Guide to the Human Genome
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Search of human proteins with 239742602

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239742602 PREDICTED: ankyrin repeat and death domain
containing 1B [Homo sapiens]
         (607 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239742602 PREDICTED: ankyrin repeat and death domain containi...  1210   0.0  
gi|239754056 PREDICTED: ankyrin repeat and death domain containi...  1041   0.0  
gi|239748583 PREDICTED: ankyrin repeat and death domain containi...  1041   0.0  
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   324   2e-88
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       154   2e-37
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        154   2e-37
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        154   2e-37
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       148   1e-35
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        148   1e-35
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        148   1e-35
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        148   1e-35
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        148   1e-35
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        145   1e-34
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   144   3e-34
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  138   2e-32
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   135   1e-31
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   134   2e-31
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   131   2e-30
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    125   9e-29
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   119   6e-27
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          117   3e-26
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   113   6e-25
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   113   6e-25
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   108   1e-23
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    108   1e-23
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   106   5e-23
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   106   5e-23
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                    105   2e-22
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   103   5e-22
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            102   8e-22

>gi|239742602 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 607

 Score = 1210 bits (3130), Expect = 0.0
 Identities = 607/607 (100%), Positives = 607/607 (100%)

Query: 1   MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
           MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA
Sbjct: 1   MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60

Query: 61  GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL
Sbjct: 61  GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV
Sbjct: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
           RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW
Sbjct: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
           TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL
Sbjct: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300

Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
           AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT
Sbjct: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360

Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
           VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS
Sbjct: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420

Query: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
           RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH
Sbjct: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480

Query: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIWLHGTLMTQGDPAKQL 540
           QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIWLHGTLMTQGDPAKQL
Sbjct: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIWLHGTLMTQGDPAKQL 540

Query: 541 YEELEAVYRNIILTSYSPSVVLAVAHTEYGTMEGACKLSAASPLGNDPVNTGYSLAWQFC 600
           YEELEAVYRNIILTSYSPSVVLAVAHTEYGTMEGACKLSAASPLGNDPVNTGYSLAWQFC
Sbjct: 541 YEELEAVYRNIILTSYSPSVVLAVAHTEYGTMEGACKLSAASPLGNDPVNTGYSLAWQFC 600

Query: 601 VIPLLSI 607
           VIPLLSI
Sbjct: 601 VIPLLSI 607


>gi|239754056 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score = 1041 bits (2693), Expect = 0.0
 Identities = 524/524 (100%), Positives = 524/524 (100%)

Query: 1   MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
           MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA
Sbjct: 1   MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60

Query: 61  GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL
Sbjct: 61  GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV
Sbjct: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
           RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW
Sbjct: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
           TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL
Sbjct: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300

Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
           AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT
Sbjct: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360

Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
           VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS
Sbjct: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420

Query: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
           RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH
Sbjct: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480

Query: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
           QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI
Sbjct: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524


>gi|239748583 PREDICTED: ankyrin repeat and death domain containing
           1B [Homo sapiens]
          Length = 524

 Score = 1041 bits (2693), Expect = 0.0
 Identities = 524/524 (100%), Positives = 524/524 (100%)

Query: 1   MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60
           MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA
Sbjct: 1   MDPAGRARGQGATAGGLLLRAAAAAKGLREDLWGAAALPWRSLSRIPKREGLGEEDTAVA 60

Query: 61  GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL
Sbjct: 61  GHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV
Sbjct: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
           RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW
Sbjct: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
           TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL
Sbjct: 241 TAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300

Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
           AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT
Sbjct: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360

Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
           VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS
Sbjct: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420

Query: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480
           RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH
Sbjct: 421 RSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYH 480

Query: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524
           QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI
Sbjct: 481 QLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLI 524


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  324 bits (830), Expect = 2e-88
 Identities = 193/499 (38%), Positives = 282/499 (56%), Gaps = 34/499 (6%)

Query: 65  LLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHK 124
           LLP ER    AA+ NN+  M++L  ++VN    N++ R ALH+A G  H  AV  LL+H+
Sbjct: 12  LLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHE 71

Query: 125 ARVDVADK----------HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFA 174
           A VD  D            G+  + L+AW G L ++ +LV +GA    +++DG++ LH A
Sbjct: 72  AAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCA 131

Query: 175 TQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKI 234
            Q  HV ++ ++++DL    L+  D+ GR  F  AAE G ++ ++ L       + KDK 
Sbjct: 132 AQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE 191

Query: 235 QWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSP 294
             + L  AA       R  +A L  +     G  +   +      G TALH AA   H  
Sbjct: 192 GNTALHLAA------GRGHMAVL--QRLVDIGLDLEEQNAE----GLTALHSAAGGSHPD 239

Query: 295 AVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE----NVDLHQKVEPKESPL 350
            VQ+LL     +N + + N+S L  A  +G   +   L+      NV  HQ      SPL
Sbjct: 240 CVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGA----SPL 295

Query: 351 HLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDK 410
           HL V +N   +V  L+++  D++ ++ +QQTPLH+AA+    ++ + LL AG DL   DK
Sbjct: 296 HLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDK 355

Query: 411 QGKTALAVASRSNHSLVVGMLIKAERYYAWREEHHESIRDPSTGFTLTFKQDHSLETRHI 470
           QGKTALAVA RSNH  +V M+IKA+R+Y W ++H     DPS G +L+FKQDH  ET+ +
Sbjct: 356 QGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPS---DPS-GKSLSFKQDHRQETQQL 411

Query: 471 RTLLWDLAYHQLKANEWQRLARSWNFTDDQIRAIEEQWSGNESFREHGHRALLIWLHGTL 530
           R++LW LA   L+  EW++LA SW FT+  + AIE+QW+G  S++EHGHR LLIWLHG  
Sbjct: 412 RSVLWRLASRYLQPREWKKLAYSWEFTEAHVDAIEQQWTGTRSYQEHGHRMLLIWLHGVA 471

Query: 531 MTQGDPAKQLYEELEAVYR 549
               +P+K L+E L A+ R
Sbjct: 472 TAGENPSKALFEGLVAIGR 490


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  154 bits (390), Expect = 2e-37
 Identities = 112/392 (28%), Positives = 187/392 (47%), Gaps = 35/392 (8%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA++ NLD + +  +  ++IN  N     ALH A    H+  V  LL   + VD A
Sbjct: 13  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 72

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+A+ +G  EV+ +LVK GA+  A++Q+G + L+ A Q NH+ +V+YL++  
Sbjct: 73  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE-- 130

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
           +  + +   E G  P  +A ++GH + +  L    L    K K++   L  AA       
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKS 186

Query: 244 -------------LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG---------GN 281
                         +KM  +R + +  T     +    V+ +++ L +G         G 
Sbjct: 187 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 246

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T LH+A+K G++  V++LL +   I+      ++ L  A R+GH  +V  LL     L  
Sbjct: 247 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 306

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
           + +   SPLH+    +H+  V  LL  +  +D +     T LHVAA  G+  + + LL  
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             +  A    G T L +A + N   V+ +L+K
Sbjct: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVK 398



 Score =  139 bits (351), Expect = 6e-33
 Identities = 105/394 (26%), Positives = 177/394 (44%), Gaps = 29/394 (7%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N + +ME L +   +I  +     T +H A    HL+ V  L
Sbjct: 370 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 429

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L++ A  DV +  G T +H+AA +G +EV+  L++ GA   A+ ++  + LH A++    
Sbjct: 430 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 489

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            IV+ L+Q  H+   +     G  P  ++A  G V++   L       S   K  ++ L 
Sbjct: 490 EIVQLLLQ--HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 547

Query: 241 TAA------LTKMKTSRNSIAALTIEGACSP---GTGVSTSSVSLL------------QG 279
            AA      + K+   R + A    +   +P           V+LL            + 
Sbjct: 548 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 607

Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
           G T LH+AAK         LL    + N + +  ++ L +A++ GH  +V  LL +  ++
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667

Query: 340 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
           H   +   + LHL    + + V + L     D D   +   TPL VA   GNV++V  LL
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727

Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           K G ++ A  K G T L  A++  H+ ++ +L++
Sbjct: 728 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761



 Score =  132 bits (331), Expect = 1e-30
 Identities = 89/359 (24%), Positives = 173/359 (48%), Gaps = 14/359 (3%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   +  + + L +K+ N N       T LH A  +N +  ++ L+K+ A +    + G
Sbjct: 351 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 410

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
           LT IH+AA+ G L ++L+L++ GA     N  G +ALH A ++  V +V  L+++  L D
Sbjct: 411 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 470

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
               +E  + P  +A+  G  E+++ L     H        ++ L  +A    +  +  +
Sbjct: 471 ARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA----REGQVDV 524

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
           A++ +E   +             + G T LH+AAK+G     ++LL +    +   +  +
Sbjct: 525 ASVLLEAGAAHSLAT--------KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 576

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
           + L +A    +  +   LL +    H   +   +PLH+    N + + ++LL+   + +I
Sbjct: 577 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 636

Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + ++  TPLH+A+  G+ ++V  LL  G ++    K G T+L +A++ +   V  +L K
Sbjct: 637 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 695



 Score =  113 bits (283), Expect = 4e-25
 Identities = 86/345 (24%), Positives = 150/345 (43%), Gaps = 47/345 (13%)

Query: 89  EKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE 148
           + K+ +N       T LH A    +++    LL   A VD   ++G+T +H+A+  G+  
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259

Query: 149 VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLL 208
           ++ +L+  G    AK +DG++ LH A +S H ++VE L++      L    + G  P  +
Sbjct: 260 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGAPLLARTKNGLSPLHM 317

Query: 209 AAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG 268
           AA+  HVE ++ L     H +  D +    L                             
Sbjct: 318 AAQGDHVECVKHLL---QHKAPVDDVTLDYL----------------------------- 345

Query: 269 VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASL 328
                        TALH+AA  GH    ++LL +  + N       + L IA +     +
Sbjct: 346 -------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 392

Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
           +  L+     +    E   +P+H+     H+ +V  LL      D+ N + +T LH+AA 
Sbjct: 393 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452

Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            G VE+V  LL+ G  + A  ++ +T L +ASR   + +V +L++
Sbjct: 453 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497



 Score =  106 bits (265), Expect = 5e-23
 Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 56/415 (13%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AAK  ++ L+++L  +  +++       TALH A        V  L+K  A ++   ++G
Sbjct: 50  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 109

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
            T +++AA    ++V+  L++ GA+Q    +DG + L  A Q  H + V  L+++     
Sbjct: 110 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169

Query: 190 -----LHL---KD----------------------LNQPDEKGRKPFLLAAERGHVEMIE 219
                LH+   KD                      +N+  E G  P  +AA  G+V +  
Sbjct: 170 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 229

Query: 220 KLTFLNLHTSEKDKIQWSTLWTAA------LTKMKTSRNS-IAALTIEGA----CSPGTG 268
            L           +   + L  A+      + K+   R   I A T +G     C+  +G
Sbjct: 230 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 289

Query: 269 VSTSSVSLLQ----------GGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
                  LL+           G + LH+AA+  H   V+ LL     ++++    +++L 
Sbjct: 290 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 349

Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
           +A   GH  +   LL +  + + +     +PLH+    N I V+  L+     I  + + 
Sbjct: 350 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 409

Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             TP+HVAA  G++ +V  LL+ G      + +G+TAL +A+R+    VV  L++
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 464



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 49/190 (25%), Positives = 90/190 (47%), Gaps = 2/190 (1%)

Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
           N +   AA+ G+   V   L    DIN  N+  +++L +A + GH  LV  LL     + 
Sbjct: 11  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 70

Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
              +   + LH+  +     VV  L+    +I+  +Q   TPL++AA   ++++V+ LL+
Sbjct: 71  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 130

Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWR--EEHHESIRDPSTGFTLT 458
            G +     + G T LAVA +  H+  V +L++ +     R    H  + +D +    L 
Sbjct: 131 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 190

Query: 459 FKQDHSLETR 468
            + DH+ + +
Sbjct: 191 LQNDHNADVQ 200


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  154 bits (390), Expect = 2e-37
 Identities = 112/392 (28%), Positives = 187/392 (47%), Gaps = 35/392 (8%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA++ NLD + +  +  ++IN  N     ALH A    H+  V  LL   + VD A
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+A+ +G  EV+ +LVK GA+  A++Q+G + L+ A Q NH+ +V+YL++  
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE-- 151

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
           +  + +   E G  P  +A ++GH + +  L    L    K K++   L  AA       
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKS 207

Query: 244 -------------LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG---------GN 281
                         +KM  +R + +  T     +    V+ +++ L +G         G 
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T LH+A+K G++  V++LL +   I+      ++ L  A R+GH  +V  LL     L  
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
           + +   SPLH+    +H+  V  LL  +  +D +     T LHVAA  G+  + + LL  
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             +  A    G T L +A + N   V+ +L+K
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVK 419



 Score =  139 bits (351), Expect = 6e-33
 Identities = 105/394 (26%), Positives = 177/394 (44%), Gaps = 29/394 (7%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N + +ME L +   +I  +     T +H A    HL+ V  L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L++ A  DV +  G T +H+AA +G +EV+  L++ GA   A+ ++  + LH A++    
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            IV+ L+Q  H+   +     G  P  ++A  G V++   L       S   K  ++ L 
Sbjct: 511 EIVQLLLQ--HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568

Query: 241 TAA------LTKMKTSRNSIAALTIEGACSP---GTGVSTSSVSLL------------QG 279
            AA      + K+   R + A    +   +P           V+LL            + 
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628

Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
           G T LH+AAK         LL    + N + +  ++ L +A++ GH  +V  LL +  ++
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 340 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
           H   +   + LHL    + + V + L     D D   +   TPL VA   GNV++V  LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           K G ++ A  K G T L  A++  H+ ++ +L++
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782



 Score =  132 bits (331), Expect = 1e-30
 Identities = 89/359 (24%), Positives = 173/359 (48%), Gaps = 14/359 (3%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   +  + + L +K+ N N       T LH A  +N +  ++ L+K+ A +    + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
           LT IH+AA+ G L ++L+L++ GA     N  G +ALH A ++  V +V  L+++  L D
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
               +E  + P  +A+  G  E+++ L     H        ++ L  +A    +  +  +
Sbjct: 492 ARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA----REGQVDV 545

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
           A++ +E   +             + G T LH+AAK+G     ++LL +    +   +  +
Sbjct: 546 ASVLLEAGAAHSLAT--------KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
           + L +A    +  +   LL +    H   +   +PLH+    N + + ++LL+   + +I
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + ++  TPLH+A+  G+ ++V  LL  G ++    K G T+L +A++ +   V  +L K
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716



 Score =  113 bits (283), Expect = 4e-25
 Identities = 86/345 (24%), Positives = 150/345 (43%), Gaps = 47/345 (13%)

Query: 89  EKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE 148
           + K+ +N       T LH A    +++    LL   A VD   ++G+T +H+A+  G+  
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280

Query: 149 VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLL 208
           ++ +L+  G    AK +DG++ LH A +S H ++VE L++      L    + G  P  +
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGAPLLARTKNGLSPLHM 338

Query: 209 AAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG 268
           AA+  HVE ++ L     H +  D +    L                             
Sbjct: 339 AAQGDHVECVKHLL---QHKAPVDDVTLDYL----------------------------- 366

Query: 269 VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASL 328
                        TALH+AA  GH    ++LL +  + N       + L IA +     +
Sbjct: 367 -------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413

Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
           +  L+     +    E   +P+H+     H+ +V  LL      D+ N + +T LH+AA 
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            G VE+V  LL+ G  + A  ++ +T L +ASR   + +V +L++
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518



 Score =  106 bits (265), Expect = 5e-23
 Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 56/415 (13%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AAK  ++ L+++L  +  +++       TALH A        V  L+K  A ++   ++G
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
            T +++AA    ++V+  L++ GA+Q    +DG + L  A Q  H + V  L+++     
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 190 -----LHL---KD----------------------LNQPDEKGRKPFLLAAERGHVEMIE 219
                LH+   KD                      +N+  E G  P  +AA  G+V +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 220 KLTFLNLHTSEKDKIQWSTLWTAA------LTKMKTSRNS-IAALTIEGA----CSPGTG 268
            L           +   + L  A+      + K+   R   I A T +G     C+  +G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310

Query: 269 VSTSSVSLLQ----------GGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
                  LL+           G + LH+AA+  H   V+ LL     ++++    +++L 
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370

Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
           +A   GH  +   LL +  + + +     +PLH+    N I V+  L+     I  + + 
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430

Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             TP+HVAA  G++ +V  LL+ G      + +G+TAL +A+R+    VV  L++
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 49/190 (25%), Positives = 90/190 (47%), Gaps = 2/190 (1%)

Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
           N +   AA+ G+   V   L    DIN  N+  +++L +A + GH  LV  LL     + 
Sbjct: 32  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91

Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
              +   + LH+  +     VV  L+    +I+  +Q   TPL++AA   ++++V+ LL+
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWR--EEHHESIRDPSTGFTLT 458
            G +     + G T LAVA +  H+  V +L++ +     R    H  + +D +    L 
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 459 FKQDHSLETR 468
            + DH+ + +
Sbjct: 212 LQNDHNADVQ 221


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  154 bits (390), Expect = 2e-37
 Identities = 112/392 (28%), Positives = 187/392 (47%), Gaps = 35/392 (8%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA++ NLD + +  +  ++IN  N     ALH A    H+  V  LL   + VD A
Sbjct: 34  SFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSA 93

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+A+ +G  EV+ +LVK GA+  A++Q+G + L+ A Q NH+ +V+YL++  
Sbjct: 94  TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE-- 151

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
           +  + +   E G  P  +A ++GH + +  L    L    K K++   L  AA       
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAIL----LENDTKGKVRLPALHIAARKDDTKS 207

Query: 244 -------------LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG---------GN 281
                         +KM  +R + +  T     +    V+ +++ L +G         G 
Sbjct: 208 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 267

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T LH+A+K G++  V++LL +   I+      ++ L  A R+GH  +V  LL     L  
Sbjct: 268 TPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLA 327

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
           + +   SPLH+    +H+  V  LL  +  +D +     T LHVAA  G+  + + LL  
Sbjct: 328 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 387

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             +  A    G T L +A + N   V+ +L+K
Sbjct: 388 RANPNARALNGFTPLHIACKKNRIKVMELLVK 419



 Score =  139 bits (351), Expect = 6e-33
 Identities = 105/394 (26%), Positives = 177/394 (44%), Gaps = 29/394 (7%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N + +ME L +   +I  +     T +H A    HL+ V  L
Sbjct: 391 PNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLL 450

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L++ A  DV +  G T +H+AA +G +EV+  L++ GA   A+ ++  + LH A++    
Sbjct: 451 LQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKT 510

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            IV+ L+Q  H+   +     G  P  ++A  G V++   L       S   K  ++ L 
Sbjct: 511 EIVQLLLQ--HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLH 568

Query: 241 TAA------LTKMKTSRNSIAALTIEGACSP---GTGVSTSSVSLL------------QG 279
            AA      + K+   R + A    +   +P           V+LL            + 
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628

Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
           G T LH+AAK         LL    + N + +  ++ L +A++ GH  +V  LL +  ++
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688

Query: 340 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
           H   +   + LHL    + + V + L     D D   +   TPL VA   GNV++V  LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748

Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           K G ++ A  K G T L  A++  H+ ++ +L++
Sbjct: 749 KQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782



 Score =  132 bits (331), Expect = 1e-30
 Identities = 89/359 (24%), Positives = 173/359 (48%), Gaps = 14/359 (3%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   +  + + L +K+ N N       T LH A  +N +  ++ L+K+ A +    + G
Sbjct: 372 AAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESG 431

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
           LT IH+AA+ G L ++L+L++ GA     N  G +ALH A ++  V +V  L+++  L D
Sbjct: 432 LTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD 491

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
               +E  + P  +A+  G  E+++ L     H        ++ L  +A    +  +  +
Sbjct: 492 ARAREE--QTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISA----REGQVDV 545

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
           A++ +E   +             + G T LH+AAK+G     ++LL +    +   +  +
Sbjct: 546 ASVLLEAGAAHSLAT--------KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
           + L +A    +  +   LL +    H   +   +PLH+    N + + ++LL+   + +I
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657

Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + ++  TPLH+A+  G+ ++V  LL  G ++    K G T+L +A++ +   V  +L K
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTK 716



 Score =  113 bits (283), Expect = 4e-25
 Identities = 86/345 (24%), Positives = 150/345 (43%), Gaps = 47/345 (13%)

Query: 89  EKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE 148
           + K+ +N       T LH A    +++    LL   A VD   ++G+T +H+A+  G+  
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280

Query: 149 VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLL 208
           ++ +L+  G    AK +DG++ LH A +S H ++VE L++      L    + G  P  +
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLE--RGAPLLARTKNGLSPLHM 338

Query: 209 AAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG 268
           AA+  HVE ++ L     H +  D +    L                             
Sbjct: 339 AAQGDHVECVKHLL---QHKAPVDDVTLDYL----------------------------- 366

Query: 269 VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASL 328
                        TALH+AA  GH    ++LL +  + N       + L IA +     +
Sbjct: 367 -------------TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKV 413

Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
           +  L+     +    E   +P+H+     H+ +V  LL      D+ N + +T LH+AA 
Sbjct: 414 MELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473

Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            G VE+V  LL+ G  + A  ++ +T L +ASR   + +V +L++
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518



 Score =  106 bits (265), Expect = 5e-23
 Identities = 99/415 (23%), Positives = 179/415 (43%), Gaps = 56/415 (13%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AAK  ++ L+++L  +  +++       TALH A        V  L+K  A ++   ++G
Sbjct: 71  AAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG 130

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
            T +++AA    ++V+  L++ GA+Q    +DG + L  A Q  H + V  L+++     
Sbjct: 131 FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190

Query: 190 -----LHL---KD----------------------LNQPDEKGRKPFLLAAERGHVEMIE 219
                LH+   KD                      +N+  E G  P  +AA  G+V +  
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVAT 250

Query: 220 KLTFLNLHTSEKDKIQWSTLWTAA------LTKMKTSRNS-IAALTIEGA----CSPGTG 268
            L           +   + L  A+      + K+   R   I A T +G     C+  +G
Sbjct: 251 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 310

Query: 269 VSTSSVSLLQ----------GGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
                  LL+           G + LH+AA+  H   V+ LL     ++++    +++L 
Sbjct: 311 HDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALH 370

Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
           +A   GH  +   LL +  + + +     +PLH+    N I V+  L+     I  + + 
Sbjct: 371 VAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITES 430

Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             TP+HVAA  G++ +V  LL+ G      + +G+TAL +A+R+    VV  L++
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLR 485



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 49/190 (25%), Positives = 90/190 (47%), Gaps = 2/190 (1%)

Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
           N +   AA+ G+   V   L    DIN  N+  +++L +A + GH  LV  LL     + 
Sbjct: 32  NASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVD 91

Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
              +   + LH+  +     VV  L+    +I+  +Q   TPL++AA   ++++V+ LL+
Sbjct: 92  SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE 151

Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWR--EEHHESIRDPSTGFTLT 458
            G +     + G T LAVA +  H+  V +L++ +     R    H  + +D +    L 
Sbjct: 152 NGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALL 211

Query: 459 FKQDHSLETR 468
            + DH+ + +
Sbjct: 212 LQNDHNADVQ 221


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  148 bits (374), Expect = 1e-35
 Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA+S NLD         V+IN  N      LH A    H+  V  LL  +  ++  
Sbjct: 48  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 107

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+AA +G  EV+  LV  GA+  A++Q G + L+ A Q NH+ +V++L++  
Sbjct: 108 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 165

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
           +  + N   E G  P  +A ++GH  ++  L    ++   K K++   L  AA    +  
Sbjct: 166 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 217

Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
               AA+ ++   +P     T    L                          Q G T LH
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277

Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
           +A++ G+   V++LL +   I    +  ++ L  A RNGH  +   LL     +  K + 
Sbjct: 278 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337

Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
             SP+H+    +H+  V  LL    +ID +     TPLHVAA  G+  + + LL  G   
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 397

Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
            +    G T L +A + NH  V+ +L+K
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLK 425



 Score =  135 bits (340), Expect = 1e-31
 Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N++ +ME L +   +I+ V     T LH A    HL  V  L
Sbjct: 397 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 456

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L+  A  +V++    T +H+AA +G  EV   L++  A   AK +D  + LH A +  H 
Sbjct: 457 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            +V+ L+++    + N     G  P  +AA  GHVE +  L       +   K  ++ L 
Sbjct: 517 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 574

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
            AA    K  +  +A L +E    P      G++   V+            L +GG+   
Sbjct: 575 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 630

Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
                 T LH+AAK       + LL      N  +   ++ L +A + GHA +V  LLS+
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 690

Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
             + +   +   +PLHLV    H+ V + L+     +D   +   TPLHVA+  GN++LV
Sbjct: 691 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 750

Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + LL+   D+ A  K G + L  A++  H+ +V +L+K
Sbjct: 751 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 788



 Score =  132 bits (333), Expect = 7e-31
 Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   NL++ + L  +  ++N       T LH A  R ++  V  LL   A+++   K  
Sbjct: 246 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 305

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
           LT +H AA +G + +  +L+  GA  +AK ++G+S +H A Q +H+  V  L+Q D  + 
Sbjct: 306 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
           D+         P  +AA  GH  + + L    L    K   +    +T      K +   
Sbjct: 366 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 418

Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
           +  L ++      TG S  +V+  + G T LH+A+  GH P V+ LL +    N  N   
Sbjct: 419 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470

Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            + L +A R GH  +  +LL     ++ K +  ++PLH      H  +V  LL    + +
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           +      TPLH+AA  G+VE V  LL+       + K+G T L VA++     V  +L++
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590

Query: 434 AERY 437
            + +
Sbjct: 591 RDAH 594



 Score =  132 bits (333), Expect = 7e-31
 Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E     AA++ + ++ + L + K  +N     ++T LH A    H + V  LL++ A  +
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 530

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           +A   G T +H+AA  G +E +L L++  A Q    + G + LH A +   VR+ E L++
Sbjct: 531 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590

Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
            D H    N   + G  P  +A    ++++++ L         +     S  W    T +
Sbjct: 591 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 639

Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
             +               G   +  SV     G T LHLAA+ GH+  V +LL++  + N
Sbjct: 640 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 695

Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
             N+  ++ L +  + GH  + + L+   V +        +PLH+     +I +V  LL 
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755

Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
            Q D++   +   +PLH AA +G+ ++V  LLK G     V   G T LA+A R  +  V
Sbjct: 756 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 815

Query: 428 VGML 431
             +L
Sbjct: 816 TDVL 819



 Score =  125 bits (315), Expect = 9e-29
 Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+ ++LD +  L +    I+ +   + T LH A    H      LL   A+ +    +G
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 404

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+A     + VM +L+K GA   A  + G++ LH A+   H+ IV+ L+Q      
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 462

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
            N  + K   P  +AA  GH E+ + L       + K K   + L  AA    +    ++
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 518

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
             L +E   +P    +         G+T LH+AA+ GH   V  LL +      M +   
Sbjct: 519 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 570

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
           + L +A + G   +   LL    D H     K   +PLH+ V +N++ +V  LL      
Sbjct: 571 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 628

Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
                   TPLH+AA +  VE+  +LL+ G    A   QG T L +A++  H+ +V +L+
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688

Query: 433 KAE 435
             +
Sbjct: 689 SKQ 691



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 45/151 (29%), Positives = 77/151 (50%)

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T+   AA+ G+       L    DIN  N+  ++ L +A++ GH  +V  LL + + L  
Sbjct: 47  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
             +   + LH+  +     VV  L++   +++  +QK  TPL++AA   ++E+V+ LL+ 
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           G +     + G T LAVA +  H  VV  LI
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLI 197


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  148 bits (374), Expect = 1e-35
 Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA+S NLD         V+IN  N      LH A    H+  V  LL  +  ++  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+AA +G  EV+  LV  GA+  A++Q G + L+ A Q NH+ +V++L++  
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
           +  + N   E G  P  +A ++GH  ++  L    ++   K K++   L  AA    +  
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184

Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
               AA+ ++   +P     T    L                          Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
           +A++ G+   V++LL +   I    +  ++ L  A RNGH  +   LL     +  K + 
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
             SP+H+    +H+  V  LL    +ID +     TPLHVAA  G+  + + LL  G   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
            +    G T L +A + NH  V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  135 bits (340), Expect = 1e-31
 Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N++ +ME L +   +I+ V     T LH A    HL  V  L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L+  A  +V++    T +H+AA +G  EV   L++  A   AK +D  + LH A +  H 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            +V+ L+++    + N     G  P  +AA  GHVE +  L       +   K  ++ L 
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
            AA    K  +  +A L +E    P      G++   V+            L +GG+   
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
                 T LH+AAK       + LL      N  +   ++ L +A + GHA +V  LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657

Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
             + +   +   +PLHLV    H+ V + L+     +D   +   TPLHVA+  GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717

Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + LL+   D+ A  K G + L  A++  H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  132 bits (333), Expect = 7e-31
 Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   NL++ + L  +  ++N       T LH A  R ++  V  LL   A+++   K  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
           LT +H AA +G + +  +L+  GA  +AK ++G+S +H A Q +H+  V  L+Q D  + 
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
           D+         P  +AA  GH  + + L    L    K   +    +T      K +   
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
           +  L ++      TG S  +V+  + G T LH+A+  GH P V+ LL +    N  N   
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            + L +A R GH  +  +LL     ++ K +  ++PLH      H  +V  LL    + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           +      TPLH+AA  G+VE V  LL+       + K+G T L VA++     V  +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 434 AERY 437
            + +
Sbjct: 558 RDAH 561



 Score =  132 bits (333), Expect = 7e-31
 Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E     AA++ + ++ + L + K  +N     ++T LH A    H + V  LL++ A  +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           +A   G T +H+AA  G +E +L L++  A Q    + G + LH A +   VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
            D H    N   + G  P  +A    ++++++ L         +     S  W    T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606

Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
             +               G   +  SV     G T LHLAA+ GH+  V +LL++  + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
             N+  ++ L +  + GH  + + L+   V +        +PLH+     +I +V  LL 
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
            Q D++   +   +PLH AA +G+ ++V  LLK G     V   G T LA+A R  +  V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 428 VGML 431
             +L
Sbjct: 783 TDVL 786



 Score =  125 bits (315), Expect = 9e-29
 Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+ ++LD +  L +    I+ +   + T LH A    H      LL   A+ +    +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+A     + VM +L+K GA   A  + G++ LH A+   H+ IV+ L+Q      
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
            N  + K   P  +AA  GH E+ + L       + K K   + L  AA    +    ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
             L +E   +P    +         G+T LH+AA+ GH   V  LL +      M +   
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
           + L +A + G   +   LL    D H     K   +PLH+ V +N++ +V  LL      
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
                   TPLH+AA +  VE+  +LL+ G    A   QG T L +A++  H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 433 KAE 435
             +
Sbjct: 656 SKQ 658



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 45/151 (29%), Positives = 77/151 (50%)

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T+   AA+ G+       L    DIN  N+  ++ L +A++ GH  +V  LL + + L  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
             +   + LH+  +     VV  L++   +++  +QK  TPL++AA   ++E+V+ LL+ 
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           G +     + G T LAVA +  H  VV  LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  148 bits (374), Expect = 1e-35
 Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA+S NLD         V+IN  N      LH A    H+  V  LL  +  ++  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+AA +G  EV+  LV  GA+  A++Q G + L+ A Q NH+ +V++L++  
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
           +  + N   E G  P  +A ++GH  ++  L    ++   K K++   L  AA    +  
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184

Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
               AA+ ++   +P     T    L                          Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
           +A++ G+   V++LL +   I    +  ++ L  A RNGH  +   LL     +  K + 
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
             SP+H+    +H+  V  LL    +ID +     TPLHVAA  G+  + + LL  G   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
            +    G T L +A + NH  V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  135 bits (340), Expect = 1e-31
 Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N++ +ME L +   +I+ V     T LH A    HL  V  L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L+  A  +V++    T +H+AA +G  EV   L++  A   AK +D  + LH A +  H 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            +V+ L+++    + N     G  P  +AA  GHVE +  L       +   K  ++ L 
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
            AA    K  +  +A L +E    P      G++   V+            L +GG+   
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
                 T LH+AAK       + LL      N  +   ++ L +A + GHA +V  LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657

Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
             + +   +   +PLHLV    H+ V + L+     +D   +   TPLHVA+  GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717

Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + LL+   D+ A  K G + L  A++  H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  132 bits (333), Expect = 7e-31
 Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   NL++ + L  +  ++N       T LH A  R ++  V  LL   A+++   K  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
           LT +H AA +G + +  +L+  GA  +AK ++G+S +H A Q +H+  V  L+Q D  + 
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
           D+         P  +AA  GH  + + L    L    K   +    +T      K +   
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
           +  L ++      TG S  +V+  + G T LH+A+  GH P V+ LL +    N  N   
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            + L +A R GH  +  +LL     ++ K +  ++PLH      H  +V  LL    + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           +      TPLH+AA  G+VE V  LL+       + K+G T L VA++     V  +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 434 AERY 437
            + +
Sbjct: 558 RDAH 561



 Score =  132 bits (333), Expect = 7e-31
 Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E     AA++ + ++ + L + K  +N     ++T LH A    H + V  LL++ A  +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           +A   G T +H+AA  G +E +L L++  A Q    + G + LH A +   VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
            D H    N   + G  P  +A    ++++++ L         +     S  W    T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606

Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
             +               G   +  SV     G T LHLAA+ GH+  V +LL++  + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
             N+  ++ L +  + GH  + + L+   V +        +PLH+     +I +V  LL 
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
            Q D++   +   +PLH AA +G+ ++V  LLK G     V   G T LA+A R  +  V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 428 VGML 431
             +L
Sbjct: 783 TDVL 786



 Score =  125 bits (315), Expect = 9e-29
 Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+ ++LD +  L +    I+ +   + T LH A    H      LL   A+ +    +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+A     + VM +L+K GA   A  + G++ LH A+   H+ IV+ L+Q      
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
            N  + K   P  +AA  GH E+ + L       + K K   + L  AA    +    ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
             L +E   +P    +         G+T LH+AA+ GH   V  LL +      M +   
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
           + L +A + G   +   LL    D H     K   +PLH+ V +N++ +V  LL      
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
                   TPLH+AA +  VE+  +LL+ G    A   QG T L +A++  H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 433 KAE 435
             +
Sbjct: 656 SKQ 658



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 45/151 (29%), Positives = 77/151 (50%)

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T+   AA+ G+       L    DIN  N+  ++ L +A++ GH  +V  LL + + L  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
             +   + LH+  +     VV  L++   +++  +QK  TPL++AA   ++E+V+ LL+ 
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           G +     + G T LAVA +  H  VV  LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  148 bits (374), Expect = 1e-35
 Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA+S NLD         V+IN  N      LH A    H+  V  LL  +  ++  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+AA +G  EV+  LV  GA+  A++Q G + L+ A Q NH+ +V++L++  
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
           +  + N   E G  P  +A ++GH  ++  L    ++   K K++   L  AA    +  
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184

Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
               AA+ ++   +P     T    L                          Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
           +A++ G+   V++LL +   I    +  ++ L  A RNGH  +   LL     +  K + 
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
             SP+H+    +H+  V  LL    +ID +     TPLHVAA  G+  + + LL  G   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
            +    G T L +A + NH  V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  135 bits (340), Expect = 1e-31
 Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N++ +ME L +   +I+ V     T LH A    HL  V  L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L+  A  +V++    T +H+AA +G  EV   L++  A   AK +D  + LH A +  H 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            +V+ L+++    + N     G  P  +AA  GHVE +  L       +   K  ++ L 
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
            AA    K  +  +A L +E    P      G++   V+            L +GG+   
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
                 T LH+AAK       + LL      N  +   ++ L +A + GHA +V  LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657

Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
             + +   +   +PLHLV    H+ V + L+     +D   +   TPLHVA+  GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717

Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + LL+   D+ A  K G + L  A++  H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  132 bits (333), Expect = 7e-31
 Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   NL++ + L  +  ++N       T LH A  R ++  V  LL   A+++   K  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
           LT +H AA +G + +  +L+  GA  +AK ++G+S +H A Q +H+  V  L+Q D  + 
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
           D+         P  +AA  GH  + + L    L    K   +    +T      K +   
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
           +  L ++      TG S  +V+  + G T LH+A+  GH P V+ LL +    N  N   
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            + L +A R GH  +  +LL     ++ K +  ++PLH      H  +V  LL    + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           +      TPLH+AA  G+VE V  LL+       + K+G T L VA++     V  +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 434 AERY 437
            + +
Sbjct: 558 RDAH 561



 Score =  132 bits (333), Expect = 7e-31
 Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E     AA++ + ++ + L + K  +N     ++T LH A    H + V  LL++ A  +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           +A   G T +H+AA  G +E +L L++  A Q    + G + LH A +   VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
            D H    N   + G  P  +A    ++++++ L         +     S  W    T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606

Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
             +               G   +  SV     G T LHLAA+ GH+  V +LL++  + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
             N+  ++ L +  + GH  + + L+   V +        +PLH+     +I +V  LL 
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
            Q D++   +   +PLH AA +G+ ++V  LLK G     V   G T LA+A R  +  V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 428 VGML 431
             +L
Sbjct: 783 TDVL 786



 Score =  125 bits (315), Expect = 9e-29
 Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+ ++LD +  L +    I+ +   + T LH A    H      LL   A+ +    +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+A     + VM +L+K GA   A  + G++ LH A+   H+ IV+ L+Q      
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
            N  + K   P  +AA  GH E+ + L       + K K   + L  AA    +    ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
             L +E   +P    +         G+T LH+AA+ GH   V  LL +      M +   
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
           + L +A + G   +   LL    D H     K   +PLH+ V +N++ +V  LL      
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
                   TPLH+AA +  VE+  +LL+ G    A   QG T L +A++  H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 433 KAE 435
             +
Sbjct: 656 SKQ 658



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 45/151 (29%), Positives = 77/151 (50%)

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T+   AA+ G+       L    DIN  N+  ++ L +A++ GH  +V  LL + + L  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
             +   + LH+  +     VV  L++   +++  +QK  TPL++AA   ++E+V+ LL+ 
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           G +     + G T LAVA +  H  VV  LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  148 bits (374), Expect = 1e-35
 Identities = 109/388 (28%), Positives = 174/388 (44%), Gaps = 35/388 (9%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           SF  AA+S NLD         V+IN  N      LH A    H+  V  LL  +  ++  
Sbjct: 15  SFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETT 74

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+AA +G  EV+  LV  GA+  A++Q G + L+ A Q NH+ +V++L++  
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE-- 132

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
           +  + N   E G  P  +A ++GH  ++  L    ++   K K++   L  AA    +  
Sbjct: 133 NGANQNVATEDGFTPLAVALQQGHENVVAHL----INYGTKGKVRLPALHIAA----RND 184

Query: 251 RNSIAALTIEGACSPGTGVSTSSVSL-------------------------LQGGNTALH 285
               AA+ ++   +P     T    L                          Q G T LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244

Query: 286 LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEP 345
           +A++ G+   V++LL +   I    +  ++ L  A RNGH  +   LL     +  K + 
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304

Query: 346 KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
             SP+H+    +H+  V  LL    +ID +     TPLHVAA  G+  + + LL  G   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIK 433
            +    G T L +A + NH  V+ +L+K
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLK 392



 Score =  135 bits (340), Expect = 1e-31
 Identities = 113/398 (28%), Positives = 182/398 (45%), Gaps = 37/398 (9%)

Query: 67  PNERSFQN------AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFL 120
           PN R+         A K N++ +ME L +   +I+ V     T LH A    HL  V  L
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNL 423

Query: 121 LKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
           L+  A  +V++    T +H+AA +G  EV   L++  A   AK +D  + LH A +  H 
Sbjct: 424 LQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483

Query: 181 RIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLW 240
            +V+ L+++    + N     G  P  +AA  GHVE +  L       +   K  ++ L 
Sbjct: 484 NMVKLLLENN--ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541

Query: 241 TAALTKMKTSRNSIAALTIEGACSPGT----GVSTSSVS------------LLQGGN--- 281
            AA    K  +  +A L +E    P      G++   V+            L +GG+   
Sbjct: 542 VAA----KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHS 597

Query: 282 ------TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
                 T LH+AAK       + LL      N  +   ++ L +A + GHA +V  LLS+
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSK 657

Query: 336 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELV 395
             + +   +   +PLHLV    H+ V + L+     +D   +   TPLHVA+  GN++LV
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717

Query: 396 ETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           + LL+   D+ A  K G + L  A++  H+ +V +L+K
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755



 Score =  132 bits (333), Expect = 7e-31
 Identities = 101/364 (27%), Positives = 169/364 (46%), Gaps = 16/364 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   NL++ + L  +  ++N       T LH A  R ++  V  LL   A+++   K  
Sbjct: 213 AAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDE 272

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLK 193
           LT +H AA +G + +  +L+  GA  +AK ++G+S +H A Q +H+  V  L+Q D  + 
Sbjct: 273 LTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
           D+         P  +AA  GH  + + L    L    K   +    +T      K +   
Sbjct: 333 DITLDH---LTPLHVAAHCGHHRVAKVL----LDKGAKPNSRALNGFTPLHIACKKNHVR 385

Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
           +  L ++      TG S  +V+  + G T LH+A+  GH P V+ LL +    N  N   
Sbjct: 386 VMELLLK------TGASIDAVT--ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437

Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            + L +A R GH  +  +LL     ++ K +  ++PLH      H  +V  LL    + +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           +      TPLH+AA  G+VE V  LL+       + K+G T L VA++     V  +L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 434 AERY 437
            + +
Sbjct: 558 RDAH 561



 Score =  132 bits (333), Expect = 7e-31
 Identities = 96/364 (26%), Positives = 165/364 (45%), Gaps = 16/364 (4%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E     AA++ + ++ + L + K  +N     ++T LH A    H + V  LL++ A  +
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN 497

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           +A   G T +H+AA  G +E +L L++  A Q    + G + LH A +   VR+ E L++
Sbjct: 498 LATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557

Query: 189 -DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
            D H    N   + G  P  +A    ++++++ L         +     S  W    T +
Sbjct: 558 RDAHP---NAAGKNGLTPLHVAVHHNNLDIVKLLL-------PRGGSPHSPAWNG-YTPL 606

Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
             +               G   +  SV     G T LHLAA+ GH+  V +LL++  + N
Sbjct: 607 HIAAKQNQVEVARSLLQYGGSANAESVQ----GVTPLHLAAQEGHAEMVALLLSKQANGN 662

Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
             N+  ++ L +  + GH  + + L+   V +        +PLH+     +I +V  LL 
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722

Query: 368 AQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 427
            Q D++   +   +PLH AA +G+ ++V  LLK G     V   G T LA+A R  +  V
Sbjct: 723 HQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISV 782

Query: 428 VGML 431
             +L
Sbjct: 783 TDVL 786



 Score =  125 bits (315), Expect = 9e-29
 Identities = 99/363 (27%), Positives = 162/363 (44%), Gaps = 18/363 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+ ++LD +  L +    I+ +   + T LH A    H      LL   A+ +    +G
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNG 371

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+A     + VM +L+K GA   A  + G++ LH A+   H+ IV+ L+Q      
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQ--RGAS 429

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
            N  + K   P  +AA  GH E+ + L       + K K   + L  AA    +    ++
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAA----RIGHTNM 485

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
             L +E   +P    +         G+T LH+AA+ GH   V  LL +      M +   
Sbjct: 486 VKLLLENNANPNLATTA--------GHTPLHIAAREGHVETVLALLEKEASQACMTKKGF 537

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKE--SPLHLVVINNHITVVNSLLSAQHDI 372
           + L +A + G   +   LL    D H     K   +PLH+ V +N++ +V  LL      
Sbjct: 538 TPLHVAAKYGKVRVAELLLER--DAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP 595

Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
                   TPLH+AA +  VE+  +LL+ G    A   QG T L +A++  H+ +V +L+
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655

Query: 433 KAE 435
             +
Sbjct: 656 SKQ 658



 Score = 73.2 bits (178), Expect = 7e-13
 Identities = 45/151 (29%), Positives = 77/151 (50%)

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T+   AA+ G+       L    DIN  N+  ++ L +A++ GH  +V  LL + + L  
Sbjct: 14  TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
             +   + LH+  +     VV  L++   +++  +QK  TPL++AA   ++E+V+ LL+ 
Sbjct: 74  TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           G +     + G T LAVA +  H  VV  LI
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLI 164


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  145 bits (366), Expect = 1e-34
 Identities = 108/384 (28%), Positives = 183/384 (47%), Gaps = 27/384 (7%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           S+  AA++ +L+      +  V+IN+ N     ALH A    H+  V  LL+ +A VD A
Sbjct: 44  SYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAA 103

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
            K G T +H+A+ +G  EV+ +LV  GA+  A++Q+G + L+ A Q NH+ +V++L+ + 
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAAL---TKM 247
             + L    E G  P  +A ++GH +++  L    L    K K++   L  AA    TK 
Sbjct: 164 ASQSL--ATEDGFTPLAVALQQGHDQVVSLL----LENDTKGKVRLPALHIAARKDDTKA 217

Query: 248 KT------------SRNSIAALTIE---GACSPGTGVSTSSVSL---LQGGNTALHLAAK 289
                         S++    L I    G  +  T +   + ++    +   T LH+A+K
Sbjct: 218 AALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASK 277

Query: 290 HGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESP 349
            G++  V++LL +   I+      ++ L    R+GH  +V  LL     +  K +   SP
Sbjct: 278 RGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSP 337

Query: 350 LHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVD 409
           LH+    +H+  V  LL     +D +     T LHVAA  G+ ++ + LL    +  A  
Sbjct: 338 LHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKA 397

Query: 410 KQGKTALAVASRSNHSLVVGMLIK 433
             G T L +A + N   V+ +L+K
Sbjct: 398 LNGFTPLHIACKKNRIKVMELLLK 421



 Score =  143 bits (360), Expect = 5e-34
 Identities = 108/415 (26%), Positives = 173/415 (41%), Gaps = 60/415 (14%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   +  + + L +KK N N       T LH A  +N +  ++ LLKH A +    + G
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD----- 189
           LT IH+AA+ G + ++  L+  GA     N  G +ALH A +S    +V YL+QD     
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493

Query: 190 ---------LHLK-----------------DLNQPDEKGRKPFLLAAERGHVEMIEKLTF 223
                    LH+                    N     G  P  L+A  GH ++   L  
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLD 553

Query: 224 LNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTG-------------VS 270
                S   K  ++ L  AA    K  +  +A L ++ + SP                  
Sbjct: 554 HGASLSITTKKGFTPLHVAA----KYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD 609

Query: 271 TSSVSLL------------QGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQ 318
              V+LL            + G T LH+AAK         LL    D N +    I+S+ 
Sbjct: 610 NQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVH 669

Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
           +A + GH  +V+ LL  N +++   +   +PLHL    + + V   L++    +D   + 
Sbjct: 670 LAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729

Query: 379 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             TPLHV    GN+++V  LL+    + A  K G T L  A++  H+ ++ +L++
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 784



 Score =  127 bits (319), Expect = 3e-29
 Identities = 124/512 (24%), Positives = 201/512 (39%), Gaps = 85/512 (16%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           A K N + +ME L +   +I  V     T +H A    H++ V  L+ H A  +  +  G
Sbjct: 407 ACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRG 466

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+AA SG  EV+  LV+ GA   AK +D  + LH + +     IV+ L+Q      
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG--AS 524

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
            N     G  P  L+A  GH ++   L       S   K  ++ L  AA    K  +  +
Sbjct: 525 PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAA----KYGKLEV 580

Query: 255 AALTIEGACSPGTG-------------VSTSSVSLL------------QGGNTALHLAAK 289
           A L ++ + SP                     V+LL            + G T LH+AAK
Sbjct: 581 ANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAK 640

Query: 290 HGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESP 349
                    LL    D N +    I+S+ +A + GH  +V+ LL  N +++   +   +P
Sbjct: 641 KNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP 700

Query: 350 LHL-----------VVINN----------------------HITVVNSLLSAQHDIDILN 376
           LHL           V++N                       +I +VN LL     ++   
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKT 760

Query: 377 QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAER 436
           +   TPLH AA +G+  ++  LL+       +   G TAL +A R  +  VV  L     
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL----- 815

Query: 437 YYAWREEHHESIRDPSTGFTLTFKQDHSLETRHIRTLLWDLAYHQL-KANEWQRLARSWN 495
                      I    T  T T  + H +        + D++  ++ KAN  + L+    
Sbjct: 816 ----------KIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEY 865

Query: 496 FTD-----DQIRAIEEQWSGNESFREHGHRAL 522
            +D     D +    +++ G +  +E G  +L
Sbjct: 866 ISDVEEGEDAMTGDTDKYLGPQDLKELGDDSL 897



 Score =  106 bits (265), Expect = 5e-23
 Identities = 81/359 (22%), Positives = 151/359 (42%), Gaps = 47/359 (13%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+ ++      L +   N +V +    T LH A    +++    LL   A VD   ++ 
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
           +T +H+A+  G+  ++ +L+  GA   AK +DG++ LH   +S H ++VE L+       
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD--RAAP 326

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           +    + G  P  +A +  H+  ++ L   N+                            
Sbjct: 327 ILSKTKNGLSPLHMATQGDHLNCVQLLLQHNV---------------------------- 358

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
                     P   V+   +       TALH+AA  GH    +VLL +  + N       
Sbjct: 359 ----------PVDDVTNDYL-------TALHVAAHCGHYKVAKVLLDKKANPNAKALNGF 401

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
           + L IA +     ++  LL     +    E   +P+H+     H+ +V+ L+      + 
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461

Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            N + +T LH+AA  G  E+V  L++ G  ++A  K  +T L +++R   + +V  L++
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 42/153 (27%), Positives = 77/153 (50%)

Query: 281 NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
           N +   AA+ GH       +    DIN  N+  +++L +A++ GH  +V+ LL    ++ 
Sbjct: 42  NASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVD 101

Query: 341 QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 400
              +   + LH+  +     VV  L++   +++  +Q   TPL++AA   ++E+V+ LL 
Sbjct: 102 AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLD 161

Query: 401 AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            G       + G T LAVA +  H  VV +L++
Sbjct: 162 NGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  144 bits (362), Expect = 3e-34
 Identities = 105/346 (30%), Positives = 164/346 (47%), Gaps = 13/346 (3%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA +  +   E L     N+NV +   RTALH A    H   V  LL   A ++  DK  
Sbjct: 114 AAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD 173

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
              IH AA+ G +EV+ +LV  GA+   K++   + LH A  S  + +V+YL+ DL + D
Sbjct: 174 RRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLL-DLGV-D 231

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           +N+P+  G  P  +A   G   ++ +L       ++K++  ++ L  AA +       + 
Sbjct: 232 MNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAAS-------TH 284

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
            AL +E     G  V+  S    + G T LH+ A HG     Q ++     I+  ++   
Sbjct: 285 GALCLELLVGNGADVNMKS----KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGN 340

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
           + L IA R GH  L+N L++   D  ++      PLHL  ++        LLS+  DID 
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400

Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
            +   +T LH AA  GN+E +  LL  G D    DK G++ L  A+
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAA 446



 Score =  134 bits (338), Expect = 2e-31
 Identities = 109/383 (28%), Positives = 176/383 (45%), Gaps = 17/383 (4%)

Query: 64  LLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKH 123
           L L ++ S   A  + + D +  L  KK ++N  +N  RT LH A        ++ L+  
Sbjct: 4   LKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILS 63

Query: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
            ARV+  D   LT +H A  S S E + +L+K  AD  A++++  + LH A  +  V+  
Sbjct: 64  GARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCA 123

Query: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTL-WTA 242
           E L+    L ++N  D  GR     AA  GH EM++ L     + +  DK     + W A
Sbjct: 124 EALVP--LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAA 181

Query: 243 ALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQ 302
            +  ++          ++   S G  V+       +   T LH AA  G    V+ LL  
Sbjct: 182 YMGHIE---------VVKLLVSHGAEVTCKD----KKSYTPLHAAASSGMISVVKYLLDL 228

Query: 303 WQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVV 362
             D+NE N    + L +A  NG   +VN L+     ++QK E   +PLH    + H  + 
Sbjct: 229 GVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC 288

Query: 363 NSLLSAQ-HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASR 421
             LL     D+++ ++  +TPLH+ A  G     +T++++G  +   DK G T L +A+R
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAAR 348

Query: 422 SNHSLVVGMLIKAERYYAWREEH 444
             H L++  LI +    A R  H
Sbjct: 349 YGHELLINTLITSGADTAKRGIH 371



 Score =  125 bits (314), Expect = 1e-28
 Identities = 96/352 (27%), Positives = 167/352 (47%), Gaps = 15/352 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   + +++E L      +N  ++   T LH AV      AV  LLKH A V+  DK+ 
Sbjct: 48  AAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNW 107

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+AA + +++    LV   ++    ++ G +ALH A  S H  +V+ L+      +
Sbjct: 108 QTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLS--RGAN 165

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           +N  D+K R+    AA  GH+E+++ L       + KDK  ++ L  AA + M +    +
Sbjct: 166 INAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYL 225

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
             L          GV  +  +    GNT LH+A  +G    V  L+     +N+ NE   
Sbjct: 226 LDL----------GVDMNEPNAY--GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGF 273

Query: 315 SSLQIATRNGHASL-VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
           + L  A  + H +L +  L+    D++ K +  ++PLH+  ++   +   +++ +   ID
Sbjct: 274 TPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID 333

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHS 425
             ++   TPLH+AA  G+  L+ TL+ +G D       G   L +A+ S  S
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFS 385



 Score =  108 bits (271), Expect = 1e-23
 Identities = 107/389 (27%), Positives = 172/389 (44%), Gaps = 33/389 (8%)

Query: 57  TAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSA 116
           +A  GH L L      Q  A    LD++ +     +  +  N    + LH A    H  A
Sbjct: 512 SAAYGHRLCL------QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQA 565

Query: 117 VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQD-GMSALHFAT 175
           ++ L++    +DV +  G T + LAA+ G +E + +L+  GA    K+     + +H A 
Sbjct: 566 LEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAA 625

Query: 176 QSNHVRIVEYLIQDLHLKD-LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKI 234
            + H   +  LI +   ++ ++  D  G+ P +L+   GH + +  L     +   KDK 
Sbjct: 626 TNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKW 685

Query: 235 QWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG--GNTALHLAAKHGH 292
             + L   A+T  +     + AL   GA             LL+   G T +HL+A  GH
Sbjct: 686 GRTALHRGAVTGHE---ECVDALLQHGA-----------KCLLRDSRGRTPIHLSAACGH 731

Query: 293 SPAVQVLL--AQWQDINEMNELN--ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKE- 347
              +  LL  A   D N     N   ++L  A  NGH + V  LL + V   QK E    
Sbjct: 732 IGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV--FQKTEGNAF 789

Query: 348 SPLHLVVINNHITVVNSLLSA--QHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 405
           SPLH  VIN++      L+       ++  + K +TPLH AA   +VE ++ LL     +
Sbjct: 790 SPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQV 849

Query: 406 KAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            +VD  GKT L +A+ +  +  V ML+ +
Sbjct: 850 NSVDSTGKTPLMMAAENGQTNTVEMLVSS 878



 Score =  105 bits (262), Expect = 1e-22
 Identities = 108/398 (27%), Positives = 179/398 (44%), Gaps = 39/398 (9%)

Query: 56  DTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLS 115
           DTA  G   + P       AA S   D   KL     +I+  ++  RT LH A    +L 
Sbjct: 364 DTAKRGIHGMFP----LHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419

Query: 116 AVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFA- 174
            ++ LL   A  +  DK G + +H AA + + + +  LV +GA     ++ G + LH+A 
Sbjct: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479

Query: 175 TQSNHVRIVEYLIQDLHLKDLNQP--DEKGRKPFLLAAERGH---VEMIEKLTFLN--LH 227
           T     + +EYL+++    D N    D++G      +A  GH   +++I   T L+  + 
Sbjct: 480 TSDTDGKCLEYLLRN----DANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLME 535

Query: 228 TSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQ------GGN 281
           TS  D +  S            +R +I+ L +         +     SLL        G 
Sbjct: 536 TSGTDMLSDSD-----------NRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR 584

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNE-LNISSLQIATRNGHASLVNFLLSENVDLH 340
           T L LAA  GH   V VL+ Q   I   +  L  + +  A  NGH+  +  L+  N +  
Sbjct: 585 TPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIG-NAEPQ 643

Query: 341 QKVEPKE----SPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVE 396
             V+ ++    +PL L V+N H   V SLL+   ++D  ++  +T LH  A  G+ E V+
Sbjct: 644 NAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVD 703

Query: 397 TLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            LL+ G      D +G+T + +++   H  V+G L+++
Sbjct: 704 ALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQS 741



 Score =  102 bits (255), Expect = 8e-22
 Identities = 96/343 (27%), Positives = 146/343 (42%), Gaps = 38/343 (11%)

Query: 94  INVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLML 153
           +++ +   +T L  +V   H   V  LL   A VD  DK G T +H  A +G  E +  L
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705

Query: 154 VKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLN--QPDEKGRKPFLLAAE 211
           ++ GA    ++  G + +H +    H+ ++  L+Q     D N    D  G      A  
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACY 765

Query: 212 RGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI------EGACSP 265
            GH   +E L        E++  Q            KT  N+ + L        EGA   
Sbjct: 766 NGHETCVELLL-------EQEVFQ------------KTEGNAFSPLHCAVINDNEGAAE- 805

Query: 266 GTGVSTSSVSLLQG----GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIAT 321
              + T   S++      G T LH AA   H   +Q+LL+    +N ++    + L +A 
Sbjct: 806 -MLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAA 864

Query: 322 RNGHASLVNFLLSE-NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ- 379
            NG  + V  L+S  + +L  +   K + LHL     H T    +L    D +++N    
Sbjct: 865 ENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNA 924

Query: 380 --QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKT-ALAVA 419
             QTPLHVAA  G   +V+ LL  G  + AVD+ G T ALA A
Sbjct: 925 ALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACA 967



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 80/301 (26%), Positives = 122/301 (40%), Gaps = 50/301 (16%)

Query: 78  SNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTV 137
           + + D +  L  K  N++  +   RTALH      H   VD LL+H A+  + D  G T 
Sbjct: 663 NGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTP 722

Query: 138 IHLAAWSGSLEVMLMLVKAGADQRAK----NQDGMSALHFATQSNHVRIVEYLIQD---- 189
           IHL+A  G + V+  L+++ A   A     +  G +ALH+A  + H   VE L++     
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782

Query: 190 ----------------------------LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
                                       L    +N  D KGR P   AA   HVE ++ L
Sbjct: 783 KTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842

Query: 222 TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN 281
              N   +  D    ST  T  +   +  + +   + +  A +  T    S        N
Sbjct: 843 LSHNAQVNSVD----STGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSK-------N 891

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNI---SSLQIATRNGHASLVNFLLSENVD 338
           TALHLA   GH  +  ++L +  D N +N  N    + L +A RNG   +V  LL +   
Sbjct: 892 TALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGAS 951

Query: 339 L 339
           +
Sbjct: 952 V 952


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  138 bits (347), Expect = 2e-32
 Identities = 107/364 (29%), Positives = 175/364 (48%), Gaps = 31/364 (8%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA +      E L     ++NV +   R+ALH AV   HL  V+ LL   A ++V DK  
Sbjct: 114 AAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKE 173

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
              +H AA+ G LEV+ +LV  GAD   K++ G   LH A  S  + +V+YL++     +
Sbjct: 174 RQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLR--MGAE 231

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           +++P+  G     +A   G   +  +L     + ++ +   ++ L  AA+       ++ 
Sbjct: 232 IDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAV-------STN 284

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
            AL +E   + G  V+  S    + G + LH+AA HG     Q+L+    +I+  ++   
Sbjct: 285 GALCLELLVNNGADVNYQS----KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGN 340

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVI-------------NNHITV 361
           + L +A R GH  L++ L++   D  ++      PLHL V+                 ++
Sbjct: 341 TPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSI 400

Query: 362 VNSL-----LSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTAL 416
           V+SL     LSA  DI+  +   +T LH AA  GNVE +  LL +G DL+  DK G+T L
Sbjct: 401 VSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPL 460

Query: 417 AVAS 420
             A+
Sbjct: 461 HYAA 464



 Score =  116 bits (291), Expect = 5e-26
 Identities = 97/371 (26%), Positives = 169/371 (45%), Gaps = 17/371 (4%)

Query: 64  LLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKH 123
           L + ++     A  S +++ +  L  +K NINV++   RT LH A     +  +  LL  
Sbjct: 4   LSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMS 63

Query: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
            A V+  D   LT +H AA S + +V+ +L+   AD  A+++   + LH A  +   +  
Sbjct: 64  GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 123

Query: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTL-WTA 242
           E L     L  LN  D  GR     A   GH+E +  L       +  DK +   L W A
Sbjct: 124 EALAP--LLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAA 181

Query: 243 ALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQ 302
            L  ++  +  +A          G  +        + G   LH AA  G    V+ LL  
Sbjct: 182 FLGHLEVLKLLVAR---------GADLGCKD----RKGYGLLHTAAASGQIEVVKYLLRM 228

Query: 303 WQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVIN-NHITV 361
             +I+E N    ++L IA   G  ++   L++   +++Q  +   +PLH+  ++ N    
Sbjct: 229 GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALC 288

Query: 362 VNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASR 421
           +  L++   D++  +++ ++PLH+AA  G     + L++ G ++   DK G T L VA+R
Sbjct: 289 LELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAAR 348

Query: 422 SNHSLVVGMLI 432
             H L++  L+
Sbjct: 349 YGHELLISTLM 359



 Score = 99.0 bits (245), Expect = 1e-20
 Identities = 94/356 (26%), Positives = 153/356 (42%), Gaps = 23/356 (6%)

Query: 75   AAKSNNLDLMEKLFEKKVNINVVNNMN---RTALHFAVGRNHLSAVDFLLKHKARVDVAD 131
            AA S + D +  L +     ++ + M+   +T L  A+   H+  V  LL+  +  D AD
Sbjct: 659  AAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAAD 718

Query: 132  KHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
              G T +H  A +G  + +  L+   A    ++  G + +H A+   H  ++  L+Q   
Sbjct: 719  LRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAAL 778

Query: 192  LKDLNQP--DEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM-K 248
              D      D  G  P   A+  GH + +E L   +   S  +   ++ L  A +     
Sbjct: 779  STDPLDAGVDYSGYSPMHWASYTGHEDCLE-LLLEHSPFSYLEGNPFTPLHCAVINNQDS 837

Query: 249  TSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINE 308
            T+   + AL        G  +  S  +    G T LH AA   +   +++LL    ++N 
Sbjct: 838  TTEMLLGAL--------GAKIVNSRDAK---GRTPLHAAAFADNVSGLRMLLQHQAEVNA 886

Query: 309  MNELNISSLQIATRNGHASLVNFLLSEN-VDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
             +    ++L  A  NG  + V FLL     DL    E K + LHL     H      +L+
Sbjct: 887  TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILA 946

Query: 368  AQHDIDILNQKQ---QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKT-ALAVA 419
               D+ ++N      Q PLH+AA  G   +V+ LL  G  + AVD++G T ALA A
Sbjct: 947  ETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACA 1002



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 99/368 (26%), Positives = 152/368 (41%), Gaps = 23/368 (6%)

Query: 75  AAKSNNLDLMEKLFEKKVNI--NVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADK 132
           AA   N   +E L E   N   +V + +  + LH A    H  A+  L +    +DV D 
Sbjct: 557 AAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDH 616

Query: 133 HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGM-SALHFATQSNHVRIVEYLIQDLH 191
            G T + LA   GS E + +L   GA    K +    + LH A  S H   +  LI    
Sbjct: 617 KGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGE 676

Query: 192 LKDLNQP-DEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
             D+    D  G+ P +LA   GHV+ +  L          D    + L   A+T  +  
Sbjct: 677 RADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE-- 734

Query: 251 RNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMN 310
            + +AAL    A                 G T +HLA+  GH+  ++ LL      + ++
Sbjct: 735 -DCLAALLDHDAFVLCRDFK---------GRTPIHLASACGHTAVLRTLLQAALSTDPLD 784

Query: 311 E----LNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLL 366
                   S +  A+  GH   +  LL  +   + +  P  +PLH  VINN  +    LL
Sbjct: 785 AGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-TPLHCAVINNQDSTTEMLL 843

Query: 367 SA--QHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNH 424
            A     ++  + K +TPLH AA   NV  +  LL+   ++ A D  G+TAL  A+ +  
Sbjct: 844 GALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQ 903

Query: 425 SLVVGMLI 432
           +  V  L+
Sbjct: 904 TAAVEFLL 911



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 92/336 (27%), Positives = 153/336 (45%), Gaps = 21/336 (6%)

Query: 85  EKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWS 144
           E +     +IN  +N+ RT LH A    ++  ++ LL   A +   DK G T +H AA +
Sbjct: 407 EHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466

Query: 145 GSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRK 204
           GS +  + LV AGA     +  G S LH+A  S+  R  E      H  + ++P ++ R+
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRR 526

Query: 205 PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACS 264
                  +     +E L       S +D+  ++ +  AA       +N    L +   C 
Sbjct: 527 -------KEAFFCLEFLLDNGADPSLRDRQGYTAVHYAA--AYGNRQNLELLLEMSFNCL 577

Query: 265 PGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNG 324
                ST  VS        LHLAA +GH  A++ L     +++  +    ++L +AT  G
Sbjct: 578 EDV-ESTIPVS-------PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERG 629

Query: 325 HASLVNFLLSENVD-LHQKVEPKESPLHLVVINNHITVVNSLLSA--QHDI-DILNQKQQ 380
               V  L +     L ++ + K +PLH    + H   ++ L+ +  + DI D+++   Q
Sbjct: 630 STECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQ 689

Query: 381 TPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTAL 416
           TPL +A   G+V+ V  LL+ G    A D +G+TAL
Sbjct: 690 TPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTAL 725



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 64/242 (26%), Positives = 107/242 (44%), Gaps = 12/242 (4%)

Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
           +++N  D++ R P   AA  G V +++ L     + + KD     TLW   L +   SRN
Sbjct: 32  ENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKD-----TLWLTPLHRAAASRN 86

Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
                 + G     +    +   L Q   T LH+AA +  +   + L      +N  +  
Sbjct: 87  E----KVLGLLLAHSADVNARDKLWQ---TPLHVAAANRATKCAEALAPLLSSLNVADRS 139

Query: 313 NISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDI 372
             S+L  A  +GH   VN LL++   L+   + +  PLH      H+ V+  L++   D+
Sbjct: 140 GRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADL 199

Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
              ++K    LH AA  G +E+V+ LL+ G ++   +  G TAL +A       V   L+
Sbjct: 200 GCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELV 259

Query: 433 KA 434
            A
Sbjct: 260 NA 261



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 95/424 (22%), Positives = 171/424 (40%), Gaps = 57/424 (13%)

Query: 52  LGEEDTAVAGHELLLPNERS---FQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFA 108
           L  E    AG ++  P+         AA   N++ +  L     ++   +   RT LH+A
Sbjct: 404 LSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463

Query: 109 VGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLE-------------------- 148
                      L+   A V+ AD  G + +H AA S +                      
Sbjct: 464 AANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKE 523

Query: 149 --------VMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLH--LKDLNQP 198
                    +  L+  GAD   +++ G +A+H+A    + + +E L++     L+D+   
Sbjct: 524 SRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVEST 583

Query: 199 DEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALT 258
                 P  LAA  GH E ++ L    ++   +D    + L+ A     + S   +  LT
Sbjct: 584 IPVS--PLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLAT---ERGSTECVEVLT 638

Query: 259 IEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQ--DINE-MNELNIS 315
             GA        ++ +   +   T LH AA  GH+ ++ +L+   +  DI + M+    +
Sbjct: 639 AHGA--------SALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQT 690

Query: 316 SLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDIL 375
            L +A  NGH   V+ LL +            + LH   +      + +LL   HD  +L
Sbjct: 691 PLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLD--HDAFVL 748

Query: 376 NQ--KQQTPLHVAADRGNVELVETLLKAGCDL----KAVDKQGKTALAVASRSNHSLVVG 429
            +  K +TP+H+A+  G+  ++ TLL+A          VD  G + +  AS + H   + 
Sbjct: 749 CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLE 808

Query: 430 MLIK 433
           +L++
Sbjct: 809 LLLE 812



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 42/155 (27%), Positives = 75/155 (48%), Gaps = 9/155 (5%)

Query: 74  NAAKSNNLDLMEKLFEKKVNINVVNNMN---RTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           + A  NN D   ++    +   +VN+ +   RT LH A   +++S +  LL+H+A V+  
Sbjct: 828 HCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNAT 887

Query: 131 DKHGLTVIHLAAWSG-SLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLI-- 187
           D  G T +  AA +G +  V  +L +  AD    +++  +ALH A    H +    ++  
Sbjct: 888 DHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAE 947

Query: 188 -QDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
            QDL L  +N  +   + P  +AA  G   +++ L
Sbjct: 948 TQDLGL--INATNSALQMPLHIAARNGLASVVQAL 980


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  135 bits (340), Expect = 1e-31
 Identities = 103/347 (29%), Positives = 167/347 (48%), Gaps = 17/347 (4%)

Query: 87  LFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGS 146
           L  K  ++N +++  RT LH A        ++ L+   ARV+  D   LT +H A  S S
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 147 LEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPF 206
            E + +L+K  AD  A++++  + LH A  +  V+  E +I    L  +N  D  GR   
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIP--LLSSVNVSDRGGRTAL 119

Query: 207 LLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTL-WTAALTKMKTSRNSIAALTIEGACSP 265
             AA  GHVEM+  L     + +  DK     L W A +  +      + AL I    + 
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHL-----DVVALLI----NH 170

Query: 266 GTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGH 325
           G  V+       + G T LH AA +G    V+ LL    +I+E+N    ++L IA  NG 
Sbjct: 171 GAEVTCKD----KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226

Query: 326 ASLVNFLLSENVDLHQKVEPKESPLHLVVINNH-ITVVNSLLSAQHDIDILNQKQQTPLH 384
            ++VN L+    +++Q      +PLH    + H    +  L++   D++I ++  ++PLH
Sbjct: 227 DAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLH 286

Query: 385 VAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
           + A  G     +TL++ G ++  VDK G T L VA+R  H L++  L
Sbjct: 287 MTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333



 Score =  135 bits (339), Expect = 1e-31
 Identities = 102/362 (28%), Positives = 158/362 (43%), Gaps = 46/362 (12%)

Query: 71  SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
           +  +AA + +++++  L  K  NIN  +  +R ALH+A    HL  V  L+ H A V   
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177

Query: 131 DKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL 190
           DK G T +H AA +G + V+  L+  G +    N  G +ALH A  +    +V  LI   
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID-- 235

Query: 191 HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTS 250
           +  ++NQP+  G  P   AA   H                                    
Sbjct: 236 YGANVNQPNNNGFTPLHFAAASTH------------------------------------ 259

Query: 251 RNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMN 310
                AL +E   + G  V+  S    + G + LH+ A HG     Q L+    +I+ ++
Sbjct: 260 ----GALCLELLVNNGADVNIQS----KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVD 311

Query: 311 ELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQH 370
           +   + L +A R GH  L+N L +   D  +       PLHL  +N H      LLS+  
Sbjct: 312 KDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGF 371

Query: 371 DIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGM 430
           +ID  ++  +T LH AA  GNVE ++ L  +G D    DK G+T L  A+ + H   +  
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431

Query: 431 LI 432
           L+
Sbjct: 432 LV 433



 Score =  130 bits (326), Expect = 5e-30
 Identities = 95/352 (26%), Positives = 167/352 (47%), Gaps = 15/352 (4%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA   + +++E L      +N  +NM  T LH AV      AV  L+KH A V+  DK+ 
Sbjct: 23  AAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNW 82

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H+AA + +++   +++   +     ++ G +ALH A  + HV +V  L+      +
Sbjct: 83  QTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLL--AKGAN 140

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           +N  D+K R+    AA  GH++++  L       + KDK  ++ L  AA          +
Sbjct: 141 INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHL 200

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
             L          GV    +++   GNTALH+A  +G    V  L+    ++N+ N    
Sbjct: 201 LNL----------GVEIDEINVY--GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGF 248

Query: 315 SSLQIATRNGHASL-VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
           + L  A  + H +L +  L++   D++ + +  +SPLH+  ++   T   +L+    +ID
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHS 425
            +++   TPLHVAA  G+  L+ TL  +G D           L +A+ + HS
Sbjct: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHS 360



 Score =  114 bits (286), Expect = 2e-25
 Identities = 108/393 (27%), Positives = 168/393 (42%), Gaps = 44/393 (11%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFA-----------VGRNHLSA------- 116
           AA + +   +E L     N+N  ++  RTALH+A           +G  H ++       
Sbjct: 420 AAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERAR 479

Query: 117 ----------VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQD 166
                     ++FLL++ A   + DK G   IH AA  G  + + +L++       ++  
Sbjct: 480 ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS 539

Query: 167 GM--SALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFL 224
           G   S LH A  + H + +E L+Q L   DL+  DEKGR    LAA +GH E +E L   
Sbjct: 540 GATKSPLHLAAYNGHHQALEVLLQSL--VDLDIRDEKGRTALDLAAFKGHTECVEALINP 597

Query: 225 NLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTAL 284
                 KD +   T   A++    T       L +E A +P   V          G T L
Sbjct: 598 GASIFVKDNVTKRTPLHASVINGHTL---CLRLLLEIADNP-EAVDVKDAK----GQTPL 649

Query: 285 HLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVE 344
            LA  +GH  AV +LL +  +++ ++ L  ++L      GH   V  LL + V +  K  
Sbjct: 650 MLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDS 709

Query: 345 PKESPLHLVVINNHITVVNSLLS---AQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
              +PLH      H T ++ LL    ++ D    + +  TPLH A   GN   +E LL+ 
Sbjct: 710 RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ 769

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            C  K +     T L  A  ++H     +L+ A
Sbjct: 770 KCFRKFIGNP-FTPLHCAIINDHGNCASLLLGA 801



 Score =  114 bits (285), Expect = 3e-25
 Identities = 103/364 (28%), Positives = 161/364 (44%), Gaps = 46/364 (12%)

Query: 105 LHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKN 164
           LH A    H      LL     +D  DK G T +H AA  G++E + +L  +GAD   K+
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD 410

Query: 165 QDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAA-------------- 210
           + G + LH+A  + H   +E L+      ++N+ D+ GR     AA              
Sbjct: 411 KCGRTPLHYAAANCHFHCIETLVTTG--ANVNETDDWGRTALHYAAASDMDRNKTILGNA 468

Query: 211 -------ERGHVEMIEK-----LTFL---NLHTSEKDKIQWSTLWTAALTKMKTSRNSIA 255
                  ER   E+ EK     L FL   + + S +DK  ++++  AA    +     + 
Sbjct: 469 HDNSEELERAR-ELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527

Query: 256 ALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNIS 315
             T  G     +G + S           LHLAA +GH  A++VLL    D++  +E   +
Sbjct: 528 ERTNSGFEESDSGATKSP----------LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRT 577

Query: 316 SLQIATRNGHASLVNFLLSENVDLHQKVE-PKESPLHLVVINNHITVVNSLLSAQHD--- 371
           +L +A   GH   V  L++    +  K    K +PLH  VIN H   +  LL    +   
Sbjct: 578 ALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEA 637

Query: 372 IDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
           +D+ + K QTPL +A   G+++ V  LL+   ++  VD  G TAL     + H   V ML
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697

Query: 432 IKAE 435
           ++ E
Sbjct: 698 LEQE 701



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 103/414 (24%), Positives = 167/414 (40%), Gaps = 75/414 (18%)

Query: 83  LMEKLFEKKVNINVVNNMNRTALHFAVGRNHLS-AVDFLLKHKARVDVADKHGLTVIHLA 141
           ++ +L +   N+N  NN   T LHFA    H +  ++ L+ + A V++  K G + +H+ 
Sbjct: 229 VVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMT 288

Query: 142 AWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYL--------------I 187
           A  G       L++ G +    ++DG + LH A +  H  ++  L              +
Sbjct: 289 AVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSM 348

Query: 188 QDLHLKDLNQ-----------------PDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSE 230
             LHL  LN                  PD+ GR     AA  G+VE I+ L        +
Sbjct: 349 FPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHK 408

Query: 231 KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKH 290
           KDK   + L  AA         +     IE   + G  V+ +       G TALH AA  
Sbjct: 409 KDKCGRTPLHYAAA--------NCHFHCIETLVTTGANVNETD----DWGRTALHYAAAS 456

Query: 291 GHSPAVQVL---------LAQWQDINE-----------MNELNIS--------SLQIATR 322
                  +L         L + +++ E            N+ N S        S+  A  
Sbjct: 457 DMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAA 516

Query: 323 NGHASLVNFLLSENVDLHQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQ 380
            GH   +  LL       ++ +    +SPLHL   N H   +  LL +  D+DI ++K +
Sbjct: 517 YGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGR 576

Query: 381 TPLHVAADRGNVELVETLLKAGCDLKAVDKQGK-TALAVASRSNHSLVVGMLIK 433
           T L +AA +G+ E VE L+  G  +   D   K T L  +  + H+L + +L++
Sbjct: 577 TALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLE 630



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 80/302 (26%), Positives = 130/302 (43%), Gaps = 17/302 (5%)

Query: 81  LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHL 140
           L L+ ++ +    ++V +   +T L  AV   H+ AV  LL+ +A VD  D  G T +H 
Sbjct: 625 LRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHR 684

Query: 141 AAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ-DLHLKDLNQPD 199
              +G  E + ML++       K+  G + LH+A    H   +  L+Q  L  +D    D
Sbjct: 685 GIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKD 744

Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQW-STLWTAALTKMKTSRNSIAALT 258
            +G  P   A   G+   IE L        +K   ++    +T     +     + A+L 
Sbjct: 745 NQGYTPLHWACYNGNENCIEVLL------EQKCFRKFIGNPFTPLHCAIINDHGNCASLL 798

Query: 259 IEGACSPGTGVSTSSVSLLQG-GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSL 317
           + GA      + +S VS     G T L  AA   H   +Q+LL     +N ++    ++L
Sbjct: 799 L-GA------IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTAL 851

Query: 318 QIATRNGHASLVNFLL-SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILN 376
            +A  NG A  V+ L+ S   DL  K +   +PLHL     H      +L    D  ++N
Sbjct: 852 MMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911

Query: 377 QK 378
           +K
Sbjct: 912 EK 913



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 68/274 (24%), Positives = 106/274 (38%), Gaps = 46/274 (16%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           A    ++D +  L EK+ N++ V+ +  TALH  +   H   V  LL+ +  +   D  G
Sbjct: 652 AVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG 711

Query: 135 LTVIHLAAWSGS---LEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD-- 189
            T +H AA  G    L  +L +  +  D   K+  G + LH+A  + +   +E L++   
Sbjct: 712 RTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKC 771

Query: 190 -----------LHLKDLNQP-------------------DEKGRKPFLLAAERGHVEMIE 219
                      LH   +N                     D+KGR P   AA   HVE ++
Sbjct: 772 FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQ 831

Query: 220 KLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
            L   +   +  D    + L  AA        N  A        S    ++     L   
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMAA-------ENGQAGAVDILVNSAQADLTVKDKDL--- 881

Query: 280 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
            NT LHLA   GH     ++L + QD + +NE N
Sbjct: 882 -NTPLHLACSKGHEKCALLILDKIQDESLINEKN 914



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 35/135 (25%), Positives = 67/135 (49%)

Query: 298 VLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINN 357
           +L+ + +D+N ++    + L +A   G A ++  L+     ++ K     +PLH  V + 
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 358 HITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALA 417
               V  L+    D++  ++  QTPLHVAA    V+  E ++     +   D+ G+TAL 
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120

Query: 418 VASRSNHSLVVGMLI 432
            A+ + H  +V +L+
Sbjct: 121 HAALNGHVEMVNLLL 135


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  134 bits (337), Expect = 2e-31
 Identities = 96/364 (26%), Positives = 173/364 (47%), Gaps = 19/364 (5%)

Query: 75   AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAV-----GRNHLSAVDFLLKHKARVDV 129
            AA   + +++E L +    +N  +   RTAL  A       + H S V  L+   A VD 
Sbjct: 684  AAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743

Query: 130  ADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD 189
             DK G+T + +AA+ G ++V+ +L++ GAD    + +G + L  A    H  +V  L+  
Sbjct: 744  CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL-- 801

Query: 190  LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
                 ++  D +GR    +A+ +G+VE++  L    L  + +D   W+ L  AA      
Sbjct: 802  FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE---- 857

Query: 250  SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
                I    IE       G  T+ +     G     LA++ GH   VQ+LL    +I++ 
Sbjct: 858  GHRLICEALIE------QGARTNEID--NDGRIPFILASQEGHYDCVQILLENKSNIDQR 909

Query: 310  NELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQ 369
                 ++L++A   GH  +V  L S   D++ K       L+++ + N +T+    L   
Sbjct: 910  GYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENG 969

Query: 370  HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVG 429
             +++  + + +T LHV+  +G++E+V+ L+    D+ A D + ++AL  A+   H  VV 
Sbjct: 970  ANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQ 1029

Query: 430  MLIK 433
            +LI+
Sbjct: 1030 LLIE 1033



 Score =  132 bits (333), Expect = 7e-31
 Identities = 95/359 (26%), Positives = 167/359 (46%), Gaps = 14/359 (3%)

Query: 75   AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
            AA   ++D+++ L E   +++  +N  RT L  A    H S V+ LL   A VD  D  G
Sbjct: 755  AAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814

Query: 135  LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
             TV+ +A+  G++EV+  L+  G D+  ++  G + LH A    H  I E LI+      
Sbjct: 815  RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG--AR 872

Query: 195  LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
             N+ D  GR PF+LA++ GH + ++ L     +  ++     + L  AAL   +      
Sbjct: 873  TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRD----- 927

Query: 255  AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
                +E   S G  V+         G   L++ A        +  L    ++   +    
Sbjct: 928  ---IVELLFSHGADVNCKDAD----GRPTLYILALENQLTMAEYFLENGANVEASDAEGR 980

Query: 315  SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
            ++L ++   GH  +V  L++ + D++     K S L       H+ VV  L+     +D 
Sbjct: 981  TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040

Query: 375  LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
               +  T L +AA  G++++V+ LL+ G D    D+ G+TA+ VA+++ HS ++ +L K
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEK 1099



 Score =  130 bits (326), Expect = 5e-30
 Identities = 96/360 (26%), Positives = 159/360 (44%), Gaps = 42/360 (11%)

Query: 74  NAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
           NAA S +LD++  L  +  ++ + +    T L  A  + H   V+ L+   A ++  D+ 
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
           G T +  AAW G  EV+  L+ AG      + D  +AL  A    H  IV  L+Q  H  
Sbjct: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQ--HGA 668

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNS 253
           ++N+ D +GR   + AA  GH E++E L       + +D                   + 
Sbjct: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV------------------DG 710

Query: 254 IAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELN 313
             AL++   C P                      A  GH+  V +L+ +  +++  ++  
Sbjct: 711 RTALSVAALCVP----------------------ASKGHASVVSLLIDRGAEVDHCDKDG 748

Query: 314 ISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
           ++ L +A   GH  +V+ LL    D+        +PL       H +VVN+LL     +D
Sbjct: 749 MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVD 808

Query: 374 ILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            ++ + +T L +A+ +GNVE+V TLL  G D    D  G T L +A+   H L+   LI+
Sbjct: 809 SIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868



 Score =  120 bits (300), Expect = 5e-27
 Identities = 94/347 (27%), Positives = 160/347 (46%), Gaps = 19/347 (5%)

Query: 91  KVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVM 150
           K   +V +  +RT+           ++  LL + A V+  D +G T++  AA+SGSL+V+
Sbjct: 502 KAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVV 561

Query: 151 LMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAA 210
            +LV  GAD   ++  G + L  A +  H ++V  LI      ++N  D+ G      AA
Sbjct: 562 NLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIG--CGANINHTDQDGWTALRSAA 619

Query: 211 ERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVS 270
             GH E++  L +  +     D    + L  AA    +          +      G  V+
Sbjct: 620 WGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHED--------IVLNLLQHGAEVN 671

Query: 271 TSSVSLLQGGNTALHLAAKHGHSPAVQVLL-----AQWQDINEMNELNISSLQIATRNGH 325
            +       G TAL  AA  GH   V+ LL        +D++    L++++L +    GH
Sbjct: 672 KAD----NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGH 727

Query: 326 ASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHV 385
           AS+V+ L+    ++    +   +PL +     H+ VV+ LL    D+D  +   +TPL  
Sbjct: 728 ASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA 787

Query: 386 AADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           AA  G+  +V TLL  G  + ++D +G+T L++AS   +  VV  L+
Sbjct: 788 AASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL 834



 Score =  114 bits (286), Expect = 2e-25
 Identities = 93/362 (25%), Positives = 155/362 (42%), Gaps = 19/362 (5%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+  +  ++  L     NIN  +    TAL  A    H   V  LL    +VD AD   
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +  AAW G  +++L L++ GA+    + +G +AL  A    H  IVE+L+   H  +
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD--HGAE 702

Query: 195 LNQPDEKGRKPFLLA-----AERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
           +N  D  GR    +A     A +GH  ++  L          DK   + L  AA      
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAY----E 758

Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
               +  L +EG    G  V  +       G T L  AA  GH+  V  LL     ++ +
Sbjct: 759 GHVDVVDLLLEG----GADVDHTD----NNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810

Query: 310 NELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQ 369
           +    + L IA+  G+  +V  LL   +D + + +   +PLH+     H  +  +L+   
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870

Query: 370 HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVG 429
              + ++   + P  +A+  G+ + V+ LL+   ++      G+ AL VA+   H  +V 
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930

Query: 430 ML 431
           +L
Sbjct: 931 LL 932



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 41/139 (29%), Positives = 65/139 (46%)

Query: 295 AVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVV 354
           +++ LL     +N+ +    + L  A  +G   +VN L+S   DL  +     +PL L  
Sbjct: 527 SIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAA 586

Query: 355 INNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKT 414
              H  VVN L+    +I+  +Q   T L  AA  G+ E+V  LL AG  +   D   +T
Sbjct: 587 RQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRT 646

Query: 415 ALAVASRSNHSLVVGMLIK 433
           AL  A+   H  +V  L++
Sbjct: 647 ALRAAAWGGHEDIVLNLLQ 665



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 31/106 (29%), Positives = 53/106 (50%)

Query: 329 VNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAAD 388
           +  LL     ++Q      + L     +  + VVN L+S   D++I +    TPL +AA 
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587

Query: 389 RGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
           +G+ ++V  L+  G ++   D+ G TAL  A+   H+ VV  L+ A
Sbjct: 588 QGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 27/88 (30%), Positives = 47/88 (53%)

Query: 71   SFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVA 130
            + Q+AA   ++ +++ L E    ++   N   TAL  A    H+  V  LL+H A  + A
Sbjct: 1015 ALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHA 1074

Query: 131  DKHGLTVIHLAAWSGSLEVMLMLVKAGA 158
            D+ G T + +AA +G  +++ +L K GA
Sbjct: 1075 DQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  131 bits (329), Expect = 2e-30
 Identities = 98/359 (27%), Positives = 166/359 (46%), Gaps = 14/359 (3%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+  NL+++++L +   N N+ +  N TAL  A    H+  V+ LLK    ++  D  G
Sbjct: 45  AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +  A + G  +V+ +L+  GA+        +  + +A    H  IV  L+Q+     
Sbjct: 105 WTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG--AK 162

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           +N  D+ G  P + AA +GH+E ++ L  +     ++     + L  A       S   I
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEI 222

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
                    +P   ++         GNTAL +A+K GH+  VQ LL     +N  +    
Sbjct: 223 LKR------NPNVNLTDKD------GNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGD 270

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
           + L  A R GH  +V  LL +  D+  + +  ++ L+  V   + T+V  +L    D +I
Sbjct: 271 TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEI 330

Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
             +  +TPL  A    N+E+VE LL  G  + AVDK+G T L +A R     +  +L++
Sbjct: 331 CTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLR 389



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 65/245 (26%), Positives = 115/245 (46%), Gaps = 12/245 (4%)

Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
           KD+++ +E G+ P ++AAE+G++E++++L     + + +D   W    TA ++  K    
Sbjct: 29  KDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW----TALISASKEGHV 84

Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
            I    +E     G  +    +    GG TAL  A   G +  V++LL+   + +     
Sbjct: 85  HI----VEELLKCGVNLEHRDM----GGWTALMWACYKGRTDVVELLLSHGANPSVTGLY 136

Query: 313 NISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDI 372
           ++  +  A   GHA +V+ LL     ++   +   +PL       H+  V  LL+   D+
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADV 196

Query: 373 DILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           D       T L VA   G  + V+ +LK   ++   DK G TAL +AS+  H+ +V  L+
Sbjct: 197 DQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLL 256

Query: 433 KAERY 437
            A  Y
Sbjct: 257 DAGTY 261



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 30/80 (37%), Positives = 46/80 (57%)

Query: 354 VINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGK 413
           V   +I  + +LL    D+D  N+  QTPL +AA++GN+E+V+ L+K G +    D    
Sbjct: 13  VEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNW 72

Query: 414 TALAVASRSNHSLVVGMLIK 433
           TAL  AS+  H  +V  L+K
Sbjct: 73  TALISASKEGHVHIVEELLK 92



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 42/169 (24%), Positives = 86/169 (50%), Gaps = 10/169 (5%)

Query: 46  IPKREGLGE--EDTAVAGHELLLPNERS---FQNAAKSNNLDLMEKLFEKKVNINVVNNM 100
           I  +EG  E  +D   AG  + +P+         A +  +++++  L +K  +I++    
Sbjct: 242 IASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQD 301

Query: 101 NRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQ 160
           N+TAL++AV + + + V  +L+     ++  K G T +  A    ++EV+ +L+  GA  
Sbjct: 302 NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKV 361

Query: 161 RAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD---LNQPDEKGRKPF 206
            A ++ G + LH A +    ++ E L++  + KD   L +P++ G  P+
Sbjct: 362 SAVDKKGDTPLHIAIRGRSRKLAELLLR--NPKDGRLLYRPNKAGETPY 408


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  125 bits (315), Expect = 9e-29
 Identities = 101/392 (25%), Positives = 172/392 (43%), Gaps = 25/392 (6%)

Query: 42  SLSRIPKREGLGEEDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMN 101
           S  R P    LG  D            ++   +A  S +   + K+ + + ++++  +  
Sbjct: 390 SFEREPSTSDLGTTDV----------QKKKLVDAIVSGDTSKLMKILQPQ-DVDLALDSG 438

Query: 102 RTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQR 161
            + LH AV         +LL + A  +++++ G T +H+A       V+ +L+       
Sbjct: 439 ASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVN 498

Query: 162 AKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
           AK++D  +ALHFA Q+        L++      +N+ D +GR P  +A + G   ++  L
Sbjct: 499 AKDEDQWTALHFAAQNGDESSTRLLLEKN--ASVNEVDFEGRTPMHVACQHGQENIVRIL 556

Query: 222 TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN 281
               +  S + K  W  L  AA             L I    +   GVS ++ +L   G 
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQ---------GHLPIVKLLAKQPGVSVNAQTL--DGR 605

Query: 282 TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQ 341
           T LHLAA+ GH    ++L+    D+N  + L  + L +A   GH S    LL        
Sbjct: 606 TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA 665

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
                 + LHL   N H+  V  L+  + D+       QT LH+AA  G+ E+VE L+ A
Sbjct: 666 MTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA 725

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
              +   D+QG +AL +A++  H+  V  L++
Sbjct: 726 DV-IDLFDEQGLSALHLAAQGRHAQTVETLLR 756


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  119 bits (299), Expect = 6e-27
 Identities = 101/357 (28%), Positives = 149/357 (41%), Gaps = 14/357 (3%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+    DL   L     + N V+      LHFA           LL H A VD  ++ G
Sbjct: 402 AAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG 461

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +HLAA +    V  +LV   AD      +G + LH A    HV +V+ L       +
Sbjct: 462 WTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG--AE 519

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           L+      R P  LA ERG V  I+ L          D+  +  L TAA      +R   
Sbjct: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAA------ARGKY 573

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
                   C        S       G T LHLAA  GH   + +L     ++  +  +N 
Sbjct: 574 LI------CKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNW 627

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDI 374
           + L +A R+G  ++V+ LL    D +   +   +PLHL V  +    V +LL    ++  
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687

Query: 375 LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
            N+   TP H+AA +GN  +++ L++AG  L   D    T L +A RS    ++  L
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744



 Score =  104 bits (259), Expect = 3e-22
 Identities = 99/395 (25%), Positives = 164/395 (41%), Gaps = 44/395 (11%)

Query: 69  ERSFQNAAKSNNLDLMEKL--FEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKAR 126
           +R+ Q + + N +   E+L  +E KV          T LHF V +  +  V  LL H+  
Sbjct: 338 KRALQLSDRKNLVPRDEELCIYENKV----------TPLHFLVAQGSVEQVRLLLAHEVD 387

Query: 127 VDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYL 186
           VD     G T + +AA     ++  +L+  GAD    ++DG + LHFA Q+        L
Sbjct: 388 VDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLL 447

Query: 187 IQDLHLKDLNQPDEKGRKPFLLAAERGHVE----MIEKLTFLNLHTSE-KDKIQWSTLWT 241
           +   H   ++  + +G  P  LAA+         ++ +    NLH +E K  +  +  + 
Sbjct: 448 LD--HGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFG 505

Query: 242 -AALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLL 300
             +L K+ TS+              G  +     +L     T LHLA + G   A+Q LL
Sbjct: 506 HVSLVKLLTSQ--------------GAELDAQQRNL----RTPLHLAVERGKVRAIQHLL 547

Query: 301 AQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHIT 360
                 + +++     L  A   G   +   LL     L        +PLHL     H+ 
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607

Query: 361 VVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVA- 419
           +++ L  +  ++  L     TPLH+AA  G   +V  LL+ G D  A ++ G T L +A 
Sbjct: 608 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667

Query: 420 SRSNHSLVVGML-----IKAERYYAWREEHHESIR 449
            RS    V+ +L     + A     W   H  +++
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALK 702



 Score = 95.9 bits (237), Expect = 1e-19
 Identities = 86/355 (24%), Positives = 149/355 (41%), Gaps = 14/355 (3%)

Query: 80  NLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIH 139
           +++ +  L   +V+++       T L  A           LL H A  +  D+ G   +H
Sbjct: 374 SVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLH 433

Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
            AA +G      +L+  GA   A+ ++G + LH A Q+N   +   L+      D N  +
Sbjct: 434 FAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVS--RQADPNLHE 491

Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI 259
            +G+ P  +AA  GHV +++ LT      +E D  Q +      L   +    +I  L  
Sbjct: 492 AEGKTPLHVAAYFGHVSLVKLLTSQG---AELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548

Query: 260 EGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQI 319
            GA            +L Q G   LH AA  G     ++LL     +        + L +
Sbjct: 549 SGAVPD---------ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHL 599

Query: 320 ATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ 379
           A   GH  +++ L   + ++        +PLHL   +    VV++LL    D +   Q  
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659

Query: 380 QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            TPLH+A  R     V  LL+   ++ A +K G T   +A+   ++ ++ +L++A
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEA 714


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  117 bits (293), Expect = 3e-26
 Identities = 91/367 (24%), Positives = 177/367 (48%), Gaps = 24/367 (6%)

Query: 70  RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV 129
           RS  + A+S++    E  F  K  I+ +N+ N   L   +G   LS  D        V+ 
Sbjct: 325 RSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGS--LSNYD--------VNQ 374

Query: 130 ADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQD 189
            +KHG   + +AA  G+++++ +L+K G+    +++ G +A+++A +  HV  +++L ++
Sbjct: 375 PNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSEN 434

Query: 190 LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
               D+   D+ G     +AA  GH ++ + L     + + +DK + + L  AA     +
Sbjct: 435 KCPLDVK--DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYS 492

Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
              ++        C  G  V+  +    + G T L  A+  G+   V+ L     D+N  
Sbjct: 493 VAKAL--------CEAGCNVNIKN----REGETPLLTASARGYHDIVECLAEHGADLNAC 540

Query: 310 NELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQ 369
           ++    +L +A R     ++  LLS+   +  +     +PLH+   + ++ +V +L  A 
Sbjct: 541 DKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEAN 600

Query: 370 HDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVG 429
            ++DI N+  +TPLH+AA+ G +++V  L   G  ++A+   GKTA  +A    H  V G
Sbjct: 601 CNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAG 660

Query: 430 MLIKAER 436
           +L +  +
Sbjct: 661 LLARLRK 667



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 71/291 (24%), Positives = 131/291 (45%), Gaps = 47/291 (16%)

Query: 156 AGADQRAKNQDG--MSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERG 213
           A +D     +D   M A+  A   ++V  +++L+  L   D+NQP++ G  P L+AA  G
Sbjct: 331 ARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCG 390

Query: 214 HVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSS 273
           ++++++ L         +DK                                        
Sbjct: 391 NIQILQLLIKRGSRIDVQDK---------------------------------------- 410

Query: 274 VSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLL 333
                GG+ A++ AA+HGH   ++ L      ++  ++    +L +A R GHA +   L 
Sbjct: 411 -----GGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLC 465

Query: 334 SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVE 393
           S   + + + + +E+PLH    + + +V  +L  A  +++I N++ +TPL  A+ RG  +
Sbjct: 466 SFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHD 525

Query: 394 LVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREEH 444
           +VE L + G DL A DK G  AL +A R     V+  L+    +  +++ H
Sbjct: 526 IVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRH 576



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 69/267 (25%), Positives = 109/267 (40%), Gaps = 14/267 (5%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA+  ++D ++ L E K  ++V +     ALH A    H      L    +  ++ DK  
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEE 478

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKD 194
            T +H AAW G   V   L +AG +   KN++G + L  A+   +  IVE L +  H  D
Sbjct: 479 ETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAE--HGAD 536

Query: 195 LNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
           LN  D+ G     LA  R  +E+I+ L         +D+   + L  A     K     I
Sbjct: 537 LNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVAC----KDGNMPI 592

Query: 255 AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
                E  C+    +  S+    + G T LHLAA +G    V+ L      +  +     
Sbjct: 593 VVALCEANCN----LDISN----KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGK 644

Query: 315 SSLQIATRNGHASLVNFLLSENVDLHQ 341
           ++  +A    H  +   L     D H+
Sbjct: 645 TAEDLARSEQHEHVAGLLARLRKDTHR 671



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 54/231 (23%), Positives = 94/231 (40%), Gaps = 14/231 (6%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E +   AA+  + D+ + L     N N+ +    T LH A    + S    L +    V+
Sbjct: 446 EMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVN 505

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           + ++ G T +  A+  G  +++  L + GAD  A ++DG  ALH A +   + +++ L+ 
Sbjct: 506 IKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLS 565

Query: 189 DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMK 248
                D    D  G  P  +A + G++ ++  L   N +    +K   + L  AA     
Sbjct: 566 QGCFVDYQ--DRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAA----- 618

Query: 249 TSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVL 299
              N+     +   C  G  V     +L   G TA  LA    H     +L
Sbjct: 619 ---NNGILDVVRYLCLMGASVE----ALTTDGKTAEDLARSEQHEHVAGLL 662


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
           sapiens]
          Length = 2603

 Score =  113 bits (282), Expect = 6e-25
 Identities = 92/333 (27%), Positives = 155/333 (46%), Gaps = 17/333 (5%)

Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
           T L  A    H+  V  LL HKA V+     G T +  A   G ++V+ +L+++GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 163 KNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLT 222
            N++G + L  A  + HV +   L+++    + +  + K      LA  +GH+EM+  L 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK-ESALTLACYKGHLEMVRFL- 420

Query: 223 FLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNT 282
              L      + +   + TA +         +A L ++     G  V+  + S      +
Sbjct: 421 ---LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS----GAQVNMPADSF----ES 469

Query: 283 ALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH-Q 341
            L LAA  GH     +L+ +   + E+N+   + L  A R GH  +V  LL +  +++ Q
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
             E +E+ L L      + V + L+ A  DI++      TPL  AA  G++ELV+ LL A
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAA 586

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
           G ++ A    G TAL  A  + H+ V  +L++A
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQA 619



 Score =  106 bits (265), Expect = 5e-23
 Identities = 99/381 (25%), Positives = 159/381 (41%), Gaps = 27/381 (7%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
           A     +D+++ L E   +I   N    T L  A    H+     LL++ A ++  +++ 
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
             + + LA + G LE++  L++AGADQ  K  +  +AL  A    HV +   L+      
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--A 458

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------- 245
            +N P +    P  LAA  GHVE+   L        E +   ++ L  AA          
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518

Query: 246 --------KMKTSRNSIAALTIEGACSPG-----TGVSTSSVSLLQGGNTALHLAAKHGH 292
                     +T      ALT+  AC  G       +  +   +  G +T L  AA+ GH
Sbjct: 519 LLGQGANINAQTEETQETALTL--ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576

Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
              V+ LLA   +++       ++L  A  NGH  + + LL    DL  + E   +PL  
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 353 VVINNHITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQ 411
                H+  V  L+S   +++        T L +A   G++ +VE LL  G D     K 
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696

Query: 412 GKTALAVASRSNHSLVVGMLI 432
           G T L  A++  H+ VV  L+
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLL 717



 Score =  104 bits (260), Expect = 2e-22
 Identities = 91/336 (27%), Positives = 151/336 (44%), Gaps = 18/336 (5%)

Query: 103  TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
            TAL  A    H   V  LL+  A ++  DK G T + LAA +G + V+ +L+  GAD  A
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144

Query: 163  KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
            +++      L  A       +VE L+     K+     +    P  LAA  G+V +I+ L
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 1202

Query: 222  TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
                   + +   K+  S L  AA+        +   L ++        + T+       
Sbjct: 1203 LNAGAEINSRTGSKLGISPLMLAAMN----GHTAAVKLLLDMGSDINAQIETNR------ 1252

Query: 280  GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
             NTAL LA   G +  V +LL +  ++    +  ++ L  A   G+A +   LL +  D+
Sbjct: 1253 -NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1311

Query: 340  HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
            +    P  +++ L +     H      L+     ID+ N+K  TPL +AA+ G++++V+ 
Sbjct: 1312 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371

Query: 398  LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            L++AG D+ A D +  T L  A R  H  VV  L+K
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 96/383 (25%), Positives = 156/383 (40%), Gaps = 54/383 (14%)

Query: 55  EDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHL 114
           E TA AG      + RS   A    +++ + KL  +  ++N       + L  A    + 
Sbjct: 225 ESTANAGQS----DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280

Query: 115 SAVDFLLKHKARV-DVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHF 173
                LL   A V D   K  +T +  AA  G ++++ +L+   AD  A++  G +AL +
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340

Query: 174 ATQSNHVRIVEYLIQD-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKD 232
           A    +V +V+ L++    ++D N   E G  P + A   GHVE                
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHN---ENGHTPLMEAGSAGHVE---------------- 381

Query: 233 KIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGH 292
                                +A L +E     G G++T S    +   +AL LA   GH
Sbjct: 382 ---------------------VARLLLEN----GAGINTHSNEFKE---SALTLACYKGH 413

Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
              V+ LL    D     +   ++L  A  +GH  +   LL     ++   +  ESPL L
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 353 VVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKA-VDKQ 411
                H+ +   L+     ++ +N +  TPL  AA  G+ E+V  LL  G ++ A  ++ 
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533

Query: 412 GKTALAVASRSNHSLVVGMLIKA 434
            +TAL +A       V   LIKA
Sbjct: 534 QETALTLACCGGFLEVADFLIKA 556



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 80/303 (26%), Positives = 143/303 (47%), Gaps = 16/303 (5%)

Query: 136  TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
            T + LA   G  E++  L++ GA    +++ G + L  A  + HV +VE L+ +    D+
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG--ADI 1142

Query: 196  NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
                E+ +  P  LA   G  E++E L     +   ++   ++ L  AA      S   +
Sbjct: 1143 EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA------SGGYV 1196

Query: 255  AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
              + I    + G  +++ + S L  G + L LAA +GH+ AV++LL    DIN   E N 
Sbjct: 1197 NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252

Query: 315  SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            ++ L +A   G   +V+ LL    ++  + +   +PL       +  V   LL    D++
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312

Query: 374  I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
               +   + T L +AAD+G+ +  E L+  G  +   +K+G T L +A+   H  VV +L
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372

Query: 432  IKA 434
            ++A
Sbjct: 1373 VQA 1375



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 48/155 (30%), Positives = 75/155 (48%), Gaps = 3/155 (1%)

Query: 281  NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
            +TAL LA   GH   VQ LL +   I   ++   + L +A   GH  +V  LL    D+ 
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143

Query: 341  -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
             Q    K++PL L        VV  LL+   + +  N    TPL +AA  G V +++ LL
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203

Query: 400  KAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
             AG ++  +   K G + L +A+ + H+  V +L+
Sbjct: 1204 NAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 1238



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 44/141 (31%), Positives = 74/141 (52%), Gaps = 13/141 (9%)

Query: 64   LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
            LLL  + + ++ AK+    LME            L +K  ++N   V +   TAL  A  
Sbjct: 1270 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1329

Query: 111  RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
            + H    + L+   A +DV +K G T + LAA  G L+V+ +LV+AGAD  A +   ++ 
Sbjct: 1330 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1389

Query: 171  LHFATQSNHVRIVEYLIQDLH 191
            L  A +  HV++V YL+++++
Sbjct: 1390 LMAAFRKGHVKVVRYLVKEVN 1410



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 29/288 (10%)

Query: 75   AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
            AA + ++ ++E L +   +I   +   + T L  A        V+ LL   A  +  +  
Sbjct: 1123 AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182

Query: 134  GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
              T + LAA  G + ++ +L+ AGA+   R  ++ G+S L  A  + H   V+ L+ D+ 
Sbjct: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL-DMG 1241

Query: 192  LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
              D+N   E  R   L LA  +G  E++  L     +   + K   + L  AA       
Sbjct: 1242 -SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1300

Query: 244  ------------LTKMKTSRNSIAALTIEGA----CSPGTGVSTSSVSLLQGGNTALHLA 287
                           + +SR++   +  +      C    G         + GNT L LA
Sbjct: 1301 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1360

Query: 288  AKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
            A  GH   VQ+L+    D++  +   I+ L  A R GH  +V +L+ E
Sbjct: 1361 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1408



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 1/127 (0%)

Query: 62  HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
           H      + +   A ++ + D+ + L +   ++   +   RT L  A    H+  V FL+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650

Query: 122 KHKARVD-VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
              A V+     +  TV+ LA   G L V+ +L+  GAD   + +DG + L  A +  H 
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710

Query: 181 RIVEYLI 187
            +V YL+
Sbjct: 711 SVVCYLL 717


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
           sapiens]
          Length = 2352

 Score =  113 bits (282), Expect = 6e-25
 Identities = 92/333 (27%), Positives = 155/333 (46%), Gaps = 17/333 (5%)

Query: 103 TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
           T L  A    H+  V  LL HKA V+     G T +  A   G ++V+ +L+++GA    
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362

Query: 163 KNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLT 222
            N++G + L  A  + HV +   L+++    + +  + K      LA  +GH+EM+  L 
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFK-ESALTLACYKGHLEMVRFL- 420

Query: 223 FLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNT 282
              L      + +   + TA +         +A L ++     G  V+  + S      +
Sbjct: 421 ---LEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS----GAQVNMPADSF----ES 469

Query: 283 ALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH-Q 341
            L LAA  GH     +L+ +   + E+N+   + L  A R GH  +V  LL +  +++ Q
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKA 401
             E +E+ L L      + V + L+ A  DI++      TPL  AA  G++ELV+ LL A
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLELVKYLLAA 586

Query: 402 GCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
           G ++ A    G TAL  A  + H+ V  +L++A
Sbjct: 587 GANVHATTATGDTALTYACENGHTDVADVLLQA 619



 Score =  106 bits (265), Expect = 5e-23
 Identities = 99/381 (25%), Positives = 159/381 (41%), Gaps = 27/381 (7%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
           A     +D+++ L E   +I   N    T L  A    H+     LL++ A ++  +++ 
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
             + + LA + G LE++  L++AGADQ  K  +  +AL  A    HV +   L+      
Sbjct: 401 KESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--A 458

Query: 194 DLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------- 245
            +N P +    P  LAA  GHVE+   L        E +   ++ L  AA          
Sbjct: 459 QVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVAL 518

Query: 246 --------KMKTSRNSIAALTIEGACSPG-----TGVSTSSVSLLQGGNTALHLAAKHGH 292
                     +T      ALT+  AC  G       +  +   +  G +T L  AA+ GH
Sbjct: 519 LLGQGANINAQTEETQETALTL--ACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGH 576

Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
              V+ LLA   +++       ++L  A  NGH  + + LL    DL  + E   +PL  
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636

Query: 353 VVINNHITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQ 411
                H+  V  L+S   +++        T L +A   G++ +VE LL  G D     K 
Sbjct: 637 AARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKD 696

Query: 412 GKTALAVASRSNHSLVVGMLI 432
           G T L  A++  H+ VV  L+
Sbjct: 697 GSTMLIEAAKGGHTSVVCYLL 717



 Score =  104 bits (260), Expect = 2e-22
 Identities = 91/336 (27%), Positives = 151/336 (44%), Gaps = 18/336 (5%)

Query: 103  TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
            TAL  A    H   V  LL+  A ++  DK G T + LAA +G + V+ +L+  GAD  A
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893

Query: 163  KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
            +++      L  A       +VE L+     K+     +    P  LAA  G+V +I+ L
Sbjct: 894  QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 951

Query: 222  TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
                   + +   K+  S L  AA+        +   L ++        + T+       
Sbjct: 952  LNAGAEINSRTGSKLGISPLMLAAMN----GHTAAVKLLLDMGSDINAQIETNR------ 1001

Query: 280  GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
             NTAL LA   G +  V +LL +  ++    +  ++ L  A   G+A +   LL +  D+
Sbjct: 1002 -NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1060

Query: 340  HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
            +    P  +++ L +     H      L+     ID+ N+K  TPL +AA+ G++++V+ 
Sbjct: 1061 NAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120

Query: 398  LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            L++AG D+ A D +  T L  A R  H  VV  L+K
Sbjct: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 100/398 (25%), Positives = 167/398 (41%), Gaps = 28/398 (7%)

Query: 62  HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
           H      + +   A ++ + D+ + L +   ++   +   RT L  A    H+  V FL+
Sbjct: 591 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLI 650

Query: 122 KHKARVD-VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
              A V+     +  TV+ LA   G L V+ +L+  GAD   + +DG + L  A +  H 
Sbjct: 651 SKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 710

Query: 181 RIVEYLIQ-DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDK------ 233
            +V YL+    +L     PD     P      R     ++ L  + +   E DK      
Sbjct: 711 SVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMV-VPPQEPDKPPANVA 769

Query: 234 ----IQWSTLWTAALTKMKTSRNSIAA-LTIEGACSPGTGVSTSSVSLL----------- 277
               I+   +   A     T  +SIAA ++     +P   +S S++  +           
Sbjct: 770 TTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTE 829

Query: 278 QGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENV 337
              +TAL LA   GH   VQ LL +   I   ++   + L +A   GH  +V  LL    
Sbjct: 830 SNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGA 889

Query: 338 DLH-QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVE 396
           D+  Q    K++PL L        VV  LL+   + +  N    TPL +AA  G V +++
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIK 949

Query: 397 TLLKAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
            LL AG ++  +   K G + L +A+ + H+  V +L+
Sbjct: 950 ILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL 987



 Score = 96.7 bits (239), Expect = 6e-20
 Identities = 96/383 (25%), Positives = 156/383 (40%), Gaps = 54/383 (14%)

Query: 55  EDTAVAGHELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHL 114
           E TA AG      + RS   A    +++ + KL  +  ++N       + L  A    + 
Sbjct: 225 ESTANAGQS----DNRSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYY 280

Query: 115 SAVDFLLKHKARV-DVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHF 173
                LL   A V D   K  +T +  AA  G ++++ +L+   AD  A++  G +AL +
Sbjct: 281 ELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTY 340

Query: 174 ATQSNHVRIVEYLIQD-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKD 232
           A    +V +V+ L++    ++D N   E G  P + A   GHVE                
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHN---ENGHTPLMEAGSAGHVE---------------- 381

Query: 233 KIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGH 292
                                +A L +E     G G++T S    +   +AL LA   GH
Sbjct: 382 ---------------------VARLLLEN----GAGINTHSNEFKE---SALTLACYKGH 413

Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHL 352
              V+ LL    D     +   ++L  A  +GH  +   LL     ++   +  ESPL L
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTL 473

Query: 353 VVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKA-VDKQ 411
                H+ +   L+     ++ +N +  TPL  AA  G+ E+V  LL  G ++ A  ++ 
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEET 533

Query: 412 GKTALAVASRSNHSLVVGMLIKA 434
            +TAL +A       V   LIKA
Sbjct: 534 QETALTLACCGGFLEVADFLIKA 556



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 80/303 (26%), Positives = 143/303 (47%), Gaps = 16/303 (5%)

Query: 136  TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
            T + LA   G  E++  L++ GA    +++ G + L  A  + HV +VE L+ +    D+
Sbjct: 834  TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG--ADI 891

Query: 196  NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
                E+ +  P  LA   G  E++E L     +   ++   ++ L  AA      S   +
Sbjct: 892  EAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAA------SGGYV 945

Query: 255  AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
              + I    + G  +++ + S L  G + L LAA +GH+ AV++LL    DIN   E N 
Sbjct: 946  NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1001

Query: 315  SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            ++ L +A   G   +V+ LL    ++  + +   +PL       +  V   LL    D++
Sbjct: 1002 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061

Query: 374  I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
               +   + T L +AAD+G+ +  E L+  G  +   +K+G T L +A+   H  VV +L
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121

Query: 432  IKA 434
            ++A
Sbjct: 1122 VQA 1124



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 44/141 (31%), Positives = 74/141 (52%), Gaps = 13/141 (9%)

Query: 64   LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
            LLL  + + ++ AK+    LME            L +K  ++N   V +   TAL  A  
Sbjct: 1019 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1078

Query: 111  RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
            + H    + L+   A +DV +K G T + LAA  G L+V+ +LV+AGAD  A +   ++ 
Sbjct: 1079 KGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITP 1138

Query: 171  LHFATQSNHVRIVEYLIQDLH 191
            L  A +  HV++V YL+++++
Sbjct: 1139 LMAAFRKGHVKVVRYLVKEVN 1159



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 29/288 (10%)

Query: 75   AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
            AA + ++ ++E L +   +I   +   + T L  A        V+ LL   A  +  +  
Sbjct: 872  AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 931

Query: 134  GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
              T + LAA  G + ++ +L+ AGA+   R  ++ G+S L  A  + H   V+ L+ D+ 
Sbjct: 932  DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLL-DMG 990

Query: 192  LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
              D+N   E  R   L LA  +G  E++  L     +   + K   + L  AA       
Sbjct: 991  -SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1049

Query: 244  ------------LTKMKTSRNSIAALTIEGA----CSPGTGVSTSSVSLLQGGNTALHLA 287
                           + +SR++   +  +      C    G         + GNT L LA
Sbjct: 1050 GRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1109

Query: 288  AKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
            A  GH   VQ+L+    D++  +   I+ L  A R GH  +V +L+ E
Sbjct: 1110 ANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKE 1157


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  108 bits (270), Expect = 1e-23
 Identities = 96/375 (25%), Positives = 158/375 (42%), Gaps = 27/375 (7%)

Query: 81  LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
           +D+++ L  +  NI   N    T L  A    H+     LL H A ++  +++   + + 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
           LA + G L+++  L++AGADQ  K  +  +AL  A    HV +   L+       +N P 
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 435

Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------------- 245
           +    P  LAA  GHVE+   L     +  E +   ++ L  AA                
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 246 --KMKTSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQV 298
               +T      ALT+  AC  G       +  +   +  G +T L  A++ GH   V+ 
Sbjct: 496 NINAQTEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553

Query: 299 LLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH 358
           LLA   +++       ++L  A  NGH  + + LL    DL  + E   +PL       H
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613

Query: 359 ITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALA 417
           +  V  L+S   +++        T + +A   G++ +VE LL  G D     K G T L 
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673

Query: 418 VASRSNHSLVVGMLI 432
            A++  H+ VV  L+
Sbjct: 674 EAAKGGHTNVVSYLL 688



 Score =  106 bits (265), Expect = 5e-23
 Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)

Query: 70  RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
           RS   A    +++ + KL ++  ++N       + L  A    +      LL   A V D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
             +K  +T +  A+  G L+++ +L+   AD  +++  G +AL +A     V IV+ L+ 
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
           +  +++D N   E G  P + AA  GHVE+   L      +N H++E             
Sbjct: 327 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
             D +++  L   A  + KT     A +    AC  G  V  + + L  G          
Sbjct: 384 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 438

Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
            + L LAA  GH     +L+ +  ++ E+N+   + L  A R GH  +V  LL++  +++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498

Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
            Q  E +E+ L L        V + L+ A  DI++      TPL  A+  G++ELV+ LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 555

Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            +G ++ A    G TAL  A  + H+ V  +L++A
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 87/336 (25%), Positives = 148/336 (44%), Gaps = 18/336 (5%)

Query: 103  TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
            TAL  A    H   V  L+   A+++  DK G T + LAA +G + V+ +L+  G D  A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 163  KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
            +++      L  A       +V+ L+     K+     +    P  LAA  G+V +I+ L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 1174

Query: 222  TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
                   + +   K+  S L  AA+            L ++        + T+       
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMN----GHVPAVKLLLDMGSDINAQIETNR------ 1224

Query: 280  GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
             NTAL LA   G +  V +LL +  ++    +  ++ L  A   G+A +   LL +  D+
Sbjct: 1225 -NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 340  HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
            +    P  +++ L +     H      L+     ID+ N+K  TPL +A++ G+ ++V+ 
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 398  LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            L++AG D+ A D +  T L  A R  H  VV  L+K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 81/303 (26%), Positives = 142/303 (46%), Gaps = 16/303 (5%)

Query: 136  TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
            T + LA   G  E++ +L+   A    +++ G + L  A  + HV +VE L+      D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG--DI 1114

Query: 196  NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
                E+ +  P  LA   G  E+++ L     +   ++   ++ L  AA      S   +
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA------SGGYV 1168

Query: 255  AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
              + I    + G  +++ + S L  G + L LAA +GH PAV++LL    DIN   E N 
Sbjct: 1169 NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 315  SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            ++ L +A   G A +V+ LL    ++  + +   +PL       +  V   LL    D++
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 374  I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
               +   + T L +AAD+G+ +  E L+  G  +   +K+G T L +AS   H  VV +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 432  IKA 434
            ++A
Sbjct: 1345 VQA 1347



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 3/155 (1%)

Query: 281  NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
            +TAL LA   GH   V VL+A+   I   ++   + L +A   GH  +V  LL +  D+ 
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 341  -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
             Q    K++PL L        VV+ LL+   + +  N    TPL +AA  G V +++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 400  KAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
             AG ++  +   K G + L +A+ + H   V +L+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 76/294 (25%), Positives = 125/294 (42%), Gaps = 41/294 (13%)

Query: 75   AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
            AA + ++ ++E L +K  +I   +   + T L  A        VD LL   A  +  +  
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154

Query: 134  GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
              T + LAA  G + ++ +L+ AGA+   R  ++ G+S L  A  + HV  V+ L+ D+ 
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL-DMG 1213

Query: 192  LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
              D+N   E  R   L LA  +G  E++  L     +   + K   + L  AA       
Sbjct: 1214 -SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272

Query: 244  ------------LTKMKTSRNSIAALTI----------EGACSPGTGVSTSSVSLLQGGN 281
                           + +SR++  ALTI          E     G  +   +    + GN
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIHRGAHIDVRN----KKGN 1326

Query: 282  TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
            T L LA+  GH   VQ+L+    D++  +   I+ L  A R GH  +V +L+ E
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 65/261 (24%), Positives = 110/261 (42%), Gaps = 19/261 (7%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
           AA   +++L   L E+  N+  VN+   T L  A    H   V  LL   A ++   ++ 
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA-LHFATQSNHVRIVEYLIQDLHL 192
             T + LA   G  EV   L+KAGAD       G S  L  A+Q  H+ +V+YL+     
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIEL----GCSTPLMEASQEGHLELVKYLLASG-- 558

Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
            +++     G      A E GH ++ + L         + +           T +  +  
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE--------GGRTPLMKAAR 610

Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
           +    T++   S G  V+ ++ +     +T + LA   GH   V++LLA   D     + 
Sbjct: 611 AGHLCTVQFLISKGANVNRATAN---NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKD 667

Query: 313 NISSLQIATRNGHASLVNFLL 333
             + L  A + GH ++V++LL
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLL 688



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 13/141 (9%)

Query: 64   LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
            LLL  + + ++ AK+    LME            L +K  ++N   V +   TAL  A  
Sbjct: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301

Query: 111  RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
            + H    + L+   A +DV +K G T + LA+  G  +V+ +LV+AGAD  A +   ++ 
Sbjct: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361

Query: 171  LHFATQSNHVRIVEYLIQDLH 191
            L  A +  HV++V+YL+++++
Sbjct: 1362 LMSAFRKGHVKVVQYLVKEVN 1382



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 63/248 (25%), Positives = 103/248 (41%), Gaps = 25/248 (10%)

Query: 75  AAKSNNLDLMEKLFEKKVNINV-VNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
           AA+  + +++  L  +  NIN        TAL  A         DFL+K  A +++    
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS- 536

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
             T +  A+  G LE++  L+ +GA+  A    G +AL +A ++ H  + + L+Q     
Sbjct: 537 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG--A 592

Query: 194 DLNQPDEKGRKPFLLAAERGHV----EMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
           DL    E GR P + AA  GH+     +I K   +N  T+  D        T        
Sbjct: 593 DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH-------TVVSLACAG 645

Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
              ++  L +     P           L+ G+T L  AAK GH+  V  LL    ++  +
Sbjct: 646 GHLAVVELLLAHGADP--------THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 697

Query: 310 NELNISSL 317
              ++S L
Sbjct: 698 PTTDVSQL 705



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/127 (27%), Positives = 59/127 (46%), Gaps = 1/127 (0%)

Query: 62  HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
           H      + +   A ++ + D+ + L +   ++   +   RT L  A    HL  V FL+
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621

Query: 122 KHKARVDVADKHG-LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
              A V+ A  +   TV+ LA   G L V+ +L+  GAD   + +DG + L  A +  H 
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681

Query: 181 RIVEYLI 187
            +V YL+
Sbjct: 682 NVVSYLL 688


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  108 bits (270), Expect = 1e-23
 Identities = 96/375 (25%), Positives = 158/375 (42%), Gaps = 27/375 (7%)

Query: 81  LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
           +D+++ L  +  NI   N    T L  A    H+     LL H A ++  +++   + + 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
           LA + G L+++  L++AGADQ  K  +  +AL  A    HV +   L+       +N P 
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 435

Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-------------- 245
           +    P  LAA  GHVE+   L     +  E +   ++ L  AA                
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGA 495

Query: 246 --KMKTSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQV 298
               +T      ALT+  AC  G       +  +   +  G +T L  A++ GH   V+ 
Sbjct: 496 NINAQTEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKY 553

Query: 299 LLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH 358
           LLA   +++       ++L  A  NGH  + + LL    DL  + E   +PL       H
Sbjct: 554 LLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 613

Query: 359 ITVVNSLLSAQHDIDILN-QKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALA 417
           +  V  L+S   +++        T + +A   G++ +VE LL  G D     K G T L 
Sbjct: 614 LCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLI 673

Query: 418 VASRSNHSLVVGMLI 432
            A++  H+ VV  L+
Sbjct: 674 EAAKGGHTNVVSYLL 688



 Score =  106 bits (265), Expect = 5e-23
 Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)

Query: 70  RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
           RS   A    +++ + KL ++  ++N       + L  A    +      LL   A V D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
             +K  +T +  A+  G L+++ +L+   AD  +++  G +AL +A     V IV+ L+ 
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
           +  +++D N   E G  P + AA  GHVE+   L      +N H++E             
Sbjct: 327 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
             D +++  L   A  + KT     A +    AC  G  V  + + L  G          
Sbjct: 384 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 438

Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
            + L LAA  GH     +L+ +  ++ E+N+   + L  A R GH  +V  LL++  +++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498

Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
            Q  E +E+ L L        V + L+ A  DI++      TPL  A+  G++ELV+ LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 555

Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            +G ++ A    G TAL  A  + H+ V  +L++A
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 87/336 (25%), Positives = 148/336 (44%), Gaps = 18/336 (5%)

Query: 103  TALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRA 162
            TAL  A    H   V  L+   A+++  DK G T + LAA +G + V+ +L+  G D  A
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116

Query: 163  KNQDGMSA-LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL 221
            +++      L  A       +V+ L+     K+     +    P  LAA  G+V +I+ L
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY--TPLSLAASGGYVNIIKIL 1174

Query: 222  TFLNLHTSEK--DKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG 279
                   + +   K+  S L  AA+            L ++        + T+       
Sbjct: 1175 LNAGAEINSRTGSKLGISPLMLAAMN----GHVPAVKLLLDMGSDINAQIETNR------ 1224

Query: 280  GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 339
             NTAL LA   G +  V +LL +  ++    +  ++ L  A   G+A +   LL +  D+
Sbjct: 1225 -NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADV 1283

Query: 340  HQKVEP--KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVET 397
            +    P  +++ L +     H      L+     ID+ N+K  TPL +A++ G+ ++V+ 
Sbjct: 1284 NAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 398  LLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
            L++AG D+ A D +  T L  A R  H  VV  L+K
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 81/303 (26%), Positives = 142/303 (46%), Gaps = 16/303 (5%)

Query: 136  TVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDL 195
            T + LA   G  E++ +L+   A    +++ G + L  A  + HV +VE L+      D+
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGG--DI 1114

Query: 196  NQPDEKGRK-PFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSI 254
                E+ +  P  LA   G  E+++ L     +   ++   ++ L  AA      S   +
Sbjct: 1115 EAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAA------SGGYV 1168

Query: 255  AALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNI 314
              + I    + G  +++ + S L  G + L LAA +GH PAV++LL    DIN   E N 
Sbjct: 1169 NIIKI--LLNAGAEINSRTGSKL--GISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 315  SS-LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            ++ L +A   G A +V+ LL    ++  + +   +PL       +  V   LL    D++
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 374  I--LNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGML 431
               +   + T L +AAD+G+ +  E L+  G  +   +K+G T L +AS   H  VV +L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344

Query: 432  IKA 434
            ++A
Sbjct: 1345 VQA 1347



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 48/155 (30%), Positives = 77/155 (49%), Gaps = 3/155 (1%)

Query: 281  NTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
            +TAL LA   GH   V VL+A+   I   ++   + L +A   GH  +V  LL +  D+ 
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115

Query: 341  -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
             Q    K++PL L        VV+ LL+   + +  N    TPL +AA  G V +++ LL
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175

Query: 400  KAGCDL--KAVDKQGKTALAVASRSNHSLVVGMLI 432
             AG ++  +   K G + L +A+ + H   V +L+
Sbjct: 1176 NAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 76/294 (25%), Positives = 125/294 (42%), Gaps = 41/294 (13%)

Query: 75   AAKSNNLDLMEKLFEKKVNINVVNNMNR-TALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
            AA + ++ ++E L +K  +I   +   + T L  A        VD LL   A  +  +  
Sbjct: 1095 AATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVS 1154

Query: 134  GLTVIHLAAWSGSLEVMLMLVKAGAD--QRAKNQDGMSALHFATQSNHVRIVEYLIQDLH 191
              T + LAA  G + ++ +L+ AGA+   R  ++ G+S L  A  + HV  V+ L+ D+ 
Sbjct: 1155 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL-DMG 1213

Query: 192  LKDLNQPDEKGRKPFL-LAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA------- 243
              D+N   E  R   L LA  +G  E++  L     +   + K   + L  AA       
Sbjct: 1214 -SDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEV 1272

Query: 244  ------------LTKMKTSRNSIAALTI----------EGACSPGTGVSTSSVSLLQGGN 281
                           + +SR++  ALTI          E     G  +   +    + GN
Sbjct: 1273 GRVLLDKGADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIHRGAHIDVRN----KKGN 1326

Query: 282  TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 335
            T L LA+  GH   VQ+L+    D++  +   I+ L  A R GH  +V +L+ E
Sbjct: 1327 TPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 65/261 (24%), Positives = 110/261 (42%), Gaps = 19/261 (7%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKH 133
           AA   +++L   L E+  N+  VN+   T L  A    H   V  LL   A ++   ++ 
Sbjct: 445 AACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEET 504

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA-LHFATQSNHVRIVEYLIQDLHL 192
             T + LA   G  EV   L+KAGAD       G S  L  A+Q  H+ +V+YL+     
Sbjct: 505 QETALTLACCGGFSEVADFLIKAGADIEL----GCSTPLMEASQEGHLELVKYLLASG-- 558

Query: 193 KDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRN 252
            +++     G      A E GH ++ + L         + +           T +  +  
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESE--------GGRTPLMKAAR 610

Query: 253 SIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNEL 312
           +    T++   S G  V+ ++ +     +T + LA   GH   V++LLA   D     + 
Sbjct: 611 AGHLCTVQFLISKGANVNRATAN---NDHTVVSLACAGGHLAVVELLLAHGADPTHRLKD 667

Query: 313 NISSLQIATRNGHASLVNFLL 333
             + L  A + GH ++V++LL
Sbjct: 668 GSTMLIEAAKGGHTNVVSYLL 688



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 42/141 (29%), Positives = 74/141 (52%), Gaps = 13/141 (9%)

Query: 64   LLLPNERSFQNAAKSNNLDLMEK-----------LFEKKVNINV--VNNMNRTALHFAVG 110
            LLL  + + ++ AK+    LME            L +K  ++N   V +   TAL  A  
Sbjct: 1242 LLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301

Query: 111  RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA 170
            + H    + L+   A +DV +K G T + LA+  G  +V+ +LV+AGAD  A +   ++ 
Sbjct: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361

Query: 171  LHFATQSNHVRIVEYLIQDLH 191
            L  A +  HV++V+YL+++++
Sbjct: 1362 LMSAFRKGHVKVVQYLVKEVN 1382



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 63/248 (25%), Positives = 103/248 (41%), Gaps = 25/248 (10%)

Query: 75  AAKSNNLDLMEKLFEKKVNINV-VNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKH 133
           AA+  + +++  L  +  NIN        TAL  A         DFL+K  A +++    
Sbjct: 478 AAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS- 536

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLK 193
             T +  A+  G LE++  L+ +GA+  A    G +AL +A ++ H  + + L+Q     
Sbjct: 537 --TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG--A 592

Query: 194 DLNQPDEKGRKPFLLAAERGHV----EMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKT 249
           DL    E GR P + AA  GH+     +I K   +N  T+  D        T        
Sbjct: 593 DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDH-------TVVSLACAG 645

Query: 250 SRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEM 309
              ++  L +     P           L+ G+T L  AAK GH+  V  LL    ++  +
Sbjct: 646 GHLAVVELLLAHGADP--------THRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSV 697

Query: 310 NELNISSL 317
              ++S L
Sbjct: 698 PTTDVSQL 705



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/127 (27%), Positives = 59/127 (46%), Gaps = 1/127 (0%)

Query: 62  HELLLPNERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLL 121
           H      + +   A ++ + D+ + L +   ++   +   RT L  A    HL  V FL+
Sbjct: 562 HATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLI 621

Query: 122 KHKARVDVADKHG-LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHV 180
              A V+ A  +   TV+ LA   G L V+ +L+  GAD   + +DG + L  A +  H 
Sbjct: 622 SKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHT 681

Query: 181 RIVEYLI 187
            +V YL+
Sbjct: 682 NVVSYLL 688


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  106 bits (265), Expect = 5e-23
 Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)

Query: 70  RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
           RS   A    +++ + KL ++  ++N       + L  A    +      LL   A V D
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 266

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
             +K  +T +  A+  G L+++ +L+   AD  +++  G +AL +A     V IV+ L+ 
Sbjct: 267 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 326

Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
           +  +++D N   E G  P + AA  GHVE+   L      +N H++E             
Sbjct: 327 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 383

Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
             D +++  L   A  + KT     A +    AC  G  V  + + L  G          
Sbjct: 384 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 438

Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
            + L LAA  GH     +L+ +  ++ E+N+   + L  A R GH  +V  LL++  +++
Sbjct: 439 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498

Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
            Q  E +E+ L L        V + L+ A  DI++      TPL  A+  G++ELV+ LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 555

Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            +G ++ A    G TAL  A  + H+ V  +L++A
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 590



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 81/295 (27%), Positives = 126/295 (42%), Gaps = 19/295 (6%)

Query: 81  LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
           +D+++ L  +  NI   N    T L  A    H+     LL H A ++  +++   + + 
Sbjct: 318 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 377

Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
           LA + G L+++  L++AGADQ  K  +  +AL  A    HV +   L+       +N P 
Sbjct: 378 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 435

Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI 259
           +    P  LAA  GHVE+   L     +  E +   ++ L  AA    +     +A L  
Sbjct: 436 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA---REGHEEMVALLLA 492

Query: 260 EGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISS-LQ 318
           +GA        T          TAL LA   G S     L+    DI    EL  S+ L 
Sbjct: 493 QGANINAQTEETQE--------TALTLACCGGFSEVADFLIKAGADI----ELGCSTPLM 540

Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            A++ GH  LV +LL+   ++H      ++ L     N H  V + LL A  D+D
Sbjct: 541 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 62/283 (21%), Positives = 103/283 (36%), Gaps = 59/283 (20%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E +   A    +LD++  L E   +     +   TAL  A    H+     LL   A+V+
Sbjct: 373 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 432

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           +      + + LAA  G +E+  +L++ GA+    N +G +                   
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT------------------- 473

Query: 189 DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMK 248
                           P + AA  GH EM+  L                 L   A    +
Sbjct: 474 ----------------PLMEAAREGHEEMVALL-----------------LAQGANINAQ 500

Query: 249 TSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQW 303
           T      ALT+  AC  G       +  +   +  G +T L  A++ GH   V+ LLA  
Sbjct: 501 TEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG 558

Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPK 346
            +++       ++L  A  NGH  + + LL    DL ++ + K
Sbjct: 559 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 601


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  106 bits (265), Expect = 5e-23
 Identities = 104/395 (26%), Positives = 179/395 (45%), Gaps = 41/395 (10%)

Query: 70  RSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV-D 128
           RS   A    +++ + KL ++  ++N       + L  A    +      LL   A V D
Sbjct: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVED 255

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
             +K  +T +  A+  G L+++ +L+   AD  +++  G +AL +A     V IV+ L+ 
Sbjct: 256 RGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLN 315

Query: 189 D-LHLKDLNQPDEKGRKPFLLAAERGHVEMIEKL----TFLNLHTSE------------- 230
           +  +++D N   E G  P + AA  GHVE+   L      +N H++E             
Sbjct: 316 EGANIEDHN---ENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKG 372

Query: 231 -KDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGN-------- 281
             D +++  L   A  + KT     A +    AC  G  V  + + L  G          
Sbjct: 373 HLDMVRF-LLEAGADQEHKTDEMHTALME---ACMDGH-VEVARLLLDSGAQVNMPADSF 427

Query: 282 -TALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLH 340
            + L LAA  GH     +L+ +  ++ E+N+   + L  A R GH  +V  LL++  +++
Sbjct: 428 ESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 487

Query: 341 -QKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 399
            Q  E +E+ L L        V + L+ A  DI++      TPL  A+  G++ELV+ LL
Sbjct: 488 AQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLELVKYLL 544

Query: 400 KAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
            +G ++ A    G TAL  A  + H+ V  +L++A
Sbjct: 545 ASGANVHATTATGDTALTYACENGHTDVADVLLQA 579



 Score = 90.5 bits (223), Expect = 4e-18
 Identities = 81/295 (27%), Positives = 126/295 (42%), Gaps = 19/295 (6%)

Query: 81  LDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDV-ADKHGLTVIH 139
           +D+++ L  +  NI   N    T L  A    H+     LL H A ++  +++   + + 
Sbjct: 307 VDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALT 366

Query: 140 LAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPD 199
           LA + G L+++  L++AGADQ  K  +  +AL  A    HV +   L+       +N P 
Sbjct: 367 LACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG--AQVNMPA 424

Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTI 259
           +    P  LAA  GHVE+   L     +  E +   ++ L  AA    +     +A L  
Sbjct: 425 DSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAA---REGHEEMVALLLA 481

Query: 260 EGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISS-LQ 318
           +GA        T          TAL LA   G S     L+    DI    EL  S+ L 
Sbjct: 482 QGANINAQTEETQE--------TALTLACCGGFSEVADFLIKAGADI----ELGCSTPLM 529

Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDID 373
            A++ GH  LV +LL+   ++H      ++ L     N H  V + LL A  D+D
Sbjct: 530 EASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 62/283 (21%), Positives = 103/283 (36%), Gaps = 59/283 (20%)

Query: 69  ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVD 128
           E +   A    +LD++  L E   +     +   TAL  A    H+     LL   A+V+
Sbjct: 362 ESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVN 421

Query: 129 VADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ 188
           +      + + LAA  G +E+  +L++ GA+    N +G +                   
Sbjct: 422 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYT------------------- 462

Query: 189 DLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMK 248
                           P + AA  GH EM+  L                 L   A    +
Sbjct: 463 ----------------PLMEAAREGHEEMVALL-----------------LAQGANINAQ 489

Query: 249 TSRNSIAALTIEGACSPGTG-----VSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQW 303
           T      ALT+  AC  G       +  +   +  G +T L  A++ GH   V+ LLA  
Sbjct: 490 TEETQETALTL--ACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASG 547

Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPK 346
            +++       ++L  A  NGH  + + LL    DL ++ + K
Sbjct: 548 ANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK 590


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score =  105 bits (261), Expect = 2e-22
 Identities = 96/357 (26%), Positives = 148/357 (41%), Gaps = 60/357 (16%)

Query: 88  FEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSL 147
           + ++++IN +NN   T LH AV    L  +   L + A++D  +K   T IH AA  G+ 
Sbjct: 226 YSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGAT 285

Query: 148 EVMLMLVK--AGADQRAKNQDGM--SALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGR 203
           E++ +++   +G+       DG   + LH A+  +H  + +YLI      D+N+ D +GR
Sbjct: 286 EIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLIS--VGADINKIDSEGR 343

Query: 204 KPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGAC 263
            P +LA       ++  L         KD                               
Sbjct: 344 SPLILATASASWNIVNLLLSKGAQVDIKDNF----------------------------- 374

Query: 264 SPGTGVSTSSVSLLQGGNTALHLAAKHGHS-PAVQVLLAQWQDINE--MNELN--ISSLQ 318
                           G   LHL  +  +    ++    Q Q I E  M+E N   + L 
Sbjct: 375 ----------------GRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLH 418

Query: 319 IATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQK 378
            A R G    VN LL  NV +H K + K+SPLH       I     LL    D  +LN+ 
Sbjct: 419 YACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEG 478

Query: 379 Q---QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
                TPLH+AA  G+ ++V+ LLK G  L   D  G TAL  AS   ++  + +++
Sbjct: 479 DLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFLSDHNGWTALHHASMGGYTQTMKVIL 534



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 105/443 (23%), Positives = 179/443 (40%), Gaps = 73/443 (16%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKA-RVDVADKH 133
           A + N ++ ++ L  +  N N+ N      LH AV   +   +  LL+H+   V++  ++
Sbjct: 105 AVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGEN 164

Query: 134 GLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLI------ 187
           G T + +A  + + E + +L+K GA     N+ G   +H A  S     +E ++      
Sbjct: 165 GNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEH 224

Query: 188 ---QDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAAL 244
              + LH+  +N        P  LA + G +EMI+            +K + + +  AA 
Sbjct: 225 GYSRQLHINFMNNGK---ATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAA- 280

Query: 245 TKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQG-GNTALHLAAKHGHSPAVQVLLAQW 303
           T+  T    +   +  G        S   V+   G   T LH A+   H      L++  
Sbjct: 281 TQGATEIVKLMISSYSG--------SVDIVNTTDGCHETMLHRASLFDHHELADYLISVG 332

Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVD-----------LHQKVEP------- 345
            DIN+++    S L +AT +   ++VN LLS+              LH  V+        
Sbjct: 333 ADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNL 392

Query: 346 ----------KE----------SPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHV 385
                     KE          +PLH          VN+LL     I   ++ +++PLH 
Sbjct: 393 RPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHF 452

Query: 386 AADRGNVELVETLLKAGCDLKAV---DKQGKTALAVASRSNHSLVVGMLIKAERYY---- 438
           AA  G +   + LL+   D + +   D  G T L +A+++ H  VV +L+K    +    
Sbjct: 453 AASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDH 512

Query: 439 -AWREEHHESIRDPSTGFTLTFK 460
             W   HH S+     G+T T K
Sbjct: 513 NGWTALHHASM----GGYTQTMK 531



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 70/345 (20%), Positives = 149/345 (43%), Gaps = 11/345 (3%)

Query: 88  FEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKAR--VDVADKHGLTVIHLAAWSG 145
           F K+  +   ++M+   LH+A     +  ++ + +  +   +   D +G T +H A    
Sbjct: 50  FNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKN 109

Query: 146 SLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKP 205
            +E +  L+  GA+   +N + M+ LH A Q  +  +++ L++   + D+N   E G   
Sbjct: 110 QIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTI-DVNLEGENGNTA 168

Query: 206 FLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSP 265
            ++A    + E ++ L        + +K     +  AA +  K     I     E   S 
Sbjct: 169 VIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSR 228

Query: 266 GTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGH 325
              ++  +     G  T LHLA ++G    +++ L     I+ + +   +++  A   G 
Sbjct: 229 QLHINFMN----NGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGA 284

Query: 326 ASLVNFLLSE---NVDLHQKVEP-KESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQT 381
             +V  ++S    +VD+    +   E+ LH   + +H  + + L+S   DI+ ++ + ++
Sbjct: 285 TEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRS 344

Query: 382 PLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSL 426
           PL +A    +  +V  LL  G  +   D  G+  L +  +  + L
Sbjct: 345 PLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGL 389



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 83/357 (23%), Positives = 141/357 (39%), Gaps = 63/357 (17%)

Query: 68  NERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV 127
           +E     A+  ++ +L + L     +IN +++  R+ L  A      + V+ LL   A+V
Sbjct: 309 HETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQV 368

Query: 128 DV--------------------------------------ADKHGLTVIHLAAWSGSLEV 149
           D+                                       D  G T +H A   G    
Sbjct: 369 DIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGS 428

Query: 150 MLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDL-HLKDLNQPDEKGRKPFLL 208
           +  L+       +K++D  S LHFA     +   + L+QD+   + LN+ D  G  P  L
Sbjct: 429 VNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHL 488

Query: 209 AAERGHVEMIEKL-----TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGAC 263
           AA+ GH ++++ L      FL+ H        W+ L  A++     +   I    ++  C
Sbjct: 489 AAKNGHDKVVQLLLKKGALFLSDHNG------WTALHHASMGGYTQTMKVILDTNLK--C 540

Query: 264 SPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRN 323
           +           L + GNTALH AA+ GH+ AV +LL+   DI  +N+   S L +A  N
Sbjct: 541 TD---------RLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQASFLHLALHN 590

Query: 324 GHASLV-NFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ 379
               +V   + S+  D   K+    SP +   I   I  +   +    D  +L+  +
Sbjct: 591 KRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTE 647



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 30/96 (31%), Positives = 50/96 (52%), Gaps = 1/96 (1%)

Query: 339 LHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETL 398
           LH+  +   +PLH  V  N I  V  LLS   + ++ N     PLH+A    N E+++ L
Sbjct: 91  LHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVL 150

Query: 399 LK-AGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           L+    D+    + G TA+ +A  +N+S  + +L+K
Sbjct: 151 LEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  103 bits (257), Expect = 5e-22
 Identities = 95/373 (25%), Positives = 161/373 (43%), Gaps = 43/373 (11%)

Query: 83  LMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAA 142
           + E L  K  NIN       T LH A  + H   V+ ++KH+A+V+  D  G T +H AA
Sbjct: 382 ICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAA 441

Query: 143 WSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKG 202
           + G L+   +L+  G D    +  G +AL    ++         +Q L  + ++  + + 
Sbjct: 442 YCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNEN---------VQQLLQEGISLGNSEA 492

Query: 203 RKPFLLAAERGHVEMIEKL-TFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEG 261
            +  L AA+ G VE ++KL T  +++  + +  Q + L  AA        N ++   +E 
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAA------GYNRVSV--VEY 544

Query: 262 ACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIAT 321
               G  V        +GG   LH A  +GH    ++L+     +N  +    + L  A 
Sbjct: 545 LLQHGADVHAKD----KGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA 600

Query: 322 RNGHASLVNFLLSENVDLHQKVEPKESPLHLV---------VINNHITVVNSL------- 365
             G   +   LL    D  +K     +PL LV         ++     ++++        
Sbjct: 601 AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR 660

Query: 366 ---LSAQHDIDILNQ--KQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVAS 420
              LS+  +++  +   +  TPLH+AA   N+E+ E LL+ G D+ A DK G   L  A+
Sbjct: 661 VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA 720

Query: 421 RSNHSLVVGMLIK 433
              H  V  +LIK
Sbjct: 721 SYGHVDVAALLIK 733



 Score = 97.1 bits (240), Expect = 4e-20
 Identities = 108/408 (26%), Positives = 155/408 (37%), Gaps = 57/408 (13%)

Query: 73  QNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADK 132
           ++A   N   +M  L    VN +  +    T LH A G N +  V  LL+H A V   DK
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242

Query: 133 HGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQ---- 188
             L  +H A   G  EV  +LVK GA   A +    + LH A   N V +   L+     
Sbjct: 243 GDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGAD 302

Query: 189 ------------DL----HLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKD 232
                       DL     LK+    + KG    L AA    V  I+K   L +   +  
Sbjct: 303 PTLLNCHNKSAIDLAPTPQLKERLAYEFKGHS-LLQAAREADVTRIKKHLSLEMVNFKHP 361

Query: 233 KIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGH 292
           +   + L  AA +     R  I  L +      G  ++  +   L    T LH+A++  H
Sbjct: 362 QTHETALHCAAASPY-PKRKQICELLLR----KGANINEKTKEFL----TPLHVASEKAH 412

Query: 293 SPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVD-----------LHQ 341
           +  V+V++     +N ++ L  +SL  A   GH      LLS   D           L  
Sbjct: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQM 472

Query: 342 KVEPKESPLHLVVINNHITVVNSLLSAQHDIDI----------------LNQKQQTPLHV 385
             E  +  L   +   +      LL A    D+                +  +Q TPLH 
Sbjct: 473 GNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHF 532

Query: 386 AADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           AA    V +VE LL+ G D+ A DK G   L  A    H  V  +L+K
Sbjct: 533 AAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVK 580



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 85/322 (26%), Positives = 136/322 (42%), Gaps = 28/322 (8%)

Query: 69  ERSFQNAAKSNNLDLMEKLFE-KKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARV 127
           +R    AAK+ +++ ++KL   + VN   +     T LHFA G N +S V++LL+H A V
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552

Query: 128 DVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLI 187
              DK GL  +H A   G  EV  +LVK GA     +    + LH A       I + L+
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612

Query: 188 QDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKM 247
           Q  H  D  + +  G  P  L  + G  ++ + L        +   +  +     A  K 
Sbjct: 613 Q--HGADPTKKNRDGNTPLDLVKD-GDTDIQDLL------RGDAALLDAAKKGCLARVKK 663

Query: 248 KTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDIN 307
            +S +++     +G  S                 T LHLAA + +    + LL    D+N
Sbjct: 664 LSSPDNVNCRDTQGRHS-----------------TPLHLAAGYNNLEVAEYLLQHGADVN 706

Query: 308 EMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLS 367
             ++  +  L  A   GH  +   L+  N  ++   +   +PLH         +   LL+
Sbjct: 707 AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLA 766

Query: 368 AQHDIDILNQKQQTPLH-VAAD 388
              D  + NQ+ QTPL  V+AD
Sbjct: 767 HGADPTLKNQEGQTPLDLVSAD 788



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 90/396 (22%), Positives = 163/396 (41%), Gaps = 50/396 (12%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           A++  + D++E + + +  +N ++N+ +T+LH A    HL     LL +    ++    G
Sbjct: 407 ASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQG 466

Query: 135 LTVIHL--------------------------AAWSGSLEVMLMLVKAGADQRAKNQDGM 168
            T + +                          AA +G +E +  L    +    ++ +G 
Sbjct: 467 FTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQS-VNCRDIEGR 525

Query: 169 SA--LHFATQSNHVRIVEYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNL 226
            +  LHFA   N V +VEYL+Q  H  D++  D+ G  P   A   GH E+ E L     
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQ--HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGA 583

Query: 227 HTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSL---------- 276
             +  D  +++ L  AA       +  I  L ++    P       +  L          
Sbjct: 584 VVNVADLWKFTPLHEAAAK----GKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI 639

Query: 277 --LQGGNTALHLAAKHGHSPAVQVLLAQWQDIN--EMNELNISSLQIATRNGHASLVNFL 332
             L  G+ AL  AAK G    V+ L +   ++N  +    + + L +A    +  +  +L
Sbjct: 640 QDLLRGDAALLDAAKKGCLARVKKLSSP-DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYL 698

Query: 333 LSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNV 392
           L    D++ + +    PLH      H+ V   L+     ++  ++   TPLH AA +G  
Sbjct: 699 LQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRT 758

Query: 393 ELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVV 428
           +L   LL  G D    +++G+T L + S  + S ++
Sbjct: 759 QLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALL 794



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 107/422 (25%), Positives = 168/422 (39%), Gaps = 56/422 (13%)

Query: 58  AVAGHELLLPNERSFQNAAKSNNLDLMEKLFE-KKVNINVVNNMNRTALHFAVGRNHLSA 116
           A A  E + P  R    A ++ +++ +++L   +KVN         T LHFA G      
Sbjct: 14  ASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDV 73

Query: 117 VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQ 176
           V++LL++ A V   D  GL  +H A   G  EV+ +L++ GAD  A++    + LH A  
Sbjct: 74  VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAI 133

Query: 177 SNHVRIVEYLIQ-----------DLHLKDLNQPDEKG------RKPFLLAAERGHVE--M 217
              + +   L+Q                DL  P  K       +K  LL + R   E  M
Sbjct: 134 KGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKM 193

Query: 218 IEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLL 277
           +  LT LN++    D  + + L  AA      +R  I  L ++     G  V        
Sbjct: 194 MALLTPLNVNCHASDGRKSTPLHLAA----GYNRVKIVQLLLQ----HGADVHAKD---- 241

Query: 278 QGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENV 337
           +G    LH A  +GH    ++L+     +N M+    + L  A       + + LLS   
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301

Query: 338 D-----LHQKVEPKESPL-HLVVINNHITVVNSLLSAQHDIDILN--------------- 376
           D      H K     +P   L     +    +SLL A  + D+                 
Sbjct: 302 DPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHP 361

Query: 377 QKQQTPLHVAADR---GNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 433
           Q  +T LH AA        ++ E LL+ G ++    K+  T L VAS   H+ VV +++K
Sbjct: 362 QTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421

Query: 434 AE 435
            E
Sbjct: 422 HE 423



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 93/418 (22%), Positives = 163/418 (38%), Gaps = 82/418 (19%)

Query: 75  AAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHG 134
           AA  N + +++ L +   +++  +  +   LH A    H    + L+KH A V+  D   
Sbjct: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277

Query: 135 LTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSA----------------------LH 172
            T +H AA    +EV  +L+  GAD    N    SA                      L 
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337

Query: 173 FATQSNHVRIVEYL------------------------------IQDLHLK---DLNQPD 199
            A +++  RI ++L                              I +L L+   ++N+  
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397

Query: 200 EKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALT-KMKTSRNSIAALT 258
           ++   P  +A+E+ H +++E +       +  D +  ++L  AA    ++T R     L 
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR-----LL 452

Query: 259 IEGACSPGTGVSTSSVSLLQGGNTALHLAAKHG----HSPAVQVLL--AQWQDINEMNEL 312
           +   C P   +S    + LQ GN  +    + G    +S A + LL  A+  D+  + +L
Sbjct: 453 LSYGCDPNI-ISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKL 511

Query: 313 --------------NISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH 358
                           + L  A      S+V +LL    D+H K +    PLH      H
Sbjct: 512 CTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGH 571

Query: 359 ITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTAL 416
             V   L+     +++ +  + TPLH AA +G  E+ + LL+ G D    ++ G T L
Sbjct: 572 YEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPL 629



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 74/316 (23%), Positives = 126/316 (39%), Gaps = 23/316 (7%)

Query: 65  LLPNERSFQNAAKSNNLDLMEKLFEK-KVNINVVNNMNRTALHFAVGRNHLSAVDFLLKH 123
           LL  + +  +AAK   L  ++KL     VN       + T LH A G N+L   ++LL+H
Sbjct: 642 LLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQH 701

Query: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
            A V+  DK GL  +H AA  G ++V  +L+K  A   A ++   + LH A Q    ++ 
Sbjct: 702 GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLC 761

Query: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA 243
             L+   H  D    +++G+ P         ++++       L T+        + +   
Sbjct: 762 ALLL--AHGADPTLKNQEGQTP---------LDLVSADDVSALLTAAMPPSALPSCYKPQ 810

Query: 244 LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQW 303
           +     S  + A     G  SP +  + SS+  L G  + L        +     L    
Sbjct: 811 VLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSSGTEGASSL---- 866

Query: 304 QDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNH----- 358
            +  E+  ++ S  Q     G   L++    E + L   VE     L  + IN +     
Sbjct: 867 -EKKEVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHK 925

Query: 359 -ITVVNSLLSAQHDID 373
            I  V  L+S Q  ++
Sbjct: 926 LIKGVERLISGQQGLN 941



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 45/185 (24%), Positives = 81/185 (43%), Gaps = 3/185 (1%)

Query: 266 GTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISS--LQIATRN 323
           G   ++++   ++     L  A ++G    V+ L+   + +N  +     S  L  A   
Sbjct: 10  GAACASAAAEAVEPAARELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGF 68

Query: 324 GHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPL 383
           G   +V +LL    ++  + +    PLH      H  VVN LL    D +  +    TPL
Sbjct: 69  GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128

Query: 384 HVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKAERYYAWREE 443
           H AA +G +++   LL+ G +    +  G+TAL +A  S  +++ G   K E   + R  
Sbjct: 129 HEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSG 188

Query: 444 HHESI 448
           + E +
Sbjct: 189 NEEKM 193


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  102 bits (255), Expect = 8e-22
 Identities = 90/352 (25%), Positives = 141/352 (40%), Gaps = 54/352 (15%)

Query: 83  LMEKLFEKKVNINVVNNMNRTALHFAVGRNHLSAVDFLLKHKARVDVADKHGLTVIHLAA 142
           L+ +L  +  ++   ++  RT LH AV R H   V  LL+  A V   D+ G T +H AA
Sbjct: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115

Query: 143 WSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIVEYLIQDLHLKDLNQPDEKG 202
           W G   V  +L++ GA   A++  G++ LH+A    H  +   L++             G
Sbjct: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLE-----------APG 164

Query: 203 RKPFLLAAE--RGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAALTKMKTSRNSIAALTIE 260
             P    AE  RG                          WTAA       R ++  L   
Sbjct: 165 PGPAAAEAEDARG--------------------------WTAAHWAAAGGRLAVLELLAA 198

Query: 261 GACSPGTGVSTSSVSLLQGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIA 320
           G                 G + AL +AA  G   A++ LLA+   ++  +    ++L +A
Sbjct: 199 GGA---------------GLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA 243

Query: 321 TRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQ 380
              G +  +  LL    D   +     S LH      H+  V  L++   ++D  +    
Sbjct: 244 AALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGL 303

Query: 381 TPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 432
           TPLH A+  G+VE+   LL  G  + A     KT L +A+   H   VG+L+
Sbjct: 304 TPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLL 355



 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 35/115 (30%), Positives = 55/115 (47%)

Query: 320 ATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ 379
           A   G A LV  LL +   + ++     +PLHL V+  H  +V  LL     +  +++  
Sbjct: 48  AVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAG 107

Query: 380 QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIKA 434
           +T LH AA  G+  + E LL+ G    A    G T L  A+   H+L+   L++A
Sbjct: 108 RTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 45/175 (25%), Positives = 69/175 (39%), Gaps = 28/175 (16%)

Query: 11  GATAGGLLLRAAAAAKGLREDLWGAAALPWRSL--SRIPKREGLGEEDTAVAGH------ 62
           GA   G LL AAAA +G        AAL +     +R+  R+G G     +A        
Sbjct: 200 GAGLDGALLVAAAAGRG--------AALRFLLARGARVDARDGAGATALGLAAALGRSQD 251

Query: 63  -ELLLPN-----------ERSFQNAAKSNNLDLMEKLFEKKVNINVVNNMNRTALHFAVG 110
            E+LL +             +   AA   +L  ++ L  +   ++  + +  T LH A  
Sbjct: 252 IEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASR 311

Query: 111 RNHLSAVDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQ 165
             H+     LL   A+VD       T +HLAA  G    + +L+  GA    + Q
Sbjct: 312 EGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.131    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,860,176
Number of Sequences: 37866
Number of extensions: 906292
Number of successful extensions: 7561
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 356
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 2293
Number of HSP's gapped (non-prelim): 2540
length of query: 607
length of database: 18,247,518
effective HSP length: 108
effective length of query: 499
effective length of database: 14,157,990
effective search space: 7064837010
effective search space used: 7064837010
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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