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Search of human proteins with 239743562
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo
sapiens]
(1029 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo ... 2101 0.0
gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo ... 2099 0.0
gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens] 2095 0.0
gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sap... 127 5e-29
gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo sap... 108 3e-23
gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo sap... 96 2e-19
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 63 2e-09
gi|19923084 polycystin-1L1 [Homo sapiens] 62 4e-09
gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 58 4e-08
gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo... 58 4e-08
gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens] 58 4e-08
gi|31559825 polycystin 1-like 3 [Homo sapiens] 58 4e-08
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 58 5e-08
gi|5174633 receptor for egg jelly-like protein precursor [Homo s... 57 9e-08
gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens] 55 3e-07
gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens] 55 4e-07
gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens] 55 4e-07
gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens] 48 4e-05
gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens] 47 9e-05
gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens] 40 0.015
gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens] 37 0.096
gi|8923374 dihydrouridine synthase 2-like, SMM1 homolog [Homo sa... 35 0.48
gi|153285461 fibroblast growth factor 2 [Homo sapiens] 34 0.62
gi|4503701 fibroblast growth factor 4 precursor [Homo sapiens] 34 0.62
gi|223941891 protein tyrosine phosphatase, non-receptor type 3 i... 33 1.8
gi|223941888 protein tyrosine phosphatase, non-receptor type 3 i... 33 1.8
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 33 1.8
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 33 1.8
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 33 1.8
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 33 1.8
>gi|239743562 PREDICTED: hypothetical protein XP_002342894 [Homo
sapiens]
Length = 1029
Score = 2101 bits (5444), Expect = 0.0
Identities = 1029/1029 (100%), Positives = 1029/1029 (100%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW 120
VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW 120
Query: 121 FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF 180
FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF
Sbjct: 121 FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF 180
Query: 181 YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP 240
YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP
Sbjct: 181 YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP 240
Query: 241 DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV 300
DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV
Sbjct: 241 DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV 300
Query: 301 LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA 360
LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA
Sbjct: 301 LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA 360
Query: 361 TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG 420
TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG
Sbjct: 361 TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG 420
Query: 421 TGDVDCHFKIKKNLKNASISLESTKSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG 480
TGDVDCHFKIKKNLKNASISLESTKSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG
Sbjct: 421 TGDVDCHFKIKKNLKNASISLESTKSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG 480
Query: 481 RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW 540
RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW
Sbjct: 481 RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW 540
Query: 541 KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI 600
KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI
Sbjct: 541 KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI 600
Query: 601 LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG 660
LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG
Sbjct: 601 LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG 660
Query: 661 ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV 720
ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV
Sbjct: 661 ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV 720
Query: 721 REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL 780
REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL
Sbjct: 721 REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL 780
Query: 781 LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGCTQELEWTVLAGELDG 840
LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGCTQELEWTVLAGELDG
Sbjct: 781 LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGCTQELEWTVLAGELDG 840
Query: 841 DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM 900
DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM
Sbjct: 841 DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM 900
Query: 901 ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC 960
ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC
Sbjct: 901 ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC 960
Query: 961 KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK 1020
KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK
Sbjct: 961 KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK 1020
Query: 1021 TQSRIKSHI 1029
TQSRIKSHI
Sbjct: 1021 TQSRIKSHI 1029
>gi|239749428 PREDICTED: hypothetical protein XP_002347033 [Homo
sapiens]
Length = 1029
Score = 2099 bits (5438), Expect = 0.0
Identities = 1028/1029 (99%), Positives = 1028/1029 (99%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW 120
VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW 120
Query: 121 FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF 180
FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF
Sbjct: 121 FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF 180
Query: 181 YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP 240
YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP
Sbjct: 181 YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP 240
Query: 241 DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV 300
DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV
Sbjct: 241 DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV 300
Query: 301 LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA 360
LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA
Sbjct: 301 LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA 360
Query: 361 TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG 420
TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG
Sbjct: 361 TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG 420
Query: 421 TGDVDCHFKIKKNLKNASISLESTKSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG 480
TGDVDCHFKIKKNLKNASISLES KSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG
Sbjct: 421 TGDVDCHFKIKKNLKNASISLESMKSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG 480
Query: 481 RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW 540
RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW
Sbjct: 481 RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW 540
Query: 541 KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI 600
KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI
Sbjct: 541 KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI 600
Query: 601 LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG 660
LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG
Sbjct: 601 LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG 660
Query: 661 ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV 720
ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV
Sbjct: 661 ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV 720
Query: 721 REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL 780
REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL
Sbjct: 721 REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL 780
Query: 781 LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGCTQELEWTVLAGELDG 840
LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGCTQELEWTVLAGELDG
Sbjct: 781 LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGCTQELEWTVLAGELDG 840
Query: 841 DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM 900
DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM
Sbjct: 841 DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM 900
Query: 901 ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC 960
ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC
Sbjct: 901 ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC 960
Query: 961 KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK 1020
KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK
Sbjct: 961 KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK 1020
Query: 1021 TQSRIKSHI 1029
TQSRIKSHI
Sbjct: 1021 TQSRIKSHI 1029
>gi|239754889 PREDICTED: similar to hCG2036697 [Homo sapiens]
Length = 1029
Score = 2095 bits (5427), Expect = 0.0
Identities = 1027/1029 (99%), Positives = 1027/1029 (99%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN
Sbjct: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
Query: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW 120
VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW
Sbjct: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGW 120
Query: 121 FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF 180
FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF
Sbjct: 121 FLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLF 180
Query: 181 YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP 240
YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP
Sbjct: 181 YDDWRKHDTSEINCPLFIFSGQKLELKRKETWTAESWKFTKGNTLQFYNKLTGGFVRLHP 240
Query: 241 DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV 300
DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV
Sbjct: 241 DGTVDAIGEKTDKYGVFDVIFNKRNICIFQSHEMRHLSLALDNGIVTGMVSGEATTELRV 300
Query: 301 LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA 360
LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA
Sbjct: 301 LYQPNRCALLESALVPGHTVVFDRHGKIADASSAGYANLSKEFVIFVKGVFLNSAVVLLA 360
Query: 361 TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG 420
TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG
Sbjct: 361 TSLCQALCLQPDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTG 420
Query: 421 TGDVDCHFKIKKNLKNASISLESTKSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG 480
TGDVDCHFKIKKNLKNASISLES KSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG
Sbjct: 421 TGDVDCHFKIKKNLKNASISLESMKSPGLFVGLQSDGQAKPMIYTKDENVCFYPQVIQFG 480
Query: 481 RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW 540
RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW
Sbjct: 481 RENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKEIRHFQSSETLLSEDEW 540
Query: 541 KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI 600
KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI
Sbjct: 541 KVLVLTGNTGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQHMKSKKI 600
Query: 601 LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG 660
LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG
Sbjct: 601 LDFAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFG 660
Query: 661 ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV 720
ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV
Sbjct: 661 ERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIV 720
Query: 721 REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL 780
REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL
Sbjct: 721 REPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWGTAGSFL 780
Query: 781 LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGCTQELEWTVLAGELDG 840
LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHG TQELEWTVLAGELDG
Sbjct: 781 LQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLKRKESHGFTQELEWTVLAGELDG 840
Query: 841 DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM 900
DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM
Sbjct: 841 DWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIM 900
Query: 901 ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC 960
ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC
Sbjct: 901 ARNETCNVCTVSVENPCSNTVPACCLMLFLEKREGSVQHATEDSQLQITTVDDRKGHKRC 960
Query: 961 KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK 1020
KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK
Sbjct: 961 KCEALGDSAYKEEHTQEIDILRRVKEDMASRNPQEDPGGENILRRSSKMRDEAGDGLETK 1020
Query: 1021 TQSRIKSHI 1029
TQSRIKSHI
Sbjct: 1021 TQSRIKSHI 1029
>gi|239050813 lipoxygenase homology domains 1 isoform 1 [Homo sapiens]
Length = 2211
Score = 127 bits (319), Expect = 5e-29
Identities = 75/160 (46%), Positives = 92/160 (57%), Gaps = 3/160 (1%)
Query: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
+Q RWLAR +ED E+ E L+ G+P YEV V TG + AGT ANVY++
Sbjct: 988 EQHKFEAHRWLARGKEDNELVVE--LVPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLT 1045
Query: 65 IHGEK-GDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
I+GE+ GDTG R L +S S F +GQTDTF + A+ LG L KI I HD G GWFLD
Sbjct: 1046 IYGEEYGDTGERPLKKSDKSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLD 1105
Query: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS 163
+ I D Y F C RWL EDD ++ REL D S
Sbjct: 1106 RIDITDMNNEITYYFPCQRWLAVEEDDGQLSRELLPVDES 1145
Score = 115 bits (287), Expect = 3e-25
Identities = 67/169 (39%), Positives = 104/169 (61%), Gaps = 13/169 (7%)
Query: 13 RWLARDQEDGEICREFPLLSKGQPV---LPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
RWL +++D EI RE + ++G V + + Y V V TGEL AGT ANVY+ + G+
Sbjct: 524 RWLDANEDDNEIVRE--MTAEGPTVRRIMGMARYHVTVCTGELEGAGTDANVYLCLFGDV 581
Query: 70 GDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIK 128
GDTG R L+ +++ + F +G D F +E+V + ++ ++ I HDG G G+GW+LD V+++
Sbjct: 582 GDTGERLLYNCRNNTDLFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVR 641
Query: 129 D----PTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNS-IFSASRYHV 172
+ + N E F C RWLD+ +DD ++VREL D+S RYH+
Sbjct: 642 EEGQPESDNVE--FPCLRWLDKDKDDGQLVRELLPSDSSATLKNFRYHI 688
Score = 110 bits (275), Expect = 7e-24
Identities = 70/174 (40%), Positives = 98/174 (56%), Gaps = 7/174 (4%)
Query: 6 QFYVPVQRWLARDQEDGEICREFPLLSKGQPV-LPV-TIYEVNVATGELWNAGTVANVYI 63
++Y WL++ + D + CR+ LL+ P+ +P YEV V TG++ AGT A+V+I
Sbjct: 137 RYYFNCNNWLSKVEGDRQWCRD--LLASFNPMDMPRGNKYEVKVYTGDVIGAGTDADVFI 194
Query: 64 SIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLD 123
+I GE GDTG R+L K NF +G D F L+A LG L KI +GH+ G GWFL
Sbjct: 195 NIFGEYGDTGERRLENEKD--NFEKGAEDRFILDAPDLGQLMKINVGHNNKGGSAGWFLS 252
Query: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPG 177
+VI+D +Y F +RWL EDD KI R++ + +A Y V F G
Sbjct: 253 QIVIEDIGNKRKYDFPLNRWLALDEDDGKIQRDILV-GGAETTAITYIVTVFTG 305
Score = 108 bits (269), Expect = 3e-23
Identities = 72/203 (35%), Positives = 111/203 (54%), Gaps = 16/203 (7%)
Query: 5 KQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYIS 64
+++ P+ RWLA D++DG+I R+ +L G +T Y V V TG++ AGT + +Y+
Sbjct: 263 RKYDFPLNRWLALDEDDGKIQRD--ILVGGAETTAIT-YIVTVFTGDVRGAGTKSKIYLV 319
Query: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLE-AVHLGDLCKIVIGHDGLGPGNGWFLD 123
++G +G+ S ++F F+ RG+TD F +E AV L L ++ +GH +G GWF +
Sbjct: 320 MYGARGNKNSGKIFLEGGVFD--RGRTDIFHIELAVLLSPLSRVSVGHGNVGVNRGWFCE 377
Query: 124 DVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSIFSASRYHVYTFPGKLFY-- 181
VVI P T + F C WLD+ + D I R+LY + S + + FP L+
Sbjct: 378 KVVILCPFTGIQQTFPCSNWLDEKKADGLIERQLY----EMVSLRKKRLKKFPWSLWVWT 433
Query: 182 DDWRKHDTSEINCPLFI-FSGQK 203
D +K T N P+FI GQK
Sbjct: 434 TDLKKAGT---NSPIFIQIYGQK 453
Score = 108 bits (269), Expect = 3e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1112 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 1170
Query: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 1171 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 1230
Query: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 1231 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 1290
Query: 156 ELY 158
+L+
Sbjct: 1291 DLF 1293
Score = 105 bits (263), Expect = 2e-22
Identities = 56/151 (37%), Positives = 88/151 (58%), Gaps = 3/151 (1%)
Query: 10 PVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEK 69
P RWL +D++DG++ RE L S L Y +++ TG++ A T + VYI ++G+K
Sbjct: 654 PCLRWLDKDKDDGQLVREL-LPSDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDK 712
Query: 70 GDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVI 127
DT + L S ++ F RG+ D F LE +++G++ ++VIGHD G WFL V I
Sbjct: 713 SDTIKQVLLVSDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQI 772
Query: 128 KDPTTNYEYAFFCHRWLDQGEDDCKIVRELY 158
+ P +Y F +RWLD+ + D ++ ELY
Sbjct: 773 RVPRQGKQYTFPANRWLDKNQADGRLEVELY 803
Score = 99.0 bits (245), Expect = 2e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 1412 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 1471
Query: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 1472 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 1531
Query: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 1532 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
Score = 95.9 bits (237), Expect = 2e-19
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 2084 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 2141
Query: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 2142 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 2201
Query: 152 KIVRELY 158
R+L+
Sbjct: 2202 LTWRDLF 2208
Score = 92.8 bits (229), Expect = 1e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 1783 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 1842
Query: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 1843 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 1902
Query: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 1903 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 1947
Score = 90.5 bits (223), Expect = 7e-18
Identities = 64/227 (28%), Positives = 111/227 (48%), Gaps = 41/227 (18%)
Query: 535 LSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQV- 590
L + W + V T + GT + + + +YG KG T I L ++ + F PG ++F++
Sbjct: 422 LKKFPWSLWVWTTDLKKAGTNSPIFIQIYGQKGRTDEILLNPNN--KWFKPGIIEKFRIE 479
Query: 591 ----------------------------TMQHMKSKKILDFAANVWLSRIQADGDVVCEL 622
T+ + +K +F N WL + D ++V E+
Sbjct: 480 LPDLGRFYKIRVWHDKRSSGSGWHLERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREM 539
Query: 623 ----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYK-SNMQV 677
P V+ + + RY V V TG+L+ A T++ V+LCLFG+ GD+G R LY N
Sbjct: 540 TAEGPTVR--RIMGMARYHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTD 597
Query: 678 KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
F++G D+F + +V++ +++V +R + WY ++V+VRE G
Sbjct: 598 LFEKGNADEFTIESVTMRNVRRVRIRHDGKGSGSGWYLDRVLVREEG 644
Score = 90.1 bits (222), Expect = 1e-17
Identities = 53/126 (42%), Positives = 74/126 (58%), Gaps = 5/126 (3%)
Query: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
GKQ+ P RWL ++Q DG + E +P S+ + + YEV + TG++ AGT A VY
Sbjct: 778 GKQYTFPANRWLDKNQADGRLEVELYP--SEVVEIQKLVHYEVEIWTGDVGGAGTSARVY 835
Query: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
+ I+GEKG T LF S S F R DTF LEA +G++ K+ +GH G G G WF+
Sbjct: 836 MQIYGEKGKT--EVLFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFV 893
Query: 123 DDVVIK 128
D V ++
Sbjct: 894 DTVWLR 899
Score = 88.6 bits (218), Expect = 3e-17
Identities = 59/181 (32%), Positives = 93/181 (51%), Gaps = 6/181 (3%)
Query: 3 SGKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANV 61
+G Q P WL + DG I R+ + ++S + L + + V T +L AGT + +
Sbjct: 386 TGIQQTFPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFPWSLWVWTTDLKKAGTNSPI 445
Query: 62 YISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWF 121
+I I+G+KG T ++ + ++ F G + F +E LG KI + HD G+GW
Sbjct: 446 FIQIYGQKGRTD--EILLNPNNKWFKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWH 503
Query: 122 LDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD---NSIFSASRYHVYTFPGK 178
L+ + + + +Y F C+RWLD EDD +IVRE+ A I +RYHV G+
Sbjct: 504 LERMTLMNTLNKDKYNFNCNRWLDANEDDNEIVREMTAEGPTVRRIMGMARYHVTVCTGE 563
Query: 179 L 179
L
Sbjct: 564 L 564
Score = 84.0 bits (206), Expect = 7e-16
Identities = 68/214 (31%), Positives = 110/214 (51%), Gaps = 20/214 (9%)
Query: 562 DKGVTGPISLRKDSS---EQLFLPGHEDEFQVTMQHMKSKKILDFAANVWLSRIQADGDV 618
D+G S ++SS E++ E+EF MQ + + F A+ WL+R + D ++
Sbjct: 950 DEGEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQH--KFEAHRWLARGKEDNEL 1007
Query: 619 VCEL-PVVKGGQAIFPLR--YQVDVYTGQLKHAETESEVFLCLFGER-GDSGLRQLYKSN 674
V EL P K G P R Y+V V TG + A T++ V+L ++GE GD+G R L KS+
Sbjct: 1008 VVELVPAGKPG----PERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSD 1063
Query: 675 MQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQ 734
KF++GQ D F + A+ LG L K+ +R + + W+ +++ + + F CQ
Sbjct: 1064 KSNKFEQGQTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQ 1123
Query: 735 ---SLPAHNFQASPSMLYRDETVPTSLILKGAEE 765
++ + Q S +L DE S +L +EE
Sbjct: 1124 RWLAVEEDDGQLSRELLPVDE----SYVLPQSEE 1153
Score = 83.2 bits (204), Expect = 1e-15
Identities = 54/165 (32%), Positives = 84/165 (50%), Gaps = 13/165 (7%)
Query: 16 ARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR 75
A + ++GE+ E+ +YEV ATG++ AGT ANV+I++ GE G +
Sbjct: 27 ASEDDEGELEHEY---------YKARVYEVVTATGDVRGAGTDANVFITLFGENGLSPKL 77
Query: 76 QLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKD-PTTNY 134
QL SKS F +G D F + ++G + K+ I HD G W+LD V++ D +
Sbjct: 78 QL-TSKSKSAFEKGNVDVFRVRTNNVGLIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHL 136
Query: 135 EYAFFCHRWLDQGEDDCKIVRELYARDN--SIFSASRYHVYTFPG 177
Y F C+ WL + E D + R+L A N + ++Y V + G
Sbjct: 137 RYYFNCNNWLSKVEGDRQWCRDLLASFNPMDMPRGNKYEVKVYTG 181
Score = 79.3 bits (194), Expect = 2e-14
Identities = 58/221 (26%), Positives = 106/221 (47%), Gaps = 37/221 (16%)
Query: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRK-DSSEQLFLPGHEDEF---QVTM 592
+ V V TG GT ANV L ++GD G TG L ++ LF G+ DEF VTM
Sbjct: 555 YHVTVCTGELEGAGTDANVYLCLFGDVGDTGERLLYNCRNNTDLFEKGNADEFTIESVTM 614
Query: 593 QHMKSKKI----------------------------LDFAANVWLSRIQADGDVVCELPV 624
++++ +I ++F WL + + DG +V EL
Sbjct: 615 RNVRRVRIRHDGKGSGSGWYLDRVLVREEGQPESDNVEFPCLRWLDKDKDDGQLVRELLP 674
Query: 625 VKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRG 682
+ RY + + TG + A T+S V++ L+G++ D+ + L S+ +K F+RG
Sbjct: 675 SDSSATLKNFRYHISLKTGDVSGASTDSRVYIKLYGDKSDTIKQVLLVSDNNLKDYFERG 734
Query: 683 QIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREP 723
++D+F + +++G + ++++ +++ W+ V +R P
Sbjct: 735 RVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVP 775
Score = 79.0 bits (193), Expect = 2e-14
Identities = 59/231 (25%), Positives = 110/231 (47%), Gaps = 39/231 (16%)
Query: 538 DEWKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF------ 588
++++V V TG+ GT A+V + ++G+ G TG R ++ + F G ED F
Sbjct: 172 NKYEVKVYTGDVIGAGTDADVFINIFGEYGDTG--ERRLENEKDNFEKGAEDRFILDAPD 229
Query: 589 -----------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVV 625
Q+ ++ + +K+ DF N WL+ + DG + + ++
Sbjct: 230 LGQLMKINVGHNNKGGSAGWFLSQIVIEDIGNKRKYDFPLNRWLALDEDDGKI--QRDIL 287
Query: 626 KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQID 685
GG + Y V V+TG ++ A T+S+++L ++G RG+ +++ F RG+ D
Sbjct: 288 VGGAETTAITYIVTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEG--GVFDRGRTD 345
Query: 686 KFQV-AAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQS 735
F + AV L L +V + ++ W+CE+V++ P T + F C +
Sbjct: 346 IFHIELAVLLSPLSRVSVGHGNVGVNRGWFCEKVVILCPFTGIQQTFPCSN 396
Score = 77.4 bits (189), Expect = 6e-14
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 1268 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 1327
Query: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 1328 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 1387
Query: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
GW V I+ D F C RWL EDD K +REL D
Sbjct: 1388 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 1434
Score = 75.1 bits (183), Expect = 3e-13
Identities = 89/394 (22%), Positives = 160/394 (40%), Gaps = 54/394 (13%)
Query: 514 RSPLPSSTAKEIRHFQSSETLLSEDEWKVLVLTGNTGTQANVTLWVYGDKGVT-GPISLR 572
R LPS ++ +++F+ +L + D T + V + +YGDK T + L
Sbjct: 670 RELLPSDSSATLKNFRYHISLKTGD-------VSGASTDSRVYIKLYGDKSDTIKQVLLV 722
Query: 573 KDSS-EQLFLPGHEDEF-----------------------------QVTMQHMKSKKILD 602
D++ + F G DEF V ++ + K
Sbjct: 723 SDNNLKDYFERGRVDEFTLETLNIGNINRLVIGHDSTGMHASWFLGSVQIRVPRQGKQYT 782
Query: 603 FAANVWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGER 662
F AN WL + QADG + EL + + + Y+V+++TG + A T + V++ ++GE+
Sbjct: 783 FPANRWLDKNQADGRLEVELYPSEVVEIQKLVHYEVEIWTGDVGGAGTSARVYMQIYGEK 842
Query: 663 GDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV---- 718
G + + L+ S+ F+R D FQ+ A +G++ K+ L W+ + V
Sbjct: 843 GKTEV--LFLSSRSKVFERASKDTFQLEAADVGEVYKLRLGHTGEGFGPSWFVDTVWLRH 900
Query: 719 -IVREPGTTSESIFTCQSLPAHNFQASPSMLYRDETVPTSLILKGAEEYGTRNRTWG--T 775
+VRE T E + + L + E + L K + G+ G
Sbjct: 901 LVVREVDLTPE-----EEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGEEE 955
Query: 776 AGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVH--GAWKAVLKRKESHGCTQELEWTV 833
S + + + + + + + H A + + + KE + EL
Sbjct: 956 ESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVELVPAG 1015
Query: 834 LAGELDGDWKVTIVTGDLENAGTTATVFLYVYGE 867
G ++V +VTG++ AGT A V+L +YGE
Sbjct: 1016 KPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGE 1049
Score = 74.3 bits (181), Expect = 5e-13
Identities = 59/220 (26%), Positives = 104/220 (47%), Gaps = 39/220 (17%)
Query: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEFQVTMQH-- 594
++V+ TG+ GT ANV + ++G+ G++ + L S+ F G+ D F+V +
Sbjct: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTS-KSKSAFEKGNVDVFRVRTNNVG 103
Query: 595 -------------MKSKKILD---------------FAANVWLSRIQADGDVVCELPVVK 626
+ + LD F N WLS+++ D +L +
Sbjct: 104 LIYKVRIEHDNTGLNASWYLDHVIVTDMKRPHLRYYFNCNNWLSKVEGDRQWCRDL-LAS 162
Query: 627 GGQAIFPL--RYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQI 684
P +Y+V VYTG + A T+++VF+ +FGE GD+G R+L N + F++G
Sbjct: 163 FNPMDMPRGNKYEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL--ENEKDNFEKGAE 220
Query: 685 DKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
D+F + A LG+L K+ + S W+ Q+++ + G
Sbjct: 221 DRFILDAPDLGQLMKINVGHNNKGGSAGWFLSQIVIEDIG 260
Score = 74.3 bits (181), Expect = 5e-13
Identities = 83/331 (25%), Positives = 129/331 (38%), Gaps = 70/331 (21%)
Query: 480 GRENPMGMSATPSQEEEKIHESKKQKKIPPESEARSPLPSSTAKE--IRHFQSSETLLS- 536
G E S S EEE++ E +++++ P + A R + +E ++
Sbjct: 952 GEEEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWLARGKEDNELVVEL 1011
Query: 537 ---------EDEWKVLVLTGNT---GTQANVTLWVYGDK-GVTGPISLRKDSSEQLFLPG 583
+ ++V V+TGN GT ANV L +YG++ G TG L+K F G
Sbjct: 1012 VPAGKPGPERNTYEVQVVTGNVPKAGTDANVYLTIYGEEYGDTGERPLKKSDKSNKFEQG 1071
Query: 584 HEDEF-----------------------------QVTMQHMKSKKILDFAANVWLSRIQA 614
D F ++ + M ++ F WL+ +
Sbjct: 1072 QTDTFTIYAIDLGALTKIRIRHDNTGNRAGWFLDRIDITDMNNEITYYFPCQRWLAVEED 1131
Query: 615 DGDVVCELPVV------------KGGQAIFPL------------RYQVDVYTGQLKHAET 650
DG + EL V +GG PL + V + TG K+A T
Sbjct: 1132 DGQLSRELLPVDESYVLPQSEEGRGGGDNNPLDNLALEQKDKSTTFSVTIKTGVKKNAGT 1191
Query: 651 ESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSLGKLQKVLLRCEASDK 709
++ VF+ LFG + D+G+ L S KF+R I+ F V + LG L KV L + + K
Sbjct: 1192 DANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGK 1251
Query: 710 SQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
+ W+ + V V P F C A N
Sbjct: 1252 APGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 1282
Score = 73.9 bits (180), Expect = 7e-13
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 2087 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 2145
Query: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 2146 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 2190
Score = 71.6 bits (174), Expect = 4e-12
Identities = 39/118 (33%), Positives = 65/118 (55%), Gaps = 2/118 (1%)
Query: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHL 101
+YE+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 1697 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDI 1754
Query: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 1755 APFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 1812
Score = 68.9 bits (167), Expect = 2e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
Query: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
G + K+ LR + S WY E+V + E +F C
Sbjct: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 1560
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 1698 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 1755
Query: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 1756 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 1815
Query: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 1816 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 1875
Query: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
F +SLG L K+ + + W+ V V++ F C
Sbjct: 1876 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 1923
Score = 57.4 bits (137), Expect = 7e-08
Identities = 98/443 (22%), Positives = 163/443 (36%), Gaps = 118/443 (26%)
Query: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 1462 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 1521
Query: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
++ ++H SK D F WLS + DG +
Sbjct: 1522 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 1581
Query: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
C P V G A + + Y V V TG+ K A
Sbjct: 1582 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 1641
Query: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ E
Sbjct: 1642 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKI----EV 1696
Query: 707 SDKSQYWYCEQVIVREPGTTSESIF--------TCQSLPAHNFQASPSMLYRDETVPTSL 758
+ W + V G T +IF + + + +A D + L
Sbjct: 1697 LYEMTVWTGDVV----GGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEIL 1752
Query: 759 ILKGAEEYGTRNRTWGTAGSFLLQKKAILKPLIVTSVSQSLFCAYEVKVSVHGAWKAVLK 818
+ + R G+ + L++ +++ +++ ++ + +G W + K
Sbjct: 1753 DIAPFTKMRIRIDGLGSRPEWFLER------ILLKNMNTG-----DLTMFYYGDWLSQRK 1801
Query: 819 RKESHGC--------TQELEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKC 870
K++ C + +EWT + V + T D+ AGT A VF+ ++GE
Sbjct: 1802 GKKTLVCEMCAVIDEEEMMEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGD 1853
Query: 871 SGPIIL-GSGKHQLFNPNTADIF 892
SG + L S F N D F
Sbjct: 1854 SGTLALKQSANWNKFERNNTDTF 1876
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 1919 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 1975
Query: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 1976 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 2035
Query: 119 GWFLDDVVIKDPTTNYEYAFFC 140
W + + I + Y F C
Sbjct: 2036 AWHVKTITITEMEYGNVYFFNC 2057
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 1817 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 1876
Query: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
+++ H+ ++ F + WLS+ + DG
Sbjct: 1877 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 1936
Query: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 1937 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 1994
Query: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 1995 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 2054
Query: 731 FTCQSL 736
F C L
Sbjct: 2055 FNCDCL 2060
Score = 44.3 bits (103), Expect = 6e-04
Identities = 34/135 (25%), Positives = 63/135 (46%), Gaps = 8/135 (5%)
Query: 603 FAANVWLSRIQADGDVVCEL----PVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCL 658
F + WL +ADG + +L + K FP + + V+T LK A T S +F+ +
Sbjct: 392 FPCSNWLDEKKADGLIERQLYEMVSLRKKRLKKFP--WSLWVWTTDLKKAGTNSPIFIQI 449
Query: 659 FGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWYCEQV 718
+G++G + L +N F+ G I+KF++ LG+ K+ + + W+ E++
Sbjct: 450 YGQKGRTDEILLNPNNKW--FKPGIIEKFRIELPDLGRFYKIRVWHDKRSSGSGWHLERM 507
Query: 719 IVREPGTTSESIFTC 733
+ + F C
Sbjct: 508 TLMNTLNKDKYNFNC 522
Score = 40.8 bits (94), Expect = 0.007
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 1236
Query: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 1237 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 1296
Query: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 1297 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 1356
Query: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 1357 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 1397
Score = 38.5 bits (88), Expect = 0.033
Identities = 18/52 (34%), Positives = 27/52 (51%)
Query: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
++V TGD+ AGT A VF+ ++GE S + L S F D+F+
Sbjct: 45 YEVVTATGDVRGAGTDANVFITLFGENGLSPKLQLTSKSKSAFEKGNVDVFR 96
Score = 36.2 bits (82), Expect = 0.16
Identities = 21/51 (41%), Positives = 29/51 (56%), Gaps = 5/51 (9%)
Query: 844 VTIVTGDLENAGTTATVFLYVYGE--TKCSGPIILGSGKHQLFNPNTADIF 892
VT+ TGD+ AGT + ++L +YG K SG I L G +F+ DIF
Sbjct: 300 VTVFTGDVRGAGTKSKIYLVMYGARGNKNSGKIFLEGG---VFDRGRTDIF 347
Score = 35.4 bits (80), Expect = 0.28
Identities = 18/52 (34%), Positives = 32/52 (61%), Gaps = 1/52 (1%)
Query: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFK 893
++V I TGD+ AGT+A V++ +YGE K ++ S + ++F + D F+
Sbjct: 816 YEVEIWTGDVGGAGTSARVYMQIYGE-KGKTEVLFLSSRSKVFERASKDTFQ 866
Score = 33.5 bits (75), Expect = 1.1
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 1177 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 1229
Score = 32.7 bits (73), Expect = 1.8
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 2077 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 2135
Query: 580 FLPGHEDEF 588
F G D F
Sbjct: 2136 FERGSTDRF 2144
Score = 30.8 bits (68), Expect = 6.9
Identities = 19/54 (35%), Positives = 28/54 (51%), Gaps = 9/54 (16%)
Query: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGKHQLFNPNTADIFKKG 895
++V + TGD+ AGT A VF+ ++GE +G L N D F+KG
Sbjct: 174 YEVKVYTGDVIGAGTDADVFINIFGEYGDTGERRL---------ENEKDNFEKG 218
>gi|224458288 lipoxygenase homology domains 1 isoform 2 [Homo
sapiens]
Length = 1114
Score = 108 bits (269), Expect = 3e-23
Identities = 66/183 (36%), Positives = 94/183 (51%), Gaps = 26/183 (14%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLP--------------------- 39
MN+ +Y P QRWLA +++DG++ RE + + VLP
Sbjct: 1 MNNEITYYFPCQRWLAVEEDDGQLSRELLPVDESY-VLPQSEEGRGGGDNNPLDNLALEQ 59
Query: 40 ---VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSK-SSFNFLRGQTDTFF 95
T + V + TG NAGT ANV+I++ G + DTG L SK +S F R + F
Sbjct: 60 KDKSTTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFT 119
Query: 96 LEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
+E + LGDL K+ +GHD G GWF+D V + P+ F C RWL + EDD I+R
Sbjct: 120 VETLDLGDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIR 179
Query: 156 ELY 158
+L+
Sbjct: 180 DLF 182
Score = 99.0 bits (245), Expect = 2e-20
Identities = 57/170 (33%), Positives = 87/170 (51%), Gaps = 18/170 (10%)
Query: 10 PVQRWLARDQEDGEICREF-----------------PLLSKGQPVLPVTIYEVNVATGEL 52
P RWLA ++D + RE + + + L + +Y V + TG +
Sbjct: 301 PCDRWLATSEDDKKTIRELVPYDIFTEKYMKDGSLRQVYKEVEEPLDIVLYSVQIFTGNI 360
Query: 53 WNAGTVANVYISIHGEKGDTGSRQLFRSKSSFN-FLRGQTDTFFLEAVHLGDLCKIVIGH 111
AGT A VYI+I+G+ GDTG R L +S++ N F RG DTF +EA LG + KI + H
Sbjct: 361 PGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADLGVIYKIKLRH 420
Query: 112 DGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
D W+++ V I + T E+ F C RWL ++D ++ R Y ++
Sbjct: 421 DNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
Score = 92.8 bits (229), Expect = 1e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 734 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 793
Query: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 794 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 853
Query: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 854 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 898
Score = 84.3 bits (207), Expect = 5e-16
Identities = 51/157 (32%), Positives = 83/157 (52%), Gaps = 3/157 (1%)
Query: 4 GKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTI-YEVNVATGELWNAGTVANVY 62
G ++ + WLA+D+ DG R F LL + V + YE+ V TG++ GT +N++
Sbjct: 609 GTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLYEMTVWTGDVVGGGTDSNIF 668
Query: 63 ISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGHDGLGPGNGWFL 122
++++G G T QL + K+ F R Q DTF +E + + K+ I DGLG WFL
Sbjct: 669 MTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPFTKMRIRIDGLGSRPEWFL 726
Query: 123 DDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 727 ERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 763
Score = 77.4 bits (189), Expect = 6e-14
Identities = 56/167 (33%), Positives = 81/167 (48%), Gaps = 9/167 (5%)
Query: 4 GKQFYVPVQRWLARDQEDGEICRE-FPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVY 62
GK P RWLA++++DG I R+ F + + P YE+ + T +++ AGT AN++
Sbjct: 157 GKCMTFPCGRWLAKNEDDGSIIRDLFHAELQTRLYTPFVPYEITLYTSDVFAAGTDANIF 216
Query: 63 ISIHG-EKGDTGSRQLFRSKSSFN--FLRGQTDTFFLEAVHLGDLC-KIVIGHDGLGPGN 118
I I+G + T + L +K F R F +E +G++ KI IGH+ G
Sbjct: 217 IIIYGCDAVCTQQKYLCTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTGMNP 276
Query: 119 GWFLDDVVIK----DPTTNYEYAFFCHRWLDQGEDDCKIVRELYARD 161
GW V I+ D F C RWL EDD K +REL D
Sbjct: 277 GWHCSHVDIRRLLPDKDGAETLTFPCDRWLATSEDDKKTIRELVPYD 323
Score = 68.9 bits (167), Expect = 2e-11
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKS-NMQVKFQRGQIDKFQVAAVSL 694
Y V ++TG + A T+++V++ ++G+ GD+G R L KS N KF+RG D F + A L
Sbjct: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Query: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
G + K+ LR + S WY E+V + E +F C
Sbjct: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLC 449
Score = 63.5 bits (153), Expect = 1e-09
Identities = 33/113 (29%), Positives = 58/113 (51%), Gaps = 1/113 (0%)
Query: 39 PVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSR-QLFRSKSSFNFLRGQTDTFFLE 97
P+ Y V+V TG+ +A T + +I + GE + R L + F RG + F++
Sbjct: 514 PIIPYYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWLDYPRGKRGFSRGSVEEFYVA 573
Query: 98 AVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDD 150
+ +G + KI +GHDG P + W ++++ + PT +Y C+ WL + D
Sbjct: 574 GLDVGIIKKIELGHDGASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGD 626
Score = 62.8 bits (151), Expect = 2e-09
Identities = 107/487 (21%), Positives = 171/487 (35%), Gaps = 144/487 (29%)
Query: 540 WKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSE-QLFLPGHEDEF------- 588
+ V + TGN GT A V + +YGD G TG L K + F G D F
Sbjct: 351 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTNKFERGTADTFIIEAADL 410
Query: 589 ----QVTMQHMKSKKILD------------------FAANVWLSRIQADGDVV------- 619
++ ++H SK D F WLS + DG +
Sbjct: 411 GVIYKIKLRHDNSKWCADWYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEKE 470
Query: 620 --------CELPV------------------VKGGQAIFP-----LRYQVDVYTGQLKHA 648
C P V G A + + Y V V TG+ K A
Sbjct: 471 YTGDRSSNCSSPADFWEIALSSKMADVDISTVTGPMADYVQEGPIIPYYVSVTTGKHKDA 530
Query: 649 ETESEVFLCLFGERGDSGLRQLYKSNMQVK--FQRGQIDKFQVAAVSLGKLQKVLLRCEA 706
T+S F+ L GE D ++++ + K F RG +++F VA + +G ++K+ L +
Sbjct: 531 ATDSRAFIFLIGE-DDERSKRIWLDYPRGKRGFSRGSVEEFYVAGLDVGIIKKIELGHDG 589
Query: 707 SDKSQYWYCEQVIVREPGTTSESIFTCQS-----------------LPAHNFQASPSMLY 749
+ W E++ + P ++ + C L A +LY
Sbjct: 590 ASPESCWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGITSRVFDLLDAMVVNIGVKVLY 649
Query: 750 RDETVPTSLILKGAEEYGTRNRTWGTAGSF----LLQKKAILK-----PLIVTSVSQSLF 800
+ TV T ++ G + +G GS L +KKA + I+ + + F
Sbjct: 650 -EMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEILDIAPF 708
Query: 801 CAYEVKVS--------------------------VHGAWKAVLKRKESHGC--------T 826
+++ +G W + K K++ C
Sbjct: 709 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEE 768
Query: 827 QELEWTVLAGELDGDWKVTIVTGDLENAGTTATVFLYVYGETKCSGPIIL-GSGKHQLFN 885
+ +EWT + V + T D+ AGT A VF+ ++GE SG + L S F
Sbjct: 769 EMMEWT--------SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFE 820
Query: 886 PNTADIF 892
N D F
Sbjct: 821 RNNTDTF 827
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/70 (51%), Positives = 44/70 (62%), Gaps = 2/70 (2%)
Query: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 1035 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 1092
Query: 92 DTFFLEAVHL 101
D FFLE + L
Sbjct: 1093 DRFFLETLEL 1102
Score = 58.2 bits (139), Expect = 4e-08
Identities = 56/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 540 WKVLVLTGNT---GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF-------- 588
+++ V TG+ GT +N+ + +YG G T + L D + F D F
Sbjct: 649 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIA 706
Query: 589 ---------------------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKG 627
++ +++M + + F WLS+ + +VCE+ V
Sbjct: 707 PFTKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVID 766
Query: 628 GQAIFP-LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDK 686
+ + Y V V T + A T++ VF+ +FGE GDSG L +S KF+R D
Sbjct: 767 EEEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDT 826
Query: 687 FQVA-AVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
F +SLG L K+ + + W+ V V++ F C
Sbjct: 827 FNFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 874
Score = 56.6 bits (135), Expect = 1e-07
Identities = 36/106 (33%), Positives = 53/106 (50%), Gaps = 1/106 (0%)
Query: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQV-KFQRGQIDKFQVAAVSL 694
+ V + TG K+A T++ VF+ LFG + D+G+ L S KF+R I+ F V + L
Sbjct: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
Query: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQSLPAHN 740
G L KV L + + K+ W+ + V V P F C A N
Sbjct: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKN 171
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 870 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 926
Query: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 927 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 986
Query: 119 GWFLDDVVIKDPTTNYEYAFFC 140
W + + I + Y F C
Sbjct: 987 AWHVKTITITEMEYGNVYFFNC 1008
Score = 51.6 bits (122), Expect = 4e-06
Identities = 26/66 (39%), Positives = 42/66 (63%), Gaps = 1/66 (1%)
Query: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 1038 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 1096
Query: 689 VAAVSL 694
+ + L
Sbjct: 1097 LETLEL 1102
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 768 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 827
Query: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
+++ H+ ++ F + WLS+ + DG
Sbjct: 828 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 887
Query: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 888 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 945
Query: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 946 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 1005
Query: 731 FTCQSL 736
F C L
Sbjct: 1006 FNCDCL 1011
Score = 40.8 bits (94), Expect = 0.007
Identities = 44/221 (19%), Positives = 95/221 (42%), Gaps = 39/221 (17%)
Query: 540 WKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLR----------KDSSEQLFLP---- 582
+ V + TG N GT ANV + ++G + TG L+ +DS E +
Sbjct: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIFTVETLDL 125
Query: 583 --------GHEDEFQ--------VTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVK 626
GH++ + V + K + F WL++ + DG ++ +L +
Sbjct: 126 GDLWKVRLGHDNTGKAPGWFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHAE 185
Query: 627 GGQAIFP--LRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVK---FQR 681
++ + Y++ +YT + A T++ +F+ ++G ++ +N + + F+R
Sbjct: 186 LQTRLYTPFVPYEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKREQKQFFER 245
Query: 682 GQIDKFQVAAVSLGK-LQKVLLRCEASDKSQYWYCEQVIVR 721
+F V +G+ ++K+ + + + W+C V +R
Sbjct: 246 KSASRFIVELEDVGEIIEKIRIGHNNTGMNPGWHCSHVDIR 286
Score = 33.5 bits (75), Expect = 1.1
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 842 WKVTIVTGDLENAGTTATVFLYVYGETKCSGPIILGSGK--HQLFNPNTADIF 892
+ VTI TG +NAGT A VF+ ++G +G +L S K F ++ +IF
Sbjct: 66 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSDKFERDSIEIF 118
Score = 32.7 bits (73), Expect = 1.8
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 1028 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 1086
Query: 580 FLPGHEDEF 588
F G D F
Sbjct: 1087 FERGSTDRF 1095
>gi|224458290 lipoxygenase homology domains 1 isoform 3 [Homo
sapiens]
Length = 512
Score = 95.9 bits (237), Expect = 2e-19
Identities = 55/127 (43%), Positives = 75/127 (59%), Gaps = 2/127 (1%)
Query: 32 SKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQT 91
SK Q ++PV YEV V TG AGT ANV+++I G GDTG R+L + K F RG T
Sbjct: 385 SKVQSLVPVK-YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGST 442
Query: 92 DTFFLEAVHLGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDC 151
D FFLE + LG+L K+ + HD G +GW ++ V + + +T F C RWLD+ D
Sbjct: 443 DRFFLETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNCGRWLDKKRGDG 502
Query: 152 KIVRELY 158
R+L+
Sbjct: 503 LTWRDLF 509
Score = 92.8 bits (229), Expect = 1e-18
Identities = 57/165 (34%), Positives = 85/165 (51%), Gaps = 1/165 (0%)
Query: 1 MNSGKQFYVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVAN 60
MN+G WL++ + + E + + ++ T Y V V T ++ AGT AN
Sbjct: 84 MNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVAVKTSDILGAGTDAN 143
Query: 61 VYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTF-FLEAVHLGDLCKIVIGHDGLGPGNG 119
V+I I GE GD+G+ L +S + F R TDTF F + + LG LCK+ + HD G G
Sbjct: 144 VFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 203
Query: 120 WFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYARDNSI 164
W L V +KD + + + F C WL + E D + VR+ +N I
Sbjct: 204 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACANNKI 248
Score = 73.9 bits (180), Expect = 7e-13
Identities = 40/105 (38%), Positives = 62/105 (59%), Gaps = 1/105 (0%)
Query: 629 QAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQ 688
Q++ P++Y+V V TG A T++ VF+ +FG GD+G R+L K M+ F+RG D+F
Sbjct: 388 QSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNLFERGSTDRFF 446
Query: 689 VAAVSLGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
+ + LG+L+KV L ++S W E+V V T +IF C
Sbjct: 447 LETLELGELRKVRLEHDSSGYCSGWLVEKVEVTNTSTGVATIFNC 491
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/115 (32%), Positives = 62/115 (53%), Gaps = 2/115 (1%)
Query: 45 VNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDL 104
+ V TG++ GT +N++++++G G T QL + K+ F R Q DTF +E + +
Sbjct: 1 MTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFE--REQNDTFIMEILDIAPF 58
Query: 105 CKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVRELYA 159
K+ I DGLG WFL+ +++K+ T F+ WL Q + +V E+ A
Sbjct: 59 TKMRIRIDGLGSRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCA 113
Score = 57.0 bits (136), Expect = 9e-08
Identities = 53/215 (24%), Positives = 86/215 (40%), Gaps = 33/215 (15%)
Query: 550 GTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF--------------------- 588
GT +N+ + +YG G T + L D + F D F
Sbjct: 12 GTDSNIFMTLYGINGSTEEMQL--DKKKARFEREQNDTFIMEILDIAPFTKMRIRIDGLG 69
Query: 589 --------QVTMQHMKSKKILDFAANVWLSRIQADGDVVCELPVVKGGQAIFP-LRYQVD 639
++ +++M + + F WLS+ + +VCE+ V + + Y V
Sbjct: 70 SRPEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAVIDEEEMMEWTSYTVA 129
Query: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVA-AVSLGKLQ 698
V T + A T++ VF+ +FGE GDSG L +S KF+R D F +SLG L
Sbjct: 130 VKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFPDMLSLGHLC 189
Query: 699 KVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
K+ + + W+ V V++ F C
Sbjct: 190 KLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQC 224
Score = 55.8 bits (133), Expect = 2e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 11/142 (7%)
Query: 7 FYVPVQRWLARDQEDGEICREFPLLS-KGQPVLPVTIYEVNVATGELWNAG-TVANVYIS 64
F+ WL++ + DG+ R+F + K L T YE+ + TG N G T NV++
Sbjct: 220 FHFQCDCWLSKSEGDGQTVRDFACANNKICDELEETTYEIVIETG---NGGETRENVWLI 276
Query: 65 IHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIGH----DGLGPGN-- 118
+ G K + + S F +G TDTF ++++LGD+ + +GH D P
Sbjct: 277 LEGRKNRSKEFLMENSSRQRAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKREL 336
Query: 119 GWFLDDVVIKDPTTNYEYAFFC 140
W + + I + Y F C
Sbjct: 337 AWHVKTITITEMEYGNVYFFNC 358
Score = 49.3 bits (116), Expect = 2e-05
Identities = 49/246 (19%), Positives = 98/246 (39%), Gaps = 43/246 (17%)
Query: 532 ETLLSEDEWKVLVLTGN---TGTQANVTLWVYGDKGVTGPISLRKDSSEQLFLPGHEDEF 588
E ++ + V V T + GT ANV + ++G+ G +G ++L++ ++ F + D F
Sbjct: 118 EEMMEWTSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTF 177
Query: 589 Q----VTMQHMKSKKI--------------------------LDFAANVWLSRIQADGDV 618
+++ H+ ++ F + WLS+ + DG
Sbjct: 178 NFPDMLSLGHLCKLRVWHDNKGIFPGWHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQT 237
Query: 619 VCELPVV--KGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQ 676
V + K + Y++ + TG ET V+L L G + S + S+ Q
Sbjct: 238 VRDFACANNKICDELEETTYEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQ 295
Query: 677 VKFQRGQIDKFQVAAVSLGKLQKVLLRCEASD------KSQYWYCEQVIVREPGTTSESI 730
F++G D F+ ++ LG + + + A + + W+ + + + E +
Sbjct: 296 RAFRKGTTDTFEFDSIYLGDIASLCVGHLAREDRFIPKRELAWHVKTITITEMEYGNVYF 355
Query: 731 FTCQSL 736
F C L
Sbjct: 356 FNCDCL 361
Score = 44.7 bits (104), Expect = 5e-04
Identities = 23/92 (25%), Positives = 47/92 (51%), Gaps = 2/92 (2%)
Query: 640 VYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQK 699
V+TG + T+S +F+ L+G G + QL K + +F+R Q D F + + + K
Sbjct: 3 VWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTK 60
Query: 700 VLLRCEASDKSQYWYCEQVIVREPGTTSESIF 731
+ +R + W+ E+++++ T ++F
Sbjct: 61 MRIRIDGLGSRPEWFLERILLKNMNTGDLTMF 92
Score = 38.1 bits (87), Expect = 0.043
Identities = 27/92 (29%), Positives = 40/92 (43%), Gaps = 17/92 (18%)
Query: 810 HGAWKAVLKRKESHGCT--------QELEWTVLAGELDGDWKVTIVTGDLENAGTTATVF 861
+G W + K K++ C + +EWT + V + T D+ AGT A VF
Sbjct: 94 YGDWLSQRKGKKTLVCEMCAVIDEEEMMEWT--------SYTVAVKTSDILGAGTDANVF 145
Query: 862 LYVYGETKCSGPIIL-GSGKHQLFNPNTADIF 892
+ ++GE SG + L S F N D F
Sbjct: 146 IIIFGENGDSGTLALKQSANWNKFERNNTDTF 177
Score = 32.7 bits (73), Expect = 1.8
Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 4/69 (5%)
Query: 523 KEIRHFQSSETLLSEDEWKVLVLTG---NTGTQANVTLWVYGDKGVTGPISLRKDSSEQL 579
K F S L +++V+V TG GT ANV + ++G G TG L K L
Sbjct: 378 KTTESFASKVQSLVPVKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKREL-KQKMRNL 436
Query: 580 FLPGHEDEF 588
F G D F
Sbjct: 437 FERGSTDRF 445
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 62.8 bits (151), Expect = 2e-09
Identities = 37/107 (34%), Positives = 54/107 (50%), Gaps = 10/107 (9%)
Query: 51 ELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCKIVIG 110
+L NA +N +I + GE GDTG Q+ ++ F E +LG L + IG
Sbjct: 947 KLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTF----------ECQNLGKLTTVQIG 996
Query: 111 HDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVREL 157
HD G W +D V++++ T + Y F C RWL +G DD + R L
Sbjct: 997 HDNSGLLAKWLVDCVMVRNEITGHTYRFPCGRWLGKGIDDGSLERIL 1043
Score = 36.2 bits (82), Expect = 0.16
Identities = 25/90 (27%), Positives = 43/90 (47%), Gaps = 10/90 (11%)
Query: 644 QLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLR 703
+L +A S ++C+ GE GD+G+ Q+ K+ +++ F+ +LGKL V +
Sbjct: 947 KLSNAIITSNPWICVSGELGDTGVMQIPKNLLEMTFE----------CQNLGKLTTVQIG 996
Query: 704 CEASDKSQYWYCEQVIVREPGTTSESIFTC 733
+ S W + V+VR T F C
Sbjct: 997 HDNSGLLAKWLVDCVMVRNEITGHTYRFPC 1026
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 61.6 bits (148), Expect = 4e-09
Identities = 40/117 (34%), Positives = 58/117 (49%), Gaps = 2/117 (1%)
Query: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEA-VH 100
+Y V + TG A + VYI + G+ G + +++L + F R TF L A
Sbjct: 1797 LYAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPL-FERNSRHTFILSAPAQ 1855
Query: 101 LGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVREL 157
LG L KI + HD GP GWF+ V++K+ T + F WL G D ++ REL
Sbjct: 1856 LGLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQCWLSAGRHDGRVEREL 1912
Score = 35.8 bits (81), Expect = 0.21
Identities = 29/100 (29%), Positives = 47/100 (47%), Gaps = 2/100 (2%)
Query: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAA-VSL 694
Y V + TG A S+V++ L G+ G S ++L + F+R F ++A L
Sbjct: 1798 YAVVIDTGFRAPARLTSKVYIVLCGDNGLSETKELSCPEKPL-FERNSRHTFILSAPAQL 1856
Query: 695 GKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTCQ 734
G L+K+ L ++ S W+ V+V+E T F Q
Sbjct: 1857 GLLRKIRLWHDSRGPSPGWFISHVMVKELHTGQGWFFPAQ 1896
>gi|239756622 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1732
Score = 58.2 bits (139), Expect = 4e-08
Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 5/151 (3%)
Query: 7 FYVPVQRWLARDQEDGEICR-EFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISI 65
FYV W AR ++ ++ + + +L+ P Y + V TG +A T A V I++
Sbjct: 710 FYVITVVW-ARKKDQADMQKVKVTVLADNDPSAQFH-YLIQVYTGYRRSAATTAKVVITL 767
Query: 66 HGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEA-VHLGDLCKIVIGHDGLGPGNGWFLDD 124
+G +G + L + + F RG D F L LG+L + + HD G W++
Sbjct: 768 YGSEGRSEPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQ 826
Query: 125 VVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
V++ D ++ F C+ WL DC++ R
Sbjct: 827 VIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 50.4 bits (119), Expect = 8e-06
Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 607 VWL-SRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDS 665
VW + QAD V ++ V+ Y + VYTG + A T ++V + L+G G S
Sbjct: 716 VWARKKDQADMQKV-KVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRS 774
Query: 666 GLRQLYKSNMQVKFQRGQIDKFQVAA-VSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
L V F+RG +D F + SLG L + L + S S WY QVIV +
Sbjct: 775 EPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMA 833
Query: 725 TTSESIFTC 733
+ F C
Sbjct: 834 VKRKWHFLC 842
Score = 30.8 bits (68), Expect = 6.9
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 9/83 (10%)
Query: 816 VLKRKESHGCTQELEWTVLAGELDGD------WKVTIVTGDLENAGTTATVFLYVYGETK 869
V RK+ Q+++ TVLA D D + + + TG +A TTA V + +YG
Sbjct: 716 VWARKKDQADMQKVKVTVLA---DNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEG 772
Query: 870 CSGPIILGSGKHQLFNPNTADIF 892
S P L + +F D+F
Sbjct: 773 RSEPHHLCDPQKTVFERGGLDVF 795
>gi|239751108 PREDICTED: polycystic kidney disease 1-like 3 [Homo
sapiens]
Length = 1731
Score = 58.2 bits (139), Expect = 4e-08
Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 5/151 (3%)
Query: 7 FYVPVQRWLARDQEDGEICR-EFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISI 65
FYV W AR ++ ++ + + +L+ P Y + V TG +A T A V I++
Sbjct: 710 FYVITVVW-ARKKDQADMQKVKVTVLADNDPSAQFH-YLIQVYTGYRRSAATTAKVVITL 767
Query: 66 HGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEA-VHLGDLCKIVIGHDGLGPGNGWFLDD 124
+G +G + L + + F RG D F L LG+L + + HD G W++
Sbjct: 768 YGSEGRSEPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQ 826
Query: 125 VVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
V++ D ++ F C+ WL DC++ R
Sbjct: 827 VIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 50.4 bits (119), Expect = 8e-06
Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 607 VWL-SRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDS 665
VW + QAD V ++ V+ Y + VYTG + A T ++V + L+G G S
Sbjct: 716 VWARKKDQADMQKV-KVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRS 774
Query: 666 GLRQLYKSNMQVKFQRGQIDKFQVAA-VSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
L V F+RG +D F + SLG L + L + S S WY QVIV +
Sbjct: 775 EPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMA 833
Query: 725 TTSESIFTC 733
+ F C
Sbjct: 834 VKRKWHFLC 842
Score = 30.8 bits (68), Expect = 6.9
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 9/83 (10%)
Query: 816 VLKRKESHGCTQELEWTVLAGELDGD------WKVTIVTGDLENAGTTATVFLYVYGETK 869
V RK+ Q+++ TVLA D D + + + TG +A TTA V + +YG
Sbjct: 716 VWARKKDQADMQKVKVTVLA---DNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEG 772
Query: 870 CSGPIILGSGKHQLFNPNTADIF 892
S P L + +F D+F
Sbjct: 773 RSEPHHLCDPQKTVFERGGLDVF 795
>gi|239745596 PREDICTED: polycystin 1-like 3 [Homo sapiens]
Length = 1731
Score = 58.2 bits (139), Expect = 4e-08
Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 5/151 (3%)
Query: 7 FYVPVQRWLARDQEDGEICR-EFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISI 65
FYV W AR ++ ++ + + +L+ P Y + V TG +A T A V I++
Sbjct: 710 FYVITVVW-ARKKDQADMQKVKVTVLADNDPSAQFH-YLIQVYTGYRRSAATTAKVVITL 767
Query: 66 HGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEA-VHLGDLCKIVIGHDGLGPGNGWFLDD 124
+G +G + L + + F RG D F L LG+L + + HD G W++
Sbjct: 768 YGSEGRSEPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQ 826
Query: 125 VVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
V++ D ++ F C+ WL DC++ R
Sbjct: 827 VIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 50.4 bits (119), Expect = 8e-06
Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 607 VWL-SRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDS 665
VW + QAD V ++ V+ Y + VYTG + A T ++V + L+G G S
Sbjct: 716 VWARKKDQADMQKV-KVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRS 774
Query: 666 GLRQLYKSNMQVKFQRGQIDKFQVAA-VSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
L V F+RG +D F + SLG L + L + S S WY QVIV +
Sbjct: 775 EPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMA 833
Query: 725 TTSESIFTC 733
+ F C
Sbjct: 834 VKRKWHFLC 842
Score = 30.8 bits (68), Expect = 6.9
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 9/83 (10%)
Query: 816 VLKRKESHGCTQELEWTVLAGELDGD------WKVTIVTGDLENAGTTATVFLYVYGETK 869
V RK+ Q+++ TVLA D D + + + TG +A TTA V + +YG
Sbjct: 716 VWARKKDQADMQKVKVTVLA---DNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEG 772
Query: 870 CSGPIILGSGKHQLFNPNTADIF 892
S P L + +F D+F
Sbjct: 773 RSEPHHLCDPQKTVFERGGLDVF 795
>gi|31559825 polycystin 1-like 3 [Homo sapiens]
Length = 1732
Score = 58.2 bits (139), Expect = 4e-08
Identities = 42/151 (27%), Positives = 71/151 (47%), Gaps = 5/151 (3%)
Query: 7 FYVPVQRWLARDQEDGEICR-EFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISI 65
FYV W AR ++ ++ + + +L+ P Y + V TG +A T A V I++
Sbjct: 710 FYVITVVW-ARKKDQADMQKVKVTVLADNDPSAQFH-YLIQVYTGYRRSAATTAKVVITL 767
Query: 66 HGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEA-VHLGDLCKIVIGHDGLGPGNGWFLDD 124
+G +G + L + + F RG D F L LG+L + + HD G W++
Sbjct: 768 YGSEGRSEPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQ 826
Query: 125 VVIKDPTTNYEYAFFCHRWLDQGEDDCKIVR 155
V++ D ++ F C+ WL DC++ R
Sbjct: 827 VIVCDMAVKRKWHFLCNCWLAVDLGDCELDR 857
Score = 50.4 bits (119), Expect = 8e-06
Identities = 41/129 (31%), Positives = 58/129 (44%), Gaps = 4/129 (3%)
Query: 607 VWL-SRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDS 665
VW + QAD V ++ V+ Y + VYTG + A T ++V + L+G G S
Sbjct: 716 VWARKKDQADMQKV-KVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRS 774
Query: 666 GLRQLYKSNMQVKFQRGQIDKFQVAA-VSLGKLQKVLLRCEASDKSQYWYCEQVIVREPG 724
L V F+RG +D F + SLG L + L + S S WY QVIV +
Sbjct: 775 EPHHLCDPQKTV-FERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMA 833
Query: 725 TTSESIFTC 733
+ F C
Sbjct: 834 VKRKWHFLC 842
Score = 30.8 bits (68), Expect = 6.9
Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 9/83 (10%)
Query: 816 VLKRKESHGCTQELEWTVLAGELDGD------WKVTIVTGDLENAGTTATVFLYVYGETK 869
V RK+ Q+++ TVLA D D + + + TG +A TTA V + +YG
Sbjct: 716 VWARKKDQADMQKVKVTVLA---DNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEG 772
Query: 870 CSGPIILGSGKHQLFNPNTADIF 892
S P L + +F D+F
Sbjct: 773 RSEPHHLCDPQKTVFERGGLDVF 795
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 57.8 bits (138), Expect = 5e-08
Identities = 36/111 (32%), Positives = 54/111 (48%), Gaps = 10/111 (9%)
Query: 47 VATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVHLGDLCK 106
V + +L + AN +I I GE G+T Q+ R+ F E +LG L
Sbjct: 961 VPSKKLGGSMFTANPWICISGELGETQIMQIPRNVLEMTF----------ECQNLGKLTT 1010
Query: 107 IVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIVREL 157
+ IGHD G W ++ V++++ T + Y F C RWL +G DD + R L
Sbjct: 1011 VQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERIL 1061
Score = 30.4 bits (67), Expect = 9.0
Identities = 20/79 (25%), Positives = 37/79 (46%), Gaps = 10/79 (12%)
Query: 655 FLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVSLGKLQKVLLRCEASDKSQYWY 714
++C+ GE G++ + Q+ ++ +++ F+ +LGKL V + + S W
Sbjct: 976 WICISGELGETQIMQIPRNVLEMTFE----------CQNLGKLTTVQIGHDNSGLYAKWL 1025
Query: 715 CEQVIVREPGTTSESIFTC 733
E V+VR T F C
Sbjct: 1026 VEYVMVRNEITGHTYKFPC 1044
>gi|5174633 receptor for egg jelly-like protein precursor [Homo
sapiens]
Length = 2253
Score = 57.0 bits (136), Expect = 9e-08
Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 6/140 (4%)
Query: 8 YVPVQRW-LARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIH 66
YV + W L RD+ D + +L P + Y V + TG W +GT ANV++ +
Sbjct: 1197 YVGLAFWALYRDEMDQHLRGHVIVLPDNDPYDNLC-YLVTIFTGSRWGSGTRANVFVQLR 1255
Query: 67 GEKGDTGSRQLFRSKSSFNFL-RGQTDTFFLEAVH-LGDLCKIVIGHDGLGPGNGWFLDD 124
G + L S F L RG +TF L LGD+ I + H+ G W+L
Sbjct: 1256 GTVSTSDVHCL--SHPHFTTLYRGSINTFLLTTKSDLGDIHSIRVWHNNEGRSPSWYLSR 1313
Query: 125 VVIKDPTTNYEYAFFCHRWL 144
+ +++ + + + F C +WL
Sbjct: 1314 IKVENLFSRHIWLFICQKWL 1333
>gi|116006951 polycystin 1-like 2 isoform a [Homo sapiens]
Length = 2459
Score = 55.5 bits (132), Expect = 3e-07
Identities = 39/145 (26%), Positives = 61/145 (42%), Gaps = 3/145 (2%)
Query: 8 YVPVQRWLARDQEDGEICREFPLLSKGQPVLPVTIYEVNVATGELWNAGTVANVYISIHG 67
YV V W R + + +L P Y V V TG A T + V ++++G
Sbjct: 1358 YVLVVIWARRKDAQDQAKVKVTVLEDNDPFAQYH-YLVTVYTGHRRGAATSSKVTVTLYG 1416
Query: 68 EKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVH-LGDLCKIVIGHDGLGPGNGWFLDDVV 126
G+ L + F RG D F L + LG+L + + HD G W++ V+
Sbjct: 1417 LDGEREPHHLADPDTPV-FERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVL 1475
Query: 127 IKDPTTNYEYAFFCHRWLDQGEDDC 151
+ D + ++ F C+ WL DC
Sbjct: 1476 VYDLVMDRKWYFLCNSWLSINVGDC 1500
Score = 52.4 bits (124), Expect = 2e-06
Identities = 36/130 (27%), Positives = 60/130 (46%), Gaps = 2/130 (1%)
Query: 607 VWLSRIQADGDVVCELPVVKGGQAIFPLRYQVDVYTGQLKHAETESEVFLCLFGERGDSG 666
+W R A ++ V++ Y V VYTG + A T S+V + L+G G+
Sbjct: 1363 IWARRKDAQDQAKVKVTVLEDNDPFAQYHYLVTVYTGHRRGAATSSKVTVTLYGLDGERE 1422
Query: 667 LRQLYKSNMQVKFQRGQIDKFQVAAV-SLGKLQKVLLRCEASDKSQYWYCEQVIVREPGT 725
L + V F+RG +D F ++ + LG+L+ + L + S WY +V+V +
Sbjct: 1423 PHHLADPDTPV-FERGAVDAFLLSTLFPLGELRSLRLWHDNSGDRPSWYVSRVLVYDLVM 1481
Query: 726 TSESIFTCQS 735
+ F C S
Sbjct: 1482 DRKWYFLCNS 1491
>gi|205360962 polycystin 1 isoform 2 precursor [Homo sapiens]
Length = 4302
Score = 54.7 bits (130), Expect = 4e-07
Identities = 35/103 (33%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 43 YEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVH-L 101
YE+ V TG +GT A+V I ++G +G R L ++ F R D F + H L
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA---FHRNSLDIFRIATPHSL 3176
Query: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWL 144
G + KI + HD G WFL V+++D T F + WL
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWL 3219
Score = 40.8 bits (94), Expect = 0.007
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 4/98 (4%)
Query: 635 RYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAV-S 693
+Y++ V TG + + T + V + L+G SG R L F R +D F++A S
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA---FHRNSLDIFRIATPHS 3175
Query: 694 LGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIF 731
LG + K+ + + S W+ + VIVR+ T + F
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFF 3213
>gi|205360954 polycystin 1 isoform 1 precursor [Homo sapiens]
Length = 4303
Score = 54.7 bits (130), Expect = 4e-07
Identities = 35/103 (33%), Positives = 50/103 (48%), Gaps = 4/103 (3%)
Query: 43 YEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEAVH-L 101
YE+ V TG +GT A+V I ++G +G R L ++ F R D F + H L
Sbjct: 3120 YEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA---FHRNSLDIFRIATPHSL 3176
Query: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWL 144
G + KI + HD G WFL V+++D T F + WL
Sbjct: 3177 GSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFFLVNDWL 3219
Score = 40.8 bits (94), Expect = 0.007
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 4/98 (4%)
Query: 635 RYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAV-S 693
+Y++ V TG + + T + V + L+G SG R L F R +D F++A S
Sbjct: 3119 KYEILVKTGWGRGSGTTAHVGIMLYGVDSRSGHRHLDGDRA---FHRNSLDIFRIATPHS 3175
Query: 694 LGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIF 731
LG + K+ + + S W+ + VIVR+ T + F
Sbjct: 3176 LGSVWKIRVWHDNKGLSPAWFLQHVIVRDLQTARSAFF 3213
>gi|4502057 arachidonate 5-lipoxygenase [Homo sapiens]
Length = 674
Score = 48.1 bits (113), Expect = 4e-05
Identities = 38/127 (29%), Positives = 59/127 (46%), Gaps = 10/127 (7%)
Query: 43 YEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLEA-VHL 101
Y V VATG W AGT +Y+S+ G G + L +F RG D++ + L
Sbjct: 4 YTVTVATGSQWFAGTDDYIYLSLVGSAG-CSEKHLLDKPFYNDFERGAVDSYDVTVDEEL 62
Query: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGEDDCKIV----REL 157
G++ + I + W+L + +K P +Y F C+RW+ D ++V R
Sbjct: 63 GEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDY-IEFPCYRWI---TGDVEVVLRDGRAK 118
Query: 158 YARDNSI 164
ARD+ I
Sbjct: 119 LARDDQI 125
>gi|154426292 arachidonate 12-lipoxygenase [Homo sapiens]
Length = 663
Score = 47.0 bits (110), Expect = 9e-05
Identities = 32/100 (32%), Positives = 51/100 (51%), Gaps = 7/100 (7%)
Query: 635 RYQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQV-AAVS 693
RY++ V TG + + + V L L G RG++ L +Q++ RG+ ++F A
Sbjct: 3 RYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELE------LQLRPARGEEEEFDHDVAED 56
Query: 694 LGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
LG LQ V LR W+C+++ V+ PG +E F C
Sbjct: 57 LGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPC 96
Score = 39.3 bits (90), Expect = 0.019
Identities = 31/108 (28%), Positives = 49/108 (45%), Gaps = 8/108 (7%)
Query: 43 YEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLE-AVHL 101
Y + VATG +G+ V + + G +G+ R RG+ + F + A L
Sbjct: 4 YRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPA------RGEEEEFDHDVAEDL 57
Query: 102 GDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLDQGED 149
G L + + + WF D + ++ P E AF C+RW+ QGED
Sbjct: 58 GLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWV-QGED 104
>gi|40316937 arachidonate 15-lipoxygenase [Homo sapiens]
Length = 662
Score = 39.7 bits (91), Expect = 0.015
Identities = 30/100 (30%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGL-RQLYKSNMQVKFQRGQIDKFQVAAVS- 693
Y++ V TG +A + ++V L L G+ G++ L ++L+ + RG+ + +V
Sbjct: 4 YRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPA-------RGKETELKVEVPEY 56
Query: 694 LGKLQKVLLRCEASDKSQYWYCEQVIVREPGTTSESIFTC 733
LG L V LR K W+C + V+ PG E F C
Sbjct: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPC 96
Score = 35.8 bits (81), Expect = 0.21
Identities = 23/105 (21%), Positives = 49/105 (46%), Gaps = 7/105 (6%)
Query: 42 IYEVNVATGELWNAGTVANVYISIHGEKGDTG-SRQLFRSKSSFNFLRGQTDTFFLEAVH 100
+Y + V+TG AG+ V + + G+ G+ ++L+ ++ L+ + +
Sbjct: 3 LYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEY------ 56
Query: 101 LGDLCKIVIGHDGLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLD 145
LG L + + L + WF + + ++ P E F C+RW++
Sbjct: 57 LGPLLFVKLRKRHLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVE 101
>gi|182765464 arachidonate lipoxygenase 3 [Homo sapiens]
Length = 711
Score = 37.0 bits (84), Expect = 0.096
Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 6/101 (5%)
Query: 636 YQVDVYTGQLKHAETESEVFLCLFGERGDSGLRQLYKSNMQVKFQRGQIDKFQVAAVS-L 694
Y++ V TG A T + + L G G+S ++L M F G + K++V + L
Sbjct: 4 YRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRL--DRMGRDFAPGSVQKYKVRCTAEL 61
Query: 695 GKLQKVLLRCE--ASDKSQYWYCEQVIVREPGTTSESIFTC 733
G+L + + E A + WYC ++ V EP S S F C
Sbjct: 62 GELLLLRVHKERYAFFRKDSWYCSRICVTEP-DGSVSHFPC 101
Score = 34.3 bits (77), Expect = 0.62
Identities = 21/109 (19%), Positives = 52/109 (47%), Gaps = 6/109 (5%)
Query: 40 VTIYEVNVATGELWNAGTVANVYISIHGEKGDTGSRQLFRSKSSFNFLRGQTDTFFLE-A 98
+ +Y + V TG AGT+ N+ +++ G G++ ++L + +F G + +
Sbjct: 1 MAVYRLCVTTGPYLRAGTLDNISVTLVGTCGESPKQRL--DRMGRDFAPGSVQKYKVRCT 58
Query: 99 VHLGDLCKIVIGHD--GLGPGNGWFLDDVVIKDPTTNYEYAFFCHRWLD 145
LG+L + + + + W+ + + +P + + F C++W++
Sbjct: 59 AELGELLLLRVHKERYAFFRKDSWYCSRICVTEPDGSVSH-FPCYQWIE 106
>gi|8923374 dihydrouridine synthase 2-like, SMM1 homolog [Homo
sapiens]
Length = 493
Score = 34.7 bits (78), Expect = 0.48
Identities = 30/94 (31%), Positives = 39/94 (41%), Gaps = 19/94 (20%)
Query: 911 VSVENPCSNTVPACCLMLF--LEKREGSVQHATEDSQLQITTVDDRKGHKRCKCEALGDS 968
V +N +NT C ML LE +G + HA + S R CEA G
Sbjct: 272 VQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSS--------------REICEAFGLG 317
Query: 969 AYKEEHTQEIDILR---RVKEDMASRNPQEDPGG 999
A+ EE TQE+D + K + P ED G
Sbjct: 318 AFYEETTQELDAQQARLSAKTSEQTGEPAEDTSG 351
>gi|153285461 fibroblast growth factor 2 [Homo sapiens]
Length = 288
Score = 34.3 bits (77), Expect = 0.62
Identities = 14/29 (48%), Positives = 20/29 (68%)
Query: 226 QFYNKLTGGFVRLHPDGTVDAIGEKTDKY 254
+ Y K G F+R+HPDG VD + EK+D +
Sbjct: 164 RLYCKNGGFFLRIHPDGRVDGVREKSDPH 192
>gi|4503701 fibroblast growth factor 4 precursor [Homo sapiens]
Length = 206
Score = 34.3 bits (77), Expect = 0.62
Identities = 23/90 (25%), Positives = 39/90 (43%), Gaps = 1/90 (1%)
Query: 371 PDGSCTGVGSQSEKSYWKVHKISSGICMFESVKNAQMYLRIKDGRCDGTGTGDVDCHFKI 430
PDG G + + S ++ + G+ V + G+ G+ +C FK
Sbjct: 100 PDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFK- 158
Query: 431 KKNLKNASISLESTKSPGLFVGLQSDGQAK 460
+ L N + ES K PG+F+ L +G+ K
Sbjct: 159 EILLPNNYNAYESYKYPGMFIALSKNGKTK 188
>gi|223941891 protein tyrosine phosphatase, non-receptor type 3
isoform 6 [Homo sapiens]
Length = 581
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 11/55 (20%)
Query: 866 GETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIMARNETCNVCTVSVENPCSNT 920
G TKC HQ + P+ D+ G FHI ++E C + VS E +NT
Sbjct: 418 GRTKC----------HQYW-PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT 461
>gi|223941888 protein tyrosine phosphatase, non-receptor type 3
isoform 5 [Homo sapiens]
Length = 626
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 11/55 (20%)
Query: 866 GETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIMARNETCNVCTVSVENPCSNT 920
G TKC HQ + P+ D+ G FHI ++E C + VS E +NT
Sbjct: 463 GRTKC----------HQYW-PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT 506
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 11/55 (20%)
Query: 866 GETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIMARNETCNVCTVSVENPCSNT 920
G TKC HQ + P+ D+ G FHI ++E C + VS E +NT
Sbjct: 574 GRTKC----------HQYW-PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT 617
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 11/55 (20%)
Query: 866 GETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIMARNETCNVCTVSVENPCSNT 920
G TKC HQ + P+ D+ G FHI ++E C + VS E +NT
Sbjct: 619 GRTKC----------HQYW-PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT 662
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 11/55 (20%)
Query: 866 GETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIMARNETCNVCTVSVENPCSNT 920
G TKC HQ + P+ D+ G FHI ++E C + VS E +NT
Sbjct: 705 GRTKC----------HQYW-PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT 748
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 32.7 bits (73), Expect = 1.8
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 11/55 (20%)
Query: 866 GETKCSGPIILGSGKHQLFNPNTADIFKKGKFHIMARNETCNVCTVSVENPCSNT 920
G TKC HQ + P+ D+ G FHI ++E C + VS E +NT
Sbjct: 750 GRTKC----------HQYW-PDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT 793
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,124,378
Number of Sequences: 37866
Number of extensions: 1832146
Number of successful extensions: 4914
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 27
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 4621
Number of HSP's gapped (non-prelim): 180
length of query: 1029
length of database: 18,247,518
effective HSP length: 112
effective length of query: 917
effective length of database: 14,006,526
effective search space: 12843984342
effective search space used: 12843984342
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.