Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 116284398

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116284398 WAS/WASL interacting protein family, member 1
[Homo sapiens]
         (503 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116284398 WAS/WASL interacting protein family, member 1 [Homo...  1084   0.0  
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ...  1084   0.0  
gi|18959210 WIRE protein [Homo sapiens]                               304   1e-82
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...   202   8e-52
gi|160707881 formin 2 [Homo sapiens]                                  152   9e-37
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]    151   1e-36
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...   135   1e-31
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...   127   2e-29
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...   119   8e-27
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]             119   8e-27
gi|47132519 Ras association and pleckstrin homology domains 1 is...   118   1e-26
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]                116   5e-26
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]     115   9e-26
gi|163965366 nascent polypeptide-associated complex alpha subuni...   115   9e-26
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   115   1e-25
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...   114   2e-25
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap...   114   3e-25
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa...   111   1e-24
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...   111   2e-24
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]         111   2e-24
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]         111   2e-24
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]         111   2e-24
gi|116284392 mucin 2 precursor [Homo sapiens]                         110   4e-24
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...   109   7e-24
gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]                108   9e-24
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                    104   2e-22
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                    104   2e-22
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...   104   2e-22
gi|239754955 PREDICTED: similar to COL22A1 protein [Homo sapiens]     103   5e-22
gi|19718731 bromodomain-containing protein 4 isoform long [Homo ...   103   5e-22

>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 1084 bits (2804), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILD 60
           MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILD
Sbjct: 1   MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILD 60

Query: 61  KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDND 120
           KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDND
Sbjct: 61  KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDND 120

Query: 121 SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180
           SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP
Sbjct: 121 SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180

Query: 181 DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL 240
           DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL
Sbjct: 181 DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL 240

Query: 241 SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300
           SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP
Sbjct: 241 SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300

Query: 301 SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360
           SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP
Sbjct: 301 SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360

Query: 361 PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420
           PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP
Sbjct: 361 PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420

Query: 421 DRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLA 480
           DRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLA
Sbjct: 421 DRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLA 480

Query: 481 RNESRSGSNRRERGAPPLPPIPR 503
           RNESRSGSNRRERGAPPLPPIPR
Sbjct: 481 RNESRSGSNRRERGAPPLPPIPR 503


>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
           sapiens]
          Length = 503

 Score = 1084 bits (2804), Expect = 0.0
 Identities = 503/503 (100%), Positives = 503/503 (100%)

Query: 1   MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILD 60
           MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILD
Sbjct: 1   MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILD 60

Query: 61  KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDND 120
           KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDND
Sbjct: 61  KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDND 120

Query: 121 SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180
           SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP
Sbjct: 121 SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180

Query: 181 DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL 240
           DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL
Sbjct: 181 DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL 240

Query: 241 SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300
           SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP
Sbjct: 241 SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300

Query: 301 SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360
           SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP
Sbjct: 301 SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360

Query: 361 PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420
           PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP
Sbjct: 361 PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420

Query: 421 DRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLA 480
           DRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLA
Sbjct: 421 DRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLA 480

Query: 481 RNESRSGSNRRERGAPPLPPIPR 503
           RNESRSGSNRRERGAPPLPPIPR
Sbjct: 481 RNESRSGSNRRERGAPPLPPIPR 503


>gi|18959210 WIRE protein [Homo sapiens]
          Length = 440

 Score =  304 bits (779), Expect = 1e-82
 Identities = 210/519 (40%), Positives = 251/519 (48%), Gaps = 101/519 (19%)

Query: 2   PVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKK-TVTNDRSAPILD 60
           P PPPP PPPPPTF  ANTE+P L++ EQ GR ALL DI KG KLKK T  NDRSAPIL+
Sbjct: 6   PPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSAPILE 65

Query: 61  KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDND 120
           KPKG+            GG+G GG                GGLFQ G+ KLR    +D  
Sbjct: 66  KPKGSS-----------GGYGSGGAA----------LQPKGGLFQGGVLKLRPVGAKDGS 104

Query: 121 SG-GSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
                +P L  P  R+ + +P    +  GR    +   R+  PE  R + P       S 
Sbjct: 105 ENLAGKPALQIPSSRAAAPRP-PVSAASGRPQDDTDSSRASLPELPRMQRP-------SL 156

Query: 180 PDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSP 239
           PD   P   S+        H+  +PP P   R+ +  PTP P   ++  A          
Sbjct: 157 PDLSRPNTTSST----GMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPA---------- 202

Query: 240 LSSSSPFSNRPPLPPTPSRALDD--KPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPST 297
                 ++   PLPPTP + L    + PP PPPV           PPP P N +      
Sbjct: 203 ------YNREKPLPPTPGQRLHPGREGPPAPPPVK----------PPPSPVNIRTG---- 242

Query: 298 PRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPL 357
             PS  S APPPPP    PG P   PSS  N+  P LPQR+ SL   TP    P R G  
Sbjct: 243 --PSGQSLAPPPPPYRQPPGVPN-GPSSPTNESAPELPQRHNSLHRKTP---GPVR-GLA 295

Query: 358 PPPP--------SERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDS 409
           PPPP        S RPPPP RDPP R    PPPPPV RNG  +R  P  P  P R     
Sbjct: 296 PPPPTSASPSLLSNRPPPPARDPPSRGAAPPPPPPVIRNG--ARDAPPPPP-PYRMHGSE 352

Query: 410 PRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCE-----DEWESRFYFHPISDLPP 464
           P S  +PP PP R  AG PPPPPP   +RNG +DS        D++ES++ FHP+ D P 
Sbjct: 353 PPSRGKPPPPPSRTPAGPPPPPPP--PLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPA 410

Query: 465 PEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR 503
           PE Y    + YPSK         +NR  RGAPPLPPI R
Sbjct: 411 PEEYKHFQRIYPSK---------TNRAARGAPPLPPILR 440



 Score =  212 bits (540), Expect = 6e-55
 Identities = 173/484 (35%), Positives = 213/484 (44%), Gaps = 99/484 (20%)

Query: 1   MPVPPP----PAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKK-TVTNDRS 55
           MP+PPP    P PPPPPTF  ANTE+P L++ EQ GR ALL DI KG KLKK T  NDRS
Sbjct: 1   MPIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRS 60

Query: 56  APILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTA 115
           APIL+KPKG+      GG+G                 GG      GGLFQ G+ KLR   
Sbjct: 61  APILEKPKGS-----SGGYGS----------------GGAALQPKGGLFQGGVLKLRPVG 99

Query: 116 NRD-NDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPP--- 171
            +D +++   +P L  P  R+ + +P    +  GR    +   R+  PE  R + P    
Sbjct: 100 AKDGSENLAGKPALQIPSSRAAAPRP-PVSAASGRPQDDTDSSRASLPELPRMQRPSLPD 158

Query: 172 -PRPDVGSK-----PDSIPPP--------VPSTPRPIQSS---PHNRGS--PPVPG---- 208
             RP+  S        S PPP         P TP P+ SS    +NR    PP PG    
Sbjct: 159 LSRPNTTSSTGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLH 218

Query: 209 ----GPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKP 264
               GP  P P   PPP P N  T   G S+   P     P+   P +P  PS   ++  
Sbjct: 219 PGREGPPAPPP-VKPPPSPVNIRTGPSGQSLAPPP----PPYRQPPGVPNGPSSPTNESA 273

Query: 265 PPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPP--PPPSRPGPPPLP 322
           P  P       S+HR+   P P +   PP P++  PS  S  PPPP   PPSR   PP P
Sbjct: 274 PELPQ---RHNSLHRKT--PGPVRGLAPPPPTSASPSLLSNRPPPPARDPPSRGAAPPPP 328

Query: 323 PSSSGNDETPRLPQRNLSLSSSTPPLPSPGR-SGPLPPPPSERPPPPVRDPPGRSGPLPP 381
           P    N             +   PP P P R  G  PP   + PPPP R P   +GP PP
Sbjct: 329 PPVIRNG------------ARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTP---AGPPPP 373

Query: 382 PPPVSRNG---STSRALPATPQLPSRSGVDSPRSGPRP----------PLPPDRPSAGAP 428
           PPP  RNG   S +          S+         P P          P   +R + GAP
Sbjct: 374 PPPPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAPEEYKHFQRIYPSKTNRAARGAP 433

Query: 429 PPPP 432
           P PP
Sbjct: 434 PLPP 437



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 57/218 (26%), Positives = 80/218 (36%), Gaps = 31/218 (14%)

Query: 307 PPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPP 366
           P PPPPP  PGPPP P     N E P+L +       +       G         ++R  
Sbjct: 2   PIPPPPPPPPGPPPPPTFHQANTEQPKLSRDEQRGRGALLQDICKGTKLKKVTNINDRSA 61

Query: 367 PPVRDPPGRSG-------PLPPP------------PPVSRNGSTSRALPATPQLPSRSGV 407
           P +  P G SG        L P             P  +++GS + A     Q+PS    
Sbjct: 62  PILEKPKGSSGGYGSGGAALQPKGGLFQGGVLKLRPVGAKDGSENLAGKPALQIPS---- 117

Query: 408 DSPRSGPRPPL------PPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISD 461
            S  + PRPP+      P D   +     P      R    D    +   S    H  S 
Sbjct: 118 -SRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGMKHS-SS 175

Query: 462 LPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLP 499
            PPP P  +   + P+ L  + S++ +  RE+  PP P
Sbjct: 176 APPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTP 213


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score =  202 bits (513), Expect = 8e-52
 Identities = 168/515 (32%), Positives = 223/515 (43%), Gaps = 103/515 (20%)

Query: 1   MPVPPPPA---PPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKK-TVTNDRSA 56
           +P PPPP    PPPPP+    +T+  +L + +  GR+ALL+DI +G +L+K T  NDRSA
Sbjct: 11  LPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQINDRSA 70

Query: 57  PILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTAN 116
           P ++  KG                    GGG   + G   PP LG LF  G P LR    
Sbjct: 71  PQIESSKGTNK----------------EGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQ 114

Query: 117 RDNDSG------GSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGH---RSGPPEPQRN 167
           RD   G      GSR P  P     T + P  PP+ P R    S  H   R+ PP P   
Sbjct: 115 RDVAGGKTGQGPGSRAP-SPRLPNKTISGPLIPPASP-RLGNTSEAHGAARTAPPRPNVP 172

Query: 168 RMPPPRPDVGSKPDSIPPPVPS-----TPRPIQSSPHNRG-----SPPVPGGPRQPSPGP 217
             PPP P     P  +PPP+PS     TP      P  +G     +PPVP  P  P P P
Sbjct: 173 APPPPTPP--PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAP--PPPPP 228

Query: 218 TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPP--PPVGNRP 275
            PPP P               PL  +S  S++   P      L   PPP P  PP G  P
Sbjct: 229 PPPPTP--------------PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCG-YP 273

Query: 276 SIHREAVPPPPPQN-NKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL 334
            +  +A P  P Q+  +PP P  P P  +S +P    P      PPLP  +S ++  P L
Sbjct: 274 GL--KAEPASPAQDAQEPPAPPPPLPPYASCSPRASLP-----APPLPGVNSSSETPPPL 326

Query: 335 PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGP-----LPPPPPVSRNG 389
           P +  S S   PP  +  ++ P PP P    P   +   GR G       PPP P +R+ 
Sbjct: 327 PPK--SPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGGKLNPPPAPPARSP 384

Query: 390 STSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDE 449
           +T        +L S+S                + +    P   P   +RNG       D+
Sbjct: 385 TT--------ELSSKS----------------QQATAWTPTQQPGGQLRNG--SLHIIDD 418

Query: 450 WESRFYFHPISDLPPPEPYVQTTKSYPSKLARNES 484
           +ES+F FH + D PPP+ Y    K YPSK+ R+ +
Sbjct: 419 FESKFTFHSVEDFPPPDEYKPCQKIYPSKIPRSRT 453



 Score =  102 bits (255), Expect = 6e-22
 Identities = 122/423 (28%), Positives = 153/423 (36%), Gaps = 106/423 (25%)

Query: 140 PFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSP- 198
           P  PP  P   P+P P    G P P     PP   D  S   + P    +    IQ    
Sbjct: 2   PVPPPPPP---PLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTR 58

Query: 199 -------HNRGSPPVP--------GGPRQPSPGPTPPP---------FP-----GNRGTA 229
                  ++R +P +         GG    + G + PP         FP     G R  A
Sbjct: 59  LRKVTQINDRSAPQIESSKGTNKEGGGSANTRGASTPPTLGDLFAGGFPVLRPAGQRDVA 118

Query: 230 LGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKP-PPPPPPVGNRPSIHREAVPPPPPQ 288
             GG   Q P        +R P P  P++ +     PP  P +GN    H  A   PP  
Sbjct: 119 --GGKTGQGP-------GSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPP-- 167

Query: 289 NNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPP--SSSGNDETPRL----PQRNLSLS 342
             +P VP          APPPP PP  P PPPLPP   SS   +TP +    P    +L 
Sbjct: 168 --RPNVP----------APPPPTPP--PPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLP 213

Query: 343 SSTPPLPSPGRSGPLPPPPSERPPPPV----------RDPPGRSGPLPPP----PPVSRN 388
              PP+P      P PPPP+  P PP           +  P    P+PPP    PP    
Sbjct: 214 VVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYP 273

Query: 389 G-STSRALPA---------TPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIR 438
           G     A PA          P LP  +      S P PPLP    S+  PPP PP +   
Sbjct: 274 GLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSP-- 331

Query: 439 NGFQDSPCEDEWESRFYFHPISDLP-PPEPYVQTTKSYPSKLARNESRSGSNRRERGAPP 497
             FQ  P +   ++         LP PP P      S P    +   R G+   +   PP
Sbjct: 332 -SFQAPPQKAGAQA---------LPAPPAP----PGSQPFLQKKRHGRPGAGGGKLNPPP 377

Query: 498 LPP 500
            PP
Sbjct: 378 APP 380


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score =  152 bits (383), Expect = 9e-37
 Identities = 141/451 (31%), Positives = 172/451 (38%), Gaps = 94/451 (20%)

Query: 88   GGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF------ 141
            G G  G   P  +   FQ       S+A +++ +  S PPL  P   S+S+ P       
Sbjct: 821  GQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPL--PCTESSSSMPGLGMVPP 878

Query: 142  SPPSGPGRF--PVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTP-RPIQSSP 198
             PP  PG     +PS      PP      +PPP P +       PPP+P     P+    
Sbjct: 879  PPPPLPGMTVPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPL---- 934

Query: 199  HNRGSPPVPGG---PRQPSPG---PTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPL 252
                 PP+PG    P  P PG   P PPP PG              PL    P +  PP 
Sbjct: 935  -----PPLPGAGIPPPPPLPGAAIPPPPPLPG-----------AGIPLPPPLPGAGIPPP 978

Query: 253  PPTPSRALDDKPPPPPPP---VGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP 309
            PP P   +   PPPPP P   +   P +    +PPPPP       P  P P A    PPP
Sbjct: 979  PPLPGAGI---PPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1035

Query: 310  ------PPPPSRPG---PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360
                  PPPP  PG   PPP P   +G    P LP   +      PPLP  G   P P P
Sbjct: 1036 LPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGI---PPPPPLPGAGIPPPPPLP 1092

Query: 361  PSERPPPP------VRDPPGRSGP-LPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSG 413
             +  PPPP      +  PP   G  +PPPPP+   G     +P  P LP  +G+  P   
Sbjct: 1093 GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPLPGAG-----IPPPPPLPG-AGIPPPPPL 1146

Query: 414  PRP--PLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQT 471
            PR   P PP  P AG PPPPP                         P + +PPP P    
Sbjct: 1147 PRVGIPPPPPLPGAGIPPPPP------------------------LPGAGIPPPPPLPGV 1182

Query: 472  TKSYPSKLARNESRSGSNRRERGAPPLPPIP 502
                P  L              G PP PP+P
Sbjct: 1183 GIPPPPPLPGVGIPPPPPLPGAGIPPPPPLP 1213



 Score =  150 bits (380), Expect = 2e-36
 Identities = 129/377 (34%), Positives = 151/377 (40%), Gaps = 62/377 (16%)

Query: 97   PPGLGGLFQAGMPKLRSTANRDND--SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS 154
            PP L G+    +P L STA        G    P  PP        P  P  G G  P+P 
Sbjct: 880  PPPLPGMT---VPTLPSTAIPQPPPLQGTEMLPPPPPPLPGAGIPPPPPLPGAGILPLPP 936

Query: 155  -PGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRG---SPPVPGG- 209
             PG    PP P      PP P +      +PPP+P    P        G    PP+PG  
Sbjct: 937  LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996

Query: 210  --PRQPSPG---PTPPPFPGNR---GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALD 261
              P  P PG   P PPP PG        L G  I   P     P +  PP PP P   + 
Sbjct: 997  IPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP---PLPGAGIPPPPPLPGAGIP 1053

Query: 262  DKPP------PPPPPVGNR-----PSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP- 309
              PP      PPPPP+        P +    +PPPPP       P  P P      PPP 
Sbjct: 1054 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPL 1113

Query: 310  -----PPPPSRPG---PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP 361
                 PPPP  PG   PPP P   +G    P LP+  +      PPLP  G   P P P 
Sbjct: 1114 PGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIP---PPPPLPGAGIPPPPPLPG 1170

Query: 362  SERPPPP------VRDPPGRSGP-LPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGP 414
            +  PPPP      +  PP   G  +PPPPP+   G     +P  P LP   G+  P + P
Sbjct: 1171 AGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAG-----IPPPPPLP---GMGIPPA-P 1221

Query: 415  RPPLPPDRPSAGAPPPP 431
             PPLPP  P  G PPPP
Sbjct: 1222 APPLPP--PGTGIPPPP 1236



 Score =  144 bits (363), Expect = 2e-34
 Identities = 131/411 (31%), Positives = 154/411 (37%), Gaps = 110/411 (26%)

Query: 121  SGGSRPPLLPPGGRSTSAKPFSPPSGPGRF--------PVPSPGHRSGPPEPQRNRMPPP 172
            +G  +P   PP   ST  +     S    F        P P P   S    P    +PPP
Sbjct: 820  AGQGQPGSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSPPPLPCTESSSSMPGLGMVPPP 879

Query: 173  RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPG---PTPPPFPGNRGTA 229
             P +   P    P +PST  P    P  +G+  +P  P  P PG   P PPP PG     
Sbjct: 880  PPPL---PGMTVPTLPSTAIP--QPPPLQGTEMLPPPP-PPLPGAGIPPPPPLPG----- 928

Query: 230  LGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPP---VGNRPSIHREAVPPPP 286
               G +   PL    P +  PP PP P  A+   PPPPP P   +   P +    +PPPP
Sbjct: 929  --AGILPLPPL----PGAGIPPPPPLPGAAI---PPPPPLPGAGIPLPPPLPGAGIPPPP 979

Query: 287  PQNNKPPVPSTPRPSASSQAPPP------PPPPSRPG---PPPLPPSSSGNDETPRLPQR 337
            P       P  P P A    PPP      PPPP  PG   PPP P   +G    P LP  
Sbjct: 980  PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGA 1039

Query: 338  NLSLSSSTPPLPSPGRSGPLPPP-PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALP 396
             +      PP P PG   P PPP P    PPP   PP     +PPPPP+   G     +P
Sbjct: 1040 GIP-----PPPPLPGAGIPPPPPLPGAGIPPP---PPLPGAGIPPPPPLPGAG-----IP 1086

Query: 397  ATPQLPSRSGVDSPRSGPRP----PLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWES 452
              P LP   G   P   P P    P PP  P AG PPPPP                    
Sbjct: 1087 PPPPLP---GAGIPPPPPLPGVGIPPPPPLPGAGIPPPPPL------------------- 1124

Query: 453  RFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIPR 503
                 P + +PPP P                          G PP PP+PR
Sbjct: 1125 -----PGAGIPPPPPLPGA----------------------GIPPPPPLPR 1148



 Score =  128 bits (322), Expect = 1e-29
 Identities = 113/340 (33%), Positives = 137/340 (40%), Gaps = 57/340 (16%)

Query: 122  GGSRPPLLPPGGRSTSAKPFSPPSG-PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180
            G   PP  P  G      P  P +G P   P+P  G    PP P    +PPP P  G+  
Sbjct: 972  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG-IPPPPPLPGA-- 1028

Query: 181  DSIPPPVPSTPRPIQSSPHNRGS-----PPVPGG---PRQPSPG---PTPPPFPGNR--- 226
              IPPP P     I   P   G+     PP+PG    P  P PG   P PPP PG     
Sbjct: 1029 -GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPP 1087

Query: 227  GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP------PPPPPVGNR-----P 275
               L G  I   P     P    PP PP P   +   PP      PPPPP+        P
Sbjct: 1088 PPPLPGAGIPPPP---PLPGVGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP 1144

Query: 276  SIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             + R  +PPPPP       P  P P A    PPPPP P    PPP P    G    P LP
Sbjct: 1145 PLPRVGIPPPPPLPGAGIPPPPPLPGAG--IPPPPPLPGVGIPPPPPLPGVGIPPPPPLP 1202

Query: 336  QRNLSLSSSTPPLPS----PGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGST 391
               +      PPLP     P  + PLPPP +  PPPP+        P+  PP + + GS+
Sbjct: 1203 GAGI---PPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLL-------PVSGPPLLPQVGSS 1252

Query: 392  SRALPAT-----PQLPS---RSGVDSPRSGPRPPLPPDRP 423
            +   P       P LPS     G++  +   + P+ P RP
Sbjct: 1253 TLPTPQVCGFLPPPLPSGLFGLGMNQDKGSRKQPIEPCRP 1292



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 86/326 (26%), Positives = 108/326 (33%), Gaps = 88/326 (26%)

Query: 234  SIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPP 293
            SI+ SP       +    LPP     +D  P  PP P G       E+ P     +    
Sbjct: 743  SIQTSPTEEGGVLT----LPP-----VDGLPGRPPCPPG------AESGPQTKFCSEISL 787

Query: 294  VPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSST-------- 345
            + S  R S    +  P    S+P PPP    S+G  +    P  ++S    T        
Sbjct: 788  IVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQPGSQPPHSISTEFQTSHEHSVSS 847

Query: 346  -----------PPLPSPGRS------GPLPPPPSERP--------------PPPVR---- 370
                       PPLP    S      G +PPPP   P              PPP++    
Sbjct: 848  AFKNSCNIPSPPPLPCTESSSSMPGLGMVPPPPPPLPGMTVPTLPSTAIPQPPPLQGTEM 907

Query: 371  ----DPPGRSGPLPPPPPVSRNG------STSRALPATPQLPSRSGVDSPRSGPRP---- 416
                 PP     +PPPPP+   G           +P  P LP   G   P   P P    
Sbjct: 908  LPPPPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLP---GAAIPPPPPLPGAGI 964

Query: 417  PLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYP 476
            PLPP  P AG PPPPP   +   G    P            P + +PPP P        P
Sbjct: 965  PLPPPLPGAGIPPPPPLPGA---GIPPPPP----------LPGAGIPPPPPLPGAGIPPP 1011

Query: 477  SKLARNESRSGSNRRERGAPPLPPIP 502
              L              G PP PP+P
Sbjct: 1012 PPLPGAGIPPPPPLPGAGIPPPPPLP 1037



 Score = 36.6 bits (83), Expect = 0.055
 Identities = 98/429 (22%), Positives = 131/429 (30%), Gaps = 99/429 (23%)

Query: 68  GGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPP 127
           G GG    G  G GGGGGGGGG S              + + ++R   ++   +GGSR  
Sbjct: 38  GSGGKKALGKHGKGGGGGGGGGESGKKKSKSDSRASVFSNL-RIRKNLSKGKGAGGSRED 96

Query: 128 LLPPGGRSTS-----------------------------AKPF--SPPSGPGRFPVPSPG 156
           +L      T                              A PF  + P GPG    P+  
Sbjct: 97  VLDSQALQTGELDSAHSLLTKTPDLSLSADEAGLSDTECADPFEVTGPGGPG----PAEA 152

Query: 157 HRSGPP-----EPQRNRMPPPRPDVGSKPD---------------SIPPPV---PSTPRP 193
              G P     E         R   GS  D                I   +       + 
Sbjct: 153 RVGGRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLLSDIQQAIRLQQQQQQQ 212

Query: 194 IQSSPHNRGSPPVPGGPRQPSPGPTP-PPFPGN--------RGTALGGGSIRQSPLSSSS 244
           +Q     +       G  +P+  PT   P PG          G + G G    SP  +  
Sbjct: 213 LQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSGGAGEAPGSP-DTEQ 271

Query: 245 PFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVP-PPPPQNNKPPVPSTPRPSAS 303
             S    LP   S A + + P  PP  G  P     ++P   P   + P   + P P A 
Sbjct: 272 ALSALSDLP--ESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAG 329

Query: 304 SQAPPPPPPPSRPGP----------PPLPPSSSGNDETPRL----PQRNLSLSSSTPPLP 349
                   P    G              P  S G +  P +    PQR           P
Sbjct: 330 PGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEPEEEAQGP 389

Query: 350 SPGRSGPLP--PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGV 407
               +  LP  P PS+R   P         PL  P  +    +T+R L +    PS+S  
Sbjct: 390 DAPAAASLPGSPAPSQRCFKPY--------PLITPCYIK---TTTRQLSSPNHSPSQSPN 438

Query: 408 DSPRSGPRP 416
            SPR   RP
Sbjct: 439 QSPRIKRRP 447



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 60/251 (23%), Positives = 80/251 (31%), Gaps = 49/251 (19%)

Query: 123 GSRPPLLPPGGRSTSAKPFSPPSGPGRFPV-PSPGHRSGPPEPQRN-------------- 167
           G+  P  PP   S     F    G  RF + PS G    P  P                 
Sbjct: 228 GAEEPAAPPTAVSPQPGAFL---GLDRFLLGPSGGAGEAPGSPDTEQALSALSDLPESLA 284

Query: 168 ---RMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG 224
              R P   P  G  P S  P +P+     + SP +   P    GP + + G        
Sbjct: 285 AEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAG-------- 336

Query: 225 NRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPP 284
                 G G   +        F + P   P    A  +     P  +G  P    EA  P
Sbjct: 337 --APVRGAGDTDEE--GEEDAFEDAPRGSPGEEWA-PEVGEDAPQRLGEEP--EEEAQGP 389

Query: 285 PPPQNNKPPVPSTPRPSASSQAPPPPPPP-------SRPGPPPLPPSSSGNDETPRL--- 334
             P      +P +P PS     P P   P        +   P   PS S N ++PR+   
Sbjct: 390 DAPA--AASLPGSPAPSQRCFKPYPLITPCYIKTTTRQLSSPNHSPSQSPN-QSPRIKRR 446

Query: 335 PQRNLSLSSST 345
           P+ +LS  S T
Sbjct: 447 PEPSLSRGSRT 457


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score =  151 bits (382), Expect = 1e-36
 Identities = 134/425 (31%), Positives = 167/425 (39%), Gaps = 53/425 (12%)

Query: 35  ALLSDISKGKKLKKTVTNDRSAPIL-DKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFG 93
           ALL+ +S  + L + V+ + S  ++   P+GA   GG    G     G   G    G   
Sbjct: 9   ALLA-LSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGPPPQGGNQ 67

Query: 94  GGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGR--------STSAKPFSPPS 145
             GPP   G  Q   P+           GG++P   PP G+          S  P SPP 
Sbjct: 68  PQGPPPPPGKPQGPPPQ-----------GGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPG 116

Query: 146 GPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPP 205
            P   P        GPP P      PP P  G+KP   PPP      P Q    +R S  
Sbjct: 117 KPQGPPPQGGNQPQGPPPPPGKPQGPP-PQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRS 175

Query: 206 VPGGPRQPSP-------GPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPS- 257
            PG P+ P P       GP PPP    +G    GG+  Q P     P    PP     S 
Sbjct: 176 PPGKPQGPPPQGGNQPQGPPPPP-GKPQGPPPQGGNKPQGPPPPGKP-QGPPPQGDNKSQ 233

Query: 258 --RALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSR 315
             R+   KP  PPP  GN+P       PPPPP       P  P P   ++   PPPP   
Sbjct: 234 SARSPPGKPQGPPPQGGNQPQ-----GPPPPPGK-----PQGPPPQGGNKPQGPPPPGKP 283

Query: 316 PGPPPLPPSSSGNDET-PRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPG 374
            GPPP   S S +  + P  PQ       + P  P P    P  PPP     P    PPG
Sbjct: 284 QGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPG 343

Query: 375 RSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP----PLPPDRPSAGAP-- 428
           +  P  PPP       ++R+ P  PQ P +   ++P+  P P    P  P  P AG P  
Sbjct: 344 K--PQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQG 401

Query: 429 PPPPP 433
           PP PP
Sbjct: 402 PPRPP 406



 Score =  142 bits (357), Expect = 9e-34
 Identities = 123/381 (32%), Positives = 149/381 (39%), Gaps = 61/381 (16%)

Query: 103 LFQAGMPKLRSTANRDNDSGGSRPPLL--------PPGGRSTSAKPFSPPSGPGR--FPV 152
           L    +  L S  N + D      P L        PP G +   KP  PPS PG+   P 
Sbjct: 5   LLSVALLALSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGN---KPQGPPSPPGKPQGPP 61

Query: 153 PSPGHR-SGPPEPQRNRMPPPRPDVGSKPDSIPPP-VPSTPRP------IQSSPHNRGSP 204
           P  G++  GPP P      PP P  G+KP   PPP  P  P P         SP  +   
Sbjct: 62  PQGGNQPQGPPPPPGKPQGPP-PQGGNKPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQG 120

Query: 205 PVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPP-------TPS 257
           P P G  QP   P PP  P  +G    GG+  Q P     P   +P  PP         S
Sbjct: 121 PPPQGGNQPQGPPPPPGKP--QGPPPQGGNKPQGP-----PPPGKPQGPPPQGDNKSRSS 173

Query: 258 RALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPG 317
           R+   KP  PPP  GN+P       PPPPP       P  P P   ++   PPPP    G
Sbjct: 174 RSPPGKPQGPPPQGGNQPQ-----GPPPPPGK-----PQGPPPQGGNKPQGPPPPGKPQG 223

Query: 318 PPPLPPSSSGNDET-PRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRS 376
           PPP   + S +  + P  PQ       + P  P P    P  PPP     P    PPG+ 
Sbjct: 224 PPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGK- 282

Query: 377 GPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRP-------SAGAPP 429
            P  PPP       +SR+ P  PQ P   G + P+  P PP  P  P         G PP
Sbjct: 283 -PQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPP 341

Query: 430 P-----PPPSTSIRNGFQDSP 445
           P     PPP    ++    SP
Sbjct: 342 PGKPQGPPPQGGSKSRSARSP 362



 Score =  124 bits (312), Expect = 2e-28
 Identities = 119/390 (30%), Positives = 151/390 (38%), Gaps = 58/390 (14%)

Query: 4   PPPPAPP--PPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDK 61
           PPPP  P  PPP         P   K +            +G K +    + RS P   K
Sbjct: 72  PPPPGKPQGPPPQGGNKPQGPPPPGKPQ--------GPPPQGDKSR----SPRSPP--GK 117

Query: 62  PKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDS 121
           P+G    GG    G     G   G    G     GPP  G     G P      +R + S
Sbjct: 118 PQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGK--PQGPPPQGDNKSRSSRS 175

Query: 122 GGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHR-SGPPEPQRNRMPPPRPDVGSKP 180
              +P   PP G +    P  PP G  + P P  G++  GPP P + + PPP+ D  S+ 
Sbjct: 176 PPGKPQGPPPQGGNQPQGP-PPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQS 234

Query: 181 DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSP----GPTPPPFPGN-RGTALGGGSI 235
              PP  P  P P Q     +G PP PG P+ P P     P  PP PG  +G    GGS 
Sbjct: 235 ARSPPGKPQGPPP-QGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGSK 293

Query: 236 RQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVP 295
            +S                  SR+   KP  PPP  GN+P       PPPPP       P
Sbjct: 294 SRS------------------SRSPPGKPQGPPPQGGNQPQ-----GPPPPPGK-----P 325

Query: 296 STPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDET----PRLPQRNLSLSSSTPPLPSP 351
             P P   ++   PPPP    GPPP   S S +  +    P+ P +    +   PP P+ 
Sbjct: 326 QGPPPQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAG 385

Query: 352 GRSGPLPPPPSERPPPPVRDPPGRSGPLPP 381
           G       PP+ +P  P R P G     PP
Sbjct: 386 GNPQQPQAPPAGQPQGPPRPPQGGRPSRPP 415


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
           preproprotein [Homo sapiens]
          Length = 331

 Score =  135 bits (339), Expect = 1e-31
 Identities = 114/362 (31%), Positives = 138/362 (38%), Gaps = 68/362 (18%)

Query: 103 LFQAGMPKLRSTANRDNDSGGSRPPLL---------PPGGRSTSAKPFSPPSGPGRFPVP 153
           L    +  L S  N + D      P L         P GG      P  PP G  + P P
Sbjct: 5   LLSVALLALSSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGPP--PPPGKPQGPPP 62

Query: 154 SPGHR-SGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQ 212
             G++  GPP P + + PPP+ D    P S PP  P  P P Q     +G PP PG P+ 
Sbjct: 63  QGGNKPQGPPPPGKPQGPPPQGDKSRSPRS-PPGKPQGPPP-QGGNQPQGPPPPPGKPQG 120

Query: 213 PSPG----PTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPP 268
           P P     P  PP PG        G   +SP S           PP        KP  PP
Sbjct: 121 PPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRS-----------PP-------GKPQGPP 162

Query: 269 PPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRP-GPPPLPPSSSG 327
           P  GN+P       PPPPP   KP  P    P    + P  PPPP +P GPPP    S  
Sbjct: 163 PQGGNQPQ-----GPPPPP--GKPQGP----PPQGGKKPQGPPPPGKPQGPPPQGDKSRS 211

Query: 328 NDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSR 387
           +   P  PQ       + P  P P    P  PPP     P    PPG+  P  PP     
Sbjct: 212 SQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGK--PQGPPAQGGS 269

Query: 388 NGSTSRALPATPQLPSRSGVDSPRSGPRPPL-----------------PPDRPSAGAPPP 430
              ++R+ P  PQ P +   ++P+ GP PP                  PP  P  G P  
Sbjct: 270 KSQSARSPPGKPQGPPQQEGNNPQ-GPPPPAGGNPQQPQAPPAGQPQGPPRPPQGGRPSR 328

Query: 431 PP 432
           PP
Sbjct: 329 PP 330



 Score =  115 bits (288), Expect = 9e-26
 Identities = 107/345 (31%), Positives = 139/345 (40%), Gaps = 35/345 (10%)

Query: 35  ALLSDISKGKKLKKTVTNDRSAPIL-DKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFG 93
           ALL+ +S  + L + V+ + S  ++   P+G    GG    G     G   G    G   
Sbjct: 9   ALLA-LSSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNK 67

Query: 94  GGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVP 153
             GPP  G   +   P  +   +R   S   +P   PP G +    P  PP G  + P P
Sbjct: 68  PQGPPPPG---KPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGP-PPPPGKPQGPPP 123

Query: 154 SPGHR-SGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQ 212
             G+R  GPP P + + PPP+ D    P S PP  P  P P Q     +G PP PG P+ 
Sbjct: 124 QGGNRPQGPPPPGKPQGPPPQGDKSRSPRS-PPGKPQGPPP-QGGNQPQGPPPPPGKPQG 181

Query: 213 PSPG----PTPPPFPGN-RGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPP 267
           P P     P  PP PG  +G    G   R    SS SP       PP         PPPP
Sbjct: 182 PPPQGGKKPQGPPPPGKPQGPPPQGDKSR----SSQSPPGKPQGPPPQGGNQPQGPPPPP 237

Query: 268 PPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPP--PPPPPSRPG--PPPLPP 323
             P G  P    +   PPPP   + P       S S+++PP  P  PP + G  P   PP
Sbjct: 238 GKPQGPPPQGGNKPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPP 297

Query: 324 SSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPP 368
            + GN + P+ P             P+    GP  PP   RP  P
Sbjct: 298 PAGGNPQQPQAP-------------PAGQPQGPPRPPQGGRPSRP 329



 Score =  108 bits (269), Expect = 1e-23
 Identities = 87/271 (32%), Positives = 100/271 (36%), Gaps = 61/271 (22%)

Query: 172 PRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALG 231
           P P  G+KP   PPP P  P+         G PP  G   Q  P P  P  P  +G    
Sbjct: 39  PSPQGGNKPQG-PPPPPGKPQ---------GPPPQGGNKPQGPPPPGKPQGPPPQGDK-- 86

Query: 232 GGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNK 291
                          S  P  PP        KP  PPP  GN+P       PPPPP    
Sbjct: 87  ---------------SRSPRSPP-------GKPQGPPPQGGNQPQ-----GPPPPPGK-- 117

Query: 292 PPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSP 351
              P  P P   ++   PPPP    GPPP    S      P  PQ         PP    
Sbjct: 118 ---PQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKPQ-------GPPPQGGN 167

Query: 352 GRSGPLPPPPSERPPPPVRDPPGRSGPLPP-----PPPVSRNGSTSRALPATPQLPSRSG 406
              GP PPPP +   PP +      GP PP     PPP      +S++ P  PQ P   G
Sbjct: 168 QPQGP-PPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQG 226

Query: 407 VDSPRSGPRPPLPPD--RPSAGAPP--PPPP 433
            + P+  P PP  P    P  G  P  PPPP
Sbjct: 227 GNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP 257



 Score =  103 bits (257), Expect = 4e-22
 Identities = 82/247 (33%), Positives = 91/247 (36%), Gaps = 37/247 (14%)

Query: 96  GPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGR--------STSAKPFSPPSGP 147
           GPP  GG    G P            GG+RP   PP G+          S  P SPP  P
Sbjct: 99  GPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPPPPGKPQGPPPQGDKSRSPRSPPGKP 158

Query: 148 GRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPP-VPSTPRP------IQSSPHN 200
              P        GPP P      PP P  G KP   PPP  P  P P         SP  
Sbjct: 159 QGPPPQGGNQPQGPPPPPGKPQGPP-PQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPG 217

Query: 201 RGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTP---- 256
           +   P P G  QP   P PP  P  +G    GG+  Q P     P   +P  PP      
Sbjct: 218 KPQGPPPQGGNQPQGPPPPPGKP--QGPPPQGGNKPQGP-----PPPGKPQGPPAQGGSK 270

Query: 257 ---SRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPP 313
              +R+   KP  PP   GN P        PPPP    P  P  P P+   Q PP PP  
Sbjct: 271 SQSARSPPGKPQGPPQQEGNNPQ------GPPPPAGGNPQQPQAP-PAGQPQGPPRPPQG 323

Query: 314 SRPGPPP 320
            RP  PP
Sbjct: 324 GRPSRPP 330



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 60/220 (27%), Positives = 76/220 (34%), Gaps = 50/220 (22%)

Query: 295 PSTPRPSASSQAPPPPPPPSRP-GPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGR 353
           P  P P   ++   PPPPP +P GPPP   +       P  PQ         PP     R
Sbjct: 36  PQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQ-------GPPPQGDKSR 88

Query: 354 SGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSG 413
           S   PP   + PPP      G + P  PPPP           P  PQ P   G + P+ G
Sbjct: 89  SPRSPPGKPQGPPPQ-----GGNQPQGPPPP-----------PGKPQGPPPQGGNRPQ-G 131

Query: 414 PRPPLPPDRP--------SAGAPP-----PPPPSTSIRNGFQDSPCEDEWESRFYFHPIS 460
           P PP  P  P        S  +PP     PPP   +   G    P + +           
Sbjct: 132 PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQG---------- 181

Query: 461 DLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPP 500
             PPP+   +     P    +     G   R   +PP  P
Sbjct: 182 --PPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKP 219



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 40/116 (34%), Positives = 46/116 (39%), Gaps = 20/116 (17%)

Query: 324 SSSGNDETPRLPQRNLSLSSSTPPLPSP--GRSGPLPPPPSERPPPPVRDPPGRSGPLPP 381
           SS+ N       + + SL +  P  PSP  G     PPPP  +P  P   P G + P  P
Sbjct: 14  SSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGP--PPQGGNKPQGP 71

Query: 382 PPPVSRNGSTSRALPATPQLPSRSG--VDSPRSGPRPPLPPDRPSAGAP--PPPPP 433
           PPP              PQ P   G    SPRS P  P  P       P  PPPPP
Sbjct: 72  PPP------------GKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPP 115


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
           sapiens]
          Length = 309

 Score =  127 bits (319), Expect = 2e-29
 Identities = 105/312 (33%), Positives = 122/312 (39%), Gaps = 58/312 (18%)

Query: 130 PPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPS 189
           P GG      P  P    GR P      +  PP P +   PPP+   G      PPP P 
Sbjct: 41  PQGGNQPQRTPPPPGKPEGRPPQGGNQSQGPPPRPGKPEGPPPQ---GGNQSQGPPPRPG 97

Query: 190 TP--RPIQSSPHNRGSPPVPGGPRQPSP-----GPTPPPFPGN-RGTALGGGSIRQSPLS 241
            P  +P Q    ++G PP PG P  P P        PPP PG   G    GG+  Q P  
Sbjct: 98  KPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGP-- 155

Query: 242 SSSPFSNRPPLPPTPSRALDDKPPPPP-PPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300
              P   +P  PP         PPP P  P G  P    ++  PPP    +P  P  P P
Sbjct: 156 --PPRPGKPEGPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGPPP----RPGKPEGPPP 209

Query: 301 SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP 360
              +Q+  PPP   RPG P  PPS  GN      PQ          P P PG+  P  PP
Sbjct: 210 QGGNQSQGPPP---RPGKPEGPPSQGGNK-----PQG---------PPPHPGK--PQGPP 250

Query: 361 PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420
           P E   P    PPGR  P  PPPP    G+  + LP             P   P+ P PP
Sbjct: 251 PQEGNKPQRPPPPGR--PQGPPPP---GGNPQQPLPP------------PAGKPQGPPPP 293

Query: 421 DRPSAGAPPPPP 432
             P  G P  PP
Sbjct: 294 --PQGGRPHRPP 303



 Score =  111 bits (278), Expect = 1e-24
 Identities = 110/362 (30%), Positives = 133/362 (36%), Gaps = 81/362 (22%)

Query: 35  ALLSDISKGKKLKKTVTNDRSAPILD-KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFG 93
           ALL+ +S  + L + V+ + S  ++  KP+G    GG          G   G    G   
Sbjct: 9   ALLA-LSSAQSLNEDVSQEESPSVISGKPEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQ 67

Query: 94  GGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVP 153
             GPP      + G P+               PP  P GG  +   P  P    G+ P  
Sbjct: 68  SQGPPP-----RPGKPE--------------GPP--PQGGNQSQGPPPRPGKPEGQPPQG 106

Query: 154 SPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPR--PIQSSPHNRGSPPVPGGPR 211
               +  PP P +   PPP+   G      PPP P  P   P Q    ++G PP PG P 
Sbjct: 107 GNQSQGPPPRPGKPEGPPPQ---GGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPE 163

Query: 212 QPSP-----GPTPPPFPGN-RGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP 265
            P P        PPP PG   G    GG+  Q P             PP P      KP 
Sbjct: 164 GPPPQGGNQSQGPPPHPGKPEGPPPQGGNQSQGP-------------PPRPG-----KPE 205

Query: 266 PPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSS 325
            PPP  GN+          PPP+  KP  P    PS     P  PPP   PG P  PP  
Sbjct: 206 GPPPQGGNQSQ-------GPPPRPGKPEGP----PSQGGNKPQGPPP--HPGKPQGPPPQ 252

Query: 326 SGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV 385
            GN      PQR           P PGR    PPPP   P  P+  P G+    PPPP  
Sbjct: 253 EGNK-----PQRP----------PPPGRPQG-PPPPGGNPQQPLPPPAGKPQGPPPPPQG 296

Query: 386 SR 387
            R
Sbjct: 297 GR 298



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 42/136 (30%), Positives = 49/136 (36%), Gaps = 24/136 (17%)

Query: 96  GPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPG---RFPV 152
           GPP  GG    G P            GG++    PP       KP  PPS  G   + P 
Sbjct: 185 GPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPP----RPGKPEGPPSQGGNKPQGPP 240

Query: 153 PSPGHRSGPPEPQRN---RMPPPR------PDVGSKPDSIPPPVPSTPRPIQSSPHNRGS 203
           P PG   GPP  + N   R PPP       P  G+    +PPP           P     
Sbjct: 241 PHPGKPQGPPPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPA--------GKPQGPPP 292

Query: 204 PPVPGGPRQPSPGPTP 219
           PP  G P +P  G  P
Sbjct: 293 PPQGGRPHRPPQGQPP 308


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score =  119 bits (297), Expect = 8e-27
 Identities = 110/358 (30%), Positives = 144/358 (40%), Gaps = 61/358 (17%)

Query: 115 ANRDNDSGGSRPPLLPPGGRS--TSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPP 172
           A R   +GG    L  P  RS  +SA P S P+  G      P  R  P  P     P P
Sbjct: 215 ARRRPSAGGG---LQRPASRSLSSSATPLSSPARSG------PSARGTPRAPAHPSQPKP 265

Query: 173 RPDVGSKPDSIPPPVPSTPR---PIQSSPHNRGSPPVPGGPRQP---SPGPTPPPFPGNR 226
           +     +P  + PP         P+ SSP    SP  P  P  P      P+PP  P ++
Sbjct: 266 KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQ 325

Query: 227 GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPP 286
            T     S+    L ++  F   PPL P  +      PPP  PP    P +     PP  
Sbjct: 326 ATT----SLGSPTLQATHSFLPSPPLSPLAT------PPPQAPPALALPPLQAPPSPPAS 375

Query: 287 PQNNKPPVPSTPRPSASS----QAP--PPPPPP-----SRPGPPPLPPSSSGNDETPRLP 335
           P  +    PS   P+A +    QAP  PPP PP     S P  PP+ PS++   + P   
Sbjct: 376 PPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP-- 433

Query: 336 QRNLSLSSSTPPL---PSPGRSGPLPPP--PSERPPPPVRDPPGRSGPLPPPPPVSRNGS 390
                 S + PPL   PSP  S P+ P   P  + PPP+  PP +    PP  P +    
Sbjct: 434 ------SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 487

Query: 391 TSRALPATPQ--------LPSRSGVDSPRSGPRPPLPP--DRPSAGAPPPPPPSTSIR 438
             +ALP+ P          PS S   SP + P P  PP    P    PP PP S +++
Sbjct: 488 PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 545



 Score =  102 bits (255), Expect = 6e-22
 Identities = 114/386 (29%), Positives = 138/386 (35%), Gaps = 51/386 (13%)

Query: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGS--KPDSI 183
           P L  P  ++  + P SPP  P   P P   +       Q    PPP P V +   P + 
Sbjct: 359 PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 418

Query: 184 PPPVPSTPRPIQSSPHNRGSPPV---PGGPRQP--SPGPTPPPFPGNRGTALGGGSIRQS 238
           PP  PS   P Q+ P +  +PP+   P  P  P  SP  TPPP               Q+
Sbjct: 419 PPVSPSATPPSQAPP-SLAAPPLQVPPSPPASPPMSPSATPPP---------------QA 462

Query: 239 PLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTP 298
           P          PPL   P +    KPPP  PP    P +     PP       P  PS  
Sbjct: 463 P----------PPLAAPPLQLA--KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS 510

Query: 299 RPSASSQAPPPPPPPSRPGP----PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRS 354
            P +    PPP  PP    P    PP PP+S       R P      S S P L      
Sbjct: 511 LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP 570

Query: 355 GPLPPPPSERPPPPVRDP--PGRSGPLPPPPPVSR--NGSTSRALPATPQLPSRSGVDSP 410
           GP PPPPS  P   +  P   G S      P   R  +        A+P   +      P
Sbjct: 571 GP-PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHP 629

Query: 411 RSGPRPPLPP--DRPSAGAPPPPPPSTSIRNGFQDSPC---EDEWESRFYFHPISDLPPP 465
            +  R P PP   R + GAP P PP+T    G  D  C   E E        P +  P P
Sbjct: 630 AAWSRGPAPPLAFRGAPGAPLPWPPATG--PGSADGLCTIYETEGPESATPAPGALDPGP 687

Query: 466 EPYVQTTKSYPSKLARNESRSGSNRR 491
            P     K+     A   SRS    R
Sbjct: 688 SPGTSGGKAAAGAGAGASSRSPKQAR 713



 Score =  100 bits (249), Expect = 3e-21
 Identities = 115/389 (29%), Positives = 144/389 (37%), Gaps = 72/389 (18%)

Query: 101 GGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG 160
           GG+  A +P+   +A R   +  SRPP    G R+  AK  SP       PV SPG  SG
Sbjct: 63  GGIGGATIPE---SAPRAGPTRTSRPPASGRGERAPPAKNTSPG------PVSSPGRASG 113

Query: 161 PPEPQ------------------RNRMPPPRP--DVGSKPDSIPPPVPSTPRPIQSSPHN 200
              P                   +    P R     G++ D+   P P TP P  +   +
Sbjct: 114 TTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDT-SGPTPGTPSPAMAR-RS 171

Query: 201 RGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPP-----LPPT 255
           R +    G PR   P P+  P P   G      S  +   +  SP + R P     L   
Sbjct: 172 RAAGTEVGLPR---PAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP 228

Query: 256 PSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKP--------PVPSTPRPSAS---- 303
            SR+L     P   P  + PS       P  P   KP        P  + PR  A+    
Sbjct: 229 ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALG 288

Query: 304 --SQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPP-------LPSPGRS 354
             S +P   P PS P  P  PPS       P  P    + S  +P        LPSP  S
Sbjct: 289 PLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS 348

Query: 355 GPLPPPPSERPP----PPVRDPPG--RSGPLPP---PPPVSRNGSTSRALPATPQLPSRS 405
            PL  PP + PP    PP++ PP    S PL P   P P + N      L A    P   
Sbjct: 349 -PLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSP 407

Query: 406 GVDSPRSGPRPPLPPDRPSAGAPPPPPPS 434
            V +P S P    PP  PSA  P   PPS
Sbjct: 408 PVQAPFSPPAS--PPVSPSATPPSQAPPS 434



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 116/426 (27%), Positives = 148/426 (34%), Gaps = 139/426 (32%)

Query: 210 PRQP-SPGPTPPPFP-----------------GNRGTALGGGSIRQSPLSSSSPFSNRPP 251
           PR P SP P PP  P                   R   +GG +I +S   +    ++RPP
Sbjct: 27  PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRTSRPP 86

Query: 252 -------LPP----------TPSRALDDKPPPPPPPVGNRPSIH-------------REA 281
                   PP          +P RA     P P    G R S               R A
Sbjct: 87  ASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA 146

Query: 282 VPPPPPQNNKPPVPSTPRPSASSQAP--------PPPPPPSRPGPP-------------- 319
           +     ++   P P TP P+ + ++         P P P +RP PP              
Sbjct: 147 LSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEH 206

Query: 320 ----PLP-----PSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGP-------LPPPPSE 363
               P P     PS+ G  + P     + SLSSS  PL SP RSGP        P  PS+
Sbjct: 207 STTEPSPAARRRPSAGGGLQRP----ASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 262

Query: 364 ---------RPP---PPVRDPPGRSGPL------------PPPPPVSRNGSTSRALPATP 399
                    RPP   PP +D     GPL            PP P    +  T  + PATP
Sbjct: 263 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATP 322

Query: 400 QLPSRSGVDSPRSG------PRPPL------PPDRPSA------GAPPPPPPSTSIRNGF 441
              + + + SP         P PPL      PP  P A       APP PP S  +    
Sbjct: 323 PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLA 382

Query: 442 QDSP-CEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRR--ERGAPPL 498
             SP   +         P S  PPP P VQ   S P+    + S +  ++      APPL
Sbjct: 383 TPSPQAPNALAVHLLQAPFS--PPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPL 440

Query: 499 --PPIP 502
             PP P
Sbjct: 441 QVPPSP 446



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 62/252 (24%), Positives = 88/252 (34%), Gaps = 53/252 (21%)

Query: 297 TPRPSASSQAPPPPPPPSRPGPPPLPPS------SSGNDETPRLPQRNLSLSSSTPPLPS 350
           TP   A     P PP   RP PPP+ P+      ++G      L +R   +  +T P  +
Sbjct: 16  TPAARAPGLLTPRPPGSPRP-PPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74

Query: 351 PGRSGPL----PP--------PPSERPPPPVRDPPGRSGPLPPPPPVSRNG--------- 389
           P R+GP     PP        PP++   P     PGR+     P P+ + G         
Sbjct: 75  P-RAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETV 133

Query: 390 STSRALPATPQLPSRSGVDSPRSGPRPPLPP----------------DRPSAGAPPPPP- 432
           +  +A  A  +    +G     SGP P  P                  RP+  A P PP 
Sbjct: 134 ARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPT 193

Query: 433 --PSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNR 490
             P  S+ +  + S  E    +R        L  P      ++S  S      S + S  
Sbjct: 194 EGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRP-----ASRSLSSSATPLSSPARSGP 248

Query: 491 RERGAPPLPPIP 502
             RG P  P  P
Sbjct: 249 SARGTPRAPAHP 260



 Score = 36.2 bits (82), Expect = 0.071
 Identities = 30/99 (30%), Positives = 39/99 (39%), Gaps = 14/99 (14%)

Query: 342 SSSTPPLPSPGRSGPLPPPPSERPPPPVRDPP----GRSGPLPPPPPVSRNGSTSRALPA 397
           ++ TP   +PG   P PP    RPPPPV        G +G +   P   R G    A   
Sbjct: 13  AARTPAARAPGLLTPRPPGS-PRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA--T 69

Query: 398 TPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTS 436
            P+        +PR+GP     P     G   PP  +TS
Sbjct: 70  IPE-------SAPRAGPTRTSRPPASGRGERAPPAKNTS 101



 Score = 29.6 bits (65), Expect = 6.7
 Identities = 26/90 (28%), Positives = 34/90 (37%), Gaps = 8/90 (8%)

Query: 2   PVPPPPAP------PPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRS 55
           P    PAP      P P T             + ++ + A L ++  G      V +  S
Sbjct: 673 PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLS 732

Query: 56  APILDKPKGAGAGGGGGGFGG--GGGFGGG 83
             +L       AGG GGG GG  GGG  GG
Sbjct: 733 RTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 762



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 14/25 (56%), Positives = 14/25 (56%)

Query: 65  AGAGGGGGGFGGGGGFGGGGGGGGG 89
           A A G  GG GGG G   GGG  GG
Sbjct: 738 AAAEGAAGGSGGGPGGAEGGGVTGG 762



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 13/26 (50%), Positives = 13/26 (50%)

Query: 75  GGGGGFGGGGGGGGGGSFGGGGPPGL 100
           G  GG GGG GG  GG   GG    L
Sbjct: 742 GAAGGSGGGPGGAEGGGVTGGARAAL 767


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score =  119 bits (297), Expect = 8e-27
 Identities = 120/418 (28%), Positives = 153/418 (36%), Gaps = 78/418 (18%)

Query: 89  GGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPP-------GGRSTSAKPF 141
           GGS G G  P       + +P L       +  G  RPP  P        G  S S  P 
Sbjct: 540 GGSEGAGAAPCPPNPANSWVPGL-------SPGGSRRPPRSPERTLSPSSGYSSQSGTPT 592

Query: 142 SPPSGPGRFPVPSPGHRSGPPEPQR-NRMPPPRPDVGSKPDSI----PPPVPST---PRP 193
            PP G    P  SPG ++ PP+P+R   +  P   V S   S+      P PS    P+ 
Sbjct: 593 LPPKGLAG-PPASPG-KAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQI 650

Query: 194 IQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLP 253
           +         PP P  P   SP P+ P  P     AL   ++   P+S++      PP P
Sbjct: 651 LTPLGDRFVIPPHPKVPAPFSPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTP 710

Query: 254 PTPSRALDDKP-------PPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306
            T    L + P       PPP PP    PS H    PPPPP      V   P  S +++ 
Sbjct: 711 QTTLTPLQESPVISKDQSPPPSPP----PSYH----PPPPPTKKPEVVVEAPSASETAEE 762

Query: 307 P------PPPPPPSRPG--------PPP-------LPPSSSGNDETPRLPQRNLSLSSST 345
           P      PPPPPP+           PPP         P  +G   +P L     + SSS 
Sbjct: 763 PLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSA 822

Query: 346 PPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV--SRNGSTSR-------ALP 396
             L       P  PPP+   P P    PG    LP   PV  S+ G   R         P
Sbjct: 823 TALQIQPPGSP-DPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPREDVGAPLVTP 881

Query: 397 ATPQLPSRSGVDSPRSGPRPPLPPDRP--------SAGAPPPPPPSTSIRNGFQDSPC 446
           +  Q+     V +P   P P L P  P        S  A P P PS+ +    +   C
Sbjct: 882 SLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRASPVPAPSSGLHAAVRLKAC 939



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 118/419 (28%), Positives = 152/419 (36%), Gaps = 95/419 (22%)

Query: 85  GGGGGGSFGGGGPPGLG---GLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF 141
           GG G GS  GG          +  +G    RS + R       RPP  P    S   +  
Sbjct: 457 GGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKL----KRPPPPPRRTHSLHQRGL 512

Query: 142 SPPSGPGRFP----------VPSPGHRSG---------PPEPQRNRMPPPRPDVGSKPDS 182
           + P GP   P          +P P    G         PP P  + +P   P    +P  
Sbjct: 513 AVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPR 572

Query: 183 IPPPVPSTPRPIQSSPHNRGSPPVP----GGPRQPSPGPTPPPFPGNRGTALG--GGSIR 236
            P     T  P        G+P +P     GP   SPG   PP P  R T+L   G S+ 
Sbjct: 573 SPE---RTLSPSSGYSSQSGTPTLPPKGLAGP-PASPGKAQPPKP-ERVTSLRSPGASVS 627

Query: 237 QSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPS 296
            S  S  S  S+     P PS   D   P    P+G+R       +PP P    K P P 
Sbjct: 628 SSLTSLCSSSSD-----PAPS---DRSGPQILTPLGDR-----FVIPPHP----KVPAPF 670

Query: 297 TPRPSASSQAPPPPPPPSRPGPPPLPPSSS-GNDETPRLPQRNLSLSSSTPPLPSPGRSG 355
           +P PS      P  P  + P   P P S++  + ++P  PQ  L+    +P +       
Sbjct: 671 SPPPSKPRSPNPAAPALAAPAVVPGPVSTTDASPQSPPTPQTTLTPLQESPVISKDQSPP 730

Query: 356 PLPPPPSERPPPPVRDP------PGRS----GPL------PPPPPVSRNGSTSRA----- 394
           P PPP    PPPP + P      P  S     PL      PPPPP       S A     
Sbjct: 731 PSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPP 790

Query: 395 -----LPATPQLPSRSG----VDSPRSGP--------RPPLPPDRPSAGAPPPPPPSTS 436
                  A+P+    SG    V SP +          +PP  PD P   APP P P++S
Sbjct: 791 EEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPDPPP--APPAPAPASS 847



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 102/425 (24%), Positives = 143/425 (33%), Gaps = 73/425 (17%)

Query: 121 SGGSRPPLLPPGGRSTSAKPF--SPPSGPGRFPVPSPGHRSGPPEPQRN-RMPPPRP--- 174
           S  S   + PP G S    P   S         + S G  SG     R  + PPP P   
Sbjct: 445 STASNSVVPPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRT 504

Query: 175 -DVGSKPDSIPP-PVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGG 232
             +  +  ++P  P+   P+P +        PP  GG       P PP    +    L  
Sbjct: 505 HSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSP 564

Query: 233 GSIRQSP------LSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPP 286
           G  R+ P      LS SS +S++   P  P + L   P  P            +A PP P
Sbjct: 565 GGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPG-----------KAQPPKP 613

Query: 287 PQNNKPPVPSTPRPSASSQ---APPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSS 343
            +      P     S+ +    +   P P  R GP  L P        P           
Sbjct: 614 ERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPH---------- 663

Query: 344 STPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPS 403
             P +P+P      PPP   R P P    P  + P   P PVS   ++ ++ P TPQ   
Sbjct: 664 --PKVPAPFS----PPPSKPRSPNPA--APALAAPAVVPGPVSTTDASPQS-PPTPQTTL 714

Query: 404 RSGVDSPRSGPRPPLPPDRPSAGAPPPPP---PSTSIRNGFQDSPCEDEWESRFYFHP-- 458
               +SP        PP  P +  PPPPP   P   +         E+  +   +  P  
Sbjct: 715 TPLQESPVISKDQSPPPSPPPSYHPPPPPTKKPEVVVEAPSASETAEEPLQDPNWPPPPP 774

Query: 459 ---------ISDLPPPEPYVQTTKS------------YPSKLARNESRSGSNRRERGAPP 497
                    ++D PPPE    +  S              S  A + S +    +  G+P 
Sbjct: 775 PAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELVSSPAASSSSATALQIQPPGSPD 834

Query: 498 LPPIP 502
            PP P
Sbjct: 835 PPPAP 839



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 81/306 (26%), Positives = 112/306 (36%), Gaps = 61/306 (19%)

Query: 131  PGGRSTSAKPFSPPSGPGRFPVPSPGHRS------GPPEPQRNRMPPPRPDVGS-KPDSI 183
            P    T+ +P   P+ P   P P+P  +        PPE     +  P P   S  P+ +
Sbjct: 754  PSASETAEEPLQDPNWPPP-PPPAPEEQDLSMADFPPPEEAFFSVASPEPAGPSGSPELV 812

Query: 184  PPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPP------PFPGNRGTALGGGSIRQ 237
              P  S+           GSP  P  P  P+P  + P      P     G + GGG  R+
Sbjct: 813  SSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPRE 872

Query: 238  ---SPLSSSSPFS-------NRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPP 287
               +PL + S            P   PTP+      P  P  P+  R ++   A P P P
Sbjct: 873  DVGAPLVTPSLLQMVRLRSVGAPGGAPTPALG----PSAPQKPL--RRALSGRASPVPAP 926

Query: 288  QNN-----KPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSG--------------- 327
             +      +    S       S A P  PP + P PP  P S++                
Sbjct: 927  SSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGSRKLQLERP 986

Query: 328  -NDETPRLPQRNL-----SLSSSTPPLPSPGRSGPLPPPPSERP----PPPVRDPPGRSG 377
             + ET    QRNL     S+S   PP  +P +S   PPP + +P    PPP      R+ 
Sbjct: 987  VSPETQADLQRNLVAELRSISEQRPP-QAPKKSPKAPPPVARKPSVGVPPPASPSYPRAE 1045

Query: 378  PLPPPP 383
            PL  PP
Sbjct: 1046 PLTAPP 1051



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 73/295 (24%), Positives = 104/295 (35%), Gaps = 45/295 (15%)

Query: 106  AGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS-PGHRSGPPEP 164
            +G P+L S+    + S  +   + PPG       P  PP+ P   P  S PGH +  P+ 
Sbjct: 806  SGSPELVSSPAASSSSATALQ-IQPPGS------PDPPPAPPAPAPASSAPGHVAKLPQK 858

Query: 165  Q----RNRMPPPRPDVGSK-----------------PDSIPPPV--PSTP-RPIQSSPHN 200
            +         PPR DVG+                  P   P P   PS P +P++ +   
Sbjct: 859  EPVGCSKGGGPPREDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSG 918

Query: 201  RGSP-PVPGGPRQPSPGPTPPPFPGNRG--TALGGGSIRQSPLSSSSPFSNRPPLPPTPS 257
            R SP P P      +          + G  +A   G     P    SP S    +    S
Sbjct: 919  RASPVPAPSSGLHAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQSPASTASFIFSKGS 978

Query: 258  RALDDKPPPPPPP--------VGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP 309
            R L  + P  P          V    SI  +  P  P ++ K P P   +PS     PPP
Sbjct: 979  RKLQLERPVSPETQADLQRNLVAELRSISEQRPPQAPKKSPKAPPPVARKPSVG--VPPP 1036

Query: 310  PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSER 364
              P      P   P ++G   T    +R L+ +     L  P     LP   S++
Sbjct: 1037 ASPSYPRAEPLTAPPTNGLPHTQDRTKRELAENGGVLQLVGPEEKMGLPGSDSQK 1091


>gi|47132519 Ras association and pleckstrin homology domains 1 isoform
            1 [Homo sapiens]
          Length = 1250

 Score =  118 bits (296), Expect = 1e-26
 Identities = 115/366 (31%), Positives = 146/366 (39%), Gaps = 63/366 (17%)

Query: 116  NRDNDSGGSRPPLLPPGGRSTSAKP--FSPPSGPGRFPVPSPGHRSGPPEP-QRNRMPPP 172
            N    SG    P  PP  +S S KP    PP+G     VP P     PP P        P
Sbjct: 675  NASQHSGALFKPPTPPVMQSQSVKPQILVPPNGV----VPPPPPPPPPPTPGSAMAQLKP 730

Query: 173  RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGG 232
             P   S P    PP P     +Q     + +PP P  P  P P P PP  P      +  
Sbjct: 731  APCAPSLPQFSAPPPPLKIHQVQHI--TQVAPPTPPPP-PPIPAPLPPQAPPKPLVTIPA 787

Query: 233  GSIRQSP---LSSSSPFSNRPPLPPT------PSRALDDKPPPPPPPVGNRPSIHRE--- 280
             +  ++    ++ ++P +  PP+PP       P+  +   PP PP PV   P++ ++   
Sbjct: 788  PTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPP-PTLPKQQSF 846

Query: 281  -AVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPP--PLP--------------- 322
             A PPP P +   PVPS  +  AS Q PPPP PP+    P  P+P               
Sbjct: 847  CAKPPPSPLS---PVPSVVKQIAS-QFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKP 902

Query: 323  ---PSS---SGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRS 376
               PSS      D  P  P+ +L      PP PSP  + P PPPP+  P P     PG+ 
Sbjct: 903  KWQPSSIPVPSPDFPPPPPESSLVF---PPPPPSPVPAPPPPPPPTASPTPDKSGSPGKK 959

Query: 377  -------GPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPP 429
                   G   PPP   RN S   +  A    P R  VDS  S   PP     PS    P
Sbjct: 960  TSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLP 1019

Query: 430  PP--PP 433
            PP  PP
Sbjct: 1020 PPAAPP 1025



 Score =  110 bits (274), Expect = 4e-24
 Identities = 125/490 (25%), Positives = 167/490 (34%), Gaps = 119/490 (24%)

Query: 102 GLFQAGMPKLRSTANRDNDSGGS-RPPLLPPGGRSTSAKPFSPPSGPG-RFPVPSPGHRS 159
           G   + +P+ +S  +  +DSG S   P      +S  +  FS     G +    S     
Sbjct: 537 GSSSSSIPESQSNHSNQSDSGVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARME 596

Query: 160 GPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTP 219
               P  + +PP  P    +P  + P   S P P    P      P P  P  P P P P
Sbjct: 597 SMNRPYTSLVPPLSP----QPKIVTPYTASQPSPPLPPP------PPPPPPPPPPPPPPP 646

Query: 220 PPFPGNRGTALGGGS---------IRQSPLSSSSPFSNRPPLPPT-------------PS 257
           PP P     + G  +          R    S  S    +PP PP              P+
Sbjct: 647 PPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPN 706

Query: 258 RALDDKPPPPPPPVGN-----------RPSIHREAVPPPPPQNNK--------PPVPSTP 298
             +   PPPPPPP               PS+ + + PPPP + ++        PP P  P
Sbjct: 707 GVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPP 766

Query: 299 RPSASSQAPPPPPPP--SRPGP-------------------PPLPPSSSGNDETPRLPQR 337
            P  +   P  PP P  + P P                   PP+PP+     + P  P  
Sbjct: 767 PPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAK----KQPAFPAS 822

Query: 338 NLSLSSSTPPLPSPGRSGP------LPPPPSERPP------------PPVRDPPGRSGPL 379
            +  S  TPP+P P  + P        PPPS   P            PP   PP      
Sbjct: 823 YIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQP 882

Query: 380 PPPPPVSRNGSTSRALPATPQ-LPSRSGVDSPRSGPRP-------PLPPDRPSAGAPPPP 431
             P P +    +  A+ A P+  PS   V SP   P P       P PP  P    PPPP
Sbjct: 883 LKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPP 942

Query: 432 PPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRR 491
           PP+ S       SP +   ++     P    PPP P             RN S   S+  
Sbjct: 943 PPTASPTPDKSGSPGKKTSKTS---SPGGKKPPPTP------------QRNSSIKSSSGA 987

Query: 492 ERGAPPLPPI 501
           E   P  P +
Sbjct: 988 EHPEPKRPSV 997



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 94/345 (27%), Positives = 118/345 (34%), Gaps = 47/345 (13%)

Query: 126  PPLLPPGGRSTSAKPF-------SPPS-------GPGRFPVPSPGHRSGPPEPQRNRMPP 171
            PP  PP   S   KP        SPP+        P   PVPSP     PPE      PP
Sbjct: 871  PPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVFPPP 930

Query: 172  PRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALG 231
            P       P  +P P P  P     +P   GSP           G  PPP P  R +++ 
Sbjct: 931  P-------PSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP-QRNSSIK 982

Query: 232  GGSIRQSPL----SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVG--------NRPSIHR 279
              S  + P     S  S  S   P   + S + +  PPP  PP          N P + +
Sbjct: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNLPGVLQ 1042

Query: 280  E----AVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL- 334
            +    A  P      K  V   P P + S  PPPPP    P PP   P+    + +P++ 
Sbjct: 1043 QGCVSAKAPVLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIEIPAVFSGNTSPKVA 1102

Query: 335  -----PQRNLSLS-SSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRN 388
                 PQ+   +S    PP   P R+       +E    P         P  P   +S  
Sbjct: 1103 VVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQ 1162

Query: 389  GSTSRALPATPQLPS--RSGVDSPRSGPRPPLPPDRPSAGAPPPP 431
                  L  T Q  S  R G  S R     P       A  PPPP
Sbjct: 1163 PGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 78/253 (30%), Positives = 93/253 (36%), Gaps = 40/253 (15%)

Query: 273 NRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLP---PSSSGND 329
           NRP  +   VPP  PQ       +  +PS     PPPPPPP  P PPP P   PS S   
Sbjct: 599 NRP--YTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPPPPPPPPPPLPSQSAPS 656

Query: 330 ETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP------SERPPPPVRDPP-GRSGPLPPP 382
                P   +  S+ T    +   SG L  PP      S+   P +  PP G   P PPP
Sbjct: 657 AGSAAPM-FVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVPPPPPP 715

Query: 383 PPVSRNGSTSRAL---PATPQLPSRSGVDSPR--------SGPRPPLPPDRPSAGAPPPP 431
           PP    GS    L   P  P LP  S    P         +   PP PP  P   AP PP
Sbjct: 716 PPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPP 775

Query: 432 --PPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSN 489
             PP   +       P     ++       +  P P P V   K  P+  A     S   
Sbjct: 776 QAPPKPLV-----TIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPS--- 827

Query: 490 RRERGAPPLPPIP 502
                 PP PP+P
Sbjct: 828 ------PPTPPVP 834



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 59/199 (29%), Positives = 72/199 (36%), Gaps = 55/199 (27%)

Query: 333 RLPQRNLSLSSSTPPL-PSPGRSGPL----PPPPSERPPPPVRDPPGRSGPLPPPPPVSR 387
           R+   N   +S  PPL P P    P     P PP   PPPP   PP    P PPPPP   
Sbjct: 594 RMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPP---PPPPPPPPPPPPPPLP 650

Query: 388 NGSTSRALPATPQLPSRSGVD-----SPRSG-----PRPP------------LPPDRPSA 425
           + S   A  A P     S +      S  SG     P PP            +PP+    
Sbjct: 651 SQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQSVKPQILVPPNGVVP 710

Query: 426 GAPPPPPPST--SIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNE 483
             PPPPPP T  S     + +PC           P    PPP          P K+ + +
Sbjct: 711 PPPPPPPPPTPGSAMAQLKPAPCAPSL-------PQFSAPPP----------PLKIHQVQ 753

Query: 484 SRSGSNRRERGAPPLPPIP 502
             +      + APP PP P
Sbjct: 754 HIT------QVAPPTPPPP 766



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 109/435 (25%), Positives = 140/435 (32%), Gaps = 136/435 (31%)

Query: 2    PVPPP---PAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPI 58
            P PPP   PAPPPPP      T  PT +K+            S GKK  KT     S+P 
Sbjct: 928  PPPPPSPVPAPPPPP----PPTASPTPDKSG-----------SPGKKTSKT-----SSP- 966

Query: 59   LDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRD 118
                                              GG  PP          P  +  ++  
Sbjct: 967  ----------------------------------GGKKPP----------PTPQRNSSIK 982

Query: 119  NDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGS 178
            + SG   P    P   S  +K F+PP+  G               P +  +PPP      
Sbjct: 983  SSSGAEHPEPKRPSVDSLVSK-FTPPAESG--------------SPSKETLPPP------ 1021

Query: 179  KPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQS 238
                  PP P           N     +PG  +Q       P   G      G  S+ + 
Sbjct: 1022 ----AAPPKP--------GKLNLSGVNLPGVLQQGCVSAKAPVLSGR-----GKDSVVEF 1064

Query: 239  PLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQN------NKP 292
            P   S   S+ PP PP     L   PP   P V +  +  + AV  P PQ        K 
Sbjct: 1065 PSPPSD--SDFPPPPPETELPL---PPIEIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKA 1119

Query: 293  PVPSTPRPSAS---SQAPPPPPPPSRPGPPPLP--PSSSGNDETPRLPQRNLSLSSSTPP 347
            P P+ P+ + S   +QA     P      P +P  P SS + +   L   N +L      
Sbjct: 1120 PPPTRPKRNDSTRLTQAEISEQPTMATVVPQVPTSPKSSLSVQPGFLADLNRTLQRK--- 1176

Query: 348  LPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGV 407
              S  R G L    S   P    D       LPPPPP   +         +      SG 
Sbjct: 1177 --SITRHGSLSSRMSRAEPTATMDDMA----LPPPPPELLSDQQKAGYGGS----HISGY 1226

Query: 408  DSPRSGPRPPLPPDR 422
             + R GP PP PP R
Sbjct: 1227 ATLRRGP-PPAPPKR 1240



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 12/23 (52%), Positives = 14/23 (60%)

Query: 2   PVPPPPAPPPPPTFALANTEKPT 24
           P PPPP PPPPP   L +   P+
Sbjct: 634 PPPPPPPPPPPPPPPLPSQSAPS 656



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 11/12 (91%), Positives = 11/12 (91%)

Query: 3   VPPPPAPPPPPT 14
           VPPPP PPPPPT
Sbjct: 709 VPPPPPPPPPPT 720



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 10/13 (76%), Positives = 11/13 (84%)

Query: 1   MPVPPPPAPPPPP 13
           +P PPPP PPPPP
Sbjct: 628 LPPPPPPPPPPPP 640



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 10/12 (83%), Positives = 10/12 (83%)

Query: 2   PVPPPPAPPPPP 13
           P PPPP PPPPP
Sbjct: 630 PPPPPPPPPPPP 641



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 10/12 (83%), Positives = 10/12 (83%)

Query: 2   PVPPPPAPPPPP 13
           P PPPP PPPPP
Sbjct: 631 PPPPPPPPPPPP 642



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 10/12 (83%), Positives = 10/12 (83%)

Query: 2   PVPPPPAPPPPP 13
           P PPPP PPPPP
Sbjct: 632 PPPPPPPPPPPP 643



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 10/12 (83%), Positives = 10/12 (83%)

Query: 2   PVPPPPAPPPPP 13
           P PPPP PPPPP
Sbjct: 633 PPPPPPPPPPPP 644



 Score = 30.0 bits (66), Expect = 5.1
 Identities = 11/18 (61%), Positives = 13/18 (72%)

Query: 1   MPVPPPPAPPPPPTFALA 18
           +P PPPP PPP P  A+A
Sbjct: 709 VPPPPPPPPPPTPGSAMA 726


>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
          Length = 639

 Score =  116 bits (290), Expect = 5e-26
 Identities = 107/337 (31%), Positives = 129/337 (38%), Gaps = 71/337 (21%)

Query: 148 GRFPVP-SPGHRSGP--------PEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSP 198
           G  PVP S G  SGP        P P      PP P + S   S PP + S P   +S P
Sbjct: 321 GEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPS--ESRP 378

Query: 199 HNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPT--P 256
           ++      PGGP    P   P P P   G   GG  ++ +P     P+   PP P    P
Sbjct: 379 YHGMHGGGPGGP-GGGPHSFPHPLPSLTG-GHGGHPMQHNPNGPPPPWMQPPPPPMNQGP 436

Query: 257 SRALDDKPPP------------------------PPPPVGNRPSIHREAVPPPPPQNNKP 292
                  PPP                        PPPP+G  P       PPPPP    P
Sbjct: 437 HPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPP------PPPPPSGQPP 490

Query: 293 PVPSTPRP--SASSQAPPPPPPP--SRPGPPPLP--------PSSSGNDETPRLPQRNLS 340
           P PS P P      Q PPPPPPP  S     PLP         +S+G    P   Q+  +
Sbjct: 491 PPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAA 550

Query: 341 LSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQ 400
            ++S       G    +P PP  +PP     PPG   P PPPPP S     +   P  P 
Sbjct: 551 AAASPGAPQMQGNPTMVPLPPGVQPPL----PPGAPPPPPPPPPGSAGMMYAPPPPPPPP 606

Query: 401 LPSRSGVDSPRSG--PRPP--LPPDRPSAGAPPPPPP 433
           +   + V     G    PP  +PP      APPPPPP
Sbjct: 607 MDPSNFVTMMGMGVAGMPPFGMPP------APPPPPP 637



 Score = 89.0 bits (219), Expect = 9e-18
 Identities = 99/361 (27%), Positives = 120/361 (33%), Gaps = 104/361 (28%)

Query: 2   PVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDK 61
           P  P   PPPP   +   +  P +N                            S P   +
Sbjct: 346 PAAPANNPPPPSLMSTTQSRPPWMN----------------------------SGPSESR 377

Query: 62  PKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDS 121
           P           + G  G G GG GGG  SF    P   GG    G P       + N +
Sbjct: 378 P-----------YHGMHGGGPGGPGGGPHSFPHPLPSLTGG--HGGHPM------QHNPN 418

Query: 122 GGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQ---------------- 165
           G   P + PP           PP   G  P   PGH   PP  Q                
Sbjct: 419 GPPPPWMQPP----------PPPMNQGPHP---PGHHGPPPMDQYLGSTPVGSGVYRLHQ 465

Query: 166 -RNRMPPP----RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPP 220
            +  MPPP     P     P   PPP PS P P       +  PP P  P       TP 
Sbjct: 466 GKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPP--PSSSMASSTPL 523

Query: 221 PFPGNRGT---ALGGGSI----RQSPLSSSSP----FSNRP---PLPP--TPSRALDDKP 264
           P+  N  T   + G GSI    +Q   +++SP        P   PLPP   P       P
Sbjct: 524 PWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPP 583

Query: 265 PPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPS 324
           PPPPPP G+   ++    PPPPP +     PS             PP    P PPP PP 
Sbjct: 584 PPPPPPPGSAGMMYAPPPPPPPPMD-----PSNFVTMMGMGVAGMPPFGMPPAPPPPPPQ 638

Query: 325 S 325
           +
Sbjct: 639 N 639



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 90/342 (26%), Positives = 117/342 (34%), Gaps = 95/342 (27%)

Query: 230 LGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPP--------PPPVGNRPSIHR-- 279
           LG   +  S  S+S P +      P P+   ++ PPP         PP + + PS  R  
Sbjct: 320 LGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPY 379

Query: 280 ---------------EAVPPPPPQ----NNKPPVPSTPR-PSASSQAPPPPP------PP 313
                           + P P P     +   P+   P  P      PPPPP      PP
Sbjct: 380 HGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPP 439

Query: 314 SRPGPPPL------PPSSSG----NDETPRLPQRNLSLSSSTPPLPS----PGRSGPLPP 359
              GPPP+       P  SG    +     +P   + +    PP PS    P  SGPLPP
Sbjct: 440 GHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPP 499

Query: 360 PPSER----PPPPVRDPPGRSGPLP---------------PPPPVSRNGSTSRALPATPQ 400
              ++    PPPP       S PLP                 PP  +  + + A P  PQ
Sbjct: 500 WQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQ 559

Query: 401 LPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPIS 460
           +     +     G +PPLPP     GAPPPPPP      G   +P               
Sbjct: 560 MQGNPTMVPLPPGVQPPLPP-----GAPPPPPPPPPGSAGMMYAP--------------- 599

Query: 461 DLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIP 502
             PPP P +      PS          +     G PP PP P
Sbjct: 600 -PPPPPPPMD-----PSNFVTMMGMGVAGMPPFGMPPAPPPP 635


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score =  115 bits (288), Expect = 9e-26
 Identities = 125/432 (28%), Positives = 148/432 (34%), Gaps = 65/432 (15%)

Query: 47  KKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGG-GGGGGGGGSFGGGGPPGLGGLFQ 105
           +K    +R AP    P+GA    G  G  GG G  G  G  GG GS G  GPPG  G   
Sbjct: 502 EKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQG--- 558

Query: 106 AGMPKLRSTANRDNDSGGSRPPLLP-----PGGRSTSAKP-----FSPPSGPGRFPVPSP 155
                    + R    G S P   P     PG +     P        P GPG    P  
Sbjct: 559 --------ESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGK 610

Query: 156 GHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSP 215
              +GP  P     P P    G K D+ PP     P+ +Q  P   G P   G P +P P
Sbjct: 611 NGETGPQGP-----PGPTGPGGDKGDTGPP----GPQGLQGLPGTGGPPGENGKPGEPGP 661

Query: 216 --GPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGN 273
                 P  PG +G A G    R  P  + +P       PP P        PP PP    
Sbjct: 662 KGDAGAPGAPGGKGDA-GAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAG 720

Query: 274 RPSI-----HREAVPPPPPQNNKPPVPSTPRPSA--SSQAPPPPPPPSRPGPPPLPPSSS 326
            P +      R  +  P P+ +K   P  P          P  P  P  P  P   P   
Sbjct: 721 TPGLQGMPGERGGLGSPGPKGDKGE-PGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDK 779

Query: 327 GNDETPRLPQRNLSLSS------STPPLP-----SPGRSGP--------LPPPPSERPPP 367
           G    P LP       S      + PP P     +PG++G          P    E  PP
Sbjct: 780 GEGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPP 839

Query: 368 PVRDPPGRSGPLPPPPPVSRNGST-SRALPATPQLPSRSGVDSP---RSGPRPPLPPDRP 423
            V  PPG SGP  PP P    G   S   P     P   G+  P      P PP P   P
Sbjct: 840 GVAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSP 899

Query: 424 SAGAPPPPPPST 435
               PP P  +T
Sbjct: 900 GKDGPPGPAGNT 911



 Score =  100 bits (249), Expect = 3e-21
 Identities = 120/405 (29%), Positives = 136/405 (33%), Gaps = 61/405 (15%)

Query: 56  APILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPG-LGGLFQAGMPKLRST 114
           A I   P   GA G  G  G  G  G  GG G  G  G  G PG  G   +AG+P +   
Sbjct: 401 AGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGA 460

Query: 115 ANRDNDSGGSRPP---LLPPGGRSTSAKPFSPPSGPGRFP----------VPSP-GHRSG 160
              D   G    P    LP       A  F  P+GP   P           P P G R  
Sbjct: 461 KGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGA 520

Query: 161 PPEPQRNRMP-------PPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPR-Q 212
             EP R+ +P        P    G   D  P P      P       R  PP P GPR Q
Sbjct: 521 AGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGP------PGSQGESGRPGPPGPSGPRGQ 574

Query: 213 PS----PGPT----PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKP 264
           P     PGP      P   G RG   GG   +  P  +       PP P  P     D  
Sbjct: 575 PGVMGFPGPKGNDGAPGKNGERG-GPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTG 633

Query: 265 PPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPS 324
           PP P  +   P         PP +N K   P  P P   + AP  P      G P     
Sbjct: 634 PPGPQGLQGLP-----GTGGPPGENGK---PGEPGPKGDAGAPGAPGGKGDAGAP----- 680

Query: 325 SSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPP-PPSERPPPPVRDPPGRSGPLPPPP 383
             G    P L         + PP P  G+    PP PP     P ++  PG  G L  P 
Sbjct: 681 --GERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAGTPGLQGMPGERGGLGSPG 738

Query: 384 PVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAP 428
           P    G      P  P      G D PR GP  P+ P  P AG P
Sbjct: 739 PKGDKGE-----PGGPGADGVPGKDGPR-GPTGPIGPPGP-AGQP 776



 Score =  100 bits (249), Expect = 3e-21
 Identities = 121/406 (29%), Positives = 143/406 (35%), Gaps = 84/406 (20%)

Query: 62   PKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDS 121
            P   G  G  G  G  G  G  GG G  G+ G  GPPGL     AG P LR         
Sbjct: 650  PGENGKPGEPGPKGDAGAPGAPGGKGDAGAPGERGPPGL-----AGAPGLR--------- 695

Query: 122  GGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS----PGHRS--GPPEPQRNRMPPPRPD 175
            GG+ PP  P GG+  +     PP  PG    P     PG R   G P P+ ++  P  P 
Sbjct: 696  GGAGPP-GPEGGKGAA----GPPGPPGAAGTPGLQGMPGERGGLGSPGPKGDKGEPGGPG 750

Query: 176  VGSKPDSIPP-----PV-PSTPRPIQSSPHNRGSPPVPG--GPRQPSPG-------PTPP 220
                P    P     P+ P  P          G+P +PG  GPR  SPG       P P 
Sbjct: 751  ADGVPGKDGPRGPTGPIGPPGPAGQPGDKGEGGAPGLPGIAGPR-GSPGERGETGPPGPA 809

Query: 221  PFPGNRGT--ALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIH 278
             FPG  G     GG   R +P          P +   P  +    PP P    G R S  
Sbjct: 810  GFPGAPGQNGEPGGKGERGAPGEKGE--GGPPGVAGPPGGSGPAGPPGPQGVKGERGS-- 865

Query: 279  REAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRN 338
                P  P     P     P P  S+  P PP P   PG    PP  +GN   P      
Sbjct: 866  ----PGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPGKDG-PPGPAGNTGAP------ 914

Query: 339  LSLSSSTPPLPSPGRSGPL--PPPPSERPPPPVRDPPGRSGPL-------------PPPP 383
                       SPG SGP      P E+  P  + PPG  GPL             PP  
Sbjct: 915  ----------GSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGM 964

Query: 384  PVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPP-LPPDRPSAGAP 428
            P  R     + +      P  +G+   R  P P  LP    +AG P
Sbjct: 965  PGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEP 1010



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 127/476 (26%), Positives = 164/476 (34%), Gaps = 75/476 (15%)

Query: 32  GRNALLSDI-SKGKKLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGG-GGG 89
           GRN    +  + G K +  +  +  AP    P+GA    G  G  G  G  G  G  G  
Sbjct: 270 GRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGSD 329

Query: 90  GSFGGGGPPGLGG----------LFQAGMPKLRSTANRDNDSG-----GSRPPLLPPG-- 132
           G  G  GPPG  G          +  AG P       +  + G     G++ P  PPG  
Sbjct: 330 GQPGPPGPPGTAGFPGSPGAKGEVGPAGSPGSNGAPGQRGEPGPQGHAGAQGPPGPPGIN 389

Query: 133 ---GRSTSAKPFSPPSGPGRF-----PVP-----SPGHRSGPPEPQRNRM---PPPRPDV 176
              G      P   P  PG       P P     +PG R G  EP +N     P PR   
Sbjct: 390 GSPGGKGEMGPAGIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPR--- 446

Query: 177 GSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSP----------GPT-PPPFPGN 225
           G + ++  P VP      +      GSP  PG    P            GP  P   PG 
Sbjct: 447 GERGEAGIPGVPGA----KGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGE 502

Query: 226 RGTALGGGSIRQSPLSSSSPFSNRPPLPPTPS-RALDDKPPPP-----PPPVGNRPSIHR 279
           +G A   G+   +    ++    R  +P  P  R +   P  P     P P G++    R
Sbjct: 503 KGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGR 562

Query: 280 EAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRP-GPPPLPPSSSGNDETPRLPQRN 338
              P P     +P V   P P  +  AP        P GP P  P     +  P+ P   
Sbjct: 563 PGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGPPGKNGETGPQGP--- 619

Query: 339 LSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSG-PLPPPP------PVSRNGST 391
                 T P    G +GP P P   +  P    PPG +G P  P P      P +  G  
Sbjct: 620 ---PGPTGPGGDKGDTGP-PGPQGLQGLPGTGGPPGENGKPGEPGPKGDAGAPGAPGGKG 675

Query: 392 SRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCE 447
               P     P  +G    R G  PP  P+     A PP PP  +   G Q  P E
Sbjct: 676 DAGAPGERGPPGLAGAPGLRGGAGPP-GPEGGKGAAGPPGPPGAAGTPGLQGMPGE 730



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 119/417 (28%), Positives = 146/417 (35%), Gaps = 70/417 (16%)

Query: 62  PKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDS 121
           P   G  G  G  G  G  G  G  G  G  G  GPPG  G      P     A +D +S
Sbjct: 179 PGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGP-----AGKDGES 233

Query: 122 GGSRPPLLPPGGRSTSAKP-FSPPSGPGRFPVPSPGHR--SGPPEPQRNRMPPPRPDVGS 178
           G  RP    PG R     P    P+G   FP    GHR   G    +     P       
Sbjct: 234 G--RPG--RPGERGLPGPPGIKGPAGIPGFP-GMKGHRGFDGRNGEKGETGAPGLKGENG 288

Query: 179 KPDSIPPPVPSTPRPIQSSPHNRGSPPVPG--GPR--------QPSPGPTPPP----FPG 224
            P     P P  PR    +P  RG P +PG  G R           PGP  PP    FPG
Sbjct: 289 LPGENGAPGPMGPR---GAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPG 345

Query: 225 NRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVP- 283
           + G A G      SP S+ +P     P P   + A   + PP PP +   P    E  P 
Sbjct: 346 SPG-AKGEVGPAGSPGSNGAPGQRGEPGPQGHAGA---QGPPGPPGINGSPGGKGEMGPA 401

Query: 284 -------------PPPP--QNNKPPV---PSTPRPSASSQAPPPPPPPSRPGPPPLP--P 323
                        PP P   N  P +      P  + +   P P       G P +P   
Sbjct: 402 GIPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAK 461

Query: 324 SSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPP--PSERPPPPVRDPPGRSGPLPP 381
              G D +P  P  N  L  +     +PG  GP  P   P E+ P   R  PG +GP   
Sbjct: 462 GEDGKDGSPGEPGAN-GLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGA 520

Query: 382 PPPVSRNGSTS----RALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPS 434
                R+G       R +P +P  P   G        +P  P  +  +G P PP PS
Sbjct: 521 AGEPGRDGVPGGPGMRGMPGSPGGPGSDG--------KPGPPGSQGESGRPGPPGPS 569



 Score = 87.0 bits (214), Expect = 4e-17
 Identities = 114/405 (28%), Positives = 135/405 (33%), Gaps = 70/405 (17%)

Query: 66   GAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGL----GGLFQAGMPKLRSTANRDNDS 121
            G  G  G  G  G  GG G  G  G  G GGPPG+    GG   AG P  +         
Sbjct: 807  GPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGERGSP 866

Query: 122  GGSRPPLLPPGGRSTSAKPFSP--PSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            GG      P G R     P S   P  PG  P  SPG + GPP P  N   P  P V   
Sbjct: 867  GGPGAAGFP-GARGLPGPPGSNGNPGPPG--PSGSPG-KDGPPGPAGNTGAPGSPGV--- 919

Query: 180  PDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSP----GPT-------PPPFPGNRGT 228
                     S P+     P  +GSP   G P  P P    G T       PP  PG RG+
Sbjct: 920  ---------SGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAGPPGMPGPRGS 970

Query: 229  ALGGGSIRQSPLSSSSPFSNR--PPLPP-TPSRALDDKPPPPPPPVGNRPSIHREAVP-- 283
                G   +S    ++  S    PP P   P  A     P      G+     R+  P  
Sbjct: 971  PGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGG 1030

Query: 284  ------------PPPPQNNKPPVPSTPRPSASSQ--------APPPPPPPSRPGPPPLPP 323
                        P  P +  PP P  P   +  +        A  P P  SR  P P  P
Sbjct: 1031 KGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQGP 1090

Query: 324  SSSGNDETPR-----LPQRNLSLSSSTPPLPSP-GRSGPL--PPPPSERPPPPVRDPPGR 375
                 +   R        R    +   P  P P G+ G +  P P   R P     PPG+
Sbjct: 1091 RGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGK 1150

Query: 376  SG----PLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP 416
             G    P P  PP  R     R    +P  P + G   P   P P
Sbjct: 1151 DGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGP 1195



 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 91/318 (28%), Positives = 103/318 (32%), Gaps = 75/318 (23%)

Query: 56   APILDKPKG-AGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGG-LFQAGMPKLRS 113
            +P  D P G AG  G  G  G  G  G  G  G  GS G  GPPG  G L  AG+   R 
Sbjct: 898  SPGKDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARG 957

Query: 114  TANRDNDSGGSRPPLLPPGGRSTSAKPFSP-------PSGPGRFP-----VPSPGHRSGP 161
             A      G    P  P G +  S KP +        P GP   P        PG    P
Sbjct: 958  LAGPPGMPGPRGSPG-PQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNP 1016

Query: 162  PE---PQRNRMPPPRPDVGSKPDSIPPPVPSTPRPI-------------QSSPHNRGSPP 205
                 P R+  P  + D G       P  P  P P              +S P      P
Sbjct: 1017 GSDGLPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAP 1076

Query: 206  VPGGPRQPSPGPTPPP-------------------FPGNRGTALGGGSI-RQSPLSSSSP 245
             P G R  +PGP  P                    FPGN G     G   +Q  + S  P
Sbjct: 1077 GPAGSRG-APGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGP 1135

Query: 246  FSNRPPLPPTPSRALDDK-----PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300
               R P+ P+     D       P  PP P GNR     E  P  P Q            
Sbjct: 1136 AGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQ------------ 1183

Query: 301  SASSQAPPPPPPPSRPGP 318
                  P PP PP  PGP
Sbjct: 1184 ------PGPPGPPGAPGP 1195



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 80/282 (28%), Positives = 96/282 (34%), Gaps = 45/282 (15%)

Query: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGP-RQPSPG-PTPPPFPGNRGTALGGGSIRQSPLS 241
           PP  P+ P   Q     +G P  PG P R   PG P  P  PG+ G      S    P +
Sbjct: 91  PPTAPTRPPNGQGPQGPKGDPGPPGIPGRNGDPGIPGQPGSPGSPGPPGICESCPTGPQN 150

Query: 242 SSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPS 301
            S  + +           L   P P  PP            P PP  +  P  P +P   
Sbjct: 151 YSPQYDSYDVKSGVAVGGLAGYPGPAGPP----------GPPGPPGTSGHPGSPGSP--- 197

Query: 302 ASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP 361
              Q PP  P  + P  PP PP + G       P         +     PG  G LP PP
Sbjct: 198 -GYQGPPGEPGQAGPSGPPGPPGAIG-------PSGPAGKDGESGRPGRPGERG-LPGPP 248

Query: 362 SERPPPPVRDPPGRSGPLPPPPPVSRNGST-SRALPATPQLPSRSGVD---SPRSGP--- 414
             + P  +   PG  G           G T +  L     LP  +G      PR  P   
Sbjct: 249 GIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMGPRGAPGER 308

Query: 415 -RPPLP---------PDRPSAGAP-PPPPPSTSIRNGFQDSP 445
            RP LP           R S G P PP PP T+   GF  SP
Sbjct: 309 GRPGLPGAAGARGNDGARGSDGQPGPPGPPGTA---GFPGSP 347



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 57/175 (32%), Positives = 64/175 (36%), Gaps = 10/175 (5%)

Query: 62   PKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDS 121
            P   GA G  G  G  G  G  G  G  G  G  G PG  G   A  P+       D   
Sbjct: 1040 PGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAGSRGAPGPQ---GPRGDKGE 1096

Query: 122  GGSRPPLLPPGGRSTSAKPFSPPS-GPG--RFPVPSPGHRSGPPEPQRNRMPPPRPDVGS 178
             G R      G R     P +P S GP   +  + SPG  +GP  P     PP +     
Sbjct: 1097 TGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGP-AGPRGPVGPSGPPGKDGTSG 1155

Query: 179  KPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGG 233
             P  I PP P   R  + S    GSP  PG P  P P   P P  G  G A   G
Sbjct: 1156 HPGPIGPPGPRGNRGERGS---EGSPGHPGQPGPPGPPGAPGPCCGGVGAAAIAG 1207



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 44/162 (27%), Positives = 53/162 (32%), Gaps = 33/162 (20%)

Query: 293 PVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLP--- 349
           P P  P     +  P PP  P+RP     P    G+   P +P RN       P +P   
Sbjct: 75  PNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRN-----GDPGIPGQP 129

Query: 350 -SPGRSGP------LPPPPSERPPP-------------PVRDPPGRSGPLPPPPPVSRNG 389
            SPG  GP       P  P    P               +   PG +GP  PP P   +G
Sbjct: 130 GSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTSG 189

Query: 390 STSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPP 431
                 P +P  P   G         P  PP  P A  P  P
Sbjct: 190 H-----PGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGP 226



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 56/186 (30%), Positives = 71/186 (38%), Gaps = 31/186 (16%)

Query: 265 PPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLP-- 322
           P P  P G   ++     P PP    +P  P+   P      P PP  P R G P +P  
Sbjct: 75  PNPEIPFGECCAV----CPQPPTAPTRP--PNGQGPQGPKGDPGPPGIPGRNGDPGIPGQ 128

Query: 323 PSSSGNDETPRLPQ------RNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRS 376
           P S G+   P + +      +N S    +  + S    G L   P    PP    PPG S
Sbjct: 129 PGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPGPPGPPGTS 188

Query: 377 G-PLPPPPPVSRN--GSTSRALPATPQLPSRSGVDSPRSGP--------RPPLPPDRPSA 425
           G P  P  P  +   G   +A P+ P  P   G   P SGP        RP  P +R   
Sbjct: 189 GHPGSPGSPGYQGPPGEPGQAGPSGP--PGPPGAIGP-SGPAGKDGESGRPGRPGER--- 242

Query: 426 GAPPPP 431
           G P PP
Sbjct: 243 GLPGPP 248



 Score = 31.6 bits (70), Expect = 1.8
 Identities = 41/170 (24%), Positives = 56/170 (32%), Gaps = 32/170 (18%)

Query: 341 LSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQ 400
           L    P +P        P PP+     P R PP   GP  P           +  P  P 
Sbjct: 72  LDCPNPEIPFGECCAVCPQPPTA----PTR-PPNGQGPQGP-----------KGDPGPPG 115

Query: 401 LPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQD-SPCEDEWESR------ 453
           +P R+G         P +P    S G+P PP    S   G Q+ SP  D ++ +      
Sbjct: 116 IPGRNG--------DPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVG 167

Query: 454 -FYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPIP 502
               +P    PP  P    T  +P        +       +  P  PP P
Sbjct: 168 GLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGP 217


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score =  115 bits (288), Expect = 9e-26
 Identities = 139/529 (26%), Positives = 179/529 (33%), Gaps = 87/529 (16%)

Query: 5    PPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKG 64
            PP A PP P  + A T  P    T  A                 T+ + +  P     KG
Sbjct: 1035 PPAATPPSPKGSPAATPLPKGAPTTPAA----------------TLPSPKGGPATPSLKG 1078

Query: 65   AGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLF---QAGMPKLRSTANRDNDS 121
            A            GG       G         P   GGL      G P   +        
Sbjct: 1079 APTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKG 1138

Query: 122  GGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPD 181
            G + PP  P G  +T A   +PPS  G    P P  +  P  P      PP P  G    
Sbjct: 1139 GLATPP--PKGAPTTPAA--TPPSPKGGLATPPP--KGAPTTPAAT---PPSPKGGLATP 1189

Query: 182  SIPPPVPSTPRPIQSSPHNRGSPPVP-GGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL 240
            S P   P+TP     SP    + P P G P  P+  P  P           GG    SP 
Sbjct: 1190 S-PKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK----------GGLATPSPK 1238

Query: 241  SSSSPFSNRPPLPPTPSRALDDKPPP---PPPPVGNRPSIHREAVPPP-----------P 286
             + +  +  PP P    +     PPP   P PP    PS+      PP           P
Sbjct: 1239 GAPTTPAATPPSP----KGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTP 1294

Query: 287  PQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTP 346
            P     P  S P+ + +  A  PP P   PG PP   + +    TP  P+   +L ++TP
Sbjct: 1295 PSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTP 1354

Query: 347  PLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSG 406
                  + GP  P   E P PP   P  + GP   PP   R      A+P+    P+   
Sbjct: 1355 S----SKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKR----GPAIPSPKGDPTSPA 1406

Query: 407  VD--SPRSGPRPPLPPD---RPSAGAPPPP---------PPSTSIRNGFQDSPCEDEWES 452
            V   SP+  P  P+  +    PS G   PP          P+TS   G   +P      +
Sbjct: 1407 VIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPT 1466

Query: 453  RFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPI 501
                 P S   PP P    T S P K       + +     GAP LP +
Sbjct: 1467 LPAVTPPSPKEPPAPKQVATSSSPKK-------APATPAPMGAPTLPAV 1508



 Score =  104 bits (260), Expect = 2e-22
 Identities = 105/374 (28%), Positives = 137/374 (36%), Gaps = 72/374 (19%)

Query: 109  PKLRSTANRDNDSGGSRPPLLP-------------PGGRSTSAKPFSP-PSGPGRFPVPS 154
            P  + +A  D   G    P+ P              G + + A   SP P  P   P PS
Sbjct: 809  PTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPS 868

Query: 155  PGHRSGPPEPQRNRMPP---PRPDVGSKPDSIPPPVPSTPRPIQ--------SSPHNRGS 203
                  P  P+   +PP   P P V + P   P   P+TP P Q        SSP    +
Sbjct: 869  A---VTPLSPKGVTLPPKETPTPSVVNLP--FPKEGPATPAPKQAPALSMTSSSPKKARA 923

Query: 204  PPVPGG-PRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDD 262
             P P G P  PSP   P P P     +  GG    SP  + +P +  PP P         
Sbjct: 924  TPAPKGIPASPSPKGAPTP-PAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSP 982

Query: 263  KPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPG----- 317
            K  P PP           A  PP P+      P+TP P  +   PP   PPS  G     
Sbjct: 983  KGAPTPP-----------AATPPSPKGG----PATPSPKGAP-TPPAVTPPSPKGSPAAT 1026

Query: 318  ---------PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGP----LPPPPSER 364
                     P   PPS  G+     LP+   +  ++T P P  G + P     P PP+  
Sbjct: 1027 PFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT 1086

Query: 365  PPPP---VRDPPGRSGPLPP--PPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLP 419
            PP P      P  +  P+PP   PP  + G  +      P  P+ +   SP+ G   P P
Sbjct: 1087 PPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAAT-PPSPKGGLATPPP 1145

Query: 420  PDRPSAGAPPPPPP 433
               P+  A  PP P
Sbjct: 1146 KGAPTTPAATPPSP 1159



 Score =  100 bits (250), Expect = 2e-21
 Identities = 139/564 (24%), Positives = 190/564 (33%), Gaps = 93/564 (16%)

Query: 5    PPPAPPPPPTFALANTEKP----TLNKTEQAGRNALLSDISKGKKLKKTVT--NDRSAPI 58
            PP A PP P   LA         T   T  + +  L +   KG       T  + +    
Sbjct: 1105 PPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLA 1164

Query: 59   LDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRST--AN 116
               PKGA            GG       G   +     P   GGL         +T  A 
Sbjct: 1165 TPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAAT 1224

Query: 117  RDNDSGGSRPPLLPPGGRST-SAKPFSPPSGPGRFP---VPSP---------GHRSGPPE 163
              +  GG   P  P G  +T +A P SP  GP   P    P+P         G  + PP 
Sbjct: 1225 PPSPKGGLATPS-PKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPH 1283

Query: 164  ---PQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPP 220
               P    + PP P  G  P + PP    TP P  + P  +GSP  P     P+P    P
Sbjct: 1284 KGAPNPAVVTPPSPKGG--PATSPPKGAPTP-PAATPPSPKGSPGTPPPKGAPTPPAVTP 1340

Query: 221  PFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPP--TPSRALDDKPPPPPPPVGNRPSIH 278
            P P  +GT     +   S    ++P S   P PP  TPS        PP P  G      
Sbjct: 1341 PSP--KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRG------ 1392

Query: 279  REAVPPPPPQNNKPPV--------PSTP-------RPSASSQAPPP-------------- 309
              A+P P      P V        P+TP        PS     PP               
Sbjct: 1393 -PAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSA 1451

Query: 310  ----PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSS--STPPLPSPGRSGPLPPPPSE 363
                P  PS  G P LP  +  + + P  P++  + SS    P  P+P  +  LP     
Sbjct: 1452 PKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPS 1511

Query: 364  RPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRP 423
             P      P  R  P+ P   +    + +   P    +P    V SP+  P  P P + P
Sbjct: 1512 SPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAP 1571

Query: 424  S------AGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPS 477
            +      A +PP   PST     ++ +P   E        P    P P    +   + P+
Sbjct: 1572 ATPSSKEASSPPAVTPST-----YKGAPSPKE----LLIPPAVTSPSP----KEAPTPPA 1618

Query: 478  KLARNESRSGSNRRERGAPPLPPI 501
                +  +  +    +G P  PP+
Sbjct: 1619 VTPPSPEKGPATPAPKGTPTSPPV 1642



 Score = 85.9 bits (211), Expect = 8e-17
 Identities = 83/306 (27%), Positives = 110/306 (35%), Gaps = 34/306 (11%)

Query: 153  PSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSS--PHN-------RGS 203
            PSP   S  P+ +R    PP     + PD+    + S   P+++S  P N       + S
Sbjct: 794  PSPLGVSVSPQTKR----PPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDS 849

Query: 204  PPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDK 263
            P     P  PSP   P P   +  T L    +   P  + +P     P P         K
Sbjct: 850  PATTHSPTPPSPKGAPTP---SAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPK 906

Query: 264  PPPPPPPVGNRPSIHREAVPPPP-----PQNNKPPVPSTPRPSASSQAPPPPPPPSRPGP 318
              P      + P   R A P P      P     P P    P +    P  P P   P P
Sbjct: 907  QAPALSMTSSSPKKAR-ATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTP 965

Query: 319  PPL-PPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGP----LPPPPSERPPPPVRD-- 371
            P   PPS  G   TP  P+   +  ++TPP P  G + P     P PP+  PP P     
Sbjct: 966  PAATPPSPKGGPATPS-PKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPA 1024

Query: 372  ----PPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGA 427
                P G S P    PP  +    +  LP        + + SP+ GP  P     P+  A
Sbjct: 1025 ATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPA 1084

Query: 428  PPPPPP 433
              PP P
Sbjct: 1085 ATPPSP 1090



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 109/418 (26%), Positives = 142/418 (33%), Gaps = 81/418 (19%)

Query: 128  LLPPGGRSTSAKPFSPPSG--PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSI-- 183
            +L P    +   P  PP+G  PG   V    H S       +    P  D G+   +   
Sbjct: 725  VLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSK 784

Query: 184  ---------PPPV-----PSTPRPIQSSPHNRGS--PPVPGGPRQPSPGPTPPPFPGNRG 227
                     P P+     P T RP    P  +GS  P  P G       P    F     
Sbjct: 785  GTLTYLADSPSPLGVSVSPQTKRP----PTKKGSAGPDTPIGNLSSPVSPVEASFLPENS 840

Query: 228  TALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKP-----PP---PPPPVGNRPSIHR 279
             +  G   + SP ++ SP    P   PTPS      P     PP   P P V N P   +
Sbjct: 841  LSFQGS--KDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLP-FPK 897

Query: 280  EAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPP--PLPPSSSGNDETPRLPQR 337
            E    P P+       ++  P  +   P P   P+ P P   P PP++     TP  P+ 
Sbjct: 898  EGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAA-----TPPSPKG 952

Query: 338  NLSLSSSTPPLPSPGRSGPLPP---PPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRA 394
                    P  PSP +  P PP   PPS +  P    P G   P    PP  + G     
Sbjct: 953  G-------PATPSP-KWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPPSPKGG----- 999

Query: 395  LPATPQLPSRSGVDSPRSGPRPPLPPDRPSA-----GAPPPP---PPSTSIRNGFQDSPC 446
                P  PS  G  +P     PP P   P+A     GA  PP   PPS       + SP 
Sbjct: 1000 ----PATPSPKGAPTP-PAVTPPSPKGSPAATPFPKGASTPPAATPPSP------KGSPA 1048

Query: 447  EDEWESRFYFHPISDLPPPE--PYVQTTKSYPSKLARN--ESRSGSNRRERGAPPLPP 500
                       P + LP P+  P   + K  P+  A      + G         P+PP
Sbjct: 1049 ATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPP 1106



 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 109/457 (23%), Positives = 159/457 (34%), Gaps = 115/457 (25%)

Query: 122  GGSRPPLLPPGGRSTSAKPFSPPSGPGR--------FPVPSPGHRSGPPEPQR------N 167
            G   PP + P     +    +P  GP           P  +P     PP P++       
Sbjct: 1431 GDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSP 1490

Query: 168  RMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGG------------PRQ--- 212
            +  P  P     P ++P  +PS+P+ + ++P +R  P  P              P++   
Sbjct: 1491 KKAPATPAPMGAP-TLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALI 1549

Query: 213  ------PSPGPTPP-PFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP 265
                  PSP  TP  P P            +++P + SS  ++ PP   TPS     K  
Sbjct: 1550 PPAMTVPSPKKTPAIPTP------------KEAPATPSSKEASSPPAV-TPSTY---KGA 1593

Query: 266  PPP-----PPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPP 320
            P P     PP    PS      PP     +    P+TP P  +  +PP  P   +    P
Sbjct: 1594 PSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDS--P 1651

Query: 321  LPPSSSGNDETPRLPQRNLSLSS-----------------STPPLPSPGRSGPLPPPPSE 363
              P+S        +PQ +  L +                 STP + +P R GP     S 
Sbjct: 1652 TSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSA 1711

Query: 364  RPPPPVRDPP---GRSGPL---PPPP--PVSRN------GSTSRALPATPQLPSRSGVDS 409
              PP   DP    G  GPL    P P  PV ++      G  +   P  P  P  S   +
Sbjct: 1712 TSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKAST 1771

Query: 410  PRSGP--RPPLP-PDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPE 466
            P +       LP P+  S  A P PP S  +                    P+  LPP +
Sbjct: 1772 PLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPS-----------------PVPTLPPKQ 1814

Query: 467  PYVQTTKSYPSKLARNESRSGSNRRERGAPPL-PPIP 502
             ++    S P  +  + S+  +   E    PL PP P
Sbjct: 1815 QFL---PSSPGLVLESPSKPLAPADEDELLPLIPPEP 1848



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 77/327 (23%), Positives = 114/327 (34%), Gaps = 49/327 (14%)

Query: 128  LLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPP-----RPDVGSKPDS 182
            L+PP    TS  P   P+ P   P PSP      P P+     PP       D  + P S
Sbjct: 1600 LIPPA--VTSPSPKEAPTPPAVTP-PSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPAS 1656

Query: 183  IPPPVPST-PRPIQSSPHNRGSPPVPGGPRQPSPGPTPP-PFPGNRGTALGGGSIRQSPL 240
            +   + +T P+  +  P  +G   +      P+P  TP    P  +G      S    P+
Sbjct: 1657 VTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPI 1716

Query: 241  --------SSSSPFSNRPPLPPTPSRALDDK-------------PPPPPPPVGNRP--SI 277
                     S  P S   P P  P +    K             P  PP    + P  + 
Sbjct: 1717 CPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAA 1776

Query: 278  HREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP------PSRPG----PPPLPPSSSG 327
              E V P P   +    PS P     + +P P  P      PS PG     P  P + + 
Sbjct: 1777 AFEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPAD 1836

Query: 328  NDE-TPRLPQRNLS----LSSSTPPLPSPGRSG-PLPPPPSERPPPPVRDPPGRSGPLPP 381
             DE  P +P   +S      S    +P+P  +G P+P P +++P        G       
Sbjct: 1837 EDELLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDE 1896

Query: 382  PPPVSRNGSTSRALPATPQLPSRSGVD 408
              P      +++A     QL + + +D
Sbjct: 1897 SVPELEEQDSTQATTQQAQLAAAAEID 1923



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 73/304 (24%), Positives = 102/304 (33%), Gaps = 65/304 (21%)

Query: 147 PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPV 206
           PG      P      P+PQ      P     S   ++  P P+ P P   +P        
Sbjct: 2   PGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAA 61

Query: 207 PGGPRQPSPG-----PTPPPFP-GNRGTALGGGSIRQSP---------------LSSSSP 245
                 PSP      P   PFP  + GTAL  G+  ++P               L+ +SP
Sbjct: 62  NQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASP 121

Query: 246 FSNRPPLPPTPSRAL---------------DDKPP-----PPPPPVGNRPSIHREAVP-- 283
               P L  TPS +                   PP     PP   V    S+   + P  
Sbjct: 122 MI-APTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIA 180

Query: 284 PPPPQNNKPPVPSTPRPSASSQAPPP------------PPPPSRPGPPPLP---PSSSGN 328
           P  P+ N   VPS   P+      PP            P    + G   LP   P+++  
Sbjct: 181 PSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLA 240

Query: 329 DETPRLPQRNLSLSSSTPPLP-SPGRSGPLPPPP----SERPPPPVRDPPGRSGPLPPPP 383
             +P++    +S    +P  P S    GP+ PP     S +  P V      +GP  PP 
Sbjct: 241 IASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPD 300

Query: 384 -PVS 386
            P+S
Sbjct: 301 FPIS 304



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 81/367 (22%), Positives = 121/367 (32%), Gaps = 52/367 (14%)

Query: 93  GGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPP---------LLPPGGRSTSAKPFSP 143
           G   PP    L    +P + S+      +G + PP         L P    S  +     
Sbjct: 268 GPVSPPAALSLSTQSLPVVTSS---QKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLG 324

Query: 144 PSGPGRFPVP-----SPGHRS-GPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSS 197
            +GP     P     S  H S G   P +  + PP P   S+ + +P  V + P      
Sbjct: 325 QTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPPLP---SRNEVVPATVAAFPVV---- 377

Query: 198 PHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLP---P 254
                +P V  GP   S     P    N  T+          L SS   +   PL    P
Sbjct: 378 -----APSVDKGPSTISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMP 432

Query: 255 TPSRALDDKPPPPPPPVGNRPSIHRE-AVPPPPPQNNKPPVPSTPR-PSASSQAPPPPPP 312
             S          P  +   P+   E A    PP ++ P     P  P+A   AP  P  
Sbjct: 433 VSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAPVAPKE 492

Query: 313 PSR--------PGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS-PGRSGPLPPPPSE 363
           PS         P  PPLP      ++   LP   L    +   L + P      P  P++
Sbjct: 493 PSTQVATTLRIPVSPPLPDP----EDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQ 548

Query: 364 RPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRP 423
                 +DP      LP      +N  + ++  ++P++P        +     PLP  +P
Sbjct: 549 AGLTTKKDPT----VLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKP 604

Query: 424 SAGAPPP 430
           ++    P
Sbjct: 605 ASSMTSP 611



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 71/295 (24%), Positives = 103/295 (34%), Gaps = 46/295 (15%)

Query: 91  SFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPP---LLPPGGRSTSAKPFSPPSGP 147
           SFG     G  G      P +++ +   + +G S P    ++PP      ++    P+  
Sbjct: 316 SFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRSVIPP----LPSRNEVVPATV 371

Query: 148 GRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVP 207
             FPV +P    GP         P      +   S+ P   +T   ++SSP+     P+ 
Sbjct: 372 AAFPVVAPSVDKGPSTISSITCSPSGSLNVATSFSLSP---TTSLILKSSPNATYHYPLV 428

Query: 208 GGPRQPSPGPTP-----PPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDD 262
                 S G TP     P       T     +   SP  SS P SN   + PT   AL  
Sbjct: 429 AQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSPPMSSGPISN---IEPTSPAALVM 485

Query: 263 KPPPPPPPVGNRPSIHREAVPPP------------------PPQNNKPPVPSTPR--PSA 302
            P  P  P     +  R  V PP                  P Q +   VP++    P +
Sbjct: 486 APVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFS 545

Query: 303 SSQA------PPPPPPPSRPGPPPLPP--SSSGNDETPRLPQRNLSLSSSTPPLP 349
            +QA       P   P  +  P   P   S+S + E P  P+  L+  S   PLP
Sbjct: 546 PAQAGLTTKKDPTVLPLVQAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLP 600



 Score = 31.2 bits (69), Expect = 2.3
 Identities = 31/122 (25%), Positives = 45/122 (36%), Gaps = 6/122 (4%)

Query: 280 EAVPPPPPQNNKPPVPSTPRPSASSQAPPPP-PPPSRPGPPPLPPSSSGNDETPRLPQRN 338
           + +P P  +    P+ S    +A+   P P  PPP  P P   P S++        P  +
Sbjct: 14  QELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQAS----PFPS 69

Query: 339 LSLSSSTP-PLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPA 397
            S  +STP  +P P  S     P    P  P   P     P+ P      +   +  L  
Sbjct: 70  PSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPTLKG 129

Query: 398 TP 399
           TP
Sbjct: 130 TP 131



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 34/132 (25%), Positives = 46/132 (34%), Gaps = 18/132 (13%)

Query: 320 PLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRS--- 376
           PL P++S N      PQ   +  ++    P   +S P P  P    PP  +   G S   
Sbjct: 699 PLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAGTPPGTKKVDGISHTS 758

Query: 377 --GPLPPPP---PVSRNGSTSRA-----LPATPQLPSRSGVDSPRSGPRPPLP-----PD 421
              P+   P   P   +G+++ A     L      PS  GV       RPP       PD
Sbjct: 759 ALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPD 818

Query: 422 RPSAGAPPPPPP 433
            P      P  P
Sbjct: 819 TPIGNLSSPVSP 830


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score =  115 bits (287), Expect = 1e-25
 Identities = 117/382 (30%), Positives = 155/382 (40%), Gaps = 79/382 (20%)

Query: 115 ANRDNDSGGSRPPLLPPGGRS--TSAKPFSPP--SGPGRFPVP-SPGHRSGPPEP--QRN 167
           A R   +GG    L  P  RS  +SA P S P  SGP     P +P H S P     Q  
Sbjct: 224 ARRRPSAGGG---LQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQAL 280

Query: 168 RMP---PPRPD-------VGSKPDSIPPPVPS----TPRPIQSSPHNRG----------- 202
           R P   PPR D       + S P + P P  +     P  + ++PH+             
Sbjct: 281 RPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPL 340

Query: 203 SPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDD 262
           +PP P  P      P+PP  P ++ T     S+    L ++  F   PPL P  +     
Sbjct: 341 APPSPSAPPSLQTLPSPPATPPSQATT----SLGSPTLQATHSFLPSPPLSPLAT----- 391

Query: 263 KPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASS----QAP--PPPPPP--- 313
            PPP  PP    P +     PP  P  +    PS   P+A +    QAP  PPP PP   
Sbjct: 392 -PPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQA 450

Query: 314 --SRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPL---PSPGRSGPLPPP--PSERPP 366
             S P  PP+ PS++   + P         S + PPL   PSP  S P+ P   P  + P
Sbjct: 451 PFSPPASPPVSPSATPPSQAPP--------SLAAPPLQVPPSPPASPPMSPSATPPPQAP 502

Query: 367 PPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQ--------LPSRSGVDSPRSGPRPPL 418
           PP+  PP +    PP  P +      +ALP+ P          PS S   SP + P P  
Sbjct: 503 PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQA 562

Query: 419 PP--DRPSAGAPPPPPPSTSIR 438
           PP    P    PP PP S +++
Sbjct: 563 PPVLAAPLLQVPPSPPASPTLQ 584



 Score =  102 bits (255), Expect = 6e-22
 Identities = 114/386 (29%), Positives = 138/386 (35%), Gaps = 51/386 (13%)

Query: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGS--KPDSI 183
           P L  P  ++  + P SPP  P   P P   +       Q    PPP P V +   P + 
Sbjct: 398 PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 457

Query: 184 PPPVPSTPRPIQSSPHNRGSPPV---PGGPRQP--SPGPTPPPFPGNRGTALGGGSIRQS 238
           PP  PS   P Q+ P +  +PP+   P  P  P  SP  TPPP               Q+
Sbjct: 458 PPVSPSATPPSQAPP-SLAAPPLQVPPSPPASPPMSPSATPPP---------------QA 501

Query: 239 PLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTP 298
           P          PPL   P +    KPPP  PP    P +     PP       P  PS  
Sbjct: 502 P----------PPLAAPPLQLA--KPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS 549

Query: 299 RPSASSQAPPPPPPPSRPGP----PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRS 354
            P +    PPP  PP    P    PP PP+S       R P      S S P L      
Sbjct: 550 LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP 609

Query: 355 GPLPPPPSERPPPPVRDP--PGRSGPLPPPPPVSR--NGSTSRALPATPQLPSRSGVDSP 410
           GP PPPPS  P   +  P   G S      P   R  +        A+P   +      P
Sbjct: 610 GP-PPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHP 668

Query: 411 RSGPRPPLPP--DRPSAGAPPPPPPSTSIRNGFQDSPC---EDEWESRFYFHPISDLPPP 465
            +  R P PP   R + GAP P PP+T    G  D  C   E E        P +  P P
Sbjct: 669 AAWSRGPAPPLAFRGAPGAPLPWPPATG--PGSADGLCTIYETEGPESATPAPGALDPGP 726

Query: 466 EPYVQTTKSYPSKLARNESRSGSNRR 491
            P     K+     A   SRS    R
Sbjct: 727 SPGTSGGKAAAGAGAGASSRSPKQAR 752



 Score = 96.7 bits (239), Expect = 4e-20
 Identities = 125/447 (27%), Positives = 157/447 (35%), Gaps = 103/447 (23%)

Query: 70  GGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLL 129
           G  G  G        GG GG +     P       +AG  +   T++R+     SRPP  
Sbjct: 48  GAAGAVGRKPLAERAGGIGGATIPESAP-------RAGPTRSAGTSSRNP---ASRPPAS 97

Query: 130 PPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQ------------------RNRMPP 171
             G R+  AK  SP       PV SPG  SG   P                   +    P
Sbjct: 98  GRGERAPPAKNTSPG------PVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAP 151

Query: 172 PRP--DVGSKPDSIPP----PVPSTPRPIQSSPHNRGSP-PVPGG-PRQPSPGP------ 217
            R     G++ D+  P    P P+  R  +++    G P P P   PR P+ GP      
Sbjct: 152 KRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSS 211

Query: 218 ------TPPPFPGNRGTALGGG-------SIRQSPLSSSSPFSNRPPLPPTPSRALDDKP 264
                 T P     R  + GGG       S+  S    SSP  + P    TP        
Sbjct: 212 ASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ 271

Query: 265 PPPP------PPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP------ 312
           P P       PP    P   ++A P   P ++ P    +P  +  SQAPP  P       
Sbjct: 272 PKPKGLQALRPPQVTPP--RKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSS 329

Query: 313 ---------PSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPP-------LPSPGRSGP 356
                    P  P  P  PPS       P  P    + S  +P        LPSP  S P
Sbjct: 330 LTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLS-P 388

Query: 357 LPPPPSERPP----PPVRDPPG--RSGPLPP---PPPVSRNGSTSRALPATPQLPSRSGV 407
           L  PP + PP    PP++ PP    S PL P   P P + N      L A    P    V
Sbjct: 389 LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 448

Query: 408 DSPRSGPRPPLPPDRPSAGAPPPPPPS 434
            +P S P    PP  PSA  P   PPS
Sbjct: 449 QAPFSPPAS--PPVSPSATPPSQAPPS 473



 Score = 84.3 bits (207), Expect = 2e-16
 Identities = 130/462 (28%), Positives = 163/462 (35%), Gaps = 73/462 (15%)

Query: 97  PPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPG 156
           P  L  L  AG    +  A R    GG+  P   P    T +   S  +   R P    G
Sbjct: 41  PAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRG 100

Query: 157 HRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHN---RGS-------PPV 206
            R+    P +N  P P    G +      P P   + ++ S      RG          +
Sbjct: 101 ERA---PPAKNTSPGPVSSPG-RASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL 156

Query: 207 PGGPRQPSPGP---TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLP---PTPSRAL 260
             G R+ + GP   TP P    R  A G       P  S+ P   RPP      + S A 
Sbjct: 157 SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARP---RPPTEGPRKSVSSAS 213

Query: 261 DDKPPPPPPPVGNRP------------SIHREAVPPPPPQNNKPPVPSTPRPSASSQAPP 308
           +     P P    RP            S+   A P   P  + P    TPR  A    P 
Sbjct: 214 EHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPK 273

Query: 309 P-------PP---PPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPP-LPSPGRSG-- 355
           P       PP   PP +   P L P SS    T   P  + +L S  PP LP+   S   
Sbjct: 274 PKGLQALRPPQVTPPRKDAAPALGPLSSSPLAT---PSPSAALQSQAPPTLPATPHSSSL 330

Query: 356 ------PLP-PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQ-LPSRSGV 407
                 PLP  PPS   PP ++  P    P   PP  +     S  L AT   LPS    
Sbjct: 331 TCQLATPLPLAPPSPSAPPSLQTLP---SPPATPPSQATTSLGSPTLQATHSFLPSPP-- 385

Query: 408 DSPRSGPRPPLPP--DRPSAGAPPPPPPSTSIRNGFQDSP-CEDEWESRFYFHPISDLPP 464
            SP + P P  PP    P   APP PP S  +      SP   +         P S  PP
Sbjct: 386 LSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFS--PP 443

Query: 465 PEPYVQTTKSYPSKLARNESRSGSNRR--ERGAPPL--PPIP 502
           P P VQ   S P+    + S +  ++      APPL  PP P
Sbjct: 444 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSP 485



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 107/409 (26%), Positives = 139/409 (33%), Gaps = 132/409 (32%)

Query: 210 PRQP-SPGPTPPPFP-----------------GNRGTALGGGSI----------RQSPLS 241
           PR P SP P PP  P                   R   +GG +I          R +  S
Sbjct: 27  PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTS 86

Query: 242 SSSPFSNRPP-------LPP----------TPSRALDDKPPPPPPPVGNRPSIH------ 278
           S +P ++RPP        PP          +P RA     P P    G R S        
Sbjct: 87  SRNP-ASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARG 145

Query: 279 -------REAVPPPPPQNNKPPVPSTPRPSASSQAP--------PPPPPPSRPGPP---- 319
                  R A+     ++   P P TP P+ + ++         P P P +RP PP    
Sbjct: 146 KATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGP 205

Query: 320 --------------PLP-----PSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGP---- 356
                         P P     PS+ G  + P     + SLSSS  PL SP RSGP    
Sbjct: 206 RKSVSSASEHSTTEPSPAARRRPSAGGGLQRP----ASRSLSSSATPLSSPARSGPSARG 261

Query: 357 ---LPPPPSE---------RPP---PPVRDPPGRSGPL------PPPPPVSRNGSTSRAL 395
               P  PS+         RPP   PP +D     GPL       P P  +        L
Sbjct: 262 TPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTL 321

Query: 396 PATP---QLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWES 452
           PATP    L  +     P + P P  PP   +  +PP  PPS +  +    SP      S
Sbjct: 322 PATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTS--LGSPTLQATHS 379

Query: 453 RFYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPI 501
                P+S L  P P      + P   A     +        +PPL P+
Sbjct: 380 FLPSPPLSPLATPPPQAPPALALPPLQAPPSPPA--------SPPLSPL 420



 Score = 29.6 bits (65), Expect = 6.7
 Identities = 26/90 (28%), Positives = 34/90 (37%), Gaps = 8/90 (8%)

Query: 2   PVPPPPAP------PPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRS 55
           P    PAP      P P T             + ++ + A L ++  G      V +  S
Sbjct: 712 PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLS 771

Query: 56  APILDKPKGAGAGGGGGGFGG--GGGFGGG 83
             +L       AGG GGG GG  GGG  GG
Sbjct: 772 RTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 801



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 14/25 (56%), Positives = 14/25 (56%)

Query: 65  AGAGGGGGGFGGGGGFGGGGGGGGG 89
           A A G  GG GGG G   GGG  GG
Sbjct: 777 AAAEGAAGGSGGGPGGAEGGGVTGG 801



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 13/26 (50%), Positives = 13/26 (50%)

Query: 75  GGGGGFGGGGGGGGGGSFGGGGPPGL 100
           G  GG GGG GG  GG   GG    L
Sbjct: 781 GAAGGSGGGPGGAEGGGVTGGARAAL 806


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
           sapiens]
          Length = 5537

 Score =  114 bits (286), Expect = 2e-25
 Identities = 114/385 (29%), Positives = 145/385 (37%), Gaps = 71/385 (18%)

Query: 127 PLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPP 186
           PLLPP   S    P SPP      P  SP   + PP P+ +R+ PP  ++ + P    P 
Sbjct: 439 PLLPPPEES----PLSPP------PEESP---TSPP-PEASRLSPPPEELPASP---LPE 481

Query: 187 VPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPF 246
                RP++ SP    SPP    P  P P  +P               + +SPLS     
Sbjct: 482 ALHLSRPLEESPL---SPPPEESPLSPPPESSP------------FSPLEESPLS----- 521

Query: 247 SNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306
              PP    PS AL+    PPP      P      + PPP +     +P++P P AS  +
Sbjct: 522 ---PPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPEE-----LPTSPPPEASRLS 573

Query: 307 PPPPPPPSRPGPP--PLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSER 364
           PPP   P  P P   P+ P    +   P   +  LS      PL  P  +  L PPP + 
Sbjct: 574 PPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDS 633

Query: 365 P--PPPVRDP---PGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLP 419
           P  PPP   P   P     L P P VSR        P +P  P  S    P    R   P
Sbjct: 634 PMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPP-PEESPTSPPPEASRLSPP 692

Query: 420 PDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLP----PPEPYVQTTKSY 475
           P+     +P  PPP        +DSP     E      P+ + P    P EP +      
Sbjct: 693 PE----DSPTSPPP--------EDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEG 740

Query: 476 PSKLARNESRSGSNRRERGAPPLPP 500
           P    R E    S R E   P L P
Sbjct: 741 PHLSPRPEEPHLSPRPEE--PHLSP 763



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 119/392 (30%), Positives = 142/392 (36%), Gaps = 61/392 (15%)

Query: 127 PLLPPGGRSTSAKPF-----SPPSGPGRFPVPSP--GHRSGPPEPQRNRMPPPRPDVGSK 179
           PL PP   S  + PF     SPP  P   P   P    R  PP  +    PPP     S 
Sbjct: 535 PLSPPPEASPLSPPFEESPLSPP--PEELPTSPPPEASRLSPPPEESPMSPPPEESPMSP 592

Query: 180 P---DSIPPPVPSTP--RPIQSSP------HNRGSPPVPGGPRQPSP--GPTPPPFPGNR 226
           P     + PP   +P   P + SP       +R SPP    P  P P   P  PP   +R
Sbjct: 593 PPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSR 652

Query: 227 GTALGGGSIRQSPLSSSSPFSNRPPLPPT--PSRALDDKPPPPPPPVGNRPSIHREAVPP 284
            + L   S R SP    SP S  P   PT  P  A    PPP   P    P     A PP
Sbjct: 653 LSPLPVVS-RLSPPPEESPLSPPPEESPTSPPPEASRLSPPPEDSPTSPPPE-DSPASPP 710

Query: 285 PP------PQNNKP--PVPSTPRPSASSQAPPPPPPPSRP--GPPPLPPSSSGNDETPRL 334
           P       P    P  P+P  P+    S+ P   P P  P   P P  P  S   E P L
Sbjct: 711 PEDSLMSLPLEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHL 770

Query: 335 -PQRNLSLSSSTPPLP--SPGRSGP-LPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGS 390
            PQ       + P  P  SP   GP L P P E    P  + P  S P+P  P +S    
Sbjct: 771 SPQPEEPCLCAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLS-PVPEEPCLSPQPE 829

Query: 391 TSRALPAT--PQLPSR-------SGVDSPRSGPRPPLPPDRPSAGAPP------PPPPST 435
            S   P +  P L  R         ++ P   PRP  PP+ P     P      PPP   
Sbjct: 830 ESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEP 889

Query: 436 SIRNGFQDSPCEDEWESRFYFHPISDLPPPEP 467
           S+     +    +  E      P+S LP   P
Sbjct: 890 SLSPLLGEPALSEPGEP-----PLSPLPEELP 916



 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 110/418 (26%), Positives = 138/418 (33%), Gaps = 66/418 (15%)

Query: 127 PLLPPGGRSTSAK---PFSPPSGPGRFPVPSPGHRSG---PPEPQRNRMPPPRPDVGSKP 180
           PL PP     S     P SPP  P   P+  P   S    PPE      PP    +   P
Sbjct: 519 PLSPPEESPPSPALETPLSPP--PEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPP 576

Query: 181 DSIPPPVPSTPRPIQSSPH-NRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSP 239
           +  P   P    P+   P  +R  PP    P  P P  +P   P          + R SP
Sbjct: 577 EESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPE--------ASRLSP 628

Query: 240 LSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPP--VPST 297
               SP S  PP   +P       PPP    +   P + R + PP     + PP   P++
Sbjct: 629 PPEDSPMS--PPPEESPM-----SPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTS 681

Query: 298 PRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP-QRNLSLSSSTPPLPSPGRSGP 356
           P P AS  +PPP   P+ P P   P S    D    LP + +  L     P   P   GP
Sbjct: 682 PPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSEGP 741

Query: 357 -LPPPPSE-----RPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS-GVDS 409
            L P P E     RP  P   P      L P P           L A P+ P  S   + 
Sbjct: 742 HLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQP-------EEPCLCAVPEEPHLSPQAEG 794

Query: 410 PRSGPRPP---LPPDRPSAGAPP-------PPPPSTSIRNGFQDSPCEDEWESRFYFHPI 459
           P   P+P    L P        P        P P  S  +   + PC        +  P 
Sbjct: 795 PHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLSPE 854

Query: 460 SDLPPPEPYVQTTKSYPSKLARNES---------------RSGSNRRERGAPPLPPIP 502
            + PP  P  +     P +    E                       E G PPL P+P
Sbjct: 855 LEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSPLP 912



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 79/282 (28%), Positives = 103/282 (36%), Gaps = 62/282 (21%)

Query: 213 PSPGPTPPPFPGN-----RGTALGGGSIRQSPLSSSSPFSNRPPL-------PPTPSRAL 260
           P PG TP   P       +G   GG      P           PL        P     L
Sbjct: 375 PEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPL 434

Query: 261 DDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPP 320
           +++ P  PPP         E+   PPP+ +    P++P P AS  +PPP   P+ P P  
Sbjct: 435 NEEMPLLPPP--------EESPLSPPPEES----PTSPPPEASRLSPPPEELPASPLPEA 482

Query: 321 LPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERP---------PPPVRD 371
           L                +LS      PL  P    PL PPP   P          PP   
Sbjct: 483 L----------------HLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEES 526

Query: 372 PPGRS--GPLPPPP---PVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAG 426
           PP  +   PL PPP   P+S     S   P   +LP+    ++ R  P P   P  P   
Sbjct: 527 PPSPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPE 586

Query: 427 APP--PPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPE 466
             P  PPP ++ +   F++SP     E      P+S  PPPE
Sbjct: 587 ESPMSPPPEASRLFPPFEESPLSPPPEE----SPLS--PPPE 622



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 101/344 (29%), Positives = 126/344 (36%), Gaps = 52/344 (15%)

Query: 127 PLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPP- 185
           PL PP   S    P SPP    R   P     + PP       PPP   + S P    P 
Sbjct: 670 PLSPPPEES----PTSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPL 725

Query: 186 -PVPSTPR--PIQSSPHNRGSPPVPG-GPRQPSPGPTP---PPFPGNRGTALGGGSIRQS 238
            P+P  P+  P    PH    P  P   PR   P  +P    P    +       ++ + 
Sbjct: 726 LPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEE 785

Query: 239 PLSSSSPFSNRPPLPPTPSRALDDKPPPPPP---PVGNRPSIHREAVPPP-----PPQNN 290
           P    SP +  P L P P   L   P    P   PV   P +     P P      PQ+ 
Sbjct: 786 P--HLSPQAEGPHLSPQPEE-LHLSPQTEEPHLSPVPEEPCLS----PQPEESHLSPQSE 838

Query: 291 KPPVPSTPRPSASSQAP---PPPPPPSRPGPPPLPPSSSGNDETPRLP---QRNLSLSSS 344
           +P +  +PRP  S  +P    PP  P    PP  P      +E P  P   + +LS    
Sbjct: 839 EPCL--SPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLG 896

Query: 345 TPPLPSPGRSGPLPPPPSERPPPPVRDP---PGRSGPLPPPPPVSRNGSTSRALPATPQL 401
            P L  PG   PL P P E P  P  +P   P    P P PPP+S    T+ A PA   L
Sbjct: 897 EPALSEPGEP-PLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPI-ITAAAPPALSPL 954

Query: 402 ---------PSRSGVDSPRSGP---RPPLPPDRPSAGAPPPPPP 433
                       S  +SP + P    P  PP   +   P P PP
Sbjct: 955 GELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPP 998



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 101/387 (26%), Positives = 134/387 (34%), Gaps = 65/387 (16%)

Query: 84   GGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSP 143
            G GGG  S     PP  G          ++   +  + G S P   PP          SP
Sbjct: 2262 GVGGGKASEPLLSPPPFG-------ESRKALEVKKEELGASSPSYGPPNLGFVD----SP 2310

Query: 144  PSGP--GRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNR 201
             SG   G   + +P     P  P+ +++ P  P +G +P   PP     P P       R
Sbjct: 2311 SSGTHLGGLELKTPDVFKAPLTPRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFR 2370

Query: 202  -GSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRAL 260
             GS   P    QP   P P P P     AL   S+       S PFS  P  P + S + 
Sbjct: 2371 PGSYTDPYA--QPPLTPRPQPPPPESCCALPPRSL------PSDPFSRVPASPQSQSSSQ 2422

Query: 261  DDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPS---RPG 317
                P P       PS        P P +  P  P +  P A    PP P PP    + G
Sbjct: 2423 SPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAG 2482

Query: 318  ------------PPPLPPSSSGNDETPRLPQRNLSLSSSTPP--LPSPGRSGPLPPP--- 360
                        P  LP   +G        + +  + S  PP  + SPG    +  P   
Sbjct: 2483 SLAHTSLGAGGFPAALPAGPAG--------ELHAKVPSGQPPNFVRSPGTGAFVGTPSPM 2534

Query: 361  ----------PSERPP---PPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS-- 405
                      PS +PP   P +  P G +    P P + +  ST+  +      PS S  
Sbjct: 2535 RFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFHPSGSPL 2594

Query: 406  GVDSPRSGPRPPLPPDRPSAGAPPPPP 432
            G  S  +G    L P RP +  PPP P
Sbjct: 2595 GPSSGSTGESYGLSPLRPPSVLPPPAP 2621



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 112/379 (29%), Positives = 135/379 (35%), Gaps = 54/379 (14%)

Query: 124 SRPPLLPPGGRSTSAKPFSPPSGPGRF-PVPSPGHRSGPPEP--------QRNRMPPPRP 174
           S PP   P        P SPP    R  P+P     S PPE         +    PPP  
Sbjct: 627 SPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEA 686

Query: 175 D-VGSKPDSIPPPVPSTPRPIQSSPHNR-GSPPVPGGPRQPSPGPTPPPFPGNRGTALGG 232
             +   P+  P   P    P    P +   S P+   P  P P   P   P + G  L  
Sbjct: 687 SRLSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLP-EEPQLCPRSEGPHL-- 743

Query: 233 GSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPP---PQN 289
                SP       S RP  P    +A +    P P      P +   AVP  P   PQ 
Sbjct: 744 -----SPRPEEPHLSPRPEEPHLSPQAEEPHLSPQP----EEPCLC--AVPEEPHLSPQA 792

Query: 290 NKP---PVPSTPRPSASSQAPPPPPPPSRP--GPPP----LPPSSSGNDETPRLPQRNLS 340
             P   P P     S  ++ P   P P  P   P P    L P S     +PR  + +LS
Sbjct: 793 EGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPRPEESHLS 852

Query: 341 LSSSTPPLPSPGRSGPLPPPPSERPPP---PVRDPPGRS--GPLPPPPPVSRNGSTSRA- 394
                PPL SP    P P  P + P P   P+  PPG     PL   P +S  G    + 
Sbjct: 853 PELEKPPL-SPRPEKP-PEEPGQCPAPEELPLFPPPGEPSLSPLLGEPALSEPGEPPLSP 910

Query: 395 LP-ATPQLPSRSGVDSPRSGPRPPLPPDRP---SAGAPPPPPPSTSIRNGF---QDSPCE 447
           LP   P  PS     SP+  P  PLPP      +A APP   P   +   F    DS  E
Sbjct: 911 LPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGELEYPFGAKGDSDPE 970

Query: 448 DEWESRFYFHPISDLPPPE 466
               +     PIS  PPPE
Sbjct: 971 SPLAAPILETPIS--PPPE 987



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 94/370 (25%), Positives = 119/370 (32%), Gaps = 80/370 (21%)

Query: 168  RMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRG 227
            R+PP    +GS P +  P +              GSP  P G    + G   PP      
Sbjct: 2105 RIPPQPGALGSPPPAAAPTIFI------------GSPTTPAGLSTSADGFLKPP------ 2146

Query: 228  TALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPP 287
                 GS+   P S    F   PP  P           P   P G  P+   E   P  P
Sbjct: 2147 ----AGSV-PGPDSPGELFLKLPPQVPA--------QVPSQDPFGLAPAYPLEPRFPTAP 2193

Query: 288  QNNKPPVPSTPRPSASSQAPPPPPPPSRPG---------PPPLPPSSSGNDETPRLPQRN 338
                P  P  P P+ +   PP     SRPG          PP  P    +   P L  R 
Sbjct: 2194 ----PTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFLKPRC 2249

Query: 339  LSLSSSTPPLPSPGRSGPLPPPPSERPPP---------PVRDPPGRSGPLPPPPPVSRNG 389
             SL +   P  SPG  G     P   PPP           ++  G S P   PP +    
Sbjct: 2250 PSLDNLAVP-ESPGVGGGKASEPLLSPPPFGESRKALEVKKEELGASSPSYGPPNLGFVD 2308

Query: 390  STSRA---------------LPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPS 434
            S S                  P TP+  S+    SP  G RP  PP    A AP PP   
Sbjct: 2309 SPSSGTHLGGLELKTPDVFKAPLTPR-ASQVEPQSPGLGLRPQEPPP-AQALAPSPPSHP 2366

Query: 435  TSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLARNE-SRSGSNRRER 493
               R G    P        +   P++  P P P        P  L  +  SR  ++ + +
Sbjct: 2367 DIFRPGSYTDP--------YAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQ 2418

Query: 494  GAPPLPPIPR 503
             +   P  PR
Sbjct: 2419 SSSQSPLTPR 2428



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 92/364 (25%), Positives = 118/364 (32%), Gaps = 85/364 (23%)

Query: 184  PPPVPSTPRPIQSSPHNRGSPPVPGGPR----QPSPGPTP------PPF--PGNRGTAL- 230
            P  + +TP  + + P     P + G  +    QP P P P      PP   PG +   + 
Sbjct: 4048 PLAIGTTPESMATEP-GEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQQQQVS 4106

Query: 231  -----GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPP-------PPPPVGNRPSIH 278
                 GGGS  Q    SSS  S+ P L   PS +L D+P         P  P+  RP  +
Sbjct: 4107 LLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQN 4166

Query: 279  REAVPPPPPQ------NNKPPVPSTP---------------------------------- 298
                 PP P          P V   P                                  
Sbjct: 4167 NTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALL 4226

Query: 299  --RPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGP 356
              R    SQA    PP   PG    P       +    PQ        T PL   G +GP
Sbjct: 4227 MQRQLQQSQAVRQTPPYQEPGTQTSPLQGLLGCQ----PQLGGFPGPQTGPLQELG-AGP 4281

Query: 357  LPPPPSERPPPPVRDPPGRS-GPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPR 415
             P  P   P PP     G   GP+ P PP S         P  P+ PS+    S +    
Sbjct: 4282 RPQGPPRLPAPPGALSTGPVLGPVHPTPPPSS--------PQEPKRPSQLPSPSSQLPTE 4333

Query: 416  PPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSY 475
              LPP  P  G P P  P+     G + SP   +     +   +    PP+   +T K  
Sbjct: 4334 AQLPPTHP--GTPKPQGPTLEPPPG-RVSPAAAQLADTLFSKGLGPWDPPDNLAETQKPE 4390

Query: 476  PSKL 479
             S L
Sbjct: 4391 QSSL 4394



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 70/282 (24%), Positives = 93/282 (32%), Gaps = 41/282 (14%)

Query: 125  RPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIP 184
            +PPL  PG +           G     + S         P  + +  P   +G +P S+ 
Sbjct: 4092 QPPLRLPGQQQQQVSLLHTAGGGSHGQLGSGSSSEASSVP--HLLAQPSVSLGDQPGSMT 4149

Query: 185  -----PPVPSTPRPIQSSPHNRGSPPVPGGP----RQPSPGPTPPPFPGNRGTALGGGSI 235
                 P  P   RP+Q+   N G  P   GP     Q  PG    P  G     L G   
Sbjct: 4150 QNLLGPQQPMLERPMQN---NTGPQPPKPGPVLQSGQGLPGVGIMPTVGQLRAQLQGVLA 4206

Query: 236  RQSPLSSSSPFSNRP------PLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQN 289
            +   L   SP   +             S+A+   PP   P     P    + +    PQ 
Sbjct: 4207 KNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTSPL---QGLLGCQPQL 4263

Query: 290  NKPPVPSTPRPSASSQAPPPPPPPSRPGPP-------------PLPPSSSGNDETPRLPQ 336
               P P T         P P  PP  P PP             P PP SS     P+ P+
Sbjct: 4264 GGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSS-----PQEPK 4318

Query: 337  RNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGP 378
            R   L S +  LP+  +  P  P   +   P +  PPGR  P
Sbjct: 4319 RPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPPGRVSP 4360



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 53/179 (29%), Positives = 66/179 (36%), Gaps = 35/179 (19%)

Query: 180  PDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPG--NRGTALGGGSIRQ 237
            P+S     P +P    + P  +G    PGG  +   G +P   P    +  A+  G   +
Sbjct: 4812 PNSYEVLFPESPARAGTEP-KKGEAEGPGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLK 4870

Query: 238  SPLSSSSPFSNRPPLPPTPS-------------RALDDKPP--PPPPPVGNRPSIHREAV 282
            S L   S      P P  P+             R L   PP  P PPP    PS    A 
Sbjct: 4871 SQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPS---PAS 4927

Query: 283  PPPPPQNN-------KPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL 334
            PP  P          +PPVPS P P ASS      P  +RP P   PP    +   PRL
Sbjct: 4928 PPTEPLVELPTEPLAEPPVPS-PLPLASS------PESARPKPRARPPEEGEDSRPPRL 4979



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 33/109 (30%), Positives = 39/109 (35%), Gaps = 11/109 (10%)

Query: 276  SIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
            S+ ++  P P P        +         + PPP  PS P P PL PS       P  P
Sbjct: 4877 SLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPP-PSPLAPS-------PASP 4928

Query: 336  QRNLSLSSSTPPLPSPGRSGPLP---PPPSERPPPPVRDPPGRSGPLPP 381
                 +   T PL  P    PLP    P S RP P  R P       PP
Sbjct: 4929 PTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRPP 4977



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 69/296 (23%), Positives = 92/296 (31%), Gaps = 46/296 (15%)

Query: 97   PPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPG 156
            PP L  L +   P   +  + D +S  + P L  P      A    P   P     PSPG
Sbjct: 948  PPALSPLGELEYP-FGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPG 1006

Query: 157  HRSGPPEP--------------QRNRMPPPRPDVGSKPDSIPPPVPSTPRPI-------- 194
               GP  P              Q + +P   P     P ++P  VPS   PI        
Sbjct: 1007 SPVGPASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSD 1066

Query: 195  QSSPHNRGS--------PPVPGGPRQPSPGP-----TPPPFPGNRGTALGGGSIRQSPLS 241
            ++  H   +        P +      P P P      P P P        G     +PL 
Sbjct: 1067 EAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAPSPAPALDDFSGLGEDTAPLD 1126

Query: 242  SSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPS 301
                  ++P    TP     +         G+   +  E + P  P    P    T    
Sbjct: 1127 GIDAPGSQPEPGQTPGSLASELK-------GSPVLLDPEELAPVTPMEVYPECKQTAGQG 1179

Query: 302  ASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLS--SSTPPLPSPGRSG 355
            +  +    P  P  P PP L  S   N E   L Q + S S   S P L SP   G
Sbjct: 1180 SPCEEQEEPRAPVAPTPPTLIKSDIVN-EISNLSQGDASASFPGSEPLLGSPDPEG 1234



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 95/343 (27%), Positives = 117/343 (34%), Gaps = 87/343 (25%)

Query: 160  GPPEPQRNRMPPPRP------DVGSKPDSIPPPVPSTPRPIQS---SPHNRGS--PPVPG 208
            G P  + +R P  RP       +G+ P S   P+ S P   QS       RG    P PG
Sbjct: 1910 GTPGLEGSRTPLQRPFLQGGLPLGNLPSS--SPMDSYPGLCQSPFLDSRERGGFFSPEPG 1967

Query: 209  GPRQPSPG-----PTPPPFPGNRGTALGGGSIRQS-----------PLSSSSP------- 245
             P  P  G     P+ P  P   G   G    ++S            LS+ SP       
Sbjct: 1968 EPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANIN 2027

Query: 246  FSN-RPPLPPTPSRALD-----------DKPPPPPPPVGNRPSIHR--EAVPPPPPQNNK 291
            F N +   P   SR              DK P       NR + HR  +       Q NK
Sbjct: 2028 FPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAA-HRINKVQKQAESQINK 2086

Query: 292  PP-----VPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSS-- 344
                      T RP+   + PP P     P P   P    G+  TP      LS S+   
Sbjct: 2087 QTKVGDIARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTP----AGLSTSADGF 2142

Query: 345  -TPPLPS-PGRSGP----LPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPAT 398
              PP  S PG   P    L  PP      P +DP G    L P  P+     T  A P  
Sbjct: 2143 LKPPAGSVPGPDSPGELFLKLPPQVPAQVPSQDPFG----LAPAYPLEPRFPT--APPTY 2196

Query: 399  PQLPSRSGVDSPRSGPRPPL--PPDRPSAGAP------PPPPP 433
            P  PS +G  +     +PP+     RP AG P      PP  P
Sbjct: 2197 PPYPSPTGAPA-----QPPMLGASSRPGAGQPGEFHTTPPGTP 2234



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 30/101 (29%), Positives = 38/101 (37%), Gaps = 8/101 (7%)

Query: 318  PPPLPPSS-SGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRS 376
            P P PP+  S       L  R LS      P P P    P P  P   P   +   P   
Sbjct: 4884 PAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAE 4943

Query: 377  GPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPP 417
             P+P P P++ +  ++R  P     P   G DS     RPP
Sbjct: 4944 PPVPSPLPLASSPESARPKPRA--RPPEEGEDS-----RPP 4977



 Score = 34.7 bits (78), Expect = 0.21
 Identities = 80/343 (23%), Positives = 110/343 (32%), Gaps = 82/343 (23%)

Query: 85   GGGGGGSFG-----GGGPPGLGGLFQAGMPKLR----------------STANRDNDSGG 123
            G G G S       G   PG+ GL Q  + K R                +T  ++ ++  
Sbjct: 2649 GTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAA 2708

Query: 124  SRPPLLPPGGRSTSAKPFSPPS---GPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180
            +    + P G S  A+P SP       G+ P      +S       +++  P    GS P
Sbjct: 2709 AAAGAVGPPG-SWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFP 2767

Query: 181  D----SIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTP----------------- 219
                 S PPP P+TP  +  +             R P PG  P                 
Sbjct: 2768 SDDRLSRPPP-PATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQLWQQQQATAA 2826

Query: 220  --------PPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPV 271
                      FP   G  LG    RQ+  S  +  S R P P  P       P  P   +
Sbjct: 2827 TSMRFAMSARFPSTPGPELG----RQALGSPLAGISTRLPGPGEPVPG----PAGPAQFI 2878

Query: 272  GNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP------------PSRPGPP 319
              R ++ +   P   P   + P P  PR    S+ P    P            P +P  P
Sbjct: 2879 ELRHNVQKGLGPGGTPFPGQGP-PQRPRFYPVSEDPHRLAPEGLRGLAVSGLPPQKPSAP 2937

Query: 320  PLPPSSSGNDETPR-----LPQRNLSLSSSTPPLPSPGRSGPL 357
            P P  ++    TP      LP   L L +  P     GR  PL
Sbjct: 2938 PAPELNNSLHPTPHTKGPTLP-TGLELVNRPPSSTELGRPNPL 2979



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 51/191 (26%), Positives = 64/191 (33%), Gaps = 58/191 (30%)

Query: 149  RFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQ--SSPHNRGSPPV 206
            RFP  +PG     PE  R  +  P   + ++      PVP    P Q     HN      
Sbjct: 2836 RFP-STPG-----PELGRQALGSPLAGISTRLPGPGEPVPGPAGPAQFIELRHNVQKGLG 2889

Query: 207  PGGPRQPSPGPTPPP--FP-----------GNRGTALGGGSIRQSPLSSSSPFSNRPPLP 253
            PGG   P  GP   P  +P           G RG A+ G                   LP
Sbjct: 2890 PGGTPFPGQGPPQRPRFYPVSEDPHRLAPEGLRGLAVSG-------------------LP 2930

Query: 254  PTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPS----TPRPSASSQAPPP 309
            P        KP  PP P  N  S+H      P P    P +P+      RP +S++   P
Sbjct: 2931 P-------QKPSAPPAPELNN-SLH------PTPHTKGPTLPTGLELVNRPPSSTELGRP 2976

Query: 310  PPPPSRPGPPP 320
             P     G  P
Sbjct: 2977 NPLALEAGKLP 2987



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 38/159 (23%), Positives = 51/159 (32%), Gaps = 43/159 (27%)

Query: 131  PGGRSTSAKPFSPPSGPG---RFPVPSPGHRSGPP----EPQRNRMPPPRP--------- 174
            PGG+    +  SP +GP    +F    PG+            +   P P P         
Sbjct: 4838 PGGKEKGLEGKSPDTGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYN 4897

Query: 175  -------DVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRG 227
                    + + P   P P PS   P  +SP       +P  P    P P+P P      
Sbjct: 4898 VSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPL----- 4952

Query: 228  TALGGGSIRQSPLSSSSPFSNRP-PLPPTPSRALDDKPP 265
                          +SSP S RP P    P    D +PP
Sbjct: 4953 --------------ASSPESARPKPRARPPEEGEDSRPP 4977



 Score = 33.9 bits (76), Expect = 0.35
 Identities = 48/197 (24%), Positives = 61/197 (30%), Gaps = 23/197 (11%)

Query: 220  PPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHR 279
            P F      A G G   +  L +S    + P +    SR L+ K   P P  G       
Sbjct: 1797 PSFGLGTPKAKGDGGSERKELPTSQKGDDGPDIADEESRGLEGKADTPGPEDGG------ 1850

Query: 280  EAVPPPPPQNNKPPVPSTPRPSASSQ--APPPPPPPSRPGPPPLPPSSSGNDETPRLPQR 337
                P P    KP  P     S+     +    P         L     G++    L   
Sbjct: 1851 VKASPVPSDPEKPGTPGEGMLSSDLDRISTEELPKMESKDLQQLFKDVLGSEREQHLGCG 1910

Query: 338  NLSLSSSTPPLPSPGRSG--PLPPPPSERP--------PPPVRDPPGRSGPLPPPP---- 383
               L  S  PL  P   G  PL   PS  P          P  D   R G   P P    
Sbjct: 1911 TPGLEGSRTPLQRPFLQGGLPLGNLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPD 1970

Query: 384  -PVSRNGSTSRALPATP 399
             P + +G T+ + P TP
Sbjct: 1971 SPWTGSGGTTPSTPTTP 1987


>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
          Length = 2161

 Score =  114 bits (284), Expect = 3e-25
 Identities = 143/513 (27%), Positives = 183/513 (35%), Gaps = 126/513 (24%)

Query: 2    PVPPPPAPPPPPT------------------FALANTEKPTLNKT--------------E 29
            PVPP P+P P P                      A  E    N+               E
Sbjct: 1206 PVPPSPSPVPTPASPSGPATLDFTSQFGAALVGAARREGGWQNEARRRSTLFLSTDAGDE 1265

Query: 30   QAGRNALLSDISKGKKLKKTVTNDR---SAPILDKPKGAGAGGGGGGFGGGG-GFGGGGG 85
              G   L +  + G +L+ + + D    SA    + + AG+G G GG+G G   +GGGGG
Sbjct: 1266 DGGDGGLGTGAAPGPRLRHSKSIDEGMFSAEPYLRLESAGSGAGYGGYGAGSRAYGGGGG 1325

Query: 86   GGGGGSFGGGGP---PGLGGLFQAGMP-----KLRSTANRDNDSGGSRPPLLPPGGRSTS 137
                 SF    P   P  G       P       R  A +++  GG  P           
Sbjct: 1326 SSAFTSFLPPRPLVHPLTGKALDPASPLGLALAARERALKESSEGGGAPQ---------- 1375

Query: 138  AKPFSPPSGPGRFPVPSPGHRS--------------GPPEPQRNRMPPPRPDVGSKPDSI 183
              P  PPS     P P+P H S               PP+P R  +   R  +GS+  S+
Sbjct: 1376 -PPPRPPSPRYEAPPPTPHHHSPHAHHEPVLRLWGASPPDPARRELGY-RAGLGSQEKSL 1433

Query: 184  PPPVPSTPRPIQSSPHNRGSPPVPG-GPRQPSPGPTPP-PFPGNRGTALGGGSIRQSPLS 241
            P   P+  R +     +R  P  PG GP     G  PP P PG              P  
Sbjct: 1434 PASPPAARRSLL----HRLPPTAPGVGPLLLQLGTEPPAPHPGV-----------SKPWR 1478

Query: 242  SSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRP-SIHREAVPPPPPQNNKPPVPSTPRP 300
            S++P    P   P   R L++  P  P   G  P S     VPPP P+ + PP P++PR 
Sbjct: 1479 SAAP--EEPERLPLHVRFLENCQPRAPVTSGRGPPSEDGPGVPPPSPRRSVPPSPTSPRA 1536

Query: 301  SASSQAPP---PPPPPS-----------RPGPPPLPPSSSGNDETPRLPQRNLSLSSSTP 346
            S  +  P    PPP PS            P PPPL  S+S   E P  P           
Sbjct: 1537 SEENGLPLLVLPPPAPSVDVEDGEFLFVEPLPPPLEFSNSF--EKPESPL---------- 1584

Query: 347  PLPSPGRSGPLPPPPSERPP-PPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRS 405
               +PG   PLP  P+   P PPV  PP      PP    + +  TS            S
Sbjct: 1585 ---TPGPPHPLPDTPAPATPLPPV--PPPAVAAAPPTLDSTASSLTSYDSEVATLTQGAS 1639

Query: 406  GVDSPRSGPRPPLPPDRPSAGAP---PPPPPST 435
                    P PP P   P+  AP   P PPP T
Sbjct: 1640 AAPGDPHPPGPPAPA-APAPAAPQPGPDPPPGT 1671



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 115/424 (27%), Positives = 144/424 (33%), Gaps = 117/424 (27%)

Query: 85   GGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPP 144
            G GG  S G   P G      +  P  R+  + +      RP  LPPG            
Sbjct: 840  GPGGLASLGKHRPKGFFATESSFDPHHRAQPSYE------RPSFLPPG------------ 881

Query: 145  SGPGRFPVPSPGHRSGPPEPQRNRMPPPRP------DVGSKPDSIPPPVPSTPRPIQSSP 198
              PG   +       G  E  R  + PP         V    D  PPP  S P P  S+P
Sbjct: 882  --PG---LMLRQKSIGAAEDDRPYLAPPAMKFSRSLSVPGSEDIPPPPTTSPPEPPYSTP 936

Query: 199  HNRGSPPVPGGPRQPSPGPTPPPF-PGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPS 257
                  PVP    + +P P   PF PG+ G           PL +SSP S   P PP   
Sbjct: 937  ------PVPSSSGRLTPSPRGGPFNPGSGG-----------PLPASSPASFDGPSPPDTR 979

Query: 258  RALDDKP----PPPPPPVGNRPSIHREAVPPPPPQNNK--PPVPSTPRPSASSQAPPP-- 309
                +K      P PP   + P  H    PPP P ++   PP P       S   PPP  
Sbjct: 980  VGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRL 1039

Query: 310  ---PPPPSR------PGPPPLPPSSS---------GNDETP-----RLPQRNLSLSSSTP 346
               P P  R      P P P  PS S         G+ + P     +LP R  S +   P
Sbjct: 1040 ALGPQPSLRGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVP 1099

Query: 347  PLPSPGRSGPL----------------PPPPSERPPPPVRDPPGRSGP-----LPPPPPV 385
                 GR GPL                PP PS   P   + PP  + P     +P P  +
Sbjct: 1100 ARSGRGRKGPLVKQTKVEGEPQKGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTII 1159

Query: 386  -----------SRNGSTSRALPATPQLPSRSG-------VDSPRSGPRPPLPPDRPSAGA 427
                       S  GS++ A P T   P+  G         +P   P PP P   P+  +
Sbjct: 1160 IKAPSTSSSGRSSQGSSTEAEPPTQPEPTGGGGGGGSSPSPAPAMSPVPPSPSPVPTPAS 1219

Query: 428  PPPP 431
            P  P
Sbjct: 1220 PSGP 1223



 Score = 79.7 bits (195), Expect = 6e-15
 Identities = 131/494 (26%), Positives = 154/494 (31%), Gaps = 124/494 (25%)

Query: 2    PVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDK 61
            P  P P P PPP      T+        ++  +  L  IS    L               
Sbjct: 1658 PAAPQPGPDPPP-----GTDSGIEEVDSRSSSDHPLETISSASTLSSL------------ 1700

Query: 62   PKGAGAGGGGGGFGGGGGFGGGGGGG-----------GGGSFGGGGPPGLGGLFQAGMP- 109
                 +  GGG  GGGGG G G   G            G +FGG   PG     Q   P 
Sbjct: 1701 -----SAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPS 1755

Query: 110  KLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRM 169
            KLR  A     SGG RP   P GG      P SP        V   G  +      R   
Sbjct: 1756 KLRGRAL--GASGGLRPG--PSGGLRDPVTPTSP-------TVSVTGAGTDGLLALRACS 1804

Query: 170  PPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSP--PVPGGPRQPSPGPTPPP------ 221
             PP   V   P ++ P VP  P P  SS   +  P    PG P  P PGP   P      
Sbjct: 1805 GPPTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPPLPGPLAQPQASALA 1864

Query: 222  --------------------------FPGNRGTALGGG---------------SIRQSPL 240
                                       P  RG + GGG               S+++  L
Sbjct: 1865 TVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRL 1924

Query: 241  SSSSPFSNRPPLPPTPSRALDD---KPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPST 297
            S  S  S    L   P  +L     KPP PP P G   S    A P     +      ST
Sbjct: 1925 SDDSQSS----LLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTST 1980

Query: 298  PRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPL 357
                       PP     P P  LP S       PR         SS P LP    SGPL
Sbjct: 1981 RHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPR--------PSSLPILP----SGPL 2028

Query: 358  PPPPSERPPPPVRDPPGRSGPLPP---PPPVSRNGSTSRALPATPQLPSRSGVDSPRSGP 414
             P   +    P     G + P  P   PP    +G    AL    +  S + + S     
Sbjct: 2029 YPGLFDIRGSPTGGAGGSADPFAPVFVPPHPGISGGLGGALSGASRSLSPTRLLS----- 2083

Query: 415  RPPLPPDRPSAGAP 428
               LPPD+P    P
Sbjct: 2084 ---LPPDKPFGAKP 2094



 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 116/449 (25%), Positives = 146/449 (32%), Gaps = 53/449 (11%)

Query: 4    PPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPK 63
            P  P PP PP  A      P        G ++ + ++         +    SA  L    
Sbjct: 1642 PGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDHPLETISSASTLSSLS 1701

Query: 64   GAGAGGGGGGFGGGGGFGGGG-------GGGGGGSFGGGGPPGLGGLFQAGMP-KLRSTA 115
              G G  GGG G G G   G            G +FGG   PG     Q   P KLR  A
Sbjct: 1702 AEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPPYPPQLMTPSKLRGRA 1761

Query: 116  NRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPD 175
                 SGG RP   P GG      P SP        V   G  +      R    PP   
Sbjct: 1762 L--GASGGLRPG--PSGGLRDPVTPTSPT-------VSVTGAGTDGLLALRACSGPPTAG 1810

Query: 176  VGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGN---------- 225
            V   P ++ P VP  P P  SS   +  P   G      PGP PPP PG           
Sbjct: 1811 VAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEG------PGPPPPPLPGPLAQPQASALA 1864

Query: 226  --RGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPS-IHREAV 282
              + + +   S +      SS      P     S    D        V  R S + R+ +
Sbjct: 1865 TVKASIISELSSKLQQFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRL 1924

Query: 283  PPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLS 342
                  +++  + S P  S     P PP PP   G    P +++    T   P  +   S
Sbjct: 1925 S----DDSQSSLLSKPVSSLFQNWPKPPLPPLPTGTGVSPTAAAAPGATS--PSAS---S 1975

Query: 343  SSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLP 402
            SST      G    + PP   R P P   P       P P P     S+   LP+ P  P
Sbjct: 1976 SSTSTRHLQGVEFEMRPPLLRRAPSPSLLPASEHKVSPAPRP-----SSLPILPSGPLYP 2030

Query: 403  SRSGV-DSPRSGPRPPLPPDRPSAGAPPP 430
                +  SP  G      P  P    P P
Sbjct: 2031 GLFDIRGSPTGGAGGSADPFAPVFVPPHP 2059



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 83/320 (25%), Positives = 107/320 (33%), Gaps = 84/320 (26%)

Query: 157  HRSGPPEPQRNRMPPPRPDVGSKP----------DSIPPPVPSTP--RPIQSSPHNRGSP 204
            H+  P   Q  R+PPP   + SK           +  P PVPS    R +     N+   
Sbjct: 767  HKKAPQ--QAKRLPPPTISLRSKSMTSELEEMEYEQQPAPVPSMEKKRTVYQMALNKLDE 824

Query: 205  PVPGGPRQPSPGPTPPP-----FPGNRGTALGGGSIRQSPLSSSSPFSNRPP-LPPTPSR 258
             +    +  S   +P P        +R            P   + P   RP  LPP P  
Sbjct: 825  ILAAAQQTISASESPGPGGLASLGKHRPKGFFATESSFDPHHRAQPSYERPSFLPPGPGL 884

Query: 259  ALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGP 318
             L  K       +G          PP    +    VP        S+  PPPP  S P P
Sbjct: 885  MLRQKS------IGAAEDDRPYLAPPAMKFSRSLSVPG-------SEDIPPPPTTSPPEP 931

Query: 319  PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGP 378
            P                        STPP+PS   SG L P P   P       PG  GP
Sbjct: 932  P-----------------------YSTPPVPSS--SGRLTPSPRGGP-----FNPGSGGP 961

Query: 379  LP---------PPPPVSRNGSTSRAL-------PATPQLPSRSGVDSPRSGPR-----PP 417
            LP         P PP +R GS  ++L       PA    P      +P   P      PP
Sbjct: 962  LPASSPASFDGPSPPDTRVGSREKSLYHSGPLPPAHHHPPHHHHHHAPPPQPHHHHAHPP 1021

Query: 418  LPPDRPSAGAPPPPPPSTSI 437
             PP+  + G+P  PPP  ++
Sbjct: 1022 HPPEMETGGSPDDPPPRLAL 1041



 Score = 55.8 bits (133), Expect = 9e-08
 Identities = 69/285 (24%), Positives = 86/285 (30%), Gaps = 86/285 (30%)

Query: 95   GGP--PGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPV 152
            GGP  PG GG   A  P     A+ D    G  PP    G R  S     P       P 
Sbjct: 951  GGPFNPGSGGPLPASSP-----ASFD----GPSPPDTRVGSREKSLYHSGPLPPAHHHPP 1001

Query: 153  PSPGHRSGPPEPQRNRMPPPRP---DVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGG 209
                H + PP+P  +   PP P   + G  PD  PP +   P+P        G  P PG 
Sbjct: 1002 HHHHHHAPPPQPHHHHAHPPHPPEMETGGSPDDPPPRLALGPQPSLRGWRGGGPSPTPGA 1061

Query: 210  PRQPSPGPTPPPFPGNRGTALG------------------GGSIRQSPLSSSSPFSNRPP 251
            P     G        ++G AL                    G  R+ PL   +     P 
Sbjct: 1062 PSPSHHGSAGGGGGSSQGPALRYFQLPPRAASAAMYVPARSGRGRKGPLVKQTKVEGEPQ 1121

Query: 252  ----LPPTPSRALDDKPPPPP--------------------------------------P 269
                LPP PS      P PPP                                      P
Sbjct: 1122 KGGGLPPAPSPTSPASPQPPPAVAAPSEKNSIPIPTIIIKAPSTSSSGRSSQGSSTEAEP 1181

Query: 270  PV-----------GNRPSIHREAVPPPPPQNNKPPVPSTPRPSAS 303
            P            G+ PS    A+ P PP  +  P P++P   A+
Sbjct: 1182 PTQPEPTGGGGGGGSSPS-PAPAMSPVPPSPSPVPTPASPSGPAT 1225



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 89/354 (25%), Positives = 112/354 (31%), Gaps = 77/354 (21%)

Query: 94   GGGPPGLGGLFQAGMPKLRS-----TANRDNDSGGSRPPLLPPGGRSTSAK--------P 140
            G GPP   G         RS     T+ R ++  G    +LPP   S   +        P
Sbjct: 1507 GRGPPSEDGPGVPPPSPRRSVPPSPTSPRASEENGLPLLVLPPPAPSVDVEDGEFLFVEP 1566

Query: 141  FSPP-SGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSI---PPPVPSTPRPIQS 196
              PP      F  P      GPP P  +   P  P     P ++   PP + ST   + S
Sbjct: 1567 LPPPLEFSNSFEKPESPLTPGPPHPLPDTPAPATPLPPVPPPAVAAAPPTLDSTASSLTS 1626

Query: 197  -----------------SPHNRGSP-PVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQS 238
                              PH  G P P    P  P PGP PPP   +    +   S    
Sbjct: 1627 YDSEVATLTQGASAAPGDPHPPGPPAPAAPAPAAPQPGPDPPPGTDSGIEEVDSRSSSDH 1686

Query: 239  PL---SSSSPFSNR---------------------PPLPPTPSRALDDK-------PPPP 267
            PL   SS+S  S+                      P L  T    LD +       P PP
Sbjct: 1687 PLETISSASTLSSLSAEGGGSAGGGGGAGAGVASGPELLDTYVAYLDGQAFGGSSTPGPP 1746

Query: 268  PPPVGNRPSIHREAV--------PPPPPQNNKPPVPSTPRPSASSQAPPPPPP-PSRPGP 318
             PP    PS  R           P P      P  P++P  S +           +  GP
Sbjct: 1747 YPPQLMTPSKLRGRALGASGGLRPGPSGGLRDPVTPTSPTVSVTGAGTDGLLALRACSGP 1806

Query: 319  PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDP 372
            P    +       P +P   L  +SS P    P   GP PPPP    P P+  P
Sbjct: 1807 PTAGVAGGPVAVEPEVPPVPLPTASSLPRKLLPWEEGPGPPPPP--LPGPLAQP 1858



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 66/214 (30%), Positives = 80/214 (37%), Gaps = 43/214 (20%)

Query: 63   KGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANR--DND 120
            +G   GG     G       G  GGGGGS  G   P L   FQ   P+  S A       
Sbjct: 1048 RGWRGGGPSPTPGAPSPSHHGSAGGGGGSSQG---PALR-YFQLP-PRAASAAMYVPARS 1102

Query: 121  SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKP 180
              G + PL+    + T  +   P  G G  P PSP   + P  PQ    PPP     S+ 
Sbjct: 1103 GRGRKGPLV----KQTKVEG-EPQKGGGLPPAPSP---TSPASPQ----PPPAVAAPSEK 1150

Query: 181  DSIPPP--VPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQS 238
            +SIP P  +   P    S   ++GS      P QP P           G   GGGS    
Sbjct: 1151 NSIPIPTIIIKAPSTSSSGRSSQGSSTEAEPPTQPEP----------TGGGGGGGS---- 1196

Query: 239  PLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVG 272
               S SP     P+PP+PS       P P  P G
Sbjct: 1197 ---SPSPAPAMSPVPPSPSPV-----PTPASPSG 1222



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 73/275 (26%), Positives = 92/275 (33%), Gaps = 43/275 (15%)

Query: 1    MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILD 60
            +P    P PPPPP        + +   T +A   +++S++S                 L 
Sbjct: 1838 LPWEEGPGPPPPPLPGPLAQPQASALATVKA---SIISELSSK---------------LQ 1879

Query: 61   KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGL--GGLFQAGMPKLRSTANRD 118
            +  G+ A GG   +  GG  GGG    GG S+       L    L       L S     
Sbjct: 1880 QFGGSSAAGGALPWARGGSGGGGDSHHGGASYVPERTSSLQRQRLSDDSQSSLLSKPVSS 1939

Query: 119  NDSGGSRPPLLP-PGGRSTSAKPFSPP---SGPGRFPVPSPGHRSGPP----EPQRNRMP 170
                  +PPL P P G   S    + P   S        S  H  G       P   R P
Sbjct: 1940 LFQNWPKPPLPPLPTGTGVSPTAAAAPGATSPSASSSSTSTRHLQGVEFEMRPPLLRRAP 1999

Query: 171  PPRPDVGSKPDSIPPPVPSTPRPIQSSP------HNRGSPP-VPGGPRQPSPGPTPPPFP 223
             P     S+    P P PS+   + S P        RGSP    GG   P      PP P
Sbjct: 2000 SPSLLPASEHKVSPAPRPSSLPILPSGPLYPGLFDIRGSPTGGAGGSADPFAPVFVPPHP 2059

Query: 224  ---GNRGTALGGGSIRQSP-----LSSSSPFSNRP 250
               G  G AL G S   SP     L    PF  +P
Sbjct: 2060 GISGGLGGALSGASRSLSPTRLLSLPPDKPFGAKP 2094



 Score = 30.8 bits (68), Expect = 3.0
 Identities = 21/84 (25%), Positives = 32/84 (38%), Gaps = 1/84 (1%)

Query: 11  PPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGAGGG 70
           P PT       +P+   T+ +      +   +G + +             +P+G  +  G
Sbjct: 462 PGPTSGSQGQSQPSAPTTKLSSGTLRSASSPRGARARSPSRGRHPEDAKRQPRGRPSSSG 521

Query: 71  GGGFGGGGGFGGGGGGGGG-GSFG 93
               G  GG GG GG GG  GS G
Sbjct: 522 TPREGPAGGTGGSGGPGGSLGSRG 545



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 26/76 (34%), Positives = 32/76 (42%), Gaps = 17/76 (22%)

Query: 370 RDPPGRSGPLPPPPPVSRNGSTSRALP-----ATPQLPSRSGVDSPRSGPRPPLPPDRPS 424
           R PPG +G   PP  +  N  TS ALP     + P   S SG   P SG          S
Sbjct: 421 RGPPG-TGLTVPPALLRANSDTSMALPDWMVFSAPGAAS-SGAPGPTSG----------S 468

Query: 425 AGAPPPPPPSTSIRNG 440
            G   P  P+T + +G
Sbjct: 469 QGQSQPSAPTTKLSSG 484


>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
           sapiens]
          Length = 2715

 Score =  111 bits (278), Expect = 1e-24
 Identities = 114/378 (30%), Positives = 142/378 (37%), Gaps = 85/378 (22%)

Query: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPV--PSPGHRSGPPEPQRNRMPPPRPDVGSKPDSI 183
           PPL PP    +   P  PPS     P+  P P   S PP P     PPP P    + +S 
Sbjct: 404 PPLTPPA--PSPPPPLPPPSTSPPPPLCPPPPPPVSPPPLPS----PPPPPAQEEQEESP 457

Query: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGPR------QPSPGPTPPPFPGNRGTALGG----- 232
           PP VP+T          RG PP+    R      +  P  T PP P    TA GG     
Sbjct: 458 PPVVPAT------CSRKRGRPPLTPSQRAEREAARAGPEGTSPPTP-TPSTATGGPPEDS 510

Query: 233 -----------GSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPP---------PPVG 272
                       +IRQ  +   S  S+R  +  TP R +D+ PP PP         PP+ 
Sbjct: 511 PTVAPKSTTFLKNIRQFIMPVVSARSSR--VIKTPRRFMDEDPPKPPKVEVSPVLRPPIT 568

Query: 273 NRPSIHREAVPPPPPQNNKPPVPSTPRP-----------------SASSQAPPP---PPP 312
             P + +E  P P P    P  PSTP P                 S + + PPP   PPP
Sbjct: 569 TSPPVPQEPAPVPSPP-RAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPP 627

Query: 313 PSRPGPPPLPPSSSGNDETPRLPQ-----RNLSLSSST---PPLPSPGRSGPLPPPPSER 364
           P  P PPP P +SS      R PQ      +L +  S    PPL +P    P PPP  + 
Sbjct: 628 PPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDS 687

Query: 365 PPPPVRDPPGRSGPLPPP---PPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPD 421
           P  P     GR+  L  P   P V+       +    P L +     +    P   L   
Sbjct: 688 PAEPEPRAVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQ 747

Query: 422 RPSAGAPPP-----PPPS 434
                 PPP     PPPS
Sbjct: 748 LLPQALPPPQPQLQPPPS 765



 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 130/519 (25%), Positives = 169/519 (32%), Gaps = 134/519 (25%)

Query: 4    PPPPAPPPPPTFALANTEKPTLNKTEQ-AGRNALLSDISKGKKLKKTVTNDRSAPILDKP 62
            PP PAP PPP   L     P     E  +G +A  +D+     L  T       P  ++ 
Sbjct: 1960 PPGPAPSPPPPEDLG----PDFEDMEVVSGLSA--ADLDFAASLLGT------EPFQEEI 2007

Query: 63   KGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGP--------------PGLGGLFQAGM 108
              AGA             G   GG G  S     P              PGL      G 
Sbjct: 2008 VAAGA------------MGSSHGGPGDSSEEESSPTSRYIHFPVTVVSAPGLAPSATPGA 2055

Query: 109  PKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNR 168
            P++      D+ +      +  P G+ T      PPSGPG         R+G        
Sbjct: 2056 PRIEQLDGVDDGTDSEAEAVQQPRGQGT------PPSGPGVV-------RAGV------- 2095

Query: 169  MPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPG-GPRQPSPGPTPPPFPGNRG 227
                   +G+  D   PP       +     N G P   G GPR+ S  P PP   G++ 
Sbjct: 2096 -------LGAAGDRARPPEDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQP 2148

Query: 228  TALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHR-------- 279
            +      +  SP   +  F+  P  P     +L   P PP P       +++        
Sbjct: 2149 SQ----GLTASPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKM 2204

Query: 280  --EAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP---------PSRPGPPPLPPSSSGN 328
              E  P PPP   +PP+P T  P+A +    PP P           RP PPP PP     
Sbjct: 2205 AGEGEPVPPPVK-QPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPP----- 2258

Query: 329  DETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPP---PPV 385
                              PL     SGP  PP        V    GRS P PPP   P +
Sbjct: 2259 ------------------PLTLVLSSGPASPPRQAIRVKRVSTFSGRSPPAPPPYKAPRL 2300

Query: 386  SRNGSTSRALPATPQL------------PSRSGV---DSP--RSGPRPPLPPDRPSAGAP 428
              +G  S   P  P L            P+  GV   D P   +G   P P    S   P
Sbjct: 2301 DEDGEASEDTPQVPGLGSGGFSRVRMKTPTVRGVLDLDRPGEPAGEESPGPLQERSPLLP 2360

Query: 429  PPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEP 467
             P      + +G  D   E +W         S+  PP P
Sbjct: 2361 LPEDGPPQVPDGPPDLLLESQWHHYSGEASSSEEEPPSP 2399



 Score = 83.2 bits (204), Expect = 5e-16
 Identities = 76/272 (27%), Positives = 94/272 (34%), Gaps = 60/272 (22%)

Query: 252 LPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPP 311
           LPP P       PPPP PP    P       PPPPP  + PP+PS P P A  +    PP
Sbjct: 401 LPPPPLTPPAPSPPPPLPPPSTSPP--PPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPP 458

Query: 312 P------PSRPGPPPLPPSSSGNDETPRL-------PQRNLSLSSSTPPLPSP------- 351
           P        + G PPL PS     E  R        P    S ++  PP  SP       
Sbjct: 459 PVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKST 518

Query: 352 ---------------GRSGPL------------PPPPSERPPPPVRDP-------PGRSG 377
                           RS  +            P PP     P +R P       P    
Sbjct: 519 TFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITTSPPVPQEPA 578

Query: 378 PLPPPPPVSRNGSTSRALP----ATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPP 433
           P+P PP      ST   LP    +  + P+       R  P PP  P  P A +PPP P 
Sbjct: 579 PVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPPPAPA 638

Query: 434 STSIRNGFQDSPCEDEWESRFYFHPISDLPPP 465
           ++S R     +P     E+    +     PPP
Sbjct: 639 TSSRRPLLLRAPQFTPSEAHLKIYESVLTPPP 670



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 85/315 (26%), Positives = 116/315 (36%), Gaps = 53/315 (16%)

Query: 107 GMPKLRSTANRDNDSG-----GSRPPLLPPGGRSTSAKPFSPPSGPG---------RFPV 152
           G P L  +   + ++      G+ PP   P   +      SP   P          +F +
Sbjct: 470 GRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLKNIRQFIM 529

Query: 153 PSPGHRSG----PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPG 208
           P    RS      P    +  PP  P V   P  + PP+ ++P P+   P      PVP 
Sbjct: 530 PVVSARSSRVIKTPRRFMDEDPPKPPKVEVSP-VLRPPITTSP-PVPQEP-----APVPS 582

Query: 209 GPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSS-SPFSNRPPLPPTPSRALDDKPPPP 267
            PR P+P  TP P P  R + L   + R + L+    P    PP PP PS      PPP 
Sbjct: 583 PPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPS------PPPA 636

Query: 268 PPPVGNRPSIHREAVPPPPPQNNK-PPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSS 326
           P     RP + R     P   + K      TP P  + +AP P PPP+   P    P + 
Sbjct: 637 PATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPRAV 696

Query: 327 GNDETPRLPQ----RNLSLSSSTPPLPSPGRS-GP------LPP---------PPSERPP 366
           G      LP+        + +   P  +P  S GP      L P         P +  PP
Sbjct: 697 GRTNHLSLPRFAPVVTTPVKAEVSPHGAPALSNGPQTQAQLLQPLQALQTQLLPQALPPP 756

Query: 367 PPVRDPPGRSGPLPP 381
            P   PP     +PP
Sbjct: 757 QPQLQPPPSPQQMPP 771



 Score = 75.9 bits (185), Expect = 8e-14
 Identities = 90/351 (25%), Positives = 112/351 (31%), Gaps = 77/351 (21%)

Query: 130 PPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPS 189
           P   RS + +P +P    GR     PG  +GP   ++  +      V       PPPV  
Sbjct: 203 PQAPRSRACEPSTPRRSRGR----PPGRPAGPCRRKQQAVVVAEAAVTIPKPEPPPPVVP 258

Query: 190 TPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGG------------SIRQ 237
                 S     G  P PG PR+   G +     G RG   GGG             ++ 
Sbjct: 259 VKHQTGSWKCKEGPGPGPGTPRRG--GQSSRGGRGGRGRGRGGGLPFVIKFVSRAKKVKM 316

Query: 238 SPLS-----SSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSI--------HREAVPP 284
             LS           +       P R +       P        +          E    
Sbjct: 317 GQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQKLDDEEEEKKEEEEKDK 376

Query: 285 PPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSS 344
              +  +  V     P+A  +    PPPP  P P P PP                     
Sbjct: 377 EGEEKEERAVAEEMMPAAEKEEAKLPPPPLTP-PAPSPP--------------------- 414

Query: 345 TPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSR 404
            PPLP P  S P  PP    PPPPV  PP    P PPPPP       S   P  P   S 
Sbjct: 415 -PPLPPPSTSPP--PPLCPPPPPPVSPPP---LPSPPPPPAQEEQEESPP-PVVPATCS- 466

Query: 405 SGVDSPRSGPRPPLPPDR----------PSAGAPPPPPPSTSIRNGFQDSP 445
                 R   RPPL P +          P   +PP P PST+     +DSP
Sbjct: 467 ------RKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSP 511



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 125/483 (25%), Positives = 151/483 (31%), Gaps = 158/483 (32%)

Query: 93   GGGGPPGLGGLFQAGMPKLRSTA-NRD---NDSGGSRPPLLPPG--GRSTSAKPFSP--- 143
            GG  PP    +   G P+  S   N D       GS PP  P    G       +SP   
Sbjct: 1816 GGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRR 1875

Query: 144  PSGPGRF-PVPSPGHRSG-------------PPEPQRNRMPPPRPDVGSKPDSIPPPVPS 189
            P G   F P+PSPG  S              P  P+R+R P P           PPP   
Sbjct: 1876 PLGGVSFGPLPSPGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPR-------PPPSRW 1928

Query: 190  TPRPIQSSPHNRGSPPVP---------GGPRQPSPGPTPPP------------------- 221
               P+++SP  R  PP           G    P P P+PPP                   
Sbjct: 1929 ASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDMEVVSGLSA 1988

Query: 222  --------------------FPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALD 261
                                  G  G++ GG     S    SSP S     P T   A  
Sbjct: 1989 ADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPG--DSSEEESSPTSRYIHFPVTVVSAPG 2046

Query: 262  DKPPPPPPP--------VGNRPSIHREAVPPPPPQNNKPPVPSTPRP----SASSQAPPP 309
              P   P          V +      EAV  P  Q   P  P   R     +A  +A PP
Sbjct: 2047 LAPSATPGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVVRAGVLGAAGDRARPP 2106

Query: 310  PPPPSR----------------PGP-----PPLPPSSSGNDETPRLPQRNLSLSSSTPP- 347
               PS                  GP     PP PP ++G+      P + L+ S + P  
Sbjct: 2107 EDLPSEIVDFVLKNLGGPGDGGAGPREESLPPAPPLANGSQ-----PSQGLTASPADPTR 2161

Query: 348  ----LP-SPG----RSGPLPPPPS-----------------------ERPPPPVRDPPGR 375
                LP +PG      GP P PP                        E  PPPV+ PP  
Sbjct: 2162 TFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVPPPVKQPP-- 2219

Query: 376  SGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPST 435
                  PP +S    TS  LP  P L     V   R  P PP PP      + P  PP  
Sbjct: 2220 -----LPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGPASPPRQ 2274

Query: 436  SIR 438
            +IR
Sbjct: 2275 AIR 2277



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 72/240 (30%), Positives = 84/240 (35%), Gaps = 55/240 (22%)

Query: 264 PPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPP 323
           PPP  PP  + P       PP PP +  PP P  P P      PPP  PP  P PPP P 
Sbjct: 403 PPPLTPPAPSPP-------PPLPPPSTSPPPPLCPPP------PPPVSPPPLPSPPPPPA 449

Query: 324 SSSGNDETPRLPQRNLSLSSSTPPL-PS------PGRSGPL-PPPPSERPPPPVRDPPGR 375
                +  P +     S     PPL PS        R+GP    PP+  P      PP  
Sbjct: 450 QEEQEESPPPVVPATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPED 509

Query: 376 SGPLPPP-------------PPVSRNGS----TSRAL----PATPQLPSRSGVDSPRSGP 414
           S  + P              P VS   S    T R      P  P     S V  P    
Sbjct: 510 SPTVAPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEVSPVLRPPITT 569

Query: 415 RPPLPPDRPSAGAPP--PPPPSTSI-----RNGFQDSPCEDEWESRFYFHPISDLPPPEP 467
            PP+P +     +PP  P PPST +     R      P    W S        +LPPP P
Sbjct: 570 SPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREP-TFRWTSL-----TRELPPPPP 623



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 102/381 (26%), Positives = 129/381 (33%), Gaps = 61/381 (16%)

Query: 137  SAKPFSPPSGPGRFPVPSPGHRSGPPE---PQRNRMPPPRPDVGSKPDSIPPPVPSTPRP 193
            S  P S P G    P+ +     G PE   P +N  PP RPD G    S PPP P     
Sbjct: 1807 SPAPSSEPPGGEDPPLDTDVLVPGAPERHSPIQNLDPPLRPDSG----SAPPPAP----- 1857

Query: 194  IQSSPHNRGSPPVPGGPRQPSPGPT--PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPP 251
             +S    R   P     R+P  G +  P P PG+            S L+   P    P 
Sbjct: 1858 -RSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGS-----------PSSLTHHIPTVGDPD 1905

Query: 252  LPPTPSRALDDKPPPPPPPVGNRPSIHREAVPP--PPPQNNKPPVPS--TPRPSASSQAP 307
             P  P R+    P  P PP    PS  R A PP    PQ   PP  S  T     S +  
Sbjct: 1906 FPAPPRRSRRPSPLAPRPP----PS--RWASPPLKTSPQLRVPPPTSVVTALTPTSGELA 1959

Query: 308  PPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSS---TPP----LPSPGRSGPLPPP 360
            PP P PS P P  L P     +    L   +L  ++S   T P    + + G  G     
Sbjct: 1960 PPGPAPSPPPPEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGG 2019

Query: 361  PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420
            P +        P  R     P   VS  G    A P  P++    GVD         +  
Sbjct: 2020 PGDSSEEE-SSPTSRYIHF-PVTVVSAPGLAPSATPGAPRIEQLDGVDDGTDSEAEAV-- 2075

Query: 421  DRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPSKLA 480
             +P     PP  P   +R G   +  +                PPE        +  K  
Sbjct: 2076 QQPRGQGTPPSGPGV-VRAGVLGAAGD-------------RARPPEDLPSEIVDFVLKNL 2121

Query: 481  RNESRSGSNRRERGAPPLPPI 501
                  G+  RE   PP PP+
Sbjct: 2122 GGPGDGGAGPREESLPPAPPL 2142



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 56/161 (34%), Positives = 66/161 (40%), Gaps = 48/161 (29%)

Query: 280 EAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNL 339
           EA  PPPP    PP PS P        PP PPP + P PP  PP        P  P    
Sbjct: 398 EAKLPPPPLT--PPAPSPP--------PPLPPPSTSPPPPLCPP--------PPPP---- 435

Query: 340 SLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATP 399
               S PPLPSP             PPPP ++    S    PPP V    S  R  P  P
Sbjct: 436 ---VSPPPLPSP-------------PPPPAQEEQEES----PPPVVPATCSRKRGRP--P 473

Query: 400 QLPS-RSGVDSPRSGPR---PPLPPDRPSAGAPPPPPPSTS 436
             PS R+  ++ R+GP    PP P    + G PP   P+ +
Sbjct: 474 LTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVA 514



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 126/513 (24%), Positives = 172/513 (33%), Gaps = 126/513 (24%)

Query: 61  KPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFG-GGGPPG-------LGGLFQAGMPKLR 112
           +P+GAG GGG GG G G          GGG+ G GG  PG       L GL + G+ +LR
Sbjct: 23  RPRGAGGGGGRGGRGNGAERVRVALRRGGGATGPGGAEPGEDTALLRLLGL-RRGLRRLR 81

Query: 113 STANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPP 172
                      + P +    GR           GP R  VP      G  + +  +    
Sbjct: 82  RL--------WAGPRVQRGRGRGRGR-----GWGPSRGCVPEEESSDGESDEEEFQ---- 124

Query: 173 RPDVGSKPDSIPPPVPSTPRPIQS-SPHNRG----SPPVPGGPRQPSPGPTPPPFP---- 223
                S  D  P  + S  R  +  +P  RG    + P+P  PR     PTPP  P    
Sbjct: 125 --GFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLP-PPRLADVAPTPPKTPARKR 181

Query: 224 GNRGTALGGGSIRQSPLSSSSPFS--NRPPLPPTPSRALDDKPPPPPPPVGNRPS---IH 278
           G  GT     ++ +    + +P +  +R   P TP R+    P  P  P   +     + 
Sbjct: 182 GEEGTERMVQALTELLRRAQAPQAPRSRACEPSTPRRSRGRPPGRPAGPCRRKQQAVVVA 241

Query: 279 REAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRP-------------------GPP 319
             AV  P P+   P VP   +  +      P P P  P                   G  
Sbjct: 242 EAAVTIPKPEPPPPVVPVKHQTGSWKCKEGPGPGPGTPRRGGQSSRGGRGGRGRGRGGGL 301

Query: 320 PLPPSSSGNDETPRLPQRNLSLSS---------STPPLP----SPGRSG---------PL 357
           P         +  ++ Q +L L S         S   +P      G+ G          L
Sbjct: 302 PFVIKFVSRAKKVKMGQLSLGLESGQGQGQHEESWQDVPQRRVGSGQGGSPCWKKQEQKL 361

Query: 358 PPPPSERPPPPVRDPPG-----RSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRS 412
                E+     +D  G     R+      P   +  +     P TP  PS         
Sbjct: 362 DDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAPS--------- 412

Query: 413 GPRPPLPPDRPSAGAPPP--PPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQ 470
            P PPLPP  PS   PPP  PPP   +      SP            P+   PPP    +
Sbjct: 413 -PPPPLPP--PSTSPPPPLCPPPPPPV------SP-----------PPLPSPPPPPAQEE 452

Query: 471 TTKSYPSKLARNESRSGSNRRERGAPPLPPIPR 503
             +S P  +    S      R+RG PPL P  R
Sbjct: 453 QEESPPPVVPATCS------RKRGRPPLTPSQR 479



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 41/153 (26%), Positives = 51/153 (33%), Gaps = 7/153 (4%)

Query: 303  SSQAPPPPPPPSRP----GPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLP 358
            S +A P PP P R     GP     +  G +E   L QR  S        PS        
Sbjct: 1035 SPEASPGPPGPRRGAGAGGPREEVVAHPGPEEQDSLLQRK-SARRCVKQRPSYDIFEDSD 1093

Query: 359  PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPL 418
                  PP P R  P R   LP P P  ++      L    QL +R  +D     P P  
Sbjct: 1094 DSEPGGPPAPRRRTP-RENELPLPEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFA 1152

Query: 419  PPDRPSAGAPPPPPPSTSIRNGF-QDSPCEDEW 450
                   G    P     +R  F +D   E+ W
Sbjct: 1153 SFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVW 1185



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 10/10 (100%), Positives = 10/10 (100%)

Query: 4   PPPPAPPPPP 13
           PPPPAPPPPP
Sbjct: 620 PPPPAPPPPP 629



 Score = 29.6 bits (65), Expect = 6.7
 Identities = 11/29 (37%), Positives = 15/29 (51%)

Query: 2   PVPPPPAPPPPPTFALANTEKPTLNKTEQ 30
           P PPPP  P PP     ++ +P L +  Q
Sbjct: 623 PAPPPPPAPSPPPAPATSSRRPLLLRAPQ 651


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
           tract binding protein associated) [Homo sapiens]
          Length = 707

 Score =  111 bits (277), Expect = 2e-24
 Identities = 99/325 (30%), Positives = 123/325 (37%), Gaps = 61/325 (18%)

Query: 60  DKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDN 119
           D+ +  G GGGG          GGGGG GG       PPG+      G+ + R       
Sbjct: 4   DRFRSRGGGGGGFH------RRGGGGGRGGLHDFRSPPPGM------GLNQNRGPMGPGP 51

Query: 120 DSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGP-PEPQRNRMPPPRPDVGS 178
              G +PP+ PP       +P  PP  P   P   P H+  P P+P + + PPP P   S
Sbjct: 52  GQSGPKPPIPPPPPHQQQQQP--PPQQPP--PQQPPPHQPPPHPQPHQQQQPPPPPQDSS 107

Query: 179 KPDSIPPPVPST---PRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSI 235
           KP     P P+      P  SS     +PP  G P    PGPTP P              
Sbjct: 108 KPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTP-------------- 153

Query: 236 RQSPLSSSSPFSNRPPLPPTPSRALDDKPP----PPPPPVGNRPSIHREAVPPPPPQNNK 291
              P  +S+P    PP P  PS  +   PP    PPPPP          AVP P P   +
Sbjct: 154 --PPAVTSAPPGAPPPTP--PSSGVPTTPPQAGGPPPPPA---------AVPGPGPGPKQ 200

Query: 292 PPVPSTPRPSASSQAPPPPPPP--SRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLP 349
            P P  P+       P P   P  S PG  P PP   G +  PR  +++       PP  
Sbjct: 201 GPGPGGPKGGKMPGGPKPGGGPGLSTPGGHPKPPHRGGGE--PRGGRQH------HPPYH 252

Query: 350 SPGRSGPLPPPPSERPPPPVRDPPG 374
                GP P  P  R    + D  G
Sbjct: 253 QQHHQGPPPGGPGGRSEEKISDSEG 277



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 86/262 (32%), Positives = 109/262 (41%), Gaps = 63/262 (24%)

Query: 190 TPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNR 249
           +P P      NRG  P+  GP Q  P P  PP P ++         +Q P          
Sbjct: 33  SPPPGMGLNQNRG--PMGPGPGQSGPKPPIPPPPPHQQ--------QQQP---------- 72

Query: 250 PPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNN-KPPVPSTPRPS------- 301
           PP  P P +    +PPP P P       H++  PPPPPQ++ KP V   P P+       
Sbjct: 73  PPQQPPPQQPPPHQPPPHPQP-------HQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAP 125

Query: 302 -ASSQAPP--PP----PPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTP--PLPSPG 352
            ASS APP  PP    PP S PGP P PP                +++S+ P  P P+P 
Sbjct: 126 PASSSAPPATPPTSGAPPGSGPGPTPTPPP---------------AVTSAPPGAPPPTPP 170

Query: 353 RSG-PLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPR 411
            SG P  PP +  PPPP    PG  GP P   P    G     +P  P+     G+ +P 
Sbjct: 171 SSGVPTTPPQAGGPPPPPAAVPG-PGPGPKQGP-GPGGPKGGKMPGGPKPGGGPGLSTPG 228

Query: 412 SGPRPP-LPPDRPSAGAPPPPP 432
             P+PP      P  G    PP
Sbjct: 229 GHPKPPHRGGGEPRGGRQHHPP 250



 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 110/334 (32%), Positives = 124/334 (37%), Gaps = 92/334 (27%)

Query: 83  GGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPG-GRSTSAKPF 141
           GGGGGG    GGGG  G GGL     P                    PPG G + +  P 
Sbjct: 10  GGGGGGFHRRGGGG--GRGGLHDFRSP--------------------PPGMGLNQNRGPM 47

Query: 142 SPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNR 201
            P  GPG+         SGP  P    +PPP P    +      P P  P P Q  PH  
Sbjct: 48  GP--GPGQ---------SGPKPP----IPPPPPHQQQQQ-----PPPQQPPPQQPPPHQ- 86

Query: 202 GSPPVPGGPRQPSPGPTPPPFPGNR---------GTALGGGSIRQSPLSSSSPFSNRPPL 252
             PP P    QP     PPP P +          G A G GS    P SSS+P    P  
Sbjct: 87  -PPPHP----QPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGS--APPASSSAP----PAT 135

Query: 253 PPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP 312
           PPT        P P P P     S    A PP PP +    VP+TP P A     PPPPP
Sbjct: 136 PPTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSG---VPTTP-PQAGG---PPPPP 188

Query: 313 PSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVR-- 370
            + PGP P P    G    P  P+         P  P PG  GP    P   P PP R  
Sbjct: 189 AAVPGPGPGPKQGPG----PGGPK-----GGKMPGGPKPG-GGPGLSTPGGHPKPPHRGG 238

Query: 371 -DPPGRSGPLPP--------PPPVSRNGSTSRAL 395
            +P G     PP        PPP    G +   +
Sbjct: 239 GEPRGGRQHHPPYHQQHHQGPPPGGPGGRSEEKI 272



 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 59/169 (34%), Positives = 69/169 (40%), Gaps = 20/169 (11%)

Query: 272 GNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPP-PPPPPSRPGPPPLPPSSSGNDE 330
           G R  +H    PPP    N+   P  P P  S   PP PPPPP +    P P        
Sbjct: 23  GGRGGLHDFRSPPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQP 82

Query: 331 TPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGS 390
            P  P          PP P P +    PPPP +   P V   PG +  +   PP S    
Sbjct: 83  PPHQP----------PPHPQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPAS---- 128

Query: 391 TSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSA--GAPPPPPPSTSI 437
            S A PATP  P+         GP P  PP   SA  GAPPP PPS+ +
Sbjct: 129 -SSAPPATP--PTSGAPPGSGPGPTPTPPPAVTSAPPGAPPPTPPSSGV 174



 Score = 32.7 bits (73), Expect = 0.79
 Identities = 26/93 (27%), Positives = 34/93 (36%), Gaps = 10/93 (10%)

Query: 69  GGGGGFGGGGGFGGGGGG----GGGGSFGGGGPPGL------GGLFQAGMPKLRSTANRD 118
           GGGG    G  +G GG      GGGG  G    PG+      G +  + M   R      
Sbjct: 613 GGGGAMNMGDPYGSGGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMRTERFGQGGA 672

Query: 119 NDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFP 151
              GG  P  + PG  +   +      GP + P
Sbjct: 673 GPVGGQGPRGMGPGTPAGYGRGREEYEGPNKKP 705


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score =  111 bits (277), Expect = 2e-24
 Identities = 121/421 (28%), Positives = 146/421 (34%), Gaps = 83/421 (19%)

Query: 103 LFQAGMPKLRSTANRDNDSGGSRP--PLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG 160
           + QA  P L++          + P  P LP  G + SA    P   P     P+      
Sbjct: 179 MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT 238

Query: 161 PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVP------------- 207
            P P  +    P       P   PPP PS   P+Q    + G P  P             
Sbjct: 239 APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP 298

Query: 208 ------GGPRQPSPGPTPP---PFPGNRGTALGGGS--------IRQSPLSSSSPFSNRP 250
                  GP    PGP  P   P   ++G A  G S          Q P S S+  S +P
Sbjct: 299 GPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQP 358

Query: 251 ----PLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306
               PLPP P      KPPP  P     P +      P P  +  PP  S P P + +  
Sbjct: 359 PREQPLPPAPLAMPHIKPPPTTP----IPQL------PAPQAHKHPPHLSGPSPFSMNAN 408

Query: 307 PPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS-----PG--RSGPLPP 359
            PPPP          P SS      P      L L   + PLPS     PG  +S  LPP
Sbjct: 409 LPPPPALK-------PLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPP 461

Query: 360 PPSERP----------PPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGV-- 407
           PP+  P          PP  + P    GP P  PP   + ST  A P T   P  SG   
Sbjct: 462 PPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAA 521

Query: 408 --DSPRSGPRPPLP---------PDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYF 456
              S   G   PLP          D     +PPPPP S S      D+P      +RFY 
Sbjct: 522 SGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYK 581

Query: 457 H 457
           H
Sbjct: 582 H 582



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 94/325 (28%), Positives = 114/325 (35%), Gaps = 58/325 (17%)

Query: 218 TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSI 277
           T P  P  +       S  Q  +  + P + + P   TP+ +      P  P  G  PS 
Sbjct: 157 TSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPS- 215

Query: 278 HREAVPPP----------PPQNNKPPVPST---PRPSASSQAPPPPPPPSRPGP-PPLPP 323
              AVPP            PQ    PVP T     P+   Q PP P PP  P P PPL P
Sbjct: 216 -ATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQP 274

Query: 324 --SSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPP 381
              S+G    P   Q    L    PP P   ++GPL   P   PP P   PP  S    P
Sbjct: 275 LTGSAGQPSAPSHAQP--PLHGQGPPGPHSLQAGPLLQHPG--PPQPFGLPPQASQGQAP 330

Query: 382 --PPPVSRNGSTSRALPATPQLPSRSGVDS---PRSGPRPPLPPDRPSAGAPP------- 429
               P +    TS  LPA     S+S + S   PR  P PP P   P    PP       
Sbjct: 331 LGTSPAAAYPHTSLQLPA-----SQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQL 385

Query: 430 --------PP----PPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPS 477
                   PP    P   S+       P      S    HP S  PPP   +  ++  PS
Sbjct: 386 PAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPS 445

Query: 478 KLARNESRSGSNRRERGAPPLPPIP 502
             A+    + S         LPP P
Sbjct: 446 SPAQPPGLTQSQN-------LPPPP 463


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  111 bits (277), Expect = 2e-24
 Identities = 121/421 (28%), Positives = 146/421 (34%), Gaps = 83/421 (19%)

Query: 103  LFQAGMPKLRSTANRDNDSGGSRP--PLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG 160
            + QA  P L++          + P  P LP  G + SA    P   P     P+      
Sbjct: 733  MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT 792

Query: 161  PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVP------------- 207
             P P  +    P       P   PPP PS   P+Q    + G P  P             
Sbjct: 793  APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP 852

Query: 208  ------GGPRQPSPGPTPP---PFPGNRGTALGGGS--------IRQSPLSSSSPFSNRP 250
                   GP    PGP  P   P   ++G A  G S          Q P S S+  S +P
Sbjct: 853  GPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQP 912

Query: 251  ----PLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306
                PLPP P      KPPP  P     P +      P P  +  PP  S P P + +  
Sbjct: 913  PREQPLPPAPLAMPHIKPPPTTP----IPQL------PAPQAHKHPPHLSGPSPFSMNAN 962

Query: 307  PPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS-----PG--RSGPLPP 359
             PPPP          P SS      P      L L   + PLPS     PG  +S  LPP
Sbjct: 963  LPPPPALK-------PLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPP 1015

Query: 360  PPSERP----------PPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGV-- 407
            PP+  P          PP  + P    GP P  PP   + ST  A P T   P  SG   
Sbjct: 1016 PPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAA 1075

Query: 408  --DSPRSGPRPPLP---------PDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYF 456
               S   G   PLP          D     +PPPPP S S      D+P      +RFY 
Sbjct: 1076 SGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYK 1135

Query: 457  H 457
            H
Sbjct: 1136 H 1136



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 94/325 (28%), Positives = 114/325 (35%), Gaps = 58/325 (17%)

Query: 218  TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSI 277
            T P  P  +       S  Q  +  + P + + P   TP+ +      P  P  G  PS 
Sbjct: 711  TSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPS- 769

Query: 278  HREAVPPP----------PPQNNKPPVPST---PRPSASSQAPPPPPPPSRPGP-PPLPP 323
               AVPP            PQ    PVP T     P+   Q PP P PP  P P PPL P
Sbjct: 770  -ATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQP 828

Query: 324  --SSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPP 381
               S+G    P   Q    L    PP P   ++GPL   P   PP P   PP  S    P
Sbjct: 829  LTGSAGQPSAPSHAQP--PLHGQGPPGPHSLQAGPLLQHPG--PPQPFGLPPQASQGQAP 884

Query: 382  --PPPVSRNGSTSRALPATPQLPSRSGVDS---PRSGPRPPLPPDRPSAGAPP------- 429
                P +    TS  LPA     S+S + S   PR  P PP P   P    PP       
Sbjct: 885  LGTSPAAAYPHTSLQLPA-----SQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQL 939

Query: 430  --------PP----PPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPS 477
                    PP    P   S+       P      S    HP S  PPP   +  ++  PS
Sbjct: 940  PAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPS 999

Query: 478  KLARNESRSGSNRRERGAPPLPPIP 502
              A+    + S         LPP P
Sbjct: 1000 SPAQPPGLTQSQN-------LPPPP 1017


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score =  111 bits (277), Expect = 2e-24
 Identities = 121/421 (28%), Positives = 146/421 (34%), Gaps = 83/421 (19%)

Query: 103  LFQAGMPKLRSTANRDNDSGGSRP--PLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG 160
            + QA  P L++          + P  P LP  G + SA    P   P     P+      
Sbjct: 733  MLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT 792

Query: 161  PPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVP------------- 207
             P P  +    P       P   PPP PS   P+Q    + G P  P             
Sbjct: 793  APVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPP 852

Query: 208  ------GGPRQPSPGPTPP---PFPGNRGTALGGGS--------IRQSPLSSSSPFSNRP 250
                   GP    PGP  P   P   ++G A  G S          Q P S S+  S +P
Sbjct: 853  GPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQP 912

Query: 251  ----PLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306
                PLPP P      KPPP  P     P +      P P  +  PP  S P P + +  
Sbjct: 913  PREQPLPPAPLAMPHIKPPPTTP----IPQL------PAPQAHKHPPHLSGPSPFSMNAN 962

Query: 307  PPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS-----PG--RSGPLPP 359
             PPPP          P SS      P      L L   + PLPS     PG  +S  LPP
Sbjct: 963  LPPPPALK-------PLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPP 1015

Query: 360  PPSERP----------PPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGV-- 407
            PP+  P          PP  + P    GP P  PP   + ST  A P T   P  SG   
Sbjct: 1016 PPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAA 1075

Query: 408  --DSPRSGPRPPLP---------PDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYF 456
               S   G   PLP          D     +PPPPP S S      D+P      +RFY 
Sbjct: 1076 SGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTPSHASQSARFYK 1135

Query: 457  H 457
            H
Sbjct: 1136 H 1136



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 94/325 (28%), Positives = 114/325 (35%), Gaps = 58/325 (17%)

Query: 218  TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSI 277
            T P  P  +       S  Q  +  + P + + P   TP+ +      P  P  G  PS 
Sbjct: 711  TSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPS- 769

Query: 278  HREAVPPP----------PPQNNKPPVPST---PRPSASSQAPPPPPPPSRPGP-PPLPP 323
               AVPP            PQ    PVP T     P+   Q PP P PP  P P PPL P
Sbjct: 770  -ATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQP 828

Query: 324  --SSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPP 381
               S+G    P   Q    L    PP P   ++GPL   P   PP P   PP  S    P
Sbjct: 829  LTGSAGQPSAPSHAQP--PLHGQGPPGPHSLQAGPLLQHPG--PPQPFGLPPQASQGQAP 884

Query: 382  --PPPVSRNGSTSRALPATPQLPSRSGVDS---PRSGPRPPLPPDRPSAGAPP------- 429
                P +    TS  LPA     S+S + S   PR  P PP P   P    PP       
Sbjct: 885  LGTSPAAAYPHTSLQLPA-----SQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQL 939

Query: 430  --------PP----PPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTKSYPS 477
                    PP    P   S+       P      S    HP S  PPP   +  ++  PS
Sbjct: 940  PAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPS 999

Query: 478  KLARNESRSGSNRRERGAPPLPPIP 502
              A+    + S         LPP P
Sbjct: 1000 SPAQPPGLTQSQN-------LPPPP 1017


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score =  110 bits (274), Expect = 4e-24
 Identities = 96/341 (28%), Positives = 124/341 (36%), Gaps = 56/341 (16%)

Query: 130  PPGGRSTSAKPFSPPSGPGRFPV-PSPGHRSGPPEPQRNRMPP---PRPDVGSKPDSIPP 185
            PP   +T+  P + PS P      P P     PP       PP   P P + +     P 
Sbjct: 1408 PPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPT 1467

Query: 186  PVPSTPRPIQSSPHNRGSPPV-----PGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL 240
              PS P    S P    SPP      P     PSP  T P  P    T L   +    P 
Sbjct: 1468 TTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPT 1527

Query: 241  SSS---------SPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNK 291
            +++         SP +  P  PPT +  L     P PPP             PPP     
Sbjct: 1528 TTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPT--------TTTTPPPTTTPS 1579

Query: 292  PPVPSTPRP-SASSQAPPP-------------PPPPSRPGPPPLPPSSSGNDETPRLPQR 337
            PP  +TP P + ++  PPP             PPP + P PP   P       TP  P  
Sbjct: 1580 PPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPI------TP--PTS 1631

Query: 338  NLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVR---DPPGRSGPLPPPPPVSRNGSTSRA 394
              +L  +T P P P  +    PPP+  P PP      PP  +   PPP     +  T+  
Sbjct: 1632 TTTLPPTTTPSPPP--TTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTP 1689

Query: 395  LPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPST 435
             P T  + + S   +P S   P      PS+   P PPP+T
Sbjct: 1690 SPPTTTMTTPSPTTTPSS---PITTTTTPSSTTTPSPPPTT 1727



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 87/339 (25%), Positives = 122/339 (35%), Gaps = 43/339 (12%)

Query: 109  PKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRS--GPPEPQR 166
            P + +T      +  S P   P    +T + P +  + P     PSP   +   PP    
Sbjct: 1456 PPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTT 1515

Query: 167  NRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNR 226
               P   P   +   + PPP  +TP P  ++P    +PP       P+  P+PPP     
Sbjct: 1516 TLPPTTTPSPPTTTTTTPPPT-TTPSPPTTTPI---TPPTSTTTLPPTTTPSPPPTT--- 1568

Query: 227  GTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPP 286
                   +    P ++ SP +   P PPT +         P PP     +      P PP
Sbjct: 1569 -------TTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPP 1621

Query: 287  PQNN-KPPVPSTPRPSASSQAPPP-----PPPPSRPGPP----PLPPSSSGNDETPRLPQ 336
                  PP  +T  P  ++ +PPP     PPP + P PP    P PP +     T   P 
Sbjct: 1622 TTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPIT-----TTTTPP 1676

Query: 337  RNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALP 396
               + SS     PSP  +    P P+  P  P+      S    P PP           P
Sbjct: 1677 PTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPP-----------P 1725

Query: 397  ATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPP-PPS 434
             T   PS +   SP +     LPP   S+     P PPS
Sbjct: 1726 TTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPS 1764



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 85/329 (25%), Positives = 119/329 (36%), Gaps = 53/329 (16%)

Query: 130  PPGGRSTSAKPFSPPSGPGRFPVPSPGHRSG------PPEPQRNRMPPPRPDVGSKPDSI 183
            PP   +T+  P + PS P   P+  P   +       P  P      PP     S P + 
Sbjct: 1486 PPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTT 1545

Query: 184  P--PPVPSTPRPIQSSPHNRGSPP-----VPGGPRQPSPGPTPPPFPGNRGTALGGGSIR 236
            P  PP  +T  P  ++P    SPP      P     PSP  T  P P    T     +  
Sbjct: 1546 PITPPTSTTTLPPTTTP----SPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTT 1601

Query: 237  QSP--LSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPV 294
             SP   ++++P     P PPT +        P  PP             PPP     PP 
Sbjct: 1602 PSPPTTTTTTPPPTTTPSPPTTT--------PITPPTSTTTLPPTTTPSPPPTTTTTPPP 1653

Query: 295  PSTPRPSASSQAPPP------PPPPSRPGPP----PLPPSSSGNDETPRLPQRNLSLSSS 344
             +TP P  ++   PP      PPP + P  P    P PP+++    +P     +   +++
Sbjct: 1654 TTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTT 1713

Query: 345  TP---PLPSPGRSGPLPPPPSERP----------PPPVRDPPGRSGPLPP---PPPVSRN 388
            TP     PSP  +    P P+  P          PP     P  + PLPP   PP  S  
Sbjct: 1714 TPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTFSPF 1773

Query: 389  GSTSRALPATPQLPSRSGVDSPRSGPRPP 417
             +T+   P  P       +DS +     P
Sbjct: 1774 STTTPTTPCVPLCNWTGWLDSGKPNFHKP 1802



 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 78/296 (26%), Positives = 106/296 (35%), Gaps = 41/296 (13%)

Query: 130  PPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIP-PPVP 188
            PP   +T+  P + PS P   P+  P   +  P P     PPP       P + P PP  
Sbjct: 1525 PPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLP-PTTTPSPPPTTTTTPPPTTTPSPPTT 1583

Query: 189  STPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSN 248
            +TP P   +     +PP    P  P+   T PP                 P ++ SP + 
Sbjct: 1584 TTPSPPTITTT---TPPPTTTPSPPTTTTTTPP-----------------PTTTPSPPTT 1623

Query: 249  RPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPP 308
             P  PPT +  L     P PPP             PPP     PP  +TP P  ++   P
Sbjct: 1624 TPITPPTSTTTLPPTTTPSPPPT--------TTTTPPPTTTPSPPTTTTPSPPITTTTTP 1675

Query: 309  PPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSP-GRSGPLPPPPSERPPP 367
            PP   +     P+  + S    T   P    + SS      +P   + P PPP +   P 
Sbjct: 1676 PP---TTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPS 1732

Query: 368  PVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRP 423
            P   P   +  +   PP     +TS  L  TP  PS   +  P   P     P  P
Sbjct: 1733 PTTTPSPPTTTMTTLPPT----TTSSPLTTTPLPPS---ITPPTFSPFSTTTPTTP 1781



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 69/256 (26%), Positives = 100/256 (39%), Gaps = 38/256 (14%)

Query: 213  PSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPP---- 268
            PSP  T P  P    T L   +    P ++++     PP   TPS  +     PPP    
Sbjct: 1399 PSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTT----PPPTTTPSPPITTTTTPPPTTTP 1454

Query: 269  -PPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSG 327
             PP+    +      P PP     PP  +   P+ ++  PPP   PS P   P+ P +S 
Sbjct: 1455 SPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPAST 1514

Query: 328  NDETPRLPQRNLSLSSSTPP---LPSPGRSGPLPPP-------PSERPPPP---VRDPPG 374
                P       + +++TPP    PSP  + P+ PP       P+  P PP      PP 
Sbjct: 1515 TTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPP 1574

Query: 375  RSGPLPP------PPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPP-----LPPDRP 423
             + P PP      PP ++         P+ P   + +    P + P PP      PP   
Sbjct: 1575 TTTPSPPTTTTPSPPTITTTTPPPTTTPSPP--TTTTTTPPPTTTPSPPTTTPITPPTST 1632

Query: 424  SAGAP---PPPPPSTS 436
            +   P   P PPP+T+
Sbjct: 1633 TTLPPTTTPSPPPTTT 1648



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 60/195 (30%), Positives = 78/195 (40%), Gaps = 30/195 (15%)

Query: 262  DKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPP---PPPP---SR 315
            DK    P P    PS      PPP      PP  +   P+ ++  PPP   P PP   + 
Sbjct: 1393 DKCITTPSPPTTTPS------PPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTT 1446

Query: 316  PGPPPLPPSSSGNDETPRLPQRNLSLSSSTP----PLPSPGRSGPLPPPPSERPPPPVR- 370
              PP   PS   +  T   P    S  ++TP      PSP  +    PPP+  P PP   
Sbjct: 1447 TPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTT 1506

Query: 371  --DPPGRSGPLPPPPPVSRNGSTSRALP--ATPQLPSRSGVDSPRSGPRPPLPPDRPSAG 426
               PP  +  LPP    S   +T+   P   TP  P+ + +  P S    P P   PS  
Sbjct: 1507 PITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLP-PTTTPS-- 1563

Query: 427  APPP-----PPPSTS 436
             PPP     PPP+T+
Sbjct: 1564 -PPPTTTTTPPPTTT 1577



 Score = 66.2 bits (160), Expect = 6e-11
 Identities = 79/335 (23%), Positives = 122/335 (36%), Gaps = 42/335 (12%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 3962 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 4020

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 4021 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 4078

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNN 290
                  Q+P  +++P +    + PTP+        P   P+    ++     P P P   
Sbjct: 4079 ------QTP--TTTPITTTTTVTPTPTPT--GTQTPTTTPITTTTTV----TPTPTPTGT 4124

Query: 291  KPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS 350
            + P   T  P  ++    P P P+    P   P ++    TP  P    + + +T P+ +
Sbjct: 4125 QTP---TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT-PTPTGTQTPTTTPITT 4180

Query: 351  PGRSGPLPPPPSERPPPPVRDPPGRSGPLPP--PPPVSRNGSTSRAL--PATPQLPSRSG 406
                 P P P   +  PP          L    PPP S    TSR+   P T      S 
Sbjct: 4181 TTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLST 4240

Query: 407  VD-----SPRSGPRPPLPPDRPSAGAPPPPPPSTS 436
            +      +  + P  P  P   S G    PPPST+
Sbjct: 4241 LPPAIEMTSTAPPSTPTAPTTTSGGHTLSPPPSTT 4275



 Score = 59.3 bits (142), Expect = 8e-09
 Identities = 69/296 (23%), Positives = 107/296 (36%), Gaps = 34/296 (11%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 4031 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 4089

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 4090 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 4147

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNN 290
                  Q+P  +++P +    + PTP+        P   P+    ++     P P     
Sbjct: 4148 ------QTP--TTTPITTTTTVTPTPTPT--GTQTPTTTPITTTTTV--TPTPTPTGTQT 4195

Query: 291  KPPVPSTPRPSASSQAPPPPPPPSRPGPP-----PLPPSSSGNDETPRLPQRNLSLSSST 345
             PP  ++  P A      PPP  S P        PL  S++     P   +   +   ST
Sbjct: 4196 GPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPST 4255

Query: 346  PPLPSPGRSGPL--PPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATP 399
            P  P+    G    PPP +   PP        +G    P P +   +T+ A   TP
Sbjct: 4256 PTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTP 4311



 Score = 56.6 bits (135), Expect = 5e-08
 Identities = 82/350 (23%), Positives = 113/350 (32%), Gaps = 88/350 (25%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 4077 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 4135

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 4136 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQT 4195

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRA-------------LDDKPP--------PPPP 269
            G  +   +   +    SN PP   TP  +             L   PP        PP  
Sbjct: 4196 GPPTHTSTAPIAELTTSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPST 4255

Query: 270  PVGNRPSIHREAVPPPPPQNNKPP---------------VPSTPRPSASSQAPPPPPPPS 314
            P     +     + PPP     PP                PST + + +S   P P P S
Sbjct: 4256 PTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTPSTVQTTTTSAWTPTPTPLS 4315

Query: 315  RP------GPPPLPPS------------SSGNDE----------------TPRLPQRNLS 340
             P      G  P P S            + G +                 +  L   N S
Sbjct: 4316 TPSIIRTTGLRPYPSSVLICCVLNDTYYAPGEEVYNGTYGDTCYFVNCSLSCTLEFYNWS 4375

Query: 341  LSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPP--PPPVSRN 388
              S+  P P+P +S P P  PS  P  P    PG   P  P   PP   N
Sbjct: 4376 CPSTPSPTPTPSKSTPTPSKPSSTPSKPT---PGTKPPECPDFDPPRQEN 4422



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 74/349 (21%), Positives = 122/349 (34%), Gaps = 49/349 (14%)

Query: 109  PKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQ 165
            P   +T   +N +    PP   P   +T+  P   P+G   P   P+ +    +  P P 
Sbjct: 1882 PTTMTTTTTENPT----PPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 1937

Query: 166  RNRMPPPRPDVGSKPDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP---- 217
              + P   P + +     P P P+   TP     +     +P P P G + P+  P    
Sbjct: 1938 GTQTPTTTP-ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT 1996

Query: 218  -TPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPS 276
             T  P P   GT        Q+P  +++P +    + PTP+      P   P        
Sbjct: 1997 TTVTPTPTPTGT--------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTP-------- 2038

Query: 277  IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQ 336
            I       P P       P+T   + ++   P P P     P   P +++    TP  P 
Sbjct: 2039 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TPT 2096

Query: 337  RNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSRA 394
               + + +T P+ +     P P P   + P   P+      +   P P P      T+  
Sbjct: 2097 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTTP 2153

Query: 395  LPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
            +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 2154 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2202



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2007 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 2065

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 2066 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 2123

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 2124 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2175

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 2176 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 2233

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 2234 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 2290

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 2291 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2340



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2145 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 2203

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 2204 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 2261

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 2262 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2313

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 2314 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 2371

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 2372 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 2428

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 2429 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2478



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2283 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 2341

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 2342 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 2399

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 2400 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2451

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 2452 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 2509

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 2510 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 2566

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 2567 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2616



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2421 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 2479

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 2480 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 2537

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 2538 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2589

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 2590 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 2647

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 2648 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 2704

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 2705 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2754



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2559 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 2617

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 2618 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 2675

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 2676 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2727

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 2728 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 2785

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 2786 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 2842

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 2843 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 2892



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2697 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 2755

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 2756 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 2813

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 2814 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 2865

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 2866 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 2923

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 2924 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 2980

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 2981 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3030



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2835 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 2893

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 2894 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 2951

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 2952 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3003

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3004 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 3061

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 3062 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 3118

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 3119 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3168



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 2973 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 3031

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 3032 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 3089

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 3090 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3141

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3142 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 3199

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 3200 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 3256

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 3257 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3306



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 3111 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 3169

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 3170 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 3227

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 3228 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3279

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3280 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 3337

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 3338 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 3394

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 3395 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3444



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 3249 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 3307

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 3308 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 3365

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 3366 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3417

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3418 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 3475

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 3476 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 3532

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 3533 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3582



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 3387 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 3445

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 3446 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 3503

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 3504 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3555

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3556 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 3613

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 3614 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 3670

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 3671 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3720



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 3525 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 3583

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 3584 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 3641

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 3642 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3693

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3694 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 3751

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 3752 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 3808

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 3809 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3858



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 3663 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 3721

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 3722 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 3779

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 3780 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3831

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3832 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 3889

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 3890 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 3946

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 3947 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 3996



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 74/350 (21%), Positives = 122/350 (34%), Gaps = 52/350 (14%)

Query: 123  GSRPPLLPPGGRSTSAKPFSPPSG---PGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            G++ P   P   +T+  P   P+G   P   P+ +    +  P P   + P   P + + 
Sbjct: 3801 GTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP-ITTT 3859

Query: 180  PDSIPPPVPS---TPRPIQSSPHNRGSP-PVPGGPRQPSPGP-----TPPPFPGNRGTAL 230
                P P P+   TP     +     +P P P G + P+  P     T  P P   GT  
Sbjct: 3860 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT-- 3917

Query: 231  GGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPP-----------PPPPPVGNRPS--- 276
                  Q+P  +++P +    + PTP+      P            P P P G +     
Sbjct: 3918 ------QTP--TTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 3969

Query: 277  -IHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             I       P P       P+T   + ++   P P P     P   P +++    TP  P
Sbjct: 3970 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTT-TTVTP-TP 4027

Query: 336  QRNLSLSSSTPPLPSPGRSGPLPPPPSERPP--PPVRDPPGRSGPLPPPPPVSRNGSTSR 393
                + + +T P+ +     P P P   + P   P+      +   P P P      T+ 
Sbjct: 4028 TPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT---TTTVTPTPTPTGTQTPTTT 4084

Query: 394  ALPATPQL---PSRSGVDSPRSGP----RPPLPPDRPSAGAPPPPPPSTS 436
             +  T  +   P+ +G  +P + P        P   P+    P   P T+
Sbjct: 4085 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4134


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score =  109 bits (272), Expect = 7e-24
 Identities = 111/382 (29%), Positives = 134/382 (35%), Gaps = 41/382 (10%)

Query: 127  PLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPP 186
            P  PP      A PFSPP+ P   P  +P  ++ P         PP P           P
Sbjct: 664  PFSPPPSPPVQA-PFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATP 722

Query: 187  VPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPF 246
             P  P P+ + P     PP P      SP  TPPP              R  PL ++ P 
Sbjct: 723  PPQAPPPLAAPPLQ--VPPSPPASPPMSPSATPPP--------------RVPPLLAAPPL 766

Query: 247  SNRPPLPPTPSRALD----DKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSA 302
                 +PP+P  +L      KPPP  PP    P +     PP       P  PS   P +
Sbjct: 767  Q----VPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMS 822

Query: 303  SSQAPPPPPPPSRPGP----PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLP 358
                PPP  PP    P    PP PP+S       R P      S S P L      GP P
Sbjct: 823  PLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP-P 881

Query: 359  PPPSERPPPPVRDP--PGRSGPLPPPPPVSR--NGSTSRALPATPQLPSRSGVDSPRSGP 414
            PPPS  P   +  P   G S      P   R  +        A+P   +      P +  
Sbjct: 882  PPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWS 941

Query: 415  RPPLPP--DRPSAGAPPPPPPSTSIRNGFQDSPC---EDEWESRFYFHPISDLPPPEPYV 469
            R P PP   R + GAP P PP+T    G  D  C   E E        P +  P P P  
Sbjct: 942  RGPAPPLAFRGAPGAPLPWPPATG--PGSADGLCTIYETEGPESATPAPGALDPGPSPGT 999

Query: 470  QTTKSYPSKLARNESRSGSNRR 491
               K+     A   SRS    R
Sbjct: 1000 SGGKAAAGAGAGASSRSPKQAR 1021



 Score =  104 bits (259), Expect = 2e-22
 Identities = 102/336 (30%), Positives = 129/336 (38%), Gaps = 49/336 (14%)

Query: 155 PGHRSGPPEPQRNRMPPPRPDVGSKPDSIP----PPVPSTPRPIQSSPHNRGSPPVPGGP 210
           P   + PP      + PP     S P + P    PP P+ P P+Q+ P    +PP    P
Sbjct: 527 PASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPA-PCPLQAPPSPLTTPP----P 581

Query: 211 RQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPP 270
             PS   TPPP               Q+P + +SP     P PP    A    PPP  PP
Sbjct: 582 ETPSSIATPPP---------------QAPPALASPPLQGLPSPPLSPLAT---PPPQAPP 623

Query: 271 VGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQ---APPPPPPPSRPGPPPLPPSSSG 327
               P +     PP  P  +    PS   P+A +      P  PPPS P   P  P +S 
Sbjct: 624 XLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 683

Query: 328 NDETPRLPQRNLSLSSSTPPL---PSPGRSGPLPP--PPSERPPPPVRDPPGRSGPLPP- 381
                  P      S + PPL   PSP  S P+ P   P  + PPP+  PP +  P PP 
Sbjct: 684 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPA 743

Query: 382 PPPVSRNGS-TSRALPATPQLPSRSGVDSPRSGPRPPL---PPDRPSAGAPPP----PPP 433
            PP+S + +   R  P     P +     P S P  PL   PP  P A A PP    P P
Sbjct: 744 SPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSP 803

Query: 434 STSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYV 469
             S       SP      +     P++  PP  P V
Sbjct: 804 PASFPGQAPFSP-----SASLPMSPLATPPPQAPPV 834



 Score =  103 bits (257), Expect = 4e-22
 Identities = 119/405 (29%), Positives = 154/405 (38%), Gaps = 63/405 (15%)

Query: 126 PPLLPPGGRSTSAKPF-SPPSGPGRFPVP-SPGHRSGPPEPQRNRMPPPRPDVGSKPDSI 183
           PP  PP   S   +   SPP  P   P P +P   + PP        PP P        +
Sbjct: 591 PPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPP-----LQAPPSPPASPPLSPL 645

Query: 184 PPPVPSTPRPIQSSPHNRGSPPVPGGPRQP--SPGPTPPPFPGNRGTALGGGSIRQSPLS 241
             P P  P  +          P P  P Q   SP  +PP  P     +       Q+P S
Sbjct: 646 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPS-------QAPPS 698

Query: 242 SSSPFSNRPPLPP-TPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300
            ++P    PP PP +P  +    PPP  PP    P +    VPP PP +      +TP P
Sbjct: 699 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQ---VPPSPPASPPMSPSATPPP 755

Query: 301 SASS--QAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGR----- 353
                  APP   PPS P   P+ P +    + P         +  +PP   PG+     
Sbjct: 756 RVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP 815

Query: 354 SGPLPPPPSERPPPPVRDPPGRSGPL---PPPPPVSRNGSTSRALPATPQLPSRSGVDSP 410
           S  LP  P   PPP  + PP  + PL   PP PP S    T +A    P+ P   G D+ 
Sbjct: 816 SASLPMSPLATPPP--QAPPVLAAPLLQVPPSPPAS---PTLQA----PRRPPTPGPDTS 866

Query: 411 RSGPRPPLPPDRPSAGAPPPPP---PSTSIRN----GFQDSPCEDEWESRFYFHPISDLP 463
            SGPR  L      A  PPPPP   PS+++      G   S      E R Y     D  
Sbjct: 867 VSGPRLTL----ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGY-----DSG 917

Query: 464 P-------PEPYVQTTKSYPSKLARNESRSGSNRRERGAP-PLPP 500
           P       P P  +    +P+  +R  +   + R   GAP P PP
Sbjct: 918 PEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 962



 Score = 93.6 bits (231), Expect = 4e-19
 Identities = 152/643 (23%), Positives = 196/643 (30%), Gaps = 167/643 (25%)

Query: 2   PVPP-PPAPPPPPTFALANT--------EKPTLNKTEQAGRNALLSDISKGKKLKKTVTN 52
           P PP  P PPPP T A             KP   +    G   +     +    +   T+
Sbjct: 27  PRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTS 86

Query: 53  DRSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGL----------GG 102
            R+        G G           G     G   G    G  G  GL          G 
Sbjct: 87  SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146

Query: 103 LFQAGMPKLRSTANRDNDSG---GSRPPLLPPGGRST-----------SAKPFSPPSGPG 148
             +A      S   R + SG   G+  P +    R+            SA+P  P  GP 
Sbjct: 147 ATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPR 206

Query: 149 RFPVPSPGHRSGPPEPQRNRMPPPRPDVGS---KPDSIPPPVPSTP--RPIQSSPHNRGS 203
           +    +  H +  P P   R    RP  G    +P S      +TP   P +S P  RG+
Sbjct: 207 KSVSSASEHSTTEPSPAARR----RPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGT 262

Query: 204 PPVPGGPRQPSPGPT-----PPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSR 258
           P  P  P QP P        P   P  +  A   G +  SPL++ SP   +    P P  
Sbjct: 263 PRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDN 322

Query: 259 ALDDKPP--PPPPPVGNR-----------PSIHREAVPPPPPQNNKPPVPSTPRPSA--- 302
           A    P   PP PP+              PS+     PP  P +  PP  +TP   A   
Sbjct: 323 AATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPS 382

Query: 303 ----------------SSQAPPPP-----------------------------------P 311
                           S QAPP P                                    
Sbjct: 383 LQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLT 442

Query: 312 PPSRPGP-PPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLP------------ 358
            PSRP   PP  P        P  P    SLS +  PL SP    PL             
Sbjct: 443 SPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQA 502

Query: 359 -----------------PPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALP--ATP 399
                            PP  + PP  +  PP  + P   PPP+ +  S     P   TP
Sbjct: 503 PLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPL-QTASAPLTTPHLETP 561

Query: 400 QLPSRSGVDSPRSGPRPPLPPDRPSAGA-PPPPPPSTSIRNGFQDSPCEDEWESRFYFHP 458
             P+   + +P S    P PP+ PS+ A PPP  P        Q  P            P
Sbjct: 562 PCPAPCPLQAPPSPLTTP-PPETPSSIATPPPQAPPALASPPLQGLPSP----------P 610

Query: 459 ISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPI 501
           +S L  P P      + P   A     +        +PPL P+
Sbjct: 611 LSPLATPPPQAPPXLALPPLQAPPSPPA--------SPPLSPL 645



 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 119/404 (29%), Positives = 143/404 (35%), Gaps = 105/404 (25%)

Query: 121 SGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVP-SPGHRSGPPEPQRNRMPPPRPDVGSK 179
           SG    P+ PP   +T      PPS P   P+P +P   S PP  Q    PP  P   + 
Sbjct: 310 SGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAP 369

Query: 180 PDSIPPPVPSTPR-----PIQSSPHNRGSPPVPG-------------------------- 208
           P    PP+ + P      PIQ  PH+  SP +                            
Sbjct: 370 PSMTTPPMQAPPSLQTIPPIQV-PHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHS 428

Query: 209 ----GPRQ-------PS-PGPTPPPFPGNRG-----------TALGGG-SIRQSPL---- 240
                PRQ       PS P  TPP  P  +            T+L    S   SPL    
Sbjct: 429 FLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHP 488

Query: 241 ----------SSSSPFSN--RPPLPPTPSRALDDKPPPPP----PPVGNRPSIHREAVPP 284
                     S  +P S+   PPL    S A      PP     PP+ N PS+      P
Sbjct: 489 LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSL-----AP 543

Query: 285 PPPQNNKPPV-------PSTPRPSASSQAPPPP---PPPSRPG----PPPLPPSSSGNDE 330
           PP Q    P+       P  P P    QAPP P   PPP  P     PPP  P +  +  
Sbjct: 544 PPLQTASAPLTTPHLETPPCPAP-CPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP 602

Query: 331 TPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGS 390
              LP   LS  ++ PP   P  +  LPP  +  PP P   PP    PL  P P + N  
Sbjct: 603 LQGLPSPPLSPLATPPPQAPPXLA--LPPLQA--PPSPPASPP--LSPLATPSPQAPNAL 656

Query: 391 TSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPPPS 434
               L A    P    V +P S P    PP  PSA  P   PPS
Sbjct: 657 AVHLLQAPFSPPPSPPVQAPFSPPAS--PPVSPSATPPSQAPPS 698



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 87/348 (25%), Positives = 113/348 (32%), Gaps = 87/348 (25%)

Query: 226 RGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPP-----------VGNR 274
           R  A  G + R     +    + RPP  P        +PPPP  P           VG +
Sbjct: 5   RDKAKAGAAARTPAARAPGLLTPRPPGSP--------RPPPPVTPAALRVLGAAGAVGRK 56

Query: 275 PSIHR----------EAVPPPPPQNNKPPVPSTP--RPSASSQAP-PPPPPPSRPGPPPL 321
           P   R          E+ P   P  +       P  RP AS +    PP   + PGP   
Sbjct: 57  PLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS 116

Query: 322 PPSSSGNDETPRLPQRNLSLSSS----------------------------TPPLPSP-- 351
           P  +SG      L Q+ L +S+                             TP  PSP  
Sbjct: 117 PGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAM 176

Query: 352 -------GRSGPLP-PPPSERPPPPVRDP------PGRSGPLPPPPPVSRNGSTSRAL-- 395
                  G    LP P PS RP PP   P              P P   R  S    L  
Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQR 236

Query: 396 PATPQL-PSRSGVDSP-RSGPRPPLPPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESR 453
           PA+  L  S + + SP RSGP     P  P+  + P P    ++R      P +D   + 
Sbjct: 237 PASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA- 295

Query: 454 FYFHPISDLPPPEPYVQTTKSYPSKLARNESRSGSNRRERGAPPLPPI 501
               P+S  P   P    TK+ P     N     +       PP PP+
Sbjct: 296 --LGPLSSSPLATPSPSGTKARPVPPPDN----AATPLPATLPPSPPL 337



 Score = 29.6 bits (65), Expect = 6.7
 Identities = 26/90 (28%), Positives = 34/90 (37%), Gaps = 8/90 (8%)

Query: 2    PVPPPPAP------PPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRS 55
            P    PAP      P P T             + ++ + A L ++  G      V +  S
Sbjct: 981  PESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLS 1040

Query: 56   APILDKPKGAGAGGGGGGFGG--GGGFGGG 83
              +L       AGG GGG GG  GGG  GG
Sbjct: 1041 RTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 1070



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 14/25 (56%), Positives = 14/25 (56%)

Query: 65   AGAGGGGGGFGGGGGFGGGGGGGGG 89
            A A G  GG GGG G   GGG  GG
Sbjct: 1046 AAAEGAAGGSGGGPGGAEGGGVTGG 1070



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 13/26 (50%), Positives = 13/26 (50%)

Query: 75   GGGGGFGGGGGGGGGGSFGGGGPPGL 100
            G  GG GGG GG  GG   GG    L
Sbjct: 1050 GAAGGSGGGPGGAEGGGVTGGARAAL 1075


>gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]
          Length = 638

 Score =  108 bits (271), Expect = 9e-24
 Identities = 103/324 (31%), Positives = 123/324 (37%), Gaps = 68/324 (20%)

Query: 148 GRFPVP-SPGHRSGP--------PEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSP 198
           G  PVP S G  SGP        P P      PP P + S   S PP + S P   +S P
Sbjct: 321 GEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPS--ESRP 378

Query: 199 HNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPT--P 256
           ++      PGGP    P   P P P   G   GG  ++ +P     P+   PP P    P
Sbjct: 379 YHGMHGGGPGGP-GGGPHSFPHPLPSLTG-GHGGHPMQHNPNGPPPPWMQPPPPPMNQGP 436

Query: 257 SRALDDKPPP------------------------PPPPVGNRPSIHREAVPPPPPQNNKP 292
                  PPP                        PPPP+G  P       PPPPP    P
Sbjct: 437 HPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPP------PPPPPSGQPP 490

Query: 293 PVPSTPRP--SASSQAPPPPPPP--SRPGPPPLP--------PSSSGNDETPRLPQRNLS 340
           P PS P P      Q PPPPPPP  S     PLP         +S+G    P   Q+  +
Sbjct: 491 PPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAA 550

Query: 341 LSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPAT-P 399
            ++S       G    +P PP  +PP     PPG   P PPPPP    GS    +P    
Sbjct: 551 AAASPGAPQMQGNPTMVPLPPGVQPPL----PPGAPPPPPPPPP----GSAGMMIPPRGG 602

Query: 400 QLPSRSGVDSPRSGPRPPLPPDRP 423
             PS    D PR  P   LP  +P
Sbjct: 603 DGPSHESEDFPR--PLVTLPGRQP 624



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 97/348 (27%), Positives = 115/348 (33%), Gaps = 98/348 (28%)

Query: 171 PPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSP-----GPTPP-PFPG 224
           P    VGS       P+ S PRP  ++P N   PP      Q  P     GP+   P+ G
Sbjct: 324 PVPASVGSTSGPATTPLASAPRP--AAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHG 381

Query: 225 NRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPS----RALDDKPPPPPPPVGNRPSIHRE 280
             G   GG            P S   PLP          +   P  PPPP          
Sbjct: 382 MHGGGPGG--------PGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQ------- 426

Query: 281 AVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPP---SSSGNDETPRLPQR 337
             PPPPP N  P                   PP   GPPP+     S+       RL Q 
Sbjct: 427 --PPPPPMNQGPH------------------PPGHHGPPPMDQYLGSTPVGSGVYRLHQ- 465

Query: 338 NLSLSSSTPPLPSPGRSGPLPPPPS--ERPPPPVRDPP---GRSGPLPPPPPVSRNGST- 391
                    P P  G   P PPPPS    PPP    PP    +  P PPPPP S   S+ 
Sbjct: 466 ----GKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASST 521

Query: 392 -----------------------------SRALPATPQLPSRSGVDSPRSGPRPPLPPDR 422
                                        + A P  PQ+     +     G +PPLPP  
Sbjct: 522 PLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPP-- 579

Query: 423 PSAGAPPPPPPSTSIRNGFQDSPCEDE---WESRFYFHPISDLPPPEP 467
              GAPPPPPP      G    P   +    ES  +  P+  LP  +P
Sbjct: 580 ---GAPPPPPPPPPGSAGMMIPPRGGDGPSHESEDFPRPLVTLPGRQP 624



 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 102/398 (25%), Positives = 123/398 (30%), Gaps = 145/398 (36%)

Query: 2   PVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDK 61
           P  P   PPPP   +   +  P +N                            S P   +
Sbjct: 346 PAAPANNPPPPSLMSTTQSRPPWMN----------------------------SGPSESR 377

Query: 62  PKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDS 121
           P           + G  G G GG GGG  SF    P   GG    G P       + N +
Sbjct: 378 P-----------YHGMHGGGPGGPGGGPHSFPHPLPSLTGG--HGGHPM------QHNPN 418

Query: 122 GGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQ---------------- 165
           G   P + PP           PP   G  P   PGH   PP  Q                
Sbjct: 419 GPPPPWMQPP----------PPPMNQGPHP---PGHHGPPPMDQYLGSTPVGSGVYRLHQ 465

Query: 166 -RNRMPPP----RPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPP 220
            +  MPPP     P     P   PPP PS P P       +  PP P  P       TP 
Sbjct: 466 GKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPP--PSSSMASSTPL 523

Query: 221 PFPGN---RGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSI 277
           P+  N     T+ G GSI                 PP   +       P  P +   P++
Sbjct: 524 PWQQNTTTTTTSAGTGSI-----------------PPWQQQQAAAAASPGAPQMQGNPTM 566

Query: 278 HREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQR 337
               VP PP    +PP+P          APPPPPPP        PP S+G          
Sbjct: 567 ----VPLPP--GVQPPLP--------PGAPPPPPPP--------PPGSAG---------- 594

Query: 338 NLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGR 375
                     +  P R G  P   SE  P P+   PGR
Sbjct: 595 ----------MMIPPRGGDGPSHESEDFPRPLVTLPGR 622



 Score = 29.3 bits (64), Expect = 8.7
 Identities = 38/130 (29%), Positives = 44/130 (33%), Gaps = 22/130 (16%)

Query: 97  PPGLGGLFQAGMPKLRSTANRDNDSG-GSRPP--------LLPPGGRSTSAKPFSPPSGP 147
           PP         +P  ++T      +G GS PP           PG       P   P  P
Sbjct: 512 PPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPP 571

Query: 148 GRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVP 207
           G  P   PG    PP       PPP P  GS    IPP     P   +S    R    +P
Sbjct: 572 GVQPPLPPG---APPP------PPP-PPPGSAGMMIPPRGGDGPSH-ESEDFPRPLVTLP 620

Query: 208 GGPRQPSPGP 217
           G  RQP   P
Sbjct: 621 G--RQPQQRP 628


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score =  104 bits (260), Expect = 2e-22
 Identities = 78/228 (34%), Positives = 93/228 (40%), Gaps = 54/228 (23%)

Query: 210 PRQPSPGPTPP--PFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPP 267
           P  PS  P PP  P PG+ GT +                      PP P+      PPPP
Sbjct: 565 PSVPSRAPVPPAPPLPGDSGTII----------------------PPPPAPGDSTTPPPP 602

Query: 268 PPPVGNRPSIHREAVPPPPPQNNKPPVPSTPR-PSASSQAPPPPPPPSRPGPPPLP-PSS 325
           PPP            PPPPP      + S P  P  ++ +PPPP       PPP P P  
Sbjct: 603 PPP-----------PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG 651

Query: 326 SGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV 385
            G      LP      ++  PP P PG S  +PP     PPPP+   PG +G  PPPPP+
Sbjct: 652 VGIPSPSSLP----GGTAIPPPPPLPG-SARIPP-----PPPPL---PGSAGIPPPPPPL 698

Query: 386 SRNGSTSRALPATPQLPSRSGVDSPRSGP-RPPLPPDRPSAGAPPPPP 432
                     P  P LP   G+  P   P  P +PP  P  G PPPPP
Sbjct: 699 PGEAGMP---PPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPP 743



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 73/201 (36%), Positives = 83/201 (41%), Gaps = 42/201 (20%)

Query: 253 PPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP 312
           P  PSRA    P PP PP+   P      +PPPP   +    P  P        PPPPPP
Sbjct: 565 PSVPSRA----PVPPAPPL---PGDSGTIIPPPPAPGDSTTPPPPP--------PPPPPP 609

Query: 313 PSRPG------PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS----------PGRSGP 356
           P  PG      PP LP    G   +P  P    +     PPLP           PG +  
Sbjct: 610 PPLPGGVCISSPPSLP---GGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAI 666

Query: 357 LPPPP---SERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSG 413
            PPPP   S R PPP    PG +G  PPPPP+          P  P LP   G+  P   
Sbjct: 667 PPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMP---PPPPPLPGGPGIPPPPPF 723

Query: 414 PRPP-LPPDRPSAGAPPPPPP 433
           P  P +PP  P  G  PPPPP
Sbjct: 724 PGGPGIPPPPPGMGM-PPPPP 743



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 76/208 (36%), Positives = 84/208 (40%), Gaps = 31/208 (14%)

Query: 143 PPSGPGRFPVPSPGHRSGPPEPQRNRM---PPPRPDVGSKPDSIPPPVPSTPRPIQSSPH 199
           PPS P R PVP       PP P  +     PPP P   + P   PPP P  P P+     
Sbjct: 564 PPSVPSRAPVPP-----APPLPGDSGTIIPPPPAPGDSTTPPP-PPPPPPPPPPLPGGVC 617

Query: 200 NRGSPPVPGG----PRQPSPG----PTPPPFPGNRG----TALGGGSIRQSPLSSSSPFS 247
               P +PGG    P  P  G    P PPP P   G    ++L GG+    P     P S
Sbjct: 618 ISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPP--PPLPGS 675

Query: 248 NRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAP 307
            R P PP P       PPPPPP  G         +PPPPP    P  P  P P      P
Sbjct: 676 ARIPPPPPPLPGSAGIPPPPPPLPGEA------GMPPPPPP--LPGGPGIPPPPPFPGGP 727

Query: 308 PPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             PPPP   G PP PP   G    P LP
Sbjct: 728 GIPPPPPGMGMPPPPPFGFGVPAAPVLP 755



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 83/231 (35%), Positives = 97/231 (41%), Gaps = 46/231 (19%)

Query: 182 SIPPPVPS-TPRPIQSSPHNRGSPPVPGG-----PRQPSPGP--T--PPPFPGNRGTALG 231
           ++PP VPS  P P         +PP+PG      P  P+PG   T  PPP P      L 
Sbjct: 562 TVPPSVPSRAPVP--------PAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLP 613

Query: 232 GGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVG-NRPSIHR----EAVPPPP 286
           GG    SP S     +  PP P +    +   PPPPP P G   PS        A+PPPP
Sbjct: 614 GGVCISSPPSLPGGTAISPPPPLSGDATI---PPPPPLPEGVGIPSPSSLPGGTAIPPPP 670

Query: 287 --PQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSS 344
             P + + P P  P P ++   PPPPP P   G PP PP   G    P            
Sbjct: 671 PLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIP------------ 718

Query: 345 TPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRAL 395
            PP P PG  G  PPPP    PPP   PP   G   P  PV   G T + L
Sbjct: 719 -PPPPFPGGPGIPPPPPGMGMPPP---PPFGFG--VPAAPVLPFGLTPKKL 763



 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 71/209 (33%), Positives = 81/209 (38%), Gaps = 41/209 (19%)

Query: 120 DSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPE-PQRNRMPPPRPDVGS 178
           DSG   PP   PG  +T   P  PP  P   P+P     S PP  P    + PP P  G 
Sbjct: 582 DSGTIIPPPPAPGDSTTPPPPPPPPPPPP--PLPGGVCISSPPSLPGGTAISPPPPLSGD 639

Query: 179 KPDSIPPPVPS-----TPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGG 233
                PPP+P      +P  +         PP+PG  R P   P PPP PG+ G      
Sbjct: 640 ATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP---PPPPPLPGSAGIP---- 692

Query: 234 SIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPP 293
                           PP PP P  A     PPPPPP+   P I     PPPPP    P 
Sbjct: 693 ----------------PPPPPLPGEA---GMPPPPPPLPGGPGI-----PPPPPFPGGPG 728

Query: 294 VPSTPRPSASSQAPPPPPPPSRPGPPPLP 322
           +P  P P      PPPP     P  P LP
Sbjct: 729 IP--PPPPGMGMPPPPPFGFGVPAAPVLP 755



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 58/158 (36%), Positives = 71/158 (44%), Gaps = 40/158 (25%)

Query: 302 ASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP 361
           AS  A     PPS P   P+PP+       P LP  + ++    PP P+PG S   PPPP
Sbjct: 554 ASLSAAAITVPPSVPSRAPVPPA-------PPLPGDSGTI---IPPPPAPGDSTTPPPPP 603

Query: 362 SERPPPP-------VRDPPGRSG--PLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRS 412
              PPPP       +  PP   G   + PPPP+S + +    +P  P LP   G+ SP S
Sbjct: 604 PPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDAT----IPPPPPLPEGVGIPSPSS 659

Query: 413 GPR----------------PPLPPDRP-SAGAPPPPPP 433
            P                 PP PP  P SAG PPPPPP
Sbjct: 660 LPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPP 697



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 46/138 (33%), Positives = 56/138 (40%), Gaps = 34/138 (24%)

Query: 330 ETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP------SERPPPPV----RDPPGRSGPL 379
           E  +    +LS ++ T P   P R+   P PP      +  PPPP       PP    P 
Sbjct: 547 EDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP 606

Query: 380 PPPPPV----------SRNGSTS----------RALPATPQLPSRSGVDSPRSGPR---- 415
           PPPPP+          S  G T+            +P  P LP   G+ SP S P     
Sbjct: 607 PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAI 666

Query: 416 PPLPPDRPSAGAPPPPPP 433
           PP PP   SA  PPPPPP
Sbjct: 667 PPPPPLPGSARIPPPPPP 684



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 61/212 (28%), Positives = 73/212 (34%), Gaps = 49/212 (23%)

Query: 2   PVPPPPAPPPPPTF--ALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPIL 59
           P PPPP PPPPP     +  +  P+L      G  A    IS    L    T     P+ 
Sbjct: 599 PPPPPPPPPPPPPLPGGVCISSPPSL-----PGGTA----ISPPPPLSGDATIPPPPPL- 648

Query: 60  DKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDN 119
             P+G G        GG                    PP L G  +   P          
Sbjct: 649 --PEGVGIPSPSSLPGG---------------TAIPPPPPLPGSARIPPPPPPLPG---- 687

Query: 120 DSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            S G  PP  PP     +  P  PP  PG   +P P     PP P    +PPP P +G  
Sbjct: 688 -SAGIPPP--PPPLPGEAGMPPPPPPLPGGPGIPPP-----PPFPGGPGIPPPPPGMGMP 739

Query: 180 PDSIPPP----VPSTP-RPIQSSPHNRGSPPV 206
           P   PPP    VP+ P  P   +P     P V
Sbjct: 740 P---PPPFGFGVPAAPVLPFGLTPKKLYKPEV 768


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score =  104 bits (260), Expect = 2e-22
 Identities = 78/228 (34%), Positives = 93/228 (40%), Gaps = 54/228 (23%)

Query: 210 PRQPSPGPTPP--PFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPP 267
           P  PS  P PP  P PG+ GT +                      PP P+      PPPP
Sbjct: 574 PSVPSRAPVPPAPPLPGDSGTII----------------------PPPPAPGDSTTPPPP 611

Query: 268 PPPVGNRPSIHREAVPPPPPQNNKPPVPSTPR-PSASSQAPPPPPPPSRPGPPPLP-PSS 325
           PPP            PPPPP      + S P  P  ++ +PPPP       PPP P P  
Sbjct: 612 PPP-----------PPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEG 660

Query: 326 SGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPV 385
            G      LP      ++  PP P PG S  +PP     PPPP+   PG +G  PPPPP+
Sbjct: 661 VGIPSPSSLP----GGTAIPPPPPLPG-SARIPP-----PPPPL---PGSAGIPPPPPPL 707

Query: 386 SRNGSTSRALPATPQLPSRSGVDSPRSGP-RPPLPPDRPSAGAPPPPP 432
                     P  P LP   G+  P   P  P +PP  P  G PPPPP
Sbjct: 708 PGEAGMP---PPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPP 752



 Score = 98.2 bits (243), Expect = 2e-20
 Identities = 73/201 (36%), Positives = 83/201 (41%), Gaps = 42/201 (20%)

Query: 253 PPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPP 312
           P  PSRA    P PP PP+   P      +PPPP   +    P  P        PPPPPP
Sbjct: 574 PSVPSRA----PVPPAPPL---PGDSGTIIPPPPAPGDSTTPPPPP--------PPPPPP 618

Query: 313 PSRPG------PPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPS----------PGRSGP 356
           P  PG      PP LP    G   +P  P    +     PPLP           PG +  
Sbjct: 619 PPLPGGVCISSPPSLP---GGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAI 675

Query: 357 LPPPP---SERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSG 413
            PPPP   S R PPP    PG +G  PPPPP+          P  P LP   G+  P   
Sbjct: 676 PPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMP---PPPPPLPGGPGIPPPPPF 732

Query: 414 PRPP-LPPDRPSAGAPPPPPP 433
           P  P +PP  P  G  PPPPP
Sbjct: 733 PGGPGIPPPPPGMGM-PPPPP 752



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 76/208 (36%), Positives = 84/208 (40%), Gaps = 31/208 (14%)

Query: 143 PPSGPGRFPVPSPGHRSGPPEPQRNRM---PPPRPDVGSKPDSIPPPVPSTPRPIQSSPH 199
           PPS P R PVP       PP P  +     PPP P   + P   PPP P  P P+     
Sbjct: 573 PPSVPSRAPVPP-----APPLPGDSGTIIPPPPAPGDSTTPPP-PPPPPPPPPPLPGGVC 626

Query: 200 NRGSPPVPGG----PRQPSPG----PTPPPFPGNRG----TALGGGSIRQSPLSSSSPFS 247
               P +PGG    P  P  G    P PPP P   G    ++L GG+    P     P S
Sbjct: 627 ISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPP--PPLPGS 684

Query: 248 NRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAP 307
            R P PP P       PPPPPP  G         +PPPPP    P  P  P P      P
Sbjct: 685 ARIPPPPPPLPGSAGIPPPPPPLPGEA------GMPPPPPP--LPGGPGIPPPPPFPGGP 736

Query: 308 PPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             PPPP   G PP PP   G    P LP
Sbjct: 737 GIPPPPPGMGMPPPPPFGFGVPAAPVLP 764



 Score = 95.5 bits (236), Expect = 1e-19
 Identities = 83/231 (35%), Positives = 97/231 (41%), Gaps = 46/231 (19%)

Query: 182 SIPPPVPS-TPRPIQSSPHNRGSPPVPGG-----PRQPSPGP--T--PPPFPGNRGTALG 231
           ++PP VPS  P P         +PP+PG      P  P+PG   T  PPP P      L 
Sbjct: 571 TVPPSVPSRAPVP--------PAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLP 622

Query: 232 GGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVG-NRPSIHR----EAVPPPP 286
           GG    SP S     +  PP P +    +   PPPPP P G   PS        A+PPPP
Sbjct: 623 GGVCISSPPSLPGGTAISPPPPLSGDATI---PPPPPLPEGVGIPSPSSLPGGTAIPPPP 679

Query: 287 --PQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSS 344
             P + + P P  P P ++   PPPPP P   G PP PP   G    P            
Sbjct: 680 PLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIP------------ 727

Query: 345 TPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRAL 395
            PP P PG  G  PPPP    PPP   PP   G   P  PV   G T + L
Sbjct: 728 -PPPPFPGGPGIPPPPPGMGMPPP---PPFGFG--VPAAPVLPFGLTPKKL 772



 Score = 92.4 bits (228), Expect = 8e-19
 Identities = 71/209 (33%), Positives = 81/209 (38%), Gaps = 41/209 (19%)

Query: 120 DSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPE-PQRNRMPPPRPDVGS 178
           DSG   PP   PG  +T   P  PP  P   P+P     S PP  P    + PP P  G 
Sbjct: 591 DSGTIIPPPPAPGDSTTPPPPPPPPPPPP--PLPGGVCISSPPSLPGGTAISPPPPLSGD 648

Query: 179 KPDSIPPPVPS-----TPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGG 233
                PPP+P      +P  +         PP+PG  R P   P PPP PG+ G      
Sbjct: 649 ATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIP---PPPPPLPGSAGIP---- 701

Query: 234 SIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPP 293
                           PP PP P  A     PPPPPP+   P I     PPPPP    P 
Sbjct: 702 ----------------PPPPPLPGEA---GMPPPPPPLPGGPGI-----PPPPPFPGGPG 737

Query: 294 VPSTPRPSASSQAPPPPPPPSRPGPPPLP 322
           +P  P P      PPPP     P  P LP
Sbjct: 738 IP--PPPPGMGMPPPPPFGFGVPAAPVLP 764



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 58/158 (36%), Positives = 71/158 (44%), Gaps = 40/158 (25%)

Query: 302 ASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP 361
           AS  A     PPS P   P+PP+       P LP  + ++    PP P+PG S   PPPP
Sbjct: 563 ASLSAAAITVPPSVPSRAPVPPA-------PPLPGDSGTI---IPPPPAPGDSTTPPPPP 612

Query: 362 SERPPPP-------VRDPPGRSG--PLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRS 412
              PPPP       +  PP   G   + PPPP+S + +    +P  P LP   G+ SP S
Sbjct: 613 PPPPPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDAT----IPPPPPLPEGVGIPSPSS 668

Query: 413 GPR----------------PPLPPDRP-SAGAPPPPPP 433
            P                 PP PP  P SAG PPPPPP
Sbjct: 669 LPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPP 706



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 46/138 (33%), Positives = 56/138 (40%), Gaps = 34/138 (24%)

Query: 330 ETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPP------SERPPPPV----RDPPGRSGPL 379
           E  +    +LS ++ T P   P R+   P PP      +  PPPP       PP    P 
Sbjct: 556 EDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP 615

Query: 380 PPPPPV----------SRNGSTS----------RALPATPQLPSRSGVDSPRSGPR---- 415
           PPPPP+          S  G T+            +P  P LP   G+ SP S P     
Sbjct: 616 PPPPPLPGGVCISSPPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAI 675

Query: 416 PPLPPDRPSAGAPPPPPP 433
           PP PP   SA  PPPPPP
Sbjct: 676 PPPPPLPGSARIPPPPPP 693



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 61/212 (28%), Positives = 73/212 (34%), Gaps = 49/212 (23%)

Query: 2   PVPPPPAPPPPPTF--ALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPIL 59
           P PPPP PPPPP     +  +  P+L      G  A    IS    L    T     P+ 
Sbjct: 608 PPPPPPPPPPPPPLPGGVCISSPPSL-----PGGTA----ISPPPPLSGDATIPPPPPL- 657

Query: 60  DKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDN 119
             P+G G        GG                    PP L G  +   P          
Sbjct: 658 --PEGVGIPSPSSLPGG---------------TAIPPPPPLPGSARIPPPPPPLPG---- 696

Query: 120 DSGGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK 179
            S G  PP  PP     +  P  PP  PG   +P P     PP P    +PPP P +G  
Sbjct: 697 -SAGIPPP--PPPLPGEAGMPPPPPPLPGGPGIPPP-----PPFPGGPGIPPPPPGMGMP 748

Query: 180 PDSIPPP----VPSTP-RPIQSSPHNRGSPPV 206
           P   PPP    VP+ P  P   +P     P V
Sbjct: 749 P---PPPFGFGVPAAPVLPFGLTPKKLYKPEV 777


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score =  104 bits (260), Expect = 2e-22
 Identities = 87/262 (33%), Positives = 99/262 (37%), Gaps = 59/262 (22%)

Query: 122 GGSRPPLLPPGGRSTSAKPFSPPSGPGRFPVPS-PGHRSGPPEPQRNRMPPPRPDVGSKP 180
           GGS     P GGR     P + P G  RFP P+ PG   GPP P      PPRP +G   
Sbjct: 190 GGSSRAAFPQGGRGRGRFPGAVPGGD-RFPGPAGPG---GPPPPFPAGQTPPRPPLGPPG 245

Query: 181 DSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPL 240
              PP  P  P P Q  P     PP+ G P +    P P  FPG                
Sbjct: 246 ---PPGPPGPPPPGQVLP-----PPLAGPPNRGDRPPPPVLFPGQP-------------- 283

Query: 241 SSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRP 300
               P    PP PP P       P PPPP  G           PPPP    PP P  P  
Sbjct: 284 FGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQG-----------PPPPPGPFPPRPPGPLG 332

Query: 301 SASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPP----LPSPGRSGP 356
              + APPP  P   PG PP              P  +++ +   PP    +P+    GP
Sbjct: 333 PPLTLAPPPHLPGPPPGAPP--------------PAPHVNPAFFPPPTNSGMPTSDSRGP 378

Query: 357 LPPPPSERPPPPVR---DPPGR 375
            P  P  RPPP  R    PPGR
Sbjct: 379 PPTDPYGRPPPYDRGDYGPPGR 400



 Score = 99.0 bits (245), Expect = 9e-21
 Identities = 93/303 (30%), Positives = 110/303 (36%), Gaps = 66/303 (21%)

Query: 25  LNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGAGGGGGGFGGGGGFGGGG 84
           L K E  G+N +++  +K + L +     R      +  G G  G  GG      F  GG
Sbjct: 144 LPKRELHGQNPVVTPCNK-QFLSQFEMQSRKTTQSGQMSGEGKAGPPGG-SSRAAFPQGG 201

Query: 85  GGGG---GGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF 141
            G G   G   GG   PG  G                   GG  PP   P G++    P 
Sbjct: 202 RGRGRFPGAVPGGDRFPGPAG------------------PGGPPPPF--PAGQTPPRPPL 241

Query: 142 SPPSGPGRFPVPSPGHRSGPP---EPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSP 198
            PP  PG    P PG    PP    P R   PPP      +P   PP  P  P P     
Sbjct: 242 GPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGP----- 296

Query: 199 HNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSR 258
                PPVPG    P PGP PP               +Q P     PF  RPP P  P  
Sbjct: 297 ----PPPVPG--YGPPPGPPPP---------------QQGPPPPPGPFPPRPPGPLGPPL 335

Query: 259 ALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNK---PPVPSTPRPSASSQAPPPPPPPSR 315
            L   P  P PP G          PPP P  N    PP  ++  P++ S+ PPP  P  R
Sbjct: 336 TLAPPPHLPGPPPG---------APPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGR 386

Query: 316 PGP 318
           P P
Sbjct: 387 PPP 389



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 84/259 (32%), Positives = 98/259 (37%), Gaps = 70/259 (27%)

Query: 185 PPVPSTPRPIQSSPHNRGSPP--VPGGPRQPSP---GPTPPPFPGNRGTALGGGSIRQSP 239
           PP  S+          RG  P  VPGG R P P   G  PPPFP        G +  + P
Sbjct: 188 PPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPA-------GQTPPRPP 240

Query: 240 LSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPP------PQNNKP- 292
           L    P    PP PP P + L       PPP+   P+  R   PPPP      P    P 
Sbjct: 241 LGPPGPPG--PPGPPPPGQVL-------PPPLAGPPN--RGDRPPPPVLFPGQPFGQPPL 289

Query: 293 -PVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSP 351
            P+P  P P      PPP PPP + GPPP                              P
Sbjct: 290 GPLPPGPPPPVPGYGPPPGPPPPQQGPPP-----------------------------PP 320

Query: 352 GRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPR 411
           G   P PP P   PP  +  PP   GP P  PP + + +     PA    P+ SG+  P 
Sbjct: 321 GPFPPRPPGPL-GPPLTLAPPPHLPGPPPGAPPPAPHVN-----PAFFPPPTNSGM--PT 372

Query: 412 SGPRPPLPPDRPSAGAPPP 430
           S  R P P D    G PPP
Sbjct: 373 SDSRGPPPTD--PYGRPPP 389



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 72/213 (33%), Positives = 80/213 (37%), Gaps = 55/213 (25%)

Query: 279 REAVPPPPPQNNKPPVPS----TPRPSASSQAPPPPP--PPSRPGPPPLPPSSSGNDETP 332
           R   P   P  ++ P P+     P P  + Q PP PP  PP  PGPP  PP         
Sbjct: 204 RGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPPGPPGPPPPGQV----- 258

Query: 333 RLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLP--PPPPVSRNGS 390
            LP          PPL  P   G  PPPP   P  P   PP   GPLP  PPPPV   G 
Sbjct: 259 -LP----------PPLAGPPNRGDRPPPPVLFPGQPFGQPP--LGPLPPGPPPPVPGYGP 305

Query: 391 TSRALPATPQLPSRSGVDSPRSGPRPPLPP---DRPSAGAPPP---------PPPSTSIR 438
                P  P  P +     P  GP PP PP     P   APPP         PPP+  + 
Sbjct: 306 -----PPGPPPPQQG--PPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVN 358

Query: 439 NGFQDSPCEDEWESRFYFHPISDL---PPPEPY 468
             F   P            P SD    PP +PY
Sbjct: 359 PAFFPPPTNSGM-------PTSDSRGPPPTDPY 384


>gi|239754955 PREDICTED: similar to COL22A1 protein [Homo sapiens]
          Length = 1073

 Score =  103 bits (256), Expect = 5e-22
 Identities = 124/422 (29%), Positives = 148/422 (35%), Gaps = 69/422 (16%)

Query: 66  GAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSR 125
           GA G  G  G  G  G  G  G  G+ G  GPPG       G P LR T  +D + G   
Sbjct: 383 GAKGQEGAHGAPGAAGNPGAPGHVGAPGPSGPPG-----SVGAPGLRGTPGKDGERGEK- 436

Query: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPP 185
                  G   S  P  P   PG   +P P  +    EP     P     +G+K D   P
Sbjct: 437 ----GAAGEEGSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRGSPGLPGPLGTKGDRGAP 492

Query: 186 PVPSTPRPIQSSPHNRGSPPVPGGP--RQPSPGPTP-PPFPGNRGTA-LGGGSIRQSP-- 239
            +P +P            PP P GP   + SPG    P FPG +G A   G S   SP  
Sbjct: 493 GIPGSPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRGLPGFPGPQGPAGRDGLSSLLSPGD 552

Query: 240 --LSSSSPFSNRPPLPP-TPSRA--LDDKPPPPPPPVGNRPSIHREAVPP--PPPQNNKP 292
             L +    ++ PP PP  P       DK  P  P          EA PP  P P     
Sbjct: 553 INLLAKDVCNDCPPGPPGLPGLPGFKGDKGVPGKPGREGTEGKKGEAGPPGLPGPPGIAG 612

Query: 293 PVPSTPRPSA-------SSQAPPPPP----PPSRPGPPPL-------------------- 321
           P  S     A         Q  P  P    PP  PGPP                      
Sbjct: 613 PQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGNPGPPGADGIAGAAGPPGIQGSPGKEG 672

Query: 322 PPSSSGNDETPRLPQRNLSLSSSTPPLP--SPGRSGP--LPPPPSERPPPPVRDPPGRSG 377
           PP   G    P +P           P P   PG++G   LP P   R PP  +   G SG
Sbjct: 673 PPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPGLPGPEGARGPPGFKGHTGDSG 732

Query: 378 PLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPPDRP-----SAGAPPPPP 432
                 P  R  S +  LP    LP + G D+  +GP+ P  P  P     S G+P  P 
Sbjct: 733 -----APGPRGESGAMGLPGQEGLPGKDG-DTGPTGPQGPQGPRGPPGKNGSPGSPGEPG 786

Query: 433 PS 434
           PS
Sbjct: 787 PS 788



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 125/478 (26%), Positives = 154/478 (32%), Gaps = 100/478 (20%)

Query: 54  RSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGG-GGSFGGGGPPGLGGLFQAGMPKLR 112
           ++AP L +  G     G  G  G  G  G  G  G  G  G  G  GL G    G P +R
Sbjct: 240 KTAPGLKQLNGEPGERGEDGLPGKPGLRGEIGEQGLAGRPGEKGEAGLPGA--PGFPGVR 297

Query: 113 STANRDNDSGG-SRPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHR----SGPPEPQRN 167
                  + G    P L    G    A P  PP  PG   + +P  R     GP   + +
Sbjct: 298 GEKGDQGEKGELGLPGLKGDRGEKGEAGPAGPPGLPGTTSLFTPHPRMPGEQGPKGEKGD 357

Query: 168 RMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQP----SPGPTPPP-- 221
              P  P +  +P  + P  P+ P   +      G+P   G P  P    +PGP+ PP  
Sbjct: 358 PGLPGEPGLQGRPGELGPQGPTGPPGAKGQEGAHGAPGAAGNPGAPGHVGAPGPSGPPGS 417

Query: 222 --FPGNRGTALGGGSIRQSPLS----SSSPFSNR-----PPLPPTPSRALDDKP-----P 265
              PG RGT    G   +   +    S  P   R     P LP  P +  D +P     P
Sbjct: 418 VGAPGLRGTPGKDGERGEKGAAGEEGSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRGSP 477

Query: 266 PPPPPVGNRPSIHREAVPPPPPQNNK-------PPVPSTPRPSASSQA-------PPPPP 311
             P P+G +       +P  P            PP PS P     S         P P  
Sbjct: 478 GLPGPLGTKGDRGAPGIPGSPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRGLPGFPGPQG 537

Query: 312 PPSR------------------------PGPPPLP--PSSSGNDETPRLPQR----NLSL 341
           P  R                        PGPP LP  P   G+   P  P R        
Sbjct: 538 PAGRDGLSSLLSPGDINLLAKDVCNDCPPGPPGLPGLPGFKGDKGVPGKPGREGTEGKKG 597

Query: 342 SSSTPPLPS-PGRSGPL--------------------PPPPSERPPPPVRDPPGRSGPLP 380
            +  P LP  PG +GP                     P  P    PP    PPG  G   
Sbjct: 598 EAGPPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGNPGPPGADGIAG 657

Query: 381 PPPPVSRNGSTSRALPATPQ----LPSRSGVDSPRSGPRPPLPPDRP-SAGAPPPPPP 433
              P    GS  +  P  PQ    LP   G +        P PP  P  AG P  P P
Sbjct: 658 AAGPPGIQGSPGKEGPPGPQGPSGLPGIPGEEGKEGRDGKPGPPGEPGKAGEPGLPGP 715



 Score = 82.4 bits (202), Expect = 9e-16
 Identities = 142/551 (25%), Positives = 181/551 (32%), Gaps = 114/551 (20%)

Query: 6    PPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGA 65
            PP PP  P       +K    K  + G        ++GKK +         P +  P+G+
Sbjct: 565  PPGPPGLPGLPGFKGDKGVPGKPGREG--------TEGKKGEAGPPGLPGPPGIAGPQGS 616

Query: 66   -GAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPGLGGLF-QAGMPKLRSTANRDNDSGG 123
             G  G  G  G  G  G  G  G  G  G  GPPG  G+   AG P ++ +  ++   G 
Sbjct: 617  QGERGADGEVGQKGDQGHPGVPGFMGPPGNPGPPGADGIAGAAGPPGIQGSPGKEGPPGP 676

Query: 124  SRPPLLP-----PGGRSTSAKPFSPPSGPGRFPVP----------------------SPG 156
              P  LP      G      KP  PP  PG+   P                      +PG
Sbjct: 677  QGPSGLPGIPGEEGKEGRDGKP-GPPGEPGKAGEPGLPGPEGARGPPGFKGHTGDSGAPG 735

Query: 157  HR--------------------SGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQS 196
             R                    +GP  PQ  + P   P     P S   P PS     + 
Sbjct: 736  PRGESGAMGLPGQEGLPGKDGDTGPTGPQGPQGPRGPPGKNGSPGSPGEPGPSGTPGQKG 795

Query: 197  SPHNRGSPPVPG--GPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSP-FSNRPPLP 253
            S    GSP +PG  GPR P   P     PG  G           P     P F      P
Sbjct: 796  SKGENGSPGLPGFLGPRGPPGEPGEKGVPGKEGV----------PGKPGEPGFKGERGDP 845

Query: 254  PTPSRALDDKPPPPPPPVGNRPSI--HREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPP 311
                    DK PP        P I  H+       PQ     +P    P        PP 
Sbjct: 846  GIKG----DKGPPGGKGQPGDPGIPGHKGHTGLMGPQG----LPGENGPVG------PPG 891

Query: 312  PPSRPGPPPLPPSSSGNDETPRLPQRNLS---------LSSSTPPL---PSPGRSGPLPP 359
            PP +PG P L   S   +   RL Q  L          L +  PP     S GR GP   
Sbjct: 892  PPGQPGFPGLRGESPSMETLRRLIQEELGKQLETRLAYLLAQMPPAYMKSSQGRPGP--- 948

Query: 360  PPSERPPPPVRDP-PGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPL 418
                 P PP +D  PGR+GP+  P    + G    + P  P+     G       P   L
Sbjct: 949  -----PGPPGKDGLPGRAGPMGEPGRPGQGGLEGPSGPIGPK--GERGAKGDPGAPGVGL 1001

Query: 419  PPDRPSAGAPPPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLP-PPEPYVQTTKSYPS 477
              +    G P  P      ++G    P   + E+    HP   LP PP P  Q   S  +
Sbjct: 1002 RGEMGPPGIPGQPGEPGYAKDGLPGIP-GPQGETGPAGHP--GLPGPPGPPGQCDPSQCA 1058

Query: 478  KLARNESRSGS 488
              A   +R G+
Sbjct: 1059 YFASLAARPGN 1069



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 112/402 (27%), Positives = 139/402 (34%), Gaps = 62/402 (15%)

Query: 54  RSAPILDKPKGAGAGGGGGGFGGGGGFGGGGGGGGGGSFGGGGPPG----LGGLFQAGMP 109
           R +P L  P G     G  G  G  G  G  G G  G  G  GPPG     G     G P
Sbjct: 474 RGSPGLPGPLGTKGDRGAPGIPGSPGSRGDPGIGVAGPPGPSGPPGDKGSPGSRGLPGFP 533

Query: 110 KLRSTANRDNDSGGSRPPLLPPGGRSTSAKPF---SPPSGPGRFPVPS-PGHRSGPPEPQ 165
             +  A RD  S      LL PG  +  AK      PP  PG   +P   G +  P +P 
Sbjct: 534 GPQGPAGRDGLSS-----LLSPGDINLLAKDVCNDCPPGPPGLPGLPGFKGDKGVPGKPG 588

Query: 166 RNRMPPPRPDVGSKPDSIP-PPVPSTPRPIQ---------SSPHNRGSPPVPGGPRQP-S 214
           R      + + G  P  +P PP  + P+  Q             ++G P VPG    P +
Sbjct: 589 REGTEGKKGEAG--PPGLPGPPGIAGPQGSQGERGADGEVGQKGDQGHPGVPGFMGPPGN 646

Query: 215 PGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNR 274
           PGP     PG  G A   G     P    SP    PP P  PS          P   G  
Sbjct: 647 PGP-----PGADGIAGAAG----PPGIQGSPGKEGPPGPQGPSGL--------PGIPGEE 689

Query: 275 PSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRL 334
               R+  P PP +  K   P  P P   ++ PP     +     P P   SG    P  
Sbjct: 690 GKEGRDGKPGPPGEPGKAGEPGLPGPE-GARGPPGFKGHTGDSGAPGPRGESGAMGLP-- 746

Query: 335 PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSG----PLPPPPPVSRNGS 390
            Q  L           PG+ G   P   + P  P R PPG++G    P  P P  +    
Sbjct: 747 GQEGL-----------PGKDGDTGPTGPQGPQGP-RGPPGKNGSPGSPGEPGPSGTPGQK 794

Query: 391 TSRALPATPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPPPP 432
            S+    +P LP   G   P   P     P +      P  P
Sbjct: 795 GSKGENGSPGLPGFLGPRGPPGEPGEKGVPGKEGVPGKPGEP 836


>gi|19718731 bromodomain-containing protein 4 isoform long [Homo
            sapiens]
          Length = 1362

 Score =  103 bits (256), Expect = 5e-22
 Identities = 78/275 (28%), Positives = 108/275 (39%), Gaps = 40/275 (14%)

Query: 126  PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPP 185
            PP  PP  +     P  PPS P +    +P  +S PP     ++P   P +   P S+  
Sbjct: 765  PPPPPPQQQQQPPPPPPPPSMPQQ---AAPAMKSSPPPFIATQVPVLEPQL---PGSVFD 818

Query: 186  PVPSTPRPIQSSPHNRGSPPVPGGPRQPSPG-----------------PTPPPFPGNRGT 228
            P+    +PI   P     P +P  P   +P                  P  P  P NR  
Sbjct: 819  PIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAA 878

Query: 229  ALGGGSIRQ---SPLSSSSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREA---V 282
            AL     R    SP  + +P   +PP+   P   L+D+ PP PP    +  ++ +    V
Sbjct: 879  ALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKV 938

Query: 283  PPPPP--------QNNKPPVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPR- 333
             PP P            PP+P  P PS   Q    PPPP  P P P PP    +   PR 
Sbjct: 939  QPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPPPP--PPPQPQPPPQQQHQPPPRP 996

Query: 334  LPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPP 368
            +  + +  S+     P P    P  PPP ++PPPP
Sbjct: 997  VHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPP 1031



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 76/257 (29%), Positives = 98/257 (38%), Gaps = 51/257 (19%)

Query: 266 PPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPP----PPPPPSRPGPPPL 321
           PPPPP        ++  PPPPPQ  + P P  P PS   QA P     PPP      P L
Sbjct: 757 PPPPP--------QQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVL 808

Query: 322 PPSSSGNDETPRLPQRNLSLSSSTPP---LPSPGRSGPLPPPPSERPPP-----PVRDPP 373
            P   G+   P        +   T P   LP P     LP PP    PP      V  PP
Sbjct: 809 EPQLPGSVFDP--------IGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPP 860

Query: 374 GRSGPLPPPPPVSRNGSTSRALPATPQLP---SRSGVDSPRSGPRPPL--PPDRPSAGAP 428
                LP  P  SR  + + ALP  P  P   S +   +P   P+PP+  PP        
Sbjct: 861 ALHNALPQQP--SRPSNRAAALPPKPARPPAVSPALTQTPLL-PQPPMAQPPQVLLEDEE 917

Query: 429 PPPPPSTSIRNGFQDSPCEDEWESRFYFHPISDLPPPEPYVQTTK--SYPSKLARNESRS 486
           PP PP TS+             + + Y   +  + PP P + + K  S P          
Sbjct: 918 PPAPPLTSM-------------QMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHP 964

Query: 487 GSNRRERGAPPLPPIPR 503
              ++ +  PP PP P+
Sbjct: 965 SVQQQLQQQPPPPPPPQ 981



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 61/226 (26%), Positives = 80/226 (35%), Gaps = 29/226 (12%)

Query: 126  PPLLPPGGRSTSAKPFSPPSGPGRF-PVPSPGHRSGPPEPQRNRMPPPRPDVGSKPDSIP 184
            PP  PP  +    +   PP  P    P+    H   PP PQ  +  PP P  G +P   P
Sbjct: 975  PPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQ--PPHPPPGQQP---P 1029

Query: 185  PPVPSTPRPI---QSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLS 241
            PP P+ P+ +     SP +  S P   G  + +P P     P          S  QS   
Sbjct: 1030 PPQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQM--------SQFQSLTH 1081

Query: 242  SSSPFSNRPPLPPTPSRALDDKPPP---------PPPPVGNRP-SIHREAVPPPPPQNNK 291
             S P  N  P       A   +P P           P + + P S      PP  P++ K
Sbjct: 1082 QSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIK 1141

Query: 292  PPV--PSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLP 335
             PV  P  P         P   PP +  PPP  P      + P+ P
Sbjct: 1142 APVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTP 1187



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 47/167 (28%), Positives = 63/167 (37%), Gaps = 26/167 (15%)

Query: 291 KPPVPSTPRPSASS-----QAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSST 345
           KP V + P  + +S     Q P P PPP +  P P P        TP L  +   ++   
Sbjct: 190 KPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAV------TPDLIVQTPVMTVVP 243

Query: 346 P-PLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPP----VSRNGSTSRAL----- 395
           P PL +P    P P PP    P PV+  P      P P      V R   T+        
Sbjct: 244 PQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPI 303

Query: 396 ---PATPQLPSRSGVDSPRSGPRPPLPP--DRPSAGAPPPPPPSTSI 437
              P+ P  P  + +   R   RP  PP  D P +   P P  S+ +
Sbjct: 304 HEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKV 350



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 46/169 (27%), Positives = 67/169 (39%), Gaps = 36/169 (21%)

Query: 269 PPVGNRPSIHREAVPPPP--PQNNKPPVPSTPRPSAS------------SQAPP-----P 309
           P V   P+  + + PP    PQ N PPV +TP P  +            +  PP     P
Sbjct: 191 PGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTP 250

Query: 310 PPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPP-- 367
           PP P +P PPP P         P+  Q +  + ++TP  P   + G      +  P    
Sbjct: 251 PPVPPQPQPPPAP--------APQPVQSHPPIIAATPQ-PVKTKKGVKRKADTTTPTTID 301

Query: 368 PVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP 416
           P+ +PP     LPP P  ++ G   R   + P  P +  V   +  P P
Sbjct: 302 PIHEPPS----LPPEPKTTKLG--QRRESSRPVKPPKKDVPDSQQHPAP 344



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 49/182 (26%), Positives = 68/182 (37%), Gaps = 36/182 (19%)

Query: 190 TPRPIQSSPHNRGSPPVPGGPRQPSPGP-----TPPPFPGNRGTALGGGSIRQSPLSS-- 242
           T +P  S+  N      P   + P P P     TP PFP     A+    I Q+P+ +  
Sbjct: 188 TAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFP-----AVTPDLIVQTPVMTVV 242

Query: 243 -SSPFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPS 301
              P    PP+PP        +P PPP P             P P Q++ P + +TP+P 
Sbjct: 243 PPQPLQTPPPVPP--------QPQPPPAPA------------PQPVQSHPPIIAATPQPV 282

Query: 302 ASSQA---PPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLP 358
            + +          P+   P   PPS     +T +L QR  S     PP      S   P
Sbjct: 283 KTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHP 342

Query: 359 PP 360
            P
Sbjct: 343 AP 344



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 47/181 (25%), Positives = 60/181 (33%), Gaps = 44/181 (24%)

Query: 147 PGRFPVPSPGHRSGPPEPQRNRMPPP------------RPD----------VGSKPDSIP 184
           PG   VP+    S PP+ Q  +  PP             PD          V  +P   P
Sbjct: 191 PGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQPLQTP 250

Query: 185 PPVPSTPRPIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSS 244
           PPVP  P+P    P      PV   P  P    TP P    +G      +   + +    
Sbjct: 251 PPVPPQPQP----PPAPAPQPVQSHP--PIIAATPQPVKTKKGVKRKADTTTPTTI---D 301

Query: 245 PFSNRPPLPPTPSRALDDKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASS 304
           P    P LPP P              +G R    R   P  PP+ + P     P P  SS
Sbjct: 302 PIHEPPSLPPEPKTT----------KLGQRRESSR---PVKPPKKDVPDSQQHPAPEKSS 348

Query: 305 Q 305
           +
Sbjct: 349 K 349



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 56/210 (26%), Positives = 76/210 (36%), Gaps = 31/210 (14%)

Query: 125  RPPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRM-----PPPRP----- 174
            RP  L P   ST  +   PP G  + P P PG +  PP+P + +        PR      
Sbjct: 995  RPVHLQPMQFSTHIQQPPPPQGQ-QPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDP 1053

Query: 175  -DVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPG-GPR----QPSPGPTPPPFPGNRGT 228
               G   ++  P +  +P+  Q       SPP     P+    + +    P P    +  
Sbjct: 1054 YSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEE 1113

Query: 229  ALGGGSIRQSPLSSSSPFSNRPPLPPTPSRA---LDDKPPPPPPPVGNRPSIHREAVPPP 285
             +    IR  P S S      PP  P   +A   L  +P   P  VG RP I        
Sbjct: 1114 KIHSPIIRSEPFSPS--LRPEPPKHPESIKAPVHLPQRPEMKPVDVG-RPVIR------- 1163

Query: 286  PPQNNKPPVPSTPRPSASSQAPPPPPPPSR 315
            PP+ N PP P  P      Q P  P  P +
Sbjct: 1164 PPEQNAPP-PGAPDKDKQKQEPKTPVAPKK 1192



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 37/158 (23%), Positives = 53/158 (33%), Gaps = 30/158 (18%)

Query: 296 STPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSG 355
           S    S+ S +       +   P        G ++       +  +  +  P+P      
Sbjct: 701 SESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPP 760

Query: 356 PLPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPAT-------------PQLP 402
           P  PPP   PPPP +    +  P PPPPP S     + A+ ++             PQLP
Sbjct: 761 PQQPPP---PPPPQQ----QQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLP 813

Query: 403 SRSGVDSPRSG--------PRPPLPPDRPSAGAPPPPP 432
               V  P           P+P LPP  P       PP
Sbjct: 814 --GSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPP 849



 Score = 34.3 bits (77), Expect = 0.27
 Identities = 26/75 (34%), Positives = 28/75 (37%), Gaps = 8/75 (10%)

Query: 372 PPGRSGPLPPPPPVSRNGSTSRALPA-TPQLPSRSGVDSPRSGPRPPLPPDRPSAGAPPP 430
           PP    P P PPPV    +T    PA TP L     V +P     PP P   P    P P
Sbjct: 205 PPQTQTPQPNPPPVQ---ATPHPFPAVTPDLI----VQTPVMTVVPPQPLQTPPPVPPQP 257

Query: 431 PPPSTSIRNGFQDSP 445
            PP        Q  P
Sbjct: 258 QPPPAPAPQPVQSHP 272



 Score = 30.4 bits (67), Expect = 3.9
 Identities = 18/61 (29%), Positives = 24/61 (39%), Gaps = 6/61 (9%)

Query: 2   PVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDK 61
           PVPP P PPP P      +  P +  T Q  +        KG K K   T   +   + +
Sbjct: 252 PVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKT------KKGVKRKADTTTPTTIDPIHE 305

Query: 62  P 62
           P
Sbjct: 306 P 306


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.137    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,224,320
Number of Sequences: 37866
Number of extensions: 4541116
Number of successful extensions: 164694
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2281
Number of HSP's successfully gapped in prelim test: 2764
Number of HSP's that attempted gapping in prelim test: 20951
Number of HSP's gapped (non-prelim): 49465
length of query: 503
length of database: 18,247,518
effective HSP length: 107
effective length of query: 396
effective length of database: 14,195,856
effective search space: 5621558976
effective search space used: 5621558976
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press