820 bits (12503), Expect = 0.0
Identities = 2400/2400 (100%), Positives = 2400/2400 (100%)
Query: 1 MNSTPRNAQAPSHRECFLPSVARTPSVTKVTPAKKITFLKRGDPRFAGVRLAVHQRAFKT 60
MNSTPRNAQAPSHRECFLPSVARTPSVTKVTPAKKITFLKRGDPRFAGVRLAVHQRAFKT
Sbjct: 1 MNSTPRNAQAPSHRECFLPSVARTPSVTKVTPAKKITFLKRGDPRFAGVRLAVHQRAFKT 60
Query: 61 FSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCYLCSDKKPPKTPSGPGRPQ 120
FSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCYLCSDKKPPKTPSGPGRPQ
Sbjct: 61 FSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCYLCSDKKPPKTPSGPGRPQ 120
Query: 121 ERNPTAQQLRDVEGQREAPGTSSSRKSLKTPRRILLIKNMDPRLQQTVVLSHRNTRNLAA 180
ERNPTAQQLRDVEGQREAPGTSSSRKSLKTPRRILLIKNMDPRLQQTVVLSHRNTRNLAA
Sbjct: 121 ERNPTAQQLRDVEGQREAPGTSSSRKSLKTPRRILLIKNMDPRLQQTVVLSHRNTRNLAA 180
Query: 181 FLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVCAGHEAFRTPAMKNARRSEAET 240
FLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVCAGHEAFRTPAMKNARRSEAET
Sbjct: 181 FLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVCAGHEAFRTPAMKNARRSEAET 240
Query: 241 LSGLTSRNKNGSWGPKTKPSVIHSRSPPGSTPRLPERPGPSNPPVGPAPGRHPQDTPAQS 300
LSGLTSRNKNGSWGPKTKPSVIHSRSPPGSTPRLPERPGPSNPPVGPAPGRHPQDTPAQS
Sbjct: 241 LSGLTSRNKNGSWGPKTKPSVIHSRSPPGSTPRLPERPGPSNPPVGPAPGRHPQDTPAQS 300
Query: 301 GPLVAGDDMKKKVRMNEDGSLSVEMKVRFHLVGEDTLLWSRRMGRASALTAASGEDPVLG 360
GPLVAGDDMKKKVRMNEDGSLSVEMKVRFHLVGEDTLLWSRRMGRASALTAASGEDPVLG
Sbjct: 301 GPLVAGDDMKKKVRMNEDGSLSVEMKVRFHLVGEDTLLWSRRMGRASALTAASGEDPVLG 360
Query: 361 EVDPLCCVWEGYPWGFSEPGVWGPRPCRVGCREVFGRGGQPGPKYEIWTNPLHASQGERV 420
EVDPLCCVWEGYPWGFSEPGVWGPRPCRVGCREVFGRGGQPGPKYEIWTNPLHASQGERV
Sbjct: 361 EVDPLCCVWEGYPWGFSEPGVWGPRPCRVGCREVFGRGGQPGPKYEIWTNPLHASQGERV 420
Query: 421 AARKRWGLAQHVRCSGLWGHGTAGRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGV 480
AARKRWGLAQHVRCSGLWGHGTAGRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGV
Sbjct: 421 AARKRWGLAQHVRCSGLWGHGTAGRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGV 480
Query: 481 DSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTG 540
DSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTG
Sbjct: 481 DSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTG 540
Query: 541 SHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQ 600
SHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQ
Sbjct: 541 SHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQ 600
Query: 601 ATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVA 660
ATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVA
Sbjct: 601 ATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVA 660
Query: 661 PRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLR 720
PRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLR
Sbjct: 661 PRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLR 720
Query: 721 PPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHT 780
PPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHT
Sbjct: 721 PPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHT 780
Query: 781 SDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRG 840
SDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRG
Sbjct: 781 SDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRG 840
Query: 841 PSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPS 900
PSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPS
Sbjct: 841 PSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPS 900
Query: 901 PGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREW 960
PGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREW
Sbjct: 901 PGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREW 960
Query: 961 LDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQ 1020
LDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQ
Sbjct: 961 LDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQ 1020
Query: 1021 DPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVS 1080
DPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVS
Sbjct: 1021 DPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVS 1080
Query: 1081 ASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVR 1140
ASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVR
Sbjct: 1081 ASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVR 1140
Query: 1141 FKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSG 1200
FKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSG
Sbjct: 1141 FKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSG 1200
Query: 1201 VDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPT 1260
VDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPT
Sbjct: 1201 VDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPT 1260
Query: 1261 FLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
FLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV
Sbjct: 1261 FLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380
QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG
Sbjct: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG 1380
Query: 1381 PEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAE 1440
PEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAE
Sbjct: 1381 PEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAE 1440
Query: 1441 PCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAA 1500
PCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAA
Sbjct: 1441 PCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAA 1500
Query: 1501 ERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAEL 1560
ERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAEL
Sbjct: 1501 ERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAEL 1560
Query: 1561 QQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFS 1620
QQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFS
Sbjct: 1561 QQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFS 1620
Query: 1621 ERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATR 1680
ERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATR
Sbjct: 1621 ERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATR 1680
Query: 1681 GPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGV 1740
GPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGV
Sbjct: 1681 GPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGV 1740
Query: 1741 DEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISER 1800
DEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISER
Sbjct: 1741 DEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISER 1800
Query: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860
GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA
Sbjct: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860
Query: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETE 1920
QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETE
Sbjct: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETE 1920
Query: 1921 SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980
SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL
Sbjct: 1921 SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980
Query: 1981 EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040
EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE
Sbjct: 1981 EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040
Query: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG
Sbjct: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
Query: 2101 VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE 2160
VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE
Sbjct: 2101 VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE 2160
Query: 2161 SEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEE 2220
SEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEE
Sbjct: 2161 SEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEE 2220
Query: 2221 AQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPP 2280
AQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPP
Sbjct: 2221 AQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPP 2280
Query: 2281 PSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKA 2340
PSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKA
Sbjct: 2281 PSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKA 2340
Query: 2341 TRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQDDLDF 2400
TRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQDDLDF
Sbjct: 2341 TRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQDDLDF 2400
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 215 bits (547), Expect = 5e-55
Identities = 179/547 (32%), Positives = 262/547 (47%), Gaps = 61/547 (11%)
Query: 1724 QGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSA 1783
+GAE G G+ + E E E + +++ + K + ++ + K SE A
Sbjct: 591 EGAEDSKGNGIEE----QEVEANEENVKVHGGRKEKT-----EILSDDLTDKAEVSEGKA 641
Query: 1784 GSELGEAEQ----EGEGISERGETGGQGSGHEDNLQGEAAAG-GDQD---PGQSDGAEGI 1835
S +GEAE G+G E G +G + E+ +GE G G+ + G+ + AE
Sbjct: 642 KS-VGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
Query: 1836 EAPEAEGEAQPESEGVEAPEAE--------GDAQEAEGEAQP-ESEDVEAPEAEGEAQPE 1886
E + +GE Q + E + + E G+ + EGE + + E+ E E EG+ + E
Sbjct: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE 760
Query: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
E+VE + E + + E E + E + + E ETEG E + EG E + E
Sbjct: 761 GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGE-- 818
Query: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQ-EAEGEAQPESEDVEAPEA 2005
+E +G+ + E E E + EEE + E E+ E E E E + E EGE E+ E E
Sbjct: 819 VEEGKGEREEEEE--EGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEG 876
Query: 2006 EGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQ 2065
EGE +E E E + E +G + + EGE +E EGE ++ EG+ + E +G E E E E +
Sbjct: 877 EGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEG-EGEGEEE 935
Query: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125
E EGE ++ EGE E + + +E EGE + E EG EGE ++ EG E E EGE
Sbjct: 936 EGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG------EGEGEEGEG-EGEEEEGEG 988
Query: 2126 QPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEA 2185
+ E E EGE + E EG EGE + E EG E +E E E E+EG E E
Sbjct: 989 EGEEE-------EGEEEGEEEG------EGEEEGEGEGEEEEEGEVEG--EVEGEEG-EG 1032
Query: 2186 EGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGET 2245
EGE + E E E EGE + EEE + E + ET E E E Q E +
Sbjct: 1033 EGEEEEGEEEGEEREKEGEGEENRR-----NREEEEEEEGKYQETGEEENERQDGEEYKK 1087
Query: 2246 QGEKKGS 2252
+ KGS
Sbjct: 1088 VSKIKGS 1094
Score = 209 bits (533), Expect = 2e-53
Identities = 176/543 (32%), Positives = 256/543 (47%), Gaps = 61/543 (11%)
Query: 1764 EGDAMAQEREGKTHNSETSAG--------------SELGEAEQEGEGISERGETGGQGSG 1809
E + M++ +EGK S G E E +E EG + G +
Sbjct: 546 EYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQE 605
Query: 1810 HEDNLQGEAAAGGDQDPGQ--SDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEA 1867
E N + GG ++ + SD +A +EG+A+ E + PE GD EG +
Sbjct: 606 VEANEENVKVHGGRKEKTEILSDDLTD-KAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSS 664
Query: 1868 ------QPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETES 1921
E E E + GE + E E AE E + +G E + E+E + E
Sbjct: 665 GAEHWQDEEREKGEKDKGRGEMERPGEG-EKELAEKEEWKKRDGEEQEQKEREQGHQKER 723
Query: 1922 VEALETEGEDEP-ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980
+ +E GE+E E E E EE +E EG+ + E E +E + +EE + + E+
Sbjct: 724 NQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGK 783
Query: 1981 EVEVETQEAEGEAQPESEDVEAPEAE-------GEMQEAEEEAQPESDGVEAQPKSEGEE 2033
E + E + +GE + E + E E GE++E + E + E + E + + E E
Sbjct: 784 EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE--EGEGEEEEGE 841
Query: 2034 AQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE-DVDAQEAEG 2092
+E EGE ++ EG+ + E +G E E EEE +E EGE +E EGE E E + + +E EG
Sbjct: 842 GEEEEGEGEEEEGEGKGEEEGEEG-EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 900
Query: 2093 EAQPESEGVEAPEAEGEAQKAEG---IEAPETEGEAQPESEGIEAPEAEGEAQPESEGVE 2149
E + E EG E EGE ++ EG E E EGE + E E + EGE + E E
Sbjct: 901 EGEGEEEG----EGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWE 956
Query: 2150 AQDAEGEAQPESEGI-EAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPE 2208
++ EGE + E EG E +E E E + E E EGE + E EG E E EGE + E
Sbjct: 957 GEEEEGEGEGEEEGEGEGEEGEGEGEEE-------EGEGEGE-EEEGEEEGEEEGEGEEE 1008
Query: 2209 LEGVEAPEAEEEAQPEPEG-VETPEAEGEAQPESEGETQG---EKKGSPQVSLGDGQSEE 2264
EG E EEE + E EG VE E EGE + E EGE +G EK+G + + + + EE
Sbjct: 1009 GEG----EGEEEEEGEVEGEVEGEEGEGEGE-EEEGEEEGEEREKEGEGEENRRNREEEE 1063
Query: 2265 ASE 2267
E
Sbjct: 1064 EEE 1066
Score = 191 bits (486), Expect = 6e-48
Identities = 162/494 (32%), Positives = 226/494 (45%), Gaps = 51/494 (10%)
Query: 1704 EAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEA 1763
+ AEV+ GK ++V AE G +G G E+G +D++ + GE
Sbjct: 632 DKAEVSEGKA-------KSVGEAEDG-----PEGRGDGTCEEGSSGAEHWQDEEREKGEK 679
Query: 1764 EGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGD 1823
+ ER G+ EL E E+ + E E + GH+ E GG+
Sbjct: 680 DKGRGEMERPGEGEK-------ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGE 732
Query: 1824 QDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESE--DVEAPEAEG 1881
++ G+ + EG E E E + + EG E E EG+ ++ EGE + E E E EG
Sbjct: 733 EEHGEGEEEEGDREEEEEKEGEGKEEG-EGEEVEGEREKEEGERKKEERAGKEEKGEEEG 791
Query: 1882 E-AQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEA 1940
+ + E E+ E E E E EG E E + E + E E E E EGE E E E
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEE 851
Query: 1941 QEAEEAAQEA--EGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE 1998
+E E +E EG+ + E E E + EEE + E E E E E E +E EGE + E E
Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGE--EEGEGEGEEEEGEGEGEEEGE 909
Query: 1999 DVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGD---AQPESDGV 2055
E E EGE + EE + E +G E + + EGE+ EGE ++ EG+ + E +G
Sbjct: 910 G-EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG---EGEGEEEEGEWEGEEEEGEGE 965
Query: 2056 EAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQ-EAEGEAQPESEGVEAPEAEGEAQKAE 2114
E E E +E EGE +E EGE E E+ + + E EGE + E EG EGE
Sbjct: 966 GEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEG------EGE----- 1014
Query: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
E EGE + E EG E E EGE + E E ++ EGE + E +E EE
Sbjct: 1015 ----EEEEGEVEGEVEG-EEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKY 1069
Query: 2175 PELEGVEAPEAEGE 2188
E E +GE
Sbjct: 1070 QETGEEENERQDGE 1083
Score = 177 bits (450), Expect = 8e-44
Identities = 153/529 (28%), Positives = 233/529 (44%), Gaps = 49/529 (9%)
Query: 1646 QLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEA 1705
++ EE EG E ++V + R KE ++ + E ++G+A
Sbjct: 585 EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGR---KEKTEILSDDLTDKAEVSEGKA 641
Query: 1706 AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNR--DKDPKLGEA 1763
V G+ P EG G Q ++GE +G + R + + +L E
Sbjct: 642 KSV--GEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK 699
Query: 1764 E------GDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERG----ETGGQGSGHEDN 1813
E G+ Q+ + H E + E G E+ GEG E G E +G G E+
Sbjct: 700 EEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG 759
Query: 1814 LQGEAAAG---------------GDQDPGQSDGAEGI-EAPEAEGEAQPESEGVEAPEAE 1857
+GE G G ++ G+ +G +G E E EG + + EG E
Sbjct: 760 -EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG-- 816
Query: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQP 1917
G+ +E +GE + E E+ E E EGE + E + E E E + + E E E E +E +
Sbjct: 817 GEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEG 876
Query: 1918 ETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV 1977
E E E E EGE+E E EG E + E +E EG+ + E + +E EE + E E+
Sbjct: 877 EGEEEEG-EGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEE 935
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQ-E 2036
E E E ++ EGE + E E EGE +E E E + E +G + + EGEE + E
Sbjct: 936 EG---EGEGEDGEGEGEEEEG-----EWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE 987
Query: 2037 VEGETQKTEGDAQPESDGVEAPEAE---EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
EGE ++ E + + E +G E E E EE E EGEV+ EGE E E+ + + E E
Sbjct: 988 GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEERE 1047
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQ 2142
+ E E E E ++ + E E E E Q E + + +G +
Sbjct: 1048 KEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVK 1096
Score = 148 bits (374), Expect = 6e-35
Identities = 131/412 (31%), Positives = 194/412 (47%), Gaps = 52/412 (12%)
Query: 1698 GEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDK- 1756
GE +GE E G+ + + + +G E G QG G +E +G G ++ +
Sbjct: 761 GEEVEGER-EKEEGERKKEERAGKEEKGEEEG-----DQGEGEEEETEGRGEEKEEGGEV 814
Query: 1757 -DPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQE-GEGISERGETGGQGSGHEDNL 1814
++ E +G+ +E EG+ E E GE E+E GEG E E G +G G E+
Sbjct: 815 EGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGE--EEGEEGEGEEEGE 872
Query: 1815 QGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQP-ESEGVEAPEAEGDAQEAEGEAQPESED 1873
+GE G+++ G+ EG E E EGE + E EG E E EG+ +E EG+ + E E
Sbjct: 873 EGEGE--GEEEEGEG---EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE- 926
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
EGE + E E E + E E E E+E + E E E E EGE+E
Sbjct: 927 ------EGEGEGEEE---------EGEGEGEDGEGEGEEEEGEWEGEEEEG-EGEGEEEG 970
Query: 1934 ESEGAEAQ-EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
E EG E + E EE E EG E +E EEE + E E E E E E +E EGE
Sbjct: 971 EGEGEEGEGEGEEEEGEGEG---------EEEEGEEEGEEEGEGEEEGEGEGE-EEEEGE 1020
Query: 1993 AQPESEDVEAPEAEGEMQEAEEEAQP-ESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
+ E E E E EGE +E EEE + E +G + + EE +E EG+ Q+T +
Sbjct: 1021 VEGEVEGEEG-EGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENER 1079
Query: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEA 2103
DG E ++ + +G V+ + + + + + V + G+ Q V++
Sbjct: 1080 QDG----EEYKKVSKIKGSVKYGKHKTY-QKKSVTNTQGNGKEQRSKMPVQS 1126
Score = 141 bits (356), Expect = 7e-33
Identities = 143/522 (27%), Positives = 215/522 (41%), Gaps = 42/522 (8%)
Query: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
+E+ ++ E E E+ EG + + T+ +E ++E E E +E
Sbjct: 539 TENDDSDEYE-EMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEE-----VEIPEEKEG 592
Query: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV--ETQEAEGEAQPESEDVEAPE 2004
A++++G E EV ++E + E E L ++ + + +EG+A+ E + PE
Sbjct: 593 AEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPE 652
Query: 2005 AEG-----EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059
G E E Q E + K GE + EGE + E + + DG E +
Sbjct: 653 GRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQ 712
Query: 2060 AEEEA---QEAEGEVQEAEGEAHPESEDVDA-----QEAEGEAQPESEGVEAPEAEGEAQ 2111
E E +E E++E E H E E+ + +E EGE + E EG E EGE +
Sbjct: 713 KEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEG---EEVEGERE 769
Query: 2112 KAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171
K EG E + E + E E + EGE + E+EG + EG E EG E +E +
Sbjct: 770 KEEG-ERKKEERAGKEEKGEEEGDQGEGEEE-ETEGRGEEKEEGG---EVEGGEVEEGKG 824
Query: 2172 EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP 2231
E + E E E E EGE + E EG E E EGE + E EG EE + E EG E
Sbjct: 825 EREEEEEEGEGEEEEGEGE-EEEG-EGEEEEGEGKGEEEG-------EEGEGEEEG-EEG 874
Query: 2232 EAEGEAQP-ESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQ 2290
E EGE + E EGE +GE +G + G+G+ E E E + G +
Sbjct: 875 EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEE 934
Query: 2291 RPGSQTG-PSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESST 2349
G G W+ + E G+ G E + E
Sbjct: 935 EEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEE 994
Query: 2350 SEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRAD 2391
E+E G E+G EG + +E + G + E G +
Sbjct: 995 GEEEGEEEG-EGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGE 1035
Score = 105 bits (262), Expect = 5e-22
Identities = 101/326 (30%), Positives = 128/326 (39%), Gaps = 93/326 (28%)
Query: 1634 EDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQIL 1693
E E G + GEE EGEE
Sbjct: 848 EGEEEEGEGKGEEEGEEGEGEE-------------------------------------- 869
Query: 1694 QRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLN 1753
GE +GE E E G G G +G G E E+GEG
Sbjct: 870 ---EGEEGEGEGEE-------------------EEGEGEGEEEGEGEGEEEEGEGE---- 903
Query: 1754 RDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDN 1813
GE EG+ +E EG+ G E GE E EGEG E GE G ++
Sbjct: 904 -------GEEEGEGEGEEEEGE------GKGEEEGE-EGEGEGEEEEGE------GEGED 943
Query: 1814 LQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESED 1873
+GE G+++ G+ +G E E E EGE + E EG E E EG+ +E EGE + E E
Sbjct: 944 GEGE----GEEEEGEWEGEE--EEGEGEGEEEGEGEGEEG-EGEGEEEEGEGEGE-EEEG 995
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
E E EGE + E E E E EV+ E EG E E E E + E E E EGE E
Sbjct: 996 EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEG-EGEGEEEEGEEEGEEREKEGEGEE 1054
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESE 1959
E +E EE + G+ + E +
Sbjct: 1055 NRRNREEEEEEEGKYQETGEEENERQ 1080
Score = 92.0 bits (227), Expect = 6e-18
Identities = 82/241 (34%), Positives = 109/241 (45%), Gaps = 16/241 (6%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEV---QLEETKEGTEGEGLQEEAVQLEETKTEE 1329
E+E E + EE+ E+ E +EE + EE E EGEG +EE E E
Sbjct: 888 EEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGE 947
Query: 1330 GLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG-PEGGLQGE 1388
G +EEG E +E EGEG+ EEE + E EE GEG +EEG E +EG EG +GE
Sbjct: 948 GEEEEGEW--EGEEEEGEGEGEEEGE-GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGE 1004
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTE 1448
EEG E EEG V G E +G+G E++ +EE R E
Sbjct: 1005 GEEEGEGEGEEEEEGEVEG----EVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNRE 1060
Query: 1449 EPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQP----TQGAAERSS 1504
E E ET +ERQ G + + + K G+ G+ T + TQG +
Sbjct: 1061 EEEEEEGKYQETGEEENERQDGEEYKK-VSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQR 1119
Query: 1505 S 1505
S
Sbjct: 1120 S 1120
Score = 90.1 bits (222), Expect = 2e-17
Identities = 128/520 (24%), Positives = 201/520 (38%), Gaps = 93/520 (17%)
Query: 1899 VQPESEGAEAPEAEKEAQPETES-VEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPE 1957
+QPE E KEA+ + S VE+L + + E++ + + Q Q +
Sbjct: 466 MQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQKK 525
Query: 1958 SEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQ---EAEE 2014
+ I + ++ A E++D + E E +E + Q S+ + + ++ + E
Sbjct: 526 QQTI-GELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEV 584
Query: 2015 EAQPESDGVEAQPKSEGEEAQEVE----------GETQKTEGDAQPESDGVEAPEAE--- 2061
E E +G E K G E QEVE G +KTE + +D E E +
Sbjct: 585 EIPEEKEGAE-DSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKS 643
Query: 2062 ----EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE 2117
E+ E G+ EG + E D + +GE +E P EGE + AE E
Sbjct: 644 VGEAEDGPEGRGDGTCEEGSSGAEHWQ-DEEREKGEKDKGRGEMERP-GEGEKELAEKEE 701
Query: 2118 APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL 2177
+ +GE Q + E + + E + E EG E + EGE E EG +E E+E + +
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEME-EGGEEEHGEGE---EEEGDREEEEEKEGEGKE 757
Query: 2178 EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEA 2237
EG E E EGE + E EGE + E + + EEE + EG E E EG
Sbjct: 758 EG-EGEEVEGEREKE---------EGERKKEERAGKEEKGEEEGD-QGEG-EEEETEGRG 805
Query: 2238 QPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTG 2297
+ + EG GE +G +V G G+ EE E
Sbjct: 806 EEKEEG---GEVEGG-EVEEGKGEREEEEEE----------------------------- 832
Query: 2298 PSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPL 2357
G +++ E + G+ + + G E E E+ E
Sbjct: 833 ---------GEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE--------EGEGEEEGEEGE 875
Query: 2358 GSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFGQDD 2397
G E+G EG + E + G E G +G G+ +
Sbjct: 876 GEGEEEEGEGEGEE--EGEGEGEEEEGEGEGEEEGEGEGE 913
Score = 88.6 bits (218), Expect = 7e-17
Identities = 81/254 (31%), Positives = 113/254 (44%), Gaps = 38/254 (14%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E+E +R+ EE++ E+ EEV+ E KE EGE +EE EE EEG Q
Sbjct: 740 EEEGDREEEEEKEGEGKEE----GEGEEVEGEREKE--EGERKKEERAGKEEKGEEEGDQ 793
Query: 1333 ---------------EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEV 1377
EEG ++E + EG+G++EEE + E EE GEG +EEG EE
Sbjct: 794 GEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
Query: 1378 KE--GPEGGLQGEALEEGLKEEGLPE------EGSVHGQELSEASSPDGKGSQEDDPVQE 1429
E G E G +GE EEG + EG E EG G+ E +G+G +E + E
Sbjct: 854 GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGE 913
Query: 1430 EE--AGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMG 1487
EE G+ E EG EE E E + E + + E G + G
Sbjct: 914 EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGE-------G 966
Query: 1488 QEHTQAQPTQGAAE 1501
+E + + +G E
Sbjct: 967 EEEGEGEGEEGEGE 980
Score = 77.4 bits (189), Expect = 2e-13
Identities = 76/225 (33%), Positives = 96/225 (42%), Gaps = 45/225 (20%)
Query: 1270 ATNEDEAERDSEEQRASSNLE--QLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKT 1327
A E+ +RD EEQ + Q N EE EE EG E EG +EE + E
Sbjct: 697 AEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGK 756
Query: 1328 EEGL---------------------------QEEGVQLE-ETKETEGEGQQEEE-AQLE- 1357
EEG +EEG Q E E +ETEG G+++EE ++E
Sbjct: 757 EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEG 816
Query: 1358 ----------EIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHG 1407
E EE GEG +EEG EE EG E +G+ EEG EEG EE G
Sbjct: 817 GEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG--EEGEGEEEGEEG 874
Query: 1408 QELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTE 1452
+ E +G+G +E + EEE G E EG EE E
Sbjct: 875 EGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG-EGEGEEEEGE 918
Score = 75.1 bits (183), Expect = 8e-13
Identities = 79/262 (30%), Positives = 112/262 (42%), Gaps = 35/262 (13%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEET---KTEE 1329
E+E E EE+ +E EE + E +E EGEG +EE EE + EE
Sbjct: 798 EEETEGRGEEKEEGGEVE----GGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEE 853
Query: 1330 GL---QEEGVQLE----------ETKETEGEGQQEEEAQLEEIEETG-GEGLQE---EGV 1372
G +EEG + E E +E EGEG+ EEE + E EE G GEG +E EG
Sbjct: 854 GEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGE 913
Query: 1373 QLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELS---EASSPDGKGSQEDDPVQE 1429
+ E +G E G +GE E + EG E+G G+E E +G+G E++ E
Sbjct: 914 EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGE 973
Query: 1430 EEAGRASASAEPCPAEGTEEPTEPPSHL----SETDPSASERQSGSQLEPGLE----KPP 1481
E G E EG EE E E E + ++E +E +
Sbjct: 974 GEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGE 1033
Query: 1482 GATMMGQEHTQAQPTQGAAERS 1503
G G+E + + +G E +
Sbjct: 1034 GEEEEGEEEGEEREKEGEGEEN 1055
Score = 62.0 bits (149), Expect = 7e-09
Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 9/240 (3%)
Query: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEE--TKT 1327
A + EAE D E R E+ + + + E E +G G E + E+ +
Sbjct: 641 AKSVGEAE-DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEK 699
Query: 1328 EEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQG 1387
EE + +G + E+ + +G ++ + E EE GEG +EEG + EE ++ EG +G
Sbjct: 700 EEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEG 759
Query: 1388 EALE---EGLKEEG-LPEEGSVHGQELSEASSPDGKGSQEDDP--VQEEEAGRASASAEP 1441
E E E KEEG +E +E E G+G +E+ +E+E G E
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
Query: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAE 1501
+G E E E + E + + E G K G+ + + +G E
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE 879
Score = 56.2 bits (134), Expect = 4e-07
Identities = 58/232 (25%), Positives = 105/232 (45%), Gaps = 15/232 (6%)
Query: 1278 RDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEG---LQEEAVQLEETKTEEGLQEE 1334
R + + S +L AE + + + E ++G EG G +E + E + EE +E+
Sbjct: 619 RKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEE--REK 676
Query: 1335 GVQLEETKETEGEGQQEEE-AQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEG 1393
G + + E E G+ E+E A+ EE ++ GE +++ E ++G + E E G
Sbjct: 677 GEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK-----EREQGHQKERNQEMEEGG 731
Query: 1394 LKE--EGLPEEGSVHGQELSEA-SSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP 1450
+E EG EEG +E E +G+G + + ++EE R +G EE
Sbjct: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEG 791
Query: 1451 TEPPSHLSETDPSASERQSGSQLEPG-LEKPPGATMMGQEHTQAQPTQGAAE 1501
+ ET+ E++ G ++E G +E+ G +E + + +G E
Sbjct: 792 DQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843
Score = 43.1 bits (100), Expect = 0.003
Identities = 54/247 (21%), Positives = 92/247 (37%), Gaps = 47/247 (19%)
Query: 1281 EEQRASSNLEQLAENTVQEEV----QLEETKEGTEGEGLQEEAVQ----LEETKTEEGLQ 1332
++Q+ + +L ++T E + EE E EG+ ++ Q + T E
Sbjct: 521 QKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS 580
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGL--QGEAL 1390
+E V++ E KE E++ G G++E+ V+ E GG + E L
Sbjct: 581 DEEVEIPEEKEGA--------------EDSKGNGIEEQEVEANEENVKVHGGRKEKTEIL 626
Query: 1391 EEGLKEEGLPEEGSVHGQELSEASSPDGKG--------------SQEDDPVQEEEAGRAS 1436
+ L ++ EG +E P+G+G E+ E++ GR
Sbjct: 627 SDDLTDKAEVSEGKAKSVGEAE-DGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGE 685
Query: 1437 ASAEPCPAEGTEEPTEPPSHLSE--TDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQ 1494
P EG +E E + ER+ G Q E E G +EH + +
Sbjct: 686 MER---PGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGE---EEHGEGE 739
Query: 1495 PTQGAAE 1501
+G E
Sbjct: 740 EEEGDRE 746
Score = 38.5 bits (88), Expect = 0.080
Identities = 45/190 (23%), Positives = 59/190 (31%), Gaps = 12/190 (6%)
Query: 874 GSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGG 933
G + GG +EG + G +G G E K G
Sbjct: 805 GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE 864
Query: 934 PQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVD 993
+G+EE E E EE E E G G G E +
Sbjct: 865 GEGEEEGE--------EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEE 916
Query: 994 ---PGDDHSLEGLGE-PAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPE 1049
G++ EG GE + G+ E G+ E EG G + G GE +G E
Sbjct: 917 GEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEE 976
Query: 1050 GVSEAPAEAG 1059
G E E G
Sbjct: 977 GEGEGEEEEG 986
Score = 37.7 bits (86), Expect = 0.14
Identities = 49/197 (24%), Positives = 63/197 (31%), Gaps = 15/197 (7%)
Query: 871 GSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNS---GASRRSSASQGAGSRGLSEEKT 927
G G + G G +E G G G +G G E K
Sbjct: 862 GEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKG 921
Query: 928 LRSGGGPQGQ-EEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGG 986
G +G+ EE G E EW EE E E G G G
Sbjct: 922 EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE--EEEGEGEGEEEGEGEGEEGEG 979
Query: 987 LRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGA 1046
E G+ EG E + G+ EG+ + E EG + G + + GEG
Sbjct: 980 EGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEG--EVEGEEGEG----- 1032
Query: 1047 APEGVSEAPAEAGADRE 1063
EG E E G +RE
Sbjct: 1033 --EGEEEEGEEEGEERE 1047
Score = 35.0 bits (79), Expect = 0.89
Identities = 36/167 (21%), Positives = 50/167 (29%), Gaps = 8/167 (4%)
Query: 444 GRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDP 503
G E + G EG E E E+G G + G GE+
Sbjct: 858 GEEEGEEGEGEEEGEEGEGEGEEEEGE--GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEE 915
Query: 504 GLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAE- 562
+G G G E+G EEG E EW G + G+ E
Sbjct: 916 ----EGEGKG-EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970
Query: 563 TSQQEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTRE 609
+ E EG + + E +G+G E+ G E
Sbjct: 971 EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017
Score = 33.9 bits (76), Expect = 2.0
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 9/88 (10%)
Query: 984 GGGLRGPEVDPG----DDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSG 1039
GG + G EV+ G ++ EG GE + + EG+ G++ E EG + + G
Sbjct: 811 GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGE-GEEEEGEG----KGEEEGEEG 865
Query: 1040 EGVPQGAAPEGVSEAPAEAGADREAPAG 1067
EG +G EG E G E G
Sbjct: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEG 893
>gi|5454016 retinitis pigmentosa RP1 protein [Homo sapiens]
Length = 2156
Score = 172 bits (437), Expect = 3e-42
Identities = 107/328 (32%), Positives = 176/328 (53%), Gaps = 8/328 (2%)
Query: 26 SVTKVTPAKKITFLKRGDPRFAGVRLAVHQRAFKTFSALMDELSQRVPLSFGVRSVTTPR 85
S+T AK+I+F K GDP+F GVR+ V+ R+FK+F AL+D LS++VPL FGVR+++TPR
Sbjct: 28 SLTHPVVAKRISFYKSGDPQFGGVRVVVNPRSFKSFDALLDNLSRKVPLPFGVRNISTPR 87
Query: 86 GLHSLSALEQLEDGGCYLCSDKKPPKTPSGPGRPQERNPTAQQLRDVEGQREAPGTSSSR 145
G HS++ LE+LEDG YLCS + + + P P ++
Sbjct: 88 GRHSITRLEELEDGESYLCSHGRKVQPVDLDKARRRPRPWLSSRAISAHSPPHPVAVAAP 147
Query: 146 KSLKTPRRILLIKNMDPRLQQTVVLSHRNTRNLAAFLGKASDLLRFPVKQLYTTSGKKVD 205
+ PR +++ +N DP+ ++ V+LS R T++ AFL +++++ PV +LY T G++V
Sbjct: 148 GMPRPPRSLVVFRNGDPKTRRAVLLSRRVTQSFEAFLQHLTEVMQRPVVKLYATDGRRVP 207
Query: 206 SLQALLHSPSVLVCAGHEAFRTPAMKNARRSEAETLSGLTSR--NKNGSWGPKTKPSVIH 263
SLQA++ S +V AG E F+ + L G++ R K + K S
Sbjct: 208 SLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPARLPGISQRVYPKGNAKSESRKISTHM 267
Query: 264 SRSPPGSTPRLPERPGPSNP-----PVGPAPGRHPQDTPAQSGPLV-AGDDMKKKVRMNE 317
S S + +N P + +Q+ P+ + DD++K + N+
Sbjct: 268 SSSSRSQIYSVSSEKTHNNDCYLDYSFVPEKYLALEKNDSQNLPIYPSEDDIEKSIIFNQ 327
Query: 318 DGSLSVEMKVRFHLVGEDTLLWSRRMGR 345
DG+++VEMKVRF + E+T+ W+ + +
Sbjct: 328 DGTMTVEMKVRFRIKEEETIKWTTTVSK 355
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 130 bits (327), Expect = 2e-29
Identities = 141/560 (25%), Positives = 248/560 (44%), Gaps = 45/560 (8%)
Query: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQE-----AEGEAQPESEDVEAPEAEGEAQPESEDV 1890
E EA+ E E EG E EAEG +E AE A PE E + E ++ E++
Sbjct: 474 EEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSP 533
Query: 1891 ETPEAEWEVQPES-EGAEAP-EAEKEAQPETESVEALETEGEDEPES-EGAEAQEAEEAA 1947
E EA+ + +S E A++P + E ++ PE +S E E + E +S E A++ EEA
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593
Query: 1948 QEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG 2007
AE ++ +++ +EA+ A+ +S E + E + E P E+ ++PE +
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE-KA 652
Query: 2008 EMQEAEEEAQPE--SDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQ 2065
+ E EE PE V+A+ KS + V+ E + E P + EA E+
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE--EAKSPEKAKS 710
Query: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE--GIEAPETEG 2123
+ E + E P E +A+ E P E ++PE +KA+ +++PE +
Sbjct: 711 PVKEEAKSPEKAKSPVKE--EAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKT 768
Query: 2124 EAQPES--------EGIEAPEAEGEAQPE-SEGVEAQDAEGEAQ--PESEGIEAQEAEEE 2172
A+ E+ E ++P E PE ++ +DA+ + P+ E +++ EEE
Sbjct: 769 PAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE 828
Query: 2173 AQPELEGVEAP-EAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP 2231
E++ E P +AE E P + E E + + E EAP+ + E + EP +
Sbjct: 829 KPQEVKVKEPPKKAEEEKAPATPKTE--EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPK 886
Query: 2232 EAEGEAQPESEGETQ----GEKKGSPQVSL-GDGQSEEASESSSPVPEDRPTPPPSPGGD 2286
E++ EA+ E + + EK+ +V + D + +E +E + P+D PS
Sbjct: 887 ESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPS---- 942
Query: 2287 TPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPE 2346
+P + + + + +K E + D K+ ++ KA +
Sbjct: 943 ----KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD-KTLSKEPSKPKAEKAEKS 997
Query: 2347 SSTSEQEEAPLGSRTPEQGA 2366
SST +++ P T ++ A
Sbjct: 998 SSTDQKDSKPPEKATEDKAA 1017
Score = 128 bits (321), Expect = 8e-29
Identities = 133/574 (23%), Positives = 254/574 (44%), Gaps = 49/574 (8%)
Query: 1768 MAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQG---EAAAGGDQ 1824
+ +E+ +T +E E EA++E EG E G + G E+ + E AA ++
Sbjct: 456 IVEEQTEETQVTEEVTEEEEKEAKEE-EGKEEEGGEEEEAEGGEEETKSPPAEEAASPEK 514
Query: 1825 D---PGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEG 1881
+ P + + EA E E V++PE + E ++ PE++ E EA+
Sbjct: 515 EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKS 574
Query: 1882 EAQPES-EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEA 1940
A+ +S E ++P E P AEA EK P E EA P E A++
Sbjct: 575 PAEVKSPEKAKSPAKEEAKSP----AEAKSPEKAKSPVKE--EAKSPAEAKSPVKEEAKS 628
Query: 1941 QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDV 2000
++ ++A+ T+ E++ E ++ E+ + +S + V+ E + E P +
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA 688
Query: 2001 EAPE-AEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059
++PE A+ ++E + + V+ + KS + V+ E + E P + ++PE
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE 748
Query: 2060 ---AEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116
+ E+A+ + + EA+ A E+ + E P E V++PE + ++ E
Sbjct: 749 KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE-KAKSPLKEDA 807
Query: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVE----AQDAEGEAQPESEGIEAQEAEEE 2172
+APE E P+ E +++P E E E + E A++ + A P++E E +++++E
Sbjct: 808 KAPEKE---IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTE--EKKDSKKE 862
Query: 2173 AQPELEG----VEAPEAEGEAQPESEGIEAPEAEGEAQ-----PELEGVEAPEAEEEAQP 2223
P+ E VE + +P+ +EA + E E + PE E E +E+A+P
Sbjct: 863 EAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKP 922
Query: 2224 EPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSP 2283
+ + + +A+ + + +K+ +P + ++ E + PE++P
Sbjct: 923 KEKTEVAKKEPDDAKAKEPSKPAEKKEAAP-------EKKDTKEEKAKKPEEKPKTEAKA 975
Query: 2284 GGD--TPHQRPGSQTGPSSSRASSWGNCWQKDSE 2315
D T + P P + +A + QKDS+
Sbjct: 976 KEDDKTLSKEPSK---PKAEKAEKSSSTDQKDSK 1006
Score = 116 bits (290), Expect = 3e-25
Identities = 139/575 (24%), Positives = 237/575 (41%), Gaps = 56/575 (9%)
Query: 1843 EAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE 1902
E Q E V E + +EA+ E E E E EAEG E+ ++P AE PE
Sbjct: 458 EEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGG----EEETKSPPAEEAASPE 513
Query: 1903 SEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962
E + E ++ E +S E E + E +S ++A+ A+E E ++ PE++ E
Sbjct: 514 KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP----EKAKSPAKE-EAKSPPEAKSPE 568
Query: 1963 SQEAEEEAQPESED------VEALEVEVETQEAEGEAQPESEDVEAP-EAEGEM-QEAEE 2014
+EA+ A+ +S + E + E + E P E+ ++P EA+ + +EA+
Sbjct: 569 KEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKS 628
Query: 2015 EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG---VEAPEAEEEAQEAEGEV 2071
A+ +S P E ++ E +K E + ++ EA E+ + E
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA 688
Query: 2072 QEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE-----AEGEAQKAEGIEAPETEGEAQ 2126
+ E P E +A+ E P E ++PE + EA+ E ++P E
Sbjct: 689 KSPEKAKSPVKE--EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKS 746
Query: 2127 PESE---------GIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPEL 2177
PE +++PEA+ A+ E+ + E P E E + E+ P
Sbjct: 747 PEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE--EVKSPEKAKSPLK 804
Query: 2178 EGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAP-EAEEEAQP-EPEGVETPEAEG 2235
E +APE E P+ E +++P E E E++ E P +AEEE P P+ E +++
Sbjct: 805 EDAKAPEKE---IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861
Query: 2236 EAQPESEG-ETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTP---PPSPGGDTPHQR 2291
E P+ E + + E+K P V EA + + + PTP P+ +
Sbjct: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921
Query: 2292 PGSQT-----GPSSSRASSWGNCWQK----DSENDHVLGDTRSPDAKSTGTPHAERKATR 2342
P +T P ++A +K + D + P+ K A+
Sbjct: 922 PKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKT 981
Query: 2343 MYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQA 2377
+ E S + E+A S T ++ + ED+A
Sbjct: 982 LSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKA 1016
Score = 104 bits (259), Expect = 1e-21
Identities = 136/561 (24%), Positives = 227/561 (40%), Gaps = 62/561 (11%)
Query: 1866 EAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEAL 1925
+++ E+ VE E + E + E EA+ E E EG E EAE + ET+S A
Sbjct: 449 KSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG-GEEETKSPPAE 507
Query: 1926 ETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIES---------------QEAEEEA 1970
E PE E A++ EEA AE ++ PE E +S +EA+
Sbjct: 508 EAAS---PEKE-AKSPVKEEAKSPAEAKS-PEKEEAKSPAEVKSPEKAKSPAKEEAKSPP 562
Query: 1971 QPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSE 2030
+ +S + E + E + E P E+ ++P AE + E + E A+ KS
Sbjct: 563 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP-AEAKSPEKAKSPVKEEAKSPAEAKSP 621
Query: 2031 GEEAQEVEGETQKTEGDAQPESDGVEAPE-----AEEEAQEAEGEVQEAEGEA-HPESE- 2083
+E + E + E P + ++PE +EEA+ E + EA PE
Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 2084 ---DVDAQEAEGEAQPESEGVEAPE-----AEGEAQKAEGIEAPETEGEAQPE------S 2129
+A+ E P E ++PE + EA+ E ++P E PE
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVK 741
Query: 2130 EGIEAPE-AEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGE 2188
E ++PE A+ + ++ V++ +A+ A+ E+ + E+ P E V++PE
Sbjct: 742 EEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK--A 799
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETP----EAEGEAQPESEGE 2244
P E +APE E P+ E V++P EEE E + E P E + A P++E +
Sbjct: 800 KSPLKEDAKAPEKE---IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEK 856
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304
+K+ +P+ + EE E + P++ + + P T + A
Sbjct: 857 KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP---TPEKEAPAK 913
Query: 2305 SWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
K E V + PD P + PE +++E+A + PE+
Sbjct: 914 VEVKEDAKPKEKTEVA--KKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKA----KKPEE 967
Query: 2365 GASEGYDLQEDQALGSLAPTE 2385
+ED S P++
Sbjct: 968 KPKTEAKAKEDDKTLSKEPSK 988
Score = 102 bits (255), Expect = 3e-21
Identities = 117/502 (23%), Positives = 212/502 (42%), Gaps = 58/502 (11%)
Query: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVI 1961
E E E++ + + E E E ++ E EG E + EE +EAEG E
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEE--EEAEG----GEEET 501
Query: 1962 ESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESD 2021
+S AEE A PE E ++ +EA+ A+ +S + E ++ E++ E+ P +
Sbjct: 502 KSPPAEEAASPEKEAKSPVK-----EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKE 556
Query: 2022 GVEAQPKSEGEEAQEVE--GETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAH 2079
++ P+++ E +E + E + E P + ++P + ++A+ V+E E ++
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKE-EAKSP 615
Query: 2080 PESEDVDAQEAEGEAQPES-EGVEAPEAEGEAQKAEGIEAPETEGEAQPE--SEGIEAPE 2136
E++ +EA+ A+ +S E ++P E EA+ E ++PE E PE ++A
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKE-EAKSPEKAKSPEKEEAKSPEKAKSPVKAEA 674
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPE------------ 2184
E EA+ E P E EA+ E+ P E ++PE
Sbjct: 675 KSPEKAKSPVKAEAKSPEKAKSPVKE--EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 2185 AEGEAQPESEGIEAPE-AEGEAQPELEGVEAPEAEEEAQPE--------PEGVETPEAEG 2235
E P E ++PE A+ + + V++PEA+ A+ E PE ++P E
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 2236 EAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295
PE E +P+ + + E SPV E+ P P ++ +
Sbjct: 793 VKSPEKAKSPLKEDAKAPEKEI-----PKKEEVKSPVKEEE--KPQEVKVKEPPKKAEEE 845
Query: 2296 TGPSSSRASSWGNCWQKDSENDHV-LGDTRSPDAKSTGTPHAER-KATRMYPESSTSEQE 2353
P++ + +KDS+ + + P + P E+ K +++ + E+
Sbjct: 846 KAPATPKTEE-----KKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV---EAKKEEA 897
Query: 2354 EAPLGSRTPEQGASEGYDLQED 2375
E TPE+ A +++ED
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKED 919
Score = 85.9 bits (211), Expect = 4e-16
Identities = 165/714 (23%), Positives = 284/714 (39%), Gaps = 98/714 (13%)
Query: 1676 MGATRGPIKEAF-----DLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGL 1730
+GA RG ++ D+ + QR E E AE A R Q AE
Sbjct: 160 LGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARAL------ARFAQEAEAAR 213
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQ-EREGKTHNS----ETSAGS 1785
+ + E E G + + LG+ +G AQ + + +T ++ TSA
Sbjct: 214 VDLQKKAQALQE-ECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALR 272
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
E+ A+ EG + ++ D L A D + E E + Q
Sbjct: 273 EI-RAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQE-----EITEYRRQLQ 326
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDV-EAPEAEGEAQPESEDVETPEAEWEVQPE-S 1903
+ +EA ++ D+ E + + E ED +A A + + D E +WE+ +
Sbjct: 327 ARTTELEALKSTKDSLERQ---RSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLR 383
Query: 1904 EGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIES 1963
E + + E + L EGE+ G E + S I+
Sbjct: 384 EYQDLLNVKMALDIEIAAYRKL-LEGEECRIGFGPIPFSLPEGLPKIPSV----STHIKV 438
Query: 1964 QEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGV 2023
+ E+ E + E + VE +T+E + V E E +EA+EE E +G
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQ---------VTEEVTEEEEKEAKEEEGKEEEGG 489
Query: 2024 EAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEG---EVQEAEGEAHP 2080
E + GEE E ++ E A PE + ++P EE AE E +EA+ A
Sbjct: 490 EEEEAEGGEE----ETKSPPAEEAASPEKE-AKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 2081 ESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
+S + A+ EA+ E ++PE E EA+ +++PE P E ++P AE +
Sbjct: 545 KSPEKAKSPAKEEAKSPPE-AKSPEKE-EAKSPAEVKSPEK--AKSPAKEEAKSP-AEAK 599
Query: 2141 AQPESEGVEAQDAEGEAQPES-------EGIEAQEAEEEAQPELEGVEAPEAEGEAQPES 2193
+ +++ ++A+ A+ +S E + E+ P E ++PE PE
Sbjct: 600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEK--AKSPEK 657
Query: 2194 EGIEAPE-AEGEAQPELEGVEAPEAEEEAQPE-PEGVETPEAEGEAQPESEGETQGEKKG 2251
E ++PE A+ + E + E ++ +A+ + PE ++P E PE E+
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 2252 SPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQ 2311
SP+ ++ SPV E+ TP + + P + S +A
Sbjct: 718 SPE------------KAKSPVKEEAKTPEKA-------KSPVKEEAKSPEKA-------- 750
Query: 2312 KDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS---EQEEAPLGSRTP 2362
K E L D +SP+AK+ A A + +PE + S E+ ++P +++P
Sbjct: 751 KSPEKAKTL-DVKSPEAKTPAKEEARSPADK-FPEKAKSPVKEEVKSPEKAKSP 802
Score = 80.9 bits (198), Expect = 1e-14
Identities = 107/513 (20%), Positives = 198/513 (38%), Gaps = 53/513 (10%)
Query: 1645 SQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGA--TRGPIKEAFDLQQILQRKRGEHTD 1702
S + EEA+ P EA +K SP + P KE + E
Sbjct: 518 SPVKEEAKS----PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAK 573
Query: 1703 GEAAEVAPGKTHT-------DPTSTRTVQGA-----EGGLGPGLSQGPGVDEGEDGEGSQ 1750
A +P K + P ++ + A E P ++ P +E + +
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVK 633
Query: 1751 RLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH 1810
+ K P EA+ A+ E + S A S + + E + +
Sbjct: 634 SPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK 693
Query: 1811 EDNLQGEAAAGGDQDPG----QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGE 1866
+ E A ++ ++ E ++P E PE E ++A+
Sbjct: 694 AKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP 753
Query: 1867 AQPESEDVEAPEAEGEAQ----------------PESEDVETPEAEWEVQPESEGAEAPE 1910
+ ++ DV++PEA+ A+ P E+V++PE P E A+APE
Sbjct: 754 EKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK--AKSPLKEDAKAPE 811
Query: 1911 AEKEAQPETESVEALETEGED----EP----ESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962
E + E +S E + ++ EP E E A A E ++++ + P+ E
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEA-P 870
Query: 1963 SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ EE+ +P E + +VE + +EAE + + + + EAP E +E+A+P+
Sbjct: 871 KPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAP----AKVEVKEDAKPKEKT 926
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
A+ + + +A+E +K E + + E + EE + E + +E + E
Sbjct: 927 EVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986
Query: 2083 EDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG 2115
A++AE + + + + PE E + A+G
Sbjct: 987 SKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKG 1019
Score = 79.3 bits (194), Expect = 4e-14
Identities = 161/714 (22%), Positives = 265/714 (37%), Gaps = 88/714 (12%)
Query: 1674 ATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPG 1733
A +GA P+ L L RK G AA + G TS +V + P
Sbjct: 9 ALLGAPFAPLHGGGSLHYALARKGGAGGTRSAAGSSSGFHSWTRTSVSSVSAS-----PS 63
Query: 1734 LSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQE 1793
+G G D D ++ EG TS SE + +
Sbjct: 64 RFRGAGAASSTDSL------------------DTLSNGPEGCMVAVATSR-SEKEQLQAL 104
Query: 1794 GEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEA 1853
+ + + Q H +L+GEAAA Q G+S A GE E E E
Sbjct: 105 NDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRS----------AMGELY-EREVREM 153
Query: 1854 PEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEK 1913
A A G+ + E E + A + + E + EAE + + A+ EA +
Sbjct: 154 RGAVLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAAR 213
Query: 1914 -EAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQP 1972
+ Q + ++++ E G + +E E GQ Q +AQ
Sbjct: 214 VDLQKKAQALQ----------EECGYLRRHHQEEVGELLGQIQGSGAA--------QAQM 255
Query: 1973 ESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGE-----MQEAEEEAQPESDGVEAQP 2027
++E +AL+ +V + E AQ E V++ E + E A+ +D + +
Sbjct: 256 QAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQ 315
Query: 2028 KSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE-EEAQEAE-----GEVQEAEGEAHPE 2081
+ E ++++ T + E + D +E +E E+ +A+ +Q+ + E
Sbjct: 316 EEITEYRRQLQARTTELEA-LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNT 374
Query: 2082 SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPES--EGI-EAPEAE 2138
++ AQ E + + E + EG E G P S EG+ + P
Sbjct: 375 KWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPI-PFSLPEGLPKIPSVS 433
Query: 2139 GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEA 2198
+ +SE + + + E E + +E EE Q E E E E + E EG E
Sbjct: 434 THIKVKSE----EKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAK---EEEGKE- 485
Query: 2199 PEAEGEAQPELEGVE----APEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
EG + E EG E +P AEE A PE E + E ++ E++ + E K +
Sbjct: 486 --EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAE 543
Query: 2255 VSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDS 2314
V + A E + PE + + P P+ A S +
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEK 603
Query: 2315 ENDHVLGDTRSP-DAKSTGTPHAERKATRMYPE---SSTSEQEEAPLGSRTPEQ 2364
V + +SP +AKS A+ A PE S T E+ ++P +++PE+
Sbjct: 604 AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
Score = 79.0 bits (193), Expect = 5e-14
Identities = 112/542 (20%), Positives = 219/542 (40%), Gaps = 63/542 (11%)
Query: 1649 EEAEGEE----FCPCEACV---RKKVSPMSPKATMGA-TRGPIKEAFDLQQILQRKRGEH 1700
EEAEG E P E ++ SP+ +A A + P KE + + + K E
Sbjct: 492 EEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKE--EAKSPAEVKSPEK 549
Query: 1701 TDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKL 1760
A E A + P ++ P +E + ++ + K P
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 1761 GEAEGDAMAQE---------------REGKTHNSETSAGSELGEAEQEGEGIS-ERGETG 1804
EA+ A A+ + K+ E + E ++ ++ E S E+ ++
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP 669
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPE-----AEGD 1859
+ + P ++ EA E P E ++PE + +
Sbjct: 670 VKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729
Query: 1860 AQEAEGEAQPESEDVEAPE-AEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPE 1918
A+ E P E+ ++PE A+ + ++ DV++PEA+ + E+ EK P
Sbjct: 730 AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPV 789
Query: 1919 TESVEALET------EGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEA 1970
E V++ E E PE E + +E + +E E +P+ ++ ++AEEE
Sbjct: 790 KEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEE---KPQEVKVKEPPKKAEEEK 846
Query: 1971 QP---------ESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESD 2021
P +S+ EA + E + E + +P E + + E + +EAE++ + +
Sbjct: 847 APATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTP 906
Query: 2022 GVEAQPKSEGEEAQEVEGETQ---KTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEA 2078
EA K E +E + + +T+ K DA+ + P E +EA E ++ + E
Sbjct: 907 EKEAPAKVEVKEDAKPKEKTEVAKKEPDDAK-----AKEPSKPAEKKEAAPEKKDTKEEK 961
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAE 2138
+ E + + E +A+ + + + ++ +A+KAE + + + +++P + E A+
Sbjct: 962 AKKPE--EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD-QKDSKPPEKATEDKAAK 1018
Query: 2139 GE 2140
G+
Sbjct: 1019 GK 1020
Score = 66.2 bits (160), Expect = 4e-10
Identities = 142/672 (21%), Positives = 254/672 (37%), Gaps = 104/672 (15%)
Query: 1333 EEGVQLEETKETEG---EGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEA 1389
EE +++ E E E E Q EE EE+ E EE KE E
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTE-------------EEEKEAKE------- 480
Query: 1390 LEEGLKEEGLPEEGSVHGQE------LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCP 1443
EEG +EEG EE + G+E EA+SP+ + PV+EE ++ A A+
Sbjct: 481 -EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPE---KEAKSPVKEE--AKSPAEAKSPE 534
Query: 1444 AEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERS 1503
E + P E S P+ E +S PP A +E ++ + E++
Sbjct: 535 KEEAKSPAEVKSPEKAKSPAKEEAKS----------PPEAKSPEKEEAKSPAEVKSPEKA 584
Query: 1504 SSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQD 1563
S A A K EKA S V E + + ++ + +
Sbjct: 585 KSPAKEEAKS------PAEAKSPEKA-----KSPVKEEAKSPAEAKSPVKEEAKSPAEVK 633
Query: 1564 VAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERT 1623
++ + TK E ++ P +E ++ + + S
Sbjct: 634 SPEKAKSPTKEE-----AKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA 688
Query: 1624 LGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKA-TMGATRGP 1682
+++E S + EEA+ E K SP+ +A T + P
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE---------KAKSPVKEEAKTPEKAKSP 739
Query: 1683 IKEAFDLQQILQRKRGEHTDG-EAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVD 1741
+KE + K E E A+ K+ T + + P ++ P +
Sbjct: 740 VKE--------EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE 791
Query: 1742 EGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERG 1801
E + E ++ ++ D K E E + ++ E K+ E E+ E + E+
Sbjct: 792 EVKSPEKAKSPLKE-DAKAPEKE---IPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA 847
Query: 1802 ETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQ 1861
+ +D+ + EA EAP+ + E + E + E++ +A+
Sbjct: 848 PATPKTEEKKDSKKEEAPKK--------------EAPKPKVEEKKEPAVEKPKESKVEAK 893
Query: 1862 EAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEV-QPESEGAEAPEAEKEAQPETE 1920
+ E E + + V PE E A+ E ++ P+ + EV + E + A+A E K A+ +
Sbjct: 894 KEEAE---DKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 1921 SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL 1980
+ E +T+ E + E E + E A+E + E ++++AE+ + + +D +
Sbjct: 951 APEKKDTKEEKAKKPE--EKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008
Query: 1981 EVEVETQEAEGE 1992
E E + A+G+
Sbjct: 1009 EKATEDKAAKGK 1020
Score = 54.3 bits (129), Expect = 1e-06
Identities = 138/632 (21%), Positives = 226/632 (35%), Gaps = 100/632 (15%)
Query: 1290 EQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGE-- 1347
EQ E V EEV EE KE E EG +EE + EE + E EETK E
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE---------EETKSPPAEEA 509
Query: 1348 GQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHG 1407
E+EA+ ++E + + + EE K E +A +E P E
Sbjct: 510 ASPEKEAK-SPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK--S 566
Query: 1408 QELSEASSPDGKGSQE--DDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSAS 1465
E EA SP S E P +EE A A + +E + P+ P
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK--SPVKE 624
Query: 1466 ERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKK 1525
E +S ++ ++ P A +E ++ + E+ + + A V K
Sbjct: 625 EAKSPAE----VKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSP----VKAEAKS 676
Query: 1526 TEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQ--DSTKRELQKLQGRA 1583
EKA A A + +A+ +++ + A ++ A+ + S +E K +A
Sbjct: 677 PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKA 736
Query: 1584 GRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGL-GPLSFTLEDEPALSTA 1642
V E EA + E + S +TL + P + T E A S A
Sbjct: 737 KSPVKE---EAKSPE---------------KAKSPEKAKTLDVKSPEAKTPAKEEARSPA 778
Query: 1643 ------LGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRK 1696
S + EE + E K SP+ A + P KE +++
Sbjct: 779 DKFPEKAKSPVKEEVKSPE---------KAKSPLKEDA-----KAPEKEIPKKEEVKSPV 824
Query: 1697 RGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRD- 1755
+ E E P K + + T P +E +D + + ++
Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPAT---------------PKTEEKKDSKKEEAPKKEA 869
Query: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQ 1815
PK+ E + A+ + +E K ++ EAE + + + E + ED
Sbjct: 870 PKPKVEEKKEPAVEKPKESKVE-------AKKEEAEDKKKVPTPEKEAPAKVEVKEDAKP 922
Query: 1816 GEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGV---------EAPEAEGDAQEAEGE 1866
E ++P + E P + EA PE + E P+ E A+E +
Sbjct: 923 KEKTEVAKKEPDDAKAKEP-SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKT 981
Query: 1867 AQPESEDVEAPEAEGEAQPESEDVETPEAEWE 1898
E +A +AE + + +D + PE E
Sbjct: 982 LSKEPSKPKAEKAEKSSSTDQKDSKPPEKATE 1013
Score = 47.0 bits (110), Expect = 2e-04
Identities = 49/189 (25%), Positives = 78/189 (41%), Gaps = 15/189 (7%)
Query: 1296 TVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQ 1355
+V ++++ ++ E ++E V +EE E + EE + EE + E EG++EE +
Sbjct: 431 SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE 490
Query: 1356 LEEIEETGGEGLQEEGVQLEEVKEGP--EGGLQGEALEEGLKEEGLPEEGSVHGQELSEA 1413
EE E GGE EE K P E + + +KEE E EA
Sbjct: 491 EEEAE--GGE---------EETKSPPAEEAASPEKEAKSPVKEEA-KSPAEAKSPEKEEA 538
Query: 1414 SSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQL 1473
SP S E +E ++ A+ E + P E S P+ E +S ++
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 1474 E-PGLEKPP 1481
+ P K P
Sbjct: 599 KSPEKAKSP 607
Score = 45.8 bits (107), Expect = 5e-04
Identities = 121/612 (19%), Positives = 227/612 (37%), Gaps = 63/612 (10%)
Query: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEE--AVQLEETKTEEGLQEE 1334
E+ E Q E+ + +EE + EE E E EG +EE + EE + E +
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS 518
Query: 1335 GVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGL 1394
V+ E E + ++EEA+ E E + + EE K PE + +
Sbjct: 519 PVKEEAKSPAEAKSPEKEEAK-SPAEVKSPE--KAKSPAKEEAKSPPEAKSPEKEEAKSP 575
Query: 1395 KEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPP 1454
E PE+ +E EA SP S E +E ++ A A+ E + P E
Sbjct: 576 AEVKSPEKAKSPAKE--EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVK 633
Query: 1455 SHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDC 1514
S P+ E +S P K P E +A+ + A + A S
Sbjct: 634 SPEKAKSPTKEEAKS-----PEKAKSP-------EKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 1515 DPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQ--DST 1572
P V K EKA A + +A+ +++ + A ++ A+ + S
Sbjct: 682 SP--VKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 1573 KRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFT 1632
+E K +A + P +A T ++ + + F E+
Sbjct: 740 VKEEAKSPEKA-----KSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA------KSP 788
Query: 1633 LEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQI 1692
+++E S L E+A+ E K++ PK + P+KE Q++
Sbjct: 789 VKEEVKSPEKAKSPLKEDAKAPE---------KEI----PKKE--EVKSPVKEEEKPQEV 833
Query: 1693 LQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRL 1752
++ + + E A P + E + P V+E ++ +
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE-------APKPKVEEKKE----PAV 882
Query: 1753 NRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGE--AEQEGEGISERGETGGQGSGH 1810
+ K+ K+ EA+ + +++ T E A E+ E +E ++++ +
Sbjct: 883 EKPKESKV-EAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP 941
Query: 1811 EDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPE 1870
+ + AA +D + + E P+ E +A+ + + + ++ A++AE + +
Sbjct: 942 SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTD 1001
Query: 1871 SEDVEAPEAEGE 1882
+D + PE E
Sbjct: 1002 QKDSKPPEKATE 1013
Score = 38.9 bits (89), Expect = 0.061
Identities = 59/291 (20%), Positives = 118/291 (40%), Gaps = 24/291 (8%)
Query: 1231 PLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLE 1290
P K + P+ + ++ ++ P A++ A + +AE S E+ S E
Sbjct: 641 PTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE 700
Query: 1291 QL-----AENTVQEEVQLEE-----TKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEE 1340
+ A++ V+EE + E KE + + V+ E E+ E + +
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
Query: 1341 TKETEGEGQQEEEAQ--LEEIEETGGEGLQEEGVQLEEVK-------EGPEGGL-QGEAL 1390
K E + +EEA+ ++ E ++EE E+ K + PE + + E +
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820
Query: 1391 EEGLKEEGLPEEGSVH--GQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTE 1448
+ +KEE P+E V ++ E +P ++E ++EEA + A +P E E
Sbjct: 821 KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEA-PKPKVEEKKE 879
Query: 1449 EPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGA 1499
E P S+ + E + ++ ++ P + ++ + T+ A
Sbjct: 880 PAVEKPKE-SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVA 929
Score = 38.1 bits (87), Expect = 0.10
Identities = 59/268 (22%), Positives = 107/268 (39%), Gaps = 29/268 (10%)
Query: 1239 PDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQ-----RASSNLEQLA 1293
P +SP ++++ ++ PT A++ A + ++ E S E+ +A + + A
Sbjct: 621 PVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA 680
Query: 1294 ENTVQEEVQL---------EETKEGTEGEG-LQEEAVQLEETKTEEGLQEEGVQLEETKE 1343
++ V+ E + EE K + + ++EEA E+ K+ ++EE E+ K
Sbjct: 681 KSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP--VKEEAKTPEKAKS 738
Query: 1344 -TEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEE 1402
+ E + E+A+ E +T E +E P +A +E PE+
Sbjct: 739 PVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK 798
Query: 1403 GSVHGQELSEASSPD-GKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD 1461
+E ++A + K + PV+EEE + EP P + EE E
Sbjct: 799 AKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEP-PKKAEEEKAPATPKTEEKK 857
Query: 1462 PSASERQSGSQL---------EPGLEKP 1480
S E + EP +EKP
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 128 bits (322), Expect = 6e-29
Identities = 171/578 (29%), Positives = 241/578 (41%), Gaps = 86/578 (14%)
Query: 1757 DPKLGEAEGDAMAQEREGKTHNSE-------TSAGSELGEAEQEGEGISERGETGGQGSG 1809
D +++ DA+ + GK SE T++ E+G+ ++ + G
Sbjct: 171 DSSSTKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVL- 229
Query: 1810 HEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQP 1869
ED L+ E P +G+ + AE E P +E A +EA +A+P
Sbjct: 230 LEDELREEVTV-----PVVQEGSAVKKVASAEIEP-PSTEKFPAKIQPPLVEEATAKAEP 283
Query: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEG 1929
A E + QP +E ETP+AE + A A + K P E +E
Sbjct: 284 RP----AEETHVQVQPSTE--ETPDAE------AATAVAENSVKVQPPPAEEAPLVEFPA 331
Query: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEA 1989
E +P S AE + E E P +E S+E E P + ++ VE+ +
Sbjct: 332 EIQPPS--AEESPSVELLAEI---LPPSAEESPSEEPPAEILPPPAE-KSPSVELLGEIR 385
Query: 1990 EGEAQPESEDVEAPEAEGEMQEAEEEAQP---ESDGVEAQP----KSEGEEAQEVEGET- 2041
AQ +V+ AEG ++EA + +P E + QP ++ EEA+E++ T
Sbjct: 386 SPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTA 445
Query: 2042 QKTEGDAQPESDGVEAPEAEEEAQEAEGEVQ----------EAEGEAH-PESEDVDAQEA 2090
+T + P P+ E A+EA E+Q E EA P SE+ A+EA
Sbjct: 446 METPAEEAPTEFQSPLPK-ETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEA 504
Query: 2091 EGEAQ-PESEGVEAPEAEGEAQKAEGIEAP--ETEGEAQ-PESEGIEAPEAEGEAQ-PES 2145
E Q P +E A EA E Q IEAP ET EAQ P SE A EA E Q P +
Sbjct: 505 HAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSA 564
Query: 2146 EGVEAQDAEGEAQPES-EGIEAQEAE-------------EEAQPELEGVEAPEAEGEAQP 2191
+GV ++A E QP S E A+EA EEA E++ A EA E QP
Sbjct: 565 KGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQP 624
Query: 2192 ESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKG 2251
P AE EA E++ A EA E QP P EA E QP E E +
Sbjct: 625 -------PPAE-EAPAEVQPPPAEEAPAEVQPPP----AEEAPAEVQPPPAEEAPAEVQP 672
Query: 2252 SP-QVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTP 2288
P + + + QS A E +P+ E P D P
Sbjct: 673 PPAEEAPAEVQSLPAEE--TPIEETLAAVHSPPADDVP 708
Score = 93.2 bits (230), Expect = 3e-18
Identities = 169/689 (24%), Positives = 234/689 (33%), Gaps = 151/689 (21%)
Query: 1839 EAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAP--------------------- 1877
E + E + E V E D +EA E +DVE P
Sbjct: 80 EEKKEVKLVEETVVPEEKSADVREAAIELPESVQDVEIPPNIPSVQLKMDRSQQTSRTGY 139
Query: 1878 ----------EAEGEAQ---PESEDV--------ETPEAEWEVQPESEGAEAPEAEKEAQ 1916
+ + E Q ESE V T E ++ +S G E Q
Sbjct: 140 WTMMNIPPVEKVDKEQQTYFSESEIVVISRPDSSSTKSKEDALKHKSSGKIFASEHPEFQ 199
Query: 1917 PETESVEALETEG------------------EDEPESEGA--EAQEAEEAAQEAEGQTQP 1956
P T S E + + EDE E QE + A + +P
Sbjct: 200 PATNSNEEIGQKNISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEP 259
Query: 1957 ES----------EVIESQEAEEEAQP-ESEDVEALEVEVETQEAEGEAQPESEDVEA--- 2002
S ++E A+ E +P E V+ ET +AE V+
Sbjct: 260 PSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPP 319
Query: 2003 PEAEGEMQEAEEEAQP----ESDGVE-----AQPKSEGEEAQEVEGETQKTEGDAQPESD 2053
P E + E E QP ES VE P +E ++E E + P +
Sbjct: 320 PAEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVE 379
Query: 2054 ---GVEAPEAEEEAQE-----AEGEVQEAEGEAHP---ESEDVDAQEAEGEAQPESE--- 2099
+ +P A++ E AEG ++EA + P E D Q E P E
Sbjct: 380 LLGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARE 439
Query: 2100 -----GVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPE------SEGV 2148
+E P E + + T EA E + + A E + P SE
Sbjct: 440 LQLSTAMETPAEEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEET 499
Query: 2149 EAQDAEGEAQ-PESEGIEAQEAEEEAQPELEGVEAP--EAEGEAQ-PESEGIEAPEAEGE 2204
A++A E Q P +E A+EA E Q L +EAP E EAQ P SE A EA E
Sbjct: 500 SAEEAHAEVQSPLAEETTAEEASAEIQ-LLAAIEAPADETPAEAQSPLSEETSAEEAPAE 558
Query: 2205 AQ-PELEGVEAPEAEEEAQPEPEGVET-------------------PEAEGEAQP----E 2240
Q P +GV EA E QP P G ET EA E QP E
Sbjct: 559 VQSPSAKGVSIEEAPLELQP-PSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEE 617
Query: 2241 SEGETQGEKKGSPQVSLGDGQSEEASESSSPVP-EDRPT---PPPSPGGDTPHQRPGSQT 2296
+ E Q + +EEA P P E+ P PPP+ Q P ++
Sbjct: 618 APAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEE 677
Query: 2297 GPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAP 2356
P+ ++ +++ + L SP A P E + P + EE P
Sbjct: 678 APAEVQSLP-----AEETPIEETLAAVHSPPADD--VPAEEASVDKHSPPADLLLTEEFP 730
Query: 2357 LGSRTPEQGASEGYDLQEDQALGSLAPTE 2385
+G + E ED+AL TE
Sbjct: 731 IGEASAEVSPPPSEQTPEDEALVENVSTE 759
Score = 76.6 bits (187), Expect = 3e-13
Identities = 103/366 (28%), Positives = 144/366 (39%), Gaps = 43/366 (11%)
Query: 1802 ETGGQGSGHEDNLQGEAAAGGDQDPGQSDG--AEGIEAPEAEGEAQ-PESEGVEAPEA-- 1856
ET + + E L D+ P ++ +E A EA E Q P +E A EA
Sbjct: 464 ETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASA 523
Query: 1857 --------EGDAQEAEGEAQ-PESEDVEAPEAEGEAQ-PESEDVETPEAEWEVQPESEGA 1906
E A E EAQ P SE+ A EA E Q P ++ V EA E+QP S
Sbjct: 524 EIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPS--G 581
Query: 1907 EAPEAEKEAQPETESVEALETEGED------EPESEGAEAQEAEEAAQEAEGQTQPESEV 1960
E AE EA + + A E E+ P +E A A+ A+EA + QP
Sbjct: 582 EETTAE-EASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPP--- 637
Query: 1961 IESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPES 2020
++EA E QP E EV+ AE EA E + A EA E+Q E P
Sbjct: 638 -PAEEAPAEVQP--PPAEEAPAEVQPPPAE-EAPAEVQPPPAEEAPAEVQSLPAEETPIE 693
Query: 2021 DGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHP 2080
+ + A ++ E K P +D + E EA EV E P
Sbjct: 694 ETLAAVHSPPADDVPAEEASVDK----HSPPADLLLTEEF--PIGEASAEVSPPPSEQTP 747
Query: 2081 ESEDVDAQEAEGEAQPESEGVEAPE-----AEGEAQKAEGIEAPETEGEAQPESEGIEAP 2135
E E + + P+ G+ A + EGEA+ E + + ++G +AP
Sbjct: 748 EDEALVENVSTEFQSPQVAGIPAVKLGSVVLEGEAKFEEVSKINSVLKDLSNTNDG-QAP 806
Query: 2136 EAEGEA 2141
E E+
Sbjct: 807 TLEIES 812
Score = 56.6 bits (135), Expect = 3e-07
Identities = 105/487 (21%), Positives = 168/487 (34%), Gaps = 81/487 (16%)
Query: 1938 AEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES 1997
+E Q+ + + T + E ++E + E V E + +EA E
Sbjct: 53 SELQQTWTKRKHGQEMTSKSLQTDTIVEEKKEVKLVEETVVPEEKSADVREAAIELPESV 112
Query: 1998 EDVEAPEAEGEMQEAEEEAQ-------------PESDGVEAQPKSEGEEAQEV------E 2038
+DVE P +Q + +Q P + V+ + ++ E++ V
Sbjct: 113 QDVEIPPNIPSVQLKMDRSQQTSRTGYWTMMNIPPVEKVDKEQQTYFSESEIVVISRPDS 172
Query: 2039 GETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE----------------------AEG 2076
T+ E + +S G E Q A +E E
Sbjct: 173 SSTKSKEDALKHKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLLED 232
Query: 2077 EAHPESEDVDAQE-------AEGEAQPES-----EGVEAPEAEGEAQKAEGIEAPETEGE 2124
E E QE A E +P S ++ P E KAE A ET +
Sbjct: 233 ELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPRPAEETHVQ 292
Query: 2125 AQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE---GIEAQEAEEEAQPELEGVE 2181
QP +E E P+AE V+ Q E P E I+ AEE EL
Sbjct: 293 VQPSTE--ETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAEI 350
Query: 2182 APEAEGEAQPESEGIE--APEAEGEAQPELEG-VEAPEAEE---EAQPEPEGVETPEAEG 2235
P + E+ E E P AE EL G + +P A++ E QP P EA
Sbjct: 351 LPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAPA 410
Query: 2236 EAQPESEGETQGE-----KKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQ 2290
+ +P + ET + + +P+ + Q A E+ + E+ PT SP P +
Sbjct: 411 KVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPA---EEAPTEFQSP---LPKE 464
Query: 2291 RPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS 2350
+ ++ + D + RSP ++ T A + E +T+
Sbjct: 465 TTAEEASAEIQLLAA------TEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTA 518
Query: 2351 EQEEAPL 2357
E+ A +
Sbjct: 519 EEASAEI 525
Score = 46.2 bits (108), Expect = 4e-04
Identities = 81/319 (25%), Positives = 117/319 (36%), Gaps = 34/319 (10%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E AE E ++ E AE E L T+ + + + EET EE
Sbjct: 447 ETPAEEAPTEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHA 506
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIE----ETGGEG---LQEEGVQLEEVKEGPEGGL 1385
E VQ +ET E E L IE ET E L EE E E
Sbjct: 507 E--VQSPLAEETTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSA 564
Query: 1386 QGEALEEG-------LKEEGLPEEGSVHGQELS--EASSPDGKGSQEDDPVQEEEAGRAS 1436
+G ++EE EE EE S Q L+ EAS+ + + P +E A
Sbjct: 565 KGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQP 624
Query: 1437 ASAEPCPAEGTEEPTE--------PPSHLSETD---PSASERQSGSQLEPGLEKPPGATM 1485
AE PAE P E PP+ + + P A E + Q P E P
Sbjct: 625 PPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQS 684
Query: 1486 MGQEHTQAQPTQGAAERSSS---VACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELR 1542
+ E T + T A + A A++D +LL TE+ + ++ V+
Sbjct: 685 LPAEETPIEETLAAVHSPPADDVPAEEASVDKHSPPADLLL--TEEFPIGEASAEVSPPP 742
Query: 1543 ARWGLQDNDLLDQMAAELQ 1561
+ +D L++ ++ E Q
Sbjct: 743 SEQTPEDEALVENVSTEFQ 761
Score = 37.7 bits (86), Expect = 0.14
Identities = 55/272 (20%), Positives = 96/272 (35%), Gaps = 36/272 (13%)
Query: 1270 ATNEDEA------ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLE 1323
ATN +E R S Q L E+ ++EEV + +EG+ + + ++
Sbjct: 201 ATNSNEEIGQKNISRTSFTQETKKGPPVLLEDELREEVTVPVVQEGSAVKKVASAEIEPP 260
Query: 1324 ETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEG 1383
T+ + + E T + E +E Q++ E + V VK P
Sbjct: 261 STEKFPAKIQPPLVEEATAKAEPRPAEETHVQVQPSTEETPDAEAATAVAENSVKVQPPP 320
Query: 1384 GLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDP----------------- 1426
+ +E + + E S + L+E P + S ++P
Sbjct: 321 AEEAPLVEFPAEIQPPSAEESPSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVEL 380
Query: 1427 ---VQEEEAGRASASAEPCPAEGTEE----PTEPPS---HLSETDPSASE---RQSGSQL 1473
++ A +A +P PAEG E EPP+ L++ P E R+ +L
Sbjct: 381 LGEIRSPSAQKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEAREL 440
Query: 1474 EPGLEKPPGATMMGQEHTQAQPTQGAAERSSS 1505
+ A E P + AE +S+
Sbjct: 441 QLSTAMETPAEEAPTEFQSPLPKETTAEEASA 472
>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
Length = 686
Score = 124 bits (310), Expect = 1e-27
Identities = 138/467 (29%), Positives = 212/467 (45%), Gaps = 56/467 (11%)
Query: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895
EA E EG A P +G PE E GE + E PE A+ E P
Sbjct: 3 EAAEPEGVA-PGPQG--PPEVPAPLAERPGEPGAAGGEAEGPEGSEGAE------EAPRG 53
Query: 1896 EWEVQPESEGA--EAPEAE----KEAQPETESVEALETEGEDEPES--EGAEAQEAEEAA 1947
V+ G PEAE + A ETE+ E EG + P+ E + AQ+ E A+
Sbjct: 54 AAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAP-EGAEVPQGGEETSGAQQVEGAS 112
Query: 1948 QEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG 2007
Q +P E +E E+ A PE ++ E E + EG A E+ D + +AEG
Sbjct: 113 PGRGAQGEPRGEA--QREPEDSAAPERQE----EAEQRPEVPEGSASGEAGD--SVDAEG 164
Query: 2008 EMQEAEEEAQPESDGVEAQPK-SEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQE 2066
+ + E P D VEA+ + + +A+ G++ EG P D ++A ++ +
Sbjct: 165 PLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEG---PLGDNIQAEGPAGDSVD 221
Query: 2067 AEGEVQEAEGEAHPESEDVDAQEAEGEA----QPESEGVEAPEAEGEAQKAEG-----IE 2117
AEG V ++ P + VDA+ G++ P +GVEA G++ +AEG ++
Sbjct: 222 AEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMD 281
Query: 2118 APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ-PE 2176
A G A+ S G +G P++E +E A GE+ S G A +A EEA+ P
Sbjct: 282 AEGPAGRARRVS-GEPQQSGDGSLSPQAEAIEV--AAGESAGRSPGELAWDAAEEAEVPG 338
Query: 2177 LEGVE--AP-EAEGEAQPESEGIEAPEAEGEAQPELE-GVEAPEAEEEAQPEPEGVET-P 2231
++G E AP +A +A + G + GE + E E P EE A E E ++ P
Sbjct: 339 VKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSP 398
Query: 2232 EAE---GEAQPESEGET----QGEKKGSPQVSLGDGQSEEASESSSP 2271
E G A+PE++ +G +GS + + +G+ E+ E+S P
Sbjct: 399 HGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRRED-GEASEP 444
Score = 112 bits (281), Expect = 3e-24
Identities = 129/476 (27%), Positives = 198/476 (41%), Gaps = 57/476 (11%)
Query: 1767 AMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGG-QGS-GHEDNLQGEAAA---- 1820
A A E EG + AE+ GE + GE G +GS G E+ +G AA
Sbjct: 2 AEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAG 61
Query: 1821 GGDQDPGQSDGAEGIEAPEAEGEAQPES-EGVEAP---EAEGDAQEAEGEAQPESEDVEA 1876
GG D G A G E EA+ + EG E P E AQ+ EG +
Sbjct: 62 GGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQ--- 118
Query: 1877 PEAEGEAQPESEDVETPEAEWEVQ--PE-SEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
E GEAQ E ED PE + E + PE EG+ + EA E + +E EG P
Sbjct: 119 GEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEG---P 175
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ EA+ + +AEG P + ++++ P ++++A ++ +AEG
Sbjct: 176 AGDSVEAEGRVGDSVDAEG---PAGDSVDAEG------PLGDNIQAEGPAGDSVDAEGRV 226
Query: 1994 QPESEDVEAP-----EAEGEMQEAEEEAQPESDGVEAQ-PKSEGEEAQEVEGETQKTEGD 2047
+S D E P +AEG + ++ E P DGVEA P + EA+ G++ EG
Sbjct: 227 G-DSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGP 285
Query: 2048 AQPESDGVEAPEAEEEAQEAEGEVQEA-EGEAHPESEDVDAQEAEGEAQPESEGVEAPEA 2106
A A+ GE Q++ +G P++E ++ A GE+ S G A +A
Sbjct: 286 AG-------------RARRVSGEPQQSGDGSLSPQAEAIEV--AAGESAGRSPGELAWDA 330
Query: 2107 EGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEA 2166
EA+ G++ E ++ E +G Q E E ++ E E E
Sbjct: 331 AEEAE-VPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGG 389
Query: 2167 QEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+E ++ P E + G A+PE++ EG A+ E E+ +
Sbjct: 390 EEESPDSSPHGEA-----SRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGE 440
Score = 97.8 bits (242), Expect = 1e-19
Identities = 120/473 (25%), Positives = 185/473 (39%), Gaps = 64/473 (13%)
Query: 1648 GEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAE 1707
G EAEG E + + + G RGP EA + RG H + EA E
Sbjct: 35 GGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEA-------RGTRGAHGETEAEE 87
Query: 1708 VAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDA 1767
AP QG E G Q G G +G R ++P E A
Sbjct: 88 GAP-------EGAEVPQGGEET--SGAQQVEGASPGRGAQGEPRGEAQREP-----EDSA 133
Query: 1768 MAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPG 1827
+ +E E GS GEA G+ + G G DN++ E AG D
Sbjct: 134 APERQEEAEQRPEVPEGSASGEA---GDSVDAEGPLG-------DNIEAEGPAG---DSV 180
Query: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA-QPE 1886
+++G G ++ +AEG P + V+A GD +AEG P + V+A G++ E
Sbjct: 181 EAEGRVG-DSVDAEG---PAGDSVDAEGPLGDNIQAEG---PAGDSVDAEGRVGDSVDAE 233
Query: 1887 SEDVETPEAEWEVQPESE-GAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEE 1945
++ +AE V E G A + + P +SVEA + P + +A+
Sbjct: 234 GPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEA------EGPAGDSMDAEGPAG 287
Query: 1946 AAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEA 2005
A+ G+ Q Q + P++E +EV E+ G + E A EA
Sbjct: 288 RARRVSGEPQ--------QSGDGSLSPQAE-----AIEVAAGESAGRSPGELAWDAAEEA 334
Query: 2006 EGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQ 2065
E + EEA P +A G+ Q+ GE ++ + EA EEE+
Sbjct: 335 EVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESP 394
Query: 2066 EAEGEVQEAEGEAHPESEDVD--AQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116
++ + + G A PE++ + A+E E E+ V +GEA + +
Sbjct: 395 DSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRAL 447
Score = 72.8 bits (177), Expect = 4e-12
Identities = 120/472 (25%), Positives = 164/472 (34%), Gaps = 132/472 (27%)
Query: 2014 EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE 2073
E A+PE GV P+ E + E G A E++G E E EEA V+E
Sbjct: 3 EAAEPE--GVAPGPQGPPEVPAPL-AERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKE 59
Query: 2074 AEG---EAHPESEDVDAQEAEGEAQPES---EGVEAPEAEGEAQKAEGIEAPETEGEAQP 2127
A G + PE+E + A GE + E EG E P+ E A+ +E AQ
Sbjct: 60 AGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQG 119
Query: 2128 ESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE-SEGIEAQEAEEEAQPELEGVEAPEAE 2186
E P E + +PE + E E +PE EG + EA + E + EAE
Sbjct: 120 E------PRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAE 173
Query: 2187 GEA--QPESEG-------IEAP---------------EAEGEAQPELEG---------VE 2213
G A E+EG E P +AEG A ++ E
Sbjct: 174 GPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAE 233
Query: 2214 AP------------EAEEEAQPEPEGVE-------TPEAEGEAQPESEGETQGEK----K 2250
P ++ E P +GVE + EAEG A + E +
Sbjct: 234 GPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVS 293
Query: 2251 GSPQVSLGDGQSEEASES----------------------SSPVPEDRPTPPPSPG---- 2284
G PQ S GDG +E+ + VP + + +PG
Sbjct: 294 GEPQQS-GDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARA 352
Query: 2285 -------GDTPHQRPGS-----QTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTG 2332
GD P Q PG + P R E + G+ SPD+
Sbjct: 353 DAGEDRVGDGPQQEPGEDEERRERSPEGPR------------EEEAAGGEEESPDS---- 396
Query: 2333 TPHAERKATRMYPESSTSEQ--EEAPL---GSRTPEQGASEGYDLQEDQALG 2379
+PH E PE+ S EE P G G E + E +ALG
Sbjct: 397 SPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALG 448
Score = 51.2 bits (121), Expect = 1e-05
Identities = 110/477 (23%), Positives = 158/477 (33%), Gaps = 81/477 (16%)
Query: 554 GCPGKARAETSQQEASEGGDPA---SPALSLSSLRSDDLQAETQGQGTEQATGAAVTREP 610
G PG A E E SEG + A + A+ + D E + +GT A G
Sbjct: 29 GEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHG------- 81
Query: 611 LVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHY 670
++E P Q G+ + + +SPG G +G PR
Sbjct: 82 ---------ETEAEEGAPEGAEVPQGGEE---TSGAQQVEGASPGRGA---QGEPRGEAQ 126
Query: 671 RK--DTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRP--PSSGS 726
R+ D+ +P +Q P PE GS +G S N+ P+ S
Sbjct: 127 REPEDSAAPERQEEAEQRPEVPE-------GSASGEAGDSVDAEGPLGDNIEAEGPAGDS 179
Query: 727 LPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGD---AGSRTCSPAPIPPHTSDS 783
+ ++ +G S PA S G N + G AGD A R DS
Sbjct: 180 VEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDS 239
Query: 784 CSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQR-GPS 842
G EA D ++ G P +V S PA A+R
Sbjct: 240 VDAEGRVGDSVEAGDPAGDG----VEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGE 295
Query: 843 PEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQ---PGPTP 899
P+ S G PQ + ++ +S R PG + + PG
Sbjct: 296 PQQSG----------DGSLSPQAEAIEV----AAGESAGRSPGELAWDAAEEAEVPGVKG 341
Query: 900 SPGPNSGASRRSSASQGAGSR-----GLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPE 954
S G +R + G G EE+ RS GP+ +E A G S P SSP
Sbjct: 342 SEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEES--PDSSPH 399
Query: 955 AVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQ 1011
E E ++ LA+E GP G+ + G E +A +
Sbjct: 400 G---EASRGAAEPEAQLSNHLAEE----------GPAEGSGEAARVNGRREDGEASE 443
Score = 46.6 bits (109), Expect = 3e-04
Identities = 127/526 (24%), Positives = 175/526 (33%), Gaps = 82/526 (15%)
Query: 939 EASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDH 998
E GV+P P+ PE V L P EP GAAGG GPE G +
Sbjct: 6 EPEGVAPG--PQGPPE--VPAPLAERPGEP------------GAAGGEAEGPEGSEGAEE 49
Query: 999 SLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGA-APEGVSEAPAE 1057
+ G +AG G P + PE E + ++ EG P+GA P+G E
Sbjct: 50 APRGAAAVKEAG----GGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGA 105
Query: 1058 AGADREAPA-GCRVSLR----------ALPGRVSASTQIMRALMGSKQGRPSSVPEVSRP 1106
+ +P G + R A P R + Q GS G + P
Sbjct: 106 QQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGP 165
Query: 1107 MARRLSCSAGALITCLASLQLFEE-DLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGE 1165
+ + A + A ++ + D PA + P + +
Sbjct: 166 LGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGP--------AG 217
Query: 1166 DQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVT 1225
D +D A +G E + VD G S E+ P A DG
Sbjct: 218 DSVD----------AEGRVGDSVDAEG---PAGDSVDAEGRVGDSVEAGDP-AGDGVEAG 263
Query: 1226 QGTELPLKTSNQRPDSRTYESPGD----LENQQQCCFPTFLNARACACATNEDEAERDSE 1281
++ DS E P + + Q L+ +A A E+ S
Sbjct: 264 VPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSP 323
Query: 1282 EQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEET 1341
+ A E+ V+ EE G E+ V + + E G EE
Sbjct: 324 GELAWDAAEEAEVPGVKGS---EEAAPGDARADAGEDRVG-DGPQQEPGEDEE------R 373
Query: 1342 KETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEG---PEGGLQGEALEEGLKEEG 1398
+E EG +EEEA GGE + E G PE L EEG EG
Sbjct: 374 RERSPEGPREEEA-------AGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEG-PAEG 425
Query: 1399 LPEEGSVHG-QELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCP 1443
E V+G +E EAS P G QE D +AG S CP
Sbjct: 426 SGEAARVNGRREDGEASEPRALG-QEHDITLFVKAGYDGESIGNCP 470
Score = 43.9 bits (102), Expect = 0.002
Identities = 70/257 (27%), Positives = 89/257 (34%), Gaps = 45/257 (17%)
Query: 854 PTPPRGRPCP-QRRSSSCGSTGSSHQSTARGPGGSP-----QEGTRQPGPTPSPGPNSGA 907
P P P P R G+ G A GP GS G GP+ G
Sbjct: 14 PQGPPEVPAPLAERPGEPGAAGGE----AEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGP 69
Query: 908 SRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEAS------GVSPSSLPRSSPEA-VVREW 960
+ ++GA +EE PQG EE S G SP + P RE
Sbjct: 70 EAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREP 129
Query: 961 LDNIPEEPILMTYELADETTGAAGGGLRGPEVDPGDDHSLEG-LGEPAQAGQQSLEGDPG 1019
D+ E + + G+A G + GD EG LG+ +A EG G
Sbjct: 130 EDSAAPERQEEAEQRPEVPEGSASG-------EAGDSVDAEGPLGDNIEA-----EGPAG 177
Query: 1020 QDPEPEGALLGSSDTGPQSGEGVP---------QGAAPEGVS-EAPAEAG--ADREAPAG 1067
E EG + S D +G+ V Q P G S +A G D E PAG
Sbjct: 178 DSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAG 237
Query: 1068 CRVSLRALPGRVSASTQ 1084
V GRV S +
Sbjct: 238 DSVDAE---GRVGDSVE 251
Score = 39.7 bits (91), Expect = 0.036
Identities = 53/212 (25%), Positives = 75/212 (35%), Gaps = 14/212 (6%)
Query: 878 QSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGA--GSRGLSEEKTLRSGGGPQ 935
+ A GP G P+ PG G + S+GA RG + K GG +
Sbjct: 8 EGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDR 67
Query: 936 GQE-EASGV----SPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGP 990
G E EA G + +PE E E E A GA G
Sbjct: 68 GPEAEARGTRGAHGETEAEEGAPEGA--EVPQGGEETSGAQQVEGASPGRGAQGEPRGEA 125
Query: 991 EVDPGDDHSLEGLGEPAQ---AGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGV-PQGA 1046
+ +P D + E E Q + S G+ G + EG L + + +G+ V +G
Sbjct: 126 QREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGR 185
Query: 1047 APEGV-SEAPAEAGADREAPAGCRVSLRALPG 1077
+ V +E PA D E P G + G
Sbjct: 186 VGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAG 217
Score = 39.3 bits (90), Expect = 0.047
Identities = 38/142 (26%), Positives = 58/142 (40%), Gaps = 17/142 (11%)
Query: 444 GRERCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQ-IGAERKAGGSLGED 502
GR S D+ PA + EG +S DGV++ P+ + AE AG S+ +
Sbjct: 224 GRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAE 283
Query: 503 PGLCIDGAGLGGPEQGG--RLTPRARSEEGASSDSSASTGSHEGSSEWG----------- 549
G P+Q G L+P+A + E A+ +S+ G G W
Sbjct: 284 GPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESA---GRSPGELAWDAAEEAEVPGVK 340
Query: 550 GRPQGCPGKARAETSQQEASEG 571
G + PG ARA+ + +G
Sbjct: 341 GSEEAAPGDARADAGEDRVGDG 362
Score = 38.9 bits (89), Expect = 0.061
Identities = 67/290 (23%), Positives = 105/290 (36%), Gaps = 34/290 (11%)
Query: 1235 SNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAER---DSEEQRASSNLEQ 1291
+ QRP+ + G+ + P N A A + EAE DS + +
Sbjct: 141 AEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSV 200
Query: 1292 LAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLE-------ETKET 1344
AE + + +Q E G G+ + E ++ ++ EG + V E E +
Sbjct: 201 DAEGPLGDNIQAE----GPAGDSVDAEG-RVGDSVDAEGPAGDSVDAEGRVGDSVEAGDP 255
Query: 1345 EGEGQQEEEAQLEEIEETG--GEGLQEEGVQLE------EVKEGPEGGL--QGEALEEGL 1394
G+G + + +E G G+ + EG E ++ +G L Q EA+E
Sbjct: 256 AGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAA 315
Query: 1395 KEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASA-EPCPAEGTEEPTEP 1453
E G + EA P KGS+E P G A A A E +G ++
Sbjct: 316 GESAGRSPGELAWDAAEEAEVPGVKGSEEAAP------GDARADAGEDRVGDGPQQEPGE 369
Query: 1454 PSHLSETDPSA--SERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAE 1501
E P E +G + E P G G +AQ + AE
Sbjct: 370 DEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAE 419
Score = 38.5 bits (88), Expect = 0.080
Identities = 59/234 (25%), Positives = 89/234 (38%), Gaps = 38/234 (16%)
Query: 1276 AERDSEEQRASSNLE-----QLAENTVQEEVQLEETKEGTEGEGLQEEAVQLE----ETK 1326
AER E A E + AE + ++E G G + EA ET+
Sbjct: 25 AERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETE 84
Query: 1327 TEEGLQEEGVQLEETKETEG-------------EGQQEEEAQLEEIEETGGEGLQEEGVQ 1373
EEG E + +ET G +G+ EAQ E E++ QEE Q
Sbjct: 85 AEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREP-EDSAAPERQEEAEQ 143
Query: 1374 LEEVKEGPEGGLQGEALE-EGLKEEGLPEEG----SVHGQ----ELSEASSPDGKGSQED 1424
EV EG G G++++ EG + + EG SV + + +A P G +
Sbjct: 144 RPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAE 203
Query: 1425 DPVQE--EEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPG 1476
P+ + + G A S + G E P+ D +E + G +E G
Sbjct: 204 GPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPA----GDSVDAEGRVGDSVEAG 253
Score = 37.7 bits (86), Expect = 0.14
Identities = 57/245 (23%), Positives = 81/245 (33%), Gaps = 19/245 (7%)
Query: 396 GRGGQPGPKYEIWTNPLHASQGERVAARKRWGLAQHVRCSGLWGHGTAGRERCSQ--DSA 453
GRG Q P+ E P ++ ER ++ SG G ++
Sbjct: 114 GRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAE 173
Query: 454 SPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQ-IGAERKAGGSLGEDP--GLCIDGA 510
PA + EG +S D VD+ P I AE AG S+ + G +D
Sbjct: 174 GPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAE 233
Query: 511 GLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQEASE 570
G G EG DS G G G P G +A +E
Sbjct: 234 GPAGDSVDA---------EGRVGDS-VEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAE 283
Query: 571 GGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPST 630
G + +S +S D Q + E A G + R P L +WD+ + P
Sbjct: 284 GPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGEL----AWDAAEEAEVPGV 339
Query: 631 CTSSQ 635
S +
Sbjct: 340 KGSEE 344
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 122 bits (307), Expect = 3e-27
Identities = 255/1073 (23%), Positives = 405/1073 (37%), Gaps = 171/1073 (15%)
Query: 1312 GEGLQEEAVQLEET-KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEE 1370
GE +E+ + T K EE L+ E E + E GQ +EE +E G E ++E
Sbjct: 223 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAES-GQA-----VEECKEEGEEKQEKE 276
Query: 1371 GVQLEEVKEGPEGGLQGEALEEGLKE--EGLPEEGSVHGQELSEASSPDGKGSQEDDPVQ 1428
+ E P G ++ + G ++ S + E + + K QE + V
Sbjct: 277 PSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVD 336
Query: 1429 EEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSA--------SERQSGSQLEPGLEKP 1480
EE G+A ++E A P EP E SA SE Q P EKP
Sbjct: 337 TEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKP 396
Query: 1481 -PGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
P AT + E + + AE + VS + ++TE+
Sbjct: 397 APLATEVFDEKIEVHQEEVVAE---------------VHVSTVEERTEE--------QKT 433
Query: 1540 ELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGR---------AGRMVLEP 1590
E+ G + L +M AE Q+ A+ ++ K + + G VL
Sbjct: 434 EVEETAGSVPAEELVEMDAEPQE--AEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSK 491
Query: 1591 PREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEE 1650
P E + E+ + + Q R +++G F+ + GL LS + G + G +
Sbjct: 492 PPEGVVSEVEMLSSQERMKVQGSPLKKLFT--STGLKKLSGKKQK--------GKRGGGD 541
Query: 1651 AEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGE-HTDGEAAEVA 1709
E E A SP S + G + E + L++ E DGEA E A
Sbjct: 542 EESGEHTQVPA-----DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGA 596
Query: 1710 PGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDA-- 1767
+D R ++ V + + L++ K L E A
Sbjct: 597 T----SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASE 652
Query: 1768 MAQEREGKTHNS---------ETSAGSE----LGEAEQEGEGISERGETGG--------- 1805
M +E +G +TS E +G +++ S E GG
Sbjct: 653 MQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQ 712
Query: 1806 ----QGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEA----E 1857
G E G A + DPGQ G +PE G + E EGV E+
Sbjct: 713 KADEAGKDKETGTDGILAGSQEHDPGQ-----GSSSPEQAG-SPTEGEGVSTWESFKRLV 766
Query: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEW-----------EVQPESEGA 1906
++++ + + +SED A + P++E + E W + +P+ +
Sbjct: 767 TPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGK--EESWVSIKKFIPGRRKKRPDGKQE 824
Query: 1907 EAPEAE---KEAQPETESVEALETEGE-DEPESEGAEAQEAEEAAQEAEGQTQPE-SEVI 1961
+AP + A + V A+ E D E E EAQ+A+++A++ E + E S+ +
Sbjct: 825 QAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL 884
Query: 1962 ESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG-----EMQEAEEEA 2016
+ A ++ A + +E + + +E +E EAE E+ E E A
Sbjct: 885 SESQVHMMAAAVADGTRAATI-IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIA 943
Query: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES-------------DGVEAPEAEEE 2063
+ E V +P E EA+ G+T +E + PE+ +G EA A EE
Sbjct: 944 EEEPPTV-TEPLPENREAR---GDTVVSEAELTPEAVTAAETAGPLGAEEGTEA-SAAEE 998
Query: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI-EAPETE 2122
E V + E QE EG P+ E E E AE + E +
Sbjct: 999 TTEMVSAVSQLTDSPDTTEEATPVQEVEG-GVPDIEEQERRTQEVLQAVAEKVKEESQLP 1057
Query: 2123 GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEE--AQPELEGV 2180
G PE + P EA+ E EA + E + ++AQEA+ E Q ++ G
Sbjct: 1058 GTGGPED--VLQPVQRAEAERPEEQAEASGLKKETDVVLK-VDAQEAKTEPFTQGKVVGQ 1114
Query: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPE-LEGVEAPEAEEEAQPEPEGVETP---EAEGE 2236
PE+ +A +E IE+ E Q E L GV++ E E P+ VETP E +G
Sbjct: 1115 TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGS 1174
Query: 2237 ---AQPESEGETQGEK----KGSPQVSLGDGQSEEASESSSPVPEDRPTPPPS 2282
A ++ G TQ ++ +V+ G QS + P ++RP P S
Sbjct: 1175 TPVADFDAPGTTQKDEIVEIHEENEVASGT-QSGGTEAEAVPAQKERPPAPSS 1226
Score = 100 bits (249), Expect = 2e-20
Identities = 151/694 (21%), Positives = 263/694 (37%), Gaps = 90/694 (12%)
Query: 1744 EDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE-----QEGEGIS 1798
++GEG+ KDP LG E + E + T E + E AE + G+ +
Sbjct: 204 DEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVE 263
Query: 1799 ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEA---------QPESE 1849
E E G + E + E+ P S+ + +G A +P+ +
Sbjct: 264 ECKEEGEEKQEKEPSKSAESPT----SPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKED 319
Query: 1850 GVEAPEAEGDAQ------EAEGEAQPESEDVEAPE-------AEGEAQP----ESEDVET 1892
VEA E + + + E +G+A+ SE + A E AE +P E E VE
Sbjct: 320 EVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVEL 379
Query: 1893 PEAEWEVQPESEGAEAPEAEKEAQPETESV-EALETEGEDEPE----SEGAEAQEAEEAA 1947
P E + G++ P EK A TE E +E E+ S E E ++
Sbjct: 380 PSEE-----QVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTE 434
Query: 1948 QEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE-AEGEAQPESEDVEAPEAE 2006
E + P E++E +EA+P E V+ E V ++ +G E V + E
Sbjct: 435 VEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPE 494
Query: 2007 GEMQEAEEEAQPESDGVEAQPKSE---GEEAQEVEGETQKTEGDAQPESDG--VEAPEAE 2061
G + E E + E V+ P + +++ G+ QK + E G + P
Sbjct: 495 GVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADS 554
Query: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPET 2121
++QE + A PE E ++ E Q + E E ++GE +K EG+ +
Sbjct: 555 PDSQEEQKGESSASSPEEPE-EITCLEKGLAEVQQDGEAEEGATSDGE-KKREGVTPWAS 612
Query: 2122 EGEAQPESEGIEAPEAEGEAQPESEGVEA------QDAEGEAQPESEGIEAQEAEEEAQP 2175
+ + + P +E + + E + V++ + E Q E +G + EE +
Sbjct: 613 FKKMVTPKKRVRRP-SESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKR 671
Query: 2176 ELE---GVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPE 2232
+++ EA G ++ + + + EG P+ G + +A+E + + G +
Sbjct: 672 KVDTSVSWEALICVGSSKKRARRGSSSDEEG--GPKAMGGDHQKADEAGKDKETGTDGIL 729
Query: 2233 AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPE-------DRPTPPPSPGG 2285
A + +G + E+ GSP + G+G S S P + + G
Sbjct: 730 AGSQEHDPGQGSSSPEQAGSP--TEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGS 787
Query: 2286 DTPHQRPGSQTGPSSSRASSWGNC-----WQKDSENDHVLGDTRSPDAKSTGTPHAERKA 2340
H P ++ G + SW + ++ D DA TG +
Sbjct: 788 GVEHSTPDTEPG----KEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDV 843
Query: 2341 TRMYP-------ESSTSEQEEAPLGSRTPEQGAS 2367
+ P E E ++A + PEQ A+
Sbjct: 844 PAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAA 877
Score = 92.8 bits (229), Expect = 4e-18
Identities = 239/1137 (21%), Positives = 407/1137 (35%), Gaps = 144/1137 (12%)
Query: 1233 KTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLE-Q 1291
KTS ++P E+ + Q+ T + +A + +E+ ++ A S E +
Sbjct: 310 KTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR 369
Query: 1292 LAENTVQEEVQLEETKEGTEG------------------EGLQEEAV-QLEETKTEEGLQ 1332
L+ + E+ EE G++G E QEE V ++ + EE +
Sbjct: 370 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 429
Query: 1333 EEGVQLEETK-ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
E+ ++EET E E +A+ +E E +E V+L+E E QG L
Sbjct: 430 EQKTEVEETAGSVPAEELVEMDAEPQEAEPA------KELVKLKETCVSGEDPTQGADLS 483
Query: 1392 EGLKEEGLPEEGSVHGQE-LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP 1450
K P EG V E LS +GS + S + G +E
Sbjct: 484 PDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEE 543
Query: 1451 TEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSA 1510
+ + + P + E Q G E+P T + + + Q A E ++S
Sbjct: 544 SGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKK 603
Query: 1511 ALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQD 1570
P W S T K + + + E + D + + A +Q+
Sbjct: 604 REGVTP-WASFKKMVTPKKRVRRPSESDKE-------DELDKVKSATLSSTESTASEMQE 655
Query: 1571 STKRELQKLQGRAGRMVLEPPREALTG----ELLLQTQQRRHRLRGLRNLSAFSERTLGL 1626
K +++ + EP R+ T L+ ++ RG + + +G
Sbjct: 656 EMKGSVEEPKPE------EPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG 709
Query: 1627 -----------------GPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSP 1669
G L+ + E +P ++ Q G EGE E+ ++ V+P
Sbjct: 710 DHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES-FKRLVTP 768
Query: 1670 MSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGG 1729
++ ++E + G + + PGK + + + + G
Sbjct: 769 RKK------SKSKLEEKSE-----DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKK 817
Query: 1730 LGPGLS-QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQER----------EGKTHN 1778
G Q P D G G + D + +E DA+ +E+ E
Sbjct: 818 RPDGKQEQAPVEDAGPTGANED--DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 875
Query: 1779 SETSAGSELGEAEQE------GEG------ISERGETGGQGSGHEDNLQGEAAAGGDQDP 1826
+ T EL E++ +G I ER + S E Q EA A +
Sbjct: 876 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEE 935
Query: 1827 GQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE--AQ 1884
E P E PE+ EA GD +E E PE+ V A E G A+
Sbjct: 936 VLEREVIAEEEPPTVTEPLPENR-----EARGDTVVSEAELTPEA--VTAAETAGPLGAE 988
Query: 1885 PESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
+E E V S+ ++P+ +EA P E + E E ++ AE
Sbjct: 989 EGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAE 1048
Query: 1945 EAAQEAE--GQTQPESEVIESQEAEEEAQPESEDVEALEVE------VETQEAE------ 1990
+ +E++ G PE + Q AE E E + L+ E V+ QEA+
Sbjct: 1049 KVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQ 1108
Query: 1991 ----GEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEG 2046
G+ PES + +AP+ ++ +E +++ + E Q + ++ +T
Sbjct: 1109 GKVVGQTTPESFE-KAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPT 1167
Query: 2047 DAQPESDGVEAPEAEEEAQEAEGEVQEAE-GEAHPESEDVDAQEA---EGEAQP-ESEGV 2101
D+ E+DG P A+ +A G Q+ E E H E+E ++ E EA P + E
Sbjct: 1168 DS--ETDG-STPVAD---FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERP 1221
Query: 2102 EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPES 2161
AP + ++ + E E + +E + + E + D + + P
Sbjct: 1222 PAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFF 1281
Query: 2162 EGIEAQ-EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE----APE 2216
EG+E + E A + EG + E + +A E + A+ VE
Sbjct: 1282 EGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV 1341
Query: 2217 AEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273
E+ + EP V + E E E + + V + DG E +S SP P
Sbjct: 1342 EREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPP 1398
Score = 80.9 bits (198), Expect = 1e-14
Identities = 149/675 (22%), Positives = 243/675 (36%), Gaps = 105/675 (15%)
Query: 1783 AGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEG 1842
+ +E EQ EG S E G G EAA DP + + + G
Sbjct: 5 SSTEQRSPEQPPEGSSTPAEPEPSGGGPS----AEAAPDTTADPAIAASDPATKLLQKNG 60
Query: 1843 EAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPE 1902
+ G A++ E Q + + G+ S++ E Q +
Sbjct: 61 QLST---------INGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRD 111
Query: 1903 SEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE 1962
SE +++KE ++ V + +G++E + +E +E T+ ++ I
Sbjct: 112 SEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIG 171
Query: 1963 SQE----------AEEEAQPESEDVEALEVEVETQE------------------AEGEAQ 1994
++ +++ + + V+ L V+ + E A E++
Sbjct: 172 FKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESE 231
Query: 1995 PESEDVEAPEAEGEMQEAEEEAQPESDGVEA--QPKSEGEEAQEVE-------------- 2038
P+ + E PE + +++ E P ++ +A + K EGEE QE E
Sbjct: 232 PK-QSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTS 290
Query: 2039 --GETQK---TEGDA---------QPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESED 2084
G T K T+G A +P+ D VEA E ++E QE E E +G+A SE
Sbjct: 291 ETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKE-QEPEKVDTEEDGKAEVASEK 349
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-----GIEAPEAEG 2139
+ A E + Q +E P E +K E + G P E E + +
Sbjct: 350 LTASE-QAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKI 408
Query: 2140 EAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAP 2199
E E E + E + E + E +E P E VE EA+P E ++
Sbjct: 409 EVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSV-PAEELVEMDAEPQEAEPAKELVKLK 467
Query: 2200 EAEGEAQPELEGVEAPEAEEEAQPEPEGV--ETPEAEGEAQPESEGE-------TQGEKK 2250
E + +G + E+ PEGV E + + + +G + G KK
Sbjct: 468 ETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKK 527
Query: 2251 GSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNC 2309
S + G G +E S + VP D P G++ P P G
Sbjct: 528 LSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEE---PEEITCLEKGLA 584
Query: 2310 -WQKDSENDHVLGDTRSPDAKSTG-TPHAE-------RKATRMYPESSTSEQEEAPLGSR 2360
Q+D E + G T + K G TP A +K R P S E E + S
Sbjct: 585 EVQQDGEAEE--GATSDGEKKREGVTPWASFKKMVTPKKRVRR-PSESDKEDELDKVKSA 641
Query: 2361 TPEQGASEGYDLQED 2375
T S ++QE+
Sbjct: 642 TLSSTESTASEMQEE 656
Score = 76.6 bits (187), Expect = 3e-13
Identities = 184/887 (20%), Positives = 309/887 (34%), Gaps = 143/887 (16%)
Query: 1292 LAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEG-LQEEGVQLEETKETEGEGQQ 1350
L E ++ EV EE + T E L E +T E L E V ET G +
Sbjct: 932 LTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEG 990
Query: 1351 EEEAQLEEIEE--------TGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEE 1402
E + EE E T EE ++EV EGG+ +E +E L
Sbjct: 991 TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV----EGGVPDIEEQERRTQEVL--- 1043
Query: 1403 GSVHGQELSEASSPDGKGSQED--DPVQEEEAGRASASAEPCPAEGTEEPTEP----PSH 1456
+++ E S G G ED PVQ EA R AE A G ++ T+ +
Sbjct: 1044 -QAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAE---ASGLKKETDVVLKVDAQ 1099
Query: 1457 LSETDPSASERQSGSQLEPGLEKPPGATMMGQEH---TQAQPTQGAAERSSSVACSAALD 1513
++T+P + G EK P T + T Q A +S + A+
Sbjct: 1100 EAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIP 1159
Query: 1514 CDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLD------------QMAAELQ 1561
D + +T ++ VA+ A Q +++++ E +
Sbjct: 1160 PDSV-------ETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1212
Query: 1562 QDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSE 1621
AQ+ + + + +E E E+ ++T + G + +++
Sbjct: 1213 AVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYAD 1272
Query: 1622 RTLGLGP----LSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMG 1677
P L +++ +S +++ + EG E C KK + ++
Sbjct: 1273 EKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAEC-----KKDDALELQSHAK 1327
Query: 1678 ATRGPIKEAFDLQQILQRKRGE--HTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLS 1735
+ P++ +Q ++ E H + E E T ++ S + +Q + G
Sbjct: 1328 SPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAK 1387
Query: 1736 QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGE 1795
+ + EGS P LG+ E + + + +A +E + E
Sbjct: 1388 EVSSL------EGSP------PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETA 1435
Query: 1796 GISERGETGGQGSGH--------EDNLQGEAAAGGDQDP--------------------G 1827
I E GET H E N A G D P G
Sbjct: 1436 NILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKG 1495
Query: 1828 QSDGAEGIEAPEAEGEAQPESE-----------GVEAPEAEGDAQEAEGEAQP------- 1869
S EG + + ++ E +E E E E E ++
Sbjct: 1496 LSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQ 1555
Query: 1870 -------ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESV 1922
+E+ E Q ++ ++ + + E EG E + ++ P T +
Sbjct: 1556 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1615
Query: 1923 EALETEGEDEPESE-GAEAQEAEEAAQ--EAEGQT----QPESEVIESQE----AEEEAQ 1971
E E+ + S+ + EA E E EG T Q E V+ S+E A ++
Sbjct: 1616 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSV 1675
Query: 1972 PESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEM---QEAEEEAQPESDGVEAQPK 2028
PE + L +E E + + +DV+ PE + +A ES +
Sbjct: 1676 PEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQ 1735
Query: 2029 SEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAE 2075
E E+AQEVE + EG ESD P+A+EE Q+ E E ++E
Sbjct: 1736 KEKEDAQEVELQ----EGKVHSESDKAITPQAQEELQKQERESAKSE 1778
Score = 69.7 bits (169), Expect = 3e-11
Identities = 253/1209 (20%), Positives = 433/1209 (35%), Gaps = 199/1209 (16%)
Query: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQL---EETKEGTEGEGLQEEAVQLEETK 1326
A+ E + S E+ ++ + +V E + K G EE K
Sbjct: 650 ASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG----GPK 705
Query: 1327 TEEGLQEEGVQLEETKETEGEG-----QQEEEAQLEEIEETGGEGLQEEGVQLEE----- 1376
G ++ + + KET +G Q+ + Q E G + EGV E
Sbjct: 706 AMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRL 765
Query: 1377 ----------VKEGPEGGLQGEALEEGLKE-EGLPEEGSVHGQEL---SEASSPDGKGSQ 1422
++E E + G +E + E EE V ++ PDGK Q
Sbjct: 766 VTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK--Q 823
Query: 1423 EDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPP- 1481
E PV E+AG A+ + ++ P P LSE D E+ Q + E+P
Sbjct: 824 EQAPV--EDAGPTGANEDD-----SDVPAVVP--LSEYDAVEREKMEAQQAQKSAEQPEQ 874
Query: 1482 -GATMMGQEHTQAQP-TQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
AT + +E +++Q AA + A + + P W+S A + +
Sbjct: 875 KAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS-----------ASVTEPLE 923
Query: 1540 ELRARWGLQDNDLLDQ--MAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTG 1597
++ A L ++L++ +A E V + L ++ + + A E EA+T
Sbjct: 924 QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA-----ELTPEAVTA 978
Query: 1598 ELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEG---- 1653
+T G SA E T + +S L D P T + +E EG
Sbjct: 979 A---ETAGPLGAEEGTE-ASAAEETTEMVSAVS-QLTDSP--DTTEEATPVQEVEGGVPD 1031
Query: 1654 --EEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPG 1711
E+ + ++ + ++ + T GP D+ Q +QR E + E AE +
Sbjct: 1032 IEEQERRTQEVLQAVAEKVKEESQLPGTGGPE----DVLQPVQRAEAERPE-EQAEASGL 1086
Query: 1712 KTHTDPTSTRTVQGAE----------GGLGP-GLSQGPGVDEGEDGEGSQRLNRDKDPKL 1760
K TD Q A+ G P + P V E E S+ + + L
Sbjct: 1087 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESI--ESSELVTTCQAETL 1144
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGE----AEQEGEGISERGETGGQGSGHEDNLQG 1816
+ M E+ + ET SE A+ + G +++ E HE+N
Sbjct: 1145 AGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIV---EIHEEN--- 1198
Query: 1817 EAAAGGDQDPGQSDGAEGIEAPEAEGEAQP-------ESEGVEAPEAEGDAQEAEGEAQP 1869
E A+G QS G E EA A+ E P + E E + E + + E
Sbjct: 1199 EVASGT-----QSGGTEA-EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1252
Query: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAP-EAEKEAQPETESVEALETE 1928
E+ + + + + D +T + P EG E + E + AL+ E
Sbjct: 1253 ETVSILSKTEGTQEADQYADEKTKDV-----PFFEGLEGSIDTGITVSREKVTEVALKGE 1307
Query: 1929 GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE 1988
G +E E + +A E + A+ + E V++ + + EA+P + E LE E
Sbjct: 1308 GTEEAECKKDDALELQSHAKSPPSPVEREM-VVQVEREKTEAEPTHVNEEKLEHETAVTV 1366
Query: 1989 AEGEAQPESEDVEAPEAEGEMQEAEEEAQP--------------ESDGVEA--------- 2025
+E ++ + V P +G + + E P + EA
Sbjct: 1367 SEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAE 1426
Query: 2026 QPKSEGEEAQEVE-GETQKTEGD----------------AQPESDGVEA-PEAEEE---- 2063
+ K GE A +E GET + G A P D V P+ + +
Sbjct: 1427 EEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPV 1486
Query: 2064 ---AQEAEGEVQEAEGEAHP----ESEDVDAQEAEGEAQPESEGVEAPEAEG-------- 2108
A +G + EGE +S++VD Q A E + S +E E E
Sbjct: 1487 IVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKV-SVAIEDLEPENGILELETK 1545
Query: 2109 EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE 2168
++ + I + + E E +E + Q ++QDA E E EG E Q
Sbjct: 1546 SSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQET--EKEGEEPQA 1603
Query: 2169 AEEEAQPELEGVEAPE--AEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226
+ ++ P E E A G+A + + +E E+EG + + E P
Sbjct: 1604 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1663
Query: 2227 GVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGD 2286
E A ++ PE +G ++ + + + E+ + P ++ G
Sbjct: 1664 EEEGGGAGTKSVPEDDGHALLAERIEKSL-VEPKEDEKGDDVDDPENQNSALADTDASGG 1722
Query: 2287 TPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPE 2346
+ P + GP ++D++ + ++ TP A+ + + E
Sbjct: 1723 LTKESPDT-NGPKQKE--------KEDAQEVELQEGKVHSESDKAITPQAQEELQKQERE 1773
Query: 2347 SSTSEQEEA 2355
S+ SE E+
Sbjct: 1774 SAKSELTES 1782
Score = 48.9 bits (115), Expect = 6e-05
Identities = 222/1092 (20%), Positives = 374/1092 (34%), Gaps = 151/1092 (13%)
Query: 492 ERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGR 551
E AG +DP L GAG ++ + EE + S + S S G
Sbjct: 207 EGAAGAGDHKDPSL---GAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAES--GQA 261
Query: 552 PQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQG-QGTEQATGAAVTREP 610
+ C + + ++ + P SP S + S + TQG G + T +E
Sbjct: 262 VEECKEEGEEKQEKEPSKSAESPTSPVTSETG--STFKKFFTQGWAGWRKKTSFRKPKED 319
Query: 611 LVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSR---ASAMSSPSSPGLGRVAPRGHPRH 667
V + E P + + G+ S AS + P P PR +
Sbjct: 320 EVEASEKKKEQE-----PEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY 374
Query: 668 SHYRKDTHSPLDSSV--TKQVPRP------PERRRACQDGSVPRYSGSSSSTRTQASGNL 719
+ + S +++ P P E+ Q+ V S+ RT+
Sbjct: 375 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTE 434
Query: 720 RPPSSGSLPSQDL--LGTSSATVTPA-----VHSDFVSGVSPHNAPSAGWAGDAGSRTCS 772
++GS+P+++L + PA + VSG P A + D +
Sbjct: 435 VEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDP--TQGADLSPDEKVLSKP 492
Query: 773 PAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVG----PHRSHCCSQ 828
P + S+ G + S+ L G+ ++G G H
Sbjct: 493 PEGVVSEVEMLSSQERMKVQGSPLKKL-FTSTGLKKLSGKKQKGKRGGGDEESGEHTQVP 551
Query: 829 PGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSP 888
+ +QE Q+G S +S P P C ++ + G + + A G
Sbjct: 552 ADSPDSQEEQKGESSASS-------PEEPEEITCLEKGLAEVQQDGEAEEG-ATSDGEKK 603
Query: 889 QEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRS--GGGPQGQEEASGVSPS 946
+EG RR S S + TL S + QEE G
Sbjct: 604 REGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKG---- 659
Query: 947 SLPRSSPEAVVREWLDNIPEEPILMTYELADETT-GAAGGGLRGPEVDPGDDHSLEGLGE 1005
S+ PE R+ ++ E ++ G++ GP+ GD + G+
Sbjct: 660 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK 719
Query: 1006 PAQAGQQSL-----EGDPGQ---DPEPEGALLGSSDTGPQSGEGV------PQGAAPEGV 1051
+ G + E DPGQ PE G+ P GEGV + P
Sbjct: 720 DKETGTDGILAGSQEHDPGQGSSSPEQAGS--------PTEGEGVSTWESFKRLVTPRKK 771
Query: 1052 SEAP-AEAGADREAPAGCRVSL-RALPGRVSASTQIMRALMGSKQGRPSSVPEV-----S 1104
S++ E D A +G S PG+ + I + + G ++ RP E +
Sbjct: 772 SKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDA 831
Query: 1105 RPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVG 1164
P S + L+ E + + + P + +SK+L
Sbjct: 832 GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL------S 885
Query: 1165 EDQLDSGLWELTWSQALPDLGSHAMT--ENFTPTSSSGVDISSGSGGSGESSVPCAMDGT 1222
E Q+ + A+ D G+ A T E +P+ S E+++
Sbjct: 886 ESQVH------MMAAAVAD-GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLE 938
Query: 1223 LVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDE------A 1276
E P + P++R E+ GD + P + A A +E A
Sbjct: 939 REVIAEEEPPTVTEPLPENR--EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 996
Query: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGV 1336
E +E A S L + +T +E ++E + G ++ +E +T+E LQ
Sbjct: 997 EETTEMVSAVSQLTD-SPDTTEEATPVQEVEGGVPD-------IEEQERRTQEVLQAVAE 1048
Query: 1337 QLEETKETEGEGQQEE--------EAQLEEIEETGGEGLQEE-----GVQLEEVKEGP-- 1381
+++E + G G E+ EA+ E E+ GL++E V +E K P
Sbjct: 1049 KVKEESQLPGTGGPEDVLQPVQRAEAERPE-EQAEASGLKKETDVVLKVDAQEAKTEPFT 1107
Query: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQEL---SEASSPDGKGSQE------------DDP 1426
+G + G+ E ++ E S+ EL +A + G SQE + P
Sbjct: 1108 QGKVVGQTTPESFEKAPQVTE-SIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP 1166
Query: 1427 VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLE---PGLEKPPG- 1482
E G S A GT + E E + ++ + G++ E E+PP
Sbjct: 1167 TDSETDG--STPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAP 1224
Query: 1483 ATMMGQEHTQAQ 1494
++ + QE T+ Q
Sbjct: 1225 SSFVFQEETKEQ 1236
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 122 bits (307), Expect = 3e-27
Identities = 255/1073 (23%), Positives = 405/1073 (37%), Gaps = 171/1073 (15%)
Query: 1312 GEGLQEEAVQLEET-KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEE 1370
GE +E+ + T K EE L+ E E + E GQ +EE +E G E ++E
Sbjct: 125 GEAASKESEPKQSTEKPEETLKREQSHAEISPPAES-GQA-----VEECKEEGEEKQEKE 178
Query: 1371 GVQLEEVKEGPEGGLQGEALEEGLKE--EGLPEEGSVHGQELSEASSPDGKGSQEDDPVQ 1428
+ E P G ++ + G ++ S + E + + K QE + V
Sbjct: 179 PSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVD 238
Query: 1429 EEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSA--------SERQSGSQLEPGLEKP 1480
EE G+A ++E A P EP E SA SE Q P EKP
Sbjct: 239 TEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKP 298
Query: 1481 -PGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
P AT + E + + AE + VS + ++TE+
Sbjct: 299 APLATEVFDEKIEVHQEEVVAE---------------VHVSTVEERTEE--------QKT 335
Query: 1540 ELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGR---------AGRMVLEP 1590
E+ G + L +M AE Q+ A+ ++ K + + G VL
Sbjct: 336 EVEETAGSVPAEELVEMDAEPQE--AEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSK 393
Query: 1591 PREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEE 1650
P E + E+ + + Q R +++G F+ + GL LS + G + G +
Sbjct: 394 PPEGVVSEVEMLSSQERMKVQGSPLKKLFT--STGLKKLSGKKQK--------GKRGGGD 443
Query: 1651 AEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGE-HTDGEAAEVA 1709
E E A SP S + G + E + L++ E DGEA E A
Sbjct: 444 EESGEHTQVPA-----DSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGA 498
Query: 1710 PGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDA-- 1767
+D R ++ V + + L++ K L E A
Sbjct: 499 T----SDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASE 554
Query: 1768 MAQEREGKTHNS---------ETSAGSE----LGEAEQEGEGISERGETGG--------- 1805
M +E +G +TS E +G +++ S E GG
Sbjct: 555 MQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQ 614
Query: 1806 ----QGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEA----E 1857
G E G A + DPGQ G +PE G + E EGV E+
Sbjct: 615 KADEAGKDKETGTDGILAGSQEHDPGQ-----GSSSPEQAG-SPTEGEGVSTWESFKRLV 668
Query: 1858 GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEW-----------EVQPESEGA 1906
++++ + + +SED A + P++E + E W + +P+ +
Sbjct: 669 TPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGK--EESWVSIKKFIPGRRKKRPDGKQE 726
Query: 1907 EAPEAE---KEAQPETESVEALETEGE-DEPESEGAEAQEAEEAAQEAEGQTQPE-SEVI 1961
+AP + A + V A+ E D E E EAQ+A+++A++ E + E S+ +
Sbjct: 727 QAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL 786
Query: 1962 ESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG-----EMQEAEEEA 2016
+ A ++ A + +E + + +E +E EAE E+ E E A
Sbjct: 787 SESQVHMMAAAVADGTRAATI-IEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIA 845
Query: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES-------------DGVEAPEAEEE 2063
+ E V +P E EA+ G+T +E + PE+ +G EA A EE
Sbjct: 846 EEEPPTV-TEPLPENREAR---GDTVVSEAELTPEAVTAAETAGPLGAEEGTEA-SAAEE 900
Query: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI-EAPETE 2122
E V + E QE EG P+ E E E AE + E +
Sbjct: 901 TTEMVSAVSQLTDSPDTTEEATPVQEVEG-GVPDIEEQERRTQEVLQAVAEKVKEESQLP 959
Query: 2123 GEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEE--AQPELEGV 2180
G PE + P EA+ E EA + E + ++AQEA+ E Q ++ G
Sbjct: 960 GTGGPED--VLQPVQRAEAERPEEQAEASGLKKETDVVLK-VDAQEAKTEPFTQGKVVGQ 1016
Query: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPE-LEGVEAPEAEEEAQPEPEGVETP---EAEGE 2236
PE+ +A +E IE+ E Q E L GV++ E E P+ VETP E +G
Sbjct: 1017 TTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGS 1076
Query: 2237 ---AQPESEGETQGEK----KGSPQVSLGDGQSEEASESSSPVPEDRPTPPPS 2282
A ++ G TQ ++ +V+ G QS + P ++RP P S
Sbjct: 1077 TPVADFDAPGTTQKDEIVEIHEENEVASGT-QSGGTEAEAVPAQKERPPAPSS 1128
Score = 100 bits (249), Expect = 2e-20
Identities = 151/694 (21%), Positives = 263/694 (37%), Gaps = 90/694 (12%)
Query: 1744 EDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE-----QEGEGIS 1798
++GEG+ KDP LG E + E + T E + E AE + G+ +
Sbjct: 106 DEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVE 165
Query: 1799 ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEA---------QPESE 1849
E E G + E + E+ P S+ + +G A +P+ +
Sbjct: 166 ECKEEGEEKQEKEPSKSAESPT----SPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKED 221
Query: 1850 GVEAPEAEGDAQ------EAEGEAQPESEDVEAPE-------AEGEAQP----ESEDVET 1892
VEA E + + + E +G+A+ SE + A E AE +P E E VE
Sbjct: 222 EVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVEL 281
Query: 1893 PEAEWEVQPESEGAEAPEAEKEAQPETESV-EALETEGEDEPE----SEGAEAQEAEEAA 1947
P E + G++ P EK A TE E +E E+ S E E ++
Sbjct: 282 PSEE-----QVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTE 336
Query: 1948 QEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE-AEGEAQPESEDVEAPEAE 2006
E + P E++E +EA+P E V+ E V ++ +G E V + E
Sbjct: 337 VEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPE 396
Query: 2007 GEMQEAEEEAQPESDGVEAQPKSE---GEEAQEVEGETQKTEGDAQPESDG--VEAPEAE 2061
G + E E + E V+ P + +++ G+ QK + E G + P
Sbjct: 397 GVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADS 456
Query: 2062 EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPET 2121
++QE + A PE E ++ E Q + E E ++GE +K EG+ +
Sbjct: 457 PDSQEEQKGESSASSPEEPE-EITCLEKGLAEVQQDGEAEEGATSDGE-KKREGVTPWAS 514
Query: 2122 EGEAQPESEGIEAPEAEGEAQPESEGVEA------QDAEGEAQPESEGIEAQEAEEEAQP 2175
+ + + P +E + + E + V++ + E Q E +G + EE +
Sbjct: 515 FKKMVTPKKRVRRP-SESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKR 573
Query: 2176 ELE---GVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPE 2232
+++ EA G ++ + + + EG P+ G + +A+E + + G +
Sbjct: 574 KVDTSVSWEALICVGSSKKRARRGSSSDEEG--GPKAMGGDHQKADEAGKDKETGTDGIL 631
Query: 2233 AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPE-------DRPTPPPSPGG 2285
A + +G + E+ GSP + G+G S S P + + G
Sbjct: 632 AGSQEHDPGQGSSSPEQAGSP--TEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGS 689
Query: 2286 DTPHQRPGSQTGPSSSRASSWGNC-----WQKDSENDHVLGDTRSPDAKSTGTPHAERKA 2340
H P ++ G + SW + ++ D DA TG +
Sbjct: 690 GVEHSTPDTEPG----KEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDV 745
Query: 2341 TRMYP-------ESSTSEQEEAPLGSRTPEQGAS 2367
+ P E E ++A + PEQ A+
Sbjct: 746 PAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAA 779
Score = 92.8 bits (229), Expect = 4e-18
Identities = 239/1137 (21%), Positives = 407/1137 (35%), Gaps = 144/1137 (12%)
Query: 1233 KTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLE-Q 1291
KTS ++P E+ + Q+ T + +A + +E+ ++ A S E +
Sbjct: 212 KTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR 271
Query: 1292 LAENTVQEEVQLEETKEGTEG------------------EGLQEEAV-QLEETKTEEGLQ 1332
L+ + E+ EE G++G E QEE V ++ + EE +
Sbjct: 272 LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTE 331
Query: 1333 EEGVQLEETK-ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
E+ ++EET E E +A+ +E E +E V+L+E E QG L
Sbjct: 332 EQKTEVEETAGSVPAEELVEMDAEPQEAEPA------KELVKLKETCVSGEDPTQGADLS 385
Query: 1392 EGLKEEGLPEEGSVHGQE-LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEP 1450
K P EG V E LS +GS + S + G +E
Sbjct: 386 PDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEE 445
Query: 1451 TEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSA 1510
+ + + P + E Q G E+P T + + + Q A E ++S
Sbjct: 446 SGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKK 505
Query: 1511 ALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQD 1570
P W S T K + + + E + D + + A +Q+
Sbjct: 506 REGVTP-WASFKKMVTPKKRVRRPSESDKE-------DELDKVKSATLSSTESTASEMQE 557
Query: 1571 STKRELQKLQGRAGRMVLEPPREALTG----ELLLQTQQRRHRLRGLRNLSAFSERTLGL 1626
K +++ + EP R+ T L+ ++ RG + + +G
Sbjct: 558 EMKGSVEEPKPE------EPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGG 611
Query: 1627 -----------------GPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSP 1669
G L+ + E +P ++ Q G EGE E+ ++ V+P
Sbjct: 612 DHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWES-FKRLVTP 670
Query: 1670 MSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGG 1729
++ ++E + G + + PGK + + + + G
Sbjct: 671 RKK------SKSKLEEKSE-----DSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKK 719
Query: 1730 LGPGLS-QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQER----------EGKTHN 1778
G Q P D G G + D + +E DA+ +E+ E
Sbjct: 720 RPDGKQEQAPVEDAGPTGANED--DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQK 777
Query: 1779 SETSAGSELGEAEQE------GEG------ISERGETGGQGSGHEDNLQGEAAAGGDQDP 1826
+ T EL E++ +G I ER + S E Q EA A +
Sbjct: 778 AATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEE 837
Query: 1827 GQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE--AQ 1884
E P E PE+ EA GD +E E PE+ V A E G A+
Sbjct: 838 VLEREVIAEEEPPTVTEPLPENR-----EARGDTVVSEAELTPEA--VTAAETAGPLGAE 890
Query: 1885 PESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
+E E V S+ ++P+ +EA P E + E E ++ AE
Sbjct: 891 EGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAE 950
Query: 1945 EAAQEAE--GQTQPESEVIESQEAEEEAQPESEDVEALEVE------VETQEAE------ 1990
+ +E++ G PE + Q AE E E + L+ E V+ QEA+
Sbjct: 951 KVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQ 1010
Query: 1991 ----GEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEG 2046
G+ PES + +AP+ ++ +E +++ + E Q + ++ +T
Sbjct: 1011 GKVVGQTTPESFE-KAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPT 1069
Query: 2047 DAQPESDGVEAPEAEEEAQEAEGEVQEAE-GEAHPESEDVDAQEA---EGEAQP-ESEGV 2101
D+ E+DG P A+ +A G Q+ E E H E+E ++ E EA P + E
Sbjct: 1070 DS--ETDG-STPVAD---FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERP 1123
Query: 2102 EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPES 2161
AP + ++ + E E + +E + + E + D + + P
Sbjct: 1124 PAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFF 1183
Query: 2162 EGIEAQ-EAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE----APE 2216
EG+E + E A + EG + E + +A E + A+ VE
Sbjct: 1184 EGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQV 1243
Query: 2217 AEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVP 2273
E+ + EP V + E E E + + V + DG E +S SP P
Sbjct: 1244 EREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPP 1300
Score = 76.6 bits (187), Expect = 3e-13
Identities = 184/887 (20%), Positives = 309/887 (34%), Gaps = 143/887 (16%)
Query: 1292 LAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEG-LQEEGVQLEETKETEGEGQQ 1350
L E ++ EV EE + T E L E +T E L E V ET G +
Sbjct: 834 LTEEVLEREVIAEE-EPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEG 892
Query: 1351 EEEAQLEEIEE--------TGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEE 1402
E + EE E T EE ++EV EGG+ +E +E L
Sbjct: 893 TEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEV----EGGVPDIEEQERRTQEVL--- 945
Query: 1403 GSVHGQELSEASSPDGKGSQED--DPVQEEEAGRASASAEPCPAEGTEEPTEP----PSH 1456
+++ E S G G ED PVQ EA R AE A G ++ T+ +
Sbjct: 946 -QAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAE---ASGLKKETDVVLKVDAQ 1001
Query: 1457 LSETDPSASERQSGSQLEPGLEKPPGATMMGQEH---TQAQPTQGAAERSSSVACSAALD 1513
++T+P + G EK P T + T Q A +S + A+
Sbjct: 1002 EAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIP 1061
Query: 1514 CDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLD------------QMAAELQ 1561
D + +T ++ VA+ A Q +++++ E +
Sbjct: 1062 PDSV-------ETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAE 1114
Query: 1562 QDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSE 1621
AQ+ + + + +E E E+ ++T + G + +++
Sbjct: 1115 AVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYAD 1174
Query: 1622 RTLGLGP----LSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMG 1677
P L +++ +S +++ + EG E C KK + ++
Sbjct: 1175 EKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAEC-----KKDDALELQSHAK 1229
Query: 1678 ATRGPIKEAFDLQQILQRKRGE--HTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLS 1735
+ P++ +Q ++ E H + E E T ++ S + +Q + G
Sbjct: 1230 SPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAK 1289
Query: 1736 QGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGE 1795
+ + EGS P LG+ E + + + +A +E + E
Sbjct: 1290 EVSSL------EGSP------PPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETA 1337
Query: 1796 GISERGETGGQGSGH--------EDNLQGEAAAGGDQDP--------------------G 1827
I E GET H E N A G D P G
Sbjct: 1338 NILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKG 1397
Query: 1828 QSDGAEGIEAPEAEGEAQPESE-----------GVEAPEAEGDAQEAEGEAQP------- 1869
S EG + + ++ E +E E E E E ++
Sbjct: 1398 LSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQ 1457
Query: 1870 -------ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESV 1922
+E+ E Q ++ ++ + + E EG E + ++ P T +
Sbjct: 1458 TAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAK 1517
Query: 1923 EALETEGEDEPESE-GAEAQEAEEAAQ--EAEGQT----QPESEVIESQE----AEEEAQ 1971
E E+ + S+ + EA E E EG T Q E V+ S+E A ++
Sbjct: 1518 EESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSV 1577
Query: 1972 PESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEM---QEAEEEAQPESDGVEAQPK 2028
PE + L +E E + + +DV+ PE + +A ES +
Sbjct: 1578 PEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQ 1637
Query: 2029 SEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAE 2075
E E+AQEVE + EG ESD P+A+EE Q+ E E ++E
Sbjct: 1638 KEKEDAQEVELQ----EGKVHSESDKAITPQAQEELQKQERESAKSE 1680
Score = 76.3 bits (186), Expect = 3e-13
Identities = 127/558 (22%), Positives = 208/558 (37%), Gaps = 92/558 (16%)
Query: 1900 QPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESE 1959
Q +SE +++KE ++ V + +G++E + +E +E T+ ++
Sbjct: 11 QRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQAN 70
Query: 1960 VIESQE----------AEEEAQPESEDVEALEVEVETQE------------------AEG 1991
I ++ +++ + + V+ L V+ + E A
Sbjct: 71 DIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASK 130
Query: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA--QPKSEGEEAQEVE----------- 2038
E++P+ + E PE + +++ E P ++ +A + K EGEE QE E
Sbjct: 131 ESEPK-QSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSP 189
Query: 2039 -----GETQK---TEGDA---------QPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPE 2081
G T K T+G A +P+ D VEA E ++E QE E E +G+A
Sbjct: 190 VTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKE-QEPEKVDTEEDGKAEVA 248
Query: 2082 SEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-----GIEAPE 2136
SE + A E + Q +E P E +K E + G P E E +
Sbjct: 249 SEKLTASE-QAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFD 307
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGI 2196
+ E E E + E + E + E +E P E VE EA+P E +
Sbjct: 308 EKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSV-PAEELVEMDAEPQEAEPAKELV 366
Query: 2197 EAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV--ETPEAEGEAQPESEGE-------TQG 2247
+ E + +G + E+ PEGV E + + + +G + G
Sbjct: 367 KLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTG 426
Query: 2248 EKKGSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSW 2306
KK S + G G +E S + VP D P G++ P P
Sbjct: 427 LKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEE---PEEITCLEK 483
Query: 2307 GNC-WQKDSENDHVLGDTRSPDAKSTG-TPHAE-------RKATRMYPESSTSEQEEAPL 2357
G Q+D E + G T + K G TP A +K R P S E E +
Sbjct: 484 GLAEVQQDGEAEE--GATSDGEKKREGVTPWASFKKMVTPKKRVRR-PSESDKEDELDKV 540
Query: 2358 GSRTPEQGASEGYDLQED 2375
S T S ++QE+
Sbjct: 541 KSATLSSTESTASEMQEE 558
Score = 69.7 bits (169), Expect = 3e-11
Identities = 253/1209 (20%), Positives = 433/1209 (35%), Gaps = 199/1209 (16%)
Query: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQL---EETKEGTEGEGLQEEAVQLEETK 1326
A+ E + S E+ ++ + +V E + K G EE K
Sbjct: 552 ASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEG----GPK 607
Query: 1327 TEEGLQEEGVQLEETKETEGEG-----QQEEEAQLEEIEETGGEGLQEEGVQLEE----- 1376
G ++ + + KET +G Q+ + Q E G + EGV E
Sbjct: 608 AMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRL 667
Query: 1377 ----------VKEGPEGGLQGEALEEGLKE-EGLPEEGSVHGQEL---SEASSPDGKGSQ 1422
++E E + G +E + E EE V ++ PDGK Q
Sbjct: 668 VTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGK--Q 725
Query: 1423 EDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPP- 1481
E PV E+AG A+ + ++ P P LSE D E+ Q + E+P
Sbjct: 726 EQAPV--EDAGPTGANEDD-----SDVPAVVP--LSEYDAVEREKMEAQQAQKSAEQPEQ 776
Query: 1482 -GATMMGQEHTQAQP-TQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVA 1539
AT + +E +++Q AA + A + + P W+S A + +
Sbjct: 777 KAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWIS-----------ASVTEPLE 825
Query: 1540 ELRARWGLQDNDLLDQ--MAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTG 1597
++ A L ++L++ +A E V + L ++ + + A E EA+T
Sbjct: 826 QVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEA-----ELTPEAVTA 880
Query: 1598 ELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEG---- 1653
+T G SA E T + +S L D P T + +E EG
Sbjct: 881 A---ETAGPLGAEEGTE-ASAAEETTEMVSAVS-QLTDSP--DTTEEATPVQEVEGGVPD 933
Query: 1654 --EEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPG 1711
E+ + ++ + ++ + T GP D+ Q +QR E + E AE +
Sbjct: 934 IEEQERRTQEVLQAVAEKVKEESQLPGTGGPE----DVLQPVQRAEAERPE-EQAEASGL 988
Query: 1712 KTHTDPTSTRTVQGAE----------GGLGP-GLSQGPGVDEGEDGEGSQRLNRDKDPKL 1760
K TD Q A+ G P + P V E E S+ + + L
Sbjct: 989 KKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESI--ESSELVTTCQAETL 1046
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGE----AEQEGEGISERGETGGQGSGHEDNLQG 1816
+ M E+ + ET SE A+ + G +++ E HE+N
Sbjct: 1047 AGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIV---EIHEEN--- 1100
Query: 1817 EAAAGGDQDPGQSDGAEGIEAPEAEGEAQP-------ESEGVEAPEAEGDAQEAEGEAQP 1869
E A+G QS G E EA A+ E P + E E + E + + E
Sbjct: 1101 EVASGT-----QSGGTEA-EAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSV 1154
Query: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAP-EAEKEAQPETESVEALETE 1928
E+ + + + + D +T + P EG E + E + AL+ E
Sbjct: 1155 ETVSILSKTEGTQEADQYADEKTKDV-----PFFEGLEGSIDTGITVSREKVTEVALKGE 1209
Query: 1929 GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQE 1988
G +E E + +A E + A+ + E V++ + + EA+P + E LE E
Sbjct: 1210 GTEEAECKKDDALELQSHAKSPPSPVEREM-VVQVEREKTEAEPTHVNEEKLEHETAVTV 1268
Query: 1989 AEGEAQPESEDVEAPEAEGEMQEAEEEAQP--------------ESDGVEA--------- 2025
+E ++ + V P +G + + E P + EA
Sbjct: 1269 SEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAE 1328
Query: 2026 QPKSEGEEAQEVE-GETQKTEGD----------------AQPESDGVEA-PEAEEE---- 2063
+ K GE A +E GET + G A P D V P+ + +
Sbjct: 1329 EEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPV 1388
Query: 2064 ---AQEAEGEVQEAEGEAHP----ESEDVDAQEAEGEAQPESEGVEAPEAEG-------- 2108
A +G + EGE +S++VD Q A E + S +E E E
Sbjct: 1389 IVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKV-SVAIEDLEPENGILELETK 1447
Query: 2109 EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE 2168
++ + I + + E E +E + Q ++QDA E E EG E Q
Sbjct: 1448 SSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQET--EKEGEEPQA 1505
Query: 2169 AEEEAQPELEGVEAPE--AEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE 2226
+ ++ P E E A G+A + + +E E+EG + + E P
Sbjct: 1506 SAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPS 1565
Query: 2227 GVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGD 2286
E A ++ PE +G ++ + + + E+ + P ++ G
Sbjct: 1566 EEEGGGAGTKSVPEDDGHALLAERIEKSL-VEPKEDEKGDDVDDPENQNSALADTDASGG 1624
Query: 2287 TPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPE 2346
+ P + GP ++D++ + ++ TP A+ + + E
Sbjct: 1625 LTKESPDT-NGPKQKE--------KEDAQEVELQEGKVHSESDKAITPQAQEELQKQERE 1675
Query: 2347 SSTSEQEEA 2355
S+ SE E+
Sbjct: 1676 SAKSELTES 1684
Score = 48.9 bits (115), Expect = 6e-05
Identities = 222/1092 (20%), Positives = 374/1092 (34%), Gaps = 151/1092 (13%)
Query: 492 ERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGR 551
E AG +DP L GAG ++ + EE + S + S S G
Sbjct: 109 EGAAGAGDHKDPSL---GAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAES--GQA 163
Query: 552 PQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAETQG-QGTEQATGAAVTREP 610
+ C + + ++ + P SP S + S + TQG G + T +E
Sbjct: 164 VEECKEEGEEKQEKEPSKSAESPTSPVTSETG--STFKKFFTQGWAGWRKKTSFRKPKED 221
Query: 611 LVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSR---ASAMSSPSSPGLGRVAPRGHPRH 667
V + E P + + G+ S AS + P P PR +
Sbjct: 222 EVEASEKKKEQE-----PEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEY 276
Query: 668 SHYRKDTHSPLDSSV--TKQVPRP------PERRRACQDGSVPRYSGSSSSTRTQASGNL 719
+ + S +++ P P E+ Q+ V S+ RT+
Sbjct: 277 EKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTE 336
Query: 720 RPPSSGSLPSQDL--LGTSSATVTPA-----VHSDFVSGVSPHNAPSAGWAGDAGSRTCS 772
++GS+P+++L + PA + VSG P A + D +
Sbjct: 337 VEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDP--TQGADLSPDEKVLSKP 394
Query: 773 PAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVG----PHRSHCCSQ 828
P + S+ G + S+ L G+ ++G G H
Sbjct: 395 PEGVVSEVEMLSSQERMKVQGSPLKKL-FTSTGLKKLSGKKQKGKRGGGDEESGEHTQVP 453
Query: 829 PGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSP 888
+ +QE Q+G S +S P P C ++ + G + + A G
Sbjct: 454 ADSPDSQEEQKGESSASS-------PEEPEEITCLEKGLAEVQQDGEAEEG-ATSDGEKK 505
Query: 889 QEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRS--GGGPQGQEEASGVSPS 946
+EG RR S S + TL S + QEE G
Sbjct: 506 REGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKG---- 561
Query: 947 SLPRSSPEAVVREWLDNIPEEPILMTYELADETT-GAAGGGLRGPEVDPGDDHSLEGLGE 1005
S+ PE R+ ++ E ++ G++ GP+ GD + G+
Sbjct: 562 SVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGK 621
Query: 1006 PAQAGQQSL-----EGDPGQ---DPEPEGALLGSSDTGPQSGEGV------PQGAAPEGV 1051
+ G + E DPGQ PE G+ P GEGV + P
Sbjct: 622 DKETGTDGILAGSQEHDPGQGSSSPEQAGS--------PTEGEGVSTWESFKRLVTPRKK 673
Query: 1052 SEAP-AEAGADREAPAGCRVSL-RALPGRVSASTQIMRALMGSKQGRPSSVPEV-----S 1104
S++ E D A +G S PG+ + I + + G ++ RP E +
Sbjct: 674 SKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDA 733
Query: 1105 RPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVG 1164
P S + L+ E + + + P + +SK+L
Sbjct: 734 GPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKEL------S 787
Query: 1165 EDQLDSGLWELTWSQALPDLGSHAMT--ENFTPTSSSGVDISSGSGGSGESSVPCAMDGT 1222
E Q+ + A+ D G+ A T E +P+ S E+++
Sbjct: 788 ESQVH------MMAAAVAD-GTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLE 840
Query: 1223 LVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDE------A 1276
E P + P++R E+ GD + P + A A +E A
Sbjct: 841 REVIAEEEPPTVTEPLPENR--EARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAA 898
Query: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGV 1336
E +E A S L + +T +E ++E + G ++ +E +T+E LQ
Sbjct: 899 EETTEMVSAVSQLTD-SPDTTEEATPVQEVEGGVPD-------IEEQERRTQEVLQAVAE 950
Query: 1337 QLEETKETEGEGQQEE--------EAQLEEIEETGGEGLQEE-----GVQLEEVKEGP-- 1381
+++E + G G E+ EA+ E E+ GL++E V +E K P
Sbjct: 951 KVKEESQLPGTGGPEDVLQPVQRAEAERPE-EQAEASGLKKETDVVLKVDAQEAKTEPFT 1009
Query: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQEL---SEASSPDGKGSQE------------DDP 1426
+G + G+ E ++ E S+ EL +A + G SQE + P
Sbjct: 1010 QGKVVGQTTPESFEKAPQVTE-SIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETP 1068
Query: 1427 VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLE---PGLEKPPG- 1482
E G S A GT + E E + ++ + G++ E E+PP
Sbjct: 1069 TDSETDG--STPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAP 1126
Query: 1483 ATMMGQEHTQAQ 1494
++ + QE T+ Q
Sbjct: 1127 SSFVFQEETKEQ 1138
>gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
Length = 673
Score = 119 bits (298), Expect = 4e-26
Identities = 161/584 (27%), Positives = 227/584 (38%), Gaps = 64/584 (10%)
Query: 1690 QQILQRKRGEHTD-GEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEG 1748
Q I++ TD + A + G T P S + G PG Q PG
Sbjct: 125 QSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEAN 184
Query: 1749 SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS 1808
+ P+ G ++ ++ R G+ + G + EG +E TG G
Sbjct: 185 GPCPSPIPTPEQGLSQRAVPSEGRVGE------AKGGGVVSVVWEGLRATEDCATGATGP 238
Query: 1809 GHEDNLQGEAAAGGDQDPGQSDGAEGIEAP----EAEGEAQPESEGVEAPEAEGDAQEAE 1864
E ++ + G GA +E P E G + EGV +AE A
Sbjct: 239 ELEAKVEEVVL----EAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAE-----AM 289
Query: 1865 GEAQ--PESEDVEAPEA----EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPE 1918
GE PE +P E A E EDV E + Q S G E E
Sbjct: 290 GEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTL 349
Query: 1919 TESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVE 1978
+E E L EG + PE G E +E+ AEG E E+ EAE+ ES
Sbjct: 350 SEEWEELLVEGLEGPEVAGRE--RGDESPLGAEGAKTGGGE--ETWEAEKRKAEES---- 401
Query: 1979 ALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVE 2038
+ + ++E G + E+E E +G E++ + ES G + +E E +E
Sbjct: 402 ---MGIGSEEKPGTGRDEAEMSPVVERKG----GEKKLELESRGSAEKLGTEREGGEEPL 454
Query: 2039 GETQKTEGDAQPESDGVEAPE-AEEEAQEAEGEVQEAEGEAHPES--EDVDAQEAEGEAQ 2095
G +K EG + E +G E AEEE E V++ GE PE+ E ++A+ GE
Sbjct: 455 GIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEET 514
Query: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEG 2155
E+E E E +K +G TEG+ E E E++ E +E +A
Sbjct: 515 LEAEK-RGGEESLETEKTQG-----TEGDLNLEQGSREGSESQAEEM--NEAGPPLEANT 566
Query: 2156 EAQPESEGIEAQEA-----EEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELE 2210
E +PE EG + QE EEE E G+A P APE E QP L+
Sbjct: 567 ETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQ 626
Query: 2211 GVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
G E P A A P P QPE T+GE+ P+
Sbjct: 627 G-EGPSANPSAHPVPTYAPA------RQPEPSAPTEGEEASGPK 663
Score = 97.8 bits (242), Expect = 1e-19
Identities = 156/600 (26%), Positives = 220/600 (36%), Gaps = 74/600 (12%)
Query: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQ 1815
KDP+ E + A + E ++ +L ++ G G + GH Q
Sbjct: 68 KDPQSPEGQAQARIRNLEDSLFTLQSQL--QLLQSASTGAQHKPSGRPSWRRQGHRPLSQ 125
Query: 1816 GEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGV-------------EAPEAEGDAQE 1862
AG GQ+D + P PES + P A GD+ E
Sbjct: 126 SIVEAGS---VGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSE 182
Query: 1863 AEGEAQPESEDVEAPEA--EGEAQPESEDVETPEAEWEVQPESEGAEAPE--AEKEAQPE 1918
A G P + PE A P V + V EG A E A PE
Sbjct: 183 ANG---PCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPE 239
Query: 1919 TESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQ----PES 1974
E+ + E E + +GA + E +E G + E + +AE + PE
Sbjct: 240 LEA-KVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEV 298
Query: 1975 EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEA 2034
+ ++ + E A E EDV EG+ Q + VE SE E
Sbjct: 299 VQTSSPRLQ---ERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEE 355
Query: 2035 QEVEGETQKTEG-DAQPESDGVEAPEAEEEAQEAEGE-VQEAEGEAHPESEDVDAQEAEG 2092
VEG EG + G E+P E A+ GE EAE ES + ++E G
Sbjct: 356 LLVEG----LEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPG 411
Query: 2093 EAQPESEGVEAPEAEGEAQKAE-----GIEAPETEGEAQPESEGIEAPEAEGEAQPESEG 2147
+ E+E E +G +K E E TE E E GIE + EG + E EG
Sbjct: 412 TGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIER-KVEGHLRAEKEG 470
Query: 2148 -VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQ 2206
E + AE E E G+E + EEE + E +EA GE E +EA + GE
Sbjct: 471 DEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGE-----ETLEAEKRGGEES 525
Query: 2207 PELEGVEAPE------------AEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK---- 2250
E E + E +E +A+ E EA E +PE EG EK
Sbjct: 526 LETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGAL 585
Query: 2251 ----GSPQVSL-GDGQSEEASE--SSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRA 2303
PQ + G G +A+ + +P PE P G+ P P + P+ + A
Sbjct: 586 EEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPA 645
Score = 82.0 bits (201), Expect = 6e-15
Identities = 115/432 (26%), Positives = 160/432 (37%), Gaps = 78/432 (18%)
Query: 1703 GEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGE 1762
GE V + P ++ A G + QG +G+ G G +
Sbjct: 290 GEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGE------------ 337
Query: 1763 AEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAA--A 1820
EG + ER + E E EG E E G+ G E L E A
Sbjct: 338 -EGSFIWVER--------VTLSEEWEELLVEG---LEGPEVAGRERGDESPLGAEGAKTG 385
Query: 1821 GGDQ----DPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDV-- 1874
GG++ + +++ + GI + E G + E+E E +G ++ E E++ +E +
Sbjct: 386 GGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGT 445
Query: 1875 -----EAP-----EAEGEAQPESE-DVETPEAEWEVQPESEGAEAPEAEKEAQPETESVE 1923
E P + EG + E E D E AE E E G E E+E + E +E
Sbjct: 446 EREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLE 505
Query: 1924 ALETEGED--EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALE 1981
A GE+ E E G E E Q EG E E E++ E E+ LE
Sbjct: 506 AERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGP--PLE 563
Query: 1982 VEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGET 2041
ET+ + QP+ + V A E E GV+ Q +EG
Sbjct: 564 ANTETRPEKEGPQPQEKPVGALEEE---------------GVKPQTAAEG---------- 598
Query: 2042 QKTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
Q GDA P APE E Q +GE A AHP A++ E A E E
Sbjct: 599 QGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGE- 657
Query: 2101 VEAPEAEGEAQK 2112
EA G QK
Sbjct: 658 ----EASGPKQK 665
Score = 62.8 bits (151), Expect = 4e-09
Identities = 129/576 (22%), Positives = 216/576 (37%), Gaps = 110/576 (19%)
Query: 1857 EGDAQEAEGEAQPESEDVEAPEAEGEAQPES--EDVETPEAEWEV-QPESEGAEAPEAEK 1913
+G A E P S+D ++PE + +A+ + + + T +++ ++ Q S GA+ + +
Sbjct: 53 DGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGR 112
Query: 1914 EA------QPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIE----S 1963
+ +P ++S+ + G+ + + A E ++P +V+
Sbjct: 113 PSWRRQGHRPLSQSIVEAGSVGQTDLNKRAS--LPAGLVGTPPESPSEPREDVLGFLPGP 170
Query: 1964 QEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEG--------EMQEAEEE 2015
++ A SE + T E + + EA+G E A E+
Sbjct: 171 RQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATED 230
Query: 2016 AQPESDGVEAQPKSE-----------GEEAQEVEGETQKTEGDAQPESDGVEAPEAE--- 2061
+ G E + K E G + E+ ++ G + +GV +AE
Sbjct: 231 CATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMG 290
Query: 2062 ------EEAQEAEGEVQEA-EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
E Q + +QE E A E EDV EG+ Q S G EG E
Sbjct: 291 EIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGG-----EEGSFIWVE 345
Query: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ E E E G+E PE G + + + A+ A+ G E EAE+
Sbjct: 346 RVTLSEEWEELLVE--GLEGPEVAGRERGDESPLGAEGAK-----TGGGEETWEAEKRKA 398
Query: 2175 PELEGVEAPEAEGEAQPESEGIEAPEAEG-EAQPELEGVEAPE---AEEEAQPEPEGVET 2230
E G+ + E G + E+E E +G E + ELE + E E E EP G+E
Sbjct: 399 EESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIER 458
Query: 2231 PEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQ 2290
+ EG + E EG+ EK+G+ + EE E P GG+ +
Sbjct: 459 -KVEGHLRAEKEGDE--EKRGA--------EEEEVEE---------PLGVEKKGGE---E 495
Query: 2291 RPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS 2350
P + P + +K E T AE++ ES +
Sbjct: 496 EPEATKEPLEAE--------RKGGEE----------------TLEAEKRGGE---ESLET 528
Query: 2351 EQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEA 2386
E+ + G EQG+ EG + Q ++ + P EA
Sbjct: 529 EKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEA 564
Score = 58.9 bits (141), Expect = 6e-08
Identities = 60/208 (28%), Positives = 96/208 (46%), Gaps = 25/208 (12%)
Query: 1276 AERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEET-KTEEGLQEE 1334
AE++ +E++ + E++ E E+ EE E T+ E L+ E EET + E+ EE
Sbjct: 466 AEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATK-EPLEAERKGGEETLEAEKRGGEE 524
Query: 1335 GVQLEETKETEGEGQQEE------EAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
++ E+T+ TEG+ E+ E+Q EE+ E G E + KEGP+ E
Sbjct: 525 SLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPP--LEANTETRPEKEGPQ---PQE 579
Query: 1389 ALEEGLKEEGLPEEGSVHGQ-ELSEAS-----SPDGKGSQEDDPVQEEEAGRASASAEPC 1442
L+EEG+ + + GQ L +A+ +P + E P+ + E A+ SA P
Sbjct: 580 KPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPV 639
Query: 1443 PAEGTEEPTEPPSHLSETDPSASERQSG 1470
P EP + P+ E SG
Sbjct: 640 PTYAPARQPEPSA------PTEGEEASG 661
Score = 44.3 bits (103), Expect = 0.001
Identities = 59/209 (28%), Positives = 84/209 (40%), Gaps = 29/209 (13%)
Query: 1299 EEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKET-EGEGQQEEEAQLE 1357
E V L E E EGL+ V E E L EG + +ET E E ++ EE+
Sbjct: 345 ERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGI 404
Query: 1358 EIEETGGEGLQEEGVQLEEVKEGPEGGLQ----GEALEEGLKEEGLPE----EGSVHGQE 1409
EE G G E + ++G E L+ G A + G + EG E E V G
Sbjct: 405 GSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHL 464
Query: 1410 LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQS 1469
+E + K E++ V EE G E P E T+EP E +ER+
Sbjct: 465 RAEKEGDEEKRGAEEEEV-EEPLGVEKKGGEEEP-EATKEPLE------------AERKG 510
Query: 1470 GSQLEPGLEKPPGATMMGQEHTQAQPTQG 1498
G + ++ G+E + + TQG
Sbjct: 511 GEETLEAEKRG------GEESLETEKTQG 533
Score = 33.5 bits (75), Expect = 2.6
Identities = 66/321 (20%), Positives = 103/321 (32%), Gaps = 28/321 (8%)
Query: 809 QVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSS 868
+V E+G P + G + EA++ + E+ + P R S
Sbjct: 365 EVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEA---EMSP 421
Query: 869 SCGSTGSSHQSTARGPGGSPQEGT-RQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKT 927
G + G + + GT R+ G P + +G + +EE+
Sbjct: 422 VVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEE 481
Query: 928 LRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGL 987
+ P G E+ G + EA + + + E L E T G L
Sbjct: 482 VEE---PLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDL 538
Query: 988 RGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAA 1047
++ G E E LE + PE EG G EGV A
Sbjct: 539 N---LEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTA 595
Query: 1048 PEG----------VSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRP 1097
EG ++E PA E PA C+ L+ + S + ++Q P
Sbjct: 596 AEGQGPLGDATPLLAETPAP-----EQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEP 650
Query: 1098 SSV---PEVSRPMARRLSCSA 1115
S+ E S P + C A
Sbjct: 651 SAPTEGEEASGPKQKTCQCCA 671
Score = 33.1 bits (74), Expect = 3.4
Identities = 27/125 (21%), Positives = 39/125 (31%), Gaps = 6/125 (4%)
Query: 479 GVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPE------QGGRLTPRARSEEGAS 532
G + +G E+K G E ++ GG E +GG + +G
Sbjct: 476 GAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTE 535
Query: 533 SDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSLSSLRSDDLQAE 592
D + GS EGS A T + EG P + Q
Sbjct: 536 GDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTA 595
Query: 593 TQGQG 597
+GQG
Sbjct: 596 AEGQG 600
>gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
Length = 1530
Score = 116 bits (291), Expect = 2e-25
Identities = 266/1184 (22%), Positives = 460/1184 (38%), Gaps = 198/1184 (16%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E E+ E ++A + + E + + +++E K + +E KT GL+
Sbjct: 415 EKSTEKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAK------FSAQEIKT--GLK 466
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
E +EE GQ+ LE+ +E + EE +++E K+G + +G+A
Sbjct: 467 EVVTAVEEMTSKGKPGQEV----LEDDQENTLKYEYEEDFEVDEEKQGEKSNEEGQA--- 519
Query: 1393 GLKEEGLPE------EGSVHGQELSEASS---PDGKGS--QEDDPVQEEE---------- 1431
++ G+P+ + ++ ++ SE SS PD + + E+D E E
Sbjct: 520 DVQMNGIPQSPLDDKKDNLDPEKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKT 579
Query: 1432 AGRASASAEPCPAEGTEEPT--EPPSHL-SETDPSASERQSGSQLEPGLEKPPGATMMGQ 1488
A S+ + P ++ +E + +H S TD SA R+S SQ +KP + + +
Sbjct: 580 ASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESA--RRSSSQELSENDKPRKSHLPIE 637
Query: 1489 EHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQ 1548
E + + E + + + + D + +VL + TEK +AE GL
Sbjct: 638 ESLEIEIED--QEITKADVETKPMPIDESFENVLKEGTEKG-----TQEIAE-----GLS 685
Query: 1549 DNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRH 1608
+ A E ++D ++ ++ST + K G G + E +++L +L
Sbjct: 686 EKSGKHVSAEEKEKDKSKLWEESTAQVKDKKAGLPG--LEEGGKDSLPLAYVL------- 736
Query: 1609 RLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVS 1668
LG ++F +++ A+++ SQ + +K
Sbjct: 737 --------------ALGAPTMNFMVDETAAINSNKESQQ---------------LVQKTY 767
Query: 1669 PMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEG 1728
+ K M P D I+Q K GEA G H P +
Sbjct: 768 TLEKKEAMEEDEAPQHRDAD---IVQGKGEAALWGEA-----GAVHEAPLRAWKPTAEQP 819
Query: 1729 GLGPGLSQ----GPGVDEGEDG----EGSQRLNRDKDPKLGEAEG-DAMAQER-EGKTHN 1778
L ++ PG++ G +G EG +RL +G+A DA+ + E
Sbjct: 820 ELAEEFTEKREIPPGIERGAEGAAEAEGVRRLGEGGSDPIGQAAAKDAVGLSKDEAPEKQ 879
Query: 1779 SETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAP 1838
+ E +A EGE E+ + + E AA + + AEG A
Sbjct: 880 ALMLTVLETDKAASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAV 939
Query: 1839 EAEGEAQPES----------EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESE 1888
GE++ E+ E + +G + G +P E E E P
Sbjct: 940 SDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSP--- 996
Query: 1889 DVETPEAEWEVQPESEGA-EAPEAEKEAQPETESVEALE--TEGEDEPESEGAEAQEAE- 1944
T EAE SEG+ E KEA E VE E TE E E + E E
Sbjct: 997 --FTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKEL 1054
Query: 1945 EAAQEAEGQTQPESEVIESQEAEEEAQPES--EDVEALEVEVETQEAEGEAQPE---SED 1999
+ A+E +P++ + ++ EE + +D +A + E + + EGE + E E+
Sbjct: 1055 DLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEE 1114
Query: 2000 VEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPE 2059
+AP E +AE EA E+ + P GE++ + ET +A P
Sbjct: 1115 TKAPPNE-MGSDAENEAPVEASELSDNPGLLGEDSLK---ETVVPIFEA--------TPG 1162
Query: 2060 AEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG-IEA 2118
E+ + +E GE E+ D + ++ E + E+ ++ EG Q EG + A
Sbjct: 1163 FEKSLENITALRKEGGGERLSEARDTEHKDREELSSRENRALK----EGHRQDGEGALAA 1218
Query: 2119 PETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELE 2178
PE E + ++APE A ++E + A+D + A G+E + AE +
Sbjct: 1219 PEAEPAGK-----VQAPEGLIPATGQAEELAAKDHDSCA-----GLEGR-AEGQG----- 1262
Query: 2179 GVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEE--EAQPEPEGVETPEAEGE 2236
GV+ EA E + I A + EA E PE EE E E E ++ +EG+
Sbjct: 1263 GVDVVLRTQEAVAEEDPIMAEKFREEAVD-----EDPEEEEDKECTLETEAMQDRNSEGD 1317
Query: 2237 AQPESEGETQ------GEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQ 2290
E EG TQ G + + +V G G++ E + V G +T +
Sbjct: 1318 GDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAAEEREV---------LAGSETAEE 1368
Query: 2291 RPGSQTGPSSSRASSWGNCWQKDS--ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESS 2348
+ +++ASS+ + ++++ + D ++G T + + E +
Sbjct: 1369 K------TIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEEVPAAEEMT 1422
Query: 2349 TSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADG 2392
+ EA +G TP + L ++Q GS A G DG
Sbjct: 1423 VTYTTEAGVG--TPGALERKTSGLGQEQEEGSEGQEAATGSGDG 1464
Score = 75.9 bits (185), Expect = 5e-13
Identities = 211/963 (21%), Positives = 363/963 (37%), Gaps = 167/963 (17%)
Query: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGEGLQEEAVQLEET--- 1325
++ ++ A R S ++ + ++ + + ++E +++E E +E T+ + ++ + + ++E+
Sbjct: 609 SSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKAD-VETKPMPIDESFEN 667
Query: 1326 ----KTEEGLQE--EGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE 1379
TE+G QE EG+ + K E +++++++L E E Q+++ K
Sbjct: 668 VLKEGTEKGTQEIAEGLSEKSGKHVSAEEKEKDKSKLWE----------ESTAQVKDKKA 717
Query: 1380 GPEGGLQGEALEEGLKEE---------GLP-------EEGSVHGQELSEASSPDGKGSQE 1423
G G LEEG K+ G P E +++ + S+ ++
Sbjct: 718 GLPG------LEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNKESQQLVQKTYTLEK 771
Query: 1424 DDPVQEEEA----------GRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQL 1473
+ ++E+EA G+ A+ E P +E A E ++
Sbjct: 772 KEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTAEQPELAEEFTEKREI 831
Query: 1474 EPGLEK-------PPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLL--- 1523
PG+E+ G +G+ + Q AA+ + ++ A + + ++VL
Sbjct: 832 PPGIERGAEGAAEAEGVRRLGEGGSDPIG-QAAAKDAVGLSKDEAPEKQALMLTVLETDK 890
Query: 1524 ------KKTEKAFLAHLASA--------VAELRARWGLQDNDLLDQMAA----ELQQDVA 1565
+ EKA LA+ A+A VA LR ++ + +A E +++ +
Sbjct: 891 AASEGEQGLEKAVLANEAAALNLEHLHEVAALREAATSEEGEAEGGVAVSDVGESEEEAS 950
Query: 1566 QRLQDSTKRE--LQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAF--SE 1621
L+D+ E K + + +L A + +++T+ R G S SE
Sbjct: 951 IDLEDTGPMEDTASKREDGSEEAILGGEEPAKERKEVMRTETRLSPFTGEAEASRMQVSE 1010
Query: 1622 RTLGLGPLS----FTLEDEPALSTALGSQLGEEAEGEEFCPCEA-CVRKKVSPMSPKATM 1676
+ G L+ ED ++ E + +E P E R++ PK ++
Sbjct: 1011 GSPEEGSLAKEAFLCKEDVEGEEMVTEAEANREDDRKEILPKELDLARERRKAERPKTSL 1070
Query: 1677 GATRGPIKE-----------AFDLQQILQRKRGE-HTDGEAAE---VAPGKTHTDPTSTR 1721
T +E AF +Q L+ + GE T+ A E P + +D +
Sbjct: 1071 RKTDSEREEVTRANALKDEDAFKEEQKLKAEEGETETEVRAEEETKAPPNEMGSDAENEA 1130
Query: 1722 TVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSET 1781
V+ +E LS PG+ GED L P G + E T +
Sbjct: 1131 PVEASE------LSDNPGL-LGEDS-----LKETVVPIFEATPG--FEKSLENITALRKE 1176
Query: 1782 SAGSELGEAE----QEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-- 1835
G L EA ++ E +S R E GH + +G AA + G+ EG+
Sbjct: 1177 GGGERLSEARDTEHKDREELSSR-ENRALKEGHRQDGEGALAAPEAEPAGKVQAPEGLIP 1235
Query: 1836 ---EAPEAEGEAQPESEGVEAPEAEGDA--------QEAEGEAQPESEDVEAPEAEGEAQ 1884
+A E + G+E AEG QEA E P + EA E
Sbjct: 1236 ATGQAEELAAKDHDSCAGLEG-RAEGQGGVDVVLRTQEAVAEEDPIMAEKFREEAVDEDP 1294
Query: 1885 PESEDVE-TPEAEWEVQPESEGAEAPEAEKEAQPETES----VEALET-EGEDEPESEGA 1938
E ED E T E E SEG E E Q V A+E G E A
Sbjct: 1295 EEEEDKECTLETEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGETAETAA 1354
Query: 1939 EAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV-----EALEVEVETQEAEGEA 1993
E +E ++ AE +T S AEEE + +++ A +V VE GE
Sbjct: 1355 EEREVLAGSETAEEKTIANKASSFSDVAEEETWHQQDELVGKTAAAGKVVVEELARSGEE 1414
Query: 1994 QPESED--VEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
P +E+ V G E + G E + SEG+EA G+ ++ G A+
Sbjct: 1415 VPAAEEMTVTYTTEAGVGTPGALERKTSGLGQEQEEGSEGQEAATGSGDGRQETGAAEKF 1474
Query: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQ 2111
G+ +E E E PES A E+ + +GE++
Sbjct: 1475 RLGLS---------------REGERELSPESLQAMATLPVKPDFTETREKQQHMVQGESE 1519
Query: 2112 KAE 2114
A+
Sbjct: 1520 TAD 1522
Score = 73.6 bits (179), Expect = 2e-12
Identities = 154/704 (21%), Positives = 253/704 (35%), Gaps = 138/704 (19%)
Query: 1755 DKDPKLGEAEGDAMAQE----------REGKTHNSETSAGSE----LGEAEQEGEGISER 1800
+K +L +AEG + +E KT S + E L E E ++ +
Sbjct: 419 EKGEELKKAEGKVRKEREYVIPKRNEIKENKTSVSAKFSAQEIKTGLKEVVTAVEEMTSK 478
Query: 1801 GETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDA 1860
G+ G + ED+ + ++D + +G ++ E EG+A + G+ +
Sbjct: 479 GKPGQEVL--EDDQENTLKYEYEEDFEVDEEKQGEKSNE-EGQADVQMNGIPQSPLDDKK 535
Query: 1861 QEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETE 1920
+ E + E+ +AP+A + E++ ESE E + K A +
Sbjct: 536 DNLDPEKESETSSQKAPDARDNVKDENDGCS----------ESELEEDKQDMKTASSTSS 585
Query: 1921 SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV--- 1977
++ EDE EA + T + SQE E +P +
Sbjct: 586 RSHPYSSDSEDESAVGDREA--------HTDSSTDESARRSSSQELSENDKPRKSHLPIE 637
Query: 1978 EALEVEVETQE-----AEGEAQPESEDVEAPEAEGEMQEAEE--EAQPESDGVEAQPKSE 2030
E+LE+E+E QE E + P E E EG + +E E E G + +
Sbjct: 638 ESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEGLSEKSGKHVSAEEK 697
Query: 2031 GEEAQEVEGETQKTEGDAQPESDGVE----------------------------APEAEE 2062
++ ++ E+ D + G+E A + +
Sbjct: 698 EKDKSKLWEESTAQVKDKKAGLPGLEEGGKDSLPLAYVLALGAPTMNFMVDETAAINSNK 757
Query: 2063 EAQEAEG-----EVQEA-EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI 2116
E+Q+ E +EA E + P+ D D + +GEA E EA A K
Sbjct: 758 ESQQLVQKTYTLEKKEAMEEDEAPQHRDADIVQGKGEAALWGEAGAVHEAPLRAWKPTA- 816
Query: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPE 2176
E PE E + E E E E+EGV + EG + P + A +
Sbjct: 817 EQPELAEEFTEKREIPPGIERGAEGAAEAEGVR-RLGEGGSDPIGQA---------AAKD 866
Query: 2177 LEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236
G+ EA + +E +A E + LE +A A E A E + A E
Sbjct: 867 AVGLSKDEAPEKQALMLTVLETDKAASEGEQGLE--KAVLANEAAALNLEHLHEVAALRE 924
Query: 2237 AQPESEGETQGEKKGSPQVSLGD-GQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQ 2295
A EGE +G V++ D G+SEE E+S + +
Sbjct: 925 AATSEEGEAEG------GVAVSDVGESEE--EASIDLED--------------------- 955
Query: 2296 TGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEA 2355
TGP AS ++D + +LG + R TR+ P + +E
Sbjct: 956 TGPMEDTASK-----REDGSEEAILGGEEPAKERK----EVMRTETRLSPFTGEAEASRM 1006
Query: 2356 PLGSRTPEQG--ASEGYDLQEDQALGSLAPTEAVGRADGFGQDD 2397
+ +PE+G A E + +ED + E V A+ +DD
Sbjct: 1007 QVSEGSPEEGSLAKEAFLCKED-----VEGEEMVTEAEANREDD 1045
Score = 60.8 bits (146), Expect = 2e-08
Identities = 74/338 (21%), Positives = 139/338 (41%), Gaps = 26/338 (7%)
Query: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
P+S ++ E E ++AEG+ + E E + + E + E+ ++ + QE +
Sbjct: 410 PKSRKEKSTEKGEELKKAEGKVRKEREYVIPKRNEIK-----ENKTSVSAKFSAQEIKTG 464
Query: 1993 AQPESEDVEAPEAEGEM-QEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
+ VE ++G+ QE E+ Q + E + E +E E +GE EG A +
Sbjct: 465 LKEVVTAVEEMTSKGKPGQEVLEDDQENTLKYEYEEDFEVDE--EKQGEKSNEEGQADVQ 522
Query: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQ 2111
+G+ +++ + E + E+ A +A + E++G E+E E
Sbjct: 523 MNGIPQSPLDDKKDNLDPEKES-------ETSSQKAPDARDNVKDENDG--CSESELEED 573
Query: 2112 KAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE-SEGIEAQEA- 2169
K + A T + P S E A G+ + ++ + A + E SE + +++
Sbjct: 574 KQDMKTASSTSSRSHPYSSDSEDESAVGDREAHTDSSTDESARRSSSQELSENDKPRKSH 633
Query: 2170 ---EEEAQPELEGVEAPEAEGEAQPE--SEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
EE + E+E E +A+ E +P E E EG + E E E++
Sbjct: 634 LPIEESLEIEIEDQEITKADVETKPMPIDESFENVLKEGTEKGTQEIAEG--LSEKSGKH 691
Query: 2225 PEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQS 2262
E + + + ES + + +K G P + G S
Sbjct: 692 VSAEEKEKDKSKLWEESTAQVKDKKAGLPGLEEGGKDS 729
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens]
Length = 436
Score = 111 bits (278), Expect = 7e-24
Identities = 102/379 (26%), Positives = 176/379 (46%), Gaps = 21/379 (5%)
Query: 1754 RDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEA-EQEGEGISERG---ETGGQGSG 1809
R+++ ++ E EG +E+EG+ E + G+ EQEG+ + G E GQ
Sbjct: 62 REQEGQVREQEGQV--REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 119
Query: 1810 HEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQP 1869
E ++ + +Q+ GQ EG + E EG+ + E EG + E EG +E EG+ +
Sbjct: 120 QEGQVREQEGQVREQE-GQVREQEG-QVREQEGQVR-EQEG-QVREQEGQVREQEGQVRE 175
Query: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEG 1929
+ V E EG+ + + + E + Q E G + + +K+ + E E + +
Sbjct: 176 QEGQVR--EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE 233
Query: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEA 1989
E E E + Q+ EE Q+ E Q + + E + QE + Q E + + E E Q
Sbjct: 234 EQMGEQE-EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 1990 EGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQ 2049
E E Q ++ + E E +M+E EE+ + + + + Q + E+ +++ QK + Q
Sbjct: 293 EQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQM--WEQKEQMWKQ 350
Query: 2050 PESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE 2109
E G E EE+ Q+ E +V++ E + + E + QE + Q E G E E GE
Sbjct: 351 EEQMG----EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMG-EQKEQMGE 405
Query: 2110 AQKAEGIEAPETEGEAQPE 2128
QK + E E GE + +
Sbjct: 406 -QKEQMREQEEQMGEQKEQ 423
Score = 110 bits (275), Expect = 2e-23
Identities = 108/437 (24%), Positives = 188/437 (43%), Gaps = 30/437 (6%)
Query: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895
E E E Q E + VE ++E E + + E++ + P+ E Q ++ + E
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQ---EGQVREQEGQVREQ 64
Query: 1896 EWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQ 1955
E +V+ + E E+E Q + + E EG+ E EG + +E E +E EGQ +
Sbjct: 65 EGQVREQ----EGQVREQEGQVREQEGQVREQEGQVR-EQEG-QVREQEGQVREQEGQVR 118
Query: 1956 PESEVIESQEA---EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEA 2012
+ + QE E+E Q ++ + E E + +E EG+ + + V E EG+++E
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR--EQEGQVREQ 176
Query: 2013 EEEAQPESDGVEAQPKSEGE-EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEV 2071
E + + + V Q GE E Q E E Q E + Q + + E EE+ ++ E ++
Sbjct: 177 EGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQM 236
Query: 2072 QEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEG 2131
E E + + E V QE + Q E + + + E E + + E
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQ------------MREQEEQMREQEEQMLKQKEQ 284
Query: 2132 IEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGV-EAPEAEGEAQ 2190
E E GE + + E Q E E Q + + +E EE+ + E + E E E +
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Query: 2191 PESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250
+ E E E Q + + + + EE+ + + E + E + Q E GE Q E+
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGE-QKEQM 403
Query: 2251 GSPQVSLGDGQSEEASE 2267
G + + + Q E+ E
Sbjct: 404 GEQKEQMRE-QEEQMGE 419
Score = 109 bits (273), Expect = 3e-23
Identities = 95/392 (24%), Positives = 177/392 (45%), Gaps = 26/392 (6%)
Query: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEA---EGEAQPESEDVETPEAEWEVQPES 1903
E++ + P+ EG +E EG+ + + V E E E Q ++ + E E +V+ +
Sbjct: 42 ETDKIPLPQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ- 99
Query: 1904 EGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIES 1963
E E+E Q + + E EG+ E EG + +E E +E EGQ + + +
Sbjct: 100 ---EGQVREQEGQVREQEGQVREQEGQVR-EQEG-QVREQEGQVREQEGQVREQEGQVRE 154
Query: 1964 QEA---EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPES 2020
QE E+E Q ++ + E E + +E EG+ + ++ + E EG+M E EE+ +
Sbjct: 155 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVR--EQEGQMGEQEGQMGEQEEQMGEQE 212
Query: 2021 DGVEAQPKSEGEEAQEV--------EGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQ 2072
+ ++ Q + GE+ +++ E E Q + + Q + + + EE+ +E E +++
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMR 272
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGE--AQPESE 2130
E E + + E + +E GE + + E E E Q E E + E + E +
Sbjct: 273 EQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQ 332
Query: 2131 GIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQ 2190
E E E + + E Q E E Q + + + ++ EE+ + + E + E + Q
Sbjct: 333 MWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQ 392
Query: 2191 PESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
E G E E GE + ++ E E++ Q
Sbjct: 393 EEQMG-EQKEQMGEQKEQMREQEEQMGEQKEQ 423
Score = 104 bits (260), Expect = 9e-22
Identities = 111/429 (25%), Positives = 190/429 (44%), Gaps = 42/429 (9%)
Query: 1747 EGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEA-EQEGEGISERGETGG 1805
E ++L DK P E + +E+EG+ E + G+ EQEG+ + G+
Sbjct: 36 ELKRKLETDKIPLPQEGQ----VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 91
Query: 1806 QGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEG 1865
Q +G+ + GQ EG + E EG+ + E EG + E EG +E EG
Sbjct: 92 Q--------EGQVR----EQEGQVREQEG-QVREQEGQVR-EQEG-QVREQEGQVREQEG 136
Query: 1866 EAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEAL 1925
+ + + V E E Q ++ + E E +V+ + E E+E Q + +
Sbjct: 137 QVREQEGQVR----EQEGQVREQEGQVREQEGQVREQ----EGQVREQEGQVREQEGQVR 188
Query: 1926 ETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVE 1985
E EG+ E EG + E EE E E Q Q + E Q E+E Q ++ + E E +
Sbjct: 189 EQEGQ-MGEQEG-QMGEQEEQMGEQEEQMQKQEE----QMGEQEEQMRKQEEQMGEQEEQ 242
Query: 1986 TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTE 2045
Q+ E + Q + E + + E +M+E EE+ + + + + Q + +E Q E E Q E
Sbjct: 243 VQKQEEQVQKQEEQMR--KQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300
Query: 2046 GDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE 2105
+ Q + E EE+ +E E ++ + E + + E + Q+ + Q E G E
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMG----E 356
Query: 2106 AEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIE 2165
E + QK E + + E + + + E + E + Q E G E ++ GE + + E
Sbjct: 357 QEEQMQKQEE-QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMG-EQKEQMGEQKEQMREQE 414
Query: 2166 AQEAEEEAQ 2174
Q E++ Q
Sbjct: 415 EQMGEQKEQ 423
Score = 54.3 bits (129), Expect = 1e-06
Identities = 50/231 (21%), Positives = 100/231 (43%), Gaps = 14/231 (6%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E E + +E++ EQ+ + Q Q E+ ++ E G QEE VQ +E + ++ +
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEE 255
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGE---GLQEEGV--------QLEEVKEGP 1381
+ Q E+ +E E + +++EE L++ E+T E G QEE + + EE
Sbjct: 256 QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQ 315
Query: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEP 1441
E ++ + + G +EE + E+ ++ + + + ++++ +Q++E +
Sbjct: 316 EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQM 375
Query: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQ 1492
E E E + Q G Q E E+ MG++ Q
Sbjct: 376 RKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQ---EEQMGEQKEQ 423
Score = 49.3 bits (116), Expect = 5e-05
Identities = 43/160 (26%), Positives = 76/160 (47%), Gaps = 4/160 (2%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E E + +E + Q+ E Q Q E+ ++ E G QEE ++ +E + G Q
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQE--EQMGEQ 239
Query: 1333 EEGVQ-LEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALE 1391
EE VQ EE + + E +++E Q+ E EE E ++ Q E+ ++ + G Q E +
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299
Query: 1392 EGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEE 1431
E +E+ +E + QE + G QE+ +++E
Sbjct: 300 E-QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKE 338
Score = 47.4 bits (111), Expect = 2e-04
Identities = 39/142 (27%), Positives = 71/142 (50%), Gaps = 19/142 (13%)
Query: 1271 TNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEG 1330
T E E + +E++ EQ+ E +E+++ +E + G + E + E+ Q+ E K +
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQ--EEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348
Query: 1331 LQEE--GVQLEETKETEGEGQQEE-------------EAQLEEIEETGGEGLQEEGVQLE 1375
QEE G Q E+ ++ E + +++E E Q+ + EE GE ++ G Q E
Sbjct: 349 KQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKE 408
Query: 1376 EVKEGPEGGLQGEALEEGLKEE 1397
+++E E GE E+ K+E
Sbjct: 409 QMREQEE--QMGEQKEQMRKQE 428
Score = 45.1 bits (105), Expect = 9e-04
Identities = 46/166 (27%), Positives = 80/166 (48%), Gaps = 10/166 (6%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E E + +E + Q+ E Q Q + +E EG+ ++E+ Q+ E + + G Q
Sbjct: 147 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQ-VREQEGQMGEQEGQMGEQ 204
Query: 1333 EEGV-QLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEV---KEGPEGGLQGE 1388
EE + + EE + + E E+E Q+ + EE GE QEE VQ +E K+ + Q E
Sbjct: 205 EEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE--QEEQVQKQEEQVQKQEEQMRKQEE 262
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGR 1434
+ E +EE + E+ ++ + + G QE+ ++EE R
Sbjct: 263 QMRE--QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Score = 45.1 bits (105), Expect = 9e-04
Identities = 36/161 (22%), Positives = 79/161 (49%), Gaps = 3/161 (1%)
Query: 1277 ERDSEEQRASSNLEQLAENTVQEEVQL--EETKEGTEGEGLQEEAVQLEETKTEEGLQEE 1334
E++ + + + + ++E Q+ +E + G + E + E+ Q+++ + + G QEE
Sbjct: 168 EQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227
Query: 1335 GVQLEETKETEGEGQ-QEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEG 1393
++ +E + E E Q Q++E Q+++ EE + ++ Q E+++E E L+ + E
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ 287
Query: 1394 LKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGR 1434
++ G EE +E + +E QEE+ G+
Sbjct: 288 EEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGK 328
Score = 42.7 bits (99), Expect = 0.004
Identities = 75/346 (21%), Positives = 135/346 (39%), Gaps = 34/346 (9%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E E + +E + Q+ E Q Q + +E EG+ ++E+ Q+ E + + Q
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQ-VREQEGQVREQEGQVREQ 162
Query: 1333 EEGVQLEETKETEGEGQ-QEEEAQLEEIEETGGE-----GLQEE--GVQLEEV-KEGPEG 1383
E V+ +E + E EGQ +E+E Q+ E E GE G QEE G Q E++ K+ +
Sbjct: 163 EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQM 222
Query: 1384 GLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCP 1443
G Q E + + ++ G EE V QE + QE+ ++EE R
Sbjct: 223 GEQEEQMRKQEEQMGEQEE-QVQKQEEQVQKQEEQMRKQEEQMREQEEQMR--------- 272
Query: 1444 AEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERS 1503
+ L + + + E Q+G Q E E+ M QE + + E+
Sbjct: 273 -------EQEEQMLKQKEQTEQEEQTGEQEEQMREQE--EQMREQEEQMREQEEQMREQE 323
Query: 1504 SSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQD 1563
+ + +W +K + + E + Q+ + Q +Q+
Sbjct: 324 EQMGKQE----EQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQE 379
Query: 1564 VAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHR 1609
R Q+ R+ ++ G + E + E + Q+ + R
Sbjct: 380 EQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Score = 42.7 bits (99), Expect = 0.004
Identities = 41/166 (24%), Positives = 84/166 (50%), Gaps = 11/166 (6%)
Query: 1273 EDEAERDSEEQRASSNLE-QLAENTVQEEVQLEETKEGT--EGEGLQEEAVQLEETKTEE 1329
++E R+ EEQ + + E T ++E Q+ E +E + E ++E+ Q+ E + +
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQM 326
Query: 1330 GLQEEGVQLEETKETEGEGQQE---EEAQLEEIEETGGEGLQEEGV-QLEEVKEGPEGGL 1385
G QEE Q+ E KE E +++ +E Q+ E EE + QEE V + EE E +
Sbjct: 327 GKQEE--QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQK--QEEQVRKQEEQMRKQEEQM 382
Query: 1386 QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEE 1431
+ + + +EE + E+ G++ + + + ++ + ++++E
Sbjct: 383 RKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQE 428
Score = 37.4 bits (85), Expect = 0.18
Identities = 25/93 (26%), Positives = 47/93 (50%), Gaps = 1/93 (1%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E + + +E++ EQ+ + Q Q E+ ++ E QEE ++ +E + E +
Sbjct: 342 EQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGE 1365
+ G Q E+ +E E E E++ Q+ + EE GE
Sbjct: 402 QMGEQKEQMREQE-EQMGEQKEQMRKQEEHMGE 433
Score = 33.5 bits (75), Expect = 2.6
Identities = 21/81 (25%), Positives = 41/81 (50%), Gaps = 1/81 (1%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E E + +E++ EQ+ + Q Q E+ ++ E G Q+E + ++ + E +
Sbjct: 356 EQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEE 415
Query: 1333 EEGVQLEE-TKETEGEGQQEE 1352
+ G Q E+ K+ E G+Q+E
Sbjct: 416 QMGEQKEQMRKQEEHMGEQKE 436
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 109 bits (273), Expect = 3e-23
Identities = 117/443 (26%), Positives = 191/443 (43%), Gaps = 43/443 (9%)
Query: 1835 IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPE 1894
+EAP+ + + + E +E + E + E E +E++ E + + E E PE
Sbjct: 441 VEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE 500
Query: 1895 AEWE---VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAE 1951
AE E + A APE KE + E E E E E+E E EGA++ +AEE E E
Sbjct: 501 AEEEEVAAKKSPVKATAPEV-KEEEGEKEEEEGQE---EEEEEDEGAKSDQAEEGGSEKE 556
Query: 1952 GQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES----------EDVE 2001
G + E E E +E E EA+ E E+ EA E + +++E A E E +
Sbjct: 557 GSS--EKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 614
Query: 2002 APEAEGEMQEAEEEAQP----ESDGVEAQPKSEGEE------AQEVEGETQKTEGDAQPE 2051
+P + ++E + P E G PKS EE + E K+ P
Sbjct: 615 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 674
Query: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQ 2111
+ ++P + +EA+ + + +GE E E+ + +EA E + E + E P+ E +
Sbjct: 675 EEKAKSPVPKSPVEEAKSKAEVGKGE-QKEEEEKEVKEAPKEEKVEKK-EEKPKDVPEKK 732
Query: 2112 KAEGIEAPETEGEAQPESEGIEA---PEAEGEAQPESEGVEAQDAEGEAQPESEGIE--- 2165
KAE E E ++ ++ E + E +P + E + A GE E EG +
Sbjct: 733 KAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGA 792
Query: 2166 --AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQP 2223
+++ + E+EG E E E E + + G E E +G L+ A E + +
Sbjct: 793 KGSRKEDIAVNGEVEGKE--EVEQETKEKGSGRE--EEKGVVTNGLDLSPADEKKGGDKS 848
Query: 2224 EPEGVETPEAEGEAQPESEGETQ 2246
E + V T E +G T+
Sbjct: 849 EEKVVVTKTVEKITSEGGDGATK 871
Score = 100 bits (250), Expect = 1e-20
Identities = 100/384 (26%), Positives = 169/384 (44%), Gaps = 23/384 (5%)
Query: 1907 EAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966
EAP+ + + + E +E ET+ EDE +E +EA A E + E + ++E
Sbjct: 442 EAPKLKVQHKFVEEIIE--ETKVEDEK----SEMEEALTAITEELAVSMKEEKKEAAEEK 495
Query: 1967 EEEAQPESEDVEALEVEV-----ETQEAEGEAQPES-EDVEAPEAEGEMQEAEEEAQPES 2020
EEE + E E+V A + V E +E EGE + E ++ E E EG + EE E
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555
Query: 2021 DGVEAQPKSEGEEAQ---EVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGE 2077
+G + + E EE + E EGE + + + + E E EE +A+ E E
Sbjct: 556 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 615
Query: 2078 AHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEA 2137
P+S + ++ P E ++P + ++ P++ E + +S ++P
Sbjct: 616 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 675
Query: 2138 EGEAQPESEGVEAQDAEGEAQ-PESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGI 2196
E P + ++A+ +A+ + E E +E E + P+ E VE E + + PE +
Sbjct: 676 EKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 734
Query: 2197 EAP---EAEGEAQPELEGVEA---PEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250
E+P EA E + V+ E +EE +P + E +A GE E EG +G K
Sbjct: 735 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG 794
Query: 2251 GSPQVSLGDGQSEEASESSSPVPE 2274
+ +G+ E E E
Sbjct: 795 SRKEDIAVNGEVEGKEEVEQETKE 818
Score = 97.8 bits (242), Expect = 1e-19
Identities = 120/478 (25%), Positives = 208/478 (43%), Gaps = 46/478 (9%)
Query: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
P + ++ Q+ + A + + Q + E+IE + E+E E + A+ E+ E +
Sbjct: 429 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 488
Query: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA---QPKSEGEEAQEVEGETQKTEGDAQ 2049
+ E E PEAE EEE + V+A + K E E +E EG+ ++ E D
Sbjct: 489 KEAAEEKEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 542
Query: 2050 PESDGVEAPEAEEE--AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE-- 2105
+SD E +E+E +++ EGE +E E EA E E+ +A+E E + + +SE V E
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE-EKKVEEKSEEVATKEEL 601
Query: 2106 -AEGEAQKAEGIEA--PETEGEAQPESEGIEAP-EAEGEAQPESEGVEAQDAEGEAQPES 2161
A+ + +K E ++ P++ E + +S ++P E +G++ VE + P+S
Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK--SPVPKS 659
Query: 2162 EGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEA 2221
E ++ P E ++P + + E + E + + E E EAP+ E+
Sbjct: 660 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 719
Query: 2222 QPEPEGVETPE---AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPT 2278
+ E + + PE AE + E+ E K S +V L +E E P+ +++
Sbjct: 720 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITK-SVKVHL----EKETKEEGKPLQQEK-- 772
Query: 2279 PPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLG-DTRSPDAKSTGTPHAE 2337
GG+ + GS G SR + + N V G + + K G+ E
Sbjct: 773 EKEKAGGEGGSEEEGSDKGAKGSRK-------EDIAVNGEVEGKEEVEQETKEKGSGREE 825
Query: 2338 RK--ATRMYPESSTSEQ------EEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAV 2387
K T S E+ EE + ++T E+ SEG D S+ T+ V
Sbjct: 826 EKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 883
Score = 95.1 bits (235), Expect = 7e-19
Identities = 104/431 (24%), Positives = 187/431 (43%), Gaps = 40/431 (9%)
Query: 1848 SEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAE 1907
S ++ P+ E A + + + + E +E + E E E + E V + E E
Sbjct: 433 SSKIQKPKVE--APKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKE 490
Query: 1908 APEAEKEAQPETESVEALETEGEDE---PESEGAEAQEAEEAAQEAEGQTQPESEVIESQ 1964
A E EKE +PE E E + + PE + E ++ EE QE E + E E +S
Sbjct: 491 AAE-EKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE---EEEDEGAKSD 546
Query: 1965 EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVE 2024
+AEE + E + E E +E E EA+ E E+ EA E + +++EE A E E
Sbjct: 547 QAEEGGSEKEGSSE--KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE----E 600
Query: 2025 AQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESED 2084
++ E+ ++ + K+ + + +S ++P E+ E +G++
Sbjct: 601 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP 660
Query: 2085 VDAQ----------EAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEA 2134
V+ + E + ++ VE +++ E K E E E E + P+ E +E
Sbjct: 661 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 720
Query: 2135 PEAEGEAQPESEGVEA---QDAEGEAQPESEGIEA---QEAEEEAQPELEGVEAPEAEGE 2188
E + + PE + E+ ++A E ++ ++ +E +EE +P + E +A GE
Sbjct: 721 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 780
Query: 2189 AQPESEGIE-----APEAEGEAQPELEGVEAPEAEEE----AQPEPEGVETPEAEGEAQP 2239
E EG + + + + E+EG E E E + + E +GV T +
Sbjct: 781 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD 840
Query: 2240 ESEGETQGEKK 2250
E +G + E+K
Sbjct: 841 EKKGGDKSEEK 851
Score = 87.4 bits (215), Expect = 2e-16
Identities = 90/361 (24%), Positives = 157/361 (43%), Gaps = 26/361 (7%)
Query: 1752 LNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHE 1811
+ +K E E + A+E E S A + + E+EGE E G+ + E
Sbjct: 484 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVK-EEEGEKEEEEGQEEEEEED-E 541
Query: 1812 DNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPES 1871
+A GG + G S+ EG + EGE + E+EG EA E E + E
Sbjct: 542 GAKSDQAEEGGSEKEGSSEKEEG---EQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 598
Query: 1872 EDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGED 1931
E++ A +A+ E +PE P++ E + +S ++P EK P +S +E +G+
Sbjct: 599 EELVA-DAKVE-KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS--PVEEKGKS 654
Query: 1932 ----EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV----- 1982
P E ++ ++ +E P+S V E++ E + E ++ E EV
Sbjct: 655 PVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK 714
Query: 1983 --EVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040
+VE +E + + PE + E+P E + E + +E + K EG+ Q+ E E
Sbjct: 715 EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ-EKE 773
Query: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
+K G+ E +G +++ A+ + E GE + E + +G + E +G
Sbjct: 774 KEKAGGEGGSEEEG-----SDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKG 828
Query: 2101 V 2101
V
Sbjct: 829 V 829
Score = 72.8 bits (177), Expect = 4e-12
Identities = 90/383 (23%), Positives = 155/383 (40%), Gaps = 40/383 (10%)
Query: 1696 KRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRD 1755
++ E + E EVA K+ T+ P + + G E E+G+ + D
Sbjct: 494 EKEEEPEAEEEEVAAKKSPVKATA------------PEVKEEEGEKEEEEGQEEEE-EED 540
Query: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQ 1815
+ K +AE E+EG + E EAE EGE + E + E +
Sbjct: 541 EGAKSDQAEEGG--SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 598
Query: 1816 GEAAAGGDQDPGQSDGAEGIEAP-EAEGEA----QPESEGVEAPEAEGDAQEAEGEAQPE 1870
E A + + + ++P E +G++ P E ++P + +E P+
Sbjct: 599 EELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 658
Query: 1871 SEDVEAPEAEGEAQPESEDVETPEAEWEVQPE------SEGAEAPEAEKEAQ--PETESV 1922
S E ++ P E ++P + V+ +G + E EKE + P+ E V
Sbjct: 659 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 718
Query: 1923 EALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV 1982
E E + +D PE + AE+ EEA E T+ +E +E +EE +P L+
Sbjct: 719 EKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE-KETKEEGKP-------LQQ 770
Query: 1983 EVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPE-SDGVEAQPKSEGEEAQEVEGET 2041
E E ++A GE E E + ++ + E + VE + K +G +E +G
Sbjct: 771 EKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVV 830
Query: 2042 QKTEG-DAQPESDGVEAPEAEEE 2063
T G D P + ++EE+
Sbjct: 831 --TNGLDLSPADEKKGGDKSEEK 851
Score = 53.5 bits (127), Expect = 2e-06
Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 20/215 (9%)
Query: 1268 ACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV---QLEE 1324
A E+E E + EE A + + V+EE +E +EG E E ++E Q EE
Sbjct: 491 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550
Query: 1325 TKTEE---GLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP 1381
+E+ +EEG Q E E E EG++ E + +++EE E +E + + E P
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610
Query: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSP------DGKGSQEDDPVQEEEAGRA 1435
E + + ++E+G +E ++ P GK PV EE G++
Sbjct: 611 EKA-KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV--EEKGKS 667
Query: 1436 SASAEPCPAEGTEEPTEPPSHLSETDPSASERQSG 1470
S P EE + P S + + S+ + G
Sbjct: 668 PVSKSP-----VEEKAKSPVPKSPVEEAKSKAEVG 697
Score = 51.6 bits (122), Expect = 9e-06
Identities = 66/250 (26%), Positives = 107/250 (42%), Gaps = 39/250 (15%)
Query: 1275 EAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLE--------ETK 1326
E E+ E+ ++ E+LA + +E+ + E KE E E +EE + E K
Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE-EEPEAEEEEVAAKKSPVKATAPEVK 521
Query: 1327 TEEGLQEEGVQLEETKETEGEGQQEEE-AQLEEIEETG----GEGLQEEGVQLEEVKEGP 1381
EEG +EE +E + E ++E+E A+ ++ EE G G +EEG Q E E
Sbjct: 522 EEEGEKEE-------EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 574
Query: 1382 EGGLQGEALEEGLKEEGLPEEGS-------VHGQELSEASSPDGKGSQED---DPVQE-- 1429
G + EA EE EE E + ++ +A SP K E+ PV +
Sbjct: 575 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP 634
Query: 1430 -EEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQ 1488
EE G++ P P EE + P S + S S +E + P + + +
Sbjct: 635 VEEKGKS-----PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 689
Query: 1489 EHTQAQPTQG 1498
++A+ +G
Sbjct: 690 AKSKAEVGKG 699
Score = 50.8 bits (120), Expect = 2e-05
Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 24/217 (11%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E+ E E S E L T + V ++E K+ E +E+ + E + E +
Sbjct: 454 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK----EAAEEKEEEPEAEEEEVAAK 509
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
+ V+ + E EG++EEE EE EE ++EG + ++ + EGG + E E
Sbjct: 510 KSPVKATAPEVKEEEGEKEEEEGQEEEEE------EDEGAKSDQAE---EGGSEKEGSSE 560
Query: 1393 GLKEEGLPEEGSVHGQ-ELSEASSPDGKGSQE--------DDPVQEEEAGRASASAEPCP 1443
KEEG EEG + E EA + + K +E ++ V + + + + P P
Sbjct: 561 --KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 618
Query: 1444 AEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKP 1480
EE + P S + S +E + P
Sbjct: 619 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 655
Score = 48.5 bits (114), Expect = 8e-05
Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 27/201 (13%)
Query: 1258 FPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQE 1317
F TF + T+ S+ Q+ +L E +EETK E ++E
Sbjct: 412 FSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEE 471
Query: 1318 EAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEE--------EAQLEEIEETGGEGLQE 1369
+ E + ++EE + E KE E E ++EE +A E++E GE +E
Sbjct: 472 ALTAITE-ELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
Query: 1370 EGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQE 1429
EG +E +E + G + + EEG G +EGS +E G QE+ +
Sbjct: 531 EG---QEEEEEEDEGAKSDQAEEG----GSEKEGSSEKEE----------GEQEEGETEA 573
Query: 1430 EEAG-RASASAEPCPAEGTEE 1449
E G A A E E +EE
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEE 594
Score = 45.4 bits (106), Expect = 7e-04
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 23/173 (13%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
+ +AE EQ+ E + E +E+V+ +E K E + E+ EE E
Sbjct: 691 KSKAEVGKGEQKEEEEKE-VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI 749
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
+ V++ KET+ EG+ + Q +E E+ GGEG EE EG + G +G
Sbjct: 750 TKSVKVHLEKETKEEGKPLQ--QEKEKEKAGGEGGSEE--------EGSDKGAKGS---- 795
Query: 1393 GLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAE 1445
++E + G V G+E E + + KGS +EEE G + + PA+
Sbjct: 796 --RKEDIAVNGEVEGKEEVEQETKE-KGSG-----REEEKGVVTNGLDLSPAD 840
Score = 40.8 bits (94), Expect = 0.016
Identities = 45/224 (20%), Positives = 97/224 (43%), Gaps = 13/224 (5%)
Query: 1294 ENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEE 1353
++ V+E+ + K E +G + E K + + + V+ ++K G+G+Q+EE
Sbjct: 645 KSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEE 704
Query: 1354 AQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQ---EL 1410
+ +E++E E ++E+ +E P+ + + E +KEE + E ++ L
Sbjct: 705 EE-KEVKEAPKE------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHL 757
Query: 1411 SEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTE-EPTEPPSHLSETDPSASERQS 1469
+ + +GK Q++ ++E+AG S E +G + E + E + Q
Sbjct: 758 EKETKEEGKPLQQEK--EKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE 815
Query: 1470 GSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALD 1513
+ G E+ G G + + A +G + V + ++
Sbjct: 816 TKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 859
Score = 35.4 bits (80), Expect = 0.68
Identities = 60/258 (23%), Positives = 99/258 (38%), Gaps = 30/258 (11%)
Query: 1668 SPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAE 1727
SP+ KA + P++EA ++ + ++ E + E E AP + + + E
Sbjct: 672 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE-APKEEKVEKKEEKPKDVPE 730
Query: 1728 GGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSEL 1787
+ V E S +++ +K+ K EG + QE+E + AG E
Sbjct: 731 KKKAESPVKEEAVAEVVTITKSVKVHLEKETK---EEGKPLQQEKE------KEKAGGE- 780
Query: 1788 GEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAE-GEAQP 1846
G +E+EG + G +GS ED G+ +G E +E E G +
Sbjct: 781 GGSEEEG------SDKGAKGSRKEDIAVN----------GEVEGKEEVEQETKEKGSGRE 824
Query: 1847 ESEGVEAPEAE-GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E +GV + A E +G + E + V E + E D T V +
Sbjct: 825 EEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE-KITSEGGDGATKYITKSVTVTQKV 883
Query: 1906 AEAPEAEKEAQPETESVE 1923
E E +E T+ VE
Sbjct: 884 EEHEETFEEKLVSTKKVE 901
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
sapiens]
Length = 540
Score = 109 bits (273), Expect = 3e-23
Identities = 117/443 (26%), Positives = 191/443 (43%), Gaps = 43/443 (9%)
Query: 1835 IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPE 1894
+EAP+ + + + E +E + E + E E +E++ E + + E E PE
Sbjct: 65 VEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPE 124
Query: 1895 AEWE---VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAE 1951
AE E + A APE KE + E E E E E+E E EGA++ +AEE E E
Sbjct: 125 AEEEEVAAKKSPVKATAPEV-KEEEGEKEEEEGQE---EEEEEDEGAKSDQAEEGGSEKE 180
Query: 1952 GQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPES----------EDVE 2001
G + E E E +E E EA+ E E+ EA E + +++E A E E +
Sbjct: 181 GSS--EKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 238
Query: 2002 APEAEGEMQEAEEEAQP----ESDGVEAQPKSEGEE------AQEVEGETQKTEGDAQPE 2051
+P + ++E + P E G PKS EE + E K+ P
Sbjct: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 298
Query: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQ 2111
+ ++P + +EA+ + + +GE E E+ + +EA E + E + E P+ E +
Sbjct: 299 EEKAKSPVPKSPVEEAKSKAEVGKGE-QKEEEEKEVKEAPKEEKVEKK-EEKPKDVPEKK 356
Query: 2112 KAEGIEAPETEGEAQPESEGIEA---PEAEGEAQPESEGVEAQDAEGEAQPESEGIE--- 2165
KAE E E ++ ++ E + E +P + E + A GE E EG +
Sbjct: 357 KAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGA 416
Query: 2166 --AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQP 2223
+++ + E+EG E E E E + + G E E +G L+ A E + +
Sbjct: 417 KGSRKEDIAVNGEVEGKE--EVEQETKEKGSGRE--EEKGVVTNGLDLSPADEKKGGDKS 472
Query: 2224 EPEGVETPEAEGEAQPESEGETQ 2246
E + V T E +G T+
Sbjct: 473 EEKVVVTKTVEKITSEGGDGATK 495
Score = 100 bits (250), Expect = 1e-20
Identities = 100/384 (26%), Positives = 169/384 (44%), Gaps = 23/384 (5%)
Query: 1907 EAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966
EAP+ + + + E +E ET+ EDE +E +EA A E + E + ++E
Sbjct: 66 EAPKLKVQHKFVEEIIE--ETKVEDEK----SEMEEALTAITEELAVSMKEEKKEAAEEK 119
Query: 1967 EEEAQPESEDVEALEVEV-----ETQEAEGEAQPES-EDVEAPEAEGEMQEAEEEAQPES 2020
EEE + E E+V A + V E +E EGE + E ++ E E EG + EE E
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 2021 DGVEAQPKSEGEEAQ---EVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGE 2077
+G + + E EE + E EGE + + + + E E EE +A+ E E
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
Query: 2078 AHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEA 2137
P+S + ++ P E ++P + ++ P++ E + +S ++P
Sbjct: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
Query: 2138 EGEAQPESEGVEAQDAEGEAQ-PESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGI 2196
E P + ++A+ +A+ + E E +E E + P+ E VE E + + PE +
Sbjct: 300 EKAKSPVPKS-PVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
Query: 2197 EAP---EAEGEAQPELEGVEA---PEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK 2250
E+P EA E + V+ E +EE +P + E +A GE E EG +G K
Sbjct: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG 418
Query: 2251 GSPQVSLGDGQSEEASESSSPVPE 2274
+ +G+ E E E
Sbjct: 419 SRKEDIAVNGEVEGKEEVEQETKE 442
Score = 97.8 bits (242), Expect = 1e-19
Identities = 120/478 (25%), Positives = 208/478 (43%), Gaps = 46/478 (9%)
Query: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
P + ++ Q+ + A + + Q + E+IE + E+E E + A+ E+ E +
Sbjct: 53 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 112
Query: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEA---QPKSEGEEAQEVEGETQKTEGDAQ 2049
+ E E PEAE EEE + V+A + K E E +E EG+ ++ E D
Sbjct: 113 KEAAEEKEEEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 166
Query: 2050 PESDGVEAPEAEEE--AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE-- 2105
+SD E +E+E +++ EGE +E E EA E E+ +A+E E + + +SE V E
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE-EKKVEEKSEEVATKEEL 225
Query: 2106 -AEGEAQKAEGIEA--PETEGEAQPESEGIEAP-EAEGEAQPESEGVEAQDAEGEAQPES 2161
A+ + +K E ++ P++ E + +S ++P E +G++ VE + P+S
Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGK--SPVPKS 283
Query: 2162 EGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEA 2221
E ++ P E ++P + + E + E + + E E EAP+ E+
Sbjct: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
Query: 2222 QPEPEGVETPE---AEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPT 2278
+ E + + PE AE + E+ E K S +V L +E E P+ +++
Sbjct: 344 KKEEKPKDVPEKKKAESPVKEEAVAEVVTITK-SVKVHL----EKETKEEGKPLQQEK-- 396
Query: 2279 PPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLG-DTRSPDAKSTGTPHAE 2337
GG+ + GS G SR + + N V G + + K G+ E
Sbjct: 397 EKEKAGGEGGSEEEGSDKGAKGSRK-------EDIAVNGEVEGKEEVEQETKEKGSGREE 449
Query: 2338 RK--ATRMYPESSTSEQ------EEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAV 2387
K T S E+ EE + ++T E+ SEG D S+ T+ V
Sbjct: 450 EKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYITKSVTVTQKV 507
Score = 95.1 bits (235), Expect = 7e-19
Identities = 104/431 (24%), Positives = 187/431 (43%), Gaps = 40/431 (9%)
Query: 1848 SEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAE 1907
S ++ P+ E A + + + + E +E + E E E + E V + E E
Sbjct: 57 SSKIQKPKVE--APKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKE 114
Query: 1908 APEAEKEAQPETESVEALETEGEDE---PESEGAEAQEAEEAAQEAEGQTQPESEVIESQ 1964
A E EKE +PE E E + + PE + E ++ EE QE E + E E +S
Sbjct: 115 AAE-EKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEE---EEEDEGAKSD 170
Query: 1965 EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVE 2024
+AEE + E + E E +E E EA+ E E+ EA E + +++EE A E E
Sbjct: 171 QAEEGGSEKEGSSE--KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE----E 224
Query: 2025 AQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESED 2084
++ E+ ++ + K+ + + +S ++P E+ E +G++
Sbjct: 225 LVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP 284
Query: 2085 VDAQ----------EAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEA 2134
V+ + E + ++ VE +++ E K E E E E + P+ E +E
Sbjct: 285 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 344
Query: 2135 PEAEGEAQPESEGVEA---QDAEGEAQPESEGIEA---QEAEEEAQPELEGVEAPEAEGE 2188
E + + PE + E+ ++A E ++ ++ +E +EE +P + E +A GE
Sbjct: 345 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404
Query: 2189 AQPESEGIE-----APEAEGEAQPELEGVEAPEAEEE----AQPEPEGVETPEAEGEAQP 2239
E EG + + + + E+EG E E E + + E +GV T +
Sbjct: 405 GGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPAD 464
Query: 2240 ESEGETQGEKK 2250
E +G + E+K
Sbjct: 465 EKKGGDKSEEK 475
Score = 87.4 bits (215), Expect = 2e-16
Identities = 90/361 (24%), Positives = 157/361 (43%), Gaps = 26/361 (7%)
Query: 1752 LNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHE 1811
+ +K E E + A+E E S A + + E+EGE E G+ + E
Sbjct: 108 MKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVK-EEEGEKEEEEGQEEEEEED-E 165
Query: 1812 DNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPES 1871
+A GG + G S+ EG + EGE + E+EG EA E E + E
Sbjct: 166 GAKSDQAEEGGSEKEGSSEKEEG---EQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 222
Query: 1872 EDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGED 1931
E++ A +A+ E +PE P++ E + +S ++P EK P +S +E +G+
Sbjct: 223 EELVA-DAKVE-KPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS--PVEEKGKS 278
Query: 1932 ----EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV----- 1982
P E ++ ++ +E P+S V E++ E + E ++ E EV
Sbjct: 279 PVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK 338
Query: 1983 --EVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040
+VE +E + + PE + E+P E + E + +E + K EG+ Q+ E E
Sbjct: 339 EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQ-EKE 397
Query: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEG 2100
+K G+ E +G +++ A+ + E GE + E + +G + E +G
Sbjct: 398 KEKAGGEGGSEEEG-----SDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKG 452
Query: 2101 V 2101
V
Sbjct: 453 V 453
Score = 72.8 bits (177), Expect = 4e-12
Identities = 90/383 (23%), Positives = 155/383 (40%), Gaps = 40/383 (10%)
Query: 1696 KRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRD 1755
++ E + E EVA K+ T+ P + + G E E+G+ + D
Sbjct: 118 EKEEEPEAEEEEVAAKKSPVKATA------------PEVKEEEGEKEEEEGQEEEE-EED 164
Query: 1756 KDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQ 1815
+ K +AE E+EG + E EAE EGE + E + E +
Sbjct: 165 EGAKSDQAEEGG--SEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATK 222
Query: 1816 GEAAAGGDQDPGQSDGAEGIEAP-EAEGEA----QPESEGVEAPEAEGDAQEAEGEAQPE 1870
E A + + + ++P E +G++ P E ++P + +E P+
Sbjct: 223 EELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 282
Query: 1871 SEDVEAPEAEGEAQPESEDVETPEAEWEVQPE------SEGAEAPEAEKEAQ--PETESV 1922
S E ++ P E ++P + V+ +G + E EKE + P+ E V
Sbjct: 283 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 342
Query: 1923 EALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV 1982
E E + +D PE + AE+ EEA E T+ +E +E +EE +P L+
Sbjct: 343 EKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLE-KETKEEGKP-------LQQ 394
Query: 1983 EVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPE-SDGVEAQPKSEGEEAQEVEGET 2041
E E ++A GE E E + ++ + E + VE + K +G +E +G
Sbjct: 395 EKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVV 454
Query: 2042 QKTEG-DAQPESDGVEAPEAEEE 2063
T G D P + ++EE+
Sbjct: 455 --TNGLDLSPADEKKGGDKSEEK 475
Score = 53.5 bits (127), Expect = 2e-06
Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 20/215 (9%)
Query: 1268 ACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV---QLEE 1324
A E+E E + EE A + + V+EE +E +EG E E ++E Q EE
Sbjct: 115 AAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 1325 TKTEE---GLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGP 1381
+E+ +EEG Q E E E EG++ E + +++EE E +E + + E P
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 1382 EGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSP------DGKGSQEDDPVQEEEAGRA 1435
E + + ++E+G +E ++ P GK PV EE G++
Sbjct: 235 EKA-KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV--EEKGKS 291
Query: 1436 SASAEPCPAEGTEEPTEPPSHLSETDPSASERQSG 1470
S P EE + P S + + S+ + G
Sbjct: 292 PVSKSP-----VEEKAKSPVPKSPVEEAKSKAEVG 321
Score = 51.6 bits (122), Expect = 9e-06
Identities = 66/250 (26%), Positives = 107/250 (42%), Gaps = 39/250 (15%)
Query: 1275 EAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLE--------ETK 1326
E E+ E+ ++ E+LA + +E+ + E KE E E +EE + E K
Sbjct: 87 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE-EEPEAEEEEVAAKKSPVKATAPEVK 145
Query: 1327 TEEGLQEEGVQLEETKETEGEGQQEEE-AQLEEIEETG----GEGLQEEGVQLEEVKEGP 1381
EEG +EE +E + E ++E+E A+ ++ EE G G +EEG Q E E
Sbjct: 146 EEEGEKEE-------EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE 198
Query: 1382 EGGLQGEALEEGLKEEGLPEEGS-------VHGQELSEASSPDGKGSQED---DPVQE-- 1429
G + EA EE EE E + ++ +A SP K E+ PV +
Sbjct: 199 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP 258
Query: 1430 -EEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQ 1488
EE G++ P P EE + P S + S S +E + P + + +
Sbjct: 259 VEEKGKS-----PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEE 313
Query: 1489 EHTQAQPTQG 1498
++A+ +G
Sbjct: 314 AKSKAEVGKG 323
Score = 50.8 bits (120), Expect = 2e-05
Identities = 54/217 (24%), Positives = 90/217 (41%), Gaps = 24/217 (11%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E+ E E S E L T + V ++E K+ E +E+ + E + E +
Sbjct: 78 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKK----EAAEEKEEEPEAEEEEVAAK 133
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
+ V+ + E EG++EEE EE EE ++EG + ++ + EGG + E E
Sbjct: 134 KSPVKATAPEVKEEEGEKEEEEGQEEEEE------EDEGAKSDQAE---EGGSEKEGSSE 184
Query: 1393 GLKEEGLPEEGSVHGQ-ELSEASSPDGKGSQE--------DDPVQEEEAGRASASAEPCP 1443
KEEG EEG + E EA + + K +E ++ V + + + + P P
Sbjct: 185 --KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVP 242
Query: 1444 AEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKP 1480
EE + P S + S +E + P
Sbjct: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 279
Score = 48.5 bits (114), Expect = 8e-05
Identities = 54/201 (26%), Positives = 83/201 (41%), Gaps = 27/201 (13%)
Query: 1258 FPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQE 1317
F TF + T+ S+ Q+ +L E +EETK E ++E
Sbjct: 36 FSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEE 95
Query: 1318 EAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEE--------EAQLEEIEETGGEGLQE 1369
+ E + ++EE + E KE E E ++EE +A E++E GE +E
Sbjct: 96 ALTAITE-ELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 154
Query: 1370 EGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQE 1429
EG +E +E + G + + EEG G +EGS +E G QE+ +
Sbjct: 155 EG---QEEEEEEDEGAKSDQAEEG----GSEKEGSSEKEE----------GEQEEGETEA 197
Query: 1430 EEAG-RASASAEPCPAEGTEE 1449
E G A A E E +EE
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEE 218
Score = 45.4 bits (106), Expect = 7e-04
Identities = 49/173 (28%), Positives = 79/173 (45%), Gaps = 23/173 (13%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
+ +AE EQ+ E + E +E+V+ +E K E + E+ EE E
Sbjct: 315 KSKAEVGKGEQKEEEEKE-VKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTI 373
Query: 1333 EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEE 1392
+ V++ KET+ EG+ + Q +E E+ GGEG EE EG + G +G
Sbjct: 374 TKSVKVHLEKETKEEGKPLQ--QEKEKEKAGGEGGSEE--------EGSDKGAKGS---- 419
Query: 1393 GLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAE 1445
++E + G V G+E E + + KGS +EEE G + + PA+
Sbjct: 420 --RKEDIAVNGEVEGKEEVEQETKE-KGSG-----REEEKGVVTNGLDLSPAD 464
Score = 40.8 bits (94), Expect = 0.016
Identities = 45/224 (20%), Positives = 97/224 (43%), Gaps = 13/224 (5%)
Query: 1294 ENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEE 1353
++ V+E+ + K E +G + E K + + + V+ ++K G+G+Q+EE
Sbjct: 269 KSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEE 328
Query: 1354 AQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQ---EL 1410
+ +E++E E ++E+ +E P+ + + E +KEE + E ++ L
Sbjct: 329 EE-KEVKEAPKE------EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHL 381
Query: 1411 SEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTE-EPTEPPSHLSETDPSASERQS 1469
+ + +GK Q++ ++E+AG S E +G + E + E + Q
Sbjct: 382 EKETKEEGKPLQQEK--EKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQE 439
Query: 1470 GSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALD 1513
+ G E+ G G + + A +G + V + ++
Sbjct: 440 TKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE 483
Score = 35.4 bits (80), Expect = 0.68
Identities = 60/258 (23%), Positives = 99/258 (38%), Gaps = 30/258 (11%)
Query: 1668 SPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAE 1727
SP+ KA + P++EA ++ + ++ E + E E AP + + + E
Sbjct: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKE-APKEEKVEKKEEKPKDVPE 354
Query: 1728 GGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSEL 1787
+ V E S +++ +K+ K EG + QE+E + AG E
Sbjct: 355 KKKAESPVKEEAVAEVVTITKSVKVHLEKETK---EEGKPLQQEKE------KEKAGGE- 404
Query: 1788 GEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAE-GEAQP 1846
G +E+EG + G +GS ED G+ +G E +E E G +
Sbjct: 405 GGSEEEG------SDKGAKGSRKEDIAVN----------GEVEGKEEVEQETKEKGSGRE 448
Query: 1847 ESEGVEAPEAE-GDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E +GV + A E +G + E + V E + E D T V +
Sbjct: 449 EEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVE-KITSEGGDGATKYITKSVTVTQKV 507
Query: 1906 AEAPEAEKEAQPETESVE 1923
E E +E T+ VE
Sbjct: 508 EEHEETFEEKLVSTKKVE 525
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 106 bits (265), Expect = 2e-22
Identities = 130/590 (22%), Positives = 230/590 (38%), Gaps = 84/590 (14%)
Query: 1731 GPGLSQGPGVDEGEDG------------EGSQRLNRDKDPKL---GEAEGDAMAQEREGK 1775
G G+ +G G+ + D +G ++ D D K GE M+++ +GK
Sbjct: 4677 GGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGK 4736
Query: 1776 THNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAA------AGGDQDPGQS 1829
H+ GE E++ E + GG H +L GE A GD D +
Sbjct: 4737 MHD---------GELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEED 4787
Query: 1830 DGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESED 1889
+ E + E E + A + D+ + + + + E EAE + + ED
Sbjct: 4788 EEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGED 4847
Query: 1890 VETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA-----LETE----GEDEPESEGAE- 1939
+ + E+E + +E PE E+++ L++E GED EG E
Sbjct: 4848 KINEQIDERDYDENE-VDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEE 4906
Query: 1940 -----AQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQ 1994
++ EEA EAE + + E++ ESQ +E + SED +A E E + G
Sbjct: 4907 NPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKA---EGEEEMDTGADD 4963
Query: 1995 PESEDVEAPEAEGEMQE---AEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
+ + + PE E Q+ E++ + + +G E P +G + QE E + PE
Sbjct: 4964 QDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPE 5023
Query: 2052 S-----------DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGE-----AQ 2095
+ GVE + + + A ++ +G+ S DA +AEG AQ
Sbjct: 5024 ALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQ 5083
Query: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGE-----------AQPESEGIEAPEAEGEAQPE 2144
S+ + +K + + G+ +S + P + +AQ E
Sbjct: 5084 LASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVE 5143
Query: 2145 SEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGE----AQPESEGIEAPE 2200
+G +++ + E++ + G + E E E E E +A +
Sbjct: 5144 DADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAAD 5203
Query: 2201 AEGEAQPELE-GVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEK 2249
E E++ G AP +E + E + V+T E + ++ ET+ EK
Sbjct: 5204 VEQLKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETENEK 5253
Score = 98.2 bits (243), Expect = 9e-20
Identities = 140/590 (23%), Positives = 234/590 (39%), Gaps = 80/590 (13%)
Query: 1791 EQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEA----PEAEGEAQP 1846
+ GEG +E + G G G + ++ + G+++ + +G E P+++ + +
Sbjct: 4663 DSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKG 4722
Query: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEG-EAQPESEDVETPEAEWEVQPESEG 1905
E +E E + D + +GE + + ED E ++EG + D+ EA+ E
Sbjct: 4723 EDNAIEMSE-DFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEAD----KLDER 4777
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESE-GAEAQEAEEAAQEAEGQTQPESEVIESQ 1964
+ E+E + E ++ G DE +SE A+ + + Q + E E
Sbjct: 4778 LWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEA 4837
Query: 1965 EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVE 2024
EA++ Q E + E ++ E E E P + E ++ E E P+ ++
Sbjct: 4838 EADDGGQGEDKINEQID---ERDYDENEVDPYHGNQE------KVPEPEALDLPDDLNLD 4888
Query: 2025 AQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESED 2084
++ K+ GE+ EGE E + +E E EEA G E GE +
Sbjct: 4889 SEDKNGGEDTDNEEGE----------EENPLEIKEKPEEA----GHEAEERGETETD--- 4931
Query: 2085 VDAQEAEGEAQPESEGVEAP-EAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQP 2143
Q ES+ + P E E KAEG E +T + Q + + + PE E Q
Sbjct: 4932 ----------QNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQ-DGDAAQHPEEHSEEQQ 4980
Query: 2144 ES---EGVEAQDAEGEAQPESEGIEAQEAE--EEAQPELEGVEAPEAEGEAQPESEGIEA 2198
+S + EA + GE P +G + QE E E++ E + EA E + A G+E
Sbjct: 4981 QSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVE- 5039
Query: 2199 PEAEGEAQPELEGVEAPEAEEEAQPEPEG-VETPEAEGE---------AQPESEGETQGE 2248
+ EL G APE E+ + G + +AEG +Q + TQ
Sbjct: 5040 -NMQNTQAMELAGA-APEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSF 5097
Query: 2249 KKGSPQV----SLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRAS 2304
K+ Q S+GD +E + V D S P Q+P +Q + +
Sbjct: 5098 KRKPGQADNERSMGD-HNERVHKRLRTVDTD------SHAEQGPAQQPQAQVEDADAFEH 5150
Query: 2305 SWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEE 2354
D++ V + AK +G E + + T EQEE
Sbjct: 5151 IKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMD--TEEQEE 5198
Score = 76.6 bits (187), Expect = 3e-13
Identities = 103/460 (22%), Positives = 181/460 (39%), Gaps = 63/460 (13%)
Query: 1752 LNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELG-EAEQEGEGISERGETGGQGSGH 1810
LN D + K G + D E E E E G EAE+ GE +++ E+
Sbjct: 4885 LNLDSEDKNGGEDTDNEEGEEENPLEIKEKP--EEAGHEAEERGETETDQNESQSPQEPE 4942
Query: 1811 EDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPE 1870
E + + A G ++ +D +G A E ++ + + VE E + +A E GE P
Sbjct: 4943 EGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVE--EKDKEADEEGGENGPA 5000
Query: 1871 SEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEAL----- 1925
+ + E E E ED +T E E E A + E T+++E
Sbjct: 5001 DQGFQPQEEE-----EREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPE 5055
Query: 1926 ETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL----- 1980
+ +G++E S A+A +AE Q + ++ ++ + ++++ ++
Sbjct: 5056 KEQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNE 5115
Query: 1981 EVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE 2040
V + + ++ E + P+A+ E +A E + SD +AQ + Q+ +
Sbjct: 5116 RVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQ---Q 5172
Query: 2041 TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAE----GEAQP 2096
+ K G ++E +E E + + E + ++ DV+ + E G P
Sbjct: 5173 SAKDSG-------------KDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAP 5219
Query: 2097 ESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEA--------------Q 2142
G + E E + K E + P T+ +A E+E E PE E+ Q
Sbjct: 5220 --LGFDEMEVEIQTVKTEEDQDPRTD-KAHKETEN-EKPERSRESTIHTAHQFLMDTIFQ 5275
Query: 2143 PESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
P + V E E Q +E + E PE E V A
Sbjct: 5276 PFLKDVNELRQELERQ-----LEMWQPRESGNPEEEKVAA 5310
Score = 74.3 bits (181), Expect = 1e-12
Identities = 93/386 (24%), Positives = 156/386 (40%), Gaps = 48/386 (12%)
Query: 1695 RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNR 1754
+++ E EA E G+T TD +++ Q E +GP D+ +GE
Sbjct: 4912 KEKPEEAGHEAEE--RGETETDQNESQSPQEPE--------EGPSEDDKAEGE------E 4955
Query: 1755 DKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNL 1814
+ D + +GDA AQ E + + S + EA++EG GE G G +
Sbjct: 4956 EMDTGADDQDGDA-AQHPEEHSEEQQQSVEEKDKEADEEG------GENGPADQGFQPQ- 5007
Query: 1815 QGEAAAGGDQDPGQSDGAEGI-EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESED 1873
+++ SD E + EA E + A GVE + A E G A PE E
Sbjct: 5008 -------EEEEREDSDTEEQVPEALERKEHASCGQTGVENMQ-NTQAMELAG-AAPEKE- 5057
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+ E G ++ E E+ + Q S+ + + ++ +E
Sbjct: 5058 -QGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNER 5116
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ + + A++ Q QP+++V E +A E + S+ +A +V ++E + A
Sbjct: 5117 VHKRLRTVDTDSHAEQGPAQ-QPQAQV-EDADAFEHIKQGSDAYDAQTYDVASKEQQQSA 5174
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSE---------GEEAQEVEGETQKT 2044
+ +D E E E + + EE+ + ++ VE E G + EVE +T KT
Sbjct: 5175 KDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVKT 5234
Query: 2045 EGDAQPESDGVEAPEAEEEAQEAEGE 2070
E D P +D E E E E E
Sbjct: 5235 EEDQDPRTDKAH-KETENEKPERSRE 5259
Score = 52.4 bits (124), Expect = 5e-06
Identities = 72/293 (24%), Positives = 119/293 (40%), Gaps = 54/293 (18%)
Query: 1271 TNEDEAERDSEEQRASSNLEQ--LAENTVQEEVQLEETKE-------GTEGEGLQEEAVQ 1321
+N+D++++D +E++ + + E+ + E++ + E G + + + EA+
Sbjct: 4821 SNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALD 4880
Query: 1322 L--------------EETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGL 1367
L E+T EEG +E ++++E E G + EE ET E
Sbjct: 4881 LPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGH-------EAEERGET--ETD 4931
Query: 1368 QEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPV 1427
Q E +E +EGP + E EE + G ++ Q E S + +E D
Sbjct: 4932 QNESQSPQEPEEGPSEDDKAEGEEE--MDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKE 4989
Query: 1428 QEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT-MM 1486
+EE G E PA+ +P E E + S +E Q LE G T +
Sbjct: 4990 ADEEGG------ENGPADQGFQPQEE----EEREDSDTEEQVPEALERKEHASCGQTGVE 5039
Query: 1487 GQEHTQAQPTQGAA---ERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLAS 1536
++TQA GAA E+ S A D + + E F+A LAS
Sbjct: 5040 NMQNTQAMELAGAAPEKEQGKEEHGSGAADANQ------AEGHESNFIAQLAS 5086
Score = 42.4 bits (98), Expect = 0.006
Identities = 53/251 (21%), Positives = 98/251 (39%), Gaps = 48/251 (19%)
Query: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ---- 1332
E+D E+ + S+++ +++ E +G +G EE + +E EG
Sbjct: 4708 EKDKEDPDSKSDIKG-----EDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKH 4762
Query: 1333 ------EEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386
EE +L+E + + +++EE + + EET G G+ EE +L + + G
Sbjct: 4763 MGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEET-GPGMDEEDSELVAKDDNLDSGNS 4821
Query: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
+ + K+E E EA + D G Q +D + E+ R E P G
Sbjct: 4822 NKDKSQQDKKE-----------EKEEAEADD--GGQGEDKINEQIDERDYDENEVDPYHG 4868
Query: 1447 TEEPTEPPSHL----------------SETDPSASERQSGSQLEPGLEKPPGATMMGQEH 1490
+E P L +TD E ++ +++ EKP A +E
Sbjct: 4869 NQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIK---EKPEEAGHEAEER 4925
Query: 1491 TQAQPTQGAAE 1501
+ + Q ++
Sbjct: 4926 GETETDQNESQ 4936
>gi|119220598 apolipoprotein B48 receptor [Homo sapiens]
Length = 1088
Score = 105 bits (263), Expect = 4e-22
Identities = 203/826 (24%), Positives = 297/826 (35%), Gaps = 146/826 (17%)
Query: 1688 DLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGE 1747
+ Q+ L+ RG +G PG + V+ G G G S G + + G
Sbjct: 62 EAQEDLEGLRGSQNEGAGRLRGPGDDRRHEVGSSAVEQT-WGWGDGSSHGSQAERQDSGA 120
Query: 1748 G-----------SQRLNRDKDPKLGEA---EGDAMAQEREGKTHNSETSAGSELGEAEQE 1793
G S L K K G + AQER+ ++H E + L EQE
Sbjct: 121 GETAKAARCQEPSAHLEARKKSKAGSGACQDRSGQAQERQ-ESHEQEVNREERLRSWEQE 179
Query: 1794 GEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEA 1853
E R G G E G+++G G P+A G+ + +GV
Sbjct: 180 EEEEEVRAREPGMARGAESEWTWH---------GETEGKAGAVGPKAAGDNREMEQGVRE 230
Query: 1854 PEAEGDAQEAEGEAQPESEDVEAPEAEGE-----------AQPES------EDVETPEAE 1896
+A G+ +E E + E+V E E A+PE E+ T
Sbjct: 231 ADA-GETEEPGAEGAGKGEEVVVVEKACESTRAWGTWGPGAEPEDWGILGREEARTTPGR 289
Query: 1897 WEVQPESEGAEA------PEAE-----KEAQPETESVEA-LETEGEDEPESEGAEAQEA- 1943
E + +G EA EAE +EA+ + EA + GE+ + G EA A
Sbjct: 290 EEARAILDGEEARTISGGEEAETASGGEEAETASGGEEAGTASGGEEAGIASGGEAGTAS 349
Query: 1944 --EEAAQEAEGQT------QPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQP 1995
EEA + G + E++++ ++ E A P +EA +V E EG+ +
Sbjct: 350 GGEEAGTASGGDEAWTTSGKEEADLLGVRQTEYGAVPGERLLEATG-KVWVLEEEGDEER 408
Query: 1996 ESEDVEAPEAEGEM--QEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESD 2053
E+E P+ + + EE A+ ++ G EA E E+ EG+ +A+ D
Sbjct: 409 EAEVSPFPKQPQVLGTERTEEAAESQTAGREAVGGQEAGES--FEGQVDLRGKEAEMRQD 466
Query: 2054 -GVEAPEAE-------EEAQEAEGEVQE--AEGEAHPESEDVDAQEAEGEAQPESE---- 2099
G+ A A EEAQE G ++ AE + E+E EA EA+PE E
Sbjct: 467 LGIRADRARMEELVQAEEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGE 526
Query: 2100 ------------GVE------------APEAEGEAQ----KAEGIEAPETEG------EA 2125
GVE PE G AQ + E EA E E
Sbjct: 527 ESEAAQTSCGLLGVEWGGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSK 586
Query: 2126 QPESEGIEA-PEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE----AEEEAQPELEGV 2180
+ + +EA P G +PE+ E + + E QE E+ + E G
Sbjct: 587 EEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGG 646
Query: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPELE---GVEAPEAEEEAQPEPEGVETPEAE--- 2234
+ AE E ESE E PEA GE + G E EA E +G +A
Sbjct: 647 QTLAAEAEGDRESELSEVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCP 706
Query: 2235 --GEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSP---GGD-TP 2288
GEA ET+ E+ + + S G +A P ED T + GGD P
Sbjct: 707 SLGEAYAR---ETEDEEAEADRTS-RRGWRLQAVAVGLPDREDAQTGSVAAGIMGGDVVP 762
Query: 2289 HQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESS 2348
H S G + G W + + G+ E R +
Sbjct: 763 HI---SAAGAGEALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEA 819
Query: 2349 TSEQEEAPLGSRTPEQGASEGYDLQEDQALGSLAPTEAVGRADGFG 2394
+E P G R + ++ D GS RA+G G
Sbjct: 820 FESREGGPWGGRVEAEESAGAEDSCGLDPAGS-----QTARAEGMG 860
Score = 92.4 bits (228), Expect = 5e-18
Identities = 152/595 (25%), Positives = 214/595 (35%), Gaps = 76/595 (12%)
Query: 1741 DEGEDGEGSQRLNRDKDPKLGEAEGDA-MAQEREGKTHNSETSAGSELGEAEQEGEGISE 1799
+E ++ GS R + P GEAEG A + E + T SE + G+
Sbjct: 483 EEAQEERGSSRDPVAELPSDGEAEGTADLEATPEARPEEELTGEESEAAQTSCGLLGVEW 542
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDG--------AEGIEAPEAEGEAQPESEGV 1851
G T G L G A Q + G A E E EA P G
Sbjct: 543 GGLTHSVTKGQGPELMGGAQTPTKQPEEREAGEVELMGVLALSKEEQERSLEAGPRHAGS 602
Query: 1852 ---EAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDV--ETPEAEWEVQPESEGA 1906
EA EA A E E + + A+GE + E E +T AE E ESE +
Sbjct: 603 VKPEASEAFPGAWENRTRKDMERGNTQEDAADGEQREEEETAGGQTLAAEAEGDRESELS 662
Query: 1907 EAPEA------EKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEV 1960
E PEA ++A TE EA +E ++ S GA+A + +T+ E
Sbjct: 663 EVPEAGGEGLTTQDAGCGTEEGEASVSENQELDGSTGADAGPCPSLGEAYARETEDEEAE 722
Query: 1961 IESQ-------EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEA-EGEMQEA 2012
+ +A P+ ED + V G+ P A EA EG + +
Sbjct: 723 ADRTSRRGWRLQAVAVGLPDREDAQTGSVAAGIMG--GDVVPHISAAGAGEALEGVLGQ- 779
Query: 2013 EEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQ 2072
G +++ K E + G+ EG A+ E G + E++E
Sbjct: 780 ---------GWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGG 830
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAP-EAEGEAQKAEGIEAPET---EGEAQPE 2128
E E +ED + G +EG+ A EA G +K +E E E + +
Sbjct: 831 RVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQRED 890
Query: 2129 SEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVE---APEA 2185
SEG G+ PE E DAEG EA+E E E+ + G E +A
Sbjct: 891 SEG-----RCGDYHPEGEAPRLLDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQPTHQA 945
Query: 2186 EGEAQPESEG-IEAPEAEGEA---------QPELEG-----------VEAPEAEEEAQPE 2224
EA PES G E EA G A + L G V + + +
Sbjct: 946 PAEAAPESVGEAETAEAMGSARGGAANSWSEAPLPGSLLDVSVPRSRVHLSRSSSQRRSR 1005
Query: 2225 PEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTP 2279
P TP E + +P + + E Q L Q EE E S + P P
Sbjct: 1006 PSFRRTPAWEQQEEPPAPNPPEEELSAPEQRPL---QLEEPLEPSPLRHDGTPVP 1057
Score = 90.9 bits (224), Expect = 1e-17
Identities = 209/883 (23%), Positives = 314/883 (35%), Gaps = 118/883 (13%)
Query: 1268 ACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGEGLQEEAVQLEETK 1326
AC +A+ E N E+ + QEE + E +E G + E ET+
Sbjct: 148 ACQDRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETE 207
Query: 1327 TEEGL-----------QEEGVQLEETKETE-----GEGQQEEEAQLEEIEE------TGG 1364
+ G E+GV+ + ETE G G+ EE +E+ E T G
Sbjct: 208 GKAGAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEEVVVVEKACESTRAWGTWG 267
Query: 1365 EGLQEE--GVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQ 1422
G + E G+ E G + A+ +G E ++ G E +E +S G +
Sbjct: 268 PGAEPEDWGILGREEARTTPGREEARAILDG------EEARTISGGEEAETASG---GEE 318
Query: 1423 EDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEP----GLE 1478
+ EEAG AS E A G E T + T E + S E G+
Sbjct: 319 AETASGGEEAGTASGGEEAGIASGGEAGTASGGEEAGTASGGDEAWTTSGKEEADLLGVR 378
Query: 1479 KPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVL-LKKTEKAFLAHLAS- 1536
+ + G+ +A E A + P VL ++TE+A + A
Sbjct: 379 QTEYGAVPGERLLEATGKVWVLEEEGDEEREAEVSPFPKQPQVLGTERTEEAAESQTAGR 438
Query: 1537 -AVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKREL------QKLQGRAGRMVLE 1589
AV A + L AE++QD+ R + EL Q+ +G + V E
Sbjct: 439 EAVGGQEAGESFEGQVDLRGKEAEMRQDLGIRADRARMEELVQAEEAQEERGSSRDPVAE 498
Query: 1590 PPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGE 1649
P + G +L A E T E+ A T+ G LG
Sbjct: 499 LPSDG--------------EAEGTADLEATPEAR---PEEELTGEESEAAQTSCGL-LGV 540
Query: 1650 EAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVA 1709
E G + V+ MG + P K Q +R+ GE E V
Sbjct: 541 EWGG---------LTHSVTKGQGPELMGGAQTPTK------QPEEREAGEV---ELMGVL 582
Query: 1710 PGKTHTDPTSTRTVQGAEGGLGPGLSQG-PGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM 1768
S G + P S+ PG E + +R N +D GE
Sbjct: 583 ALSKEEQERSLEAGPRHAGSVKPEASEAFPGAWENRTRKDMERGNTQEDAADGE------ 636
Query: 1769 AQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHED----NLQGEAAAGGDQ 1824
Q E +T +T A G+ E E +SE E GG+G +D +GEA+ +Q
Sbjct: 637 -QREEEETAGGQTLAAEAEGDRESE---LSEVPEAGGEGLTTQDAGCGTEEGEASVSENQ 692
Query: 1825 DPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQ-----EAEGEAQPESEDVEAPEA 1879
+ S GA+ P GEA E EA+ ++ +A P+ ED +
Sbjct: 693 ELDGSTGADAGPCPSL-GEAYARETEDEEAEADRTSRRGWRLQAVAVGLPDREDAQTGSV 751
Query: 1880 E-----GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPE 1934
G+ P EA V +G ++ E E+ A E + EG E E
Sbjct: 752 AAGIMGGDVVPHISAAGAGEALEGVL--GQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEE 809
Query: 1935 SEGAEAQ-EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
G +Q EA E+ + + E+E ES AE+ + + E E
Sbjct: 810 VTGRGSQVEAFESREGGPWGGRVEAE--ESAGAEDSCGLDPAGSQTARAEGMGAMVEAGG 867
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESD 2053
E + EA G E E + +S+G EGE + ++ E G + E+
Sbjct: 868 LLEKWTLLEEEAVGWQ---EREQREDSEGRCGDYHPEGEAPRLLDAEGLMVTGGRRAEAK 924
Query: 2054 GVEAPEAEEEAQEAEGEVQEAEGEAHPES-EDVDAQEAEGEAQ 2095
E E + E +A EA PES + + EA G A+
Sbjct: 925 ETEPESLEHVRGQEEQPTHQAPAEAAPESVGEAETAEAMGSAR 967
Score = 50.4 bits (119), Expect = 2e-05
Identities = 62/224 (27%), Positives = 88/224 (39%), Gaps = 33/224 (14%)
Query: 2054 GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKA 2113
G P E EAQ AE A G+ E+ ++ EG ++EG G+ ++
Sbjct: 31 GDAVPTVEREAQAAEELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDRRH 90
Query: 2114 E-GIEAPE-TEGEAQPESEGIEA------------------PEAEGEAQPESEGVE--AQ 2151
E G A E T G S G +A P A EA+ +S+ Q
Sbjct: 91 EVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGACQ 150
Query: 2152 DAEGEAQPESEGIEAQEAEE------EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEA 2205
D G+AQ E E + E E + E E V A E ESE E EG+A
Sbjct: 151 DRSGQAQERQESHEQEVNREERLRSWEQEEEEEEVRAREPGMARGAESEWTWHGETEGKA 210
Query: 2206 QPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEK 2249
G P+A + + +GV +A +P +EG +GE+
Sbjct: 211 -----GAVGPKAAGDNREMEQGVREADAGETEEPGAEGAGKGEE 249
Score = 41.2 bits (95), Expect = 0.012
Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 23/249 (9%)
Query: 1305 ETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGG 1364
E EG G+G + + G QE G++ +E G G Q E + E GG
Sbjct: 771 EALEGVLGQGWDSKEKEEAAAGEHAGGQEFGLEGSAEEEVTGRGSQVEAFESREGGPWGG 830
Query: 1365 EGLQEEGVQLEEVKEGPEGGLQ-------GEALEEG--LKEEGLPEEGSVHGQELSEASS 1415
EE E+ G Q G +E G L++ L EE +V QE +
Sbjct: 831 RVEAEESAGAEDSCGLDPAGSQTARAEGMGAMVEAGGLLEKWTLLEEEAVGWQEREQRED 890
Query: 1416 PDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEP 1475
+G+ D E EA R AEG + ET+P + E G + +P
Sbjct: 891 SEGRCG---DYHPEGEAPRL------LDAEGLMVTGGRRAEAKETEPESLEHVRGQEEQP 941
Query: 1476 GLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLA 1535
+ P A + G+A ++ + S A P+ S+L ++ HL+
Sbjct: 942 THQAPAEAAPESVGEAETAEAMGSARGGAANSWSEA----PLPGSLLDVSVPRS-RVHLS 996
Query: 1536 SAVAELRAR 1544
+ ++ R+R
Sbjct: 997 RSSSQRRSR 1005
Score = 37.4 bits (85), Expect = 0.18
Identities = 54/234 (23%), Positives = 91/234 (38%), Gaps = 31/234 (13%)
Query: 2139 GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEA 2198
G+A P E EAQ AE E + G + EEEAQ +LEG+ + EG + G +
Sbjct: 31 GDAVPTVER-EAQAAE-ELGVVAVGKTGKIVEEEAQEDLEGLRGSQNEGAGRLRGPGDDR 88
Query: 2199 PEAEGEAQPELE---GVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKK-GSPQ 2254
G + E G + + + + ET +A +P + E + + K GS
Sbjct: 89 RHEVGSSAVEQTWGWGDGSSHGSQAERQDSGAGETAKAARCQEPSAHLEARKKSKAGSGA 148
Query: 2255 VSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDS 2314
GQ++E ES H++ ++ R SW +++
Sbjct: 149 CQDRSGQAQERQES--------------------HEQEVNR----EERLRSWEQEEEEEE 184
Query: 2315 ENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASE 2368
G R +++ T E KA + P+++ + E G R + G +E
Sbjct: 185 VRAREPGMARGAESEWTWHGETEGKAGAVGPKAA-GDNREMEQGVREADAGETE 237
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1415
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1771
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 1947
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 1948 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 1982
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 1983 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2041 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2094 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2325
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2386 KLRVAEMSRAQARAEEDAQ 2404
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1411 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1399
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1400 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1573
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1574 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1623
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1624 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1681
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1631
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1632 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1688
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1862
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 1863 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 1911
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 1912 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 1965 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 2022 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2068
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2129 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2305 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1698
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1759 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 1910 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 2021
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 2022 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2076
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2077 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2188 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2359
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2360 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2414
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2464
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2584
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2641
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2642 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2674
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1156
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1157 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1217 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1268
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1447
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1448 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2258 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2371 ERQRQLEMSAEAERLK 2386
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1361 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1419
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1420 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1479
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1480 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1539
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1540 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1775
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 1951
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 1952 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 1986
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 1987 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2044
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2045 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2098 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2150
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2271 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2329
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2330 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2390 KLRVAEMSRAQARAEEDAQ 2408
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1355 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1414
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1415 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1472 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1529
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1708
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1403
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1404 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1519 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1577
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1578 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1627
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1628 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1685
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1686 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1635
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1636 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1692
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1693 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1866
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 1867 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 1915
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 1916 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1968
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 1969 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2025
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 2026 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2072
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2133 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2189 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2248
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2249 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2309 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2548 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2589
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1650 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1702
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1762
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1763 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1940
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 1941 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2000
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 2001 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2060
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1794 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1854 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 1914 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1970
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 1971 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 2025
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 2026 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2080
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2081 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2134
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2135 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2191
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2192 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2247
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2307
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2363
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2364 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2418
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2468
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2528
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2529 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2588
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2589 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2645
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2646 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2678
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1102 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1160
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1161 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1220
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1221 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1272
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1273 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1332
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1333 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1392
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1393 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1451
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1452 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1509 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2262 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2316
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2317 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2374
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2375 ERQRQLEMSAEAERLK 2390
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1415
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1416 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1475
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1476 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1535
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1771
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 1947
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 1948 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 1982
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 1983 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2040
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2041 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2094 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2146
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2267 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2325
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2326 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2386 KLRVAEMSRAQARAEEDAQ 2404
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1411 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1468 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1525
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1704
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1399
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1400 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1515 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1573
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1574 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1623
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1624 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1681
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1682 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1631
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1632 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1688
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1689 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1862
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 1863 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 1911
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 1912 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1964
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 1965 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2021
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 2022 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2068
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2129 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2244
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2245 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2305 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2544 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2585
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1646 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1698
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1758
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1759 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1996
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 1997 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2056
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1790 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 1910 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1966
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 2021
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 2022 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2076
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2077 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2130
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2131 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2187
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2188 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2243
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2303
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2359
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2360 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2414
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2464
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2524
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2525 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2584
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2641
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2642 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2674
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1098 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1156
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1157 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1216
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1217 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1268
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1269 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1329 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1388
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1389 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1447
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1448 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1505 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2258 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2312
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2313 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2370
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2371 ERQRQLEMSAEAERLK 2386
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1325 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1383
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1384 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1443
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1444 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1503
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1623
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1739
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1859
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 1860 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 1915
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 1916 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 1950
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 1951 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2008
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2009 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2062 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2114
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2235 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2293
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2294 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2354 KLRVAEMSRAQARAEEDAQ 2372
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1319 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1378
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1379 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1436 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1493
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1672
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1367
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1368 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1483 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1541
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1542 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1591
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1592 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1649
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1650 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1599
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1600 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1656
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1657 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1830
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 1831 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 1879
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 1880 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1932
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 1933 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1989
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 1990 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2036
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2097 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2153 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2212
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2213 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2273 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2392 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2451
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2452 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2512 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2553
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1614 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1666
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1726
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1727 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1904
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 1905 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1964
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 1965 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2024
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1758 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1818 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 1878 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1934
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 1935 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 1989
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 1990 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2044
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2045 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2098
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2099 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2155
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2156 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2211
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2271
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2327
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2328 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2382
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2432
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2492
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2493 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2552
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2553 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2609
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2610 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2642
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1066 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1124
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1125 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1184
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1185 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1236
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1237 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1296
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1297 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1356
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1357 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1415
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1416 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1473 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2226 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2280
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2281 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2338
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2339 ERQRQLEMSAEAERLK 2354
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1552
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1908
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 2084
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 2085 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 2119
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 2120 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2178 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2231 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2462
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2523 KLRVAEMSRAQARAEEDAQ 2541
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1488 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1547
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1548 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1605 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1662
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1841
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1536
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1537 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1652 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1710
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1711 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1760
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1761 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1818
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1819 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1768
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1769 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1825
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1826 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1880
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1999
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 2000 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 2048
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 2049 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 2101
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 2102 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 2159 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2205
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2266 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2322 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2381
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2442 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2561 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2620
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2621 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2681 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2722
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1783 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1835
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1895
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1896 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 2074 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1927 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1987 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 2047 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 2103
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 2104 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 2158
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 2159 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2213
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2214 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2268 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2325 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2380
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2440
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2496
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2497 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2551
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2601
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2662 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2721
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2722 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2778
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2779 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2811
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1235 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1293
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1294 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1353
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1354 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1405
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1465
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1466 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1525
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1526 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1584
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1585 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1642 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2395 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2449
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2450 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2508 ERQRQLEMSAEAERLK 2523
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1393
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1749
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 1925
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 1926 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 1960
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 1961 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2019 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2072 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2303
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2364 KLRVAEMSRAQARAEEDAQ 2382
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1388
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1389 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1445
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1446 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1503
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1682
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1683 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1377
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1378 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1551
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1552 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1601
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1602 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1659
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1660 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1609
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1610 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1666
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1667 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1721
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1840
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 1841 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 1889
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 1890 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1942
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 1943 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 2000 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2046
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2107 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2162
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2163 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2222
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2283 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2402 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2461
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2462 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2522 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2563
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1624 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1676
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1736
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1737 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 1915 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2091
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1768 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1828 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 1888 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1944
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 1999
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 2000 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2054
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2055 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2109 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2165
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2166 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2221
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2222 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2337
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2338 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2392
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2442
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2503 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2562
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2563 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2619
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2620 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2652
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1076 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1134
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1135 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1194
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1195 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1246
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1306
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1307 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1366
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1367 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1425
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1426 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1483 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2236 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2290
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2291 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2349 ERQRQLEMSAEAERLK 2364
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1401
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1402 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1461
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1462 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1521
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1522 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1641
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1757
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1877
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 1878 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 1933
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 1934 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 1968
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 1969 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2026
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2027 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2080 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2132
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2253 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2311
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2312 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2372 KLRVAEMSRAQARAEEDAQ 2390
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1337 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1396
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1397 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1453
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1454 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1511
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1690
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1691 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1385
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1386 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1501 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1559
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1560 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1609
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1610 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1667
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1668 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1617
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1618 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1674
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1675 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1729
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1848
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 1849 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 1897
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 1898 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1950
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 1951 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2007
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 2008 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2054
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2115 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2170
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2171 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2230
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2231 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2291 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2409
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2410 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2469
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2470 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2530 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2571
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1632 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1684
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1744
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1745 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1922
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 1923 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1982
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 1983 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2042
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2043 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2099
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1776 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1836 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 1896 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1952
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 1953 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 2007
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 2008 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2062
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2063 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2116
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2117 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2173
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2174 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2229
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2230 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2289
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2345
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2346 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2400
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2450
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2510
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2511 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2570
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2571 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2627
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2628 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2660
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1084 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1142
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1143 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1202
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1203 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1254
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1255 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1314
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1315 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1374
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1375 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1433
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1434 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1491 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2244 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2298
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2299 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2356
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2357 ERQRQLEMSAEAERLK 2372
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 100 bits (250), Expect = 1e-20
Identities = 243/1099 (22%), Positives = 412/1099 (37%), Gaps = 156/1099 (14%)
Query: 1274 DEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTE----- 1328
+E ER +E + A QLAE Q + Q E + + + +QEE V+ EE +
Sbjct: 1384 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1442
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKE---GPEGGL 1385
+QEE QL ++ E E + + + E E ++ +QLE + G EG L
Sbjct: 1443 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1502
Query: 1386 QG--------EALEEGLKEEGLPEEGSVHGQ---------ELSEASSPDGKGSQEDDP-- 1426
Q EA + +EE V + EL+ + + ++E
Sbjct: 1503 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1562
Query: 1427 -------VQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETD---PSASERQSGSQLEPG 1476
+Q EEA R AE A + E +E + AS + +QLE
Sbjct: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622
Query: 1477 LEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVS----VLLKKTEKAFLA 1532
L++ A +E + + Q A + L+ + + + L+ E A
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1682
Query: 1533 HLASAVAE---------LRARWGLQDNDLLDQMAAELQQDVAQRLQDST-------KREL 1576
LA A AE R R ++ + + AE + + ++L + T ++EL
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742
Query: 1577 QKL-----QGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSF 1631
+L QG R +LE L E TQ+R+ L + A E L S
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SK 1798
Query: 1632 TLEDEPALSTALGSQLGEEAEGEEFCPC--EACVRKKVSPMSPKATMGATRGPIKEAFDL 1689
+E + ST+ S+ EAE F EA + ++ + + A ++ +
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 1690 QQILQRKR---GEHTDGEA-AEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGED 1745
+++L K GE T + AE+A + + R + E L + + +
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1918
Query: 1746 GEGSQRLNRDKDPKLGEAEG---DAMAQEREGKTHNSETSAGSE---LGEAEQEGEGISE 1799
E +L + D +L +G D + Q R+ + A E G+AE E E
Sbjct: 1919 EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE---- 1974
Query: 1800 RGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD 1859
G S ED L+ + E E E Q + A E E
Sbjct: 1975 ---LGRIRSNAEDTLRSK------------------EQAELEAARQRQL----AAEEERR 2009
Query: 1860 AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPET 1919
+EAE Q E EA + + E+VE +A+ E E+ ++ Q
Sbjct: 2010 RREAEERVQKSLAAEE--EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2067
Query: 1920 ESVEA-LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEA-QPESEDV 1977
E+ + L+ E E A A ++ QE + Q E V++ E EA + +E+
Sbjct: 2068 EAAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK----SEGEE 2033
E V+ E + A+ Q E EAE Q AEE+AQ + A K +E E
Sbjct: 2121 EEARVQAEREAAQSRRQVE-------EAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2173
Query: 2034 AQEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGE-----VQEAEGEAHPESED 2084
A+ + E QK DA+ E A + + + E E +Q E + D
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 2085 VDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGI---EAPEAEGEA 2141
+ Q + EA + E E + + + E + + + E+ + + +
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 2142 QPESE------------GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEA 2189
Q E+E V AQ+A Q E + Q A E + E ++A +
Sbjct: 2294 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-EKMQAVQEATRL 2352
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVE-TPEAEGEAQPESEGETQGE 2248
+ E+E ++ + + Q + + ++ E +G + T EAE + Q E E +
Sbjct: 2353 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 2249 KKGSPQVSLGDGQSEEASE 2267
K ++S ++EE ++
Sbjct: 2413 KLRVAEMSRAQARAEEDAQ 2431
Score = 85.1 bits (209), Expect = 7e-16
Identities = 105/391 (26%), Positives = 175/391 (44%), Gaps = 32/391 (8%)
Query: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEE 1969
AE++ E E + +E E + + A AQ +A +EA E Q + + EV+ +EA +
Sbjct: 1378 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1437
Query: 1970 AQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPK- 2028
AQ + ++ E++ Q +E E Q ++ EA AE EEE + +EA +
Sbjct: 1438 AQQQKRSIQE-ELQQLRQSSEAEIQAKARQAEA--AERSRLRIEEEIRVVRLQLEATERQ 1494
Query: 2029 ---SEGE----EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA---EGEA 2078
+EGE A+ E E QK + AQ E++ + +E ++ + EV+ A + EA
Sbjct: 1495 RGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDESQRKRQAEVELASRVKAEA 1552
Query: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIE-APET-EGEAQPESEGIEAPE 2136
E A +A E + ++E E + E ++A ++ A ET + A+ E + A
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 2137 AEGEAQPESEGVEAQDAEGEAQPESE-----GIEAQEAEEEAQPELEGVEAPEAEG---E 2188
AE AQ E E A + + E+E EA+ A EEA+ ELE + E
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 2189 AQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGV---ETPEAEGEAQPE-SEGE 2244
Q E + A+ EA+ + E E EA + E + V E E E E Q + +EG
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAER-EARRRGKAEEQAVRQRELAEQELEKQRQLAEGT 1731
Query: 2245 TQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Q ++ ++E+ + + E+
Sbjct: 1732 AQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762
Score = 82.0 bits (201), Expect = 6e-15
Identities = 104/393 (26%), Positives = 170/393 (43%), Gaps = 42/393 (10%)
Query: 1874 VEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEP 1933
+E E E Q E E E ++ + + AEA A+ +AQ E E+ E + E
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-HAQAKAQAEREAKELQQRMQE--- 1426
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIES--QEAEEEAQPESEDVEALE---VEVETQE 1988
E EEAA +A+ Q + E ++ Q +E E Q ++ EA E + +E +
Sbjct: 1427 -----EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481
Query: 1989 AEGEAQPESEDVEAPEAEGEMQ-------EAE---EEAQPESDGVEAQPKSEGEEAQEVE 2038
Q E+ + + AEGE+Q EAE +AQ E++ + Q + E + ++ E
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541
Query: 2039 GE-TQKTEGDAQPESDGVEAPEAEEE----AQEAEGEVQEAEGEAHPESEDVDAQEAEGE 2093
E + + +A+ + A +A EE A+EAE +++AE E V + A+
Sbjct: 1542 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-RARQVQVALETAQRS 1600
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDA 2153
A+ E + A AE AQ E Q E + E E + + + EA+ A
Sbjct: 1601 AEAELQSKRASFAEKTAQ---------LERSLQEEHVAVAQLREEAERRAQQQ-AEAERA 1650
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVE 2213
EA+ E E + +A E + L+ E + + AQ E+E + EAE EA+ + E
Sbjct: 1651 REEAERELERWQL-KANEALRLRLQAEEVAQQKSLAQAEAEK-QKEEAEREARRRGKAEE 1708
Query: 2214 APEAEEEAQPEPEGVETPEAEGEAQPESEGETQ 2246
+ E + + AEG AQ E +
Sbjct: 1709 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Score = 82.0 bits (201), Expect = 6e-15
Identities = 220/1062 (20%), Positives = 415/1062 (39%), Gaps = 153/1062 (14%)
Query: 1262 LNARACACATNEDEAERDSEEQR-ASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAV 1320
L ++ + A + ER +E+ A + L + AE Q++ + E +E E E +
Sbjct: 1605 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE------L 1658
Query: 1321 QLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE-ETGGEGLQEEGVQLEEVKE 1379
+ + K E L+ +Q EE + + Q E E Q EE E E G EE Q +E
Sbjct: 1659 ERWQLKANEALRLR-LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE--QAVRQRE 1715
Query: 1380 GPEGGLQGEA-LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE------EA 1432
E L+ + L EG ++ L E QEL + +G Q+ ++EE EA
Sbjct: 1716 LAEQELEKQRQLAEGTAQQRLAAE-----QELIRLRAETEQGEQQRQLLEEELARLQREA 1770
Query: 1433 GRASASAEPCPAEGTEEPTE------PPSHLSETDPSASER----------------QSG 1470
A+ + AE + E + E S SE+ +
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 1471 SQLEPGLEKPPGATMMGQEHTQAQPTQGA---AERSSSVACSAALDCDPIWVSVLLKKTE 1527
++L E+ + +E Q + AE+ +++ + L + +++ K+ E
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE-IALKEKEAE 1889
Query: 1528 KAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMV 1587
L LA A R R L++ AA+ + D+ +RL K +L+ + G
Sbjct: 1890 NERLRRLAEDEAFQRRR--------LEEQAAQHKADIEERLAQLRKASDSELERQKG--- 1938
Query: 1588 LEPPREALTGELLLQTQQRRHRLRGLRN-----LSAFSERTLGLGPLSFTLED------E 1636
L + L Q +Q + L+ + +E L LG + ED +
Sbjct: 1939 -------LVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQ 1991
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQ-- 1694
L A QL E E EA R + S + + + ++E L+ ++
Sbjct: 1992 AELEAARQRQLAAEEERRRR---EAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2048
Query: 1695 ---RKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQR 1751
R+R E ++A + + +Q E + Q ++ E Q
Sbjct: 2049 RRLRERAEQESARQLQLA------QEAAQKRLQAEEKAHAFAVQQ-------KEQELQQT 2095
Query: 1752 LNRDK---DPKLGEAEGDAMAQER--EGKTHNSETSAGS--ELGEAEQEGEGISERGETG 1804
L +++ D GEAE A E E + +A S ++ EAE+ + E+ +
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155
Query: 1805 GQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPE-SEGVEAPEAEG 1858
Q + L+ EA +Q+ + AE +A +AE E + +E +A+
Sbjct: 2156 AQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2211
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPE--SEGAEAPEAEK-E 1914
+ + Q E D + + E Q ++E E +V+ E S + E K +
Sbjct: 2212 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK 2271
Query: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEE--AQP 1972
A+ E E+ + + ++ EA++ ++ A+EA + E ++ EE AQ
Sbjct: 2272 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Query: 1973 ES-------EDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ---PESDG 2022
+ E ++A++ E +AE E + +++ +A ++ E+ AQ E+ G
Sbjct: 2332 RALAEKMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390
Query: 2023 VEAQPKSEGEEAQEVEGETQK--------TEGDAQPESDGVEAPEAEEEAQEA--EGEVQ 2072
+ ++E + E+ E ++ + A+ E D + EE E E+
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2450
Query: 2073 EAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE--AQKAEGIEAPETEGEAQPESE 2130
E ++ ++ Q+++ +A+ E + E E E Q+A+ ++ E + + +
Sbjct: 2451 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2510
Query: 2131 GIEAPEA-------EGEAQPESEG-VEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEA 2182
++ +A E ++ + E +E + A+ E + E +AQ+ EE Q + + +E
Sbjct: 2511 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 2183 PEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
A E EAE + + E ++ E + Q E
Sbjct: 2571 ERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2612
Score = 78.6 bits (192), Expect = 7e-14
Identities = 149/657 (22%), Positives = 250/657 (38%), Gaps = 65/657 (9%)
Query: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGH-EDNLQGEAA 1819
G AEG+ A + ++ E EAE+ + + + Q ++ EA
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQE--EAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553
Query: 1820 AGGDQDPGQSDGAE-GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPE 1878
A ++ E ++A EAE + ++E A + + + A+ A+ E + A
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 1879 AEGEAQPESEDVETPEAEWEVQPESEG-----AEAPEAEKEAQPETESVEA-------LE 1926
AE AQ E E A +++ E+E AEA A +EA+ E E + L
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
+ E+ + + EAE+ +EAE + + + AEE+A + E E E+E +
Sbjct: 1673 LQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK------AEEQAVRQRELAEQ-ELEKQR 1725
Query: 1987 QEAEGEAQPE-SEDVEAPEAEGEMQEAEEEAQ---PESDGVEAQPKSEGEEAQEVEGETQ 2042
Q AEG AQ + + E E ++ E++ Q E ++ + + ++ QE+E E
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELA 1785
Query: 2043 KTEGDAQPESDGVEAPEAEEEAQE-AEGEVQEAEGEAHPESEDVD--------AQEAEGE 2093
K A+ E AEEE++ +E Q E EA E + A+EA+ +
Sbjct: 1786 KVR--AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843
Query: 2094 AQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESE-GIEAPEAEGE-----AQPES-- 2145
Q E AE E AE + A + E+E ++ EAE E A+ E+
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 2146 -EGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPE---- 2200
+E Q A+ +A E + ++A + +G+ Q E E +
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963
Query: 2201 -AEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGD 2259
A G+A+ ELE E+ E E A E + E + Q SL
Sbjct: 1964 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2023
Query: 2260 GQS---------EEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCW 2310
+ EE + V E R + + + +A + +
Sbjct: 2024 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2083
Query: 2311 ---QKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQ 2364
QK+ E L +S + G A R+A E+ + EA R E+
Sbjct: 2084 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2140
Score = 69.3 bits (168), Expect = 4e-11
Identities = 183/934 (19%), Positives = 355/934 (38%), Gaps = 81/934 (8%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQ 1332
E EA R E ++ L LAE ++ EE E + A +L L+
Sbjct: 1817 EAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876
Query: 1333 EEGVQLEETKETEGEG----QQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGE 1388
E + KE E E ++E Q +EE + + +L ++++ + L+ +
Sbjct: 1877 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936
Query: 1389 ALEEGLKEEGLPEEGSVHGQELSEASSPDG---------------KGSQEDDPVQEEEAG 1433
+GL E+ L + V + L+ +S + + + ED +E+A
Sbjct: 1937 ---KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAE 1993
Query: 1434 RASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
+A AE E + ++ A+E ++ Q + LE+ + + +A
Sbjct: 1994 LEAARQRQLAAEEERRRREAEERVQKS--LAAEEEAARQRKAALEE---VERLKAKVEEA 2048
Query: 1494 QPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLL 1553
+ + AE+ S+ A + L+ EKA + EL+ Q+ +L
Sbjct: 2049 RRLRERAEQESARQLQLAQEA----AQKRLQAEEKAHAFAVQQKEQELQQTLQ-QEQSVL 2103
Query: 1554 DQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGL 1613
DQ+ E + A+R + E ++ + +A R + R+ E L Q+ + + + R
Sbjct: 2104 DQLRGEAE--AARRAAE----EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2157
Query: 1614 RNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCP-CEACVRKKVSPMSP 1672
+A R + + E A AL + +AE E+ E +R+K
Sbjct: 2158 AQAAAEKLRKEAEQEAARRAQAEQA---ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2214
Query: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPT--STRTVQGAEGGL 1730
T+ R ++E D Q+ L + + EA E A ++ + S R L
Sbjct: 2215 LTTL---RLQLEET-DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKL 2270
Query: 1731 GPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAM-----AQEREGKTHNSETSAGS 1785
+ D + +QR +++ K+ + +A AQE +E
Sbjct: 2271 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ 2330
Query: 1786 ELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ 1845
+ AE+ + + + + + LQ + +Q + E + AE
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE---- 2386
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
E++G + ++ E A+ E + E ED + + Q E G
Sbjct: 2387 -ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ----RFRKQAEEIG 2441
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
+ E Q + V+ LE + + +A+ EA E E + + + Q+
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDH----DAERLREAIAELEREKE------KLQQ 2491
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAEEEAQPESDG 2022
+ Q +SE+++ ++ E QE + Q E + + E E ++A+ E + +
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2551
Query: 2023 VEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPES 2082
+AQ E ++ Q+ + E ++ A E EAEE + + E+Q+ E + +
Sbjct: 2552 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2611
Query: 2083 EDV--DAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
E + + Q + Q E A A E A + A +T + + ++ P AE E
Sbjct: 2612 ELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGR---DALDGPAAEAE 2668
Query: 2141 AQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
+ +G+ + + Q E+ + A+E + AQ
Sbjct: 2669 PEHSFDGLRRKVSAQRLQ-EAGILSAEELQRLAQ 2701
Score = 55.8 bits (133), Expect = 5e-07
Identities = 102/452 (22%), Positives = 177/452 (39%), Gaps = 39/452 (8%)
Query: 1829 SDGAEGI----EAPEAEGEAQPES-EGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEA 1883
+ GAE + E E +A P + +EA +A A+ EAQ + D E G A
Sbjct: 1125 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-A 1183
Query: 1884 QPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGE----------DEP 1933
Q E ++ E +V+ E + + Q + + E E +
Sbjct: 1184 QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESA 1243
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
+ GA Q+A ++ + +S+ + Q +E+A E E+E ++ E E
Sbjct: 1244 DPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLE-------EIERHGEKVE-EC 1295
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ-PK----SEGEEAQEVEGETQKTEGDA 2048
Q ++ + E+Q +AQ E A+ PK SE + V+ T +E
Sbjct: 1296 QRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1355
Query: 2049 QPESDGVEAPEA----EEEAQEAEGE-VQEAEGEAHPESE-DVDAQEAEGEAQPESEGVE 2102
E EEE + AE + +E E A E+ + Q AE AQ +++
Sbjct: 1356 LTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAER 1415
Query: 2103 APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
+ + + E + E +AQ + I+ + E+E ++A+ + EA S
Sbjct: 1416 EAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE-IQAKARQAEAAERSR 1474
Query: 2163 GIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQ 2222
+ +E + +LE E G A+ E + + A E EAQ EA + Q
Sbjct: 1475 -LRIEEEIRVVRLQLEATE--RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531
Query: 2223 PEPEGVETPEAEGEAQPESEGETQGEKKGSPQ 2254
E + E E ++ ++E E EK+ + Q
Sbjct: 1532 DESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Score = 33.1 bits (74), Expect = 3.4
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 13/136 (9%)
Query: 1249 DLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAE------NTVQEEVQ 1302
D +N Q+ FL A +EA R S + ++ L QLAE + E++
Sbjct: 2285 DKDNTQR-----FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKML 2339
Query: 1303 LEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET 1362
E+ + E L+ EA L++ K E QE+ +L+E KE + EE + E
Sbjct: 2340 KEKMQAVQEATRLKAEAELLQQQK--ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2397
Query: 1363 GGEGLQEEGVQLEEVK 1378
+ E + E +K
Sbjct: 2398 ERQRQLEMSAEAERLK 2413
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 100 bits (249), Expect = 2e-20
Identities = 129/560 (23%), Positives = 231/560 (41%), Gaps = 59/560 (10%)
Query: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEA---QPESEDVETPEAEWEVQPESEGAEAPEA 1911
E + E E ++ E V+A AE +A +P++ +T + E +V+PE + E +
Sbjct: 597 ETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKP 656
Query: 1912 EKEAQPETESVEALETEGEDEPE-----SEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966
+KE + + + E + E + + +E +E +E + +T P+ EV + +
Sbjct: 657 KKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPK-EVKKEVKK 715
Query: 1967 EEEAQPESEDVE-ALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEE--------AQ 2017
EE+ + + E+ E E++ ++A+ + P SE + + ++ + EE +
Sbjct: 716 EEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGK 775
Query: 2018 PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGE 2077
P+ G K EG+ A+ V A + A + EAE + + +
Sbjct: 776 PKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPED 835
Query: 2078 AHPESEDVDAQEAE--GEAQPESEGVEAPEAEGEAQKAEGI----EAPETEGEAQPESEG 2131
+ E++ A+E + + +P+ E +E E E + E E T+G A+ EG
Sbjct: 836 LTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEG 895
Query: 2132 IEAPEAEGEAQ---PESEGVEAQDAEGEAQPESEGIEAQEAEE----EAQPELEGVEAPE 2184
I E EGE + E E VE Q + + E EG +E+ E E + E E E PE
Sbjct: 896 ITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPE 955
Query: 2185 AEGE----------AQPESEGIEAPEAEGEAQPELEGVEAPE--AEEEAQPEPEGVETPE 2232
+GE + E E EA+ + + E V + + AEE+ E E +
Sbjct: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQ 1015
Query: 2233 AEGEAQPESEGETQGEKKGSPQVSLGD----GQSEEASESSSPVPE--DRPTPPPSPGGD 2286
+E EA E + E E++ P+ + ++A+E+ + TP G
Sbjct: 1016 SEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQ 1075
Query: 2287 TPHQRPGSQTGPSSSRASSWGNCWQKDSENDH--------VLGDTRSP-DAKSTGTPHAE 2337
+P + P S + S D EN G T+S + S TP E
Sbjct: 1076 SPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMDE 1135
Query: 2338 RKATR-MYPESSTSEQEEAP 2356
R + + + +E+ E+P
Sbjct: 1136 MSTPRDVMSDETNNEETESP 1155
Score = 97.8 bits (242), Expect = 1e-19
Identities = 150/629 (23%), Positives = 244/629 (38%), Gaps = 100/629 (15%)
Query: 1843 EAQPESEGVEAPEAEGDAQEAEGEAQ-PESEDVEAPEAEGEAQPESEDVETPEAEWEVQ- 1900
E +P+ E + P+ + EA+ P + + P+ E + +S P+ + +++
Sbjct: 725 EKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
Query: 1901 --PESEGAEAPEAEKEAQPETESVEAL----------ETEGE----DEPESEGAEAQEAE 1944
E + AEA A T +V A E E E PE + +E +
Sbjct: 785 IKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELK 844
Query: 1945 EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPE 2004
+ +P+ E+IE +E +E +P VEA ++ E + +G A+ E + E
Sbjct: 845 AEEVDVTKDIKPQLELIEDEEKLKETEP----VEAYVIQKEREVTKGPAESPDEGITTTE 900
Query: 2005 AEGEMQEAEEEAQP-ESDGVEAQPKSEGEEAQ-EVEGETQKTEGDAQPESDGVEAPEAEE 2062
EGE ++ EE +P E GV+ K E E A E ET GD + +++ EA E EE
Sbjct: 901 GEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSET----GDYEEKAETEEAEEPEE 956
Query: 2063 EAQEAEGEVQEAEGEAHPESEDVDAQEAEGEA--QPESEGVEAPEAEGEAQKAEGIEAPE 2120
+ +E H +ED ++ +AE +A + + E V + + E E IE E
Sbjct: 957 DGEEHVC----VSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGE 1012
Query: 2121 TEGEAQPESEGIEAPEAEG--EAQPESEGVEAQD---AEGEAQPESEGIEAQEAEEEAQP 2175
E Q E E E +AE E + E E +EA+D A + E+ G E Q
Sbjct: 1013 AE---QSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPT 1069
Query: 2176 ELEGVEAPEAE------GEAQP---ESEGIEAPEAEGEAQPE----LEGVEAPEAEEEAQ 2222
+ G ++P E E P ESE + E E QPE G E ++
Sbjct: 1070 KQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSE 1129
Query: 2223 PEP-EGVETPEAEGEAQPESEGETQGEKKGSPQ---VSLGDGQSEEASESSSPVPEDRPT 2278
P P + + TP + ET E+ SP V++ +S S+ S + P
Sbjct: 1130 PTPMDEMSTP------RDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPADVTPL 1183
Query: 2279 PPPSPGGDTP-------HQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTR------- 2324
S G T + + + PSS + +D+ V T
Sbjct: 1184 NGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDIKDSI 1243
Query: 2325 ------------------SPDAKSTGTPHAERKATRMYPESS---TSEQEEAPLGSRTPE 2363
SP + TP ER + ++E E AP+ +
Sbjct: 1244 SAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSPEVTQ 1303
Query: 2364 QGASEGYDLQEDQALGSLAPTEAVGRADG 2392
+ E ED+ L ++P+++V + G
Sbjct: 1304 EVVEEHCASPEDKTLEVVSPSQSVTGSAG 1332
Score = 88.6 bits (218), Expect = 7e-17
Identities = 125/513 (24%), Positives = 198/513 (38%), Gaps = 56/513 (10%)
Query: 1819 AAGGDQDPG-------QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPES 1871
AAG ++ G + AE + A G A G A+E E E S
Sbjct: 772 AAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSLMS 831
Query: 1872 EDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGED 1931
+ + E + E DV +++P+ E E ++E ETE VEA + E
Sbjct: 832 SPEDLTKDFEELKAEEVDVTK-----DIKPQLELIE----DEEKLKETEPVEAYVIQKER 882
Query: 1932 EPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEG 1991
E AE+ + E EG+ + E +E E + E + E E ++ +
Sbjct: 883 EVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDY 942
Query: 1992 EAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPE 2051
E + E+E+ E PE +GE ++ E K+E +A E GD + E
Sbjct: 943 EEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEA-DAYIREKRESVASGDDRAE 1001
Query: 2052 SDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQ 2111
D EA E + EA+++E E E + E+ + ++ E E + +A EA G +
Sbjct: 1002 EDMDEAIE-KGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEE 1060
Query: 2112 KAEGIEAPETEGEAQPESEGIE-APEAEGEAQP---ESEGVEAQDAEGEAQPE----SEG 2163
+ + P + AQ S G E A E P ESE + + E QPE + G
Sbjct: 1061 QYGFLTTPTKQLGAQ--SPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSG 1118
Query: 2164 IEAQEAEEEAQP-ELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELE-GVEAPEAEEEA 2221
E ++P ++ + P + +E E+P E + E + + E + A
Sbjct: 1119 YTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESSLYSQEYSKPA 1178
Query: 2222 QPEP-----EGVETPEAEGE---------AQPESEGETQ-----------GEKKGSPQVS 2256
P EG +T +G+ + P S E + E K S +
Sbjct: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLD 1238
Query: 2257 LGDGQSEEASESSSPVPEDRPTP-PPSPGGDTP 2288
+ D S +SE SP +P PPSP TP
Sbjct: 1239 IKDSISAVSSEKVSPSKSPSLSPSPPSPLEKTP 1271
Score = 66.6 bits (161), Expect = 3e-10
Identities = 148/687 (21%), Positives = 250/687 (36%), Gaps = 110/687 (16%)
Query: 1757 DPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQG 1816
D + EG+ ++ + E ++ + E EG G E ETG +E+ +
Sbjct: 893 DEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETG----DYEEKAET 948
Query: 1817 EAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEA 1876
E A ++P + DG E + A + E E E+ +AE DA E S D A
Sbjct: 949 EEA----EEP-EEDGEEHV-CVSASKHSPTEDE--ESAKAEADAYIREKRESVASGDDRA 1000
Query: 1877 PEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESV-----EALETEGED 1931
E EA E + E E E + + ++E A E E E + V +A E G +
Sbjct: 1001 EEDMDEA-IEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAE 1059
Query: 1932 E-------PESEGAEAQEAEEAAQEAEGQTQP---ESEVIESQEAEEEAQPESEDV---- 1977
E P + E A +T P ESE S E E QPE
Sbjct: 1060 EQYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGY 1119
Query: 1978 --EALEVEVETQEAEGEAQPE---SEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE 2032
+E+ E + + P S++ E E QE + ES + +Q S+
Sbjct: 1120 TQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYES-SLYSQEYSKPA 1178
Query: 2033 EAQEVEG-----ETQKTEG-DAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVD 2086
+ + G +T T+G D + + P + EE + + +++A S +D
Sbjct: 1179 DVTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLD 1238
Query: 2087 AQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESE 2146
+++ E K ++P P S + P E
Sbjct: 1239 IKDSISAVSSE--------------KVSPSKSPSL--SPSPPSPLEKTPLGERSVNFSLT 1282
Query: 2147 GVEAQ-DAEGEAQPESEGIEAQEAEEE-AQPE---LEGVEAPEAEGEAQPESEGIEAPEA 2201
E + AE E P S + + EE A PE LE V ++ + + ++P
Sbjct: 1283 PNEIKVSAEAEVAPVSPEVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTD 1342
Query: 2202 EGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQ 2261
E + E +E P A P E +A+ E + S SP
Sbjct: 1343 EKSSHLPTEVIEKPPA------VPVSFEFSDAKDENERASV---------SP-------M 1380
Query: 2262 SEEASESSSPVPE--DRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHV 2319
E +S SP+ + PP G ++ ++ S +S R + +S +
Sbjct: 1381 DEPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADDKASGRGA--------ESPFEEK 1432
Query: 2320 LGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEE-APLGSRTPEQGASEGYDLQ----- 2373
G SPD S P +E +T +Y + + + AP+ ++ ++ +
Sbjct: 1433 SGKQGSPDQVS---PVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKTDDVEAMSSQPA 1489
Query: 2374 ---EDQALGSLAPTEA-VGRADGFGQD 2396
+++ LG ++PT+ V + F +D
Sbjct: 1490 LALDERKLGDVSPTQIDVSQFGSFKED 1516
Score = 65.1 bits (157), Expect = 8e-10
Identities = 105/519 (20%), Positives = 196/519 (37%), Gaps = 63/519 (12%)
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQ- 1964
A++ E+ K A S + E+ PE E + E + + I+++
Sbjct: 539 ADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTET 598
Query: 1965 --EAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDG 2022
E+ P E+ ++ EV A+ ++ DV+ A+ + + E + +PE
Sbjct: 599 KPSVTEKEVPSKEEPSPVKAEV--------AEKQATDVKPKAAKEKTVKKETKVKPEDKK 650
Query: 2023 VEAQ-PKSE------------------GEEAQEVEGETQKTEGDAQPESDGVEAPEAE-- 2061
E + PK E E +EV+ E +K E + E P E
Sbjct: 651 EEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVK 710
Query: 2062 -EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPE 2120
E +E + EV++ E E E + + ++A+ + P SE + + + K E +
Sbjct: 711 KEVKKEEKKEVKKEEKEPKKEIKKL-PKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKD 769
Query: 2121 TEGEAQPESEG-IEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEG 2179
+ +P+ +G I+ + EG+A A A + GI A +E + E
Sbjct: 770 SVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAKELEAERSL 829
Query: 2180 VEAPEAEGEAQPESEGIEAPEAE--GEAQPELEGVEAPEAEEEAQP-------------- 2223
+ +PE + + E ++A E + + +P+LE +E E +E +P
Sbjct: 830 MSSPE---DLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTK 886
Query: 2224 -----EPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPT 2278
EG+ T E EGE + E EK+G + + + ESS D
Sbjct: 887 GPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSE--TGDYEE 944
Query: 2279 PPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAER 2338
+ + P + S+S+ S + +E D + + R ++ ++G AE
Sbjct: 945 KAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAEADAYIREKR--ESVASGDDRAEE 1002
Query: 2339 KATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQA 2377
+ + EE E E Y+ ++ +A
Sbjct: 1003 DMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEKMEA 1041
Score = 56.2 bits (134), Expect = 4e-07
Identities = 114/552 (20%), Positives = 201/552 (36%), Gaps = 55/552 (9%)
Query: 1744 EDGE-----GSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGIS 1798
EDGE + + + +D + +AE DA +E+ + + A ++ EA ++GE
Sbjct: 956 EDGEEHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGE--- 1012
Query: 1799 ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGI-----EAPEAEGEAQPESEGVEA 1853
E + + ED + E A + +P + + + + +A EA G A+ + +
Sbjct: 1013 --AEQSEEEADEED--KAEDAREEEYEPEKMEAEDYVMAVVDKAAEA-GGAEEQYGFLTT 1067
Query: 1854 PEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEK 1913
P + AQ E D P ESE + E E QPE A + +
Sbjct: 1068 PTKQLGAQSPGREPASSIHDETLPGGS-----ESEATASDEENREDQPEEFTATSGYTQS 1122
Query: 1914 EAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPE 1973
+ +E E + S+ +E E +QE T+ ES + SQE + A +
Sbjct: 1123 TIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKYESS-LYSQEYSKPA--D 1179
Query: 1974 SEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEE 2033
+ +T +G+ S +P + E + A ++ E + + +
Sbjct: 1180 VTPLNGFSEGSKTDATDGKDYNASASTISPPSSMEEDKFSRSALRDAYCSEVKASTTLDI 1239
Query: 2034 AQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQ----------EAEGEAHPESE 2083
+ + + ++ S P E+ E V AE E P S
Sbjct: 1240 KDSISAVSSEKVSPSKSPSLSPSPPSPLEKTPLGERSVNFSLTPNEIKVSAEAEVAPVSP 1299
Query: 2084 DVDAQEAEGE-AQPESEGVE----APEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAE 2138
+V + E A PE + +E + G A ++P E + +E IE P A
Sbjct: 1300 EVTQEVVEEHCASPEDKTLEVVSPSQSVTGSAGHTPYYQSPTDEKSSHLPTEVIEKPPAV 1359
Query: 2139 ------GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPE---AEGEA 2189
+A+ E+E + E P+SE + P L G E+ +
Sbjct: 1360 PVSFEFSDAKDENERASVSPMD-EPVPDSESPIEKVLSPLRSPPLIGSESAYESFLSADD 1418
Query: 2190 QPESEGIEAPEAEGEAQPELEGVEAPEAEEEA----QPEPEGVETPEAEGEAQPESEGET 2245
+ G E+P E + +P +E + Q + EG T A + E +T
Sbjct: 1419 KASGRGAESPFEEKSGKQGSPDQVSPVSEMTSTSLYQDKQEGKSTDFAPIKEDFGQEKKT 1478
Query: 2246 QGEKKGSPQVSL 2257
+ S Q +L
Sbjct: 1479 DDVEAMSSQPAL 1490
Score = 48.1 bits (113), Expect = 1e-04
Identities = 63/254 (24%), Positives = 101/254 (39%), Gaps = 43/254 (16%)
Query: 1281 EEQRASSNLEQLAENTVQEEVQL-----EETKEG---TEGEGLQEEAVQLEETKTEEGL- 1331
E++ E + +Q+E ++ E EG TEGEG E+ + E ++G+
Sbjct: 862 EDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVD 921
Query: 1332 -----QEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386
++EG EE+ ET G EE+A+ EE EE +G EE V + K P
Sbjct: 922 DIEKFEDEGAGFEESSET---GDYEEKAETEEAEEPEEDG--EEHVCVSASKHSPTED-- 974
Query: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRA--SASAEPCPA 1444
EE K E + + + S AS D D+ +++ EA ++ A E
Sbjct: 975 ----EESAKAEA---DAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAE 1027
Query: 1445 EGTEEPTEPPSHLSE----------TDPSASERQSGSQLEPGLE---KPPGATMMGQEHT 1491
+ EE EP +E + +E Q G P + + PG H
Sbjct: 1028 DAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGAQSPGREPASSIHD 1087
Query: 1492 QAQPTQGAAERSSS 1505
+ P +E ++S
Sbjct: 1088 ETLPGGSESEATAS 1101
Score = 40.0 bits (92), Expect = 0.028
Identities = 69/330 (20%), Positives = 117/330 (35%), Gaps = 58/330 (17%)
Query: 1191 ENFTPTSSSGVD----ISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPD-SRTYE 1245
E P GVD G ESS + T+ E P + + S +
Sbjct: 910 EELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGEEHVCVSASKH 969
Query: 1246 SPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEE 1305
SP + E + ++ + + A+ +D AE D ++E
Sbjct: 970 SPTEDEESAKAEADAYIREKRESVASGDDRAEED-----------------------MDE 1006
Query: 1306 TKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGE 1365
E E E +EEA EE K E+ +E E E E + E+ + +++
Sbjct: 1007 AIEKGEAEQSEEEAD--EEDKAEDAREE---------EYEPEKMEAEDYVMAVVDKAAEA 1055
Query: 1366 GLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDD 1425
G EE G L + G + G S+H + L S + S E++
Sbjct: 1056 GGAEE----------QYGFLTTPTKQLGAQSPGREPASSIHDETLPGGSESEATASDEEN 1105
Query: 1426 PVQEEEAGRASASAEPCPAEGTEEPT-----EPPSHLSETDPSASERQSGSQLEPGLEKP 1480
+ E A++ E + EPT P + + + E +S SQ + K
Sbjct: 1106 REDQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDETNNEETESPSQEFVNITKY 1165
Query: 1481 PGATMMGQEHTQ---AQPTQGAAERSSSVA 1507
+++ QE+++ P G +E S + A
Sbjct: 1166 E-SSLYSQEYSKPADVTPLNGFSEGSKTDA 1194
Score = 39.3 bits (90), Expect = 0.047
Identities = 46/226 (20%), Positives = 95/226 (42%), Gaps = 8/226 (3%)
Query: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
V P ++ + + +E+ A ++ E PE V E + + E
Sbjct: 525 VPTPVVKQTKLKQRADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKE 584
Query: 2115 GIEAPETEG---EAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEE 2171
+ + + E +P E P E + ++E E Q + + + E +E +
Sbjct: 585 KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKV 644
Query: 2172 EAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPE-GVET 2230
+ + + E E P+ E + + I+ E + + + E + + EE+ +P+ E ET
Sbjct: 645 KPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
Query: 2231 P--EAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPE 2274
P E + E + E + E + E+K P+ + ++A +SS+P+ E
Sbjct: 705 PPKEVKKEVKKEEKKEVKKEEK-EPKKEI-KKLPKDAKKSSTPLSE 748
Score = 38.9 bits (89), Expect = 0.061
Identities = 63/351 (17%), Positives = 127/351 (36%), Gaps = 29/351 (8%)
Query: 1933 PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
PESEG + + + + P++ + AE+ + + E AE +
Sbjct: 2018 PESEGYSYETSTKTTRT------PDTSTYCYETAEKITRTPQASTYSYETSDLCYTAEKK 2071
Query: 1993 AQPES-EDVEAPEAEG-EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQP 2050
+ E+ +DV+ E + + E P EE E + G A P
Sbjct: 2072 SPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEEPTEESEKPLTQSGGAPP 2131
Query: 2051 ESDGVEAPEAEEEAQE---AEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAE 2107
G + +E +E + + + PE+E+ + A+ E E P +
Sbjct: 2132 PPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITADANIDSEDESETIPTDK 2191
Query: 2108 GEAQK-AEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQ-DAEGEAQPESEGIE 2165
K + AP + P + + E A ++ G + D + + + + G +
Sbjct: 2192 TVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTK 2251
Query: 2166 AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEP 2225
+ + + + G P A A P+ G++ E+ ++ V +P+ +E +
Sbjct: 2252 TKSSSPVKKSD--GKSKPLA---ASPKPAGLK------ESSDKVSRVASPKKKESVEKAA 2300
Query: 2226 EGVETPEAEGEAQPESEGETQ-----GEKKGSPQVSLGDGQSEEASESSSP 2271
+ TPE + E + ET+ K + + G G ++ S+ P
Sbjct: 2301 KPTTTPEVKAARGEEKDKETKNAANASASKSAKTATAGPGTTKTTKSSAVP 2351
Score = 35.8 bits (81), Expect = 0.52
Identities = 55/230 (23%), Positives = 89/230 (38%), Gaps = 20/230 (8%)
Query: 1277 ERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEG- 1335
E + E ++ LE + + V + + E+ G E + + ET+ E +E+G
Sbjct: 900 EGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGE 959
Query: 1336 ----VQLEETKETEGE--GQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEA 1389
V + TE E + E +A + E E+ G + E++ E E G + E
Sbjct: 960 EHVCVSASKHSPTEDEESAKAEADAYIREKRESVASG---DDRAEEDMDEAIEKG-EAEQ 1015
Query: 1390 LEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASAS----AEPCPAE 1445
EE EE E+ E + + D + D + EAG A P
Sbjct: 1016 SEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVD---KAAEAGGAEEQYGFLTTPTKQL 1072
Query: 1446 GTEEP-TEPPSHL-SETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
G + P EP S + ET P SE ++ + E E P +TQ+
Sbjct: 1073 GAQSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQS 1122
Score = 34.3 bits (77), Expect = 1.5
Identities = 50/241 (20%), Positives = 86/241 (35%), Gaps = 35/241 (14%)
Query: 1836 EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEA 1895
E P E E +P ++ AP G G+ Q D P + E+ P D + P
Sbjct: 2113 EEPTEESE-KPLTQSGGAPPPPG------GKQQGRQCDETPPTSVSESAPSQTDSDVP-- 2163
Query: 1896 EWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQ 1955
PE+E E P +A ++E E E P + + +
Sbjct: 2164 -----PETE--ECPSITADANIDSED------ESETIPTDKTVTYKHMD----------P 2200
Query: 1956 PESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEE 2015
P + V + + D EAL +E +A + E + P + + ++
Sbjct: 2201 PPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTKTKSSSPVKK 2260
Query: 2016 AQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES-DGVEAPEAEEEAQEAEGEVQEA 2074
+ +S + A PK G +E + + + ES + P E + A GE ++
Sbjct: 2261 SDGKSKPLAASPKPAG--LKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAARGEEKDK 2318
Query: 2075 E 2075
E
Sbjct: 2319 E 2319
Score = 33.5 bits (75), Expect = 2.6
Identities = 46/221 (20%), Positives = 80/221 (36%), Gaps = 26/221 (11%)
Query: 1821 GGDQDPGQSDGAEGIEAPEA-----EGEAQPESEGVEAPEAEGDAQ---EAEGEAQPESE 1872
GG Q Q D E+ + + PE+E E P DA E E E P +
Sbjct: 2134 GGKQQGRQCDETPPTSVSESAPSQTDSDVPPETE--ECPSITADANIDSEDESETIPTDK 2191
Query: 1873 DVE--------APEAEGEAQPESEDVETPEAEWEVQPESEGA----EAPEAEKEAQPETE 1920
V AP + P DV + E ++ G + E K +P T+
Sbjct: 2192 TVTYKHMDPPPAPVQDRSPSPRHPDVSMVDPEALAIEQNLGKALKKDLKEKTKTKKPGTK 2251
Query: 1921 ---SVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDV 1977
S +++G+ +P + + +E++ + P+ + + A+ PE +
Sbjct: 2252 TKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKESVEKAAKPTTTPEVKAA 2311
Query: 1978 EALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQP 2018
E + ET+ A + +S A G + + A P
Sbjct: 2312 RGEEKDKETKNAANASASKSAKT-ATAGPGTTKTTKSSAVP 2351
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 100 bits (248), Expect = 2e-20
Identities = 186/897 (20%), Positives = 307/897 (34%), Gaps = 106/897 (11%)
Query: 1425 DPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGAT 1484
+P E + ++ P P E E+ PP ++ D A+ +G + ++PP
Sbjct: 1675 EPATVSEEAKPASEPAPAPVEQLEQVDLPPG--ADPDKEAAMMPAGVEEGSSGDQPP--- 1729
Query: 1485 MMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRAR 1544
+ A+P A S + + +D +P L K +K+ A+ A
Sbjct: 1730 -----YLDAKPPTPGASFSQA---ESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATA 1781
Query: 1545 WGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQ 1604
D + + A E Q ++ L+ + + + P + A +
Sbjct: 1782 DAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVT 1841
Query: 1605 QRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVR 1664
++ R+ + + S R L +E E TA + + E P R
Sbjct: 1842 RKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRR 1901
Query: 1665 KKVSPMSPKATMG--ATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRT 1722
+ V S ATMG R P+KE + Q + RKR E EAA V P TR
Sbjct: 1902 RNVR--SVYATMGDHENRSPVKEPVE-QPRVTRKRLERELQEAAAVPTTPRRGRPPKTRR 1958
Query: 1723 VQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRD---KDPKLGEAEGDAMAQEREGKTH-- 1777
E +E E E ++ L + P+ + Q ++GK
Sbjct: 1959 RADEE-------------EENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPK 2005
Query: 1778 ------NSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDG 1831
+ T G ++G E E + E G + + AG D++P ++
Sbjct: 2006 VDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKD------AGTDKNPPETAP 2059
Query: 1832 AEGIEAPEAEGEAQPESEGVE-----APEAEGDAQEAEGEAQPESEDVEAPEAE-GEAQP 1885
E +E A + G A + + + P +A E E G
Sbjct: 2060 VEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAV 2119
Query: 1886 ESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEE 1945
E E+P+ E + S ++ + + +PE E V A G ++ A+ E E+
Sbjct: 2120 SPEKSESPQKEDGL---SSQLKSDPVDPDKEPEKEDVSA---SGPSPEATQLAKQMELEQ 2173
Query: 1946 AAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEV-EVETQEAEG----EAQPESEDV 2000
A + + + +A E PE D A + E E A G + E E+
Sbjct: 2174 AVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENF 2233
Query: 2001 EAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEA 2060
AP E++ + QP + QP EG E E +TE + V AP+
Sbjct: 2234 PAPPPYPG--ESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPD- 2290
Query: 2061 EEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPE 2120
P + D +EA G + S V PEA+G + + +
Sbjct: 2291 -------------------PSAGPTDTKEARGNSSETSHSV--PEAKGSKEVEVTLVRKD 2329
Query: 2121 TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGV 2180
+ S + A ES E+ A+GE+ +EG Q EA E +
Sbjct: 2330 KGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQ--HPEAPQEEKQS 2387
Query: 2181 EAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPE 2240
E P + S+ + P E +Q E+ E + P+ P A + +P+
Sbjct: 2388 EKPHSTPPQSCTSDLSKIPSTENSSQ-EISVEERTPTKASVPPDLPPPPQP-APVDEEPQ 2445
Query: 2241 SEGETQGEKKGSPQVSLGDGQSEEASESSSPVP-----EDRPTPPPSPGGDTPHQRP 2292
+ + P S+ S P+P PP G PHQ P
Sbjct: 2446 ARFRVHSIIESDPVT--------PPSDPSIPIPTLPSVTAAKLSPPVASGGIPHQSP 2494
Score = 87.4 bits (215), Expect = 2e-16
Identities = 138/654 (21%), Positives = 230/654 (35%), Gaps = 118/654 (18%)
Query: 1827 GQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPE 1886
G +G+ G + P + A+P + G +AE + QP S+ + E E + E
Sbjct: 1718 GVEEGSSGDQPPYLD--AKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAE 1775
Query: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
D T +AE + ++E A PE++ A + E + + + +S+ ++ A
Sbjct: 1776 KPDA-TADAEPDANQKAEAA--PESQPPASEDLEVDPPVAAKDKKPNKSKRSKTPVQAAA 1832
Query: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE-DVEAPEA 2005
E +SE I+ ++ + P E + LE+++E ++ A S D+E PE
Sbjct: 1833 VSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEP 1892
Query: 2006 EGEMQEAE--------------EEAQPESDGVEAQP----KSEGEEAQEVEGETQKTEGD 2047
+ E P + VE QP K E QE
Sbjct: 1893 SLPLSRTRRRNVRSVYATMGDHENRSPVKEPVE-QPRVTRKRLERELQEAAAVPTTPRRG 1951
Query: 2048 AQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDA----QEAEGEAQPESEGVEA 2103
P++ E E EA+E ++ EG P S+ A Q +G+ +P+ +
Sbjct: 1952 RPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATR- 2010
Query: 2104 PEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEA-----QPESEGVEAQDAEGEAQ 2158
PEA E G++ E +A E G E +A PE+ VE + + +
Sbjct: 2011 PEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPE 2070
Query: 2159 PESEG------------------------IEAQEAEEEAQPELEGVEAPEAEGEAQPESE 2194
S+ + + A +A GV A E P+ E
Sbjct: 2071 KNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKE 2130
Query: 2195 G-----IEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEK 2249
+++ + + +PE E V A EA + +E +A +E
Sbjct: 2131 DGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAKLAEASASAAY 2190
Query: 2250 KGSPQVSLG----DGQSEEASESS------------SPVPEDRPTPPPSPG-GDTPHQRP 2292
K L D + +ASE+ S PE+ P PPP PG T Q P
Sbjct: 2191 KADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPYPGESQTDLQPP 2250
Query: 2293 G-------SQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAE-------- 2337
S+ G + A S + +E+ + P A T T A
Sbjct: 2251 AGAQALQPSEEGMETDEAVSGILETEAATESSRPPVNAPDPSAGPTDTKEARGNSSETSH 2310
Query: 2338 ----------------------RKATRMYPESSTSEQEEAPLGSRTPEQGASEG 2369
+K TR + +T+++ AP+ S PE ++G
Sbjct: 2311 SVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQG 2364
Score = 84.0 bits (206), Expect = 2e-15
Identities = 138/662 (20%), Positives = 238/662 (35%), Gaps = 74/662 (11%)
Query: 1750 QRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSG 1809
+++ D + K+ + + D +E+E + + S + E + + ER E
Sbjct: 1498 KKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDS---- 1553
Query: 1810 HEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQ-PESEGVEAPEAEGDAQEAEGEAQ 1868
D + G G G + + I+ P ++ E ++ E E D + E E Q
Sbjct: 1554 --DFISGRIY-GKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQKEKEKDQKPKEVEKQ 1610
Query: 1869 PESEDVEAPEAEGEAQPESEDVE--TPEAEWEVQPESEGAEAPEAEKEAQPETESVEALE 1926
ED E E+ PE++D E TP + V P S E+ A +T + +E
Sbjct: 1611 ---EDTENHPKTPESAPENKDSELKTPPS---VGPPSVTVVTLESAPSALEKTTGDKTVE 1664
Query: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
P + E ++EA+ ++P +E E + D EA +
Sbjct: 1665 A-----PLVTEEKTVEPATVSEEAKPASEPAPAPVEQLEQVDLPPGADPDKEAAMMPAGV 1719
Query: 1987 QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVE--AQPKSEGEEAQEVEGETQKT 2044
+E QP D + P +AE PE D + ++P + EEA E + E
Sbjct: 1720 EEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDA 1779
Query: 2045 EGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAP 2104
DA+P+++ + EA E+Q E + E + ++D +++ P +
Sbjct: 1780 TADAEPDAN--QKAEAAPESQPPASE--DLEVDPPVAAKDKKPNKSKRSKTPVQAAAVSI 1835
Query: 2105 EAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPE---- 2160
+ +K+E I+ + + P E + E + EA+ + A PE
Sbjct: 1836 VEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKITRTASKNSAADLEHPEPSLP 1895
Query: 2161 -----SEGIEAQEA----EEEAQPELEGVEAPEA----------EGEAQPESEGIEAPEA 2201
+ + A E P E VE P E A P + P
Sbjct: 1896 LSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPK 1955
Query: 2202 EGEAQPELEGVEAPEAEEEAQPEPEGVETPEAE------------GEAQPESEG-ETQGE 2248
E E EA E E +P PEG +P ++ G+ +P+ + +
Sbjct: 1956 TRRRADEEEENEAKEPAETLKP-PEGWRSPRSQKTAAGGGPQGKKGKNEPKVDATRPEAT 2014
Query: 2249 KKGSPQVSLGDGQSEEAS---ESSSPVPEDR------PTPPPSPGGDTPHQRPGSQTGPS 2299
+ PQ+ + + E + E+ S DR PP + + ++P +
Sbjct: 2015 TEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSK 2074
Query: 2300 SSRASSWGNCWQKDSENDHVLGDTR-SPDAKSTGTPHAERKATRMYPESSTSEQEEAPLG 2358
S R S + D D SP + E + PE S S Q+E L
Sbjct: 2075 SKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLS 2134
Query: 2359 SR 2360
S+
Sbjct: 2135 SQ 2136
Score = 39.7 bits (91), Expect = 0.036
Identities = 82/364 (22%), Positives = 118/364 (32%), Gaps = 52/364 (14%)
Query: 783 SCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQ--RG 840
+ SK+ AA L + P+PS PL R + H P +P ++ + R
Sbjct: 1878 TASKNSAADL-----EHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRK 1932
Query: 841 PSPEASWLCGRYCPTPPRGRPCPQRRSSSC-----------------GSTGSSHQSTARG 883
TP RGRP RR + G Q TA G
Sbjct: 1933 RLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQKTAAG 1992
Query: 884 PGGSPQEGTRQPG-------PTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGG--- 933
G ++G +P T GP G S + A SE+K R G
Sbjct: 1993 GGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDAGTDK 2052
Query: 934 -PQGQEEASGVSPSSLPR---SSPEAVVREWLDNIPEEPILMTYELADETTGAA--GGGL 987
P V P S R + + L + A GAA G
Sbjct: 2053 NPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQAGER 2112
Query: 988 RGPEVDPGDDHSLEGLGEPAQAGQQSLEGDP-GQDPEPEGALLGSSDTGPQSGEGVPQGA 1046
V + S E + Q L+ DP D EPE + +S P++ + Q
Sbjct: 2113 ESGVVAVSPEKSESPQKEDGLSSQ--LKSDPVDPDKEPEKEDVSASGPSPEATQLAKQME 2170
Query: 1047 APEGV------SEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMRA---LMGSKQGRP 1097
+ V +EA A A +AP G R P ++ T++ A ++ G P
Sbjct: 2171 LEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEP 2230
Query: 1098 SSVP 1101
+ P
Sbjct: 2231 ENFP 2234
Score = 37.7 bits (86), Expect = 0.14
Identities = 90/427 (21%), Positives = 150/427 (35%), Gaps = 49/427 (11%)
Query: 447 RCSQDSASPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQI----GAERKAGGSLGED 502
+ ++ SAS A PEG PE P + A+ I E + +
Sbjct: 2180 KLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDISGEPENFPAPPPY 2239
Query: 503 PGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSAS-TGSHEGSSEWGGRPQGCPGKARA 561
PG L P L P SEEG +D + S E ++E P P +
Sbjct: 2240 PGE--SQTDLQPPAGAQALQP---SEEGMETDEAVSGILETEAATESSRPPVNAPDPSAG 2294
Query: 562 ETSQQEASEGGDPASPAL---------SLSSLRSDDLQAETQGQGTEQATGAAVTREPLV 612
T +EA S ++ ++ +R D + +T ++ T V P+
Sbjct: 2295 PTDTKEARGNSSETSHSVPEAKGSKEVEVTLVRKDKGRQKTTRSRRKRNTNKKVVA-PVE 2353
Query: 613 LGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSPSSP-----GLGRVAPRGHPRH 667
+ S ++G S + T+ Q + + S + P L ++ P
Sbjct: 2354 SHVPESNQAQGESPAANEGTTVQHPEAPQEEKQSEKPHSTPPQSCTSDLSKI-PSTENSS 2412
Query: 668 SHYRKDTHSPLDSSVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSL 727
+ +P +SV +P PP+ ++ R+ S S + PPS S+
Sbjct: 2413 QEISVEERTPTKASVPPDLPPPPQPAPVDEEPQA-RFRVHSIIE----SDPVTPPSDPSI 2467
Query: 728 PSQDLLGTSSATVTPAVHSDFVSGVSPHNAPS---AGW----AGDAGSRTCSPAPIPPHT 780
P L ++A ++P V SG PH +P W T SPA +PP T
Sbjct: 2468 PIPTLPSVTAAKLSPPV----ASGGIPHQSPPTKVTEWITRQEEPRAQSTPSPA-LPPDT 2522
Query: 781 SDSCSKSGAASLGEEARD------TPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPA 834
S + +++L + D T S+ + + P A H + +P
Sbjct: 2523 KASDVDTSSSTLRKILMDPKYVSATSVTSTSVTTAIAEPVSAAPCLHEAPPPPVDSKKPL 2582
Query: 835 QEAQRGP 841
+E P
Sbjct: 2583 EEKTAPP 2589
Score = 37.0 bits (84), Expect = 0.23
Identities = 27/91 (29%), Positives = 40/91 (43%), Gaps = 12/91 (13%)
Query: 1411 SEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASERQSG 1470
++ P+G+ Q PVQ + + A PCP +P +PP S P S+ G
Sbjct: 3341 AQGPPPEGEPLQPPQPVQSTQPAQP---APPCPPSQLGQPGQPP---SSKMPQVSQEAKG 3394
Query: 1471 SQLEPGLEKP----PGATMMGQEHTQAQPTQ 1497
+Q G+E+P A + HTQ Q Q
Sbjct: 3395 TQ--TGVEQPRLPAGPANRPPEPHTQVQRAQ 3423
Score = 35.8 bits (81), Expect = 0.52
Identities = 87/448 (19%), Positives = 149/448 (33%), Gaps = 66/448 (14%)
Query: 1832 AEGIEAPEAEGEAQPESEGVEAPEAEGDAQE----AEGEAQPESEDVEAPEAEGEAQPES 1887
A GI P+ PE + P + ++GE + + + P +PE+
Sbjct: 3059 AAGIPVPQFISSIHPEQSVIMPPHSITQTVSLSHLSQGEVRMNTPTL--PSITYSIRPEA 3116
Query: 1888 EDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDE-------PESEGAEA 1940
+ +P A +QP+ AP+ QP V AL ++ E P +
Sbjct: 3117 --LHSPRAP--LQPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAP 3172
Query: 1941 QEAEEAAQEAEGQTQP-----------------ESEVIESQEAEEEAQPESEDVEALEVE 1983
++E ++E + P SE + + + P S+ + E
Sbjct: 3173 VQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKE 3232
Query: 1984 -VETQEAEGEAQPESEDV--------EAPEAEGEMQEAEEEAQPESDGVEAQPK---SEG 2031
+T +A+ P V AP GE + + G+ P + G
Sbjct: 3233 AAKTPDAKAAPTPTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHG 3292
Query: 2032 EEAQEVEGE--TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAH---PESEDVD 2086
+ GE + GD + + + A + G + A PE E +
Sbjct: 3293 VQIVHSSGELFQEYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQ 3352
Query: 2087 AQEAEGEAQPESEGVEAPEAE-GEAQKAEGIEAPETEGEAQPESEGIEAPE--AEGEAQP 2143
+ QP P ++ G+ + + P+ EA+ G+E P A +P
Sbjct: 3353 PPQPVQSTQPAQPAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPAGPANRP 3412
Query: 2144 ESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEG 2203
+ Q A+ E P S +P+L V P QP + P G
Sbjct: 3413 PEPHTQVQRAQAETGPTS---FPSPVSVSMKPDLP-VSLPTQTAPKQP----LFVPTTSG 3464
Query: 2204 EAQPELEGVEAPEAEEEAQPEPEGVETP 2231
+ P G+ P E QP P+ +P
Sbjct: 3465 PSTP--PGLVLPHT--EFQPAPKQDSSP 3488
Score = 31.6 bits (70), Expect = 9.8
Identities = 71/331 (21%), Positives = 110/331 (33%), Gaps = 88/331 (26%)
Query: 2033 EAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQE----------------AEGEVQEAEG 2076
+ Q++E + QP GV A ++ +E +E V ++E
Sbjct: 3125 QPQQIEVRAPQRASTPQPAPAGVPALASQHPPEEEVHYHLPVARATAPVQSEVLVMQSEY 3184
Query: 2077 EAHPESEDVDAQ-------EAEGEAQPESEGV-------EAPEAEG-EAQKAEGIEAPET 2121
HP + D + A E ++GV +AP+ G EA K +A T
Sbjct: 3185 RLHPYTVPRDVRIMVHPHVTAVSEQPRAADGVVKVPPASKAPQQPGKEAAKTPDAKAAPT 3244
Query: 2122 EGEAQ---PESEGIEAPEAEGEAQ-----PESE--------------GVEAQDAEGEAQP 2159
A P AP GEA+ P ++ GV+ + GE
Sbjct: 3245 PTPAPVPVPVPLPAPAPAPHGEARILTVTPSNQLQGLPLTPPVVVTHGVQIVHSSGELFQ 3304
Query: 2160 ESEGIEAQEAEEEAQ------PELEGVEAPEAEGEAQ----PESEGIEAPEAEGEAQPEL 2209
E + + AQ P V P A PE E ++ P+ QP
Sbjct: 3305 EYRYGDIRTYHPPAQLTHTQFPAASSVGLPSRTKTAAQGPPPEGEPLQPPQPVQSTQPAQ 3364
Query: 2210 EGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESS 2269
P ++ +P + P+ EA+ G Q P++ G
Sbjct: 3365 PAPPCPPSQLGQPGQPPSSKMPQVSQEAKGTQTGVEQ------PRLPAG----------- 3407
Query: 2270 SPVPEDRPTPPPSPGGDTPHQRPGSQTGPSS 2300
P +RP P T QR ++TGP+S
Sbjct: 3408 ---PANRPPEP-----HTQVQRAQAETGPTS 3430
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 99.4 bits (246), Expect = 4e-20
Identities = 225/1089 (20%), Positives = 404/1089 (37%), Gaps = 131/1089 (12%)
Query: 1357 EEIEETGGEGLQEEGVQLEEVKEGPEGGLQ-GEALEEGLKEEGLPEEGSVHGQELSEASS 1415
++ E G + EE L+ K + E+ EE +EE E + S SS
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEE--EEEAEAETAKATPRLASTNSS 111
Query: 1416 PDG----KGSQEDDPVQEEEAGRASASAEPCPAEG--------------TEEPTEPPSHL 1457
G +E + E+AG+ S P PA G + EP+ + +
Sbjct: 112 VLGADLPSSMKEKAKAETEKAGKTGNSM-PHPATGKTVANLLSGKSPRKSAEPSANTTLV 170
Query: 1458 SETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPI 1517
SET+ S G+ +PG+ GQ + ++ T +++ + +
Sbjct: 171 SETEEEGSVPAFGAAAKPGM------VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224
Query: 1518 WVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQ 1577
SV K++ A V ++ + ++ L A+ ++ ++ ++ ++ E +
Sbjct: 225 ASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPAKRAKKPEEESESSEEGSESEEE 282
Query: 1578 KLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPL-SFTLEDE 1636
G ++ E +LQ + +G A G + S T +
Sbjct: 283 APAGTRSQVK--------ASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK 334
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRK 1696
P + S+ ++E EE +A ++ K S + + +GA P KE+ +
Sbjct: 335 PEEDSESSSEESSDSE-EETPAAKALLQAKASGKTSQ--VGAASAPAKES--------PR 383
Query: 1697 RGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEG-SQRLNRD 1755
+G AA PGKT V A+ G SQ + + E +Q
Sbjct: 384 KG------AAPAPPGKTGP------AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Query: 1756 KDPKLGEAEGDAMAQEREGKT-----HNSETSAGSELGEAEQEGEGISERGETGGQGSGH 1810
K P++ A A R+G +A ++G+ E++ SE ++ +
Sbjct: 432 KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491
Query: 1811 EDNLQGEAAAGGDQ-DPGQSDGAEGI---EAPEAEGEAQPESEGVEAPEAEGDAQEAEGE 1866
+ Q + Q P + G + P G+ P + + + E D+ E+ E
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS-ESSSE 550
Query: 1867 AQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALE 1926
+S D E P A AQ +S + +P S A+ P ++A P V+A +
Sbjct: 551 ESSDSSDGEVPTAVAPAQEKSLGNIL-----QAKPTSSPAKGPP--QKAGPVAVQVKAEK 603
Query: 1927 TEGEDEPESEGAEAQEAEEA-AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVE 1985
E E +++ ++EEA A Q +P ++ +++ ++ + + V V
Sbjct: 604 PMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS-AKVAPVRVG 662
Query: 1986 TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQP--ESDGVE---------AQPKSEGEEA 2034
TQ S +P G Q E++ ESD E Q KS G+
Sbjct: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722
Query: 2035 QEV-----------EGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE 2083
Q +G G P V+A E +E+++ +E E E A P
Sbjct: 723 QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA-EKQEDSESSEEESDSEEAAASPAQV 781
Query: 2084 DVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQP 2143
++ + +A P + AP A+G + + + + S+ ++ P P
Sbjct: 782 KTSVKKTQAKANPAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSK-VKPPVRN----P 834
Query: 2144 ESEGVEAQDAEGEAQPESEG-IEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAE 2202
++ V A+ G A S G A A+ + PE E G ++ ES+ E E
Sbjct: 835 QNSTVLAR---GPASVPSVGKAVATAAQAQTGPE-------EDSGSSEEESDSEEEAETL 884
Query: 2203 GEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPES-EGETQGEKKGSPQVSLGDGQ 2261
+ +P + + A A+ P P G+ P + + Q + S + S DG+
Sbjct: 885 AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 2262 SEEASESSSPV--PEDRPTPPPSPGGD--TPHQRPGSQTGPSSSRASSWGNCWQKDSEND 2317
+ A S+ + P P SP G TP Q + T + + S +SE++
Sbjct: 945 APAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDE 1004
Query: 2318 HVLGDTR--SPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQED 2375
V+ T+ +P + T R+ P++S + + SR + EG Q D
Sbjct: 1005 DVIPATQCLTPGIR-TNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVD 1063
Query: 2376 QALGSLAPT 2384
A+G+L T
Sbjct: 1064 SAVGTLPAT 1072
Score = 84.7 bits (208), Expect = 1e-15
Identities = 133/677 (19%), Positives = 254/677 (37%), Gaps = 48/677 (7%)
Query: 1744 EDGEGSQRLNRDKDP----KLGEAEGDAMAQEREGKTHNSETSA---GSELGEAEQEGEG 1796
ED + R DP + E E +A A+ + + T++ G++L + +E +
Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE-KA 125
Query: 1797 ISERGETGGQGSGHEDNLQGEAAAG--GDQDPGQS--DGAEGIEAPEAEGEAQPESEGVE 1852
+E + G G+ G+ A + P +S A E E E + G
Sbjct: 126 KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
Query: 1853 APEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE 1912
A A +A+ ++ S + + EG+ + V+ + P + A AP
Sbjct: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245
Query: 1913 KEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQP 1972
+ P+ + + +PE E ++E E+ +EA T+ + +++ E + +
Sbjct: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEKILQVRA 302
Query: 1973 ESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE 2032
S + + T G+A + +A + E + + + EE+ SD E P ++
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES---SDSEEETPAAKAL 359
Query: 2033 EAQEVEGETQKTEGDAQPESD-----GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDA 2087
+ G+T + + P + AP + A+ + + E ++ SE+ D+
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
Query: 2088 -QEAEGEAQPESEG--VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPE 2144
+EA +A+P + V A A + +G AP + P + ++ + E +++
Sbjct: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRKG-AAPAPPRKTGPAAAQVQVGKQEEDSRSS 478
Query: 2145 SEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGE 2204
SE ++ D E A + ++ + +P P +G A P G P A
Sbjct: 479 SEESDS-DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKG-AGPVPPGKVGP-ATPS 535
Query: 2205 AQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGE------TQGEKKGSPQVSLG 2258
AQ ++ + EE+ +G E P A AQ +S G T KG PQ +
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA-- 592
Query: 2259 DGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDH 2318
G ++ P+ + S D+ + P + T + A + +
Sbjct: 593 -GPVAVQVKAEKPMDNSESSEESSDSADS-EEAPAAMTAAQAKPALKIPQTKACPKKTNT 650
Query: 2319 VLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQAL 2378
+P T P AT S G++ P + +S + ++
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTAT-----SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
Query: 2379 GSLAPTEAVGRADGFGQ 2395
LA T VG+A G+
Sbjct: 706 TGLAVT--VGQAKSVGK 720
Score = 84.3 bits (207), Expect = 1e-15
Identities = 221/1106 (19%), Positives = 389/1106 (35%), Gaps = 176/1106 (15%)
Query: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
G A + G+ G + S S+ + +GK S V+ + +S S + PA
Sbjct: 183 GAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-----VKPAQVKASSVSTKESPAR- 236
Query: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPG--LEKPPGATMMGQEHTQAQPTQGAAERSS 1504
+ P + + P G L P +KP + +E ++++ A RS
Sbjct: 237 --KAAPAPGKVGDVTPQVK----GGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 1505 SVACSAALDCDPIWVSVLLKKTEKAFLAH--LASAVA-ELRARWGLQDNDLLDQMAAELQ 1561
A L + A A A AVA + +A +D++ + +++ +
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 1562 QDV--AQRLQDSTKRELQKLQGRAGRMVLEPPREAL-------TGELLLQTQQRRHRLRG 1612
++ A+ L + G A E PR+ TG + + Q +
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--- 407
Query: 1613 LRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSP 1672
E + S + E+ PA + G A P + RK +P P
Sbjct: 408 --------EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPP 456
Query: 1673 KATMGATRGPIKEAFDL--QQILQRKRGEHTDGE--------AAEVAP-GKT-HTDPTST 1720
+ T GP + Q+ R E +D + AA+V P GK+ P ST
Sbjct: 457 RKT-----GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 511
Query: 1721 RTVQGAEGGLGPGLSQGPG-VDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNS 1779
G+GP L +G G V G+ G + ++G+ E D+ + E + +S
Sbjct: 512 M-------GMGP-LGKGAGPVPPGKVGPATP------SAQVGKWEEDSESSSEES-SDSS 556
Query: 1780 ETSAGSELGEAEQEGEG-ISERGETGGQGSGHEDNLQGEAAAGGDQDP--------GQSD 1830
+ + + A+++ G I + T G A + P SD
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 1831 GAEGIEAPEAEGEAQPESEGVEAPEAEGDAQE----AEGEAQPESEDVEAPEAEGEAQPE 1886
A+ EAP A AQ + ++ P+ + ++ A + P +AP G A
Sbjct: 617 SADSEEAPAAMTAAQAKP-ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT-- 673
Query: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
S +P Q +E + + E E+ E E T G+ + +G + + A
Sbjct: 674 SPAGSSPAVAGGTQRPAEDSSSSE---ESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 1947 AQEAEGQ--------------TQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
+ + GQ TQ ++E E E+ EE + +SE+ A +V+T + +
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE-ESDSEEAAASPAQVKTSVKKTQ 789
Query: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052
A+ AP A+G + + + + P + + T G A S
Sbjct: 790 AKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Query: 2053 DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESE-----GVEAPEAE 2107
G +A A +A+ +E G + ES+ + E + +P + AP E
Sbjct: 850 VG----KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKE 905
Query: 2108 ----GEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQ----------DA 2153
G A G P + + G + E++ + + + AQ
Sbjct: 906 SPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPN 965
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE--------------SEGIEAP 2199
A P + +AQ A + A + E++ E + + P
Sbjct: 966 RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 1025
Query: 2200 EAEGEAQPELEGVEAPEAEEEA------QPEPEGVETPEAEGEAQPESEGETQGEKKGS- 2252
A P+ A ++E + + E + A G S T + KG+
Sbjct: 1026 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTN 1085
Query: 2253 -------PQVSL------GDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPS 2299
P+V SE++S+SSS ED P G + H + GP+
Sbjct: 1086 KLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGP---QGAKSAH----TLVGPT 1138
Query: 2300 SSRASSWGNCWQKDSENDHVLGDTRS--PDAKSTGTPHAERKATRMYPESSTSEQEEAPL 2357
SR + +S D V+ ++S + G A +A++ P+ +S + L
Sbjct: 1139 PSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTL 1198
Query: 2358 GSRTPEQGASEGYDLQEDQALGSLAP 2383
++ G E + QA G L+P
Sbjct: 1199 AAKDDPDGKQEA---KPQQAAGMLSP 1221
Score = 65.1 bits (157), Expect = 8e-10
Identities = 147/741 (19%), Positives = 265/741 (35%), Gaps = 95/741 (12%)
Query: 1649 EEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEV 1708
EE++ EE A V+ V KA A R P + I + +A +
Sbjct: 767 EESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG----TISAPGKVVTAAAQAKQR 822
Query: 1709 APGKT----HTDPTSTRTVQGAEG--GLGPGLSQGPGVDEG-EDGEGSQRLNRDKDPKLG 1761
+P K ST +G +G ++ G E+ GS D
Sbjct: 823 SPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS----- 877
Query: 1762 EAEGDAMAQER-EGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS--GHEDNLQGEA 1818
E E + +AQ + GKTH +A + E+ ++G + G+TG + G +D+
Sbjct: 878 EEEAETLAQVKPSGKTHQIR-AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD----- 931
Query: 1819 AAGGDQDPGQSDGAEGIEAPEAEGEAQ---PESEGVEAPEAEGDAQEAEGEAQPESEDVE 1875
+G + SDG EAP A AQ P V+ + +AQ S +
Sbjct: 932 -SGSSSEESDSDG----EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 986
Query: 1876 APEAEGEAQPESEDVETPEAEWEVQPESEGAEA-----PEAEKEAQPETESVEALETEGE 1930
A +E A+ S + E + Q + G P A P+ S+ + E
Sbjct: 987 ARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKA-SMAGASSSKE 1045
Query: 1931 DEPESEGAEAQEAEEAAQEAEGQ---TQPESEVIESQEAEEEAQPESEDVEALEVEVETQ 1987
S+G + + A G T P+S ++++ + +P+ +V+ +
Sbjct: 1046 SSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA---TKAP 1102
Query: 1988 EAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGD 2047
E+ +++ S+ E +GE + + A ++ ET E
Sbjct: 1103 ESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRT------------ETLVEETA 1150
Query: 2048 AQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAE 2107
A+ D V AP + + A +A + +D+ + + + + E
Sbjct: 1151 AESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQ-E 1209
Query: 2108 GEAQKAEGIEAPETEGE--AQPESEGIEAPEAEGEAQPESEGVEAQDA------------ 2153
+ Q+A G+ +P+T G+ A + +G P++ + Q
Sbjct: 1210 AKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPL 1269
Query: 2154 -EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEG-EAQPESEGIEAPEAEGEAQPELEG 2211
E + Q + + E+E + ++ + +G E++ + P A + +
Sbjct: 1270 NEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKK 1329
Query: 2212 VEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSP 2271
+ A E E A PE T ++G+A+ + EKKG SLG S
Sbjct: 1330 LGAGEGGE-ASVSPEKTSTT-SKGKAKRDKASGDVKEKKGKG--SLG-----------SQ 1374
Query: 2272 VPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKST 2331
+D P G T G Q+ P S + + +KD E + K +
Sbjct: 1375 GAKDEPEEELQKGMGTVEG--GDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDS 1432
Query: 2332 GTPHAERKATRMYPESSTSEQ 2352
+P ++K + T+EQ
Sbjct: 1433 ESPSQKKKKKK----KKTAEQ 1449
Score = 61.2 bits (147), Expect = 1e-08
Identities = 266/1415 (18%), Positives = 501/1415 (35%), Gaps = 208/1415 (14%)
Query: 778 PHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEA 837
PH + + + S G+ R + +PS+ L E+G+V + ++PG A +A
Sbjct: 140 PHPATGKTVANLLS-GKSPRKSAEPSANTTLVSETEEEGSVPAFGA--AAKPGMVSAGQA 196
Query: 838 QRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGG----------- 886
+S P +P Q ++SS + S + A PG
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPA-QVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG 255
Query: 887 --SPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTL--RSGGGPQGQEEASG 942
P + ++P S G+ A G S+ + EK L R+ P G
Sbjct: 256 ALPPAKRAKKP-EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
Query: 943 VSPSSLPRSSPEAVVREWLDNIPEEPILMTYELA---DETTGAAGGGLRGPEVDPGDDHS 999
+P+ P AV + PEE + E + +E T AA L+
Sbjct: 315 ATPA--PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA---------- 362
Query: 1000 LEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAG 1059
+ G+ +Q G S + P A TGP + G E + E+
Sbjct: 363 -KASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKA-QAGKREEDSQSSSEESD 418
Query: 1060 ADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALI 1119
++ EAPA + S +A R +++ A ++G + P + P A ++
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAP----AKESPRKGAAPAPPRKTGPAAAQVQVGKQEED 474
Query: 1120 TCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQ 1179
+ +S E+ S + ++ + + L S + P +G L G + +
Sbjct: 475 SRSSS-----EESDSDREALAAMNAAQVKPL-GKSPQVKPASTMGMGPLGKGAGPVPPGK 528
Query: 1180 ALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRP 1239
P S + + + SS + S S G ++V A + +L G L K P
Sbjct: 529 VGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL---GNILQAK-----P 580
Query: 1240 DSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQE 1299
S + P Q P + +A N + +E S+ + + +
Sbjct: 581 TSSPAKGP------PQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP 634
Query: 1300 EVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEE----------TKETEGEGQ 1349
+++ +TK + A + ++ G T+ +
Sbjct: 635 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694
Query: 1350 QEEEAQLEEIEETG-----------GEGLQEEGVQLE---EVKEGPEGGLQGEALEEGLK 1395
EE+ EE E+TG G+GLQ + + + +G L G+ +
Sbjct: 695 SSEESDSEE-EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQ 753
Query: 1396 EEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPS 1455
+ +E S +E S++ +Q V++ +A A+A A+GT P
Sbjct: 754 VKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT---ISAPG 810
Query: 1456 HLSETDPSASERQSGSQLEPGLEKPPGATMM----------GQEHTQAQPTQGAAERSSS 1505
+ A +R S S+++P + P +T++ G+ A Q E S
Sbjct: 811 KVVTAAAQAKQR-SPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG 869
Query: 1506 VACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDND--LLDQMAAEL-QQ 1562
+ + + +K + K A A A+ R G AA+ +Q
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQ 929
Query: 1563 DVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSER 1622
D + + + + + V++PP L+ R A +
Sbjct: 930 DDSGSSSEESDSDGEAPAAVTSAQVIKPP-------LIFVDPNRSPAGPAATPAQAQAAS 982
Query: 1623 TLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEAC----VRKKVSPM-------S 1671
T P + A S++ E+E E+ P C +R V M +
Sbjct: 983 T----PRKARASESTARSSS------SESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 1672 PKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLG 1731
PKA+M G + E++ ++ GK P + V A G L
Sbjct: 1033 PKASMA--------------------GASSSKESSRISDGKKQEGPATQ--VDSAVGTLP 1070
Query: 1732 PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE 1791
Q V +G+ +L + K P++ +A + + +S++S+GSE E
Sbjct: 1071 ATSPQSTSVQ----AKGTNKLRKPKLPEVQQAT--KAPESSDDSEDSSDSSSGSE--EDG 1122
Query: 1792 QEGEGISERGETGGQGSGHEDNLQGEAAAGGDQD----PGQS--DG--AEGIEAPEAEG- 1842
+ +G G + L E AA +D P QS G G+ ++
Sbjct: 1123 EGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQAS 1182
Query: 1843 EAQPE---SEGVEAPEAEGDAQEAEGEAQPE-SEDVEAPEAEGEAQPESEDVETPEAEWE 1898
+A P+ S V + A D + + EA+P+ + + +P+ G+ E+ TP+
Sbjct: 1183 KATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGK---EAASGTTPQKS-- 1237
Query: 1899 VQPESEGAEAPEAE-------------------KEAQPETESV----EALETEGEDEPES 1935
+ +GA P+A EAQ + V E LE E + ++
Sbjct: 1238 -RKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDT 1296
Query: 1936 EGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL-EVEVETQEAEGEAQ 1994
+++ E+ + QP + S++ ++ E + E T + + +
Sbjct: 1297 TKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD 1356
Query: 1995 PESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG 2054
S DV+ + +G + + +PE + + EG + + + +K + D + +
Sbjct: 1357 KASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDK- 1415
Query: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQE 2089
E E +++A++A + E+ + + + A++
Sbjct: 1416 -EKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1449
Score = 60.1 bits (144), Expect = 3e-08
Identities = 143/661 (21%), Positives = 245/661 (37%), Gaps = 99/661 (14%)
Query: 486 SAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGS 545
++++G +RKA ED L + P + E ++ ++ S S
Sbjct: 56 TSELGRKRKAE----EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSS 111
Query: 546 SEWGGRPQGCPGKARAETSQQEASEGGDP--------------ASPALSLSSLRSDDLQA 591
P KA+AET + + P SP S + L +
Sbjct: 112 VLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS 171
Query: 592 ETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSP 651
ET+ +G+ A GAA + G + S + +SS+ T + + + +AS++S+
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 652 SSPGLGRVAPRGHPRHSHYRKDTHSPLDSSV--TKQVPRPPERRRACQDGSVPRYSG-SS 708
SP A + P T ++ K+ +P E + ++GS +
Sbjct: 232 ESP-----ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 709 SSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGS 768
+ ++ +AS + + S P++ GT TPA G AG S
Sbjct: 287 TRSQVKASEKILQVRAASAPAK---GTPGKGATPA---------------PPGKAGAVAS 328
Query: 769 RTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPL-------VLQVGRPEQGA-VGP 820
+T + P DS S S +S EE +TP + L QVG A P
Sbjct: 329 QTKAGKP----EEDSESSSEESSDSEE--ETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 821 HRSHCCSQPG-TQPA-QEAQRGPSPEASWLCGRYCPT----PPRGRP---CPQRRSSSCG 871
+ + PG T PA +AQ G E S + P + +P PQ R++S
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
Query: 872 STGSSHQSTA------RGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGS-RGLSE 924
+ S + A GP + + +Q + S S + R + A+ A + L +
Sbjct: 443 AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 502
Query: 925 EKTLR----SGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETT 980
++ G GP G + A V P + ++P A V +W ++ E + E +
Sbjct: 503 SPQVKPASTMGMGPLG-KGAGPVPPGKVGPATPSAQVGKWEED---------SESSSEES 552
Query: 981 GAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEG---ALLGSSDTGPQ 1037
+ G V P + S LG QA S P + P + A+ ++
Sbjct: 553 SDSSDGEVPTAVAPAQEKS---LGNILQAKPTS---SPAKGPPQKAGPVAVQVKAEKPMD 606
Query: 1038 SGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGR--VSASTQIMRALMGSKQG 1095
+ E + + EAPA A + PA +A P + +AS ++ +G++
Sbjct: 607 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666
Query: 1096 R 1096
R
Sbjct: 667 R 667
Score = 55.5 bits (132), Expect = 6e-07
Identities = 275/1426 (19%), Positives = 491/1426 (34%), Gaps = 267/1426 (18%)
Query: 906 GASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWL-DNI 964
GA SS + A + KT S P + + + PR S E L
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 965 PEEPILMTYELADETTGAAGGGLRGPEVDPG---DDHSLEGLG--EPAQ--AGQQSLEGD 1017
EE + + A + + G D D+ +EG +PAQ A S +
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKES 233
Query: 1018 PGQDPEPEGALLGSSDTGPQ-SGEGVP---QGAAPEGVSEAPAEAG-ADREAPAGCRVSL 1072
P + P +G D PQ G +P + PE SE+ E ++ EAPAG R
Sbjct: 234 PARKAAPAPGKVG--DVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR--- 288
Query: 1073 RALPGRVSASTQIM--RALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEE 1130
+V AS +I+ RA +G P + P AGA+ + +
Sbjct: 289 ----SQVKASEKILQVRAASAPAKGTPGKGATPAPPG------KAGAVAS--------QT 330
Query: 1131 DLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMT 1190
G P +DS E S S++ P SG + + P S
Sbjct: 331 KAGKPE-----EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 1191 ENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDL 1250
P +G ++ G E + + + + K S + P R +P
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 1251 ENQQQCCF--PTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKE 1308
++ P A + E + S + + S+ E LA + L ++ +
Sbjct: 446 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 505
Query: 1309 ---------GTEGEG---LQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQL 1356
G G+G + V + G EE + + ++ + A
Sbjct: 506 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565
Query: 1357 EEIEETGGEGLQEE----------------GVQLEEVKEGPEGGLQGEALEEGLKEEG-- 1398
E++ G LQ + VQ++ K E+ + EE
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 625
Query: 1399 ------------LPEEGSVHGQELSEASS---PDGKGSQEDDPVQEEEAGRAS--ASAEP 1441
+P+ + + + AS+ P G+Q +AG A+ A + P
Sbjct: 626 AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP-----RKAGTATSPAGSSP 680
Query: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAE 1501
A GT+ P E S E+D + E ++G + G K G + Q + P +G+
Sbjct: 681 AVAGGTQRPAEDSSSSEESD--SEEEKTGLAVTVGQAKSVGKGL--QVKAASVPVKGSLG 736
Query: 1502 RSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQ 1561
+ ++ VL KT V +++A Q++ + ++ +
Sbjct: 737 QGTA--------------PVLPGKT--------GPTVTQVKAE--KQEDSESSEEESDSE 772
Query: 1562 QDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALT----GELLLQTQQRRHRLRG----- 1612
+ A Q K ++K Q +A P T G+++ Q + R
Sbjct: 773 EAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 830
Query: 1613 LRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEE-----AEGEEFCPCEACVRKKV 1667
+RN + L GP S + A++TA +Q G E +E E EA +V
Sbjct: 831 VRNPQ--NSTVLARGPASVPSVGK-AVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQV 887
Query: 1668 SPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAE 1727
P + A P KE+ ++G AA PGK T P++ + + +
Sbjct: 888 KPSGKTHQIRAALAPAKES--------PRKG------AAPTPPGK--TGPSAAQAGKQDD 931
Query: 1728 GGLGPGLSQGPGVDEGEDGEGSQRLNRDK---------DPKLGEA-----EGDAMAQERE 1773
G + DGE + + DP A A A
Sbjct: 932 SG-------SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
Query: 1774 GKTHNSETSAGSELGEAEQEG-----------------------EGISERGETGGQGSGH 1810
K SE++A S E+E E I+ + G S
Sbjct: 985 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK 1044
Query: 1811 EDN------------LQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPE----SEGVEAP 1854
E + Q ++A G P S + ++A +P+ + +AP
Sbjct: 1045 ESSRISDGKKQEGPATQVDSAVG--TLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAP 1102
Query: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEAQ----PESEDVETPEAEWEVQPESEGAEAPE 1910
E+ D++++ + ED E P+ A P ET E + + AP
Sbjct: 1103 ESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPS 1162
Query: 1911 AE-----------------KEAQPETESVEALETEGEDEPESEGAEAQEAEEAA------ 1947
+A P+ +S ++ + + + +G + + ++AA
Sbjct: 1163 QSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPK 1222
Query: 1948 ---QEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE-DVEAP 2003
+EA T P+ +S++ ++ A AL+ + TQ G+ P +E V+A
Sbjct: 1223 TGGKEAASGTTPQ----KSRKPKKGAGNPQASTLALQSNI-TQCLLGQPWPLNEAQVQAS 1277
Query: 2004 EAEGEMQEAEEEAQPESDGV-EAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEE 2062
+ + E+E + D E+ K +++ G+ + + A E E
Sbjct: 1278 VVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGE 1337
Query: 2063 EAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI------ 2116
+ E ++G+A + D +E +G+ S+G + E E E QK G
Sbjct: 1338 ASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAK-DEPEEELQKGMGTVEGGDQ 1396
Query: 2117 EAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
P+++ E + +S+ + + + E + +++ +D+E +Q + +
Sbjct: 1397 SNPKSKKE-KKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKK 1441
Score = 38.1 bits (87), Expect = 0.10
Identities = 107/516 (20%), Positives = 176/516 (34%), Gaps = 72/516 (13%)
Query: 455 PASSTG---LPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAG 511
PAS+ G L +G+ P P V A+PSAQ+G + S E+ DG
Sbjct: 508 PASTMGMGPLGKGAGP-------VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG-- 558
Query: 512 LGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKA-----RAETSQQ 566
E + P G + ++ +G + G P KA +E+S++
Sbjct: 559 ----EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG-PVAVQVKAEKPMDNSESSEE 613
Query: 567 EASEGGDPASPALSLSSLRSDDLQ-AETQGQGTEQATGAAVTREPLVLGL----SCSWDS 621
+ +PA ++ L+ +T+ + T A+ P+ +G +
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 622 EGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYR-KDTHSPLDS 680
A S+P+ +Q+ S + S GL + + K P+
Sbjct: 674 SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733
Query: 681 SVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATV 740
S+ + G+ P G + T TQ + S S D + A
Sbjct: 734 SLGQ--------------GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESD---SEEAAA 776
Query: 741 TPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTP 800
+PA V P+A A A +P + T+ + +K + S + P
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVV--TAAAQAKQRSPSKVKPPVRNP 834
Query: 801 QPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGR 860
Q S+ VL G +VG A +AQ GP E S +
Sbjct: 835 QNST--VLARGPASVPSVG---------KAVATAAQAQTGPE-EDSGSSEEESDSEEEAE 882
Query: 861 PCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSR 920
Q + S G +HQ A +P + + + G P+P +G S + Q
Sbjct: 883 TLAQVKPS-----GKTHQIRA---ALAPAKESPRKGAAPTPPGKTGPSAAQAGKQ--DDS 932
Query: 921 GLSEEKTLRSGGGPQGQEEASGVSPSSL---PRSSP 953
G S E++ G P A + P + P SP
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSP 968
Score = 33.5 bits (75), Expect = 2.6
Identities = 70/279 (25%), Positives = 100/279 (35%), Gaps = 68/279 (24%)
Query: 2133 EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA--QPELEGVEAPEAEGEAQ 2190
E E G+ ++ V D Q SE ++AEE+A Q + V P + E+
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 2191 PESEGIEAPEAEGEAQPELE-------GVEAPEAEEE--------------AQPEPEGVE 2229
E E EA A +A P L G + P + +E + P P +
Sbjct: 89 EEEEEAEAETA--KATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGK 146
Query: 2230 T-----------PEAEGEAQPESEGETQGE----------KKGSPQVSLGDGQSEEASES 2268
T AE A ET+ E K G D SE+ S S
Sbjct: 147 TVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS 206
Query: 2269 SSPVP-EDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPD 2327
S E +P+ P+ Q S S A +K + +GD +P
Sbjct: 207 SDETDVEGKPSVKPA-------QVKASSVSTKESPA-------RKAAPAPGKVGDV-TPQ 251
Query: 2328 AKSTGTPHAERKATRMYPESSTSE-----QEEAPLGSRT 2361
K P A+R A + ES +SE +EEAP G+R+
Sbjct: 252 VKGGALPPAKR-AKKPEEESESSEEGSESEEEAPAGTRS 289
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 99.4 bits (246), Expect = 4e-20
Identities = 225/1089 (20%), Positives = 404/1089 (37%), Gaps = 131/1089 (12%)
Query: 1357 EEIEETGGEGLQEEGVQLEEVKEGPEGGLQ-GEALEEGLKEEGLPEEGSVHGQELSEASS 1415
++ E G + EE L+ K + E+ EE +EE E + S SS
Sbjct: 54 QQTSELGRKRKAEEDAALQAKKTRVSDPISTSESSEE--EEEAEAETAKATPRLASTNSS 111
Query: 1416 PDG----KGSQEDDPVQEEEAGRASASAEPCPAEG--------------TEEPTEPPSHL 1457
G +E + E+AG+ S P PA G + EP+ + +
Sbjct: 112 VLGADLPSSMKEKAKAETEKAGKTGNSM-PHPATGKTVANLLSGKSPRKSAEPSANTTLV 170
Query: 1458 SETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPI 1517
SET+ S G+ +PG+ GQ + ++ T +++ + +
Sbjct: 171 SETEEEGSVPAFGAAAKPGM------VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVK 224
Query: 1518 WVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQ 1577
SV K++ A V ++ + ++ L A+ ++ ++ ++ ++ E +
Sbjct: 225 ASSVSTKESPARKAAPAPGKVGDVTPQ--VKGGALPPAKRAKKPEEESESSEEGSESEEE 282
Query: 1578 KLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPL-SFTLEDE 1636
G ++ E +LQ + +G A G + S T +
Sbjct: 283 APAGTRSQVK--------ASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGK 334
Query: 1637 PALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRK 1696
P + S+ ++E EE +A ++ K S + + +GA P KE+ +
Sbjct: 335 PEEDSESSSEESSDSE-EETPAAKALLQAKASGKTSQ--VGAASAPAKES--------PR 383
Query: 1697 RGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEG-SQRLNRD 1755
+G AA PGKT V A+ G SQ + + E +Q
Sbjct: 384 KG------AAPAPPGKTGP------AVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Query: 1756 KDPKLGEAEGDAMAQEREGKT-----HNSETSAGSELGEAEQEGEGISERGETGGQGSGH 1810
K P++ A A R+G +A ++G+ E++ SE ++ +
Sbjct: 432 KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAA 491
Query: 1811 EDNLQGEAAAGGDQ-DPGQSDGAEGI---EAPEAEGEAQPESEGVEAPEAEGDAQEAEGE 1866
+ Q + Q P + G + P G+ P + + + E D+ E+ E
Sbjct: 492 MNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDS-ESSSE 550
Query: 1867 AQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALE 1926
+S D E P A AQ +S + +P S A+ P ++A P V+A +
Sbjct: 551 ESSDSSDGEVPTAVAPAQEKSLGNIL-----QAKPTSSPAKGPP--QKAGPVAVQVKAEK 603
Query: 1927 TEGEDEPESEGAEAQEAEEA-AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVE 1985
E E +++ ++EEA A Q +P ++ +++ ++ + + V V
Sbjct: 604 PMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTAS-AKVAPVRVG 662
Query: 1986 TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQP--ESDGVE---------AQPKSEGEEA 2034
TQ S +P G Q E++ ESD E Q KS G+
Sbjct: 663 TQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGL 722
Query: 2035 QEV-----------EGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE 2083
Q +G G P V+A E +E+++ +E E E A P
Sbjct: 723 QVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKA-EKQEDSESSEEESDSEEAAASPAQV 781
Query: 2084 DVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQP 2143
++ + +A P + AP A+G + + + + S+ ++ P P
Sbjct: 782 KTSVKKTQAKANPAA--ARAPSAKGTISAPGKVVTAAAQAKQRSPSK-VKPPVRN----P 834
Query: 2144 ESEGVEAQDAEGEAQPESEG-IEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAE 2202
++ V A+ G A S G A A+ + PE E G ++ ES+ E E
Sbjct: 835 QNSTVLAR---GPASVPSVGKAVATAAQAQTGPE-------EDSGSSEEESDSEEEAETL 884
Query: 2203 GEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPES-EGETQGEKKGSPQVSLGDGQ 2261
+ +P + + A A+ P P G+ P + + Q + S + S DG+
Sbjct: 885 AQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGE 944
Query: 2262 SEEASESSSPV--PEDRPTPPPSPGGD--TPHQRPGSQTGPSSSRASSWGNCWQKDSEND 2317
+ A S+ + P P SP G TP Q + T + + S +SE++
Sbjct: 945 APAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDE 1004
Query: 2318 HVLGDTR--SPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQED 2375
V+ T+ +P + T R+ P++S + + SR + EG Q D
Sbjct: 1005 DVIPATQCLTPGIR-TNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVD 1063
Query: 2376 QALGSLAPT 2384
A+G+L T
Sbjct: 1064 SAVGTLPAT 1072
Score = 86.7 bits (213), Expect = 3e-16
Identities = 222/1145 (19%), Positives = 398/1145 (34%), Gaps = 153/1145 (13%)
Query: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGL-QEEAVQLEETKTE 1328
+++ DE + + + + ++ + +T + + G G+ Q + L K
Sbjct: 204 SSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA 263
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQL---EEIEETGGEGLQEEGVQLEEVKEGPEGGL 1385
+ +EE EE E+E E +Q+ E+I + +G + P G
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 1386 QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDP-----VQEEEAGRAS-ASA 1439
A + + G PEE S E+SS + S+E+ P +Q + +G+ S A
Sbjct: 324 GAVASQT---KAGKPEEDS-------ESSSEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Query: 1440 EPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGA 1499
PA+ + P+ +T P+ ++ Q+G + E +Q +
Sbjct: 374 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREED--------------------SQSS 413
Query: 1500 AERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAE 1559
+E S S + A K + KA ASA A+ R G A
Sbjct: 414 SEESDSEEEAPAQ----------AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
Query: 1560 LQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAF 1619
Q V ++ +DS R+ + REAL Q + ++
Sbjct: 464 AQVQVGKQEEDS----------RSSSEESDSDREALAAMNAAQVKPLG------KSPQVK 507
Query: 1620 SERTLGLGPLSFTL------EDEPALSTALGSQLGEEAEG---EEFCPCEACVRKKVSP- 1669
T+G+GPL + PA +A + E++E E + V V+P
Sbjct: 508 PASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPA 567
Query: 1670 --------MSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTR 1721
+ K T +GP ++A + ++ ++ + E + + +
Sbjct: 568 QEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Query: 1722 TVQGAEGGLGPGLSQGPGVDEGEDGEGSQ-----RLNRDKDPKLGEAEGDAMAQERE--G 1774
T A+ L + Q + + S R+ K G A A + G
Sbjct: 628 TAAQAKPALK--IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGG 685
Query: 1775 KTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAA---GGDQDPGQSDG 1831
+E S+ SE ++E+E G++ T GQ LQ +AA+ G G +
Sbjct: 686 TQRPAEDSSSSEESDSEEEKTGLAV---TVGQAKSVGKGLQVKAASVPVKGSLGQGTAPV 742
Query: 1832 AEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVE 1891
G P + E E+ E E D++EA A P + + +A P +
Sbjct: 743 LPGKTGPTVTQVKAEKQEDSESSEEESDSEEAA--ASPAQVKTSVKKTQAKANPAA--AR 798
Query: 1892 TPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA-AQEA 1950
P A+ + + A K+ P + A +A A A
Sbjct: 799 APSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAA 858
Query: 1951 EGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQ 2010
+ QT PE + S+E E +++ E+E + ++ +T + P E
Sbjct: 859 QAQTGPEEDSGSSEE-ESDSEEEAETLAQVKPSGKTHQIRAALAPAKES----------- 906
Query: 2011 EAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGE 2070
P P G A + + + +SDG EAP A AQ +
Sbjct: 907 -------PRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDG-EAPAAVTSAQVIKPP 958
Query: 2071 ---VQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPE--TEGEA 2125
V A P + AQ A + + A + E++ + I A + T G
Sbjct: 959 LIFVDPNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGI- 1017
Query: 2126 QPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEA 2185
+ + P A P++ A ++ E + +++ P + A
Sbjct: 1018 --RTNVVTMPTAHPRIAPKASMAGASSSK-------ESSRISDGKKQEGPATQVDSAVGT 1068
Query: 2186 EGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGET 2245
P+S ++A +P+L V ++A PE + E ++ SE +
Sbjct: 1069 LPATSPQSTSVQAKGTNKLRKPKLPEV------QQATKAPESSDDSEDSSDSSSGSEEDG 1122
Query: 2246 QGEKKGSPQVSLG--DGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRA 2303
+G + +LG ++E E ++ + PS + + PG P++S+A
Sbjct: 1123 EGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPG--LTPANSQA 1180
Query: 2304 SSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEE--APLGSRT 2361
S L PD K P ++ A + P++ E P SR
Sbjct: 1181 SKATPKLDSSPSVSSTLAAKDDPDGKQEAKP--QQAAGMLSPKTGGKEAASGTTPQKSRK 1238
Query: 2362 PEQGA 2366
P++GA
Sbjct: 1239 PKKGA 1243
Score = 84.7 bits (208), Expect = 1e-15
Identities = 133/677 (19%), Positives = 254/677 (37%), Gaps = 48/677 (7%)
Query: 1744 EDGEGSQRLNRDKDP----KLGEAEGDAMAQEREGKTHNSETSA---GSELGEAEQEGEG 1796
ED + R DP + E E +A A+ + + T++ G++L + +E +
Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE-KA 125
Query: 1797 ISERGETGGQGSGHEDNLQGEAAAG--GDQDPGQS--DGAEGIEAPEAEGEAQPESEGVE 1852
+E + G G+ G+ A + P +S A E E E + G
Sbjct: 126 KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
Query: 1853 APEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE 1912
A A +A+ ++ S + + EG+ + V+ + P + A AP
Sbjct: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245
Query: 1913 KEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQP 1972
+ P+ + + +PE E ++E E+ +EA T+ + +++ E + +
Sbjct: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEKILQVRA 302
Query: 1973 ESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE 2032
S + + T G+A + +A + E + + + EE+ SD E P ++
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES---SDSEEETPAAKAL 359
Query: 2033 EAQEVEGETQKTEGDAQPESD-----GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDA 2087
+ G+T + + P + AP + A+ + + E ++ SE+ D+
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
Query: 2088 -QEAEGEAQPESEG--VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPE 2144
+EA +A+P + V A A + +G AP + P + ++ + E +++
Sbjct: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRKG-AAPAPPRKTGPAAAQVQVGKQEEDSRSS 478
Query: 2145 SEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGE 2204
SE ++ D E A + ++ + +P P +G A P G P A
Sbjct: 479 SEESDS-DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKG-AGPVPPGKVGP-ATPS 535
Query: 2205 AQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGE------TQGEKKGSPQVSLG 2258
AQ ++ + EE+ +G E P A AQ +S G T KG PQ +
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA-- 592
Query: 2259 DGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDH 2318
G ++ P+ + S D+ + P + T + A + +
Sbjct: 593 -GPVAVQVKAEKPMDNSESSEESSDSADS-EEAPAAMTAAQAKPALKIPQTKACPKKTNT 650
Query: 2319 VLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQAL 2378
+P T P AT S G++ P + +S + ++
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTAT-----SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
Query: 2379 GSLAPTEAVGRADGFGQ 2395
LA T VG+A G+
Sbjct: 706 TGLAVT--VGQAKSVGK 720
Score = 84.0 bits (206), Expect = 2e-15
Identities = 220/1106 (19%), Positives = 387/1106 (34%), Gaps = 177/1106 (16%)
Query: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
G A + G+ G + S S+ + +GK S V+ + +S S + PA
Sbjct: 183 GAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-----VKPAQVKASSVSTKESPAR- 236
Query: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPG--LEKPPGATMMGQEHTQAQPTQGAAERSS 1504
+ P + + P G L P +KP + +E ++++ A RS
Sbjct: 237 --KAAPAPGKVGDVTPQVK----GGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 1505 SVACSAALDCDPIWVSVLLKKTEKAFLAH--LASAVA-ELRARWGLQDNDLLDQMAAELQ 1561
A L + A A A AVA + +A +D++ + +++ +
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 1562 QDV--AQRLQDSTKRELQKLQGRAGRMVLEPPREAL-------TGELLLQTQQRRHRLRG 1612
++ A+ L + G A E PR+ TG + + Q +
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--- 407
Query: 1613 LRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSP 1672
E + S + E+ PA + G A P + RK +P P
Sbjct: 408 --------EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPP 456
Query: 1673 KATMGATRGPIKEAFDL--QQILQRKRGEHTDGE--------AAEVAP-GKT-HTDPTST 1720
+ T GP + Q+ R E +D + AA+V P GK+ P ST
Sbjct: 457 RKT-----GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 511
Query: 1721 RTVQGAEGGLGPGLSQGPG-VDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNS 1779
G+GP L +G G V G+ G + ++G+ E D+ + E + +S
Sbjct: 512 M-------GMGP-LGKGAGPVPPGKVGPATP------SAQVGKWEEDSESSSEES-SDSS 556
Query: 1780 ETSAGSELGEAEQEGEG-ISERGETGGQGSGHEDNLQGEAAAGGDQDP--------GQSD 1830
+ + + A+++ G I + T G A + P SD
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 1831 GAEGIEAPEAEGEAQPESEGVEAPEAEGDAQE----AEGEAQPESEDVEAPEAEGEAQPE 1886
A+ EAP A AQ + ++ P+ + ++ A + P +AP G A
Sbjct: 617 SADSEEAPAAMTAAQAKP-ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT-- 673
Query: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
S +P Q +E + + E E+ E E T G+ + +G + + A
Sbjct: 674 SPAGSSPAVAGGTQRPAEDSSSSE---ESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 1947 AQEAEGQ--------------TQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
+ + GQ TQ ++E E E+ EE + +SE+ A +V+T + +
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE-ESDSEEAAASPAQVKTSVKKTQ 789
Query: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052
A+ AP A+G + + + + P + + T G A S
Sbjct: 790 AKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Query: 2053 DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESE-----GVEAPEAE 2107
G +A A +A+ +E G + ES+ + E + +P + AP E
Sbjct: 850 VG----KAVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKE 905
Query: 2108 ----GEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQ----------DA 2153
G A G P + + G + E++ + + + AQ
Sbjct: 906 SPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPN 965
Query: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPE--------------SEGIEAP 2199
A P + +AQ A + A + E++ E + + P
Sbjct: 966 RSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMP 1025
Query: 2200 EAEGEAQPELEGVEAPEAEEEA------QPEPEGVETPEAEGEAQPESEGETQGEKKGS- 2252
A P+ A ++E + + E + A G S T + KG+
Sbjct: 1026 TAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTN 1085
Query: 2253 -------PQVSL------GDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPS 2299
P+V SE++S+SSS ED P + T GP+
Sbjct: 1086 KLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHT--------LGPT 1137
Query: 2300 SSRASSWGNCWQKDSENDHVLGDTRS--PDAKSTGTPHAERKATRMYPESSTSEQEEAPL 2357
SR + +S D V+ ++S + G A +A++ P+ +S + L
Sbjct: 1138 PSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTL 1197
Query: 2358 GSRTPEQGASEGYDLQEDQALGSLAP 2383
++ G E + QA G L+P
Sbjct: 1198 AAKDDPDGKQEA---KPQQAAGMLSP 1220
Score = 67.4 bits (163), Expect = 2e-10
Identities = 145/735 (19%), Positives = 265/735 (36%), Gaps = 84/735 (11%)
Query: 1649 EEAEGEEFCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEV 1708
EE++ EE A V+ V KA A R P + I + +A +
Sbjct: 767 EESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKG----TISAPGKVVTAAAQAKQR 822
Query: 1709 APGKT----HTDPTSTRTVQGAEG--GLGPGLSQGPGVDEG-EDGEGSQRLNRDKDPKLG 1761
+P K ST +G +G ++ G E+ GS D
Sbjct: 823 SPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDS----- 877
Query: 1762 EAEGDAMAQER-EGKTHNSETSAGSELGEAEQEGEGISERGETGGQGS--GHEDNLQGEA 1818
E E + +AQ + GKTH +A + E+ ++G + G+TG + G +D+
Sbjct: 878 EEEAETLAQVKPSGKTHQIR-AALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDD----- 931
Query: 1819 AAGGDQDPGQSDGAEGIEAPEAEGEAQ---PESEGVEAPEAEGDAQEAEGEAQPESEDVE 1875
+G + SDG EAP A AQ P V+ + +AQ S +
Sbjct: 932 -SGSSSEESDSDG----EAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRK 986
Query: 1876 APEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPES 1935
A +E A+ S + E + Q + G T V P++
Sbjct: 987 ARASESTARSSSSESEDEDVIPATQCLTPGIR-----------TNVVTMPTAHPRIAPKA 1035
Query: 1936 EGAEAQEAEEAAQEAEGQTQ--PESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEA 1993
A A ++E+++ ++G+ Q P ++V + P+S V+A + E
Sbjct: 1036 SMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEV 1095
Query: 1994 QPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESD 2053
Q ++ E+ + + ++ ++ + +G + + ET E A+ D
Sbjct: 1096 QQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSED 1155
Query: 2054 GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKA 2113
V AP + + A +A + +D+ + + + + E + Q+A
Sbjct: 1156 DVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQ-EAKPQQA 1214
Query: 2114 EGIEAPETEGE--AQPESEGIEAPEAEGEAQPESEGVEAQDA-------------EGEAQ 2158
G+ +P+T G+ A + +G P++ + Q E + Q
Sbjct: 1215 AGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQ 1274
Query: 2159 PESEGIEAQEAEEEAQPELEGVEAPEAEG-EAQPESEGIEAPEAEGEAQPELEGVEAPEA 2217
+ + E+E + ++ + +G E++ + P A + + + A E
Sbjct: 1275 ASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEG 1334
Query: 2218 EEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRP 2277
E A PE T ++G+A+ + EKKG SLG S +D P
Sbjct: 1335 GE-ASVSPEKTSTT-SKGKAKRDKASGDVKEKKGKG--SLG-----------SQGAKDEP 1379
Query: 2278 TPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPDAKSTGTPHAE 2337
G T G Q+ P S + + +KD E + K + +P +
Sbjct: 1380 EEELQKGMGTVEG--GDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQK 1437
Query: 2338 RKATRMYPESSTSEQ 2352
+K + T+EQ
Sbjct: 1438 KKKKK----KKTAEQ 1448
Score = 64.7 bits (156), Expect = 1e-09
Identities = 272/1417 (19%), Positives = 505/1417 (35%), Gaps = 213/1417 (15%)
Query: 778 PHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEA 837
PH + + + S G+ R + +PS+ L E+G+V + ++PG A +A
Sbjct: 140 PHPATGKTVANLLS-GKSPRKSAEPSANTTLVSETEEEGSVPAFGA--AAKPGMVSAGQA 196
Query: 838 QRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGG----------- 886
+S P +P Q ++SS + S + A PG
Sbjct: 197 DSSSEDTSSSSDETDVEGKPSVKPA-QVKASSVSTKESPARKAAPAPGKVGDVTPQVKGG 255
Query: 887 --SPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTL--RSGGGPQGQEEASG 942
P + ++P S G+ A G S+ + EK L R+ P G
Sbjct: 256 ALPPAKRAKKP-EEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKG 314
Query: 943 VSPSSLPRSSPEAVVREWLDNIPEEPILMTYELA---DETTGAAGGGLRGPEVDPGDDHS 999
+P+ P AV + PEE + E + +E T AA L+
Sbjct: 315 ATPA--PPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQA---------- 362
Query: 1000 LEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAPAEAG 1059
+ G+ +Q G S + P A TGP + G E + E+
Sbjct: 363 -KASGKTSQVGAASAPAK--ESPRKGAAPAPPGKTGPAVAKA-QAGKREEDSQSSSEESD 418
Query: 1060 ADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALI 1119
++ EAPA + S +A R +++ A ++G + P + P A ++
Sbjct: 419 SEEEAPAQAKPSGKAPQVRAASAP----AKESPRKGAAPAPPRKTGPAAAQVQVGKQEED 474
Query: 1120 TCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQ 1179
+ +S E+ S + ++ + + L S + P +G L G + +
Sbjct: 475 SRSSS-----EESDSDREALAAMNAAQVKPL-GKSPQVKPASTMGMGPLGKGAGPVPPGK 528
Query: 1180 ALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRP 1239
P S + + + SS + S S G ++V A + +L G L K P
Sbjct: 529 VGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSL---GNILQAK-----P 580
Query: 1240 DSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQE 1299
S + P Q P + +A N + +E S+ + + +
Sbjct: 581 TSSPAKGP------PQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKP 634
Query: 1300 EVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEE----------TKETEGEGQ 1349
+++ +TK + A + ++ G T+ +
Sbjct: 635 ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSS 694
Query: 1350 QEEEAQLEEIEETG-----------GEGLQEEGVQLE---EVKEGPEGGLQGEALEEGLK 1395
EE+ EE E+TG G+GLQ + + + +G L G+ +
Sbjct: 695 SSEESDSEE-EKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQ 753
Query: 1396 EEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPS 1455
+ +E S +E S++ +Q V++ +A A+A A+GT P
Sbjct: 754 VKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGT---ISAPG 810
Query: 1456 HLSETDPSASERQSGSQLEPGLEKPPGATMM----------GQEHTQAQPTQGAAERSSS 1505
+ A +R S S+++P + P +T++ G+ A Q E S
Sbjct: 811 KVVTAAAQAKQR-SPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSG 869
Query: 1506 VACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDND--LLDQMAAEL-QQ 1562
+ + + +K + K A A A+ R G AA+ +Q
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQ 929
Query: 1563 DVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSER 1622
D + + + + + V++PP L+ R A +
Sbjct: 930 DDSGSSSEESDSDGEAPAAVTSAQVIKPP-------LIFVDPNRSPAGPAATPAQAQAAS 982
Query: 1623 TLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEAC----VRKKVSPM-------S 1671
T P + A S++ E+E E+ P C +R V M +
Sbjct: 983 T----PRKARASESTARSSS------SESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIA 1032
Query: 1672 PKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLG 1731
PKA+M G + E++ ++ GK P + V A G L
Sbjct: 1033 PKASMA--------------------GASSSKESSRISDGKKQEGPATQ--VDSAVGTLP 1070
Query: 1732 PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE 1791
Q V +G+ +L + PKL E + A E + +SE S+ S G +E
Sbjct: 1071 ATSPQSTSVQ----AKGTNKLRK---PKLPEVQQATKAPE---SSDDSEDSSDSSSG-SE 1119
Query: 1792 QEGEGI--SERGETGGQGSGHEDNLQGEAAAGGDQD----PGQS--DG--AEGIEAPEAE 1841
++GEG ++ T G + L E AA +D P QS G G+ ++
Sbjct: 1120 EDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQ 1179
Query: 1842 G-EAQPE---SEGVEAPEAEGDAQEAEGEAQPE-SEDVEAPEAEGEAQPESEDVETPEAE 1896
+A P+ S V + A D + + EA+P+ + + +P+ G+ E+ TP+
Sbjct: 1180 ASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGK---EAASGTTPQKS 1236
Query: 1897 WEVQPESEGAEAPEAE-------------------KEAQPETESV----EALETEGEDEP 1933
+ +GA P+A EAQ + V E LE E +
Sbjct: 1237 ---RKPKKGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVV 1293
Query: 1934 ESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEAL-EVEVETQEAEGE 1992
++ +++ E+ + QP + S++ ++ E + E T + + +
Sbjct: 1294 DTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAK 1353
Query: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052
S DV+ + +G + + +PE + + EG + + + +K + D + +
Sbjct: 1354 RDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKD 1413
Query: 2053 DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQE 2089
E E +++A++A + E+ + + + A++
Sbjct: 1414 K--EKKEKKKKAKKASTKDSESPSQKKKKKKKKTAEQ 1448
Score = 60.5 bits (145), Expect = 2e-08
Identities = 304/1548 (19%), Positives = 531/1548 (34%), Gaps = 263/1548 (16%)
Query: 486 SAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGS 545
++++G +RKA ED L + P + E ++ ++ S S
Sbjct: 56 TSELGRKRKAE----EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSS 111
Query: 546 SEWGGRPQGCPGKARAETSQQEASEGGDP--------------ASPALSLSSLRSDDLQA 591
P KA+AET + + P SP S + L +
Sbjct: 112 VLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS 171
Query: 592 ETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSP 651
ET+ +G+ A GAA + G + S + +SS+ T + + + +AS++S+
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 652 SSPGLGRVAPRGHPRHSHYRKDTHSPLDSSV--TKQVPRPPERRRACQDGSVPRYSG-SS 708
SP A + P T ++ K+ +P E + ++GS +
Sbjct: 232 ESP-----ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 709 SSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGS 768
+ ++ +AS + + S P++ GT TPA G AG S
Sbjct: 287 TRSQVKASEKILQVRAASAPAK---GTPGKGATPA---------------PPGKAGAVAS 328
Query: 769 RTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPL-------VLQVGRPEQGA-VGP 820
+T + P DS S S +S EE +TP + L QVG A P
Sbjct: 329 QTKAGKP----EEDSESSSEESSDSEE--ETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 821 HRSHCCSQPG-TQPA-QEAQRGPSPEASWLCGRYCPT----PPRGRP---CPQRRSSSCG 871
+ + PG T PA +AQ G E S + P + +P PQ R++S
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
Query: 872 STGSSHQSTA------RGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGS-RGLSE 924
+ S + A GP + + +Q + S S + R + A+ A + L +
Sbjct: 443 AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 502
Query: 925 EKTLR----SGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETT 980
++ G GP G + A V P + ++P A V +W ++ E + E +
Sbjct: 503 SPQVKPASTMGMGPLG-KGAGPVPPGKVGPATPSAQVGKWEED---------SESSSEES 552
Query: 981 GAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEG---ALLGSSDTGPQ 1037
+ G V P + S LG QA S P + P + A+ ++
Sbjct: 553 SDSSDGEVPTAVAPAQEKS---LGNILQAKPTS---SPAKGPPQKAGPVAVQVKAEKPMD 606
Query: 1038 SGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGR--VSASTQIMRALMGSKQG 1095
+ E + + EAPA A + PA +A P + +AS ++ +G++
Sbjct: 607 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666
Query: 1096 RPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSPRYQELLSISK 1155
R A + AG+ Q ED S ++S +E ++
Sbjct: 667 R----------KAGTATSPAGSSPAVAGGTQRPAEDSSSS------EESDSEEEKTGLAV 710
Query: 1156 DLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSV 1215
+ VG+ GL ++ V + GS G G + V
Sbjct: 711 TVGQAKSVGK-----GL----------------------QVKAASVPV-KGSLGQGTAPV 742
Query: 1216 PCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDE 1275
G VTQ +K Q DS + E D E + + N
Sbjct: 743 LPGKTGPTVTQ-----VKAEKQE-DSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAA 796
Query: 1276 AERDS-----------------EEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEE 1318
A S +QR+ S ++ N Q L G
Sbjct: 797 ARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNP-QNSTVLARGPASVPSVGKAVA 855
Query: 1319 AVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQ-LEEIEETGGEGLQEEGVQLEEV 1377
+T EE ++ +E E EEEA+ L +++ +G + L
Sbjct: 856 TAAQAQTGPEE----------DSGSSEEESDSEEEAETLAQVKPSG--KTHQIRAALAPA 903
Query: 1378 KEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASA 1437
KE P G P G ++A D GS ++ + EA A
Sbjct: 904 KESPRKG-------------AAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVT 950
Query: 1438 SAEPC-PAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPT 1496
SA+ P +P P+ P+A+ Q+ + P + +T A+ +
Sbjct: 951 SAQVIKPPLIFVDPNRSPA-----GPAATPAQAQAASTPRKARASEST--------ARSS 997
Query: 1497 QGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQM 1556
+E + + L I +V+ T +A AS ++ + +D Q
Sbjct: 998 SSESEDEDVIPATQCL-TPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRISDGKKQE 1056
Query: 1557 AAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNL 1616
Q D A +T + +Q + + +P + + + + +
Sbjct: 1057 GPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEV--QQATKAPESSDDSEDSSDS 1114
Query: 1617 SAFSERTLGLGP----LSFTLEDEPA-LSTALGSQLGEEAEGEEFCPCEACVRKKVSPMS 1671
S+ SE G GP + TL P+ T + E +E + P ++ + ++P
Sbjct: 1115 SSGSEED-GEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGL 1173
Query: 1672 PKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLG 1731
A A++ K L + A + GK P Q A G L
Sbjct: 1174 TPANSQASKATPK--------LDSSPSVSSTLAAKDDPDGKQEAKP------QQAAGMLS 1219
Query: 1732 PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQE--------------REGKTH 1777
P G E G Q+ + K G + +A + E +
Sbjct: 1220 P----KTGGKEAASGTTPQKSRKPK-KGAGNPQASTLALQSNITQCLLGQPWPLNEAQVQ 1274
Query: 1778 NSETSAGSELGEAEQEGEGISERGETGGQG-SGHEDNLQGEAAAG---GDQDPGQSDGAE 1833
S +EL E E++ + + E+ +G + L G+ A + + E
Sbjct: 1275 ASVVKVLTELLEQERK-KVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGE 1333
Query: 1834 GIEAPEAEGEAQPESEG-VEAPEAEGDAQEAEGEAQPESEDV-EAPEAE---GEAQPESE 1888
G EA + + S+G + +A GD +E +G+ S+ + PE E G E
Sbjct: 1334 GGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGG 1393
Query: 1889 DVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESE 1936
D P++ + E + ++ + +KE + + + + T+ + P +
Sbjct: 1394 DQSNPKS----KKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQK 1437
Score = 55.8 bits (133), Expect = 5e-07
Identities = 275/1425 (19%), Positives = 491/1425 (34%), Gaps = 266/1425 (18%)
Query: 906 GASRRSSASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWL-DNI 964
GA SS + A + KT S P + + + PR S E L
Sbjct: 114 GADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSET 173
Query: 965 PEEPILMTYELADETTGAAGGGLRGPEVDPG---DDHSLEGLG--EPAQ--AGQQSLEGD 1017
EE + + A + + G D D+ +EG +PAQ A S +
Sbjct: 174 EEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKES 233
Query: 1018 PGQDPEPEGALLGSSDTGPQ-SGEGVP---QGAAPEGVSEAPAEAG-ADREAPAGCRVSL 1072
P + P +G D PQ G +P + PE SE+ E ++ EAPAG R
Sbjct: 234 PARKAAPAPGKVG--DVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTR--- 288
Query: 1073 RALPGRVSASTQIM--RALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEE 1130
+V AS +I+ RA +G P + P AGA+ + +
Sbjct: 289 ----SQVKASEKILQVRAASAPAKGTPGKGATPAPPG------KAGAVAS--------QT 330
Query: 1131 DLGSPASKVRFKDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMT 1190
G P +DS E S S++ P SG + + P S
Sbjct: 331 KAGKPE-----EDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKG 385
Query: 1191 ENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDL 1250
P +G ++ G E + + + + K S + P R +P
Sbjct: 386 AAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKE 445
Query: 1251 ENQQQCCF--PTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKE 1308
++ P A + E + S + + S+ E LA + L ++ +
Sbjct: 446 SPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQ 505
Query: 1309 ---------GTEGEG---LQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQL 1356
G G+G + V + G EE + + ++ + A
Sbjct: 506 VKPASTMGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVA 565
Query: 1357 EEIEETGGEGLQEE----------------GVQLEEVKEGPEGGLQGEALEEGLKEEG-- 1398
E++ G LQ + VQ++ K E+ + EE
Sbjct: 566 PAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPA 625
Query: 1399 ------------LPEEGSVHGQELSEASS---PDGKGSQEDDPVQEEEAGRAS--ASAEP 1441
+P+ + + + AS+ P G+Q +AG A+ A + P
Sbjct: 626 AMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP-----RKAGTATSPAGSSP 680
Query: 1442 CPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAE 1501
A GT+ P E S E+D + E ++G + G K G + Q + P +G+
Sbjct: 681 AVAGGTQRPAEDSSSSEESD--SEEEKTGLAVTVGQAKSVGKGL--QVKAASVPVKGSLG 736
Query: 1502 RSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQ 1561
+ ++ VL KT V +++A Q++ + ++ +
Sbjct: 737 QGTA--------------PVLPGKT--------GPTVTQVKAE--KQEDSESSEEESDSE 772
Query: 1562 QDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALT----GELLLQTQQRRHRLRG----- 1612
+ A Q K ++K Q +A P T G+++ Q + R
Sbjct: 773 EAAASPAQ--VKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPP 830
Query: 1613 LRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEE-----AEGEEFCPCEACVRKKV 1667
+RN + L GP S + A++TA +Q G E +E E EA +V
Sbjct: 831 VRNPQ--NSTVLARGPASVPSVGK-AVATAAQAQTGPEEDSGSSEEESDSEEEAETLAQV 887
Query: 1668 SPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAE 1727
P + A P KE+ ++G AA PGK T P++ + + +
Sbjct: 888 KPSGKTHQIRAALAPAKES--------PRKG------AAPTPPGK--TGPSAAQAGKQDD 931
Query: 1728 GGLGPGLSQGPGVDEGEDGEGSQRLNRDK---------DPKLGEA-----EGDAMAQERE 1773
G + DGE + + DP A A A
Sbjct: 932 SG-------SSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
Query: 1774 GKTHNSETSAGSELGEAEQEG-----------------------EGISERGETGGQGSGH 1810
K SE++A S E+E E I+ + G S
Sbjct: 985 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSK 1044
Query: 1811 EDN------------LQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPE----SEGVEAP 1854
E + Q ++A G P S + ++A +P+ + +AP
Sbjct: 1045 ESSRISDGKKQEGPATQVDSAVG--TLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAP 1102
Query: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEAQ---PESEDVETPEAEWEVQPESEGAEAPEA 1911
E+ D++++ + ED E P+ A P ET E + + AP
Sbjct: 1103 ESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQ 1162
Query: 1912 E-----------------KEAQPETESVEALETEGEDEPESEGAEAQEAEEAA------- 1947
+A P+ +S ++ + + + +G + + ++AA
Sbjct: 1163 SLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKT 1222
Query: 1948 --QEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESE-DVEAPE 2004
+EA T P+ +S++ ++ A AL+ + TQ G+ P +E V+A
Sbjct: 1223 GGKEAASGTTPQ----KSRKPKKGAGNPQASTLALQSNI-TQCLLGQPWPLNEAQVQASV 1277
Query: 2005 AEGEMQEAEEEAQPESDGV-EAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEE 2063
+ + E+E + D E+ K +++ G+ + + A E E
Sbjct: 1278 VKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEA 1337
Query: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGI------E 2117
+ E ++G+A + D +E +G+ S+G + E E E QK G
Sbjct: 1338 SVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGAK-DEPEEELQKGMGTVEGGDQS 1396
Query: 2118 APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESE 2162
P+++ E + +S+ + + + E + +++ +D+E +Q + +
Sbjct: 1397 NPKSKKE-KKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQKKKK 1440
Score = 38.1 bits (87), Expect = 0.10
Identities = 107/516 (20%), Positives = 176/516 (34%), Gaps = 72/516 (13%)
Query: 455 PASSTG---LPEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAG 511
PAS+ G L +G+ P P V A+PSAQ+G + S E+ DG
Sbjct: 508 PASTMGMGPLGKGAGP-------VPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDG-- 558
Query: 512 LGGPEQGGRLTPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKA-----RAETSQQ 566
E + P G + ++ +G + G P KA +E+S++
Sbjct: 559 ----EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAG-PVAVQVKAEKPMDNSESSEE 613
Query: 567 EASEGGDPASPALSLSSLRSDDLQ-AETQGQGTEQATGAAVTREPLVLGL----SCSWDS 621
+ +PA ++ L+ +T+ + T A+ P+ +G +
Sbjct: 614 SSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT 673
Query: 622 EGASSTPSTCTSSQQGQRRHRSRASAMSSPSSPGLGRVAPRGHPRHSHYR-KDTHSPLDS 680
A S+P+ +Q+ S + S GL + + K P+
Sbjct: 674 SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKG 733
Query: 681 SVTKQVPRPPERRRACQDGSVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATV 740
S+ + G+ P G + T TQ + S S D + A
Sbjct: 734 SLGQ--------------GTAPVLPGKTGPTVTQVKAEKQEDSESSEEESD---SEEAAA 776
Query: 741 TPAVHSDFVSGVSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTP 800
+PA V P+A A A +P + T+ + +K + S + P
Sbjct: 777 SPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVV--TAAAQAKQRSPSKVKPPVRNP 834
Query: 801 QPSSPLVLQVGRPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGR 860
Q S+ VL G +VG A +AQ GP E S +
Sbjct: 835 QNST--VLARGPASVPSVG---------KAVATAAQAQTGPE-EDSGSSEEESDSEEEAE 882
Query: 861 PCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSR 920
Q + S G +HQ A +P + + + G P+P +G S + Q
Sbjct: 883 TLAQVKPS-----GKTHQIRA---ALAPAKESPRKGAAPTPPGKTGPSAAQAGKQ--DDS 932
Query: 921 GLSEEKTLRSGGGPQGQEEASGVSPSSL---PRSSP 953
G S E++ G P A + P + P SP
Sbjct: 933 GSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSP 968
Score = 33.5 bits (75), Expect = 2.6
Identities = 70/279 (25%), Positives = 100/279 (35%), Gaps = 68/279 (24%)
Query: 2133 EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA--QPELEGVEAPEAEGEAQ 2190
E E G+ ++ V D Q SE ++AEE+A Q + V P + E+
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 2191 PESEGIEAPEAEGEAQPELE-------GVEAPEAEEE--------------AQPEPEGVE 2229
E E EA A +A P L G + P + +E + P P +
Sbjct: 89 EEEEEAEAETA--KATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGK 146
Query: 2230 T-----------PEAEGEAQPESEGETQGE----------KKGSPQVSLGDGQSEEASES 2268
T AE A ET+ E K G D SE+ S S
Sbjct: 147 TVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS 206
Query: 2269 SSPVP-EDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPD 2327
S E +P+ P+ Q S S A +K + +GD +P
Sbjct: 207 SDETDVEGKPSVKPA-------QVKASSVSTKESPA-------RKAAPAPGKVGDV-TPQ 251
Query: 2328 AKSTGTPHAERKATRMYPESSTSE-----QEEAPLGSRT 2361
K P A+R A + ES +SE +EEAP G+R+
Sbjct: 252 VKGGALPPAKR-AKKPEEESESSEEGSESEEEAPAGTRS 289
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c [Homo
sapiens]
Length = 958
Score = 97.1 bits (240), Expect = 2e-19
Identities = 148/735 (20%), Positives = 260/735 (35%), Gaps = 121/735 (16%)
Query: 1666 KVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQG 1725
KV ++P+ GA P K A ++ + E+ E AP T + ++ +
Sbjct: 244 KVGDVTPQVKGGALP-PAKRA---KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQ 299
Query: 1726 AEGGLGPGL-SQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAG 1784
P + G G G+ ++ K G+ E D+ + E ET A
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTK---AGKPEEDSESSSEESSDSEEETPAA 356
Query: 1785 SEL------GEAEQEGEGISERGETGGQGS-----GHEDNLQGEAAAGGDQDPGQSDGAE 1833
L G+ Q G + E+ +G+ G +A AG ++ QS E
Sbjct: 357 KALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEE 416
Query: 1834 GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETP 1893
EA +A+P + + A A+E+ + AP + P + V+
Sbjct: 417 SDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGA-------APAPPRKTGPAAAQVQVG 469
Query: 1894 EAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQ 1953
+ E + + SE +++ + E A V+ L + +P S + A G+
Sbjct: 470 KQEEDSRSSSEESDS-DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGK 528
Query: 1954 TQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAE 2013
P + + + EE+++ SE+ +S D E P A QE
Sbjct: 529 VGPATPSAQVGKWEEDSESSSEE-----------------SSDSSDGEVPTAVAPAQEKS 571
Query: 2014 E----EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES----DGVEAPEAEEEAQ 2065
+A+P S + P+ G A +V+ E ++ ES D EAP A AQ
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQ 631
Query: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125
A+ ++ + +A P+ + A + P G +AP G A G G
Sbjct: 632 -AKPALKIPQTKACPKKTNTTAS---AKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 2126 QPESEGIEAPEAEGEAQ---------------------------------------PESE 2146
+P + + E++ E + P
Sbjct: 688 RPAEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKT 747
Query: 2147 GVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQ 2206
G + E Q +SE E + EEA V+ + +A+ AP A+G
Sbjct: 748 GPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTIS 807
Query: 2207 PELEGVEAPEAEEEAQPEPEGVETPE---------AEGEAQPESEGE---TQGEKKGSPQ 2254
+ V A A + Q P V+ P A G A S G+ T + + P+
Sbjct: 808 APGKVVTA--AAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPE 865
Query: 2255 VSLGDGQSE-EASESSSPVPEDRPTPPP-------SPGGDTPHQ----RPGSQTGPSSSR 2302
G + E ++ E + + + +P+ +P ++P + P +TGPS+++
Sbjct: 866 EDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQ 925
Query: 2303 ASSWGNCWQKDSEND 2317
A + E+D
Sbjct: 926 AGKQDDSGSSSEESD 940
Score = 84.7 bits (208), Expect = 1e-15
Identities = 133/677 (19%), Positives = 254/677 (37%), Gaps = 48/677 (7%)
Query: 1744 EDGEGSQRLNRDKDP----KLGEAEGDAMAQEREGKTHNSETSA---GSELGEAEQEGEG 1796
ED + R DP + E E +A A+ + + T++ G++L + +E +
Sbjct: 67 EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSMKE-KA 125
Query: 1797 ISERGETGGQGSGHEDNLQGEAAAG--GDQDPGQS--DGAEGIEAPEAEGEAQPESEGVE 1852
+E + G G+ G+ A + P +S A E E E + G
Sbjct: 126 KAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAA 185
Query: 1853 APEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAE 1912
A A +A+ ++ S + + EG+ + V+ + P + A AP
Sbjct: 186 AKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKV 245
Query: 1913 KEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQP 1972
+ P+ + + +PE E ++E E+ +EA T+ + +++ E + +
Sbjct: 246 GDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ---VKASEKILQVRA 302
Query: 1973 ESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGE 2032
S + + T G+A + +A + E + + + EE+ SD E P ++
Sbjct: 303 ASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEES---SDSEEETPAAKAL 359
Query: 2033 EAQEVEGETQKTEGDAQPESD-----GVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDA 2087
+ G+T + + P + AP + A+ + + E ++ SE+ D+
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDS 419
Query: 2088 -QEAEGEAQPESEG--VEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPE 2144
+EA +A+P + V A A + +G AP + P + ++ + E +++
Sbjct: 420 EEEAPAQAKPSGKAPQVRAASAPAKESPRKG-AAPAPPRKTGPAAAQVQVGKQEEDSRSS 478
Query: 2145 SEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGE 2204
SE ++ D E A + ++ + +P P +G A P G P A
Sbjct: 479 SEESDS-DREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKG-AGPVPPGKVGP-ATPS 535
Query: 2205 AQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGE------TQGEKKGSPQVSLG 2258
AQ ++ + EE+ +G E P A AQ +S G T KG PQ +
Sbjct: 536 AQVGKWEEDSESSSEESSDSSDG-EVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKA-- 592
Query: 2259 DGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDH 2318
G ++ P+ + S D+ + P + T + A + +
Sbjct: 593 -GPVAVQVKAEKPMDNSESSEESSDSADS-EEAPAAMTAAQAKPALKIPQTKACPKKTNT 650
Query: 2319 VLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQAL 2378
+P T P AT S G++ P + +S + ++
Sbjct: 651 TASAKVAPVRVGTQAPRKAGTAT-----SPAGSSPAVAGGTQRPAEDSSSSEESDSEEEK 705
Query: 2379 GSLAPTEAVGRADGFGQ 2395
LA T VG+A G+
Sbjct: 706 TGLAVT--VGQAKSVGK 720
Score = 80.5 bits (197), Expect = 2e-14
Identities = 95/451 (21%), Positives = 175/451 (38%), Gaps = 33/451 (7%)
Query: 1935 SEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQ 1994
SE ++AEE A +T+ + S+ +EEE + E+E +A T + A
Sbjct: 57 SELGRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGA- 115
Query: 1995 PESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDG 2054
+ P + E +AE E ++ P + A + G++ + A+P ++
Sbjct: 116 ------DLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRK--SAEPSANT 167
Query: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGE-AQKA 2113
E EE EG V A P V A +A+ ++ S + + EG+ + K
Sbjct: 168 TLVSETEE-----EGSVPAFGAAAKPGM--VSAGQADSSSEDTSSSSDETDVEGKPSVKP 220
Query: 2114 EGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA 2173
++A + P + AP G+ P+ +G A+ +PE E++ +EE +
Sbjct: 221 AQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEE---ESESSEEGS 277
Query: 2174 QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEA 2233
+ E E ++ +A + + A A + P AP + A PE
Sbjct: 278 ESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEE 337
Query: 2234 EGEAQPESEGETQGEKKGSPQV--SLGDGQSEEASESSSPVPED-RPTPPPSPGGDTPHQ 2290
+ E+ E +++ E + + + G++ + +S+P E R P+P G
Sbjct: 338 DSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPG----- 392
Query: 2291 RPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSP-DAKSTGTPHAERKATRMYPESST 2349
+TGP+ ++A + S ++ + +P AK +G R A+ ES
Sbjct: 393 ----KTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPR 448
Query: 2350 SEQEEAPLGSRTPEQGASEGYDLQEDQALGS 2380
AP P + +ED S
Sbjct: 449 KGAAPAPPRKTGPAAAQVQVGKQEEDSRSSS 479
Score = 79.3 bits (194), Expect = 4e-14
Identities = 117/546 (21%), Positives = 200/546 (36%), Gaps = 87/546 (15%)
Query: 1881 GEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA------LETEGEDEPE 1934
G + ED + V +E+ E E+EA+ ET G D P
Sbjct: 60 GRKRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPS 119
Query: 1935 SEGAEAQ-EAEEAAQEAEGQTQPE-----SEVIESQEAEEEAQPESEDVEALEVEVE--- 1985
S +A+ E E+A + P + ++ + + A+P + E E E
Sbjct: 120 SMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSV 179
Query: 1986 ---------TQEAEGEAQPESEDV--EAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEA 2034
+ G+A SED + E + E + + + AQ ++ V + +S +A
Sbjct: 180 PAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK-ESPARKA 238
Query: 2035 QEVEGE----TQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE------- 2083
G+ T + +G A P + + PE E E+ E EG E E A S+
Sbjct: 239 APAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSE-EGSESEEEAPAGTRSQVKASEKI 297
Query: 2084 -DVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQ 2142
V A A + P AP + G A +T+ +PE + + E +++
Sbjct: 298 LQVRAASAPAKGTPGKGATPAPPGKA------GAVASQTKA-GKPEEDSESSSEESSDSE 350
Query: 2143 PESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAE 2202
E+ +A + +A ++ + A A + P AP G+ P +A + E
Sbjct: 351 EETPAAKAL-LQAKASGKTSQVGAASAPAKESPRKGAAPAP--PGKTGPAVAKAQAGKRE 407
Query: 2203 GEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSP--------Q 2254
++Q E ++ E E AQ +P G + P+ + P E +G P Q
Sbjct: 408 EDSQSSSEESDS-EEEAPAQAKPSG-KAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQ 465
Query: 2255 VSLGDGQSEEASESSSPVPEDRP------TPPPSPGGDTPHQRPGS-------------- 2294
V +G Q E++ SS DR P G +P +P S
Sbjct: 466 VQVGK-QEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPASTMGMGPLGKGAGPV 524
Query: 2295 ---QTGPSSSRASSWGNCWQKDSE-NDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTS 2350
+ GP++ A W++DSE + D+ + + P E+ + TS
Sbjct: 525 PPGKVGPATPSAQV--GKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTS 582
Query: 2351 EQEEAP 2356
+ P
Sbjct: 583 SPAKGP 588
Score = 72.8 bits (177), Expect = 4e-12
Identities = 170/841 (20%), Positives = 303/841 (36%), Gaps = 124/841 (14%)
Query: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
G A + G+ G + S S+ + +GK S V+ + +S S + PA
Sbjct: 183 GAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPS-----VKPAQVKASSVSTKESPAR- 236
Query: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPG--LEKPPGATMMGQEHTQAQPTQGAAERSS 1504
+ P + + P G L P +KP + +E ++++ A RS
Sbjct: 237 --KAAPAPGKVGDVTPQVK----GGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ 290
Query: 1505 SVACSAALDCDPIWVSVLLKKTEKAFLAH--LASAVA-ELRARWGLQDNDLLDQMAAELQ 1561
A L + A A A AVA + +A +D++ + +++ +
Sbjct: 291 VKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSE 350
Query: 1562 QDV--AQRLQDSTKRELQKLQGRAGRMVLEPPREAL-------TGELLLQTQQRRHRLRG 1612
++ A+ L + G A E PR+ TG + + Q +
Sbjct: 351 EETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKRE--- 407
Query: 1613 LRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSP 1672
E + S + E+ PA + G A P + RK +P P
Sbjct: 408 --------EDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS---APAKESPRKGAAPAPP 456
Query: 1673 KATMGATRGPIKEAFDL--QQILQRKRGEHTDGE--------AAEVAP-GKT-HTDPTST 1720
+ T GP + Q+ R E +D + AA+V P GK+ P ST
Sbjct: 457 RKT-----GPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKPAST 511
Query: 1721 RTVQGAEGGLGPGLSQGPG-VDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNS 1779
G+GP L +G G V G+ G + ++G+ E D+ + E + +S
Sbjct: 512 M-------GMGP-LGKGAGPVPPGKVGPATP------SAQVGKWEEDSESSSEES-SDSS 556
Query: 1780 ETSAGSELGEAEQEGEG-ISERGETGGQGSGHEDNLQGEAAAGGDQDP--------GQSD 1830
+ + + A+++ G I + T G A + P SD
Sbjct: 557 DGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSD 616
Query: 1831 GAEGIEAPEAEGEAQPESEGVEAPEAEGDAQE----AEGEAQPESEDVEAPEAEGEAQPE 1886
A+ EAP A AQ + ++ P+ + ++ A + P +AP G A
Sbjct: 617 SADSEEAPAAMTAAQAKP-ALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTAT-- 673
Query: 1887 SEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEA 1946
S +P Q +E + + E E+ E E T G+ + +G + + A
Sbjct: 674 SPAGSSPAVAGGTQRPAEDSSSSE---ESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVP 730
Query: 1947 AQEAEGQ--------------TQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGE 1992
+ + GQ TQ ++E E E+ EE + +SE+ A +V+T + +
Sbjct: 731 VKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEE-ESDSEEAAASPAQVKTSVKKTQ 789
Query: 1993 AQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES 2052
A+ AP A+G + + + + P + + T G A S
Sbjct: 790 AKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Query: 2053 DGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQK 2112
G A A+ + PE ED + E E +++ E+E + + G+ +
Sbjct: 850 VGKAVATA-------------AQAQTGPE-EDSGSSEEESDSEEEAETLAQVKPSGKTHQ 895
Query: 2113 AEGIEAPETEGE---AQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEA 2169
AP E A P G P A + + G +++++ + + + AQ+
Sbjct: 896 IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQ 955
Query: 2170 E 2170
E
Sbjct: 956 E 956
Score = 65.9 bits (159), Expect = 5e-10
Identities = 175/875 (20%), Positives = 298/875 (34%), Gaps = 152/875 (17%)
Query: 1270 ATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGL-QEEAVQLEETKTE 1328
+++ DE + + + + ++ + +T + + G G+ Q + L K
Sbjct: 204 SSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRA 263
Query: 1329 EGLQEEGVQLEETKETEGEGQQEEEAQL---EEIEETGGEGLQEEGVQLEEVKEGPEGGL 1385
+ +EE EE E+E E +Q+ E+I + +G + P G
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 1386 QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDP-----VQEEEAGRAS-ASA 1439
A + + G PEE S E+SS + S+E+ P +Q + +G+ S A
Sbjct: 324 GAVASQT---KAGKPEEDS-------ESSSEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Query: 1440 EPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGA 1499
PA+ + P+ +T P+ ++ Q+G + E +Q +
Sbjct: 374 ASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREE--------------------DSQSS 413
Query: 1500 AERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAE 1559
+E S S + A K + KA ASA A+ R G A
Sbjct: 414 SEESDSEEEAPA----------QAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAA 463
Query: 1560 LQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAF 1619
Q V ++ +DS R+ + REAL Q + ++
Sbjct: 464 AQVQVGKQEEDS----------RSSSEESDSDREALAAMNAAQVKPLG------KSPQVK 507
Query: 1620 SERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGAT 1679
T+G+GP LG G G KV P +P A +G
Sbjct: 508 PASTMGMGP--------------LGKGAGPVPPG------------KVGPATPSAQVGKW 541
Query: 1680 RGPIKEAFDLQQILQRKRGEHTDGEA-AEVAPGK-------THTDPTSTRTVQGAEGGLG 1731
+ + + + +DGE VAP + PTS+ +G G
Sbjct: 542 EEDSESS-------SEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSS-PAKGPPQKAG 593
Query: 1732 PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE 1791
P Q ++ E S+ + D + EA A + + +T A +
Sbjct: 594 PVAVQVKAEKPMDNSESSEESSDSADSE--EAPAAMTAAQAKPALKIPQTKACPKKTNTT 651
Query: 1792 QEGEGISER-GETGGQGSGHEDNLQGE--AAAGGDQDPGQSDGAEGIEAPEAE------- 1841
+ R G + +G + G A AGG Q P + + E E
Sbjct: 652 ASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVT 711
Query: 1842 -GEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQ 1900
G+A+ +G++ A + + G+ AP G+ P V +AE +
Sbjct: 712 VGQAKSVGKGLQVKAASVPVKGSLGQG-------TAPVLPGKTGPTVTQV---KAEKQED 761
Query: 1901 PESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEV 1960
ES E+ E A P +T+ A+A A A A+G +V
Sbjct: 762 SESSEEESDSEEAAASPAQVKTSVKKTQ---------AKANPAAARAPSAKGTISAPGKV 812
Query: 1961 IESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPES 2020
+ + ++ P + T A G A S A A+ + PE
Sbjct: 813 VTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATA------AQAQTGPEE 866
Query: 2021 DGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHP 2080
D ++ +S+ EE E + + + Q + A A + +G G+ P
Sbjct: 867 DSGSSEEESDSEEEAETLAQVKPSGKTHQ-----IRAALAPAKESPRKGAAPTPPGKTGP 921
Query: 2081 ESEDVDAQEAEGEAQPESEG-VEAPEAEGEAQKAE 2114
+ Q+ G + ES+ EAP A AQ E
Sbjct: 922 SAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQDQE 956
Score = 60.1 bits (144), Expect = 3e-08
Identities = 143/661 (21%), Positives = 245/661 (37%), Gaps = 99/661 (14%)
Query: 486 SAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSASTGSHEGS 545
++++G +RKA ED L + P + E ++ ++ S S
Sbjct: 56 TSELGRKRKAE----EDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSS 111
Query: 546 SEWGGRPQGCPGKARAETSQQEASEGGDP--------------ASPALSLSSLRSDDLQA 591
P KA+AET + + P SP S + L +
Sbjct: 112 VLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVS 171
Query: 592 ETQGQGTEQATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQRRHRSRASAMSSP 651
ET+ +G+ A GAA + G + S + +SS+ T + + + +AS++S+
Sbjct: 172 ETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTK 231
Query: 652 SSPGLGRVAPRGHPRHSHYRKDTHSPLDSSV--TKQVPRPPERRRACQDGSVPRYSG-SS 708
SP A + P T ++ K+ +P E + ++GS +
Sbjct: 232 ESP-----ARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAG 286
Query: 709 SSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPSAGWAGDAGS 768
+ ++ +AS + + S P++ GT TPA G AG S
Sbjct: 287 TRSQVKASEKILQVRAASAPAK---GTPGKGATPA---------------PPGKAGAVAS 328
Query: 769 RTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPL-------VLQVGRPEQGA-VGP 820
+T + P DS S S +S EE +TP + L QVG A P
Sbjct: 329 QTKAGKP----EEDSESSSEESSDSEE--ETPAAKALLQAKASGKTSQVGAASAPAKESP 382
Query: 821 HRSHCCSQPG-TQPA-QEAQRGPSPEASWLCGRYCPT----PPRGRP---CPQRRSSSCG 871
+ + PG T PA +AQ G E S + P + +P PQ R++S
Sbjct: 383 RKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP 442
Query: 872 STGSSHQSTA------RGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGS-RGLSE 924
+ S + A GP + + +Q + S S + R + A+ A + L +
Sbjct: 443 AKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPLGK 502
Query: 925 EKTLR----SGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETT 980
++ G GP G + A V P + ++P A V +W ++ E + E +
Sbjct: 503 SPQVKPASTMGMGPLG-KGAGPVPPGKVGPATPSAQVGKWEED---------SESSSEES 552
Query: 981 GAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQQSLEGDPGQDPEPEG---ALLGSSDTGPQ 1037
+ G V P + S LG QA S P + P + A+ ++
Sbjct: 553 SDSSDGEVPTAVAPAQEKS---LGNILQAKPTS---SPAKGPPQKAGPVAVQVKAEKPMD 606
Query: 1038 SGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGR--VSASTQIMRALMGSKQG 1095
+ E + + EAPA A + PA +A P + +AS ++ +G++
Sbjct: 607 NSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAP 666
Query: 1096 R 1096
R
Sbjct: 667 R 667
Score = 33.5 bits (75), Expect = 2.6
Identities = 70/279 (25%), Positives = 100/279 (35%), Gaps = 68/279 (24%)
Query: 2133 EAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA--QPELEGVEAPEAEGEAQ 2190
E E G+ ++ V D Q SE ++AEE+A Q + V P + E+
Sbjct: 29 EVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDPISTSESS 88
Query: 2191 PESEGIEAPEAEGEAQPELE-------GVEAPEAEEE--------------AQPEPEGVE 2229
E E EA A +A P L G + P + +E + P P +
Sbjct: 89 EEEEEAEAETA--KATPRLASTNSSVLGADLPSSMKEKAKAETEKAGKTGNSMPHPATGK 146
Query: 2230 T-----------PEAEGEAQPESEGETQGE----------KKGSPQVSLGDGQSEEASES 2268
T AE A ET+ E K G D SE+ S S
Sbjct: 147 TVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSS 206
Query: 2269 SSPVP-EDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSPD 2327
S E +P+ P+ Q S S A +K + +GD +P
Sbjct: 207 SDETDVEGKPSVKPA-------QVKASSVSTKESPA-------RKAAPAPGKVGDV-TPQ 251
Query: 2328 AKSTGTPHAERKATRMYPESSTSE-----QEEAPLGSRT 2361
K P A+R A + ES +SE +EEAP G+R+
Sbjct: 252 VKGGALPPAKR-AKKPEEESESSEEGSESEEEAPAGTRS 289
>gi|38176300 nestin [Homo sapiens]
Length = 1621
Score = 96.3 bits (238), Expect = 3e-19
Identities = 164/648 (25%), Positives = 244/648 (37%), Gaps = 128/648 (19%)
Query: 1742 EGEDGEGSQRLNRDKDPKLG--EAEGDAMAQEREGKTHNSETSAGSELGEAEQEG-EGIS 1798
E E+ E + L ++ L E E ++ + E + H S S L E +QE +
Sbjct: 704 EDENKEAFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRS----LEEQDQETLRTLE 759
Query: 1799 ERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEG 1858
+ + + G +D + D +P +S E E E + +S E+ EA
Sbjct: 760 KETQQRRRSLGEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVK 819
Query: 1859 DAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAE---WEVQPESEGAEAPEAEKEA 1915
E+E +E+ ++ G Q E +++PE + W + ++GA P EKE
Sbjct: 820 SL---------ETEILESLKSAG--QENLETLKSPETQAPLWTPEEINQGAMNP-LEKEI 867
Query: 1916 QPETESVEA-------LETEGEDEPESEGA----EAQEAEEAAQEAEGQTQPES------ 1958
Q ESVE LE E ++ S GA + EE +E++ + E
Sbjct: 868 QEPLESVEVNQETFRLLEEENQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGE 927
Query: 1959 --EVIESQEAEEEAQPESEDVEALEVEVET-QEAEGEAQPESEDVE-APEAE-------- 2006
E + S E E + P+S DV+ E VE QE E+ P VE EAE
Sbjct: 928 YQESLRSLEEEGQELPQSADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDG 987
Query: 2007 ----------GEMQEAEE-----EAQPESDGVEAQP--------KSEGEEAQEVEGETQK 2043
GE+ EE E PES + Q K E Q+ EG++Q
Sbjct: 988 FTGKEEVVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKGGAEGLQDPEGQSQ- 1046
Query: 2044 TEGDAQPESDGVEAPEAEEEAQE--AEGEVQEAEGEAHPE----SEDVDAQEAEGEAQPE 2097
Q + G++AP+ EA E E +V +A PE SE + A G
Sbjct: 1047 -----QVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEVMLGSEPAMGESAAGAEPGP 1101
Query: 2098 SEGV---------------EAP--EAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGE 2140
+GV E P E EA++ +G+E P + E + G E E G+
Sbjct: 1102 GQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGPRKDLE-EAGGLGTEFSELPGK 1160
Query: 2141 A----QPESEGVEAQDAE-----------------GEAQPESEGIEAQEAEEEAQPELEG 2179
+ +P EG E +AE G P + ++EAEE+ P L
Sbjct: 1161 SRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVS 1220
Query: 2180 VE---APEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236
P E P+ + + EA Q E + E+E+E E E P+ EGE
Sbjct: 1221 PSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGE 1280
Query: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPG 2284
E E + + LG S P E RP P G
Sbjct: 1281 ESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETG 1328
Score = 95.1 bits (235), Expect = 7e-19
Identities = 246/1084 (22%), Positives = 394/1084 (36%), Gaps = 165/1084 (15%)
Query: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEVQLE-ETKEGTEGEGLQEEAVQL-----EETK 1326
E+E E Q + LE+ ++ EE+Q +T E E L+ E + E+ +
Sbjct: 525 EEEDLNRKEIQDSQVPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLE 584
Query: 1327 TEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQ 1386
T + L++E +L + E ++E QL+ + + LQ + +E+ + EG L+
Sbjct: 585 TLKSLEKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLE 644
Query: 1387 GEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446
L G + + L QE E+ + K +QE P++ E G A P
Sbjct: 645 -TFLFPGTENQELVSSL----QENLESLTALEKENQE--PLRSPEVGDEEA-LRPL---- 692
Query: 1447 TEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSV 1506
T+E EP L + + A E P T+ ++ + +P + +S
Sbjct: 693 TKENQEPLRSLEDENKEAFRSLEKENQE------PLKTLEEEDQSIVRPLETENHKSLRS 746
Query: 1507 ACSAALDCDPIWVSVLLKKTEKAFLAHLASAVAELRARWGLQDNDLLD-------QMAAE 1559
L++ ++ L L + R G QD L +
Sbjct: 747 ----------------LEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPPEKVDLEPLKS 790
Query: 1560 LQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAF 1619
L Q++A+ L++ + L+ L+ + V ++L E+L + G NL
Sbjct: 791 LDQEIARPLENENQEFLKSLKEESVEAV-----KSLETEILESLKSA-----GQENLETL 840
Query: 1620 SERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEEFCPCEACVRKKVSPMSPKATMGAT 1679
PL E L ++ E E E + ++ + S ++
Sbjct: 841 KSPETQ-APLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWN 899
Query: 1680 RGPIKEAFDLQQILQRKRGEHTD---GEAAEVAPGKTHTDPTSTRTVQGAEGGLGPGLSQ 1736
++ ++ + QR E + GE E S R+++ G L Q
Sbjct: 900 LENLRSPEEVDKESQRNLEEEENLGKGEYQE-----------SLRSLEEE----GQELPQ 944
Query: 1737 GPGVDEGEDG-EGSQRLNRDKDPKLGEAEGDAMAQ----EREGKTHNSETSAGSELGEAE 1791
V ED E Q L ++ P + E + A+ E++G T E EL E
Sbjct: 945 SADVQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATE 1004
Query: 1792 Q---EGEGISERGETGGQGSGHEDNLQGEAAAGGDQDP-GQSD--GAEGIEAPEAEGEAQ 1845
+ GEG E E Q G + + A G QDP GQS GA G++AP+ EA
Sbjct: 1005 EVWIPGEGHPESPEPKEQ-RGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEA- 1062
Query: 1846 PESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG 1905
+E P E D +A PE P A GE+ +E P G
Sbjct: 1063 -----IE-PLVEDDVAPGGDQASPEVMLGSEP-AMGESAAGAEPGPGQGVGGLGDP---G 1112
Query: 1906 AEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQE 1965
E E E ES+EA +G + P + EA E G+++ E +E
Sbjct: 1113 HLTREEVMEPPLEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWE--PPRE 1170
Query: 1966 AEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPE-----S 2020
EE++ E+ ET G P + + EAE ++ P
Sbjct: 1171 GREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGSEEAEEDVPPVLVSPSPTYTPILE 1230
Query: 2021 DGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHP 2080
D QP++EG +Q+ Q ++ + E+E+E + GE+ E E
Sbjct: 1231 DAPGPQPQAEG---------SQEASWGVQGRAEALGKVESEQE-ELGSGEIPEGPQEEGE 1280
Query: 2081 ESEDVDAQEAEGEAQPESE--GVEAPEAEGEAQKAEGIEAPETEGEAQPE--------SE 2130
ES + ++ GE P+S G G + P +GE E SE
Sbjct: 1281 ESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGKEGWDPAVLASE 1340
Query: 2131 GIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQ 2190
G+EAP +E E E E +D++ + E G EA P L GV AE Q
Sbjct: 1341 GLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEA--------PFLPGVPGEVAEPLGQ 1392
Query: 2191 PESEGIEAP------EAEGEAQPELEGVEAPEAEEEAQPEPEGVETP-EAEGEAQPESEG 2243
++ E++G A E G E E +EE + G P + G Q S
Sbjct: 1393 VPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSS 1452
Query: 2244 E-------------------TQGEKKGSPQVSLGDGQSEEA-----SESSSPVPEDRPTP 2279
+ +G G+P+ +L + A E S PV +R
Sbjct: 1453 QRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDK 1512
Query: 2280 PPSP 2283
P P
Sbjct: 1513 VPGP 1516
Score = 84.0 bits (206), Expect = 2e-15
Identities = 151/580 (26%), Positives = 224/580 (38%), Gaps = 72/580 (12%)
Query: 1707 EVAPGKTHTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDK--DPKLGEAE 1764
+VAPG P + A G G GPG G G+ L R++ +P L E
Sbjct: 1070 DVAPGGDQASPEVMLGSEPAMGESAAGAEPGPGQGVGGLGDPG-HLTREEVMEPPLEEES 1128
Query: 1765 GDA-MAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGD 1823
+A Q EG + E + G LG E G S R G E++ + EA G +
Sbjct: 1129 LEAKRVQGLEGPRKDLEEAGG--LGTEFSELPGKS-RDPWEPPREGREES-EAEAPRGAE 1184
Query: 1824 QD-PGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGE 1882
+ P ++ G G +AP P G E EAE D P P E
Sbjct: 1185 EAFPAETLGHTGSDAP------SPWPLGSE--EAEEDVPPVLVSPSP----TYTPILEDA 1232
Query: 1883 AQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQE 1942
P+ + + EA W VQ +E E+E+E E E + EGE +
Sbjct: 1233 PGPQPQAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGE----------ES 1282
Query: 1943 AEEAAQEAEGQTQPESEVIE---SQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESED 1999
EE+ ++ G+T P+S + P E + E +E A SE
Sbjct: 1283 REESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQRPPPQGET-GKEGWDPAVLASEG 1341
Query: 2000 VEAPEAEGEM-QEAEEEAQPESD--------GVEAQ--PKSEGEEAQEVEGETQKTEGDA 2048
+EAP +E E +E EEE +SD G EA P GE A+ + Q A
Sbjct: 1342 LEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPA 1401
Query: 2049 QPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEG 2108
+ DG A+EE EGE + EG + G P S V + +A
Sbjct: 1402 AWDRDGESDGFADEEESGEEGEEDQEEGR----------EPGAGRWGPGS-SVGSLQALS 1450
Query: 2109 EAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQE 2168
+Q+ E +E+ ++ + P + + A A + E+QD+ A+P E+
Sbjct: 1451 SSQRGEFLES-DSVSVSVPWDDSLRG--AVAGAPKTALETESQDS---AEPSGSEEESDP 1504
Query: 2169 AEEEAQPELEG-VEAPEAEGEAQPESEGI----EAPEAEGEAQPELEGV--EAPEAEEEA 2221
E + ++ G +E P +A P ++ I + P EG++Q GV ++EE
Sbjct: 1505 VSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVG 1564
Query: 2222 QPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQ 2261
Q P + + G E EG V LG GQ
Sbjct: 1565 QGMP--LVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQ 1602
Score = 72.8 bits (177), Expect = 4e-12
Identities = 136/535 (25%), Positives = 200/535 (37%), Gaps = 84/535 (15%)
Query: 1828 QSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQ--P 1885
+ + E ++ E + E+ G P + D Q + + E +++ E E P
Sbjct: 590 EKENKELLKDVEVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFP 649
Query: 1886 ESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALE--TEGEDEP----ESEGAE 1939
+E+ E + E E E PE EAL T+ EP E E E
Sbjct: 650 GTENQELVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKE 709
Query: 1940 A-----QEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALE-VEVETQEAE--- 1990
A +E +E + E + Q +E++ + E +D E L +E ETQ+
Sbjct: 710 AFRSLEKENQEPLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSL 769
Query: 1991 GEAQ------PESEDVE---------APEAEGEMQEAEEEAQPESDGVEA---------- 2025
GE PE D+E A E E QE + + ES VEA
Sbjct: 770 GEQDQMTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEES--VEAVKSLETEILE 827
Query: 2026 QPKSEGEEAQEV--EGETQKTEGDAQPESDGVEAPEAEE-----EAQEAEGEVQEAEGEA 2078
KS G+E E ETQ + + G P +E E+ E E E
Sbjct: 828 SLKSAGQENLETLKSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEE 887
Query: 2079 HPES-EDVDAQEAEGEAQPE------SEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEG 2131
+ ES + A E PE +E E G+ + E + + E EG+ P+S
Sbjct: 888 NQESLRSLGAWNLENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSAD 947
Query: 2132 IEA--------PEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAP 2183
++ E E+ P GVE +D E +G +E E Q EL E
Sbjct: 948 VQRWEDTVEKDQELAQESPPGMAGVENEDEAELNLREQDGFTGKE-EVVEQGELNATEEV 1006
Query: 2184 EAEGEAQPESEG-------IEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGE 2236
GE PES +E +G A EG++ PE + + P G++ P+ E
Sbjct: 1007 WIPGEGHPESPEPKEQRGLVEGASVKGGA----EGLQDPEGQSQQVGAP-GLQAPQGLPE 1061
Query: 2237 A-QPESEGE-TQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPH 2289
A +P E + G + SP+V LG SE A S+ E P GD H
Sbjct: 1062 AIEPLVEDDVAPGGDQASPEVMLG---SEPAMGESAAGAEPGPGQGVGGLGDPGH 1113
Score = 53.5 bits (127), Expect = 2e-06
Identities = 98/434 (22%), Positives = 162/434 (37%), Gaps = 61/434 (14%)
Query: 1836 EAPE---AEGEAQPESEGVEAPEAEG-DAQEAEGEAQPESEDVEAPEAEGEAQPESEDVE 1891
+APE AE + + PE G QEA PE AP P+ +E
Sbjct: 423 QAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLS----PDHSSLE 478
Query: 1892 TPEAEWE-------VQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
+ E + E EG EKE E + V +L+ E +E + E Q+++
Sbjct: 479 AKDGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQ 538
Query: 1945 -----EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET-QEAEGEAQPESE 1998
E + + Q + +E+Q E + E +LE ++ET + E E + +
Sbjct: 539 VPLEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLK 598
Query: 1999 DVEA-----PEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEG----------ETQK 2043
DVE EA G+++ +E ++ +++ K E + +EG E Q+
Sbjct: 599 DVEVVRPLEKEAVGQLKPTGKE---DTQTLQSLQKENQELMKSLEGNLETFLFPGTENQE 655
Query: 2044 TEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEG------EAHPESEDVDAQEAEGEAQPE 2097
Q + + A E E + EV + E E ++ + E E
Sbjct: 656 LVSSLQENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLE 715
Query: 2098 SEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEA----EGEAQPESEGVEAQDA 2153
E E P E + + ETE S + E E E Q + QD
Sbjct: 716 KENQE-PLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQ 774
Query: 2154 EGEAQPESEGIE---------AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGE 2204
PE +E A+ E E Q L+ ++ E E+E +E+ ++ G
Sbjct: 775 MTLRPPEKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAG- 833
Query: 2205 AQPELEGVEAPEAE 2218
Q LE +++PE +
Sbjct: 834 -QENLETLKSPETQ 846
Score = 50.4 bits (119), Expect = 2e-05
Identities = 173/769 (22%), Positives = 269/769 (34%), Gaps = 179/769 (23%)
Query: 1222 TLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSE 1281
+L +G ELP QR + T E +L + + A NEDEAE +
Sbjct: 934 SLEEEGQELPQSADVQRWED-TVEKDQELAQE---------SPPGMAGVENEDEAELNLR 983
Query: 1282 EQRASSNLEQLAENTVQEEVQLEETKE-GTEGEGLQEEAVQLEETKTEEGLQEEGVQLEE 1340
EQ + E+ V E+ +L T+E GEG E E+ EG +G
Sbjct: 984 EQDGFTGKEE-----VVEQGELNATEEVWIPGEGHPESPEPKEQRGLVEGASVKG----- 1033
Query: 1341 TKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLP 1400
EG Q+ E Q +++ G GLQ P+G EA+E L E+ +
Sbjct: 1034 ----GAEGLQDPEGQSQQV---GAPGLQ-----------APQG--LPEAIEP-LVEDDVA 1072
Query: 1401 EEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGT-----------EE 1449
G E+ S P G ++A AEP P +G EE
Sbjct: 1073 PGGDQASPEVMLGSEP--------------AMGESAAGAEPGPGQGVGGLGDPGHLTREE 1118
Query: 1450 PTEPPSHLSETDPSASERQSGSQLEPGLEKPPG-----ATMMGQEHTQAQPTQGAAERSS 1504
EPP L E A Q LE+ G + + G+ +P + E S
Sbjct: 1119 VMEPP--LEEESLEAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESE 1176
Query: 1505 SVACSAALDCDPIWVSVLLKKTEKAFLAH-LASAVAELRARWGLQDNDLLDQMAAELQQD 1563
+ A A E+AF A L ++ + W L + E ++D
Sbjct: 1177 AEAPRGA---------------EEAFPAETLGHTGSDAPSPWPLG--------SEEAEED 1213
Query: 1564 VAQRLQDSTKRELQKLQGRAGRMVLEPPREALTGELLLQTQQRRHRLRGLRNLSAFSERT 1623
V L + L+ G P+ + E Q R L + + +
Sbjct: 1214 VPPVLVSPSPTYTPILEDAPG----PQPQAEGSQEASWGVQGRAEALGKVES----EQEE 1265
Query: 1624 LGLGPLSFTLEDEPALSTALGSQLGEEAEGEEF-------CPCEACVRKKVSPMSPK-AT 1675
LG G + ++E G + EE+E +E P +R SP SP+
Sbjct: 1266 LGSGEIPEGPQEE-------GEESREESEEDELGETLPDSTPLGFYLR---SPTSPRWDP 1315
Query: 1676 MGATRGPI-----KEAFD----LQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGA 1726
G R P KE +D + L+ E +GE E G+ +D + G
Sbjct: 1316 TGEQRPPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGR-DSDLSEEFEDLGT 1374
Query: 1727 EGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSE 1786
E PG+ PG G+ Q L D A +R+G
Sbjct: 1375 EAPFLPGV---PGEVAEPLGQVPQLLL------------DPAAWDRDG------------ 1407
Query: 1787 LGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQP 1846
E +G ++ E+G + G ED +G G PG S G+ + GE
Sbjct: 1408 ------ESDGFADEEESGEE--GEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFL- 1458
Query: 1847 ESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEG- 1905
ES+ V D+ P++ E++ A+P + E+ E + + G
Sbjct: 1459 ESDSVSVSVPWDDSLRGAVAGAPKT--ALETESQDSAEPSGSEEESDPVSLEREDKVPGP 1516
Query: 1906 AEAPEAEKEAQPETESV----EALETEGEDEPESEGA--EAQEAEEAAQ 1948
E P ++A P + + + EG+ + + G +++EE Q
Sbjct: 1517 LEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQSEEVGQ 1565
Score = 45.8 bits (107), Expect = 5e-04
Identities = 152/660 (23%), Positives = 239/660 (36%), Gaps = 132/660 (20%)
Query: 920 RGLSEEKTLRSGGGPQGQEEASGVSPSS--LPRSSPEAVVREWLDNIPEEPILMTYELAD 977
R L EE+ L G + QE + LP+S A V+ W D + ++ ELA
Sbjct: 915 RNLEEEENLGKG---EYQESLRSLEEEGQELPQS---ADVQRWEDTVEKDQ-----ELAQ 963
Query: 978 ETTGAAGGGLRGPEVDPG--DDHSLEGLGEPAQAGQQSL--------EGDPGQDPEP--- 1024
E+ G E + + G E + G+ + EG P + PEP
Sbjct: 964 ESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHP-ESPEPKEQ 1022
Query: 1025 ----EGALLGSSDTGPQSGEGVPQ--GA----APEGVSEAPAEAGADREAPAGCRVSLRA 1074
EGA + G Q EG Q GA AP+G+ EA D AP G + S
Sbjct: 1023 RGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASPEV 1082
Query: 1075 LPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGS 1134
+ G A + + G++ G V + P +T ++ E+
Sbjct: 1083 MLGSEPAMGE---SAAGAEPGPGQGVGGLGDP----------GHLTREEVMEPPLEEESL 1129
Query: 1135 PASKVRFKDSPR------------YQELLSISKDLW----PGCDVGEDQLDSGLWELTWS 1178
A +V+ + PR + EL S+D W G + E + G E +
Sbjct: 1130 EAKRVQGLEGPRKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPA 1189
Query: 1179 QALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQR 1238
+ L GS A + P S E VP + T L Q
Sbjct: 1190 ETLGHTGSDAPSP--WPLGSE----------EAEEDVPPVLVSPSPTYTPILEDAPGPQP 1237
Query: 1239 PDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQ 1298
+ E+ ++ + + + + + EE R S ++L E T+
Sbjct: 1238 QAEGSQEASWGVQGRAEALGKVESEQEELGSGEIPEGPQEEGEESREESEEDELGE-TLP 1296
Query: 1299 EEVQL-----EETKEGTEGEGLQEEAVQLEETKTEEG-----LQEEGVQLEETKETEGEG 1348
+ L T + G Q Q E K EG L EG++ +++ EGE
Sbjct: 1297 DSTPLGFYLRSPTSPRWDPTGEQRPPPQGETGK--EGWDPAVLASEGLEAPPSEKEEGEE 1354
Query: 1349 QQEE---EAQL-EEIEETGGEGLQEEGV---------QLEEVKEGP-----EGGLQGEAL 1390
+EE ++ L EE E+ G E GV Q+ ++ P +G G A
Sbjct: 1355 GEEECGRDSDLSEEFEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFAD 1414
Query: 1391 EEGLKEEGLPEE-------------GSVHGQELSEASSPDGKGSQEDD---PVQEEEAGR 1434
EE EEG ++ GS G + +SS G+ + D V +++ R
Sbjct: 1415 EEESGEEGEEDQEEGREPGAGRWGPGSSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLR 1474
Query: 1435 ASASAEPCPAEGTE--EPTEPPSHLSETDPSASERQ----SGSQLEPGLEKP-PGATMMG 1487
+ + P A TE + EP E+DP + ER+ ++ G+E PGA ++G
Sbjct: 1475 GAVAGAPKTALETESQDSAEPSGSEEESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIG 1534
Score = 37.7 bits (86), Expect = 0.14
Identities = 86/344 (25%), Positives = 129/344 (37%), Gaps = 67/344 (19%)
Query: 1221 GTLVTQGTELPLKTSN--QRPDSRTYESPGDLENQQQCCFPTFLNARACACATN-----E 1273
G L T+ +ELP K+ + + P ES + + FP + A +
Sbjct: 1148 GGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAPSPWPLGS 1207
Query: 1274 DEAERDSEEQRASSN--LEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGL 1331
+EAE D S + + E+ + Q E ++E + G + EA+ E++ EE
Sbjct: 1208 EEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVESEQEE-- 1265
Query: 1332 QEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEE---GVQLEEVKE---GPEGGL 1385
L + EG ++ EE++ E E+ GE L + G L P G
Sbjct: 1266 ------LGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQ 1319
Query: 1386 ----QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEP 1441
QGE +EG L EG + P K E+ EEE GR S +E
Sbjct: 1320 RPPPQGETGKEGWDPAVLASEGL--------EAPPSEKEEGEEG---EEECGRDSDLSEE 1368
Query: 1442 CPAEGTEEPTEP--PSHLS--------------------ETDPSASERQSGSQLEPGLE- 1478
GTE P P P ++ E+D A E +SG + E E
Sbjct: 1369 FEDLGTEAPFLPGVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEE 1428
Query: 1479 -KPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSV 1521
+ PGA G + G+ + SS L+ D + VSV
Sbjct: 1429 GREPGAGRWG-----PGSSVGSLQALSSSQRGEFLESDSVSVSV 1467
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 94.0 bits (232), Expect = 2e-18
Identities = 100/477 (20%), Positives = 196/477 (41%), Gaps = 34/477 (7%)
Query: 1773 EGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGA 1832
+G+ +E +GS+ G E+ E + E G H + + + + +S+
Sbjct: 28 DGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEEL 87
Query: 1833 EGIEAPEAEGEAQPE-----SEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQP-E 1886
+ ++E E + E SE + + D++ E P S+ G A E
Sbjct: 88 HRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSE 147
Query: 1887 SEDV-ETPEAEWEVQP-ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAE 1944
+EDV + P ++ E++ + A E E +P+ E+ E +SE E +
Sbjct: 148 NEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPR 207
Query: 1945 EAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPE 2004
+ E+E +P+ ES+E +SE+ E + + E+E + ++ D E E
Sbjct: 208 MSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEE 267
Query: 2005 -AEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEE 2063
+ + ++E E P + + SE EE + ++EG + + E +A
Sbjct: 268 LPKPRISDSESEDPPRNQASD----SENEELPKPRVSDSESEGPQKGPASDSETEDASRH 323
Query: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEG 2123
Q+ E + +++ E E ++ ++ + + + ++E E K + +++ E E
Sbjct: 324 KQKPESD-DDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEK 382
Query: 2124 EAQPESEG------IEAPEAEGEAQPESEGV--EAQDAEGEAQPESEGIE----AQEAEE 2171
E + E + E E +A + V +A D++ +A + G A ++EE
Sbjct: 383 EGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEE 442
Query: 2172 EAQPELEGVEAPE-----AEGEAQPESEGIEAP---EAEGEAQPELEGVEAPEAEEE 2220
EA EL + E ++ E+ E E + A E+ E + E G + EEE
Sbjct: 443 EAGKELSDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEE 499
Score = 93.6 bits (231), Expect = 2e-18
Identities = 118/526 (22%), Positives = 227/526 (43%), Gaps = 60/526 (11%)
Query: 1693 LQRKRGEHTDGEAAEVAPGKTHTDPTST-RTVQGAEGGLGPGLSQGPGVDEGEDGEG--- 1748
+Q +R +DGE +V + +D S R + GL +G V + E+ E
Sbjct: 19 VQDERDSGSDGED-DVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNL 77
Query: 1749 ------SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGE 1802
S+ L+R KD ++E + A+ + N + + E+E E +
Sbjct: 78 NASDSESEELHRQKD---SDSESEERAEPPASDSENEDVNQHGSDSESE-------ETRK 127
Query: 1803 TGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEG-IEAPEAEGEAQPESEGVEAPE-AEGDA 1860
G S +E+ L G A+ ++D G+ ++ IE + + E+E P+ ++ ++
Sbjct: 128 LPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSES 187
Query: 1861 QEAEGEAQPESEDVEAP-----EAEGEA--QPESEDVETPEAEWEVQPESEGAEAP---- 1909
+E +SE+ E P ++E E +P+ D E+ E +SE E P
Sbjct: 188 EEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRI 247
Query: 1910 -EAEKEAQPETESVEALETEGEDEPESEGAEAQE-AEEAAQEAEGQTQPESEVIESQEAE 1967
++E E P ++ ++ E E +P +E+++ A ++E + P+ V +S+
Sbjct: 248 SDSESEDPPRHQASDS-ENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEG 306
Query: 1968 EEAQPESEDVEALEVEVETQEAEGEAQ-PESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ 2026
+ P S+ ET++A Q PES+D E +GE E + ++ SD +
Sbjct: 307 PQKGPASDS--------ETEDASRHKQKPESDDDSDRENKGEDTEMQNDSF-HSDSHMDR 357
Query: 2027 PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVD 2086
K +++E E + QK + D + E +G E A+ +A E + A D
Sbjct: 358 KKFHSSDSEEEEHKKQKMDSD-EDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSD 416
Query: 2087 AQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESE 2146
A +++ +A + G ++++ G E + + E + + ++ E+ E E
Sbjct: 417 ADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEK------DLFGSDSESGNEEE 470
Query: 2147 GVEAQDAEGEAQPESE----GIEAQEAEEEAQPELEGVEAPEAEGE 2188
+ A D GE+ E E G ++ EEE + E + EA +++ +
Sbjct: 471 NLIA-DIFGESGDEEEEEFTGFNQEDLEEE-KGETQVKEAEDSDSD 514
Score = 84.0 bits (206), Expect = 2e-15
Identities = 112/514 (21%), Positives = 211/514 (41%), Gaps = 58/514 (11%)
Query: 1808 SGHEDNLQGEAAAGGDQDPGQSDGAEGIEAP-----------EAEGEAQPESEGV----E 1852
SG + + G ++D G SDG + + +E E +G+
Sbjct: 7 SGDQSDDGGATPVQDERDSG-SDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHH 65
Query: 1853 APEAEGD------AQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGA 1906
++E D A ++E E +D ++ E+E A+P + D E +V +
Sbjct: 66 VTDSENDEPLNLNASDSESEELHRQKDSDS-ESEERAEPPASDSENE----DVNQHGSDS 120
Query: 1907 EAPEAEKEAQPETESVEAL-----ETEGED-----EPESEGAEAQEAEEAAQEAEGQTQP 1956
E+ E K ++E+ E L ++E ED +SE E Q++ + E E +P
Sbjct: 121 ESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKP 180
Query: 1957 ESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQP---ESEDVEAPEAEGEMQEAE 2013
+ ES+E +SE+ E + + E+E +P +SE E P + E E
Sbjct: 181 QISDSESEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENE 240
Query: 2014 EEAQPESDGVEAQ--PKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE-EEAQEAEGE 2070
E +P E++ P+ + +++ E + + +A ++E EE +
Sbjct: 241 ELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVS 300
Query: 2071 VQEAEGEAHPESEDVDAQEAEGEAQ-PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPES 2129
E+EG + D + ++A Q PES+ E +GE + + + +
Sbjct: 301 DSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKF 360
Query: 2130 EGIEAPEAEGEAQPESEGVEAQDAEGE--AQPESEGIEAQEAEEEAQPELEGV--EAPEA 2185
++ E E + Q + ++ E E A+ ++ + E EE+A + V +A ++
Sbjct: 361 HSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDS 420
Query: 2186 EGEAQPESEGIE----APEAEGEAQPELEGVEAPE-----AEEEAQPEPEGVETPEAEGE 2236
+ +A + G A ++E EA EL + E ++ E+ E E + + GE
Sbjct: 421 DSDAVSDKSGKREKTIASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEENL-IADIFGE 479
Query: 2237 AQPESEGETQGEKKGSPQVSLGDGQSEEASESSS 2270
+ E E E G + + G+ Q +EA +S S
Sbjct: 480 SGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDS 513
Score = 72.8 bits (177), Expect = 4e-12
Identities = 94/445 (21%), Positives = 172/445 (38%), Gaps = 53/445 (11%)
Query: 1964 QEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGV 2023
Q+ + +DV +T E ++ E+ D E +G E +P +
Sbjct: 20 QDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNA 79
Query: 2024 EAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESE 2083
SE EE + ++E A+P + E + + ++E E E P S+
Sbjct: 80 S---DSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESE----ETRKLPGSD 132
Query: 2084 DVDAQEAEGEAQP-ESEGV-EAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEA 2141
+ + G A E+E V + P ++ E ++ + A ++E E ++ + ++E E
Sbjct: 133 SENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETE---DALKPQISDSESEE 189
Query: 2142 QPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAP-- 2199
P + A D+E E P+ + E+EE +P++ E+ E +SE E P
Sbjct: 190 PPRHQ---ASDSENEEPPKPR-MSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKP 245
Query: 2200 ---EAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESE-GETQGEKKGSPQV 2255
++E E P + A ++E E P+P ++E E P ++ +++ E+ P+V
Sbjct: 246 RISDSESEDPPRHQ---ASDSENEELPKP---RISDSESEDPPRNQASDSENEELPKPRV 299
Query: 2256 SLGDGQSEEASESSSPVPED--RPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKD 2313
S + + + +S ED R P D+ + G T +
Sbjct: 300 SDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDT----------------E 343
Query: 2314 SENDHVLGDTRSPDAK--STGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYD 2371
+ND D+ K S+ + E K +M + E EE + R +
Sbjct: 344 MQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSD---- 399
Query: 2372 LQEDQALGSLAPTEAVGRADGFGQD 2396
ED+ S + V AD D
Sbjct: 400 -SEDEEKASAKKSRVVSDADDSDSD 423
Score = 50.1 bits (118), Expect = 3e-05
Identities = 115/564 (20%), Positives = 202/564 (35%), Gaps = 77/564 (13%)
Query: 1348 GQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGL-KEEGLPEEGSVH 1406
G Q ++ +++ G E E+ G ++ + E +E+GLP+ V
Sbjct: 8 GDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVT 67
Query: 1407 GQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASE 1466
E E + + S+ ++ +++++ S EE EPP+ SE + ++
Sbjct: 68 DSENDEPLNLNASDSESEELHRQKDSDSES-----------EERAEPPASDSENE-DVNQ 115
Query: 1467 RQSGSQLEPGLEKPPGATMMGQE----HTQAQPTQGAAERSSSVACSAALDCDPIWVSVL 1522
S S+ E K PG+ +E H + + +S + L P S
Sbjct: 116 HGSDSESEE-TRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDS-- 172
Query: 1523 LKKTEKAFLAHLASAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGR 1582
+TE A ++ + +E R D +E ++ R+ DS EL K Q
Sbjct: 173 --ETEDALKPQISDSESEEPPRHQASD--------SENEEPPKPRMSDSESEELPKPQVS 222
Query: 1583 AGRMVLEPPR--------EALTGELLLQTQQR---RHRLRGLRNLSAFSERTLGLGPLSF 1631
EPPR E L + ++ RH+ N R +S
Sbjct: 223 DSESE-EPPRHQASDSENEELPKPRISDSESEDPPRHQASDSENEELPKPR------ISD 275
Query: 1632 TLEDEPALSTALGSQLGE---------EAEGEEFCPC-----EACVRKKVSPMSPKATMG 1677
+ ++P + A S+ E E+EG + P E R K P S +
Sbjct: 276 SESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDR 335
Query: 1678 ATRGPIKE----AFDLQQILQRKRGEHTDGEAAEVAPGKTHTDPTSTRTVQGAEGGLGPG 1733
+G E +F + RK+ +D E E K +D +G E +
Sbjct: 336 ENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEK---EGEEEKVAKR 392
Query: 1734 LSQ--GPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAE 1791
+ DE + R+ D D +A D + + +SE AG EL + +
Sbjct: 393 KAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASDSEEEAGKELSDKK 452
Query: 1792 QEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGV 1851
E + + G G+ E+ + GD++ + G + E +GE Q +
Sbjct: 453 NEEKDLF--GSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVK---- 506
Query: 1852 EAPEAEGDAQEAEGEAQPESEDVE 1875
EA +++ D G+ D E
Sbjct: 507 EAEDSDSDDNIKRGKHMDFLSDFE 530
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.124 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 120,082,051
Number of Sequences: 37866
Number of extensions: 7671033
Number of successful extensions: 109250
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 815
Number of HSP's successfully gapped in prelim test: 3036
Number of HSP's that attempted gapping in prelim test: 32711
Number of HSP's gapped (non-prelim): 41014
length of query: 2400
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2281
effective length of database: 13,741,464
effective search space: 31344279384
effective search space used: 31344279384
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.