Guide to the Human Genome
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Search of human proteins with 239744942

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239744942 PREDICTED: chromosome 14 open reading frame 25
[Homo sapiens]
         (1614 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom...  3232   0.0  
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...  3230   0.0  
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ...  3225   0.0  
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]       93   2e-18
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]       93   2e-18
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi...    82   4e-15
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi...    82   4e-15
gi|54607135 translocase of outer mitochondrial membrane 70 homol...    78   6e-14
gi|118766328 transmembrane and tetratricopeptide repeat containi...    71   7e-12
gi|118766330 transmembrane and tetratricopeptide repeat containi...    71   7e-12
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]                     70   2e-11
gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo ...    69   4e-11
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         66   2e-10
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform...    62   3e-09
gi|225735591 RNA polymerase II associated protein 3 isoform 1 [H...    61   8e-09
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ...    60   2e-08
gi|83415184 transmembrane and tetratricopeptide repeat containin...    60   2e-08
gi|225735593 RNA polymerase II associated protein 3 isoform 2 [H...    59   4e-08
gi|224809432 transmembrane and tetratricopeptide repeat containi...    59   5e-08
gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]           56   2e-07
gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens]          55   4e-07
gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform...    55   5e-07
gi|22749211 transmembrane and tetratricopeptide repeat containin...    55   5e-07
gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sap...    54   2e-06
gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi...    53   3e-06
gi|24308141 small glutamine-rich tetratricopeptide repeat (TPR)-...    52   5e-06
gi|225735595 RNA polymerase II associated protein 3 isoform 3 [H...    52   6e-06
gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]       48   7e-05
gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens]          47   1e-04
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ...    47   2e-04

>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
            sapiens]
          Length = 1614

 Score = 3232 bits (8381), Expect = 0.0
 Identities = 1614/1614 (100%), Positives = 1614/1614 (100%)

Query: 1    MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60
            MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA
Sbjct: 1    MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60

Query: 61   RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120
            RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF
Sbjct: 61   RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120

Query: 121  YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180
            YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
Sbjct: 121  YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180

Query: 181  LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240
            LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR
Sbjct: 181  LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240

Query: 241  EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300
            EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI
Sbjct: 241  EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300

Query: 301  RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360
            RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM
Sbjct: 301  RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360

Query: 361  SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420
            SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA
Sbjct: 361  SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420

Query: 421  KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480
            KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE
Sbjct: 421  KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480

Query: 481  LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540
            LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH
Sbjct: 481  LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540

Query: 541  IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600
            IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET
Sbjct: 541  IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600

Query: 601  LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660
            LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL
Sbjct: 601  LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660

Query: 661  RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720
            RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES
Sbjct: 661  RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720

Query: 721  IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780
            IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS
Sbjct: 721  IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780

Query: 781  KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840
            KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR
Sbjct: 781  KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840

Query: 841  TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900
            TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES
Sbjct: 841  TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900

Query: 901  EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960
            EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI
Sbjct: 901  EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960

Query: 961  YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020
            YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD
Sbjct: 961  YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020

Query: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080
            IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN
Sbjct: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080

Query: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140
            IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV
Sbjct: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140

Query: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200
            LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN
Sbjct: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200

Query: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVL 1260
            LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVL
Sbjct: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVL 1260

Query: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320
            LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF
Sbjct: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320

Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
            EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS
Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380

Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440
            FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST
Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440

Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500
            TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS
Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500

Query: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560
            KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY
Sbjct: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560

Query: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614
            ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI
Sbjct: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614


>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 3230 bits (8375), Expect = 0.0
 Identities = 1613/1614 (99%), Positives = 1613/1614 (99%)

Query: 1    MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60
            MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA
Sbjct: 1    MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60

Query: 61   RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120
            RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF
Sbjct: 61   RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120

Query: 121  YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180
            YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
Sbjct: 121  YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180

Query: 181  LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240
            LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR
Sbjct: 181  LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240

Query: 241  EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300
            EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI
Sbjct: 241  EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300

Query: 301  RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360
            RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM
Sbjct: 301  RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360

Query: 361  SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420
            SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA
Sbjct: 361  SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420

Query: 421  KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480
            KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE
Sbjct: 421  KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480

Query: 481  LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540
            LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH
Sbjct: 481  LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540

Query: 541  IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600
            IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET
Sbjct: 541  IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600

Query: 601  LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660
            LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL
Sbjct: 601  LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660

Query: 661  RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720
            RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES
Sbjct: 661  RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720

Query: 721  IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780
            IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS
Sbjct: 721  IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780

Query: 781  KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840
            KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR
Sbjct: 781  KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840

Query: 841  TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900
            TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES
Sbjct: 841  TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900

Query: 901  EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960
            EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI
Sbjct: 901  EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960

Query: 961  YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020
            YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD
Sbjct: 961  YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020

Query: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080
            IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN
Sbjct: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080

Query: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140
            IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV
Sbjct: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140

Query: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200
            LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN
Sbjct: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200

Query: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVL 1260
            LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSY AFYNRALCYTKIRELQMALTDYGIVL
Sbjct: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL 1260

Query: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320
            LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF
Sbjct: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320

Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
            EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS
Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380

Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440
            FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST
Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440

Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500
            TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS
Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500

Query: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560
            KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY
Sbjct: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560

Query: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614
            ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI
Sbjct: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614


>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
            sapiens]
          Length = 1614

 Score = 3225 bits (8362), Expect = 0.0
 Identities = 1610/1614 (99%), Positives = 1611/1614 (99%)

Query: 1    MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60
            MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA
Sbjct: 1    MSTIPRHFGLKYKEESYMFKELEKVRQETKKDFLRFKQKLASKPAVDESPVHSLHAPGPA 60

Query: 61   RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120
            RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF
Sbjct: 61   RPARVSCAAARTSRRYPSLKGPAMSAAALLQEVLGGAPRPSGLGEAAAPGKTRSFRPRDF 120

Query: 121  YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180
            YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH
Sbjct: 121  YLRSSAFLRHQALKKPPVIASGFGTARPVVLLPPPEPPVKRRARGVLESSRHAAPRRVFH 180

Query: 181  LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240
            LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR
Sbjct: 181  LGREREQSQEVAPLAGPCMAKERKASSVSAEDGYMEASSGRRKVRIRSNFVSESGAREAR 240

Query: 241  EAAGLGAQGEQESWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300
            EAAGLGAQGEQ+SWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI
Sbjct: 241  EAAGLGAQGEQDSWPPSDAREAAWQALLPSRVIPTSIEEIIASLQSEAQLASDQTIKELI 300

Query: 301  RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360
            RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM
Sbjct: 301  RSVLGQNYDITMEDISLMGKMYLKTSPMQAETPEIQAEYKFQMGAEESQMSVHKELSETM 360

Query: 361  SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420
            SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA
Sbjct: 361  SSILQIEQEDIEWGPSEAESIVFKPQEISQVQPAEELSKPLEDGQPTSDSKEAKWVSLTA 420

Query: 421  KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480
            KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE
Sbjct: 421  KSPEFLQIEGKEIKRMRKRKSLRPRKSSKPLCDKKLHKKIPQDYSMPHLHDLCTTIPAQE 480

Query: 481  LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540
            LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH
Sbjct: 481  LPVDLRLASRVYHTANRKGHDTLLGKFGTSFLDDRFTDEEQTDRILYGIPVMDDNQEYVH 540

Query: 541  IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600
            IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET
Sbjct: 541  IPPTPQGIPPELAQGTRERAHKPHLEVLGEEMYAYPEFTKLFWNTAAPKFSVPESVMKET 600

Query: 601  LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660
            LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL
Sbjct: 601  LYPKYESVQASRLLTDKLSYKSSVITLHQHSRTNFWCFLPRKSASFESIQKWFSAQPTQL 660

Query: 661  RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720
            RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES
Sbjct: 661  RRVKSSVDLRKEKIIAPLEIKNDMQSSIKEVMFQKAKELKRQLQLTKQNKTEEPNYVKES 720

Query: 721  IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780
            IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS
Sbjct: 721  IDDIFDNMCEKHSLRNLSLTLIEASKKAGISYIVYPKKKKMRWKKRLKQQKLIFVHEELS 780

Query: 781  KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840
            KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR
Sbjct: 781  KPPKSLERSASHGILPGQKKYLFKVPLYERQIRCPSLPLYLNFEKFVQAKGGIPENIDPR 840

Query: 841  TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900
            TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES
Sbjct: 841  TWALDRLIEYKDASIPVKEKDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYES 900

Query: 901  EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960
            EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI
Sbjct: 901  EVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLI 960

Query: 961  YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020
            YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD
Sbjct: 961  YLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDAD 1020

Query: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080
            IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN
Sbjct: 1021 IYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080

Query: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140
            IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV
Sbjct: 1081 IDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEV 1140

Query: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYN 1200
            LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDA SHSDKGPDAT ISADCLYN
Sbjct: 1141 LDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDASSHSDKGPDATTISADCLYN 1200

Query: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVL 1260
            LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSY AFYNRALCYTKIRELQMALTDYGIVL
Sbjct: 1201 LGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQMALTDYGIVL 1260

Query: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320
            LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF
Sbjct: 1261 LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF 1320

Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
            EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS
Sbjct: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380

Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440
            FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST
Sbjct: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440

Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500
            TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS
Sbjct: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFS 1500

Query: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560
            KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY
Sbjct: 1501 KALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQY 1560

Query: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614
            ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI
Sbjct: 1561 ELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614


>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
          Length = 1036

 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 82/302 (27%), Positives = 128/302 (42%), Gaps = 18/302 (5%)

Query: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373
            H +    + + +F T A+K NP   +AY   GN Y E G     ++A + +  AL + P 
Sbjct: 55   HFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQ---LQEAIEHYRHALRLKPD 111

Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
            +I   I+    L A G  + A   +  A+  +P  Y        V   +GN   A+  + 
Sbjct: 112  FIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY-------CVRSDLGNLLKALGRLE 164

Query: 1434 AA-----MKISTTAEFL---TNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNI 1485
             A       I T   F    +N G +    G    A+  ++ A+TL+P +  AY N GN+
Sbjct: 165  EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 224

Query: 1486 YFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAA 1545
                R F +A   + +AL   P +  V  N A         + A + +   IE  P +  
Sbjct: 225  LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 284

Query: 1546 VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQAL 1605
             Y N A+          AE+  N AL L P  A   N  A ++ + G IEEA+  Y +AL
Sbjct: 285  AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 344

Query: 1606 DL 1607
            ++
Sbjct: 345  EV 346



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 27/291 (9%)

Query: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIV 1259
            NLG  +  +G +     LAI     A+++D N   A+ N      + R    A+  Y   
Sbjct: 186  NLGCVFNAQGEIW----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 241

Query: 1260 LLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRIN 1318
            L L     V      N   +Y E G    A++ +++A  L      + C+       +  
Sbjct: 242  LSLSPNHAVVHG---NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK-G 297

Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
               EA + +  AL++ P   D+     N   E G+ E   +A + + KAL + P +  A 
Sbjct: 298  SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIE---EAVRLYRKALEVFPEFAAAH 354

Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438
             +    LQ QGK Q+A  H+  AI   P    AY         MGN    MQD+  A++ 
Sbjct: 355  SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN-------MGNTLKEMQDVQGALQC 407

Query: 1439 STTA--------EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFN 1481
             T A        +  +N   IH+  G+   A+  Y+ A+ L P +  AY N
Sbjct: 408  YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCN 458



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 67/286 (23%), Positives = 128/286 (44%), Gaps = 9/286 (3%)

Query: 1225 AISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284
            AI    N   A+ N    +    E+ +A+  +   + LD      L+ ++N G +  E  
Sbjct: 173  AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF---LDAYINLGNVLKEAR 229

Query: 1285 QYGFALEDFKQAALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
             +  A+  + +A  +S  N ++ H    C ++     + A++ +  A+++ P F DAY  
Sbjct: 230  IFDRAVAAYLRALSLS-PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 288

Query: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAID 1403
              N+  E G   +  +A+  +  AL + P +  +  +     + QG  ++A   +  A++
Sbjct: 289  LANALKEKG---SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 345

Query: 1404 TDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAM 1462
              P+   A+   A V  Q G    A+     A++IS T A+  +N G   + M   Q A+
Sbjct: 346  VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 405

Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPE 1508
            + Y  AI +NP ++ A+ N  +I+       +A   +  ALK  P+
Sbjct: 406  QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 96/394 (24%), Positives = 152/394 (38%), Gaps = 61/394 (15%)

Query: 1264 ATETVKLNTFL-----NRGLIYVELGQYGFALEDFKQAALISRT--NGSLCHATAMCHHR 1316
            +T  +K N  L     N G +Y E GQ   A+E ++ A  +     +G +  A A+    
Sbjct: 68   STLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALV--A 125

Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK 1376
              + E AV  +  AL+ NP         GN     G  E  K     +LKA+   P +  
Sbjct: 126  AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPNFAV 182

Query: 1377 ARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAM 1436
            A  + G    AQG+   A +HF  A+  DP    AY       + +GN     +  + A+
Sbjct: 183  AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY-------INLGNVLKEARIFDRAV 235

Query: 1437 KISTTAEFLT-NRGVIHEFMG---HKQN----AMKDYQDAITLNPKYSLAYFNAGNIYFH 1488
                 A  L+ N  V+H  +    ++Q     A+  Y+ AI L P +  AY N  N    
Sbjct: 236  AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 295

Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548
                ++A D ++ AL+  P +   L N A         EEA   +   +E  P +AA + 
Sbjct: 296  KGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHS 355

Query: 1549 NRA--------------HFYYCLK--------------------QYELAEEDLNKALSLK 1574
            N A              H+   ++                      + A +   +A+ + 
Sbjct: 356  NLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQIN 415

Query: 1575 PNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
            P  A  ++  A +    G I EA+A Y  AL L+
Sbjct: 416  PAFADAHSNLASIHKDSGNIPEAIASYRTALKLK 449



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 91/426 (21%), Positives = 155/426 (36%), Gaps = 49/426 (11%)

Query: 917  AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976
            A AY   G +Y++ G+LQ A+   +  + L+P F++ Y +     +    +  A+     
Sbjct: 79   AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 138

Query: 977  IHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV- 1035
              +YN +          + +    +  A   Y +AI++ P  A  +   G ++    ++ 
Sbjct: 139  ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 198

Query: 1036 LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLM 1095
            LAI  F K +  DP   DA +  G    E   +  A+  +   L++   ++   G   L 
Sbjct: 199  LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGN--LA 256

Query: 1096 MKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCA 1155
              YY                       +Q LI    + + +AIE+             C 
Sbjct: 257  CVYY-----------------------EQGLIDLAIDTYRRAIELQP-----HFPDAYCN 288

Query: 1156 LLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215
            L   ++ K     EA +    AL                AD L NL     E+GN++   
Sbjct: 289  LANALKEKGS-VAEAEDCYNTAL----------RLCPTHADSLNNLANIKREQGNIEEAV 337

Query: 1216 KLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
            +L       A+ +      A  N A    +  +LQ AL  Y   + +  T     + + N
Sbjct: 338  RL----YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA---DAYSN 390

Query: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
             G    E+     AL+ + +A  I+          A  H       EA+  +  ALK+ P
Sbjct: 391  MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 450

Query: 1336 CFLDAY 1341
             F DAY
Sbjct: 451  DFPDAY 456



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 8/152 (5%)

Query: 926  IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
            I R+ G ++ A+   ++ + + P F  A+ +   +   Q K+ EAL       + +    
Sbjct: 326  IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 385

Query: 986  EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV-LAIDDFSKC 1044
            +AY +     +  +D+  A+  YT+AI+  P  AD +     +++ +  +  AI  +   
Sbjct: 386  DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 445

Query: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFT 1076
            +   P   DA       YC   +    + D+T
Sbjct: 446  LKLKPDFPDA-------YCNLAHCLQIVCDWT 470


>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
          Length = 1046

 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 82/302 (27%), Positives = 128/302 (42%), Gaps = 18/302 (5%)

Query: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373
            H +    + + +F T A+K NP   +AY   GN Y E G     ++A + +  AL + P 
Sbjct: 65   HFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQ---LQEAIEHYRHALRLKPD 121

Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
            +I   I+    L A G  + A   +  A+  +P  Y        V   +GN   A+  + 
Sbjct: 122  FIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLY-------CVRSDLGNLLKALGRLE 174

Query: 1434 AA-----MKISTTAEFL---TNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNI 1485
             A       I T   F    +N G +    G    A+  ++ A+TL+P +  AY N GN+
Sbjct: 175  EAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNV 234

Query: 1486 YFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAA 1545
                R F +A   + +AL   P +  V  N A         + A + +   IE  P +  
Sbjct: 235  LKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPD 294

Query: 1546 VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQAL 1605
             Y N A+          AE+  N AL L P  A   N  A ++ + G IEEA+  Y +AL
Sbjct: 295  AYCNLANALKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKAL 354

Query: 1606 DL 1607
            ++
Sbjct: 355  EV 356



 Score = 77.4 bits (189), Expect = 1e-13
 Identities = 76/291 (26%), Positives = 119/291 (40%), Gaps = 27/291 (9%)

Query: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIV 1259
            NLG  +  +G +     LAI     A+++D N   A+ N      + R    A+  Y   
Sbjct: 196  NLGCVFNAQGEIW----LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRA 251

Query: 1260 LLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRIN 1318
            L L     V      N   +Y E G    A++ +++A  L      + C+       +  
Sbjct: 252  LSLSPNHAVVHG---NLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEK-G 307

Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
               EA + +  AL++ P   D+     N   E G+ E   +A + + KAL + P +  A 
Sbjct: 308  SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIE---EAVRLYRKALEVFPEFAAAH 364

Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438
             +    LQ QGK Q+A  H+  AI   P    AY         MGN    MQD+  A++ 
Sbjct: 365  SNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSN-------MGNTLKEMQDVQGALQC 417

Query: 1439 STTA--------EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFN 1481
             T A        +  +N   IH+  G+   A+  Y+ A+ L P +  AY N
Sbjct: 418  YTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCN 468



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 67/286 (23%), Positives = 128/286 (44%), Gaps = 9/286 (3%)

Query: 1225 AISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284
            AI    N   A+ N    +    E+ +A+  +   + LD      L+ ++N G +  E  
Sbjct: 183  AIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNF---LDAYINLGNVLKEAR 239

Query: 1285 QYGFALEDFKQAALISRTNGSLCHATAMC-HHRINEFEEAVNFFTWALKINPCFLDAYVG 1343
             +  A+  + +A  +S  N ++ H    C ++     + A++ +  A+++ P F DAY  
Sbjct: 240  IFDRAVAAYLRALSLS-PNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCN 298

Query: 1344 RGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAID 1403
              N+  E G   +  +A+  +  AL + P +  +  +     + QG  ++A   +  A++
Sbjct: 299  LANALKEKG---SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALE 355

Query: 1404 TDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAM 1462
              P+   A+   A V  Q G    A+     A++IS T A+  +N G   + M   Q A+
Sbjct: 356  VFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGAL 415

Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPE 1508
            + Y  AI +NP ++ A+ N  +I+       +A   +  ALK  P+
Sbjct: 416  QCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 96/394 (24%), Positives = 152/394 (38%), Gaps = 61/394 (15%)

Query: 1264 ATETVKLNTFL-----NRGLIYVELGQYGFALEDFKQAALISRT--NGSLCHATAMCHHR 1316
            +T  +K N  L     N G +Y E GQ   A+E ++ A  +     +G +  A A+    
Sbjct: 78   STLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALV--A 135

Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK 1376
              + E AV  +  AL+ NP         GN     G  E  K     +LKA+   P +  
Sbjct: 136  AGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKAC---YLKAIETQPNFAV 192

Query: 1377 ARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAM 1436
            A  + G    AQG+   A +HF  A+  DP    AY       + +GN     +  + A+
Sbjct: 193  AWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAY-------INLGNVLKEARIFDRAV 245

Query: 1437 KISTTAEFLT-NRGVIHEFMG---HKQN----AMKDYQDAITLNPKYSLAYFNAGNIYFH 1488
                 A  L+ N  V+H  +    ++Q     A+  Y+ AI L P +  AY N  N    
Sbjct: 246  AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 305

Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548
                ++A D ++ AL+  P +   L N A         EEA   +   +E  P +AA + 
Sbjct: 306  KGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHS 365

Query: 1549 NRA--------------HFYYCLK--------------------QYELAEEDLNKALSLK 1574
            N A              H+   ++                      + A +   +A+ + 
Sbjct: 366  NLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQIN 425

Query: 1575 PNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
            P  A  ++  A +    G I EA+A Y  AL L+
Sbjct: 426  PAFADAHSNLASIHKDSGNIPEAIASYRTALKLK 459



 Score = 57.4 bits (137), Expect = 1e-07
 Identities = 91/426 (21%), Positives = 155/426 (36%), Gaps = 49/426 (11%)

Query: 917  AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976
            A AY   G +Y++ G+LQ A+   +  + L+P F++ Y +     +    +  A+     
Sbjct: 89   AEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEGAVQAYVS 148

Query: 977  IHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV- 1035
              +YN +          + +    +  A   Y +AI++ P  A  +   G ++    ++ 
Sbjct: 149  ALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIW 208

Query: 1036 LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLM 1095
            LAI  F K +  DP   DA +  G    E   +  A+  +   L++   ++   G   L 
Sbjct: 209  LAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGN--LA 266

Query: 1096 MKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCA 1155
              YY                       +Q LI    + + +AIE+             C 
Sbjct: 267  CVYY-----------------------EQGLIDLAIDTYRRAIELQP-----HFPDAYCN 298

Query: 1156 LLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215
            L   ++ K     EA +    AL                AD L NL     E+GN++   
Sbjct: 299  LANALKEKGS-VAEAEDCYNTAL----------RLCPTHADSLNNLANIKREQGNIEEAV 347

Query: 1216 KLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
            +L       A+ +      A  N A    +  +LQ AL  Y   + +  T     + + N
Sbjct: 348  RL----YRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA---DAYSN 400

Query: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
             G    E+     AL+ + +A  I+          A  H       EA+  +  ALK+ P
Sbjct: 401  MGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKP 460

Query: 1336 CFLDAY 1341
             F DAY
Sbjct: 461  DFPDAY 466



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 32/152 (21%), Positives = 65/152 (42%), Gaps = 8/152 (5%)

Query: 926  IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
            I R+ G ++ A+   ++ + + P F  A+ +   +   Q K+ EAL       + +    
Sbjct: 336  IKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA 395

Query: 986  EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKV-LAIDDFSKC 1044
            +AY +     +  +D+  A+  YT+AI+  P  AD +     +++ +  +  AI  +   
Sbjct: 396  DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTA 455

Query: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFT 1076
            +   P   DA       YC   +    + D+T
Sbjct: 456  LKLKPDFPDA-------YCNLAHCLQIVCDWT 480


>gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapiens]
          Length = 830

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 8/194 (4%)

Query: 1423 GNNFAAMQDINAAMKISTTA-EFLTNRGVIHEFMGHK-------QNAMKDYQDAITLNPK 1474
            GN F+  ++ + A+K    A +   N    +  +GH+         A+  +++AI +NP+
Sbjct: 580  GNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPR 639

Query: 1475 YSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534
            +  A++  G IY+   +FS A  +F KAL  +P++  +L +  +    LKK E+A +   
Sbjct: 640  HYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLN 699

Query: 1535 NVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594
              I   P      F+RA   +  ++Y+ A ++L +   + P ++LVY    KV  K+G  
Sbjct: 700  KAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 759

Query: 1595 EEAMADYNQALDLE 1608
              A+ +++ A+DL+
Sbjct: 760  HLALMNFSWAMDLD 773



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 4/221 (1%)

Query: 1309 ATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKAL 1368
            A   C     E + A+ FF  A++++P +  AY   G+   E+   E   +A   F  A+
Sbjct: 578  AAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGH---EFVLTEELDKALACFRNAI 634

Query: 1369 HINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAA 1428
             +NP +  A    G     Q KF  A  HF  A+D +P++ +      VV   +  +  A
Sbjct: 635  RVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 694

Query: 1429 MQDINAAMKISTTAEFLTNRGVIHEFMGHK-QNAMKDYQDAITLNPKYSLAYFNAGNIYF 1487
            +  +N A+ I               F   K ++A+++ ++   + PK SL YF  G +Y 
Sbjct: 695  LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYK 754

Query: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEE 1528
               Q   A   FS A+  DP+     +  AI    L   EE
Sbjct: 755  KLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEE 795



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 1275 NRGLIYVELGQYGFALEDFKQAALIS---------RTNGSLCHATAMCHHRINEFEEAVN 1325
            N G +  ++G+  F L ++ QA  I          R  G   ++T + H + +     ++
Sbjct: 503  NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLS 562

Query: 1326 F-FTWALKINPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383
               T   K +P   +A+   GN + ++  HD A K     F +A+ ++P Y  A    G+
Sbjct: 563  KDLTDMDKNSP---EAWCAAGNCFSLQREHDIAIKF----FQRAIQVDPNYAYAYTLLGH 615

Query: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAE 1443
                  +  KA   F  AI  +P++Y A+ G                             
Sbjct: 616  EFVLTEELDKALACFRNAIRVNPRHYNAWYGL---------------------------- 647

Query: 1444 FLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKAL 1503
                 G+I+        A   +Q A+ +NP+ S+   + G +    ++  +A D  +KA+
Sbjct: 648  -----GMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 702

Query: 1504 KFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA 1563
              DP+N     +RA      +KY+ A ++   + +  P  + VYF     Y  L Q  LA
Sbjct: 703  VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLA 762

Query: 1564 EEDLNKALSLKPNDA 1578
              + + A+ L P  A
Sbjct: 763  LMNFSWAMDLDPKGA 777



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 43/199 (21%), Positives = 86/199 (43%), Gaps = 4/199 (2%)

Query: 902  VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961
            + +L++++ D  K    A+C  G  +    +   A+   QR I ++P +  AY      +
Sbjct: 558  LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 617

Query: 962  LFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADI 1021
            +  +++++AL       + N  +  A+     IY  ++  +LA +++ +A+   P  + +
Sbjct: 618  VLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 677

Query: 1022 YFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080
                G +     K   A+D  +K I  DPK       R      NE + +A+++   L  
Sbjct: 678  LCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQ 737

Query: 1081 IDHQNSQARGQYLLMMKYY 1099
            I  + S     Y L+ K Y
Sbjct: 738  IVPKESLV---YFLIGKVY 753



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 38/152 (25%), Positives = 67/152 (44%), Gaps = 10/152 (6%)

Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522
            KD  D    +P+   A+  AGN +   R+   A  +F +A++ DP   Y          +
Sbjct: 563  KDLTDMDKNSPE---AWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 619

Query: 1523 LKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582
             ++ ++A   F N I   P     ++     YY  +++ LAE    KAL + P  +++  
Sbjct: 620  TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL- 678

Query: 1583 FRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614
                    IG+++ A+    +ALD  + A VI
Sbjct: 679  ------CHIGVVQHALKKSEKALDTLNKAIVI 704



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 28/128 (21%), Positives = 55/128 (42%), Gaps = 4/128 (3%)

Query: 897  YYESEVKILTE----EINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLN 952
            YY+ E   L E    +  D     +   C  G +   L K + A++ L + I+++P    
Sbjct: 651  YYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 710

Query: 953  AYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAI 1012
              +HR  +    +K   AL +L  + +     +  Y    ++Y+      LA++N++ A+
Sbjct: 711  CKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAM 770

Query: 1013 KSTPTDAD 1020
               P  A+
Sbjct: 771  DLDPKGAN 778



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 21/194 (10%)

Query: 907  EEINDKTKYPAFAY------CRRGAIYRKLGKLQSAMNDLQRVILLE-------PLFLNA 953
            E IN  +  P+  Y      C+ G  Y +L +   A      V  +E        ++   
Sbjct: 489  EAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT 548

Query: 954  YWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIK 1013
             WH          +++ L D++      KN+ EA+ +    +  +++  +AI  + +AI+
Sbjct: 549  LWHLQKDVALS-VLSKDLTDMD------KNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQ 601

Query: 1014 STPTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAI 1072
              P  A  Y   G  + +T ++  A+  F   I  +P+  +A    G+ Y + E +  A 
Sbjct: 602  VDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAE 661

Query: 1073 EDFTALLNIDHQNS 1086
              F   L+I+ Q+S
Sbjct: 662  MHFQKALDINPQSS 675


>gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapiens]
          Length = 824

 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 52/194 (26%), Positives = 99/194 (51%), Gaps = 8/194 (4%)

Query: 1423 GNNFAAMQDINAAMKISTTA-EFLTNRGVIHEFMGHK-------QNAMKDYQDAITLNPK 1474
            GN F+  ++ + A+K    A +   N    +  +GH+         A+  +++AI +NP+
Sbjct: 574  GNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPR 633

Query: 1475 YSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534
            +  A++  G IY+   +FS A  +F KAL  +P++  +L +  +    LKK E+A +   
Sbjct: 634  HYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLN 693

Query: 1535 NVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594
              I   P      F+RA   +  ++Y+ A ++L +   + P ++LVY    KV  K+G  
Sbjct: 694  KAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQT 753

Query: 1595 EEAMADYNQALDLE 1608
              A+ +++ A+DL+
Sbjct: 754  HLALMNFSWAMDLD 767



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 58/221 (26%), Positives = 93/221 (42%), Gaps = 4/221 (1%)

Query: 1309 ATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKAL 1368
            A   C     E + A+ FF  A++++P +  AY   G+   E+   E   +A   F  A+
Sbjct: 572  AAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGH---EFVLTEELDKALACFRNAI 628

Query: 1369 HINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAA 1428
             +NP +  A    G     Q KF  A  HF  A+D +P++ +      VV   +  +  A
Sbjct: 629  RVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKA 688

Query: 1429 MQDINAAMKISTTAEFLTNRGVIHEFMGHK-QNAMKDYQDAITLNPKYSLAYFNAGNIYF 1487
            +  +N A+ I               F   K ++A+++ ++   + PK SL YF  G +Y 
Sbjct: 689  LDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYK 748

Query: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEE 1528
               Q   A   FS A+  DP+     +  AI    L   EE
Sbjct: 749  KLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEE 789



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 71/315 (22%), Positives = 126/315 (40%), Gaps = 51/315 (16%)

Query: 1275 NRGLIYVELGQYGFALEDFKQAALIS---------RTNGSLCHATAMCHHRINEFEEAVN 1325
            N G +  ++G+  F L ++ QA  I          R  G   ++T + H + +     ++
Sbjct: 497  NTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLS 556

Query: 1326 F-FTWALKINPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383
               T   K +P   +A+   GN + ++  HD A K     F +A+ ++P Y  A    G+
Sbjct: 557  KDLTDMDKNSP---EAWCAAGNCFSLQREHDIAIKF----FQRAIQVDPNYAYAYTLLGH 609

Query: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAE 1443
                  +  KA   F  AI  +P++Y A+ G                             
Sbjct: 610  EFVLTEELDKALACFRNAIRVNPRHYNAWYGL---------------------------- 641

Query: 1444 FLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKAL 1503
                 G+I+        A   +Q A+ +NP+ S+   + G +    ++  +A D  +KA+
Sbjct: 642  -----GMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAI 696

Query: 1504 KFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA 1563
              DP+N     +RA      +KY+ A ++   + +  P  + VYF     Y  L Q  LA
Sbjct: 697  VIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLA 756

Query: 1564 EEDLNKALSLKPNDA 1578
              + + A+ L P  A
Sbjct: 757  LMNFSWAMDLDPKGA 771



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 43/199 (21%), Positives = 86/199 (43%), Gaps = 4/199 (2%)

Query: 902  VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961
            + +L++++ D  K    A+C  G  +    +   A+   QR I ++P +  AY      +
Sbjct: 552  LSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEF 611

Query: 962  LFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADI 1021
            +  +++++AL       + N  +  A+     IY  ++  +LA +++ +A+   P  + +
Sbjct: 612  VLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVL 671

Query: 1022 YFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLN 1080
                G +     K   A+D  +K I  DPK       R      NE + +A+++   L  
Sbjct: 672  LCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQ 731

Query: 1081 IDHQNSQARGQYLLMMKYY 1099
            I  + S     Y L+ K Y
Sbjct: 732  IVPKESLV---YFLIGKVY 747



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 38/152 (25%), Positives = 67/152 (44%), Gaps = 10/152 (6%)

Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522
            KD  D    +P+   A+  AGN +   R+   A  +F +A++ DP   Y          +
Sbjct: 557  KDLTDMDKNSPE---AWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVL 613

Query: 1523 LKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582
             ++ ++A   F N I   P     ++     YY  +++ LAE    KAL + P  +++  
Sbjct: 614  TEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLL- 672

Query: 1583 FRAKVRGKIGLIEEAMADYNQALDLEDYASVI 1614
                    IG+++ A+    +ALD  + A VI
Sbjct: 673  ------CHIGVVQHALKKSEKALDTLNKAIVI 698



 Score = 42.0 bits (97), Expect = 0.005
 Identities = 28/128 (21%), Positives = 55/128 (42%), Gaps = 4/128 (3%)

Query: 897  YYESEVKILTE----EINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLN 952
            YY+ E   L E    +  D     +   C  G +   L K + A++ L + I+++P    
Sbjct: 645  YYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPL 704

Query: 953  AYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAI 1012
              +HR  +    +K   AL +L  + +     +  Y    ++Y+      LA++N++ A+
Sbjct: 705  CKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAM 764

Query: 1013 KSTPTDAD 1020
               P  A+
Sbjct: 765  DLDPKGAN 772



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 43/194 (22%), Positives = 81/194 (41%), Gaps = 21/194 (10%)

Query: 907  EEINDKTKYPAFAY------CRRGAIYRKLGKLQSAMNDLQRVILLE-------PLFLNA 953
            E IN  +  P+  Y      C+ G  Y +L +   A      V  +E        ++   
Sbjct: 483  EAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTT 542

Query: 954  YWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIK 1013
             WH          +++ L D++      KN+ EA+ +    +  +++  +AI  + +AI+
Sbjct: 543  LWHLQKDVALS-VLSKDLTDMD------KNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQ 595

Query: 1014 STPTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAI 1072
              P  A  Y   G  + +T ++  A+  F   I  +P+  +A    G+ Y + E +  A 
Sbjct: 596  VDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAE 655

Query: 1073 EDFTALLNIDHQNS 1086
              F   L+I+ Q+S
Sbjct: 656  MHFQKALDINPQSS 669


>gi|54607135 translocase of outer mitochondrial membrane 70 homolog A
            [Homo sapiens]
          Length = 608

 Score = 78.2 bits (191), Expect = 6e-14
 Identities = 111/493 (22%), Positives = 190/493 (38%), Gaps = 76/493 (15%)

Query: 1004 AILNYTQAIKSTPTDADI-----YFRRGEMYEITNKVLAI-DDFSKCIFYDPKRTDALLK 1057
            AI  YT+AI   PT+ ++     Y  R   +E   K   +  D +K +  +PK   AL +
Sbjct: 133  AIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFR 192

Query: 1058 RGLFYCENENWFAAIEDFTALLNID---HQNSQARGQYLLMMKYYDLAKFTIYQIAEMDK 1114
            R   + + +N    +ED TA+  ++   +Q S      +L +   + AK       E  K
Sbjct: 193  RAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAK-------EKYK 245

Query: 1115 GLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVL 1174
                L P  Q +   F    D                    ++++  +K +++ E     
Sbjct: 246  NREPLMPSPQFIKSYFSSFTDD-------------------IISQPMLKGEKSDE----- 281

Query: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMD-KNSY 1233
                      DK  +A  +  +  Y     YMEE N    Y   I++ +  I  + K   
Sbjct: 282  --------DKDKEGEALEVKENSGYLKAKQYMEEEN----YDKIISECSKEIDAEGKYMA 329

Query: 1234 TAFYNRALCYTKIRELQMALTDYG-IVLLLDATETVKLNTFLNRGLIYVELGQYGFALED 1292
             A   RA  Y  I     A  D   ++ L +A   ++ N  + RG +Y++  Q   + +D
Sbjct: 330  EALLLRATFYLLIGNANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQD 389

Query: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINP---------CFL---DA 1340
            F  AA I   N  + H        +++ EEAV  F   +++ P         CF     A
Sbjct: 390  FNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQA 449

Query: 1341 YVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTI 1400
            Y G  +S ++         A K F + +   P   +    +   L  Q +F KA   +  
Sbjct: 450  YTGNNSSQIQ--------AAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDK 501

Query: 1401 AIDTDPKNYLAYEGRAVVCLQMGNNF-AAMQDINAAMKISTTAEF-LTNRGVIHEFMGHK 1458
             ID +P N   Y  + ++ LQ   +    ++ I+ A++I    +F     G I    G+ 
Sbjct: 502  CIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNKCDFAYETMGTIEVQRGNM 561

Query: 1459 QNAMKDYQDAITL 1471
            + A+  +  AI L
Sbjct: 562  EKAIDMFNKAINL 574



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 73/327 (22%), Positives = 130/327 (39%), Gaps = 53/327 (16%)

Query: 1314 HHRINEFEEAVNFFTWALKINPCF--LDAYVGRGNSYMEYGHDEATKQAQKDFLKALHIN 1371
            + +  ++E+A+  +T A+ + P    +D      N    +   +  K+  +D  KA+ +N
Sbjct: 124  YFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELN 183

Query: 1372 PAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQD 1431
            P Y+KA             F++A  H  +    D K     +  AV  L+   N  +M  
Sbjct: 184  PKYVKAL------------FRRAKAHEKL----DNKKECLEDVTAVCILEGFQNQQSMLL 227

Query: 1432 INAAMKI---STTAEFLTNR-------------------GVIHEFM--GHKQNAMKDYQD 1467
             +  +K+       E   NR                    +I + M  G K +  KD ++
Sbjct: 228  ADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKD-KE 286

Query: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYV---LMNRAITNTILK 1524
               L  K +  Y  A   Y     + +     SK +  D E +Y+   L+ RA    ++ 
Sbjct: 287  GEALEVKENSGYLKAKQ-YMEEENYDKIISECSKEI--DAEGKYMAEALLLRATFYLLIG 343

Query: 1525 KYEEAKEDFANVIE----SCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580
                AK D   VI     +    A     R   Y   +Q  L+ +D N A  + P +A V
Sbjct: 344  NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403

Query: 1581 YNFRAKVRGKIGLIEEAMADYNQALDL 1607
            Y+ R +++  +  +EEA+AD+++ + L
Sbjct: 404  YHHRGQLKILLDQVEEAVADFDECIRL 430



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 51/225 (22%), Positives = 94/225 (41%), Gaps = 20/225 (8%)

Query: 1371 NPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG--RAVVCLQMGNNFAA 1428
            N  Y+KA+         +  + K  +  +  ID + K Y+A     RA   L +GN  AA
Sbjct: 295  NSGYLKAK-----QYMEEENYDKIISECSKEIDAEGK-YMAEALLLRATFYLLIGNANAA 348

Query: 1429 MQDINAAMKISTT-----AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAG 1483
              D++  + +        A  L  RG ++        + +D+  A  ++P+ +  Y + G
Sbjct: 349  KPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRG 408

Query: 1484 NIYFHHRQFSQASDYFSKALKFDPENE-------YVLMNRAITNTILKKYEEAKEDFANV 1536
             +     Q  +A   F + ++  PE+        + L  +A T     + + A + F  V
Sbjct: 409  QLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEV 468

Query: 1537 IESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
            I+  P  A  Y   A      +Q+  A+E  +K + L+P++A  Y
Sbjct: 469  IKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLEPDNATTY 513



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 49/244 (20%), Positives = 92/244 (37%), Gaps = 27/244 (11%)

Query: 914  KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
            K  A A  +RG++Y +  +   +  D      ++P   + Y HR  + +  D++ EA+ D
Sbjct: 364  KLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVAD 423

Query: 974  LNYIHKYNKNNTEAYLSKA-EIYR------GKKDITLAILNYTQAIKSTPTDADIYFRRG 1026
             +   +    +  A   K   +YR          I  A+  + + IK  P  A+ Y    
Sbjct: 424  FDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYA 483

Query: 1027 EMYEITNKVLAIDD-FSKCIFYDPKRTDALLKRGLFYCE-NENWFAAIEDFTALLNIDHQ 1084
            +      +    D+ + KCI  +P      + +GL   +  ++    +E  +  + ID++
Sbjct: 484  QALTDQQQFGKADEMYDKCIDLEPDNATTYVHKGLLQLQWKQDLDRGLELISKAIEIDNK 543

Query: 1085 NSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSEL--------SPMQQALIYSFCENHDK 1136
               A          Y+       Q   M+K +           S M+ A +YS C+    
Sbjct: 544  CDFA----------YETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAHA 593

Query: 1137 AIEV 1140
              EV
Sbjct: 594  QTEV 597



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 38/192 (19%), Positives = 75/192 (39%), Gaps = 15/192 (7%)

Query: 1339 DAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR----ISFGYNLQAQGKFQKA 1394
            +A + R   Y+  G+  A K    D  K + +  A +K R    I  G     Q +   +
Sbjct: 330  EALLLRATFYLLIGNANAAKP---DLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLS 386

Query: 1395 WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEF--------LT 1446
               F +A D DP+N   Y  R  + + +     A+ D +  +++   +          L 
Sbjct: 387  TQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALY 446

Query: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
             +          Q AMK +++ I   P+ +  Y          +QF +A + + K +  +
Sbjct: 447  RQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506

Query: 1507 PENEYVLMNRAI 1518
            P+N    +++ +
Sbjct: 507  PDNATTYVHKGL 518



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 83/403 (20%), Positives = 149/403 (36%), Gaps = 58/403 (14%)

Query: 1262 LDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHAT-----AMCHHR 1316
            LD     +     N+G  Y + G+Y  A++ + +A  +  T  ++  +T     A    +
Sbjct: 106  LDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQ 165

Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGH-----DEATK-------QAQKDF 1364
            + +++E     T A+++NP ++ A   R  ++ +  +     ++ T        Q Q+  
Sbjct: 166  LQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSM 225

Query: 1365 LKALHINPAYIKARISFGYN----LQAQGKFQKAW-NHFTIAIDTDPK-------NYLAY 1412
            L A  +     K +    Y     L    +F K++ + FT  I + P             
Sbjct: 226  LLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDK 285

Query: 1413 EGRAVVCLQMGNNFAAMQ----------------DINAAMKISTTAEFLTNRGVIHEFMG 1456
            EG A+   +      A Q                +I+A  K    AE L  R   +  +G
Sbjct: 286  EGEALEVKENSGYLKAKQYMEEENYDKIISECSKEIDAEGKYM--AEALLLRATFYLLIG 343

Query: 1457 HKQNAMKDYQDAITLNPKYSLAYFNA----GNIYFHHRQFSQASDYFSKALKFDPENEYV 1512
            +   A  D    I+L         NA    G++Y   +Q   ++  F+ A   DP+N  V
Sbjct: 344  NANAAKPDLDKVISLKEANVKLRANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADV 403

Query: 1513 LMNRAITNTILKKYEEAKEDFANVIESCPFWAA-------VYFNRAHFYYCLKQYELAEE 1565
              +R     +L + EEA  DF   I   P  A          + +A+      Q + A +
Sbjct: 404  YHHRGQLKILLDQVEEAVADFDECIRLRPESALAQAQKCFALYRQAYTGNNSSQIQAAMK 463

Query: 1566 DLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
               + +   P  A  Y   A+         +A   Y++ +DLE
Sbjct: 464  GFEEVIKKFPRCAEGYALYAQALTDQQQFGKADEMYDKCIDLE 506



 Score = 37.0 bits (84), Expect = 0.15
 Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 5/91 (5%)

Query: 1525 KYEEAKEDFANVIESCPFWAAV-----YFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
            KYE+A + +   I  CP    V     Y NRA  +  L++++   +D  KA+ L P    
Sbjct: 129  KYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVK 188

Query: 1580 VYNFRAKVRGKIGLIEEAMADYNQALDLEDY 1610
                RAK   K+   +E + D      LE +
Sbjct: 189  ALFRRAKAHEKLDNKKECLEDVTAVCILEGF 219



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 23/100 (23%), Positives = 44/100 (44%), Gaps = 5/100 (5%)

Query: 879 KLKLNDYVESDLPQEVIKYYESEVKILTEEIN-DKTKYPAFAYCRRGAIYRKLGKLQSAM 937
           K K N Y ++   ++ I+ Y   + +   E N D + +    Y  R A + +L K +   
Sbjct: 118 KNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTF----YQNRAAAFEQLQKWKEVA 173

Query: 938 NDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYI 977
            D  + + L P ++ A + R   +   D   E L+D+  +
Sbjct: 174 QDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAV 213


>gi|118766328 transmembrane and tetratricopeptide repeat containing 4
            isoform 2 [Homo sapiens]
          Length = 741

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 66/294 (22%), Positives = 130/294 (44%), Gaps = 4/294 (1%)

Query: 1304 GSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKD 1363
            G L   T  C  R  E+      F  AL + P     +   G +  + G+  A   A + 
Sbjct: 448  GILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTA---AIRY 504

Query: 1364 FLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
            + +A+ +NP Y+ A  + G  L+ + + Q+A    ++A+   P    A+    +V   + 
Sbjct: 505  YREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLK 564

Query: 1424 NNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482
               AA Q    A+K      +   N G ++  +    +A+  +++A  L P++SLA+ N 
Sbjct: 565  RFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 624

Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
              +  +    +QA     +AL+  P +  ++ + A      +KY+E++  F   I++ P 
Sbjct: 625  IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 684

Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEE 1596
             A+ + N A  Y+     +LA++    +L L P  +        +R K+ L+++
Sbjct: 685  AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 738



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 43/152 (28%), Positives = 73/152 (48%)

Query: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMN 1515
            G++  A++ Y++A+ LNPKY  A  N GNI     +  +A +  S A++  P+     MN
Sbjct: 496  GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 555

Query: 1516 RAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP 1575
              I    LK++E A++ +   I+    +   Y+N    Y  L ++  A      A  LKP
Sbjct: 556  LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKP 615

Query: 1576 NDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607
              +L +N    +    G + +A A   +AL+L
Sbjct: 616  EHSLAWNNMIILLDNTGNLAQAEAVGREALEL 647


>gi|118766330 transmembrane and tetratricopeptide repeat containing 4
            isoform 1 [Homo sapiens]
          Length = 760

 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 66/294 (22%), Positives = 130/294 (44%), Gaps = 4/294 (1%)

Query: 1304 GSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKD 1363
            G L   T  C  R  E+      F  AL + P     +   G +  + G+  A   A + 
Sbjct: 467  GILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTA---AIRY 523

Query: 1364 FLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
            + +A+ +NP Y+ A  + G  L+ + + Q+A    ++A+   P    A+    +V   + 
Sbjct: 524  YREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLK 583

Query: 1424 NNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482
               AA Q    A+K      +   N G ++  +    +A+  +++A  L P++SLA+ N 
Sbjct: 584  RFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM 643

Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
              +  +    +QA     +AL+  P +  ++ + A      +KY+E++  F   I++ P 
Sbjct: 644  IILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKYKESEALFLKAIKANPN 703

Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEE 1596
             A+ + N A  Y+     +LA++    +L L P  +        +R K+ L+++
Sbjct: 704  AASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGLLRRKLELMQK 757



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 43/152 (28%), Positives = 73/152 (48%)

Query: 1456 GHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMN 1515
            G++  A++ Y++A+ LNPKY  A  N GNI     +  +A +  S A++  P+     MN
Sbjct: 515  GNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMN 574

Query: 1516 RAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP 1575
              I    LK++E A++ +   I+    +   Y+N    Y  L ++  A      A  LKP
Sbjct: 575  LGIVQNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNATVLKP 634

Query: 1576 NDALVYNFRAKVRGKIGLIEEAMADYNQALDL 1607
              +L +N    +    G + +A A   +AL+L
Sbjct: 635  EHSLAWNNMIILLDNTGNLAQAEAVGREALEL 666


>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
          Length = 519

 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 74/310 (23%), Positives = 136/310 (43%), Gaps = 19/310 (6%)

Query: 1283 LGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
            LG++  A+E + +AA +++ +  + H   +C+  + +F +A +    AL +N   L  Y+
Sbjct: 114  LGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLNRHDL-TYI 172

Query: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402
              G  ++  G  +   +  K   KA+  +P   +   + G      G +QKA+ H   A+
Sbjct: 173  MLGKIHLLEGDLDKAIEVYK---KAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNAL 229

Query: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINA-AMKISTTAEFLTNRGVIHEFMGHKQN- 1460
              DP NY A      +    G+   A+      A  +  +     N G+   F G K+  
Sbjct: 230  TYDPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMC--FFGKKKYV 287

Query: 1461 -AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT 1519
             A+   + A  L P      +N G ++   +Q++ A  + S A+ F P+   + M  A+ 
Sbjct: 288  AAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVA 347

Query: 1520 NTILKKYEEAKEDFANVI--ESC-PF----WAAVYFNRAHFYYCLKQYELAEEDLNKALS 1572
             T L+  E AK  +A  +  + C P     +A + +N+      L QY+  E+   K   
Sbjct: 348  LTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEK---KVSL 404

Query: 1573 LKPNDALVYN 1582
            LK N +L ++
Sbjct: 405  LKDNSSLEFD 414



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 59/257 (22%), Positives = 107/257 (41%), Gaps = 13/257 (5%)

Query: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
            ++EA K  QKD+  + ++   YI  +           +F KA +    A++ + ++ L Y
Sbjct: 124  YNEAAKLNQKDWEISHNLGVCYIYLK-----------QFNKAQDQLHNALNLN-RHDLTY 171

Query: 1413 EGRAVVCLQMGNNFAAMQDINAAMKIST-TAEFLTNRGVIHEFMGHKQNAMKDYQDAITL 1471
                 + L  G+   A++    A++ S    E LT  G+++  +G  Q A +   +A+T 
Sbjct: 172  IMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTY 231

Query: 1472 NPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
            +P    A   AG++   H  F  A   +       PE+  +  N  +     KKY  A  
Sbjct: 232  DPTNYKAILAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAIS 291

Query: 1532 DFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKI 1591
                     PF   + +N    +  ++QY  A   L+ A++ +P    +Y   A     +
Sbjct: 292  CLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNL 351

Query: 1592 GLIEEAMADYNQALDLE 1608
              IE A   Y +A+ L+
Sbjct: 352  EDIENAKRAYAEAVHLD 368



 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 40/169 (23%), Positives = 73/169 (43%), Gaps = 7/169 (4%)

Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
            Y++A I      + +G  Q++   F       P++    +  A     +G + AA++  N
Sbjct: 71   YVQALI-----FRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYN 125

Query: 1434 AAMKISTTA-EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
             A K++    E   N GV + ++     A     +A+ LN ++ L Y   G I+      
Sbjct: 126  EAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN-RHDLTYIMLGKIHLLEGDL 184

Query: 1493 SQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCP 1541
             +A + + KA++F PEN  +L    +    L  Y++A E   N +   P
Sbjct: 185  DKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 81/376 (21%), Positives = 146/376 (38%), Gaps = 29/376 (7%)

Query: 1097 KYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCAL 1156
            K Y+  K  I +  +  +GL E +   QALI+    N  +++E+             CA+
Sbjct: 46   KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQ----------TCAV 95

Query: 1157 LAKVQM-KAKRTKEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY 1215
            L+       K+   ++ +L K   AI   ++         +  +NLG+CY+        +
Sbjct: 96   LSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYI----YLKQF 151

Query: 1216 KLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFL- 1274
              A   L  A++++++  T      +   KI  L+  L D  I +   A E    NT L 
Sbjct: 152  NKAQDQLHNALNLNRHDLTY-----IMLGKIHLLEGDL-DKAIEVYKKAVEFSPENTELL 205

Query: 1275 -NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKI 1333
               GL+Y++LG Y  A E    A     TN     A         +F+ A+  +    ++
Sbjct: 206  TTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAGSMMQTHGDFDVALTKY----RV 261

Query: 1334 NPCFLDAYVGRGNSY-MEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392
              C +       N+  M +   +    A     +A ++ P   K   + G       ++ 
Sbjct: 262  VACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYA 321

Query: 1393 KAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT-NRGVI 1451
             A++  + AI+  PK    Y   AV    + +   A +    A+ +      +  N  V+
Sbjct: 322  SAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVL 381

Query: 1452 HEFMGHKQNAMKDYQD 1467
                G K+NA+  YQ+
Sbjct: 382  LYNQGEKKNALAQYQE 397



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 83/419 (19%), Positives = 144/419 (34%), Gaps = 61/419 (14%)

Query: 896  KYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYW 955
            K YE+   ++ E++ +      +A   +  I+R  G +Q ++   Q   +L P   +   
Sbjct: 46   KDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQSADNLK 105

Query: 956  HRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKST 1015
                      K   A++  N   K N+ + E   +    Y   K    A      A+   
Sbjct: 106  QVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQDQLHNALNLN 165

Query: 1016 PTDADIYFRRGEMYEITNKV-LAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIED 1074
              D   Y   G+++ +   +  AI+ + K + + P+ T+ L   GL Y +   +  A E 
Sbjct: 166  RHDL-TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEH 224

Query: 1075 FTALLNIDHQNSQ---ARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQQALIYSFC 1131
                L  D  N +   A G  +     +D+A  T Y++      + E  P+         
Sbjct: 225  LGNALTYDPTNYKAILAAGSMMQTHGDFDVA-LTKYRVVAC--AVPESPPL--------- 272

Query: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191
                          WN   M                       KK + AIS   +     
Sbjct: 273  --------------WNNIGMCFFG------------------KKKYVAAISCLKRANYLA 300

Query: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQM 1251
                  LYNLGL ++        Y  A   L+ AI+        +   A+  T + +++ 
Sbjct: 301  PFDWKILYNLGLVHL----TMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIEN 356

Query: 1252 ALTDYGIVLLLD-ATETVKLN---TFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
            A   Y   + LD     V LN      N+G     L QY    ++ ++   + + N SL
Sbjct: 357  AKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQY----QEMEKKVSLLKDNSSL 411


>gi|170784867 tetratricopeptide repeat domain 13 isoform a [Homo
            sapiens]
          Length = 860

 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 56/241 (23%), Positives = 99/241 (41%), Gaps = 7/241 (2%)

Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG-----NNFAAMQDIN 1433
            ++  Y L   G + +A  HF+  +  +P    A  GR +   + G     N   A+ +++
Sbjct: 147  LAIAYVLIGSGLYDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELS 206

Query: 1434 AAMKISTTA-EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
              + +     E    R  I   +G    A+ D   AI L P   L Y + G +YF    +
Sbjct: 207  RVITLEPDRPEVFEQRAEILSPLGRINEAVNDLTKAIQLQPSARL-YRHRGTLYFISEDY 265

Query: 1493 SQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAH 1552
            + A + F ++L+ +      ++ + +T       +EA E F   ++    +   Y +   
Sbjct: 266  ATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQ 325

Query: 1553 FYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYAS 1612
             Y  L  +E A E   KAL L  N       R  +    G ++EA+ ++ + L LE Y  
Sbjct: 326  AYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNE 385

Query: 1613 V 1613
            V
Sbjct: 386  V 386



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 55/234 (23%), Positives = 105/234 (44%), Gaps = 8/234 (3%)

Query: 1198 LYNLGLCYMEEGNLQM-TYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDY 1256
            +Y  G+ Y ++G   +   +LA+ +L+  I+++ +    F  RA   + +  +  A+ D 
Sbjct: 180  IYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEVFEQRAEILSPLGRINEAVNDL 239

Query: 1257 GIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
               + L  +  +    + +RG +Y     Y  A EDF+Q+  +++          +    
Sbjct: 240  TKAIQLQPSARL----YRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFH 295

Query: 1317 INEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK 1376
                +EA+  F  ALK    F+DAY   G +Y E G+ EA   A + F KAL +N  +++
Sbjct: 296  RGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEA---ATESFQKALLLNQNHVQ 352

Query: 1377 ARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQ 1430
                 G  L   G  Q+A  +F   +  +P N +    + +  + MG  +  ++
Sbjct: 353  TLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIK 406



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 51/205 (24%), Positives = 90/205 (43%), Gaps = 4/205 (1%)

Query: 922  RRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYN 981
            +R  I   LG++  A+NDL + I L+P     Y HR  +Y   +    A +D     + N
Sbjct: 221  QRAEILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELN 279

Query: 982  KNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDD 1040
            KN   A L K   +  +  +  AI ++ +A+K      D Y   G+ Y E+ N   A + 
Sbjct: 280  KNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATES 339

Query: 1041 FSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYD 1100
            F K +  +      L  RG+    + +   A+++F   L ++  N     QY+  + +  
Sbjct: 340  FQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC--QYMKGLSHVA 397

Query: 1101 LAKFTIYQIAEMDKGLSELSPMQQA 1125
            + +F     A+    L++  P Q+A
Sbjct: 398  MGQFYEGIKAQTKVMLNDPLPGQKA 422



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 70/299 (23%), Positives = 116/299 (38%), Gaps = 47/299 (15%)

Query: 1215 YKLAITDLTTAISMDKNSYTAFYNRALCYTK-----IRELQMALTDYGIVLLLDATETVK 1269
            Y  AI   +T +  + +  +A Y R + Y K     I+  ++AL +   V+ L+      
Sbjct: 159  YDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRP-- 216

Query: 1270 LNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTW 1329
                                 E F+Q A I    G           RINE   AVN  T 
Sbjct: 217  ---------------------EVFEQRAEILSPLG-----------RINE---AVNDLTK 241

Query: 1330 ALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQG 1389
            A+++ P     Y  RG  Y     D AT  A +DF ++L +N     A +  G     +G
Sbjct: 242  AIQLQPS-ARLYRHRGTLYF-ISEDYAT--AHEDFQQSLELNKNQPIAMLYKGLTFFHRG 297

Query: 1390 KFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNR 1448
              ++A   F  A+        AY+       ++GN  AA +    A+ ++    + L  R
Sbjct: 298  LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLR 357

Query: 1449 GVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDP 1507
            G++    G  Q A+K+++  + L P   +  +  G  +    QF +     +K +  DP
Sbjct: 358  GMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKVMLNDP 416



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 55/245 (22%), Positives = 99/245 (40%), Gaps = 18/245 (7%)

Query: 886  VESDLPQEVIKYYESEVKILT------EEINDKTKY-----PAFAYCRRGAIYRKLGKLQ 934
            +E D P+     +E   +IL+      E +ND TK       A  Y  RG +Y       
Sbjct: 211  LEPDRPE----VFEQRAEILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYA 266

Query: 935  SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEI 994
            +A  D Q+ + L      A  ++ L +  +  + EA++      K   +  +AY S  + 
Sbjct: 267  TAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQA 326

Query: 995  YRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM-YEITNKVLAIDDFSKCIFYDPKRTD 1053
            YR   +   A  ++ +A+            RG M Y   +   A+ +F +C+  +P    
Sbjct: 327  YRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 386

Query: 1054 ALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMD 1113
                +GL +     ++  I+  T ++  D    Q      L +KY  L +++ Y  A +D
Sbjct: 387  CQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKY--LREYSRYLHAHLD 444

Query: 1114 KGLSE 1118
              L+E
Sbjct: 445  TPLTE 449



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 47/246 (19%), Positives = 95/246 (38%), Gaps = 38/246 (15%)

Query: 1320 FEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG-HD-EATKQAQKDFLKALHINPAYIKA 1377
            ++EA+  F+  L+  P  + A  GRG +Y + G HD +  + A  +  + + + P   + 
Sbjct: 159  YDEAIRHFSTMLQEEPDLVSAIYGRGIAYGKKGLHDIKNAELALFELSRVITLEPDRPEV 218

Query: 1378 RISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK 1437
                   L   G+  +A N  T AI   P   L Y  R  +     +   A +D   +++
Sbjct: 219  FEQRAEILSPLGRINEAVNDLTKAIQLQPSARL-YRHRGTLYFISEDYATAHEDFQQSLE 277

Query: 1438 ISTTAEFLT--------NRGVIHEF---------------------------MGHKQNAM 1462
            ++               +RG++ E                            +G+ + A 
Sbjct: 278  LNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAAT 337

Query: 1463 KDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTI 1522
            + +Q A+ LN  +       G + +HH    +A   F + L+ +P NE     + +++  
Sbjct: 338  ESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVA 397

Query: 1523 LKKYEE 1528
            + ++ E
Sbjct: 398  MGQFYE 403


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 149/680 (21%), Positives = 277/680 (40%), Gaps = 92/680 (13%)

Query: 1000 DITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKCIFYDPKRTDALLKR 1058
            D   AI+ Y +A+   P +  +Y  R   Y +I     A+DD  K    +PK   A  ++
Sbjct: 73   DFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQ 132

Query: 1059 GLFYCENENWFAAIEDFTALLNIDHQNSQAR-GQYLLMMK--YYDLAKFTIYQIAEMDKG 1115
            G+          A+  F + L  D ++ Q   G     MK    D  + T  Q+ +M   
Sbjct: 133  GVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLEPTYQQLQKMKLD 192

Query: 1116 LSE---LSPMQQALIYSFCENHDKAIEVLD-----GISWNRAEMTMCALLAKVQMKAKRT 1167
             S    +S + Q L+ +   +H  ++ VL+     G    +   ++ + L+        T
Sbjct: 193  KSPFVVVSVVGQELLTA--GHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNT 250

Query: 1168 KEAVEVLKKALD-AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITD----- 1221
            +++   +++ LD A +  D+  +  A       NLG  +  +GN    Y+ A+T+     
Sbjct: 251  EKSTGYMQQDLDVAKTLGDQTGECRAHG-----NLGSAFFSKGN----YREALTNHRHQL 301

Query: 1222 -LTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLL---DATETVKLNTFLNRG 1277
             L   +   + + +A  +    YT I +   AL  +   +LL      E  +     N G
Sbjct: 302  VLAMKLKDREAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMG 361

Query: 1278 LIYVELGQYGFALEDFKQAALISRTNG-------SLCHATAMCHHRINEFEEAVNFFTWA 1330
             +Y+ +G +  A++  +Q   I++  G       +  +  +  H+R N F++A+++  + 
Sbjct: 362  AVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARAYSNLGSAYHYRRN-FDKAMSYHNYV 420

Query: 1331 LKINPCFLD------AYVGRGNSYMEYGHDEATKQ---AQKDFLKALHINPAYIKARISF 1381
            L++    ++      AY G G++       E  KQ    Q    + L    A  +A  + 
Sbjct: 421  LELAQELMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL 480

Query: 1382 GYNLQAQGKFQKAWN-HFT-IAIDTDPKNYLAYEGRAVVCLQMGNNFAAM---------- 1429
            G   Q +G +  A   H T + I  +  +Y A +GRA     MGN + A+          
Sbjct: 481  GIIHQMKGDYDTALKLHKTHLCIAQELSDYAA-QGRAYG--NMGNAYNALGMYDQAVKYH 537

Query: 1430 -QDINAAMKISTTAEFLTNRG---VIHEFMGHKQNAMKDYQDAITLNPKY------SLAY 1479
             Q++  +M+++  A   +  G   V ++ +G    A++ YQ+ + +  +       + A 
Sbjct: 538  RQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARAL 597

Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENE------YVLMNRAITNTILKKYEEAKEDF 1533
             N GN +    ++ QA+ Y+ + L+  P+ +       V  N    +  L  Y+EA + +
Sbjct: 598  SNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDMEGEGKVCHNLGYAHYCLGNYQEAVKYY 657

Query: 1534 ------ANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKV 1587
                  A  +      A  Y N    +  L  +  AEE     LSL  +   + N +AK 
Sbjct: 658  EQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS---LNNSQAKF 714

Query: 1588 R--GKIGLIEEAMADYNQAL 1605
            R  G +G I     D N A+
Sbjct: 715  RALGNLGDIFICKKDINGAI 734



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 104/464 (22%), Positives = 175/464 (37%), Gaps = 86/464 (18%)

Query: 1200 NLGLCYMEEGNLQMTYKLAITDLTTAISMDK------------NSYTAF--YNRALCYTK 1245
            NLG+ +  +G+     KL  T L  A  +              N+Y A   Y++A+ Y +
Sbjct: 479  NLGIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHR 538

Query: 1246 IRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGS 1305
             +ELQ+++               + +T  N  + Y  LG +  AL+ ++    I+R    
Sbjct: 539  -QELQISMEVND--------RASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRD 589

Query: 1306 L-CHATAMC-----HHRINEFEEAVNFFTWALKINPCFLDAYVGRGN-----SYMEY--- 1351
            +   A A+      H    E+ +A  ++   L++ P   D   G G       Y  Y   
Sbjct: 590  IQSEARALSNLGNFHCSRGEYVQAAPYYEQYLRLAPDLQDME-GEGKVCHNLGYAHYCLG 648

Query: 1352 GHDEATKQAQKDFL--KALHINPAYIKARISFGYNLQAQGKFQKA--WNHFTIAIDTDPK 1407
             + EA K  ++D    K LH   +  KA  + G   +A   F KA     + +++     
Sbjct: 649  NYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQSLN 708

Query: 1408 NYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQD 1467
            N  A + RA+    +G+ F   +DIN A+K      +    G+ H+    +  A      
Sbjct: 709  NSQA-KFRALG--NLGDIFICKKDINGAIKF-----YEQQLGLAHQVKDRRLEAS----- 755

Query: 1468 AITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENE-------------YVLM 1514
                      AY   G  Y   +++ +A  Y ++ L+   E                V M
Sbjct: 756  ----------AYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAVYM 805

Query: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELA----EEDLNKA 1570
                     K YEE + D    ++     A VY N       +   E A    E+ L   
Sbjct: 806  ALGKYTMAFKCYEE-QLDLGQKLKDPSLEAQVYGNMGITKMNMNVMEEAIGYFEQQLAML 864

Query: 1571 LSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALD-LEDYASV 1613
              L  N++++   R +  G +G   EA+ DY +A+   E Y SV
Sbjct: 865  QQLSGNESVLD--RGRAYGNLGDCYEALGDYEEAIKYYEQYLSV 906



 Score = 39.7 bits (91), Expect = 0.024
 Identities = 66/313 (21%), Positives = 113/313 (36%), Gaps = 73/313 (23%)

Query: 1330 ALKINPCFL----DAYVGRGNSYMEYGHDEATK---QAQKDFLKALHINPAYIKARISFG 1382
            ALKI  C L      +    ++Y   G+ E +    Q   D  K L       +A  + G
Sbjct: 222  ALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLG 281

Query: 1383 YNLQAQGKFQKAW-NH---FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI 1438
                ++G +++A  NH     +A+    +     E  +     +G+ + A+ D   A+  
Sbjct: 282  SAFFSKGNYREALTNHRHQLVLAMKLKDR-----EAASSALSSLGHVYTAIGDYPNALAS 336

Query: 1439 S--------------TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITL------NPKYSLA 1478
                           + A  L N G ++  MG  +NA++ ++  + +        + + A
Sbjct: 337  HKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKIAKDLGNKREEARA 396

Query: 1479 YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIE 1538
            Y N G+ Y + R F +A  Y +  L+   E    LM +AI                    
Sbjct: 397  YSNLGSAYHYRRNFDKAMSYHNYVLELAQE----LMEKAIE------------------- 433

Query: 1539 SCPFWAAVYFNRAHFYYCLKQYELA----EEDLNKALSLKPNDALVYNFRAKVRGKIGLI 1594
                    Y    H   C++  E A    E+ L  A  LK   A       +    +G+I
Sbjct: 434  -----MRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAA-----EGRASSNLGII 483

Query: 1595 EEAMADYNQALDL 1607
             +   DY+ AL L
Sbjct: 484  HQMKGDYDTALKL 496



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 5/96 (5%)

Query: 1313 CHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372
            CH    +F  A+  +  AL ++P     Y  R  +YM+    +   +A  D +KA  +NP
Sbjct: 69   CHD--GDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKI---QQYDKALDDAIKARLLNP 123

Query: 1373 AYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN 1408
             + KA    G  LQ  G+   A   F   +  DPK+
Sbjct: 124  KWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKS 159



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 127/625 (20%), Positives = 216/625 (34%), Gaps = 145/625 (23%)

Query: 892  QEVIKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFL 951
            QE +KYYE ++  L ++++DK    A AYC  G  ++ L     A               
Sbjct: 651  QEAVKYYEQDL-ALAKDLHDKLS-QAKAYCNLGLAFKALLNFSKAEE------------- 695

Query: 952  NAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQ- 1010
                 ++L+ L Q   N            ++    A  +  +I+  KKDI  AI  Y Q 
Sbjct: 696  ---CQKYLLSLAQSLNN------------SQAKFRALGNLGDIFICKKDINGAIKFYEQQ 740

Query: 1011 -----AIKSTPTDADIYFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLF--YC 1063
                  +K    +A  Y   G  Y +  K      + K + Y  +  +   +       C
Sbjct: 741  LGLAHQVKDRRLEASAYAALGTAYRMIQK------YDKALGYHTQELEVYQELSDLPGEC 794

Query: 1064 ENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSELSPMQ 1123
                  AA+               A G+Y +  K Y+          ++D G     P  
Sbjct: 795  RAHGHLAAV-------------YMALGKYTMAFKCYE---------EQLDLGQKLKDPSL 832

Query: 1124 QALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISH 1183
            +A +Y                            +   +M     +EA+   ++ L A+  
Sbjct: 833  EAQVY--------------------------GNMGITKMNMNVMEEAIGYFEQQL-AMLQ 865

Query: 1184 SDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRAL-- 1241
               G ++         NLG CY   G+ +   K     L+ A S+++    A   R L  
Sbjct: 866  QLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLNRMQDQAKAYRGLGN 925

Query: 1242 CYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISR 1301
             +  +  LQ AL  +   L++      +L    N+   Y ELG     L +++QA     
Sbjct: 926  GHRAMGSLQQALVCFEKRLVV----AHELGEAFNKAQAYGELGSLHSQLGNYEQA----- 976

Query: 1302 TNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG-HDEATKQA 1360
                           I+  E  +N     +K      DA  G G  Y + G +D A +  
Sbjct: 977  ---------------ISCLERQLN-IARDMKDRALESDAACGLGGVYQQMGEYDTALQYH 1020

Query: 1361 QKDFLKALHINPAYIKARI--SFGYNLQAQGKFQKA----WNHFTIAIDTDPKNYLAYEG 1414
            Q D   A   N    + R   + G   ++ G F++A      H +IA      N LA   
Sbjct: 1021 QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQ---MNDLA--A 1075

Query: 1415 RAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPK 1474
            + V    +G    A+Q+ + A+       +L     + E +G +++  K       +   
Sbjct: 1076 KTVSYSSLGRTHHALQNYSQAVM------YLQEGLRLAEQLGRREDEAK-------IRHG 1122

Query: 1475 YSLAYFNAGNIYFHHRQFSQASDYF 1499
              L+ + +GN+     Q  +AS  F
Sbjct: 1123 LGLSLWASGNLEEAQHQLYRASALF 1147



 Score = 33.5 bits (75), Expect = 1.7
 Identities = 17/63 (26%), Positives = 30/63 (47%)

Query: 1488 HHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVY 1547
            H   F  A   +++AL  DP+N  +  NR+     +++Y++A +D        P W   Y
Sbjct: 70   HDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAY 129

Query: 1548 FNR 1550
            F +
Sbjct: 130  FRQ 132


>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
            [Homo sapiens]
          Length = 494

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 87/386 (22%), Positives = 156/386 (40%), Gaps = 44/386 (11%)

Query: 1261 LLDATETVK-LNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINE 1319
            LLD  E  +   TF  +G  Y     Y  A   + +A  +   N S     A     +  
Sbjct: 18   LLDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGR 77

Query: 1320 FEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARI 1379
            F EA+     +++++  F+  ++  G  ++  G+  A   A + F +AL ++    +A+ 
Sbjct: 78   FREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMA---ACRSFQRALELDHKNAQAQQ 134

Query: 1380 SFG-------YNLQAQGKFQKAWNHFTI-----AIDTDPKNYLAYEGRAVVCLQMGNNFA 1427
             F        Y   A+  F+K      +     A++  P  +  ++     CL M   + 
Sbjct: 135  EFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACH-RFKILKAECLAMLGRYP 193

Query: 1428 AMQDINAAM--KISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP---KYSLAYFNA 1482
              Q + + +    ST A+ L  RG+   +    + A++ +  A+ + P   K  +A  NA
Sbjct: 194  EAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNA 253

Query: 1483 ---------GNIYFHHRQFSQASDYFSKALKFDPEN----EYVLMNRAITNTILKKYEEA 1529
                     GN  F    +  A + +++AL  DP N      +  NR   N+ L+K ++A
Sbjct: 254  KALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDA 313

Query: 1530 KEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKAL---SLKPNDALVYNFRAK 1586
             ED  N ++    +   Y  RA  Y   +QYE A  D  K       K +  L+ N + +
Sbjct: 314  IEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLKNAQLE 373

Query: 1587 VRGKIGLIEEAMADYNQALDLEDYAS 1612
            +R      +    DY + L ++  AS
Sbjct: 374  LR------KSKRKDYYKILGVDKNAS 393



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 81/356 (22%), Positives = 131/356 (36%), Gaps = 63/356 (17%)

Query: 969  EALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM 1028
            E LDD     +  K   E +  +   Y  KKD   A   YT+AI   P +A  Y  R   
Sbjct: 17   ELLDD-----QEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAAT 71

Query: 1029 YEITNKVL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQ 1087
              +  +   A+ D  + +  D       L+ G  +    N  AA   F   L +DH+N+Q
Sbjct: 72   LMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQ 131

Query: 1088 ARGQYL---LMMKYYDLAKFTIYQ------IAEMDKGLSELSPMQQ----------ALIY 1128
            A+ ++     +M+Y  +A+    +      +  MD+ L E +P             A++ 
Sbjct: 132  AQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRAL-EFAPACHRFKILKAECLAMLG 190

Query: 1129 SFCENHDKAIEVLDGISWNRAEMTMCAL-LAKVQMKAKRTKEAVEVLKKALDAISHSDKG 1187
             + E    A ++L   S N   + +  L L       K  +  V+ L+ A D        
Sbjct: 191  RYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIAC 250

Query: 1188 PDATAISADCLYNLGLCYMEEGNLQMTYKL------------------------------ 1217
             +A A+ A      G    +EGN ++ Y+L                              
Sbjct: 251  RNAKALKAK--KEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLR 308

Query: 1218 ----AITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVK 1269
                AI D T A+ +D     A+  RA CY    + + A+ DY  V   + T+  K
Sbjct: 309  KLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHK 364



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 26/97 (26%), Positives = 44/97 (45%), Gaps = 3/97 (3%)

Query: 898 YESEVKILTEEIN---DKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954
           Y+   ++ TE +    +  K  A  YC RG +  KL KL  A+ D    + L+  ++ AY
Sbjct: 272 YKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAY 331

Query: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK 991
             R   Y+  ++  EA+ D   +++  K      L K
Sbjct: 332 LRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLK 368


>gi|225735591 RNA polymerase II associated protein 3 isoform 1 [Homo
            sapiens]
          Length = 665

 Score = 61.2 bits (147), Expect = 8e-09
 Identities = 62/268 (23%), Positives = 110/268 (41%), Gaps = 14/268 (5%)

Query: 1355 EATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG 1414
            E+  Q  +     +H++          G     QGK+ +A + +T  +D DP N +    
Sbjct: 113  ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTN 172

Query: 1415 RAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473
            RA    ++     A  D N A+ ++ +  +  + RG     +   + A KDY+  + L P
Sbjct: 173  RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232

Query: 1474 ----------KYSLAYFNAGNIYFHHRQFS-QASDYFSKALKFDPENEYVLMNRAITNTI 1522
                      K S A  +  N Y        ++++   K ++     +  +  +   N  
Sbjct: 233  NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292

Query: 1523 LK--KYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALV 1580
             K  KYE A E +   I +    A +  NRA  Y  +++YE AE+D  +A+ L  + +  
Sbjct: 293  FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352

Query: 1581 YNFRAKVRGKIGLIEEAMADYNQALDLE 1608
            +  R   R  +G + EA  D+   L LE
Sbjct: 353  FARRGTARTFLGKLNEAKQDFETVLLLE 380



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 35/120 (29%), Positives = 59/120 (49%)

Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548
            H   SQ S+     +  D +   VL  +        KY+EA + +   +++ P+   +  
Sbjct: 112  HESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT 171

Query: 1549 NRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
            NRA  Y+ LK++ +AE D N A++L  +    Y+ R   R  +  +EEA  DY + L+LE
Sbjct: 172  NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 231



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 66/292 (22%), Positives = 116/292 (39%), Gaps = 61/292 (20%)

Query: 1022 YFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNI 1081
            YF++G+  E      AID ++K +  DP        R   Y   + +  A  D    + +
Sbjct: 143  YFKQGKYDE------AIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVAL 196

Query: 1082 DHQNSQA---RGQYLLMMKYYDLAKFTIYQIAEMD----KGLSELSPMQQALIY---SFC 1131
            +   ++A   RG     ++  + AK    ++ E++    +  +EL  + QAL     S+ 
Sbjct: 197  NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYP 256

Query: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191
            +  D  I+  +G               + Q++A++ K+          AIS  D+G    
Sbjct: 257  KEADIVIKSTEG--------------ERKQIEAQQNKQ---------QAISEKDRGNG-- 291

Query: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQM 1251
                         + +EG     Y+ AI   T  I+ D  +     NRA+ Y KI++ + 
Sbjct: 292  -------------FFKEGK----YERAIECYTRGIAADGANALLPANRAMAYLKIQKYEE 334

Query: 1252 ALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN 1303
            A  D    +LLD + +     F  RG     LG+   A +DF+   L+   N
Sbjct: 335  AEKDCTQAILLDGSYS---KAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 35/220 (15%)

Query: 919  AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978
            AY RRGA    L KL+ A  D +RV+ LEP   N +              EA ++L  I 
Sbjct: 203  AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 245

Query: 979  KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034
            +   +   +Y  +A+I      G++    A  N  QAI S     + +F+ G+ YE    
Sbjct: 246  QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 299

Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA---RGQ 1091
              AI+ +++ I  D         R + Y + + +  A +D T  + +D   S+A   RG 
Sbjct: 300  -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 358

Query: 1092 YLLMMKYYDLAKFTIYQIAEMDKG----LSELSPMQQALI 1127
                +   + AK     +  ++ G    ++ELS +++ LI
Sbjct: 359  ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELI 398



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)

Query: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334
            +RG  + + G+Y  A+E + +       N  L    AM + +I ++EEA    T A+ ++
Sbjct: 287  DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 346

Query: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372
              +  A+  RG +    G      +A++DF   L + P
Sbjct: 347  GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 381



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948
           I+ YE   K  T+ I     Y   A+ RRG     LGKL  A  D + V+LLEP
Sbjct: 329 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 381


>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
            sapiens]
          Length = 807

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 56/227 (24%), Positives = 91/227 (40%), Gaps = 16/227 (7%)

Query: 1387 AQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLT 1446
            +Q K       F  A D D  N    E  A+  + +G+         A    ST  + L+
Sbjct: 123  SQAKSIAEQKRFPFATDNDSTN----EELAIAYVLIGSGLYD----EAIRHFSTMLQILS 174

Query: 1447 NRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
              G I+E       A+ D   AI L P   L Y + G +YF    ++ A + F ++L+ +
Sbjct: 175  PLGRINE-------AVNDLTKAIQLQPSARL-YRHRGTLYFISEDYATAHEDFQQSLELN 226

Query: 1507 PENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEED 1566
                  ++ + +T       +EA E F   ++    +   Y +    Y  L  +E A E 
Sbjct: 227  KNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATES 286

Query: 1567 LNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYASV 1613
              KAL L  N       R  +    G ++EA+ ++ + L LE Y  V
Sbjct: 287  FQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 50/201 (24%), Positives = 88/201 (43%), Gaps = 4/201 (1%)

Query: 926  IYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNT 985
            I   LG++  A+NDL + I L+P     Y HR  +Y   +    A +D     + NKN  
Sbjct: 172  ILSPLGRINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQP 230

Query: 986  EAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITNKVLAIDDFSKC 1044
             A L K   +  +  +  AI ++ +A+K      D Y   G+ Y E+ N   A + F K 
Sbjct: 231  IAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKA 290

Query: 1045 IFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKF 1104
            +  +      L  RG+    + +   A+++F   L ++  N     QY+  + +  + +F
Sbjct: 291  LLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVC--QYMKGLSHVAMGQF 348

Query: 1105 TIYQIAEMDKGLSELSPMQQA 1125
                 A+    L++  P Q+A
Sbjct: 349  YEGIKAQTKVMLNDPLPGQKA 369



 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 7/172 (4%)

Query: 1263 DATETVKLNT----FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRIN 1318
            D T+ ++L      + +RG +Y     Y  A EDF+Q+  +++          +      
Sbjct: 185  DLTKAIQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRG 244

Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
              +EA+  F  ALK    F+DAY   G +Y E G+ EA   A + F KAL +N  +++  
Sbjct: 245  LLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEA---ATESFQKALLLNQNHVQTL 301

Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQ 1430
               G  L   G  Q+A  +F   +  +P N +    + +  + MG  +  ++
Sbjct: 302  QLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIK 353



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 55/245 (22%), Positives = 102/245 (41%), Gaps = 14/245 (5%)

Query: 886  VESDLPQEVIKYYESEVKILT------EEINDKTKY-----PAFAYCRRGAIYRKLGKLQ 934
            + S L  E I+++ + ++IL+      E +ND TK       A  Y  RG +Y       
Sbjct: 154  IGSGLYDEAIRHFSTMLQILSPLGRINEAVNDLTKAIQLQPSARLYRHRGTLYFISEDYA 213

Query: 935  SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEI 994
            +A  D Q+ + L      A  ++ L +  +  + EA++      K   +  +AY S  + 
Sbjct: 214  TAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQA 273

Query: 995  YRGKKDITLAILNYTQAIKSTPTDADIYFRRGEM-YEITNKVLAIDDFSKCIFYDPKRTD 1053
            YR   +   A  ++ +A+            RG M Y   +   A+ +F +C+  +P    
Sbjct: 274  YRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEV 333

Query: 1054 ALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMD 1113
                +GL +     ++  I+  T ++  D    Q      L +KY  L +++ Y  A +D
Sbjct: 334  CQYMKGLSHVAMGQFYEGIKAQTKVMLNDPLPGQKASPEYLKVKY--LREYSRYLHAHLD 391

Query: 1114 KGLSE 1118
              L+E
Sbjct: 392  TPLTE 396



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 60/245 (24%), Positives = 97/245 (39%), Gaps = 19/245 (7%)

Query: 1264 ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEA 1323
            AT+    N  L    + +  G Y  A+  F     I    G           RINE   A
Sbjct: 137  ATDNDSTNEELAIAYVLIGSGLYDEAIRHFSTMLQILSPLG-----------RINE---A 182

Query: 1324 VNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGY 1383
            VN  T A+++ P     Y  RG  Y     D AT  A +DF ++L +N     A +  G 
Sbjct: 183  VNDLTKAIQLQPS-ARLYRHRGTLYF-ISEDYAT--AHEDFQQSLELNKNQPIAMLYKGL 238

Query: 1384 NLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-A 1442
                +G  ++A   F  A+        AY+       ++GN  AA +    A+ ++    
Sbjct: 239  TFFHRGLLKEAIESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHV 298

Query: 1443 EFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKA 1502
            + L  RG++    G  Q A+K+++  + L P   +  +  G  +    QF +     +K 
Sbjct: 299  QTLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358

Query: 1503 LKFDP 1507
            +  DP
Sbjct: 359  MLNDP 363


>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
            [Homo sapiens]
          Length = 774

 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 67/305 (21%), Positives = 119/305 (39%), Gaps = 41/305 (13%)

Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
            EEA+     ++K  P F DAY    +   E    E  K+A++ +   +   P       +
Sbjct: 457  EEAITLLKDSIKYGPEFADAYSSLASLLAE---QERFKEAEEIYQTGIKNCPDSSDLHNN 513

Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIST 1440
            +G  L   G  +KA  H+  AI   P +++A      +   +G N  A +    A++++ 
Sbjct: 514  YGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAH 573

Query: 1441 TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP-----KYSLA----------------- 1478
             AE L+  G ++   G  + A++ YQ+A  L P     + +LA                 
Sbjct: 574  KAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTN 633

Query: 1479 ------------YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAIT--NTILK 1524
                        Y     IY       +A D   KAL+  P++  V+     T  N + +
Sbjct: 634  HIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLRE 693

Query: 1525 K--YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYN 1582
            +   ++A E +   ++  P  A  + N     +   +Y  A     +AL L P+  L+  
Sbjct: 694  QNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKE 753

Query: 1583 FRAKV 1587
              AK+
Sbjct: 754  NLAKL 758



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 66/325 (20%), Positives = 130/325 (40%), Gaps = 44/325 (13%)

Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
            +EA+  +  ALK+ P    A    G    +      T +A+  + +AL ++P + +A  +
Sbjct: 392  KEAIYHYRTALKLYPRHASALNNLGTLTRD------TAEAKMYYQRALQLHPQHNRALFN 445

Query: 1381 FGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-IS 1439
             G  L++Q K ++A      +I   P+   AY   A +  +      A +     +K   
Sbjct: 446  LGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCP 505

Query: 1440 TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYF 1499
             +++   N GV     G  + A+  YQ AI L+P + +A  N G +Y    + S A +++
Sbjct: 506  DSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWY 565

Query: 1500 SKALK---------------------------------FDPENEYVLMNRAITNTILKKY 1526
             +AL+                                   P    + +  A    ++ + 
Sbjct: 566  KRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQT 625

Query: 1527 EEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAK 1586
            +EA++   +++         Y   +  Y   + ++ A + ++KAL LKP D  V +    
Sbjct: 626  KEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFF 685

Query: 1587 VRG----KIGLIEEAMADYNQALDL 1607
             +G    +  L+++A   Y  A+ L
Sbjct: 686  TKGNQLREQNLLDKAFESYRVAVQL 710



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 51/220 (23%), Positives = 93/220 (42%), Gaps = 8/220 (3%)

Query: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMG 1456
            F   + T P N   +   A      G N  A+     A+K+    A  L N G +     
Sbjct: 364  FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR--- 420

Query: 1457 HKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNR 1516
                A   YQ A+ L+P+++ A FN GN+     +  +A      ++K+ PE      + 
Sbjct: 421  DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 480

Query: 1517 AITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPN 1576
            A      ++++EA+E +   I++CP  + ++ N   F       E A     +A+ L P+
Sbjct: 481  ASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPS 540

Query: 1577 DALVYNFRAKVRGKIGLIEEAMAD--YNQALDLEDYASVI 1614
              +      ++   +G  E +MA+  Y +AL +   A ++
Sbjct: 541  HHVAMVNLGRLYRSLG--ENSMAEEWYKRALQVAHKAEIL 578



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 55/283 (19%), Positives = 109/283 (38%), Gaps = 42/283 (14%)

Query: 1291 EDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFTWALKINPCFLDAYVG 1343
            E FK+A  I +T    C  ++  H+    F       E+AV  +  A+K++P    A V 
Sbjct: 488  ERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVN 547

Query: 1344 RGNSYMEYGHDEATKQAQKDFLKALH------------------------------INPA 1373
             G  Y   G +   ++  K  L+  H                              + P+
Sbjct: 548  LGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGALYYNTGRYEEALQIYQEAAALQPS 607

Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
              + R++    L   G+ ++A       +  +      Y   + +  +  N+  A+  I+
Sbjct: 608  QRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAID 667

Query: 1434 AAMKIS-----TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFH 1488
             A+++        +E    +G           A + Y+ A+ LNP  + A+ N G I   
Sbjct: 668  KALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHI 727

Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKE 1531
              ++  A  Y+ +AL+  P+++ +  N A  + + K+ +E +E
Sbjct: 728  KGKYVSARAYYERALQLVPDSKLLKENLAKLDRLEKRLQEVRE 770



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 61/264 (23%), Positives = 92/264 (34%), Gaps = 42/264 (15%)

Query: 920  YCRRGAIYRKLGKLQ----SAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLN 975
            Y R  +    LG L      A    QR + L P    A ++   +   Q+K  EA+  L 
Sbjct: 405  YPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 464

Query: 976  YIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITN-K 1034
               KY     +AY S A +   ++    A   Y   IK+ P  +D++   G     T   
Sbjct: 465  DSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDLHNNYGVFLVDTGLP 524

Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFY---CEN---ENWF------------------- 1069
              A+  + + I   P    A++  G  Y    EN   E W+                   
Sbjct: 525  EKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQVAHKAEILSPLGAL 584

Query: 1070 -----------AAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQIAEMDKGLSE 1118
                          ++  AL     +   A  Q L +M     A+     I   + G  E
Sbjct: 585  YYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLE 644

Query: 1119 LSPMQQALIYSFCENHDKAIEVLD 1142
               +  A IYS  ENHDKA++ +D
Sbjct: 645  CYRLLSA-IYSKQENHDKALDAID 667


>gi|225735593 RNA polymerase II associated protein 3 isoform 2 [Homo
            sapiens]
          Length = 631

 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 35/120 (29%), Positives = 59/120 (49%)

Query: 1489 HRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYF 1548
            H   SQ S+     +  D +   VL  +        KY+EA + +   +++ P+   +  
Sbjct: 112  HESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPT 171

Query: 1549 NRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
            NRA  Y+ LK++ +AE D N A++L  +    Y+ R   R  +  +EEA  DY + L+LE
Sbjct: 172  NRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELE 231



 Score = 54.7 bits (130), Expect = 7e-07
 Identities = 33/122 (27%), Positives = 58/122 (47%)

Query: 1466 QDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525
            +D I ++ + +L     GN YF   ++ +A D ++K +  DP N  +  NRA     LKK
Sbjct: 123  EDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKK 182

Query: 1526 YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRA 1585
            +  A+ D    +     +   Y  R    + L++ E A++D  + L L+PN+    N   
Sbjct: 183  FAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELR 242

Query: 1586 KV 1587
            K+
Sbjct: 243  KI 244



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 57/305 (18%), Positives = 115/305 (37%), Gaps = 50/305 (16%)

Query: 1355 EATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEG 1414
            E+  Q  +     +H++          G     QGK+ +A + +T  +D DP N +    
Sbjct: 113  ESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTN 172

Query: 1415 RAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473
            RA    ++     A  D N A+ ++ +  +  + RG     +   + A KDY+  + L P
Sbjct: 173  RASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP 232

Query: 1474 -----------------------------------------------KYSLAYFNAGNIY 1486
                                                           + +++  + GN +
Sbjct: 233  NNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGF 292

Query: 1487 FHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAV 1546
            F   ++ +A + +++ +  D  N  +  NRA+    ++KYEEA++D    I     ++  
Sbjct: 293  FKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352

Query: 1547 YFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGK--IGLIEEAMADYNQA 1604
            +  R      L +   A++D    L L+P +       +K++ K    +I E   +  Q 
Sbjct: 353  FARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKKPLKKVIIEETGNLIQT 412

Query: 1605 LDLED 1609
            +D+ D
Sbjct: 413  IDVPD 417



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 66/292 (22%), Positives = 116/292 (39%), Gaps = 61/292 (20%)

Query: 1022 YFRRGEMYEITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNI 1081
            YF++G+  E      AID ++K +  DP        R   Y   + +  A  D    + +
Sbjct: 143  YFKQGKYDE------AIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVAL 196

Query: 1082 DHQNSQA---RGQYLLMMKYYDLAKFTIYQIAEMD----KGLSELSPMQQALIY---SFC 1131
            +   ++A   RG     ++  + AK    ++ E++    +  +EL  + QAL     S+ 
Sbjct: 197  NRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYP 256

Query: 1132 ENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDAT 1191
            +  D  I+  +G               + Q++A++ K+          AIS  D+G    
Sbjct: 257  KEADIVIKSTEG--------------ERKQIEAQQNKQ---------QAISEKDRGNG-- 291

Query: 1192 AISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQM 1251
                         + +EG     Y+ AI   T  I+ D  +     NRA+ Y KI++ + 
Sbjct: 292  -------------FFKEGK----YERAIECYTRGIAADGANALLPANRAMAYLKIQKYEE 334

Query: 1252 ALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN 1303
            A  D    +LLD + +     F  RG     LG+   A +DF+   L+   N
Sbjct: 335  AEKDCTQAILLDGSYS---KAFARRGTARTFLGKLNEAKQDFETVLLLEPGN 383



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 47/174 (27%), Positives = 76/174 (43%), Gaps = 28/174 (16%)

Query: 919  AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978
            AY RRGA    L KL+ A  D +RV+ LEP   N +              EA ++L  I 
Sbjct: 203  AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 245

Query: 979  KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034
            +   +   +Y  +A+I      G++    A  N  QAI S     + +F+ G+ YE    
Sbjct: 246  QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 299

Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA 1088
              AI+ +++ I  D         R + Y + + +  A +D T  + +D   S+A
Sbjct: 300  -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKA 352



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)

Query: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334
            +RG  + + G+Y  A+E + +       N  L    AM + +I ++EEA    T A+ ++
Sbjct: 287  DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 346

Query: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372
              +  A+  RG +    G      +A++DF   L + P
Sbjct: 347  GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 381



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 24/87 (27%), Positives = 37/87 (42%), Gaps = 2/87 (2%)

Query: 923  RGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNK 982
            R   Y K+ K + A  D  + ILL+  +  A+  R     F  K+NEA  D   +     
Sbjct: 322  RAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEP 381

Query: 983  NNTEAYLSKAEIYRGKKDITLAILNYT 1009
             N +A    ++I   KK +   I+  T
Sbjct: 382  GNKQAVTELSKI--KKKPLKKVIIEET 406



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948
           I+ YE   K  T+ I     Y   A+ RRG     LGKL  A  D + V+LLEP
Sbjct: 329 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 381


>gi|224809432 transmembrane and tetratricopeptide repeat containing 3
            [Homo sapiens]
          Length = 914

 Score = 58.5 bits (140), Expect = 5e-08
 Identities = 76/387 (19%), Positives = 137/387 (35%), Gaps = 91/387 (23%)

Query: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
            F  A  +++ N  L +           FE A+ +F  A  + P  + A++  G +Y    
Sbjct: 435  FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494

Query: 1353 HDEATKQAQKDFLKA--------------LHINPAYIKARISFGYNLQA-QGKFQKAWNH 1397
                TK+A++ ++ A                I P ++   I+    ++A + + ++A   
Sbjct: 495  R---TKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESRLEEADQL 551

Query: 1398 FTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMG 1456
            +  AI   P    AY  R  + L+M     A +    A+++    A+   N  ++H  + 
Sbjct: 552  YRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELK 611

Query: 1457 HKQNAMKDYQDAITLNPKYSLA-------------------------------------Y 1479
                A+K++  A+ LNPK+ LA                                     Y
Sbjct: 612  EPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671

Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA--------------ITNTILKK 1525
            FN G +    ++ ++A  +  KA+K   +    L N A              I   +L+ 
Sbjct: 672  FNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPILEELLRY 731

Query: 1526 YEE---------------------AKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAE 1564
            Y +                     AK+ F  ++E  P       N    Y+  K    AE
Sbjct: 732  YPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAE 791

Query: 1565 EDLNKALSLKPNDALVYNFRAKVRGKI 1591
              L + L+L P++  +      VR KI
Sbjct: 792  RCLLETLALAPHEEYIQRHLNIVRDKI 818



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 67/292 (22%), Positives = 121/292 (41%), Gaps = 25/292 (8%)

Query: 1293 FKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYG 1352
            FK+ + I  +   L H+     HR  ++E     F  ALK+N      +   G++     
Sbjct: 402  FKKLSWICLSMVILTHSLKT-FHRNWDWESEYTLFMSALKVNKNNAKLWNNVGHALE--- 457

Query: 1353 HDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAY 1412
            +++  ++A K FL+A H+ P  I A ++ G   +   + ++A   + +A    P+     
Sbjct: 458  NEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMMAKSLMPQ----- 512

Query: 1413 EGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472
                   +  G  +AA    N          ++    +I       + A + Y+ AI++ 
Sbjct: 513  -------IIPGKKYAARIAPNHLNV------YINLANLIRANESRLEEADQLYRQAISMR 559

Query: 1473 PKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKED 1532
            P +  AY + G +     +  +A + + KAL+ D  N  +  N AI +  LK+  EA ++
Sbjct: 560  PDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKN 619

Query: 1533 FANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL---KPNDALVY 1581
            F   +E  P      FN A       + +L  E   + LS    +P DA  Y
Sbjct: 620  FNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGY 671



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 51/246 (20%), Positives = 98/246 (39%), Gaps = 10/246 (4%)

Query: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332
            +++RG + +++ +   A E + +A  + R N  L +  A+ H  + E  EA+  F  AL+
Sbjct: 566  YISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALE 625

Query: 1333 INPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQ 1392
            +NP    A         E G  +   +A+K  L  ++  P       + G       K  
Sbjct: 626  LNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEPLDANGYFNLGMLAMDDKKDN 685

Query: 1393 KA--WNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK-ISTTAEFLTNRG 1449
            +A  W    I +  D ++  A    A++  Q      A+  +   ++      + L  +G
Sbjct: 686  EAEIWMKKAIKLQADFRS--ALFNLALLYSQTAKELKALPILEELLRYYPDHIKGLILKG 743

Query: 1450 VIHEFMGHKQN---AMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFD 1506
             I   M  K++   A K ++  + ++P       N   +YF  +   +A     + L   
Sbjct: 744  DI--LMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVYFEEKDLLKAERCLLETLALA 801

Query: 1507 PENEYV 1512
            P  EY+
Sbjct: 802  PHEEYI 807



 Score = 39.3 bits (90), Expect = 0.031
 Identities = 45/192 (23%), Positives = 81/192 (42%), Gaps = 20/192 (10%)

Query: 1434 AAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQF 1492
            +A+K++   A+   N G   E   + + A+K +  A  + P    A+ N G  Y +  + 
Sbjct: 437  SALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLNRT 496

Query: 1493 SQASDYFSKALKFDPE----------------NEYV-LMNRAITNTILKKYEEAKEDFAN 1535
             +A + +  A    P+                N Y+ L N    N    + EEA + +  
Sbjct: 497  KEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANE--SRLEEADQLYRQ 554

Query: 1536 VIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIE 1595
             I   P +   Y +R      + +   A+E   KAL L  N+A ++   A V  ++    
Sbjct: 555  AISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPN 614

Query: 1596 EAMADYNQALDL 1607
            EA+ ++N+AL+L
Sbjct: 615  EALKNFNRALEL 626



 Score = 32.3 bits (72), Expect = 3.8
 Identities = 28/124 (22%), Positives = 52/124 (41%), Gaps = 2/124 (1%)

Query: 976  YIHKYNKNNTEAYLSKAEIYRGKKD-ITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034
            Y  +   N+   Y++ A + R  +  +  A   Y QAI   P     Y  RGE+    NK
Sbjct: 519  YAARIAPNHLNVYINLANLIRANESRLEEADQLYRQAISMRPDFKQAYISRGELLLKMNK 578

Query: 1035 VL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093
             L A + + K +  D    D      + + E +    A+++F   L ++ ++  A     
Sbjct: 579  PLKAKEAYLKALELDRNNADLWYNLAIVHIELKEPNEALKNFNRALELNPKHKLALFNSA 638

Query: 1094 LMMK 1097
            ++M+
Sbjct: 639  IVMQ 642


>gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens]
          Length = 1564

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 89/388 (22%), Positives = 155/388 (39%), Gaps = 37/388 (9%)

Query: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTY-KLAITDLTTAISMDKN-- 1231
            KK  DA+ +  +G   + +     Y+L      E  ++M   K A+   + A+ +  N  
Sbjct: 286  KKYEDAVRNLTEGLKESPVCTSGWYHLA-----EAQVKMHRPKEAVLSCSQALKIVDNLG 340

Query: 1232 -SYTAFYNRALCYTKIRELQMALTDYG--------IVLLLDATETVKLNTFLNRGLIYVE 1282
             S  + Y R LC     E  + L+DY         +  + DA     L   + + L Y  
Sbjct: 341  ASGNSLYQRNLCLHLKAEALIKLSDYDSSEEAIRTLDQISDADNIPGL--LVLKSLAYRN 398

Query: 1283 LGQYGFALEDFKQAALISRTNGSLCHAT-AMCHHRINEFEEAVNFFTWALKINPCFLDAY 1341
             G +  A +   +  L S  + +  HA  A+ H    ++ +A   F  AL+ +    + +
Sbjct: 399  KGSFDEAAK-IMEDLLSSYPDLAEVHALEALIHFTKKDYLQAEKCFQRALEKDTEVAEYH 457

Query: 1342 VGRGNSYMEYGHD---EATKQAQKDFLKALHINPAYIKARISFGYNLQ--------AQGK 1390
               G +Y   G +   + TK A   FLKA  ++    K     G+  +        A+G 
Sbjct: 458  YQLGLTYWFMGEETRKDKTK-ALTHFLKAARLDTYMGKVFCYLGHYYRDVVGDKNRARGC 516

Query: 1391 FQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGV 1450
            ++KA+       DTD ++  A    +V    M    A +  +       T       RG+
Sbjct: 517  YRKAFE----LDDTDAESGAAAVDLSVELEDMEMALAILTTVTQKASAGTAKWAWLRRGL 572

Query: 1451 IHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENE 1510
             +   G    A+ D Q A+  +PK    + + G  Y     ++ A   F+KA + +PE+ 
Sbjct: 573  YYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKASELNPESI 632

Query: 1511 YVLMNRAITNTILKKYEEAKEDFANVIE 1538
            Y +   A    IL KY+EA   +  +I+
Sbjct: 633  YSVFKVAAIQQILGKYKEAVAQYQMIIK 660



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 100/521 (19%), Positives = 187/521 (35%), Gaps = 82/521 (15%)

Query: 918  FAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYI 977
            +A+ RRG  Y K G+   A+ DLQ  +  +P   N +      YL +     AL      
Sbjct: 565  WAWLRRGLYYLKAGQHSQAVADLQAALRADPKDFNCWESLGEAYLSRGGYTTALKSFTKA 624

Query: 978  HKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNKVLA 1037
             + N  +  +    A I +       A+  Y   IK            GE + +  K   
Sbjct: 625  SELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIKKKEDYVPALKGLGECHLMMAKAAL 684

Query: 1038 IDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMK 1097
            +D      + D K  D + K             A+E FT  L       Q R     + K
Sbjct: 685  VD------YLDGKAVDYIEK-------------ALEYFTCAL-------QHRADVSCLWK 718

Query: 1098 YYDLAKFTIYQIAEMDKGLSELSPM-----------QQALIYSFCENHDKAIEVLD---- 1142
                A   +Y +A     +  L  +           +  L++     + +A++++     
Sbjct: 719  LAGDACTCLYAVAPSKVNVHVLGVLLGQKEGKQVLKKNELLHLGGRCYGRALKLMSTSNT 778

Query: 1143 ----GISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISADCL 1198
                GI++ R    +    + +    +  ++++  LKKA+   S++    +A  + A   
Sbjct: 779  WCDLGINYYRQAQHLAETGSNMNDLKELLEKSLHCLKKAVRLDSNNHLYWNALGVVA--- 835

Query: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGI 1258
                 CY   GN    Y LA      +I  ++ +  A+ N  + Y     ++ A   + +
Sbjct: 836  -----CYSGIGN----YALAQHCFIKSIQSEQINAVAWTNLGVLYLTNENIEQAHEAFKM 886

Query: 1259 VLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAA-LISRTNGSLCHATAMCHHRI 1317
               LD +    L  ++ + LI   +G Y   ++ F+    L   T G+L +A  +C    
Sbjct: 887  AQSLDPS---YLMCWIGQALIAEAVGSYD-TMDLFRHTTELNMHTEGALGYAYWVCTTLQ 942

Query: 1318 NEFEEAVNFFTW------ALKINPCFLDAYVGRGNSYME--------YGHDEATKQAQKD 1363
            ++       + +      A+      L+ YV R  +Y            H +  K+A   
Sbjct: 943  DKSNRETELYQYNILQMNAIPAAQVILNKYVERIQNYAPAFTMLGYLNEHLQLKKEAANA 1002

Query: 1364 FLKALHI------NPAYIKARISFGYNLQAQGKFQKAWNHF 1398
            + +A+ +         Y  A  ++G  L + G++ KA   F
Sbjct: 1003 YQRAILLLQTAEDQDTYNVAIRNYGRLLCSTGEYDKAIQAF 1043



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 3/137 (2%)

Query: 1213 MTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNT 1272
            M   LAI    T  +    +  A+  R L Y K  +   A+ D    L  D  +    N 
Sbjct: 544  MEMALAILTTVTQKASAGTAKWAWLRRGLYYLKAGQHSQAVADLQAALRADPKD---FNC 600

Query: 1273 FLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332
            + + G  Y+  G Y  AL+ F +A+ ++  +       A     + +++EAV  +   +K
Sbjct: 601  WESLGEAYLSRGGYTTALKSFTKASELNPESIYSVFKVAAIQQILGKYKEAVAQYQMIIK 660

Query: 1333 INPCFLDAYVGRGNSYM 1349
                ++ A  G G  ++
Sbjct: 661  KKEDYVPALKGLGECHL 677


>gi|21450645 tetratricopeptide repeat domain 16 [Homo sapiens]
          Length = 873

 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 74/321 (23%), Positives = 134/321 (41%), Gaps = 34/321 (10%)

Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
            ++E AV  F+ AL ++P  +D Y  R  +Y++     +  Q  +        N  +++ R
Sbjct: 76   DWETAVLLFSRALHLDPQLVDFYALRAEAYLQLCDFSSAAQNLRRAYSLQQDNCKHLE-R 134

Query: 1379 ISFGYNLQAQGKFQK-----AWNHFTIAIDTDPKNYLAYEGRAVVC-LQMGNNFAAMQDI 1432
            ++F   LQ Q  F++     A N F+ A +  P+    +  R + C L +  + A +  I
Sbjct: 135  LTFVLYLQGQCLFEQCAFLDALNVFSHAAELQPEK-PCFRYRCMACLLALKQHQACLTLI 193

Query: 1433 NAAMKISTT-AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQ 1491
               +K  TT A+    R  ++ F+       +D   A+ LNPK+  A      +    +Q
Sbjct: 194  TNELKQDTTNADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQAQQ 253

Query: 1492 FSQ-------------ASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIE 1538
              Q             A    ++A++ +P +  + + R      L++++ A EDF  V++
Sbjct: 254  ARQDAGILAVQGKLQHALQRINRAIENNPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVLD 313

Query: 1539 SCPFWAAVYFNRAH----------FYYCLKQ--YELAEEDLNKALSLKPNDALVYNFRAK 1586
                       +A             +C +Q  Y+     LNKAL  +  +  +Y  R  
Sbjct: 314  MVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGD 373

Query: 1587 VRGKIGLIEEAMADYNQALDL 1607
               ++G +  A ADY QAL L
Sbjct: 374  CFFQLGNLAFAEADYQQALAL 394



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 103/500 (20%), Positives = 181/500 (36%), Gaps = 101/500 (20%)

Query: 1049 PKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYLLMMKYYDLAKFTIYQ 1108
            P +      RG    E  +W  A+  F+  L++D Q          ++ +Y L      Q
Sbjct: 58   PLKVREYYSRGQQCLEQADWETAVLLFSRALHLDPQ----------LVDFYALRAEAYLQ 107

Query: 1109 IAEMDKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAE--MTMCALLAKVQMKAKR 1166
            + +       L        YS  +++ K +E L  + + + +     CA L         
Sbjct: 108  LCDFSSAAQNLRRA-----YSLQQDNCKHLERLTFVLYLQGQCLFEQCAFL--------- 153

Query: 1167 TKEAVEVLKKALDAISHS-DKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTA 1225
                      AL+  SH+ +  P+       C+     C +        ++  +T +T  
Sbjct: 154  ---------DALNVFSHAAELQPEKPCFRYRCM----ACLLA----LKQHQACLTLITNE 196

Query: 1226 ISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQ 1285
            +  D  +   +  RA  Y  +++  +   D    LLL+            R L+   + Q
Sbjct: 197  LKQDTTNADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQA------RMLLQKMVAQ 250

Query: 1286 YGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRG 1345
                 +  +Q A I    G L HA      RIN           A++ NP     ++ RG
Sbjct: 251  ----AQQARQDAGILAVQGKLQHAL----QRINR----------AIENNPLDPSLFLFRG 292

Query: 1346 NSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTD 1405
              Y      +    A +DFLK L +     +  +      QAQ +    +N F       
Sbjct: 293  TMYRRLQEFDG---AVEDFLKVLDMVTEDQEDMVR-----QAQRQLLLTYNDF------- 337

Query: 1406 PKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFL-TNRGVIHEFMGHKQNAMKD 1464
                      AV C + G     +  +N A++     + L  NRG     +G+   A  D
Sbjct: 338  ----------AVHCYRQGAYQEGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFAEAD 387

Query: 1465 YQDAITLNP-------KYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA 1517
            YQ A+ L+P       +  L     G      +QF +A ++FS A++ +P+     + RA
Sbjct: 388  YQQALALSPQDEGANTRMGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRA 447

Query: 1518 ITNTILKKYEEAKEDFANVI 1537
             +  +L+    A++D A V+
Sbjct: 448  KSRQLLQNIFGARQDVATVL 467



 Score = 50.1 bits (118), Expect = 2e-05
 Identities = 48/186 (25%), Positives = 81/186 (43%), Gaps = 22/186 (11%)

Query: 1273 FLNRGLIYVELGQYGFALEDF---------KQAALISRTNGSLC---HATAMCHHRINEF 1320
            FL RG +Y  L ++  A+EDF          Q  ++ +    L    +  A+  +R   +
Sbjct: 288  FLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAY 347

Query: 1321 EEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARIS 1380
            +E V     AL+        Y+ RG+ + + G+      A+ D+ +AL ++P    A   
Sbjct: 348  QEGVLLLNKALRDEQQEKGLYINRGDCFFQLGN---LAFAEADYQQALALSPQDEGANTR 404

Query: 1381 FGYNLQAQG-------KFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDIN 1433
             G   +  G       +FQKA NHF+ AI  +P+    Y  RA     + N F A QD+ 
Sbjct: 405  MGLLQEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKSRQLLQNIFGARQDVA 464

Query: 1434 AAMKIS 1439
              + ++
Sbjct: 465  TVLLLN 470



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 45/204 (22%), Positives = 71/204 (34%), Gaps = 26/204 (12%)

Query: 1372 PAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQD 1431
            P  ++   S G     Q  ++ A   F+ A+  DP+    Y  RA   LQ+ +  +A Q+
Sbjct: 58   PLKVREYYSRGQQCLEQADWETAVLLFSRALHLDPQLVDFYALRAEAYLQLCDFSSAAQN 117

Query: 1432 INAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQ 1491
            +  A  +                           QD      + +   +  G   F    
Sbjct: 118  LRRAYSLQ--------------------------QDNCKHLERLTFVLYLQGQCLFEQCA 151

Query: 1492 FSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRA 1551
            F  A + FS A +  PE              LK+++       N ++     A VY  RA
Sbjct: 152  FLDALNVFSHAAELQPEKPCFRYRCMACLLALKQHQACLTLITNELKQDTTNADVYIFRA 211

Query: 1552 HFYYCLKQYELAEEDLNKALSLKP 1575
              Y  L++  L   DL+ AL L P
Sbjct: 212  RLYNFLQKPHLCYRDLHSALLLNP 235



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 74/402 (18%), Positives = 144/402 (35%), Gaps = 50/402 (12%)

Query: 1212 QMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDY--GIVLLLDATETVK 1269
            Q  ++ A+   + A+ +D      +  RA  Y ++ +   A  +      L  D  + ++
Sbjct: 74   QADWETAVLLFSRALHLDPQLVDFYALRAEAYLQLCDFSSAAQNLRRAYSLQQDNCKHLE 133

Query: 1270 LNTFLN--RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFF 1327
              TF+   +G    E   +  AL  F  AA +        +    C   + + +  +   
Sbjct: 134  RLTFVLYLQGQCLFEQCAFLDALNVFSHAAELQPEKPCFRYRCMACLLALKQHQACLTLI 193

Query: 1328 TWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYN--- 1384
            T  LK +    D Y+ R   Y      +      +D   AL +NP + +AR+        
Sbjct: 194  TNELKQDTTNADVYIFRARLY---NFLQKPHLCYRDLHSALLLNPKHPQARMLLQKMVAQ 250

Query: 1385 ----------LQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINA 1434
                      L  QGK Q A      AI+ +P +   +       L  G  +  +Q+ + 
Sbjct: 251  AQQARQDAGILAVQGKLQHALQRINRAIENNPLDPSLF-------LFRGTMYRRLQEFD- 302

Query: 1435 AMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHR-QFS 1493
                          G + +F+       +D +D +    +  L  +N   ++ + +  + 
Sbjct: 303  --------------GAVEDFLKVLDMVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAYQ 348

Query: 1494 QASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFN---- 1549
            +     +KAL+ + + + + +NR      L     A+ D+   +   P            
Sbjct: 349  EGVLLLNKALRDEQQEKGLYINRGDCFFQLGNLAFAEADYQQALALSPQDEGANTRMGLL 408

Query: 1550 RAHFYYC---LKQYELAEEDLNKALSLKPNDALVYNFRAKVR 1588
            +    +C    KQ++ AE   + A+   P  A  Y +RAK R
Sbjct: 409  QEKMGFCEQRRKQFQKAENHFSTAIRHNPQKAQYYLYRAKSR 450



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 36/152 (23%), Positives = 61/152 (40%), Gaps = 23/152 (15%)

Query: 895  IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954
            +K +++ + ++T E+   T   A  Y  R  +Y  L K      DL   +LL P    A 
Sbjct: 183  LKQHQACLTLITNELKQDTTN-ADVYIFRARLYNFLQKPHLCYRDLHSALLLNPKHPQA- 240

Query: 955  WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKS 1014
              R L+     +  +A  D   +                  +GK    L  +N  +AI++
Sbjct: 241  --RMLLQKMVAQAQQARQDAGIL----------------AVQGKLQHALQRIN--RAIEN 280

Query: 1015 TPTDADIYFRRGEMYEITNKV-LAIDDFSKCI 1045
             P D  ++  RG MY    +   A++DF K +
Sbjct: 281  NPLDPSLFLFRGTMYRRLQEFDGAVEDFLKVL 312


>gi|221219056 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 2
            [Homo sapiens]
          Length = 438

 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 85/361 (23%), Positives = 138/361 (38%), Gaps = 57/361 (15%)

Query: 1275 NRGLIYVELGQYGFALEDFKQAALI--SRTNGSLCHATAMCHHRINEFEEAVNFFTWALK 1332
            NR    + LG++  AL D +Q+  +  S   G L      CH  +     A   F  AL+
Sbjct: 11   NRAATLMMLGRFREALGDAQQSVRLDDSFVRGHL--REGKCHLSLGNAMAACRSFQRALE 68

Query: 1333 INPCFLDAY--VGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGK 1390
            ++     A       N+ MEY     T   ++DF K +              + +    +
Sbjct: 69   LDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVV--------------FCMDRALE 114

Query: 1391 FQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGV 1450
            F  A + F I         LA  GR      + ++   M         ST A+ L  RG+
Sbjct: 115  FAPACHRFKIL----KAECLAMLGRYPEAQSVASDILRMD--------STNADALYVRGL 162

Query: 1451 IHEFMGHKQNAMKDYQDAITLNP---KYSLAYFNA---------GNIYFHHRQFSQASDY 1498
               +    + A++ +  A+ + P   K  +A  NA         GN  F    +  A + 
Sbjct: 163  CLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYEL 222

Query: 1499 FSKALKFDPEN----EYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHFY 1554
            +++AL  DP N      +  NR   N+ L+K ++A ED  N ++    +   Y  RA  Y
Sbjct: 223  YTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCY 282

Query: 1555 YCLKQYELAEEDLNKAL---SLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLEDYA 1611
               +QYE A  D  K       K +  L+ N       ++ L +    DY + L ++  A
Sbjct: 283  MDTEQYEEAVRDYEKVYQTEKTKEHKQLLKN------AQLELKKSKRKDYYKILGVDKNA 336

Query: 1612 S 1612
            S
Sbjct: 337  S 337



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 73/312 (23%), Positives = 126/312 (40%), Gaps = 35/312 (11%)

Query: 1016 PTDADIYFRRGEMYEITNKVL-AIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIED 1074
            P +A  Y  R     +  +   A+ D  + +  D       L+ G  +    N  AA   
Sbjct: 3    PKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRS 62

Query: 1075 FTALLNIDHQNSQARGQYL---LMMKYYDLAKFTIYQ------IAEMDKGLSELSPMQQ- 1124
            F   L +DH+N+QA+ ++     +M+Y  +A+    +      +  MD+ L E +P    
Sbjct: 63   FQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRAL-EFAPACHR 121

Query: 1125 ---------ALIYSFCENHDKAIEVLDGISWNRAEMTMCAL-LAKVQMKAKRTKEAVEVL 1174
                     A++  + E    A ++L   S N   + +  L L       K  +  V+ L
Sbjct: 122  FKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQAL 181

Query: 1175 KKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYT 1234
            + A D         +A A+ A      G    +EGN    YKLA    T A+ +D N+  
Sbjct: 182  RMAPDHEKACIACRNAKALKAK--KEDGNKAFKEGN----YKLAYELYTEALGIDPNNIK 235

Query: 1235 A----FYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFAL 1290
                 + NR    +K+R+L  A+ D    + LD T    +  +L R   Y++  QY  A+
Sbjct: 236  TNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDT---YIKAYLRRAQCYMDTEQYEEAV 292

Query: 1291 EDFKQAALISRT 1302
             D+++     +T
Sbjct: 293  RDYEKVYQTEKT 304



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 26/97 (26%), Positives = 44/97 (45%), Gaps = 3/97 (3%)

Query: 898 YESEVKILTEEIN---DKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954
           Y+   ++ TE +    +  K  A  YC RG +  KL KL  A+ D    + L+  ++ AY
Sbjct: 216 YKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAY 275

Query: 955 WHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLSK 991
             R   Y+  ++  EA+ D   +++  K      L K
Sbjct: 276 LRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLK 312


>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
            [Homo sapiens]
          Length = 836

 Score = 55.1 bits (131), Expect = 5e-07
 Identities = 64/282 (22%), Positives = 109/282 (38%), Gaps = 28/282 (9%)

Query: 1318 NEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK- 1376
            + F EA++++  A+   P    AY+  G   M  G    T++A++ FLK   I    +K 
Sbjct: 541  SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGR---TEEARRTFLKCSEIPDENLKD 597

Query: 1377 ------ARISFGYNL----QAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
                  +  S  YNL      QG +++A + +  AI   P+ +        +   MG  +
Sbjct: 598  PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQS----LYNMMGEAY 653

Query: 1427 AAMQDINAA---------MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSL 1477
              +  +  A          K       LT  G +    G K  A K +  AI L+P    
Sbjct: 654  MRLSKLPEAEHWYMESLRSKTDHIPAHLTY-GKLLALTGRKSEAEKLFLKAIELDPTKGN 712

Query: 1478 AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVI 1537
             Y + G       +  +A++   KA + D     V+ N A         E A++ +    
Sbjct: 713  CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772

Query: 1538 ESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
               P + A   N     +   + + AE +  +AL LKP+D +
Sbjct: 773  RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVI 814



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 72/289 (24%), Positives = 117/289 (40%), Gaps = 15/289 (5%)

Query: 1195 ADCLYNLGLCYMEEGNLQMT---YKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQM 1251
            AD LYNLGL   E          YKLAI    T  S   N+     N+     + R   +
Sbjct: 527  ADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRT-EEARRTFL 585

Query: 1252 ALTDYGIVLLLD--ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN---GSL 1306
              ++     L D  A ++   +   N G +Y E G Y  AL  +K+A           SL
Sbjct: 586  KCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSL 645

Query: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
             +     + R+++  EA +++  +L+     + A++  G      G      +A+K FLK
Sbjct: 646  YNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGR---KSEAEKLFLK 702

Query: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
            A+ ++P      + +G  L  + +  +A      A + D   +      A +  Q   N 
Sbjct: 703  AIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNE 762

Query: 1427 AAMQ--DINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473
            AA +  D+ A ++ +  A  L N G I    G  Q A  +Y  A+ L P
Sbjct: 763  AAEKYYDLAARLRPNYPAA-LMNLGAILHLNGRLQKAEANYLRALQLKP 810



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 67/316 (21%), Positives = 118/316 (37%), Gaps = 21/316 (6%)

Query: 1225 AISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELG 1284
            A+    N     YN  L   +      AL  Y + +    +     + +LN G+I +  G
Sbjct: 519  ALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAI---GSRPTLASAYLNTGIILMNQG 575

Query: 1285 QYGFALEDFKQAALISRTNGSLCHA-----------TAMCHHRINEFEEAVNFFTWALKI 1333
            +   A   F + + I   N    HA               +H    +EEA++ +  A++ 
Sbjct: 576  RTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635

Query: 1334 NPCFL---DAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGK 1390
             P        Y   G +YM         +A+  ++++L     +I A +++G  L   G+
Sbjct: 636  MPRQFAPQSLYNMMGEAYMRLSK---LPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGR 692

Query: 1391 FQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKI-STTAEFLTNRG 1449
              +A   F  AI+ DP     Y       L+      A +    A ++ ST  + + N  
Sbjct: 693  KSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAA 752

Query: 1450 VIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPEN 1509
             +       + A K Y  A  L P Y  A  N G I   + +  +A   + +AL+  P++
Sbjct: 753  HMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDD 812

Query: 1510 EYVLMNRAITNTILKK 1525
                 N      I++K
Sbjct: 813  VITQSNLRKLWNIMEK 828



 Score = 42.4 bits (98), Expect = 0.004
 Identities = 61/262 (23%), Positives = 103/262 (39%), Gaps = 28/262 (10%)

Query: 1160 VQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISA-DCLYNLGLCYMEEGNLQMTYKLA 1218
            + M   RT+EA     K  +    + K P A   S   CLYNLG  Y E+G+    Y+ A
Sbjct: 570  ILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH----YEEA 625

Query: 1219 ITDLTTAISMDKNSYT--AFYN-RALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
            ++    AI      +   + YN     Y ++ +L  A   Y   L    ++T  +   L 
Sbjct: 626  LSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL---RSKTDHIPAHLT 682

Query: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFT 1328
             G +    G+   A + F +A  +  T G+       C+    +F        EA     
Sbjct: 683  YGKLLALTGRKSEAEKLFLKAIELDPTKGN-------CYMHYGQFLLEEARLIEAAEMAK 735

Query: 1329 WALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQ 1388
             A +++    D      +   +   +EA   A+K +  A  + P Y  A ++ G  L   
Sbjct: 736  KAAELDSTEFDVVFNAAHMLRQASLNEA---AEKYYDLAARLRPNYPAALMNLGAILHLN 792

Query: 1389 GKFQKAWNHFTIAIDTDPKNYL 1410
            G+ QKA  ++  A+   P + +
Sbjct: 793  GRLQKAEANYLRALQLKPDDVI 814



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 61/267 (22%), Positives = 100/267 (37%), Gaps = 21/267 (7%)

Query: 1359 QAQKDFLKALHINPAYIKARISFGYNLQA---QGKFQKAWNHFTIAIDTDPKNYLAYEGR 1415
            + QK FLK+L     Y  A +   Y L+     G +Q     +   I  +P       G 
Sbjct: 445  KVQKRFLKSLIF---YATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGN 501

Query: 1416 AVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKY 1475
             V+  Q   + A     NA    S  A+ L N G++ +       A+  Y+ AI   P  
Sbjct: 502  -VLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTL 560

Query: 1476 SLAYFNAGNIYFHHRQFSQASDYFSKALKFDPEN--EYVLMNRAITNTILK--------- 1524
            + AY N G I  +  +  +A   F K  +   EN  +      ++T+ +           
Sbjct: 561  ASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG 620

Query: 1525 KYEEAKEDFANVIESCPFWAA---VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
             YEEA   +   I+  P   A   +Y      Y  L +   AE    ++L  K +    +
Sbjct: 621  HYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAH 680

Query: 1582 NFRAKVRGKIGLIEEAMADYNQALDLE 1608
                K+    G   EA   + +A++L+
Sbjct: 681  LTYGKLLALTGRKSEAEKLFLKAIELD 707


>gi|5453980 DnaJ (Hsp40) homolog, subfamily C, member 3 [Homo sapiens]
          Length = 504

 Score = 53.5 bits (127), Expect = 2e-06
 Identities = 57/238 (23%), Positives = 100/238 (42%), Gaps = 22/238 (9%)

Query: 1373 AYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNFAAMQDI 1432
            A ++  +  G  L A G+   A + F  A+D DP NY+AY  RA V L MG + AA+ D+
Sbjct: 35   ADVEKHLELGKKLLAAGQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDL 94

Query: 1433 NAA--MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHR 1490
                 +K+  TA  L  RG +    G    A  D++  +  NP                 
Sbjct: 95   TKVIQLKMDFTAARL-QRGHLLLKQGKLDEAEDDFKKVLKSNPSE--------------- 138

Query: 1491 QFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNR 1550
              ++  +  S+ +K D      L ++A+       Y  A      ++E C + A +   R
Sbjct: 139  --NEEKEAQSQLIKSDEMQR--LRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRELR 194

Query: 1551 AHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
            A  +    +   A  DL  A  LK ++   +   + +  ++G  E ++++  + L L+
Sbjct: 195  AECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLD 252



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 45/195 (23%), Positives = 81/195 (41%), Gaps = 16/195 (8%)

Query: 919  AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978
            AY RR  ++  +GK ++A+ DL +VI L+  F  A   R  + L Q K++EA DD   + 
Sbjct: 73   AYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQRGHLLLKQGKLDEAEDDFKKVL 132

Query: 979  KYNKNNTEAYLSKAEIYR---------------GKKDITLAILNYTQAIKSTPTDADIYF 1023
            K N +  E   +++++ +               G  D T AI    + ++    DA++  
Sbjct: 133  KSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDYTAAIAFLDKILEVCVWDAELRE 192

Query: 1024 RRGEMY-EITNKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNID 1082
             R E + +      AI D           T+A  K    Y +  +   ++ +    L +D
Sbjct: 193  LRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKISTLYYQLGDHELSLSEVRECLKLD 252

Query: 1083 HQNSQARGQYLLMMK 1097
              + +    Y  + K
Sbjct: 253  QDHKRCFAHYKQVKK 267



 Score = 40.0 bits (92), Expect = 0.018
 Identities = 58/318 (18%), Positives = 123/318 (38%), Gaps = 35/318 (11%)

Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
            +  +A++ F  A+  +P    AY  R   ++  G  +A   A  D  K + +   +  AR
Sbjct: 52   QLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKA---ALPDLTKVIQLKMDFTAAR 108

Query: 1379 ISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYE---------------GRAVVCLQMG 1423
            +  G+ L  QGK  +A + F   + ++P      E                +A+     G
Sbjct: 109  LQRGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSG 168

Query: 1424 NNFAAMQDINAAMKIST-TAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNA 1482
            +  AA+  ++  +++    AE    R       G  + A+ D + A  L    + A++  
Sbjct: 169  DYTAAIAFLDKILEVCVWDAELRELRAECFIKEGEPRKAISDLKAASKLKNDNTEAFYKI 228

Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILK------------KYEEAK 1530
              +Y+       +     + LK D +++    +      + K            +Y +A 
Sbjct: 229  STLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDAT 288

Query: 1531 EDFANVIESCPFWAA-VYFNRAHFYYCLKQYELAEEDL---NKALSLKPNDALVYNFRAK 1586
              + +V+++ P  A     ++    +C  + E   E +   ++ L ++P++      RA+
Sbjct: 289  SKYESVMKTEPSIAEYTVRSKERICHCFSKDEKPVEAIRVCSEVLQMEPDNVNALKDRAE 348

Query: 1587 VRGKIGLIEEAMADYNQA 1604
                  + +EA+ DY  A
Sbjct: 349  AYLIEEMYDEAIQDYETA 366



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 43/195 (22%), Positives = 82/195 (42%), Gaps = 26/195 (13%)

Query: 1180 AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNR 1239
            AI+  DK  +     A+       C+++EG  +     AI+DL  A  +  ++  AFY  
Sbjct: 173  AIAFLDKILEVCVWDAELRELRAECFIKEGEPRK----AISDLKAASKLKNDNTEAFYKI 228

Query: 1240 ALCYTKIRELQMALTDYGIVLLLDA---------TETVKLNTFLNRGLIYVELGQYGFAL 1290
            +  Y ++ + +++L++    L LD           +  KLN  +      +  G+Y  A 
Sbjct: 229  STLYYQLGDHELSLSEVRECLKLDQDHKRCFAHYKQVKKLNKLIESAEELIRDGRYTDAT 288

Query: 1291 EDFKQ--------AALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
              ++         A    R+   +CH    C  +  +  EA+   +  L++ P  ++A  
Sbjct: 289  SKYESVMKTEPSIAEYTVRSKERICH----CFSKDEKPVEAIRVCSEVLQMEPDNVNALK 344

Query: 1343 GRGNSYM-EYGHDEA 1356
             R  +Y+ E  +DEA
Sbjct: 345  DRAEAYLIEEMYDEA 359



 Score = 32.7 bits (73), Expect = 2.9
 Identities = 42/206 (20%), Positives = 84/206 (40%), Gaps = 28/206 (13%)

Query: 931  GKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHKYNKNNTEAYLS 990
            G+L  A++     +  +P    AY+ R  ++L   K   AL DL  + +   + T A L 
Sbjct: 51   GQLADALSQFHAAVDGDPDNYIAYYRRATVFLAMGKSKAALPDLTKVIQLKMDFTAARLQ 110

Query: 991  KAEIYRGKKDITLAILNYTQAIKSTPTDAD------IYFRRGEMYEITNKVL---AIDDF 1041
            +  +   +  +  A  ++ + +KS P++ +         +  EM  + ++ L      D+
Sbjct: 111  RGHLLLKQGKLDEAEDDFKKVLKSNPSENEEKEAQSQLIKSDEMQRLRSQALNAFGSGDY 170

Query: 1042 SKCIFYDPKRTDAL--------LKRGLFYCENENWFAAIEDFTALLNIDHQNSQARGQYL 1093
            +  I +  K  +          L+   F  E E    AI D  A   + + N++A     
Sbjct: 171  TAAIAFLDKILEVCVWDAELRELRAECFIKEGEP-RKAISDLKAASKLKNDNTEA----- 224

Query: 1094 LMMKYYDLAKFTIYQIAEMDKGLSEL 1119
                +Y ++    YQ+ + +  LSE+
Sbjct: 225  ----FYKISTL-YYQLGDHELSLSEV 245


>gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing
            protein) [Homo sapiens]
          Length = 543

 Score = 52.8 bits (125), Expect = 3e-06
 Identities = 50/228 (21%), Positives = 95/228 (41%), Gaps = 4/228 (1%)

Query: 1350 EYGHDEATKQ----AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTD 1405
            E G+D   K+    A K + KA  ++P  +    +       +G + K       AI+  
Sbjct: 230  ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289

Query: 1406 PKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDY 1465
             +N   Y   A    ++GN++   +    A+     +        + +     +  +K+ 
Sbjct: 290  RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQ 349

Query: 1466 QDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525
            +    +NP  +L   N GN  F    + QA  ++++A+K +P++  +  NRA   T L +
Sbjct: 350  ERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409

Query: 1526 YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSL 1573
            ++ A +D    I+  P +   Y  +A     +K Y  A +   KAL L
Sbjct: 410  FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDL 457



 Score = 48.5 bits (114), Expect = 5e-05
 Identities = 52/229 (22%), Positives = 95/229 (41%), Gaps = 41/229 (17%)

Query: 1421 QMGNNFAAMQDINAAMKI--------STTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLN 1472
            ++GN+    +D + A+K          T   ++TN+  ++   G      +  + AI + 
Sbjct: 230  ELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVG 289

Query: 1473 PK-------YSLAYFNAGNIYFHHRQFSQASDYFSKAL----------------KFDPEN 1509
             +        + AY   GN YF   ++  A  +++K+L                K   E 
Sbjct: 290  RENREDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQ 349

Query: 1510 E---YVLMNRAIT-----NTILKK--YEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQ 1559
            E   Y+  + A+      N   +K  Y +A + +   I+  P  A +Y NRA  Y  L +
Sbjct: 350  ERLAYINPDLALEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409

Query: 1560 YELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
            ++LA +D  + + L+P     Y  +A     +    +AM  Y +ALDL+
Sbjct: 410  FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLD 458



 Score = 40.8 bits (94), Expect = 0.011
 Identities = 48/188 (25%), Positives = 79/188 (42%), Gaps = 14/188 (7%)

Query: 917  AFAYCRRGAIYRKLGKLQSAMNDLQRVILLE--PLFLNAYWHRHLIYLFQDKINEALDDL 974
            A AY R G  Y K  K + A++   + +     P  L        I   Q+++     DL
Sbjct: 300  AKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDL 359

Query: 975  NYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMY-EITN 1033
                K NK N        E ++ K D   A+ +YT+AIK  P DA +Y  R   Y ++  
Sbjct: 360  ALEEK-NKGN--------ECFQ-KGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLE 409

Query: 1034 KVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQAR-GQY 1092
              LA+ D  +CI  +P       ++       +++  A++ +   L++D    +A  G  
Sbjct: 410  FQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQ 469

Query: 1093 LLMMKYYD 1100
              MM  Y+
Sbjct: 470  RCMMAQYN 477



 Score = 40.4 bits (93), Expect = 0.014
 Identities = 24/95 (25%), Positives = 40/95 (42%)

Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
            GN          A   +S+A+K DP N  +  NR+        Y++A ED    ++  P 
Sbjct: 11   GNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPD 70

Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPND 1577
            W   Y  +A     L ++E A+    + L  + N+
Sbjct: 71   WGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANN 105



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 1/57 (1%)

Query: 898 YESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAY 954
           Y   +K  TE I    K  A  Y  R A Y KL + Q A+ D +  I LEP F+  Y
Sbjct: 376 YPQAMKHYTEAIKRNPK-DAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGY 431



 Score = 35.8 bits (81), Expect = 0.34
 Identities = 19/51 (37%), Positives = 26/51 (50%)

Query: 1215 YKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDAT 1265
            Y  A+   T AI  +      + NRA CYTK+ E Q+AL D    + L+ T
Sbjct: 376  YPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPT 426



 Score = 35.4 bits (80), Expect = 0.45
 Identities = 56/266 (21%), Positives = 97/266 (36%), Gaps = 26/266 (9%)

Query: 1175 KKALD-AISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSY 1233
            KK  D A+ H DK  +    +   + N    Y E+G+     +L       AI + + + 
Sbjct: 238  KKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELC----EKAIEVGRENR 293

Query: 1234 TAFYNRALCYTKI-------RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQY 1286
              +   A  Y +I        + + A+  Y   L    T  V L        I  E  + 
Sbjct: 294  EDYRQIAKAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDV-LKKCQQAEKILKEQERL 352

Query: 1287 GFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGN 1346
             +   D    AL  +  G+ C           ++ +A+  +T A+K NP     Y  R  
Sbjct: 353  AYINPDL---ALEEKNKGNECFQKG-------DYPQAMKHYTEAIKRNPKDAKLYSNRAA 402

Query: 1347 SYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDP 1406
             Y +    +    A KD  + + + P +IK        L+A   + KA + +  A+D D 
Sbjct: 403  CYTKLLEFQL---ALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDS 459

Query: 1407 KNYLAYEGRAVVCLQMGNNFAAMQDI 1432
                A +G     +   N   + +D+
Sbjct: 460  SCKEAADGYQRCMMAQYNRHDSPEDV 485



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 23/82 (28%), Positives = 38/82 (46%)

Query: 1527 EEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAK 1586
            ++A + ++  I+  P    +Y NR+  Y     Y+ A ED  K + LKP+    Y+ +A 
Sbjct: 21   DDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYSRKAA 80

Query: 1587 VRGKIGLIEEAMADYNQALDLE 1608
                +   EEA   Y + L  E
Sbjct: 81   ALEFLNRFEEAKRTYEEGLKHE 102



 Score = 33.1 bits (74), Expect = 2.2
 Identities = 19/79 (24%), Positives = 36/79 (45%)

Query: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM 1514
            +G+  +A++ Y +AI L+P   + Y N    Y     + +A +   K +   P+      
Sbjct: 17   VGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGYS 76

Query: 1515 NRAITNTILKKYEEAKEDF 1533
             +A     L ++EEAK  +
Sbjct: 77   RKAAALEFLNRFEEAKRTY 95


>gi|24308141 small glutamine-rich tetratricopeptide repeat
            (TPR)-containing, beta [Homo sapiens]
          Length = 304

 Score = 52.0 bits (123), Expect = 5e-06
 Identities = 36/120 (30%), Positives = 53/120 (44%), Gaps = 8/120 (6%)

Query: 1414 GRAVVCLQMGNNFAAMQDINAAMKIST--------TAEFLTNRGVIHEFMGHKQNAMKDY 1465
            G+A      GNN    ++  AA+   T         A +  NR      +GH  +A+KD 
Sbjct: 83   GKADQLKDEGNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDC 142

Query: 1466 QDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525
            + AI ++ KYS AY   G       +F +A   + KAL  DPEN+    N  I    L++
Sbjct: 143  EKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLKIAEQKLRE 202



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 44/159 (27%), Positives = 67/159 (42%), Gaps = 14/159 (8%)

Query: 1314 HHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPA 1373
            H +   +  AV+ +T A++++P     Y  R  +  + GH      A KD  KA+ I+  
Sbjct: 95   HMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGH---YTDAIKDCEKAIAIDSK 151

Query: 1374 YIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQ----------MG 1423
            Y KA    G  L A  KF++A   +  A+D DP+N  +Y+    +  Q           G
Sbjct: 152  YSKAYGRMGLALTALNKFEEAVTSYQKALDLDPEND-SYKSNLKIAEQKLREVSSPTGTG 210

Query: 1424 NNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAM 1462
             +F     IN    IS  A  + N  V     G   NA+
Sbjct: 211  LSFDMASLINNPAFISMAASLMQNPQVQQLMSGMMTNAI 249



 Score = 42.7 bits (99), Expect = 0.003
 Identities = 28/103 (27%), Positives = 45/103 (43%), Gaps = 1/103 (0%)

Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
            GN +     ++ A D +++A++ DP N     NRA   + L  Y +A +D    I     
Sbjct: 92   GNNHMKEENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSK 151

Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKP-NDALVYNFR 1584
            ++  Y         L ++E A     KAL L P ND+   N +
Sbjct: 152  YSKAYGRMGLALTALNKFEEAVTSYQKALDLDPENDSYKSNLK 194



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 25/85 (29%), Positives = 37/85 (43%)

Query: 1524 KKYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNF 1583
            + Y  A + +   IE  P  A  Y NRA     L  Y  A +D  KA+++    +  Y  
Sbjct: 99   ENYAAAVDCYTQAIELDPNNAVYYCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGR 158

Query: 1584 RAKVRGKIGLIEEAMADYNQALDLE 1608
                   +   EEA+  Y +ALDL+
Sbjct: 159  MGLALTALNKFEEAVTSYQKALDLD 183



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 35/139 (25%), Positives = 58/139 (41%), Gaps = 7/139 (5%)

Query: 860 KDDKISVPEDPPERVKEPPKLKLNDYVESDLPQEVIKYYESEVKILTEEINDKTKYPAFA 919
           K+D + +    PE V +  +LK  D   + + +E    Y + V   T+ I +     A  
Sbjct: 68  KNDVLPLSNSVPEDVGKADQLK--DEGNNHMKEE---NYAAAVDCYTQAI-ELDPNNAVY 121

Query: 920 YCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIHK 979
           YC R A   KLG    A+ D ++ I ++  +  AY    L     +K  EA+        
Sbjct: 122 YCNRAAAQSKLGHYTDAIKDCEKAIAIDSKYSKAYGRMGLALTALNKFEEAVTSYQKALD 181

Query: 980 YNKNNTEAYLSKAEIYRGK 998
            +  N ++Y S  +I   K
Sbjct: 182 LDPEN-DSYKSNLKIAEQK 199



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 37/164 (22%), Positives = 69/164 (42%), Gaps = 12/164 (7%)

Query: 1179 DAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYN 1238
            D +  S+  P+     AD L + G  +M+E N    Y  A+   T AI +D N+   + N
Sbjct: 70   DVLPLSNSVPEDVG-KADQLKDEGNNHMKEEN----YAAAVDCYTQAIELDPNNAVYYCN 124

Query: 1239 RALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAAL 1298
            RA   +K+     A+ D    + +D+  +     +   GL    L ++  A+  +++A  
Sbjct: 125  RAAAQSKLGHYTDAIKDCEKAIAIDSKYS---KAYGRMGLALTALNKFEEAVTSYQKALD 181

Query: 1299 ISRTNGSLCHATAMCHHRINEFEE----AVNFFTWALKINPCFL 1338
            +   N S      +   ++ E        ++F   +L  NP F+
Sbjct: 182  LDPENDSYKSNLKIAEQKLREVSSPTGTGLSFDMASLINNPAFI 225


>gi|225735595 RNA polymerase II associated protein 3 isoform 3 [Homo
            sapiens]
          Length = 506

 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 53/221 (23%), Positives = 92/221 (41%), Gaps = 14/221 (6%)

Query: 1402 IDTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMKISTT-AEFLTNRGVIHEFMGHKQN 1460
            +D DP N +    RA    ++     A  D N A+ ++ +  +  + RG     +   + 
Sbjct: 1    MDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEE 60

Query: 1461 AMKDYQDAITLNP----------KYSLAYFNAGNIYFHHRQFS-QASDYFSKALKFDPEN 1509
            A KDY+  + L P          K S A  +  N Y        ++++   K ++     
Sbjct: 61   AKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNK 120

Query: 1510 EYVLMNRAITNTILK--KYEEAKEDFANVIESCPFWAAVYFNRAHFYYCLKQYELAEEDL 1567
            +  +  +   N   K  KYE A E +   I +    A +  NRA  Y  +++YE AE+D 
Sbjct: 121  QQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDC 180

Query: 1568 NKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQALDLE 1608
             +A+ L  + +  +  R   R  +G + EA  D+   L LE
Sbjct: 181  TQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLE 221



 Score = 45.4 bits (106), Expect = 4e-04
 Identities = 47/232 (20%), Positives = 94/232 (40%), Gaps = 20/232 (8%)

Query: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
            A+ D   A+ +N +Y KA    G    A  K ++A   +   ++ +P             
Sbjct: 27   AESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEP------------- 73

Query: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
                NNF A  ++    KIS       N       +  K    +  Q     N + +++ 
Sbjct: 74   ----NNFEATNELR---KISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISE 126

Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
             + GN +F   ++ +A + +++ +  D  N  +  NRA+    ++KYEEA++D    I  
Sbjct: 127  KDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILL 186

Query: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKI 1591
               ++  +  R      L +   A++D    L L+P +       +K++ ++
Sbjct: 187  DGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKEL 238



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 57/220 (25%), Positives = 96/220 (43%), Gaps = 35/220 (15%)

Query: 919  AYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNYIH 978
            AY RRGA    L KL+ A  D +RV+ LEP   N +              EA ++L  I 
Sbjct: 44   AYSRRGAARFALQKLEEAKKDYERVLELEP---NNF--------------EATNELRKIS 86

Query: 979  KYNKNNTEAYLSKAEIY----RGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEITNK 1034
            +   +   +Y  +A+I      G++    A  N  QAI S     + +F+ G+ YE    
Sbjct: 87   QALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAI-SEKDRGNGFFKEGK-YE---- 140

Query: 1035 VLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDFTALLNIDHQNSQA---RGQ 1091
              AI+ +++ I  D         R + Y + + +  A +D T  + +D   S+A   RG 
Sbjct: 141  -RAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGT 199

Query: 1092 YLLMMKYYDLAKFTIYQIAEMDKG----LSELSPMQQALI 1127
                +   + AK     +  ++ G    ++ELS +++ LI
Sbjct: 200  ARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKELI 239



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 35/136 (25%), Positives = 56/136 (41%), Gaps = 22/136 (16%)

Query: 1168 KEAVEVLKKALDAISHSDKGPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAIS 1227
            ++ +E  +    AIS  D+G                 + +EG     Y+ AI   T  I+
Sbjct: 111  RKQIEAQQNKQQAISEKDRGNG---------------FFKEGK----YERAIECYTRGIA 151

Query: 1228 MDKNSYTAFYNRALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYG 1287
             D  +     NRA+ Y KI++ + A  D    +LLD + +     F  RG     LG+  
Sbjct: 152  ADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYS---KAFARRGTARTFLGKLN 208

Query: 1288 FALEDFKQAALISRTN 1303
             A +DF+   L+   N
Sbjct: 209  EAKQDFETVLLLEPGN 224



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 3/98 (3%)

Query: 1275 NRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKIN 1334
            +RG  + + G+Y  A+E + +       N  L    AM + +I ++EEA    T A+ ++
Sbjct: 128  DRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLD 187

Query: 1335 PCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINP 1372
              +  A+  RG +    G      +A++DF   L + P
Sbjct: 188  GSYSKAFARRGTARTFLG---KLNEAKQDFETVLLLEP 222



 Score = 34.3 bits (77), Expect = 1.0
 Identities = 22/54 (40%), Positives = 27/54 (50%), Gaps = 1/54 (1%)

Query: 895 IKYYESEVKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEP 948
           I+ YE   K  T+ I     Y   A+ RRG     LGKL  A  D + V+LLEP
Sbjct: 170 IQKYEEAEKDCTQAILLDGSYSK-AFARRGTARTFLGKLNEAKQDFETVLLLEP 222


>gi|4506921 small glutamine-rich tetratricopeptide [Homo sapiens]
          Length = 313

 Score = 48.1 bits (113), Expect = 7e-05
 Identities = 30/107 (28%), Positives = 54/107 (50%), Gaps = 1/107 (0%)

Query: 1420 LQMGNNFAAMQDINAAMKIS-TTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLA 1478
            +++ N  AA+     A++++   A +  NR   +  +G+   A++D + AI ++P YS A
Sbjct: 102  MKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKA 161

Query: 1479 YFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKK 1525
            Y   G       +  +A  Y+ KAL+ DP+NE    N  I    L++
Sbjct: 162  YGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLRE 208



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 3/93 (3%)

Query: 1316 RINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYI 1375
            ++  FE AV+F+  A+++NP     +  R  +Y + G+     Q   D  +A+ I+PAY 
Sbjct: 103  KVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQ---DCERAICIDPAYS 159

Query: 1376 KARISFGYNLQAQGKFQKAWNHFTIAIDTDPKN 1408
            KA    G  L +  K  +A  ++  A++ DP N
Sbjct: 160  KAYGRMGLALSSLNKHVEAVAYYKKALELDPDN 192



 Score = 38.5 bits (88), Expect = 0.053
 Identities = 42/160 (26%), Positives = 64/160 (40%), Gaps = 22/160 (13%)

Query: 847 LIEYKDASIPVKEKDDKISVPEDPP---ERVKEPPKLKL--NDYVESDLPQEVIKYYESE 901
           L E  +A+   KE    +  P   P   E   E  +LK   N+ ++ +  +  + +Y   
Sbjct: 58  LPEIFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKA 117

Query: 902 VKILTEEINDKTKYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIY 961
           +     E+N      A  +C R A Y KLG    A+ D +R I ++P +  AY    L  
Sbjct: 118 I-----ELNPAN---AVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLAL 169

Query: 962 LFQDKINEA---------LDDLNYIHKYNKNNTEAYLSKA 992
              +K  EA         LD  N  +K N    E  L +A
Sbjct: 170 SSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLREA 209



 Score = 38.1 bits (87), Expect = 0.069
 Identities = 24/91 (26%), Positives = 42/91 (46%), Gaps = 3/91 (3%)

Query: 1245 KIRELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNG 1304
            K+   + A+  YG  + L+    V    F NR   Y +LG Y  A++D ++A  I     
Sbjct: 103  KVENFEAAVHFYGKAIELNPANAVY---FCNRAAAYSKLGNYAGAVQDCERAICIDPAYS 159

Query: 1305 SLCHATAMCHHRINEFEEAVNFFTWALKINP 1335
                   +    +N+  EAV ++  AL+++P
Sbjct: 160  KAYGRMGLALSSLNKHVEAVAYYKKALELDP 190



 Score = 35.4 bits (80), Expect = 0.45
 Identities = 25/95 (26%), Positives = 38/95 (40%)

Query: 1483 GNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIESCPF 1542
            GN       F  A  ++ KA++ +P N     NRA   + L  Y  A +D    I   P 
Sbjct: 98   GNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPA 157

Query: 1543 WAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPND 1577
            ++  Y         L ++  A     KAL L P++
Sbjct: 158  YSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDN 192


>gi|56606133 tetratricopeptide repeat domain 32 [Homo sapiens]
          Length = 151

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 34/110 (30%), Positives = 49/110 (44%), Gaps = 4/110 (3%)

Query: 1427 AAMQDINAAMKISTT--AEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAYFNAGN 1484
            AA  D +   K S    A    NRG I  F      AM DY  AI + P + + Y+N G 
Sbjct: 41   AASSDESPGSKCSPEDLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGL 100

Query: 1485 IYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFA 1534
            I +    F  A + F K L  +P  +   +  ++  TIL K E+ + + A
Sbjct: 101  ILYRLGYFDDALEDFKKVLDLNPGFQDATL--SLKQTILDKEEKQRRNVA 148



 Score = 37.7 bits (86), Expect = 0.091
 Identities = 18/64 (28%), Positives = 32/64 (50%)

Query: 1544 AAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMADYNQ 1603
            A  Y NR    Y    +  A +D   A+ ++PN  + Y  R  +  ++G  ++A+ D+ +
Sbjct: 58   ATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKK 117

Query: 1604 ALDL 1607
             LDL
Sbjct: 118  VLDL 121



 Score = 37.4 bits (85), Expect = 0.12
 Identities = 20/64 (31%), Positives = 32/64 (50%)

Query: 1478 AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVI 1537
            AY N G I +    F +A D ++ A++  P  E    NR +    L  +++A EDF  V+
Sbjct: 60   AYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVL 119

Query: 1538 ESCP 1541
            +  P
Sbjct: 120  DLNP 123



 Score = 36.6 bits (83), Expect = 0.20
 Identities = 26/82 (31%), Positives = 35/82 (42%), Gaps = 1/82 (1%)

Query: 1495 ASDYFSKALKFDPEN-EYVLMNRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHF 1553
            AS   S   K  PE+      NR         + EA +D+ + IE  P +   Y+NR   
Sbjct: 42   ASSDESPGSKCSPEDLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLI 101

Query: 1554 YYCLKQYELAEEDLNKALSLKP 1575
             Y L  ++ A ED  K L L P
Sbjct: 102  LYRLGYFDDALEDFKKVLDLNP 123



 Score = 34.7 bits (78), Expect = 0.77
 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 3/62 (4%)

Query: 1319 EFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKAR 1378
            +F EA++ +T A+++ P F   Y  RG      G+ +    A +DF K L +NP +  A 
Sbjct: 73   DFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFD---DALEDFKKVLDLNPGFQDAT 129

Query: 1379 IS 1380
            +S
Sbjct: 130  LS 131



 Score = 32.0 bits (71), Expect = 5.0
 Identities = 24/84 (28%), Positives = 37/84 (44%)

Query: 917  AFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDDLNY 976
            A AY  RG I         AM+D    I ++P F   Y++R LI       ++AL+D   
Sbjct: 58   ATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKK 117

Query: 977  IHKYNKNNTEAYLSKAEIYRGKKD 1000
            +   N    +A LS  +    K++
Sbjct: 118  VLDLNPGFQDATLSLKQTILDKEE 141


>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
            sapiens]
          Length = 833

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 37/163 (22%), Positives = 69/163 (42%), Gaps = 1/163 (0%)

Query: 914  KYPAFAYCRRGAIYRKLGKLQSAMNDLQRVILLEPLFLNAYWHRHLIYLFQDKINEALDD 973
            +Y   A   +G      G  + A    +  +  +     A ++  L Y   ++++EALD 
Sbjct: 490  RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC 549

Query: 974  LNYIHKYNKNNTEAYLSKAEIYRGKKDITLAILNYTQAIKSTPTDADIYFRRGEMYEIT- 1032
               +H   +N+ E     A IY   ++ + AI    Q +   PTD  +  + GE+Y+   
Sbjct: 550  FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG 609

Query: 1033 NKVLAIDDFSKCIFYDPKRTDALLKRGLFYCENENWFAAIEDF 1075
            +K  A   + +   Y P   + +   G +Y + + W  AI+ F
Sbjct: 610  DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYF 652



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 61/297 (20%), Positives = 110/297 (37%), Gaps = 22/297 (7%)

Query: 1135 DKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKAL--------DAISHSDK 1186
            +KA+  L    +N+A      +L  ++ K  R K A      AL         A S++D 
Sbjct: 429  NKAVTYLRQKDYNQA----VEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADI 484

Query: 1187 GPDATAISADCLYNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKI 1246
              ++   +   L N G      G+    Y+ A      A+  D +   A YN  L Y K+
Sbjct: 485  AVNSDRYNPAALTNKGNTVFANGD----YEKAAEFYKEALRNDSSCTEALYNIGLTYEKL 540

Query: 1247 RELQMALTDYGIVLLLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSL 1306
              L  AL  +   L L A              IY  +     A+E   Q   +  T+  +
Sbjct: 541  NRLDEALDCF---LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQV 597

Query: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
                   + R  +  +A  ++  + +  PC ++     G  Y++    +  ++A + F +
Sbjct: 598  LSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYID---TQFWEKAIQYFER 654

Query: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMG 1423
            A  I P  +K ++      +  G +QKA + +       P+N         +C  +G
Sbjct: 655  ASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLG 711



 Score = 40.0 bits (92), Expect = 0.018
 Identities = 87/436 (19%), Positives = 159/436 (36%), Gaps = 80/436 (18%)

Query: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMALTDYGI 1258
            Y++   Y E  N   TY++ + +      M  N+     N    Y K R    A+  Y +
Sbjct: 216  YSVNEMYAEALN---TYQVIVKN-----KMFSNAGILKMNMGNIYLKQRNYSKAIKFYRM 267

Query: 1259 VL--LLDATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHR 1316
             L  +    + +++    N G+ +++ GQY  A+  ++    ++  N    +   +C+  
Sbjct: 268  ALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMA-PNLKAGYNLTICYFA 326

Query: 1317 INEFEEAVNFF----TWALKINPCFLDAYVGRG-------------NSYMEYGHDEATKQ 1359
            I + E+    F    T  L+I+    D Y+                N ++     E    
Sbjct: 327  IGDREKMKKAFQKLITVPLEIDE---DKYISPSDDPHTNLVTEAIKNDHLRQMERERKAM 383

Query: 1360 AQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVC 1419
            A+K  + +  +    I+   + GY+   +    KA  +  +A D +    + Y       
Sbjct: 384  AEKYIMTSAKLIAPVIETSFAAGYDWCVE--VVKASQYVELANDLEINKAVTY------- 434

Query: 1420 LQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSLAY 1479
                      +D N A++I    E              K + +K            S A 
Sbjct: 435  -------LRQKDYNQAVEILKVLE-------------KKDSRVK------------SAAA 462

Query: 1480 FNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVIES 1539
             N   +Y+  + F+QAS Y   A+  D  N   L N+  T      YE+A E +   + +
Sbjct: 463  TNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRN 522

Query: 1540 CPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVYNFRAKVRGKIGLIEEAMA 1599
                    +N    Y  L + + A +   K  ++  N        A+V  +I  I E M 
Sbjct: 523  DSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNS-------AEVLYQIANIYELME 575

Query: 1600 DYNQALD-LEDYASVI 1614
            + +QA++ L    SVI
Sbjct: 576  NPSQAIEWLMQVVSVI 591



 Score = 36.2 bits (82), Expect = 0.26
 Identities = 64/353 (18%), Positives = 132/353 (37%), Gaps = 54/353 (15%)

Query: 1199 YNLGLCYMEEGNLQMTYKLAITDLTTAISMDKNSY--------TAFYNRALCYTKIRELQ 1250
            YNL +CY   G+ +   K     +T  + +D++ Y        T     A+    +R+++
Sbjct: 318  YNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQME 377

Query: 1251 ---------MALTDYGIVLLLDAT----------ETVKLNTF--------LNRGLIYVEL 1283
                       +T   ++  +  T          E VK + +        +N+ + Y+  
Sbjct: 378  RERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQ 437

Query: 1284 GQYGFALEDFK-QAALISRTNGSLCHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYV 1342
              Y  A+E  K      SR   +     +  ++   +F +A ++   A+  +     A  
Sbjct: 438  KDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALT 497

Query: 1343 GRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAI 1402
             +GN+    G  E   +A + + +AL  + +  +A  + G   +   +  +       A+
Sbjct: 498  NKGNTVFANGDYE---KAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDE-------AL 547

Query: 1403 DTDPKNYLAYEGRAVVCLQMGNNFAAMQDINAAMK--------ISTTAEFLTNRGVIHEF 1454
            D   K +      A V  Q+ N +  M++ + A++        I T  + L+  G +++ 
Sbjct: 548  DCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDR 607

Query: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDP 1507
             G K  A + Y ++    P         G  Y   + + +A  YF +A    P
Sbjct: 608  EGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQP 660


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,746,204
Number of Sequences: 37866
Number of extensions: 2775762
Number of successful extensions: 11990
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 75
Number of HSP's successfully gapped in prelim test: 151
Number of HSP's that attempted gapping in prelim test: 10740
Number of HSP's gapped (non-prelim): 1057
length of query: 1614
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1498
effective length of database: 13,855,062
effective search space: 20754882876
effective search space used: 20754882876
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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